A systematic FPGA acceleration design for applications based on convolutional neural networks
NASA Astrophysics Data System (ADS)
Dong, Hao; Jiang, Li; Li, Tianjian; Liang, Xiaoyao
2018-04-01
Most FPGA accelerators for convolutional neural network are designed to optimize the inner acceleration and are ignored of the optimization for the data path between the inner accelerator and the outer system. This could lead to poor performance in applications like real time video object detection. We propose a brand new systematic FPFA acceleration design to solve this problem. This design takes the data path optimization between the inner accelerator and the outer system into consideration and optimizes the data path using techniques like hardware format transformation, frame compression. It also takes fixed-point, new pipeline technique to optimize the inner accelerator. All these make the final system's performance very good, reaching about 10 times the performance comparing with the original system.
Microelectromechanical safing and arming apparatus
DOE Office of Scientific and Technical Information (OSTI.GOV)
Koehler, David R; Hoke, Darren A; Weichman, Louis S
2006-05-30
A two-stage acceleration sensing apparatus is disclosed which has applications for use in a fuze assembly for a projected munition. The apparatus, which can be formed by bulk micromachining or LIGA, can sense acceleration components along two orthogonal directions to enable movement of a shuttle from an "as-fabricated" position to a final position and locking of the shuttle in the final position. With the shuttle moved to the final position, the apparatus can perform one or more functions including completing an explosive train or an electrical switch closure, or allowing a light beam to be transmitted through the device.
Microelectromechanical safing and arming apparatus
DOE Office of Scientific and Technical Information (OSTI.GOV)
Koehler, David R; Hoke, Darren A; Weichman, Louis S
2008-06-10
A two-stage acceleration sensing apparatus is disclosed which has applications for use in a fuze assembly for a projected munition. The apparatus, which can be formed by bulk micromachining or LIGA, can sense acceleration components along two orthogonal directions to enable movement of a shuttle from an "as-fabricated" position to a final position and locking of the shuttle in the final position. With the shuttle moved to the final position, the apparatus can perform one or more functions including completing an explosive train or an electrical switch closure, or allowing a light beam to be transmitted through the device.
A Novel Method for Vertical Acceleration Noise Suppression of a Thrust-Vectored VTOL UAV.
Li, Huanyu; Wu, Linfeng; Li, Yingjie; Li, Chunwen; Li, Hangyu
2016-12-02
Acceleration is of great importance in motion control for unmanned aerial vehicles (UAVs), especially during the takeoff and landing stages. However, the measured acceleration is inevitably polluted by severe noise. Therefore, a proper noise suppression procedure is required. This paper presents a novel method to reduce the noise in the measured vertical acceleration for a thrust-vectored tail-sitter vertical takeoff and landing (VTOL) UAV. In the new procedure, a Kalman filter is first applied to estimate the UAV mass by using the information in the vertical thrust and measured acceleration. The UAV mass is then used to compute an estimate of UAV vertical acceleration. The estimated acceleration is finally fused with the measured acceleration to obtain the minimum variance estimate of vertical acceleration. By doing this, the new approach incorporates the thrust information into the acceleration estimate. The method is applied to the data measured in a VTOL UAV takeoff experiment. Two other denoising approaches developed by former researchers are also tested for comparison. The results demonstrate that the new method is able to suppress the acceleration noise substantially. It also maintains the real-time performance in the final estimated acceleration, which is not seen in the former denoising approaches. The acceleration treated with the new method can be readily used in the motion control applications for UAVs to achieve improved accuracy.
A Novel Method for Vertical Acceleration Noise Suppression of a Thrust-Vectored VTOL UAV
Li, Huanyu; Wu, Linfeng; Li, Yingjie; Li, Chunwen; Li, Hangyu
2016-01-01
Acceleration is of great importance in motion control for unmanned aerial vehicles (UAVs), especially during the takeoff and landing stages. However, the measured acceleration is inevitably polluted by severe noise. Therefore, a proper noise suppression procedure is required. This paper presents a novel method to reduce the noise in the measured vertical acceleration for a thrust-vectored tail-sitter vertical takeoff and landing (VTOL) UAV. In the new procedure, a Kalman filter is first applied to estimate the UAV mass by using the information in the vertical thrust and measured acceleration. The UAV mass is then used to compute an estimate of UAV vertical acceleration. The estimated acceleration is finally fused with the measured acceleration to obtain the minimum variance estimate of vertical acceleration. By doing this, the new approach incorporates the thrust information into the acceleration estimate. The method is applied to the data measured in a VTOL UAV takeoff experiment. Two other denoising approaches developed by former researchers are also tested for comparison. The results demonstrate that the new method is able to suppress the acceleration noise substantially. It also maintains the real-time performance in the final estimated acceleration, which is not seen in the former denoising approaches. The acceleration treated with the new method can be readily used in the motion control applications for UAVs to achieve improved accuracy. PMID:27918422
Optics measurement and correction during beam acceleration in the Relativistic Heavy Ion Collider
DOE Office of Scientific and Technical Information (OSTI.GOV)
Liu, C.; Marusic, A.; Minty, M.
2014-09-09
To minimize operational complexities, setup of collisions in high energy circular colliders typically involves acceleration with near constant β-functions followed by application of strong focusing quadrupoles at the interaction points (IPs) for the final beta-squeeze. At the Relativistic Heavy Ion Collider (RHIC) beam acceleration and optics squeeze are performed simultaneously. In the past, beam optics correction at RHIC has taken place at injection and at final energy with some interpolation of corrections into the acceleration cycle. Recent measurements of the beam optics during acceleration and squeeze have evidenced significant beta-beats which if corrected could minimize undesirable emittance dilutions and maximizemore » the spin polarization of polarized proton beams by avoidance of higher-order multipole fields sampled by particles within the bunch. In this report the methodology now operational at RHIC for beam optics corrections during acceleration with simultaneous beta-squeeze will be presented together with measurements which conclusively demonstrate the superior beam control. As a valuable by-product, the corrections have minimized the beta-beat at the profile monitors so reducing the dominant error in and providing more precise measurements of the evolution of the beam emittances during acceleration.« less
NASA Astrophysics Data System (ADS)
Wang, W. P.; Shen, B. F.; Xu, Z. Z.
2017-01-01
The accelerating gradient of a proton beam is a crucial factor for the stable radiation pressure acceleration, because quickly accelerating protons into the relativistic region may reduce the multidimensional instability grow to a certain extent. In this letter, a shape-tailored laser is designed to accelerate the protons in a controllable high accelerating gradient in theory. Finally, a proton beam in the gigaelectronvolt range with an energy spread of ˜2.4% is obtained in one-dimensional particle-in-cell simulations. With the future development of the high-intense laser, the ability to accelerate a high energy proton beam using a shape-tailored laser will be important for realistic proton applications, such as fast ignition for inertial confinement fusion, medical therapy, and proton imaging.
Developments of AMS at the TANDAR accelerator
NASA Astrophysics Data System (ADS)
Fernández Niello, J. O.; Abriola, D.; Alvarez, D. E.; Capurro, O. A.; di Tada, M.; Etchegoyen, A.; Ferrero, A. M. J.; Martí, G. V.; Pacheco, A. J.; Testoni, J. E.; Korschinek, G.
1996-08-01
Man-made long-lived radioisotopes have been produced as a result of different nuclear technologies. The study of accidental spillages and the determination of radioisotope concentrations in nuclear waste prior to final storage in a repository are subjects of great interest in connection with this activity. The accelerator mass spectrometry (AMS) technique is a powerful tool to measure long-lived isotopes at abundance ratios as low as 10 -12-10 -15 in small samples. Applications to the Argentine nuclear program like those mentioned above, as well as applications to archaeology, hydrology and biomedical research, are considered in an AMS program using the TANDAR 20 UD electrostatic accelerator at Buenos Aires. In this work we present the status of the program and a description of the facility.
NASA Astrophysics Data System (ADS)
Labate, Luca; Andreassi, Maria Grazia; Baffigi, Federica; Basta, Giuseppina; Bizzarri, Ranieri; Borghini, Andrea; Candiano, Giuliana C.; Casarino, Carlo; Cresci, Monica; Di Martino, Fabio; Fulgentini, Lorenzo; Ghetti, Francesco; Gilardi, Maria Carla; Giulietti, Antonio; Köster, Petra; Lenci, Francesco; Levato, Tadzio; Oishi, Yuji; Russo, Giorgio; Sgarbossa, Antonella; Traino, Claudio; Gizzi, Leonida A.
2013-05-01
Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.
Analysis and measurement of the transfer matrix of a 9-cell, 1.3-GHz superconducting cavity
Halavanau, A.; Eddy, N.; Edstrom, D.; ...
2017-04-13
Superconducting linacs are capable of producing intense, stable, high-quality electron beams that have found widespread applications in science and industry. Here, the 9-cell, 1.3-GHz superconducting standing-wave accelerating rf cavity originally developed for e +/e - linear-collider applications has been broadly employed in various superconducting-linac designs. In this paper we discuss the transfer matrix of such a cavity and present its measurement performed at the Fermilab Accelerator Science and Technology (FAST) facility. Finally, the experimental results are found to be in agreement with analytical calculations and numerical simulations.
Illinois Accelerator Research Center
Kroc, Thomas K.; Cooper, Charlie A.
2017-10-26
The Illinois Accelerator Research Center (IARC) hosts a new accelerator development program at Fermi National Accelerator Laboratory. IARC provides access to Fermi's state-of-the-art facilities and technologies for research, development and industrialization of particle accelerator technology. In addition to facilitating access to available existing Fermi infrastructure, the IARC Campus has a dedicated 36,000 ft2 heavy assembly building (HAB) with all the infrastructure needed to develop, commission and operate new accelerators. Connected to the HAB is a 47,000 ft Office, Technology and Engineering (OTE) building, paid for by the state, that has office, meeting, and light technical space. The OTE building, whichmore » contains the Accelerator Physics Center, and nearby Accelerator and Technical divisions provide IARC collaborators with unique access to world class expertise in a wide array of accelerator technologies. Finally, at IARC scientists and engineers from Fermilab and academia work side by side with industrial partners to develop breakthroughs in accelerator science and translate them into applications for the nation's health, wealth and security.« less
Illinois Accelerator Research Center
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kroc, Thomas K.; Cooper, Charlie A.
The Illinois Accelerator Research Center (IARC) hosts a new accelerator development program at Fermi National Accelerator Laboratory. IARC provides access to Fermi's state-of-the-art facilities and technologies for research, development and industrialization of particle accelerator technology. In addition to facilitating access to available existing Fermi infrastructure, the IARC Campus has a dedicated 36,000 ft2 heavy assembly building (HAB) with all the infrastructure needed to develop, commission and operate new accelerators. Connected to the HAB is a 47,000 ft Office, Technology and Engineering (OTE) building, paid for by the state, that has office, meeting, and light technical space. The OTE building, whichmore » contains the Accelerator Physics Center, and nearby Accelerator and Technical divisions provide IARC collaborators with unique access to world class expertise in a wide array of accelerator technologies. Finally, at IARC scientists and engineers from Fermilab and academia work side by side with industrial partners to develop breakthroughs in accelerator science and translate them into applications for the nation's health, wealth and security.« less
ELIMED: a new hadron therapy concept based on laser driven ion beams
NASA Astrophysics Data System (ADS)
Cirrone, Giuseppe A. P.; Margarone, Daniele; Maggiore, Mario; Anzalone, Antonello; Borghesi, Marco; Jia, S. Bijan; Bulanov, Stepan S.; Bulanov, Sergei; Carpinelli, Massimo; Cavallaro, Salvatore; Cutroneo, Mariapompea; Cuttone, Giacomo; Favetta, Marco; Gammino, Santo; Klimo, Ondrej; Manti, Lorenzo; Korn, Georg; La Malfa, Giuseppe; Limpouch, Jiri; Musumarra, Agatino; Petrovic, Ivan; Prokupek, Jan; Psikal, Jan; Ristic-Fira, Aleksandra; Renis, Marcella; Romano, Francesco P.; Romano, Francesco; Schettino, Giuseppe; Schillaci, Francesco; Scuderi, Valentina; Stancampiano, Concetta; Tramontana, Antonella; Ter-Avetisyan, Sargis; Tomasello, Barbara; Torrisi, Lorenzo; Tudisco, Salvo; Velyhan, Andriy
2013-05-01
Laser accelerated proton beams have been proposed to be used in different research fields. A great interest has risen for the potential replacement of conventional accelerating machines with laser-based accelerators, and in particular for the development of new concepts of more compact and cheaper hadrontherapy centers. In this context the ELIMED (ELI MEDical applications) research project has been launched by INFN-LNS and ASCR-FZU researchers within the pan-European ELI-Beamlines facility framework. The ELIMED project aims to demonstrate the potential clinical applicability of optically accelerated proton beams and to realize a laser-accelerated ion transport beamline for multi-disciplinary user applications. In this framework the eye melanoma, as for instance the uveal melanoma normally treated with 62 MeV proton beams produced by standard accelerators, will be considered as a model system to demonstrate the potential clinical use of laser-driven protons in hadrontherapy, especially because of the limited constraints in terms of proton energy and irradiation geometry for this particular tumour treatment. Several challenges, starting from laser-target interaction and beam transport development up to dosimetry and radiobiology, need to be overcome in order to reach the ELIMED final goals. A crucial role will be played by the final design and realization of a transport beamline capable to provide ion beams with proper characteristics in terms of energy spectrum and angular distribution which will allow performing dosimetric tests and biological cell irradiation. A first prototype of the transport beamline has been already designed and other transport elements are under construction in order to perform a first experimental test with the TARANIS laser system by the end of 2013. A wide international collaboration among specialists of different disciplines like Physics, Biology, Chemistry, Medicine and medical doctors coming from Europe, Japan, and the US is growing up around the ELIMED project with the aim to work on the conceptual design, technical and experimental realization of this core beamline of the ELI Beamlines facility.
Analysis Of The IJCNN 2011 UTL Challenge
2012-01-13
large datasets from various application domains: handwriting recognition, image recognition, video processing, text processing, and ecology. The goal...validation and final evaluation sets consist of 4096 examples each. Dataset Domain Features Sparsity Devel. Transf. AVICENNA Handwriting 120 0% 150205...documents [3]. Transfer learning methods could accelerate the application of handwriting recognizers to historical manuscript by reducing the need for
Fundamental Principles of Coherent-Feedback Quantum Control
2014-12-08
in metrology (acceleration sensing, vibrometry, gravity wave detection) and in quantum information processing (continuous-variables quantum ...AFRL-OSR-VA-TR-2015-0009 FUNDAMENTAL PRINCIPLES OF COHERENT-FEEDBACK QUANTUM CONTROL Hideo Mabuchi LELAND STANFORD JUNIOR UNIV CA Final Report 12/08...foundations and potential applications of coherent-feedback quantum control. We have focused on potential applications in quantum -enhanced metrology and
NASA Technical Reports Server (NTRS)
Reichelt, Mark
1993-01-01
In this paper we describe a novel generalized SOR (successive overrelaxation) algorithm for accelerating the convergence of the dynamic iteration method known as waveform relaxation. A new convolution SOR algorithm is presented, along with a theorem for determining the optimal convolution SOR parameter. Both analytic and experimental results are given to demonstrate that the convergence of the convolution SOR algorithm is substantially faster than that of the more obvious frequency-independent waveform SOR algorithm. Finally, to demonstrate the general applicability of this new method, it is used to solve the differential-algebraic system generated by spatial discretization of the time-dependent semiconductor device equations.
Development of an Electron-Positron Source for Positron Annihilation Lifetime Spectroscopy
2009-12-19
REPORT Development of an electron- positron source for positron annihilation lifetime spectroscopy : FINAL REPORT 14. ABSTRACT 16. SECURITY...to generate radiation, to accelerate particles, and to produce electrons and positrons from vacuum. From applications using existing high-repetition...theoretical directions. This report reviews work directed toward the application of positron generation from laser interaction with matter 1. REPORT DATE
DOT National Transportation Integrated Search
2001-05-01
The purpose of this working paper is to provide an estimate of the federal proportion of funds expended on intelligent transportation systems (ITS) infrastructure deployments for fiscal year (FY) 2000 using budget and planning data from state departm...
Superconducting RF, the History, Challenges and Promise
Padamsee, Hasan
2018-01-01
After a short survey of on-going accelerator applications, I will discuss future applications prospects for this enabling technology, both near term and long term. A selection of technology highlights will serve as an introduction to outstanding issues for all types of applications, from pulsed high gradient to CW medium gradient. Finally I will touch upon the limits of niobium and the prospects of new materials. The talk will be targeted at a general audience.
Parametric investigations of target normal sheath acceleration experiments
NASA Astrophysics Data System (ADS)
Zani, Alessandro; Sgattoni, Andrea; Passoni, Matteo
2011-10-01
One of the most important challenges related to laser-driven ion acceleration research is to actively control some important ion beam features. This is a peculiar topic in the light of future possible technological applications. In the present work we make use of one theoretical model for target normal sheath acceleration in order to reproduce recent experimental parametric studies about maximum ion energy dependencies on laser parameters. The key role played by pulse energy and intensity is enlightened. Finally the effective dependence of maximum ion energy on intensity is evaluated using a combined theoretical approach, obtained by means of an analytical and a particle-in-cell numerical investigation.
Accelerators for Discovery Science and Security applications
NASA Astrophysics Data System (ADS)
Todd, A. M. M.; Bluem, H. P.; Jarvis, J. D.; Park, J. H.; Rathke, J. W.; Schultheiss, T. J.
2015-05-01
Several Advanced Energy Systems (AES) accelerator projects that span applications in Discovery Science and Security are described. The design and performance of the IR and THz free electron laser (FEL) at the Fritz-Haber-Institut der Max-Planck-Gesellschaft in Berlin that is now an operating user facility for physical chemistry research in molecular and cluster spectroscopy as well as surface science, is highlighted. The device was designed to meet challenging specifications, including a final energy adjustable in the range of 15-50 MeV, low longitudinal emittance (<50 keV-psec) and transverse emittance (<20 π mm-mrad), at more than 200 pC bunch charge with a micropulse repetition rate of 1 GHz and a macropulse length of up to 15 μs. Secondly, we will describe an ongoing effort to develop an ultrafast electron diffraction (UED) source that is scheduled for completion in 2015 with prototype testing taking place at the Brookhaven National Laboratory (BNL) Accelerator Test Facility (ATF). This tabletop X-band system will find application in time-resolved chemical imaging and as a resource for drug-cell interaction analysis. A third active area at AES is accelerators for security applications where we will cover some top-level aspects of THz and X-ray systems that are under development and in testing for stand-off and portal detection.
The Munich accelerator for fission fragments MAFF
NASA Astrophysics Data System (ADS)
Habs, D.; Groß, M.; Assmann, W.; Ames, F.; Bongers, H.; Emhofer, S.; Heinz, S.; Henry, S.; Kester, O.; Neumayr, J.; Ospald, F.; Reiter, P.; Sieber, T.; Szerypo, J.; Thirolf, P. G.; Varentsov, V.; Wilfart, T.; Faestermann, T.; Krücken, R.; Maier-Komor, P.
2003-05-01
The Munich Accelerator for Fission Fragments MAFF has been designed for the new Munich research reactor FRM-II. It will deliver several intense beams (˜3×10 11 s -1) of very neutron-rich fission fragments with a final energy of 30 keV (low-energy beam) or energies between 3.7 and 5.9 MeV· A (high-energy beam). Such beams are of interest for the creation of super-heavy elements by fusion reactions, nuclear spectroscopy of exotic nuclei, but they also have a potential for applications, e.g. in medicine. Presently the Munich research reactor FRM-II is ready for operation, but authorities delay the final permission to turn the reactor critical probably till the end of 2002. Only after this final permission the financing of the major parts of MAFF can start. On the other hand all major components have been designed and special components have been tested in separate setups.
DOT National Transportation Integrated Search
1994-06-01
The extent and duration of pollution from herbicide spills and deliberate applications is related to properties of the herbicide and soil. Objectives of this study included the development of experimental procedures and mathematical models to determi...
Gauging the cosmic acceleration with recent type Ia supernovae data sets
NASA Astrophysics Data System (ADS)
Velten, Hermano; Gomes, Syrios; Busti, Vinicius C.
2018-04-01
We revisit a model-independent estimator for cosmic acceleration based on type Ia supernovae distance measurements. This approach does not rely on any specific theory for gravity, energy content, nor parametrization for the scale factor or deceleration parameter and is based on falsifying the null hypothesis that the Universe never expanded in an accelerated way. By generating mock catalogs of known cosmologies, we test the robustness of this estimator, establishing its limits of applicability. We detail the pros and cons of such an approach. For example, we find that there are specific counterexamples in which the estimator wrongly provides evidence against acceleration in accelerating cosmologies. The dependence of the estimator on the H0 value is also discussed. Finally, we update the evidence for acceleration using the recent UNION2.1 and Joint Light-Curve Analysis samples. Contrary to recent claims, available data strongly favor an accelerated expansion of the Universe in complete agreement with the standard Λ CDM model.
NASA Astrophysics Data System (ADS)
John, Kevin
2017-01-01
Targeted radiotherapy is an emerging discipline of cancer therapy that exploits the biochemical differences between normal cells and cancer cells to selectively deliver a lethal dose of radiation to cancer cells, while leaving healthy cells relatively unperturbed. A broad overview of targeted alpha therapy including isotope production methods, and associated isotope production facility needs, will be provided. A more general overview of the US Department of Energy Isotope Program's Tri-Lab (ORNL, BNL, LANL) Research Effort to Provide Accelerator-Produced 225Ac for Radiotherapy will also be presented focusing on the accelerator-production of 225Ac and final product isolation methodologies for medical applications.
Accelerated Climate Modeling for Energy (ACME) Final Scientific/Technical Report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chaudhary, Aashish
Seven Department of Energy (DOE) national laboratories, Universities, and Kitware, undertook a coordinated effort to build an Earth system modeling capability tailored to meet the climate change research strategic objectives of the DOE Office of Science, as well as the broader climate change application needs of other DOE programs.
Staging and laser acceleration of ions in underdense plasma
NASA Astrophysics Data System (ADS)
Ting, Antonio; Hafizi, Bahman; Helle, Michael; Chen, Yu-Hsin; Gordon, Daniel; Kaganovich, Dmitri; Polyanskiy, Mikhail; Pogorelsky, Igor; Babzien, Markus; Miao, Chenlong; Dover, Nicholas; Najmudin, Zulfikar; Ettlinger, Oliver
2017-03-01
Accelerating ions from rest in a plasma requires extra considerations because of their heavy mass. Low phase velocity fields or quasi-electrostatic fields are often necessary, either by operating above or near the critical density or by applying other slow wave generating mechanisms. Solid targets have been a favorite and have generated many good results. High density gas targets have also been reported to produce energetic ions. It is interesting to consider acceleration of ions in laser-driven plasma configurations that will potentially allow continuous acceleration in multiple consecutive stages. The plasma will be derived from gaseous targets, producing plasma densities slightly below the critical plasma density (underdense) for the driving laser. Such a plasma is experimentally robust, being repeatable and relatively transparent to externally injected ions from a previous stage. When optimized, multiple stages of this underdense laser plasma acceleration mechanism can progressively accelerate the ions to a high final energy. For a light mass ion such as the proton, relativistic velocities could be reached, making it suitable for further acceleration by high phase velocity plasma accelerators to energies appropriate for High Energy Physics applications. Negatively charged ions such as antiprotons could be similarly accelerated in this multi-staged ion acceleration scheme.
Mass, charge, and energy separation by selective acceleration with a traveling potential hill
NASA Astrophysics Data System (ADS)
Tung, L. Schwager; Barr, W. L.; Lowder, R. S.; Post, R. F.
1996-10-01
A traveling electric potential hill has been used to generate an ion beam with an energy distribution that is mass dependent from a monoenergetic ion beam of mixed masses. This effect can be utilized as a novel method for mass separation applied to identification or enrichment of ions (e.g., of elements, isotopes, or molecules). This theory for mass-selective acceleration is presented here and is shown to be confirmed by experiment and by a time-dependent particle-in-cell computer simulation. Results show that monoenergetic ions with the particular mass of choice are accelerated by controlling the hill potential and the hill velocity. The hill velocity is typically 20%-30% faster than the ions to be accelerated. The ability of the hill to pickup a particular mass uses the fact that small kinetic energy differences in the lab frame appear much larger in the moving hill frame. Ions will gain energy from the approaching hill if their relative energy in the moving hill frame is less than the peak potential of the hill. The final energy of these accelerated ions can be several times the source energy, which facilitates energy filtering for mass purification or identification. If the hill potential is chosen to accelerate multiple masses, the heaviest mass will have the greatest final energy. Hence, choosing the appropriate hill potential and collector retarding voltage will isolate ions with the lightest, heaviest, or intermediate mass. In the experimental device, called a Solitron, purified 20Ne and 22Ne are extracted from a ribbon beam of neon that is originally composed of 20Ne:22Ne in the natural ratio of 91:9. The isotopic content of the processed beam is determined by measuring the energy distribution of the detected current. These results agree with the theory. In addition to mass selectivity, our theory can also be applied to the filtration of an ion beam according to charge state or energy. Because of this variety of properties, the Solitron is envisioned to have broad applications. The primary application is for the enrichment of stable isotopes for medical and industrial tracers. Other applications include mass analysis of unknown gases (atomic and molecular) and metals, extracting single charge states from a multiply charged beam, accelerating the high energy tail in a beam or plasma with a velocity distribution, and beam bunching.
KLYNAC: Compact linear accelerator with integrated power supply
DOE Office of Scientific and Technical Information (OSTI.GOV)
Malyzhenkov, Alexander
Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scienti c community is working towards improving the quality of the accelerated beam and its parameters while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype, resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RFmore » source, an accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simpli ed theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using particle-in-cell simulation studies for mono- resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.« less
Effects of TEA·HCl hardening accelerator on the workability of cement-based materials
NASA Astrophysics Data System (ADS)
Pan, Wenhao; Ding, Zhaoyang; Chen, Yanwen
2017-03-01
The aim of the test is to research the influence rules of TEA·HCl on the workability of cement paste and concrete. Based on the features of the new hardening accelerator, an experimental analysis system were established through different dosages of hardening accelerator, and the feasibility of such accelerator to satisfy the need of practical engineering was verified. The results show that adding of the hardening accelerator can accelerate the cement hydration, and what’s more, when the dosage was 0.04%, the setting time was the shortest while the initial setting time and final setting time were 130 min and 180 min, respectively. The initial fluidity of cement paste of adding accelerator was roughly equivalent compared with that of blank. After 30 min, fluidity loss would decrease with the dosage increasing, but fluidity may increase. The application of the hardening accelerator can make the early workability of concrete enhance, especially the slump loss of 30 min can improve more significantly. The bleeding rate of concrete significantly decreases after adding TEA·HCl. The conclusion is that the new hardening accelerator can meet the need of the workability of cement-based materials in the optimum dosage range.
Klynac: Compact Linear Accelerator with Integrated Power Supply
NASA Astrophysics Data System (ADS)
Malyzhenkov, A. V.
Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scientific community is working towards improving the quality of the accelerated beam and its parameters, while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype: resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RF source, accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simplified theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using Particle-In-Cell simulation studies for mono-resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.
Review of laser-driven ion sources and their applications.
Daido, Hiroyuki; Nishiuchi, Mamiko; Pirozhkov, Alexander S
2012-05-01
For many years, laser-driven ion acceleration, mainly proton acceleration, has been proposed and a number of proof-of-principle experiments have been carried out with lasers whose pulse duration was in the nanosecond range. In the 1990s, ion acceleration in a relativistic plasma was demonstrated with ultra-short pulse lasers based on the chirped pulse amplification technique which can provide not only picosecond or femtosecond laser pulse duration, but simultaneously ultra-high peak power of terawatt to petawatt levels. Starting from the year 2000, several groups demonstrated low transverse emittance, tens of MeV proton beams with a conversion efficiency of up to several percent. The laser-accelerated particle beams have a duration of the order of a few picoseconds at the source, an ultra-high peak current and a broad energy spectrum, which make them suitable for many, including several unique, applications. This paper reviews, firstly, the historical background including the early laser-matter interaction studies on energetic ion acceleration relevant to inertial confinement fusion. Secondly, we describe several implemented and proposed mechanisms of proton and/or ion acceleration driven by ultra-short high-intensity lasers. We pay special attention to relatively simple models of several acceleration regimes. The models connect the laser, plasma and proton/ion beam parameters, predicting important features, such as energy spectral shape, optimum conditions and scalings under these conditions for maximum ion energy, conversion efficiency, etc. The models also suggest possible ways to manipulate the proton/ion beams by tailoring the target and irradiation conditions. Thirdly, we review experimental results on proton/ion acceleration, starting with the description of driving lasers. We list experimental results and show general trends of parameter dependences and compare them with the theoretical predictions and simulations. The fourth topic includes a review of scientific, industrial and medical applications of laser-driven proton or ion sources, some of which have already been established, while the others are yet to be demonstrated. In most applications, the laser-driven ion sources are complementary to the conventional accelerators, exhibiting significantly different properties. Finally, we summarize the paper.
EuCARD2: enhanced accelerator research and development in Europe
NASA Astrophysics Data System (ADS)
Romaniuk, Ryszard S.
2013-10-01
Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. EuCARD2 is an European research project which will be realized during 2013-2017 inside the EC FP7 framework. The project concerns the development and coordination of European Accelerator Research and Development. The project is particularly important, to a number of domestic laboratories, due to some plans to build large accelerator infrastructure in Poland. Large accelerator infrastructure of fundamental and applied research character stimulates around it the development and industrial applications as well as biomedical of advanced accelerators, material research and engineering, cryo-technology, mechatronics, robotics, and in particular electronics - like networked measurement and control systems, sensors, computer systems, automation and control systems. The paper presents a digest of the European project EuCARD2 which is Enhanced European Coordination for Accelerator Research and Development. The paper presents a digest of the research results and assumptions in the domain of accelerator science and technology in Europe, shown during the final fourth annual meeting of the EuCARD - European Coordination of Accelerator R&D, and the kick-off meeting of the EuCARD2. There are debated a few basic groups of accelerator systems components like: measurement - control networks of large geometrical extent, multichannel systems for large amounts of metrological data acquisition, precision photonic networks of reference time, frequency and phase distribution, high field magnets, superconducting cavities, novel beam collimators, etc. The paper bases on the following materials: Internet and Intranet documents combined with EuCARD2, Description of Work FP7 EuCARD-2 DoW-312453, 2013-02-13, and discussions and preparatory materials worked on by Eucard-2 initiators.
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...
NASA Astrophysics Data System (ADS)
Avagyan, R. H.; Kerobyan, I. A.
2015-07-01
The final goal of the proposed project is the creation of a Complex of Accelerator Facilities at the Yerevan Physics Institute (CAF YerPhI) for nuclear physics basic researches, as well as for applied programs including boron neutron capture therapy (BNCT). The CAF will include the following facilities: Cyclotron C70, heavy material (uranium) target/ion source, mass-separator, LINAC1 (0.15-1.5 MeV/u) and LINAC2 (1.5-10 MeV/u). The delivered by C70 proton beams with energy 70 MeV will be used for investigations in the field of basic nuclear physics and with energy 30 MeV for use in applications.
Status of high temperature superconductor development for accelerator magnets
NASA Technical Reports Server (NTRS)
Hirabayashi, H.
1995-01-01
High temperature superconductors are still under development for various applications. As far as conductors for magnets are concerned, the development has just been started. Small coils wound by silver sheathed Bi-2212 and Bi-2223 oxide conductors have been reported by a few authors. Essential properties of high T(sub c) superconductors like pinning force, coherent length, intergrain coupling, weak link, thermal property, AC loss and mechanical strength are still not sufficiently understandable. In this talk, a review is given with comparison between the present achievement and the final requirement for high T(sub c) superconductors, which could be particularly used in accelerator magnets. Discussions on how to develop high T(sub c) superconductors for accelerator magnets are included with key parameters of essential properties. A proposal of how to make a prototype accelerator magnet with high T(sub c) superconductors with prospect for future development is also given.
2017-04-13
modelling code, a parallel benchmark , and a communication avoiding version of the QR algorithm. Further, several improvements to the OmpSs model were...movement; and a port of the dynamic load balancing library to OmpSs. Finally, several updates to the tools infrastructure were accomplished, including: an...OmpSs: a basic algorithm on image processing applications, a mini application representative of an ocean modelling code, a parallel benchmark , and a
ERIC Educational Resources Information Center
Dailey, K. Anne
Time-compressed speech (also called compressed speech, speeded speech, or accelerated speech) is an extension of the normal recording procedure for reproducing the spoken word. Compressed speech can be used to achieve dramatic reductions in listening time without significant loss in comprehension. The implications of such temporal reductions in…
Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zamora, Richard James; Voter, Arthur F.; Perez, Danny
Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less
Discrete event performance prediction of speculatively parallel temperature-accelerated dynamics
Zamora, Richard James; Voter, Arthur F.; Perez, Danny; ...
2016-12-01
Due to its unrivaled ability to predict the dynamical evolution of interacting atoms, molecular dynamics (MD) is a widely used computational method in theoretical chemistry, physics, biology, and engineering. Despite its success, MD is only capable of modeling time scales within several orders of magnitude of thermal vibrations, leaving out many important phenomena that occur at slower rates. The Temperature Accelerated Dynamics (TAD) method overcomes this limitation by thermally accelerating the state-to-state evolution captured by MD. Due to the algorithmically complex nature of the serial TAD procedure, implementations have yet to improve performance by parallelizing the concurrent exploration of multiplemore » states. Here we utilize a discrete event-based application simulator to introduce and explore a new Speculatively Parallel TAD (SpecTAD) method. We investigate the SpecTAD algorithm, without a full-scale implementation, by constructing an application simulator proxy (SpecTADSim). Finally, following this method, we discover that a nontrivial relationship exists between the optimal SpecTAD parameter set and the number of CPU cores available at run-time. Furthermore, we find that a majority of the available SpecTAD boost can be achieved within an existing TAD application using relatively simple algorithm modifications.« less
High power ring methods and accelerator driven subcritical reactor application
DOE Office of Scientific and Technical Information (OSTI.GOV)
Tahar, Malek Haj
2016-08-07
High power proton accelerators allow providing, by spallation reaction, the neutron fluxes necessary in the synthesis of fissile material, starting from Uranium 238 or Thorium 232. This is the basis of the concept of sub-critical operation of a reactor, for energy production or nuclear waste transmutation, with the objective of achieving cleaner, safer and more efficient process than today’s technologies allow. Designing, building and operating a proton accelerator in the 500-1000 MeV energy range, CW regime, MW power class still remains a challenge nowadays. There is a limited number of installations at present achieving beam characteristics in that class, e.g.,more » PSI in Villigen, 590 MeV CW beam from a cyclotron, SNS in Oakland, 1 GeV pulsed beam from a linear accelerator, in addition to projects as the ESS in Europe, a 5 MW beam from a linear accelerator. Furthermore, coupling an accelerator to a sub-critical nuclear reactor is a challenging proposition: some of the key issues/requirements are the design of a spallation target to withstand high power densities as well as ensure the safety of the installation. These two domains are the grounds of the PhD work: the focus is on the high power ring methods in the frame of the KURRI FFAG collaboration in Japan: upgrade of the installation towards high intensity is crucial to demonstrate the high beam power capability of FFAG. Thus, modeling of the beam dynamics and benchmarking of different codes was undertaken to validate the simulation results. Experimental results revealed some major losses that need to be understood and eventually overcome. By developing analytical models that account for the field defects, one identified major sources of imperfection in the design of scaling FFAG that explain the important tune variations resulting in the crossing of several betatron resonances. A new formula is derived to compute the tunes and properties established that characterize the effect of the field imperfections on the transverse beam dynamics. The results obtained allow to develop a correction scheme to minimize the tune variations of the FFAG. This is the cornerstone of a new fixed tune non-scaling FFAG that represents a potential candidate for high power applications. As part of the developments towards high power at the KURRI FFAG, beam dynamics studies have to account for space charge effects. In that framework, models have been installed in the tracking code ZGOUBI to account for the self-interaction of the particles in the accelerator. Application to the FFAG studies is shown. Finally, one focused on the ADSR concept as a candidate to solve the problem of nuclear waste. In order to establish the accelerator requirements, one compared the performance of ADSR with other conventional critical reactors by means of the levelized cost of energy. A general comparison between the different accelerator technologies that can satisfy these requirements is finally presented. In summary, the main drawback of the ADSR technology is the high Levelized Cost Of Energy compared to other advanced reactor concepts that do not employ an accelerator. Nowadays, this is a show-stopper for any industrial application aiming at producing energy (without dealing with the waste problem). Besides, the reactor is not intrinsically safer than critical reactor concepts, given the complexity of managing the target interface between the accelerator and the reactor core.« less
Overview of recent trends and developments for BPM systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wendt, M.; /Fermilab
2011-08-01
Beam position monitoring (BPM) systems are the workhorse of beam diagnostics for almost any kind of charged particle accelerator: linear, circular or transport-lines, operating with leptons, hadrons or heavy ions. BPMs are essential for beam commissioning, accelerator fault analysis and trouble shooting, machine optics, as well as lattice measurements, and finally, for accelerator optimization, in order to achieve the ultimate beam quality. This presentation summarizes the efforts of the beam instrumentation community on recent developments and advances on BPM technologies, i.e. BPM pickup monitors and front-end electronics (analog and digital). Principles, examples, and state-of-the-art status on various BPM techniques, servingmore » hadron and heavy ion machines, sync light synchrotron's, as well as electron linacs for FEL or HEP applications are outlined.« less
Design, Construction, and Test of a 473 MHZ Four - Cavity Rfq.
NASA Astrophysics Data System (ADS)
Kazimi, Reza
1992-01-01
An RFQ accelerator using the new four-rod cavity design has been fabricated and successfully tested at Texas Accelerator Center. The RFQ is designed to accelerate a 10 mA H^- ion beam from 30 keV to 500 keV with the operating frequency of 473 MHz. This new type of RFQ structure not only promises simplicity of design, construction, and operation, but also can be manufactured to operate at higher frequencies than previously achieved by other four-rod type RFQs. Combination of simplicity and compactness due to higher operating frequencies (400 to 500 MHz) makes the design desirable for injector of proton accelerators, medical linear accelerators, and variety of other applications. This dissertation presents the steps I went through in inventing, developing, and experimentally testing this new RFQ design. First an introduction to accelerators is given, and the basic accelerator physics terminologies are defined. The principles of operations of the RFQs are described, and the theory behind new type of RFQ structure is explained. Then the beam dynamics and cavity design of the RFQ are presented. Finally, the mechanical design and construction procedure are discussed, and experimental results of rf tests and actual H ^- beam test are given.
Cyber Technology for Materials and Structures in Aeronautics and Aerospace
NASA Technical Reports Server (NTRS)
Pipes, R. Byron
2002-01-01
The evolution of composites applications in aeronautics from 1970 to the present is discussed. The barriers and challenges to economic application and to certification are presented and recommendations for accelerated development are outlined. The potential benefits of emerging technologies to aeronautics and their foundation in composite materials are described and the resulting benefits in vehicle take off gross weight are quantified. Finally, a 21st century vision for aeronautics in which human mobility is increased by an order of magnitude is articulated.
Can superhorizon cosmological perturbations explain the acceleration of the universe?
NASA Astrophysics Data System (ADS)
Hirata, Christopher M.; Seljak, Uroš
2005-10-01
We investigate the recent suggestions by Barausse et al. and Kolb et al. that the acceleration of the universe could be explained by large superhorizon fluctuations generated by inflation. We show that no acceleration can be produced by this mechanism. We begin by showing how the application of Raychaudhuri equation to inhomogeneous cosmologies results in several “no go” theorems for accelerated expansion. Next we derive an exact solution for a specific case of initial perturbations, for which application of the Kolb et al. expressions leads to an acceleration, while the exact solution reveals that no acceleration is present. We show that the discrepancy can be traced to higher-order terms that were dropped in the Kolb et al. analysis. We proceed with the analysis of initial value formulation of general relativity to argue that causality severely limits what observable effects can be derived from superhorizon perturbations. By constructing a Riemann normal coordinate system on initial slice we show that no infrared divergence terms arise in this coordinate system. Thus any divergences found previously can be eliminated by a local rescaling of coordinates and are unobservable. We perform an explicit analysis of the variance of the deceleration parameter for the case of single-field inflation using usual coordinates and show that the infrared-divergent terms found by Barausse et al. and Kolb et al. cancel against several additional terms not considered in their analysis. Finally, we argue that introducing isocurvature perturbations does not alter our conclusion that the accelerating expansion of the universe cannot be explained by superhorizon modes.
Electromagnetic and geometric characterization of accelerated ion beams by laser ablation
NASA Astrophysics Data System (ADS)
Nassisi, V.; Velardi, L.; Side, D. Delle
2013-05-01
Laser ion sources offer the possibility to get ion beam useful to improve particle accelerators. Pulsed lasers at intensities of the order of 108 W/cm2 and of ns pulse duration, interacting with solid matter in vacuum, produce plasma of high temperature and density. The charge state distribution of the plasma generates high electric fields which accelerate ions along the normal to the target surface. The energy of emitted ions has a Maxwell-Boltzmann distribution which depends on the ion charge state. To increase the ion energy, a post-acceleration system can be employed by means of high voltage power supplies of about 100 kV. The post acceleration system results to be a good method to obtain high ion currents by a not expensive system and the final ion beams find interesting applications in the field of the ion implantation, scientific applications and industrial use. In this work we compare the electromagnetic and geometric properties, like emittance, of the beams delivered by pure Cu, Y and Ag targets. The characterization of the plasma was performed by a Faraday cup for the electromagnetic characteristics, whereas a pepper pot system was used for the geometric ones. At 60 kV accelerating voltage the three examined ion bunches get a current peak of 5.5, 7.3 and 15 mA, with a normalized beam emittance of 0.22, 0.12 and 0.09 π mm mrad for the targets of Cu, Y, and Ag, respectively.
NASA Astrophysics Data System (ADS)
Fiandrotti, Attilio; Fosson, Sophie M.; Ravazzi, Chiara; Magli, Enrico
2018-04-01
Compressive sensing promises to enable bandwidth-efficient on-board compression of astronomical data by lifting the encoding complexity from the source to the receiver. The signal is recovered off-line, exploiting GPUs parallel computation capabilities to speedup the reconstruction process. However, inherent GPU hardware constraints limit the size of the recoverable signal and the speedup practically achievable. In this work, we design parallel algorithms that exploit the properties of circulant matrices for efficient GPU-accelerated sparse signals recovery. Our approach reduces the memory requirements, allowing us to recover very large signals with limited memory. In addition, it achieves a tenfold signal recovery speedup thanks to ad-hoc parallelization of matrix-vector multiplications and matrix inversions. Finally, we practically demonstrate our algorithms in a typical application of circulant matrices: deblurring a sparse astronomical image in the compressed domain.
Terrestrial Applications of a Nano-g Accelerometer
NASA Technical Reports Server (NTRS)
Hartley, Frank T.
1996-01-01
The ultra-sensitive accelerometer, developed for NASA to monitor the microgravity environments of Space Shuttle, five orbiters and Space Station, needed to measure accelerations up to 10 mg with an absolute accuracy of 10 nano-g (10(exp -8)g) for at least two orbits (10(exp 4) seconds) to resolve accelerations associated with orbital drag. Also, the accelerometers needed to have less than 10(exp -9) F.S. off-axis sensitivity; to be thermally and magnetically inert; to be immune to quiescent shock, and to have an in-situ calibration capability. Multi-axis compact seismometers, designs that have twelve decades of dynamic range will be described. Density profilometers, precision gradiometers, gyros and vibration isolation designs and applications will be discussed. Finally, examples of transformations of the accelerometer into sensitive anemometers and imaging spectrometers will be presented.
Considerations on the Use of Custom Accelerators for Big Data Analytics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Castellana, Vito G.; Tumeo, Antonino; Minutoli, Marco
Accelerators, including Graphic Processing Units (GPUs) for gen- eral purpose computation, many-core designs with wide vector units (e.g., Intel Phi), have become a common component of many high performance clusters. The appearance of more stable and reliable tools tools that can automatically convert code written in high-level specifications with annotations (such as C or C++) to hardware de- scription languages (High-Level Synthesis - HLS), is also setting the stage for a broader use of reconfigurable devices (e.g., Field Pro- grammable Gate Arrays - FPGAs) in high performance system for the implementation of custom accelerators, helped by the fact that newmore » processors include advanced cache-coherent interconnects for these components. In this chapter, we briefly survey the status of the use of accelerators in high performance systems targeted at big data analytics applications. We argue that, although the progress in the use of accelerators for this class of applications has been sig- nificant, differently from scientific simulations there still are gaps to close. This is particularly true for the ”irregular” behaviors exhibited by no-SQL, graph databases. We focus our attention on the limits of HLS tools for data analytics and graph methods, and discuss a new architectural template that better fits the requirement of this class of applications. We validate the new architectural templates by mod- ifying the Graph Engine for Multithreaded System (GEMS) frame- work to support accelerators generated with such a methodology, and testing with queries coming from the Lehigh University Benchmark (LUBM). The architectural template enables better supporting the task and memory level parallelism present in graph methods by sup- porting a new control model and a enhanced memory interface. We show that out solution allows generating parallel accelerators, pro- viding speed ups with respect to conventional HLS flows. We finally draw conclusions and present a perspective on the use of reconfig- urable devices and Design Automation tools for data analytics.« less
An accelerated proximal augmented Lagrangian method and its application in compressive sensing.
Sun, Min; Liu, Jing
2017-01-01
As a first-order method, the augmented Lagrangian method (ALM) is a benchmark solver for linearly constrained convex programming, and in practice some semi-definite proximal terms are often added to its primal variable's subproblem to make it more implementable. In this paper, we propose an accelerated PALM with indefinite proximal regularization (PALM-IPR) for convex programming with linear constraints, which generalizes the proximal terms from semi-definite to indefinite. Under mild assumptions, we establish the worst-case [Formula: see text] convergence rate of PALM-IPR in a non-ergodic sense. Finally, numerical results show that our new method is feasible and efficient for solving compressive sensing.
Application of Plasma Waveguides to High Energy Accelerators
DOE Office of Scientific and Technical Information (OSTI.GOV)
Milchberg, Howard M
2013-03-30
The eventual success of laser-plasma based acceleration schemes for high-energy particle physics will require the focusing and stable guiding of short intense laser pulses in reproducible plasma channels. For this goal to be realized, many scientific issues need to be addressed. These issues include an understanding of the basic physics of, and an exploration of various schemes for, plasma channel formation. In addition, the coupling of intense laser pulses to these channels and the stable propagation of pulses in the channels require study. Finally, new theoretical and computational tools need to be developed to aid in the design and analysismore » of experiments and future accelerators. Here we propose a 3-year renewal of our combined theoretical and experimental program on the applications of plasma waveguides to high-energy accelerators. During the past grant period we have made a number of significant advances in the science of laser-plasma based acceleration. We pioneered the development of clustered gases as a new highly efficient medium for plasma channel formation. Our contributions here include theoretical and experimental studies of the physics of cluster ionization, heating, explosion, and channel formation. We have demonstrated for the first time the generation of and guiding in a corrugated plasma waveguide. The fine structure demonstrated in these guides is only possible with cluster jet heating by lasers. The corrugated guide is a slow wave structure operable at arbitrarily high laser intensities, allowing direct laser acceleration, a process we have explored in detail with simulations. The development of these guides opens the possibility of direct laser acceleration, a true miniature analogue of the SLAC RF-based accelerator. Our theoretical studies during this period have also contributed to the further development of the simulation codes, Wake and QuickPIC, which can be used for both laser driven and beam driven plasma based acceleration schemes. We will continue our development of advanced simulation tools by modifying the QuickPIC algorithm to allow for the simulation of plasma particle pick-up by the wake fields. We have also performed extensive simulations of plasma slow wave structures for efficient THz generation by guided laser beams or accelerated electron beams. We will pursue experimental studies of direct laser acceleration, and THz generation by two methods, ponderomotive-induced THz polarization, and THz radiation by laser accelerated electron beams. We also plan to study both conventional and corrugated plasma channels using our new 30 TW in our new lab facilities. We will investigate production of very long hydrogen plasma waveguides (5 cm). We will study guiding at increasing power levels through the onset of laser-induced cavitation (bubble regime) to assess the role played by the preformed channel. Experiments in direct acceleration will be performed, using laser plasma wakefields as the electron injector. Finally, we will use 2-colour ionization of gases as a high frequency THz source (<60 THz) in order for femtosecond measurements of low plasma densities in waveguides and beams.« less
Quantum Accelerators for High-performance Computing Systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Humble, Travis S.; Britt, Keith A.; Mohiyaddin, Fahd A.
We define some of the programming and system-level challenges facing the application of quantum processing to high-performance computing. Alongside barriers to physical integration, prominent differences in the execution of quantum and conventional programs challenges the intersection of these computational models. Following a brief overview of the state of the art, we discuss recent advances in programming and execution models for hybrid quantum-classical computing. We discuss a novel quantum-accelerator framework that uses specialized kernels to offload select workloads while integrating with existing computing infrastructure. We elaborate on the role of the host operating system to manage these unique accelerator resources, themore » prospects for deploying quantum modules, and the requirements placed on the language hierarchy connecting these different system components. We draw on recent advances in the modeling and simulation of quantum computing systems with the development of architectures for hybrid high-performance computing systems and the realization of software stacks for controlling quantum devices. Finally, we present simulation results that describe the expected system-level behavior of high-performance computing systems composed from compute nodes with quantum processing units. We describe performance for these hybrid systems in terms of time-to-solution, accuracy, and energy consumption, and we use simple application examples to estimate the performance advantage of quantum acceleration.« less
A conceptual framework for evaluating variable speed generator options for wind energy applications
NASA Technical Reports Server (NTRS)
Reddoch, T. W.; Lipo, T. A.; Hinrichsen, E. N.; Hudson, T. L.; Thomas, R. J.
1995-01-01
Interest in variable speed generating technology has accelerated as greater emphasis on overall efficiency and superior dynamic and control properties in wind-electric generating systems are sought. This paper reviews variable speed technology options providing advantages and disadvantages of each. Furthermore, the dynamic properties of variable speed systems are contrasted with synchronous operation. Finally, control properties of variable speed systems are examined.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Panuganti, SriHarsha
Production of quality electron bunches using e cient ways of generation is a crucial aspect of accelerator technology. Radio frequency electron guns are widely used to generate and rapidly accelerate electron beams to relativistic energies. In the current work, we primarily study the charge generation processes of photoemission and eld emission inside an RF gun installed at Fermilab's High Brightness Electron Source Laboratory (HBESL). Speci cally, we study and characterize second-order nonlinear photoemission from a Cesium Telluride (Cs 2Te) semiconductor photocathode, and eld emission from carbon based cathodes including diamond eld emission array (DFEA) and carbon nanotube (CNT) cathodes locatedmore » in the RF gun's cavity. Finally, we discuss the application experiments conducted at the facility to produce soft x-rays via inverse Compton scattering (ICS), and to generate uniformly lled ellipsoidal bunches and temporally shaped electron beams from the Cs 2Te photocathode.« less
1984-08-01
COLLFCTIVF PAPTTCLE ACCELERATOR VIA NUMERICAL MODFLINC WITH THF MAGIC CODE Robert 1. Darker Auqust 19F4 Final Report for Period I April. qI84 - 30...NUMERICAL MODELING WITH THE MAGIC CODE Robert 3. Barker August 1984 Final Report for Period 1 April 1984 - 30 September 1984 Prepared for: Scientific...Collective Final Report Particle Accelerator VIA Numerical Modeling with April 1 - September-30, 1984 MAGIC Code. 6. PERFORMING ORG. REPORT NUMBER MRC/WDC-R
A compact linear accelerator based on a scalable microelectromechanical-system RF-structure
Persaud, A.; Ji, Q.; Feinberg, E.; ...
2017-06-08
Here, a new approach for a compact radio-frequency (RF) accelerator structure is presented. The new accelerator architecture is based on the Multiple Electrostatic Quadrupole Array Linear Accelerator (MEQALAC) structure that was first developed in the 1980s. The MEQALAC utilized RF resonators producing the accelerating fields and providing for higher beam currents through parallel beamlets focused using arrays of electrostatic quadrupoles (ESQs). While the early work obtained ESQs with lateral dimensions on the order of a few centimeters, using a printed circuit board (PCB), we reduce the characteristic dimension to the millimeter regime, while massively scaling up the potential number ofmore » parallel beamlets. Using Microelectromechanical systems scalable fabrication approaches, we are working on further red ucing the characteristic dimension to the sub-millimeter regime. The technology is based on RF-acceleration components and ESQs implemented in the PCB or silicon wafers where each beamlet passes through beam apertures in the wafer. The complete accelerator is then assembled by stacking these wafers. This approach has the potential for fast and inexpensive batch fabrication of the components and flexibility in system design for application specific beam energies and currents. For prototyping the accelerator architecture, the components have been fabricated using the PCB. In this paper, we present proof of concept results of the principal components using the PCB: RF acceleration and ESQ focusing. Finally, ongoing developments on implementing components in silicon and scaling of the accelerator technology to high currents and beam energies are discussed.« less
Acceleration of GPU-based Krylov solvers via data transfer reduction
Anzt, Hartwig; Tomov, Stanimire; Luszczek, Piotr; ...
2015-04-08
Krylov subspace iterative solvers are often the method of choice when solving large sparse linear systems. At the same time, hardware accelerators such as graphics processing units continue to offer significant floating point performance gains for matrix and vector computations through easy-to-use libraries of computational kernels. However, as these libraries are usually composed of a well optimized but limited set of linear algebra operations, applications that use them often fail to reduce certain data communications, and hence fail to leverage the full potential of the accelerator. In this study, we target the acceleration of Krylov subspace iterative methods for graphicsmore » processing units, and in particular the Biconjugate Gradient Stabilized solver that significant improvement can be achieved by reformulating the method to reduce data-communications through application-specific kernels instead of using the generic BLAS kernels, e.g. as provided by NVIDIA’s cuBLAS library, and by designing a graphics processing unit specific sparse matrix-vector product kernel that is able to more efficiently use the graphics processing unit’s computing power. Furthermore, we derive a model estimating the performance improvement, and use experimental data to validate the expected runtime savings. Finally, considering that the derived implementation achieves significantly higher performance, we assert that similar optimizations addressing algorithm structure, as well as sparse matrix-vector, are crucial for the subsequent development of high-performance graphics processing units accelerated Krylov subspace iterative methods.« less
Emittance preservation in plasma-based accelerators with ion motion
Benedetti, C.; Schroeder, C. B.; Esarey, E.; ...
2017-11-01
In a plasma-accelerator-based linear collider, the density of matched, low-emittance, high-energy particle bunches required for collider applications can be orders of magnitude above the background ion density, leading to ion motion, perturbation of the focusing fields, and, hence, to beam emittance growth. By analyzing the response of the background ions to an ultrahigh density beam, analytical expressions, valid for nonrelativistic ion motion, are derived for the transverse wakefield and for the final (i.e., after saturation) bunch emittance. Analytical results are validated against numerical modeling. Initial beam distributions are derived that are equilibrium solutions, which require head-to-tail bunch shaping, enabling emittancemore » preservation with ion motion.« less
NASA Astrophysics Data System (ADS)
Vainshtein, Igor; Baruch, Shlomi; Regev, Itai; Segal, Victor; Filis, Avishai; Riabzev, Sergey
2018-05-01
The growing demand for EO applications that work around the clock 24hr/7days a week, such as in border surveillance systems, emphasizes the need for a highly reliable cryocooler having increased operational availability and optimized system's Integrated Logistic Support (ILS). In order to meet this need, RICOR developed linear and rotary cryocoolers which achieved successfully this goal. Cryocoolers MTTF was analyzed by theoretical reliability evaluation methods, demonstrated by normal and accelerated life tests at Cryocooler level and finally verified by field data analysis derived from Cryocoolers operating at system level. The following paper reviews theoretical reliability analysis methods together with analyzing reliability test results derived from standard and accelerated life demonstration tests performed at Ricor's advanced reliability laboratory. As a summary for the work process, reliability verification data will be presented as a feedback from fielded systems.
PARTICLE ACCELERATOR AND METHOD OF CONTROLLING THE TEMPERATURE THEREOF
Neal, R.B.; Gallagher, W.J.
1960-10-11
A method and means for controlling the temperature of a particle accelerator and more particularly to the maintenance of a constant and uniform temperature throughout a particle accelerator is offered. The novel feature of the invention resides in the provision of two individual heating applications to the accelerator structure. The first heating application provided is substantially a duplication of the accelerator heat created from energization, this first application being employed only when the accelerator is de-energized thereby maintaining the accelerator temperature constant with regard to time whether the accelerator is energized or not. The second heating application provided is designed to add to either the first application or energization heat in a manner to create the same uniform temperature throughout all portions of the accelerator.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Church, M.; Edwards, H.; Harms, E.
2013-10-01
Fermilab is the nation’s particle physics laboratory, supported by the DOE Office of High Energy Physics (OHEP). Fermilab is a world leader in accelerators, with a demonstrated track-record— spanning four decades—of excellence in accelerator science and technology. We describe the significant opportunity to complete, in a highly leveraged manner, a unique accelerator research facility that supports the broad strategic goals in accelerator science and technology within the OHEP. While the US accelerator-based HEP program is oriented toward the Intensity Frontier, which requires modern superconducting linear accelerators and advanced highintensity storage rings, there are no accelerator test facilities that support themore » accelerator science of the Intensity Frontier. Further, nearly all proposed future accelerators for Discovery Science will rely on superconducting radiofrequency (SRF) acceleration, yet there are no dedicated test facilities to study SRF capabilities for beam acceleration and manipulation in prototypic conditions. Finally, there are a wide range of experiments and research programs beyond particle physics that require the unique beam parameters that will only be available at Fermilab’s Advanced Superconducting Test Accelerator (ASTA). To address these needs we submit this proposal for an Accelerator R&D User Facility at ASTA. The ASTA program is based on the capability provided by an SRF linac (which provides electron beams from 50 MeV to nearly 1 GeV) and a small storage ring (with the ability to store either electrons or protons) to enable a broad range of beam-based experiments to study fundamental limitations to beam intensity and to develop transformative approaches to particle-beam generation, acceleration and manipulation which cannot be done elsewhere. It will also establish a unique resource for R&D towards Energy Frontier facilities and a test-bed for SRF accelerators and high brightness beam applications in support of the OHEP mission of Accelerator Stewardship.« less
Implementing Molecular Dynamics for Hybrid High Performance Computers - 1. Short Range Forces
DOE Office of Scientific and Technical Information (OSTI.GOV)
Brown, W Michael; Wang, Peng; Plimpton, Steven J
The use of accelerators such as general-purpose graphics processing units (GPGPUs) have become popular in scientific computing applications due to their low cost, impressive floating-point capabilities, high memory bandwidth, and low electrical power requirements. Hybrid high performance computers, machines with more than one type of floating-point processor, are now becoming more prevalent due to these advantages. In this work, we discuss several important issues in porting a large molecular dynamics code for use on parallel hybrid machines - 1) choosing a hybrid parallel decomposition that works on central processing units (CPUs) with distributed memory and accelerator cores with shared memory,more » 2) minimizing the amount of code that must be ported for efficient acceleration, 3) utilizing the available processing power from both many-core CPUs and accelerators, and 4) choosing a programming model for acceleration. We present our solution to each of these issues for short-range force calculation in the molecular dynamics package LAMMPS. We describe algorithms for efficient short range force calculation on hybrid high performance machines. We describe a new approach for dynamic load balancing of work between CPU and accelerator cores. We describe the Geryon library that allows a single code to compile with both CUDA and OpenCL for use on a variety of accelerators. Finally, we present results on a parallel test cluster containing 32 Fermi GPGPUs and 180 CPU cores.« less
Van Atta, C.M.; Beringer, R.; Smith, L.
1959-01-01
A linear accelerator of heavy ions is described. The basic contributions of the invention consist of a method and apparatus for obtaining high energy particles of an element with an increased charge-to-mass ratio. The method comprises the steps of ionizing the atoms of an element, accelerating the resultant ions to an energy substantially equal to one Mev per nucleon, stripping orbital electrons from the accelerated ions by passing the ions through a curtain of elemental vapor disposed transversely of the path of the ions to provide a second charge-to-mass ratio, and finally accelerating the resultant stripped ions to a final energy of at least ten Mev per nucleon.
Ekerfelt, Henrik; Hansson, Martin; Gallardo González, Isabel; Davoine, Xavier; Lundh, Olle
2017-09-25
One challenge in the development of laser wakefield accelerators is to demonstrate sufficient control and reproducibility of the parameters of the generated bunches of accelerated electrons. Here we report on a numerical study, where we demonstrate that trapping using density down-ramps allows for tuning of several electron bunch parameters by varying the properties of the density down-ramp. We show that the electron bunch length is determined by the difference in density before and after the ramp. Furthermore, the transverse emittance of the bunch is controlled by the steepness of the ramp. Finally, the amount of trapped charge depends both on the density difference and on the steepness of the ramp. We emphasize that both parameters of the density ramp are feasible to vary experimentally. We therefore conclude that this tunable electron accelerator makes it suitable for a wide range of applications, from those requiring short pulse length and low emittance, such as the free-electron lasers, to those requiring high-charge, large-emittance bunches to maximize betatron X-ray generation.
Li, Jian; Bloch, Pavel; Xu, Jing; Sarunic, Marinko V; Shannon, Lesley
2011-05-01
Fourier domain optical coherence tomography (FD-OCT) provides faster line rates, better resolution, and higher sensitivity for noninvasive, in vivo biomedical imaging compared to traditional time domain OCT (TD-OCT). However, because the signal processing for FD-OCT is computationally intensive, real-time FD-OCT applications demand powerful computing platforms to deliver acceptable performance. Graphics processing units (GPUs) have been used as coprocessors to accelerate FD-OCT by leveraging their relatively simple programming model to exploit thread-level parallelism. Unfortunately, GPUs do not "share" memory with their host processors, requiring additional data transfers between the GPU and CPU. In this paper, we implement a complete FD-OCT accelerator on a consumer grade GPU/CPU platform. Our data acquisition system uses spectrometer-based detection and a dual-arm interferometer topology with numerical dispersion compensation for retinal imaging. We demonstrate that the maximum line rate is dictated by the memory transfer time and not the processing time due to the GPU platform's memory model. Finally, we discuss how the performance trends of GPU-based accelerators compare to the expected future requirements of FD-OCT data rates.
Stainless Steel Corrosion Studies Final Report: FY17 End of-Year
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kelly, Daniel; Milenski, Helen Marie; Martinez, Destiny
Two materials are being considered in applications requiring their contact against stainless steel surfaces. These materials include the solvent methyl ethyl ketone (MEK), and the polymer neoprene (polychloroprene). There is concern that contact of these materials with stainless steel substrates may lead to corrosion. To address these concerns we have undertaken corrosion studies under conditions expected to be more aggressive than in intended applications. These conditions include elevated temperature and humidity, and submersion and suspension in solvent vapors, in an attempt to accelerate any potential deleterious interactions. Corrosion rates below 0.1 mpy have historically been deemed INSIGNIFICANT from a WRmore » Production standpoint; corresponding guidelines for non-production applications are lacking.« less
Recent Developments and Applications of Radiation/Detection Technology in Tsinghua University
NASA Astrophysics Data System (ADS)
Kang, Ke-Jun
2010-03-01
Nuclear technology applications have been very important research fields in Tsinghua University (THU) for more than 50 years. This paper describes two major directions and related projects running in THU concerning nuclear technology applications for radiation imaging and nuclear technology applications for astrophysics. Radiation imaging is a significant application of nuclear technology for all kinds of real world needs including security inspections, anti-smuggling operations, and medicine. The current improved imaging systems give much higher quality radiation images. THU has produced accelerating tubes for both industrial and medical accelerators with energy levels ranging from 2.5˜20Mev. Detectors have been produced for medical and industrial imaging as well as for high energy physics experiments such as the MRPC with fast time and position resolutions. DR and CT systems for radiation imaging systems have been continuously improved with new system designs and improved algorithms for image reconstruction and processing. Two important new key initiatives are the dual-energy radiography and dual-energy CT systems. Dual-energy CT imaging improves material discrimination by providing both the electron density and the atomic number distribution of scanned objects. Finally, this paper also introduces recent developments related to the hard X-ray modulation telescope (HXMT) provided by THU.
Tao, Li; Zhu, Kun; Zhu, Jungao; Xu, Xiaohan; Lin, Chen; Ma, Wenjun; Lu, Haiyang; Zhao, Yanying; Lu, Yuanrong; Chen, Jia-Er; Yan, Xueqing
2017-07-07
With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.
TADSim: Discrete Event-based Performance Prediction for Temperature Accelerated Dynamics
Mniszewski, Susan M.; Junghans, Christoph; Voter, Arthur F.; ...
2015-04-16
Next-generation high-performance computing will require more scalable and flexible performance prediction tools to evaluate software--hardware co-design choices relevant to scientific applications and hardware architectures. Here, we present a new class of tools called application simulators—parameterized fast-running proxies of large-scale scientific applications using parallel discrete event simulation. Parameterized choices for the algorithmic method and hardware options provide a rich space for design exploration and allow us to quickly find well-performing software--hardware combinations. We demonstrate our approach with a TADSim simulator that models the temperature-accelerated dynamics (TAD) method, an algorithmically complex and parameter-rich member of the accelerated molecular dynamics (AMD) family ofmore » molecular dynamics methods. The essence of the TAD application is captured without the computational expense and resource usage of the full code. We accomplish this by identifying the time-intensive elements, quantifying algorithm steps in terms of those elements, abstracting them out, and replacing them by the passage of time. We use TADSim to quickly characterize the runtime performance and algorithmic behavior for the otherwise long-running simulation code. We extend TADSim to model algorithm extensions, such as speculative spawning of the compute-bound stages, and predict performance improvements without having to implement such a method. Validation against the actual TAD code shows close agreement for the evolution of an example physical system, a silver surface. Finally, focused parameter scans have allowed us to study algorithm parameter choices over far more scenarios than would be possible with the actual simulation. This has led to interesting performance-related insights and suggested extensions.« less
NASA Astrophysics Data System (ADS)
Qiu, Feng; Michizono, Shinichiro; Miura, Takako; Matsumoto, Toshihiro; Liu, Na; Wibowo, Sigit Basuki
2018-03-01
A Low-level radio-frequency (LLRF) control systems is required to regulate the rf field in the rf cavity used for beam acceleration. As the LLRF system is usually complex, testing of the basic functions or control algorithms of this system in real time and in advance of beam commissioning is strongly recommended. However, the equipment necessary to test the LLRF system, such as superconducting cavities and high-power rf sources, is very expensive; therefore, we have developed a field-programmable gate array (FPGA)-based cavity simulator as a substitute for real rf cavities. Digital models of the cavity and other rf systems are implemented in the FPGA. The main components include cavity baseband models for the fundamental and parasitic modes, a mechanical model of the Lorentz force detuning, and a model of the beam current. Furthermore, in our simulator, the disturbance model used to simulate the power-supply ripples and microphonics is also carefully considered. Based on the presented cavity simulator, we have established an LLRF system test bench that can be applied to different cavity operational conditions. The simulator performance has been verified by comparison with real cavities in KEK accelerators. In this paper, the development and implementation of this cavity simulator is presented first, and the LLRF test bench based on the presented simulator is constructed. The results are then compared with those for KEK accelerators. Finally, several LLRF applications of the cavity simulator are illustrated.
Matsunami, K; Satake, H; Konishi, T
1998-07-01
Sustained hyper-gravity acceleration, particularly along the long axis of the body of animals or man (Gz), produces significant mal-effects on subjects, and hence it has been well studied, The most common syndromes of Gz application were cardio-vascular de-conditioning, and black-out, red-out, and loss of consciousness, which finally lead subjects into death. However, in most previous studies, the duration of applied Gz was rather short. In the present experiments, we can use longer duration of 1000 seconds. In addition, recent technological innovation make it possible to record directly local cerebral blood flow at a target cortical area with a Laser Doppler flow meter. We used this innovated method to measure local cerebral blood flow of rats in relation to visual evoked potentials (VEPs) under hyper-Gz acceleration. Also we recorded cardio-vascular parameters like heart rate from ECG, systolic and diastolic blood pressure and correlated them with cerebral blood flow and VEPs.
Laser beam coupling with capillary discharge plasma for laser wakefield acceleration applications
NASA Astrophysics Data System (ADS)
Bagdasarov, G. A.; Sasorov, P. V.; Gasilov, V. A.; Boldarev, A. S.; Olkhovskaya, O. G.; Benedetti, C.; Bulanov, S. S.; Gonsalves, A.; Mao, H.-S.; Schroeder, C. B.; van Tilborg, J.; Esarey, E.; Leemans, W. P.; Levato, T.; Margarone, D.; Korn, G.
2017-08-01
One of the most robust methods, demonstrated to date, of accelerating electron beams by laser-plasma sources is the utilization of plasma channels generated by the capillary discharges. Although the spatial structure of the installation is simple in principle, there may be some important effects caused by the open ends of the capillary, by the supplying channels etc., which require a detailed 3D modeling of the processes. In the present work, such simulations are performed using the code MARPLE. First, the process of capillary filling with cold hydrogen before the discharge is fired, through the side supply channels is simulated. Second, the simulation of the capillary discharge is performed with the goal to obtain a time-dependent spatial distribution of the electron density near the open ends of the capillary as well as inside the capillary. Finally, to evaluate the effectiveness of the beam coupling with the channeling plasma wave guide and of the electron acceleration, modeling of the laser-plasma interaction was performed with the code INF&RNO.
A strong-focusing 800 MeV cyclotron for high-current applications
NASA Astrophysics Data System (ADS)
Pogue, N.; Assadi, S.; Badgley, K.; Comeaux, J.; Kellams, J.; McInturff, A.; McIntyre, P.; Sattarov, A.
2013-04-01
A superconducting strong-focusing cyclotron (SFC) is being developed for high-current applications. It incorporates four innovations. Superconducting quarter-wave cavities are used to provide >20 MV/turn acceleration. The orbit separation is thereby opened so that bunch-bunch interactions between successive orbits are eliminated. Quadrapole focusing channels are incorporated within the sectors so that alternating-gradient strong-focusing transport is maintained throughout. Dipole windings on the inner and outer orbits provide enhanced control for injection and extraction of bunches. Finally each sector magnet is configured as a flux-coupled stack of independent apertures, so that any desired number of independent cyclotrons can be integrated within a common footprint. Preliminary simulations indicate that each SFC should be capable of accelerating 10 mA CW to 800 MeV with very low loss and >50% energy efficiency. A primary motivation for SFC is as a proton driver for accelerator-driven subcritical fission in a molten salt core. The cores are fueled solely with the transuranics from spent nuclear fuel from a conventional nuclear power plant. The beams from one SFC stack would destroy all of the transuranics and long-lived fission products that are produced by a GWe reactor [1]. This capability offers the opportunity to close the nuclear fuel cycle and provide a path to green nuclear energy.
BIOCONAID System (Bionic Control of Acceleration Induced Dimming). Final Report.
ERIC Educational Resources Information Center
Rogers, Dana B.; And Others
The system described represents a new technique for enhancing the fidelity of flight simulators during high acceleration maneuvers. This technique forces the simulator pilot into active participation and energy expenditure similar to the aircraft pilot undergoing actual accelerations. The Bionic Control of Acceleration Induced Dimming (BIOCONAID)…
Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong
2016-11-22
Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new "transgene clean" TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable "transgene clean" TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new "transgene clean" TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis.
Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery
Isherwood, Beverley; Timpson, Paul; McGhee, Ewan J; Anderson, Kurt I; Canel, Marta; Serrels, Alan; Brunton, Valerie G; Carragher, Neil O
2011-01-01
Dynamic regulation of specific molecular processes and cellular phenotypes in live cell systems reveal unique insights into cell fate and drug pharmacology that are not gained from traditional fixed endpoint assays. Recent advances in microscopic imaging platform technology combined with the development of novel optical biosensors and sophisticated image analysis solutions have increased the scope of live cell imaging applications in drug discovery. We highlight recent literature examples where live cell imaging has uncovered novel insight into biological mechanism or drug mode-of-action. We survey distinct types of optical biosensors and associated analytical methods for monitoring molecular dynamics, in vitro and in vivo. We describe the recent expansion of live cell imaging into automated target validation and drug screening activities through the development of dedicated brightfield and fluorescence kinetic imaging platforms. We provide specific examples of how temporal profiling of phenotypic response signatures using such kinetic imaging platforms can increase the value of in vitro high-content screening. Finally, we offer a prospective view of how further application and development of live cell imaging technology and reagents can accelerate preclinical lead optimization cycles and enhance the in vitro to in vivo translation of drug candidates. PMID:24310493
Zhao, Hao; Feng, Hao
2013-01-01
An angular acceleration sensor can be used for the dynamic analysis of human and joint motions. In this paper, an angular acceleration sensor with novel structure based on the principle of electromagnetic induction is designed. The method involves the construction of a constant magnetic field by the excitation windings of sensor, and the cup-shaped rotor that cut the magnetic field. The output windings of the sensor generate an electromotive force, which is directly proportional to the angular acceleration through the electromagnetic coupling when the rotor has rotational angular acceleration. The mechanical structure and the magnetic working circuit of the sensor are described. The output properties and the mathematical model including the transfer function and state-space model of the sensor are established. The asymptotical stability of the sensor when it is working is verified by the Lyapunov Theorem. An angular acceleration calibration device based on the torsional pendulum principle is designed. The method involves the coaxial connection of the angular acceleration sensor, torsion pendulum and a high-precision angle sensor, and then an initial external force is applied to the torsion pendulum to produce a periodic damping angle oscillation. The angular acceleration sensor and the angle sensor will generate two corresponding electrical signals. The sensitivity coefficient of the angular acceleration sensor can be obtained after processing these two-channel signals. The experiment results show that the sensitivity coefficient of the sensor is about 17.29 mv/Krad·s2. Finally, the errors existing in the practical applications of the sensor are discussed and the corresponding improvement measures are proposed to provide effective technical support for the practical promotion of the novel sensor. PMID:23941911
Frequent Application of the New Gelatin-Collagen Nonwoven Accelerates Wound Healing.
Schiefer, Jennifer L; Rath, Rebekka; Held, Manuel; Petersen, Wiebke; Werner, Jan-Ole; Schaller, Hans-Eberhard; Rahmanian-Schwarz, Afshin
2016-02-01
Mortality after chronic wounds is high. Thus, proper and effective therapy is of critical importance. Adult mammalian skin cannot regenerate spontaneously. It heals under scar formation in a process of repair. In general, wound closure is achieved through a combination of contraction, scar formation, and regeneration. To enhance wound healing, research groups are continuously inventing and evaluating novel skin replacement products. A single application of a new gelatin-collagen nonwoven accelerates wound closure of full-thickness skin defects. Therefore, the authors' objective was to evaluate the effect of a higher application frequency of the nonwoven on wound closure in a minipig model. Four full-thickness skin defects were created surgically on the dorsum of 12 Göttingen minipigs. Next, 3 wounds were treated randomly with a novel gelatin-collagen nonwoven in different thicknesses, while the fourth wound was left untreated and served as the control wound. Moreover, 6 minipigs achieved multiple applications of the wound dressing. During the experimental period of 21 days, a close-up photographic documentation was performed. Finally, the areas of the initial wounds were excised and examined histologically. More frequent application of the nonwoven achieved accelerated wound healing and better epidermis quality compared with a single application. Mean time until wound closure of all wounds treated with a multiple application of the nonwoven was 11.0 (± 1.2) days, compared with a single application of the nonwoven with 12.4 (± 1.26) days and control wounds with 13.5 (± 1.19) days. Furthermore, the epidermal thickness of all wounds treated with multiple applications of the nonwoven was increased by 10.67 μm (31.89 ± 8.86 μm, P = .0007) compared with a single application of the nonwoven and by 6.53 μm (27.75 ± 7.24 μm, P = .0435) compared with the control group. Multiple applications of the gelatin-collagen nonwoven may be an appropriate treatment for chronic wounds leading to a fast wound closure through a combination of contraction and re-epithelialization.
Overview of Accelerator Applications in Energy
NASA Astrophysics Data System (ADS)
Garnett, Robert W.; Sheffield, Richard L.
An overview of the application of accelerators and accelerator technology in energy is presented. Applications span a broad range of cost, size, and complexity and include large-scale systems requiring high-power or high-energy accelerators to drive subcritical reactors for energy production or waste transmutation, as well as small-scale industrial systems used to improve oil and gas exploration and production. The enabling accelerator technologies will also be reviewed and future directions discussed.
NASA Astrophysics Data System (ADS)
Sawant, M.; Christou, A.
2012-12-01
While use of LEDs in Fiber Optics and lighting applications is common, their use in medical diagnostic applications is not very extensive. Since the precise value of light intensity will be used to interpret patient results, understanding failure modes [1-4] is very important. We used the Failure Modes and Effects Criticality Analysis (FMECA) tool to identify the critical failure modes of the LEDs. FMECA involves identification of various failure modes, their effects on the system (LED optical output in this context), their frequency of occurrence, severity and the criticality of the failure modes. The competing failure modes/mechanisms were degradation of: active layer (where electron-hole recombination occurs to emit light), electrodes (provides electrical contact to the semiconductor chip), Indium Tin Oxide (ITO) surface layer (used to improve current spreading and light extraction), plastic encapsulation (protective polymer layer) and packaging failures (bond wires, heat sink separation). A FMECA table is constructed and the criticality is calculated by estimating the failure effect probability (β), failure mode ratio (α), failure rate (λ) and the operating time. Once the critical failure modes were identified, the next steps were generation of prior time to failure distribution and comparing with our accelerated life test data. To generate the prior distributions, data and results from previous investigations were utilized [5-33] where reliability test results of similar LEDs were reported. From the graphs or tabular data, we extracted the time required for the optical power output to reach 80% of its initial value. This is our failure criterion for the medical diagnostic application. Analysis of published data for different LED materials (AlGaInP, GaN, AlGaAs), the Semiconductor Structures (DH, MQW) and the mode of testing (DC, Pulsed) was carried out. The data was categorized according to the materials system and LED structure such as AlGaInP-DH-DC, AlGaInP-MQW-DC, GaN-DH-DC, and GaN-DH-DC. Although the reported testing was carried out at different temperature and current, the reported data was converted to the present application conditions of the medical environment. Comparisons between the model data and accelerated test results carried out in the present are reported. The use of accelerating agent modeling and regression analysis was also carried out. We have used the Inverse Power Law model with the current density J as the accelerating agent and the Arrhenius model with temperature as the accelerating agent. Finally, our reported methodology is presented as an approach for analyzing LED suitability for the target medical diagnostic applications.
An Endogenous Accelerator for Viral Gene Expression Confers a Fitness Advantage
Teng, Melissa W.; Bolovan-Fritts, Cynthia; Dar, Roy D.; Womack, Andrew; Simpson, Michael L.; Shenk, Thomas; Weinberger, Leor S.
2012-01-01
Many signaling circuits face a fundamental tradeoff between accelerating their response speed while maintaining final levels below a cytotoxic threshold. Here, we describe a transcriptional circuitry that dynamically converts signaling inputs into faster rates without amplifying final equilibrium levels. Using time-lapse microscopy, we find that transcriptional activators accelerate human cytomegalovirus (CMV) gene expression in single cells without amplifying steady-state expression levels, and this acceleration generates a significant replication advantage. We map the accelerator to a highly self-cooperative transcriptional negative-feedback loop (Hill coefficient ~ 7) generated by homo-multimerization of the virus’s essential transactivator protein IE2 at nuclear PML bodies. Eliminating the IE2-accelerator circuit reduces transcriptional strength through mislocalization of incoming viral genomes away from PML bodies and carries a heavy fitness cost. In general, accelerators may provide a mechanism for signal-transduction circuits to respond quickly to external signals without increasing steady-state levels of potentially cytotoxic molecules. PMID:23260143
Advanced Accelerators for Medical Applications
NASA Astrophysics Data System (ADS)
Uesaka, Mitsuru; Koyama, Kazuyoshi
We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter “linac”); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laser-based acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.
Advanced Accelerators for Medical Applications
NASA Astrophysics Data System (ADS)
Uesaka, Mitsuru; Koyama, Kazuyoshi
We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter "linac"); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laserbased acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.
BBU design of linear induction accelerator cells for radiography application
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shang, C.C.; Chen, Y.J.; Gaporaso, G.J.
1997-05-06
There is an ongoing effort to develop accelerating modules for high-current electron accelerators for advanced radiography application. Accelerating modules with low beam-cavity coupling impedances along with gap designs with acceptable field stresses comprise a set of fundamental design criteria. We examine improved cell designs which have been developed for accelerator application in several radiographic operating regimes. We evaluate interaction impedances, analyze the effects of beam structure coupling on beam dynamics (beam break-up instability and corkscrew motion). We also provide estimates of coupling through interesting new high-gradient insulators and evaluate their potential future application in induction cells.
NASA Astrophysics Data System (ADS)
Dubinov, Alexander E.; Ochkina, Elena I.
2018-05-01
State-of-the-art compact recirculating electron accelerators operating at intermediate energies (tens of MeV) are reviewed. The acceleration schemes implemented in the rhodotron, ridgetron, fantron, and cylindertron machines are discussed. Major accelerator components such as the electron guns, accelerating cavities, and bending magnets are described. The parameters of currently operating recirculating accelerators are tabulated, and applications of these accelerators in different processes of irradiation are exemplified.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-19
...This document contains final regulations that provide guidance on the application of sections 162(a) and 263(a) of the Internal Revenue Code (Code) to amounts paid to acquire, produce, or improve tangible property. The final regulations clarify and expand the standards in the current regulations under sections 162(a) and 263(a). These final regulations replace and remove temporary regulations under sections 162(a) and 263(a) and withdraw proposed regulations that cross referenced the text of those temporary regulations. This document also contains final regulations under section 167 regarding accounting for and retirement of depreciable property and final regulations under section 168 regarding accounting for property under the Modified Accelerated Cost Recovery System (MACRS) other than general asset accounts. The final regulations will affect all taxpayers that acquire, produce, or improve tangible property. These final regulations do not finalize or remove the 2011 temporary regulations under section 168 regarding general asset accounts and disposition of property subject to section 168, which are addressed in the notice of proposed rulemaking on this subject in the Proposed Rules section in this issue of the Federal Register.
Pulsed electron accelerator for radiation technologies in the enviromental applications
NASA Astrophysics Data System (ADS)
Korenev, Sergey
1997-05-01
The project of pulsed electron accelerator for radiation technologies in the environmental applications is considered. An accelerator consists of high voltage generator with vacuum insulation and vacuum diode with plasma cathode on the basis discharge on the surface of dielectric of large dimensions. The main parameters of electron accelerators are following: kinetic energy 0.2 - 2.0 MeV, electron beam current 1 - 30 kA and pulse duration 1- 5 microseconds. The main applications of accelerator for decomposition of wastewaters are considered.
DOT National Transportation Integrated Search
2014-11-15
The simplified procedure in design codes for determining earthquake response spectra involves : estimating site coefficients to adjust available rock accelerations to site accelerations. Several : investigators have noted concerns with the site coeff...
Trends for Electron Beam Accelerator Applications in Industry
NASA Astrophysics Data System (ADS)
Machi, Sueo
2011-02-01
Electron beam (EB) accelerators are major pieces of industrial equipment used for many commercial radiation processing applications. The industrial use of EB accelerators has a history of more than 50 years and is still growing in terms of both its economic scale and new applications. Major applications involve the modification of polymeric materials to create value-added products, such as heat-resistant wires, heat-shrinkable sheets, automobile tires, foamed plastics, battery separators and hydrogel wound dressing. The surface curing of coatings and printing inks is a growing application for low energy electron accelerators, resulting in an environmentally friendly and an energy-saving process. Recently there has been the acceptance of the use of EB accelerators in lieu of the radioactive isotope cobalt-60 as a source for sterilizing disposable medical products. Environmental protection by the use of EB accelerators is a new and important field of application. A commercial plant for the cleaning flue gases from a coal-burning power plant is in operation in Poland, employing high power EB accelerators. In Korea, a commercial plant uses EB to clean waste water from a dye factory.
Evaluation of proton cross-sections for radiation sources in the proton accelerator
NASA Astrophysics Data System (ADS)
Cho, Young-Sik; Lee, Cheol-Woo; Lee, Young-Ouk
2007-08-01
Proton Engineering Frontier Project (PEFP) is currently building a proton accelerator in Korea which consists of a proton linear accelerator with 100 MeV of energy, 20 mA of current and various particle beam facilities. The final goal of this project consists of the production of 1 GeV proton beams, which will be used for various medical and industrial applications as well as for research in basic and applied sciences. Carbon and copper in the proton accelerator for PEPP, through activation, become radionuclides such as 7Be and 64Cu. Copper is a major element of the accelerator components and the carbon is planned to be used as a target material of the beam dump. A recent survey showed that the currently available cross-sections create a large difference from the experimental data in the production of some residual nuclides by the proton-induced reactions for carbon and copper. To more accurately estimate the production of radioactive nuclides in the accelerator, proton cross-sections for carbon and copper are evaluated. The TALYS code was used for the evaluation of the cross-sections for the proton-induced reactions. To obtain the cross-sections which best fits the experimental data, optical model parameters for the neutron, proton and other complex particles such as the deuteron and alpha were successively adjusted. The evaluated cross-sections in this study are compared with the measurements and other evaluations .
Feasibility study of a cyclotron complex for hadron therapy
NASA Astrophysics Data System (ADS)
Smirnov, V.; Vorozhtsov, S.
2018-04-01
An accelerator complex for hadron therapy based on a chain of cyclotrons is under development at JINR (Dubna, Russia), and the corresponding conceptual design is under preparation. The complex mainly consists of two superconducting cyclotrons. The first accelerator is a compact cyclotron used as an injector to the main accelerator, which is a six-fold separated sector machine. The facility is intended for generation of protons and carbon beams. The H2+ and 12C6+ ions from the corresponding ECR ion sources are accelerated in the injector-cyclotron up to the output energy of 70 MeV/u. Then, the H2+ ions are extracted from the injector by a stripping foil, and the resulting proton beam with the energy of 70 MeV is used for medical purposes. After acceleration in the main cyclotron, the carbon beam can be either used directly for therapy or introduced to the main cyclotron for obtaining the final energy of 400 MeV/u. The basic requirements to the project are the following: compliance to medical requirements, compact size, feasible design, and high reliability of all systems of the complex. The advantages of the dual cyclotron design can help reaching these goals. The initial calculations show that this design is technically feasible with acceptable beam dynamics. The accelerator complex with a relatively compact size can be a good solution for medical applications. The basic parameters of the facility and detailed investigation of the magnetic system and beam dynamics are described.
Novel particle and radiation sources and advanced materials
NASA Astrophysics Data System (ADS)
Mako, Frederick
2016-03-01
The influence Norman Rostoker had on the lives of those who had the pleasure of knowing him is profound. The skills and knowledge I gained as a graduate student researching collective ion acceleration has fueled a career that has evolved from particle beam physics to include particle and radiation source development and advanced materials research, among many other exciting projects. The graduate research performed on collective ion acceleration was extended by others to form the backbone for laser driven plasma ion acceleration. Several years after graduate school I formed FM Technologies, Inc., (FMT), and later Electron Technologies, Inc. (ETI). Currently, as the founder and president of both FMT and ETI, the Rostoker influence can still be felt. One technology that we developed is a self-bunching RF fed electron gun, called the Micro-Pulse Gun (MPG). The MPG has important applications for RF accelerators and microwave tube technology, specifically clinically improved medical linacs and "green" klystrons. In addition to electron beam and RF source research, knowledge of materials and material interactions gained indirectly in graduate school has blossomed into breakthroughs in materials joining technologies. Most recently, silicon carbide joining technology has been developed that gives robust helium leak tight, high temperature and high strength joints between ceramic-to-ceramic and ceramic-to-metal. This joining technology has the potential to revolutionize the ethylene production, nuclear fuel and solar receiver industries by finally allowing for the practical use of silicon carbide as furnace coils, fuel rods and solar receptors, respectively, which are applications that have been needed for decades.
Novel particle and radiation sources and advanced materials
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mako, Frederick
The influence Norman Rostoker had on the lives of those who had the pleasure of knowing him is profound. The skills and knowledge I gained as a graduate student researching collective ion acceleration has fueled a career that has evolved from particle beam physics to include particle and radiation source development and advanced materials research, among many other exciting projects. The graduate research performed on collective ion acceleration was extended by others to form the backbone for laser driven plasma ion acceleration. Several years after graduate school I formed FM Technologies, Inc., (FMT), and later Electron Technologies, Inc. (ETI). Currently,more » as the founder and president of both FMT and ETI, the Rostoker influence can still be felt. One technology that we developed is a self-bunching RF fed electron gun, called the Micro-Pulse Gun (MPG). The MPG has important applications for RF accelerators and microwave tube technology, specifically clinically improved medical linacs and “green” klystrons. In addition to electron beam and RF source research, knowledge of materials and material interactions gained indirectly in graduate school has blossomed into breakthroughs in materials joining technologies. Most recently, silicon carbide joining technology has been developed that gives robust helium leak tight, high temperature and high strength joints between ceramic-to-ceramic and ceramic-to-metal. This joining technology has the potential to revolutionize the ethylene production, nuclear fuel and solar receiver industries by finally allowing for the practical use of silicon carbide as furnace coils, fuel rods and solar receptors, respectively, which are applications that have been needed for decades.« less
Novel Uses of Video to Accelerate the Surgical Learning Curve.
Ibrahim, Andrew M; Varban, Oliver A; Dimick, Justin B
2016-04-01
Surgeons are under enormous pressure to continually improve and learn new surgical skills. Novel uses of surgical video in the preoperative, intraoperative, and postoperative setting are emerging to accelerate the learning curve of surgical skill and minimize harm to patients. In the preoperative setting, social media outlets provide a valuable platform for surgeons to collaborate and plan for difficult operative cases. Live streaming of video has allowed for intraoperative telementoring. Finally, postoperative use of video has provided structure for peer coaching to evaluate and improve surgical skill. Applying these approaches into practice is becoming easier as most of our surgical platforms (e.g., laparoscopic, and endoscopy) now have video recording technology built in and video editing software has become more user friendly. Future applications of video technology are being developed, including possible integration into accreditation and board certification.
The Advanced Composition Explorer Shock Database and Application to Particle Acceleration Theory
NASA Technical Reports Server (NTRS)
Parker, L. Neergaard; Zank, G. P.
2015-01-01
The theory of particle acceleration via diffusive shock acceleration (DSA) has been studied in depth by Gosling et al. (1981), van Nes et al. (1984), Mason (2000), Desai et al. (2003), Zank et al. (2006), among many others. Recently, Parker and Zank (2012, 2014) and Parker et al. (2014) using the Advanced Composition Explorer (ACE) shock database at 1 AU explored two questions: does the upstream distribution alone have enough particles to account for the accelerated downstream distribution and can the slope of the downstream accelerated spectrum be explained using DSA? As was shown in this research, diffusive shock acceleration can account for a large population of the shocks. However, Parker and Zank (2012, 2014) and Parker et al. (2014) used a subset of the larger ACE database. Recently, work has successfully been completed that allows for the entire ACE database to be considered in a larger statistical analysis. We explain DSA as it applies to single and multiple shocks and the shock criteria used in this statistical analysis. We calculate the expected injection energy via diffusive shock acceleration given upstream parameters defined from the ACE Solar Wind Electron, Proton, and Alpha Monitor (SWEPAM) data to construct the theoretical upstream distribution. We show the comparison of shock strength derived from diffusive shock acceleration theory to observations in the 50 keV to 5 MeV range from an instrument on ACE. Parameters such as shock velocity, shock obliquity, particle number, and time between shocks are considered. This study is further divided into single and multiple shock categories, with an additional emphasis on forward-forward multiple shock pairs. Finally with regard to forward-forward shock pairs, results comparing injection energies of the first shock, second shock, and second shock with previous energetic population will be given.
The Advanced Composition Explorer Shock Database and Application to Particle Acceleration Theory
NASA Technical Reports Server (NTRS)
Parker, L. Neergaard; Zank, G. P.
2015-01-01
The theory of particle acceleration via diffusive shock acceleration (DSA) has been studied in depth by Gosling et al. (1981), van Nes et al. (1984), Mason (2000), Desai et al. (2003), Zank et al. (2006), among many others. Recently, Parker and Zank (2012, 2014) and Parker et al. (2014) using the Advanced Composition Explorer (ACE) shock database at 1 AU explored two questions: does the upstream distribution alone have enough particles to account for the accelerated downstream distribution and can the slope of the downstream accelerated spectrum be explained using DSA? As was shown in this research, diffusive shock acceleration can account for a large population of the shocks. However, Parker and Zank (2012, 2014) and Parker et al. (2014) used a subset of the larger ACE database. Recently, work has successfully been completed that allows for the entire ACE database to be considered in a larger statistical analysis. We explain DSA as it applies to single and multiple shocks and the shock criteria used in this statistical analysis. We calculate the expected injection energy via diffusive shock acceleration given upstream parameters defined from the ACE Solar Wind Electron, Proton, and Alpha Monitor (SWEPAM) data to construct the theoretical upstream distribution. We show the comparison of shock strength derived from diffusive shock acceleration theory to observations in the 50 keV to 5 MeV range from an instrument on ACE. Parameters such as shock velocity, shock obliquity, particle number, and time between shocks are considered. This study is further divided into single and multiple shock categories, with an additional emphasis on forward-forward multiple shock pairs. Finally with regard to forwardforward shock pairs, results comparing injection energies of the first shock, second shock, and second shock with previous energetic population will be given.
Robson, Philip M; Grant, Aaron K; Madhuranthakam, Ananth J; Lattanzi, Riccardo; Sodickson, Daniel K; McKenzie, Charles A
2008-10-01
Parallel imaging reconstructions result in spatially varying noise amplification characterized by the g-factor, precluding conventional measurements of noise from the final image. A simple Monte Carlo based method is proposed for all linear image reconstruction algorithms, which allows measurement of signal-to-noise ratio and g-factor and is demonstrated for SENSE and GRAPPA reconstructions for accelerated acquisitions that have not previously been amenable to such assessment. Only a simple "prescan" measurement of noise amplitude and correlation in the phased-array receiver, and a single accelerated image acquisition are required, allowing robust assessment of signal-to-noise ratio and g-factor. The "pseudo multiple replica" method has been rigorously validated in phantoms and in vivo, showing excellent agreement with true multiple replica and analytical methods. This method is universally applicable to the parallel imaging reconstruction techniques used in clinical applications and will allow pixel-by-pixel image noise measurements for all parallel imaging strategies, allowing quantitative comparison between arbitrary k-space trajectories, image reconstruction, or noise conditioning techniques. (c) 2008 Wiley-Liss, Inc.
Microstructural changes in a cementitious membrane due to the application of a DC electric field.
Covelo, Alba; Diaz, Belen; Freire, Lorena; Novoa, X Ramon; Perez, M Consuelo
2008-07-01
The use of electromigration techniques to accelerate chloride ions motion is commonly employed to characterise the permeability of cementitious samples to chlorides, a relevant parameter in reinforced concrete corrosion. This paper is devoted to the study of microstructure's changes occurring in mortar samples when submitted to natural diffusion and migration experiments. The application of an electric field reduces testing time in about one order of magnitude with respect to natural diffusion experiments. Nevertheless, the final sample's microstructure differs in both tests. Impedance Spectroscopy is employed for real time monitoring of microstructural changes. During migration experiments the global impedance undergoes important increase in shorter period of time compared to natural diffusion tests. So, the forced motion of ions through the concrete membrane induces significant variations in the porous structure, as confirmed by Mercury Intrusion Porosimetry. After migration experiments, an important increase in the capillary pore size (10-100 nm) was detected. Conversely, no relevant variations are found after natural diffusion tests. Results presented in this work cast doubt on the significance of diffusion coefficient values obtained under accelerated conditions.
Convergence acceleration of the Proteus computer code with multigrid methods
NASA Technical Reports Server (NTRS)
Demuren, A. O.; Ibraheem, S. O.
1995-01-01
This report presents the results of a study to implement convergence acceleration techniques based on the multigrid concept in the two-dimensional and three-dimensional versions of the Proteus computer code. The first section presents a review of the relevant literature on the implementation of the multigrid methods in computer codes for compressible flow analysis. The next two sections present detailed stability analysis of numerical schemes for solving the Euler and Navier-Stokes equations, based on conventional von Neumann analysis and the bi-grid analysis, respectively. The next section presents details of the computational method used in the Proteus computer code. Finally, the multigrid implementation and applications to several two-dimensional and three-dimensional test problems are presented. The results of the present study show that the multigrid method always leads to a reduction in the number of iterations (or time steps) required for convergence. However, there is an overhead associated with the use of multigrid acceleration. The overhead is higher in 2-D problems than in 3-D problems, thus overall multigrid savings in CPU time are in general better in the latter. Savings of about 40-50 percent are typical in 3-D problems, but they are about 20-30 percent in large 2-D problems. The present multigrid method is applicable to steady-state problems and is therefore ineffective in problems with inherently unstable solutions.
The equations of motion for moist atmospheric air
NASA Astrophysics Data System (ADS)
Makarieva, Anastassia M.; Gorshkov, Victor G.; Nefiodov, Andrei V.; Sheil, Douglas; Nobre, Antonio Donato; Bunyard, Peter; Nobre, Paulo; Li, Bai-Lian
2017-07-01
How phase transitions affect the motion of moist atmospheric air remains controversial. In the early 2000s two distinct differential equations of motion were proposed. Besides their contrasting formulations for the acceleration of condensate, the equations differ concerning the presence/absence of a term equal to the rate of phase transitions multiplied by the difference in velocity between condensate and air. This term was interpreted in the literature as the "reactive motion" associated with condensation. The reasoning behind this reactive motion was that when water vapor condenses and droplets begin to fall the remaining gas must move upward to conserve momentum. Here we show that the two contrasting formulations imply distinct assumptions about how gaseous air and condensate particles interact. We show that these assumptions cannot be simultaneously applicable to condensation and evaporation. Reactive motion leading to an upward acceleration of air during condensation does not exist. The reactive motion term can be justified for evaporation only; it describes the downward acceleration of air. We emphasize the difference between the equations of motion (i.e., equations constraining velocity) and those constraining momentum (i.e., equations of motion and continuity combined). We show that owing to the imprecise nature of the continuity equations, consideration of total momentum can be misleading and that this led to the reactive motion controversy. Finally, we provide a revised and generally applicable equation for the motion of moist air.
NASA Astrophysics Data System (ADS)
Fonseca, R. A.; Vieira, J.; Fiuza, F.; Davidson, A.; Tsung, F. S.; Mori, W. B.; Silva, L. O.
2013-12-01
A new generation of laser wakefield accelerators (LWFA), supported by the extreme accelerating fields generated in the interaction of PW-Class lasers and underdense targets, promises the production of high quality electron beams in short distances for multiple applications. Achieving this goal will rely heavily on numerical modelling to further understand the underlying physics and identify optimal regimes, but large scale modelling of these scenarios is computationally heavy and requires the efficient use of state-of-the-art petascale supercomputing systems. We discuss the main difficulties involved in running these simulations and the new developments implemented in the OSIRIS framework to address these issues, ranging from multi-dimensional dynamic load balancing and hybrid distributed/shared memory parallelism to the vectorization of the PIC algorithm. We present the results of the OASCR Joule Metric program on the issue of large scale modelling of LWFA, demonstrating speedups of over 1 order of magnitude on the same hardware. Finally, scalability to over ˜106 cores and sustained performance over ˜2 P Flops is demonstrated, opening the way for large scale modelling of LWFA scenarios.
Convergence acceleration of molecular dynamics methods for shocked materials using velocity scaling
NASA Astrophysics Data System (ADS)
Taylor, DeCarlos E.
2017-03-01
In this work, a convergence acceleration method applicable to extended system molecular dynamics techniques for shock simulations of materials is presented. The method uses velocity scaling to reduce the instantaneous value of the Rankine-Hugoniot conservation of energy constraint used in extended system molecular dynamics methods to more rapidly drive the system towards a converged Hugoniot state. When used in conjunction with the constant stress Hugoniostat method, the velocity scaled trajectories show faster convergence to the final Hugoniot state with little difference observed in the converged Hugoniot energy, pressure, volume and temperature. A derivation of the scale factor is presented and the performance of the technique is demonstrated using the boron carbide armour ceramic as a test material. It is shown that simulation of boron carbide Hugoniot states, from 5 to 20 GPa, using both a classical Tersoff potential and an ab initio density functional, are more rapidly convergent when the velocity scaling algorithm is applied. The accelerated convergence afforded by the current algorithm enables more rapid determination of Hugoniot states thus reducing the computational demand of such studies when using expensive ab initio or classical potentials.
New applications of particle accelerators in medicine, materials science, and industry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Knapp, E.A.
1981-01-01
Recently, the application of particle accelerators to medicine, materials science, and other industrial uses has increased dramatically. A random sampling of some of these new programs is discussed, primarily to give the scope of these new applications. The three areas, medicine, materials science or solid-state physics, and industrial applications, are chosen for their diversity and are representative of new accelerator applications for the future.
A pixel detector system for laser-accelerated ion detection
NASA Astrophysics Data System (ADS)
Reinhardt, S.; Draxinger, W.; Schreiber, J.; Assmann, W.
2013-03-01
Laser ion acceleration is an unique acceleration process that creates ultra-short ion pulses of high intensity ( > 107 ions/cm2/ns), which makes online detection an ambitious task. Non-electronic detectors such as radio-chromic films (RCF), imaging plates (IP) or nuclear track detectors (e.g. CR39) are broadly used at present. Only offline information on ion pulse intensity and position are available by these detectors, as minutes to hours of processing time are required after their exposure. With increasing pulse repetition rate of the laser system, there is a growing need for detection of laser accelerated ions in real-time. Therefore, we have investigated a commercial pixel detector system for online detection of laser-accelerated proton pulses. The CMOS imager RadEye1 was chosen, which is based on a photodiode array, 512 × 1024 pixels with 48 μm pixel pitch, thus offering a large sensitive area of approximately 25 × 50 mm2. First detection tests were accomplished at the conventional electrostatic 14 MV Tandem accelerator in Munich as well as Atlas laser accelerator. Detector response measurements at the conventional accelerator have been accomplished in a proton beam in dc (15 MeV) and pulsed (20 MeV) irradiation mode, the latter providing comparable particle flux as under laser acceleration conditions. Radiation hardness of the device was studied using protons (20 MeV) and C-ions (77 MeV), additionally. The detector system shows a linear response up to a maximum pulse flux of about 107 protons/cm2/ns. Single particle detection is possible in a low flux beam (104 protons/cm2/s) for all investigated energies. The radiation hardness has shown to give reasonable lifetime for an application at the laser accelerator. The results from the irradiation at a conventional accelerator are confirmed by a cross-calibration with CR39 in a laser-accelerated proton beam at the MPQ Atlas Laser in Garching, showing no problems of detector operation in presence of electro-magnetic pulse (EMP). The calibrated detector system was finally used for online detection of laser-accelerated proton and carbon ions at the Astra-Gemini laser.
Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong
2016-01-01
Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new “transgene clean” TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable “transgene clean” TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new “transgene clean” TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis. PMID:27874087
Ultra-High Accelerating Gradients in Radio-Frequency Cryogenic Copper Structures
NASA Astrophysics Data System (ADS)
Cahill, Alexander David
Normal conducting radio-frequency (rf) particle accelerators have many applications, including colliders for high energy physics, high-intensity synchrotron light sources, non-destructive testing for security, and medical radiation therapy. In these applications, the accelerating gradient is an important parameter. Specifically for high energy physics, increasing the accelerating gradient extends the potential energy reach and is viewed as a way to mitigate their considerable cost. Furthermore, a gradient increase will enable for more compact and thus accessible free electron lasers (FELs). The major factor limiting larger accelerating gradients is vacuum rf breakdown. Basic physics of this phenomenon has been extensively studied over the last few decades. During which, the occurrence of rf breakdowns was shown to be probabilistic, and can be characterized by a breakdown rate. The current consensus is that vacuum rf breakdowns are caused by movements of crystal defects induced by periodic mechanical stress. The stress may be caused by pulsed surface heating and large electric fields. A compelling piece of evidence that supports this hypothesis is that accelerating structures constructed from harder materials exhibit larger accelerating gradients for similar breakdown rates. One possible method to increase sustained electric fields in copper cavities is to cool them to temperatures below 77 K, where the rf surface resistance and coefficient of thermal expansion decrease, while the yield strength (which correlates with hardness) and thermal conductivity increase. These changes in material properties at low temperature increases metal hardness and decreases the mechanical stress from exposure to rf electromagnetic fields. To test the validity of the improvement in breakdown rate, experiments were conducted with cryogenic accelerating cavities in the Accelerator Structure Test Area (ASTA) at SLAC National Accelerator Laboratory. A short 11.4 GHz standing wave accelerating structure was conditioned to an accelerating gradient of 250 MV/m at 45 K with 108 rf pulses. At gradients greater than 150 MV/m I observed a degradation in the intrinsic quality factor of the cavity, Q0. I developed a model for the change in Q0 using measured field emission currents and rf signals. I found that the Q 0 degradation is consistent with the rf power being absorbed by strong field emission currents accelerated inside the cavity. I measured rf breakdown rates for 45 K and found 2*10-4/pulse/meter when accounting for any change in Q0. These are the largest accelerating gradients for a structure with similar breakdown rates. The final chapter presents the design of an rf photoinjector electron source that uses the cryogenic normal conducting accelerator technology: the TOPGUN. With this cryogenic rf photoinjector, the beam brightness will increase by over an order of a magnitude when compared to the current photoinjector for the Linac Coherent Light Source (LCLS). When using the TOPGUN as the source for an X-ray Free Electron Laser, the higher brightness would allow for a decrease in the required length of the LCLS undulator by more than a factor of two.
NASA Astrophysics Data System (ADS)
Strathdee, A.
1985-10-01
The topics discussed are related to high-energy accelerators and colliders, particle sources and electrostatic accelerators, controls, instrumentation and feedback, beam dynamics, low- and intermediate-energy circular accelerators and rings, RF and other acceleration systems, beam injection, extraction and transport, operations and safety, linear accelerators, applications of accelerators, radiation sources, superconducting supercolliders, new acceleration techniques, superconducting components, cryogenics, and vacuum. Accelerator and storage ring control systems are considered along with linear and nonlinear orbit theory, transverse and longitudinal instabilities and cures, beam cooling, injection and extraction orbit theory, high current dynamics, general beam dynamics, and medical and radioisotope applications. Attention is given to superconducting RF structures, magnet technology, superconducting magnets, and physics opportunities with relativistic heavy ion accelerators.
Exploring the Impacts of Accelerated Delivery on Student Learning, Achievement and Satisfaction
ERIC Educational Resources Information Center
Wilkins, Stephen; Martin, Susan; Walker, Ian
2010-01-01
This case study examines the impacts on student learning, achievement and satisfaction when year 13 (final year) students at a large UK sixth-form college take a GCE A level in one year instead of the usual two years. Data relating to the entry qualifications and final A level grades achieved by 879 students on both accelerated and non-accelerated…
NASA Astrophysics Data System (ADS)
Nocente, M.; Tardocchi, M.; Olariu, A.; Olariu, S.; Pereira, R. C.; Chugunov, I. N.; Fernandes, A.; Gin, D. B.; Grosso, G.; Kiptily, V. G.; Neto, A.; Shevelev, A. E.; Silva, M.; Sousa, J.; Gorini, G.
2013-04-01
High resolution γ-ray spectroscopy measurements at MHz counting rates were carried out at nuclear accelerators, combining a LaBr 3(Ce) detector with dedicated hardware and software solutions based on digitization and off-line analysis. Spectra were measured at counting rates up to 4 MHz, with little or no degradation of the energy resolution, adopting a pile up rejection algorithm. The reported results represent a step forward towards the final goal of high resolution γ-ray spectroscopy measurements on a burning plasma device.
DOE Office of Scientific and Technical Information (OSTI.GOV)
De Supinski, B.; Caliga, D.
2017-09-28
The primary objective of this project was to develop memory optimization technology to efficiently deliver data to, and distribute data within, the SRC-6's Field Programmable Gate Array- ("FPGA") based Multi-Adaptive Processors (MAPs). The hardware/software approach was to explore efficient MAP configurations and generate the compiler technology to exploit those configurations. This memory accessing technology represents an important step towards making reconfigurable symmetric multi-processor (SMP) architectures that will be a costeffective solution for large-scale scientific computing.
Improved motors for utility applications: Volume 6, Squirrel-cage rotor analysis: Final report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Griffith, J.W.; McCoy, R.M.
1986-11-01
An analysis of squirrel cage induction motor rotors was undertaken in response to an Industry Assessment Study finding 10% of motor failures to be rotor related. The analysis focuses on evaluating rotor design life. The evaluation combines state-of-the-art electromagnetic, thermal, and structural solution techniques into an integrated analysis and presents a simple summary. Finite element techniques are central tools in the analysis. The analysis is applied to a specific forced draft fan drive design. Fans as a category of application have a higher failure rate than other categories of power station auxiliary motor applications. Forced-draft fan drives are one ofmore » the major fan drives which accelerate a relatively high value of rotor load inertia. Various starting and operating conditions are studied for this forced-draft fan drive motor including a representative application duty cycle.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Spentzouris, P.; /Fermilab; Cary, J.
The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessarymore » accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The ComPASS organization for software development and applications accounts for the natural domain areas (beam dynamics, electromagnetics, and advanced acceleration), and all areas depend on the enabling technologies activities, such as solvers and component technology, to deliver the desired performance and integrated simulation environment. The ComPASS applications focus on computationally challenging problems important for design or performance optimization to all major HEP, NP, and BES accelerator facilities. With the cost and complexity of particle accelerators rising, the use of computation to optimize their designs and find improved operating regimes becomes essential, potentially leading to significant cost savings with modest investment.« less
1998-02-01
provide the aircrew and passengers with a level of protection commensurate with the risk of operating aircraft in the military and civilian...the time taken to reach peak acceleration and upon the peak acceleration level attained. Long duration acceleration, which can be experienced in...acceleration depends principally on the plateau level of the acceleration imposed on the body, as the response to long duration acceleration is due
Accelerated Application Development: The ORNL Titan Experience
Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; ...
2015-05-09
The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less
Accelerated application development: The ORNL Titan experience
DOE Office of Scientific and Technical Information (OSTI.GOV)
Joubert, Wayne; Archibald, Rick; Berrill, Mark
2015-08-01
The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less
Dating Studies of Elephant Tusks Using Accelerator Mass Spectrometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sideras-Haddad, E; Brown, T A
A new method for determining the year of birth, the year of death, and hence, the age at death, of post-bomb and recently deceased elephants has been developed. The technique is based on Accelerator Mass Spectrometry radiocarbon analyses of small-sized samples extracted from along the length of a ge-line of an elephant tusk. The measured radiocarbon concentrations in the samples from a tusk can be compared to the {sup 14}C atmospheric bomb-pulse curve to derive the growth years of the initial and final samples from the tusk. Initial data from the application of this method to two tusks will bemore » presented. Potentially, the method may play a significant role in wildlife management practices of African national parks. Additionally, the method may contribute to the underpinnings of efforts to define new international trade regulations, which could, in effect, decrease poaching and the killing of very young animals.« less
High-Energy Neutron Imaging Development at LLNL
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hall, J M; Rusnak, B; Shen, S
2005-02-16
We are proceeding with the development of a high-energy (10 MeV) neutron imaging system for use as an inspection tool in nuclear stockpile stewardship applications. Our goal is to develop and deploy an imaging system capable of detecting cubic-mm-scale voids, cracks or other significant structural defects in heavily-shielded low-Z materials within nuclear device components. The final production-line system will be relatively compact (suitable for use in existing facilities within the DOE complex) and capable of acquiring both radiographic and tomographic (CT) images. In this report, we will review our recent programmatic accomplishments, focusing primarily on progress made in FY04. Themore » design status of the high-intensity, accelerator-driven neutron source and large-format imaging detector associated with the system will be discussed and results from a recent high-energy neutron imaging experiment conducted at the Ohio University Accelerator Laboratory (OUAL) will also be presented.« less
Electric rail gun projectile acceleration to high velocity
NASA Technical Reports Server (NTRS)
Bauer, D. P.; Mccormick, T. J.; Barber, J. P.
1982-01-01
Electric rail accelerators are being investigated for application in electric propulsion systems. Several electric propulsion applications require that the rail accelerator be capable of launching projectiles at velocities above 10 km/s. An experimental program was conducted to develop rail accelerator technology for high velocity projectile launch. Several 6 mm bore, 3 m long rail accelerators were fabricated. Projectiles with a mass of 0.2 g were accelerated by plasmas, carrying currents up to 150 kA. Experimental design and results are described. Results indicate that the accelerator performed as predicted for a fraction of the total projectile acceleration. The disparity between predicted and measured results are discussed.
Leung, Ka-Ngo; Gough, Richard A.; Ji, Qing; Lee, Yung-Hee Yvette
1999-01-01
A focused ion beam (FIB) system produces a final beam spot size down to 0.1 .mu.m or less and an ion beam output current on the order of microamps. The FIB system increases ion source brightness by properly configuring the first (plasma) and second (extraction) electrodes. The first electrode is configured to have a high aperture diameter to electrode thickness aspect ratio. Additional accelerator and focusing electrodes are used to produce the final beam. As few as five electrodes can be used, providing a very compact FIB system with a length down to only 20 mm. Multibeamlet arrangements with a single ion source can be produced to increase throughput. The FIB system can be used for nanolithography and doping applications for fabrication of semiconductor devices with minimum feature sizes of 0.1 .mu.m or less.
Leung, K.; Gough, R.A.; Ji, Q.; Lee, Y.Y.
1999-08-31
A focused ion beam (FIB) system produces a final beam spot size down to 0.1 {mu}m or less and an ion beam output current on the order of microamps. The FIB system increases ion source brightness by properly configuring the first (plasma) and second (extraction) electrodes. The first electrode is configured to have a high aperture diameter to electrode thickness aspect ratio. Additional accelerator and focusing electrodes are used to produce the final beam. As few as five electrodes can be used, providing a very compact FIB system with a length down to only 20 mm. Multibeamlet arrangements with a single ion source can be produced to increase throughput. The FIB system can be used for nanolithography and doping applications for fabrication of semiconductor devices with minimum feature sizes of 0.1 m or less. 13 figs.
NASA Astrophysics Data System (ADS)
Brownjohn, James Mark William; Bocian, Mateusz; Hester, David; Quattrone, Antonino; Hudson, William; Moore, Daniel; Goh, Sushma; Lim, Meng Sun
2016-12-01
With the main focus on safety, design of structures for vibration serviceability is often overlooked or mismanaged, resulting in some high profile structures failing publicly to perform adequately under human dynamic loading due to walking, running or jumping. A standard tool to inform better design, prove fitness for purpose before entering service and design retrofits is modal testing, a procedure that typically involves acceleration measurements using an array of wired sensors and force generation using a mechanical shaker. A critical but often overlooked aspect is using input (force) to output (response) relationships to enable estimation of modal mass, which is a key parameter directly controlling vibration levels in service. This paper describes the use of wireless inertial measurement units (IMUs), designed for biomechanics motion capture applications, for the modal testing of a 109 m footbridge. IMUs were first used for an output-only vibration survey to identify mode frequencies, shapes and damping ratios, then for simultaneous measurement of body accelerations of a human subject jumping to excite specific vibrations modes and build up bridge deck accelerations at the jumping location. Using the mode shapes and the vertical acceleration data from a suitable body landmark scaled by body mass, thus providing jumping force data, it was possible to create frequency response functions and estimate modal masses. The modal mass estimates for this bridge were checked against estimates obtained using an instrumented hammer and known mass distributions, showing consistency among the experimental estimates. Finally, the method was used in an applied research application on a short span footbridge where the benefits of logistical and operational simplicity afforded by the highly portable and easy to use IMUs proved extremely useful for an efficient evaluation of vibration serviceability, including estimation of modal masses.
Theory and measurements of emittance preservation in plasma wakefield acceleration
DOE Office of Scientific and Technical Information (OSTI.GOV)
Frederico, Joel
2016-12-01
In this dissertation, we examine the preservation and measurement of emittance in the plasma wakefield acceleration blowout regime. Plasma wakefield acceleration (PWFA) is a revolutionary approach to accelerating charged particles that has been demonstrated to have the potential for gradients orders of magnitude greater than traditional approaches. The application of PWFA to the design of a linear collider will make new high energy physics research possible, but the design parameters must first be shown to be competitive with traditional methods. Emittance preservation is necessary in the design of a linear collider in order to maximize luminosity. We examine the conditionsmore » necessary for circular symmetry in the PWFA blowout regime, and demonstrate that current proposals meet these bounds. We also present an application of beam lamentation which describes the process of beam parameter and emittance matching. We show that the emittance growth saturates as a consequence of energy spread in the beam. The initial beam parameters determine the amount of emittance growth, while the contribution of energy spread is negligible. We also present a model for ion motion in the presence of a beam that is much more dense than the plasma. By combining the model of ion motion and emittance growth, we find the emittance growth due to ion motion is minimal in the case of marginal ion motion. In addition, we present a simulation that validates the ion motion model, which is under further development to examine emittance growth of both marginal and pronounced ion motion. Finally, we present a proof-of-concept of an emittance measurement which may enable the analysis of emittance preservation in future PWFA experiments.« less
NASA Astrophysics Data System (ADS)
Van Lancker, Marc; Herer, Arnold; Cleland, Marshall R.; Jongen, Yves; Abs, Michel
1999-05-01
The Rhodotron is a high-voltage, high-power electron beam accelerator based on a design concept first proposed in 1989 by J. Pottier of the French Atomic Agency, Commissariat à l'Energie Atomique (CEA). In December 1991, the Belgian particle accelerator manufacturer, Ion Beam Applications s.a. (IBA) entered into an exclusive agreement with the CEA to develop and industrialize the Rhodotron. Electron beams have long been used as the preferential method to cross-link a variety of polymers, either in their bulk state or in their final form. Used extensively in the wire and cable industry to toughen insulating jackets, electron beam-treated plastics can demonstrate improved tensile and impact strength, greater abrasion resistance, increased temperature resistance and dramatically improved fire retardation. Electron beams are used to selectively cross-link or degrade a wide range of polymers in resin pellets form. Electron beams are also used for rapid curing of advanced composites, for cross-linking of floor-heating and sanitary pipes and for cross-linking of formed plastic parts. Other applications include: in-house and contract medical device sterilization, food irradiation in both electron and X-ray modes, pulp processing, electron beam doping of semi-conductors, gemstone coloration and general irradiation research. IBA currently markets three models of the Rhodotron, all capable of 10 MeV and alternate beam energies from 3 MeV upwards. The Rhodotron models TT100, TT200 and TT300 are typically specified with guaranteed beam powers of 35, 80 and 150 kW, respectively. Founded in 1986, IBA, a spin-off of the Cyclotron Research Center at the University of Louvain (UCL) in Belgium, is a pioneer in accelerator design for industrial-scale production.
All-magnetic extraction for cyclotron beam reacceleration
Hudson, E.D.; Mallory, M.L.
1975-07-22
An isochronous cyclotron can be modified to provide an initial electron stripping stage, a complete acceleration of the stripped ions through the cyclotron to a first energy state, means for returning the ions to an intermediate cyclotron orbit through a second stripping stage, further acceleration of the now higher energy stripped ions through the cyclotron to their final energy, and final extraction of the ions from the cyclotron. (auth)
Spheromaks and how plasmas may explain the ultra high energy cosmic ray mystery
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fowler, T. Kenneth; Li, Hui
In recent papers, we show how accretion disks around massive black holes could act as dynamos producing magnetic jets similar to the jets that create spheromaks in the laboratory. In this paper, we discuss how these magnetic astrophysical jets might naturally produce runaway ion beams accelerated tomore » $$10^{20}$$ eV or more, finally ejected as ultra high energy cosmic rays (UHECRs) long regarded as one of the mysteries of astrophysics. The acceleration is mainly due to the drift cyclotron loss cone kinetic instability known from plasma research. Finally, experiments and simulations are suggested to verify the acceleration process.« less
Dynamic control of ocular disaccommodation: First and second-order dynamics
Bharadwaj, Shrikant R.; Schor, Clifton M.
2006-01-01
Velocity and acceleration characteristics provide valuable information about dynamic control of accommodation. We investigated velocity and acceleration of disaccommodation (near-far focusing) from three starting positions. Peak velocity and peak acceleration of disaccommodation increased with the proximity of starting position however for a given starting position they were invariant of response magnitude. These results suggest that all disaccommodation responses are initiated towards a constant primary destination and are switched mid-flight to attain the desired final position. Large discrepancies between the primary destination and desired final position appear to produce overshoots and oscillations of small responses from proximal starting positions. PMID:16045960
Spheromaks and how plasmas may explain the ultra high energy cosmic ray mystery
Fowler, T. Kenneth; Li, Hui
2016-10-10
In recent papers, we show how accretion disks around massive black holes could act as dynamos producing magnetic jets similar to the jets that create spheromaks in the laboratory. In this paper, we discuss how these magnetic astrophysical jets might naturally produce runaway ion beams accelerated tomore » $$10^{20}$$ eV or more, finally ejected as ultra high energy cosmic rays (UHECRs) long regarded as one of the mysteries of astrophysics. The acceleration is mainly due to the drift cyclotron loss cone kinetic instability known from plasma research. Finally, experiments and simulations are suggested to verify the acceleration process.« less
Structural and functional photoacoustic molecular tomography aided by emerging contrast agents
Nie, Liming
2015-01-01
Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensive research has been focused on developing new contrast agents to improve the imaging sensitivity, specificity and efficiency. These emerging materials have substantially accelerated PAT applications in signal sensing, functional imaging, biomarker labeling and therapy monitoring etc. Here, the potentials of different optical probes as PAT contrast agents were elucidated. We first describe the instrumental embodiments and the measured functional parameters, then focus on emerging contrast agent-based PAT applications, and finally discuss the challenges and prospects. PMID:24967718
Applications of Brain–Machine Interface Systems in Stroke Recovery and Rehabilitation
Francisco, Gerard E.; Contreras-Vidal, Jose L.
2014-01-01
Stroke is a leading cause of disability, significantly impacting the quality of life (QOL) in survivors, and rehabilitation remains the mainstay of treatment in these patients. Recent engineering and technological advances such as brain-machine interfaces (BMI) and robotic rehabilitative devices are promising to enhance stroke neu-rorehabilitation, to accelerate functional recovery and improve QOL. This review discusses the recent applications of BMI and robotic-assisted rehabilitation in stroke patients. We present the framework for integrated BMI and robotic-assisted therapies, and discuss their potential therapeutic, assistive and diagnostic functions in stroke rehabilitation. Finally, we conclude with an outlook on the potential challenges and future directions of these neurotechnologies, and their impact on clinical rehabilitation. PMID:25110624
R&D status of linear collider technology at KEK
NASA Astrophysics Data System (ADS)
Urakawa, Junji
1992-02-01
This paper gives an outline of the Japan Linear Collider (JLC) project, especially JLC-I. The status of the various R&D works is particularly presented for the following topics: (1) electron and positron sources, (2) S-band injector linacs, (3) damping rings, (4) high power klystrons and accelerating structures, (5) the final focus system. Finally, the status of the construction and design studies for the Accelerator Test Facility (ATF) is summarized.
Frontier applications of electrostatic accelerators
NASA Astrophysics Data System (ADS)
Liu, Ke-Xin; Wang, Yu-Gang; Fan, Tie-Shuan; Zhang, Guo-Hui; Chen, Jia-Er
2013-10-01
Electrostatic accelerator is a powerful tool in many research fields, such as nuclear physics, radiation biology, material science, archaeology and earth sciences. Two electrostatic accelerators, one is the single stage Van de Graaff with terminal voltage of 4.5 MV and another one is the EN tandem with terminal voltage of 6 MV, were installed in 1980s and had been put into operation since the early 1990s at the Institute of Heavy Ion Physics. Many applications have been carried out since then. These two accelerators are described and summaries of the most important applications on neutron physics and technology, radiation biology and material science, as well as accelerator mass spectrometry (AMS) are presented.
Acceleration and focusing of plasma flows
DOE Office of Scientific and Technical Information (OSTI.GOV)
Griswold, Martin Elias
The acceleration of flowing plasmas is a fundamental problem that is useful in a wide variety of technological applications. We consider the problem from the perspective of plasma propulsion. Gridded ion thrusters and Hall thrusters are the most commonly used devices to create flowing plasma for space propulsion, but both suffer from fundamental limitations. Gridded ion sources create good quality beams in terms of energy spread and spatial divergence, but the Child-Langmuir law in the non-neutral acceleration region limits the maximum achievable current density. Hall thrusters avoid this limitation by accelerating ions in quasi-neutral plasma but, as a result, producemore » plumes with high spatial divergence and large energy spread. In addition the more complicated magnetized plasma in the Hall Thruster produces oscillations that can reduce the efficiency of the thruster by increasing electron transport to the anode. We present investigations of three techniques to address the fundamental limitations on the performance of each thruster. First, we propose a method to increase the time-averaged current density (and thus thrust density) produced by a gridded ion source above the Child-Langmuir limit by introducing time-varying boundary conditions. Next, we use an electrostatic plasma lens to focus the Hall thruster plume, and finally we develop a technique to suppress a prominent oscillation that degrades the performance of Hall thrusters. The technique to loosen the constraints on current density from gridded ion thrusters actually applies much more broadly to any space charge limited flow. We investigate the technique with a numerical simulation and by proving a theoretical upper bound. While we ultimately conclude that the approach is not suitable for space propulsion, our results proved useful in another area, providing a benchmark for research into the spontaneously time-dependent current that arises in microdiodes. Next, we experimentally demonstrate a novel approach to reducing plume divergence by using a PL located in the plume of the thruster to focus ions after they were ionized and accelerated. Finally we further improve thruster operation by suppressing a prominent low frequency oscillation in the thruster known as the rotating spoke. The suppression leads to decreased electron transport and more control over the operating conditions in the thruster.« less
Compilation of accelerated bridge construction (ABC) bridges : final report.
DOT National Transportation Integrated Search
2016-01-01
Development of accelerated bridge construction (ABC) technologies has been occurring across the country, many times in : isolation. Although FHWA and others have worked to facilitate communication between these efforts, there was not a : comprehensiv...
Huang, Min; Hou, Yi; Li, Yubao; Wang, Danqing; Zhang, Li
2017-01-01
Abstract A dual network hydrogel made up of polyvinylalcohol (PVA) crosslinked by borax and polyvinylpyrrolidone (PVP) was prepared by means of freezing-thawing circles. Here PVP was incorporated by linking with PVA to form a network structure, while the introduction of borax played the role of crosslinking PVA chains to accelerate the formation of a dual network structure in PVA/PVP composite hydrogel, thus endowing the hydrogel with high mechanical properties. The effects of both PVP and borax on the hydrogels were evaluated by comparing the two systems of PVA/PVP/borax and PVA/borax hydrogels. In the former system, adding 4.0% PVP not only increased the water content and the storage modulus but also enhanced the mechanical strength of the final hydrogel. But an overdose of PVP just as more than 4.0% tended to undermine the structure of hydrogels, and thus deteriorated hydrogels’ properties because of the weakened secondary interaction between PVP and PVA. Likewise, increasing borax could promote the gel crosslinking degree, thus making gels show a decrease in water content and swelling ratio, meanwhile shrinking the pores inside the hydrogels and finally enhancing the mechanical strength of hydrogels prominently. The developed hydrogel with high performances holds great potential for applications in biomedical and industrial fields. PMID:29491822
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sutter, David F.
The 2016 Workshop on Advanced Accelerator Concepts (AAC) was held at the Gaylord Hotel and Conference Center, National Harbor, Maryland, from July 31 through August 5, 2016. This workshop was the seventeenth in a biennial series that began at Los Alamos National Laboratory in 1982 with a workshop on laser acceleration of particles (see AIP Conf. Proc. 91). AAC16 was organized under the sponsorship of the IEEE Council on Superconductivity with financial support from the U. S. Department of Energy Office of High Energy Physics and the National Science Foundation. The scope of the AAC Workshop has grown since 1982more » to encompass a broad range of topics related to advancing accelerator science and technology beyond its current scientific and technical limits and is now an internationally acknowledged forum for interdisciplinary discussions on advanced accelerator and beam physics/technology concepts covering the widest possible range of applications. The Workshop continued the trend of growing worldwide participation, attracting world wide participation. The Workshop had a total of 256 attendees comprising (including the U.S.) representatives from 11 countries representing 65 different institutions. Each day’s schedule began with plenary sessions covering broad, cross disciplinary interests or general tutorial topics as selected by the Program Committee, followed by a break out into more narrowly focused working groups. The Workshop was organized into eight Working Groups each with a published statement of topical focus, scope of discussion and goals. A summary of the Working Group activities and conclusions is included in the American Institute of Physics’ (AIP) Conference Proceedings now available as an on line open source document. It has been a long tradition of the AAC workshops to encourage strong student participation. This is accomplished in part by subsidizing student attendance, done for this work shop by using funds from the DOE and National Science Foundation to significantly reduce student registration fees. As a result the registered student participation was 75 persons, or 29% of the total attendance of 256 persons, the highest percentage student enrollment the Workshop has ever had. This is the final report for the DOE Office of Science/Office of High Energy Physics grant NO. DE-SC0015635, entitled “Organization of the17th Advanced Accelerator Concepts Workshop by the IEEE.”« less
Studies on Muon Induction Acceleration and an Objective Lens Design for Transmission Muon Microscope
NASA Astrophysics Data System (ADS)
Artikova, Sayyora; Yoshida, Mitsuhiro; Naito, Fujio
Muon acceleration will be accomplished by a set of induction cells, where each increases the energy of the muon beam by an increment of up to 30 kV. The cells are arranged in a linear way resulting in total accelerating voltage of 300 kV. Acceleration time in the linac is about hundred nanoseconds. Induction field calculation is based on an electrostatic approximation. Beam dynamics in the induction accelerator is investigated and final beam focusing on specimen is realized by designing a pole piece lens.
The microspace launcher: first step to the fully air-breathing space launcher
NASA Astrophysics Data System (ADS)
Falempin, F.; Bouchez, M.; Calabro, M.
2009-09-01
A possible application for the high-speed air-breathing propulsion is the fully or partially reusable space launcher. Indeed, by combining the high-speed air-breathing propulsion with a conventional rocket engine (combined cycle or combined propulsion system), it should be possible to improve the average installed specific impulse along the ascent trajectory and then make possible more performing launchers and, hopefully, a fully reusable one. During the last 15 years, a lot of system studies have been performed in France on that subject within the framework of different and consecutive programs. Nevertheless, these studies never clearly demonstrated that a space launcher could take advantage of using a combined propulsion system. During last years, the interest to air-breathing propulsion for space application has been revisited. During this review and taking into account technologies development activities already in progress in Europe, clear priorities have been identified regarding a minimum complementary research and technology program addressing specific needs of space launcher application. It was also clearly identified that there is the need to restart system studies taking advantage of recent progress made regarding knowledge, tools, and technology and focusing on more innovative airframe/propulsion system concepts enabling better trade-off between structural efficiency and propulsion system performance. In that field, a fully axisymmetric configuration has been considered for a microspace launcher (10 kg payload). The vehicle is based on a main stage powered by air-breathing propulsion, combined or not with liquid rocket mode. A "kick stage," powered by a solid rocket engine provides the final acceleration. A preliminary design has been performed for different variants: one using a separated booster and a purely air-breathing main stage, a second one using a booster and a main stage combining air-breathing and rocket mode, a third one without separated booster, the main stage ensuring the initial acceleration in liquid rocket mode and a complementary acceleration phase in rocket mode beyond the air-breathing propulsion system operation. Finally, the liquid rocket engine of this third variant can be replaced by a continuous detonation wave rocket engine. The paper describes the main guidelines for the design of these variants and provides their main characteristics. On this basis, the achievable performance, estimated by trajectory simulation, are detailed.
Hu, Simon; Lustig, Michael; Balakrishnan, Asha; Larson, Peder E. Z.; Bok, Robert; Kurhanewicz, John; Nelson, Sarah J.; Goga, Andrei; Pauly, John M.; Vigneron, Daniel B.
2010-01-01
High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at a high signal-to-noise ratio. Acquisition time limitations due to T1 decay of the hyperpolarized signal require accelerated imaging methods, such as compressed sensing, for optimal speed and spatial coverage. In this paper, the design and testing of a new echo-planar 13C three-dimensional magnetic resonance spectroscopic imaging (MRSI) compressed sensing sequence is presented. The sequence provides up to a factor of 7.53 in acceleration with minimal reconstruction artifacts. The key to the design is employing x and y gradient blips during a fly-back readout to pseudorandomly undersample kf-kx-ky space. The design was validated in simulations and phantom experiments where the limits of undersampling and the effects of noise on the compressed sensing nonlinear reconstruction were tested. Finally, this new pulse sequence was applied in vivo in preclinical studies involving transgenic prostate cancer and transgenic liver cancer murine models to obtain much higher spatial and temporal resolution than possible with conventional echo-planar spectroscopic imaging methods. PMID:20017160
NASA Astrophysics Data System (ADS)
Zuiani, Federico; Vasile, Massimiliano
2015-03-01
This paper presents a set of analytical formulae for the perturbed Keplerian motion of a spacecraft under the effect of a constant control acceleration. The proposed set of formulae can treat control accelerations that are fixed in either a rotating or inertial reference frame. Moreover, the contribution of the zonal harmonic is included in the analytical formulae. It will be shown that the proposed analytical theory allows for the fast computation of long, multi-revolution spirals while maintaining good accuracy. The combined effect of different perturbations and of the shadow regions due to solar eclipse is also included. Furthermore, a simplified control parameterisation is introduced to optimise thrusting patterns with two thrust arcs and two cost arcs per revolution. This simple parameterisation is shown to ensure enough flexibility to describe complex low thrust spirals. The accuracy and speed of the proposed analytical formulae are compared against a full numerical integration with different integration schemes. An averaging technique is then proposed as an application of the analytical formulae. Finally, the paper presents an example of design of an optimal low-thrust spiral to transfer a spacecraft from an elliptical to a circular orbit around the Earth.
Primary propulsion/large space system interaction study
NASA Technical Reports Server (NTRS)
Coyner, J. V.; Dergance, R. H.; Robertson, R. I.; Wiggins, J. V.
1981-01-01
An interaction study was conducted between propulsion systems and large space structures to determine the effect of low thrust primary propulsion system characteristics on the mass, area, and orbit transfer characteristics of large space systems (LSS). The LSS which were considered would be deployed from the space shuttle orbiter bay in low Earth orbit, then transferred to geosynchronous equatorial orbit by their own propulsion systems. The types of structures studied were the expandable box truss, hoop and column, and wrap radial rib each with various surface mesh densities. The impact of the acceleration forces on system sizing was determined and the effects of single point, multipoint, and transient thrust applications were examined. Orbit transfer strategies were analyzed to determine the required velocity increment, burn time, trip time, and payload capability over a range of final acceleration levels. Variables considered were number of perigee burns, delivered specific impulse, and constant thrust and constant acceleration modes of propulsion. Propulsion stages were sized for four propellant combinations; oxygen/hydrogen, oxygen/methane, oxygen/kerosene, and nitrogen tetroxide/monomethylhydrazine, for pump fed and pressure fed engine systems. Two types of tankage configurations were evaluated, minimum length to maximize available payload volume and maximum performance to maximize available payload mass.
NASA Astrophysics Data System (ADS)
Rivlin, Lev A.
2010-08-01
The concept of neutron acceleration in a gradient magnetic field of a 'drifting' standing electromagnetic wave is presented. The promising fields of application of an accelerated directional beam of ultracold neurons, in particular, remote initiation of nuclear reactions, are suggested.
NASA Technical Reports Server (NTRS)
Thompson, D. S.
1986-01-01
The results are presented of a design feasibility study of a self-contained (powered) actuation system for a Shingle Lap Extendible Exit Cone (SLEEC) for Transportation System (STS). The evolution of the SLEEC actuation system design is reviewed, the final design concept is summarized, and the results of the detailed study of the final concept of the actuation system are treated. A conservative design using proven mechanical components was established as a major program priority. The final mechanical design has a very low development risk since the components, which consist of ballscrews, gearing, flexible shaft drives, and aircraft cables, have extensive aerospace applications and a history of proven reliability. The mathematical model studies have shown that little or no power is required to deploy the SLEEC actuation system because acceleration forces and internal pressure from the rocket plume provide the required energies. A speed control brake is incorporated in the design in order to control the rate of deployment.
NASA Technical Reports Server (NTRS)
Kihm, Frederic; Rizzi, Stephen A.; Ferguson, Neil S.; Halfpenny, Andrew
2013-01-01
High cycle fatigue of metals typically occurs through long term exposure to time varying loads which, although modest in amplitude, give rise to microscopic cracks that can ultimately propagate to failure. The fatigue life of a component is primarily dependent on the stress amplitude response at critical failure locations. For most vibration tests, it is common to assume a Gaussian distribution of both the input acceleration and stress response. In real life, however, it is common to experience non-Gaussian acceleration input, and this can cause the response to be non-Gaussian. Examples of non-Gaussian loads include road irregularities such as potholes in the automotive world or turbulent boundary layer pressure fluctuations for the aerospace sector or more generally wind, wave or high amplitude acoustic loads. The paper first reviews some of the methods used to generate non-Gaussian excitation signals with a given power spectral density and kurtosis. The kurtosis of the response is examined once the signal is passed through a linear time invariant system. Finally an algorithm is presented that determines the output kurtosis based upon the input kurtosis, the input power spectral density and the frequency response function of the system. The algorithm is validated using numerical simulations. Direct applications of these results include improved fatigue life estimations and a method to accelerate shaker tests by generating high kurtosis, non-Gaussian drive signals.
Laser-powered dielectric-structures for the production of high-brightness electron and x-ray beams
NASA Astrophysics Data System (ADS)
Travish, Gil; Yoder, Rodney B.
2011-05-01
Laser powered accelerators have been under intensive study for the past decade due to their promise of high gradients and leveraging of rapid technological progress in photonics. Of the various acceleration schemes under examination, those based on dielectric structures may enable the production of relativistic electron beams in breadbox sized systems. When combined with undulators having optical-wavelength periods, these systems could produce high brilliance x-rays which find application in, for instance, medical and industrial imaging. These beams also may open the way for table-top atto-second sciences. Development and testing of these dielectric structures faces a number of challenges including complex beam dynamics, new demands on lasers and optical coupling, beam injection schemes, and fabrication. We describe one approach being pursued at UCLA-the Micro Accelerator Platform (MAP). A structure similar to the MAP has also been designed which produces periodic deflections and acts as an undulator for radiation production, and the prospects for this device will be considered. The lessons learned from the multi-year effort to realize these devices will be presented. Challenges remain with acceleration of sub-relativistic beams, focusing, beam phase stability and extension of these devices to higher beam energies. Our progress in addressing these hurdles will be summarized. Finally, the demands on laser technology and optical coupling will be detailed.
Nanoparticles for Imaging, Sensing, and Therapeutic Intervention
2014-01-01
Nanoparticles have the potential to contribute to new modalities in molecular imaging and sensing as well as in therapeutic interventions. In this Nano Focus article, we identify some of the current challenges and knowledge gaps that need to be confronted to accelerate the developments of various applications. Using specific examples, we journey from the characterization of these complex hybrid nanomaterials; continue with surface design and (bio)physicochemical properties, their fate in biological media and cells, and their potential for cancer treatment; and finally reflect on the role of animal models to predict their behavior in humans. PMID:24641589
Moitessier, N; Englebienne, P; Lee, D; Lawandi, J; Corbeil, C R
2008-01-01
Accelerating the drug discovery process requires predictive computational protocols capable of reducing or simplifying the synthetic and/or combinatorial challenge. Docking-based virtual screening methods have been developed and successfully applied to a number of pharmaceutical targets. In this review, we first present the current status of docking and scoring methods, with exhaustive lists of these. We next discuss reported comparative studies, outlining criteria for their interpretation. In the final section, we describe some of the remaining developments that would potentially lead to a universally applicable docking/scoring method. PMID:18037925
Fatigue Crack Growth in Peened Friction Stir Welds
NASA Technical Reports Server (NTRS)
Forth, Scott C.; Hatamleh, Omar
2008-01-01
Friction stir welding induces residual stresses that accelerates fatigue crack growth in the weld nugget. Shot peening over the weld had little effect on growth rate. Laser peening over the weld retarded the growth rate: Final crack growth rate was comparable to the base, un-welded material. Crack tunneling evident from residual compressive stresses. 2195-T8 fracture surfaces were highly textured. Texturing makes comparisons difficult as the material system is affecting the data as much as the processing. Material usage becoming more common in space applications requiring additional work to develop useful datasets for damage tolerance analyses.
Applications of Electron Linear Induction Accelerators
NASA Astrophysics Data System (ADS)
Westenskow*, Glen; Chen, Yu-Jiuan
Linear Induction Accelerators (LIAs) can readily produce intense electron beams. For example, the ATA accelerator produced a 500 GW beam and the LIU-30 a 4 TW beam (see Chap. 2). Since the induction accelerator concept was proposed in the late 1950s [1, 2], there have been many proposed schemes to convert the beam power to other forms. Categories of applications that have been demonstrated for electron LIAs include:
DOE Office of Scientific and Technical Information (OSTI.GOV)
Joshi, Chan; Mori, W.
2013-10-21
This is the final report on the DOE grant number DE-FG02-92ER40727 titled, “Experimental, Theoretical and Computational Studies of Plasma-Based Concepts for Future High Energy Accelerators.” During this grant period the UCLA program on Advanced Plasma Based Accelerators, headed by Professor C. Joshi has made many key scientific advances and trained a generation of students, many of whom have stayed in this research field and even started research programs of their own. In this final report however, we will focus on the last three years of the grant and report on the scientific progress made in each of the four tasksmore » listed under this grant. Four tasks are focused on: Plasma Wakefield Accelerator Research at FACET, SLAC National Accelerator Laboratory, In House Research at UCLA’s Neptune and 20 TW Laser Laboratories, Laser-Wakefield Acceleration (LWFA) in Self Guided Regime: Experiments at the Callisto Laser at LLNL, and Theory and Simulations. Major scientific results have been obtained in each of the four tasks described in this report. These have led to publications in the prestigious scientific journals, graduation and continued training of high quality Ph.D. level students and have kept the U.S. at the forefront of plasma-based accelerators research field.« less
Application accelerator system having bunch control
Wang, Dunxiong; Krafft, Geoffrey Arthur
1999-01-01
An application accelerator system for monitoring the gain of a free electron laser. Coherent Synchrotron Radiation (CSR) detection techniques are used with a bunch length monitor for ultra short, picosec to several tens of femtosec, electron bunches. The monitor employs an application accelerator, a coherent radiation production device, an optical or beam chopping device, an infrared radiation collection device, a narrow-banding filter, an infrared detection device, and a control.
Overview of Accelerators with Potential Use in Homeland Security
NASA Astrophysics Data System (ADS)
Garnett, Robert W.
Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also be discussed.
Using SRAM Based FPGAs for Power-Aware High Performance Wireless Sensor Networks
Valverde, Juan; Otero, Andres; Lopez, Miguel; Portilla, Jorge; de la Torre, Eduardo; Riesgo, Teresa
2012-01-01
While for years traditional wireless sensor nodes have been based on ultra-low power microcontrollers with sufficient but limited computing power, the complexity and number of tasks of today’s applications are constantly increasing. Increasing the node duty cycle is not feasible in all cases, so in many cases more computing power is required. This extra computing power may be achieved by either more powerful microcontrollers, though more power consumption or, in general, any solution capable of accelerating task execution. At this point, the use of hardware based, and in particular FPGA solutions, might appear as a candidate technology, since though power use is higher compared with lower power devices, execution time is reduced, so energy could be reduced overall. In order to demonstrate this, an innovative WSN node architecture is proposed. This architecture is based on a high performance high capacity state-of-the-art FPGA, which combines the advantages of the intrinsic acceleration provided by the parallelism of hardware devices, the use of partial reconfiguration capabilities, as well as a careful power-aware management system, to show that energy savings for certain higher-end applications can be achieved. Finally, comprehensive tests have been done to validate the platform in terms of performance and power consumption, to proof that better energy efficiency compared to processor based solutions can be achieved, for instance, when encryption is imposed by the application requirements. PMID:22736971
Using SRAM based FPGAs for power-aware high performance wireless sensor networks.
Valverde, Juan; Otero, Andres; Lopez, Miguel; Portilla, Jorge; de la Torre, Eduardo; Riesgo, Teresa
2012-01-01
While for years traditional wireless sensor nodes have been based on ultra-low power microcontrollers with sufficient but limited computing power, the complexity and number of tasks of today's applications are constantly increasing. Increasing the node duty cycle is not feasible in all cases, so in many cases more computing power is required. This extra computing power may be achieved by either more powerful microcontrollers, though more power consumption or, in general, any solution capable of accelerating task execution. At this point, the use of hardware based, and in particular FPGA solutions, might appear as a candidate technology, since though power use is higher compared with lower power devices, execution time is reduced, so energy could be reduced overall. In order to demonstrate this, an innovative WSN node architecture is proposed. This architecture is based on a high performance high capacity state-of-the-art FPGA, which combines the advantages of the intrinsic acceleration provided by the parallelism of hardware devices, the use of partial reconfiguration capabilities, as well as a careful power-aware management system, to show that energy savings for certain higher-end applications can be achieved. Finally, comprehensive tests have been done to validate the platform in terms of performance and power consumption, to proof that better energy efficiency compared to processor based solutions can be achieved, for instance, when encryption is imposed by the application requirements.
Technical Application of Nuclear Fission
NASA Astrophysics Data System (ADS)
Denschlag, J. O.
The chapter is devoted to the practical application of the fission process, mainly in nuclear reactors. After a historical discussion covering the natural reactors at Oklo and the first attempts to build artificial reactors, the fundamental principles of chain reactions are discussed. In this context chain reactions with fast and thermal neutrons are covered as well as the process of neutron moderation. Criticality concepts (fission factor η, criticality factor k) are discussed as well as reactor kinetics and the role of delayed neutrons. Examples of specific nuclear reactor types are presented briefly: research reactors (TRIGA and ILL High Flux Reactor), and some reactor types used to drive nuclear power stations (pressurized water reactor [PWR], boiling water reactor [BWR], Reaktor Bolshoi Moshchnosti Kanalny [RBMK], fast breeder reactor [FBR]). The new concept of the accelerator-driven systems (ADS) is presented. The principle of fission weapons is outlined. Finally, the nuclear fuel cycle is briefly covered from mining, chemical isolation of the fuel and preparation of the fuel elements to reprocessing the spent fuel and conditioning for deposit in a final repository.
High field gradient particle accelerator
Nation, John A.; Greenwald, Shlomo
1989-01-01
A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle.
NASA Astrophysics Data System (ADS)
Del McDaniel, Floyd; Doyle, Barney L.
Jerry Duggan was an experimental MeV-accelerator-based nuclear and atomic physicist who, over the past few decades, played a key role in the important transition of this field from basic to applied physics. His fascination for and application of particle accelerators spanned almost 60 years, and led to important discoveries in the following fields: accelerator-based analysis (accelerator mass spectrometry, ion beam techniques, nuclear-based analysis, nuclear microprobes, neutron techniques); accelerator facilities, stewardship, and technology development; accelerator applications (industrial, medical, security and defense, and teaching with accelerators); applied research with accelerators (advanced synthesis and modification, radiation effects, nanosciences and technology); physics research (atomic and molecular physics, and nuclear physics); and many other areas and applications. Here we describe Jerry’s physics education at the University of North Texas (B. S. and M. S.) and Louisiana State University (Ph.D.). We also discuss his research at UNT, LSU, and Oak Ridge National Laboratory, his involvement with the industrial aspects of accelerators, and his impact on many graduate students, colleagues at UNT and other universities, national laboratories, and industry and acquaintances around the world. Along the way, we found it hard not to also talk about his love of family, sports, fishing, and other recreational activities. While these were significant accomplishments in his life, Jerry will be most remembered for his insight in starting and his industry in maintaining and growing what became one of the most diverse accelerator conferences in the world — the International Conference on the Application of Accelerators in Research and Industry, or what we all know as CAARI. Through this conference, which he ran almost single-handed for decades, Jerry came to know, and became well known by, literally thousands of atomic and nuclear physicists, accelerator engineers and vendors, medical doctors, cultural heritage experts... the list goes on and on. While thousands of his acquaintances already miss Jerry, this is being felt most by his family and us (B.D. and F.D.M).
NASA Astrophysics Data System (ADS)
Del McDaniel, Floyd; Doyle, Barney L.
Jerry Duggan was an experimental MeV-accelerator-based nuclear and atomic physicist who, over the past few decades, played a key role in the important transition of this field from basic to applied physics. His fascination for and application of particle accelerators spanned almost 60 years, and led to important discoveries in the following fields: accelerator-based analysis (accelerator mass spectrometry, ion beam techniques, nuclear-based analysis, nuclear microprobes, neutron techniques); accelerator facilities, stewardship, and technology development; accelerator applications (industrial, medical, security and defense, and teaching with accelerators); applied research with accelerators (advanced synthesis and modification, radiation effects, nanosciences and technology); physics research (atomic and molecular physics, and nuclear physics); and many other areas and applications. Here we describe Jerry's physics education at the University of North Texas (B. S. and M. S.) and Louisiana State University (Ph.D.). We also discuss his research at UNT, LSU, and Oak Ridge National Laboratory, his involvement with the industrial aspects of accelerators, and his impact on many graduate students, colleagues at UNT and other universities, national laboratories, and industry and acquaintances around the world. Along the way, we found it hard not to also talk about his love of family, sports, fishing, and other recreational activities. While these were significant accomplishments in his life, Jerry will be most remembered for his insight in starting and his industry in maintaining and growing what became one of the most diverse accelerator conferences in the world — the International Conference on the Application of Accelerators in Research and Industry, or what we all know as CAARI. Through this conference, which he ran almost single-handed for decades, Jerry came to know, and became well known by, literally thousands of atomic and nuclear physicists, accelerator engineers and vendors, medical doctors, cultural heritage experts... the list goes on and on. While thousands of his acquaintances already miss Jerry, this is being felt most by his family and us (B.D. and F.D.M).
Applications of the Strategic Defense Initiative's compact accelerators
NASA Technical Reports Server (NTRS)
Montanarelli, Nick; Lynch, Ted
1991-01-01
The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators. These accelerators, in turn, have produced spinoffs in several areas: the radio frequency quadrupole linear accelerator (RFQ linac) was recently incorporated into the design of a cancer therapy unit at the Loma Linda University Medical Center, an SDI-sponsored compact induction linear accelerator may replace Cobalt-60 radiation and hazardous ethylene-oxide as a method for sterilizing medical products, and other SDIO-funded accelerators may be used to produce the radioactive isotopes oxygen-15, nitrogen-13, carbon-11, and fluorine-18 for positron emission tomography (PET). Other applications of these accelerators include bomb detection, non-destructive inspection, decomposing toxic substances in contaminated ground water, and eliminating nuclear waste.
Pros and Cons of the Acceleration Scheme (NF-IDS)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bogacz, Alex; Bogacz, Slawomir
The overall goal of the acceleration systems: large acceptance acceleration to 25 GeV and beam shaping can be accomplished by various fixed field accelerators at different stages. They involve three superconducting linacs: a single pass linear Pre-accelerator followed by a pair of multi-pass Recirculating Linear Accelerators (RLA) and finally a nonâ scaling FFAG ring. The present baseline acceleration scenario has been optimized to take maximum advantage of appropriate acceleration scheme at a given stage. Pros and cons of various stages are discussed here in detail. The solenoid based Pre-accelerator offers very large acceptance and facilitates correction of energy gain acrossmore » the bunch and significant longitudinal compression trough induced synchrotron motion. However, far off-crest acceleration reduces the effective acceleration gradient and adds complexity through the requirement of individual RF phase control for each cavity. Close proximity of strong solenoids and superc« less
Acceleration sensitivity of micromachined pressure sensors
NASA Astrophysics Data System (ADS)
August, Richard; Maudie, Theresa; Miller, Todd F.; Thompson, Erik
1999-08-01
Pressure sensors serve a variety of automotive applications, some which may experience high levels of acceleration such as tire pressure monitoring. To design pressure sensors for high acceleration environments it is important to understand their sensitivity to acceleration especially if thick encapsulation layers are used to isolate the device from the hostile environment in which they reside. This paper describes a modeling approach to determine their sensitivity to acceleration that is very general and is applicable to different device designs and configurations. It also describes the results of device testing of a capacitive surface micromachined pressure sensor at constant acceleration levels from 500 to 2000 g's.
Schaefer, Sydney Y; Haaland, Kathleen Y; Sainburg, Robert L
2007-08-01
Recent reports of functional impairment in the 'unaffected' limb of stroke patients have suggested that these deficits vary with the side of lesion. This not only supports the idea that the ipsilateral hemisphere contributes to arm movements, but also implies that such contributions are lateralized. We have previously suggested that the left and right hemispheres are specialized for controlling different features of movement. In reaching movements, the non-dominant arm appears better adapted for achieving accurate final positions and the dominant arm for specifying initial trajectory features, such as movement direction and peak acceleration. The purpose of this study was to determine whether different features of control could characterize ipsilesional motor deficits following stroke. Healthy control subjects and patients with either left- or right-hemisphere damage performed targeted single-joint elbow movements of different amplitudes in their ipsilateral hemispace. We predicted that left-hemisphere damage would produce deficits in specification of initial trajectory features, while right-hemisphere damage would produce deficits in final position accuracy. Consistent with our predictions, patients with left, but not right, hemisphere damage showed reduced modulation of acceleration amplitude. However, patients with right, but not left, hemisphere damage showed significantly larger errors in final position, which corresponded to reduced modulation of acceleration duration. Neither patient group differed from controls in terms of movement speed. Instead, the mechanisms by which speed was specified, through modulation of acceleration amplitude and modulation of acceleration duration, appeared to be differentially affected by left- and right-hemisphere damage. These findings support the idea that each hemisphere contributes differentially to the control of initial trajectory and final position, and that ipsilesional deficits following stroke reflect this lateralization in control.
Application accelerator system having bunch control
Wang, D.; Krafft, G.A.
1999-06-22
An application accelerator system for monitoring the gain of a free electron laser is disclosed. Coherent Synchrotron Radiation (CSR) detection techniques are used with a bunch length monitor for ultra short, picosec to several tens of femtosec, electron bunches. The monitor employs an application accelerator, a coherent radiation production device, an optical or beam chopping device, an infrared radiation collection device, a narrow-banding filter, an infrared detection device, and a control. 1 fig.
Community Project for Accelerator Science and Simulation (ComPASS) Final Report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Cary, John R.; Cowan, Benjamin M.; Veitzer, S. A.
2016-03-04
Tech-X participated across the full range of ComPASS activities, with efforts in the Energy Frontier primarily through modeling of laser plasma accelerators and dielectric laser acceleration, in the Intensity Frontier primarily through electron cloud modeling, and in Uncertainty Quantification being applied to dielectric laser acceleration. In the following we present the progress and status of our activities for the entire period of the ComPASS project for the different areas of Energy Frontier, Intensity Frontier and Uncertainty Quantification.
A Phase Matching, Adiabatic Accelerator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lemery, Francois; Flöttmann, Klaus; Kärtner, Franz
2017-05-01
Tabletop accelerators are a thing of the future. Reducing their size will require scaling down electromagnetic wavelengths; however, without correspondingly high field gradients, particles will be more susceptible to phase-slippage – especially at low energy. We investigate how an adiabatically-tapered dielectric-lined waveguide could maintain phase-matching between the accelerating mode and electron bunch. We benchmark our simple model with CST and implement it into ASTRA; finally we provide a first glimpse into the beam dynamics in a phase-matching accelerator.
Analytical and Numerical Solutions of Generalized Fokker-Planck Equations - Final Report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Prinja, Anil K.
The overall goal of this project was to develop advanced theoretical and numerical techniques to quantitatively describe the spreading of a collimated beam of charged particles in space, in angle, and in energy, as a result of small deflection, small energy transfer Coulomb collisions with the target nuclei and electrons. Such beams arise in several applications of great interest in nuclear engineering, and include electron and ion radiotherapy, ion beam modification of materials, accelerator transmutation of waste, and accelerator production of tritium, to name some important candidates. These applications present unique and difficult modeling challenges, but from the outset aremore » amenable to the language of ''transport theory'', which is very familiar to nuclear engineers and considerably less-so to physicists and material scientists. Thus, our approach has been to adopt a fundamental description based on transport equations, but the forward peakedness associated with charged particle interactions precludes a direct application of solution methods developed for neutral particle transport. Unique problem formulations and solution techniques are necessary to describe the transport and interaction of charged particles. In particular, we have developed the Generalized Fokker-Planck (GFP) approach to describe the angular and radial spreading of a collimated beam and a renormalized transport model to describe the energy-loss straggling of an initially monoenergetic distribution. Both analytic and numerical solutions have been investigated and in particular novel finite element numerical methods have been developed. In the first phase of the project, asymptotic methods were used to develop closed form solutions to the GFP equation for different orders of expansion, and was described in a previous progress report. In this final report we present a detailed description of (i) a novel energy straggling model based on a Fokker-Planck approximation but which is adapted for a multigroup transport setting, and (ii) two unique families of discontinuous finite element schemes, one linear and the other nonlinear.« less
Microscale acceleration history discriminators
Polosky, Marc A.; Plummer, David W.
2002-01-01
A new class of micromechanical acceleration history discriminators is claimed. These discriminators allow the precise differentiation of a wide range of acceleration-time histories, thereby allowing adaptive events to be triggered in response to the severity (or lack thereof) of an external environment. Such devices have applications in airbag activation, and other safety and surety applications.
Overview of accelerators with potential use in homeland security
Garnett, Robert W.
2015-06-18
Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also bemore » discussed.« less
Neuromuscular Control of Rapid Linear Accelerations in Fish
2016-06-22
2014 30-Apr-2015 Approved for Public Release; Distribution Unlimited Final Report: Neuromuscular Control of Rapid Linear Accelerations in Fish The...it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. Tufts University Research... Control of Rapid Linear Accelerations in Fish Report Title In this project, we measured muscle activity, body movements, and flow patterns during linear
Accelerated approval of oncology products: a decade of experience.
Dagher, Ramzi; Johnson, John; Williams, Grant; Keegan, Patricia; Pazdur, Richard
2004-10-20
We review the regulatory history of the accelerated approval process and summarize the U.S. Food and Drug Administration experience with accelerated approvals in oncology. The accelerated approval regulations, promulgated in 1992, allow approval of drugs for serious or life-threatening diseases on the basis of a surrogate endpoint that is reasonably likely to predict clinical benefit, such as survival or symptom benefit, pending completion of studies designed to confirm clinical benefit, referred to as phase 4 commitments, which are required to be conducted with due diligence. From 1992 to 2004, 22 applications involving anticancer drugs or biologics were approved. Of these 22 applications, accelerated approval was granted to 15 on the basis of findings from studies without an active comparator (i.e., single-arm studies or studies comparing two dose levels) and to the remaining seven on the basis of one or more randomized studies. Of the 22 approved applications, six (i.e., applications for dexrazoxane, irinotecan, capecitabine, docetaxel, imatinib mesylate, and oxaliplatin) have had one or more indications converted to regular approval. This review reports information that was presented at an Oncologic Drugs Advisory Committee meeting held in March 2003; it also presents a discussion of accelerated approval study designs, the study populations evaluated in the accelerated approval and confirmatory settings, and the integration of accelerated approval into a comprehensive drug development plan.
Laser Wakefield Acceleration: Structural and Dynamic Studies. Final Technical Report ER40954
DOE Office of Scientific and Technical Information (OSTI.GOV)
Downer, Michael C.
2014-04-30
Particle accelerators enable scientists to study the fundamental structure of the universe, but have become the largest and most expensive of scientific instruments. In this project, we advanced the science and technology of laser-plasma accelerators, which are thousands of times smaller and less expensive than their conventional counterparts. In a laser-plasma accelerator, a powerful laser pulse exerts light pressure on an ionized gas, or plasma, thereby driving an electron density wave, which resembles the wake behind a boat. Electrostatic fields within this plasma wake reach tens of billions of volts per meter, fields far stronger than ordinary non-plasma matter (suchmore » as the matter that a conventional accelerator is made of) can withstand. Under the right conditions, stray electrons from the surrounding plasma become trapped within these “wake-fields”, surf them, and acquire energy much faster than is possible in a conventional accelerator. Laser-plasma accelerators thus might herald a new generation of compact, low-cost accelerators for future particle physics, x-ray and medical research. In this project, we made two major advances in the science of laser-plasma accelerators. The first of these was to accelerate electrons beyond 1 gigaelectronvolt (1 GeV) for the first time. In experimental results reported in Nature Communications in 2013, about 1 billion electrons were captured from a tenuous plasma (about 1/100 of atmosphere density) and accelerated to 2 GeV within about one inch, while maintaining less than 5% energy spread, and spreading out less than ½ milliradian (i.e. ½ millimeter per meter of travel). Low energy spread and high beam collimation are important for applications of accelerators as coherent x-ray sources or particle colliders. This advance was made possible by exploiting unique properties of the Texas Petawatt Laser, a powerful laser at the University of Texas at Austin that produces pulses of 150 femtoseconds (1 femtosecond is 10-15 seconds) in duration and 150 Joules in energy (equivalent to the muzzle energy of a small pistol bullet). This duration was well matched to the natural electron density oscillation period of plasma of 1/100 atmospheric density, enabling efficient excitation of a plasma wake, while this energy was sufficient to drive a high-amplitude wake of the right shape to produce an energetic, collimated electron beam. Continuing research is aimed at increasing electron energy even further, increasing the number of electrons captured and accelerated, and developing applications of the compact, multi-GeV accelerator as a coherent, hard x-ray source for materials science, biomedical imaging and homeland security applications. The second major advance under this project was to develop new methods of visualizing the laser-driven plasma wake structures that underlie laser-plasma accelerators. Visualizing these structures is essential to understanding, optimizing and scaling laser-plasma accelerators. Yet prior to work under this project, computer simulations based on estimated initial conditions were the sole source of detailed knowledge of the complex, evolving internal structure of laser-driven plasma wakes. In this project we developed and demonstrated a suite of optical visualization methods based on well-known methods such as holography, streak cameras, and coherence tomography, but adapted to the ultrafast, light-speed, microscopic world of laser-driven plasma wakes. Our methods output images of laser-driven plasma structures in a single laser shot. We first reported snapshots of low-amplitude laser wakes in Nature Physics in 2006. We subsequently reported images of high-amplitude laser-driven plasma “bubbles”, which are important for producing electron beams with low energy spread, in Physical Review Letters in 2010. More recently, we have figured out how to image laser-driven structures that change shape while propagating in a single laser shot. The latter techniques, which use the methods of computerized tomography, were demonstrated on test objects – e.g. laser-driven filaments in air and glass – and reported in Optics Letters in 2013 and Nature Communications in 2014. Their output is a multi-frame movie rather than a snapshot. Continuing research is aimed at applying these tomographic methods directly to evolving laser-driven plasma accelerator structures in our laboratory, then, once perfected, to exporting them to plasma-based accelerator laboratories around the world as standard in-line metrology instruments.« less
High field gradient particle accelerator
Nation, J.A.; Greenwald, S.
1989-05-30
A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications is disclosed. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle. 10 figs.
Design of photon converter and photoneutron target for High power electron accelerator based BNCT.
Rahmani, Faezeh; Seifi, Samaneh; Anbaran, Hossein Tavakoli; Ghasemi, Farshad
2015-12-01
An electron accelerator, ILU-14, with current of 10 mA and 100 kW in power has been considered as one of the options for neutron source in Boron Neutron Capture Therapy (BNCT). The final design of neutron target has been obtained using MCNPX to optimize the neutron production. Tungsten in strip shape and D2O in cylindrical form have been proposed as the photon converter and the photoneutron target, respectively. In addition calculation of heat deposition in the photon target design has been considered to ensure mechanical stability of target. The results show that about 8.37×10(12) photoneutron/s with average energy of 615 keV can be produced by this neutron source design. In addition, using an appropriate beam shaping assembly an epithermal neutron flux of the order of 1.24×10(8) cm(-2) s(-1) can be obtained for BNCT applications. Copyright © 2015 Elsevier Ltd. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Romanov, A.
Many modern and most future accelerators rely on precise configuration of lattice and trajectory. The Integrable Optics Test Accelerator (IOTA) at Fermilab that is coming to final stages of construction will be used to test advanced approaches of control over particles dynamics. Various experiments planned at IOTA require high flexibility of lattice configuration as well as high precision of lattice and closed orbit control. Dense element placement does not allow to have ideal configuration of diagnostics and correctors for all planned experiments. To overcome this limitations advanced method of lattice an beneficial for other machines. Developed algorithm is based onmore » LOCO approach, extended with various sets of other experimental data, such as dispersion, BPM BPM phase advances, beam shape information from synchrotron light monitors, responses of closed orbit bumps to variations of focusing elements and other. Extensive modeling of corrections for a big number of random seed errors is used to illustrate benefits from developed approach.« less
Femtosecond profiling of shaped x-ray pulses
NASA Astrophysics Data System (ADS)
Hoffmann, M. C.; Grguraš, I.; Behrens, C.; Bostedt, C.; Bozek, J.; Bromberger, H.; Coffee, R.; Costello, J. T.; DiMauro, L. F.; Ding, Y.; Doumy, G.; Helml, W.; Ilchen, M.; Kienberger, R.; Lee, S.; Maier, A. R.; Mazza, T.; Meyer, M.; Messerschmidt, M.; Schorb, S.; Schweinberger, W.; Zhang, K.; Cavalieri, A. L.
2018-03-01
Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fully suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. This achievement completes an important step toward future x-ray pulse shaping techniques.
The development of marine renewable energy in China: prospects, challenges and recommendations
NASA Astrophysics Data System (ADS)
Wang, Ji; Wang, Haifeng; Liu, Yuxin; Chen, Libo; Tang, Jiuting
2018-02-01
In this paper, resources distribution and technology status of tidal energy, wave energy, tidal current energy, ocean thermal energy and salinity gradient energy in China is reviewed, and assessment and advices are given for each category. By analysis, we believe that marine renewable energy is a necessary addition to existent renewable energy to meet the energy demand of the areas and islands where traditional forms of energy are not applicable and it is of great importance in adjusting energy structure of China. This paper describes the potential of marine renewable energy in China, and explores the possible role in future energy systems. As the paper discusses, building on these initiatives, and “realizing” the accelerated development of marine energy, presents a number of challenges. This paper describes a scenario for the accelerated development of marine renewable energy in China from now to 2030. Finally, this paper provides recommendations for future development of marine renewable energy in China.
Hardware Acceleration of Adaptive Neural Algorithms.
DOE Office of Scientific and Technical Information (OSTI.GOV)
James, Conrad D.
As tradit ional numerical computing has faced challenges, researchers have turned towards alternative computing approaches to reduce power - per - computation metrics and improve algorithm performance. Here, we describe an approach towards non - conventional computing that strengthens the connection between machine learning and neuroscience concepts. The Hardware Acceleration of Adaptive Neural Algorithms (HAANA) project ha s develop ed neural machine learning algorithms and hardware for applications in image processing and cybersecurity. While machine learning methods are effective at extracting relevant features from many types of data, the effectiveness of these algorithms degrades when subjected to real - worldmore » conditions. Our team has generated novel neural - inspired approa ches to improve the resiliency and adaptability of machine learning algorithms. In addition, we have also designed and fabricated hardware architectures and microelectronic devices specifically tuned towards the training and inference operations of neural - inspired algorithms. Finally, our multi - scale simulation framework allows us to assess the impact of microelectronic device properties on algorithm performance.« less
NASA Technical Reports Server (NTRS)
Fehn, U.; Elmore, D.; Gove, H. E.; Kubik, P.; Teng, R.; Tubbs, L.
1986-01-01
The measurement of Ca-41 and I-129 utilizing the Rochester Tanden Accelerator Mass Spectrometer (TAMS) is discussed. Ca-41, having a half-life of 100,000 yrs., is of potential use for the dating of ground water as well as of bones in the age range between 50,000 and 1 million yrs. A major problem for the measurement of Ca-41 with TAMS is the fact that calcium does not readily form negative atomic ions. It does, however, form negative molecular ions. The production of CaO ions from compounds such as CaO and CaCO3 and from free Ca molecules sprayed with oxygen gas was studied. A project to utilize I-129 as a tracer for hydrothermal convection in sediment-covered oceanic crust is also briefly described. Finally, plans to use the Os-187/Os-186 ratio for the determination of extraterrestrial material in the Ries crater in Germany are summarized.
Simulating synchrotron radiation in accelerators including diffuse and specular reflections
Dugan, G.; Sagan, D.
2017-02-24
An accurate calculation of the synchrotron radiation flux within the vacuum chamber of an accelerator is needed for a number of applications. These include simulations of electron cloud effects and the design of radiation masking systems. To properly simulate the synchrotron radiation, it is important to include the scattering of the radiation at the vacuum chamber walls. To this end, a program called synrad3d has been developed which simulates the production and propagation of synchrotron radiation using a collection of photons. Photons generated by a charged particle beam are tracked from birth until they strike the vacuum chamber wall wheremore » the photon is either absorbed or scattered. Both specular and diffuse scattering is simulated. If a photon is scattered, it is further tracked through multiple encounters with the wall until it is finally absorbed. This paper describes the synrad3d program, with a focus on the details of its scattering model, and presents some examples of the program’s use.« less
Moly99 Production Facility: Report on Beamline Components, Requirements, Costs
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bishofberger, Kip A.
2015-12-23
In FY14 we completed the design of the beam line for the linear accelerator production design concept. This design included a set of three bending magnets, quadrupole focusing magnets, and octopoles to flatten the beam on target. This design was generic and applicable to multiple different accelerators if necessary. In FY15 we built on that work to create specifications for the individual beam optic elements, including power supply requirements. This report captures the specification of beam line components with initial cost estimates for the NorthStar production facility.This report is organized as follows: The motivation of the beamline design is introducedmore » briefly, along with renderings of the design. After that, a specific list is provided, which accounts for each beamline component, including part numbers and costs, to construct the beamline. After that, this report details the important sections of the beamline and individual components. A final summary and list of follow-on activities completes this report.« less
Framework for Development and Distribution of Hardware Acceleration
NASA Astrophysics Data System (ADS)
Thomas, David B.; Luk, Wayne W.
2002-07-01
This paper describes IGOL, a framework for developing reconfigurable data processing applications. While IGOL was originally designed to target imaging and graphics systems, its structure is sufficiently general to support a broad range of applications. IGOL adopts a four-layer architecture: application layer, operation layer, appliance layer and configuration layer. This architecture is intended to separate and co-ordinate both the development and execution of hardware and software components. Hardware developers can use IGOL as an instance testbed for verification and benchmarking, as well as for distribution. Software application developers can use IGOL to discover hardware accelerated data processors, and to access them in a transparent, non-hardware specific manner. IGOL provides extensive support for the RC1000-PP board via the Handel-C language, and a wide selection of image processing filters have been developed. IGOL also supplies plug-ins to enable such filters to be incorporated in popular applications such as Premiere, Winamp, VirtualDub and DirectShow. Moreover, IGOL allows the automatic use of multiple cards to accelerate an application, demonstrated using DirectShow. To enable transparent acceleration without sacrificing performance, a three-tiered COM (Component Object Model) API has been designed and implemented. This API provides a well-defined and extensible interface which facilitates the development of hardware data processors that can accelerate multiple applications.
DOT National Transportation Integrated Search
1986-09-01
A standard accelerated weathering test using Dimethyl Sulfoxide (DMSO) was developed to simulate the chemical degradation of basaltic rocks. After a thorough study of the parameters affecting the current procedure, such as container geometry, aggrega...
DOT National Transportation Integrated Search
2001-11-01
This report describes the test results of the first project at the Louisiana Transportation Research Center's Accelerated Loading Facility (ALF). In 1995, 9 test lanes were constructed at the Louisiana Pavement Research Facility in Port Allen. These ...
Accelerator-Reactor Coupling for Energy Production in Advanced Nuclear Fuel Cycles
NASA Astrophysics Data System (ADS)
Heidet, Florent; Brown, Nicholas R.; Haj Tahar, Malek
This article is a review of several accelerator-reactor interface issues and nuclear fuel cycle applications of accelerator-driven subcritical systems. The systems considered here have the primary goal of energy production, but that goal is accomplished via a specific application in various proposed nuclear fuel cycles, such as breed-and-burn of fertile material or burning of transuranic material. Several basic principles are reviewed, starting from the proton beam window including the target, blanket, reactor core, and up to the fuel cycle. We focus on issues of interest, such as the impact of the energy required to run the accelerator and associated systems on the potential electricity delivered to the grid. Accelerator-driven systems feature many of the constraints and issues associated with critical reactors, with the added challenges of subcritical operation and coupling to an accelerator. Reliable accelerator operation and avoidance of beam trips are critically important. One interesting challenge is measurement of blanket subcriticality level during operation. We also review the potential benefits of accelerator-driven systems in various nuclear fuel cycle applications. Ultimately, accelerator-driven subcritical systems with the goal of transmutation of transuranic material have lower 100,000-year radioactivity than a critical fast reactor with recycling of uranium and plutonium.
Overview of Accelerator Applications for Security and Defense
Antolak, Arlyn J.
2015-01-01
Particle accelerators play a key role in a broad set of defense and security applications including war-fighter and asset protection, cargo inspection, nonproliferation, materials characterization and stockpile stewardship. Accelerators can replace the high activity radioactive sources that pose a security threat for developing a radiological dispersal device and be used to produce isotopes for medical, industrial, and re-search purposes. Lastly, we present an overview of current and emerging accelerator technologies relevant to addressing the needs of defense and security.
Ferroelectric ceramics in a pyroelectric accelerator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shchagin, A. V., E-mail: shchagin@kipt.kharkov.ua; Belgorod State University, Belgorod 308015; Miroshnik, V. S.
2015-12-07
The applicability of polarized ferroelectric ceramics as a pyroelectric in a pyroelectric accelerator is shown by experiments. The spectra of X-ray radiation of energy up to tens of keV, generated by accelerated electrons, have been measured on heating and cooling of the ceramics in vacuum. It is suggested that curved layers of polarized ferroelectric ceramics be used as elements of ceramic pyroelectric accelerators. Besides, nanotubes and nanowires manufactured from ferroelectric ceramics are proposed for the use in nanometer-scale ceramic pyroelectric nanoaccelerators for future applications in nanotechnologies.
Statistical damage constitutive model for rocks subjected to cyclic stress and cyclic temperature
NASA Astrophysics Data System (ADS)
Zhou, Shu-Wei; Xia, Cai-Chu; Zhao, Hai-Bin; Mei, Song-Hua; Zhou, Yu
2017-10-01
A constitutive model of rocks subjected to cyclic stress-temperature was proposed. Based on statistical damage theory, the damage constitutive model with Weibull distribution was extended. Influence of model parameters on the stress-strain curve for rock reloading after stress-temperature cycling was then discussed. The proposed model was initially validated by rock tests for cyclic stress-temperature and only cyclic stress. Finally, the total damage evolution induced by stress-temperature cycling and reloading after cycling was explored and discussed. The proposed constitutive model is reasonable and applicable, describing well the stress-strain relationship during stress-temperature cycles and providing a good fit to the test results. Elastic modulus in the reference state and the damage induced by cycling affect the shape of reloading stress-strain curve. Total damage induced by cycling and reloading after cycling exhibits three stages: initial slow increase, mid-term accelerated increase, and final slow increase.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Englbrecht, F; Lindner, F; Bin, J
2016-06-15
Purpose: To measure and simulate well-defined electron spectra using a linear accelerator and a permanent-magnetic wide-angle spectrometer to test the performance of a novel reconstruction algorithm for retrieval of unknown electron-sources, in view of application to diagnostics of laser-driven particle acceleration. Methods: Six electron energies (6, 9, 12, 15, 18 and 21 MeV, 40cm × 40cm field-size) delivered by a Siemens Oncor linear accelerator were recorded using a permanent-magnetic wide-angle electron spectrometer (150mT) with a one dimensional slit (0.2mm × 5cm). Two dimensional maps representing beam-energy and entrance-position along the slit were measured using different scintillating screens, read by anmore » online CMOS detector of high resolution (0.048mm × 0.048mm pixels) and large field of view (5cm × 10cm). Measured energy-slit position maps were compared to forward FLUKA simulations of electron transport through the spectrometer, starting from IAEA phase-spaces of the accelerator. The latter ones were validated against measured depth-dose and lateral profiles in water. Agreement of forward simulation and measurement was quantified in terms of position and shape of the signal distribution on the detector. Results: Measured depth-dose distributions and lateral profiles in the water phantom showed good agreement with forward simulations of IAEA phase-spaces, thus supporting usage of this simulation source in the study. Measured energy-slit position maps and those obtained by forward Monte-Carlo simulations showed satisfactory agreement in shape and position. Conclusion: Well-defined electron beams of known energy and shape will provide an ideal scenario to study the performance of a novel reconstruction algorithm using measured and simulated signal. Future work will increase the stability and convergence of the reconstruction-algorithm for unknown electron sources, towards final application to the electrons which drive the interaction of TW-class laser pulses with nanometer thin target foils to accelerate protons and ions to multi-MeV kinetic energy. Cluster of Excellence of the German Research Foundation (DFG) “Munich-Centre for Advanced Photonics”.« less
Optimizing laser-driven proton acceleration from overdense targets
Stockem Novo, A.; Kaluza, M. C.; Fonseca, R. A.; Silva, L. O.
2016-01-01
We demonstrate how to tune the main ion acceleration mechanism in laser-plasma interactions to collisionless shock acceleration, thus achieving control over the final ion beam properties (e. g. maximum energy, divergence, number of accelerated ions). We investigate this technique with three-dimensional particle-in-cell simulations and illustrate a possible experimental realisation. The setup consists of an isolated solid density target, which is preheated by a first laser pulse to initiate target expansion, and a second one to trigger acceleration. The timing between the two laser pulses allows to access all ion acceleration regimes, ranging from target normal sheath acceleration, to hole boring and collisionless shock acceleration. We further demonstrate that the most energetic ions are produced by collisionless shock acceleration, if the target density is near-critical, ne ≈ 0.5 ncr. A scaling of the laser power shows that 100 MeV protons may be achieved in the PW range. PMID:27435449
DOE Office of Scientific and Technical Information (OSTI.GOV)
Poukey, J.W.; Coleman, P.D.; Sanford, T.W.L.
1985-10-01
MABE is a multistage linear electron accelerator which accelerates up to nine beams in parallel. Nominal parameters per beam are 25 kA, final energy 7 MeV, and guide field 20 kG. We report recent progress via theory and simulation in understanding the beam dynamics in such a system. In particular, we emphasize our results on the radial oscillations and emittance growth for a beam passing through a series of accelerating gaps.
Malleable architecture generator for FPGA computing
NASA Astrophysics Data System (ADS)
Gokhale, Maya; Kaba, James; Marks, Aaron; Kim, Jang
1996-10-01
The malleable architecture generator (MARGE) is a tool set that translates high-level parallel C to configuration bit streams for field-programmable logic based computing systems. MARGE creates an application-specific instruction set and generates the custom hardware components required to perform exactly those computations specified by the C program. In contrast to traditional fixed-instruction processors, MARGE's dynamic instruction set creation provides for efficient use of hardware resources. MARGE processes intermediate code in which each operation is annotated by the bit lengths of the operands. Each basic block (sequence of straight line code) is mapped into a single custom instruction which contains all the operations and logic inherent in the block. A synthesis phase maps the operations comprising the instructions into register transfer level structural components and control logic which have been optimized to exploit functional parallelism and function unit reuse. As a final stage, commercial technology-specific tools are used to generate configuration bit streams for the desired target hardware. Technology- specific pre-placed, pre-routed macro blocks are utilized to implement as much of the hardware as possible. MARGE currently supports the Xilinx-based Splash-2 reconfigurable accelerator and National Semiconductor's CLAy-based parallel accelerator, MAPA. The MARGE approach has been demonstrated on systolic applications such as DNA sequence comparison.
Design for dependability: A simulation-based approach. Ph.D. Thesis, 1993
NASA Technical Reports Server (NTRS)
Goswami, Kumar K.
1994-01-01
This research addresses issues in simulation-based system level dependability analysis of fault-tolerant computer systems. The issues and difficulties of providing a general simulation-based approach for system level analysis are discussed and a methodology that address and tackle these issues is presented. The proposed methodology is designed to permit the study of a wide variety of architectures under various fault conditions. It permits detailed functional modeling of architectural features such as sparing policies, repair schemes, routing algorithms as well as other fault-tolerant mechanisms, and it allows the execution of actual application software. One key benefit of this approach is that the behavior of a system under faults does not have to be pre-defined as it is normally done. Instead, a system can be simulated in detail and injected with faults to determine its failure modes. The thesis describes how object-oriented design is used to incorporate this methodology into a general purpose design and fault injection package called DEPEND. A software model is presented that uses abstractions of application programs to study the behavior and effect of software on hardware faults in the early design stage when actual code is not available. Finally, an acceleration technique that combines hierarchical simulation, time acceleration algorithms and hybrid simulation to reduce simulation time is introduced.
DOT National Transportation Integrated Search
1992-09-01
The Louisiana Transportation Research Center has established a Pavement Research Facility (PRF). The core of the PRF is a testing machine that is capable of conducting full-scale simulated and accelerated load testing of pavement materials, construct...
The acceleration of particles at propagating interplanetary shocks
NASA Astrophysics Data System (ADS)
Prinsloo, P. L.; Strauss, R. D. T.
2017-12-01
Enhancements of charged energetic particles are often observed at Earth following the eruption of coronal mass ejections (CMEs) on the Sun. These enhancements are thought to arise from the acceleration of those particles at interplanetary shocks forming ahead of CMEs, propagating into the heliosphere. In this study, we model the acceleration of these energetic particles by solving a set of stochastic differential equations formulated to describe their transport and including the effects of diffusive shock acceleration. The study focuses on how acceleration at halo-CME-driven shocks alter the energy spectra of non-thermal particles, while illustrating how this acceleration process depends on various shock and transport parameters. We finally attempt to establish the relative contributions of different seed populations of energetic particles in the inner heliosphere to observed intensities during selected acceleration events.
Improving particle beam acceleration in plasmas
NASA Astrophysics Data System (ADS)
C. de Sousa, M.; L. Caldas, I.
2018-04-01
The dynamics of wave-particle interactions in magnetized plasmas restricts the wave amplitude to moderate values for particle beam acceleration from rest energy. We analyze how a perturbing invariant robust barrier modifies the phase space of the system and enlarges the wave amplitude interval for particle acceleration. For low values of the wave amplitude, the acceleration becomes effective for particles with initial energy close to the rest energy. For higher values of the wave amplitude, the robust barrier controls chaos in the system and restores the acceleration process. We also determine the best position for the perturbing barrier in phase space in order to increase the final energy of the particles.
On the upscaling of process-based models in deltaic applications
NASA Astrophysics Data System (ADS)
Li, L.; Storms, J. E. A.; Walstra, D. J. R.
2018-03-01
Process-based numerical models are increasingly used to study the evolution of marine and terrestrial depositional environments. Whilst a detailed description of small-scale processes provides an accurate representation of reality, application on geological timescales is restrained by the associated increase in computational time. In order to reduce the computational time, a number of acceleration methods are combined and evaluated for a schematic supply-driven delta (static base level) and an accommodation-driven delta (variable base level). The performance of the combined acceleration methods is evaluated by comparing the morphological indicators such as distributary channel networking and delta volumes derived from the model predictions for various levels of acceleration. The results of the accelerated models are compared to the outcomes from a series of simulations to capture autogenic variability. Autogenic variability is quantified by re-running identical models on an initial bathymetry with 1 cm added noise. The overall results show that the variability of the accelerated models fall within the autogenic variability range, suggesting that the application of acceleration methods does not significantly affect the simulated delta evolution. The Time-scale compression method (the acceleration method introduced in this paper) results in an increased computational efficiency of 75% without adversely affecting the simulated delta evolution compared to a base case. The combination of the Time-scale compression method with the existing acceleration methods has the potential to extend the application range of process-based models towards geologic timescales.
Lu, Xin; Liu, Lizhu; Fan, Ruqin; Luo, Jia; Yan, Shaohua; Rengel, Zed; Zhang, Zhenhua
2017-10-01
Composting is one of the post-treatment methods for phytoremediation plants. Due to a high potential of water hyacinth to accumulate pollutants, the physicochemical parameters, microbial activity as well as fates of copper (Cu) and tetracyclines (TCs) were investigated for the different amended water hyacinth biomass harvested from intensive livestock and poultry wastewater, including unamended water hyacinth (W), water hyacinth amended with peat (WP), and water hyacinth amended with pig manure (WPM) during the composting process. Pig manure application accelerated the composting process as evidenced by an increase of temperature, electrical conductivity (EC), NH 4 -N, as well as functional diversity of microbial communities compared to W and WP treatments. Composting process was slowed down by high Cu, but not by TCs. The addition of peat significantly increased the residual fraction of Cu, while pig manure addition increased available Cu concentration in the final compost. Cu could be effectively transformed into low available (oxidizable) and residual fractions after fermentation. In contrast, less than 0.5% of initial concentrations of TCs were determined at the end of 60-day composting for all treatments in the final composts. The dissipation of TCs was accelerated by the high Cu concentration during composting. Therefore, composting is an effective method for the post-treatment and resource utilization of phytoremediation plants containing Cu and/or TCs.
US Particle Accelerators at Age 50.
ERIC Educational Resources Information Center
Wilson, R. R.
1981-01-01
Reviews the development of accelerators over the past 50 years. Topics include: types of accelerators, including cyclotrons; sociology of accelerators (motivation, financing, construction, and use); impact of war; national laboratories; funding; applications; future projects; foreign projects; and international collaborations. (JN)
Potential applications of the dielectric wakefield accelerators in the SINBAD facility at DESY
NASA Astrophysics Data System (ADS)
Nie, Y. C.; Assmann, R.; Dorda, U.; Marchetti, B.; Weikum, M.; Zhu, J.; Hüning, M.
2016-09-01
Short, high-brightness relativistic electron bunches can drive ultra-high wakefields in the dielectric wakefield accelerators (DWFAs). This effect can be used to generate high power THz coherent Cherenkov radiation, accelerate a witness bunch with gradient two or three orders of magnitude larger than that in the conventional RF linear accelerators, introduce energy modulation within the driving bunch itself, etc. The paper studies potential applications of the DWFAs in the SINBAD facility at DESY. The simulations show that the ultra-short relativistic bunches from the SINBAD injector ARES can excite accelerating wakefields with peak amplitudes as high as GV/m at THz frequencies in proper DWFA structures. In addition, it illustrates that the DWFA structure can serve as a dechirper to compensate the correlated energy spread of the bunches accelerated by the laser plasma wakefield accelerator.
The Detour of an Obstetric Technology: Active Management of Labor Across Cultures.
Maffi, Irene
2016-01-01
Active management of labor (AML) is an obstetric technology developed in Ireland in the 1970s to accelerate labor in nulliparous women. This technology achieved rapid success in Great Britain and in English-speaking countries outside America, which adopted it before many other states around the world. In this article, I explore AML's technical and social characteristics when it was first designed, and then examine its local inflections in a Jordanian and a Swiss maternity hospital to shed light on the ways its transnational circulation modifies its script. I argue that its application is shaped by local material constraints and specific sociocultural configurations, gender regimes, and hospital cultures. Finally, I make a comparative analysis of AML practices in these two settings and in the foundational textbook to disentangle the technical and sociocultural components modeling its local applications.
Biomass torrefaction: A promising pretreatment technology for biomass utilization
NASA Astrophysics Data System (ADS)
Chen, ZhiWen; Wang, Mingfeng; Ren, Yongzhi; Jiang, Enchen; Jiang, Yang; Li, Weizhen
2018-02-01
Torrefaction is an emerging technology also called mild pyrolysis, which has been explored for the pretreatment of biomass to make the biomass more favorable for further utilization. Dry torrefaction (DT) is a pretreatment of biomass in the absence of oxygen under atmospheric pressure and in a temperature range of 200-300 degrees C, while wet torrrefaction (WT) is a method in hydrothermal or hot and high pressure water at the tempertures within 180-260 degrees C. Torrrefied biomass is hydrophobic, with lower moisture contents, increased energy density and higher heating value, which are more comparable to the characteristics of coal. With the improvement in the properties, torrefied biomass mainly has three potential applications: combustion or co-firing, pelletization and gasification. Generally, the torrefaction technology can accelerate the development of biomass utilization technology and finally realize the maximum applications of biomass energy.
A spatial operator algebra for manipulator modeling and control
NASA Technical Reports Server (NTRS)
Rodriguez, G.; Kreutz, K.; Milman, M.
1988-01-01
A powerful new spatial operator algebra for modeling, control, and trajectory design of manipulators is discussed along with its implementation in the Ada programming language. Applications of this algebra to robotics include an operator representation of the manipulator Jacobian matrix; the robot dynamical equations formulated in terms of the spatial algebra, showing the complete equivalence between the recursive Newton-Euler formulations to robot dynamics; the operator factorization and inversion of the manipulator mass matrix which immediately results in O(N) recursive forward dynamics algorithms; the joint accelerations of a manipulator due to a tip contact force; the recursive computation of the equivalent mass matrix as seen at the tip of a manipulator; and recursive forward dynamics of a closed chain system. Finally, additional applications and current research involving the use of the spatial operator algebra are discussed in general terms.
Advances in Large Grain Resonators for the European XFEL
NASA Astrophysics Data System (ADS)
Singer, W.; Aderhold, S.; Iversen, J.; Kreps, G.; Matheisen, A.; Singer, X.; Twarowski, K.; Weise, H.; Pekeler, M.; Scholz, F.; Spaniol, B.; Stiedl, E.
2011-03-01
An overview of the activities within the DESY test program of 1.3 GHz TESLA shape 9-cell Large Grain (LG) resonators for the European XFEL, which have taken place in last 4 years, is presented. Attention is devoted to development of LG disc production and cavity fabrication from this material, focusing in particular on aspects of production at reasonable accuracy and costs. More than 200 LG discs were manufactured, eleven 9-cell resonators produced, partially treated at the company Research Instruments (RI) (former ACCEL) and finally treated and RF tested at DESY. Two of the LG cavities are currently used in the FLASH accelerator operation, which is the best demonstration of the feasibility of the LG application. The program compares large grain material with standard sheet niobium. Some data and perspectives of the LG application are discussed.
Ferrand, Guillaume; Luong, Michel; Cloos, Martijn A; Amadon, Alexis; Wackernagel, Hans
2014-08-01
Transmit arrays have been developed to mitigate the RF field inhomogeneity commonly observed in high field magnetic resonance imaging (MRI), typically above 3T. To this end, the knowledge of the RF complex-valued B1 transmit-sensitivities of each independent radiating element has become essential. This paper details a method to speed up a currently available B1-calibration method. The principle relies on slice undersampling, slice and channel interleaving and kriging, an interpolation method developed in geostatistics and applicable in many domains. It has been demonstrated that, under certain conditions, kriging gives the best estimator of a field in a region of interest. The resulting accelerated sequence allows mapping a complete set of eight volumetric field maps of the human head in about 1 min. For validation, the accuracy of kriging is first evaluated against a well-known interpolation technique based on Fourier transform as well as to a B1-maps interpolation method presented in the literature. This analysis is carried out on simulated and decimated experimental B1 maps. Finally, the accelerated sequence is compared to the standard sequence on a phantom and a volunteer. The new sequence provides B1 maps three times faster with a loss of accuracy limited potentially to about 5%.
NASA Astrophysics Data System (ADS)
Kacprzak, T.; Herbel, J.; Amara, A.; Réfrégier, A.
2018-02-01
Approximate Bayesian Computation (ABC) is a method to obtain a posterior distribution without a likelihood function, using simulations and a set of distance metrics. For that reason, it has recently been gaining popularity as an analysis tool in cosmology and astrophysics. Its drawback, however, is a slow convergence rate. We propose a novel method, which we call qABC, to accelerate ABC with Quantile Regression. In this method, we create a model of quantiles of distance measure as a function of input parameters. This model is trained on a small number of simulations and estimates which regions of the prior space are likely to be accepted into the posterior. Other regions are then immediately rejected. This procedure is then repeated as more simulations are available. We apply it to the practical problem of estimation of redshift distribution of cosmological samples, using forward modelling developed in previous work. The qABC method converges to nearly same posterior as the basic ABC. It uses, however, only 20% of the number of simulations compared to basic ABC, achieving a fivefold gain in execution time for our problem. For other problems the acceleration rate may vary; it depends on how close the prior is to the final posterior. We discuss possible improvements and extensions to this method.
Sinenian, N; Manuel, M J-E; Zylstra, A B; Rosenberg, M; Waugh, C J; Rinderknecht, H G; Casey, D T; Sio, H; Ruszczynski, J K; Zhou, L; Gatu Johnson, M; Frenje, J A; Séguin, F H; Li, C K; Petrasso, R D; Ruiz, C L; Leeper, R J
2012-04-01
The MIT Linear Electrostatic Ion Accelerator (LEIA) generates DD and D(3)He fusion products for the development of nuclear diagnostics for Omega, Z, and the National Ignition Facility (NIF). Significant improvements to the system in recent years are presented. Fusion reaction rates, as high as 10(7) s(-1) and 10(6) s(-1) for DD and D(3)He, respectively, are now well regulated with a new ion source and electronic gas control system. Charged fusion products are more accurately characterized, which allows for better calibration of existing nuclear diagnostics. In addition, in situ measurements of the on-target beam profile, made with a CCD camera, are used to determine the metrology of the fusion-product source for particle-counting applications. Finally, neutron diagnostics development has been facilitated by detailed Monte Carlo N-Particle Transport (MCNP) modeling of neutrons in the accelerator target chamber, which is used to correct for scattering within the system. These recent improvements have resulted in a versatile platform, which continues to support the existing nuclear diagnostics while simultaneously facilitating the development of new diagnostics in aid of the National Ignition Campaign at the National Ignition Facility. © 2012 American Institute of Physics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sinenian, N.; Manuel, M. J.-E.; Zylstra, A. B.
2012-04-15
The MIT Linear Electrostatic Ion Accelerator (LEIA) generates DD and D{sup 3}He fusion products for the development of nuclear diagnostics for Omega, Z, and the National Ignition Facility (NIF). Significant improvements to the system in recent years are presented. Fusion reaction rates, as high as 10{sup 7} s{sup -1} and 10{sup 6} s{sup -1} for DD and D{sup 3}He, respectively, are now well regulated with a new ion source and electronic gas control system. Charged fusion products are more accurately characterized, which allows for better calibration of existing nuclear diagnostics. In addition, in situ measurements of the on-target beam profile,more » made with a CCD camera, are used to determine the metrology of the fusion-product source for particle-counting applications. Finally, neutron diagnostics development has been facilitated by detailed Monte Carlo N-Particle Transport (MCNP) modeling of neutrons in the accelerator target chamber, which is used to correct for scattering within the system. These recent improvements have resulted in a versatile platform, which continues to support the existing nuclear diagnostics while simultaneously facilitating the development of new diagnostics in aid of the National Ignition Campaign at the National Ignition Facility.« less
Central region of SKKUCY-9 compact cyclotron
NASA Astrophysics Data System (ADS)
Jung, S. Y.; Kim, H. W.; Ghergherehchi, M.; Park, J. K.; Chai, J. S.; Kim, S. H.
2014-04-01
The development of a 9 MeV compact cyclotron for the production of radioisotopes for medical applications has been recently completed. The machine accelerates negative hydrogen ions generated from an internal PIG (Penning Ion Gauge) ion source following spiral orbits. Some of the structures designed for early beam acceleration, including a pair of center poles providing ions a circular direction, the head of the ion source, and the electrodes, are located in the center of the cyclotron. In this paper we discuss and evaluate the design of the central region that pulls the ions from the chimney of the ion source and directs them into the equilibrium orbit. The magnetic field produced by the center poles was analyzed using the magnetic solver in OPERA-3D TOSCA, and the phase error and ion equilibrium orbit, which is dependent on the kinetic energy within the designed field, were calculated using CYCLONE v8.4. The electric field produced in the acceleration gap was designed using an electrostatic solver. Then, the single beam trajectory was calculated by our own Cyclotron Beam Dynamics (CBD) code. The early orbits, vertical oscillation, acceptable RF phase and the energy gain during the early turns was evaluated. Final goal was to design the central region by the iterative optimization process and verify it with 1 MeV beam experiment.
DOT National Transportation Integrated Search
1986-09-01
Accelerated laboratory atmospheric exposure simulation tests with an acceleration factor of 50 and extending for a maximum of 2200 wet-dry cycles (6-year exposure equivalent) gave corrosion loss data that agreed fairly well with the field data derive...
Accelerated corrosion test for metal drainage pipes : final report.
DOT National Transportation Integrated Search
1987-06-01
This study represents an attempt to develop an accelerated test which would assist the highway engineer in evaluating the usefulness of a new type of coated steel culvert. The test method was to be short in duration (in the order of days), and the re...
EDITORIAL: Laser and plasma accelerators Laser and plasma accelerators
NASA Astrophysics Data System (ADS)
Bingham, Robert
2009-02-01
This special issue on laser and plasma accelerators illustrates the rapid advancement and diverse applications of laser and plasma accelerators. Plasma is an attractive medium for particle acceleration because of the high electric field it can sustain, with studies of acceleration processes remaining one of the most important areas of research in both laboratory and astrophysical plasmas. The rapid advance in laser and accelerator technology has led to the development of terawatt and petawatt laser systems with ultra-high intensities and short sub-picosecond pulses, which are used to generate wakefields in plasma. Recent successes include the demonstration by several groups in 2004 of quasi-monoenergetic electron beams by wakefields in the bubble regime with the GeV energy barrier being reached in 2006, and the energy doubling of the SLAC high-energy electron beam from 42 to 85 GeV. The electron beams generated by the laser plasma driven wakefields have good spatial quality with energies ranging from MeV to GeV. A unique feature is that they are ultra-short bunches with simulations showing that they can be as short as a few femtoseconds with low-energy spread, making these beams ideal for a variety of applications ranging from novel high-brightness radiation sources for medicine, material science and ultrafast time-resolved radiobiology or chemistry. Laser driven ion acceleration experiments have also made significant advances over the last few years with applications in laser fusion, nuclear physics and medicine. Attention is focused on the possibility of producing quasi-mono-energetic ions with energies ranging from hundreds of MeV to GeV per nucleon. New acceleration mechanisms are being studied, including ion acceleration from ultra-thin foils and direct laser acceleration. The application of wakefields or beat waves in other areas of science such as astrophysics and particle physics is beginning to take off, such as the study of cosmic accelerators considered by Chen et al where the driver, instead of being a laser, is a whistler wave known as the magnetowave plasma accelerator. The application to electron--positron plasmas that are found around pulsars is studied in the paper by Shukla, and to muon acceleration by Peano et al. Electron wakefield experiments are now concentrating on control and optimisation of high-quality beams that can be used as drivers for novel radiation sources. Studies by Thomas et al show that filamentation has a deleterious effect on the production of high quality mono-energetic electron beams and is caused by non-optimal choice of focusing geometry and/or electron density. It is crucial to match the focusing with the right plasma parameters and new types of plasma channels are being developed, such as the magnetically controlled plasma waveguide reported by Froula et al. The magnetic field provides a pressure profile shaping the channel to match the guiding conditions of the incident laser, resulting in predicted electron energies of 3GeV. In the forced laser-wakefield experiment Fang et al show that pump depletion reduces or inhibits the acceleration of electrons. One of the earlier laser acceleration concepts known as the beat wave may be revived due to the work by Kalmykov et al who report on all-optical control of nonlinear focusing of laser beams, allowing for stable propagation over several Rayleigh lengths with pre-injected electrons accelerated beyond 100 MeV. With the increasing number of petawatt lasers, attention is being focused on different acceleration regimes such as stochastic acceleration by counterpropagating laser pulses, the relativistic mirror, or the snow-plough effect leading to single-step acceleration reported by Mendonca. During wakefield acceleration the leading edge of the pulse undergoes frequency downshifting and head erosion as the laser energy is transferred to the wake while the trailing edge of the laser pulse undergoes frequency up-shift. This is commonly known as photon deceleration and acceleration and is the result of a modulational instability. Simulations reported by Trines et al using a photon-in-cell code or wave kinetic code agree extremely well with experimental observation. Ion acceleration is actively studied; for example the papers by Robinson, Macchi, Marita and Tripathi all discuss different types of acceleration mechanisms from direct laser acceleration, Coulombic explosion and double layers. Ion acceleration is an exciting development that may have great promise in oncology. The surprising application is in muon acceleration, demonstrated by Peano et al who show that counterpropagating laser beams with variable frequencies drive a beat structure with variable phase velocity, leading to particle trapping and acceleration with possible application to a future muon collider and neutrino factory. Laser and plasma accelerators remain one of the exciting areas of plasma physics with applications in many areas of science ranging from laser fusion, novel high-brightness radiation sources, particle physics and medicine. The guest editor would like to thank all authors and referees for their invaluable contributions to this special issue.
ERIC Educational Resources Information Center
Edge, R. D.
1974-01-01
Discusses the design of a device which serves to demonstrate the principle of acceleration and phase stability by accelerating gravitationally a ball bearing along a spiral groove. Application of the design principle to the acceleration aspect of a linear accelerator is recommended. (CC)
Embedded Streaming Deep Neural Networks Accelerator With Applications.
Dundar, Aysegul; Jin, Jonghoon; Martini, Berin; Culurciello, Eugenio
2017-07-01
Deep convolutional neural networks (DCNNs) have become a very powerful tool in visual perception. DCNNs have applications in autonomous robots, security systems, mobile phones, and automobiles, where high throughput of the feedforward evaluation phase and power efficiency are important. Because of this increased usage, many field-programmable gate array (FPGA)-based accelerators have been proposed. In this paper, we present an optimized streaming method for DCNNs' hardware accelerator on an embedded platform. The streaming method acts as a compiler, transforming a high-level representation of DCNNs into operation codes to execute applications in a hardware accelerator. The proposed method utilizes maximum computational resources available based on a novel-scheduled routing topology that combines data reuse and data concatenation. It is tested with a hardware accelerator implemented on the Xilinx Kintex-7 XC7K325T FPGA. The system fully explores weight-level and node-level parallelizations of DCNNs and achieves a peak performance of 247 G-ops while consuming less than 4 W of power. We test our system with applications on object classification and object detection in real-world scenarios. Our results indicate high-performance efficiency, outperforming all other presented platforms while running these applications.
Applications of laser wakefield accelerator-based light sources
DOE Office of Scientific and Technical Information (OSTI.GOV)
Albert, Felicie; Thomas, Alec G. R.
Laser-wakefield accelerators (LWFAs) were proposed more than three decades ago, and while they promise to deliver compact, high energy particle accelerators, they will also provide the scientific community with novel light sources. In a LWFA, where an intense laser pulse focused onto a plasma forms an electromagnetic wave in its wake, electrons can be trapped and are now routinely accelerated to GeV energies. From terahertz radiation to gamma-rays, this article reviews light sources from relativistic electrons produced by LWFAs, and discusses their potential applications. Betatron motion, Compton scattering and undulators respectively produce x-rays or gamma-rays by oscillating relativistic electrons inmore » the wakefield behind the laser pulse, a counter-propagating laser field, or a magnetic undulator. Other LWFA-based light sources include bremsstrahlung and terahertz radiation. Here, we first evaluate the performance of each of these light sources, and compare them with more conventional approaches, including radio frequency accelerators or other laser-driven sources. We have then identified applications, which we discuss in details, in a broad range of fields: medical and biological applications, military, defense and industrial applications, and condensed matter and high energy density science.« less
Applications of laser wakefield accelerator-based light sources
Albert, Felicie; Thomas, Alec G. R.
2016-10-01
Laser-wakefield accelerators (LWFAs) were proposed more than three decades ago, and while they promise to deliver compact, high energy particle accelerators, they will also provide the scientific community with novel light sources. In a LWFA, where an intense laser pulse focused onto a plasma forms an electromagnetic wave in its wake, electrons can be trapped and are now routinely accelerated to GeV energies. From terahertz radiation to gamma-rays, this article reviews light sources from relativistic electrons produced by LWFAs, and discusses their potential applications. Betatron motion, Compton scattering and undulators respectively produce x-rays or gamma-rays by oscillating relativistic electrons inmore » the wakefield behind the laser pulse, a counter-propagating laser field, or a magnetic undulator. Other LWFA-based light sources include bremsstrahlung and terahertz radiation. Here, we first evaluate the performance of each of these light sources, and compare them with more conventional approaches, including radio frequency accelerators or other laser-driven sources. We have then identified applications, which we discuss in details, in a broad range of fields: medical and biological applications, military, defense and industrial applications, and condensed matter and high energy density science.« less
NASA Astrophysics Data System (ADS)
Eaton, Russell
2002-01-01
The Department of Energy (DOE), as part of its Superconductivity Program for Electric Systems, is successfully pursuing the development of electric power and industrial devices, incorporating significant high-temperature superconducting (HTS) components or subsystems, through its innovative Superconducting Partnership Initiative (SPI). The objective of the SPI is to accelerate the commercial introduction of the HTS products for a broad range of electric power and industrial applications. DOE's approach to accomplishing the SPI objective is to support cost shared projects carried out by industry led teams. DOE will fund projects to develop HTS devices that are either in (1) the research and development stage (Phase 1), (2) the pre-commercialization stage (Phase II), or (3) the commercial entry stage (Phase III). DOE's industry partners must contribute at least half a project's costs. These teams will include capabilities needed to develop the device as well as to develop the business plan for the commercial product introduction. DOE's partners consist of vertically integrated teams consisting of equipment manufacturers, HTS wire and coil suppliers, national laboratories, and end users, primarily utilities. These partners carry out the multi-year technology development efforts, consisting generally of design, construction, and testing of the HTS system. Finally, commercialization of HTS products will be discussed primarily in terms of benefits these products will have over competing products based upon conventional conductors and the critical need for affordable, practical HTS materials and conductors for these applications. .
CPU-GPU hybrid accelerating the Zuker algorithm for RNA secondary structure prediction applications.
Lei, Guoqing; Dou, Yong; Wan, Wen; Xia, Fei; Li, Rongchun; Ma, Meng; Zou, Dan
2012-01-01
Prediction of ribonucleic acid (RNA) secondary structure remains one of the most important research areas in bioinformatics. The Zuker algorithm is one of the most popular methods of free energy minimization for RNA secondary structure prediction. Thus far, few studies have been reported on the acceleration of the Zuker algorithm on general-purpose processors or on extra accelerators such as Field Programmable Gate-Array (FPGA) and Graphics Processing Units (GPU). To the best of our knowledge, no implementation combines both CPU and extra accelerators, such as GPUs, to accelerate the Zuker algorithm applications. In this paper, a CPU-GPU hybrid computing system that accelerates Zuker algorithm applications for RNA secondary structure prediction is proposed. The computing tasks are allocated between CPU and GPU for parallel cooperate execution. Performance differences between the CPU and the GPU in the task-allocation scheme are considered to obtain workload balance. To improve the hybrid system performance, the Zuker algorithm is optimally implemented with special methods for CPU and GPU architecture. Speedup of 15.93× over optimized multi-core SIMD CPU implementation and performance advantage of 16% over optimized GPU implementation are shown in the experimental results. More than 14% of the sequences are executed on CPU in the hybrid system. The system combining CPU and GPU to accelerate the Zuker algorithm is proven to be promising and can be applied to other bioinformatics applications.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Poukey, J.W.; Coleman, P.D.; Sanford, T.W.L.
1985-01-01
MABE is a multistage linear electron accelerator which accelerates up to nine beams in parallel. Nominal parameters per beam are 25 kA, final energy 7 MeV, and guide field 20 kG. We report recent progress via theory and simulation in understanding the beam dynamics in such a system. In particular, we emphasize our results on the radial oscillations and emittance growth for a beam passing through a series of accelerating gaps. 12 refs., 8 figs.
ACCELERATORS: ENGINES FOR TRAVERSING A LARGE AND OFTEN DIFFICULT LANDSCAPE
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sessler, Andrew M.
2012-08-17
The many applications of accelerators are presented, with pictures and comments, upon the machines and the results obtained with them. Attention is then given to possible future applications, and some remarks are made on the future development of accelerators. In short, the presentation should serve as an introduction to the Conference itself where there shall be many - wonderfully detailed - contributions to all of this.
Superconducting Magnets for Particle Accelerators
Bottura, Luca; Gourlay, Stephen A.; Yamamoto, Akira; ...
2015-11-10
In this study, we summarize the evolution and contributions of superconducting magnets to particle accelerators as chronicled over the last 50 years of Particle Accelerator Conferences (PAC, NA-PAC and IPAC). We begin with an historical overview based primarily on PAC Proceedings augmented with references to key milestones in the development of superconducting magnets for particle accelerators. We then provide some illustrative examples of applications that have occurred over the past 50 years, focusing on those that have either been realized in practice or provided technical development for other projects, with discussion of possible future applications.
Superconducting Magnets for Particle Accelerators
NASA Astrophysics Data System (ADS)
Bottura, Luca; Gourlay, Stephen A.; Yamamoto, Akira; Zlobin, Alexander V.
2016-04-01
In this paper we summarize the evolution and contributions of superconducting magnets to particle accelerators as chronicled over the last 50 years of Particle Accelerator Conferences (PAC, NA-PAC and IPAC). We begin with an historical overview based primarily on PAC Proceedings augmented with references to key milestones in the development of superconducting magnets for particle accelerators. We then provide some illustrative examples of applications that have occurred over the past 50 years, focusing on those that have either been realized in practice or provided technical development for other projects, with discussion of possible future applications.
Guo, Fan; Li, Xiaocan; Li, Hui; ...
2016-02-03
Magnetic reconnection is a leading mechanism for dissipating magnetic energy and accelerating nonthermal particles in Poynting-flux-dominated flows. We investigate nonthermal particle acceleration during magnetic reconnection in a magnetically dominated ion–electron plasma using fully kinetic simulations. For an ion–electron plasma with a total magnetization ofmore » $${\\sigma }_{0}={B}^{2}/(4\\pi n({m}_{i}+{m}_{e}){c}^{2})$$, the magnetization for each species is $${\\sigma }_{i}\\sim {\\sigma }_{0}$$ and $${\\sigma }_{e}\\sim ({m}_{i}/{m}_{e}){\\sigma }_{0}$$, respectively. We have studied the magnetically dominated regime by varying σe = 103–105 with initial ion and electron temperatures $${T}_{i}={T}_{e}=5-20{m}_{e}{c}^{2}$$ and mass ratio $${m}_{i}/{m}_{e}=1-1836$$. Our results demonstrate that reconnection quickly establishes power-law energy distributions for both electrons and ions within several (2–3) light-crossing times. For the cases with periodic boundary conditions, the power-law index is $$1\\lt s\\lt 2$$ for both electrons and ions. The hard spectra limit the power-law energies for electrons and ions to be $${\\gamma }_{{be}}\\sim {\\sigma }_{e}$$ and $${\\gamma }_{{bi}}\\sim {\\sigma }_{i}$$, respectively. The main acceleration mechanism is a Fermi-like acceleration through the drift motions of charged particles. When comparing the spectra for electrons and ions in momentum space, the spectral indices sp are identical as predicted in Fermi acceleration. We also find that the bulk flow can carry a significant amount of energy during the simulations. Finally, we discuss the implication of this study in the context of Poynting-flux dominated jets and pulsar winds, especially the applications for explaining nonthermal high-energy emissions.« less
Halobacterium sp. SP1(1) as a starter culture for accelerating fish sauce fermentation.
Akolkar, A V; Durai, D; Desai, A J
2010-07-01
Application of Halobacterium sp. SP1(1) for the acceleration of fish sauce fermentation. Traditional fish sauce fermentation was mimicked using Halobacterium sp. SP1(1) as starter culture. Protease activity, peptide release and α-amino content (parameters used to monitor the progress of the fermentation) were high at day 10 in tests and day 20 in un-inoculated controls. The total protein and nitrogen contents were also high in tests compared with controls. The amino acid profile observed at the end of fermentation in experimental samples, when compared with the commercial sauce preparation, was found to be better with respect to flavour and aroma contributing amino acids as well as essential amino acid lysine. Microflora analysis of the final fish sauce revealed the absence of any nonhalophilic or halotolerant micro-organisms. The protease-producing halophilic isolates obtained from the fish sauce of eviscerated and uneviscerated controls were identified as Halobacterium sp. F1 and F2, respectively, by 16S rDNA sequence analysis. Exogenous augmentation of Halobacterium sp. SP1(1) accelerated the fish sauce fermentation process with an additive effect on the existing natural microflora present in the fish during fermentation. Halobacterium sp SP1(1), therefore, can be used as an important starter culture for accelerating the fish fermentation process, which is attributed to its extracellular protease. The present study is the first report on use of Halobacterium species as a starter culture for accelerating fish sauce fermentation. Use of halobacterial starter cultures may revolutionize the process in fish sauce industries by reducing the fermentation time and making the process more economical with improved nutritive value of product. Journal compilation © 2009 The Society for Applied Microbiology. No claim to Indian Government works.
Accelerator–Reactor Coupling for Energy Production in Advanced Nuclear Fuel Cycles
DOE Office of Scientific and Technical Information (OSTI.GOV)
Heidet, Florent; Brown, Nicholas R.; Haj Tahar, Malek
2015-01-01
This article is a review of several accelerator-reactor interface issues and nuclear fuel cycle applications of accelerator-driven subcritical systems. The systems considered here have the primary goal of energy production, but that goal is accomplished via a specific application in various proposed nuclear fuel cycles, such as breed-and-burn of fertile material or burning of transuranic material. Several basic principles are reviewed, starting from the proton beam window including the target, blanket, reactor core, and up to the fuel cycle. We focused on issues of interest, e.g. the impact of the energy required to run the accelerator and associated systems onmore » the potential electricity delivered to the grid. Accelerator-driven systems feature many of the constraints and issues associated with critical reactors, with the added challenges of subcritical operation and coupling to an accelerator. Reliable accelerator operation and avoidance of beam trips are a critically important. One interesting challenge is measurement of blanket subcriticality level during operation. We also reviewed the potential benefits of accelerator-driven systems in various nuclear fuel cycle applications. Ultimately, accelerator-driven subcritical systems with the goal of transmutation of transuranic material have lower 100,000-year radioactivity versus a critical fast reactor with recycle of uranium and plutonium.« less
Introduction to spallation physics and spallation-target design
DOE Office of Scientific and Technical Information (OSTI.GOV)
Russell, G.J.; Pitcher, E.J.; Daemen, L.L.
1995-10-01
When coupled with the spallation process in appropriate target materials, high-power accelerators can be used to produce large numbers of neutrons, thus providing an alternate method to the use of nuclear reactors for this purpose. Spallation offers exciting new possibilities for generating intense neutron fluxes for a variety of applications, including: (a) spallation-neutron sources for materials science research; (b) accelerator-based production of tritium; (c) accelerator-based transmutation of waste; (d) accelerator-based destruction of plutonium; and (e) radioisotope production for medical and energy applications. Target design plays a key role in these applications, with neutron production/leakage being strongly dependent on the incidentmore » particle type and energy, and target material and geometry.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kagan, Daniel; Nakar, Ehud; Piran, Tsvi, E-mail: daniel.kagan@mail.huji.ac.il
The maximum synchrotron burnoff limit of 160 MeV represents a fundamental limit to radiation resulting from electromagnetic particle acceleration in one-zone ideal plasmas. In magnetic reconnection, however, particle acceleration and radiation are decoupled because the electric field is larger than the magnetic field in the diffusion region. We carry out two-dimensional particle-in-cell simulations to determine the extent to which magnetic reconnection can produce synchrotron radiation above the burnoff limit. We use the test particle comparison (TPC) method to isolate the effects of cooling by comparing the trajectories and acceleration efficiencies of test particles incident on such a reconnection region withmore » and without cooling them. We find that the cooled and uncooled particle trajectories are typically similar during acceleration in the reconnection region, and derive an effective limit on particle acceleration that is inversely proportional to the average magnetic field experienced by the particle during acceleration. Using the calculated distribution of this average magnetic field as a function of uncooled final particle energy, we find analytically that cooling does not affect power-law particle energy spectra except at energies far above the synchrotron burnoff limit. Finally, we compare fully cooled and uncooled simulations of reconnection, confirming that the synchrotron burnoff limit does not produce a cutoff in the particle energy spectrum. Our results indicate that the TPC method accurately predicts the effects of cooling on particle acceleration in relativistic reconnection, and that, even far above the burnoff limit, the synchrotron energy of radiation produced in reconnection is not limited by cooling.« less
The LeRC rail accelerators: Test designs and diagnostic techniques
NASA Technical Reports Server (NTRS)
Zana, L. M.; Kerslake, W. R.; Sturman, J. C.; Wang, S. Y.; Terdan, F. F.
1983-01-01
The feasibility of using rail accelerators for various in-space and to-space propulsion applications was investigated. A 1 meter, 24 sq mm bore accelerator was designed with the goal of demonstrating projectile velocities of 15 km/sec using a peak current of 200 kA. A second rail accelerator, 1 meter long with a 156.25 sq mm bore, was designed with clear polycarbonate sidewalls to permit visual observation of the plasma arc. A study of available diagnostic techniques and their application to the rail accelerator is presented. Specific topics of discussion include the use of interferometry and spectroscopy to examine the plasma armature as well as the use of optical sensors to measure rail displacement during acceleration. Standard diagnostics such as current and voltage measurements are also discussed.
Overview of graduate training program of John Adams Institute for Accelerator Science
NASA Astrophysics Data System (ADS)
Seryi, Andrei
The John Adams Institute for Accelerator Science is a center of excellence in the UK for advanced and novel accelerator technology, providing expertise, research, development and training in accelerator techniques, and promoting advanced accelerator applications in science and society. We work in JAI on design of novel light sources upgrades of 3-rd generation and novel FELs, on plasma acceleration and its application to industrial and medical fields, on novel energy recovery compact linacs and advanced beam diagnostics, and many other projects. The JAI is based on three universities - University of Oxford, Imperial College London and Royal Holloway University of London. Every year 6 to 10 accelerators science experts, trained via research on cutting edge projects, defend their PhD thesis in JAI partner universities. In this presentation we will overview the research and in particular the highly successful graduate training program in JAI.
The history and future of accelerator radiological protection.
Thomas, R H
2001-01-01
The development of accelerator radiological protection from the mid-1930s, just after the invention of the cyclotron, to the present day is described. Three major themes--physics, personalities and politics--are developed. In the sections describing physics the development of shielding design though measurement, radiation transport calculations, the impact of accelerators on the environment and dosimetry in accelerator radiation fields are described. The discussion is limited to high-energy, high-intensity electron and proton accelerators. The impact of notable personalities on the development of both the basic science and on the accelerator health physics profession itself is described. The important role played by scholars and teachers is discussed. In the final section. which discusses the future of accelerator radiological protection, some emphasis is given to the social and political aspects that must he faced in the years ahead.
Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-13
....Regulations.gov ; or to VA's OMB Desk Officer, OMB Human Resources and Housing Branch, New Executive Office...' Group Life Insurance (SGLI) or Veterans' Group Life Insurance (VGLI) prior to death. If the insured...' Group Life Insurance Accelerated Benefits Option application. The application must include a medical...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jing, C.; Konecny, R.; Antipov, S.
2013-11-18
Efforts by a number of institutions to develop a Dielectric-Loaded Accelerating (DLA) structure capable of supporting high gradient acceleration when driven by an external radio frequency source have been ongoing over the past decade. Single surface resonant multipactor has been previously identified as one of the major limitations on the practical application of DLA structures in electron accelerators. In this paper, we report the results of an experiment that demonstrated suppression of multipactor growth in an X-band DLA structure through the use of an applied axial magnetic field. This represents an advance toward the practical use of DLA structures inmore » many accelerator applications.« less
Pulse - Accelerator Science in Medicine
discoveries in particle accelerator science may lead to unexpected applications for medical diagnosis, healing perhaps to new tools for medical science. National laboratories build particle accelerators for physicists
DOE Office of Scientific and Technical Information (OSTI.GOV)
Xu, Tong; Chen, Min, E-mail: minchen@sjtu.edu.cn; Li, Fei-Yu
2014-01-06
We study incoherent Thomson scattering between an ultrashort laser pulse and an electron beam accelerated from a laser wakefield. The energy chirp effects of the accelerated electron beam on the final radiation spectrum bandwidth are investigated. It is found that the scattered X-ray radiation has the minimum spectrum width and highest intensity as electrons are accelerated up to around the dephasing point. Furthermore, it is proposed that the electron acceleration process inside the wakefield can be studied by use of 90° Thomson scattering. The dephasing position and beam energy chirp can be deduced from the intensity and bandwidth of themore » scattered radiation.« less
Flexible and experimentally feasible shortcut to quantum Zeno dynamic passage
NASA Astrophysics Data System (ADS)
Li, Wenlin; Zhang, Fengyang; Jiang, Yunfeng; Li, Chong; Song, Heshan
2016-10-01
We propose and discuss a theoretical scheme to speed up Zeno dynamic passage by an external acceleration Hamiltonian. This scheme is a flexible and experimentally feasible acceleration because the acceleration Hamiltonian does not adhere rigidly to an invariant relationship, whereas it can be a more general form ∑uj (t)Hcj. Here Hcj can be arbitrarily selected without any limitation, and therefore one can always construct an acceleration Hamiltonian by only using realizable Hcj. Applying our scheme, we finally design an experimentally feasible Hamiltonian as an example to speed up an entanglement preparation passage.
Optics measurement and correction during acceleration with beta-squeeze in RHIC
DOE Office of Scientific and Technical Information (OSTI.GOV)
Liu, C.; Marusic, A.; Minty, M.
2015-05-03
In the past, beam optics correction at RHIC has only taken place at injection and at final energy, with interpolation of corrections partially into the acceleration cycle. Recent measurements of the beam optics during acceleration and squeeze have evidenced significant beta-beats that, if corrected, could minimize undesirable emittance dilutions and maximize the spin polarization of polarized proton beams by avoiding the high-order multipole fields sampled by particles within the bunch. We recently demonstrated successful beam optics corrections during acceleration at RHIC. We verified conclusively the superior control of the beam realized via these corrections
Meeting the needs of our best and brightest: curriculum acceleration in tertiary mathematics
NASA Astrophysics Data System (ADS)
Hannah, John; James, Alex; Montelle, Clemency; Nokes, Jacqui
2011-04-01
For many years, it has been a common practice to recognize students with high potential by according them targeted privileges and opportunities. This includes the practice of allowing students to accelerate their high school programme and, in the case of New Zealand students, to take university courses during their final school years. This work assesses the wisdom of this practice of acceleration in mathematics both for the student and the tertiary institution.
Low-cost bioanalysis on paper-based and its hybrid microfluidic platforms.
Dou, Maowei; Sanjay, Sharma Timilsina; Benhabib, Merwan; Xu, Feng; Li, XiuJun
2015-12-01
Low-cost assays have broad applications ranging from human health diagnostics and food safety inspection to environmental analysis. Hence, low-cost assays are especially attractive for rural areas and developing countries, where financial resources are limited. Recently, paper-based microfluidic devices have emerged as a low-cost platform which greatly accelerates the point of care (POC) analysis in low-resource settings. This paper reviews recent advances of low-cost bioanalysis on paper-based microfluidic platforms, including fully paper-based and paper hybrid microfluidic platforms. In this review paper, we first summarized the fabrication techniques of fully paper-based microfluidic platforms, followed with their applications in human health diagnostics and food safety analysis. Then we highlighted paper hybrid microfluidic platforms and their applications, because hybrid platforms could draw benefits from multiple device substrates. Finally, we discussed the current limitations and perspective trends of paper-based microfluidic platforms for low-cost assays. Copyright © 2015 Elsevier B.V. All rights reserved.
Development and Application of Integrated Optical Sensors for Intense E-Field Measurement
Zeng, Rong; Wang, Bo; Niu, Ben; Yu, Zhanqing
2012-01-01
The measurement of intense E-fields is a fundamental need in various research areas. Integrated optical E-field sensors (IOESs) have important advantages and are potentially suitable for intense E-field detection. This paper comprehensively reviews the development and applications of several types of IOESs over the last 30 years, including the Mach-Zehnder interferometer (MZI), coupler interferometer (CI) and common path interferometer (CPI). The features of the different types of IOESs are compared, showing that the MZI has higher sensitivity, the CI has a controllable optical bias, and the CPI has better temperature stability. More specifically, the improvement work of applying IOESs to intense E-field measurement is illustrated. Finally, typical uses of IOESs in the measurement of intense E-fields are demonstrated, including application areas such as E-fields with different frequency ranges in high-voltage engineering, simulated nuclear electromagnetic pulse in high-power electromagnetic pulses, and ion-accelerating field in high-energy physics. PMID:23112663
ZnO Nanostructures for Tissue Engineering Applications
Laurenti, Marco; Cauda, Valentina
2017-01-01
This review focuses on the most recent applications of zinc oxide (ZnO) nanostructures for tissue engineering. ZnO is one of the most investigated metal oxides, thanks to its multifunctional properties coupled with the ease of preparing various morphologies, such as nanowires, nanorods, and nanoparticles. Most ZnO applications are based on its semiconducting, catalytic and piezoelectric properties. However, several works have highlighted that ZnO nanostructures may successfully promote the growth, proliferation and differentiation of several cell lines, in combination with the rise of promising antibacterial activities. In particular, osteogenesis and angiogenesis have been effectively demonstrated in numerous cases. Such peculiarities have been observed both for pure nanostructured ZnO scaffolds as well as for three-dimensional ZnO-based hybrid composite scaffolds, fabricated by additive manufacturing technologies. Therefore, all these findings suggest that ZnO nanostructures represent a powerful tool in promoting the acceleration of diverse biological processes, finally leading to the formation of new living tissue useful for organ repair. PMID:29113133
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bilheux, Hassina Z; Bilheux, Jean-Christophe; Tremsin, Anton S
2015-01-01
The Oak Ridge National Laboratory (ORNL) Neutron Sciences Directorate (NScD) has installed a neutron imaging (NI) beam line at the High Flux Isotope Reactor (HFIR) cold guide hall. The CG-1D beam line produces cold neutrons for a broad range of user research spanning from engineering to material research, additive manufacturing, vehicle technologies, archaeology, biology, and plant physiology. Recent efforts have focused on increasing flux and spatial resolution. A series of selected engineering applications is presented here. Historically and for more than four decades, neutron imaging (NI) facilities have been installed exclusively at continuous (i.e. reactor-based) neutron sources rather than atmore » pulsed sources. This is mainly due to (1) the limited number of accelerator-based facilities and therefore the fierce competition for beam lines with neutron scattering instruments, (2) the limited flux available at accelerator-based neutron sources and finally, (3) the lack of high efficiency imaging detector technology capable of time-stamping pulsed neutrons with sufficient time resolution. Recently completed high flux pulsed proton-driven neutron sources such as the ORNL Spallation Neutron Source (SNS) at ORNL and the Japanese Spallation Neutron Source (JSNS) of the Japan Proton Accelerator Research Complex (J-PARC) in Japan produce high neutron fluxes that offer new and unique opportunities for NI techniques. Pulsed-based neutron imaging facilities RADEN and IMAT are currently being built at J-PARC and the Rutherford National Laboratory in the U.K., respectively. ORNL is building a pulsed neutron imaging beam line called VENUS to respond to the U.S. based scientific community. A team composed of engineers, scientists and designers has developed a conceptual design of the future VENUS imaging instrument at the SNS.« less
The radiation fields around a proton therapy facility: A comparison of Monte Carlo simulations
NASA Astrophysics Data System (ADS)
Ottaviano, G.; Picardi, L.; Pillon, M.; Ronsivalle, C.; Sandri, S.
2014-02-01
A proton therapy test facility with a beam current lower than 10 nA in average, and an energy up to 150 MeV, is planned to be sited at the Frascati ENEA Research Center, in Italy. The accelerator is composed of a sequence of linear sections. The first one is a commercial 7 MeV proton linac, from which the beam is injected in a SCDTL (Side Coupled Drift Tube Linac) structure reaching the energy of 52 MeV. Then a conventional CCL (coupled Cavity Linac) with side coupling cavities completes the accelerator. The linear structure has the important advantage that the main radiation losses during the acceleration process occur to protons with energy below 20 MeV, with a consequent low production of neutrons and secondary radiation. From the radiation protection point of view the source of radiation for this facility is then almost completely located at the final target. Physical and geometrical models of the device have been developed and implemented into radiation transport computer codes based on the Monte Carlo method. The scope is the assessment of the radiation field around the main source for supporting the safety analysis. For the assessment independent researchers used two different Monte Carlo computer codes named FLUKA (FLUktuierende KAskade) and MCNPX (Monte Carlo N-Particle eXtended) respectively. Both are general purpose tools for calculations of particle transport and interactions with matter, covering an extended range of applications including proton beam analysis. Nevertheless each one utilizes its own nuclear cross section libraries and uses specific physics models for particle types and energies. The models implemented into the codes are described and the results are presented. The differences between the two calculations are reported and discussed pointing out disadvantages and advantages of each code in the specific application.
Three-dimensional particle simulation of heavy-ion fusion beams
DOE Office of Scientific and Technical Information (OSTI.GOV)
Friedman, A.; Grote, D.P.; Haber, I.
1992-07-01
The beams in a heavy-ion-beam-driven inertial fusion (HIF) accelerator are collisionless, nonneutral plasmas, confined by applied magnetic and electric fields. These space-charge-dominated beams must be focused onto small (few mm) spots at the fusion target, and so preservation of a small emittance is crucial. The nonlinear beam self-fields can lead to emittance growth, and so a self-consistent field description is needed. To this end, a multidimensional particle simulation code, WARP (Friedman {ital et} {ital al}., Part. Accel. {bold 37}-{bold 38}, 131 (1992)), has been developed and is being used to study the transport of HIF beams. The code's three-dimensional (3-D)more » package combines features of an accelerator code and a particle-in-cell plasma simulation. Novel techniques allow it to follow beams through many accelerator elements over long distances and around bends. This paper first outlines the algorithms employed in WARP. A number of applications and corresponding results are then presented. These applications include studies of: beam drift-compression in a misaligned lattice of quadrupole focusing magnets; beam equilibria, and the approach to equilibrium; and the MBE-4 experiment ({ital AIP} {ital Conference} {ital Proceedings} 152 (AIP, New York, 1986), p. 145) recently concluded at Lawrence Berkeley Laboratory (LBL). Finally, 3-D simulations of bent-beam dynamics relevant to the planned Induction Linac Systems Experiments (ILSE) (Fessenden, Nucl. Instrum. Methods Plasma Res. A {bold 278}, 13 (1989)) at LBL are described. Axially cold beams are observed to exhibit little or no root-mean-square emittance growth at midpulse in transiting a (sharp) bend. Axially hot beams, in contrast, do exhibit some emittance growth.« less
NASA Astrophysics Data System (ADS)
Wang, Qiushi; He, Yuping
2016-01-01
The Society of Automotive Engineers issued a test procedure, SAE-J2179, to determine the rearward amplification (RA) of multi-trailer articulated heavy vehicles (MTAHVs). Built upon the procedure, the International Organization for Standardization released the test manoeuvres, ISO-14791, for evaluating directional performance of MTAHVs. For the RA measures, ISO-14791 recommends two single lane-change manoeuvres: (1) an open-loop procedure with a single sine-wave steering input; and (2) a closed-loop manoeuvre with a single sine-wave lateral acceleration input. For an articulated vehicle with active trailer steering (ATS), the RA measure in lateral acceleration under the open-loop manoeuvre was not in good agreement with that under the closed-loop manoeuvre. This observation motivates the research on the applicability of the two manoeuvres for the RA measures of MTAHVs with ATS. It is reported that transient response under the open-loop manoeuvre often leads to asymmetric curve of tractor lateral acceleration [Winkler CB, Fancher PS, Bareket Z, Bogard S, Johnson G, Karamihas S, Mink C. Heavy vehicle size and weight - test procedures for minimum safety performance standards. Final technical report, NHTSA, US DOT, contract DTNH22-87-D-17174, University of Michigan Transportation Research Institute, Report No. UMTRI-92-13; 1992]. To explore the effect of the transient response, a multiple cycle sine-wave steering input (MCSSI) manoeuvre is proposed. Simulation demonstrates that the steady-state RA measures of an MTAHV with and without ATS under the MCSSI manoeuvre are in excellent agreement with those under the closed-loop manoeuvre. It is indicated that between the two manoeuvres by ISO-14791, the closed-loop manoeuvre is more applicable for determining the RA measures of MTAHVs with ATS.
NASA Astrophysics Data System (ADS)
Hochberg, K.; Gröber, S.; Kuhn, J.; Müller, A.
2014-03-01
Here, we show the possibility of analysing circular motion and acceleration using the acceleration sensors of smartphones. For instance, the known linear dependence of the radial acceleration on the distance to the centre (a constant angular frequency) can be shown using multiple smartphones attached to a revolving disc. As a second example, the decrease of the radial acceleration and the rotation frequency due to friction can be measured and fitted with a quadratic function, in accordance with theory. Finally, because the disc is not set up exactly horizontal, each smartphone measures a component of the gravitational acceleration that adds to the radial acceleration during one half of the period and subtracts from the radial acceleration during the other half. Hence, every graph shows a small modulation, which can be used to determine the rotation frequency, thus converting a ‘nuisance effect’ into a source of useful information, making additional measurements with stopwatches or the like unnecessary.
A simulator study on information requirements for precision hovering
NASA Technical Reports Server (NTRS)
Lemons, J. L.; Dukes, T. A.
1975-01-01
A fixed base simulator study of an advanced helicopter instrument display utilizing translational acceleration, velocity and position information is reported. The simulation involved piloting a heavy helicopter using the Integrated Trajectory Error Display (ITED) in a precision hover task. The test series explored two basic areas. The effect on hover accuracy of adding acceleration information was of primary concern. Also of interest was the operators' ability to use degraded information derived from less sophisticated sources. The addition of translational acceleration to a display containing velocity and position information did not appear to improve the hover performance significantly. However, displayed acceleration information seemed to increase the damping of the man machine system. Finally, the pilots could use translational information synthesized from attitude and angular acceleration as effectively as perfect acceleration.
Recent Advances in Catalyst Accelerated Stress Tests for Polymer Electrolyte Membrane Fuel Cells
Stariha, Sarah; Macauley, Natalia; Sneed, Brian T.; ...
2018-03-15
The U.S. Department of Energy (DOE) set the 2020 durability target for polymer electrolyte membrane fuel cell transportation applications at 5000 hours. Since it is impractical to test every fuel cell for this length of time, there is ever increasing interest in developing accelerated stress tests (ASTs) that can accurately simulate the material component degradation in the membrane electrode assembly (MEA) observed under automotive operating conditions, but over a much shorter time frame. In this study, a square-wave catalyst AST was examined that shows a 5X time acceleration factor over the triangle-wave catalyst AST and a 25X time acceleration factormore » over the modified wet drive-cycle catalyst durability protocol, significantly decreasing the testing time. These acceleration factors were correlated to the platinum (Pt) particle size increase and associated decrease in electrochemical surface area (ECSA). This square-wave AST has been adopted by the DOE as a standard protocol to evaluate catalyst durability. We also compare three catalyst-durability protocols using state-of-the-art platinum-cobalt catalysts supported on high surface area carbon (SOA Pt-Co/HSAC) in the cathode catalyst layer. The results for each of the three tests showed both catalyst particle size increase and transition metal leaching. Moreover the acceleration factors for the alloy catalysts were smaller due to Co leaching being the predominant mechanism of voltage decay in ~5 nm PtCo/C catalysts. Finally, an extremely harsh carbon corrosion AST was run using the same SOA Pt-Co/HSAC catalyst. This showed minimal change in particle size and a low percentage Co loss from the cathode catalyst particles, despite a significant loss in catalyst layer thickness and cell performance. The carbon corrosion rates during these various ASTs were directly measured by monitoring the CO 2 emission from the cathode, further confirming the ability of the square-wave AST to evaluate the electro-catalyst independently of the support.« less
Recent Advances in Catalyst Accelerated Stress Tests for Polymer Electrolyte Membrane Fuel Cells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Stariha, Sarah; Macauley, Natalia; Sneed, Brian T.
The U.S. Department of Energy (DOE) set the 2020 durability target for polymer electrolyte membrane fuel cell transportation applications at 5000 hours. Since it is impractical to test every fuel cell for this length of time, there is ever increasing interest in developing accelerated stress tests (ASTs) that can accurately simulate the material component degradation in the membrane electrode assembly (MEA) observed under automotive operating conditions, but over a much shorter time frame. In this study, a square-wave catalyst AST was examined that shows a 5X time acceleration factor over the triangle-wave catalyst AST and a 25X time acceleration factormore » over the modified wet drive-cycle catalyst durability protocol, significantly decreasing the testing time. These acceleration factors were correlated to the platinum (Pt) particle size increase and associated decrease in electrochemical surface area (ECSA). This square-wave AST has been adopted by the DOE as a standard protocol to evaluate catalyst durability. We also compare three catalyst-durability protocols using state-of-the-art platinum-cobalt catalysts supported on high surface area carbon (SOA Pt-Co/HSAC) in the cathode catalyst layer. The results for each of the three tests showed both catalyst particle size increase and transition metal leaching. Moreover the acceleration factors for the alloy catalysts were smaller due to Co leaching being the predominant mechanism of voltage decay in ~5 nm PtCo/C catalysts. Finally, an extremely harsh carbon corrosion AST was run using the same SOA Pt-Co/HSAC catalyst. This showed minimal change in particle size and a low percentage Co loss from the cathode catalyst particles, despite a significant loss in catalyst layer thickness and cell performance. The carbon corrosion rates during these various ASTs were directly measured by monitoring the CO 2 emission from the cathode, further confirming the ability of the square-wave AST to evaluate the electro-catalyst independently of the support.« less
Plasma Physics Applied (New Book)
NASA Astrophysics Data System (ADS)
Grabbe, Crockett
2007-03-01
0.5cm Plasma physics applications are one of the most rapidly growing fields in engineering & applied science today. The last decade alone has seen the rapid emergence of new applications such as dusty plasmas in the semiconductor and microchip industries, and plasma TVs. In addition, this last decade saw the achievement of the 50-year Lawson breakeven condition for fusion. With new discoveries in space plasma physics and applications to spacecraft for worldwide communication and space weather, as well as new applications being discovered, this diversity is always expanding. The new book Plasma Physics Applied reviews developments in several of these areas. Chapter 1 reviews the content and its authors, and is followed by a more comprehensive review of plasma physics applications in general in Chapter 2. Plasma applications in combustion and environmental uses are presented in Chapter 3. Lightning effects in planetary magnetospheres and potential application are described in Chapter 4. The area of dusty plasmas in both industrial and space plasmas and their applications are reviewed in Chapter 5. The particular area of Coulomb clusters in dusty plasmas is presented in Chapter 6. The variety of approaches to plasma confinement in magnetic devices for fusion are laid out in Chapter 7. Finally, an overview of plasma accelerator developments and their applications are presented in Chapter 8.
CPU-GPU hybrid accelerating the Zuker algorithm for RNA secondary structure prediction applications
2012-01-01
Background Prediction of ribonucleic acid (RNA) secondary structure remains one of the most important research areas in bioinformatics. The Zuker algorithm is one of the most popular methods of free energy minimization for RNA secondary structure prediction. Thus far, few studies have been reported on the acceleration of the Zuker algorithm on general-purpose processors or on extra accelerators such as Field Programmable Gate-Array (FPGA) and Graphics Processing Units (GPU). To the best of our knowledge, no implementation combines both CPU and extra accelerators, such as GPUs, to accelerate the Zuker algorithm applications. Results In this paper, a CPU-GPU hybrid computing system that accelerates Zuker algorithm applications for RNA secondary structure prediction is proposed. The computing tasks are allocated between CPU and GPU for parallel cooperate execution. Performance differences between the CPU and the GPU in the task-allocation scheme are considered to obtain workload balance. To improve the hybrid system performance, the Zuker algorithm is optimally implemented with special methods for CPU and GPU architecture. Conclusions Speedup of 15.93× over optimized multi-core SIMD CPU implementation and performance advantage of 16% over optimized GPU implementation are shown in the experimental results. More than 14% of the sequences are executed on CPU in the hybrid system. The system combining CPU and GPU to accelerate the Zuker algorithm is proven to be promising and can be applied to other bioinformatics applications. PMID:22369626
Generation of low-emittance electron beams in electrostatic accelerators for FEL applications
NASA Astrophysics Data System (ADS)
Chen, Teng; Elias, Luis R.
1995-02-01
This paper reports results of transverse emittance studies and beam propagation in electrostatic accelerators for free electron laser applications. In particular, we discuss emittance growth analysis of a low current electron beam system consisting of a miniature thermoionic electron gun and a National Electrostatics Accelerator (NEC) tube. The emittance growth phenomenon is discussed in terms of thermal effects in the electron gun cathode and aberrations produced by field gradient changes occurring inside the electron gun and throughout the accelerator tube. A method of reducing aberrations using a magnetic solenoidal field is described. Analysis of electron beam emittance was done with the EGUN code. Beam propagation along the accelerator tube was studied using a cylindrically symmetric beam envelope equation that included beam self-fields and the external accelerator fields which were derived from POISSON simulations.
Protein-protein docking on hardware accelerators: comparison of GPU and MIC architectures
2015-01-01
Background The hardware accelerators will provide solutions to computationally complex problems in bioinformatics fields. However, the effect of acceleration depends on the nature of the application, thus selection of an appropriate accelerator requires some consideration. Results In the present study, we compared the effects of acceleration using graphics processing unit (GPU) and many integrated core (MIC) on the speed of fast Fourier transform (FFT)-based protein-protein docking calculation. The GPU implementation performed the protein-protein docking calculations approximately five times faster than the MIC offload mode implementation. The MIC native mode implementation has the advantage in the implementation costs. However, the performance was worse with larger protein pairs because of memory limitations. Conclusion The results suggest that GPU is more suitable than MIC for accelerating FFT-based protein-protein docking applications. PMID:25707855
DOE Office of Scientific and Technical Information (OSTI.GOV)
Garnett, Robert W.
Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also bemore » discussed.« less
Advanced valve-regulated lead-acid batteries for hybrid vehicle applications
NASA Astrophysics Data System (ADS)
Soria, M. L.; Trinidad, F.; Lacadena, J. M.; Sánchez, A.; Valenciano, J.
Future vehicle applications require the development of reliable and long life batteries operating under high-rate partial-state-of-charge (HRPSoC) working conditions. Work presented in this paper deals with the study of different design parameters, manufacturing process and charging conditions of spiral wound valve-regulated lead-acid (VRLA) batteries, in order to improve their reliability and cycle life for hybrid vehicle applications. Test results show that both electrolyte saturation and charge conditions have a strong effect on cycle life at HRPSoC performance, presumably because water loss finally accelerates battery failure, which is linked to irreversible sulphation in the upper part of the negative electrodes. By adding expanded graphite to the negative active mass formulation, increasing the electrolyte saturation degree (>95%) and controlling overcharge during regenerative braking periods (voltage limitation and occasional boosting) it is possible to achieve up to 220,000 cycles at 2.5% DOD, equivalent to 5500 capacity throughput. These results could make lead acid batteries a strong competitor for HEV applications versus other advanced systems such as Ni-MH or Li-ion batteries.
Spheromaks and how plasmas may explain the ultra high energy cosmic ray mystery
NASA Astrophysics Data System (ADS)
Fowler, T. Kenneth; Li, Hui
2016-10-01
> eV or more, finally ejected as ultra high energy cosmic rays (UHECRs) long regarded as one of the mysteries of astrophysics. The acceleration is mainly due to the drift cyclotron loss cone kinetic instability known from plasma research. Experiments and simulations are suggested to verify the acceleration process.
Terrain Following Control Based on an Optimized Spline Model of Aircraft Motion
1975-11-01
constraints, a smooth path through the final data points may not satisfy the norma acceleration constraints between sample points. This latter assertion is...for the reference path in the table. Sae copromise betwen the two effects is required. The accelerations given in Table 7-2 are those measured at the
NASA Astrophysics Data System (ADS)
Tsanakas, John A.; Jaffre, Damien; Sicre, Mathieu; Elouamari, Rachid; Vossier, Alexis; de Salins, Jean-Edouard; Bechou, Laurent; Levrier, Bruno; Perona, Arnaud; Dollet, Alain
2014-09-01
This paper presents a preliminary study upon a novel approach proposed for highly accelerated ageing and reliability optimization of high concentrating photovoltaic (HCPV) cells and assemblies. The intended approach aims to overcome several limitations of some current accelerated ageing tests (AAT) adopted up today, proposing the use of an alternative experimental set-up for performing faster and more realistic thermal cycles, under real sun, without the involvement of environmental chamber. The study also includes specific characterization techniques, before and after each AAT sequence, which respectively provide the initial and final diagnosis on the condition of the tested sample. The acquired data from these diagnostic/characterization methods are then used as indices to determine both quantitatively and qualitatively the severity of degradation and, thus, the ageing level for each tested HCPV assembly or cell sample. Ultimate goal of such "initial diagnosis - AAT - final diagnosis" sequences is to provide the basis for a future work on the reliability analysis of the main degradation mechanisms and confident prediction of failure propagation in HCPV cells, by means of acceleration factor (AF) and mean-time-to-failure (MTTF) estimations.
Anderson acceleration and application to the three-temperature energy equations
NASA Astrophysics Data System (ADS)
An, Hengbin; Jia, Xiaowei; Walker, Homer F.
2017-10-01
The Anderson acceleration method is an algorithm for accelerating the convergence of fixed-point iterations, including the Picard method. Anderson acceleration was first proposed in 1965 and, for some years, has been used successfully to accelerate the convergence of self-consistent field iterations in electronic-structure computations. Recently, the method has attracted growing attention in other application areas and among numerical analysts. Compared with a Newton-like method, an advantage of Anderson acceleration is that there is no need to form the Jacobian matrix. Thus the method is easy to implement. In this paper, an Anderson-accelerated Picard method is employed to solve the three-temperature energy equations, which are a type of strong nonlinear radiation-diffusion equations. Two strategies are used to improve the robustness of the Anderson acceleration method. One strategy is to adjust the iterates when necessary to satisfy the physical constraint. Another strategy is to monitor and, if necessary, reduce the matrix condition number of the least-squares problem in the Anderson-acceleration implementation so that numerical stability can be guaranteed. Numerical results show that the Anderson-accelerated Picard method can solve the three-temperature energy equations efficiently. Compared with the Picard method without acceleration, Anderson acceleration can reduce the number of iterations by at least half. A comparison between a Jacobian-free Newton-Krylov method, the Picard method, and the Anderson-accelerated Picard method is conducted in this paper.
Delivering Sound Energy along an Arbitrary Convex Trajectory
Zhao, Sipei; Hu, Yuxiang; Lu, Jing; Qiu, Xiaojun; Cheng, Jianchun; Burnett, Ian
2014-01-01
Accelerating beams have attracted considerable research interest due to their peculiar properties and various applications. Although there have been numerous research on the generation and application of accelerating light beams, few results have been published on the generation of accelerating acoustic beams. Here we report on the experimental observation of accelerating acoustic beams along arbitrary convex trajectories. The desired trajectory is projected to the spatial phase profile on the boundary which is discretized and sampled spatially. The sound field distribution is formulated with the Green function and the integral equation method. Both the paraxial and the non-paraxial regimes are examined and observed in the experiments. The effect of obstacle scattering in the sound field is also investigated and the results demonstrate that the approach is robust against obstacle scattering. The realization of accelerating acoustic beams will have an impact on various applications where acoustic information and energy are required to be delivered along an arbitrary convex trajectory. PMID:25316353
On accelerated flow of MHD powell-eyring fluid via homotopy analysis method
NASA Astrophysics Data System (ADS)
Salah, Faisal; Viswanathan, K. K.; Aziz, Zainal Abdul
2017-09-01
The aim of this article is to obtain the approximate analytical solution for incompressible magnetohydrodynamic (MHD) flow for Powell-Eyring fluid induced by an accelerated plate. Both constant and variable accelerated cases are investigated. Approximate analytical solution in each case is obtained by using the Homotopy Analysis Method (HAM). The resulting nonlinear analysis is carried out to generate the series solution. Finally, Graphical outcomes of different values of the material constants parameters on the velocity flow field are discussed and analyzed.
High Energy Ion Acceleration by Extreme Laser Radiation Pressure
2017-03-14
and was published in Nuclear Instruments and Methods A [11]. For similar targets, it was found that by monitoring the divergence of a low- energy ...AFRL-AFOSR-UK-TR-2017-0015 High energy ion acceleration by extreme laser radiation pressure Paul McKenna UNIVERSITY OF STRATHCLYDE VIZ ROYAL COLLEGE...MM-YYYY) 14-03-2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 01 May 2013 to 31 Dec 2016 4. TITLE AND SUBTITLE High energy ion acceleration
Online Learning Tools as Supplements for Basic and Clinical Science Education.
Ellman, Matthew S; Schwartz, Michael L
2016-01-01
Undergraduate medical educators are increasingly incorporating online learning tools into basic and clinical science curricula. In this paper, we explore the diversity of online learning tools and consider the range of applications for these tools in classroom and bedside learning. Particular advantages of these tools are highlighted, such as delivering foundational knowledge as part of the "flipped classroom" pedagogy and for depicting unusual physical examination findings and advanced clinical communication skills. With accelerated use of online learning, educators and administrators need to consider pedagogic and practical challenges posed by integrating online learning into individual learning activities, courses, and curricula as a whole. We discuss strategies for faculty development and the role of school-wide resources for supporting and using online learning. Finally, we consider the role of online learning in interprofessional, integrated, and competency-based applications among other contemporary trends in medical education are considered.
Protein Science by DNA Sequencing: How Advances in Molecular Biology Are Accelerating Biochemistry.
Higgins, Sean A; Savage, David F
2018-01-09
A fundamental goal of protein biochemistry is to determine the sequence-function relationship, but the vastness of sequence space makes comprehensive evaluation of this landscape difficult. However, advances in DNA synthesis and sequencing now allow researchers to assess the functional impact of every single mutation in many proteins, but challenges remain in library construction and the development of general assays applicable to a diverse range of protein functions. This Perspective briefly outlines the technical innovations in DNA manipulation that allow massively parallel protein biochemistry and then summarizes the methods currently available for library construction and the functional assays of protein variants. Areas in need of future innovation are highlighted with a particular focus on assay development and the use of computational analysis with machine learning to effectively traverse the sequence-function landscape. Finally, applications in the fundamentals of protein biochemistry, disease prediction, and protein engineering are presented.
Holographic humidity response of slanted gratings in moisture-absorbing acrylamide photopolymer.
Yu, Dan; Liu, Hongpeng; Mao, Dongyao; Geng, Yaohui; Wang, Weibo; Sun, Liping; Lv, Jiang
2015-08-01
Holographic humidity response is characterized in detail using transmission and reflection geometry in moisture-absorbing acrylamide photopolymer. The diffraction spectrum and its temporal evolution at various relative humidity are measured and analyzed. The quantitative relations between relative humidity and holographic properties of slanted gratings are determined. The responsibility of holographic gratings for various relative humidity is observed by the spectrum response of gratings. The extracted humidity constants reflect the applicability of reflection and transmission gratings at different humidity regions. The humidity reversibility experiment is achieved for confirming repeatability of the sensor. These experiments provide a probability for improving the applicability of a holographic humidity sensor. Finally, the extended diffusion model is derived by introducing the expansion coefficient to describe the dynamic swelling process. This work can accelerate development of the holographic sensor and provide a novel strategy for exploring the swelling mechanism of photopolymer.
Online Learning Tools as Supplements for Basic and Clinical Science Education
Ellman, Matthew S.; Schwartz, Michael L.
2016-01-01
Undergraduate medical educators are increasingly incorporating online learning tools into basic and clinical science curricula. In this paper, we explore the diversity of online learning tools and consider the range of applications for these tools in classroom and bedside learning. Particular advantages of these tools are highlighted, such as delivering foundational knowledge as part of the “flipped classroom” pedagogy and for depicting unusual physical examination findings and advanced clinical communication skills. With accelerated use of online learning, educators and administrators need to consider pedagogic and practical challenges posed by integrating online learning into individual learning activities, courses, and curricula as a whole. We discuss strategies for faculty development and the role of school-wide resources for supporting and using online learning. Finally, we consider the role of online learning in interprofessional, integrated, and competency-based applications among other contemporary trends in medical education are considered. PMID:29349323
Accelerator Reactor Coupling for Energy Production in Advanced Nuclear Fuel Cycles
Brown, Nicholas R.; Heidet, Florent; Haj Tahar, Malek
2016-01-01
This article is a review of several accelerator–reactor interface issues and nuclear fuel cycle applications of acceleratordriven subcritical systems. The systems considered here have the primary goal of energy production, but that goal is accomplished via a specific application in various proposed nuclear fuel cycles, such as breed-and-burn of fertile material or burning of transuranic material. Several basic principles are reviewed, starting from the proton beam window including the target, blanket, reactor core, and up to the fuel cycle. We focus on issues of interest, such as the impact of the energy required to run the accelerator and associated systemsmore » on the potential electricity delivered to the grid. Accelerator-driven systems feature many of the constraints and issues associated with critical reactors, with the added challenges of subcritical operation and coupling to an accelerator. Reliable accelerator operation and avoidance of beam trips are critically important. One interesting challenge is measurement of blanket subcriticality level during operation. We also review the potential benefits of accelerator-driven systems in various nuclear fuel cycle applications. Ultimately, accelerator-driven subcritical systems with the goal of transmutation of transuranic material have lower 100,000-year radioactivity than a critical fast reactor with recycling of uranium and plutonium.« less
Multi-chain Markov chain Monte Carlo methods for computationally expensive models
NASA Astrophysics Data System (ADS)
Huang, M.; Ray, J.; Ren, H.; Hou, Z.; Bao, J.
2017-12-01
Markov chain Monte Carlo (MCMC) methods are used to infer model parameters from observational data. The parameters are inferred as probability densities, thus capturing estimation error due to sparsity of the data, and the shortcomings of the model. Multiple communicating chains executing the MCMC method have the potential to explore the parameter space better, and conceivably accelerate the convergence to the final distribution. We present results from tests conducted with the multi-chain method to show how the acceleration occurs i.e., for loose convergence tolerances, the multiple chains do not make much of a difference. The ensemble of chains also seems to have the ability to accelerate the convergence of a few chains that might start from suboptimal starting points. Finally, we show the performance of the chains in the estimation of O(10) parameters using computationally expensive forward models such as the Community Land Model, where the sampling burden is distributed over multiple chains.
DNA methylation age of human tissues and cell types
2013-01-01
Background It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure. Results I developed a multi-tissue predictor of age that allows one to estimate the DNA methylation age of most tissues and cell types. The predictor, which is freely available, was developed using 8,000 samples from 82 Illumina DNA methylation array datasets, encompassing 51 healthy tissues and cell types. I found that DNA methylation age has the following properties: first, it is close to zero for embryonic and induced pluripotent stem cells; second, it correlates with cell passage number; third, it gives rise to a highly heritable measure of age acceleration; and, fourth, it is applicable to chimpanzee tissues. Analysis of 6,000 cancer samples from 32 datasets showed that all of the considered 20 cancer types exhibit significant age acceleration, with an average of 36 years. Low age-acceleration of cancer tissue is associated with a high number of somatic mutations and TP53 mutations, while mutations in steroid receptors greatly accelerate DNA methylation age in breast cancer. Finally, I characterize the 353 CpG sites that together form an aging clock in terms of chromatin states and tissue variance. Conclusions I propose that DNA methylation age measures the cumulative effect of an epigenetic maintenance system. This novel epigenetic clock can be used to address a host of questions in developmental biology, cancer and aging research. PMID:24138928
Implementing Molecular Dynamics on Hybrid High Performance Computers - Three-Body Potentials
DOE Office of Scientific and Technical Information (OSTI.GOV)
Brown, W Michael; Yamada, Masako
The use of coprocessors or accelerators such as graphics processing units (GPUs) has become popular in scientific computing applications due to their low cost, impressive floating-point capabilities, high memory bandwidth, and low electrical power re- quirements. Hybrid high-performance computers, defined as machines with nodes containing more than one type of floating-point processor (e.g. CPU and GPU), are now becoming more prevalent due to these advantages. Although there has been extensive research into methods to efficiently use accelerators to improve the performance of molecular dynamics (MD) employing pairwise potential energy models, little is reported in the literature for models that includemore » many-body effects. 3-body terms are required for many popular potentials such as MEAM, Tersoff, REBO, AIREBO, Stillinger-Weber, Bond-Order Potentials, and others. Because the per-atom simulation times are much higher for models incorporating 3-body terms, there is a clear need for efficient algo- rithms usable on hybrid high performance computers. Here, we report a shared-memory force-decomposition for 3-body potentials that avoids memory conflicts to allow for a deterministic code with substantial performance improvements on hybrid machines. We describe modifications necessary for use in distributed memory MD codes and show results for the simulation of water with Stillinger-Weber on the hybrid Titan supercomputer. We compare performance of the 3-body model to the SPC/E water model when using accelerators. Finally, we demonstrate that our approach can attain a speedup of 5.1 with acceleration on Titan for production simulations to study water droplet freezing on a surface.« less
Mirzajani, N; Ciolini, R; Di Fulvio, A; Esposito, J; d'Errico, F
2014-06-01
Experimental activities are underway at INFN Legnaro National Laboratories (LNL) (Padua, Italy) and Pisa University aimed at angular-dependent neutron energy spectra measurements produced by the (9)Be(p,xn) reaction, under a 5MeV proton beam. This work has been performed in the framework of INFN TRASCO-BNCT project. Bonner Sphere Spectrometer (BSS), based on (6)LiI (Eu) scintillator, was used with the shadow-cone technique. Proper unfolding codes, coupled to BSS response function calculated by Monte Carlo code, were finally used. The main results are reported here. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.
A Survey of Plasmas and Their Applications
NASA Technical Reports Server (NTRS)
Eastman, Timothy E.; Grabbe, C. (Editor)
2006-01-01
Plasmas are everywhere and relevant to everyone. We bath in a sea of photons, quanta of electromagnetic radiation, whose sources (natural and artificial) are dominantly plasma-based (stars, fluorescent lights, arc lamps.. .). Plasma surface modification and materials processing contribute increasingly to a wide array of modern artifacts; e.g., tiny plasma discharge elements constitute the pixel arrays of plasma televisions and plasma processing provides roughly one-third of the steps to produce semiconductors, essential elements of our networking and computing infrastructure. Finally, plasmas are central to many cutting edge technologies with high potential (compact high-energy particle accelerators; plasma-enhanced waste processors; high tolerance surface preparation and multifuel preprocessors for transportation systems; fusion for energy production).
Photonic Crystals-Inhibited Spontaneous Emission: Optical Antennas-Enhanced Spontaneous Emission
NASA Astrophysics Data System (ADS)
Yablonovitch, Eli
Photonic crystals are also part of everyday technological life in opto-electronic telecommunication devices that provide us with internet, cloud storage, and email. But photonic crystals have also been identified in nature, in the coloration of peacocks, parrots, chameleons, butterflies and many other species.In spite of its broad applicability, the original motivation of photonic crystals was to create a ``bandgap'' in which the spontaneous emission of light would be inhibited. Conversely, the opposite is now possible. The ``optical antenna'' can accelerate spontaneous emission. Over 100 years after the radio antenna, we finally have tiny ``optical antennas'' which can act on molecules and quantum dots. Employing optical antennas, spontaneous light emission can become faster than stimulated emission.
Zhu, Hong-Ming; Chen, Jin-Wang; Pan, Xiao-Yin; Sahni, Viraht
2014-01-14
We derive via the interaction "representation" the many-body wave function for harmonically confined electrons in the presence of a magnetostatic field and perturbed by a spatially homogeneous time-dependent electric field-the Generalized Kohn Theorem (GKT) wave function. In the absence of the harmonic confinement - the uniform electron gas - the GKT wave function reduces to the Kohn Theorem wave function. Without the magnetostatic field, the GKT wave function is the Harmonic Potential Theorem wave function. We further prove the validity of the connection between the GKT wave function derived and the system in an accelerated frame of reference. Finally, we provide examples of the application of the GKT wave function.
A fiber-coupled 9xx module with tap water cooling
NASA Astrophysics Data System (ADS)
Schleuning, D.; Anthon, D.; Chryssis, A.; Ryu, G.; Liu, G.; Winhold, H.; Fan, L.; Xu, Z.; Tanbun-Ek, T.; Lehkonen, S.; Acklin, B.
2016-03-01
A novel, 9XX nm fiber-coupled module using arrays of highly reliable laser diode bars has been developed. The module is capable of multi-kW output power in a beam parameter product of 80 mm-mrad. The module incorporates a hard-soldered, isolated stack package compatible with tap-water cooling. Using extensive, accelerated multi-cell life-testing, with more than ten million device hours of test, we have demonstrated a MTTF for emitters of >500,000 hrs. In addition we have qualified the module in hard-pulse on-off cycling and stringent environmental tests. Finally we have demonstrated promising results for a next generation 9xx nm chip design currently in applications and qualification testing
NASA Technical Reports Server (NTRS)
Whorton, M. S.; Eldridge, J. T.; Ferebee, R. C.; Lassiter, J. O.; Redmon, J. W., Jr.
1998-01-01
As a research facility for microgravity science, the International Space Station (ISS) will be used for numerous investigations such as protein crystal growth, combustion, and fluid mechanics experiments which require a quiescent acceleration environment across a broad spectrum of frequencies. These experiments are most sensitive to low-frequency accelerations and can tolerate much higher accelerations at higher frequency. However, the anticipated acceleration environment on ISS significantly exceeds the required acceleration level. The ubiquity and difficulty in characterization of the disturbance sources precludes source isolation, requiring vibration isolation to attenuate the anticipated disturbances to an acceptable level. This memorandum reports the results of research in active control methods for microgravity vibration isolation.
The effect of accelerated aging on the wear of UHMWPE.
Sakoda, H; Fisher, J; Lu, S; Buchanan, F
2001-01-01
Oxidative degradation of UHMWPE has been found to be a cause of elevated wear rate of the polymer in total joint replacement leading to failure of these devices. In order to evaluate long term stability of polymers, various accelerated aging methods have been developed. In this study, wear rates of shelf aged UHMWPE and "accelerated aged" UHMWPE were compared using a multi-directional pin-on-plate wear test machine in order to evaluate the effect of the accelerated aging on wear. Wear factors of the aged materials were found to depend on their density, which is a measure of oxidation level. Finally, accelerated aging was calibrated against shelf aging in terms of wear rate. Copyright 2001 Kluwer Academic Publishers
APPARATUS FOR CONTROL OF HIGH-ENERGY ACCELERATORS
Heard, H.G.
1961-10-24
A particle beam positioning control for a synchrotron or the like is described. The control includes means for selectively impressing a sinusoidal perturbation upon the rising voltage utilized to sweep the frequency of the f-m oscillator which is conventionally coupled to the accelerating electrode of a synchrotron. The perturbation produces a variation in the normal rate of change of frequency of the accelerating voltage applied to the accelerating electrode, resulting in an expansion or contraction of the particle beam orbit diameter during the perturbation. The beam may thus be controlled such that a portion strikes a target positioned close to the expanded or contracted orbit diameter and returns to the original orbit for further acceleration to the final energy. (AEC)
NASA Astrophysics Data System (ADS)
Torrisi, Lorenzo
2018-01-01
Measurements of ion acceleration in plasma produced by fs lasers at intensity of the order of 1018 W/cm2 have been performed in different European laboratories. The forward emission in target-normal-sheath-acceleration (TNSA) regime indicated that the maximum energy is a function of the laser parameters, of the irradiation conditions and of the target properties.In particular the laser intensity and contrast play an important role to maximize the ion acceleration enhancing the conversion efficiency. Also the use of suitable prepulses, focal distances and polarized laser light has important roles. Finally the target composition, surface, geometry and multilayered structure, permit to enhance the electric field driving the forward ion acceleration.Experimental measurements will be reported and discussed.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sumption, Mike D.; Collings, Edward W.
2014-10-29
Our program consisted of the two components: Strand Research and Cable Research, with a focus on Nb3Sn, Bi2212, and YBCO for accelerator magnet applications. We demonstrated a method to refine the grains in Nb3Sn by a factor of two, reaching 45 nm grain sizes, and layer Jcs of 6 kA/mm2 at 12 T. W also measured conductor magnetization for field quality. This has been done both with Nb3Sn conductor, as well as Bi:2212 strand. Work in support of quench studies of YBCO coils was also performed. Cable loss studies in Nb3Sn focused on connecting and comparing persistent magnetization and couplingmore » magnetization for considering their relative impact on HEP machines. In the area of HTS cables, we have investigated both the quench in multistrand YBCO CORC cables, as well as the magnetization of these cables for use in high field magnets. In addition, we examined the magnetic and thermal properties of large (50 T) solenoids.« less
MSL EDL Entry Guidance using the Entry Terminal Point Controller
NASA Technical Reports Server (NTRS)
2006-01-01
The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 10 km of the pre-designated landing site. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last four years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and atmospheric delivery errors are presented. Guidance settings for contingency operations, such as those appropriate for severe dust storm scenarios, are evaluated.
Accelerating atomistic simulations through self-learning bond-boost hyperdynamics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Perez, Danny; Voter, Arthur F
2008-01-01
By altering the potential energy landscape on which molecular dynamics are carried out, the hyperdynamics method of Voter enables one to significantly accelerate the simulation state-to-state dynamics of physical systems. While very powerful, successful application of the method entails solving the subtle problem of the parametrization of the so-called bias potential. In this study, we first clarify the constraints that must be obeyed by the bias potential and demonstrate that fast sampling of the biased landscape is key to the obtention of proper kinetics. We then propose an approach by which the bond boost potential of Miron and Fichthorn canmore » be safely parametrized based on data acquired in the course of a molecular dynamics simulation. Finally, we introduce a procedure, the Self-Learning Bond Boost method, in which the parametrization is step efficiently carried out on-the-fly for each new state that is visited during the simulation by safely ramping up the strength of the bias potential up to its optimal value. The stability and accuracy of the method are demonstrated.« less
Femtosecond profiling of shaped x-ray pulses
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hoffmann, M. C.; Grguras, I.; Behrens, C.
Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fullymore » suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. Furthermore, this achievement completes an important step toward future x-ray pulse shaping techniques.« less
Femtosecond profiling of shaped x-ray pulses
Hoffmann, M. C.; Grguras, I.; Behrens, C.; ...
2018-03-26
Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fullymore » suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. Furthermore, this achievement completes an important step toward future x-ray pulse shaping techniques.« less
Till, Andrew T.; Warsa, James S.; Morel, Jim E.
2018-06-15
The thermal radiative transfer (TRT) equations comprise a radiation equation coupled to the material internal energy equation. Linearization of these equations produces effective, thermally-redistributed scattering through absorption-reemission. In this paper, we investigate the effectiveness and efficiency of Linear-Multi-Frequency-Grey (LMFG) acceleration that has been reformulated for use as a preconditioner to Krylov iterative solution methods. We introduce two general frameworks, the scalar flux formulation (SFF) and the absorption rate formulation (ARF), and investigate their iterative properties in the absence and presence of true scattering. SFF has a group-dependent state size but may be formulated without inner iterations in the presence ofmore » scattering, while ARF has a group-independent state size but requires inner iterations when scattering is present. We compare and evaluate the computational cost and efficiency of LMFG applied to these two formulations using a direct solver for the preconditioners. Finally, this work is novel because the use of LMFG for the radiation transport equation, in conjunction with Krylov methods, involves special considerations not required for radiation diffusion.« less
On the Relativistic Correction of Particles Trajectory in Tandem Type Electrostatic Accelerator
NASA Astrophysics Data System (ADS)
Minárik, Stanislav
2015-08-01
A constant potential is applied to the acceleration of the ion-beam in the tandem type electrostatic accelerator. However, not just one voltage is applied, but instead a number of applications can be made in succession by means of the tandem arrangement of high voltage tubes. This number of voltage applications, which is the number of so-called "stages" of a tandem accelerator, may be two, three, or four, depending on the chosen design. Electrostatic field with approximately constant intensity acts on ions in any stage. In general, non-relativistic dynamics is used for the description of the ion transport in tandem accelerator. Energies of accelerated ions are too low and relativistic effects cannot be commonly observed by standard experimental technique. Estimation of possible relativistic correction of ion trajectories is therefore only a matter of calculation. In this note, we briefly present such calculation. Our aim is to show how using the relativistic dynamics modifies the particles trajectory in tandem type accelerator and what parameters determine this modification.
The LILIA (laser induced light ions acceleration) experiment at LNF
NASA Astrophysics Data System (ADS)
Agosteo, S.; Anania, M. P.; Caresana, M.; Cirrone, G. A. P.; De Martinis, C.; Delle Side, D.; Fazzi, A.; Gatti, G.; Giove, D.; Giulietti, D.; Gizzi, L. A.; Labate, L.; Londrillo, P.; Maggiore, M.; Nassisi, V.; Sinigardi, S.; Tramontana, A.; Schillaci, F.; Scuderi, V.; Turchetti, G.; Varoli, V.; Velardi, L.
2014-07-01
Laser-matter interaction at relativistic intensities opens up new research fields in the particle acceleration and related secondary sources, with immediate applications in medical diagnostics, biophysics, material science, inertial confinement fusion, up to laboratory astrophysics. In particular laser-driven ion acceleration is very promising for hadron therapy once the ion energy will attain a few hundred MeV. The limited value of the energy up to now obtained for the accelerated ions is the drawback of such innovative technique to the real applications. LILIA (laser induced light ions acceleration) is an experiment now running at LNF (Frascati) with the goal of producing a real proton beam able to be driven for significant distances (50-75 cm) away from the interaction point and which will act as a source for further accelerating structure. In this paper the description of the experimental setup, the preliminary results of solid target irradiation and start to end simulation for a post-accelerated beam up to 60 MeV are given.
Accelerators for America's Future
NASA Astrophysics Data System (ADS)
Bai, Mei
2016-03-01
Particle accelerator, a powerful tool to energize beams of charged particles to a desired speed and energy, has been the working horse for investigating the fundamental structure of matter and fundermental laws of nature. Most known examples are the 2-mile long Stanford Linear Accelerator at SLAC, the high energy proton and anti-proton collider Tevatron at FermiLab, and Large Hadron Collider that is currently under operation at CERN. During the less than a century development of accelerator science and technology that led to a dazzling list of discoveries, particle accelerators have also found various applications beyond particle and nuclear physics research, and become an indispensible part of the economy. Today, one can find a particle accelerator at almost every corner of our lives, ranging from the x-ray machine at the airport security to radiation diagnostic and therapy in hospitals. This presentation will give a brief introduction of the applications of this powerful tool in fundermental research as well as in industry. Challenges in accelerator science and technology will also be briefly presented
Multilevel acceleration of scattering-source iterations with application to electron transport
Drumm, Clif; Fan, Wesley
2017-08-18
Acceleration/preconditioning strategies available in the SCEPTRE radiation transport code are described. A flexible transport synthetic acceleration (TSA) algorithm that uses a low-order discrete-ordinates (S N) or spherical-harmonics (P N) solve to accelerate convergence of a high-order S N source-iteration (SI) solve is described. Convergence of the low-order solves can be further accelerated by applying off-the-shelf incomplete-factorization or algebraic-multigrid methods. Also available is an algorithm that uses a generalized minimum residual (GMRES) iterative method rather than SI for convergence, using a parallel sweep-based solver to build up a Krylov subspace. TSA has been applied as a preconditioner to accelerate the convergencemore » of the GMRES iterations. The methods are applied to several problems involving electron transport and problems with artificial cross sections with large scattering ratios. These methods were compared and evaluated by considering material discontinuities and scattering anisotropy. Observed accelerations obtained are highly problem dependent, but speedup factors around 10 have been observed in typical applications.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hanada, M., E-mail: hanada.masaya@jaea.go.jp; Kojima, A.; Tobari, H.
In order to realize negative ion sources and accelerators to be applicable to International Thermonuclear Experimental Reactor and JT-60 Super Advanced, a large cesium (Cs)-seeded negative ion source and a multi-aperture and multi-stage electric acceleration have been developed at Japan Atomic Energy Agency (JAEA). Long pulse production and acceleration of the negative ion beams have been independently carried out. The long pulse production of the high current beams has achieved 100 s at the beam current of 15 A by modifying the JT-60 negative ion source. The pulse duration time is increased three times longer than that before the modification.more » As for the acceleration, a pulse duration time has been also extended two orders of magnitudes from 0.4 s to 60 s. The developments of the negative ion source and acceleration at JAEA are well in progress towards the realization of the negative ion sources and accelerators for fusion applications.« less
Multiple beam induction accelerators for heavy ion fusion
NASA Astrophysics Data System (ADS)
Seidl, Peter A.; Barnard, John J.; Faltens, Andris; Friedman, Alex; Waldron, William L.
2014-01-01
Induction accelerators are appealing for heavy-ion driven inertial fusion energy (HIF) because of their high efficiency and their demonstrated capability to accelerate high beam current (≥10 kA in some applications). For the HIF application, accomplishments and challenges are summarized. HIF research and development has demonstrated the production of single ion beams with the required emittance, current, and energy suitable for injection into an induction linear accelerator. Driver scale beams have been transported in quadrupole channels of the order of 10% of the number of quadrupoles of a driver. We review the design and operation of induction accelerators and the relevant aspects of their use as drivers for HIF. We describe intermediate research steps that would provide the basis for a heavy-ion research facility capable of heating matter to fusion relevant temperatures and densities, and also to test and demonstrate an accelerator architecture that scales well to a fusion power plant.
77 FR 12371 - Proposed Collection; Comment Request for Regulation Project
Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-29
... applicable conventions under the accelerated cost recovery system. DATES: Written comments should be received... INFORMATION: Title: Applicable Conventions Under the Accelerated Cost Recovery System. OMB Number: 1545-1146...-profit organizations, and farms. Estimated Number of Respondents: 700. Estimated Time per Respondent: 6...
Fully vectorial accelerating diffraction-free Helmholtz beams.
Aleahmad, Parinaz; Miri, Mohammad-Ali; Mills, Matthew S; Kaminer, Ido; Segev, Mordechai; Christodoulides, Demetrios N
2012-11-16
We show that new families of diffraction-free nonparaxial accelerating optical beams can be generated by considering the symmetries of the underlying vectorial Helmholtz equation. Both two-dimensional transverse electric and magnetic accelerating wave fronts are possible, capable of moving along elliptic trajectories. Experimental results corroborate these predictions when these waves are launched from either the major or minor axis of the ellipse. In addition, three-dimensional spherical nondiffracting field configurations are presented along with their evolution dynamics. Finally, fully vectorial self-similar accelerating optical wave solutions are obtained via oblate-prolate spheroidal wave functions. In all occasions, these effects are illustrated via pertinent examples.
2010-01-01
Catalytic graphitization for 14C-accelerator mass spectrometry (14C-AMS) produced various forms of elemental carbon. Our high-throughput Zn reduction method (C/Fe = 1:5, 500 °C, 3 h) produced the AMS target of graphite-coated iron powder (GCIP), a mix of nongraphitic carbon and Fe3C. Crystallinity of the AMS targets of GCIP (nongraphitic carbon) was increased to turbostratic carbon by raising the C/Fe ratio from 1:5 to 1:1 and the graphitization temperature from 500 to 585 °C. The AMS target of GCIP containing turbostratic carbon had a large isotopic fractionation and a low AMS ion current. The AMS target of GCIP containing turbostratic carbon also yielded less accurate/precise 14C-AMS measurements because of the lower graphitization yield and lower thermal conductivity that were caused by the higher C/Fe ratio of 1:1. On the other hand, the AMS target of GCIP containing nongraphitic carbon had higher graphitization yield and better thermal conductivity over the AMS target of GCIP containing turbostratic carbon due to optimal surface area provided by the iron powder. Finally, graphitization yield and thermal conductivity were stronger determinants (over graphite crystallinity) for accurate/precise/high-throughput biological, biomedical, and environmental14C-AMS applications such as absorption, distribution, metabolism, elimination (ADME), and physiologically based pharmacokinetics (PBPK) of nutrients, drugs, phytochemicals, and environmental chemicals. PMID:20163100
NASA Technical Reports Server (NTRS)
Foster, John E.
2004-01-01
A plasma accelerator has been conceived for both material-processing and spacecraft-propulsion applications. This accelerator generates and accelerates ions within a very small volume. Because of its compactness, this accelerator could be nearly ideal for primary or station-keeping propulsion for spacecraft having masses between 1 and 20 kg. Because this accelerator is designed to generate beams of ions having energies between 50 and 200 eV, it could also be used for surface modification or activation of thin films.
Design and commissioning of a 16.1 MHz multiharmonic buncher for the reaccelerator at NSCL
NASA Astrophysics Data System (ADS)
Alt, Daniel Maloney
The ReAccelerator (ReA) linear accelerator facility at the National Superconducting Cyclotron Laboratory is a unique resource for the nuclear physics community. The particle fragmentation beam production technique, combined with the ability to stop and then reaccelerate the beam to energies of astrophysical interest, give experimenters an unprecedented range of rare isotopes at energies of nuclear and astrophysical interest. The ReAccelerator also functions as a testbed for technology to be incorporated in the upcoming Facility for Rare Isotope Beams linear accelerator, which will eventually in turn become the beam source for ReA. This prototype nature of the ReAccelerator, however, dictated some design choices which have resulted in a final beam with a time structure that is less than ideal for certain classes of experiments. The cavities and RFQ used in ReA have an operating frequency of 80.5 MHz, which corresponds to a separation between particle bunches at the detectors of 12.4 ns. While this separation is acceptable for many experiments, sensitive time of flight measurements require a greater separation between pulses. As nuclear physics experiments rely on statistics, a solution to increasing bunch separation without simply discarding a large fraction of the beam particles was desired. This document describes the design and construction of such a device, a 16.1 MHz multiharmonic buncher. The first chapter provides backgound information on the NSCL and ReA, and some basic concepts in accelerator physics to lay the groundwork for the project.Next, more specifics are provided on the time structure of accelerated beams, and the experimental motivation for greater separation. The third chapter outlines the basic principles of multiharmonic bunching. In order to evaluate the feasibility of any buncher design, the exact acceptance of the Radiofrequency Quadrupole (RFQ) of the ReAccelerator needed to be empirically measured. Chapter 4 describes the results of that measurement. Chapter 5 outlines the simulations and calculations that went into the design choices for this particular buncher, incorporating the results of the RFQ measurements. The next two chapters describe the construction, installation, and testing of the device, and give experimental results. Finally, Chapter 8 summarizes the project and the final steps which need to be undertaken to make the device a simple to use asset for future experimentalists at ReA.
Application of JLab 12GeV helium refrigeration system for the FRIB accelerator at MSU
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ganni, Venkatarao; Knudsen, Peter N.; Arenius, Dana M.
The planned approach to have a turnkey helium refrigeration system for the MSU-FRIB accelerator system, encompassing the design, fabrication, installation and commissioning of the 4.5-K refrigerator cold box(es), cold compression system, warm compression system, gas management, oil removal and utility/ancillary systems, was found to be cost prohibitive. Following JLab’s suggestion, MSU-FRIB accelerator management made a formal request to evaluate the applicability of the recently designed 12GeV JLab cryogenic system for this application. The following paper will outline the findings and the planned approach for the FRIB helium refrigeration system.
Missaghi, Shahrzad; Young, Cara; Fegely, Kurt; Rajabi-Siahboomi, Ali R
2010-02-01
Formulation of proton pump inhibitors (PPIs) into oral solid dosage forms is challenging because the drug molecules are acid-labile. The aim of this study is to evaluate different formulation strategies (monolithic and multiparticulates) for three PPI drugs, that is, rabeprazole sodium, lansoprazole, and esomeprazole magnesium, using delayed release film coating applications. The core tablets of rabeprazole sodium were prepared using organic wet granulation method. Multiparticulates of lansoprazole and esomeprazole magnesium were prepared through drug layering of sugar spheres, using powder layering and suspension layering methods, respectively. Tablets and drug-layered multiparticulates were seal-coated, followed by delayed release film coating application, using Acryl-EZE(R), aqueous acrylic enteric system. Multiparticulates were then filled into capsules. The final dosage forms were evaluated for physical properties, as well as in vitro dissolution testing in both compendial acid phase, 0.1N HCl (pH 1.2), and intermediate pH, acetate buffer (pH 4.5), followed by phosphate buffer, pH 6.8. The stability of the delayed release dosage forms was evaluated upon storage in accelerated conditions [40 degrees C/75% relative humidity] for 3 months. All dosage forms demonstrated excellent enteric protection in the acid phase, followed by rapid release in their respective buffer media. Moreover, the delayed release dosage forms remained stable under accelerated stability conditions for 3 months. Results showed that Acryl-EZE enteric coating systems provide excellent performance in both media (0.1N HCl and acetate buffer pH 4.5) for monolithic and multiparticulate dosage forms.
The Comprehension of Rapid Speech by the Blind: Part III. Final Report.
ERIC Educational Resources Information Center
Foulke, Emerson
Accounts of completed and ongoing research conducted from 1964 to 1968 are presented on the subject of accelerated speech as a substitute for the written word. Included are a review of the research on intelligibility and comprehension of accelerated speech, some methods for controlling the word rate of recorded speech, and a comparison of…
Tic-Tac: Accelerating a Skateboard from Rest without Touching an External Support
ERIC Educational Resources Information Center
Kunesch, M.; Usunov, A.
2010-01-01
This paper outlines the solution that the Team of Austria found to problem number 7, "skateboarder", presented in the finals of the 22nd International Young Physicists' Tournament (IYPT) in Tianjin, China. We investigated how a skateboarder can accelerate from rest on a horizontal surface without touching an external support. The focus was laid on…
Reliability Considerations for the Operation of Large Accelerator User Facilities
Willeke, F. J.
2016-01-29
The lecture provides an overview of considerations relevant for achieving highly reliable operation of accelerator based user facilities. The article starts with an overview of statistical reliability formalism which is followed by high reliability design considerations with examples. Finally, the article closes with operational aspects of high reliability such as preventive maintenance and spares inventory.
Zuo, Pingbing; Zhang, Ming; Rassoul, Hamid K.
2013-10-03
The focused transport theory is appropriate to describe the injection and acceleration of low-energy particles at shocks as an extension of diffusive shock acceleration (DSA). In this investigation, we aim to characterize the role of cross-shock potential (CSP) originated in the charge separation across the shock ramp on pickup ion (PUI) acceleration at various types of shocks with a focused transport model. The simulation results of energy spectrum and spatial density distribution for the cases with and without CSP added in the model are compared. With sufficient acceleration time, the focused transport acceleration finally falls into the DSA regime withmore » the power-law spectral index equal to the solution of the DSA theory. The CSP can affect the shape of the spectrum segment at lower energies, but it does not change the spectral index of the final power-law spectrum at high energies. It is found that the CSP controls the injection efficiency which is the fraction of PUIs reaching the DSA regime. A stronger CSP jump results in a dramatically improved injection efficiency. Our simulation results also show that the injection efficiency of PUIs is mass-dependent, which is lower for species with a higher mass. Additionally, the CSP is able to enhance the particle reflection upstream to produce a stronger intensity spike at the shock front. Lastly, we conclude that the CSP is a non-negligible factor that affects the dynamics of PUIs at shocks.« less
Jackson, George S.; Hillegonds, Darren J.; Muzikar, Paul; Goehring, Brent
2013-01-01
A 41Ca interlaboratory comparison between Lawrence Livermore National Laboratory (LLNL) and the Purdue Rare Isotope Laboratory (PRIME Lab) has been completed. Analysis of the ratios assayed by accelerator mass spectrometry (AMS) shows that there is no statistically significant difference in the ratios. Further, Bayesian analysis shows that the uncertainties reported by both facilities are correct with the possibility of a slight under-estimation by one laboratory. Finally, the chemistry procedures used by the two facilities to produce CaF2 for the cesium sputter ion source are robust and don't yield any significant differences in the final result. PMID:24179312
Transfer of mechanical energy during the shot put.
Błażkiewicz, Michalina; Łysoń, Barbara; Chmielewski, Adam; Wit, Andrzej
2016-09-01
The aim of this study was to analyse transfer of mechanical energy between body segments during the glide shot put. A group of eight elite throwers from the Polish National Team was analysed in the study. Motion analysis of each throw was recorded using an optoelectronic Vicon system composed of nine infrared camcorders and Kistler force plates. The power and energy were computed for the phase of final acceleration of the glide shot put. The data were normalized with respect to time using the algorithm of the fifth order spline and their values were interpolated with respect to the percentage of total time, assuming that the time of the final weight acceleration movement was different for each putter. Statistically significant transfer was found in the study group between the following segments: Right Knee - Right Hip (p = 0.0035), Left Hip - Torso (p = 0.0201), Torso - Right Shoulder (p = 0.0122) and Right Elbow - Right Wrist (p = 0.0001). Furthermore, the results of cluster analysis showed that the kinetic chain used during the final shot acceleration movement had two different models. Differences between the groups were revealed mainly in the energy generated by the hips and trunk.
Implementation Guidance for Accelerated Bridge Construction in South Dakota : Research Brief
DOT National Transportation Integrated Search
2017-09-01
Investigate typical accelerated bridge construction methods and their applicability in South Dakota. A study was conducted to investigate the implementation of accelerated bridge construction (ABC) in South Dakota. The main objective of this study wa...
Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study.
Jo, Chris Hyunchul; Kim, Ji Eun; Yoon, Kang Sup; Lee, Ji Ho; Kang, Seung Baik; Lee, Jae Hyup; Han, Hyuk Soo; Rhee, Seung Hwan; Shin, Sue
2011-10-01
Platelet-rich plasma (PRP) has been recently used to enhance and accelerate the healing of musculoskeletal injuries and diseases, but evidence is still lacking, especially on its effects after rotator cuff repair. Platelet-rich plasma accelerates recovery after arthroscopic rotator cuff repair in pain relief, functional outcome, overall satisfaction, and enhanced structural integrity of repaired tendon. Cohort study; Level of evidence, 2. Forty-two patients with full-thickness rotator cuff tears were included. Patients were informed about the use of PRP before surgery and decided themselves whether to have PRP placed at the time of surgery. Nineteen patients underwent arthroscopic rotator cuff repair with PRP and 23 without. Platelet-rich plasma was prepared via plateletpheresis and applied in the form of a gel threaded to a suture and placed at the interface between tendon and bone. Outcomes were assessed preoperatively and at 3, 6, 12, and finally at a minimum of 16 months after surgery (at an average of 19.7 ± 1.9 months) with respect to pain, range of motion, strength, and overall satisfaction, and with respect to functional scores as determined using the following scoring systems: the American Shoulder and Elbow Surgeon (ASES) system, the Constant system, the University of California at Los Angeles (UCLA) system, the Disabilities of the Arm, Shoulder and Hand (DASH) system, the Simple Shoulder Test (SST) system, and the Shoulder Pain and Disability Index (SPADI) system. At a minimum of 9 months after surgery, repaired tendon structural integrities were assessed by magnetic resonance imaging. Platelet-rich plasma gel application to arthroscopic rotator cuff repairs did not accelerate recovery with respect to pain, range of motion, strength, functional scores, or overall satisfaction as compared with conventional repair at any time point. Whereas magnetic resonance imaging demonstrated a retear rate of 26.7% in the PRP group and 41.2% in the conventional group, there was no statistical significance between the groups (P = .388). The results suggest that PRP application during arthroscopic rotator cuff repair did not clearly demonstrate accelerated recovery clinically or anatomically except for an improvement in internal rotation. Nevertheless, as the study may have been underpowered to detect clinically important differences in the structural integrity, additional investigations, including the optimization of PRP preparation and a larger randomized study powered for healing rate, are necessary to further determine the effect of PRP.
Critical analysis of industrial electron accelerators
NASA Astrophysics Data System (ADS)
Korenev, S.
2004-09-01
The critical analysis of electron linacs for industrial applications (degradation of PTFE, curing of composites, modification of materials, sterlization and others) is considered in this report. Main physical requirements for industrial electron accelerators consist in the variations of beam parameters, such as kinetic energy and beam power. Questions for regulation of these beam parameters are considered. The level of absorbed dose in the irradiated product and throughput determines the main parameters of electron accelerator. The type of ideal electron linac for industrial applications is discussed.
Computing Models for FPGA-Based Accelerators
Herbordt, Martin C.; Gu, Yongfeng; VanCourt, Tom; Model, Josh; Sukhwani, Bharat; Chiu, Matt
2011-01-01
Field-programmable gate arrays are widely considered as accelerators for compute-intensive applications. A critical phase of FPGA application development is finding and mapping to the appropriate computing model. FPGA computing enables models with highly flexible fine-grained parallelism and associative operations such as broadcast and collective response. Several case studies demonstrate the effectiveness of using these computing models in developing FPGA applications for molecular modeling. PMID:21603152
High Power RF Testing of A 3-Cell Superconducting Traveling Wave Accelerating Structure
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kanareykin, Alex; Kostin, Romna; Avrakhov, Pavel
Euclid Techlabs has completed the Phase II SBIR project, entitled “High Power RF Testing of a 3-Cell Superconducting Traveling Wave Accelerating Structure” under Grant #DE-SC0006300. In this final technical report, we summarize the major achievements of Phase I of the project and review the details of Phase II of the project. The accelerating gradient in a superconducting structure is limited mainly by quenching, i.e., by the maximum surface RF magnetic field. Various techniques have been developed to increase the gradient. A traveling wave accelerating SC structure with a feedback waveguide was suggested to allow an increased transit time factor andmore » ultimately, a maximum gradient that is 22%-24% higher than in the best of the time standing wave SRF cavity solution. The proposed structure has an additional benefit in that it can be fabricated much longer than the standing wave ones that are limited by the field flatness factor. Taken together, all of these factors will result in a significant overall length and, correspondingly cost reduction of the SRF based linear collider ILC or SRF technology based FELs. In Phase I of this project, a 3-cell L-band SC traveling wave cavity was designed. Cavity shape, surface field ratios, inter-cell coupling coefficients, accelerating field flatness have been reviewed with the analysis of tuning issues. Moreover, the technological aspects of SC traveling wave accelerating structure fabrication have been studied. As the next step in the project, the Phase II experimental program included engineering design, manufacturing, surface processing and high gradient testing. Euclid Techlabs, LLC contracted AES, Inc. to manufacture two niobium cavities. Euclid Techlabs cold tested traveling wave regime in the cavity, and the results showed very good agreement with mathematical model specially developed for superconducting traveling wave cavity performance analysis. Traveling wave regime was adjusted by amplitude and phase variation of input signals due to application of developed power feeding scheme. Traveling wave excitation, adjustment and detection were successfully tested. Auxiliary equipment required for high power test such as the tuner, power and measure couplers, holding plates for VTS at Fermilab were developed and successfully tested. Both TW SRF cavities were fabricated by AES, Inc. without stiffening ribs before this company closed their production facility. Currently Roark EB welding company is finishing now welding process of the cavity for the high power testing at Fermilab VTS. Successful demonstration of high gradients in the 3-cell cavity along with studies of traveling wave excitation and tuning issues is leading to successful development of superconducting traveling wave technology for ILC applications and other future high energy SC accelerators.« less
NASA Astrophysics Data System (ADS)
Pasqua, Antonio; Chattopadhyay, Surajit; Khurshudyan, Martiros; Aly, Ayman A.
2014-09-01
In this paper, we studied the cosmological application of the interacting Ricci Dark Energy (RDE) model in the framework of the scalar Gauss-Bonnet modified gravity model. We studied the properties of the reconstructed potential , the Strong Energy Condition (SEC), the Weak Energy Condition (WEC) and the deceleration parameter q for three different models of scale factor, i.e. the emergent, the intermediate and the logamediate one. We obtained that , for the emergent scenario, has a decreasing behavior, while, for the logamediate scenario, the potential start with an increasing behavior then, for later times, it shows a slowly decreasing behavior. Finally, for the intermediate scenario, the potential has an initial increasing behavior, then for a time of t≈1.2, it starts to decrease. We also found that both SEC and WEC are violated for all the three scale factors considered. Finally, studying the plots of q, we derived that an accelerated universe can be achieved for the three models of scale factor considered.
Microelectromechanical acceleration-sensing apparatus
Lee, Robb M [Albuquerque, NM; Shul, Randy J [Albuquerque, NM; Polosky, Marc A [Albuquerque, NM; Hoke, Darren A [Albuquerque, NM; Vernon, George E [Rio Rancho, NM
2006-12-12
An acceleration-sensing apparatus is disclosed which includes a moveable shuttle (i.e. a suspended mass) and a latch for capturing and holding the shuttle when an acceleration event is sensed above a predetermined threshold level. The acceleration-sensing apparatus provides a switch closure upon sensing the acceleration event and remains latched in place thereafter. Examples of the acceleration-sensing apparatus are provided which are responsive to an acceleration component in a single direction (i.e. a single-sided device) or to two oppositely-directed acceleration components (i.e. a dual-sided device). A two-stage acceleration-sensing apparatus is also disclosed which can sense two acceleration events separated in time. The acceleration-sensing apparatus of the present invention has applications, for example, in an automotive airbag deployment system.
Marinetto, Eugenio; Victores, Juan González; García-Sevilla, Mónica; Muñoz, Mercedes; Calvo, Felipe Ángel; Balaguer, Carlos; Desco, Manuel; Pascau, Javier
2017-10-01
Intraoperative electron radiation therapy (IOERT) involves the delivery of a high radiation dose during tumor resection in a shorter time than other radiation techniques, thus improving local control of tumors. However, a linear accelerator device is needed to produce the beam safely. Mobile linear accelerators have been designed as dedicated units that can be moved into the operating room and deliver radiation in situ. Correct and safe dose delivery is a key concern when using mobile accelerators. The applicator is commonly fixed to the patient's bed to ensure that the dose is delivered to the prescribed location, and the mobile accelerator is moved to dock the applicator to the radiation beam output (gantry). In a typical clinical set-up, this task is time-consuming because of safety requirements and the limited degree of freedom of the gantry. The objective of this study was to present a navigation solution based on optical tracking for guidance of docking to improve safety and reduce procedure time. We used an optical tracker attached to the mobile linear accelerator to track the prescribed localization of the radiation collimator inside the operating room. Using this information, the integrated navigation system developed computes the movements that the mobile linear accelerator needs to perform to align the applicator and the radiation gantry and warns the physician if docking is unrealizable according to the available degrees of freedom of the mobile linear accelerator. Furthermore, we coded a software application that connects all the necessary functioning elements and provides a user interface for the system calibration and the docking guidance. The system could safeguard against the spatial limitations of the operating room, calculate the optimal arrangement of the accelerator and reduce the docking time in computer simulations and experimental setups. The system could be used to guide docking with any commercial linear accelerator. We believe that the docking navigator we present is a major contribution to IOERT, where docking is critical when attempting to reduce surgical time, ensure patient safety and guarantee that the treatment administered follows the radiation oncologist's prescription. © 2017 American Association of Physicists in Medicine.
NASA Astrophysics Data System (ADS)
Romaniuk, Ryszard S.
2013-10-01
Accelerator science and technology is one of a key enablers of the developments in the particle physic, photon physics and also applications in medicine and industry. The paper presents a digest of the research results in the domain of accelerator science and technology in Europe, shown during the realization of CARE (Coordinated Accelerator R&D), EuCARD (European Coordination of Accelerator R&D) and during the national annual review meeting of the TIARA - Test Infrastructure of European Research Area in Accelerator R&D. The European projects on accelerator technology started in 2003 with CARE. TIARA is an European Collaboration of Accelerator Technology, which by running research projects, technical, networks and infrastructural has a duty to integrate the research and technical communities and infrastructures in the global scale of Europe. The Collaboration gathers all research centers with large accelerator infrastructures. Other ones, like universities, are affiliated as associate members. TIARA-PP (preparatory phase) is an European infrastructural project run by this Consortium and realized inside EU-FP7. The paper presents a general overview of CARE, EuCARD and especially TIARA activities, with an introduction containing a portrait of contemporary accelerator technology and a digest of its applications in modern society. CARE, EuCARD and TIARA activities integrated the European accelerator community in a very effective way. These projects are expected very much to be continued.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Willert, Jeffrey; Taitano, William T.; Knoll, Dana
In this note we demonstrate that using Anderson Acceleration (AA) in place of a standard Picard iteration can not only increase the convergence rate but also make the iteration more robust for two transport applications. We also compare the convergence acceleration provided by AA to that provided by moment-based acceleration methods. Additionally, we demonstrate that those two acceleration methods can be used together in a nested fashion. We begin by describing the AA algorithm. At this point, we will describe two application problems, one from neutronics and one from plasma physics, on which we will apply AA. We provide computationalmore » results which highlight the benefits of using AA, namely that we can compute solutions using fewer function evaluations, larger time-steps, and achieve a more robust iteration.« less
Astrophysical particle acceleration mechanisms in colliding magnetized laser-produced plasmas
Fox, W.; Park, J.; Deng, W.; ...
2017-08-11
Significant particle energization is observed to occur in numerous astrophysical environments, and in the standard models, this acceleration occurs alongside energy conversion processes including collisionless shocks or magnetic reconnection. Recent platforms for laboratory experiments using magnetized laser-produced plasmas have opened opportunities to study these particle acceleration processes in the laboratory. Through fully kinetic particle-in-cell simulations, we investigate acceleration mechanisms in experiments with colliding magnetized laser-produced plasmas, with geometry and parameters matched to recent high-Mach number reconnection experiments with externally controlled magnetic fields. 2-D simulations demonstrate significant particle acceleration with three phases of energization: first, a “direct” Fermi acceleration driven bymore » approaching magnetized plumes; second, x-line acceleration during magnetic reconnection of anti-parallel fields; and finally, an additional Fermi energization of particles trapped in contracting and relaxing magnetic islands produced by reconnection. Furthermore, the relative effectiveness of these mechanisms depends on plasma and magnetic field parameters of the experiments.« less
ERIC Educational Resources Information Center
Rosenblatt, Rebecca; Heckler, Andrew F.
2011-01-01
We developed an instrument to systematically investigate student conceptual understanding of the relationships between the directions of net force, velocity, and acceleration in one dimension and report on data collected on the final version of the instrument from over 650 students. Unlike previous work, we simultaneously studied all six possible…
First muon acceleration using a radio-frequency accelerator
NASA Astrophysics Data System (ADS)
Bae, S.; Choi, H.; Choi, S.; Fukao, Y.; Futatsukawa, K.; Hasegawa, K.; Iijima, T.; Iinuma, H.; Ishida, K.; Kawamura, N.; Kim, B.; Kitamura, R.; Ko, H. S.; Kondo, Y.; Li, S.; Mibe, T.; Miyake, Y.; Morishita, T.; Nakazawa, Y.; Otani, M.; Razuvaev, G. P.; Saito, N.; Shimomura, K.; Sue, Y.; Won, E.; Yamazaki, T.
2018-05-01
Muons have been accelerated by using a radio-frequency accelerator for the first time. Negative muonium atoms (Mu- ), which are bound states of positive muons (μ+) and two electrons, are generated from μ+'s through the electron capture process in an aluminum degrader. The generated Mu- 's are initially electrostatically accelerated and injected into a radio-frequency quadrupole linac (RFQ). In the RFQ, the Mu- 's are accelerated to 89 keV. The accelerated Mu- 's are identified by momentum measurement and time of flight. This compact muon linac opens the door to various muon accelerator applications including particle physics measurements and the construction of a transmission muon microscope.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Chng, Brenda; Mann, Robert; Department of Physics, University of Waterloo 200 University Avenue West, Waterloo, Ontario N2L 3G1
We construct new solutions of the vacuum Einstein field equations in four dimensions via a solution-generating method utilizing the SL(2,R) symmetry of the reduced Lagrangian. We apply the method to an accelerating version of the Zipoy-Voorhees solution and generate new solutions which we interpret to be the accelerating versions of the Zipoy-Voorhees generalization of the Taub-NUT solution (with Lorentzian signature) and the Zipoy-Voorhees generalization of the Eguchi-Hanson solitons (with Euclidean signature). As an intermediary in the solution-generating process we obtain charged versions of the accelerated Zipoy-Voorhees-like families of solutions. Finally we present the accelerating version of the Taub-NUT solution andmore » discuss its properties.« less
Acceleration environment of payloads while being handled by the Shuttle Remote Manipulator System
NASA Technical Reports Server (NTRS)
Turnbull, J. F.
1983-01-01
Described in this paper is the method used in the Draper Remote Manipulator System (RMS) Simulation to compute linear accelerations at the point on the SPAS01 payload where its accelerometers are mounted. Simulated accelerometer output for representative on-orbit activities is presented. The objectives of post-flight analysis of SPAS01 data are discussed. Finally, the point is made that designers of acceleration-dependent payloads may have an interest in the capability of simulating the acceleration environment of payloads while under the control of the overall Payload Deployment and retrieval System (PDRS) that includes the Orbiter and its attitude control system as well as the Remote Manipulator Arm.
Electron beam irradiation processing for industrial and medical applications
NASA Astrophysics Data System (ADS)
Ozer, Zehra Nur
2017-09-01
In recent years, electron beam processing has been widely used for medical and industrial applications. Electron beam accelerators are reliable and durable equipments that can produce ionizing radiation when it is needed for a particular commercial use. On the industrial scale, accelerators are used to generate electrons in between 0.1-100 MeV energy range. These accelerators are used mainly in plastics, automotive, wire and electric cables, semiconductors, health care, aerospace and environmental industries, as well as numerous researches. This study presents the current applications of electron beam processing in medicine and industry. Also planned study of a design for such a system in the energy range of 200-300 keV is introduced.
NASA Astrophysics Data System (ADS)
Alvanos, Michail; Christoudias, Theodoros
2017-10-01
This paper presents an application of GPU accelerators in Earth system modeling. We focus on atmospheric chemical kinetics, one of the most computationally intensive tasks in climate-chemistry model simulations. We developed a software package that automatically generates CUDA kernels to numerically integrate atmospheric chemical kinetics in the global climate model ECHAM/MESSy Atmospheric Chemistry (EMAC), used to study climate change and air quality scenarios. A source-to-source compiler outputs a CUDA-compatible kernel by parsing the FORTRAN code generated by the Kinetic PreProcessor (KPP) general analysis tool. All Rosenbrock methods that are available in the KPP numerical library are supported.Performance evaluation, using Fermi and Pascal CUDA-enabled GPU accelerators, shows achieved speed-ups of 4. 5 × and 20. 4 × , respectively, of the kernel execution time. A node-to-node real-world production performance comparison shows a 1. 75 × speed-up over the non-accelerated application using the KPP three-stage Rosenbrock solver. We provide a detailed description of the code optimizations used to improve the performance including memory optimizations, control code simplification, and reduction of idle time. The accuracy and correctness of the accelerated implementation are evaluated by comparing to the CPU-only code of the application. The median relative difference is found to be less than 0.000000001 % when comparing the output of the accelerated kernel the CPU-only code.The approach followed, including the computational workload division, and the developed GPU solver code can potentially be used as the basis for hardware acceleration of numerous geoscientific models that rely on KPP for atmospheric chemical kinetics applications.
Park, Daejin; Cho, Jeonghun
2014-01-01
A specially designed sensor processor used as a main processor in IoT (internet-of-thing) device for the rare-event sensing applications is proposed. The IoT device including the proposed sensor processor performs the event-driven sensor data processing based on an accuracy-energy configurable event-quantization in architectural level. The received sensor signal is converted into a sequence of atomic events, which is extracted by the signal-to-atomic-event generator (AEG). Using an event signal processing unit (EPU) as an accelerator, the extracted atomic events are analyzed to build the final event. Instead of the sampled raw data transmission via internet, the proposed method delays the communication with a host system until a semantic pattern of the signal is identified as a final event. The proposed processor is implemented on a single chip, which is tightly coupled in bus connection level with a microcontroller using a 0.18 μm CMOS embedded-flash process. For experimental results, we evaluated the proposed sensor processor by using an IR- (infrared radio-) based signal reflection and sensor signal acquisition system. We successfully demonstrated that the expected power consumption is in the range of 20% to 50% compared to the result of the basement in case of allowing 10% accuracy error.
Beam manipulation with velocity bunching for PWFA applications
NASA Astrophysics Data System (ADS)
Pompili, R.; Anania, M. P.; Bellaveglia, M.; Biagioni, A.; Bisesto, F.; Chiadroni, E.; Cianchi, A.; Croia, M.; Curcio, A.; Di Giovenale, D.; Ferrario, M.; Filippi, F.; Galletti, M.; Gallo, A.; Giribono, A.; Li, W.; Marocchino, A.; Mostacci, A.; Petrarca, M.; Petrillo, V.; Di Pirro, G.; Romeo, S.; Rossi, A. R.; Scifo, J.; Shpakov, V.; Vaccarezza, C.; Villa, F.; Zhu, J.
2016-09-01
The activity of the SPARC_LAB test-facility (LNF-INFN, Frascati) is currently focused on the development of new plasma-based accelerators. Particle accelerators are used in many fields of science, with applications ranging from particle physics research to advanced radiation sources (e.g. FEL). The demand to accelerate particles to higher and higher energies is currently limited by the effective efficiency in the acceleration process that requires the development of km-size facilities. By increasing the accelerating gradient, the compactness can be improved and costs reduced. Recently, the new technique which attracts main efforts relies on plasma acceleration. In the following, the current status of plasma-based activities at SPARC_LAB is presented. Both laser- and beam-driven schemes will be adopted with the aim to provide an adequate accelerating gradient (1-10 GV/m) while preserving the brightness of the accelerated beams to the level of conventional photo-injectors. This aspect, in particular, requires the use of ultra-short (< 100 fs) electron beams, consisting in one or more bunches. We show, with the support of simulations and experimental results, that such beams can be produced using RF compression by velocity-bunching.
NASA Astrophysics Data System (ADS)
Chang, Tsui-Yu; Cotton, Fabrice; Angelier, Jacques; Shin, Tzay-Chyn
2001-07-01
Attenuation laws are widely used in order to estimate the peak ground acceleration that may occur at a given locality during an earthquake, for hazard evaluation purposes. However, these simplified laws should be regarded acceptable only in the first approximation, because numerous significant parameters at the local and regional scales are often ignored. We examined the relationship between distance and peak acceleration based on examples from the dense accelerometric network of Taiwan, specifically for the Chichi destructive earthquake. We thus observed significant discrepancies between the predicted and observed accelerations, resulting from (1) near-field saturation, (2) amplification in sedimentary basins, and (3) hanging wall effect. We mapped the residual accelerations (difference between observed and predicted peak ground accelerations). This highlights the role of the regional structure, independently revealed by the geological analysis, as a significant factor that controls the transmission of the seismic accelerations.
High Energy Density Physics and Exotic Acceleration Schemes
DOE Office of Scientific and Technical Information (OSTI.GOV)
Cowan, T.; /General Atomics, San Diego; Colby, E.
2005-09-27
The High Energy Density and Exotic Acceleration working group took as our goal to reach beyond the community of plasma accelerator research with its applications to high energy physics, to promote exchange with other disciplines which are challenged by related and demanding beam physics issues. The scope of the group was to cover particle acceleration and beam transport that, unlike other groups at AAC, are not mediated by plasmas or by electromagnetic structures. At this Workshop, we saw an impressive advancement from years past in the area of Vacuum Acceleration, for example with the LEAP experiment at Stanford. And wemore » saw an influx of exciting new beam physics topics involving particle propagation inside of solid-density plasmas or at extremely high charge density, particularly in the areas of laser acceleration of ions, and extreme beams for fusion energy research, including Heavy-ion Inertial Fusion beam physics. One example of the importance and extreme nature of beam physics in HED research is the requirement in the Fast Ignitor scheme of inertial fusion to heat a compressed DT fusion pellet to keV temperatures by injection of laser-driven electron or ion beams of giga-Amp current. Even in modest experiments presently being performed on the laser-acceleration of ions from solids, mega-amp currents of MeV electrons must be transported through solid foils, requiring almost complete return current neutralization, and giving rise to a wide variety of beam-plasma instabilities. As keynote talks our group promoted Ion Acceleration (plenary talk by A. MacKinnon), which historically has grown out of inertial fusion research, and HIF Accelerator Research (invited talk by A. Friedman), which will require impressive advancements in space-charge-limited ion beam physics and in understanding the generation and transport of neutralized ion beams. A unifying aspect of High Energy Density applications was the physics of particle beams inside of solids, which is proving to be a very important field for diverse applications such as muon cooling, fusion energy research, and ultra-bright particle and radiation generation with high intensity lasers. We had several talks on these and other subjects, and many joint sessions with the Computational group, the EM Structures group, and the Beam Generation group. We summarize our groups' work in the following categories: vacuum acceleration schemes; ion acceleration; particle transport in solids; and applications to high energy density phenomena.« less
Development of a wireless displacement measurement system using acceleration responses.
Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F
2013-07-01
Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system.
Development of a Wireless Displacement Measurement System Using Acceleration Responses
Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F.
2013-01-01
Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system. PMID:23881123
Laschinsky, Lydia; Baumann, Michael; Beyreuther, Elke; Enghardt, Wolfgang; Kaluza, Malte; Karsch, Leonhard; Lessmann, Elisabeth; Naumburger, Doreen; Nicolai, Maria; Richter, Christian; Sauerbrey, Roland; Schlenvoigt, Hans-Peter; Pawelke, Jörg
2012-01-01
The notable progress in laser particle acceleration technology promises potential medical application in cancer therapy through compact and cost effective laser devices that are suitable for already existing clinics. Previously, consequences on the radiobiological response by laser driven particle beams characterised by an ultra high peak dose rate have to be investigated. Therefore, tumour and non-malignant cells were irradiated with pulsed laser accelerated electrons at the JETI facility for the comparison with continuous electrons of a conventional therapy LINAC. Dose response curves were measured for the biological endpoints clonogenic survival and residual DNA double strand breaks. The overall results show no significant differences in radiobiological response for in vitro cell experiments between laser accelerated pulsed and clinical used electron beams. These first systematic in vitro cell response studies with precise dosimetry to laser driven electron beams represent a first step toward the long term aim of the application of laser accelerated particles in radiotherapy.
Development of the negative ion beams relevant to ITER and JT-60SA at Japan Atomic Energy Agency.
Hanada, M; Kojima, A; Tobari, H; Nishikiori, R; Hiratsuka, J; Kashiwagi, M; Umeda, N; Yoshida, M; Ichikawa, M; Watanabe, K; Yamano, Y; Grisham, L R
2016-02-01
In order to realize negative ion sources and accelerators to be applicable to International Thermonuclear Experimental Reactor and JT-60 Super Advanced, a large cesium (Cs)-seeded negative ion source and a multi-aperture and multi-stage electric acceleration have been developed at Japan Atomic Energy Agency (JAEA). Long pulse production and acceleration of the negative ion beams have been independently carried out. The long pulse production of the high current beams has achieved 100 s at the beam current of 15 A by modifying the JT-60 negative ion source. The pulse duration time is increased three times longer than that before the modification. As for the acceleration, a pulse duration time has been also extended two orders of magnitudes from 0.4 s to 60 s. The developments of the negative ion source and acceleration at JAEA are well in progress towards the realization of the negative ion sources and accelerators for fusion applications.
Mechanical suppression: Modern technology applied to an old art. [MK 12 motors
NASA Technical Reports Server (NTRS)
Crockford, W. H.; Durney, T. E.; Scott, D. E.; Condon, J. A.
1980-01-01
Various suppressor configurations were analyzed and evaluated in an effort to reduce combustion instability and improved ballistic reproducibility of the MK 12 motor. A static firing test series of eight field return boosters featured two baseline motor firings with the existing suppressor in each motor, followed by two tests each of two different prototype suppressor designs. Results were analyzed and used to generate the design for the final two firings. Acoustic pressure pulsers were utilized to measure the damping effectiveness of the final design. The reduction in motor vibration and acoustic pressure levels between the baseline tests and the final two improved lightweight tests was significant. The average acceleration level of the motors equipped with flightweight rods was reduced to only 5% of the level in the unmodified motors; the average acoustic pressure level was reduced to 20%; maximum values were reduced to 6% for acceleration and 23% for pressure.
NASA Technical Reports Server (NTRS)
Hodges, G. E.; Mcgehee, C. R.
1981-01-01
The final design and hardware fabrication was completed for an active control system capable of the required flutter suppression, compatible with and ready for installation in the NASA aeroelastic research wing number 1 (ARW-1) on Firebee II drone flight test vehicle. The flutter suppression system uses vertical acceleration at win buttock line 1.930 (76), with fuselage vertical and roll accelerations subtracted out, to drive wing outboard aileron control surfaces through appropriate symmetric and antisymmetric shaping filters. The goal of providing an increase of 20 percent above the unaugmented vehicle flutter velocity but below the maximum operating condition at Mach 0.98 is exceeded by the final flutter suppression system. Results indicate that the flutter suppression system mechanical and electronic components are ready for installation on the DAST ARW-1 wing and BQM-34E/F drone fuselage.
Betatron Application in Mobile and Relocatable Inspection Systems for Freight Transport Control
NASA Astrophysics Data System (ADS)
Chakhlov, S. V.; Kasyanov, S. V.; Kasyanov, V. A.; Osipov, S. P.; Stein, M. M.; Stein, A. M.; Xiaoming, Sun
2016-01-01
Accelerators with energy level up to 4 MeV having high level of penetration ability by steel equivalent are the popular to control oversize cargo transported by road, by railway and by river. Betatron's usage as cyclic induction accelerator has some advantages in comparison with linear accelerators and other sources. Tomsk Polytechnic University has developed many types of betatrons, most of them are being produced by separate affiliated company " Foton ". Article is shown the results of application of the betatrons in inspection custom systems.
Heating and acceleration of escaping planetary ions
NASA Astrophysics Data System (ADS)
Nilsson, Hans
2010-05-01
The magnetic field of the Earth acts like a shield against the solar wind, leading to a magnetopause position many planetary radii away from the planet, in contrast to the situation at non- or weakly magnetized planets such as Mars and Venus. Despite this there is significant ion outflow due to solar wind interaction from the cusp and polar cap regions of the Earth's ionosphere. Effective interaction regions form, in particular in the ionospheric projection of the cusp, where ionospheric plasma flows up along the field-lines in response to magnetospheric energy input. Strong wave-particle interaction at altitudes above the ionosphere further accelerates the particles so that gravity is overcome. For the particles to enter a direct escape path they must be accelerated along open magnetic field lines so that they cross the magnetopause or reach a distance beyond the region of return flow in the tail. This return flow may also be either lost to space or returned to the atmosphere. Throughout this transport chain the heating and acceleration experienced by the particles will have an influence on the final fate of the particles. We will present quantitative estimates of centrifugal acceleration and perpendicular heating along the escape path from the cusp, through the high altitude polar cap/mantle, based on Cluster spacecraft data. We will open up for a discussion on the benefits of a ponderomotive force description of the acceleration affecting the ion circulation and escape. Finally we will compare with the situation at the unmagnetized planets Mars and Venus and discuss to what extent a magnetic field protects an atmosphere from loss through solar wind interaction.
Analysis of Cultural Heritage by Accelerator Techniques and Analytical Imaging
NASA Astrophysics Data System (ADS)
Ide-Ektessabi, Ari; Toque, Jay Arre; Murayama, Yusuke
2011-12-01
In this paper we present the result of experimental investigation using two very important accelerator techniques: (1) synchrotron radiation XRF and XAFS; and (2) accelerator mass spectrometry and multispectral analytical imaging for the investigation of cultural heritage. We also want to introduce a complementary approach to the investigation of artworks which is noninvasive and nondestructive that can be applied in situ. Four major projects will be discussed to illustrate the potential applications of these accelerator and analytical imaging techniques: (1) investigation of Mongolian Textile (Genghis Khan and Kublai Khan Period) using XRF, AMS and electron microscopy; (2) XRF studies of pigments collected from Korean Buddhist paintings; (3) creating a database of elemental composition and spectral reflectance of more than 1000 Japanese pigments which have been used for traditional Japanese paintings; and (4) visible light-near infrared spectroscopy and multispectral imaging of degraded malachite and azurite. The XRF measurements of the Japanese and Korean pigments could be used to complement the results of pigment identification by analytical imaging through spectral reflectance reconstruction. On the other hand, analysis of the Mongolian textiles revealed that they were produced between 12th and 13th century. Elemental analysis of the samples showed that they contained traces of gold, copper, iron and titanium. Based on the age and trace elements in the samples, it was concluded that the textiles were produced during the height of power of the Mongol empire, which makes them a valuable cultural heritage. Finally, the analysis of the degraded and discolored malachite and azurite demonstrates how multispectral analytical imaging could be used to complement the results of high energy-based techniques.
Accelerated corneal crosslinking concurrent with laser in situ keratomileusis.
Celik, H Ugur; Alagöz, Nese; Yildirim, Yusuf; Agca, Alper; Marshall, John; Demirok, Ahmet; Yilmaz, Omer Faruk
2012-08-01
To assess accelerated corneal collagen crosslinking (CXL) applied concurrently with laser in situ keratomileusis (LASIK) in a small group of patients. Beyoglu Eye Research and Training Hospital, Istanbul, Turkey. Prospective pilot interventional case series. In May 2010, patients had LASIK with concurrent accelerated CXL in 1 eye and LASIK only in the fellow eye to treat myopia or myopic astigmatism. The follow-up was 12 months. The attempted correction (spherical equivalent) ranged from -5.00 to -8.50 diopters (D) in the LASIK-CXL group and from -3.00 to -7.25 D in the LASIK-only group. Main outcome measures were manifest refraction, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, and the endothelial cell count. Eight eyes of 3 women and 1 man (age 22 to 39 years old) were enrolled. At the 12-month follow-up, the LASIK-CXL group had a UDVA and manifest refraction equal to or better than those in the LASIK-only group. No eye lost 1 or more lines of CDVA at the final visit. The endothelial cell loss in the LASIK-CXL eye was not greater than in the fellow eye. No side effects were associated with either procedure. Laser in situ keratomileusis with accelerated CXL appears to be a promising modality for future applications to prevent corneal ectasia after LASIK treatment. The results in this pilot series suggest that evaluation of a larger study cohort is warranted. Drs. Yilmaz and Marshall are paid consultants to Avedro, Inc. No other author has a financial or proprietary interest in any material or method mentioned. Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Free-electron laser emission architecture impact on extreme ultraviolet lithography
NASA Astrophysics Data System (ADS)
Hosler, Erik R.; Wood, Obert R.; Barletta, William A.
2017-10-01
Laser-produced plasma (LPP) EUV sources have demonstrated ˜125 W at customer sites, establishing confidence in EUV lithography (EUVL) as a viable manufacturing technology. However, for extension to the 3-nm technology node and beyond, existing scanner/source technology must enable higher-NA imaging systems (requiring increased resist dose and providing half-field exposures) and/or EUV multipatterning (requiring increased wafer throughput proportional to the number of exposure passes). Both development paths will require a substantial increase in EUV source power to maintain the economic viability of the technology, creating an opportunity for free-electron laser (FEL) EUV sources. FEL-based EUV sources offer an economic, high-power/single-source alternative to LPP EUV sources. Should FELs become the preferred next-generation EUV source, the choice of FEL emission architecture will greatly affect its operational stability and overall capability. A near-term industrialized FEL is expected to utilize one of the following three existing emission architectures: (1) self-amplified spontaneous emission, (2) regenerative amplifier, or (3) self-seeding. Model accelerator parameters are put forward to evaluate the impact of emission architecture on FEL output. Then, variations in the parameter space are applied to assess the potential impact to lithography operations, thereby establishing component sensitivity. The operating range of various accelerator components is discussed based on current accelerator performance demonstrated at various scientific user facilities. Finally, comparison of the performance between the model accelerator parameters and the variation in parameter space provides a means to evaluate the potential emission architectures. A scorecard is presented to facilitate this evaluation and provides a framework for future FEL design and enablement for EUVL applications.
Basilio, Numa; Morice, Antoine H P; Marti, Geoffrey; Montagne, Gilles
2015-08-01
The aim of this study was to answer the question, Do drivers take into account the action boundaries of their car when overtaking? The Morice et al. affordance-based approach to visually guided overtaking suggests that the "overtake-ability" affordance can be formalized as the ratio of the "minimum satisfying velocity" (MSV) of the maneuver to the maximum velocity (V(max)) of the driven car. In this definition, however, the maximum acceleration (A(max)) of the vehicle is ignored. We hypothesize that drivers may be sensitive to an affordance redefined with the ratio of the "minimum satisfying acceleration" (MSA) to the A(max) of the car. Two groups of nine drivers drove cars differing in their A(max). They were instructed to attempt overtaking maneuvers in 25 situations resulting from the combination of five MSA and five MSV values. When overtaking frequency was expressed as a function of MSV and MSA, maneuvers were found to be initiated differently for the two groups. However, when expressed as a function of MSV/V(max) and MSA/A(max), overtaking frequency was quite similar for both groups. Finally, a multiple regression coefficient analysis demonstrated that overtaking decisions are fully explained by a composite variable comprising MSA/A(max) and the time required to reach MSV. Drivers reliably decide whether overtaking is safe (or not) by using low- and high-order variables taking into account their car's maximum velocity and acceleration, respectively, as predicted by "affordance-based control" theory. Potential applications include the design of overtaking assistance, which should exploit the MSA/A(max) variables in order to suggest perceptually relevant overtaking solutions. © 2015, Human Factors and Ergonomics Society.
Torres, Susana; Brown, Roland; Szucs, Roman; Hawkins, Joel M; Zelesky, Todd; Scrivens, Garry; Pettman, Alan; Taylor, Mark R
2015-11-10
The aim of this study was to evaluate the use of electrochemistry to generate oxidative degradation products of a model pharmaceutical compound. The compound was oxidized at different potentials using an electrochemical flow-cell fitted with a glassy carbon working electrode, a Pd/H2 reference electrode and a titanium auxiliary electrode. The oxidative products formed were identified and structurally characterized by LC-ESI-MS/MS using a high resolution Q-TOF mass spectrometer. Results from electrochemical oxidation using electrolytes of different pH were compared to those from chemical oxidation and from accelerated stability studies. Additionally, oxidative degradation products predicted using an in silico commercially available software were compared to those obtained from the various experimental methods. The electrochemical approach proved to be useful as an oxidative stress test as all of the final oxidation products observed under accelerated stability studies could be generated; previously reported reactive intermediate species were not observed most likely because the electrochemical mechanism differs from the oxidative pathway followed under accelerated stability conditions. In comparison to chemical degradation tests electrochemical degradation has the advantage of being much faster and does not require the use of strong oxidizing agents. Moreover, it enables the study of different operating parameters in short periods of time and optimisation of the reaction conditions (pH and applied potential) to achieve different oxidative products mixtures. This technique may prove useful as a stress test condition for the generation of oxidative degradation products and may help accelerate structure elucidation and development of stability indicating analytical methods. Copyright © 2015 Elsevier B.V. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kanninen, M.F.; O'Donoghue, P.E.; Popelar, C.F.
1993-02-01
The project was undertaken for the purposes of quantifying the Battelle slow crack growth (SCG) test for predicting long-term performance of polyethylene gas distribution pipes, and of demonstrating the applicability of the methodology for use by the gas industry for accelerated characterization testing, thereby bringing the SCG test development effort to a closure. The work has revealed that the Battelle SCG test, and the linear fracture mechanics interpretation that it currently utilizes, is valid for a class of PE materials. The long-term performance of these materials in various operating conditions can therefore be effectively predicted.
Patent prosecution strategies for stem cell related applications.
Kumar, Rajeev; Yeh, Jenny J; Fernandez, Dennis; Hansen, Nels
2007-09-01
Stem cell research and the intellectual property derived from it, because of its potential to completely transform health care, demand an especially high level of consideration from business and patent prosecution perspectives. As with other revolutionary technologies, ordinary risks are amplified (e.g., litigation), and ordinarily irrelevant considerations may become important (e.g., heightened level of both domestic and foreign legislative risk). In the first part of this article, general strategies for patent prosecutors such as several prosecution considerations and methods for accelerating patent prosecution process are presented. In the second part, patent prosecution challenges of stem cell-related patents and possible solutions are discussed. In the final part, ethical and public policy issues particular to stem cell-related and other biotechnological inventions are summarized.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Geveci, Berk; Maynard, Robert
The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. The XVis project brought together collaborators from predominant DOE projects for visualization on accelerators and combining their respectivemore » features into a new visualization toolkit called VTK-m.« less
Modal control of an unstable periodic orbit
NASA Astrophysics Data System (ADS)
Wiesel, W.; Shelton, W.
1983-03-01
Floquet theory is applied to the problem of designing a control system for a satellite in an unstable periodic orbit. Expansion about a periodic orbit produces a time-periodic linear system, which is augmented by a time-periodic control term. It is shown that this can be done such that (1) the application of control produces only inertial accelerations, (2) positive real Poincareexponents are shifted into the left half-plane, and (3) the shift of the exponent is linear with control gain. These developments are applied to an unstable orbit near the earth-moon L(3) point pertubed by the sun. Finally, it is shown that the control theory can be extended to include first order perturbations about the periodic orbit without increase in control cost.
Modal control of an unstable periodic orbit
NASA Technical Reports Server (NTRS)
Wiesel, W.; Shelton, W.
1983-01-01
Floquet theory is applied to the problem of designing a control system for a satellite in an unstable periodic orbit. Expansion about a periodic orbit produces a time-periodic linear system, which is augmented by a time-periodic control term. It is shown that this can be done such that (1) the application of control produces only inertial accelerations, (2) positive real Poincareexponents are shifted into the left half-plane, and (3) the shift of the exponent is linear with control gain. These developments are applied to an unstable orbit near the earth-moon L(3) point pertubed by the sun. Finally, it is shown that the control theory can be extended to include first order perturbations about the periodic orbit without increase in control cost.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Huang, Zhirong; Hogan, Mark
Essentially all we know today and will learn in the future about the fundamental nature of matter is derived from probing it with directed beams of particles such as electrons, protons, neutrons, heavy ions, and photons. The resulting ability to “see” the building blocks of matter has had an immense impact on society and our standard of living. Over the last century, particle accelerators have changed the way we look at nature and the universe we live in and have become an integral part of the Nation’s technical infrastructure. Today, particle accelerators are essential tools of modern science and technology.more » The cost and capabilities of accelerators would be greatly enhanced by breakthroughs in acceleration methods and technology. For the last 32 years, the Advanced Accelerator Concepts (AAC) Workshop has acted as the focal point for discussion and development of the most promising acceleration physics and technology. It is a particularly effective forum where the discussion is leveraged and promoted by the unique and demanding feature of the AAC Workshop: the working group structure, in which participants are asked to consider their contributions in terms of even larger problems to be solved. The 16th Advanced Accelerator Concepts (AAC2014) Workshop was organized by Stanford University from July 13 - 18, 2014 at the Dolce Hays Mansion in San Jose, California. The conference had a record 282 attendees including 62 students. Attendees came from 11 countries representing 66 different institutions. The workshop format consisted of plenary sessions in the morning with topical leaders from around the world presenting the latest breakthroughs to the entire workshop. In the late morning and afternoons attendees broke out into eight different working groups for more detailed presentations and discussions that were summarized on the final day of the workshop. In addition, there were student tutorial presentations on two afternoons to provide in depth education and training for the next generation of accelerator scientists. This is the final technical report on the organization and outcome of AAC2014.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Piekarz, Henryk; Hays, Steven; /Fermilab
We propose to build the DSF-MR (Double Super-Ferric Main Ring), 480 GeV, fast-cycling (2 second repetition rate) two-beam proton accelerator in the Main Ring tunnel of Fermilab. This accelerator design is based on the super-ferric magnet technology developed for the VLHC, and extended recently to the proposed LER injector for the LHC and fast cycling SF-SPS at CERN. The DSF-MR accelerator system will constitute the final stage of the proton source enabling production of two neutrino beams separated by 2 second time period. These beams will be sent alternately to two detectors located at {approx} 3000 km and {approx} 7500more » km away from Fermilab. It is expected that combination of the results from these experiments will offer more than 3 order of magnitudes increased sensitivity for detection and measurement of neutrino oscillations with respect to expectations in any current experiment, and thus may truly enable opening the window into the physics beyond the Standard Model. We examine potential sites for the long baseline neutrino detectors accepting beams from Fermilab. The current injection system consisting of 400 MeV Linac, 8 GeV Booster and the Main Injector can be used to accelerate protons to 45 GeV before transferring them to the DSF-MR. The implementation of the DSF-MR will allow for an 8-fold increase in beam power on the neutrino production target. In this note we outline the proposed new arrangement of the Fermilab accelerator complex. We also briefly describe the DSF-MR magnet design and its power supply, and discuss necessary upgrade of the Tevatron RF system for the use with the DSF-MR accelerator. Finally, we outline the required R&D, cost estimate and possible timeline for the implementation of the DSF-MR accelerator.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Stariha, Sarah; Macauley, Natalia; Sneed, Brian T.
The U.S. Department of Energy (DOE) set the 2020 durability target for polymer electrolyte membrane fuel cell transportation applications at 5000 hours. Since it is impractical to test every fuel cell for this length of time, there is ever increasing interest in developing accelerated stress tests (ASTs) that can accurately simulate the material component degradation in the membrane electrode assembly (MEA) observed under automotive operating conditions, but over a much shorter time frame. In this study, a square-wave catalyst AST was examined that shows a 5X time acceleration factor over the triangle-wave catalyst AST and a 25X time acceleration factormore » over the modified wet drive-cycle catalyst durability protocol, significantly decreasing the testing time. These acceleration factors were correlated to the platinum (Pt) particle size increase and associated decrease in electrochemical surface area (ECSA). This square-wave AST has been adopted by the DOE as a standard protocol to evaluate catalyst durability. We also compare three catalyst-durability protocols using state-of-the-art platinum-cobalt catalysts supported on high surface area carbon (SOA Pt-Co/HSAC) in the cathode catalyst layer. The results for each of the three tests showed both catalyst particle size increase and transition metal leaching. Moreover the acceleration factors for the alloy catalysts were smaller due to Co leaching being the predominant mechanism of voltage decay in ~5 nm PtCo/C catalysts. Finally, an extremely harsh carbon corrosion AST was run using the same SOA Pt-Co/HSAC catalyst. This showed minimal change in particle size and a low percentage Co loss from the cathode catalyst particles, despite a significant loss in catalyst layer thickness and cell performance. The carbon corrosion rates during these various ASTs were directly measured by monitoring the CO 2 emission from the cathode, further confirming the ability of the square-wave AST to evaluate the electro-catalyst independently of the support.« less
Wireless sensor node for detection of freight train derailment
NASA Astrophysics Data System (ADS)
Costa, Andrea; Milani, Damiano; Resta, Ferruccio; Tomasini, Gisella
2016-04-01
The target of the research activity presented in this paper is to design, to realize and to test an autonomous sensor node able to measure the accelerations in correspondence of the axle box of a freight train. The final goal of the sensor is to identify the derailment conditions by observing the variations in the spectra of the box accelerations, around the frequencies associated to the wheel revolution and its multiples. The sensor node embeds an accelerometer, a microprocessor, a transmission system, a piezoelectric bimorph energy harvester and an integrated circuit for managing the power distribution to each component of the node. In particular, a mechanical filter to be applied to the node was specifically designed to increment the energy recovered by the harvester and to filter out the high frequency components of the axle-box acceleration, allowing the use of a more sensitive accelerometer. The harvesting system was setup by means of laboratory tests carried out with an electromechanical shaker and the sensor node was finally tested through field tests on freight trains.
An Embedded Sensor Node Microcontroller with Crypto-Processors.
Panić, Goran; Stecklina, Oliver; Stamenković, Zoran
2016-04-27
Wireless sensor network applications range from industrial automation and control, agricultural and environmental protection, to surveillance and medicine. In most applications, data are highly sensitive and must be protected from any type of attack and abuse. Security challenges in wireless sensor networks are mainly defined by the power and computing resources of sensor devices, memory size, quality of radio channels and susceptibility to physical capture. In this article, an embedded sensor node microcontroller designed to support sensor network applications with severe security demands is presented. It features a low power 16-bitprocessor core supported by a number of hardware accelerators designed to perform complex operations required by advanced crypto algorithms. The microcontroller integrates an embedded Flash and an 8-channel 12-bit analog-to-digital converter making it a good solution for low-power sensor nodes. The article discusses the most important security topics in wireless sensor networks and presents the architecture of the proposed hardware solution. Furthermore, it gives details on the chip implementation, verification and hardware evaluation. Finally, the chip power dissipation and performance figures are estimated and analyzed.
A fast mass spring model solver for high-resolution elastic objects
NASA Astrophysics Data System (ADS)
Zheng, Mianlun; Yuan, Zhiyong; Zhu, Weixu; Zhang, Guian
2017-03-01
Real-time simulation of elastic objects is of great importance for computer graphics and virtual reality applications. The fast mass spring model solver can achieve visually realistic simulation in an efficient way. Unfortunately, this method suffers from resolution limitations and lack of mechanical realism for a surface geometry model, which greatly restricts its application. To tackle these problems, in this paper we propose a fast mass spring model solver for high-resolution elastic objects. First, we project the complex surface geometry model into a set of uniform grid cells as cages through *cages mean value coordinate method to reflect its internal structure and mechanics properties. Then, we replace the original Cholesky decomposition method in the fast mass spring model solver with a conjugate gradient method, which can make the fast mass spring model solver more efficient for detailed surface geometry models. Finally, we propose a graphics processing unit accelerated parallel algorithm for the conjugate gradient method. Experimental results show that our method can realize efficient deformation simulation of 3D elastic objects with visual reality and physical fidelity, which has a great potential for applications in computer animation.
An Embedded Sensor Node Microcontroller with Crypto-Processors
Panić, Goran; Stecklina, Oliver; Stamenković, Zoran
2016-01-01
Wireless sensor network applications range from industrial automation and control, agricultural and environmental protection, to surveillance and medicine. In most applications, data are highly sensitive and must be protected from any type of attack and abuse. Security challenges in wireless sensor networks are mainly defined by the power and computing resources of sensor devices, memory size, quality of radio channels and susceptibility to physical capture. In this article, an embedded sensor node microcontroller designed to support sensor network applications with severe security demands is presented. It features a low power 16-bitprocessor core supported by a number of hardware accelerators designed to perform complex operations required by advanced crypto algorithms. The microcontroller integrates an embedded Flash and an 8-channel 12-bit analog-to-digital converter making it a good solution for low-power sensor nodes. The article discusses the most important security topics in wireless sensor networks and presents the architecture of the proposed hardware solution. Furthermore, it gives details on the chip implementation, verification and hardware evaluation. Finally, the chip power dissipation and performance figures are estimated and analyzed. PMID:27128925
ERIC Educational Resources Information Center
Illinois State Board of Education, Springfield. Dept. of School Improvement Services.
The thesis of this conference report is that acceleration is a much more effective method than remediation for bringing at-risk children into the educational mainstream at an early age. The papers summarized in the report provide a background on the history, politics, and demography of at-risk students and suggest applications of acceleration to…
NASA Astrophysics Data System (ADS)
Rout, Bibhudutta; Dhoubhadel, Mangal S.; Poudel, Prakash R.; Kummari, Venkata C.; Pandey, Bimal; Deoli, Naresh T.; Lakshantha, Wickramaarachchige J.; Mulware, Stephen J.; Baxley, Jacob; Manuel, Jack E.; Pacheco, Jose L.; Szilasi, Szabolcs; Weathers, Duncan L.; Reinert, Tilo; Glass, Gary A.; Duggan, Jerry L.; McDaniel, Floyd D.
2013-07-01
The Ion Beam Modification and Analysis Laboratory (IBMAL) at the University of North Texas includes several accelerator facilities with capabilities of producing a variety of ion beams from tens of keV to several MeV in energy. The four accelerators are used for research, graduate and undergraduate education, and industrial applications. The NEC 3MV Pelletron tandem accelerator has three ion sources for negative ions: He Alphatross and two different SNICS-type sputter ion sources. Presently, the tandem accelerator has four high-energy beam transport lines and one low-energy beam transport line directly taken from the negative ion sources for different research experiments. For the low-energy beam line, the ion energy can be varied from ˜20 to 80 keV for ion implantation/modification of materials. The four post-acceleration beam lines include a heavy-ion nuclear microprobe; multi-purpose PIXE, RBS, ERD, NRA, and broad-beam single-event upset; high-energy ion implantation line; and trace-element accelerator mass spectrometry. The NEC 3MV single-ended Pelletron accelerator has an RF ion source mainly for hydrogen, helium and heavier inert gases. We recently installed a capacitive liner to the terminal potential stabilization system for high terminal voltage stability and high-resolution microprobe analysis. The accelerator serves a beam line for standard RBS and RBS/C. Another beamline for high energy focused ion beam application using a magnetic quadrupole lens system is currently under construction. This beam line will also serve for developmental work on an electrostatic lens system. The third accelerator is a 200 kV Cockcroft-Walton accelerator with an RF ion source. The fourth accelerator is a 2.5 MV Van de Graaff accelerator, which was in operation for last several decades is currently planned to be used mainly for educational purpose. Research projects that will be briefly discussed include materials synthesis/modification for photonic, electronic, and magnetic applications, surface sputtering and micro-fabrication of materials, development of high-energy ion microprobe systems, and educational and outreach activities.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rout, Bibhudutta; Dhoubhadel, Mangal S.; Poudel, Prakash R.
2013-07-03
The Ion Beam Modification and Analysis Laboratory (IBMAL) at the University of North Texas includes several accelerator facilities with capabilities of producing a variety of ion beams from tens of keV to several MeV in energy. The four accelerators are used for research, graduate and undergraduate education, and industrial applications. The NEC 3MV Pelletron tandem accelerator has three ion sources for negative ions: He Alphatross and two different SNICS-type sputter ion sources. Presently, the tandem accelerator has four high-energy beam transport lines and one low-energy beam transport line directly taken from the negative ion sources for different research experiments. Formore » the low-energy beam line, the ion energy can be varied from {approx}20 to 80 keV for ion implantation/modification of materials. The four post-acceleration beam lines include a heavy-ion nuclear microprobe; multi-purpose PIXE, RBS, ERD, NRA, and broad-beam single-event upset; high-energy ion implantation line; and trace-element accelerator mass spectrometry. The NEC 3MV single-ended Pelletron accelerator has an RF ion source mainly for hydrogen, helium and heavier inert gases. We recently installed a capacitive liner to the terminal potential stabilization system for high terminal voltage stability and high-resolution microprobe analysis. The accelerator serves a beam line for standard RBS and RBS/C. Another beamline for high energy focused ion beam application using a magnetic quadrupole lens system is currently under construction. This beam line will also serve for developmental work on an electrostatic lens system. The third accelerator is a 200 kV Cockcroft-Walton accelerator with an RF ion source. The fourth accelerator is a 2.5 MV Van de Graaff accelerator, which was in operation for last several decades is currently planned to be used mainly for educational purpose. Research projects that will be briefly discussed include materials synthesis/modification for photonic, electronic, and magnetic applications, surface sputtering and micro-fabrication of materials, development of high-energy ion microprobe systems, and educational and outreach activities.« less
Particle-in-cell/accelerator code for space-charge dominated beam simulation
DOE Office of Scientific and Technical Information (OSTI.GOV)
2012-05-08
Warp is a multidimensional discrete-particle beam simulation program designed to be applicable where the beam space-charge is non-negligible or dominant. It is being developed in a collaboration among LLNL, LBNL and the University of Maryland. It was originally designed and optimized for heave ion fusion accelerator physics studies, but has received use in a broader range of applications, including for example laser wakefield accelerators, e-cloud studies in high enery accelerators, particle traps and other areas. At present it incorporates 3-D, axisymmetric (r,z) planar (x-z) and transverse slice (x,y) descriptions, with both electrostatic and electro-magnetic fields, and a beam envelope model.more » The code is guilt atop the Python interpreter language.« less
Accelerated Aging with Electrical Overstress and Prognostics for Power MOSFETs
NASA Technical Reports Server (NTRS)
Saha, Sankalita; Celaya, Jose Ramon; Vashchenko, Vladislav; Mahiuddin, Shompa; Goebel, Kai F.
2011-01-01
Power electronics play an increasingly important role in energy applications as part of their power converter circuits. Understanding the behavior of these devices, especially their failure modes as they age with nominal usage or sudden fault development is critical in ensuring efficiency. In this paper, a prognostics based health management of power MOSFETs undergoing accelerated aging through electrical overstress at the gate area is presented. Details of the accelerated aging methodology, modeling of the degradation process of the device and prognostics algorithm for prediction of the future state of health of the device are presented. Experiments with multiple devices demonstrate the performance of the model and the prognostics algorithm as well as the scope of application. Index Terms Power MOSFET, accelerated aging, prognostics
Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer
2015-12-01
preclinical models are representative of actual patient samples and may be useful in early drug development and predictive biomarker discovery...Award Number: W81XWH-11-1-0527 TITLE: Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer PRINCIPAL INVESTIGATOR: Aik...Choon Tan CONTRACTING ORGANIZATION: UNIVERSITY OF COLORADO, DENVER AURORA, CO 80045-2505 REPORT DATE: December 2015 TYPE OF REPORT: FINAL REPORT
Acceleration modules in linear induction accelerators
NASA Astrophysics Data System (ADS)
Wang, Shao-Heng; Deng, Jian-Jun
2014-05-01
The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.
NASA Astrophysics Data System (ADS)
Burlon, Alejandro A.; Girola, Santiago; Valda, Alejandro A.; Minsky, Daniel M.; Kreiner, Andrés J.
2010-08-01
In the frame of the construction of a Tandem Electrostatic Quadrupole Accelerator facility devoted to the Accelerator-Based Boron Neutron Capture Therapy, a Beam Shaping Assembly has been characterized by means of Monte-Carlo simulations and measurements. The neutrons were generated via the 7Li(p, n)7Be reaction by irradiating a thick LiF target with a 2.3 MeV proton beam delivered by the TANDAR accelerator at CNEA. The emerging neutron flux was measured by means of activation foils while the beam quality and directionality was evaluated by means of Monte Carlo simulations. The parameters show compliance with those suggested by IAEA. Finally, an improvement adding a beam collimator has been evaluated.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Plettner, T.; Byer, R.L.; Smith, T.I.
2006-02-17
We have observed acceleration of relativistic electrons in vacuum driven by a linearly polarized visible laser beam incident on a thin gold-coated reflective boundary. The observed energy modulation effect follows all the characteristics expected for linear acceleration caused by a longitudinal electric field. As predicted by the Lawson-Woodward theorem the laser driven modulation only appears in the presence of the boundary. It shows a linear dependence with the strength of the electric field of the laser beam and also it is critically dependent on the laser polarization. Finally, it appears to follow the expected angular dependence of the inverse transitionmore » radiation process. experiment as the Laser Electron Accelerator Project (LEAP).« less
Improved ETA-II accelerator performance
DOE Office of Scientific and Technical Information (OSTI.GOV)
Paul, A C; Boyd, J K; Chen, Y J
1999-03-22
Improvements have been made in the performance of the ETA-II accelerator that allow a nominal 2 kA, 6 MeV beam to be focused to a spot size less that 1 mm in diameter. The improvements include reducing the energy sweep to less than +/- 0.5 & over 40 ns of the pulse using a real time energy diagnostic and improving the magnetic tune of the accelerator to reduce the emittance to 8 cm-mrad. Finally, an automated tuning system (MAESTRO) was run to minimize the time dependent centroid motion (corkscrew) by adjusting the steering dipoles over the focusing solenoids. The corkscrewmore » motion was reduced to less than +/- 0.5 mm at the output of the accelerator.« less
Small Molecule Organic Optoelectronic Devices
NASA Astrophysics Data System (ADS)
Bakken, Nathan
Organic optoelectronics include a class of devices synthesized from carbon containing 'small molecule' thin films without long range order crystalline or polymer structure. Novel properties such as low modulus and flexibility as well as excellent device performance such as photon emission approaching 100% internal quantum efficiency have accelerated research in this area substantially. While optoelectronic organic light emitting devices have already realized commercial application, challenges to obtain extended lifetime for the high energy visible spectrum and the ability to reproduce natural white light with a simple architecture have limited the value of this technology for some display and lighting applications. In this research, novel materials discovered from a systematic analysis of empirical device data are shown to produce high quality white light through combination of monomer and excimer emission from a single molecule: platinum(II) bis(methyl-imidazolyl)toluene chloride (Pt-17). Illumination quality achieved Commission Internationale de L'Eclairage (CIE) chromaticity coordinates (x = 0.31, y = 0.38) and color rendering index (CRI) > 75. Further optimization of a device containing Pt-17 resulted in a maximum forward viewing power efficiency of 37.8 lm/W on a plain glass substrate. In addition, accelerated aging tests suggest high energy blue emission from a halogen-free cyclometalated platinum complex could demonstrate degradation rates comparable to known stable emitters. Finally, a buckling based metrology is applied to characterize the mechanical properties of small molecule organic thin films towards understanding the deposition kinetics responsible for an elastic modulus that is both temperature and thickness dependent. These results could contribute to the viability of organic electronic technology in potentially flexible display and lighting applications. The results also provide insight to organic film growth kinetics responsible for optical, mechanical, and water uptake properties relevant to engineering the next generation of optoelectronic devices.
Application of a nonlinear slug test model
McElwee, C.D.
2001-01-01
Knowledge of the hydraulic conductivity distribution is of utmost importance in understanding the dynamics of an aquifer and in planning the consequences of any action taken upon that aquifer. Slug tests have been used extensively to measure hydraulic conductivity in the last 50 years since Hvorslev's (1951) work. A general nonlinear model based on the Navier-Stokes equation, nonlinear frictional loss, non-Darcian flow, acceleration effects, radius changes in the wellbore, and a Hvorslev model for the aquifer has been implemented in this work. The nonlinear model has three parameters: ??, which is related primarily to radius changes in the water column; A, which is related to the nonlinear head losses; and K, the hydraulic conductivity. An additional parameter has been added representing the initial velocity of the water column at slug initiation and is incorporated into an analytical solution to generate the first time step before a sequential numerical solution generates the remainder of the time solution. Corrections are made to the model output for acceleration before it is compared to the experimental data. Sensitivity analysis and least squares fitting are used to estimate the aquifer parameters and produce some diagnostic results, which indicate the accuracy of the fit. Finally, an example of field data has been presented to illustrate the application of the model to data sets that exhibit nonlinear behavior. Multiple slug tests should be taken at a given location to test for nonlinear effects and to determine repeatability.
ALON® Components With Tunable Dielectric Properties for High Power Accelerator Applications
DOE Office of Scientific and Technical Information (OSTI.GOV)
Goldman, Lee M; Jha, Santosh K; Lobur, Nicole
There are challenges in linear particle accelerators associated with the need to suppress “higher order modes” (HOMs). HOMs are detrimental to accelerator operation as they are a source of beam instability. The absorption/suppression of HOMs and dissipation of the energy of higher order modes is vital to the function of these accelerators. Surmet has identified ALON® Optical Ceramic (Aluminum Oxynitride), a hard, durable ceramic that is fabricated through conventional powder processing techniques, as a potential material for HOM absorber. In this Phase I program, Surmet has produced new ALON-composite HOM absorber materials that function at both ambient and cryogenic temperatures.more » The composite materials were developed and evaluated in collaboration with Thomas Jefferson National Labs. Success in this Phase I and the potential Phase II will demonstrate the utility of ALON composite components for RF absorbing applications and lay the groundwork for commercialization of such products, with applications in basic science, medical and digital electronics industries.« less
NASA Astrophysics Data System (ADS)
Audebert, P.
2007-11-01
In the last few years, intense research has been conducted on laser-accelerated ion sources and their applications. These sources have exceptional properties, i.e. high brightness and high spectral cut-off, high directionality and laminarity, short burst duration. We have shown that for proton energies >10 MeV, the transverse and longitudinal emittance are respectively <0.004 mm-mrad and <10-4 eV-s, i.e. at least 100-fold and may be as much as 10^4-fold better than conventional accelerators beams. Thanks to these properties, these sources allow for example point-projection radiography with unprecedented resolution. We will show example of such time and space-resolved radiography of fast evolving fields, either of associated with the expansion of a plasma in vacuum [*] or with the propagation of a ICF-relevant laser beam in an underdense plasma. These proton sources also open new opportunities for ion beam generation and control, and could stimulate development of compact ion accelerators for many applications.
Austin, S Bryn
2016-01-01
The public health burden of eating disorders is well documented, and over the past several decades, researchers have made important advances in the prevention of eating disorders and related problems with body image. Despite these advances, however, several critical limitations to the approaches developed to date leave the field far from achieving the large-scale impact that is needed. This commentary provides a brief review of what achievements in prevention have been made and identifies the gaps that limit the potential for greater impact on population health. A plan is then offered with specific action steps to accelerate progress in high-impact prevention, most compellingly by promoting a shift in priorities to policy translation research and training for scholars through the adoption of a triggers-to-action framework. Finally, the commentary provides an example of the application of the triggers-to-action framework as practiced at the Strategic Training Initiative for the Prevention of Eating Disorders, a program based at the Harvard T. H. Chan School of Public Health and Boston Children's Hospital. Much has been achieved in the nearly 30 years of research carried out for the prevention of eating disorders and body image problems, but several critical limitations undermine the field's potential for meaningful impact. Through a shift in the field's priorities to policy translation research and training with an emphasis on macro-environmental influences, the pace of progress in prevention can be accelerated and the potential for large-scale impact substantially improved.
Temporal Electron-bunch Shaping from a Photoinjector for Advanced Accelerator Applications
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lemery, Francois; Piot, Philippe
2014-07-01
Advanced-accelerator applications often require the production of bunches with shaped temporal distributions. An example of sought-after shape is a linearly-ramped current profile that can be improve the transformer ratio in beam-driven acceleration, or produce energy-modulated pulse for, e.g., the subsequent generation of THz radiation. Typically, such a shaping is achieved by manipulating ultra-relativistic electron bunches. In this contribution we discuss the possibility of shaping the bunch via photoemission and demonstrate using particle-in-cell simulations the production of MeV electron bunches with quasi-ramped current profile.
Time-to-contact estimation of accelerated stimuli is based on first-order information.
Benguigui, Nicolas; Ripoll, Hubert; Broderick, Michael P
2003-12-01
The goal of this study was to test whether 1st-order information, which does not account for acceleration, is used (a) to estimate the time to contact (TTC) of an accelerated stimulus after the occlusion of a final part of its trajectory and (b) to indirectly intercept an accelerated stimulus with a thrown projectile. Both tasks require the production of an action on the basis of predictive information acquired before the arrival of the stimulus at the target and allow the experimenter to make quantitative predictions about the participants' use (or nonuse) of 1st-order information. The results show that participants do not use information about acceleration and that they commit errors that rely quantitatively on 1st-order information even when acceleration is psychophysically detectable. In the indirect interceptive task, action is planned about 200 ms before the initiation of the movement, at which time the 1st-order TTC attains a critical value. ((c) 2003 APA, all rights reserved)
Gyrokinetic theory of turbulent acceleration and momentum conservation in tokamak plasmas
NASA Astrophysics Data System (ADS)
Lu, WANG; Shuitao, PENG; P, H. DIAMOND
2018-07-01
Understanding the generation of intrinsic rotation in tokamak plasmas is crucial for future fusion reactors such as ITER. We proposed a new mechanism named turbulent acceleration for the origin of the intrinsic parallel rotation based on gyrokinetic theory. The turbulent acceleration acts as a local source or sink of parallel rotation, i.e., volume force, which is different from the divergence of residual stress, i.e., surface force. However, the order of magnitude of turbulent acceleration can be comparable to that of the divergence of residual stress for electrostatic ion temperature gradient (ITG) turbulence. A possible theoretical explanation for the experimental observation of electron cyclotron heating induced decrease of co-current rotation was also proposed via comparison between the turbulent acceleration driven by ITG turbulence and that driven by collisionless trapped electron mode turbulence. We also extended this theory to electromagnetic ITG turbulence and investigated the electromagnetic effects on intrinsic parallel rotation drive. Finally, we demonstrated that the presence of turbulent acceleration does not conflict with momentum conservation.
Modeling target normal sheath acceleration using handoffs between multiple simulations
NASA Astrophysics Data System (ADS)
McMahon, Matthew; Willis, Christopher; Mitchell, Robert; King, Frank; Schumacher, Douglass; Akli, Kramer; Freeman, Richard
2013-10-01
We present a technique to model the target normal sheath acceleration (TNSA) process using full-scale LSP PIC simulations. The technique allows for a realistic laser, full size target and pre-plasma, and sufficient propagation length for the accelerated ions and electrons. A first simulation using a 2D Cartesian grid models the laser-plasma interaction (LPI) self-consistently and includes field ionization. Electrons accelerated by the laser are imported into a second simulation using a 2D cylindrical grid optimized for the initial TNSA process and incorporating an equation of state. Finally, all of the particles are imported to a third simulation optimized for the propagation of the accelerated ions and utilizing a static field solver for initialization. We also show use of 3D LPI simulations. Simulation results are compared to recent ion acceleration experiments using SCARLET laser at The Ohio State University. This work was performed with support from ASOFR under contract # FA9550-12-1-0341, DARPA, and allocations of computing time from the Ohio Supercomputing Center.
Accelerated and Airy-Bloch oscillations
NASA Astrophysics Data System (ADS)
Longhi, Stefano
2016-09-01
A quantum particle subjected to a constant force undergoes an accelerated motion following a parabolic path, which differs from the classical motion just because of wave packet spreading (quantum diffusion). However, when a periodic potential is added (such as in a crystal) the particle undergoes Bragg scattering and an oscillatory (rather than accelerated) motion is found, corresponding to the famous Bloch oscillations (BOs). Here, we introduce an exactly-solvable quantum Hamiltonian model, corresponding to a generalized Wannier-Stark Hamiltonian Ĥ, in which a quantum particle shows an intermediate dynamical behavior, namely an oscillatory motion superimposed to an accelerated one. Such a novel dynamical behavior is referred to as accelerated BOs. Analytical expressions of the spectrum, improper eigenfunctions and propagator of the generalized Wannier-Stark Hamiltonian Ĥ are derived. Finally, it is shown that acceleration and quantum diffusion in the generalized Wannier-Stark Hamiltonian are prevented for Airy wave packets, which undergo a periodic breathing dynamics that can be referred to as Airy-Bloch oscillations.
NASA Astrophysics Data System (ADS)
Miano, Alberto Claudio; Pereira, Jessica Da Costa; Castanha, Nanci; Júnior, Manoel Divino Da Matta; Augusto, Pedro Esteves Duarte
2016-12-01
The ultrasound technology was successfully used to improve the mass transfer processes on food. However, the study of this technology on the grain hydration and on its main components properties was still not appropriately described. This work studied the application of the ultrasound technology on the hydration process of mung beans (Vigna radiata). This grain showed sigmoidal hydration behavior with a specific water entrance pathway. The ultrasound reduced ~25% of the hydration process time. In addition, this technology caused acceleration of the seed germination - and some hypothesis for this enhancement were proposed. Moreover, it was demonstrated that the ultrasound did not change both structure and pasting properties of the bean starch. Finally, the flour rheological properties proved that the ultrasound increased its apparent viscosity, and as the starch was not modified, this alteration was attributed to the proteins. All these results are very desirable for industry since the ultrasound technology improves the hydration process without altering the starch properties, accelerates the germination process (that is important for the malting and sprouting process) and increases the flour apparent viscosity, which is desirable to produce bean-based products that need higher consistency.
NASA Astrophysics Data System (ADS)
Coindreau, O.; Duriez, C.; Ederli, S.
2010-10-01
Progress in the treatment of air oxidation of zirconium in severe accident (SA) codes are required for a reliable analysis of severe accidents involving air ingress. Air oxidation of zirconium can actually lead to accelerated core degradation and increased fission product release, especially for the highly-radiotoxic ruthenium. This paper presents a model to simulate air oxidation kinetics of Zircaloy-4 in the 600-1000 °C temperature range. It is based on available experimental data, including separate-effect experiments performed at IRSN and at Forschungszentrum Karlsruhe. The kinetic transition, named "breakaway", from a diffusion-controlled regime to an accelerated oxidation is taken into account in the modeling via a critical mass gain parameter. The progressive propagation of the locally initiated breakaway is modeled by a linear increase in oxidation rate with time. Finally, when breakaway propagation is completed, the oxidation rate stabilizes and the kinetics is modeled by a linear law. This new modeling is integrated in the severe accident code ASTEC, jointly developed by IRSN and GRS. Model predictions and experimental data from thermogravimetric results show good agreement for different air flow rates and for slow temperature transient conditions.
Evolution of accelerometer methods for physical activity research.
Troiano, Richard P; McClain, James J; Brychta, Robert J; Chen, Kong Y
2014-07-01
The technology and application of current accelerometer-based devices in physical activity (PA) research allow the capture and storage or transmission of large volumes of raw acceleration signal data. These rich data not only provide opportunities to improve PA characterisation, but also bring logistical and analytic challenges. We discuss how researchers and developers from multiple disciplines are responding to the analytic challenges and how advances in data storage, transmission and big data computing will minimise logistical challenges. These new approaches also bring the need for several paradigm shifts for PA researchers, including a shift from count-based approaches and regression calibrations for PA energy expenditure (PAEE) estimation to activity characterisation and EE estimation based on features extracted from raw acceleration signals. Furthermore, a collaborative approach towards analytic methods is proposed to facilitate PA research, which requires a shift away from multiple independent calibration studies. Finally, we make the case for a distinction between PA represented by accelerometer-based devices and PA assessed by self-report. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Beltrán, F R; Lorenzo, V; Acosta, J; de la Orden, M U; Martínez Urreaga, J
2018-06-15
The aim of this work is to study the effects of different simulated mechanical recycling processes on the structure and properties of PLA. A commercial grade of PLA was melt compounded and compression molded, then subjected to two different recycling processes. The first recycling process consisted of an accelerated ageing and a second melt processing step, while the other recycling process included an accelerated ageing, a demanding washing process and a second melt processing step. The intrinsic viscosity measurements indicate that both recycling processes produce a degradation in PLA, which is more pronounced in the sample subjected to the washing process. DSC results suggest an increase in the mobility of the polymer chains in the recycled materials; however the degree of crystallinity of PLA seems unchanged. The optical, mechanical and gas barrier properties of PLA do not seem to be largely affected by the degradation suffered during the different recycling processes. These results suggest that, despite the degradation of PLA, the impact of the different simulated mechanical recycling processes on the final properties is limited. Thus, the potential use of recycled PLA in packaging applications is not jeopardized. Copyright © 2017 Elsevier Ltd. All rights reserved.
The Master Equation for Two-Level Accelerated Systems at Finite Temperature
NASA Astrophysics Data System (ADS)
Tomazelli, J. L.; Cunha, R. O.
2016-10-01
In this work, we study the behaviour of two weakly coupled quantum systems, described by a separable density operator; one of them is a single oscillator, representing a microscopic system, while the other is a set of oscillators which perform the role of a reservoir in thermal equilibrium. From the Liouville-Von Neumann equation for the reduced density operator, we devise the master equation that governs the evolution of the microscopic system, incorporating the effects of temperature via Thermofield Dynamics formalism by suitably redefining the vacuum of the macroscopic system. As applications, we initially investigate the behaviour of a Fermi oscillator in the presence of a heat bath consisting of a set of Fermi oscillators and that of an atomic two-level system interacting with a scalar radiation field, considered as a reservoir, by constructing the corresponding master equation which governs the time evolution of both sub-systems at finite temperature. Finally, we calculate the energy variation rates for the atom and the field, as well as the atomic population levels, both in the inertial case and at constant proper acceleration, considering the two-level system as a prototype of an Unruh detector, for admissible couplings of the radiation field.
Grisham, Larry R
2013-12-17
The present invention provides systems and methods for the magnetic insulation of accelerator electrodes in electrostatic accelerators. Advantageously, the systems and methods of the present invention improve the practically obtainable performance of these electrostatic accelerators by addressing, among other things, voltage holding problems and conditioning issues. The problems and issues are addressed by flowing electric currents along these accelerator electrodes to produce magnetic fields that envelope the accelerator electrodes and their support structures, so as to prevent very low energy electrons from leaving the surfaces of the accelerator electrodes and subsequently picking up energy from the surrounding electric field. In various applications, this magnetic insulation must only produce modest gains in voltage holding capability to represent a significant achievement.
Introduction to Particle Acceleration in the Cosmos
NASA Technical Reports Server (NTRS)
Gallagher, D. L.; Horwitz, J. L.; Perez, J.; Quenby, J.
2005-01-01
Accelerated charged particles have been used on Earth since 1930 to explore the very essence of matter, for industrial applications, and for medical treatments. Throughout the universe nature employs a dizzying array of acceleration processes to produce particles spanning twenty orders of magnitude in energy range, while shaping our cosmic environment. Here, we introduce and review the basic physical processes causing particle acceleration, in astrophysical plasmas from geospace to the outer reaches of the cosmos. These processes are chiefly divided into four categories: adiabatic and other forms of non-stochastic acceleration, magnetic energy storage and stochastic acceleration, shock acceleration, and plasma wave and turbulent acceleration. The purpose of this introduction is to set the stage and context for the individual papers comprising this monograph.
Accelerating execution of the integrated TIGER series Monte Carlo radiation transport codes
DOE Office of Scientific and Technical Information (OSTI.GOV)
Smith, L.M.; Hochstedler, R.D.
1997-02-01
Execution of the integrated TIGER series (ITS) of coupled electron/photon Monte Carlo radiation transport codes has been accelerated by modifying the FORTRAN source code for more efficient computation. Each member code of ITS was benchmarked and profiled with a specific test case that directed the acceleration effort toward the most computationally intensive subroutines. Techniques for accelerating these subroutines included replacing linear search algorithms with binary versions, replacing the pseudo-random number generator, reducing program memory allocation, and proofing the input files for geometrical redundancies. All techniques produced identical or statistically similar results to the original code. Final benchmark timing of themore » accelerated code resulted in speed-up factors of 2.00 for TIGER (the one-dimensional slab geometry code), 1.74 for CYLTRAN (the two-dimensional cylindrical geometry code), and 1.90 for ACCEPT (the arbitrary three-dimensional geometry code).« less
Dilution jets in accelerated cross flows. Ph.D. Thesis Final Report
NASA Technical Reports Server (NTRS)
Lipshitz, A.; Greber, I.
1984-01-01
Results of flow visualization experiments and measurements of the temperature field produced by a single jet and a row of dilution jets issued into a reverse flow combustor are presented. The flow in such combustors is typified by transverse and longitudinal acceleration during the passage through its bending section. The flow visualization experiments are designed to examine the separate effects of longitudinal and transverse acceleration on the jet trajectory and spreading rate. A model describing a dense single jet in a lighter accelerating cross flow is developed. The model is based on integral conservation equations, including the pressure terms appropriate to accelerating flows. It uses a modified entrainment correlation obtained from previous experiments of a jet in a cross stream. The flow visualization results are compared with the model calculations in terms of trajectories and spreading rates. Each experiment is typified by a set of three parameters: momentum ratio, density ratio and the densimetric Froude number.
Advances in high gradient normal conducting accelerator structures
Simakov, Evgenya Ivanovna; Dolgashev, Valery A.; Tantawi, Sami G.
2018-03-09
Here, this paper reviews the current state-of-the-art in understanding the phenomena of ultra-high vacuum radio-frequency (rf) breakdown in accelerating structures and the efforts to improve stable operation of the structures at accelerating gradients above 100 MV/m. Numerous studies have been conducted recently with the goal of understanding the dependence of the achievable accelerating gradients and breakdown rates on the frequency of operations, the geometry of the structure, material and method of fabrication, and operational temperature. Tests have been conducted with single standing wave accelerator cells as well as with the multi-cell traveling wave structures. Notable theoretical effort was directed atmore » understanding the physical mechanisms of the rf breakdown and its statistical behavior. Finally, the achievements presented in this paper are the result of the large continuous self-sustaining collaboration of multiple research institutions in the United States and worldwide.« less
Extended Task Space Control for Robotic Manipulators
NASA Technical Reports Server (NTRS)
Backes, Paul G. (Inventor); Long, Mark K. (Inventor)
1996-01-01
The invention is a method of operating a robot in successive sampling intervals to perform a task, the robot having joints and joint actuators with actuator control loops, by decomposing the task into behavior forces, accelerations, velocities and positions of plural behaviors to be exhibited by the robot simultaneously, computing actuator accelerations of the joint actuators for the current sampling interval from both behavior forces, accelerations velocities and positions of the current sampling interval and actuator velocities and positions of the previous sampling interval, computing actuator velocities and positions of the joint actuators for the current sampling interval from the actuator velocities and positions of the previous sampling interval, and, finally, controlling the actuators in accordance with the actuator accelerations, velocities and positions of the current sampling interval. The actuator accelerations, velocities and positions of the current sampling interval are stored for use during the next sampling interval.
Advances in high gradient normal conducting accelerator structures
DOE Office of Scientific and Technical Information (OSTI.GOV)
Simakov, Evgenya Ivanovna; Dolgashev, Valery A.; Tantawi, Sami G.
Here, this paper reviews the current state-of-the-art in understanding the phenomena of ultra-high vacuum radio-frequency (rf) breakdown in accelerating structures and the efforts to improve stable operation of the structures at accelerating gradients above 100 MV/m. Numerous studies have been conducted recently with the goal of understanding the dependence of the achievable accelerating gradients and breakdown rates on the frequency of operations, the geometry of the structure, material and method of fabrication, and operational temperature. Tests have been conducted with single standing wave accelerator cells as well as with the multi-cell traveling wave structures. Notable theoretical effort was directed atmore » understanding the physical mechanisms of the rf breakdown and its statistical behavior. Finally, the achievements presented in this paper are the result of the large continuous self-sustaining collaboration of multiple research institutions in the United States and worldwide.« less
Hermetic diode laser transmitter module
NASA Astrophysics Data System (ADS)
Ollila, Jyrki; Kautio, Kari; Vahakangas, Jouko; Hannula, Tapio; Kopola, Harri K.; Oikarinen, Jorma; Sivonen, Matti
1999-04-01
In very demanding optoelectronic sensor applications it is necessary to encapsulate semiconductor components hermetically in metal housings to ensure reliable operation of the sensor. In this paper we report on the development work to package a laser diode transmitter module for a time- off-light distance sensor application. The module consists of a lens, laser diode, electronic circuit and optomechanics. Specifications include high acceleration, -40....+75 degree(s)C temperature range, very low gas leakage and mass-production capability. We have applied solder glasses for sealing optical lenses and electrical leads hermetically into a metal case. The lens-metal case sealing has been made by using a special soldering glass preform preserving the optical quality of the lens. The metal housings are finally sealed in an inert atmosphere by welding. The assembly concept to retain excellent optical power and tight optical axis alignment specifications is described. The reliability of the laser modules manufactured has been extensively tested using different aging and environmental test procedures. Sealed packages achieve MIL- 883 standard requirements for gas leakage.
May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells.
Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David A
2017-02-06
In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Larson, N.M.
1984-02-01
This report describes a computer code (ALEX) developed to assist in AnaLysis of EXperimental data at the Oak Ridge Electron Linear Accelerator (ORELA). Reduction of data from raw numbers (counts per channel) to physically meaningful quantities (such as cross sections) is in itself a complicated procedure; propagation of experimental uncertainties through that reduction procedure has in the past been viewed as even more difficult - if not impossible. The purpose of the code ALEX is to correctly propagate all experimental uncertainties through the entire reduction procedure, yielding the complete covariance matrix for the reduced data, while requiring little additional inputmore » from the eperimentalist beyond that which is required for the data reduction itself. This report describes ALEX in detail, with special attention given to the case of transmission measurements (the code itself is applicable, with few changes, to any type of data). Application to the natural iron measurements of D.C. Larson et al. is described in some detail.« less
May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells
Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David. A.
2017-01-01
In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods. PMID:28178187
Systems Engineering Metrics: Organizational Complexity and Product Quality Modeling
NASA Technical Reports Server (NTRS)
Mog, Robert A.
1997-01-01
Innovative organizational complexity and product quality models applicable to performance metrics for NASA-MSFC's Systems Analysis and Integration Laboratory (SAIL) missions and objectives are presented. An intensive research effort focuses on the synergistic combination of stochastic process modeling, nodal and spatial decomposition techniques, organizational and computational complexity, systems science and metrics, chaos, and proprietary statistical tools for accelerated risk assessment. This is followed by the development of a preliminary model, which is uniquely applicable and robust for quantitative purposes. Exercise of the preliminary model using a generic system hierarchy and the AXAF-I architectural hierarchy is provided. The Kendall test for positive dependence provides an initial verification and validation of the model. Finally, the research and development of the innovation is revisited, prior to peer review. This research and development effort results in near-term, measurable SAIL organizational and product quality methodologies, enhanced organizational risk assessment and evolutionary modeling results, and 91 improved statistical quantification of SAIL productivity interests.
Application of metabolic engineering for the biotechnological production of L-valine.
Oldiges, Marco; Eikmanns, Bernhard J; Blombach, Bastian
2014-07-01
The branched chain amino acid L-valine is an essential nutrient for higher organisms, such as animals and humans. Besides the pharmaceutical application in parenteral nutrition and as synthon for the chemical synthesis of e.g. herbicides or anti-viral drugs, L-valine is now emerging into the feed market, and significant increase of sales and world production is expected. In accordance, well-known microbial production bacteria, such as Escherichia coli and Corynebacterium glutamicum strains, have recently been metabolically engineered for efficient L-valine production under aerobic or anaerobic conditions, and the respective cultivation and production conditions have been optimized. This review summarizes the state of the art in L-valine biosynthesis and its regulation in E. coli and C. glutamicum with respect to optimal metabolic network for microbial L-valine production, genetic strain engineering and bioprocess development for L-valine production, and finally, it will shed light on emerging technologies that have the potential to accelerate strain and bioprocess engineering in the near future.
Radial carpet beams: A class of nondiffracting, accelerating, and self-healing beams
NASA Astrophysics Data System (ADS)
Rasouli, Saifollah; Khazaei, Ali Mohammad; Hebri, Davud
2018-03-01
Self-accelerating shape-invariant beams are attracting major attention, presenting applications in many areas such as laser manipulation and patterning, light-sheet microscopy, and plasma channels. Moreover, optical lattices are offering many applications, including quantum computation, quantum phase transition, spin-exchange interaction, and realization of magnetic fields. We report observation of a class of accelerating and self-healing beams which covers the features required by all the aforementioned applications. These beams are accelerating, shape invariant, and self-healing for more than several tens of meters, have numerous phase anomalies and unprecedented patterns, and can be feasibly tuned. Diffraction of a plane wave from radial phase gratings generates such beams, and due to their beauty and structural complexity we have called them "carpet" beams. By tuning the value of phase variations over the grating, the resulting carpet patterns are converted into two-dimensional optical lattices with polar symmetry. Furthermore, the number of spokes in the radial grating, phase variation amplitude, and wavelength of the impinging light beam can also be adjusted to obtain additional features. We believe that radial carpet beams and lattices might find more applications in optical micromanipulation, optical lithography, super-resolution imaging, lighting design, optical communication through atmosphere, etc.
Dynamics of High Temperature Plasmas.
1985-10-01
25 VI. > LASER BEAT WAVE PARTICLE ACCELERATION-.. ..... .. 27 ,, VII. ORBITRON MASER DESIGN .. ..... ............. 30 0 VIIM> ELECTRON BEAM STABILITY...IN THE MODIFIED BETATRON .... ............ 32 IX. * RELATIVISTIC ELECTRON BEAM DIODE DESIGN . . . . 35 X. FREE ELECTRON LASER APPLICATION TO XUV...Accelerators (B), VI. Laser Beat Wave Particle Acceleration, VII. Orbitron Maser Design , VIII. Electron Beam Stability in the Modified Betatron, IX
Radioactive ion beam acceleration at MAFF
NASA Astrophysics Data System (ADS)
Pasini, M.; Kester, O.; Habs, D.; Groß, M.; Sieber, T.; Maier, H. J.; Assmann, W.; Krüken, R.; Faestermann, T.; Schempp, A.; Ratzinger, U.; Safvan, C. P.
2004-12-01
In April 2003, the German safety commission has given the final approval for the oper- ation of the high flux reactor FRM-II. This is an important step towards the development and installation of the Munich accelerator for fission fragments (MAFF), which will deliver highest intensities of neutron rich fission fragments. The acceleration chain of MAFF [1] consists of a charge breeder, which will deliver the ions with a mass to charge ratio of A/q ⩽ 6.3 irrespective of the mass range, and with a repetition rate of maximum 50 Hz. The LINAC operating at 10% duty cycle is composed of a 101.28 IH-RFQ, which will boost up the energy from 2.5 up to 300 keV/u, three IH-tanks that will deliver an energy of 5.4 MeV/u and 2 seven gap IH-resonators that are used to vary the final energy up to a maximum of 5.9 MeV/u. Currently beam dynamics revisions are in progress especially in the low energy section, since the experimental program has requested specific time structures of the beam for TOF experiments. The status of the beam dynamics studies as well as the status of the single components of the accelerator will be presented in this paper.
Laser-driven ion acceleration: methods, challenges and prospects
NASA Astrophysics Data System (ADS)
Badziak, J.
2018-01-01
The recent development of laser technology has resulted in the construction of short-pulse lasers capable of generating fs light pulses with PW powers and intensities exceeding 1021 W/cm2, and has laid the basis for the multi-PW lasers, just being built in Europe, that will produce fs pulses of ultra-relativistic intensities ~ 1023 - 1024 W/cm2. The interaction of such an intense laser pulse with a dense target can result in the generation of collimated beams of ions of multi-MeV to GeV energies of sub-ps time durations and of extremely high beam intensities and ion fluencies, barely attainable with conventional RF-driven accelerators. Ion beams with such unique features have the potential for application in various fields of scientific research as well as in medical and technological developments. This paper provides a brief review of state-of-the art in laser-driven ion acceleration, with a focus on basic ion acceleration mechanisms and the production of ultra-intense ion beams. The challenges facing laser-driven ion acceleration studies, in particular those connected with potential applications of laser-accelerated ion beams, are also discussed.
Anderson Acceleration for Fixed-Point Iterations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Walker, Homer F.
The purpose of this grant was to support research on acceleration methods for fixed-point iterations, with applications to computational frameworks and simulation problems that are of interest to DOE.
An optimized small animal tumour model for experimentation with low energy protons.
Beyreuther, Elke; Brüchner, Kerstin; Krause, Mechthild; Schmidt, Margret; Szabo, Rita; Pawelke, Jörg
2017-01-01
The long-term aim of developing laser based particle acceleration towards clinical application requires not only substantial technological progress, but also the radiobiological characterization of the resulting ultra-short and ultra-intensive particle beam pulses. After comprehensive cell studies a mouse ear tumour model was established allowing for the penetration of low energy protons (~20 MeV) currently available at laser driven accelerators. The model was successfully applied for a first tumour growth delay study with laser driven electrons, whereby the need of improvements crop out. To optimise the mouse ear tumour model with respect to a stable, high take rate and a lower number of secondary tumours, Matrigel was introduced for tumour cell injection. Different concentrations of two human tumour cell lines (FaDu, LN229) and Matrigel were evaluated for stable tumour growth and fulfilling the allocation criteria for irradiation experiments. The originally applied cell injection with PBS was performed for comparison and to assess the long-term stability of the model. Finally, the optimum suspension of cells and Matrigel was applied to determine applicable dose ranges for tumour growth delay studies by 200 kV X-ray irradiation. Both human tumour models showed a high take rate and exponential tumour growth starting at a volume of ~10 mm3. As disclosed by immunofluorescence analysis these small tumours already interact with the surrounding tissue and activate endothelial cells to form vessels. The formation of delimited, solid tumours at irradiation size was shown by standard H&E staining and a realistic dose range for inducing tumour growth delay without permanent tumour control was obtained for both tumour entities. The already established mouse ear tumour model was successfully upgraded now providing stable tumour growth with high take rate for two tumour entities (HNSCC, glioblastoma) that are of interest for future irradiation experiments at experimental accelerators.
Final Report for "Design calculations for high-space-charge beam-to-RF conversion".
DOE Office of Scientific and Technical Information (OSTI.GOV)
David N Smithe
2008-10-17
Accelerator facility upgrades, new accelerator applications, and future design efforts are leading to novel klystron and IOT device concepts, including multiple beam, high-order mode operation, and new geometry configurations of old concepts. At the same time, a new simulation capability, based upon finite-difference “cut-cell” boundaries, has emerged and is transforming the existing modeling and design capability with unparalleled realism, greater flexibility, and improved accuracy. This same new technology can also be brought to bear on a difficult-to-study aspect of the energy recovery linac (ERL), namely the accurate modeling of the exit beam, and design of the beam dump for optimummore » energy efficiency. We have developed new capability for design calculations and modeling of a broad class of devices which convert bunched beam kinetic energy to RF energy, including RF sources, as for example, klystrons, gyro-klystrons, IOT's, TWT’s, and other devices in which space-charge effects are important. Recent advances in geometry representation now permits very accurate representation of the curved metallic surfaces common to RF sources, resulting in unprecedented simulation accuracy. In the Phase I work, we evaluated and demonstrated the capabilities of the new geometry representation technology as applied to modeling and design of output cavity components of klystron, IOT's, and energy recovery srf cavities. We identified and prioritized which aspects of the design study process to pursue and improve in Phase II. The development and use of the new accurate geometry modeling technology on RF sources for DOE accelerators will help spark a new generational modeling and design capability, free from many of the constraints and inaccuracy associated with the previous generation of “stair-step” geometry modeling tools. This new capability is ultimately expected to impact all fields with high power RF sources, including DOE fusion research, communications, radar and other defense applications.« less
NASA Technical Reports Server (NTRS)
Martin, E. Dale
1961-01-01
A study is made of the steady laminar flow of a compressible viscous fluid in a circular pipe when the fluid is accelerated by an axial body force. The application of the theory to the magnetofluidmechanics of an electrically conducting gas accelerated by electric and magnetic fields is discussed. Constant viscosity, thermal conductivity, and electrical conductivity are assumed. Fully developed flow velocity and temperature profiles are shown, and detailed results of the accelerating flow development, including velocity and pressure as functions of distance, are given for the case where the axial body force is constant and for the case where it is a linear function of velocity. From these results are determined the pipe entry length and the pressure difference required.
Electrostatic accelerators with high energy resolution
NASA Astrophysics Data System (ADS)
Uchiyama, T.; Agawa, Y.; Nishihashi, T.; Takagi, K.; Yamakawa, H.; Isoya, A.; Takai, M.; Namba, S.
1991-05-01
Several models of electrostatic accelerators based on rotating disks (Disktron) have been manufactured for various ion beam applications like surface analyses and implantation. The high voltage terminal of the Disktron with a terminal voltage of up to 500 kV is open in air, while the generator part is enclosed in FRP (fiber reinforced plastics) or a ceramic vessel filled with sf 6 gas. The 1 MV model is completely enclosed in a steel vessel. A compact tandem accelerator of the pellet chain type with a terminal voltage of 1.5 MV has also been manufactured. The good energy stability of these accelerators, typically in the range of 10 -4, has proved to be quite favorable for applications in precise studies of material surfaces, including the use of microbeam techniques.
Essay: Robert H. Siemann As Leader of the Advanced Accelerator Research Department
DOE Office of Scientific and Technical Information (OSTI.GOV)
Colby, Eric R.; Hogan, Mark J.; /SLAC
Robert H. Siemann originally conceived of the Advanced Accelerator Research Department (AARD) as an academic, experimental group dedicated to probing the technical limitations of accelerators while providing excellent educational opportunities for young scientists. The early years of the Accelerator Research Department B, as it was then known, were dedicated to a wealth of mostly student-led experiments to examine the promise of advanced accelerator techniques. High-gradient techniques including millimeter-wave rf acceleration, beam-driven plasma acceleration, and direct laser acceleration were pursued, including tests of materials under rf pulsed heating and short-pulse laser radiation, to establish the ultimate limitations on gradient. As themore » department and program grew, so did the motivation to found an accelerator research center that brought experimentalists together in a test facility environment to conduct a broad range of experiments. The Final Focus Test Beam and later the Next Linear Collider Test Accelerator provided unique experimental facilities for AARD staff and collaborators to carry out advanced accelerator experiments. Throughout the evolution of this dynamic program, Bob maintained a department atmosphere and culture more reminiscent of a university research group than a national laboratory department. His exceptional ability to balance multiple roles as scientist, professor, and administrator enabled the creation and preservation of an environment that fostered technical innovation and scholarship.« less
1987-04-01
for two applications important to the development of charged particle beam propagation studies. The first application is to measure the decay of...at Los Alamos4 and the Medea accelerator at McDonnell- Douglas Research Laboratory.5 The second application is to measure the conductivity generated...for the first time. For slightly higher rep-rate accelerators such as Medea or PHERMEX, it will improve the accuracy of the results by eliminating pulse
Beam dynamics performances and applications of a low-energy electron-beam magnetic bunch compressor
DOE Office of Scientific and Technical Information (OSTI.GOV)
Prokop, C. R.; Piot, P.; Carlsten, B. E.
2013-08-01
Many front-end applications of electron linear accelerators rely on the production of temporally compressed bunches. The shortening of electron bunches is often realized with magnetic bunch compressors located in high-energy sections of accelerators. Magnetic compression is subject to collective effects including space charge and self interaction via coherent synchrotron radiation. In this paper we explore the application of magnetic compression to low-energy (~40MeV), high-charge (nC) electron bunches with low normalized transverse emittances (<5@mm).
Reduction of angular divergence of laser-driven ion beams during their acceleration and transport
NASA Astrophysics Data System (ADS)
Zakova, M.; Pšikal, Jan; Margarone, Daniele; Maggiore, Mario; Korn, G.
2015-05-01
Laser plasma physics is a field of big interest because of its implications in basic science, fast ignition, medicine (i.e. hadrontherapy), astrophysics, material science, particle acceleration etc. 100-MeV class protons accelerated from the interaction of a short laser pulse with a thin target have been demonstrated. With continuing development of laser technology, greater and greater energies are expected, therefore projects focusing on various applications are being formed, e.g. ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration). One of the main characteristic and crucial disadvantage of ion beams accelerated by ultra-short intense laser pulses is their large divergence, not suitable for the most of applications. In this paper two ways how to decrease beam divergence are proposed. Firstly, impact of different design of targets on beam divergence is studied by using 2D Particlein-cell simulations (PIC). Namely, various types of targets include at foils, curved foil and foils with diverse microstructures. Obtained results show that well-designed microstructures, i.e. a hole in the center of the target, can produce proton beam with the lowest divergence. Moreover, the particle beam accelerated from a curved foil has lower divergence compared to the beam from a flat foil. Secondly, another proposed method for the divergence reduction is using of a magnetic solenoid. The trajectories of the laser accelerated particles passing through the solenoid are modeled in a simple Matlab program. Results from PIC simulations are used as input in the program. The divergence is controlled by optimizing the magnetic field inside the solenoid and installing an aperture in front of the device.
NASA Astrophysics Data System (ADS)
Symon, Keith R.
2005-04-01
In the late 1950's and the 1960's the MURA (Midwestern Universities Research Association) working group developed fixed field alternating gradient (FFAG) particle accelerators. FFAG accelerators are a natural corollary of the invention of alternating gradient focusing. The fixed guide field accommodates all orbits from the injection to the final energy. For this reason, the transverse motion in the guide field is nearly decoupled from the longitudinal acceleration. This allows a wide variety of acceleration schemes, using betatron or rf accelerating fields, beam stacking, bucket lifts, phase displacement, etc. It also simplifies theoretical and experimental studies of accelerators. Theoretical studies included an extensive analysis of rf acceleration processes, nonlinear orbit dynamics, and collective instabilities. Two FFAG designs, radial sector and spiral sector, were invented. The MURA team built small electron models of each type, and used them to study orbit dynamics, acceleration processes, orbit instabilities, and space charge limits. A practical result of these studies was the invention of the spiral sector cyclotron. Another was beam stacking, which led to the first practical way of achieving colliding beams. A 50 MeV two-way radial sector model was built in which it proved possible to stack a beam of over 10 amperes of electrons.
Lemery, F.; Piot, P.
2015-08-03
Collinear high-gradient O(GV/m) beam-driven wakefield methods for charged-particle acceleration could be critical to the realization of compact, cost-efficient, accelerators, e.g., in support of TeV-scale lepton colliders or multiple-user free-electron laser facilities. To make these options viable, the high accelerating fields need to be complemented with large transformer ratios >2, a parameter characterizing the efficiency of the energy transfer between a wakefield-exciting “drive” bunch to an accelerated “witness” bunch. While several potential current distributions have been discussed, their practical realization appears challenging due to their often discontinuous nature. In this paper we propose several alternative continuously differentiable (smooth) current profiles whichmore » support enhanced transformer ratios. We especially demonstrate that one of the devised shapes can be implemented in a photo-emission electron source by properly shaping the photocathode-laser pulse. We finally discuss a possible superconducting linear-accelerator concept that could produce shaped drive bunches at high-repetition rates to drive a dielectric-wakefield accelerator with accelerating fields on the order of ~60 MV/m and a transformer ratio ~5 consistent with a recently proposed multiuser free-electron laser facility.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lemery, F.; Piot, P.
Collinear high-gradient O(GV/m) beam-driven wakefield methods for charged-particle acceleration could be critical to the realization of compact, cost-efficient, accelerators, e.g., in support of TeV-scale lepton colliders or multiple-user free-electron laser facilities. To make these options viable, the high accelerating fields need to be complemented with large transformer ratios >2, a parameter characterizing the efficiency of the energy transfer between a wakefield-exciting “drive” bunch to an accelerated “witness” bunch. While several potential current distributions have been discussed, their practical realization appears challenging due to their often discontinuous nature. In this paper we propose several alternative continuously differentiable (smooth) current profiles whichmore » support enhanced transformer ratios. We especially demonstrate that one of the devised shapes can be implemented in a photo-emission electron source by properly shaping the photocathode-laser pulse. We finally discuss a possible superconducting linear-accelerator concept that could produce shaped drive bunches at high-repetition rates to drive a dielectric-wakefield accelerator with accelerating fields on the order of ~60 MV/m and a transformer ratio ~5 consistent with a recently proposed multiuser free-electron laser facility.« less
Mechanism and preparation of liquid alkali-free liquid setting accelerator for shotcrete
NASA Astrophysics Data System (ADS)
Qiu, Ying; Ding, Bei; Gan, Jiezhong; Guo, Zhaolai; Zheng, Chunyang; Jiang, Haidong
2017-03-01
A new alkali-free liquid accelerator for shotcrete was prepared through normal temperature drop process by using the nano activated alumina and the modified alcohol amine as the main raw materials. The effect of alkali-free liquid accelerator on the cement setting time and the mechanical properties of mortar, the effect of the penetration strength on the shotcrete rebound were investigated. And the accelerating mechanism of the as-prepared alkali-free liquid accelerator was also analyzed via XRD and SEM characterization methods. The experimental results indicated that the hydration of C3A was accelerated by the polyamine complexation of accelerator, resulting in forming a large number of acicular ettringite and reducing the amount of Ca(OH)2 crystal, which would not affect the later hydration of cement. When the content of alkali-free liquid accelerator was 6%, the initial setting time and final setting time were less than 3min and 8min respectively, and 1d and 28d compressive strength ratios reached 207.6% and 114.2% respectively; beside that, the shotcrete rebound was very low because of the high penetration strength within 30min.
Compact RF ion source for industrial electrostatic ion accelerator
NASA Astrophysics Data System (ADS)
Kwon, Hyeok-Jung; Park, Sae-Hoon; Kim, Dae-Il; Cho, Yong-Sub
2016-02-01
Korea Multi-purpose Accelerator Complex is developing a single-ended electrostatic ion accelerator to irradiate gaseous ions, such as hydrogen and nitrogen, on materials for industrial applications. ELV type high voltage power supply has been selected. Because of the limited space, electrical power, and robust operation, a 200 MHz RF ion source has been developed. In this paper, the accelerator system, test stand of the ion source, and its test results are described.
Compact RF ion source for industrial electrostatic ion accelerator.
Kwon, Hyeok-Jung; Park, Sae-Hoon; Kim, Dae-Il; Cho, Yong-Sub
2016-02-01
Korea Multi-purpose Accelerator Complex is developing a single-ended electrostatic ion accelerator to irradiate gaseous ions, such as hydrogen and nitrogen, on materials for industrial applications. ELV type high voltage power supply has been selected. Because of the limited space, electrical power, and robust operation, a 200 MHz RF ion source has been developed. In this paper, the accelerator system, test stand of the ion source, and its test results are described.
Rail accelerators for space transportation: An experimental investigation
NASA Technical Reports Server (NTRS)
Zana, L. M.; Kerslake, W. R.; Sturman, J. L.
1986-01-01
An experimental program was conducted at the Lewis Research Center with the objective of investigating the technical feasibility of rail accelerators for propulsion applications. Single-stage, plasma driven rail accelerators of small (4 by 6 mm) and medium (12.5 by 12.5 mm) bores were tested at peak accelerating currents of 50 to 450 kA. Streak-camera photography was used to provide a qualitative description of plasma armature acceleration. The effects of plasma blowby and varying bore pressure on the behavior of plasma armatures were studied.
Dynamically Reconfigurable Systolic Array Accelerator
NASA Technical Reports Server (NTRS)
Dasu, Aravind; Barnes, Robert
2012-01-01
A polymorphic systolic array framework has been developed that works in conjunction with an embedded microprocessor on a field-programmable gate array (FPGA), which allows for dynamic and complimentary scaling of acceleration levels of two algorithms active concurrently on the FPGA. Use is made of systolic arrays and a hardware-software co-design to obtain an efficient multi-application acceleration system. The flexible and simple framework allows hosting of a broader range of algorithms, and is extendable to more complex applications in the area of aerospace embedded systems. FPGA chips can be responsive to realtime demands for changing applications needs, but only if the electronic fabric can respond fast enough. This systolic array framework allows for rapid partial and dynamic reconfiguration of the chip in response to the real-time needs of scalability, and adaptability of executables.
Radiation applications research and facilities in AECL research company
NASA Astrophysics Data System (ADS)
Iverson, S. L.
In the 60's and 70's Atomic Energy of Canada had a very active R&D program to discover and develop applications of ionizing radiation. Out of this grew the technology underlying the company's current product line of industrial irradiators. With the commercial success of that product line the company turned its R&D attention to other activities. Presently, widespread interest in the use of radiation for food processing and the possibility of developing reliable and competitive machine sources of radiation hold out the promise of a major increase in industrial use of radiation. While many of the applications being considered are straightforward applications of existing knowledge, others depend on more subtle effects including combined effects of two or more agents. Further research is required in these areas. In March 1985 a new branch, Radiation Applications Research, began operations with the objective of working closely with industry to develop and assist the introduction of new uses of ionizing radiation. The Branch is equipped with appropriate analytical equipment including HPLC (high performance liquid chromatograph) and GC/MS (gas chromatograph/mass spectrometer) as well as a Gammacell 220 and an I-10/1, one kilowatt 10 MeV electron accelerator. The accelerator is located in a specially designed facility equipped for experimental irradiation of test quantities of packaged products as well as solids, liquids and gases in various configurations. A conveyor system moves the packaged products from the receiving area, through a maze, past the electron beam at a controlled rate and finally to the shipping area. Other necessary capabilities, such as gamma and electron dosimetry and a microbiology laboratory, have also been developed. Initial projects in areas ranging from food through environmental and industrial applications have been assessed and the most promising have been selected for further work. As an example, the use of charcoal adsorbent beds to concentrate the components of gas or liquid waste streams requiring treatment is showing promise as a method of significantly reducing the cost of radiation treatment for some effluents. A number of other projects are described.
An Accelerated Release Method of Risperidone Loaded PLGA Microspheres with Good IVIVC.
Hu, Xiaoqin; Zhang, Jianwei; Tang, Xuemei; Li, Mingyuan; Ma, Siyu; Liu, Cheng; Gao, Yue; Zhang, Yue; Liu, Yan; Yu, Fanglin; Yang, Yang; Guo, Jia; Li, Zhiping; Mei, Xingguo
2018-01-01
A long release period lasting several days or several weeks is always needed and thereby it is tedious and time consuming to screen formulations of such microspheres with so long release period and evaluate their release profiles in vitro with conventional long-term or "real-time" release method. So, an accelerated release testing of such system is necessary for formulation design as well as quality control purpose. The purpose of this study is to obtain an accelerated release method of risperidone loaded poly(lactic-co-glycolic acid) (PLGA) microspheres with good in vitro/in vivo correlation (IVIVC). Two formulations of risperidone loaded PLGA microspheres used for evaluating IVIVC were prepared by O/W method. The accelerated release condition was optimized by investigating the effect of pH, osmotic pressure, temperature and ethanol concentration on the release of risperidone from microspheres and the in vitro accelerated release profiles of risperidone from PLGA microspheres were obtained under this optimized accelerated release condition. The plasma concentration of risperidone were also detected after subcutaneous injection of risperidone loaded microspheres to rats. The in vivo cumulative absorption profiles were then calculated using Wagner-Nelson model, Loo- Riegelman model and numerical convolution model, respectively. The correlation between in vitro accelerated release and in vivo cumulative absorption were finally evaluated with Least Square Method. It was shown that temperature and ethanol concentration significantly affected the release of risperidone from the microspheres while pH and osmotic pressure of release media slightly affected the release behavior of risperidone. The in vitro release of risperidone from microspheres were finally undergone in PBS (pH7.0, 300mosm) with 20% (V/V) ethanol at 45°C. The sustained and complete release of risperidone was observed in both formulations under the accelerated release condition although these two release profiles were dissimilar. The correlation coefficients (R2) of IVIVC were all above 0.95 and the slopes were all between 0.9564 and 1.1868 in spite of fitted model and microsphere formulation. An in vitro accelerated release method of risperidone microspheres with good IVIVC was established in this paper and this accelerated release method was supposed to have great potential in both in vivo performance prediction and quality control for risperidone loaded PLGA microspheres. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Acceleration of a trailing positron bunch in a plasma wakefield accelerator
Doche, A.; Beekman, C.; Corde, S.; ...
2017-10-27
High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation colliders. Here in these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positronmore » bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. Finally, the results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.« less
Acceleration of a trailing positron bunch in a plasma wakefield accelerator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Doche, A.; Beekman, C.; Corde, S.
High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation colliders. Here in these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positronmore » bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. Finally, the results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.« less
Self-shielded electron linear accelerators designed for radiation technologies
NASA Astrophysics Data System (ADS)
Belugin, V. M.; Rozanov, N. E.; Pirozhenko, V. M.
2009-09-01
This paper describes self-shielded high-intensity electron linear accelerators designed for radiation technologies. The specific property of the accelerators is that they do not apply an external magnetic field; acceleration and focusing of electron beams are performed by radio-frequency fields in the accelerating structures. The main characteristics of the accelerators are high current and beam power, but also reliable operation and a long service life. To obtain these characteristics, a number of problems have been solved, including a particular optimization of the accelerator components and the application of a variety of specific means. The paper describes features of the electron beam dynamics, accelerating structure, and radio-frequency power supply. Several compact self-shielded accelerators for radiation sterilization and x-ray cargo inspection have been created. The introduced methods made it possible to obtain a high intensity of the electron beam and good performance of the accelerators.
Prospects for Accelerator Technology
NASA Astrophysics Data System (ADS)
Todd, Alan
2011-02-01
Accelerator technology today is a greater than US$5 billion per annum business. Development of higher-performance technology with improved reliability that delivers reduced system size and life cycle cost is expected to significantly increase the total accelerator technology market and open up new application sales. Potential future directions are identified and pitfalls in new market penetration are considered. Both of the present big market segments, medical radiation therapy units and semiconductor ion implanters, are approaching the "maturity" phase of their product cycles, where incremental development rather than paradigm shifts is the norm, but they should continue to dominate commercial sales for some time. It is anticipated that large discovery-science accelerators will continue to provide a specialty market beset by the unpredictable cycles resulting from the scale of the projects themselves, coupled with external political and economic drivers. Although fraught with differing market entry difficulties, the security and environmental markets, together with new, as yet unrealized, industrial material processing applications, are expected to provide the bulk of future commercial accelerator technology growth.
Proton shock acceleration using a high contrast high intensity laser
NASA Astrophysics Data System (ADS)
Gauthier, Maxence; Roedel, Christian; Kim, Jongjin; Aurand, Bastian; Curry, Chandra; Goede, Sebastian; Propp, Adrienne; Goyon, Clement; Pak, Art; Kerr, Shaun; Ramakrishna, Bhuvanesh; Ruby, John; William, Jackson; Glenzer, Siegfried
2015-11-01
Laser-driven proton acceleration is a field of intense research due to the interesting characteristics of this novel particle source including high brightness, high maximum energy, high laminarity, and short duration. Although the ion beam characteristics are promising for many future applications, such as in the medical field or hybrid accelerators, the ion beam generated using TNSA, the acceleration mechanism commonly achieved, still need to be significantly improved. Several new alternative mechanisms have been proposed such as collisionless shock acceleration (CSA) in order to produce a mono-energetic ion beam favorable for those applications. We report the first results of an experiment performed with the TITAN laser system (JLF, LLNL) dedicated to the study of CSA using a high intensity (5x1019W/cm2) high contrast ps laser pulse focused on 55 μm thick CH and CD targets. We show that the proton spectrum generated during the interaction exhibits high-energy mono-energetic features along the laser axis, characteristic of a shock mechanism.
NONCOHERENT RADIATION DUE TO ELECTRONS IN A SYNCHROTRON AND SOME OF ITS APPLICATION (in Russian)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ado, Yu.M.
1963-01-01
Experiments are described in which the properties ot noncoherent radiation due to electrons accelerated in a synchrotron are investigated. The experiments were performed at the 280-Mev electron synchrotron of the Lebedeff Institute for Physics. An apparatus was constructed for the determination of optical radiation spectra arising from monoenergetic electrons during the complete acceleration cycle. The energy distribution of the radiation was determined for three electron energies, 150, 225, and 250 Mev. The intensity of various wvavelength radiation was measured as a function of the electron energy from 70 to 280 Mev. The effect of the intensity on the number ofmore » electrons was found to be linear for 250-Mev electrons. Three applications are described for the electron optical radiation: the determination of the number of accelerated electrons, the measurement of the amount of electrons hitting a target during the acceleration process, and the determination of the azimuthal extent of the clots of accelerated electrons. (TTT)« less
Programming and Runtime Support to Blaze FPGA Accelerator Deployment at Datacenter Scale
Huang, Muhuan; Wu, Di; Yu, Cody Hao; Fang, Zhenman; Interlandi, Matteo; Condie, Tyson; Cong, Jason
2017-01-01
With the end of CPU core scaling due to dark silicon limitations, customized accelerators on FPGAs have gained increased attention in modern datacenters due to their lower power, high performance and energy efficiency. Evidenced by Microsoft’s FPGA deployment in its Bing search engine and Intel’s 16.7 billion acquisition of Altera, integrating FPGAs into datacenters is considered one of the most promising approaches to sustain future datacenter growth. However, it is quite challenging for existing big data computing systems—like Apache Spark and Hadoop—to access the performance and energy benefits of FPGA accelerators. In this paper we design and implement Blaze to provide programming and runtime support for enabling easy and efficient deployments of FPGA accelerators in datacenters. In particular, Blaze abstracts FPGA accelerators as a service (FaaS) and provides a set of clean programming APIs for big data processing applications to easily utilize those accelerators. Our Blaze runtime implements an FaaS framework to efficiently share FPGA accelerators among multiple heterogeneous threads on a single node, and extends Hadoop YARN with accelerator-centric scheduling to efficiently share them among multiple computing tasks in the cluster. Experimental results using four representative big data applications demonstrate that Blaze greatly reduces the programming efforts to access FPGA accelerators in systems like Apache Spark and YARN, and improves the system throughput by 1.7 × to 3× (and energy efficiency by 1.5× to 2.7×) compared to a conventional CPU-only cluster. PMID:28317049
Programming and Runtime Support to Blaze FPGA Accelerator Deployment at Datacenter Scale.
Huang, Muhuan; Wu, Di; Yu, Cody Hao; Fang, Zhenman; Interlandi, Matteo; Condie, Tyson; Cong, Jason
2016-10-01
With the end of CPU core scaling due to dark silicon limitations, customized accelerators on FPGAs have gained increased attention in modern datacenters due to their lower power, high performance and energy efficiency. Evidenced by Microsoft's FPGA deployment in its Bing search engine and Intel's 16.7 billion acquisition of Altera, integrating FPGAs into datacenters is considered one of the most promising approaches to sustain future datacenter growth. However, it is quite challenging for existing big data computing systems-like Apache Spark and Hadoop-to access the performance and energy benefits of FPGA accelerators. In this paper we design and implement Blaze to provide programming and runtime support for enabling easy and efficient deployments of FPGA accelerators in datacenters. In particular, Blaze abstracts FPGA accelerators as a service (FaaS) and provides a set of clean programming APIs for big data processing applications to easily utilize those accelerators. Our Blaze runtime implements an FaaS framework to efficiently share FPGA accelerators among multiple heterogeneous threads on a single node, and extends Hadoop YARN with accelerator-centric scheduling to efficiently share them among multiple computing tasks in the cluster. Experimental results using four representative big data applications demonstrate that Blaze greatly reduces the programming efforts to access FPGA accelerators in systems like Apache Spark and YARN, and improves the system throughput by 1.7 × to 3× (and energy efficiency by 1.5× to 2.7×) compared to a conventional CPU-only cluster.
NASA Astrophysics Data System (ADS)
Pokorný, Jaroslav; Pavlíková, Milena; Medved, Igor; Pavlík, Zbyšek; Zahálková, Jana; Rovnaníková, Pavla; Černý, Robert
2016-06-01
Active silica containing materials in the sub-micrometer size range are commonly used for modification of strength parameters and durability of cement based composites. In addition, these materials also assist to accelerate cement hydration. In this paper, two types of diatomaceous earths are used as partial cement replacement in composition of cement paste mixtures. For raw binders, basic physical and chemical properties are studied. The chemical composition of tested materials is determined using classical chemical analysis combined with XRD method that allowed assessment of SiO2 amorphous phase content. For all tested mixtures, initial and final setting times are measured. Basic physical and mechanical properties are measured on hardened paste samples cured 28 days in water. Here, bulk density, matrix density, total open porosity, compressive and flexural strength, are measured. Relationship between compressive strength and total open porosity is studied using several empirical models. The obtained results give evidence of high pozzolanic activity of tested diatomite earths. Their application leads to the increase of both initial and final setting times, decrease of compressive strength, and increase of flexural strength.
Application of particle accelerators in research.
Mazzitelli, Giovanni
2011-07-01
Since the beginning of the past century, accelerators have started to play a fundamental role as powerful tools to discover the world around us, how the universe has evolved since the big bang and to develop fundamental instruments for everyday life. Although more than 15 000 accelerators are operating around the world only a very few of them are dedicated to fundamental research. An overview of the present high energy physics (HEP) accelerator status and prospectives is presented.
Kreiner, A J; Castell, W; Di Paolo, H; Baldo, M; Bergueiro, J; Burlon, A A; Cartelli, D; Vento, V Thatar; Kesque, J M; Erhardt, J; Ilardo, J C; Valda, A A; Debray, M E; Somacal, H R; Sandin, J C Suarez; Igarzabal, M; Huck, H; Estrada, L; Repetto, M; Obligado, M; Padulo, J; Minsky, D M; Herrera, M; Gonzalez, S J; Capoulat, M E
2011-12-01
We describe the present status of an ongoing project to develop a Tandem-ElectroStatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based (AB)-BNCT. The project final goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the (7)Li(p,n)(7)Be reaction. The machine currently being constructed is a folded TESQ with a high-voltage terminal at 0.6 MV. We report here on the progress achieved in a number of different areas. Copyright © 2011 Elsevier Ltd. All rights reserved.
Parallel processing approach to transform-based image coding
NASA Astrophysics Data System (ADS)
Normile, James O.; Wright, Dan; Chu, Ken; Yeh, Chia L.
1991-06-01
This paper describes a flexible parallel processing architecture designed for use in real time video processing. The system consists of floating point DSP processors connected to each other via fast serial links, each processor has access to a globally shared memory. A multiple bus architecture in combination with a dual ported memory allows communication with a host control processor. The system has been applied to prototyping of video compression and decompression algorithms. The decomposition of transform based algorithms for decompression into a form suitable for parallel processing is described. A technique for automatic load balancing among the processors is developed and discussed, results ar presented with image statistics and data rates. Finally techniques for accelerating the system throughput are analyzed and results from the application of one such modification described.
A GPU-paralleled implementation of an enhanced face recognition algorithm
NASA Astrophysics Data System (ADS)
Chen, Hao; Liu, Xiyang; Shao, Shuai; Zan, Jiguo
2013-03-01
Face recognition algorithm based on compressed sensing and sparse representation is hotly argued in these years. The scheme of this algorithm increases recognition rate as well as anti-noise capability. However, the computational cost is expensive and has become a main restricting factor for real world applications. In this paper, we introduce a GPU-accelerated hybrid variant of face recognition algorithm named parallel face recognition algorithm (pFRA). We describe here how to carry out parallel optimization design to take full advantage of many-core structure of a GPU. The pFRA is tested and compared with several other implementations under different data sample size. Finally, Our pFRA, implemented with NVIDIA GPU and Computer Unified Device Architecture (CUDA) programming model, achieves a significant speedup over the traditional CPU implementations.
Chen, Qian-Qian; Hou, Chun-Chao; Wang, Chuan-Jun; Yang, Xiao; Shi, Rui; Chen, Yong
2018-06-06
NiFe-layered double hydroxide (NiFe LDH) is a state-of-the-art oxygen evolution reaction (OER) electrocatalyst, yet it suffers from rather poor catalytic activity for the hydrogen evolution reaction (HER) due to its extremely sluggish water dissociation kinetics, severely restricting its application in overall water splitting. Herein, we report a novel strategy to expedite the HER kinetics of NiFe LDH by an Ir4+-doping strategy to accelerate the water dissociation process (Volmer step), and thus this catalyst exhibits superior and robust catalytic activity for finally oriented overall water splitting in 1 M KOH requiring only a low initial voltage of 1.41 V delivering at 20 mA cm-2 for more than 50 h.
Speeding up GW Calculations to Meet the Challenge of Large Scale Quasiparticle Predictions.
Gao, Weiwei; Xia, Weiyi; Gao, Xiang; Zhang, Peihong
2016-11-11
Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged GW calculations for large systems, enabling fast and accurate quasiparticle calculations for complex materials systems. We demonstrate the performance of this new method by presenting the results for ZnO and MgO supercells. A speed-up factor of nearly two orders of magnitude is achieved for a system containing 256 atoms (1024 valence electrons) with a negligibly small numerical error of ±0.03 eV. Finally, we discuss the application of our method to the GW calculations for 2D materials.
Time of Flight based diagnostics for high energy laser driven ion beams
NASA Astrophysics Data System (ADS)
Scuderi, V.; Milluzzo, G.; Alejo, A.; Amico, A. G.; Booth, N.; Cirrone, G. A. P.; Doria, D.; Green, J.; Kar, S.; Larosa, G.; Leanza, R.; Margarone, D.; McKenna, P.; Padda, H.; Petringa, G.; Pipek, J.; Romagnani, L.; Romano, F.; Schillaci, F.; Borghesi, M.; Cuttone, G.; Korn, G.
2017-03-01
Nowadays the innovative high power laser-based ion acceleration technique is one of the most interesting challenges in particle acceleration field, showing attractive characteristics for future multidisciplinary applications, including medical ones. Nevertheless, peculiarities of optically accelerated ion beams make mandatory the development of proper transport, selection and diagnostics devices in order to deliver stable and controlled ion beams for multidisciplinary applications. This is the main purpose of the ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) beamline that will be realized and installed within 2018 at the ELI-Beamlines research center in the Czech Republic, where laser driven high energy ions, up to 60 MeV/n, will be available for users. In particular, a crucial role will be played by the on-line diagnostics system, recently developed in collaboration with INFN-LNS (Italy), consisting of TOF detectors, placed along the beamline (at different detection distances) to provide online monitoring of key characteristics of delivered beams, such as energy, fluence and ion species. In this contribution an overview on the ELIMAIA available ion diagnostics will be briefly given along with the preliminary results obtained during a test performed with high energy laser-driven proton beams accelerated at the VULCAN PW-laser available at RAL facility (U.K.).
Underbody Blast Models of TBI Caused by Hyper-Acceleration and Secondary Head Impact
2016-02-01
discovery rate (FDR), which controls for the expected proportion of false rejected hypotheses. ANOVA was performed to evaluate the significance in gene...acceleration/deceleration11,27 and blast4,13 have also been designed for the purpose of evaluating coup-contrecoup and blast wave energies potentially... evaluation of different angles/ locations of the projectile impact to the surface of the rat head. Finally, pilot studies were conducted to provide further
DOE Office of Scientific and Technical Information (OSTI.GOV)
Albright, Brian James; Yin, Lin; Stark, David James
This proposal sought of order 1M core-hours of Institutional Computing time intended to enable computing by a new LANL Postdoc (David Stark) working under LDRD ER project 20160472ER (PI: Lin Yin) on laser-ion acceleration. The project was “off-cycle,” initiating in June of 2016 with a postdoc hire.
TM 4: Beam through the Main Linac Cryomodule
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bartnik, A.
2017-06-14
On May 15th 2017, the CBETA project reached the major funding milestone, “Beam through the MLC.” For this test, the team had to successfully accelerate the electron beam to 6 MeV in the Injector Cryomodule (ICM), and then to a final energy of 12 MeV in the Main Linac Cryomodule (MLC). The MLC contains six superconducting accelerating cavities; for this initial test only a single cavity was powered.
Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157.
Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka; Boban-Blagaic, Alenka; Zoric, Zdenka; Ivanovic, Domagoj; Ajduk, Marko; Sebecic, Bozidar; Patrlj, Leonardo; Sosa, Tomislav; Buljat, Gojko; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag
2006-05-01
We report complete transection of major muscle and the systemic peptide treatment that induces healing of quadriceps muscle promptly and then maintains the healing with functional restoration. Initially, stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, PL-10, PLD-116, PL 14736 Pliva, Croatia; in trials for inflammatory bowel disease; wound treatment; no toxicity reported; effective alone without carrier) also superiorly accelerates the healing of transected Achilles tendon. Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat. BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice. It consistently improves muscle healing throughout the whole 72-day period. Improved are: (i) biomechanic (load of failure increased); (ii) function (walking recovery and extensor postural thrust/motor function index returned toward normal healthy values); (iii) microscopy/immunochemistry [i.e., mostly muscle fibers connect muscle segments; absent gap; significant desmin positivity for ongoing regeneration of muscle; larger myofibril diameters on both sides, distal and proximal (normal healthy rat-values reached)]; (iv) macroscopic presentation (stumps connected; subsequently, atrophy markedly attenuated; finally, presentation close to normal noninjured muscle, no postsurgery leg contracture). Thus, posttransection healing-consistently improved-may suggest this peptide therapeutic application in muscle disorders. Copyright 2006 Orthopaedic Research Society.
NASA Technical Reports Server (NTRS)
Canacci, Victor A.; Braun, M. Jack
1994-01-01
The experimental approach presented here offers a nonintrusive, qualitative and quantitative evaluation of full field flow patterns applicable in various geometries in a variety of fluids. This Full Flow Field Tracking (FFFT) Particle Image Velocimetry (PIV) technique, by means of particle tracers illuminated by a laser light sheet, offers an alternative to Laser Doppler Velocimetry (LDV), and intrusive systems such as Hot Wire/Film Anemometry. The method makes obtainable the flow patterns, and allows quantitative determination of the velocities, accelerations, and mass flows of an entire flow field. The method uses a computer based digitizing system attached through an imaging board to a low luminosity camera. A customized optical train allows the system to become a long distance microscope (LDM), allowing magnifications of areas of interest ranging up to 100 times. Presented in addition to the method itself, are studies in which the flow patterns and velocities were observed and evaluated in three distinct geometries, with three different working fluids. The first study involved pressure and flow analysis of a brush seal in oil. The next application involved studying the velocity and flow patterns in a cowl lip cooling passage of an air breathing aircraft engine using water as the working fluid. Finally, the method was extended to a study in air to examine the flows in a staggered pin arrangement located on one side of a branched duct.
2014-01-01
A specially designed sensor processor used as a main processor in IoT (internet-of-thing) device for the rare-event sensing applications is proposed. The IoT device including the proposed sensor processor performs the event-driven sensor data processing based on an accuracy-energy configurable event-quantization in architectural level. The received sensor signal is converted into a sequence of atomic events, which is extracted by the signal-to-atomic-event generator (AEG). Using an event signal processing unit (EPU) as an accelerator, the extracted atomic events are analyzed to build the final event. Instead of the sampled raw data transmission via internet, the proposed method delays the communication with a host system until a semantic pattern of the signal is identified as a final event. The proposed processor is implemented on a single chip, which is tightly coupled in bus connection level with a microcontroller using a 0.18 μm CMOS embedded-flash process. For experimental results, we evaluated the proposed sensor processor by using an IR- (infrared radio-) based signal reflection and sensor signal acquisition system. We successfully demonstrated that the expected power consumption is in the range of 20% to 50% compared to the result of the basement in case of allowing 10% accuracy error. PMID:25580458
An investigation of two phase flow pressure drops in a reduced acceleration environment
NASA Astrophysics Data System (ADS)
Wheeler, Montgomery W.; Best, Frederick R.; Reinarts, Thomas R.
1993-01-01
Thermal systems for space applications based on two phase flow have several advantages over single phase systems. Two phase thermal energy management and dynamic power conversion system advantages include the capability of achieving high specific power levels. Before two phase systems for space applications can be designed effectively, knowledge of the flow behavior in a reduced acceleration environment is necessary. To meet these needs, two phase flow experiments were conducted aboard the National Aeronautic and Space Administration's KC-135 using R12 as the working fluid. Annular flow two phase pressure drops were measured through 10.41-mm ID 1.251-m long glass tubing during periods with acceleration levels in the range ±0.05 G. The experiments were conducted with emphasis on achieving data with a high level of accuracy. The reduced acceleration annular flow pressure drops were compred with pressure drops measured in a 1-G environment for similar flow conditions. The reduced acceleration pressure drops were found to be 45% greater than the 1-G pressure drops. In addition, the reduced acceleration annular flow interfacial friction factors were compared with models for vertical up-flow in a 1-G environment. The reduced acceleration interfacial friction factor data was not predicted by the 1-G models.
MEMS-based, RF-driven, compact accelerators
NASA Astrophysics Data System (ADS)
Persaud, A.; Seidl, P. A.; Ji, Q.; Breinyn, I.; Waldron, W. L.; Schenkel, T.; Vinayakumar, K. B.; Ni, D.; Lal, A.
2017-10-01
Shrinking existing accelerators in size can reduce their cost by orders of magnitude. Furthermore, by using radio frequency (RF) technology and accelerating ions in several stages, the applied voltages can be kept low paving the way to new ion beam applications. We make use of the concept of a Multiple Electrostatic Quadrupole Array Linear Accelerator (MEQALAC) and have previously shown the implementation of its basic components using printed circuit boards, thereby reducing the size of earlier MEQALACs by an order of magnitude. We now demonstrate the combined integration of these components to form a basic accelerator structure, including an initial beam-matching section. In this presentation, we will discuss the results from the integrated multi-beam ion accelerator and also ion acceleration using RF voltages generated on-board. Furthermore, we will show results from Micro-Electro-Mechanical Systems (MEMS) fabricated focusing wafers, which can shrink the dimension of the system to the sub-mm regime and lead to cheaper fabrication. Based on these proof-of-concept results we outline a scaling path to high beam power for applications in plasma heating in magnetized target fusion and in neutral beam injectors for future Tokamaks. This work was supported by the Office of Science of the US Department of Energy through the ARPA-e ALPHA program under contracts DE-AC02-05CH11231.
Seismic signal processing on heterogeneous supercomputers
NASA Astrophysics Data System (ADS)
Gokhberg, Alexey; Ermert, Laura; Fichtner, Andreas
2015-04-01
The processing of seismic signals - including the correlation of massive ambient noise data sets - represents an important part of a wide range of seismological applications. It is characterized by large data volumes as well as high computational input/output intensity. Development of efficient approaches towards seismic signal processing on emerging high performance computing systems is therefore essential. Heterogeneous supercomputing systems introduced in the recent years provide numerous computing nodes interconnected via high throughput networks, every node containing a mix of processing elements of different architectures, like several sequential processor cores and one or a few graphical processing units (GPU) serving as accelerators. A typical representative of such computing systems is "Piz Daint", a supercomputer of the Cray XC 30 family operated by the Swiss National Supercomputing Center (CSCS), which we used in this research. Heterogeneous supercomputers provide an opportunity for manifold application performance increase and are more energy-efficient, however they have much higher hardware complexity and are therefore much more difficult to program. The programming effort may be substantially reduced by the introduction of modular libraries of software components that can be reused for a wide class of seismology applications. The ultimate goal of this research is design of a prototype for such library suitable for implementing various seismic signal processing applications on heterogeneous systems. As a representative use case we have chosen an ambient noise correlation application. Ambient noise interferometry has developed into one of the most powerful tools to image and monitor the Earth's interior. Future applications will require the extraction of increasingly small details from noise recordings. To meet this demand, more advanced correlation techniques combined with very large data volumes are needed. This poses new computational problems that require dedicated HPC solutions. The chosen application is using a wide range of common signal processing methods, which include various IIR filter designs, amplitude and phase correlation, computing the analytic signal, and discrete Fourier transforms. Furthermore, various processing methods specific for seismology, like rotation of seismic traces, are used. Efficient implementation of all these methods on the GPU-accelerated systems represents several challenges. In particular, it requires a careful distribution of work between the sequential processors and accelerators. Furthermore, since the application is designed to process very large volumes of data, special attention had to be paid to the efficient use of the available memory and networking hardware resources in order to reduce intensity of data input and output. In our contribution we will explain the software architecture as well as principal engineering decisions used to address these challenges. We will also describe the programming model based on C++ and CUDA that we used to develop the software. Finally, we will demonstrate performance improvements achieved by using the heterogeneous computing architecture. This work was supported by a grant from the Swiss National Supercomputing Centre (CSCS) under project ID d26.
Foil Bearing Starting Considerations and Requirements for Rotorcraft Engine Applications
NASA Technical Reports Server (NTRS)
Radil, Kevin C.; DellaCorte, Christopher
2009-01-01
Foil gas bearings under development for rotorcraft-sized, hot core engine applications have been susceptible to damage from the slow acceleration and rates typically encountered during the pre-ignition stage in conventional engines. Recent laboratory failures have been assumed to be directly linked to operating foil bearings below their lift-off speed while following conventional startup procedures for the engines. In each instance, the continuous sliding contact between the foils and shaft was believed to thermally overload the bearing and cause the engines to fail. These failures highlight the need to characterize required acceleration rates and minimum operating speeds for these applications. In this report, startup experiments were conducted with a large, rotorcraft engine sized foil bearing under moderate load and acceleration rates to identify the proper start procedures needed to avoid bearing failure. The results showed that a bearing under a 39.4 kPa static load can withstand a modest acceleration rate of 500 rpm/s and excessive loitering below the bearing lift-off speed provided an adequate solid lubricant is present.
Nb3Sn SRF Cavities for Nuclear Physics Applications
NASA Astrophysics Data System (ADS)
Eremeev, Grigory
2017-01-01
Nuclear physics experiments rely increasingly on accelerators, which employ superconducting RF (SRF) technology. CEBAF, SNS, FRIB, ESS, among others exploit the low surface resistance of SRF cavities to efficiently accelerate particle beams towards experimental targets. Niobium is the cavity material of choice for all current or planned SRF accelerators, but it has been long recognized that other superconductors with high superconducting transition temperatures have the potential to surpass niobium for SRF applications. Among the alternatives, Nb3Sn coated cavities are the most advanced on the path to practical applications: Nb3Sn coatings on R&D cavities have Tc consistently close the optimal 18 K, very low RF surface resistances, and very recently were shown to reach above Hc1 without anomalous RF surface resistance increase. In my talk I will discuss the prospects of Nb3Sn SRF cavities, the research efforts to realize Nb3Sn coatings on practical multi-cell accelerating structures, and the path toward possible inclusion in CEBAF. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics.
DeepX: Deep Learning Accelerator for Restricted Boltzmann Machine Artificial Neural Networks.
Kim, Lok-Won
2018-05-01
Although there have been many decades of research and commercial presence on high performance general purpose processors, there are still many applications that require fully customized hardware architectures for further computational acceleration. Recently, deep learning has been successfully used to learn in a wide variety of applications, but their heavy computation demand has considerably limited their practical applications. This paper proposes a fully pipelined acceleration architecture to alleviate high computational demand of an artificial neural network (ANN) which is restricted Boltzmann machine (RBM) ANNs. The implemented RBM ANN accelerator (integrating network size, using 128 input cases per batch, and running at a 303-MHz clock frequency) integrated in a state-of-the art field-programmable gate array (FPGA) (Xilinx Virtex 7 XC7V-2000T) provides a computational performance of 301-billion connection-updates-per-second and about 193 times higher performance than a software solution running on general purpose processors. Most importantly, the architecture enables over 4 times (12 times in batch learning) higher performance compared with a previous work when both are implemented in an FPGA device (XC2VP70).
NASA Astrophysics Data System (ADS)
Combs, S. K.; Milora, S. L.; Foust, C. R.; Gouge, M. J.; Fehling, D. T.; Sparks, D. O.
1988-08-01
The development of a two-stage light gas gun to accelerate hydrogen isotope pellets to high speeds is under way at Oak Ridge National Laboratory. High velocities are desirable for plasma fueling applications, since the faster pellets can penetrate more deeply into large, hot plasmas and deposit atoms of fuel directly in a larger fraction of the plasma volume. In the initial configuration of the two-stage device, a 2.2-l volume provides the gas to accelerate a 25.4-mm-diam piston in a 1-m-long pump tube; a burst disk or a fast valve initiates the acceleration process in the first stage. As the piston travels the length of the pump tube, the downstream gas is compressed (to pressures up to 2600 bar) and thus is driven to high temperature (approx. 5000 K). This provides the driving force for acceleration of a 4-mm pellet in a 1-m-long gun barrel. In preliminary tests using helium as the driver in both stages, 35-mg plastic pellets have been accelerated to speeds as high as 3.8 km/s. Projectiles composed of hydrogen ice will have a mass in the range from 5 to 20 mg. However, the use of sabots to encase and protect the cryogenic pellets from the high peak pressures will probably be required to realize speeds of approx. 3 km/s or greater. The experimental plan includes acceleration of hydrogen isotopes as soon as the gun geometry and operating parameters are optimized; theoretical models are being used to aid in this process. The hardware is being designed to accommodate repetitive operation, which is the objective of this research and is required for future applications.
Beam dynamics issues in linear colliders
DOE Office of Scientific and Technical Information (OSTI.GOV)
Seeman, J.T.
1989-06-01
The primary goal of present and future linear colliders is to maximize the integrated luminosity for the experimental program. Beam dynamics plays a central role in the maximization of integrated luminosity. It is the major issue in the production of small beam sizes and low experimental backgrounds and is also an important factor in the production of particle numbers, in the acceleration process, and in the number of bunches. The beam dynamics effects on bunches which are extracted from the damping rings, accelerated in the linac, collimated, momentum analyzed, and finally delivered to the final focus are reviewed. The effectsmore » of bunch compression, transverse and longitudinal wakefields, BNS damping, energy definition, dispersion, emittance, bunch aspect ratio, feedback, and stability are all important. 11 refs., 1 tab.« less
Miniature penetrator (MinPen) acceleration recorder development test
DOE Office of Scientific and Technical Information (OSTI.GOV)
Franco, R.J.; Platzbecker, M.R.
1998-08-01
The Telemetry Technology Development Department at Sandia National Laboratories actively develops and tests acceleration recorders for penetrating weapons. This new acceleration recorder (MinPen) utilizes a microprocessor-based architecture for operational flexibility while maintaining electronics and packaging techniques developed over years of penetrator testing. MinPen has been demonstrated to function in shock environments up to 20,000 Gs. The MinPen instrumentation development has resulted in a rugged, versatile, miniature acceleration recorder and is a valuable tool for penetrator testing in a wide range of applications.
Cosmic-ray shock acceleration in oblique MHD shocks
NASA Technical Reports Server (NTRS)
Webb, G. M.; Drury, L. OC.; Volk, H. J.
1986-01-01
A one-dimensional, steady-state hydrodynamical model of cosmic-ray acceleration at oblique MHD shocks is presented. Upstream of the shock the incoming thermal plasma is subject to the adverse pressure gradient of the accelerated particles, the J x B force, as well as the thermal gas pressure gradient. The efficiency of the acceleration of cosmic-rays at the shock as a function of the upstream magnetic field obliquity and upstream plasma beta is investigated. Astrophysical applications of the results are briefly discussed.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Friedman, A.; Barnard, J.J.; Briggs, R.J.
The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaborationof LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity"tilt" to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of Warm Dense Matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven Inertial Fusion Energy (IFE). Thesemore » goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned Advanced Test Accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates a ~;;30 nC pulse of Li+ ions to ~;;3 MeV, then compresses it to ~;;1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using analysis, an interactive one-dimensional kinetic simulation model, and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described.« less
Identifying regional opportunities for accelerated timber managemnet
David A. Gansner; Joseph E. Barnard; Samuel F. Gingrich; Samuel F. Gingrich
1973-01-01
Describes a procedure for identifying regional opportunities for accelerated timber management and demonstrates its application. Results provide a basis for rational choices among alternative management strategies and permit meaningful micro- and macro-evaluations of treatment response.
Hardware accelerator of convolution with exponential function for image processing applications
NASA Astrophysics Data System (ADS)
Panchenko, Ivan; Bucha, Victor
2015-12-01
In this paper we describe a Hardware Accelerator (HWA) for fast recursive approximation of separable convolution with exponential function. This filter can be used in many Image Processing (IP) applications, e.g. depth-dependent image blur, image enhancement and disparity estimation. We have adopted this filter RTL implementation to provide maximum throughput in constrains of required memory bandwidth and hardware resources to provide a power-efficient VLSI implementation.
Accelerated weathering of fire-retardant-treated wood for fire testing
Robert H. White
2009-01-01
Fire-retardant-treated products for exterior applications must be subjected to actual or accelerated weathering prior to fire testing. For fire-retardant-treated wood, the two accelerated weathering methods have been Method A and B of ASTM D 2898. The rain test is Method A of ASTM D 2898. Method B includes exposures to ultraviolet (UV) sunlamps in addition to water...
ERIC Educational Resources Information Center
Anzivino, Barbara; Tilley, Leon J.; Ingalls, Laura R.; Hall, Adam B.; Drugan, John E.
2009-01-01
An undergraduate organic chemistry experiment demonstrating real-life application of GC-MS to arson accelerant identification is described. Students are given the task of comparing a sample recovered from a "crime scene" to that from a "suspect's clothing". Accelerants subjected to different conditions are recovered using a quick and simple…
Convergence acceleration of viscous flow computations
NASA Technical Reports Server (NTRS)
Johnson, G. M.
1982-01-01
A multiple-grid convergence acceleration technique introduced for application to the solution of the Euler equations by means of Lax-Wendroff algorithms is extended to treat compressible viscous flow. Computational results are presented for the solution of the thin-layer version of the Navier-Stokes equations using the explicit MacCormack algorithm, accelerated by a convective coarse-grid scheme. Extensions and generalizations are mentioned.
Andreani, C.; Anderson, I. S.; Carpenter, J. M.; ...
2014-12-24
In 2005 the International Atomic Energy Agency (IAEA) in Vienna published a report [1] on ‘Development Opportunities of Small and Medium Scale Accelerator Driven Neutron Sources’ which summarized the prospect of smaller sources in supporting the large spallation neutron sources for materials characterization and instrumentation, a theme advocated by Bauer, Clausen, Mank, and Mulhauser in previous publications [2-4]. In 2010 the Union for Compact Accelerator-driven Neutron Sources (UCANS) was established [5], galvanizing cross-disciplinary collaborations on new source and neutronics development and expanded applications based on both slow-neutron scattering and other neutron-matter interactions of neutron energies ranging from 10⁻⁶ to 10²more » MeV [6]. Here, we first cover the recent development of ongoing and prospective projects of compact accelerator-driven neutron sources (CANS) but concentrate on prospective accelerators currently proposed in Italy. Two active R&D topics, irradiation effects on electronics and cultural heritage studies, are chosen to illustrate the impact of state-of-the-art CANS on these programs with respect to the characteristics and complementarity of the accelerator and neutronics systems as well as instrumentation development.« less
Muon Acceleration Concepts for NuMAX: "Dual-use" Linac and "Dogbone" RLA
Bogacz, S. A.
2018-02-01
In this paper, we summarize the current state of a concept for muon acceleration aimed at a future Neutrino Factory. The main thrust of these studies was to reduce the overall cost while maintaining performance by exploring the interplay between the complexity of the cooling systems and the acceptance of the accelerator complex. To ensure adequate survival for the short-lived muons, acceleration must occur at high average gradient. The need for large transverse and longitudinal acceptances drives the design of the acceleration system to an initially low RF frequency, e.g., 325 MHz, which is then increased to 650 MHz asmore » the transverse size shrinks with increasing energy. High-gradient normal conducting RF cavities at these frequencies require extremely high peak-power RF sources. Hence superconducting RF (SRF) cavities are chosen. Finally, we consider two cost effective schemes for accelerating muon beams for a stageable Neutrino Factory: exploration of the so-called "dual-use" linac concept, where the same linac structure is used for acceleration of both H - and muons and, alternatively, an SRF-efficient design based on a multi-pass (4.5) "dogbone" RLA, extendable to multi-pass FFAG-like arcs.« less
Dynamics of temporal variations in phonatory flow.
Krane, Michael H; Barry, Michael; Wei, Timothy
2010-07-01
This paper addresses the dynamic relevance of time variations of phonatory airflow, commonly neglected under the quasisteady phonatory flow assumption. In contrast to previous efforts, which relied on direct measurement of glottal impedance, this work uses spatially and temporally resolved measurements of the velocity field to estimate the unsteady and convective acceleration terms in the unsteady Bernoulli equation. Theoretical considerations suggest that phonatory flow is inherently unsteady when two related conditions apply: (1) that the unsteady and convective accelerations are commensurate, and (2) that the inertia of the glottal jet is non-negligible. Acceleration waveforms, computed from experimental data, show that unsteady and convective accelerations to be the same order of magnitude, throughout the cycle, and that the jet flow contributes significantly to the unsteady acceleration. In the middle of the cycle, however, jet inertia is negligible because the convective and unsteady accelerations nearly offset one another in the jet region. These results, consistent with previous findings treating quasisteady phonatory flow, emphasize that unsteady acceleration cannot be neglected during the final stages of the phonation cycle, during which voice sound power and spectral content are largely determined. Furthermore, glottal jet dynamics must be included in any model of phonatory airflow.
Dynamics of temporal variations in phonatory flow1
Krane, Michael H.; Barry, Michael; Wei, Timothy
2010-01-01
This paper addresses the dynamic relevance of time variations of phonatory airflow, commonly neglected under the quasisteady phonatory flow assumption. In contrast to previous efforts, which relied on direct measurement of glottal impedance, this work uses spatially and temporally resolved measurements of the velocity field to estimate the unsteady and convective acceleration terms in the unsteady Bernoulli equation. Theoretical considerations suggest that phonatory flow is inherently unsteady when two related conditions apply: (1) that the unsteady and convective accelerations are commensurate, and (2) that the inertia of the glottal jet is non-negligible. Acceleration waveforms, computed from experimental data, show that unsteady and convective accelerations to be the same order of magnitude, throughout the cycle, and that the jet flow contributes significantly to the unsteady acceleration. In the middle of the cycle, however, jet inertia is negligible because the convective and unsteady accelerations nearly offset one another in the jet region. These results, consistent with previous findings treating quasisteady phonatory flow, emphasize that unsteady acceleration cannot be neglected during the final stages of the phonation cycle, during which voice sound power and spectral content are largely determined. Furthermore, glottal jet dynamics must be included in any model of phonatory airflow. PMID:20649231
Xu, Daguang; Huang, Yong; Kang, Jin U
2014-06-16
We implemented the graphics processing unit (GPU) accelerated compressive sensing (CS) non-uniform in k-space spectral domain optical coherence tomography (SD OCT). Kaiser-Bessel (KB) function and Gaussian function are used independently as the convolution kernel in the gridding-based non-uniform fast Fourier transform (NUFFT) algorithm with different oversampling ratios and kernel widths. Our implementation is compared with the GPU-accelerated modified non-uniform discrete Fourier transform (MNUDFT) matrix-based CS SD OCT and the GPU-accelerated fast Fourier transform (FFT)-based CS SD OCT. It was found that our implementation has comparable performance to the GPU-accelerated MNUDFT-based CS SD OCT in terms of image quality while providing more than 5 times speed enhancement. When compared to the GPU-accelerated FFT based-CS SD OCT, it shows smaller background noise and less side lobes while eliminating the need for the cumbersome k-space grid filling and the k-linear calibration procedure. Finally, we demonstrated that by using a conventional desktop computer architecture having three GPUs, real-time B-mode imaging can be obtained in excess of 30 fps for the GPU-accelerated NUFFT based CS SD OCT with frame size 2048(axial) × 1,000(lateral).
Dusty-Plasma Particle Accelerator
NASA Technical Reports Server (NTRS)
Foster, John E.
2005-01-01
A dusty-plasma apparatus is being investigated as means of accelerating nanometer- and micrometer-sized particles. Applications for the dusty-plasma particle accelerators fall into two classes: Simulation of a variety of rapidly moving dust particles and micrometeoroids in outer-space environments that include micrometeoroid streams, comet tails, planetary rings, and nebulae and Deposition or implantation of nanoparticles on substrates for diverse industrial purposes that could include hardening, increasing thermal insulation, altering optical properties, and/or increasing permittivities of substrate materials. Relative to prior apparatuses used for similar applications, dusty-plasma particle accelerators offer such potential advantages as smaller size, lower cost, less complexity, and increased particle flux densities. A dusty-plasma particle accelerator exploits the fact that an isolated particle immersed in plasma acquires a net electric charge that depends on the relative mobilities of electrons and ions. Typically, a particle that is immersed in a low-temperature, partially ionized gas, wherein the average kinetic energy of electrons exceeds that of ions, causes the particle to become negatively charged. The particle can then be accelerated by applying an appropriate electric field. A dusty-plasma particle accelerator (see figure) includes a plasma source such as a radio-frequency induction discharge apparatus containing (1) a shallow cup with a biasable electrode to hold the particles to be accelerated and (2) a holder for the substrate on which the particles are to impinge. Depending on the specific design, a pair of electrostatic-acceleration grids between the substrate and discharge plasma can be used to both collimate and further accelerate particles exiting the particle holder. Once exposed to the discharge plasma, the particles in the cup quickly acquire a negative charge. Application of a negative voltage pulse to the biasable electrode results in the initiation of a low-current, high-voltage cathode spot. Plasma pressure associated with the cathode spot as well as the large voltage drop at the cathode spot accelerates the charged particles toward the substrate. The ultimate kinetic energy attained by particles exiting the particle holder depends in part on the magnitude of the cathode spot sheath potential difference, which is proportional to the magnitude of the voltage pulse, and the on the electric charge on the dust. The magnitude of the voltage pulse can be controlled directly, whereas the particle s electric charge can be controlled indirectly by controlling the operating parameters of the plasma apparatus.
Applications of the Electrodynamic Tether to Interstellar Travel
NASA Technical Reports Server (NTRS)
Matloff, Gregory L.; Johnson, Les
2005-01-01
After considering relevant properties of the local interstellar medium and defining a sample interstellar mission, this paper considers possible interstellar applications of the electrodynamic tether, or EDT. These include use of the EDT to provide on-board power and affect trajectory modifications and direct application of the EDT to starship acceleration. It is demonstrated that comparatively modest EDTs can provide substantial quantities of on-board power, if combined with a large-area electron-collection device such as the Cassenti toroidal-field ramscoop. More substantial tethers can be used to accomplish large-radius thrustless turns. Direct application of the EDT to starship acceleration is apparently infeasible.
Particle acceleration at a reconnecting magnetic separator
NASA Astrophysics Data System (ADS)
Threlfall, J.; Neukirch, T.; Parnell, C. E.; Eradat Oskoui, S.
2015-02-01
Context. While the exact acceleration mechanism of energetic particles during solar flares is (as yet) unknown, magnetic reconnection plays a key role both in the release of stored magnetic energy of the solar corona and the magnetic restructuring during a flare. Recent work has shown that special field lines, called separators, are common sites of reconnection in 3D numerical experiments. To date, 3D separator reconnection sites have received little attention as particle accelerators. Aims: We investigate the effectiveness of separator reconnection as a particle acceleration mechanism for electrons and protons. Methods: We study the particle acceleration using a relativistic guiding-centre particle code in a time-dependent kinematic model of magnetic reconnection at a separator. Results: The effect upon particle behaviour of initial position, pitch angle, and initial kinetic energy are examined in detail, both for specific (single) particle examples and for large distributions of initial conditions. The separator reconnection model contains several free parameters, and we study the effect of changing these parameters upon particle acceleration, in particular in view of the final particle energy ranges that agree with observed energy spectra.
The Impact of Accelerating Faster than Exponential Population Growth on Genetic Variation
Reppell, Mark; Boehnke, Michael; Zöllner, Sebastian
2014-01-01
Current human sequencing projects observe an abundance of extremely rare genetic variation, suggesting recent acceleration of population growth. To better understand the impact of such accelerating growth on the quantity and nature of genetic variation, we present a new class of models capable of incorporating faster than exponential growth in a coalescent framework. Our work shows that such accelerated growth affects only the population size in the recent past and thus large samples are required to detect the models’ effects on patterns of variation. When we compare models with fixed initial growth rate, models with accelerating growth achieve very large current population sizes and large samples from these populations contain more variation than samples from populations with constant growth. This increase is driven almost entirely by an increase in singleton variation. Moreover, linkage disequilibrium decays faster in populations with accelerating growth. When we instead condition on current population size, models with accelerating growth result in less overall variation and slower linkage disequilibrium decay compared to models with exponential growth. We also find that pairwise linkage disequilibrium of very rare variants contains information about growth rates in the recent past. Finally, we demonstrate that models of accelerating growth may substantially change estimates of present-day effective population sizes and growth times. PMID:24381333
The impact of accelerating faster than exponential population growth on genetic variation.
Reppell, Mark; Boehnke, Michael; Zöllner, Sebastian
2014-03-01
Current human sequencing projects observe an abundance of extremely rare genetic variation, suggesting recent acceleration of population growth. To better understand the impact of such accelerating growth on the quantity and nature of genetic variation, we present a new class of models capable of incorporating faster than exponential growth in a coalescent framework. Our work shows that such accelerated growth affects only the population size in the recent past and thus large samples are required to detect the models' effects on patterns of variation. When we compare models with fixed initial growth rate, models with accelerating growth achieve very large current population sizes and large samples from these populations contain more variation than samples from populations with constant growth. This increase is driven almost entirely by an increase in singleton variation. Moreover, linkage disequilibrium decays faster in populations with accelerating growth. When we instead condition on current population size, models with accelerating growth result in less overall variation and slower linkage disequilibrium decay compared to models with exponential growth. We also find that pairwise linkage disequilibrium of very rare variants contains information about growth rates in the recent past. Finally, we demonstrate that models of accelerating growth may substantially change estimates of present-day effective population sizes and growth times.
Perrier, E; Leduc, P A; Manen, O; Lerecouvreux, M; Deroche, J; Paris, J F; Doireau, Ph; Quiniou, G; Geffroy, S; Carlioz, R
2005-01-01
Aerobatics is an aerial sport which has many physiological constraints, principally cardiovascular, with a risk if not adapted of sudden mid-air incapacity which could jeopardise aviation safety, and thus justifies the selection and surveillance of pilots. The aeronautical constraints during flight are multiple, related to the environment traversed, how the aircraft functions and its movements. Those which cause accelerations (+G in particular) pose the problem of haemodynamic tolerance because they can induce loss of consciousness due to cerebral hypoxia. Tolerance of acceleration varies among individuals; it can be improved with training, certain protective manoeuvres, and is reduced by hypoxia, certain medications, dehydration and heat. Moreover, in aerobatics certain tricks require manoeuvres which reduce this tolerance to +G accelerations. This is the "push-pull" effect (_G acceleration immediately followed by +G acceleration). This leads to a risk of sudden loss of consciousness with a load factor much lower than that which the pilot knows he is capable of tolerating. Besides the haemodynamic effects, the existence of an actual acceleration cardiomyopathy has been suggested but has not been proven in man. Finally, while changes in cardiac rhythm during accelerations are usual and relate to changes in vaso-sympathetic balance, ventricular and supra-ventricular rhythm disturbances are rare and are related to the intensity and duration of the acceleration.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rai, Varun
This project sought to enable electric utilities in Texas to accelerate diffusion of residential solar photovoltaic (PV) by systematically identifying and targeting existing barriers to PV adoption. A core goal of the project was to develop an integrated research framework that combines survey research, econometric modeling, financial modeling, and implementation and evaluation of pilot projects to study the PV diffusion system. This project considered PV diffusion as an emergent system, with attention to the interactions between the constituent parts of the PV socio-technical system including: economics of individual decision-making; peer and social influences; behavioral responses; and information and transaction costs.more » We also conducted two pilot projects, which have yielded new insights into behavioral and informational aspects of PV adoption. Finally, this project has produced robust and generalizable results that will provide deeper insights into the technology-diffusion process that will be applicable for the design of utility programs for other technologies such as home-energy management systems and plug-in electric vehicles. When we started this project in 2013 there was little systematic research on characterizing the decision-making process of households interested in adopting PV. This project was designed to fill that research gap by analyzing the PV adoption process from the consumers' decision-making perspective and with the objective to systematically identifying and addressing the barriers that consumers face in the adoption of PV. The two key components of that decision-making process are consumers' evaluation of: (i) uncertainties and non-monetary costs associated with the technology and (ii) the direct monetary cost-benefit. This project used an integrated approach to study both the non-monetary and the monetary components of the consumer decision-making process.« less
NASA Technical Reports Server (NTRS)
Fredrickson, C. D.
1978-01-01
Various resource data are presented showing that geothermal energy has the potential of satisfying a singificant part of California's increasing energy needs. General factors slowing the development of geothermal energy in California are discussed and required actions to accelerate its progress are presented. Finally, scenarios for developing the most promising prospects in the state directed at timely on-line power are given. Specific actions required to realize each of these individual scenarios are identified.
Evoked Potential Studies of the Effects of Impact Acceleration on the Motor Nervous System,
1983-01-01
experimental animals subjected to -Y ampere) were applied sufficient to obtain good (lateral impact) acceleration and animals sub- afferent evoked...NBDL -Y impact experiments were processed at the EP recorded from these animals before and after Texas Research Institute of Mental Sciences impact were...adjustments were made to playback discriminators and cord in a lateral (-Y) collision. Each and the sampling interval. The final digit. -e d, J animal was
NASA Technical Reports Server (NTRS)
Perez-Peraza, J.; Alvarez, M.; Laville, A.; Gallegos, A.
1985-01-01
Energy spectra of photons emitted from Bremsstrahlung (BR) of energetic electrons with matter, is obtained from the deconvolution of the electron energy spectra. It can be inferred that the scenario for the production of X-rays and gamma rays in solar flares may vary from event to event. However, it is possible in many cases to associated low energy events to impulsive acceleration, and the high energy phase of some events to stochastic acceleration. In both cases, flare particles seem to be strongly modulated by local energy losses. Electric field acceleration, associated to neutral current sheets is a suitable candidate for impulsive acceleration. Finally, that the predominant radiation process of this radiation is the inverse Compton effect due to the local flare photon field.
Weigand, Annika; Beier, Justus P; Hess, Andreas; Gerber, Thomas; Arkudas, Andreas; Horch, Raymund E; Boos, Anja M
2015-05-01
During the last decades, a range of excellent and promising strategies in Bone Tissue Engineering have been developed. However, the remaining major problem is the lack of vascularization. In this study, extrinsic and intrinsic vascularization strategies were combined for acceleration of vascularization. For optimal biomechanical stability of the defect site and simplifying future transition into clinical application, a primary stable and approved nanostructured bone substitute in clinically relevant size was used. An arteriovenous (AV) loop was microsurgically created in sheep and implanted, together with the bone substitute, in either perforated titanium chambers (intrinsic/extrinsic) for different time intervals of up to 18 weeks or isolated Teflon(®) chambers (intrinsic) for 18 weeks. Over time, magnetic resonance imaging and micro-computed tomography (CT) analyses illustrate the dense vascularization arising from the AV loop. The bone substitute was completely interspersed with newly formed tissue after 12 weeks of intrinsic/extrinsic vascularization and after 18 weeks of intrinsic/extrinsic and intrinsic vascularization. Successful matrix change from an inorganic to an organic scaffold could be demonstrated in vascularized areas with scanning electron microscopy and energy dispersive X-ray spectroscopy. Using the intrinsic vascularization method only, the degradation of the scaffold and osteoclastic activity was significantly lower after 18 weeks, compared with 12 and 18 weeks in the combined intrinsic-extrinsic model. Immunohistochemical staining revealed an increase in bone tissue formation over time, without a difference between intrinsic/extrinsic and intrinsic vascularization after 18 weeks. This study presents the combination of extrinsic and intrinsic vascularization strategies for the generation of an axially vascularized bone substitute in clinically relevant size using a large animal model. The additional extrinsic vascularization promotes tissue ingrowth and remodeling processes of the bone substitute. Extrinsic vessels contribute to faster vascularization and finally anastomose with intrinsic vasculature, allowing microvascular transplantation of the bone substitute after a shorter prevascularization time than using the intrinsic method only. It can be reasonably assumed that the usage of perforated chambers can significantly reduce the time until transplantation of bone constructs. Finally, this study paves the way for further preclinical testing for proof of the concept as a basis for early clinical applicability.
Defect Genome of Cubic Perovskites for Fuel Cell Applications
DOE Office of Scientific and Technical Information (OSTI.GOV)
Balachandran, Janakiraman; Lin, Lianshan; Anchell, Jonathan S.
Heterogeneities such as point defects, inherent to material systems, can profoundly influence material functionalities critical for numerous energy applications. This influence in principle can be identified and quantified through development of large defect data sets which we call the defect genome, employing high-throughput ab initio calculations. However, high-throughput screening of material models with point defects dramatically increases the computational complexity and chemical search space, creating major impediments toward developing a defect genome. In this paper, we overcome these impediments by employing computationally tractable ab initio models driven by highly scalable workflows, to study formation and interaction of various point defectsmore » (e.g., O vacancies, H interstitials, and Y substitutional dopant), in over 80 cubic perovskites, for potential proton-conducting ceramic fuel cell (PCFC) applications. The resulting defect data sets identify several promising perovskite compounds that can exhibit high proton conductivity. Furthermore, the data sets also enable us to identify and explain, insightful and novel correlations among defect energies, material identities, and defect-induced local structural distortions. Finally, such defect data sets and resultant correlations are necessary to build statistical machine learning models, which are required to accelerate discovery of new materials.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lundstrom, Blake R.
The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is Australia's national science agency. CSIRO received funding from the Australian Solar Institute (ASI) for the United States-Australia Solar Energy Collaboration (USASEC) project 1-USO032 Plug and Play Solar Power: Simplifying the Integration of Solar Energy in Hybrid Applications (Broader Project). The Australian Solar Institute (ASI) operated from August 2009 to December 2012 before being merged into the Australian Renewable Energy Agency (ARENA). The Broader Project sought to simplify the integration, accelerate the deployment, and lower the cost of solar energy in hybrid distributed generation applications by creating plug and play solar technology.more » CSIRO worked with the National Renewable Energy Laboratory (NREL) as set out in a Joint Work Statement to review communications protocols relevant to plug-and-play technology and perform prototype testing in its Energy System Integration Facility (ESIF). For the avoidance of doubt, this CRADA did not cover the whole of the Broader Project and only related to the work described in the Joint Work Statement, which was carried out by NREL.« less
Defect Genome of Cubic Perovskites for Fuel Cell Applications
Balachandran, Janakiraman; Lin, Lianshan; Anchell, Jonathan S.; ...
2017-10-10
Heterogeneities such as point defects, inherent to material systems, can profoundly influence material functionalities critical for numerous energy applications. This influence in principle can be identified and quantified through development of large defect data sets which we call the defect genome, employing high-throughput ab initio calculations. However, high-throughput screening of material models with point defects dramatically increases the computational complexity and chemical search space, creating major impediments toward developing a defect genome. In this paper, we overcome these impediments by employing computationally tractable ab initio models driven by highly scalable workflows, to study formation and interaction of various point defectsmore » (e.g., O vacancies, H interstitials, and Y substitutional dopant), in over 80 cubic perovskites, for potential proton-conducting ceramic fuel cell (PCFC) applications. The resulting defect data sets identify several promising perovskite compounds that can exhibit high proton conductivity. Furthermore, the data sets also enable us to identify and explain, insightful and novel correlations among defect energies, material identities, and defect-induced local structural distortions. Finally, such defect data sets and resultant correlations are necessary to build statistical machine learning models, which are required to accelerate discovery of new materials.« less
High Performance Computing Modeling Advances Accelerator Science for High-Energy Physics
Amundson, James; Macridin, Alexandru; Spentzouris, Panagiotis
2014-07-28
The development and optimization of particle accelerators are essential for advancing our understanding of the properties of matter, energy, space, and time. Particle accelerators are complex devices whose behavior involves many physical effects on multiple scales. Therefore, advanced computational tools utilizing high-performance computing are essential for accurately modeling them. In the past decade, the US Department of Energy's SciDAC program has produced accelerator-modeling tools that have been employed to tackle some of the most difficult accelerator science problems. The authors discuss the Synergia framework and its applications to high-intensity particle accelerator physics. Synergia is an accelerator simulation package capable ofmore » handling the entire spectrum of beam dynamics simulations. Our authors present Synergia's design principles and its performance on HPC platforms.« less
MICROWAVE-ACCELERATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS
The application of microwave-accelerated solventless synthetic protocols in multicomponent (MCC) reactions will be exemplified by several condensation and cyclization reactions including the rapid one-pot assembly of valuable heterocyclic compounds from in situ generated intermed...
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rodriguez-Fernandez, Luis
2010-09-10
Although the developments of particle accelerators are devoted to basic study of matter constituents, since the beginning these machines have been applied with different purposes in many areas also. Today particle accelerators are essential instruments for science and technology. This work presents an overview of the main application for direct particle irradiation with accelerator in material science, biology and medicine. They are used for material synthesis by ion implantation and charged particle irradiation; to make coatings and micromachining; to characterize broad kind of samples by ion beam analysis techniques; as mass spectrometers for atomic isotopes determination. In biomedicine the acceleratorsmore » are applied for the study of effects by charged particles on cells. In medicine the radiotherapy by electron irradiation is widely used, while hadrontherapy is still under development. Also, they are necessary for short life radioisotopes production required in radiodiagnostic.« less
SABRE, a 10-MV linear induction accelerator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Corely, J.P.; Alexander, J.A.; Pankuch, P.J.
SABRE (Sandia Accelerator and Beam Research Experiment) is a 10-MV, 250-kA, 40-ns linear induction accelerator. It was designed to be used in positive polarity output. Positive polarity accelerators are important for application to Sandia's ICF (Inertial Confinement Fusion) and LMF (Laboratory Microfusion Facility) program efforts. SABRE was built to allow a more detailed study of pulsed power issues associated with positive polarity output machines. MITL (Magnetically Insulated Transmission Line) voltage adder efficiency, extraction ion diode development, and ion beam transport and focusing. The SABRE design allows the system to operate in either positive polarity output for ion extraction applications ormore » negative polarity output for more conventional electron beam loads. Details of the design of SABRE and the results of initial machine performance in negative polarity operation are presented in this paper. 13 refs., 12 figs., 1 tab.« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Spentzouris, Panagiotis; /Fermilab; Cary, John
The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessarymore » accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors.« less
A silicon carbide array for electrocorticography and peripheral nerve recording.
Diaz-Botia, C A; Luna, L E; Neely, R M; Chamanzar, M; Carraro, C; Carmena, J M; Sabes, P N; Maboudian, R; Maharbiz, M M
2017-10-01
Current neural probes have a limited device lifetime of a few years. Their common failure mode is the degradation of insulating films and/or the delamination of the conductor-insulator interfaces. We sought to develop a technology that does not suffer from such limitations and would be suitable for chronic applications with very long device lifetimes. We developed a fabrication method that integrates polycrystalline conductive silicon carbide with insulating silicon carbide. The technology employs amorphous silicon carbide as the insulator and conductive silicon carbide at the recording sites, resulting in a seamless transition between doped and amorphous regions of the same material, eliminating heterogeneous interfaces prone to delamination. Silicon carbide has outstanding chemical stability, is biocompatible, is an excellent molecular barrier and is compatible with standard microfabrication processes. We have fabricated silicon carbide electrode arrays using our novel fabrication method. We conducted in vivo experiments in which electrocorticography recordings from the primary visual cortex of a rat were obtained and were of similar quality to those of polymer based electrocorticography arrays. The silicon carbide electrode arrays were also used as a cuff electrode wrapped around the sciatic nerve of a rat to record the nerve response to electrical stimulation. Finally, we demonstrated the outstanding long term stability of our insulating silicon carbide films through accelerated aging tests. Clinical translation in neural engineering has been slowed in part due to the poor long term performance of current probes. Silicon carbide devices are a promising technology that may accelerate this transition by enabling truly chronic applications.
NASA Astrophysics Data System (ADS)
Bocciolone, Marco; Bucca, Giuseppe; Collina, Andrea; Comolli, Lorenzo
2013-12-01
One of the most common way to collect the traction current needed for the underground vehicle operation is by using the pantograph-overhead line system. The periodically check of pantographs and overhead lines is important to assure the correct interaction between the two systems in terms of good current collection quality. The main diagnostic tools are the monitoring of the vertical force between the overhead line and the pantograph head, and the vertical acceleration on the pantograph head. The pantograph system works under high voltage (1500 V, DC, in our tests) and high electromagnetic disturbances are present. For this reason, traditional electrical sensors can be used only with particular precautions that complicate the measurement set up; fibre optic sensors, and in particular fibre Bragg grating (FBG) sensors, are particularly suitable for this application. In this paper, the application of the FBG sensors on a pantograph for the monitoring of underground pantograph-catenary system is presented. FBG sensors are used to measure both the contact force and the vertical acceleration of the pantograph head. The same measurements are also gathered with a traditional electrical system, allowing a comparison. The result is a very good agreement between electrical and optical measurements, except in particular frequency ranges where the different positioning of the sensors influences the output, limiting the comparison. Moreover, some interesting results on the dynamic behaviour of the pantograph and its interaction with the overhead line are presented. Finally, a method to point out the main defects on the overhead line is shown.
A silicon carbide array for electrocorticography and peripheral nerve recording
NASA Astrophysics Data System (ADS)
Diaz-Botia, C. A.; Luna, L. E.; Neely, R. M.; Chamanzar, M.; Carraro, C.; Carmena, J. M.; Sabes, P. N.; Maboudian, R.; Maharbiz, M. M.
2017-10-01
Objective. Current neural probes have a limited device lifetime of a few years. Their common failure mode is the degradation of insulating films and/or the delamination of the conductor-insulator interfaces. We sought to develop a technology that does not suffer from such limitations and would be suitable for chronic applications with very long device lifetimes. Approach. We developed a fabrication method that integrates polycrystalline conductive silicon carbide with insulating silicon carbide. The technology employs amorphous silicon carbide as the insulator and conductive silicon carbide at the recording sites, resulting in a seamless transition between doped and amorphous regions of the same material, eliminating heterogeneous interfaces prone to delamination. Silicon carbide has outstanding chemical stability, is biocompatible, is an excellent molecular barrier and is compatible with standard microfabrication processes. Main results. We have fabricated silicon carbide electrode arrays using our novel fabrication method. We conducted in vivo experiments in which electrocorticography recordings from the primary visual cortex of a rat were obtained and were of similar quality to those of polymer based electrocorticography arrays. The silicon carbide electrode arrays were also used as a cuff electrode wrapped around the sciatic nerve of a rat to record the nerve response to electrical stimulation. Finally, we demonstrated the outstanding long term stability of our insulating silicon carbide films through accelerated aging tests. Significance. Clinical translation in neural engineering has been slowed in part due to the poor long term performance of current probes. Silicon carbide devices are a promising technology that may accelerate this transition by enabling truly chronic applications.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fukushima, Toshio, E-mail: Toshio.Fukushima@nao.ac.jp
In order to obtain the gravitational field of a general finite body inside its Brillouin sphere, we developed a new method to compute the field accurately. First, the body is assumed to consist of some layers in a certain spherical polar coordinate system and the volume mass density of each layer is expanded as a Maclaurin series of the radial coordinate. Second, the line integral with respect to the radial coordinate is analytically evaluated in a closed form. Third, the resulting surface integrals are numerically integrated by the split quadrature method using the double exponential rule. Finally, the associated gravitationalmore » acceleration vector is obtained by numerically differentiating the numerically integrated potential. Numerical experiments confirmed that the new method is capable of computing the gravitational field independently of the location of the evaluation point, namely whether inside, on the surface of, or outside the body. It can also provide sufficiently precise field values, say of 14–15 digits for the potential and of 9–10 digits for the acceleration. Furthermore, its computational efficiency is better than that of the polyhedron approximation. This is because the computational error of the new method decreases much faster than that of the polyhedron models when the number of required transcendental function calls increases. As an application, we obtained the gravitational field of 433 Eros from its shape model expressed as the 24 × 24 spherical harmonic expansion by assuming homogeneity of the object.« less
Illinois Accelerator Research Center
NASA Astrophysics Data System (ADS)
Kroc, Thomas K.; Cooper, Charlie A.
The Illinois Accelerator Research Center (IARC) hosts a new accelerator development program at Fermi National Accelerator Laboratory. IARC provides access to Fermi's state-of-the-art facilities and technologies for research, development and industrialization of particle accelerator technology. In addition to facilitating access to available existing Fermi infrastructure, the IARC Campus has a dedicated 36,000 ft2 Heavy Assembly Building (HAB) with all the infrastructure needed to develop, commission and operate new accelerators. Connected to the HAB is a 47,000 ft2 Office, Technology and Engineering (OTE) building, paid for by the state, that has office, meeting, and light technical space. The OTE building, which contains the Accelerator Physics Center, and nearby Accelerator and Technical divisions provide IARC collaborators with unique access to world class expertise in a wide array of accelerator technologies. At IARC scientists and engineers from Fermilab and academia work side by side with industrial partners to develop breakthroughs in accelerator science and translate them into applications for the nation's health, wealth and security.
Progress with High-Field Superconducting Magnets for High-Energy Colliders
NASA Astrophysics Data System (ADS)
Apollinari, Giorgio; Prestemon, Soren; Zlobin, Alexander V.
2015-10-01
One of the possible next steps for high-energy physics research relies on a high-energy hadron or muon collider. The energy of a circular collider is limited by the strength of bending dipoles, and its maximum luminosity is determined by the strength of final focus quadrupoles. For this reason, the high-energy physics and accelerator communities have shown much interest in higher-field and higher-gradient superconducting accelerator magnets. The maximum field of NbTi magnets used in all present high-energy machines, including the LHC, is limited to ˜10 T at 1.9 K. Fields above 10 T became possible with the use of Nb3Sn superconductors. Nb3Sn accelerator magnets can provide operating fields up to ˜15 T and can significantly increase the coil temperature margin. Accelerator magnets with operating fields above 15 T require high-temperature superconductors. This review discusses the status and main results of Nb3Sn accelerator magnet research and development and work toward 20-T magnets.
Using Phase Space Density Profiles to Investigate the Radiation Belt Seed Population
NASA Astrophysics Data System (ADS)
Boyd, A. J.; Spence, H.; Reeves, G. D.; Blake, J. B.; Fennell, J. F.; Claudepierre, S. G.; Turner, D. L.
2013-12-01
It is believed that particles with energies of 100s of keV play a critical role in the acceleration of electrons within the radiation belt. Through wave particle interactions, these so called 'seed electrons' can be accelerated up to energies greater than 1 MeV. Using data from the MagEIS (Magnetic Electron Ion Spectrometer) Instrument onboard the Van Allen Probes we calculate phase space density within the radiation belts over a wide range of mu and K values. These phase space density profiles are combined with those from THEMIS, in order to see how the phase space density evolves over a large range of L*. In this presentation we examine how the seed electron population evolves in both time and L* during acceleration events. Comparing this to the evolution of the higher mu electron population allows us to determine what role the seed electrons played in the acceleration process. Finally, we compare several of these storms to examine the importance of the seed population to the acceleration process.
Progress with high-field superconducting magnets for high-energy colliders
Apollinari, Giorgio; Prestemon, Soren; Zlobin, Alexander V.
2015-10-01
One of the possible next steps for high-energy physics research relies on a high-energy hadron or muon collider. The energy of a circular collider is limited by the strength of bending dipoles, and its maximum luminosity is determined by the strength of final focus quadrupoles. For this reason, the high-energy physics and accelerator communities have shown much interest in higher-field and higher-gradient superconducting accelerator magnets. The maximum field of NbTi magnets used in all present high-energy machines, including the LHC, is limited to ~10 T at 1.9 K. Fields above 10 T became possible with the use of Nbmore » $$_3$$Sn superconductors. Nb$$_3$$Sn accelerator magnets can provide operating fields up to ~15 T and can significantly increase the coil temperature margin. Accelerator magnets with operating fields above 15 T require high-temperature superconductors. Furthermore, this review discusses the status and main results of Nb$$_3$$Sn accelerator magnet research and development and work toward 20-T magnets.« less
Parallel/Vector Integration Methods for Dynamical Astronomy
NASA Astrophysics Data System (ADS)
Fukushima, Toshio
1999-01-01
This paper reviews three recent works on the numerical methods to integrate ordinary differential equations (ODE), which are specially designed for parallel, vector, and/or multi-processor-unit(PU) computers. The first is the Picard-Chebyshev method (Fukushima, 1997a). It obtains a global solution of ODE in the form of Chebyshev polynomial of large (> 1000) degree by applying the Picard iteration repeatedly. The iteration converges for smooth problems and/or perturbed dynamics. The method runs around 100-1000 times faster in the vector mode than in the scalar mode of a certain computer with vector processors (Fukushima, 1997b). The second is a parallelization of a symplectic integrator (Saha et al., 1997). It regards the implicit midpoint rules covering thousands of timesteps as large-scale nonlinear equations and solves them by the fixed-point iteration. The method is applicable to Hamiltonian systems and is expected to lead an acceleration factor of around 50 in parallel computers with more than 1000 PUs. The last is a parallelization of the extrapolation method (Ito and Fukushima, 1997). It performs trial integrations in parallel. Also the trial integrations are further accelerated by balancing computational load among PUs by the technique of folding. The method is all-purpose and achieves an acceleration factor of around 3.5 by using several PUs. Finally, we give a perspective on the parallelization of some implicit integrators which require multiple corrections in solving implicit formulas like the implicit Hermitian integrators (Makino and Aarseth, 1992), (Hut et al., 1995) or the implicit symmetric multistep methods (Fukushima, 1998), (Fukushima, 1999).
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mackintosh, Angela
For over five decades the Sellafield Site has been central to the UK's nuclear programme. Now operated by Sellafield Ltd, under the management of Parent Body Organisation Nuclear Management Partners (NMP), a consortium of URS Washington Division, AMEC and AREVA is focussed on the decommissioning of historical facilities. When Decommissioning commenced in the late 1980's the site focus at that time was on commercial reprocessing and waste management. Now through the implementation of a company change programme, emphasis has shifted towards accelerated risk and hazard reduction of degraded legacy plants with nuclear inventory whilst ensuring value for money for themore » customer, the Nuclear Decommissioning Authority. This paper will describe the management success by the Site owners in delivering a successful change programme. The paper will explain how the site has transitioned to the INPO Standard Nuclear Performance Model (SNPM) and how through the use of a change maturity matrix has contributed to the accelerated reduction in high risk high hazard nuclear facilities. The paper will explain in detail how the Decommissioning Programme Office has facilitated and coordinated the Governance and assured delivery of the change plan and how successful application of visual management has aided the communication of its progress. Finally, the paper will discuss how the Delivery Schedules have proved critical for presenting the change plan to Key Stakeholders, Government Owners and Powerful Regulators. Overall, this paper provides an insight into how a massive change programme is being managed within one of the world's highest regulated industries. (authors)« less
DOE Office of Scientific and Technical Information (OSTI.GOV)
Das, Susanta Kumar, E-mail: skdasfpy@kiit.ac.in; Andreev, Alexander; Braenzel, Julia
2016-03-21
The feasibility of femtosecond laser-induced periodic nanostructures on thin Ti and Cu foils (thickness down to 1 μm) is demonstrated. At pulse durations of 120 fs and a wavelength of 400 nm, periods of 61 nm to 320 nm were obtained. Particle-in-cell simulations of laser ion acceleration processes with such nanostructured targets indicate their potential for high energy particle physics applications. In particular, a measurable enhancement of the proton cut-off energy and a significant enhancement of the number of accelerated particles compared to non- or weakly structured targets of same thickness and material are expected.
A Thermal Runaway Failure Model for Low-Voltage BME Ceramic Capacitors with Defects
NASA Technical Reports Server (NTRS)
Teverovsky, Alexander
2017-01-01
Reliability of base metal electrode (BME) multilayer ceramic capacitors (MLCCs) that until recently were used mostly in commercial applications, have been improved substantially by using new materials and processes. Currently, the inception of intrinsic wear-out failures in high quality capacitors became much greater than the mission duration in most high-reliability applications. However, in capacitors with defects degradation processes might accelerate substantially and cause infant mortality failures. In this work, a physical model that relates the presence of defects to reduction of breakdown voltages and decreasing times to failure has been suggested. The effect of the defect size has been analyzed using a thermal runaway model of failures. Adequacy of highly accelerated life testing (HALT) to predict reliability at normal operating conditions and limitations of voltage acceleration are considered. The applicability of the model to BME capacitors with cracks is discussed and validated experimentally.
Research opportunities with compact accelerator-driven neutron sources
NASA Astrophysics Data System (ADS)
Anderson, I. S.; Andreani, C.; Carpenter, J. M.; Festa, G.; Gorini, G.; Loong, C.-K.; Senesi, R.
2016-10-01
Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target-moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.
Testing Done for Lorentz Force Accelerators and Electrodeless Propulsion Technology Development
NASA Technical Reports Server (NTRS)
Pencil, Eric J.; Gilland, James H.; Arrington, Lynn A.; Kamhawi, Hani
2004-01-01
The NASA Glenn Research Center is developing Lorentz force accelerators and electrodeless plasma propulsion for a wide variety of space applications. These applications range from precision control of formation-flying spacecraft to primary propulsion for very high power interplanetary spacecraft. The specific thruster technologies being addressed are pulsed plasma thrusters, magnetoplasmadynamic thrusters, and helicon-electron cyclotron resonance acceleration thrusters. The pulsed plasma thruster mounted on the Earth Observing-1 spacecraft was operated successfully in orbit in 2002. The two-axis thruster system is fully incorporated in the attitude determination and control system and is being used to automatically counteract disturbances in the pitch axis of the spacecraft. Recent on-orbit operations have focused on extended operations to add flight operation time to the total accumulated thruster life. The results of the experiments pave the way for electric propulsion applications on future Earth-imaging satellites.
Baczewski, Andrew D; Miller, Nicholas C; Shanker, Balasubramaniam
2012-04-01
The analysis of fields in periodic dielectric structures arise in numerous applications of recent interest, ranging from photonic bandgap structures and plasmonically active nanostructures to metamaterials. To achieve an accurate representation of the fields in these structures using numerical methods, dense spatial discretization is required. This, in turn, affects the cost of analysis, particularly for integral-equation-based methods, for which traditional iterative methods require O(N2) operations, N being the number of spatial degrees of freedom. In this paper, we introduce a method for the rapid solution of volumetric electric field integral equations used in the analysis of doubly periodic dielectric structures. The crux of our method is the accelerated Cartesian expansion algorithm, which is used to evaluate the requisite potentials in O(N) cost. Results are provided that corroborate our claims of acceleration without compromising accuracy, as well as the application of our method to a number of compelling photonics applications.
Self-accelerating self-trapped nonlinear beams of Maxwell's equations.
Kaminer, Ido; Nemirovsky, Jonathan; Segev, Mordechai
2012-08-13
We present shape-preserving self-accelerating beams of Maxwell's equations with optical nonlinearities. Such beams are exact solutions to Maxwell's equations with Kerr or saturable nonlinearity. The nonlinearity contributes to self-trapping and causes backscattering. Those effects, together with diffraction effects, work to maintain shape-preserving acceleration of the beam on a circular trajectory. The backscattered beam is found to be a key issue in the dynamics of such highly non-paraxial nonlinear beams. To study that, we develop two new techniques: projection operator separating the forward and backward waves, and reverse simulation. Finally, we discuss the possibility that such beams would reflect themselves through the nonlinear effect, to complete a 'U' shaped trajectory.
Synergia: an accelerator modeling tool with 3-D space charge
DOE Office of Scientific and Technical Information (OSTI.GOV)
Amundson, James F.; Spentzouris, P.; /Fermilab
2004-07-01
High precision modeling of space-charge effects, together with accurate treatment of single-particle dynamics, is essential for designing future accelerators as well as optimizing the performance of existing machines. We describe Synergia, a high-fidelity parallel beam dynamics simulation package with fully three dimensional space-charge capabilities and a higher order optics implementation. We describe the computational techniques, the advanced human interface, and the parallel performance obtained using large numbers of macroparticles. We also perform code benchmarks comparing to semi-analytic results and other codes. Finally, we present initial results on particle tune spread, beam halo creation, and emittance growth in the Fermilab boostermore » accelerator.« less
Acceleration effects observed in optical data taken in Spacelab 3 FES
NASA Technical Reports Server (NTRS)
Trolinger, James; Lal, Ravindra; Ruff, Rudy
1990-01-01
Optical instrumentation in the Fluids Experiment System (FES) is briefly described. Samples of the data produced by the schlieren and holography systems during the Spacelab 3 flight are then presented with some of the holographic interferometry data being presented for the first time. Acceleration effects that can be observed in these data are discussed and the potential for using them as a basis for measurement is explored. This includes the tracking of deliberately introduced tracer particles and density gradients in the FES, the analysis of the existing concentration gradients, and a new fiber optic G-meter concept. Finally, some of the plans for acceleration measurement in the upcoming International Microgravity-1/FES are described.
Status of the University of Rochester tandem upgrade
NASA Astrophysics Data System (ADS)
Cross, Clinton; Miller, Thomas
1986-05-01
The status of the University of Rochester tandem Van de Graaff accelerator upgrade is reviewed. The accelerator upgrade to 18 MV consists of extended tubes, shielded resistors, dead-section ion pumping, two rotating insulating power shaft systems to provide power to the dead sections and terminal, and a pelletron charging system to replace the charging belt. Control of many of the accelerator operating systems will be done by two IBM personal computers. The negative ion injector diffusion pump, isolation transformer, preacceleration high-voltage power supply, and high-voltage corona enclosure will all be replaced. Finally, the SF6 gas handling system will be improved with the addition of a second set of gas dryers and a larger recirculating pump.
Characterization of Tantalum Polymer Capacitors
NASA Technical Reports Server (NTRS)
Spence, Penelope
2012-01-01
Overview Reviewed data Caution must be taken when accelerating test conditions Data not useful to establish an acceleration model Introduction of new failure mechanism skewing results Evidence of Anti-Wear-Out De-doping of polymer Decreased capacitance Increased ESR Not dielectric breakdown Needs further investigation Further investigation into tantalum polymer capacitor technology Promising acceleration model for Manufacturer A Possibility for use in high-reliability space applications with suitable voltage derating.
Resonant ion acceleration by plasma jets: Effects of jet breaking and the magnetic-field curvature.
Artemyev, A V; Vasiliev, A A
2015-05-01
In this paper we consider resonant ion acceleration by a plasma jet originating from the magnetic reconnection region. Such jets propagate in the background magnetic field with significantly curved magnetic-field lines. Decoupling of ion and electron motions at the leading edge of the jet results in generation of strong electrostatic fields. Ions can be trapped by this field and get accelerated along the jet front. This mechanism of resonant acceleration resembles surfing acceleration of charged particles at a shock wave. To describe resonant acceleration of ions, we use adiabatic theory of resonant phenomena. We show that particle motion along the curved field lines significantly influences the acceleration rate. The maximum gain of energy is determined by the particle's escape from the system due to this motion. Applications of the proposed mechanism to charged-particle acceleration in the planetary magnetospheres and the solar corona are discussed.
Multi-beam linear accelerator EVT
NASA Astrophysics Data System (ADS)
Teryaev, Vladimir E.; Kazakov, Sergey Yu.; Hirshfield, Jay L.
2016-09-01
A novel electron multi-beam accelerator is presented. The accelerator, short-named EVT (Electron Voltage Transformer) belongs to the class of two-beam accelerators. It combines an RF generator and essentially an accelerator within the same vacuum envelope. Drive beam-lets and an accelerated beam are modulated in RF modulators and then bunches pass into an accelerating structure, comprising uncoupled with each other and inductive tuned cavities, where the energy transfer from the drive beams to the accelerated beam occurs. A phasing of bunches is solved by choice correspond distances between gaps of the adjacent cavities. Preliminary results of numerical simulations and the initial specification of EVT operating in S-band, with a 60 kV gun and generating a 2.7 A, 1.1 MV beam at its output is presented. A relatively high efficiency of 67% and high design average power suggest that EVT can find its use in industrial applications.
Multi-beam linear accelerator EVT
Teryaev, Vladimir E.; Kazakov, Sergey Yu.; Hirshfield, Jay L.
2016-03-29
A novel electron multi-beam accelerator is presented. The accelerator, short-named EVT (Electron Voltage Transformer) belongs to the class of two-beam accelerators. It combines an RF generator and essentially an accelerator within the same vacuum envelope. Drive beam-lets and an accelerated beam are modulated in RF modulators and then bunches pass into an accelerating structure, comprising uncoupled with each other and inductive tuned cavities, where the energy transfer from the drive beams to the accelerated beam occurs. A phasing of bunches is solved by choice correspond distances between gaps of the adjacent cavities. Preliminary results of numerical simulations and the initialmore » specification of EVT operating in S-band, with a 60 kV gun and generating a 2.7 A, 1.1 MV beam at its output is presented. Furthermore, a relatively high efficiency of 67% and high design average power suggest that EVT can find its use in industrial applications.« less
Kole, J S; Beekman, F J
2006-02-21
Statistical reconstruction methods offer possibilities to improve image quality as compared with analytical methods, but current reconstruction times prohibit routine application in clinical and micro-CT. In particular, for cone-beam x-ray CT, the use of graphics hardware has been proposed to accelerate the forward and back-projection operations, in order to reduce reconstruction times. In the past, wide application of this texture hardware mapping approach was hampered owing to limited intrinsic accuracy. Recently, however, floating point precision has become available in the latest generation commodity graphics cards. In this paper, we utilize this feature to construct a graphics hardware accelerated version of the ordered subset convex reconstruction algorithm. The aims of this paper are (i) to study the impact of using graphics hardware acceleration for statistical reconstruction on the reconstructed image accuracy and (ii) to measure the speed increase one can obtain by using graphics hardware acceleration. We compare the unaccelerated algorithm with the graphics hardware accelerated version, and for the latter we consider two different interpolation techniques. A simulation study of a micro-CT scanner with a mathematical phantom shows that at almost preserved reconstructed image accuracy, speed-ups of a factor 40 to 222 can be achieved, compared with the unaccelerated algorithm, and depending on the phantom and detector sizes. Reconstruction from physical phantom data reconfirms the usability of the accelerated algorithm for practical cases.
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-01
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POLLUTION DETECTION DOGS: PROOF OF CONCEPT
Dogs have been used extensively in law enforcement and military applications to detect narcotics and explosives for over thirty years. Dogs are regularly used in arson investigations to detect accelerants since they are much more accurate at discriminating between accelerants an...
A new type of accelerator for charged particle cancer therapy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Edgecock, Rob
2013-04-19
Non-scaling Fixed Field Alternating Gradient accelerators (ns-FFAGs) show great potential for the acceleration of protons and light ions for the treatment of certain cancers. They have unique features as they combine techniques from the existing types of accelerators, cyclotrons and synchrotrons, and hence look to have advantages over both for this application. However, these unique features meant that it was necessary to build one of these accelerators to show that it works and to undertake a detailed conceptual design of a medical machine. Both of these have now been done. This paper will describe the concepts of this type ofmore » accelerator, show results from the proof-of-principle machine (EMMA) and described the medical machine (PAMELA).« less
Capacitor Technologies, Applications and Reliability
NASA Technical Reports Server (NTRS)
1981-01-01
Various aspects of capacitor technologies and applications are discussed. Major emphasis is placed on: the causes of failures; accelerated testing; screening tests; destructive physical analysis; applications techniques; and improvements in capacitor capabilities.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Alekhin, S.I.; Ezhela, V.V.; Filimonov, B.B.
We present an indexed guide to the literature experimental particle physics for the years 1988--1992. About 4,000 papers are indexed by Beam/Target/Momentum, Reaction Momentum (including the final state), Final State Particle, and Accelerator/Detector/Experiment. All indices are cross-referenced to the paper`s title and reference in the ID/Reference/Title Index. The information in this guide is also publicly available from a regularly updated computer database.
Theoretical and Experimental Studies in Accelerator Physics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rosenzweig, James
This report describes research supported by the US Dept. of Energy Office of High Energy Physics (OHEP), performed by the UCLA Particle Beam Physics Laboratory (PBPL). The UCLA PBPL has, over the last two decades-plus, played a critical role in the development of advanced accelerators, fundamental beam physics, and new applications enabled by these thrusts, such as new types of accelerator-based light sources. As the PBPL mission is broad it is natural that it has been grown within the context of the accelerator science and technology stewardship of the OHEP. Indeed, steady OHEP support for the program has always beenmore » central to the success of the PBPL; it has provided stability, and above all has set the over-arching themes for our research directions, which have producing over 500 publications (>120 in high level journals). While other agency support has grown notably in recent years, permitting more vigorous pursuit of the program, it is transient by comparison. Beyond permitting program growth in a time of flat OHEP budgets, the influence of other agency missions is found in push to adapt advanced accelerator methods to applications, in light of the success the field has had in proof-of-principle experiments supported first by the DoE OHEP. This three-pronged PBPL program — advanced accelerators, fundamental beam physics and technology, and revolutionary applications — has produced a generation of students that have had a profound affect on the US accelerator physics community. PBPL graduates, numbering 28 in total, form a significant population group in the accelerator community, playing key roles as university faculty, scientific leaders in national labs (two have been named Panofsky Fellows at SLAC), and vigorous proponents of industrial application of accelerators. Indeed, the development of advanced RF, optical and magnet technology at the PBPL has led directly to the spin-off company, RadiaBeam Technologies, now a leading industrial accelerator firm. We note also that PBPL graduates remain as close elaborators for the program after leaving UCLA. The UCLA PBPL program is a foremost developer of on-campus facilities, such as the Neptune and Pegasus Laboratories, providing a uniquely strong environment for student-based research. In addition, the PBPL is a strong user of off-campus national lab facilities, such as SLAC FACET and NLCTA, and the BNL ATF. UCLA has also vigorously participated in the development of these facilities. The dual emphases on off- and on-campus opportunities permit the PBPL to address in an agile way a wide selection of cutting-edge research topics. The topics embraced by this proposal illustrate this program aspect well. These include: GV/m dielectric wakefield acceleration/coherent Cerenkov radiation experiments at FACET (E-201) and the ATF; synergistic laser-excited dielectric accelerator and light source development; plasma wakefield (PWFA) experiments on “Trojan horse” ionization injection (FACET E-210), quasi-nonlinear PWFA at BNL and the production at Neptune high transformer ratio plasma wakes; the inauguration of a new type of RF photoinjector termed “hybrid” at UCLA, and application to PWFA; space-charge dominated beam and cathode/near cathode physics; the study of advanced IFEL systems, for very high energy gain and utilization of novel OAM modes; the physcis of inverse Compton scattering (ICS), with applications to e+ production and γγ colliders; electron diffraction; and advanced beam diagnostics using coherent imaging techniques. These subjects are addressed under the leadership of PBPL director Prof. James Rosenzweig in Task A, and Prof. Pietro Musumeci in Task J, which was initiated following his OHEP Outstanding Junior Investigator award.« less