Science.gov

Sample records for acceptance criteria defined

  1. Defining waste acceptance criteria for the Hanford Replacement Cross-Site Transfer System

    SciTech Connect

    Hudson, J.D.

    1996-04-01

    This document provides a methodology for defining waste acceptance criteria for the Hanford Replacement Cross-Site Transfer System (RCSTS). This methodology includes characterization, transport analysis, and control. A framework is described for each of these functions. A tool was developed for performing the calculations associated with the transport analysis. This tool, a worksheet that is available in formats acceptable for a variety of PC spreadsheet programs, enables a comparison of the pressure required to transport a given slurry at a rate that particulate suspension is maintained to the pressure drop available from the RCSTS.

  2. Hanford Site Solid Waste Acceptance Criteria

    SciTech Connect

    Not Available

    1993-11-17

    This manual defines the Hanford Site radioactive, hazardous, and sanitary solid waste acceptance criteria. Criteria in the manual represent a guide for meeting state and federal regulations; DOE Orders; Hanford Site requirements; and other rules, regulations, guidelines, and standards as they apply to acceptance of radioactive and hazardous solid waste at the Hanford Site. It is not the intent of this manual to be all inclusive of the regulations; rather, it is intended that the manual provide the waste generator with only the requirements that waste must meet in order to be accepted at Hanford Site TSD facilities.

  3. Automated Transportation Management System (ATMS) V2.0 logistics module PBI acceptance criteria

    SciTech Connect

    Weidert, R.S.

    1995-02-28

    This document defines the acceptance criteria for the Automated Transportation Management System V2.0 Logistics Module Performance Based Incentive (PBI). This acceptance criteria will be the primary basis for the generation of acceptance test procedures. The purpose of this document is to define the minimum criteria that must be fulfilled to guarantee acceptance of the Logistics Module.

  4. Nevada Test Site Waste Acceptance Criteria (NTSWAC)

    SciTech Connect

    NNSA /NSO Waste Management Project

    2008-06-01

    This document establishes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, Nevada Test Site Waste Acceptance Criteria (NTSWAC). The NTSWAC provides the requirements, terms, and conditions under which the Nevada Test Site will accept low-level radioactive (LLW) and LLW Mixed Waste (MW) for disposal.

  5. NEVADA TEST SITE WASTE ACCEPTANCE CRITERIA

    SciTech Connect

    U.S. DEPARTMENT OF ENERGY, NATIONAL NUCLEAR SECURITY ADMINISTRATION, NEVADA SITE OFFICE

    2005-07-01

    This document establishes the U. S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site will accept low-level radioactive and mixed waste for disposal. Mixed waste generated within the State of Nevada by NNSA/NSO activities is accepted for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the Nevada Test Site Area 3 and Area 5 Radioactive Waste Management Site for storage or disposal.

  6. Hanford Site solid waste acceptance criteria

    SciTech Connect

    Ellefson, M.D.

    1998-07-01

    Order 5820.2A requires that each treatment, storage, and/or disposal facility (referred to in this document as TSD unit) that manages low-level or transuranic waste (including mixed waste and TSCA PCB waste) maintain waste acceptance criteria. These criteria must address the various requirements to operate the TSD unit in compliance with applicable safety and environmental requirements. This document sets forth the baseline criteria for acceptance of radioactive waste at TSD units operated by WMH. The criteria for each TSD unit have been established to ensure that waste accepted can be managed in a manner that is within the operating requirements of the unit, including environmental regulations, DOE Orders, permits, technical safety requirements, waste analysis plans, performance assessments, and other applicable requirements. Acceptance criteria apply to the following TSD units: the Low-Level Burial Grounds (LLBG) including both the nonregulated portions of the LLBG and trenches 31 and 34 of the 218-W-5 Burial Ground for mixed waste disposal; Central Waste Complex (CWC); Waste Receiving and Processing Facility (WRAP); and T Plant Complex. Waste from all generators, both from the Hanford Site and from offsite facilities, must comply with these criteria. Exceptions can be granted as provided in Section 1.6. Specific waste streams could have additional requirements based on the 1901 identified TSD pathway. These requirements are communicated in the Waste Specification Records (WSRds). The Hanford Site manages nonradioactive waste through direct shipments to offsite contractors. The waste acceptance requirements of the offsite TSD facility must be met for these nonradioactive wastes. This document does not address the acceptance requirements of these offsite facilities.

  7. Nevada Test Site Waste Acceptance Criteria

    SciTech Connect

    U. S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2005-10-01

    This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive (LLW) and mixed waste (MW) for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex (RWMC) for storage or disposal.

  8. Nevada National Security Site Waste Acceptance Criteria

    SciTech Connect

    NSTec Environmental Management

    2010-09-03

    This document establishes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Nevada National Security Site Waste Acceptance Criteria (NNSSWAC). The NNSSWAC provides the requirements, terms, and conditions under which the Nevada National Security Site (NNSS) will accept low-level radioactive waste and mixed low-level waste for disposal. The NNSSWAC includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NNSS Area 3 and Area 5 Radioactive Waste Management Complex for disposal. The NNSA/NSO and support contractors are available to assist you in understanding or interpreting this document. For assistance, please call the NNSA/NSO Waste Management Project at (702) 295-7063 or fax to (702) 295-1153.

  9. Nevada National Security Site Waste Acceptance Criteria

    SciTech Connect

    NSTec Environmental Management

    2011-01-01

    This document establishes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) Nevada National Security Site Waste Acceptance Criteria (NNSSWAC). The NNSSWAC provides the requirements, terms, and conditions under which the Nevada National Security Site (NNSS) will accept low-level radioactive waste and mixed low-level waste for disposal. The NNSSWAC includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NNSS Area 3 and Area 5 Radioactive Waste Management Complex for disposal. The NNSA/NSO and support contractors are available to assist you in understanding or interpreting this document. For assistance, please call the NNSA/NSO Waste Management Project at (702) 295-7063 or fax to (702) 295-1153.

  10. Idaho CERCLA Disposal Facility Complex Waste Acceptance Criteria

    SciTech Connect

    W. Mahlon Heileson

    2006-10-01

    The Idaho Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Disposal Facility (ICDF) has been designed to accept CERCLA waste generated within the Idaho National Laboratory. Hazardous, mixed, low-level, and Toxic Substance Control Act waste will be accepted for disposal at the ICDF. The purpose of this document is to provide criteria for the quantities of radioactive and/or hazardous constituents allowable in waste streams designated for disposal at ICDF. This ICDF Complex Waste Acceptance Criteria is divided into four section: (1) ICDF Complex; (2) Landfill; (3) Evaporation Pond: and (4) Staging, Storage, Sizing, and Treatment Facility (SSSTF). The ICDF Complex section contains the compliance details, which are the same for all areas of the ICDF. Corresponding sections contain details specific to the landfill, evaporation pond, and the SSSTF. This document specifies chemical and radiological constituent acceptance criteria for waste that will be disposed of at ICDF. Compliance with the requirements of this document ensures protection of human health and the environment, including the Snake River Plain Aquifer. Waste placed in the ICDF landfill and evaporation pond must not cause groundwater in the Snake River Plain Aquifer to exceed maximum contaminant levels, a hazard index of 1, or 10-4 cumulative risk levels. The defined waste acceptance criteria concentrations are compared to the design inventory concentrations. The purpose of this comparison is to show that there is an acceptable uncertainty margin based on the actual constituent concentrations anticipated for disposal at the ICDF. Implementation of this Waste Acceptance Criteria document will ensure compliance with the Final Report of Decision for the Idaho Nuclear Technology and Engineering Center, Operable Unit 3-13. For waste to be received, it must meet the waste acceptance criteria for the specific disposal/treatment unit (on-Site or off-Site) for which it is destined.

  11. Acceptance Criteria Framework for Autonomous Biological Detectors

    SciTech Connect

    Dzenitis, J M

    2006-12-12

    The purpose of this study was to examine a set of user acceptance criteria for autonomous biological detection systems for application in high-traffic, public facilities. The test case for the acceptance criteria was the Autonomous Pathogen Detection System (APDS) operating in high-traffic facilities in New York City (NYC). However, the acceptance criteria were designed to be generally applicable to other biological detection systems in other locations. For such detection systems, ''users'' will include local authorities (e.g., facility operators, public health officials, and law enforcement personnel) and national authorities [including personnel from the Department of Homeland Security (DHS), the BioWatch Program, the Centers for Disease Control and Prevention (CDC), and the Federal Bureau of Investigation (FBI)]. The panel members brought expertise from a broad range of backgrounds to complete this picture. The goals of this document are: (1) To serve as informal guidance for users in considering the benefits and costs of these systems. (2) To serve as informal guidance for developers in understanding the needs of users. In follow-up work, this framework will be used to systematically document the APDS for appropriateness and readiness for use in NYC.

  12. Nevada National Security Site Waste Acceptance Criteria

    SciTech Connect

    none,

    2013-06-01

    This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO), Nevada National Security Site Waste Acceptance Criteria (NNSSWAC). The NNSSWAC provides the requirements, terms, and conditions under which the Nevada National Security Site (NNSS) will accept the following: • DOE hazardous and non-hazardous non-radioactive classified waste • DOE low-level radioactive waste (LLW) • DOE mixed low-level waste (MLLW) • U.S. Department of Defense (DOD) classified waste The LLW and MLLW listed above may also be classified waste. Classified waste is the only waste accepted for disposal that may be non-radioactive and shall be required to meet the waste acceptance criteria for radioactive waste as specified in this document. Classified waste may be sent to the NNSS as classified matter. Section 3.1.18 provides the requirements that must be met for permanent burial of classified matter. The NNSA/NFO and support contractors are available to assist the generator in understanding or interpreting this document. For assistance, please call the NNSA/NFO Environmental Management Operations (EMO) at (702) 295-7063, and the call will be directed to the appropriate contact.

  13. Nevada National Security Site Waste Acceptance Criteria

    SciTech Connect

    NSTec Environmental Management

    2012-02-28

    This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO), Nevada National Security Site Waste Acceptance Criteria (NNSSWAC). The NNSSWAC provides the requirements, terms, and conditions under which the Nevada National Security Site (NNSS) will accept DOE non-radioactive classified waste, DOE non-radioactive hazardous classified waste, DOE low-level radioactive waste (LLW), DOE mixed low-level waste (MLLW), and U.S. Department of Defense (DOD) classified waste for permanent disposal. Classified waste is the only waste accepted for disposal that may be non-radioactive and will be required to meet the waste acceptance criteria for radioactive waste as specified in this document. The NNSA/NSO and support contractors are available to assist you in understanding or interpreting this document. For assistance, please call the NNSA/NSO Waste Management Project (WMP) at (702) 295-7063, and your call will be directed to the appropriate contact.

  14. STOL ride quality criteria - Passenger acceptance.

    NASA Technical Reports Server (NTRS)

    Jacobson, I. D.; Kuhlthau, A. R.

    1972-01-01

    The ability to mathematically model human reaction to variables involved in transportation systems offers a very desirable tool both for the prediction of passenger acceptance of proposed systems, and for establishing acceptance criteria for the system designer. As a first step in the development of a general model for STOL systems, a mathematical formulation is presented which accepts as inputs nine variables felt to be important in flight under STOL-type conditions and presents an index of human response as the output. The variables used are three linear motions, three angular motions, pressure, temperature and noise level. The results are used to establish specifications for stability augmentation systems to improve the ride quality of existing STOL aircraft.

  15. Development of quantitative risk acceptance criteria

    SciTech Connect

    Griesmeyer, J. M.; Okrent, D.

    1981-01-01

    Some of the major considerations for effective management of risk are discussed, with particular emphasis on risks due to nuclear power plant operations. Although there are impacts associated with the rest of the fuel cycle, they are not addressed here. Several previously published proposals for quantitative risk criteria are reviewed. They range from a simple acceptance criterion on individual risk of death to a quantitative risk management framework. The final section discussed some of the problems in the establishment of a framework for the quantitative management of risk.

  16. Establishing seismic design criteria to achieve an acceptable seismic margin

    SciTech Connect

    Kennedy, R.P.

    1997-01-01

    In order to develop a risk based seismic design criteria the following four issues must be addressed: (1) What target annual probability of seismic induced unacceptable performance is acceptable? (2). What minimum seismic margin is acceptable? (3) Given the decisions made under Issues 1 and 2, at what annual frequency of exceedance should the Safe Shutdown Earthquake ground motion be defined? (4) What seismic design criteria should be established to reasonably achieve the seismic margin defined under Issue 2? The first issue is purely a policy decision and is not addressed in this paper. Each of the other three issues are addressed. Issues 2 and 3 are integrally tied together so that a very large number of possible combinations of responses to these two issues can be used to achieve the target goal defined under Issue 1. Section 2 lays out a combined approach to these two issues and presents three potentially attractive combined resolutions of these two issues which reasonably achieves the target goal. The remainder of the paper discusses an approach which can be used to develop seismic design criteria aimed at achieving the desired seismic margin defined in resolution of Issue 2. Suggestions for revising existing seismic design criteria to more consistently achieve the desired seismic margin are presented.

  17. Defining the criteria for identifying constitutional epimutations.

    PubMed

    Sloane, Mathew A; Ward, Robyn L; Hesson, Luke B

    2016-01-01

    In the January 2016 issue of Clinical Epigenetics, Quiñonez-Silva et al. (Clin Epigenetics 8:1, 2016) described a possible constitutional epimutation of the RB1 gene as a cause of hereditary predisposition to retinoblastoma. The term constitutional epimutation describes an epigenetic aberration in normal tissues that predisposes to disease. The data presented by Quiñonez-Silva et al. are interesting, but further analysis is required to demonstrate a constitutional epimutation in this family. Here, we define the criteria and describe the experimental approach necessary to identify an epigenetic aberration as a constitutional epimutation. PMID:27096027

  18. Steam generator tube integrity flaw acceptance criteria

    SciTech Connect

    Cochet, B.

    1997-02-01

    The author discusses the establishment of a flaw acceptance criteria with respect to flaws in steam generator tubing. The problem is complicated because different countries take different approaches to the problem. The objectives in general are grouped in three broad areas: to avoid the unscheduled shutdown of the reactor during normal operation; to avoid tube bursts; to avoid excessive leak rates in the event of an accidental overpressure event. For each degradation mechanism in the tubes it is necessary to know answers to an array of questions, including: how well does NDT testing perform against this problem; how rapidly does such degradation develop; how well is this degradation mechanism understood. Based on the above information it is then possible to come up with a policy to look at flaw acceptance. Part of this criteria is a schedule for the frequency of in-service inspection and also a policy for when to plug flawed tubes. The author goes into a broad discussion of each of these points in his paper.

  19. Waste acceptance criteria for closure generated waste

    SciTech Connect

    Not Available

    1992-05-01

    The PORTS Facility has been operating since 1954. The PORTS Facility is used to enrich uranium for nuclear navy applications and commercial nuclear reactors. The PORTS process uses molecular diffusion techniques to separate the U-235 isotope from the U-238 isotope. The PORTS Facility consists of a complex cascade of compressors and converters through which gaseous uranium hexafluoride feed is processed. The feed contains approximately 0.7 percent U-235 by weight while products contain from 4 to 97 percent U-235 by weight, depending on the final application. In general, the majority of the closure wastes generated at PORTS consists of personal protective equipment (PPE), rags, soils, decontamination solutions, and construction related debris. These hazardous wastes will be predominately characterized on the basis of process knowledge. PORTS assumes its conservative waste characterizations that are based on process knowledge are correct unless and until further investigation and/or analysis proves the constituents are not present or are present at concentrations below characteristic regulatory thresholds. Waste Acceptance Criteria for wastes generated by the closure of active and inactive RCRA facilities at PORTS has been developed. The criteria presented in this document govern the activities that are performed during the closure and subsequent generation of waste and relocation from the closure locations to the storage unit. These criteria are intended to ensure the proper handling, classification, processing, and storage of wastes in order to prevent hazardous waste release that may pose a threat to human health or the environment. Any wastes currently stored at each of the facilities that are to be closed will be transferred to the X-326 or X-7725 Storage Units. The waste transfers will be accomplished in accordance with the Container Transfer Plan.

  20. Structural acceptance criteria Remote Handling Building Tritium Extraction Facility

    SciTech Connect

    Mertz, G.

    1999-12-16

    This structural acceptance criteria contains the requirements for the structural analysis and design of the Remote Handling Building (RHB) in the Tritium Extraction Facility (TEF). The purpose of this acceptance criteria is to identify the specific criteria and methods that will ensure a structurally robust building that will safely perform its intended function and comply with the applicable Department of Energy (DOE) structural requirements.

  1. Nevada Test Site Waste Acceptance Criteria, December 2000

    SciTech Connect

    2000-12-01

    This document establishes the US Department of Energy, Nevada Operations Office waste acceptance criteria. The waste acceptance criteria provides the requirements, terms, and conditions under which the Nevada Test Site will accept low-level radioactive waste and mixed waste for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the Nevada Test Site Area 3 and Area 5 Radioactive Waste Management Sites for storage or disposal.

  2. Heat exchanger, head and shell acceptance criteria

    SciTech Connect

    Lam, P.S.; Sindelar, R.L.

    1992-09-01

    Instability of postulated flaws in the head component of the heat exchanger could not produce a large break, equivalent to a DEGB in the PWS piping, due to the configuration of the head and restraint provided by the staybolts. Rather, leakage from throughwall flaws in the head would increase with flaw length with finite leakage areas that are bounded by a post-instability flaw configuration. Postulated flaws at instability in the shell of the heat exchanger or in the cooling water nozzles could produce a large break in the Cooling Water System (CWS) pressure boundary. An initial analysis of flaw stability for postulated flaws in the heat exchanger head was performed in January 1992. This present report updates that analysis and, additionally, provides acceptable flaw configurations to maintain defined structural or safety margins against flaw instability of the external pressure boundary components of the heat exchanger, namely the head, shell, and cooling water nozzles. Structural and flaw stability analyses of the heat exchanger tubes, the internal pressure boundary of the heat exchangers or interface boundary between the PWS and CWS, were previously completed in February 1992 as part of the heat exchanger restart evaluation and are not covered in this report.

  3. 49 CFR 173.57 - Acceptance criteria for new explosives.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Acceptance criteria for new explosives. 173.57... § 173.57 Acceptance criteria for new explosives. (a) Unless otherwise excepted, an explosive substance... the Small-Scale Burning Test (Test Method 3(d)(i)), each as described in the Explosive Test Manual...

  4. Human factors engineering design review acceptance criteria for the safety parameter display

    SciTech Connect

    McGevna, V.; Peterson, L.R.

    1981-10-02

    This report contains human factors engineering design review acceptance criteria developed by the Human Factors Engineering Branch (HFEB) of the Nuclear Regulatory Commission (NRC) to use in evaluating designs of the Safety Parameter Display System (SPDS). These criteria were developed in response to the functional design criteria for the SPDS defined in NUREG-0696, Functional Criteria for Emergency Response Facilities. The purpose of this report is to identify design review acceptance criteria for the SPDS installed in the control room of a nuclear power plant. Use of computer driven cathode ray tube (CRT) displays is anticipated. General acceptance criteria for displays of plant safety status information by the SPDS are developed. In addition, specific SPDS review criteria corresponding to the SPDS functional criteria specified in NUREG-0696 are established.

  5. Nevada Test Site Waste Acceptance Criteria

    SciTech Connect

    U.S. Department of Energy, Nevada Operations Office, Waste Acceptance Criteria

    1999-05-01

    This document provides the requirements, terms, and conditions under which the Nevada Test Site will accept low-level radioactive and mixed waste for disposal; and transuranic and transuranic mixed waste for interim storage at the Nevada Test Site.

  6. Nevada test site waste acceptance criteria

    SciTech Connect

    1996-09-01

    This document provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive and mixed waste for disposal; and transuranic and transuranic mixed waste for interim storage at the NTS. Review each section of this document. This document is not intended to include all of the requirements; rather, it is meant as a guide toward meeting the regulations. All references in this document should be observed to avoid omission of requirements on which acceptance or rejection of waste will be based. The Department of Energy/Nevada Operations Office (DOE/NV) and support contractors are available to assist you in understanding or interpreting this document.

  7. Community acceptance of helicopter noise: Criteria and application

    NASA Technical Reports Server (NTRS)

    Munch, C. L.; King, R. J.

    1974-01-01

    A study was conducted to define those criteria necessary for civil helicopter operations to be acoustically acceptable to the communities from which they operate and over which they fly. The study involved surveying existing domestic and foreign Federal regulations and guidelines, state and local noise ordinances, results of community noise annoyance studies, and results of individual aircraft noise annoyance studies, and results of individual aircraft noise annoyance studies in order to establish the criteria. The final criteria selection are based on the Day-Night Level, L sub DN, a measure of total noise exposure. The basic rating unit is the A weighted sound pressure level (dbA) which has accuracy comparable to other units currently used for aircraft. An L sub DN of 60 is recommended as a criterion for areas where the ambient noise is below 58 dbA. An L sub DN value 2 dbA above the local ambient is recommended for areas where the ambient is above 58 dbA.

  8. Acceptance criteria for risk in offshore construction projects

    SciTech Connect

    Rettedal, W.; Gudmestad, O.T.

    1995-12-31

    The Norwegian Petroleum Directorate (NPD) state in their Regulation for Risk Analysis that the Operator shall form the acceptance criteria for the risk analysis. This applies to both the construction and operating phases. The philosophy is that the risk should be kept as low as reasonable practicable (ALARP). This paper will discuss what form the criteria for an offshore construction project should have, what hazards the criteria should be measured against and how one should proceed to obtain acceptable risk levels. An application of the criteria for an offshore construction project will be discussed.

  9. Acceptance criteria considerations for miscellaneous wastes

    SciTech Connect

    Irvine, A.R.; Forsberg, C.W.

    1987-01-01

    EPA standards set forth limitations regarding releases to the accessible environment adjacent to a geologic repository. The NRC criteria pertaining to waste form and engineered barrier performance place certain restrictions on the physical and chemical nature of the waste form and require substantially complete confinement of radioactivity until the high-heat-production period is past. After this period, the annual release of radionuclides from the waste package is normally limited to 1 part in 100,000 of the amounts calculated to be present at 1000-y decay. The regulation permits deviation from these criteria in exceptional circumstances. One such circumstance might be the absence of a significant perturbation in temperature around the stored waste. The lack of significant heat release will eliminate the hydrologic driving force for dispersal of radionuclides. Exceptional circumstances which potentially could justify a less stringent long-term release criterion are: small quantity of radioactivity, the nature of the radioactive species, and the nature of the geology in which the waste is to be emplaced. Because the MW after a suitable decay period have low heat release rates per unit volume, they apparently could be so emplaced in a repository that there would be no compelling need, according to the reasoning presented in 10 CFR 60, for a 1000-y container. Regarding attainment of the specified long-term release rate criterion, neither the solubility limits for the various waste forms nor the conductance of potential migration barriers are currently adequately characterized. The relatively small total heat generation rate for the MW in combination with the usual low volumetric heat generation rate apparently will allow application of migration barriers in a low temperature environment where barrier performance would be expected to be unchanged with time.

  10. NEVADA TEST SITE WASTE ACCEPTANCE CRITERIA, JUNE 2006

    SciTech Connect

    U.S. DEPARTMENT OF ENERGY, NATIONAL NUCLEAR SECURITY ADMINISTRATION NEVADA SITE OFFICE

    2006-06-01

    This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive (LLW) and mixed waste (MW) for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex (RWMC) for storage or disposal.

  11. Waste-acceptance criteria for radioactive waste disposal

    SciTech Connect

    Gilbert, T.L.; Meshkov, N.K.

    1987-02-01

    A method has been developed for establishing waste-acceptance criteria based on quantitative performance factors that characterize the confinement capabilities of a disposal facility for radioactive waste. The method starts from the objective of protecting public health and safety by assuring that disposal of the waste will not result in a radiation dose of any member of the general public, in either the short or long term, in excess of an established basic dose limit. A key aspect of the method is the introduction of a confinement factor that characterizes the overall confinement capability of a particular disposal facility and can be used for quantitative performance assessments as well as for establishing facility-specific waste-acceptance criteria. Confinement factors enable direct and simple conversion of a basic dose limit into waste-acceptance criteria, specified as concentration limits on rationuclides in the waste streams. Waste-acceptance criteria can be represented visually as activity/time plots for various waste streams. These plots show the concentrations of radionuclides in a waste stream as a function of time and permit a visual, quantitative assessment of long-term performance, relative risks from different radionuclides in the waste stream, and contributions from ingrowth. Application of the method to generic facility designs provides a radional basis for a waste classification system. 14 refs.

  12. MCO combustible gas management leak test acceptance criteria

    SciTech Connect

    SHERRELL, D.L.

    1999-05-11

    Existing leak test acceptance criteria for mechanically sealed and weld sealed multi-canister overpacks (MCO) were evaluated to ensure that MCOs can be handled and stored in stagnant air without compromising the Spent Nuclear Fuel Project's overall strategy to prevent accumulation of combustible gas mixtures within MCO's or within their surroundings. The document concludes that the integrated leak test acceptance criteria for mechanically sealed and weld sealed MCOs (1 x 10{sup -5} std cc/sec and 1 x 10{sup -7} std cc/sec, respectively) are adequate to meet all current and foreseeable needs of the project, including capability to demonstrate compliance with the NFPA 60 Paragraph 3-3 requirement to maintain hydrogen concentrations [within the air atmosphere CSB tubes] t or below 1 vol% (i.e., at or below 25% of the LFL).

  13. Procedures and acceptance criteria for PAS-1 cask inspections

    SciTech Connect

    Mercado, J.E.

    1998-09-09

    The procedures and acceptance criteria that comprise this document were prepared to support a one-time test to certify two PAS-1 casks in accordance with US Department of Energy Certificate of Compliance US A/9184/B(U), which was issued in 1998. The specific inspections addressed in this document are the visual weld inspection and a dimensional inspection of the primary containment vessel.

  14. Waste-acceptance criteria for greater-confinement disposal

    SciTech Connect

    Gilbert, T.L.; Meshkov, N.K.

    1986-01-01

    A methodology for establishing waste-acceptance criteria based on quantitative performance factors that characterize the confinement capabilities of a waste-disposal site and facility has been developed. The methodology starts from the basic objective of protecting public health and safety by providing assurance that dispsoal of the waste will not result in a radiation dose to any member of the general public, in either the short or long term, in excess of an established basic dose limit. The method is based on an explicit, straightforward, and quantitative relationship among individual risk, confinement capabilities, and waste characteristics. A key aspect of the methodology is the introduction of a confinement factor that characterizes the overall confinement capability of a particular facility and can be used for quantitative assessments of the performance of different disposal sites and facilities, as well as for establishing site-specific waste-acceptance criteria. Confinement factors are derived by means of site-specific pathway analyses. They make possible a direct and simple conversion of a basic dose limit into waste-acceptance criteria, specified as concentration limits on radionuclides in the waste streams and expressed in quantitative form as a function of parameters that characterize the site, facility design, waste containers, and waste form. Waste-acceptance criteria can be represented visually as activity/time plots for various waste streams. These plots show the concentrations of radionuclides in a waste stream as a function of time and permit a visual, quantitative assessment of long-term performance, relative risks from different radionuclides in the waste stream, and contributions from ingrowth. 13 refs.

  15. Development on inelastic analysis acceptance criteria for radioactive material transportation packages

    SciTech Connect

    Ammerman, D.J.; Ludwigsen, J.S.

    1995-12-31

    The response of radioactive material transportation packages to mechanical accident loadings can be more accurately characterized by non-linear dynamic analysis than by the ``Equivalent dynamic`` static elastic analysis typically used in the design of these packages. This more accurate characterization of the response can lead to improved package safety and design efficiency. For non-linear dynamic analysis to become the preferred method of package design analysis, an acceptance criterion must be established that achieves an equivalent level of safety as the currently used criterion defined in NRC Regulatory Guide 7.6 (NRC 1978). Sandia National Laboratories has been conducting a study of possible acceptance criteria to meet this requirement. In this paper non-linear dynamic analysis acceptance criteria based on stress, strain, and strain-energy-density will be discussed. An example package design will be compared for each of the design criteria, including the approach of NRC Regulatory Guide 7.6.

  16. 24 CFR 203.202 - Plan acceptability and acceptance renewal criteria-general.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... renewal criteria-general. 203.202 Section 203.202 Housing and Urban Development Regulations Relating to... initiation of sanctions against a Plan issuer or insurance backer, in accordance with 2 CFR part 2424. If HUD..., and the procedural safeguards of 2 CFR part 2424 will apply. (c) Unless renewed, Plan acceptance...

  17. 24 CFR 203.202 - Plan acceptability and acceptance renewal criteria-general.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... renewal criteria-general. 203.202 Section 203.202 Housing and Urban Development Regulations Relating to... initiation of sanctions against a Plan issuer or insurance backer, in accordance with 2 CFR part 2424. If HUD..., and the procedural safeguards of 2 CFR part 2424 will apply. (c) Unless renewed, Plan acceptance...

  18. 24 CFR 203.202 - Plan acceptability and acceptance renewal criteria-general.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... renewal criteria-general. 203.202 Section 203.202 Housing and Urban Development Regulations Relating to... initiation of sanctions against a Plan issuer or insurance backer, in accordance with 2 CFR part 2424. If HUD..., and the procedural safeguards of 2 CFR part 2424 will apply. (c) Unless renewed, Plan acceptance...

  19. Identifying Minimally Acceptable Interpretive Performance Criteria for Screening Mammography1

    PubMed Central

    Sickles, Edward A.; Monsees, Barbara S.; Bassett, Lawrence W.; Brenner, R. James; Feig, Stephen A.; Smith, Robert A.; Rosenberg, Robert D.; Bogart, T. Andrew; Browning, Sally; Barry, Jane W.; Kelly, Mary M.; Tran, Khai A.; Miglioretti, Diana L.

    2010-01-01

    Purpose: To develop criteria to identify thresholds for minimally acceptable physician performance in interpreting screening mammography studies and to profile the impact that implementing these criteria may have on the practice of radiology in the United States. Materials and Methods: In an institutional review board–approved, HIPAA-compliant study, an Angoff approach was used in two phases to set criteria for identifying minimally acceptable interpretive performance at screening mammography as measured by sensitivity, specificity, recall rate, positive predictive value (PPV) of recall (PPV1) and of biopsy recommendation (PPV2), and cancer detection rate. Performance measures were considered separately. In phase I, a group of 10 expert radiologists considered a hypothetical pool of 100 interpreting physicians and conveyed their cut points of minimally acceptable performance. The experts were informed that a physician’s performance falling outside the cut points would result in a recommendation to consider additional training. During each round of scoring, all expert radiologists’ cut points were summarized into a mean, median, mode, and range; these were presented back to the group. In phase II, normative data on performance were shown to illustrate the potential impact cut points would have on radiology practice. Rescoring was done until consensus among experts was achieved. Simulation methods were used to estimate the potential impact of performance that improved to acceptable levels if effective additional training was provided. Results: Final cut points to identify low performance were as follows: sensitivity less than 75%, specificity less than 88% or greater than 95%, recall rate less than 5% or greater than 12%, PPV1 less than 3% or greater than 8%, PPV2 less than 20% or greater than 40%, and cancer detection rate less than 2.5 per 1000 interpretations. The selected cut points for performance measures would likely result in 18%–28% of interpreting

  20. Establishment of noise acceptance criteria for wind turbines

    NASA Technical Reports Server (NTRS)

    Stephens, D. G.; Shepherd, K. P.; Grosveld, F.

    1981-01-01

    A program is being conducted to develop noise criteria for wind turbines which minimize annoyance and which can be used in design specifications for future machines. The approach consists of presenting wind turbine noise stimuli to test subjects in a laboratory listening chamber. The responses of the subjects are recorded for a range of stimuli which encompass the designs, operating conditions, and ambient noise levels of current and future installations. Results to date have established the threshold of detectability for a range of impulsive stimuli of the type associated with blade/tower-wake interactions. The status of the ongoing psychoacoustic tests, the subjective data, and the approach to the development of noise acceptance criteria are described.

  1. Waste acceptance criteria for the Waste Isolation Pilot Plant

    SciTech Connect

    1996-04-01

    The Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria (WAC), DOE/WIPP-069, was initially developed by a U.S. Department of Energy (DOE) Steering Committee to provide performance requirements to ensure public health and safety as well as the safe handling of transuranic (TRU) waste at the WIPP. This revision updates the criteria and requirements of previous revisions and deletes those which were applicable only to the test phase. The criteria and requirements in this document must be met by participating DOE TRU Waste Generator/Storage Sites (Sites) prior to shipping contact-handled (CH) and remote-handled (RH) TRU waste forms to the WIPP. The WIPP Project will comply with applicable federal and state regulations and requirements, including those in Titles 10, 40, and 49 of the Code of Federal Regulations (CFR). The WAC, DOE/WIPP-069, serves as the primary directive for assuring the safe handling, transportation, and disposal of TRU wastes in the WIPP and for the certification of these wastes. The WAC identifies strict requirements that must be met by participating Sites before these TRU wastes may be shipped for disposal in the WIPP facility. These criteria and requirements will be reviewed and revised as appropriate, based on new technical or regulatory requirements. The WAC is a controlled document. Revised/changed pages will be supplied to all holders of controlled copies.

  2. [Ethics in organ transplantation: continous search for defining what is acceptable].

    PubMed

    Reyes-Acevedo, Rafael

    2005-01-01

    In the past 50 years, Transplant Medicine has been adopted worldwide as a growing option for treatment of many organic diseases. Ethical Issues in organ replacement therapy have emerged since the beginning. Significant advancements in the care of critically ill patients, as well as the increasing need of cadaveric organs for transplantation, definitively influenced a complex discussion about new criteria for definition of death, one of the most complex ethic debates in last century. Criteria for organ assignment are also cause of profound debate, especially when the number of patients waiting for an organ is extremely high compared with organ availability. Living donor represents a very complex figure in modern medicine, security issues as well as the need to offer them absolute respect to their capacity to decide must be considered in every patient. Ethics in transplantation represent a continuous search for defining what is acceptable.

  3. Radioactive waste acceptance team and generator interface yields successful implementation of waste acceptance criteria

    SciTech Connect

    Rowe, J.G.; Griffin, W.A.; Rast, D.M.

    1996-02-01

    The Fernald Environmental Management Project has developed a successful Low Level Waste Shipping Program in compliance with the Nevada Test Site Defense Waste Acceptance Criteria, Certification, and Transfer Requirements, NVO-325, Revision 1. This shipping program is responsible for the successful disposal of more than 4 million cubic feet of Low Level Waste over the past decade. The success of the Fernald Low Level Waste Shipping Program is due to the generator program staff working closely with the DOE-NV Radioactive Waste Acceptance Program Team to achieve win/win situations. The teamwork is the direct result of dedicated, proactive professionals working together toward a common objective: the safe disposition of low level radioactive waste. The growth and development of this program has many lessons learned to share with the low level waste generating community. The recognition of reciprocal interests enables consistently high annual volumes of Fernald waste disposal at the Nevada Test Site without incident. The large volumes successfully disposed serve testimony to the success of the program which is equally important to all Nevada Test Site and Fernald stakeholders. The Fernald approach to success is currently being shared with other low-level waste generators through DOE-NV sponsored outreach programs. This paper introduces examples of Fernald Environmental Restoration Management Corporation contributions to the DOE-NV Radioactive Waste Acceptance Program outreach initiatives. These practices are applicable to other low level waste disposal programs whether federal, commercial, domestic or international.

  4. 7 CFR 42.107 - Lot acceptance criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... acceptance (Ac) and rejection (Re) numbers in the sampling plan. (1) Accept the lot after examining the...) The number of critical defects does not exceed the applicable acceptance number (Ac) for critical defects, and (ii) The number of major defects does not exceed the applicable acceptance number (Ac)...

  5. Data Quality Objectives for WTP Feed Acceptance Criteria - 12043

    SciTech Connect

    Arakali, Aruna V.; Benson, Peter A.; Duncan, Garth; Johnston, Jill C.; Lane, Thomas A.; Matis, George; Olson, John W.; Banning, Davey L.; Greer, Daniel A.; Seidel, Cary M.; Thien, Michael G.

    2012-07-01

    The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is under construction for the U.S. Department of Energy by Bechtel National, Inc. and subcontractor URS Corporation (contract no. DE-AC27-01RV14136). The plant when completed will be the world's largest nuclear waste treatment facility. Bechtel and URS are tasked with designing, constructing, commissioning, and transitioning the plant to the long term operating contractor to process the legacy wastes that are stored in underground tanks (from nuclear weapons production between the 1940's and the 1980's). Approximately 56 million gallons of radioactive waste is currently stored in these tanks at the Hanford Site in southeastern Washington. There are three major WTP facilities being constructed for processing the tank waste feed. The Pretreatment (PT) facility receives feed where it is separated into a low activity waste (LAW) fraction and a high level waste (HLW) fraction. These fractions are transferred to the appropriate (HLW or LAW) facility, combined with glass former material, and sent to high temperature melters for formation of the glass product. In addition to PT, HLW and LAW, other facilities in WTP include the Laboratory (LAB) for analytical services and the Balance of Facilities (BOF) for plant maintenance, support and utility services. The transfer of staged feed from the waste storage tanks and acceptance in WTP receipt vessels require data for waste acceptance criteria (WAC) parameters from analysis of feed samples. The Data Quality Objectives (DQO) development was a joint team effort between WTP and Tank Operations Contractor (TOC) representatives. The focus of this DQO effort was to review WAC parameters and develop data quality requirements, the results of which will determine whether or not the staged feed can be transferred from the TOC to WTP receipt vessels. The approach involved systematic planning for data collection consistent with EPA guidance for the seven-step DQO process

  6. 46 CFR 54.05-17 - Weld toughness test acceptance criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PRESSURE VESSELS Toughness Tests § 54.05-17 Weld toughness test acceptance criteria. (a) For Charpy V-notch impact tests the energy absorbed in both the weld metal and heat affected zone impact tests in weld... 46 Shipping 2 2010-10-01 2010-10-01 false Weld toughness test acceptance criteria....

  7. 48 CFR 15.607 - Criteria for acceptance and negotiation of an unsolicited proposal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Criteria for acceptance... System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 15.607 Criteria for acceptance and negotiation of an unsolicited proposal. (a)...

  8. 48 CFR 915.607 - Criteria for acceptance and negotiation of an unsolicited proposal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Criteria for acceptance... System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 915.607 Criteria for acceptance and negotiation of an unsolicited proposal. (c) DOE's...

  9. Methods for verifying compliance with low-level radioactive waste acceptance criteria

    SciTech Connect

    1993-09-01

    This report summarizes the methods that are currently employed and those that can be used to verify compliance with low-level radioactive waste (LLW) disposal facility waste acceptance criteria (WAC). This report presents the applicable regulations representing the Federal, State, and site-specific criteria for accepting LLW. Typical LLW generators are summarized, along with descriptions of their waste streams and final waste forms. General procedures and methods used by the LLW generators to verify compliance with the disposal facility WAC are presented. The report was written to provide an understanding of how a regulator could verify compliance with a LLW disposal facility`s WAC. A comprehensive study of the methodology used to verify waste generator compliance with the disposal facility WAC is presented in this report. The study involved compiling the relevant regulations to define the WAC, reviewing regulatory agency inspection programs, and summarizing waste verification technology and equipment. The results of the study indicate that waste generators conduct verification programs that include packaging, classification, characterization, and stabilization elements. The current LLW disposal facilities perform waste verification steps on incoming shipments. A model inspection and verification program, which includes an emphasis on the generator`s waste application documentation of their waste verification program, is recommended. The disposal facility verification procedures primarily involve the use of portable radiological survey instrumentation. The actual verification of generator compliance to the LLW disposal facility WAC is performed through a combination of incoming shipment checks and generator site audits.

  10. Nevada Test Site waste acceptance criteria [Revision 1

    SciTech Connect

    1997-08-01

    Revision one updates the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive and mixed waste for disposal; and transuranic and transuranic mixed waste for interim storage at the NTS. Review each section of this document. This document is not intended to include all of the requirements; rather, it is meant as a guide toward meeting the regulations. All references in this document should be observed to avoid omission of requirements on which acceptance or rejection of waste will be based. The Department of Energy/Nevada Operations Office (DOE/NV) and support contractors are available to assist you in understanding or interpreting this document.

  11. 44 CFR 362.3 - Criteria for determining acceptance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... gift of services is offered to the Administrator for the benefit of the National Earthquake Hazards Reduction Program. (a) The gift of property or gift of services must clearly and directly further the objectives of the National Earthquake Hazards Reduction Program, as defined in 42 U.S.C. 7702. (b) All...

  12. 44 CFR 362.3 - Criteria for determining acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... gift of services is offered to the Administrator for the benefit of the National Earthquake Hazards Reduction Program. (a) The gift of property or gift of services must clearly and directly further the objectives of the National Earthquake Hazards Reduction Program, as defined in 42 U.S.C. 7702. (b) All...

  13. 44 CFR 362.3 - Criteria for determining acceptance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... gift of services is offered to the Administrator for the benefit of the National Earthquake Hazards Reduction Program. (a) The gift of property or gift of services must clearly and directly further the objectives of the National Earthquake Hazards Reduction Program, as defined in 42 U.S.C. 7702. (b) All...

  14. 44 CFR 362.3 - Criteria for determining acceptance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... gift of services is offered to the Administrator for the benefit of the National Earthquake Hazards Reduction Program. (a) The gift of property or gift of services must clearly and directly further the objectives of the National Earthquake Hazards Reduction Program, as defined in 42 U.S.C. 7702. (b) All...

  15. 44 CFR 362.3 - Criteria for determining acceptance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... gift of services is offered to the Administrator for the benefit of the National Earthquake Hazards Reduction Program. (a) The gift of property or gift of services must clearly and directly further the objectives of the National Earthquake Hazards Reduction Program, as defined in 42 U.S.C. 7702. (b) All...

  16. Example Procedures for Developing Acceptance-Range Criteria for BESTEST-EX

    SciTech Connect

    Judkoff, R.; Polly, B.; Bianchi, M.; Neymark, J.

    2010-08-01

    This document provides an example procedure for establishing acceptance-range criteria to assess results from software undergoing BESTEST-EX. This example method for BESTEST-EX is a modified version of the method described in HERS BESTEST.

  17. Defining safe criteria to diagnose miscarriage: prospective observational multicentre study

    PubMed Central

    Preisler, Jessica; Kopeika, Julia; Ismail, Laure; Vathanan, Veluppillai; Farren, Jessica; Abdallah, Yazan; Battacharjee, Parijat; Van Holsbeke, Caroline; Bottomley, Cecilia; Gould, Deborah; Johnson, Susanne; Stalder, Catriona; Van Calster, Ben; Hamilton, Judith; Timmerman, Dirk

    2015-01-01

    Objectives To validate recent guidance changes by establishing the performance of cut-off values for embryo crown-rump length and mean gestational sac diameter to diagnose miscarriage with high levels of certainty. Secondary aims were to examine the influence of gestational age on interpretation of mean gestational sac diameter and crown-rump length values, determine the optimal intervals between scans and findings on repeat scans that definitively diagnose pregnancy failure.) Design Prospective multicentre observational trial. Setting Seven hospital based early pregnancy assessment units in the United Kingdom. Participants 2845 women with intrauterine pregnancies of unknown viability included if transvaginal ultrasonography showed an intrauterine pregnancy of uncertain viability. In three hospitals this was initially defined as an empty gestational sac <20 mm mean diameter with or without a visible yolk sac but no embryo, or an embryo with crown-rump length <6 mm with no heartbeat. Following amended guidance in December 2011 this definition changed to a gestational sac size <25 mm or embryo crown-rump length <7 mm. At one unit the definition was extended throughout to include a mean gestational sac diameter <30 mm or embryo crown-rump length <8 mm. Main outcome measures Mean gestational sac diameter, crown-rump length, and presence or absence of embryo heart activity at initial and repeat transvaginal ultrasonography around 7-14 days later. The final outcome was pregnancy viability at 11-14 weeks’ gestation. Results The following indicated a miscarriage at initial scan: mean gestational sac diameter ≥25 mm with an empty sac (364/364 specificity: 100%, 95% confidence interval 99.0% to 100%), embryo with crown-rump length ≥7 mm without visible embryo heart activity (110/110 specificity: 100%, 96.7% to 100%), mean gestational sac diameter ≥18 mm for gestational sacs without an embryo presenting after 70 days’ gestation (907/907 specificity: 100%, 99.6% to

  18. 10 CFR 50.46a - Acceptance criteria for reactor coolant system venting systems.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... criteria for reactor coolant system venting systems. Each nuclear power reactor must be provided with high... 10 Energy 1 2012-01-01 2012-01-01 false Acceptance criteria for reactor coolant system venting systems. 50.46a Section 50.46a Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION...

  19. 10 CFR 50.46a - Acceptance criteria for reactor coolant system venting systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... criteria for reactor coolant system venting systems. Each nuclear power reactor must be provided with high... 10 Energy 1 2011-01-01 2011-01-01 false Acceptance criteria for reactor coolant system venting systems. 50.46a Section 50.46a Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION...

  20. 10 CFR 50.46a - Acceptance criteria for reactor coolant system venting systems.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... criteria for reactor coolant system venting systems. Each nuclear power reactor must be provided with high... 10 Energy 1 2014-01-01 2014-01-01 false Acceptance criteria for reactor coolant system venting systems. 50.46a Section 50.46a Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION...

  1. 10 CFR 50.46a - Acceptance criteria for reactor coolant system venting systems.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... criteria for reactor coolant system venting systems. Each nuclear power reactor must be provided with high... 10 Energy 1 2013-01-01 2013-01-01 false Acceptance criteria for reactor coolant system venting systems. 50.46a Section 50.46a Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION...

  2. 10 CFR 50.46a - Acceptance criteria for reactor coolant system venting systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Acceptance criteria for reactor coolant system venting... criteria for reactor coolant system venting systems. Each nuclear power reactor must be provided with high point vents for the reactor coolant system, for the reactor vessel head, and for other systems...

  3. 24 CFR 203.202 - Plan acceptability and acceptance renewal criteria-general.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the Plan. (b) In evaluating applications for renewal of Plan acceptance, HUD will take into consideration such reliable evidence, as is made available to the Department, of a Plan issuer's failure to fulfill its obligations. Where HUD has credible evidence of a Plan issuer's failure to correct...

  4. 24 CFR 203.202 - Plan acceptability and acceptance renewal criteria-general.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... initiation of sanctions against a Plan issuer or insurance backer, in accordance with 2 CFR part 2424. If HUD..., and the procedural safeguards of 2 CFR part 2424 will apply. (c) Unless renewed, Plan acceptance by... accordance with 2 CFR part 2424. Insofar as practicable, HUD will respond to a Plan issuer's request...

  5. Criteria for Identifying Radiologists with Acceptable Screening Mammography Interpretive Performance based on Multiple Performance Measures

    PubMed Central

    Miglioretti, Diana L.; Ichikawa, Laura; Smith, Robert A.; Bassett, Lawrence W.; Feig, Stephen A.; Monsees, Barbara; Parikh, Jay R.; Rosenberg, Robert D.; Sickles, Edward A.; Carney, Patricia A.

    2014-01-01

    Objective Using a combination of performance measures, we updated previously proposed criteria for identifying physicians whose performance interpreting screening mammograms may indicate suboptimal interpretation skills. Materials and Methods In this Institutional Review Board-approved, HIPAA-compliant study, six expert breast imagers used a method based on the Angoff approach to update criteria for acceptable mammography performance on the basis of combined performance measures: (Group 1) sensitivity and specificity, for facilities with complete capture of false-negative cancers; and (Group 2) cancer detection rate (CDR), recall rate, and positive predictive value of a recall (PPV1), for facilities that cannot capture false negatives, but have reliable cancer follow-up information for positive mammograms. Decisions were informed by normative data from the Breast Cancer Surveillance Consortium (BCSC). Results Updated, combined ranges for acceptable sensitivity and specificity of screening mammography are: (1) sensitivity ≥80% and specificity ≥85% or (2) sensitivity 75–79% and specificity 88–97%. Updated ranges for CDR, recall rate, and PPV1 are: (1) CDR ≥6/1000, recall rate 3–20%, and any PPV1; (2) CDR 4–6/1000, recall rate 3–15%, and PPV1 ≥3%; or (3) CDR 2.5–4/1000, recall rate 5–12%, and PPV1 3–8%. Using the original criteria, 51% of BCSC radiologists had acceptable sensitivity and specificity; 40% had acceptable CDR, recall rate, and PPV1. Using the combined criteria, 69% had acceptable sensitivity and specificity and 62% had acceptable CDR, recall rate, and PPV1. Conclusion The combined criteria improve previous criteria by considering the inter-relationships of multiple performance measures and broaden the acceptable performance ranges compared to previous criteria based on individual measures. PMID:25794100

  6. A comparison and cross-reference of commercial low-level radioactive waste acceptance criteria

    SciTech Connect

    Kerr, T.A.

    1997-04-01

    This document, prepared by the National Low-Level Waste Management Program at the Idaho National Engineering and Environmental Laboratory, is a comparison and cross-reference of commercial low-level radioactive waste acceptance criteria. Many of these are draft or preliminary criteria as well as implemented criteria at operating low-level radioactive waste management facilities. Waste acceptance criteria from the following entities are included: US Nuclear Regulatory Commission, South Carolina, Washington, Utah, Nevada, California, illinois, Texas, North Carolina, Nebraska, Pennsylvania, New York, and the Midwest Compact Region. Criteria in the matrix include the following: physical form, chemical form, liquid limits, void space in packages, concentration averaging, types of packaging, chelating agents, solidification media, stability requirements, sorptive media, gas, oil, biological waste, pyrophorics, source material, special nuclear material, package dimensions, incinerator ash, dewatered resin, transuranics, and mixed waste. Each criterion in the matrix is cross-referenced to its source document so that exact requirements can be determined.

  7. Defining Acceptable Levels for Ecological Indicators: An Approach for Considering Social Values

    NASA Astrophysics Data System (ADS)

    Smyth, Robyn L.; Watzin, Mary C.; Manning, Robert E.

    2007-03-01

    Ecological indicators can facilitate an adaptive management approach, but only if acceptable levels for those indicators have been defined so that the data collected can be interpreted. Because acceptable levels are an expression of the desired state of the ecosystem, the process of establishing acceptable levels should incorporate not just ecological understanding but also societal values. The goal of this research was to explore an approach for defining acceptable levels of ecological indicators that explicitly considers social perspectives and values. We used a set of eight indicators that were related to issues of concern in the Lake Champlain Basin. Our approach was based on normative theory. Using a stakeholder survey, we measured respondent normative evaluations of varying levels of our indicators. Aggregated social norm curves were used to determine the level at which indicator values shifted from acceptable to unacceptable conditions. For seven of the eight indicators, clear preferences were interpretable from these norm curves. For example, closures of public beaches because of bacterial contamination and days of intense algae bloom went from acceptable to unacceptable at 7-10 days in a summer season. Survey respondents also indicated that the number of fish caught from Lake Champlain that could be safely consumed each month was unacceptably low and the number of streams draining into the lake that were impaired by storm water was unacceptably high. If indicators that translate ecological conditions into social consequences are carefully selected, we believe the normative approach has considerable merit for defining acceptable levels of valued ecological system components.

  8. Nevada Test Site Waste Acceptance Criteria (NTSWAC), Rev. 7-01

    SciTech Connect

    NSTec Environmental Management

    2009-05-01

    This document establishes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, Nevada Test Site Waste Acceptance Criteria (NTSWAC). The NTSWAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive waste and mixed low-level waste for disposal. The NTSWAC includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex for disposal.

  9. Waste acceptance criteria for the Waste Isolation Pilot Plant. Revision 4

    SciTech Connect

    Not Available

    1991-12-01

    This Revision 4 of the Waste Acceptance Criteria (WAC), WIPP-DOE-069, identifies and consolidates existing criteria and requirements which regulate the safe handling and preparation of Transuranic (TRU) waste packages for transportation to and emplacement in the Waste Isolation Pilot Plant (WIPP). This consolidation does not invalidate any existing certification of TRU waste to the WIPP Operations and Safety Criteria (Revision 3 of WIPP-DOE--069) and/or Transportation: Waste Package Requirements (TRUPACT-II Safety Analysis Report for Packaging [SARP]). Those documents being consolidated, including Revision 3 of the WAC, currently support the Test Phase.

  10. Acceptance criteria for determining armed response force size at nuclear power plants

    SciTech Connect

    Not Available

    1983-02-01

    This guidance document contains acceptance criteria to be used in the NRC license review process. It consists of a scored worksheet and guidelines for interpreting the worksheet score that can be used in determining the adequacy of the armed response force size at a nuclear power reactor facility.

  11. La composition academique: les limites de l'acceptabilite (Composition for Academic Purposes: Criteria for Acceptability).

    ERIC Educational Resources Information Center

    Grenall, G. M.

    1981-01-01

    Examines the pedagogical approaches and problems attendant to the development of English writing programs for foreign students. Discusses the skills necessary to handle course work, such as essay tests, term papers and reports, theses and dissertations, and focuses particularly on diagnostic problems and acceptability criteria. Societe Nouvelle…

  12. Technical Basis For Radiological Acceptance Criteria For Uranium At The Y-12 National Security Complex

    SciTech Connect

    Veinot, K. G.

    2009-07-22

    The purpose of this report is to establish radiological acceptance criteria for uranium. Other factors for acceptance not considered include criticality safety concerns, contaminants to the process stream, and impacts to the Safety Basis for the affected facilities. Three types of criteria were developed in this report. They include limits on external penetrating and non-penetrating radiation and on the internal hazard associated with inhalation of the material. These criteria are intended to alleviate the need for any special controls beyond what are normally utilized for worker protection from uranium hazards. Any proposed exceptions would require case-by-case evaluations to determine cost impacts and feasibility. Since Y-12 has set rigorous ALARA goals for worker doses, the external limits are based on assumptions of work time involved in the movement of accepted material plus the desire that external doses normally received are not exceeded, and set so that no special personnel monitoring would be required. Internal hazard controls were established so that dose contributions from non-uranium nuclides would not exceed 10% of that expected from the uranium component. This was performed using a Hazard Index (HI) previously established for work in areas contaminated with non-uranium nuclides. The radiological acceptance criteria for uranium are summarized in Table 1. Note that these limits are based on the assumption that radioactive daughter products have reached equilibrium.

  13. 46 CFR 28.275 - Acceptance criteria for instructors and course curricula.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Boundary Lines or With More Than 16 Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.275 Acceptance criteria for instructors and course curricula. (a) A Fishing... the contingencies listed in 46 CFR 28.270(a) including— (i) Experience as an instructor; or...

  14. 46 CFR 28.275 - Acceptance criteria for instructors and course curricula.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Boundary Lines or With More Than 16 Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.275 Acceptance criteria for instructors and course curricula. (a) A Fishing... the contingencies listed in 46 CFR 28.270(a) including— (i) Experience as an instructor; or...

  15. 46 CFR 28.275 - Acceptance criteria for instructors and course curricula.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Boundary Lines or With More Than 16 Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.275 Acceptance criteria for instructors and course curricula. (a) A Fishing... the contingencies listed in 46 CFR 28.270(a) including— (i) Experience as an instructor; or...

  16. 46 CFR 28.275 - Acceptance criteria for instructors and course curricula.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the Boundary Lines or With More Than 16 Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.275 Acceptance criteria for instructors and course curricula. (a) A Fishing... the contingencies listed in 46 CFR 28.270(a) including— (i) Experience as an instructor; or...

  17. 46 CFR 28.275 - Acceptance criteria for instructors and course curricula.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the Boundary Lines or With More Than 16 Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.275 Acceptance criteria for instructors and course curricula. (a) A Fishing... the contingencies listed in 46 CFR 28.270(a) including— (i) Experience as an instructor; or...

  18. Evidence for Broadening Criteria for Atypical Depression Which May Define a Reactive Depressive Disorder.

    PubMed

    Silverstein, Brett; Angst, Jules

    2015-01-01

    Objective. Arguing that additional symptoms should be added to the criteria for atypical depression. Method. Published research articles on atypical depression are reviewed. Results. (1) The original studies upon which the criteria for atypical depression were based cited fatigue, insomnia, pain, and loss of weight as characteristic symptoms. (2) Several studies of DSM depressive criteria found patients with atypical depression to exhibit high levels of insomnia, fatigue, and loss of appetite/weight. (3) Several studies have found atypical depression to be comorbid with headaches, bulimia, and body image issues. (4) Most probands who report atypical depression meet criteria for "somatic depression," defined as depression associated with several of disordered eating, poor body image, headaches, fatigue, and insomnia. The gender difference in prevalence of atypical depression results from its overlap with somatic depression. Somatic depression is associated with psychosocial measures related to gender, linking it with the descriptions of atypical depression as "reactive" appearing in the studies upon which the original criteria for atypical depression were based. Conclusion. Insomnia, disordered eating, poor body image, and aches/pains should be added as criteria for atypical depression matching criteria for somatic depression defining a reactive depressive disorder possibly distinct from endogenous melancholic depression. PMID:26258131

  19. Wall thinning acceptance criteria for degraded carbon steel piping systems using FAD methodology

    SciTech Connect

    Lam, P.S.; Gupta, N.K.

    1995-02-01

    As part of the structural integrity assessment for Savannah River Site (SRS) piping systems, an acceptance criteria methodology for minimum pipe wall thickness has been developed for carbon steel piping. If a measured pipe thickness during inspection cannot meet the 87.5% of the nominal wall thickness specified in the ASME Code Case N-480, the acceptance criteria must be invoked. For a particular pipe, the larger of the two minimum thickness values obtained from the code stress check and the CEGB-R6 Failure Assessment Diagram (FAD) methodology is the minimum wall thickness for the acceptance criteria. The code stress check is based on the ASME/ANSI B31.1 Code, ASME Code Case N-480, and the SRS reactor restart criteria. The pipe wall thickness is calculated from the code equations and the applied loads. In fracture analysis, three types of axial and circumferential flaws are assumed to exist in the pipes based on the weld defects found in service history. For each flaw configuration, the stress intensity factors and the limit load solutions are calculated. These quantities are input to FAD to solve for the corresponding wall thickness required for the pipe to sustain the postulated flaws and to meet ASME safety margins under the applied loads.

  20. TRU waste acceptance criteria for the Waste Isolation Pilot Plant: Revision 3

    SciTech Connect

    Not Available

    1989-01-01

    This document is intended to delineate the criteria by which unclassified waste will be accepted for emplacement at the Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico and describe the bases upon which these criteria were established. These criteria are not intended to be specifications but rather limits that will allow waste generating and shipping sites to develop their own procedures and specifications for preparation of TRU waste for shipment to the WIPP. These criteria will also allow waste generating sites to plan future facilities for waste preparation that will produce TRU waste forms compatible with WIPP waste emplacement and isolation requirements. These criteria only apply to contract-handled (CH) and remote-handled (RH) transuranic (TRU) waste forms and are not intended to apply to beta-gamma wastes, spent fuel, high-level waste (HLW), low-level waste (LLW), low specific activity (LSA) waste, or forms of radioactive waste for experimental purposes. Specifications for receipt of experimental waste forms will be prepared by the responsible projects in conjunction with the staff of the WIPP project at a later date. In addition, these criteria only apply to waste emplaced in bedded rock salt. Technical bases for these criteria may differ significantly from those for other host rocks. 25 refs. 4 figs., 1 tab.

  1. Defining Quality Criteria for Online Continuing Medical Education Modules Using Modified Nominal Group Technique

    ERIC Educational Resources Information Center

    Shortt, S. E. D.; Guillemette, Jean-Marc; Duncan, Anne Marie; Kirby, Frances

    2010-01-01

    Introduction: The rapid increase in the use of the Internet for continuing education by physicians suggests the need to define quality criteria for accredited online modules. Methods: Continuing medical education (CME) directors from Canadian medical schools and academic researchers participated in a consensus process, Modified Nominal Group…

  2. LANL Waste acceptance criteria, Chapter 3, radioactive liquid waste treatment facility

    SciTech Connect

    McClenahan, Robert L.

    2006-08-01

    The Radioactive Liquid Waste Treatment Facility (RLWTF) receives and treats aqueous radioactive wastewater generated at Los Alamos National Laboratory (LANL) to meet he discharge criteria specified in a National Pollution Discharge Elimination System (NPDES) permit. The majority of this wastewater is received at the RL WTF through a network of buried pipelines, known as the Radioactive Liquid Waste Collection System (RLWCS). Other wastewater is transported to the RL WTF by truck. The Waste Acceptance Criteria (WAC) outlined in this Chapter are applicable to all radioactive wastewaters which are conveyed to the Technical Area 50(T A-50), RL WTF by the RL WCS or by truck.

  3. HOW TO DEAL WITH WASTE ACCEPTANCE UNCERTAINTY USING THE WASTE ACCEPTANCE CRITERIA FORECASTING AND ANALYSIS CAPABILITY SYSTEM (WACFACS)

    SciTech Connect

    Redus, K. S.; Hampshire, G. J.; Patterson, J. E.; Perkins, A. B.

    2002-02-25

    The Waste Acceptance Criteria Forecasting and Analysis Capability System (WACFACS) is used to plan for, evaluate, and control the supply of approximately 1.8 million yd3 of low-level radioactive, TSCA, and RCRA hazardous wastes from over 60 environmental restoration projects between FY02 through FY10 to the Oak Ridge Environmental Management Waste Management Facility (EMWMF). WACFACS is a validated decision support tool that propagates uncertainties inherent in site-related contaminant characterization data, disposition volumes during EMWMF operations, and project schedules to quantitatively determine the confidence that risk-based performance standards are met. Trade-offs in schedule, volumes of waste lots, and allowable concentrations of contaminants are performed to optimize project waste disposition, regulatory compliance, and disposal cell management.

  4. Development of Waste Acceptance Criteria at 221-U Building: Initial Flow and Transport Scoping Calculations

    SciTech Connect

    Freedman, Vicky L.; Zhang, Z. F.; Keller, Jason M.; Chen, Yousu

    2007-05-30

    This report documents numerical flow and transport simulations performed that establish initial waste acceptance criteria for the potential waste streams that may be safely sequestered in the 221-U Building and similar canyon structures. Specifically, simulations were executed to identify the maximum loading of contaminant mass (without respect to volume) that can be emplaced within the 221-U Building with no more than 1 pCi/m2 of contaminant migrating outside the structure within a 1,000 year time period. The initial scoping simulations were executed in one dimension to assess important processes, and then two dimensions to establish waste acceptance criteria. Two monolithic conditions were assessed: (1) a grouted canyon monolith; and (2) a canyon monolith filled with sand, both assuming no cracks or fissures were present to cause preferential transport. A three-staged approach was taken to account for different processes that may impact the amount of contaminant that can be safely sequestered in canyon structure. In the first stage, flow and transport simulations established waste acceptance criteria based on a linear (Kd) isotherm approach. In the second stage, impacts on thermal loading were examined and the differences in waste acceptance criteria quantified. In the third stage of modeling, precipitation/dissolution reactions were considered on the release and transport of the contaminants, and the subsequent impact on the maximum contaminant loading. The reactive transport modeling is considered a demonstration of the reactive transport capability, and shows the importance of its use for future performance predictions once site-specific data have been obtained.

  5. PCR for Detection of Herpes Simplex Virus in Cerebrospinal Fluid: Alternative Acceptance Criteria for Diagnostic Workup

    PubMed Central

    Alonso, Roberto; de Egea, Viviana; Usubillaga, Rafael; Muñoz, Patricia; Bouza, Emilio

    2013-01-01

    The determination of herpes simplex virus (HSV) infection using a PCR assay is one of the most commonly requested tests for analysis of cerebrospinal fluid (CSF), although only a very low proportion of results are positive. A previously reported study showed that selecting only those CSF samples with >5 leukocytes/mm3 or a protein level of >50 mg/dl was adequate for the diagnostic workup. The aim of the present study was to assess the reliability of alternative acceptance criteria based on elevated CSF white blood cell counts (>10 cells/mm3). We analyzed all requests for HSV PCR received between January 2008 and December 2011. CSF samples were accepted for analysis if they had >10 cells/mm3 or if the sample was from an immunocompromised patient or a child aged <2 years. In order to evaluate our selection criteria, we identified those CSF samples with a leukocyte count of 5 to 10 cells/mm3 or protein levels of >50 mg/dl in order to test them for HSV type 1 and 2 (HSV-1 and HSV-2) DNA. During the study period, 466 CSF samples were submitted to the microbiology laboratory for HSV PCR. Of these, 268 (57.5%) were rejected, and 198 (42.5%) were tested according to our routine criteria. Of the tested samples, 11 (5.5%) were positive for HSV DNA (7 for HSV-1 and 4 for HSV-2). Of the 268 rejected specimens, 74 met the criteria of >5 cells/mm3 and/or protein levels of >50 mg/dl. Of these, 70 (94.6%) were available for analysis. None of the samples yielded a positive HSV PCR result. Acceptance criteria based on CSF leukocyte counts, host immune status, and age can help to streamline the application of HSV PCR without reducing sensitivity. PMID:23804382

  6. Variation transmission model for setting acceptance criteria in a multi-staged pharmaceutical manufacturing process.

    PubMed

    Montes, Richard O

    2012-03-01

    Pharmaceutical manufacturing processes consist of a series of stages (e.g., reaction, workup, isolation) to generate the active pharmaceutical ingredient (API). Outputs at intermediate stages (in-process control) and API need to be controlled within acceptance criteria to assure final drug product quality. In this paper, two methods based on tolerance interval to derive such acceptance criteria will be evaluated. The first method is serial worst case (SWC), an industry risk minimization strategy, wherein input materials and process parameters of a stage are fixed at their worst-case settings to calculate the maximum level expected from the stage. This maximum output then becomes input to the next stage wherein process parameters are again fixed at worst-case setting. The procedure is serially repeated throughout the process until the final stage. The calculated limits using SWC can be artificially high and may not reflect the actual process performance. The second method is the variation transmission (VT) using autoregressive model, wherein variation transmitted up to a stage is estimated by accounting for the recursive structure of the errors at each stage. Computer simulations at varying extent of variation transmission and process stage variability are performed. For the scenarios tested, VT method is demonstrated to better maintain the simulated confidence level and more precisely estimate the true proportion parameter than SWC. Real data examples are also presented that corroborate the findings from the simulation. Overall, VT is recommended for setting acceptance criteria in a multi-staged pharmaceutical manufacturing process.

  7. Preliminary waste acceptance criteria for the ICPP spent fuel and waste management technology development program

    SciTech Connect

    Taylor, L.L.; Shikashio, R.

    1993-09-01

    The purpose of this document is to identify requirements to be met by the Producer/Shipper of Spent Nuclear Fuel/High-LeveL Waste SNF/HLW in order for DOE to be able to accept the packaged materials. This includes defining both standard and nonstandard waste forms.

  8. Development of J-integral based UT flaw acceptance criteria for Savannah River reactor tanks

    SciTech Connect

    Mehta, H.S.; Ranganath, S.; Awadalla, N.G.; Sindelar, R.L.; Caskey, G.R. Jr.; Daugherty, W.L.

    1991-12-31

    The tank of a Savannah River Site reactor is a cylinder approximately 16 feet in diameter and 14 feet high and is not pressurized except for a 5 psig helium blanket gas in addition to the hydrostatic head of the heavy water (D{sub 2}O) moderator. The tank is made of Type 304 Stainless steel fabricated into cylindrical shells with 0.5 inch thick four to six wrought plates per vessel. The shell was made up in two flat half-sections for later rolling and welding. The tank bottom section containing the moderator effluent nozzles was welded to the shell in a T-Joint configuration. An ultrasonic (UT) in-service inspection program has been developed for the examination of these reactor tanks. Prior to the initiation of these inspections, criteria for the disposition of any indications that may be found were required. This paper describes the fracture mechanics evaluations that formed the technical bases for the flaw acceptance criteria. The fracture mechanics evaluation considered detailed finite element calculated stress states in the various regions of the tanks, measured irradiated fracture toughness properties (irradiated condition material J-R curves), fluence levels in the tanks, and intergranular stress corrosion cracking growth rates in the reactor environment. The irradiation program was conducted at the High Flux Isotope Reactor at Oak Ridge National Laboratory. Tensile and fracture toughness data were obtained from 36 compact tension, tensile and Charpy V-notch specimens. Through wall cracks are postulated in various regions of the tank and critical crack lengths are calculated by the elastic-plastic fracture mechanics based J-Integral/Tearing Modulus (J/T) approach. The applied values of J-integral were calculated by the well-known GE/EPRI estimation scheme. Acceptable crack lengths are then calculated following generally accepted safety factors based on the ASME Pressure Vessel Code. The acceptance criteria are then briefly described.

  9. Development of J-integral based UT flaw acceptance criteria for Savannah River reactor tanks

    SciTech Connect

    Mehta, H.S.; Ranganath, S. . Nuclear Energy Div.); Awadalla, N.G.; Sindelar, R.L.; Caskey, G.R. Jr.; Daugherty, W.L. )

    1991-01-01

    The tank of a Savannah River Site reactor is a cylinder approximately 16 feet in diameter and 14 feet high and is not pressurized except for a 5 psig helium blanket gas in addition to the hydrostatic head of the heavy water (D{sub 2}O) moderator. The tank is made of Type 304 Stainless steel fabricated into cylindrical shells with 0.5 inch thick four to six wrought plates per vessel. The shell was made up in two flat half-sections for later rolling and welding. The tank bottom section containing the moderator effluent nozzles was welded to the shell in a T-Joint configuration. An ultrasonic (UT) in-service inspection program has been developed for the examination of these reactor tanks. Prior to the initiation of these inspections, criteria for the disposition of any indications that may be found were required. This paper describes the fracture mechanics evaluations that formed the technical bases for the flaw acceptance criteria. The fracture mechanics evaluation considered detailed finite element calculated stress states in the various regions of the tanks, measured irradiated fracture toughness properties (irradiated condition material J-R curves), fluence levels in the tanks, and intergranular stress corrosion cracking growth rates in the reactor environment. The irradiation program was conducted at the High Flux Isotope Reactor at Oak Ridge National Laboratory. Tensile and fracture toughness data were obtained from 36 compact tension, tensile and Charpy V-notch specimens. Through wall cracks are postulated in various regions of the tank and critical crack lengths are calculated by the elastic-plastic fracture mechanics based J-Integral/Tearing Modulus (J/T) approach. The applied values of J-integral were calculated by the well-known GE/EPRI estimation scheme. Acceptable crack lengths are then calculated following generally accepted safety factors based on the ASME Pressure Vessel Code. The acceptance criteria are then briefly described.

  10. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast.

    PubMed

    Lee, Cheryl Q E; Gardner, Lucy; Turco, Margherita; Zhao, Nancy; Murray, Matthew J; Coleman, Nicholas; Rossant, Janet; Hemberger, Myriam; Moffett, Ashley

    2016-02-01

    Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage. We have selected criteria that are characteristic of primary first-trimester trophoblast: a set of protein markers, HLA class I profile, methylation of ELF5, and expression of microRNAs (miRNAs) from the chromosome 19 miRNA cluster (C19MC). We tested these criteria on cells previously reported to show some phenotypic characteristics of trophoblast: bone morphogenetic protein (BMP)-treated human ESC and 2102Ep, an embryonal carcinoma cell line. Both cell types only show some, but not all, of the four trophoblast criteria. Thus, BMP-treated human ESC have not fully differentiated to trophoblast. Our study identifies a robust panel, including both protein and non-protein-coding markers that, in combination, can be used to reliably define cells as characteristic of early trophoblast. PMID:26862703

  11. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

    PubMed Central

    Lee, Cheryl Q.E.; Gardner, Lucy; Turco, Margherita; Zhao, Nancy; Murray, Matthew J.; Coleman, Nicholas; Rossant, Janet; Hemberger, Myriam; Moffett, Ashley

    2016-01-01

    Summary Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage. We have selected criteria that are characteristic of primary first-trimester trophoblast: a set of protein markers, HLA class I profile, methylation of ELF5, and expression of microRNAs (miRNAs) from the chromosome 19 miRNA cluster (C19MC). We tested these criteria on cells previously reported to show some phenotypic characteristics of trophoblast: bone morphogenetic protein (BMP)-treated human ESC and 2102Ep, an embryonal carcinoma cell line. Both cell types only show some, but not all, of the four trophoblast criteria. Thus, BMP-treated human ESC have not fully differentiated to trophoblast. Our study identifies a robust panel, including both protein and non-protein-coding markers that, in combination, can be used to reliably define cells as characteristic of early trophoblast. PMID:26862703

  12. ENVIROCARE OF UTAH: EXPANDING WASTE ACCEPTANCE CRITERIA TO PROVIDE LOW-LEVEL AND MIXED WASTE DISPOSAL OPTIONS

    SciTech Connect

    Rogers, B.; Loveland, K.

    2003-02-27

    Envirocare of Utah operates a low-level radioactive waste disposal facility 80 miles west of Salt Lake City in Clive, Utah. Accepted waste types includes NORM, 11e2 byproduct material, Class A low-level waste, and mixed waste. Since 1988, Envirocare has offered disposal options for environmental restoration waste for both government and commercial remediation projects. Annual waste receipts exceed 12 million cubic feet. The waste acceptance criteria (WAC) for the Envirocare facility have significantly expanded to accommodate the changing needs of restoration projects and waste generators since its inception, including acceptable physical waste forms, radiological acceptance criteria, RCRA requirements and treatment capabilities, PCB acceptance, and liquids acceptance. Additionally, there are many packaging, transportation, and waste management options for waste streams acceptable at Envirocare. Many subcontracting vehicles are also available to waste generators for both government and commercial activities.

  13. Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics.

    PubMed

    Rau, Tilman T; Agaimy, Abbas; Gehoff, Anastasia; Geppert, Carol; Jung, Klaus; Knobloch, Katharina; Langner, Cord; Lugli, Alessandro; Groenbus-Lurkin, Irene; Nagtegaal, Iris D; Rüschoff, Josef; Saegert, Xavier; Sarbia, Mario; Schneider-Stock, Regine; Vieth, Michael; Zwarthoff, Ellen C; Hartmann, Arndt

    2014-06-01

    Criteria for the diagnosis of serrated colorectal lesions (hyperplastic polyp, sessile serrated adenoma without or with dysplasia--which we called mixed polyp--and traditional serrated adenoma) for which consensus has been reached should be validated for applicability in daily practice in terms of inter-observer reproducibility and their association with clinical features and (epi)genetic events. A study set was created from a consecutive series of colorectal polyps (n = 1,926) by selecting all sessile serrated adenomas, traditional serrated adenomas and mixed polyps. We added consecutive series of hyperplastic polyps, classical adenomas and normal mucosa samples for a total of 200 specimens. With this series, we conducted an inter-observer study, encompassing ten pathologists with gastrointestinal pathology experience from five European countries, in three rounds in which all cases were microscopically evaluated. An assessment of single morphological criteria was included, and these were correlated with clinical parameters and the mutation status of KRAS, BRAF and PIK3CA and the methylation status of MLH1. Gender, age and localisation were significantly associated with certain types of lesions. Kappa statistics revealed moderate to good inter-observer agreement for polyp classification (κ = 0.56 to 0.63), but for single criteria, this varied considerably (κ = 0.06 to 0.82). BRAF mutations were frequently found in hyperplastic polyps (86 %, 62/72) and sessile serrated adenomas (80 %, 41/51). KRAS mutations occurred more frequently in traditional serrated adenomas (78 %, 7/9) and less so in classical adenomas (20 %, 10/51). Single morphological criteria for sessile serrated adenomas showed significant correlation with BRAF mutation (all p ≤ 0.001), and those for classical adenomas or traditional serrated adenoma correlated significantly with KRAS mutation (all p < 0.001). Therefore, single well-defined morphological criteria are predictive for

  14. Elastic-Plastic Strain Acceptance Criteria for Structures Subject to Rapidly Applied Transient Dynamic Loading

    SciTech Connect

    W.R. Solonick

    2003-04-01

    Rapidly applied transient dynamic loads produce stresses and deflections in structures that typically exceed those from static loading conditions. Previous acceptance criteria for structures designed for rapidly applied transient dynamic loading limited stresses to those determined from elastic analysis. Different stress limits were established for different grades of structure depending upon the amount of permanent set considered acceptable. Structure allowed to sustain very limited permanent set is designed to stress limits not significantly greater than yield stress. Greater permanent set in structure under rapidly applied transient dynamic loading conditions is permitted by establishing stress limits that are significantly greater than yield stress but still provide adequate safety margin (with respect to failure). This paper presents a strain-based elastic-plastic (i.e., inelastic) analysis criterion developed as an alternative to the more conservative stress-based elastic analysis stress criterion for structures subjected to rapidly applied transient dynamic loading. The strain limits established are based on material ductility considerations only and are set as a fraction of the strain at ultimate stress obtained from an engineering stress/strain curve of the material. Strains limits are categorized by type as membrane or surface and by region as general, local , or concentrated. The application of the elastic-plastic criterion provides a more accurate, less conservative design/analysis basis for structures than that used in elastic stress-based analysis criteria, while still providing adequate safety margins.

  15. Initial Acceptance Criteria Concepts and Data for Assessing Longevity of Low-Voltage Cable Insulations and Jackets

    SciTech Connect

    Gary toman

    2005-03-30

    This report establishes a basis for acceptance criteria, provides a method for estimating remaining low-voltage cable life, and provides aging profiles under various thermal and radiation conditions for available cable polymer condition-monitoring techniques. This report is not meant to be the final comprehensive source of acceptance criteria, but rather is intended for trial usage so that it can be further refined for easier reference in the future.

  16. 21 CFR 212.70 - What controls and acceptance criteria must I have for my finished PET drug products?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for my finished PET drug products? 212.70 Section 212.70 Food and Drugs FOOD AND DRUG ADMINISTRATION... acceptance criteria must I have for my finished PET drug products? (a) Specifications. You must establish specifications for each PET drug product, including criteria for determining identity, strength, quality,...

  17. 21 CFR 212.70 - What controls and acceptance criteria must I have for my finished PET drug products?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... for my finished PET drug products? 212.70 Section 212.70 Food and Drugs FOOD AND DRUG ADMINISTRATION... What controls and acceptance criteria must I have for my finished PET drug products? (a) Specifications. You must establish specifications for each PET drug product, including criteria for...

  18. Contact-Handled Transuranic Waste Acceptance Criteria for the Waste Isolation Pilot Plant

    SciTech Connect

    Washington TRU Solutions LLC

    2005-12-29

    The purpose of this document is to summarize the waste acceptance criteria applicable to the transportation, storage, and disposal of contact-handled transuranic (CH-TRU) waste at the Waste Isolation Pilot Plant (WIPP). These criteria serve as the U.S. Department of Energy's (DOE) primary directive for ensuring that CH-TRU waste is managed and disposed of in a manner that protects human health and safety and the environment.The authorization basis of WIPP for the disposal of CH-TRU waste includes the U.S.Department of Energy National Security and Military Applications of Nuclear EnergyAuthorization Act of 1980 (reference 1) and the WIPP Land Withdrawal Act (LWA;reference 2). Included in this document are the requirements and associated criteriaimposed by these acts and the Resource Conservation and Recovery Act (RCRA,reference 3), as amended, on the CH-TRU waste destined for disposal at WIPP.|The DOE TRU waste sites must certify CH-TRU waste payload containers to thecontact-handled waste acceptance criteria (CH-WAC) identified in this document. Asshown in figure 1.0, the flow-down of applicable requirements to the CH-WAC istraceable to several higher-tier documents, including the WIPP operational safetyrequirements derived from the WIPP CH Documented Safety Analysis (CH-DSA;reference 4), the transportation requirements for CH-TRU wastes derived from theTransuranic Package Transporter-Model II (TRUPACT-II) and HalfPACT Certificates ofCompliance (references 5 and 5a), the WIPP LWA (reference 2), the WIPP HazardousWaste Facility Permit (reference 6), and the U.S. Environmental Protection Agency(EPA) Compliance Certification Decision and approval for PCB disposal (references 7,34, 35, 36, and 37). The solid arrows shown in figure 1.0 represent the flow-down of allapplicable payload container-based requirements. The two dotted arrows shown infigure 1.0 represent the flow-down of summary level requirements only; i.e., the sitesmust reference the regulatory source

  19. Proposed GTA welding specification and acceptance criteria for the MC4163

    SciTech Connect

    Kwiatkowski, J.J.

    1991-04-12

    This specification documents the gas tungsten arc (GTA) welding process and production weld acceptance criteria requirements for the MC4163. This document is written specifically to apply to the welds on the MC4163 and is not to be used as a general gas tungsten arc welding specification. All sections of this specification must be complied with unless specifically exempted in writing. There are a total of five welds with three different joint designs required to fabricate the MC4163. In the order of fabrication they are (1) initiator closure disc, (2) nozzle to case girth welds, two and, (3) nozzle closure disc welds, two. This specification will only address the nozzle to case girth welds and the nozzle closure disc welds.

  20. CHARACTERIZATION OF TANK 50 SLURRY FOR SALTSTONE WASTE ACCEPTANCE CRITERIA, APRIL 2007 SAMPLES

    SciTech Connect

    Zeigler, K; Ned Bibler, N; David Diprete, D

    2007-12-07

    This report summarizes the results from the characterization of the second quarter April 2007 sampling of Tank 50H for the Saltstone Waste Acceptance Criteria (WAC). Six one liter samples were taken in polyethylene bottles to analyze for the WAC contaminants and a 200 mL sample was taken in a steel container for analysis of volatile organic compounds. The information from this characterization will be given to Waste Solidification Engineering personnel to qualify the transfer of aqueous waste to the Saltstone Facility. The following conclusions are drawn from the analytical results found in this report: (1) All six of the one liter samples taken in April 2007 from the mixed slurry in Tank 50 have the same compositions within the experimental uncertainty of the analyses. (2) Of the ninety-one process, chemical, and radioactive WAC target or limit contaminants listed in Revision 7 of the 'Waste Acceptance Criteria for Aqueous Waste sent to the Z-Area Saltstone Production Facility', eighty-nine had concentrations that were unequivocally less than the WAC limit or target. (3) The two contaminants whose concentrations could not be shown to be less than their WAC targets were methanol and radioactive Nb-93m. Currently the AD Section of SRNL does not have a method for measuring methanol in caustic solutions. For Nb-93m the results are ambiguous due to possible interferences in the ICP-MS analysis from Zr-93 or Mo-93. (4) Of the six additional chemical and radioactive contaminants requested in the TTR for Saltstone qualification, five were measured or calculated. These were Sb, Be, Tl, along with total beta and gamma. The AD Section does not have a method to measure the 6th contaminant which was the cyanide ion.

  1. Heat exchanger staybolt acceptance criteria. Task number: 90-058-1

    SciTech Connect

    Lam, P.S.; Sindelar, R.L.; Barnes, D.M.

    1992-02-01

    The structural integrity demonstration of the primary coolant piping system includes evaluating the structural capacity of each component against a large break or equivalent Double-Ended Guillotine Break. A large break at the inlet or outlet heads of the heat exchangers would occur if the restraint members of the heads become inactive. The structural integrity of the heads is demonstrated by showing the redundant capacity of the staybolts to restrain the head at design conditions and under seismic loadings. The Savannah River Site heat exchanger head is attached to the tubesheet by 84 staybolts. Access to the staybolts is limited due to a welded seal cap over the staybolts. An ultrasonic testing (UT) inspection technique to provide an in-situ examination of the staybolts has recently been developed at SRS. Examination of the staybolts will be performed to ensure their service condition and configuration is within acceptance limits. An acceptance criteria methodology has been developed to disposition flaws reported in the staybolt inspections while ensuring adequate restraint capacity of the staybolts to maintain integrity of the heat exchanger heads against collapse. The methodology includes an approach for the baseline and periodic inspections of the staybolts. The heat exchanger head is analyzed with a three-dimensional finite element model. The restraint provided by the staybolts is evaluated for several postulated cases of inactive or missing staybolts. Evaluation of specific, inactive staybolt configurations based on the UT results can be performed with the finite element model and fracture methodology in this report.

  2. Defining and Assessing Analytical Performance Criteria for Transmissible Spongiform Encephalopathy-Detecting Amyloid Seeding Assays.

    PubMed

    Gray, John G; Graham, Catherine; Dudas, Sandor; Paxman, Eric; Vuong, Ben; Czub, Stefanie

    2016-05-01

    Transmissible spongiform encephalopathies (TSEs) are infectious, fatal neurodegenerative diseases that affect production animal health, and thus human food safety. Enhanced TSE detection methods mimic the conjectured basis for prion replication, in vitro; biological matrices can be tested for prion activity via their ability to convert recombinant cellular prion protein (PrP) into amyloid fibrils; fluorescent spectra changes of amyloid-binding fluorophores in the reaction vessel detect fibril formation. In vitro PrP conversion techniques have high analytical sensitivity for prions, comparable with that of bioassays, yet no such protocol has gained regulatory approval for use in animal TSE surveillance programs. This study describes a timed in vitro PrP conversion protocol with accurate, well-defined analytical criteria based on probability density and mass functions of TSE(+) and TSE(-) associated thioflavin T signal times, a new approach within this field. The prion detection model used is elk chronic wasting disease (CWD) in brain tissues. The protocol and analytical criteria proved as sensitive for elk CWD as two bioassay models, and upward of approximately 1.2 log10 more sensitive than the most sensitive TSE rapid test we assessed. Furthermore, we substantiate that timing in vitro PrP conversion may be used to titrate TSE infectivity, and, as a result, provide a comprehensive extrapolation of analytical sensitivity differences between bioassay, TSE rapid tests, and in vitro PrP conversion for elk CWD.

  3. Defining and Assessing Analytical Performance Criteria for Transmissible Spongiform Encephalopathy-Detecting Amyloid Seeding Assays.

    PubMed

    Gray, John G; Graham, Catherine; Dudas, Sandor; Paxman, Eric; Vuong, Ben; Czub, Stefanie

    2016-05-01

    Transmissible spongiform encephalopathies (TSEs) are infectious, fatal neurodegenerative diseases that affect production animal health, and thus human food safety. Enhanced TSE detection methods mimic the conjectured basis for prion replication, in vitro; biological matrices can be tested for prion activity via their ability to convert recombinant cellular prion protein (PrP) into amyloid fibrils; fluorescent spectra changes of amyloid-binding fluorophores in the reaction vessel detect fibril formation. In vitro PrP conversion techniques have high analytical sensitivity for prions, comparable with that of bioassays, yet no such protocol has gained regulatory approval for use in animal TSE surveillance programs. This study describes a timed in vitro PrP conversion protocol with accurate, well-defined analytical criteria based on probability density and mass functions of TSE(+) and TSE(-) associated thioflavin T signal times, a new approach within this field. The prion detection model used is elk chronic wasting disease (CWD) in brain tissues. The protocol and analytical criteria proved as sensitive for elk CWD as two bioassay models, and upward of approximately 1.2 log10 more sensitive than the most sensitive TSE rapid test we assessed. Furthermore, we substantiate that timing in vitro PrP conversion may be used to titrate TSE infectivity, and, as a result, provide a comprehensive extrapolation of analytical sensitivity differences between bioassay, TSE rapid tests, and in vitro PrP conversion for elk CWD. PMID:27068712

  4. Evaluation of ISDP Batch 2 Qualification Compliance to 512-S, DWPF, Tank Farm, and Saltstone Waste Acceptance Criteria

    SciTech Connect

    Shafer, A.

    2010-05-05

    The purpose of this report is to document the acceptability of the second macrobatch (Salt Batch 2) of Tank 49H waste to H Tank Farm, DWPF, and Saltstone for operation of the Interim Salt Disposition Project (ISDP). Tank 49 feed meets the Waste Acceptance Criteria (WAC) requirements specified by References 11, 12, and 13. Salt Batch 2 material is qualified and ready to be processed through ARP/MCU to the final disposal facilities.

  5. Characterization of Tank 23H Supernate Per Saltstone Waste Acceptance Criteria Analysis Requirements -2005

    SciTech Connect

    Oji, L

    2005-05-05

    Variable depth Tank 23H samples (22-inch sample [HTF-014] and 185-inch sample [HTF-013]) were pulled from Tank 23H in February, 2005 for characterization. The characterization of the Tank 23H low activity waste is part of the overall liquid waste processing activities. This characterization examined the species identified in the Saltstone Waste Acceptance Criteria (WAC) for the transfer of waste into the Salt-Feed Tank (SFT). The samples were delivered to the Savannah River National Laboratory (SRNL) and analyzed. Apart from radium-226 with an average measured detection limit of < 2.64E+03 pCi/mL, which is about the same order of magnitude as the WAC limit (< 8.73E+03 pCi/mL), none of the species analyzed was found to approach the limits provided in the Saltstone WAC. The concentration of most of the species analyzed for the Tank 23H samples were 2-5 orders of magnitude lower than the WAC limits. The achievable detection limits for a number of the analytes were several orders of magnitude lower than the WAC limits, but one or two orders of magnitude higher than the requested detection limits. Analytes which fell into this category included plutonium-241, europium-154/155, antimony-125, tin-126, ruthenium/rhodium-106, selenium-79, nickel-59/63, ammonium ion, copper, total nickel, manganese and total organic carbon.

  6. Characterization of Tank 23H Supernate Per Saltstone Waste Acceptance Criteria Analysis Requirements-2005

    SciTech Connect

    Oji, L

    2005-06-01

    Variable depth Tank 23H samples (22-inch sample [HTF-014] and 185-inch sample [HTF-013]) were pulled from Tank 23H in February, 2005 for characterization. The characterization of the Tank 23H low activity waste is part of the overall liquid waste processing activities. This characterization examined the species identified in the Saltstone Waste Acceptance Criteria (WAC) for the transfer of waste into the Salt-Feed Tank (SFT). The samples were delivered to the Savannah River National Laboratory (SRNL) and analyzed. Apart from radium-226 with an average measured detection limit of < 2.64E+03 pCi/mL, which is about the same order of magnitude as the WAC limit (< 8.73E+03 pCi/mL), none of the species analyzed was found to approach the limits provided in the Saltstone WAC. The concentration of most of the species analyzed for the Tank 23H samples were 2-5 orders of magnitude lower than the WAC limits. The achievable detection limits for a number of the analytes were several orders of magnitude lower than the WAC limits, but one or two orders of magnitude higher than the requested detection limits. Analytes which fell into this category included plutonium-241, europium-154/155, antimony-125, tin-126, ruthenium/rhodium-106, selenium-79, nickel-59/63, ammonium ion, copper, total nickel, manganese and total organic carbon.

  7. Development of flaw acceptance criteria for aging management of spent nuclear fuel multiple-purpose canisters

    SciTech Connect

    Lam, P.; Sindelar, R.

    2015-03-09

    A typical multipurpose canister (MPC) is made of austenitic stainless steel and is loaded with spent nuclear fuel assemblies. The canister may be subject to service-induced degradation when it is exposed to aggressive atmospheric environments during a possibly long-term storage period if the permanent repository is yet to be identified and readied. Because heat treatment for stress relief is not required for the construction of an MPC, stress corrosion cracking may be initiated on the canister surface in the welds or in the heat affected zone. An acceptance criteria methodology is being developed for flaw disposition should the crack-like defects be detected by periodic In-service Inspection. The first-order instability flaw sizes has been determined with bounding flaw configurations, that is, through-wall axial or circumferential cracks, and part-through-wall long axial flaw or 360° circumferential crack. The procedure recommended by the American Petroleum Institute (API) 579 Fitness-for-Service code (Second Edition) is used to estimate the instability crack length or depth by implementing the failure assessment diagram (FAD) methodology. The welding residual stresses are mostly unknown and are therefore estimated with the API 579 procedure. It is demonstrated in this paper that the residual stress has significant impact on the instability length or depth of the crack. The findings will limit the applicability of the flaw tolerance obtained from limit load approach where residual stress is ignored and only ligament yielding is considered.

  8. Development of flaw acceptance criteria for aging management of spent nuclear fuel multi-purpose canisters

    SciTech Connect

    Lam, Poh -Sang; Sindelar, Robert L.

    2015-03-09

    A typical multipurpose canister (MPC) is made of austenitic stainless steel and is loaded with spent nuclear fuel assemblies. The canister may be subject to service-induced degradation when it is exposed to aggressive atmospheric environments during a possibly long-term storage period if the permanent repository is yet to be identified and readied. Because heat treatment for stress relief is not required for the construction of an MPC, stress corrosion cracking may be initiated on the canister surface in the welds or in the heat affected zone. An acceptance criteria methodology is being developed for flaw disposition should the crack-like defects be detected by periodic in-service Inspection. The first-order instability flaw sizes has been determined with bounding flaw configurations, that is, through-wall axial or circumferential cracks, and part-through-wall long axial flaw or 360° circumferential crack. The procedure recommended by the American Petroleum Institute (API) 579 Fitness-for-Service code (Second Edition) is used to estimate the instability crack length or depth by implementing the failure assessment diagram (FAD) methodology. The welding residual stresses are mostly unknown and are therefore estimated with the API 579 procedure. It is demonstrated in this paper that the residual stress has significant impact on the instability length or depth of the crack. The findings will limit the applicability of the flaw tolerance obtained from limit load approach where residual stress is ignored and only ligament yielding is considered.

  9. Relationship between colorimetric (instrumental) evaluation and consumer-defined beef colour acceptability.

    PubMed

    Holman, Benjamin W B; Mao, Yanwei; Coombs, Cassius E O; van de Ven, Remy J; Hopkins, David L

    2016-11-01

    The relationship between instrumental colorimetric values (L*, a*, b*, the ratio of reflectance at 630nm and 580nm) and consumer perception of acceptable beef colour was evaluated using a web-based survey and standardised photographs of beef m. longissimus lumborum with known colorimetrics. Only L* and b* were found to relate to average consumer opinions of beef colour acceptability. Respondent nationality was also identified as a source of variation in beef colour acceptability score. Although this is a preliminary study with the findings necessitating additional investigation, these results suggest L* and b* as candidates for developing instrumental thresholds for consumer beef colour expectations.

  10. Relationship between colorimetric (instrumental) evaluation and consumer-defined beef colour acceptability.

    PubMed

    Holman, Benjamin W B; Mao, Yanwei; Coombs, Cassius E O; van de Ven, Remy J; Hopkins, David L

    2016-11-01

    The relationship between instrumental colorimetric values (L*, a*, b*, the ratio of reflectance at 630nm and 580nm) and consumer perception of acceptable beef colour was evaluated using a web-based survey and standardised photographs of beef m. longissimus lumborum with known colorimetrics. Only L* and b* were found to relate to average consumer opinions of beef colour acceptability. Respondent nationality was also identified as a source of variation in beef colour acceptability score. Although this is a preliminary study with the findings necessitating additional investigation, these results suggest L* and b* as candidates for developing instrumental thresholds for consumer beef colour expectations. PMID:27294520

  11. 'Optimal thermal range' in ectotherms: Defining criteria for tests of the temperature-size-rule.

    PubMed

    Walczyńska, Aleksandra; Kiełbasa, Anna; Sobczyk, Mateusz

    2016-08-01

    Thermal performance curves for population growth rate r (a measure of fitness) were estimated over a wide range of temperature for three species: Coleps hirtus (Protista), Lecane inermis (Rotifera) and Aeolosoma hemprichi (Oligochaeta). We measured individual body size and examined if predictions for the temperature-size rule (TSR) were valid for different temperatures. All three organisms investigated follow the TSR, but only over a specific range between minimal and optimal temperatures, while maintenance at temperatures beyond this range showed the opposite pattern in these taxa. We consider minimal and optimal temperatures to be species-specific, and moreover delineate a physiological range outside of which an ectotherm is constrained against displaying size plasticity in response to temperature. This thermal range concept has important implications for general size-temperature studies. Furthermore, the concept of 'operating thermal conditions' may provide a new approach to (i) defining criteria required for investigating and interpreting temperature effects, and (ii) providing a novel interpretation for many cases in which species do not conform to the TSR. PMID:27503715

  12. 32 CFR 37.530 - What criteria do I use in deciding whether to accept a recipient's cost sharing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-Award Business Evaluation Cost Sharing § 37.530 What criteria do I use in deciding whether to accept a... commitment to the success of the research project. Cash contributions clearly demonstrate commitment and they... accomplishment of the research project's objectives. (c) They are costs that may be charged to the project...

  13. 32 CFR 37.530 - What criteria do I use in deciding whether to accept a recipient's cost sharing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-Award Business Evaluation Cost Sharing § 37.530 What criteria do I use in deciding whether to accept a... commitment to the success of the research project. Cash contributions clearly demonstrate commitment and they... accomplishment of the research project's objectives. (c) They are costs that may be charged to the project...

  14. 32 CFR 37.530 - What criteria do I use in deciding whether to accept a recipient's cost sharing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and development (IR&D) costs, as described at 32 CFR 34.13(a)(5)(ii), that meet all of the criteria in paragraphs (a) through (e) of this section. IR&D is acceptable as cost sharing, even though it may be... principles at 48 CFR part 31 allow a for-profit firm that has expenditure-based, Federal...

  15. 32 CFR 37.530 - What criteria do I use in deciding whether to accept a recipient's cost sharing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and development (IR&D) costs, as described at 32 CFR 34.13(a)(5)(ii), that meet all of the criteria in paragraphs (a) through (e) of this section. IR&D is acceptable as cost sharing, even though it may be... principles at 48 CFR part 31 allow a for-profit firm that has expenditure-based, Federal...

  16. 32 CFR 37.530 - What criteria do I use in deciding whether to accept a recipient's cost sharing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and development (IR&D) costs, as described at 32 CFR 34.13(a)(5)(ii), that meet all of the criteria in paragraphs (a) through (e) of this section. IR&D is acceptable as cost sharing, even though it may be... principles at 48 CFR part 31 allow a for-profit firm that has expenditure-based, Federal...

  17. 10 CFR 50.46 - Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... light-water nuclear power reactors. 50.46 Section 50.46 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... Approvals § 50.46 Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors. (a)(1)(i) Each boiling or pressurized light-water nuclear power reactor fueled with uranium...

  18. 10 CFR 50.46 - Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... light-water nuclear power reactors. 50.46 Section 50.46 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... Approvals § 50.46 Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors. (a)(1)(i) Each boiling or pressurized light-water nuclear power reactor fueled with uranium...

  19. 10 CFR 50.46 - Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... light-water nuclear power reactors. 50.46 Section 50.46 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... Approvals § 50.46 Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors. (a)(1)(i) Each boiling or pressurized light-water nuclear power reactor fueled with uranium...

  20. 10 CFR 50.46 - Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... light-water nuclear power reactors. 50.46 Section 50.46 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... Approvals § 50.46 Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors. (a)(1)(i) Each boiling or pressurized light-water nuclear power reactor fueled with uranium...

  1. 10 CFR 50.46 - Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... light-water nuclear power reactors. 50.46 Section 50.46 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC... Approvals § 50.46 Acceptance criteria for emergency core cooling systems for light-water nuclear power reactors. (a)(1)(i) Each boiling or pressurized light-water nuclear power reactor fueled with uranium...

  2. Evaluation of Sludge Batch 5 Qualification with ISDP Salt Batch 1 Compliance to DWPF Waste Acceptance Criteria

    SciTech Connect

    Shafer, A.

    2010-05-05

    The purpose of this report is to document the acceptability of Sludge Batch 5 with the initial macrobatch operation of the Interim Salt Disposition Project (ISDP) waste to the Defense Waste Processing Facility (DWPF). This report was prepared to comply with the requirements listed in the Waste Acceptance Criteria for Sludge, Actinide Removal Process (ARP), and Modular Caustic Side Solvent Extraction Unit (MCU) Process Transfers to 512-S and DWPF. The requirements for transfers to 512-S were evaluated during ISDP Salt Batch 1 qualification. The calculations of sludge concentrations are based entirely on the Tank 51 sample processed at SRNL. This is conservative because Tank 51 is blended with the dilute feed in the DWPF Feed Tank (Tank 40). This report documents the acceptability of sludge only as well as Sludge Batch 5 sludge slurry combined with ARP/MCU products for feed to DWPF. All criteria were met for unblended Tank 51 material.

  3. Defining the drivers for accepting decision making automation in air traffic management.

    PubMed

    Bekier, Marek; Molesworth, Brett R C; Williamson, Ann

    2011-04-01

    Air Traffic Management (ATM) operators are under increasing pressure to improve the efficiency of their operation to cater for forecasted increases in air traffic movements. One solution involves increasing the utilisation of automation within the ATM system. The success of this approach is contingent on Air Traffic Control Operators' (ATCOs) willingness to accept increased levels of automation. The main aim of the present research was to examine the drivers underpinning ATCOs' willingness to accept increased utilisation of automation within their role. Two fictitious scenarios involving the application of two new automated decision-making tools were created. The results of an online survey revealed traditional predictors of automation acceptance such as age, trust and job satisfaction explain between 4 and 7% of the variance. Furthermore, these predictors varied depending on the purpose in which the automation was to be employed. These results are discussed from an applied and theoretical perspective. STATEMENT OF RELEVANCE: Efficiency improvements in ATM are required to cater for forecasted increases in air traffic movements. One solution is to increase the utilisation of automation within Air Traffic Control. The present research examines the drivers underpinning air traffic controllers' willingness to accept increased levels of automation in their role.

  4. An alternative regionalization scheme for defining nutrient criteria for rivers and streams

    USGS Publications Warehouse

    Robertson, Dale M.; Saad, David A.; Wieben, Ann M.

    2001-01-01

    The environmental nutrient zone approach can be applied to specific states or nutrient ecoregions and used to develop criteria as a function of stream type. This approach can also be applied on the basis of environmental characteristics of the watershed alone rather than the general environmental characteristics from the region in which the site is located. The environmental nutrient zone approach will enable states to refine the basic nutrient criteria established by the USEPA by developing attainable criteria given the environmental characteristics where the streams are located.

  5. The U.S. Nuclear Regulatory Commission's Strategy for Revising the RIA Acceptance Criteria

    SciTech Connect

    Clifford, Paul M.

    2007-07-01

    The U.S. Nuclear Regulatory Commission (NRC) has issued interim criteria and guidance for the reactivity-initiated accident (RIA) within the latest revision to NUREG-0800, 'Standard Review Plan' (SRP), Section 4.2, 'Fuel System Design', Appendix B (Revision 03, March 2007). The purpose of this paper is as follows: 1. present a change in regulatory staff position regarding the requirements of 10 CFR 50, Appendix A, General Design Criteria 28 (GDC28) and changes in regulatory guidance provided in Regulatory Guide (RG) 1.77, RG 1.195, RG 1.183, and previous versions of NUREG-0800 SRP; 2. describe the implementation strategy and schedule for both new reactors and the existing fleet; and 3. encourage licensees and nuclear fuel vendors to (1) develop improved core physics analytical methods to allow a more deliberate transition to the new fuel cladding failure criteria and (2) develop the technical basis to address the new core coolability criteria. (authors)

  6. Criteria Used to Define and Evaluate Socially Competent Behavior among Women.

    ERIC Educational Resources Information Center

    Gambrill, Eileen D.; Richey, Cheryl A.

    1986-01-01

    Describes and critiques criteria used to evaluate socially competent behavior of women. Discusses the relationship between the definition of competence used and the assessment methods relied on. Notes the advantages of focusing on specific goals and provides a checklist that consumers can use to review the content of training programs. (Author/ABB)

  7. Fatigue acceptance test limit criteria for larger diameter rolled thread fasteners

    SciTech Connect

    Kephart, A.R.

    1999-05-19

    This document describes a fatigue lifetime acceptance test criterion by which studs having rolled threads, larger than 1.0 inches (25 mm) in diameter, can be assured to meet minimum quality attributes associated with a controlled rolling process.

  8. Expanding the criteria for defining success when evaluating weight loss intervention programs.

    PubMed

    Sargent, R G; DiGioacchino, R F; Miller, P M; Sharpe, P A; Hussey, J R

    2000-12-01

    In order to evaluate outcomes among former participants in a residential weight loss program, attendees were surveyed from 1 to 5 years post-intervention. A total of 187 respondents were studied for weight changes and behavioral practices. Diet practices were assessed by number of servings per day using the Food Guide Pyramid recommendations as a guideline for indicating fruit and vegetable intake. Exercise behaviors were measured in frequency, duration, and intensity, and a weighted score was computed to obtain units for describing physical activity. Maintaining a 10% weight loss from the program entry weight, consuming five or more servings per day of fruits and/or vegetables (5-a-day) and maintaining an "active" level of physical activity were included in criteria for describing intervention success. Those meeting two of the three criteria were categorized as "successful," which included 35.8% of the study population. Because each of these behaviors (5-a-day, active lifestyle, and modest weight loss maintenance) result in independent risk reduction, it is recommended that future weight loss intervention evaluations expand the criteria for describing successful impacts and outcomes to include not only weight maintenance, but also physical activity and diet compliance behaviors. PMID:15001056

  9. 76 FR 27925 - Requirements for Maintenance of Inspections, Tests, Analyses, and Acceptance Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    .... Earl Libby, Office of New Reactors, U.S. Nuclear Regulatory Commission, Washington DC 20555-0001...) part 52, ``Licenses, Certifications, and Approvals for Nuclear Power Plants,'' on April 18, 1989 (54 FR..., ``Quality Assurance Criteria for Nuclear Power Plants and Fuel Reprocessing Plants,'' to prepare and...

  10. How strict should specimen acceptance or rejection criteria be for diagnostic semen analysis? An opinion.

    PubMed

    Woodward, Bryan J; Tomlinson, Mathew J

    2015-06-01

    Medical laboratory accreditation (previously by Clinical Pathology Accreditation UK Ltd and now by the United Kingdom Accreditation Service) has been integral to improving standards and service quality in the UK. With the recent introduction of the ISO15189 standard, all laboratories offering a clinical diagnostic service are required to demonstrate further improvement, with more emphasis on validation and assessment of the uncertainty levels associated with testing. This applies not only to 'bench testing', but also to the evidence-base for all pre-analytical and post-analytical procedures. To reduce the risk of external influences on andrology test results, semen sample rejection criteria were developed, including confirmation of patient identity, a strict time limit from sample production to testing, the use of toxicity-tested containers, a prescribed sexual abstinence and a need for complete sample collection. However, such criteria were originally developed by the World Health Organization in order to standardise analysis rather than reject testing outright, and should therefore be implemented with caution. Rejecting samples with normal semen parameters because they fail to meet some of the criteria as outlined above would be a waste of resources and adversely affect user (the person who requested or provided the sample) satisfaction. This document evaluates the evidence base underlying commonly used criteria for specimen rejection and suggests how they may be applied more pragmatically in order to improve efficiency and reduce the waste of resources.

  11. Acceptance criteria for the evaluation of Category 1 fuel cycle facility physical security plans

    SciTech Connect

    Dwyer, P.A.

    1991-10-01

    This NUREG document presents criteria developed from US Nuclear Regulatory Commission regulations for the evaluation of physical security plans submitted by Category 1 fuel facility licensees. Category 1 refers to those licensees who use or possess a formula quantity of strategic special nuclear material.

  12. How strict should specimen acceptance or rejection criteria be for diagnostic semen analysis? An opinion.

    PubMed

    Woodward, Bryan J; Tomlinson, Mathew J

    2015-06-01

    Medical laboratory accreditation (previously by Clinical Pathology Accreditation UK Ltd and now by the United Kingdom Accreditation Service) has been integral to improving standards and service quality in the UK. With the recent introduction of the ISO15189 standard, all laboratories offering a clinical diagnostic service are required to demonstrate further improvement, with more emphasis on validation and assessment of the uncertainty levels associated with testing. This applies not only to 'bench testing', but also to the evidence-base for all pre-analytical and post-analytical procedures. To reduce the risk of external influences on andrology test results, semen sample rejection criteria were developed, including confirmation of patient identity, a strict time limit from sample production to testing, the use of toxicity-tested containers, a prescribed sexual abstinence and a need for complete sample collection. However, such criteria were originally developed by the World Health Organization in order to standardise analysis rather than reject testing outright, and should therefore be implemented with caution. Rejecting samples with normal semen parameters because they fail to meet some of the criteria as outlined above would be a waste of resources and adversely affect user (the person who requested or provided the sample) satisfaction. This document evaluates the evidence base underlying commonly used criteria for specimen rejection and suggests how they may be applied more pragmatically in order to improve efficiency and reduce the waste of resources. PMID:25292458

  13. Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods.

    PubMed

    Shanks, Orin C; Kelty, Catherine A; Oshiro, Robin; Haugland, Richard A; Madi, Tania; Brooks, Lauren; Field, Katharine G; Sivaganesan, Mano

    2016-05-01

    There is growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data quality across laboratories. Data quality is typically determined through a series of specifications that ensure good experimental practice and the absence of bias in the results due to DNA isolation and amplification interferences. However, there is currently a lack of consensus on how best to evaluate and interpret human fecal source identification qPCR experiments. This is, in part, due to the lack of standardized protocols and information on interlaboratory variability under conditions for data acceptance. The aim of this study is to provide users and reviewers with a complete series of conditions for data acceptance derived from a multiple laboratory data set using standardized procedures. To establish these benchmarks, data from HF183/BacR287 and HumM2 human-associated qPCR methods were generated across 14 laboratories. Each laboratory followed a standardized protocol utilizing the same lot of reference DNA materials, DNA isolation kits, amplification reagents, and test samples to generate comparable data. After removal of outliers, a nested analysis of variance (ANOVA) was used to establish proficiency metrics that include lab-to-lab, replicate testing within a lab, and random error for amplification inhibition and sample processing controls. Other data acceptance measurements included extraneous DNA contamination assessments (no-template and extraction blank controls) and calibration model performance (correlation coefficient, amplification efficiency, and lower limit of quantification). To demonstrate the implementation of the proposed standardized protocols and data acceptance criteria, comparable data from two additional laboratories were reviewed. The data acceptance criteria

  14. Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods

    PubMed Central

    Kelty, Catherine A.; Oshiro, Robin; Haugland, Richard A.; Madi, Tania; Brooks, Lauren; Field, Katharine G.; Sivaganesan, Mano

    2016-01-01

    There is growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data quality across laboratories. Data quality is typically determined through a series of specifications that ensure good experimental practice and the absence of bias in the results due to DNA isolation and amplification interferences. However, there is currently a lack of consensus on how best to evaluate and interpret human fecal source identification qPCR experiments. This is, in part, due to the lack of standardized protocols and information on interlaboratory variability under conditions for data acceptance. The aim of this study is to provide users and reviewers with a complete series of conditions for data acceptance derived from a multiple laboratory data set using standardized procedures. To establish these benchmarks, data from HF183/BacR287 and HumM2 human-associated qPCR methods were generated across 14 laboratories. Each laboratory followed a standardized protocol utilizing the same lot of reference DNA materials, DNA isolation kits, amplification reagents, and test samples to generate comparable data. After removal of outliers, a nested analysis of variance (ANOVA) was used to establish proficiency metrics that include lab-to-lab, replicate testing within a lab, and random error for amplification inhibition and sample processing controls. Other data acceptance measurements included extraneous DNA contamination assessments (no-template and extraction blank controls) and calibration model performance (correlation coefficient, amplification efficiency, and lower limit of quantification). To demonstrate the implementation of the proposed standardized protocols and data acceptance criteria, comparable data from two additional laboratories were reviewed. The data acceptance criteria

  15. How do the Properties of Allan Hills 84001 Compare With Accepted Criteria for Evidence of Ancient Life?

    NASA Technical Reports Server (NTRS)

    Gibson, E. K., Jr.; McKay, D. S.; Thomas-Keprta, K.; Westall, F.; Romanek, C. A.

    1998-01-01

    Criteria for Past Life: To be confident that any sample contains evidence of past life or biogenic activity, one must determine beyond a shadow of a doubt that certain well-established features or biomarker signatures are present in the sample. In the case of martian samples, the criteria for past life have not been established because if life existed on the planet, we have no way of knowing its detailed characteristics. Lacking independent evidence about the nature of possible past life on Mars, the scientific community must use, for the time being, the criteria established for ancient samples from the Earth: (1) Do we know the geologic context of the sample? Is it compatible with past life? (2) Do we know the age of the sample and its stratigraphic location? Are they understood enough to relate possible life to geologic history? (3) Does the sample contain evidence of cellular morphology? (4) What structural remains of colonies or communities exist within the samples? (5) Is there any evidence of biominerals showing chemical or mineral disequilibria? (6) Is there any evidence of stable isotope patterns unique to biology? (7) Are there any organic biomarkers present? (8) Are the features indigenous to the sample? For acceptance of past life in a geologic sample, essentially all of these criteria must he met.

  16. Radioactive waste management: review on clearance levels and acceptance criteria legislation, requirements and standards.

    PubMed

    Maringer, F J; Suráň, J; Kovář, P; Chauvenet, B; Peyres, V; García-Toraño, E; Cozzella, M L; De Felice, P; Vodenik, B; Hult, M; Rosengård, U; Merimaa, M; Szücs, L; Jeffery, C; Dean, J C J; Tymiński, Z; Arnold, D; Hinca, R; Mirescu, G

    2013-11-01

    In 2011 the joint research project Metrology for Radioactive Waste Management (MetroRWM)(1) of the European Metrology Research Programme (EMRP) started with a total duration of three years. Within this project, new metrological resources for the assessment of radioactive waste, including their calibration with new reference materials traceable to national standards will be developed. This paper gives a review on national, European and international strategies as basis for science-based metrological requirements in clearance and acceptance of radioactive waste.

  17. Tissue dissociation enzymes for isolating human islets for transplantation: factors to consider in setting enzyme acceptance criteria.

    PubMed

    McCarthy, Robert C; Breite, Andrew G; Green, Michael L; Dwulet, Francis E

    2011-01-27

    Tissue dissociation enzymes are critical reagents that affect the yield and quality of human pancreatic islets required for islet transplantation. The United States Food and Drug Administration's oversight of this procedure recommends laboratories to set acceptance criteria for enzymes used in the manufacture of islet products for transplantation. Currently, many laboratories base this selection on personal experience because biochemical analysis is not predictive of success of the islet isolation procedure. This review identifies the challenges of correlating results from enzyme biochemical analysis to their effectiveness in human islet isolation and suggests a path forward to address these challenges to improve control of the islet manufacturing process.

  18. Prototype Training Materials for Acceptance Criteria of Maintenance ASAP Events Occurring Within Social Context

    NASA Technical Reports Server (NTRS)

    Taylor, J. C.

    2004-01-01

    The aviation maintenance community is at a crossroads with respect to implementing the Aviation Safety Action Program (ASAP). While there is considerable interest, several key issues have emerged that cast doubt on how to assure a successful implementation, including buy-in from all levels of the company and training for key participants. There are two objectives for the present report. The first is to provide an examination of limits (or more properly, examples) of the degree of acceptability of more problematic events for risk-based decisions within the current ASAP guidelines. The second objective is to apply these limits of community standards to a set of further refined ASAP training scenarios.

  19. Building Energy Simulation Test for Existing Homes (BESTEST-EX): Instructions for Implementing the Test Procedure, Calibration Test Reference Results, and Example Acceptance-Range Criteria

    SciTech Connect

    Judkoff, R.; Polly, B.; Bianchi, M.; Neymark, J.; Kennedy, M.

    2011-08-01

    This publication summarizes building energy simulation test for existing homes (BESTEST-EX): instructions for implementing the test procedure, calibration tests reference results, and example acceptance-range criteria.

  20. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.

    PubMed

    McKee, Ann C; Cairns, Nigel J; Dickson, Dennis W; Folkerth, Rebecca D; Keene, C Dirk; Litvan, Irene; Perl, Daniel P; Stein, Thor D; Vonsattel, Jean-Paul; Stewart, William; Tripodis, Yorghos; Crary, John F; Bieniek, Kevin F; Dams-O'Connor, Kristen; Alvarez, Victor E; Gordon, Wayne A

    2016-01-01

    Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. As the first part of a series of consensus panels funded by the NINDS/NIBIB to define the neuropathological criteria for CTE, preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer's disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam. The results demonstrated that there was good agreement among the neuropathologists who reviewed the cases (Cohen's kappa, 0.67) and even better agreement between reviewers and the diagnosis of CTE (Cohen's kappa, 0.78). Based on these results, the panel defined the pathognomonic lesion of CTE as an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern. The group also defined supportive but non-specific p-tau-immunoreactive features of CTE as: pretangles and NFTs affecting superficial layers (layers II-III) of cerebral cortex; pretangles, NFTs or extracellular tangles in CA2 and pretangles and proximal dendritic swellings in CA4 of the hippocampus; neuronal and astrocytic aggregates in subcortical nuclei; thorn-shaped astrocytes at the glial limitans of the subpial and periventricular regions; and large grain-like and dot-like structures. Supportive non-p-tau pathologies include TDP-43 immunoreactive neuronal cytoplasmic inclusions and dot-like structures in the hippocampus, anteromedial temporal cortex and amygdala. The panel also recommended a minimum blocking and staining scheme for pathological evaluation

  1. Criteria to Define a Pair-Ion Plasma and the Role of Electrons in its Nonlinear Dynamics

    SciTech Connect

    Saleem, Hamid

    2008-10-15

    Criteria to define a pure pair-ion (PI) plasma are presented. It is suggested that the lighter elements (like H and He) are suitable to produce PI plasmas. The observation of ion acoustic wave (IAW) in recent experiments with fullerene plasmas clearly indicates the presence of electrons in the system. A set of two coupled nonlinear differential equations are obtained for PI plasma dynamics. In moving frame, it can be reduced to a form similar to Hasegawa-Mima equation but it does not support drift waves.

  2. Genetic and demographic criteria for defining population units for conservation: The value of clear messages

    USGS Publications Warehouse

    Esler, Daniel; Iverson, S.A.; Rizzolo, D.J.

    2006-01-01

    In a recent paper on Harlequin Duck (Histrionicus histrionicus) interannual site fidelity (Iverson et al. 2004), we concluded that wintering populations were demographically structured at a finer geographic scale than that at which genetic differentiation was observed and that conservation efforts should recognize this degree of demographic independence. In a critique of our study, Pearce and Talbot (2006) contend that our measures of fidelity were not robust and imply that in the face of "mixed messages" we failed to appreciate the role of genetic data in defining population units. We recognize, as we did in our original paper, that our methods for quantifying site fidelity have some limitations; however, the patterns in our data are consistent with a considerable body of literature indicating high winter site fidelity in Harlequin Ducks. Moreover, we do not consider differences in the scales at which genetic and demographic structure are expressed to be "mixed messages," given the different spatial and temporal scales at which genetic and contemporary demographic processes operate. We emphasize that a lack of genetic differentiation does not necessarily preclude the existence of contemporary demographic structure with relevance for conservation. ?? The Cooper Ornithological Society 2006.

  3. Criteria for acceptance to preprofessional dietetics programs vs desired qualities of professionals: an analysis.

    PubMed

    Moore, K K

    1995-01-01

    The objectives of this analysis were to examine the literature and compare and contrast (a) qualities preferred in preprofessional dietetics students by directors of internships and approved preprofessional practice programs (AP4s), (b) characteristics needed to succeed in a scientific field, (c) traits emphasized by dietetics training programs compared with those most valued by employers, (d) skills needed by high-level managerial dietitians and those in business and communications, and (e) qualities dietitians have aspired to develop for increased competitiveness in the marketplace. Even though the revised Standards of Education have been in place since 1988, recent evaluation of criteria for internship and AP4 admission has shown traditional emphasis on academic performance and the importance of work experience. Success in scientific pursuits has been linked with more than innate intelligence; a drive for success and enthusiasm for learning are also involved. Internships foster mostly technical learning, so development of skills in human and conceptual areas are somewhat lacking. These skills, which have been identified as valuable to employers, need greater development or more consistent identification in the selection and training process. Perhaps serious consideration should be given to applicants for preprofessional programs who have shown leadership qualities through extracurricular activities or who have given themselves the opportunity to develop and improve these skills. Such students might hasten the metamorphosis of dietetics practitioners toward improved levels of compensation and professional fulfillment. PMID:7798584

  4. Criteria for acceptance to preprofessional dietetics programs vs desired qualities of professionals: an analysis.

    PubMed

    Moore, K K

    1995-01-01

    The objectives of this analysis were to examine the literature and compare and contrast (a) qualities preferred in preprofessional dietetics students by directors of internships and approved preprofessional practice programs (AP4s), (b) characteristics needed to succeed in a scientific field, (c) traits emphasized by dietetics training programs compared with those most valued by employers, (d) skills needed by high-level managerial dietitians and those in business and communications, and (e) qualities dietitians have aspired to develop for increased competitiveness in the marketplace. Even though the revised Standards of Education have been in place since 1988, recent evaluation of criteria for internship and AP4 admission has shown traditional emphasis on academic performance and the importance of work experience. Success in scientific pursuits has been linked with more than innate intelligence; a drive for success and enthusiasm for learning are also involved. Internships foster mostly technical learning, so development of skills in human and conceptual areas are somewhat lacking. These skills, which have been identified as valuable to employers, need greater development or more consistent identification in the selection and training process. Perhaps serious consideration should be given to applicants for preprofessional programs who have shown leadership qualities through extracurricular activities or who have given themselves the opportunity to develop and improve these skills. Such students might hasten the metamorphosis of dietetics practitioners toward improved levels of compensation and professional fulfillment.

  5. Acceptance criteria for interim dry storage of aluminum-clad fuels

    SciTech Connect

    Sindelar, R.L.; Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-12-31

    Direct repository disposal of foreign and domestic research reactor fuels owned by the United States Department of Energy is an alternative to reprocessing (together with vitrification of the high level waste and storage in an engineered barrier) for ultimate disposition. Neither the storage systems nor the requirements and specifications for acceptable forms for direct repository disposal have been developed; therefore, an interim storage strategy is needed to safely store these fuels. Dry storage (within identified limits) of the fuels received from wet-basin storage would avoid excessive degradation to assure post-storage handleability, a full range of ultimate disposal options, criticality safety, and provide for maintaining confinement by the fuel/clad system. Dry storage requirements and technologies for US commercial fuels, specifically zircaloy-clad fuels under inert cover gas, are well established. Dry storage requirements and technologies for a system with a design life of 40 years for dry storage of aluminum-clad foreign and domestic research reactor fuels are being developed by various groups within programs sponsored by the DOE.

  6. Mechanisms of hyoid bone fracture after modelling: evaluation of anthropological criteria defining two relevant models.

    PubMed

    Pollard, J; Piercecchi-Marti, M D; Thollon, L; Bartoli, C; Adalian, Pascal; Bécart-Robert, A; Tournel, G; Hédouin, V; Panuel, M; Gosset, D; Leonetti, G

    2011-10-10

    Several studies have attempted to describe the morphology of the hyoid bone, while other authors have focused on discovering the role of this bone in the occurrence of fractures. Hyoid fractures are known to be dependent on the force applied against the bone, or on the location at which the force is applied. We wished to assess the value of defining one or more models of the hyoid bone by analyzing variations in the size and angle of the various component parts of the bone relative to the sex and morphology of an individual (height and weight) in a sample of 72 bones obtained during forensic autopsy at our institution. Statistical analyses were developed using SAS software (Statistical Analysis System, version 9.2). We observed that the length of the hyoid bone and the angle between the greater horns differed significantly between men and women. Length was significantly greater in men (38.20 ± 4.67 mm) than in women (30.49 ± 7.90 mm) and the angle between the greater horns of the hyoid bone was larger in women (36.46 ± 13.77°) than in men (27.56 ± 13.02°). There was also a statistically significant correlation between the body mass index of an individual and the length of the hyoid bone. As weight increased, the hyoid bone was found to be longer. The weight of an individual was also significantly correlated with the angle of the hyoid bone, with lower weight resulting in larger angles of the bone. Furthermore, hierarchical classification enabled the hyoid bone to be differentiated into two groups or clusters according to anthropometric measurements. ROC curves were used to determine threshold values of length, width and angle to classify the hyoid bones in these two clusters: the first was composed of individuals with longer hyoid bones, and the second of individuals with greater hyoid bone widths and wider angles. Logistic regression showed male gender was more frequently associated with the first group. The morphology of the hyoid bone can be differentiated

  7. EU landfill waste acceptance criteria and EU Hazardous Waste Directive compliance testing of incinerated sewage sludge ash.

    PubMed

    Donatello, S; Tyrer, M; Cheeseman, C R

    2010-01-01

    A hazardous waste assessment has been completed on ash samples obtained from seven sewage sludge incinerators operating in the UK, using the methods recommended in the EU Hazardous Waste Directive. Using these methods, the assumed speciation of zinc (Zn) ultimately determines if the samples are hazardous due to ecotoxicity hazard. Leaching test results showed that two of the seven sewage sludge ash samples would require disposal in a hazardous waste landfill because they exceed EU landfill waste acceptance criteria for stabilised non-reactive hazardous waste cells for soluble selenium (Se). Because Zn cannot be proven to exist predominantly as a phosphate or oxide in the ashes, it is recommended they be considered as non-hazardous waste. However leaching test results demonstrate that these ashes cannot be considered as inert waste, and this has significant implications for the management, disposal and re-use of sewage sludge ash.

  8. Establishment of design criteria for acceptable failure modes and fail safe considerations for the space shuttle structural system

    NASA Technical Reports Server (NTRS)

    Westrup, R. W.

    1972-01-01

    Investigations of fatigue life, and safe-life and fail-safe design concepts as applied to space shuttle structure are summarized. The results are evaluated to select recommended structural design criteria to provide assurance that premature failure due to propagation of undetected crack-like defects will not occur during shuttle operational service. The space shuttle booster, GDC configuration B-9U, is selected as the reference vehicle. Structural elements used as basis of detail analyses include wing spar caps, vertical stabilizer skins, crew compartment skin, orbiter support frame, and propellant tank shell structure. Fatigue life analyses of structural elements are performed to define potential problem areas and establish upper limits of operating stresses. Flaw growth analyses are summarized in parametric form over a range of initial flaw types and sizes, operating stresses and service life requirements. Service life of 100 to 500 missions is considered.

  9. A proposed rationale and test methodology for establishment of acceptance criteria for vacuum integrity testing of pharmaceutical freeze dryers.

    PubMed

    Hardwick, Lisa M; Nail, Steven L; Jarman, James; Hasler, Kai; Hense, Thomas

    2013-10-01

    A scientific rationale is proposed for the establishment of acceptance criteria for leak rates in pharmaceutical freeze dryers. A method was developed to determine the quantity of air that could leak into any lyophilizer from the outside while still maintaining Class 100/Grade A microbial conditions. A lyophilizing product is assumed most vulnerable to microbial contamination during secondary drying, when mass transfer of water vapor from product to condenser is minimal. Using the void volume of the dryer, calculated from change in internal pressure when a known volume of air is introduced, and the potential maximum bioburden of the leaked air (based on measured values), calculations can determine the allowable leaked volume of air, the flow rate required to admit that volume in a given time frame, and the pressure rise that would result from the leak over a given testing period. For the dryers in this study, using worst-case air quality conditions, it was determined that a leak resulting in a pressure rise of 0.027 mbar over a 30 min period would allow the dryers to remain in secondary drying conditions for 62 h before the established action level of one colony forming unit for each cubic meter of air space would be reached.

  10. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees)...

  11. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees)...

  12. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees)...

  13. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR...

  14. 16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR...

  15. Defining the Utility of Clinically Acceptable Variations in Evidence-Based Practice Guidelines for Evaluation of Quality Improvement Activities.

    ERIC Educational Resources Information Center

    Lescoe-Long, Mary; Long, Michael J.

    1999-01-01

    Examined the usefulness of systematically accounting for acceptable physician variations in guideline application. Review of 141 cases of treatment of acute myocardial infarction in a Canadian hospital show that even seemingly noncontentious guideline protocols do not offer a threshold of variation similar to conventional Continuous Quality…

  16. Structural acceptance criteria for the evaulation of existing double-shell waste storage tanks located at the Hanford site, Richland, Washington

    SciTech Connect

    Julyk, L.J.; Day, A.D.; Dyrness, A.D.; Moore, C.J.; Peterson, W.S.; Scott, M.A.; Shrivastava, H.P.; Sholman, J.S.; Watts, T.N.

    1995-09-01

    The structural acceptance criteria contained herein for the evaluation of existing underground double-shell waste storage tanks located at the Hanford Site is part of the Life Management/Aging Management Program of the Tank Waste Remediation System. The purpose of the overall life management program is to ensure that confinement of the waste is maintained over the required service life of the tanks. Characterization of the present condition of the tanks, understanding and characterization of potential degradation mechanisms, and development of tank structural acceptance criteria based on previous service and projected use are prerequisites to assessing tank integrity, to projecting the length of tank service, and to developing and applying prudent fixes or repairs. The criteria provided herein summarize the requirements for the analysis and structural qualification of the existing double-shell tanks for continued operation. Code reconciliation issues and material degradation under aging conditions are addressed. Although the criteria were developed for double-shell tanks, many of the provisions are equally applicable to single-shell tanks. However, the criteria do not apply to the evaluation of tank appurtenances and buried piping.

  17. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the “Borda” Method: a Pilot Study

    PubMed Central

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran’s public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called “Borda” in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software “Math-lab”7, “SPSS” 17 and Excel 2007 were used in this study. “Borda” estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance

  18. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the "Borda" Method: a Pilot Study.

    PubMed

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran's public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called "Borda" in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software "Math-lab"7, "SPSS" 17 and Excel 2007 were used in this study. "Borda" estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance decision making.

  19. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the "Borda" Method: a Pilot Study.

    PubMed

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran's public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called "Borda" in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software "Math-lab"7, "SPSS" 17 and Excel 2007 were used in this study. "Borda" estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance decision making

  20. Assessment of the European classification criteria for Sjögren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjögren's Syndrome.

    PubMed Central

    Vitali, C; Bombardieri, S; Moutsopoulos, H M; Coll, J; Gerli, R; Hatron, P Y; Kater, L; Konttinen, Y T; Manthorpe, R; Meyer, O; Mosca, M; Ostuni, P; Pellerito, R A; Pennec, Y; Porter, S R; Richards, A; Sauvezie, B; Schiødt, M; Sciuto, M; Shoenfeld, Y; Skopouli, F N; Smolen, J S; Soromenho, F; Tishler, M; Wattiaux, M J

    1996-01-01

    OBJECTIVE: To assess the recently proposed preliminary criteria for the classification of Sjögren's syndrome (SS) in a multicentre European study of a new series of clinically defined cases. METHODS: The criteria included six items: I = ocular symptoms; II = oral symptoms; III = evidence of keratoconjunctivitis sicca; IV = focal sialoadenitis by minor salivary gland biopsy; V = instrumental evidence of salivary gland involvement; VI = presence of autoantibodies. Each centre was asked to provide five patients with primary SS, five with secondary SS, five with connective tissue diseases (CTD) but without SS, and five controls (patients with ocular or oral features that may simulate SS). The preliminary six item classification criteria set was applied to both the SS patients and the non-SS controls, and the performance of the criteria in terms of sensitivity and specificity was tested. RESULTS: The criteria set was tested on a total of 278 cases (157 SS patients and 121 non-SS controls) collected from 16 centres in 10 countries. At least four of the six items in the criteria set (limiting item VI to the presence of Ro(SS-A) or La(SS-B) antibodies) were present in 79 of 81 patients initially classified as having primary SS (sensitivity 97.5%), but in only seven of 121 non-SS controls (specificity 94.2%). When the presence of item I or II plus any two of items III-V of the criteria set was considered as indicative of secondary SS, 97.3% (71 of 73) of the patients initially defined as having this disorder and 91.8% (45 of 49) of the control patients with CTD without SS were correctly classified. CONCLUSION: This prospective study confirmed the high validity and reliability of the classification criteria for SS recently proposed by the European Community Study Group. PMID:8712861

  1. Clinical relevance of surgical site infection as defined by the criteria of the Centers for Disease Control and Prevention.

    PubMed

    Henriksen, N A; Meyhoff, C S; Wetterslev, J; Wille-Jørgensen, P; Rasmussen, L S; Jorgensen, L N

    2010-07-01

    Surgical site infection (SSI) is a common complication after abdominal surgery and the Centers for Disease Control and Prevention (CDC) criteria are commonly used for diagnosis and surveillance. The aim of this study was to evaluate whether SSI diagnosed according to CDC is clinically relevant (CRSSI) and whether there is agreement between evaluations according to the CDC criteria, the ASEPSIS score (Additional treatment, presence of Serous discharge, Erythema, Purulent exudate, Separation of the deep tissues, Isolation of bacteria and duration of Stay) and CRSSI. We included 54 patients diagnosed with SSI and a matched control group (N=46) without SSI according to the CDC criteria after laparotomy. Two blinded experienced surgeons evaluated the hospital records and determined whether patients had CRSSI, based on the following criteria: antibiotic treatment, surgical intervention, prolonged hospital stay or referral to an intensive care unit for SSI. The rate of CRSSI was 38 of 54 (70%) in patients with CDC-diagnosed SSI and none in patients without a CDC-diagnosed SSI. Sixty-one percent of the CDC-diagnosed SSIs were superficial, of which 48% were considered clinically relevant. There was substantial agreement between the CDC criteria and CRSSI [kappa=0.69; 95% confidence interval (CI): 0.55-0.83] and fair agreement between the ASEPSIS score and the CDC criteria (kappa=0.23; 95% CI: 0-0.49) and between the ASEPSIS score and CRSSI (kappa=0.39; 95% CI: 0.17-0.61). The CDC criteria represent a suitable standard definition for monitoring and identifying SSI, even if some cases of less clinically significant superficial SSI are included.

  2. 40 CFR 86.610-98 - Compliance with acceptable quality level and passing and failing criteria for Selective...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Selective Enforcement Auditing of New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.610-98 Compliance with acceptable quality...

  3. 20 CFR 718.204 - Total disability and disability causation defined; criteria for determining total disability and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., based on medically acceptable clinical and laboratory diagnostic techniques, concludes that a miner's... evidence may be used in the following cases: (1) In a case involving a deceased miner in which the claim... the miner's pulmonary or respiratory condition. (2) In a case involving a survivor's claim filed on...

  4. Defining optimal cutoff scores for cognitive impairment using Movement Disorder Society Task Force criteria for mild cognitive impairment in Parkinson's disease.

    PubMed

    Goldman, Jennifer G; Holden, Samantha; Bernard, Bryan; Ouyang, Bichun; Goetz, Christopher G; Stebbins, Glenn T

    2013-12-01

    The recently proposed Movement Disorder Society (MDS) Task Force diagnostic criteria for mild cognitive impairment in Parkinson's disease (PD-MCI) represent a first step toward a uniform definition of PD-MCI across multiple clinical and research settings. However, several questions regarding specific criteria remain unanswered, including optimal cutoff scores by which to define impairment on neuropsychological tests. Seventy-six non-demented PD patients underwent comprehensive neuropsychological assessment and were classified as PD-MCI or PD with normal cognition (PD-NC). The concordance of PD-MCI diagnosis by MDS Task Force Level II criteria (comprehensive assessment), using a range of standard deviation (SD) cutoff scores, was compared with our consensus diagnosis of PD-MCI or PD-NC. Sensitivity, specificity, and positive and negative predictive values were examined for each cutoff score. PD-MCI subtype classification and distribution of cognitive domains impaired were evaluated. Concordance for PD-MCI diagnosis was greatest for defining impairment on neuropsychological tests using a 2 SD cutoff score below appropriate norms. This cutoff also provided the best discriminatory properties for separating PD-MCI from PD-NC compared with other cutoff scores. With the MDS PD-MCI criteria, multiple domain impairment was more frequent than single domain impairment, with predominant executive function, memory, and visuospatial function deficits. Application of the MDS Task Force PD-MCI Level II diagnostic criteria demonstrates good sensitivity and specificity at a 2 SD cutoff score. The predominance of multiple domain impairment in PD-MCI with the Level II criteria suggests not only influences of testing abnormality requirements, but also the widespread nature of cognitive deficits within PD-MCI.

  5. 40 CFR 89.510 - Compliance with acceptable quality level and passing and failing criteria for selective...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... level and passing and failing criteria for selective enforcement audits. 89.510 Section 89.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Selective Enforcement Auditing §...

  6. 40 CFR 91.608 - Compliance with acceptable quality level and passing and failing criteria for selective...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... level and passing and failing criteria for selective enforcement audits. 91.608 Section 91.608 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Selective Enforcement Auditing Regulations § 91.608...

  7. 40 CFR 91.608 - Compliance with acceptable quality level and passing and failing criteria for selective...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... level and passing and failing criteria for selective enforcement audits. 91.608 Section 91.608 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Selective Enforcement Auditing Regulations § 91.608...

  8. 40 CFR 89.510 - Compliance with acceptable quality level and passing and failing criteria for selective...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... level and passing and failing criteria for selective enforcement audits. 89.510 Section 89.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Selective Enforcement Auditing §...

  9. A FRAMEWORK TO DEVELOP FLAW ACCEPTANCE CRITERIA FOR STRUCTURAL INTEGRITY ASSESSMENT OF MULTIPURPOSE CANISTERS FOR EXTENDED STORAGE OF USED NUCLEAR FUEL

    SciTech Connect

    Lam, P.; Sindelar, R.; Duncan, A.; Adams, T.

    2014-04-07

    A multipurpose canister (MPC) made of austenitic stainless steel is loaded with used nuclear fuel assemblies and is part of the transfer cask system to move the fuel from the spent fuel pool to prepare for storage, and is part of the storage cask system for on-site dry storage. This weld-sealed canister is also expected to be part of the transportation package following storage. The canister may be subject to service-induced degradation especially if exposed to aggressive environments during possible very long-term storage period if the permanent repository is yet to be identified and readied. Stress corrosion cracking may be initiated on the canister surface in the welds or in the heat affected zone because the construction of MPC does not require heat treatment for stress relief. An acceptance criteria methodology is being developed for flaw disposition should the crack-like defects be detected by periodic Inservice Inspection. The external loading cases include thermal accident scenarios and cask drop conditions with the contribution from the welding residual stresses. The determination of acceptable flaw size is based on the procedure to evaluate flaw stability provided by American Petroleum Institute (API) 579 Fitness-for-Service (Second Edition). The material mechanical and fracture properties for base and weld metals and the stress analysis results are obtained from the open literature such as NUREG-1864. Subcritical crack growth from stress corrosion cracking (SCC), and its impact on inspection intervals and acceptance criteria, is not addressed.

  10. Incidence, Predictors, and Impact on Hospital Mortality of Amphotericin B Nephrotoxicity Defined Using Newer Acute Kidney Injury Diagnostic Criteria

    PubMed Central

    Kobayashi, Carla Dinamérica; de Carvalho Almeida, Luna; de Oliveira dos Reis, Camilla; Santos, Barbara Mendes; Glesby, Marshall Jay

    2015-01-01

    Studies on amphotericin B (AmB) nephrotoxicity use diverse definitions of acute kidney injury (AKI). Here, we used the new Kidney Disease Improving Global Outcome (KDIGO) system to describe the incidence, predictors, and impact of AmB-induced AKI on hospital mortality in 162 patients treated with AmB (120 with deoxycholate preparation and 42 with liposomal preparation). KDIGO stage 1 requires an absolute increase of ≥0.3 mg/dl or ≥1.5× over baseline serum creatinine (SCr), while stage 2 requires ≥2×, and stage 3 requires ≥3×. A binary KDIGO definition (KDIGObin) corresponds to stage ≥1. For comparison, we included two definitions of AKI traditionally utilized in nephrotoxicity studies: ≥0.5 mg/dl (NT0.5) and ≥2× (NT2×) increase in baseline SCr. The overall incidence of AmB-induced AKI by KDIGObin was 58.6% (stage 1, 30.9%; stage 2, 18.5%; stage 3, 9.3%). Predictors of AKI by KDIGObin were older age and use of furosemide and angiotensin-converting enzyme inhibitor (ACE-I). Traditional criteria detected lower incidences of AKI, at 45.1% (NT0.5) and 27.8% (NT2×). Predictors of AKI by traditional criteria were older age and use of vancomycin (NT0.5) and use of vancomycin and vasopressors (NT2×). KDIGObin detected AKI 2 days earlier than the most sensitive traditional criterion. However, only traditional criteria were associated with intensive care unit (ICU) admission, mechanical ventilation, and mortality. In conclusion, the increase in sensitivity of KDIGObin is accompanied by a loss of specificity and ability to predict outcomes. Prospective studies are required to weigh the potential gain from early AKI detection against the potential loss from undue changes in management in patients with subtle elevations in SCr. PMID:26014956

  11. Quality of laboratory studies assessing effects of Bt-proteins on non-target organisms: minimal criteria for acceptability.

    PubMed

    De Schrijver, Adinda; Devos, Yann; De Clercq, Patrick; Gathmann, Achim; Romeis, Jörg

    2016-08-01

    The potential risks that genetically modified plants may pose to non-target organisms and the ecosystem services they contribute to are assessed as part of pre-market risk assessments. This paper reviews the early tier studies testing the hypothesis whether exposure to plant-produced Cry34/35Ab1 proteins as a result of cultivation of maize 59122 is harmful to valued non-target organisms, in particular Arthropoda and Annelida. The available studies were assessed for their scientific quality by considering a set of criteria determining their relevance and reliability. As a case-study, this exercise revealed that when not all quality criteria are met, weighing the robustness of the study and its relevance for risk assessment is not obvious. Applying a worst-case expected environmental concentration of bioactive toxins equivalent to that present in the transgenic crop, confirming exposure of the test species to the test substance, and the use of a negative control were identified as minimum criteria to be met to guarantee sufficiently reliable data. This exercise stresses the importance of conducting studies meeting certain quality standards as this minimises the probability of erroneous or inconclusive results and increases confidence in the results and adds certainty to the conclusions drawn.

  12. Quality of laboratory studies assessing effects of Bt-proteins on non-target organisms: minimal criteria for acceptability.

    PubMed

    De Schrijver, Adinda; Devos, Yann; De Clercq, Patrick; Gathmann, Achim; Romeis, Jörg

    2016-08-01

    The potential risks that genetically modified plants may pose to non-target organisms and the ecosystem services they contribute to are assessed as part of pre-market risk assessments. This paper reviews the early tier studies testing the hypothesis whether exposure to plant-produced Cry34/35Ab1 proteins as a result of cultivation of maize 59122 is harmful to valued non-target organisms, in particular Arthropoda and Annelida. The available studies were assessed for their scientific quality by considering a set of criteria determining their relevance and reliability. As a case-study, this exercise revealed that when not all quality criteria are met, weighing the robustness of the study and its relevance for risk assessment is not obvious. Applying a worst-case expected environmental concentration of bioactive toxins equivalent to that present in the transgenic crop, confirming exposure of the test species to the test substance, and the use of a negative control were identified as minimum criteria to be met to guarantee sufficiently reliable data. This exercise stresses the importance of conducting studies meeting certain quality standards as this minimises the probability of erroneous or inconclusive results and increases confidence in the results and adds certainty to the conclusions drawn. PMID:26980555

  13. AMERICAN JOINT COMMITTEE ON CANCER ACCEPTANCE CRITERIA FOR INCLUSION OF RISK MODELS FOR INDIVIDUALIZED PROGNOSIS IN THE PRACTICE OF PRECISION MEDICINE

    PubMed Central

    Kattan, Michael W.; Hess, Kenneth R.; Amin, Mahul; Lu, Ying; Moons, Karel G; Gershenwald, Jeffrey E.; Gimotty, Phyllis A.; Guinney, Justin; Halabi, Susan; Lazar, Alexander J.; Mahar, Alyson L.; Patel, Tushar; Sargent, Daniel J.; Weiser, Martin R.; Compton, Carolyn

    2016-01-01

    The American Joint Committee on Cancer (AJCC) has increasingly recognized the need for more personalized probabilistic predictions than those delivered by ordinal staging systems, particularly through the use of accurate risk models or calculators. However, judging the quality and acceptability of a risk model is complex. The AJCC Precision Medicine Core conducted a two-day meeting to discuss characteristics necessary for a quality risk model in cancer patients. More specifically, the committee established inclusion and exclusion criteria necessary for a risk model to potentially be endorsed by the AJCC. This committee reviewed and discussed relevant literature before creating a checklist unique to this need of AJCC risk model endorsement. The committee identified 13 inclusion and 3 exclusion criteria for AJCC risk model endorsement in cancer. The emphasis centered on performance metrics, implementation clarity, and clinical relevance. The facilitation of personalized probabilistic predictions for cancer patients holds tremendous promise, and these criteria will hopefully greatly accelerate this process. Moreover, these criteria might be useful for a general audience when trying to judge the potential applicability of a published risk model in any clinical domain. PMID:26784705

  14. Digital soil mapping for the support of delineation of Areas Facing Natural Constraints defined by common European biophysical criteria

    NASA Astrophysics Data System (ADS)

    Pásztor, László; Bakacsi, Zsófia; Laborczi, Annamária; Takács, Katalin; Szatmári, Gábor; Tóth, Tibor; Szabó, József

    2016-04-01

    One of the main objectives of the EU's Common Agricultural Policy is to encourage maintaining agricultural production in Areas Facing Natural Constraints (ANC) in order to sustain agricultural production and use natural resources, in such a way to secure both stable production and income to farmers and to protect the environment. ANC assignment has both ecological and severe economical aspects. Recently the delimitation of ANCs is suggested to be carried out by using common biophysical diagnostic criteria on low soil productivity and poor climate conditions all over Europe. The criterion system was elaborated and has been repeatedly upgraded by JRC. The operational implementation is under member state competence. This process requires application of available soil databases and proper thematic and spatial inference methods. In our paper we present the inferences applied for the latest identification and delineation of areas with low soil productivity in Hungary according to JRC biophysical criteria related to soil: limited soil drainage, texture and stoniness (coarse texture, heavy clay, vertic properties), shallow rooting depth, chemical properties (salinity, sodicity, low pH). The compilation of target specific maps were based on the available legacy and recently collected data. In the present work three different data sources were used. The most relevant available data were queried from the datasets for each mapped criterion for either direct application or for the compilation a suitable, synthetic (non-measured) parameter. In some cases the values of the target variable originated from only one, in other cases from more databases. The reference dataset used in the mapping process was set up after substantial statistical analysis and filtering. It consisted of the values of the target variable attributed to the finally selected georeferenced locations. For spatial inference regression kriging was applied. Accuracy assessment was carried out by Leave One Out

  15. What is the impact of different spirometric criteria on the prevalence of spirometrically defined COPD and its comorbidities? Results from the population-based KORA study

    PubMed Central

    Karrasch, Stefan; Brüske, Irene; Smith, Maia P; Thorand, Barbara; Huth, Cornelia; Ladwig, Karl-Heinz; Kronenberg, Florian; Heinrich, Joachim; Holle, Rolf; Peters, Annette; Schulz, Holger

    2016-01-01

    Background There is an ongoing debate about the appropriate spirometric criterion for airway obstruction to detect COPD. Furthermore, the association of different criteria with comorbidity prevalence and inflammatory biomarkers in advanced age is unclear. Materials and methods Spirometry was performed in a population-based study (n=2,256) covering an age range of 41–90 years. COPD was spirometrically determined either by a fixed ratio (FR) of <0.7 for forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) or by FEV1/FVC below the lower limit of normal (LLN). Comorbidity prevalences and circulating biomarker levels (C-reactive protein [CRP], interleukin [IL]-6) were compared between subjects with or without COPD by the two criteria using logistic and multiple regression models, adjusting for sex and age. Results The prevalence of spirometrically defined COPD by FR increased with age from 10% in subjects aged <65 years to 26% in subjects aged ≥75 years. For LLN-defined COPD, it remained below 10% for all age groups. Overall, COPD diagnosis was not associated with specific comorbidities, except for a lower prevalence of obesity in both FR- and LLN-defined cases. Both CRP and IL-6 tended to be higher in cases by both criteria. Conclusion In a population-based cohort of adults up to the age of 90 years, the prevalence of spirometrically defined COPD was higher for the FR criterion than for the LLN criterion. This difference increased with age. Neither prevalences of common comorbidities nor levels of the biomarkers, CRP or IL-6, were conclusively associated with the selection of the COPD criterion. Results have to be considered in light of the predominantly mild cases of airway obstruction in the examined study population. PMID:27574413

  16. Development of acceptance criteria for batches of silane primer for external tank thermal protection system bonding applications

    NASA Technical Reports Server (NTRS)

    Mikes, F.

    1985-01-01

    Fourier transform infrared spectroscopy is currently the best technique for observing hydrolytic changes in DC 1200 silane the primers caused by moisture in the atmosphere. To further prove that FTIR can be used as a criterion test for acceptance of silane primer lots, intensities of the FTIR OH- band are being compared with primer adhesive bond strength using a mechanical test suggested by NASA. Results of tests for shear strength and Oh-absorption are tabulated and compared with FTIR absorption intensities in the OH-region.

  17. Data Quality Objectives and Criteria for Basic Information, Acceptable Uncertainty, and Quality-Assurance and Quality-Control Documentation

    USGS Publications Warehouse

    Granato, Gregory E.; Bank, Fred G.; Cazenas, Patricia A.

    1998-01-01

    The Federal Highway Administration and State transportation agencies have the responsibility of determining and minimizing the effects of highway runoff on water quality; therefore, they have been conducting an extensive program of water-quality monitoring and research during the last 25 years. The objectives and monitoring goals of highway runoff studies have been diverse, because the highway community must address many different questions about the characteristics and impacts of highway runoff. The Federal Highway Administration must establish that available data and procedures that are used to assess and predict pollutant loadings and impacts from highway stormwater runoff are valid, current, and technically supportable. This report examines criteria for evaluating water-quality data and resultant interpretations. The criteria used to determine if data are valid (useful for intended purposes), current, and technically supportable are derived from published materials from the Federal Highway Administration, the U.S. Environmental Protection Agency, the Intergovernmental Task Force on Monitoring Water Quality, the U.S. Geological Survey and from technical experts throughout the U.S. Geological Survey. Water-quality data that are documented to be meaningful, representative, complete, precise, accurate, comparable, and admissible as legal evidence will meet the scientific, engineering, and regulatory needs of highway agencies. Documentation of basic information, such as compatible monitoring objectives and program design features; metadata (when, where, and how data were collected as well as who collected and analyzed the data); ancillary information (explanatory variables and study-site characteristics); and legal requirements are needed to evaluate data. Documentation of sufficient quality-assurance and quality-control information to establish the quality and uncertainty in the data and interpretations also are needed to determine the comparability and utility of

  18. Assessment of the orthogonality in two-dimensional separation systems using criteria defined by the maximal information coefficient.

    PubMed

    Mani-Varnosfaderani, Ahmad; Ghaemmaghami, Mostafa

    2015-10-01

    A novel method based on the maximal information coefficient (MIC) is developed to assess the orthogonality of comprehensive two-dimensional separation systems. The proposed method is based on a modification of Marriott's method, which was previously reported in 2013. Marriott's method relies on the calculation of two separate parameters. The first term is Cpert which defines the peak coverage percent in separation space, and the second is Cpeaks which corresponds to 2-D distribution correlation of the peaks. Marriott's method for estimating the values of Cpeaks is based on the calculation of the coefficient of determination (R(2)) between the retention indices of the peaks. Herein, we present some examples where R(2) is an inefficient way to estimate the values of Cpeaks. The results in this work illustrate that when there are either functional or non-functional local dependencies between the distributions of the peaks, R(2) values fail to thoroughly estimate the values of Cpeaks. We proposed using the MIC instead of R(2) to estimate the values of Cpeaks for orthogonality calculations. Simulations of comprehensive two-dimensional gas chromatograms were performed using the Abraham solvation parameter model in order to generate examples for orthogonality assessment. The results indicate that the suggested modifications in this work correct the shortcomings of Marriott's model, and the proposed equation accurately measures the column dependencies in 2-D separation systems. PMID:26343539

  19. Cleaning level acceptance criteria and a high pressure liquid chromatography procedure for the assay of Meclizine Hydrochloride residue in swabs collected from pharmaceutical manufacturing equipment surfaces.

    PubMed

    Mirza, T; Lunn, M J; Keeley, F J; George, R C; Bodenmiller, J R

    1999-04-01

    A method using pharmacologically based and visual limit of detection criteria to determine the acceptable residue level for Meclizine Hydrochloride (MH) on pharmaceutical manufacturing equipment surfaces after cleaning is described. A formula was used in order to determine the pharmacologically safe cleaning level for MH. This level was termed as specific residual cleaning Level (SRCL) and calculated to be 50 microg 100 cm(-2). The visual limit of detection (VLOD) was determined by spiking different levels of MH on stainless steel plates and having the plates examined by a group of observers. The lowest level that could be visually detected by the majority of the observers, 62.5 microg 100 cm(-2), was considered as the VLOD for MH. The lower of the SRCL and VLOD values, i.e. 50 microg 100 cm(-2), was therefore chosen as the cleaning acceptance criterion. A sensitive reversed-phase HPLC method was developed and validated for the assay of MH in swabs used to test equipment surfaces. Using this method, the mean recoveries of MH from spiked swabs and '180-Grit' stainless steel plates were 87.0 and 89.5% with relative standard deviations (RSD) of +/- 3.3 and +/- 2.4%, respectively. The method was successfully applied to the assay of actual swab samples collected from the equipment surfaces. The stability of MH on stainless steel plates, on cleaning swabs and in the extraction solution was investigated. PMID:10698538

  20. Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force.

    PubMed

    Strehl, Cindy; Bijlsma, Johannes W J; de Wit, Maarten; Boers, Maarten; Caeyers, Nele; Cutolo, Maurizio; Dasgupta, Bhaskar; Dixon, William G; Geenen, Rinie; Huizinga, Tom W J; Kent, Alison; de Thurah, Annette Ladefoged; Listing, Joachim; Mariette, Xavier; Ray, David W; Scherer, Hans U; Seror, Raphaèle; Spies, Cornelia M; Tarp, Simon; Wiek, Dieter; Winthrop, Kevin L; Buttgereit, Frank

    2016-06-01

    There is convincing evidence for the known and unambiguously accepted beneficial effects of glucocorticoids at low dosages. However, the implementation of existing recommendations and guidelines on the management of glucocorticoid therapy in rheumatic diseases is lagging behind. As a first step to improve implementation, we aimed at defining conditions under which long-term glucocorticoid therapy may have an acceptably low level of harm. A multidisciplinary European League Against Rheumatism task force group of experts including patients with rheumatic diseases was assembled. After a systematic literature search, breakout groups critically reviewed the evidence on the four most worrisome adverse effects of glucocorticoid therapy (osteoporosis, hyperglycaemia/diabetes mellitus, cardiovascular diseases and infections) and presented their results to the other group members following a structured questionnaire for final discussion and consensus finding. Robust evidence on the risk of harm of long-term glucocorticoid therapy was often lacking since relevant study results were often either missing, contradictory or carried a high risk of bias. The group agreed that the risk of harm is low for the majority of patients at long-term dosages of ≤5 mg prednisone equivalent per day, whereas at dosages of >10 mg/day the risk of harm is elevated. At dosages between >5 and ≤10 mg/day, patient-specific characteristics (protective and risk factors) determine the risk of harm. The level of harm of glucocorticoids depends on both dose and patient-specific parameters. General and glucocorticoid-associated risk factors and protective factors such as a healthy lifestyle should be taken into account when evaluating the actual and future risk. PMID:26933146

  1. Development of a tool for defining and identifying the dying patient in hospital: Criteria for Screening and Triaging to Appropriate aLternative care (CriSTAL)

    PubMed Central

    Cardona-Morrell, Magnolia; Hillman, Ken

    2015-01-01

    Objective To develop a screening tool to identify elderly patients at the end of life and quantify the risk of death in hospital or soon after discharge for to minimise prognostic uncertainty and avoid potentially harmful and futile treatments. Design Narrative literature review of definitions, tools and measurements that could be combined into a screening tool based on routinely available or obtainable data at the point of care to identify elderly patients who are unavoidably dying at the time of admission or at risk of dying during hospitalisation. Main measurements Variables and thresholds proposed for the Criteria for Screening and Triaging to Appropriate aLternative care (CriSTAL screening tool) were adopted from existing scales and published research findings showing association with either in-hospital, 30-day or 3-month mortality. Results Eighteen predictor instruments and their variants were examined. The final items for the new CriSTAL screening tool included: age ≥65; meeting ≥2 deterioration criteria; an index of frailty with ≥2 criteria; early warning score >4; presence of ≥1 selected comorbidities; nursing home placement; evidence of cognitive impairment; prior emergency hospitalisation or intensive care unit readmission in the past year; abnormal ECG; and proteinuria. Conclusions An unambiguous checklist may assist clinicians in reducing uncertainty patients who are likely to die within the next 3 months and help initiate transparent conversations with families and patients about end-of-life care. Retrospective chart review and prospective validation will be undertaken to optimise the number of prognostic items for easy administration and enhanced generalisability. Development of an evidence-based tool for defining and identifying the dying patient in hospital: CriSTAL. PMID:25613983

  2. European multicentre study to define disease activity criteria for systemic sclerosis.* I. Clinical and epidemiological features of 290 patients from 19 centres

    PubMed Central

    Della, R; Valentini, G; Bombardieri, S; Bencivelli, W; Silman, A; D'Angelo, S; Cerinic, M; Belch, J; Black, C; Becvar, R; Bruhlman, P; Cozzi, F; Czirjak, L; Drosos, A; Dziankowska, B; Ferri, C; Gabrielli, A; Giacomelli, R; Hayem, G; Inanc, M; McHugh, N; Nielsen, H; Scorza, R; Tirri, E; van den Hoogen, F H J; Vlachoyiannopoulo..., P

    2001-01-01

    OBJECTIVE—To investigate the existence of differences among European referral centres for systemic sclerosis (SSc) in the pattern of attendance and referral and in the clinical and therapeutical approaches.
METHODS—In 1995 the European Scleroderma Study Group initiated a multicentre prospective one year study whose aim was to define the disease activity criteria in SSc. During the study period each participating European centre was asked to enrol consecutive patients satisfying American College of Rheumatology criteria for SSc and to fill out for each of them a standardised clinical chart. Patients from various centres were compared and differences in epidemiological, clinical, and therapeutical aspects were analysed.
RESULTS—Nineteen different medical research centres consecutively recruited 290 patients. The patients could be divided into two subgroups: 173 with the limited (lSSc) and 117 with the diffuse (dSSc) form of the disease. The clinical and serological findings for the series of 290 patients seemed to be similar to data previously reported. However, when the data were analysed to elicit any differences between the participating centres, a high degree of variability emerged, in both epidemiological and clinical features and in the diagnostic and therapeutic approaches to the disease.
CONCLUSIONS—The clinical approach to SSc, not only in different countries but also in different centres within the same country, is not yet standardised. To overcome this problem, it will be necessary for the scientific community to draw up a standardised procedure for the management of patients with SSc. This would provide a common research tool for different centres engaged in research on this complex disease.

 PMID:11350847

  3. Draft principles, policy, and acceptance criteria for decommissioning of U.S. Department of Energy contaminated surplus facilities and summary of international decommissioning programs

    SciTech Connect

    Singh, B.K. |; Gillette, J.; Jackson, J.

    1994-12-01

    Decommissioning activities enable the DOE to reuse all or part of a facility for future activities and reduce hazards to the general public and any future work force. The DOE Office of Environment, Health and Safety has prepared this document, which consists of decommissioning principles and acceptance criteria, in an attempt to establish a policy that is in agreement with the NRC policy. The purpose of this document is to assist individuals involved with decommissioning activities in determining their specific responsibilities as identified in Draft DOE Order 5820.DDD, ``Decommissioning of US Department of Energy Contaminated Surplus Facilities`` (Appendix A). This document is not intended to provide specific decommissioning methodology. The policies and principles of several international decommissioning programs are also summarized. These programs are from the IAEA, the NRC, and several foreign countries expecting to decommission nuclear facilities. They are included here to demonstrate the different policies that are to be followed throughout the world and to allow the reader to become familiar with the state of the art for environment, safety, and health (ES and H) aspects of nuclear decommissioning.

  4. Using Algal Metrics and Biomass to Evaluate Multiple Ways of Defining Concentration-Based Nutrient Criteria in Streams and their Ecological Relevance

    EPA Science Inventory

    We examined the utility of nutrient criteria derived solely from total phosphorus (TP) concentrations in streams (regression models and percentile distributions) and evaluated their ecological relevance to diatom and algal biomass responses. We used a variety of statistics to cha...

  5. Gender Incongruence of Adolescence and Adulthood: Acceptability and Clinical Utility of the World Health Organization’s Proposed ICD-11 Criteria

    PubMed Central

    Beek, Titia F.; Cohen-Kettenis, Peggy T.; Bouman, Walter P.; de Vries, Annelou L. C.; Steensma, Thomas D.; Witcomb, Gemma L.; Arcelus, Jon; Richards, Christina; Elaut, Els; Kreukels, Baudewijntje P. C.

    2016-01-01

    The World Health Organization (WHO) is currently updating the tenth version of their diagnostic tool, the International Classification of Diseases (ICD, WHO, 1992). Changes have been proposed for the diagnosis of Transsexualism (ICD-10) with regard to terminology, placement and content. The aim of this study was to gather the opinions of transgender individuals (and their relatives/partners) and clinicians in the Netherlands, Flanders (Belgium) and the United Kingdom regarding the proposed changes and the clinical applicability and utility of the ICD-11 criteria of ‘Gender Incongruence of Adolescence and Adulthood’ (GIAA). A total of 628 participants were included in the study: 284 from the Netherlands (45.2%), 8 from Flanders (Belgium) (1.3%), and 336 (53.5%) from the UK. Most participants were transgender people (or their partners/relatives) (n = 522), 89 participants were healthcare providers (HCPs) and 17 were both healthcare providers and (partners/relatives of) transgender people. Participants completed an online survey developed for this study. Most participants were in favor of the proposed diagnostic term of ‘Gender Incongruence’ and thought that this was an improvement on the ICD-10 diagnostic term of ‘Transsexualism’. Placement in a separate chapter dealing with Sexual- and Gender-related Health or as a Z-code was preferred by many and only a small number of participants stated that this diagnosis should be excluded from the ICD-11. In the UK, most transgender participants thought there should be a diagnosis related to being trans. However, if it were to be removed from the chapter on “psychiatric disorders”, many transgender respondents indicated that they would prefer it to be removed from the ICD in its entirety. There were no large differences between the responses of the transgender participants (or their partners and relatives) and HCPs. HCPs were generally positive about the GIAA diagnosis; most thought the diagnosis was clearly

  6. Live Birth and Cumulative Live Birth Rates in Expected Poor Ovarian Responders Defined by the Bologna Criteria Following IVF/ICSI Treatment

    PubMed Central

    Chai, Joyce; Lee, Vivian Chi-Yan; Yeung, Tracy Wing-Yee; Li, Raymond Wun-Hang; Ho, Pak-Chung; Ng, Ernest Hung-Yu

    2015-01-01

    Objective To determine the live birth and cumulative live birth rates of expected poor ovarian responders according to the Bologna criteria and to compare their outcomes with those of expected normal responders Design Retrospective analysis Setting University infertility clinic Patients A total of 1,152 subfertile women undergoing their first in vitro fertilization (IVF) cycle Interventions Women were classified into 4 groups according to the Bologna criteria for comparison Main Outcome Measure(s) Live birth and cumulative live birth rates Results Women with expected poor response (POR) had the lowest live birth rate than the other 3 groups (23.8%, p = 0.031). Cumulative live birth rates were significantly lower in those with expected POR than those with expected normal ovarian response (NOR) (35.8% vs 62.8%, p<0.0001). In the subgroup analysis, the cumulative live birth rates in expected PORs were significantly lower in those who had ≤3 oocytes retrieved (18.6% for ≤3 oocytes vs 44.0% for >3 oocytes, p = 0.006) whereas the live birth rates in fresh cycle did not differ (17.8% vs 30.9%, p = 0.108). Conclusion Women who were expected POR according to the Bologna criteria had lower live birth and cumulative live birth than expected NOR but they still can achieve reasonable treatment outcomes and IVF treatment should not be precluded. PMID:25748478

  7. Prevalence of metabolic syndrome and related factors in bank employees according to different defining criteria, Vitória/ES, Brazil

    PubMed Central

    Salaroli, Luciane Bresciani; Saliba, Renata Aubin Dias; Zandonade, Eliana; Molina, Maria del Carmen Bisi; Bissoli, Nazaré Souza

    2013-01-01

    OBJECTIVE: To determine the prevalence of metabolic syndrome and related factors in bank employees in the city of Vitoria/ES, Brazil. METHODS: This was a cross-sectional study that included 521 working men and women ≥20 years of age. Sociodemographic, lifestyle, anthropometric, biochemical, and hemodynamic characteristics were collected. Metabolic syndrome was diagnosed using the criteria of the National Cholesterol Education Program-ATPIII and the International Diabetes Federation. A logistic regression model was used to calculate the crude and adjusted OR of the variables, and the statistical level of significance was set at 5.0%. RESULTS: We identified 86 (17.2%) and 113 (22.6%) subjects with metabolic syndrome according to the criteria of the National Cholesterol Education Program-ATPIII and the International Diabetes Federation, respectively. The risk of developing metabolic syndrome was higher in individuals with a high school education (OR 2.6 [CI95%, 1.1-6.1]). In overweight and obese subjects, the risks were also higher (OR 12.6 [CI95%, 4.8-33.2, p = 0.000] and OR 43.7% [CI95%, 16.1-118.9, p = 0.000], respectively). CONCLUSION: A large number of bank employees have metabolic syndrome, which can be associated with an increased risk of developing cardiovascular disease. Individuals who had college degrees had a higher prevalence of metabolic syndrome; this finding can be explained by the high rates of overweight and obesity found in subjects with college and graduate school educations. PMID:23420160

  8. Trade-offs in traditional criteria vs environmental acceptability in product development: an example of the drilling fluids industry's response to environmental regulations

    SciTech Connect

    Jones, M.; Collins, C.; Havis, D.

    1980-01-01

    The coevolution of increased energy needs and a heightened environmental awareness within the past decade has been fraught with direct conflicts. Often, these conflicts were necessary to solidify boad policy acts or challenge nebulous or unclear regulations. The drilling fluids industry, a vital part of petroleum exploration and production, has recognized the need for avoiding future conflicts and for insuring the conservation of our environment. This recognition is best witnessed by the production of new products or the alteration of established products to eliminate or minimize environmental impact. As an example, biocides used by the industry to preserve drilling fluids and control microbiological problems have been under close scrutinization by the Environmental Protection Agency, the United States Geological Service, and the National Marine Fisheries Service. The need to develop new products in this area or substitute the active ingredients of established products is evident. Data are presented on 19 active ingredients under consideration by IMCO Services. Of the 19, three failed performance tests. An additional seven were dismissed because of environmental concerns even though all passed performace testing. Of the nine remaining, four were selected because of their optimal combination of performance and environmental acceptability. The final choice appeared acceptable in both categories and was economically competitive. By careful consideration of applicable regulations, it is intended that future conflicts over use and disposal of this product will be minimzed.

  9. Criteria for the development and use of the methodology for environmentally-acceptable fossil energy site evaluation and selection. Volume 2. Final report

    SciTech Connect

    Eckstein, L.; Northrop, G.; Scott, R.

    1980-02-01

    This report serves as a companion document to the report, Volume 1: Environmentally-Acceptable Fossil Energy Site Evaluation and Selection: Methodology and Users Guide, in which a methodology was developed which allows the siting of fossil fuel conversion facilities in areas with the least environmental impact. The methodology, known as SELECS (Site Evaluation for Energy Conversion Systems) does not replace a site specific environmental assessment, or an environmental impact statement (EIS), but does enhance the value of an EIS by thinning down the number of options to a manageable level, by doing this in an objective, open and selective manner, and by providing preliminary assessment and procedures which can be utilized during the research and writing of the actual impact statement.

  10. A New Blind 2D-RAKE Receiver Based on CMA Criteria for Spread Spectrum Systems Suitable for Software Defined Radio Architecture

    NASA Astrophysics Data System (ADS)

    Takayama, Kei; Kamiya, Yukihiro; Fujii, Takeo; Suzuki, Yasuo

    Spread Spectrum (SS) has been widely used for various wireless systems such as cellular systems, wireless local area network (LAN) and so on. Using multiple antennas at the receiver, two-dimensional (2D) RAKE is realized over the time- and the space-domain. However, it should be noted that the 2D-RAKE receiver must detect the bit timing prior to the RAKE combining. In case of deep fading, it is often difficult to detect it due to low signal-to-noise power ratio (SNR). To solve this problem, we propose a new blind 2D-RAKE receiver based on the constant modulus algorithm (CMA). Since it does not need a priori bit timing detection, it is possible to compensate frequency selective fading even in very low SNR environments. The proposed method is particularly suitable for the software defined radio (SDR) architecture. The performance of the proposed method is investigated through computer simulations.

  11. Standard format and content acceptance criteria for the Material Control and Accounting (MC and A) Reform Amendment: 10 CFR Part 74, Subpart E. Revision 1

    SciTech Connect

    1995-04-01

    In 1987 the NRC revised the material control and accounting requirements for NRC licensees authorized to possess and use a formula quantity (i.e., 5 formula kilograms or more) of strategic special nuclear material. Those revisions issued as 10 CFR 74.51-59 require timely monitoring of in-process inventory and discrete items to detect anomalies potentially indicative of material losses. Timely detection and enhanced loss localization capabilities are beneficial to alarm resolution and also for material recovery in the event of an actual loss. NUREG-1280 was issued in 1987 to present criteria that could be used by applicants, licensees, and NRC license reviewers in the initial preparation and subsequent review of fundamental nuclear material control (FNMC) plans submitted in response to the Reform Amendment. This document is also intended for both licensees and license reviewers with respect to FNMC plan revisions. General performance objectives, system capabilities, process monitoring, item monitoring, alarm resolution, quality assurance, and accounting are addressed. This revision to NUREG-1280 is an expansion of the initial edition, which clarifies and expands upon several topics and addresses issues identified under Reform Amendment implementation experience.

  12. Update on donor assessment, resuscitation, and acceptance criteria, including novel techniques--non-heart-beating donor lung retrieval and ex vivo donor lung perfusion.

    PubMed

    Yeung, Jonathan C; Cypel, Marcelo; Waddell, Thomas K; van Raemdonck, Dirk; Keshavjee, Shaf

    2009-05-01

    The shortage of adequate organ donors remains a great challenge in clinical lung transplantation. With increasing experience in the medical management and surgical technique of lung transplantation, gradual expansion of the criteria for lung donor selection has occurred with beneficial effects on the donor pool. Interest in donation after cardiac death also is increasing as the gap increases between donors and the needs of listed patients. Successful use of these new sources of lungs depends on the accurate assessment and prediction of transplanted lung function. Promising techniques for lung assessment and diagnostics include investigating key genes associated with graft failure or good graft performance using molecular approaches, and ex vivo evaluation. Further studies are needed to answer remaining questions about the best technique and solution to reperfuse human lungs for several hours without edema formation. As the predictive ability to discern good from injured donor lungs improves, strategies to repair donor lungs become increasingly important. Prolonged normothermic EVLP seems to be a platform on which many reparative strategies can be realized. With these new methods for assessing and resuscitating lungs accurately, it is hoped that inroads will be made toward providing every listed patient a chance for successful lung transplantation. PMID:19662970

  13. Perspective: Towards environmentally acceptable criteria for downstream fish passage through mini hydro and irrigation infrastructure in the Lower Mekong River Basin

    SciTech Connect

    Baumgartner, Lee J.; Deng, Zhiqun; Thorncraft, Garry; Boys, Craig A.; Brown, Richard S.; Singhanouvong, Douangkham; Phonekhampeng, Oudom

    2014-02-26

    Tropical rivers have high annual discharges optimal for hydropower and irrigation development. The Mekong River is one of the largest tropical river systems, supporting a unique mega-diverse fish community. Fish are an important commodity in the Mekong, contributing a large proportion of calcium, protein, and essential nutrients to the diet of the local people and providing a critical source of income for rural households. Many of these fish migrate not only upstream and downstream within main-channel habitats but also laterally into highly productive floodplain habitat to both feed and spawn. Most work to date has focused on providing for upstream fish passage, but downstream movement is an equally important process to protect. Expansion of hydropower and irrigation weirs can disrupt downstream migrations and it is important to ensure that passage through regulators or mini hydro systems is not harmful or fatal. Many new infrastructure projects (<6 m head) are proposed for the thousands of tributary streams throughout the Lower Mekong Basin and it is important that designs incorporate the best available science to protect downstream migrants. Recent advances in technology have provided new techniques which could be applied to Mekong fish species to obtain design criteria that can facilitate safe downstream passage. Obtaining and applying this knowledge to new infrastructure projects is essential in order to produce outcomes that are more favorable to local ecosystems and fisheries.

  14. Paleontological evidence for defining the Anthropocene

    NASA Astrophysics Data System (ADS)

    Barnosky, A. D.

    2012-12-01

    Paleontological criteria formed the basis for defining most of the geological eras, periods, epochs, and ages that are commonly recognized. By the same token, the Anthropocene can be defined by paleontological distinctiveness in accordance with commonly accepted biostratigraphic and biochronologic practice. Here I focus on the utility of defining the Anthropocene by the distinctive fossils (or potential fossils of the future) that have accumulated and are accumulating in the sedimentary record. I discuss what kinds of biostratrigraphic criteria would be of most use in recognizing the Anthropocene's base and temporal extent, including pros and cons of definitions based on range zones, interval zones, lineage zones, assemblage zones, and abundance zones, as well as implications for potential reference sections. Key paleontological criteria useful in formally defining the Anthropocene as a geological epoch include (1) anthropogenic trace fossils such as buildings, roads, plastics, etc; (2) abundance zones based on remains of domesticated species and humans; and (3) assemblage zones based on species transported around the globe by people. The magnitude of paleontologically-recognizable changes that have occurred since humans became the dominant species on Earth is at least as great as the paleontological differences that distinguish other Cenozoic epochs, and supports recognition of the Anthropocene as a formal stratigraphic unit.

  15. Validation and acceptance of synthetic infrared imagery

    NASA Astrophysics Data System (ADS)

    Smith, Moira I.; Bernhardt, Mark; Angell, Christopher R.; Hickman, Duncan; Whitehead, Philip; Patel, Dilip

    2004-08-01

    This paper describes the use of an image query database (IQ-DB) tool as a means of implementing a validation strategy for synthetic long-wave infrared images of sea clutter. Specifically it was required to determine the validity of the synthetic imagery for use in developing and testing automatic target detection algorithms. The strategy adopted for exploiting synthetic imagery is outlined and the key issues of validation and acceptance are discussed in detail. A wide range of image metrics has been developed to achieve pre-defined validation criteria. A number of these metrics, which include post processing algorithms, are presented. Furthermore, the IQ-DB provides a robust mechanism for configuration management and control of the large volume of data used. The implementation of the IQ-DB is reviewed in terms of its cardinal point specification and its central role in synthetic imagery validation and EOSS progressive acceptance.

  16. Criteria for Developing Criteria Sets.

    ERIC Educational Resources Information Center

    Martin, James L.

    Criteria sets are a necessary step in the systematic development of evaluation in education. Evaluation results from the combination of criteria and evidence. There is a need to develop explicit tools for evaluating criteria, similar to those used in evaluating evidence. The formulation of such criteria depends on distinguishing between terms…

  17. Regulatory applications of sediment criteria. Final report

    SciTech Connect

    Not Available

    1987-06-23

    The report briefly describes the development of sediment criteria, discusses their utility and appropriate regulatory applications, and recommends steps to enhance the acceptance of sediment criteria by the regulatory and regulated communities.

  18. Acceptance test procedure for High Pressure Water Jet System

    SciTech Connect

    Crystal, J.B.

    1995-05-30

    The overall objective of the acceptance test is to demonstrate a combined system. This includes associated tools and equipment necessary to perform cleaning in the 105 K East Basin (KE) for achieving optimum reduction in the level of contamination/dose rate on canisters prior to removal from the KE Basin and subsequent packaging for disposal. Acceptance tests shall include necessary hardware to achieve acceptance of the cleaning phase of canisters. This acceptance test procedure will define the acceptance testing criteria of the high pressure water jet cleaning fixture. The focus of this procedure will be to provide guidelines and instructions to control, evaluate and document the acceptance testing for cleaning effectiveness and method(s) of removing the contaminated surface layer from the canister presently identified in KE Basin. Additionally, the desired result of the acceptance test will be to deliver to K Basins a thoroughly tested and proven system for underwater decontamination and dose reduction. This report discusses the acceptance test procedure for the High Pressure Water Jet.

  19. Performance Criteria: Concrete, Volume 1.

    ERIC Educational Resources Information Center

    Hallenbeck, Roger F.; And Others

    The State University Construction Fund provides guidance and direction to professionals participating in its program by issuing performance criteria that set forth owner or user requirements. This document provides guidelines in the form of performance criteria, testing procedures, and instructions to achieve an acceptable level of performance in…

  20. Defining "Development".

    PubMed

    Pradeu, Thomas; Laplane, Lucie; Prévot, Karine; Hoquet, Thierry; Reynaud, Valentine; Fusco, Giuseppe; Minelli, Alessandro; Orgogozo, Virginie; Vervoort, Michel

    2016-01-01

    Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined biological, philosophical, and historical approach, we ask whether it is possible and useful to define biological development, and, if such a definition is indeed possible and useful, which definition(s) can be considered as the most satisfactory.

  1. Defining Infertility

    MedlinePlus

    ... of the American Society for Reproductive Medicine Defining infertility What is infertility? Infertility is “the inability to conceive after 12 months ... to conceive after 6 months is generally considered infertility. How common is it? Infertility affects 10%-15% ...

  2. Defining cure.

    PubMed

    Hilton, Paul; Robinson, Dudley

    2011-06-01

    This paper is a summary of the presentations made as Proposal 2-"Defining cure" to the 2nd Annual meeting of the ICI-Research Society, in Bristol, 16th June 2010. It reviews definitions of 'cure' and 'outcome', and considers the impact that varying definition may have on prevalence studies and cure rates. The difference between subjective and objective outcomes is considered, and the significance that these different outcomes may have for different stakeholders (e.g. clinicians, patients, carers, industry etc.) is discussed. The development of patient reported outcome measures and patient defined goals is reviewed, and consideration given to the use of composite end-points. A series of proposals are made by authors and discussants as to how currently validated outcomes should be applied, and where our future research activity in this area might be directed.

  3. Defining biobank.

    PubMed

    Hewitt, Robert; Watson, Peter

    2013-10-01

    The term "biobank" first appeared in the scientific literature in 1996 and for the next five years was used mainly to describe human population-based biobanks. In recent years, the term has been used in a more general sense and there are currently many different definitions to be found in reports, guidelines and regulatory documents. Some definitions are general, including all types of biological sample collection facilities. Others are specific and limited to collections of human samples, sometimes just to population-based collections. In order to help resolve the confusion on this matter, we conducted a survey of the opinions of people involved in managing sample collections of all types. This survey was conducted using an online questionnaire that attracted 303 responses. The results show that there is consensus that the term biobank may be applied to biological collections of human, animal, plant or microbial samples; and that the term biobank should only be applied to sample collections with associated sample data, and to collections that are managed according to professional standards. There was no consensus on whether a collection's purpose, size or level of access should determine whether it is called a biobank. Putting these findings into perspective, we argue that a general, broad definition of biobank is here to stay, and that attention should now focus on the need for a universally-accepted, systematic classification of the different biobank types. PMID:24835262

  4. Revisiting Bioaccumulation Criteria

    EPA Science Inventory

    The objective of workgroup 5 was to revisit the B(ioaccumulation) criteria that are currently being used to identify POPs under the Stockholm Convention and PBTs under CEPA, TSCA, REACh and other programs. Despite the lack of a recognized definition for a B substance, we defined ...

  5. IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

    PubMed

    MacGregor, James T; Frötschl, Roland; White, Paul A; Crump, Kenny S; Eastmond, David A; Fukushima, Shoji; Guérard, Melanie; Hayashi, Makoto; Soeteman-Hernández, Lya G; Johnson, George E; Kasamatsu, Toshio; Levy, Dan D; Morita, Takeshi; Müller, Lutz; Schoeny, Rita; Schuler, Maik J; Thybaud, Véronique

    2015-05-01

    This is the second of two reports from the International Workshops on Genotoxicity Testing (IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (the QWG). The first report summarized the discussions and recommendations of the QWG related to the need for quantitative dose-response analysis of genetic toxicology data, the existence and appropriate evaluation of threshold responses, and methods to analyze exposure-response relationships and derive points of departure (PoDs) from which acceptable exposure levels could be determined. This report summarizes the QWG discussions and recommendations regarding appropriate approaches to evaluate exposure-related risks of genotoxic damage, including extrapolation below identified PoDs and across test systems and species. Recommendations include the selection of appropriate genetic endpoints and target tissues, uncertainty factors and extrapolation methods to be considered, the importance and use of information on mode of action, toxicokinetics, metabolism, and exposure biomarkers when using quantitative exposure-response data to determine acceptable exposure levels in human populations or to assess the risk associated with known or anticipated exposures. The empirical relationship between genetic damage (mutation and chromosomal aberration) and cancer in animal models was also examined. It was concluded that there is a general correlation between cancer induction and mutagenic and/or clastogenic damage for agents thought to act via a genotoxic mechanism, but that the correlation is limited due to an inadequate number of cases in which mutation and cancer can be compared at a sufficient number of doses in the same target tissues of the same species and strain exposed under directly comparable routes and experimental protocols.

  6. Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome

    PubMed Central

    Dhiman, Radha K; Agrawal, Swastik; Gupta, Tarana; Duseja, Ajay; Chawla, Yogesh

    2014-01-01

    AIM: To compare the utility of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) and Asia-Pacific Association for the Study of Liver (APASL) definitions of acute-on-chronic liver failure (ACLF) in predicting short-term prognosis of patients with ACLF. METHODS: Consecutive patients of cirrhosis with acute decompensation were prospectively included. They were grouped into ACLF and no ACLF groups as per CLIF-SOFA and APASL criteria. Patients were followed up for 3 mo from inclusion or mortality whichever was earlier. Mortality at 28-d and 90-d was compared between no ACLF and ACLF groups as per both criteria. Mortality was also compared between different grades of ACLF as per CLIF-SOFA criteria. Prognostic scores like CLIF-SOFA, Acute Physiology and Chronic Health Evaluation (APACHE)-II, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores were evaluated for their ability to predict 28-d mortality using area under receiver operating curves (AUROC). RESULTS: Of 50 patients, 38 had ACLF as per CLIF-SOFA and 19 as per APASL criteria. Males (86%) were predominant, alcoholic liver disease (68%) was the most common etiology of cirrhosis, sepsis (66%) was the most common cause of acute decompensation while infection (66%) was the most common precipitant of acute decompensation. The 28-d mortality in no ACLF and ACLF groups was 8.3% and 47.4% (P = 0.018) as per CLIF-SOFA and 39% and 37% (P = 0.895) as per APASL criteria. The 28-d mortality in patients with no ACLF (n = 12), ACLF grade 1 (n = 11), ACLF grade 2 (n = 14) and ACLF grade 3 (n = 13) as per CLIF-SOFA criteria was 8.3%, 18.2%, 42.9% and 76.9% (χ2 for trend, P = 0.002) and 90-d mortality was 16.7%, 27.3%, 78.6% and 100% (χ2 for trend, P < 0.0001) respectively. Patients with prior decompensation had similar 28-d and 90-d mortality (39.3% and 53.6%) as patients without prior decompensation (36.4% and 63.6%) (P = NS). AUROCs for 28-d mortality were 0.795, 0.787, 0.739 and 0.710 for

  7. Defining chaos

    SciTech Connect

    Hunt, Brian R.; Ott, Edward

    2015-09-15

    In this paper, we propose, discuss, and illustrate a computationally feasible definition of chaos which can be applied very generally to situations that are commonly encountered, including attractors, repellers, and non-periodically forced systems. This definition is based on an entropy-like quantity, which we call “expansion entropy,” and we define chaos as occurring when this quantity is positive. We relate and compare expansion entropy to the well-known concept of topological entropy to which it is equivalent under appropriate conditions. We also present example illustrations, discuss computational implementations, and point out issues arising from attempts at giving definitions of chaos that are not entropy-based.

  8. Monitoring Reading Behavior: Criteria for Performance.

    ERIC Educational Resources Information Center

    Powell, William R.

    Effective use of the informal reading inventory (IRI) depends upon the criteria used in determining the functional reading levels and more specifically the word recognition criteria employed in describing acceptable limits of oral reading behavior. The author of this paper looks at the diverse sets of criteria commonly used, the problems…

  9. A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial).

    PubMed

    Mead, Graham M; Barrans, Sharon L; Qian, Wendi; Walewski, Jan; Radford, John A; Wolf, Max; Clawson, Simon M; Stenning, Sally P; Yule, Claire L; Jack, Andrew S

    2008-09-15

    This prospective study aimed to develop reproducible diagnostic criteria for sporadic Burkitt lymphoma (BL), applicable to routine practice, and to evaluate the efficacy of dose-modified (dm) CODOX-M/IVAC in patients diagnosed using these criteria. The study was open to patients with an aggressive B-cell lymphoma with an MKI67 fraction approaching 100%. Immunophenotype and fluorescent in situ hybridization (FISH) were used to separate BL from other aggressive B-cell lymphomas. BL was characterized by the presence of a cMYC rearrangement as a sole cytogenetic abnormality occurring in patients with a germinal center phenotype with absence of BCL-2 expression and abnormal TP53 expression. A total of 128 patients were eligible for the study, of whom 58 were considered to have BL and 70 to have diffuse large B-cell lymphoma (DLBCL). There were 110 clinically fit patients who received dmCODOX-M (methotrexate, dose 3 g/m(2)) with or without IVAC according to risk group. The 2-year progression-free survival was 64% (95% confidence interval [CI] 51%-77%) for BL, 55% (95% CI 42%-66%) for DLBCL, 85% (95% CI 73%-97%) for low risk, and 49% (95% CI 38%-60%) for high-risk patients. The observed differences in outcome and other clinical features validate the proposed diagnostic criteria. Compared with the previous trial LY06 with full-dose methotrexate (6.7 g/m(2)), there was a reduction in toxicity with comparable outcomes. This study was registered at www.clinicaltrials.gov as NCT00040690.

  10. Increasing dental hygiene student diversity: life-performance questions as alternative admissions criteria.

    PubMed

    Helm, Denise Muesch; Grabarek, Ellen S; Reveal, Marjorie

    2003-01-01

    The goal of this study was to create a race/ethnic-neutral admission process. An increase in student diversity in the Northern Arizona University Dental Hygiene Program (NAU DH) was accomplished through modification of its acceptance process. Sixty students, 22% underrepresented minority (URM), were selected using alternative criteria compared with 6.7% URM that would have been accepted using traditional criteria. For the purpose of this study, URM are defined as African American, Hispanic, Native American, or bicultural, groups that are underrepresented in dental hygiene. Six life-performance questions were added on the written application and were designed to assess the candidates' personal characteristics, including (1) leadership, (2) community service, (3) realistic self-appraisal, (4) personal support system, (5) ability to deal with racism, (6) ability to set goals and self-responsibility. Scores from the response to these questions were used as part of the total selection criteria. Data analysis revealed that white candidates scored higher than URM candidates on grade point average (GPA), science GPA, and total points, yet both groups scored the same on life-performance questions. On the basis of these findings, we conclude that alternative criteria in the acceptance process more fairly assesses candidates' qualifications and increases the diversity of the NAU DH student population. These alternative acceptance criteria may serve as a model for dental hygiene and other allied health programs.

  11. Recommended new criteria for the selection of nuclear waste repository sites in Columbia River basalt and US Gulf Coast domed salt

    SciTech Connect

    Steinborn, T.L.; Wagoner, J.L.; Qualheim, B.; Fitts, C.R.; Stetkar, R.E.; Turnbull, R.W.

    1980-06-16

    Screening criteria and specifications are recommended to aid in the evaluation of sites proposed for nuclear waste disposal in basalt and domed salt. The recommended new criteria proposed in this report are intended to supplement existing repository-related criteria for nuclear waste disposal. The existing criteria are contained in 10 CFR 60 sections which define siting criteria of the Nuclear Regulatory Commission (NRC), and ONWI 33(2) which defines siting criteria of the Office of Nuclear Waste Isolation (ONWI) for the Department of Energy. The specifications are conditions or parameter values that the authors recommend be applied in site acceptance evaluations. The siting concerns covered in this report include repository depth, host rock extent, seismic setting, structural and tectonic conditions, groundwater and rock geochemistry, volcanism, surface and subsurface hydrology, and socioeconomic issues, such as natural resources, land use, and population distribution.

  12. Screening for Intermediately Vancomycin-Susceptible and Vancomycin-Heteroresistant Staphylococcus aureus by Use of Vancomycin-Supplemented Brain Heart Infusion Agar Biplates: Defining Growth Interpretation Criteria Based on Gold Standard Confirmation.

    PubMed

    Khatib, Riad; Riederer, Kathleen; Sharma, Mamta; Shemes, Stephen; Iyer, Sugantha P; Szpunar, Susan

    2015-11-01

    BHI agars supplemented with vancomycin 4 (BHI-V4) and 3 (BHI-V3) mg/liter have been proposed for screening vancomycin intermediately susceptible Staphylococcus aureus (VISA) and heteroresistant (hVISA) phenotypes, respectively, but growth interpretation criteria have not been established. We reviewed the growth results (CFU) during population analysis profile-area under the curve (PAP-AUC) of consecutive methicillin-resistant Staphylococcus aureus (MRSA) blood isolates, which were saved intermittently between 1996 and 2012. CFU counts on BHI-V4 and BHI-V3 plates were stratified according to PAP-AUC interpretive criteria: <0.90 (susceptible [S-MRSA]), 0.90 to 1.3 (hVISA), and >1.3 (VISA). CFU cutoffs that best predict VISA and hVISA were determined with the use of receiver operating characteristic (ROC) curves. Mu3, Mu50, and methicillin-susceptible S. aureus (MSSA) controls were included. We also prospectively evaluated manufacturer-made BHI-V3/BHI-V4 biplates for screening of 2010-2012 isolates. The PAP-AUC of 616 clinical samples was consistent with S-MRSA, hVISA, and VISA in 550 (89.3%), 48 (7.8%), and 18 (2.9%) instances, respectively. For VISA screening on BHI-V4, a cutoff of 2 CFU/droplet provided 100% sensitivity and 97.7% specificity. To distinguish VISA from hVISA, a cutoff of 16 CFU provided 83.3% sensitivity and 94.7% specificity; the specificity was lowered to 89.5% with a 12-CFU cutoff. For detecting hVISA/VISA on BHI-V3, a 2-CFU/droplet cutoff provided 98.5% sensitivity and 93.8% specificity. These results suggest that 2-CFU/droplet cutoffs on BHI-V4 and BHI-V3 best approximate VISA and hVISA gold standard confirmation, respectively, with minimal overlap in samples with borderline PAP-AUC. Simultaneous screening for VISA/hVISA on manufacturer-made BHI-V4/BHI-V3 biplates is easy to standardize and may reduce the requirement for PAP-AUC confirmation. PMID:26311860

  13. Screening for Intermediately Vancomycin-Susceptible and Vancomycin-Heteroresistant Staphylococcus aureus by Use of Vancomycin-Supplemented Brain Heart Infusion Agar Biplates: Defining Growth Interpretation Criteria Based on Gold Standard Confirmation.

    PubMed

    Khatib, Riad; Riederer, Kathleen; Sharma, Mamta; Shemes, Stephen; Iyer, Sugantha P; Szpunar, Susan

    2015-11-01

    BHI agars supplemented with vancomycin 4 (BHI-V4) and 3 (BHI-V3) mg/liter have been proposed for screening vancomycin intermediately susceptible Staphylococcus aureus (VISA) and heteroresistant (hVISA) phenotypes, respectively, but growth interpretation criteria have not been established. We reviewed the growth results (CFU) during population analysis profile-area under the curve (PAP-AUC) of consecutive methicillin-resistant Staphylococcus aureus (MRSA) blood isolates, which were saved intermittently between 1996 and 2012. CFU counts on BHI-V4 and BHI-V3 plates were stratified according to PAP-AUC interpretive criteria: <0.90 (susceptible [S-MRSA]), 0.90 to 1.3 (hVISA), and >1.3 (VISA). CFU cutoffs that best predict VISA and hVISA were determined with the use of receiver operating characteristic (ROC) curves. Mu3, Mu50, and methicillin-susceptible S. aureus (MSSA) controls were included. We also prospectively evaluated manufacturer-made BHI-V3/BHI-V4 biplates for screening of 2010-2012 isolates. The PAP-AUC of 616 clinical samples was consistent with S-MRSA, hVISA, and VISA in 550 (89.3%), 48 (7.8%), and 18 (2.9%) instances, respectively. For VISA screening on BHI-V4, a cutoff of 2 CFU/droplet provided 100% sensitivity and 97.7% specificity. To distinguish VISA from hVISA, a cutoff of 16 CFU provided 83.3% sensitivity and 94.7% specificity; the specificity was lowered to 89.5% with a 12-CFU cutoff. For detecting hVISA/VISA on BHI-V3, a 2-CFU/droplet cutoff provided 98.5% sensitivity and 93.8% specificity. These results suggest that 2-CFU/droplet cutoffs on BHI-V4 and BHI-V3 best approximate VISA and hVISA gold standard confirmation, respectively, with minimal overlap in samples with borderline PAP-AUC. Simultaneous screening for VISA/hVISA on manufacturer-made BHI-V4/BHI-V3 biplates is easy to standardize and may reduce the requirement for PAP-AUC confirmation.

  14. Early Site Permit Demonstration Program: Regulatory criteria evaluation report

    SciTech Connect

    Not Available

    1993-03-01

    The primary objective of the ESPDP is to demonstrate successfully the use of 10CFR52 to obtain ESPs for one or more US sites for one (or more) ALWR nuclear power plants. It is anticipated that preparation of the ESP application and interaction with NRC during the application review process will result not only in an ESP for the applicant(s) but also in the development of criteria and definition of processes, setting the precedent that facilitates ESPs for subsequent ESP applications. Because siting regulatory processes and acceptance criteria are contained in over 100 separate documents, comprehensive licensing and technical reviews were performed to establish whether the requirements and documentation are self-consistent, whether the acceptance criteria are sufficiently well-defined and clear, and whether the licensing process leading to the issuance of an ESP is unambiguously specified. The results of the technical and licensing evaluations are presented in this report. The purpose, background, and organization of the ESPDP is delineated in Section 1. Section 11 contains flowcharts defining siting application requirements, environmental report requirements, and emergency planning/preparedness requirements for ALWRS. The licensing and technical review results are presented in Section III.

  15. Crew Transportation Technical Standards and Design Evaluation Criteria

    NASA Technical Reports Server (NTRS)

    Lueders, Kathryn L.; Thomas, Rayelle E. (Compiler)

    2015-01-01

    Crew Transportation Technical Standards and Design Evaluation Criteria contains descriptions of technical, safety, and crew health medical processes and specifications, and the criteria which will be used to evaluate the acceptability of the Commercial Providers' proposed processes and specifications.

  16. Development of location criteria for criticality alarm detector placements

    SciTech Connect

    Miles, R.E.

    1992-07-01

    This document describes the development of methodology used at the Rocky Flats Plant (RFP) for locating thermal neutron sensitive criticality alarm detectors. It also presents the resulting locations criteria. This work was designed to demonstrate compliance with applicable American National Standards (ANSI) and Department of Energy (DOE) order requirements for immediate detection of the minimum accident of concern. The development of the location criteria makes use of three generic models of the minimum accident of concern as defined in ANSI/American Nuclear Society (ANS) 8.3-1986. Calculations are used to compute flux values as a function of distance from these three generic models. Acceptable detector location positions are defined as those in which the calculated thermal flux equals or exceeds the measured thermal flux sensitivity of the detector. Using this methodology, conservative location criteria were developed for use in placing criticality alarm detectors in the various buildings at RFP. Proper use of these location criteria will ensure immediate detection of any credible criticality in accord with the requirements of DOE Order 5480.5 and ANSI/ANS 8.3-1986.

  17. Defining clinical 'workstation'.

    PubMed

    Safran, C

    1994-01-01

    Interest in the physician's workstation has increased, yet often seems to focus on technological issues. At Boston's Beth Israel Hospital, the Center for Clinical Computing includes heavily used clinical workstations. Their evolution over the past 20 years suggests design criteria: the workstation must be patient-centered, the interface must be uniform, and data acquisition must be addressed at a system level. However, it is clinical function that really defines a workstation. The workstation should do the following: display patient information rapidly and flexibly; assist with administrative tasks; facilitate communication; and provide four important types of decision support: access to literature, access to databases, clinical calculation, and 'synthetic vision,' or different views of patient data. The solutions to our healthcare problems are not in 'workboxes' we can buy, but in creative approaches we can imagine. We need a patient-centered infrastructure and a reduced workload for the clinician-perhaps a 'worklesstation'. PMID:8125637

  18. Content validity of the DSM-IV borderline and narcissistic personality disorder criteria sets.

    PubMed

    Blais, M A; Hilsenroth, M J; Castlebury, F D

    1997-01-01

    This study sought to empirically evaluate the content validity of the newly revised DSM-IV narcissistic personality disorder (NPD) and borderline personality disorder (BPD) criteria sets. Using the essential features of each disorder as construct definitions, factor analysis was used to determine how adequately the criteria sets covered the constructs. In addition, this empirical investigation sought to: 1) help define the dimensions underlying these polythetic disorders; 2) identify core features of each diagnosis; and 3) highlight the characteristics that may be most useful in diagnosing these two disorders. Ninety-one outpatients meeting DSM-IV criteria for a personality disorder (PD) were identified through a retrospective analysis of chart information. Records of these 91 patients were independently rated on all of the BPD and NPD symptom criteria for the DSM-IV. Acceptable interrater reliability (kappa estimates) was obtained for both presence or absence of a PD and symptom criteria for BPD and NPD. The factor analysis, performed separately for each disorder, identified a three-factor solution for both the DSM-IV BPD and NPD criteria sets. The results of this study provide strong support for the content validity of the NPD criteria set and moderate support for the content validly of the BPD criteria set. Three domains were found to comprise the BPD criteria set, with the essential features of interpersonal and identity instability forming one domain, and impulsivity and affective instability each identified as separate domains. Factor analysis of the NPD criteria set found three factors basically corresponding to the essential features of grandiosity, lack of empathy, and need for admiration. Therefore, the NPD criteria set adequately covers the essential or defining features of the disorder.

  19. Criteria for cesium capsules to be shipped as special form radioactive material

    SciTech Connect

    Lundeen, J.E.

    1994-10-01

    The purpose of this report is to compile all the documentation which defines the criteria for Waste Encapsulation and Storage Facility (WESF) cesium capsules at the IOTECH facility and Applied Radiant Energy Corporation (ARECO) to be shipped as special form radioactive material in the Beneficial Uses Shipping System (BUSS) Cask. The capsules were originally approved as special form in 1975, but in 1988 the integrity of the capsules came into question. WHC developed the Pre-shipment Acceptance Test Criteria for capsules to meet in order to be shipped as special form material. The Department of Energy approved the criteria and directed WHC to ship the capsules at IOTECH and ARECO meeting this criteria to WHC as special form material.

  20. Design criteria for maglev structures

    SciTech Connect

    Sandberg, H.R.; Williams, J.R.

    1997-05-01

    Maglev systems represent an entirely new concept in transportation. They will not operate on nor share the right-of-way with any other system. It is important, therefore, that the guideways be designed and constructed so as to be economical, constructable, durable, adaptable, reliable, and readily maintained. Comparisons should be made with the current transportation systems, especially highways and railroads. Since most of the guideway will be elevated, the comparison should be with the bridges. The object of the comparisons should be to avoid the shortcomings of the other systems while building on their strengths. This paper develops in some detail design and construction criteria that will ensure a good, long-lived performance of the maglev guideway. The importance of beauty should have a low priority in comparison to the other design criteria. Clean, simple details meeting other criteria will ensure an acceptable appearance. These criteria were used in evaluating the four maglev concepts developed for the National Maglev Initiative.

  1. Correctness criteria for process migration

    NASA Technical Reports Server (NTRS)

    Lu, Chin; Liu, J. W. S.

    1987-01-01

    Two correctness criteria, the state consistency criterion and the property consistency criterion for process migration are discussed. The state machine approach is used to model the interactions between a user process and its environment. These criteria are defined in terms of the model. The idea of environment view was introduced to distinguish what a user process observes about its environment from what its environment state really is and argue that a consistent view of the environment must be maintained for every migrating process.

  2. Establishing endangered species recovery criteria using predictive simulation modeling

    USGS Publications Warehouse

    McGowan, Conor P.; Catlin, Daniel H.; Shaffer, Terry L.; Gratto-Trevor, Cheri L.; Aron, Carol

    2014-01-01

    Listing a species under the Endangered Species Act (ESA) and developing a recovery plan requires U.S. Fish and Wildlife Service to establish specific and measurable criteria for delisting. Generally, species are listed because they face (or are perceived to face) elevated risk of extinction due to issues such as habitat loss, invasive species, or other factors. Recovery plans identify recovery criteria that reduce extinction risk to an acceptable level. It logically follows that the recovery criteria, the defined conditions for removing a species from ESA protections, need to be closely related to extinction risk. Extinction probability is a population parameter estimated with a model that uses current demographic information to project the population into the future over a number of replicates, calculating the proportion of replicated populations that go extinct. We simulated extinction probabilities of piping plovers in the Great Plains and estimated the relationship between extinction probability and various demographic parameters. We tested the fit of regression models linking initial abundance, productivity, or population growth rate to extinction risk, and then, using the regression parameter estimates, determined the conditions required to reduce extinction probability to some pre-defined acceptable threshold. Binomial regression models with mean population growth rate and the natural log of initial abundance were the best predictors of extinction probability 50 years into the future. For example, based on our regression models, an initial abundance of approximately 2400 females with an expected mean population growth rate of 1.0 will limit extinction risk for piping plovers in the Great Plains to less than 0.048. Our method provides a straightforward way of developing specific and measurable recovery criteria linked directly to the core issue of extinction risk. Published by Elsevier Ltd.

  3. Photovoltaic system criteria documents. Volume 6: Criteria for auditing photovoltaic system applications and experiments. Revision A

    NASA Astrophysics Data System (ADS)

    Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

    1980-09-01

    The criteria is defined for auditing photovoltaic system applications and experiments. The purpose of the audit is twofold: to see if the application is meeting its stated objectives and to measure the application's progress in terms of the National Photovoltaic Program's goals of performance, cost, reliability, safety, and socio-environmental acceptance. The information obtained from an audit will be used to assess the status of an application and to provide the Department of Energy with recommendations on the future conduct of the application. Those aspects are covered of a site audit necessary to produce a systematic method for the gathering of qualitative and quantitative data to measure the success of an application. A sequence of audit events and guidelines for obtaining the required information is presented.

  4. Photovoltaic system criteria documents. Volume 6: Criteria for auditing photovoltaic system applications and experiments. Revision A

    NASA Technical Reports Server (NTRS)

    Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

    1980-01-01

    The criteria is defined for auditing photovoltaic system applications and experiments. The purpose of the audit is twofold: to see if the application is meeting its stated objectives and to measure the application's progress in terms of the National Photovoltaic Program's goals of performance, cost, reliability, safety, and socio-environmental acceptance. The information obtained from an audit will be used to assess the status of an application and to provide the Department of Energy with recommendations on the future conduct of the application. Those aspects are covered of a site audit necessary to produce a systematic method for the gathering of qualitative and quantitative data to measure the success of an application. A sequence of audit events and guidelines for obtaining the required information is presented.

  5. Curing myeloma at last: defining criteria and providing the evidence

    PubMed Central

    Mitchell, Alan; van Rhee, Frits; Epstein, Joshua; Morgan, Gareth J.; Crowley, John

    2014-01-01

    Does the dogma that multiple myeloma is incurable still hold?. The genomic chaos and resulting resistance to apoptosis of myeloma, long considered an obstacle to cure, formed the basis of Total Therapy (TT) program. The TT approach uses all myeloma-active drugs upfront to target drug-resistant subclones during initial treatment to prevent later relapse. Long-term follow-up of 1202 patients (TT1: n = 231, median follow-up: 21 years; TT2: 668, median follow-up: 12 years; TT3a: n = 303, median follow-up: 9 years) permitted investigation of whether progression-free survival (PFS) and complete response (CR) duration were consistent with curability, ie observation of plateaus in Kaplan-Meier plots for PFS and CR duration. In the subset of 627 patients with plasma cell gene expression profiling data, cure plateaus were apparent at 5 years in the 14% with high-risk myeloma compared with 10 years in the remainder with low-risk disease. A parametric model based on PFS and CR duration supported an increase in curability: 10-year PFS and CR estimates increased from 8.8%/17.9% in TT1 to 15.5%/28.2% in TT2’s control arm to 25.1%/35.6% in TT2’s thalidomide arm and to 32.9%/48.8% in TT3a. Toward developing novel therapies, we recommend a concerted focus on patients with high-risk myeloma whose outcome has not been advanced. PMID:25293776

  6. Defining the Anthropocene

    NASA Astrophysics Data System (ADS)

    Lewis, Simon; Maslin, Mark

    2016-04-01

    Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Should the Anthropocene - the idea that human activity is a force acting upon the Earth system in ways that mean that Earth will be altered for millions of years - be defined as a geological time-unit at the level of an Epoch? Here we appraise the data to assess such claims, first in terms of changes to the Earth system, with particular focus on very long-lived impacts, as Epochs typically last millions of years. Can Earth really be said to be in transition from one state to another? Secondly, we then consider the formal criteria used to define geological time-units and move forward through time examining whether currently available evidence passes typical geological time-unit evidence thresholds. We suggest two time periods likely fit the criteria (1) the aftermath of the interlinking of the Old and New Worlds, which moved species across continents and ocean basins worldwide, a geologically unprecedented and permanent change, which is also the globally synchronous coolest part of the Little Ice Age (in Earth system terms), and the beginning of global trade and a new socio-economic "world system" (in historical terms), marked as a golden spike by a temporary drop in atmospheric CO2, centred on 1610 CE; and (2) the aftermath of the Second World War, when many global environmental changes accelerated and novel long-lived materials were increasingly manufactured, known as the Great Acceleration (in Earth system terms) and the beginning of the Cold War (in historical terms), marked as a golden spike by the peak in radionuclide fallout in 1964. We finish by noting that the Anthropocene debate is politically loaded, thus transparency in the presentation of evidence is essential if a formal definition of the Anthropocene is to avoid becoming a debate about bias. The

  7. Explicit, Latent and Meta-Criteria: Types of Criteria at Play in Professional Judgement Practice

    ERIC Educational Resources Information Center

    Wyatt-Smith, Claire; Klenowski, Val

    2013-01-01

    This paper engages with debates about whether comprehensive prior specification of criteria and standards is sufficient for informed professional judgement. A preoccupation has emerged with the specificity and explication of criteria intended to regulate judgement. This has resulted in criteria compliance in the use of defined standards to…

  8. Searching the perfect ultrasonic classification in assessing carotid artery stenosis: comparison and remarks upon the existing ultrasound criteria.

    PubMed

    Mozzini, Chiara; Roscia, Giuseppe; Casadei, Alder; Cominacini, Luciano

    2016-01-01

    Doppler ultrasound scanning is the first line investigation for quantifying the internal carotid artery stenosis. Nevertheless, the lack of internationally accepted ultrasound criteria for describing the degree of stenosis has contributed to the different and confusing measurements ranges. The use of two different angiographic methods, the North American Symptomatic Carotid Endoarterectomy Study and the European Carotid Surgery Trial was probably the major initial source of confusion in deriving valid and reliable duplex ultrasound criteria worldwide. The consensus proposed in 2003 by the Society of Radiologists in Ultrasound has been a great attempt to create a conformity document, establishing grey scale and Doppler criteria in considering the different degrees of stenosis. According to this attempt, in 2010, the multi-parametric Deutsche Gesellschaft für Ultraschall in der Medizin ultrasound criteria have been proposed with a precise differentiation between main and additional criteria and depicted a different peak systolic velocity (PSV) threshold. In 2012, these criteria have been implemented, focusing on the multi-parametric approach, re-defining the PSV values and clearly introducing the concept of PSV average. Despite these attempts, a wide range of practice patterns still exists, with consistent disparities in patients' care. This paper collects these previous experiences and summarizes their strengths and weaknesses, to give a contribution in the carotid artery stenosis grading standardization using ultrasonic methods. Carotid ultrasound as the only diagnostic tool for the selection of patients for carotid surgery or stenting will be possible only with internationally accepted criteria.

  9. Searching the perfect ultrasonic classification in assessing carotid artery stenosis: comparison and remarks upon the existing ultrasound criteria.

    PubMed

    Mozzini, Chiara; Roscia, Giuseppe; Casadei, Alder; Cominacini, Luciano

    2016-01-01

    Doppler ultrasound scanning is the first line investigation for quantifying the internal carotid artery stenosis. Nevertheless, the lack of internationally accepted ultrasound criteria for describing the degree of stenosis has contributed to the different and confusing measurements ranges. The use of two different angiographic methods, the North American Symptomatic Carotid Endoarterectomy Study and the European Carotid Surgery Trial was probably the major initial source of confusion in deriving valid and reliable duplex ultrasound criteria worldwide. The consensus proposed in 2003 by the Society of Radiologists in Ultrasound has been a great attempt to create a conformity document, establishing grey scale and Doppler criteria in considering the different degrees of stenosis. According to this attempt, in 2010, the multi-parametric Deutsche Gesellschaft für Ultraschall in der Medizin ultrasound criteria have been proposed with a precise differentiation between main and additional criteria and depicted a different peak systolic velocity (PSV) threshold. In 2012, these criteria have been implemented, focusing on the multi-parametric approach, re-defining the PSV values and clearly introducing the concept of PSV average. Despite these attempts, a wide range of practice patterns still exists, with consistent disparities in patients' care. This paper collects these previous experiences and summarizes their strengths and weaknesses, to give a contribution in the carotid artery stenosis grading standardization using ultrasonic methods. Carotid ultrasound as the only diagnostic tool for the selection of patients for carotid surgery or stenting will be possible only with internationally accepted criteria. PMID:27298648

  10. Quantum cryptography: Security criteria reexamined

    SciTech Connect

    Kaszlikowski, Dagomir; Liang, Y.C.; Englert, Berthold-Georg; Gopinathan, Ajay; Kwek, L.C.

    2004-09-01

    We find that the generally accepted security criteria are flawed for a whole class of protocols for quantum cryptography. This is so because a standard assumption of the security analysis, namely that the so-called square-root measurement is optimal for eavesdropping purposes, is not true in general. There are rather large parameter regimes in which the optimal measurement extracts substantially more information than the square-root measurement.

  11. Acceptance criteria for reactor coolant pumps and valves

    SciTech Connect

    Gupta, N.K.; Miller, R.F.; Sindelar, R.L.

    1993-05-01

    Each of the six primary coolant loop systems of the Savannah River Site (SRS) production reactors contains one reactor coolant pump, one PUMP suction side motor operated valve, and other smaller valves. The pumps me double suction, double volute, and radially split type pumps. The valves are different size shutoff and control valves rated from ANSI B16.5 construction class 150 to class 300. The reactor coolant system components, also known as the process water system (PWS), are classified as nuclear Safety Class I components. These components were constructed in the 1950`s in accordance with the then prevailing industry practices. No uniform construction codes were used for design and analysis of these components. However, no pressure boundary failures or bolting failures have ever been recorded throughout their operating history. Over the years, the in-service inspection (ISI) was limited to visual inspection of the pressure boundaries, and surface and volumetric examination of the pressure retaining bolts. Efforts are now underway to implement ISI requirements similar to the ASME Section XI requirements for pumps and valves. This report discusses the new ISI requirements which also call for volumetric examination of the pump casing and valve body welds.

  12. 46 CFR 164.120-7 - Acceptance criteria.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ASTM D 695 241 MPa (35,000 ln/in2). (v) Fire retardant MSC Circ. 1006 Pass. (vi) Water absorption, 24... hours in boiling distilled water as per ASTM D 570 paragraph 7.5. The specimens must then be cooled in water at 23 °C and tested wet at standard conditions immediately after removal from the water.):...

  13. 46 CFR 164.120-7 - Acceptance criteria.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... inspections and tests required by this section, including weathering of samples, are the responsibility of the... of this subpart) and must be tested and meet the requirements of weathering and post-weathering mechanical testing as shown in Table 164.120-7 of this section. Samples for the weathering must be...

  14. DWPF COAL CARBON WASTE ACCEPTANCE CRITERIA LIMIT EVALUATION

    SciTech Connect

    Lambert, D.; Choi, A.

    2010-06-21

    A paper study was completed to assess the impact on the Defense Waste Processing Facility (DWPF)'s Chemical Processing Cell (CPC) acid addition and melter off-gas flammability control strategy in processing Sludge Batch 10 (SB10) to SB13 with an added Fluidized Bed Steam Reformer (FBSR) stream and two Salt Waste Processing Facility (SWPF) products (Strip Effluent and Actinide Removal Stream). In all of the cases that were modeled, an acid mix using formic acid and nitric acid could be achieved that would produce a predicted Reducing/Oxidizing (REDOX) Ratio of 0.20 Fe{sup +2}/{Sigma}Fe. There was sufficient formic acid in these combinations to reduce both the manganese and mercury present. Reduction of manganese and mercury are both necessary during Sludge Receipt and Adjustment Tank (SRAT) processing, however, other reducing agents such as coal and oxalate are not effective in this reduction. The next phase in this study will be experimental testing with SB10, FBSR, and both SWPF simulants to validate the assumptions in this paper study and determine whether there are any issues in processing these streams simultaneously. The paper study also evaluated a series of abnormal processing conditions to determine whether potential abnormal conditions in FBSR, SWPF or DWPF would produce melter feed that was too oxidizing or too reducing. In most of the cases that were modeled with one parameter at its extreme, an acid mix using formic acid and nitric acid could be achieved that would produce a predicted REDOX of 0.09-0.30 (target 0.20). However, when a run was completed with both high coal and oxalate, with minimum formic acid to reduce mercury and manganese, the final REDOX was predicted to be 0.49 with sludge and FBSR product and 0.47 with sludge, FBSR product and both SWPF products which exceeds the upper REDOX limit.

  15. 49 CFR 173.57 - Acceptance criteria for new explosives.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... must be subjected to the Drop Weight Impact Sensitivity Test (Test Method 3(a)(i)), the Friction... substance has a friction sensitiveness equal to or greater than that of dry pentaerythrite tetranitrate (PETN) when tested in the Friction Sensitivity Test; (4) The substance fails to pass the test...

  16. 49 CFR 173.57 - Acceptance criteria for new explosives.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... must be subjected to the Drop Weight Impact Sensitivity Test (Test Method 3(a)(i)), the Friction... substance has a friction sensitiveness equal to or greater than that of dry pentaerythrite tetranitrate (PETN) when tested in the Friction Sensitivity Test; (4) The substance fails to pass the test...

  17. 49 CFR 173.57 - Acceptance criteria for new explosives.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... must be subjected to the Drop Weight Impact Sensitivity Test (Test Method 3(a)(i)), the Friction... substance has a friction sensitiveness equal to or greater than that of dry pentaerythrite tetranitrate (PETN) when tested in the Friction Sensitivity Test; (4) The substance fails to pass the test...

  18. 49 CFR 173.57 - Acceptance criteria for new explosives.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... must be subjected to the Drop Weight Impact Sensitivity Test (Test Method 3(a)(i)), the Friction... substance has a friction sensitiveness equal to or greater than that of dry pentaerythrite tetranitrate (PETN) when tested in the Friction Sensitivity Test; (4) The substance fails to pass the test...

  19. 46 CFR 164.120-7 - Acceptance criteria.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS...) Ultimate strength, flatwise ISO 14125 or ASTM D 790 345 MPa (50,000 lb/in2). (ii) Initial modulus of...) Ultimate strength, flatwise ISO 14125 or ASTM D 790 310 MPa (45,000 lb/in2). (ii) Initial modulus...

  20. 7 CFR 42.133 - Portion of production acceptance criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 42.133 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS STANDARDS FOR CONDITION OF FOOD CONTAINERS On-Line Sampling and Inspection...

  1. 7 CFR 42.133 - Portion of production acceptance criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 42.133 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS STANDARDS FOR CONDITION OF FOOD CONTAINERS On-Line Sampling and Inspection...

  2. Photovoltaic system criteria documents. Volume 3: Environmental issues and evaluation criteria for photovoltaic applications

    NASA Technical Reports Server (NTRS)

    Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

    1979-01-01

    The environmental issues and evaluation criteria relating to the suitability of sites proposed for photovoltaic (PV) system deployment are identified. The important issues are defined, briefly discussed and then developed into evaluation criteria. System designers are provided with information on the environmental sensitivity of PV systems in realistic applications, background material which indicates the applicability of the siting issues identified, and evaluation criteria are defined to facilitate the selection of sites that maximize PV system operation.

  3. Will patients accept randomization to psychoanalysis? A feasibility study.

    PubMed

    Caligor, Eve; Hilsenroth, Mark J; Devlin, Michael; Rutherford, Bret R; Terry, Madeleine; Roose, Steven P

    2012-04-01

    The feasibility of using a randomized design in a psychoanalytic outcome study was evaluated. Our hypothesis was that it would be feasible to randomize patients to psychoanalysis three or four times weekly on the couch for five years, supportive expressive therapy once or twice weekly for up to forty sessions, and cognitive behavior therapy once or twice weekly for up to forty sessions. Successful randomization was defined as a 30% recruitment rate among eligible patients. Recruitment began in September 2009 and closed in April 2010. A total of 132 subjects responded to study advertisements, 107 of whom (81%) were triaged out. The remaining 25 were scheduled for the first of two clinical interviews, and 21 of 25 (88%) completed the interview. Eleven of the 25 (44%) were determined to be eligible based on inclusion and exclusion criteria. Eight of the 11 accepted the idea of randomization and completed the diagnostic assessment phase. Calculated on the basis of 8 of 11 eligible patients accepting randomization, the 95% confidence interval was that 39% to 92% of eligible subjects would participate in a larger study of this design. Our findings support the feasibility of implementing an RCT comparing psychoanalysis as defined by the American Psychoanalytic Association (three or four times weekly on the couch for approximately five years) with shorter-term dynamic or cognitive behavioral therapy once or twice a week. Pre-treatment characteristics of these eight patients are presented, as are initial reliability data for the treatment adherence scales used in this trial.

  4. Educational Wikis: Features and Selection Criteria

    ERIC Educational Resources Information Center

    Schwartz, Linda; Clark, Sharon; Cossarin, Mary; Rudolph, Jim

    2004-01-01

    This report discusses the educational uses of the "wiki," an increasingly popular approach to online community development. Wikis are defined and compared with "blogging" methods; characteristics of major wiki engines are described; and wiki features and selection criteria are examined.

  5. Offer/Acceptance Ratio.

    ERIC Educational Resources Information Center

    Collins, Mimi

    1997-01-01

    Explores how human resource professionals, with above average offer/acceptance ratios, streamline their recruitment efforts. Profiles company strategies with internships, internal promotion, cooperative education programs, and how to get candidates to accept offers. Also discusses how to use the offer/acceptance ratio as a measure of program…

  6. Acceptance Test Procedure for Cathodic Protection, Rectifier 11

    SciTech Connect

    Clifton, F.T.

    1995-04-28

    This Acceptance Test Procedure for Project W-030 Cathodic Protection Installation, 241-AY and 241-AZ Tank Farm Ventilation Upgrade, has been prepared to demonstrate that the cathodic protection system functions as required by project criteria.

  7. Defining recovery in adult bulimia nervosa.

    PubMed

    Yu, Jessica; Agras, W Stewart; Bryson, Susan

    2013-01-01

    To examine how different definitions of recovery lead to varying rates of recovery, maintenance of recovery, and relapse in bulimia nervosa (BN), end-of-treatment (EOT) and follow-up data were obtained from 96 adults with BN. Combining behavioral, physical, and psychological criteria led to recovery rates between 15.5% and 34.4% at EOT, though relapse was approximately 50%. Combining these criteria and requiring abstinence from binge eating and purging when defining recovery may lead to lower recovery rates than those found in previous studies; however, a strength of this definition is that individuals who meet this criteria have no remaining disordered behaviors or symptoms.

  8. MDS clinical diagnostic criteria for Parkinson's disease.

    PubMed

    Postuma, Ronald B; Berg, Daniela; Stern, Matthew; Poewe, Werner; Olanow, C Warren; Oertel, Wolfgang; Obeso, José; Marek, Kenneth; Litvan, Irene; Lang, Anthony E; Halliday, Glenda; Goetz, Christopher G; Gasser, Thomas; Dubois, Bruno; Chan, Piu; Bloem, Bastiaan R; Adler, Charles H; Deuschl, Günther

    2015-10-01

    This document presents the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (PD). The Movement Disorder Society PD Criteria are intended for use in clinical research but also may be used to guide clinical diagnosis. The benchmark for these criteria is expert clinical diagnosis; the criteria aim to systematize the diagnostic process, to make it reproducible across centers and applicable by clinicians with less expertise in PD diagnosis. Although motor abnormalities remain central, increasing recognition has been given to nonmotor manifestations; these are incorporated into both the current criteria and particularly into separate criteria for prodromal PD. Similar to previous criteria, the Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity. Explicit instructions for defining these cardinal features are included. After documentation of parkinsonism, determination of PD as the cause of parkinsonism relies on three categories of diagnostic features: absolute exclusion criteria (which rule out PD), red flags (which must be counterbalanced by additional supportive criteria to allow diagnosis of PD), and supportive criteria (positive features that increase confidence of the PD diagnosis). Two levels of certainty are delineated: clinically established PD (maximizing specificity at the expense of reduced sensitivity) and probable PD (which balances sensitivity and specificity). The Movement Disorder Society criteria retain elements proven valuable in previous criteria and omit aspects that are no longer justified, thereby encapsulating diagnosis according to current knowledge. As understanding of PD expands, the Movement Disorder Society criteria will need continuous revision to accommodate these advances.

  9. The challenge of defining risk-based metrics to improve food safety: inputs from the BASELINE project.

    PubMed

    Manfreda, Gerardo; De Cesare, Alessandra

    2014-08-01

    In 2002, the Regulation (EC) 178 of the European Parliament and of the Council states that, in order to achieve the general objective of a high level of protection of human health and life, food law shall be based on risk analysis. However, the Commission Regulation No 2073/2005 on microbiological criteria for foodstuffs requires that food business operators ensure that foodstuffs comply with the relevant microbiological criteria. Such criteria define the acceptability of a product, a batch of foodstuffs or a process, based on the absence, presence or number of micro-organisms, and/or on the quantity of their toxins/metabolites, per unit(s) of mass, volume, area or batch. The same Regulation describes a food safety criterion as a mean to define the acceptability of a product or a batch of foodstuff applicable to products placed on the market; moreover, it states a process hygiene criterion as a mean indicating the acceptable functioning of the production process. Both food safety criteria and process hygiene criteria are not based on risk analysis. On the contrary, the metrics formulated by the Codex Alimentarius Commission in 2004, named Food Safety Objective (FSO) and Performance Objective (PO), are risk-based and fit the indications of Regulation 178/2002. The main aims of this review are to illustrate the key differences between microbiological criteria and the risk-based metrics defined by the Codex Alimentarius Commission and to explore the opportunity and also the possibility to implement future European Regulations including PO and FSO as supporting parameters to microbiological criteria. This review clarifies also the implications of defining an appropriate level of human protection, how to establish FSO and PO and how to implement them in practice linked to each other through quantitative risk assessment models. The contents of this review should clarify the context for application of the results collected during the EU funded project named BASELINE (www

  10. Treatment results of acromegaly as analyzed by different criteria.

    PubMed

    van Lindert, E; Hey, O; Boecher-Schwarz, H; Perneczky, A

    1997-01-01

    Results of treatment of acromegaly are often incomparable due to the different criteria which have been used for defining cure or control of disease. At the present time it is widely accepted, that the main criteria of cure must be normalization of IGF-1 and a GH in the OGTT < 2 ng/ml. In this retrospective study we investigated the endocrinological results of 56 patients, who were surgically treated because of a GH-producing pituitary adenoma, by different criteria. Twelve of our patients had had additional medical treatment after surgery, two received radiotherapy. At a mean follow-up of 34 months after surgery 66% of patients had a basal GH < 5 ng/ml, 64% had a GH in the OGTT < 2 ng/ml and 73% had normalization of IGF-1. The combined criteria of OGTT < 2 ng/ml and IGF-1 normalization have been fulfilled in 59% of patients. None of these latter patients developed a clinical recurrence during the follow-up period. An optimal result (endocrinological cure, no permanent surgical complications and intact pituitary function) was achieved in 43% of patients. Although surgery was responsible for 19 new pituitary axis deficiencies (7 corticotropic axis, 8 thyrotropic axis and gonadotropic axis), 22 partial deficiencies improved to normalization after surgery (respectively 6, 3, and 13). Pre-operatively 55% of patients had no pituitary deficiency, after surgery this was 61%, leaving a net positive result of 6% less pituitary deficiencies. The authors conclude that normalization of IGF-1 combined with an OGTT < 2 ng/ml are adequate criteria for the definition of cure of acromegaly. However, the authors propose to include post-treatment hypopituitarism as an additional criterion by which treatment of acromegaly should be evaluated. PMID:9401649

  11. Common criteria for usability review.

    PubMed

    Nassar, Victor

    2012-01-01

    The propose of this paper is to present a literature review, in a grouping of common criteria for usability approaches of Bastien and Scapin (1993), Nielsen (1994), Shnneiderman(1998), Dix et al (1998), Preece et al (2005) and ISO 9241-110 (2006). After establishment of prerequisites for knowledge of the general characteristics of the users who will use the system, are defined and explained the criteria in common: consistency, user control, ease of learning, flexibility, errors management, reduction of excess and visibility system status. Although there is no determination as to which criteria should be considered when developing an interface and each author presents some specificity in their approach, it is observed that there is equivalence in the measures adopted usability. PMID:22316859

  12. TU-C-BRE-08: IMRT QA: Selecting Meaningful Gamma Criteria Based On Error Detection Sensitivity

    SciTech Connect

    Steers, J; Fraass, B

    2014-06-15

    Purpose: To develop a strategy for defining meaningful tolerance limits and studying the sensitivity of IMRT QA gamma criteria by inducing known errors in QA plans. Methods: IMRT QA measurements (ArcCHECK, Sun Nuclear) were compared to QA plan calculations with induced errors. Many (>24) gamma comparisons between data and calculations were performed for each of several kinds of cases and classes of induced error types with varying magnitudes (e.g. MU errors ranging from -10% to +10%), resulting in over 3,000 comparisons. Gamma passing rates for each error class and case were graphed against error magnitude to create error curves in order to represent the range of missed errors in routine IMRT QA using various gamma criteria. Results: This study demonstrates that random, case-specific, and systematic errors can be detected by the error curve analysis. Depending on location of the peak of the error curve (e.g., not centered about zero), 3%/3mm threshold=10% criteria may miss MU errors of up to 10% and random MLC errors of up to 5 mm. Additionally, using larger dose thresholds for specific devices may increase error sensitivity (for the same X%/Ymm criteria) by up to a factor of two. This analysis will allow clinics to select more meaningful gamma criteria based on QA device, treatment techniques, and acceptable error tolerances. Conclusion: We propose a strategy for selecting gamma parameters based on the sensitivity of gamma criteria and individual QA devices to induced calculation errors in QA plans. Our data suggest large errors may be missed using conventional gamma criteria and that using stricter criteria with an increased dose threshold may reduce the range of missed errors. This approach allows quantification of gamma criteria sensitivity and is straightforward to apply to other combinations of devices and treatment techniques.

  13. Final waste forms project: Performance criteria for phase I treatability studies

    SciTech Connect

    Gilliam, T.M.; Hutchins, D.A.; Chodak, P. III

    1994-06-01

    This document defines the product performance criteria to be used in Phase I of the Final Waste Forms Project. In Phase I, treatability studies will be performed to provide {open_quotes}proof-of-principle{close_quotes} data to establish the viability of stabilization/solidification (S/S) technologies. This information is required by March 1995. In Phase II, further treatability studies, some at the pilot scale, will be performed to provide sufficient data to allow treatment alternatives identified in Phase I to be more fully developed and evaluated, as well as to reduce performance uncertainties for those methods chosen to treat a specific waste. Three main factors influence the development and selection of an optimum waste form formulation and hence affect selection of performance criteria. These factors are regulatory, process-specific, and site-specific waste form standards or requirements. Clearly, the optimum waste form formulation will require consideration of performance criteria constraints from each of the three categories. Phase I will focus only on the regulatory criteria. These criteria may be considered the minimum criteria for an acceptable waste form. In other words, a S/S technology is considered viable only if it meet applicable regulatory criteria. The criteria to be utilized in the Phase I treatability studies were primarily taken from Environmental Protection Agency regulations addressed in 40 CFR 260 through 265 and 268; and Nuclear Regulatory Commission regulations addressed in 10 CFR 61. Thus the majority of the identified criteria are independent of waste form matrix composition (i.e., applicable to cement, glass, organic binders etc.).

  14. Determination of criteria weights in solving multi-criteria problems

    NASA Astrophysics Data System (ADS)

    Kasim, Maznah Mat

    2014-12-01

    A multi-criteria (MC) problem comprises of units to be analyzed under a set of evaluation criteria. Solving a MC problem is basically the process of finding the overall performance or overall quality of the units of analysis by using certain aggregation method. Based on these overall measures of each unit, a decision can be made whether to sort them, to select the best or to group them according to certain ranges. Prior to solving the MC problems, the weights of the related criteria have to be determined with the assumption that the weights represent the degree of importance or the degree of contribution towards the overall performance of the units. This paper presents two main approaches which are called as subjective and objective approaches, where the first one involves evaluator(s) while the latter approach depends on the intrinsic information contained in each criterion. The subjective and objective weights are defined if the criteria are assumed to be independent with each other, but if they are dependent, there is another type of weight, which is called as monotone measure weight or compound weights which represent degree of interaction among the criteria. The measure of individual weights or compound weights must be addressed in solving multi-criteria problems so that the solutions are more reliable since in the real world, evaluation criteria always come with different degree of importance or are dependent with each other. As the real MC problems have their own uniqueness, it is up to the decision maker(s) to decide which type of weights and which method are the most applicable ones for the problem under study.

  15. Early Site Permit Demonstration Program: Regulatory criteria evaluation report. Appendix E

    SciTech Connect

    Not Available

    1993-03-01

    The primary objective of the Early Site Permit Demonstration Program (ESPDP) is to demonstrate successfully the use of 10CFR52 to obtain ESPs for one or more US sites for one (or more) ALWR nuclear power plants. It is anticipated that preparation of the ESP application and interaction with NRC during the application review process will result not only in an ESP for the applicant(s) but also in the development of criteria and definition of processes, setting the precedent that facilitates ESPs for subsequent ESP applications. Because siting regulatory processes and acceptance criteria are contained in over 100 separate documents, comprehensive licensing and technical reviews were performed to establish whether the requirements and documentation are self-consistent, whether the acceptance criteria are sufficiently well-defined and clear, and whether the licensing process leading to the issuance of an ESP is unambiguously specified. This document provides Appendix E which contains a population density report. In this study the proposed US Nuclear Regulatory Commission (NRC) population density and exclusion zone size criteria were evaluated for their potential effectiveness to meet the quantitative public health and safety objectives associated with the NRC Safety Goal Policy. In addition, the individual and societal risks from postulated accidents (based on NUREG-1150 methods) were determined and compared to the quantitative prompt and latent health objective of the safety goal policy.

  16. 16 CFR 1616.4 - Sampling and acceptance procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Sampling and acceptance procedures. 1616.4... Sampling and acceptance procedures. (a) General. (1) The test criteria of § 1616.3(b) shall be used in conjunction with the following fabric and garment sampling plan. The Consumer Product Safety Commission...

  17. 16 CFR 1616.4 - Sampling and acceptance procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Sampling and acceptance procedures. 1616.4... Sampling and acceptance procedures. (a) General. (1) The test criteria of § 1616.3(b) shall be used in conjunction with the following fabric and garment sampling plan. The Consumer Product Safety Commission...

  18. 16 CFR 1616.4 - Sampling and acceptance procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Sampling and acceptance procedures. 1616.4... Sampling and acceptance procedures. (a) General. (1) The test criteria of § 1616.3(b) shall be used in conjunction with the following fabric and garment sampling plan. The Consumer Product Safety Commission...

  19. Behavioral genetics: scientific and social acceptance.

    PubMed

    Lorenz, David R

    2003-01-01

    Human behavioral genetics can be broadly defined as the attempt to characterize and define the genetic or hereditary basis for human behavior. Examination of the history of these scientific enterprises reveals episodes of controversy, and an apparent distinction between scientific and social acceptance of the genetic nature of such complex behaviors. This essay will review the history and methodology of behavioral genetics research, including a more detailed look at case histories involving behavioral genetic research for aggressive behavior and alcoholism. It includes a discussion of the scientific versus social qualities of the acceptance of behavioral genetics research, as well as the development of a general model for scientific acceptance involving the researchers, the scientific literature, the scientific peer group, the mainstream media, and the public at large. From this model follows a discussion of the means and complications by which behavioral genetics research may be accepted by society, and an analysis of how future studies might be conducted.

  20. IHE material qualification tests description and criteria

    SciTech Connect

    Slape, R J

    1984-06-01

    This report describes the qualification tests presently being used at Pantex Plant, Lawrence Livermore National Laboratory, and Los Alamos National Laboratory that are required by the Department of Energy prior to the approval for an explosive as an Insensitive High Explosive (IHE) material. The acceptance criteria of each test for IHE qualification is also discussed. 5 references, 10 figures.

  1. A National Survey of State Legislation defining mental retardation: implications for policy and practice after Atkins.

    PubMed

    DeMatteo, David; Marczyk, Geoffrey; Pich, Michele

    2007-01-01

    In Atkins v. Virginia 2002, the U.S. Supreme Court held that the Eighth Amendment prohibits executing offenders who are mentally retarded. Rather than adopting a uniform definition of mental retardation, the court charged each state with defining mental retardation in a manner that enforces the constitutional restriction. An unanswered question is how states define mental retardation after Atkins, which has implications for capital defendants and forensic evaluators who conduct capital mitigation evaluations. This project identified the statutory definitions of mental retardation in each state, and grouped the definitions based on consistency with accepted clinical criteria for mental retardation. Results show that definitions of mental retardation vary considerably by state. The large majority of states, both overall and specifically among death penalty states, use criteria for mental retardation that are not entirely consistent with accepted clinical standards. As such, it is not clear whether the majority of states are effectuating the intent of Atkins. The implications of these findings for both policy and practice are discussed.

  2. Acceptability of BCG vaccination.

    PubMed

    Mande, R

    1977-01-01

    The acceptability of BCG vaccination varies a great deal according to the country and to the period when the vaccine is given. The incidence of complications has not always a direct influence on this acceptability, which depends, for a very large part, on the risk of tuberculosis in a given country at a given time.

  3. ATLAS ACCEPTANCE TEST

    SciTech Connect

    Cochrane, J. C. , Jr.; Parker, J. V.; Hinckley, W. B.; Hosack, K. W.; Mills, D.; Parsons, W. M.; Scudder, D. W.; Stokes, J. L.; Tabaka, L. J.; Thompson, M. C.; Wysocki, Frederick Joseph; Campbell, T. N.; Lancaster, D. L.; Tom, C. Y.

    2001-01-01

    The acceptance test program for Atlas, a 23 MJ pulsed power facility for use in the Los Alamos High Energy Density Hydrodynamics program, has been completed. Completion of this program officially releases Atlas from the construction phase and readies it for experiments. Details of the acceptance test program results and of machine capabilities for experiments will be presented.

  4. TESTING AND ACCEPTANCE OF FUEL PLATES FOR RERTR FUEL DEVELOPMENT EXPERIMENTS

    SciTech Connect

    J.M. Wight; G.A. Moore; S.C. Taylor

    2008-10-01

    This paper discusses how candidate fuel plates for RERTR Fuel Development experiments are examined and tested for acceptance prior to reactor insertion. These tests include destructive and nondestructive examinations (DE and NDE). The DE includes blister annealing for dispersion fuel plates, bend testing of adjacent cladding, and microscopic examination of archive fuel plates. The NDE includes Ultrasonic (UT) scanning and radiography. UT tests include an ultrasonic scan for areas of “debonds” and a high frequency ultrasonic scan to determine the "minimum cladding" over the fuel. Radiography inspections include identifying fuel outside of the maximum fuel zone and measurements and calculations for fuel density. Details of each test are provided and acceptance criteria are defined. These tests help to provide a high level of confidence the fuel plate will perform in the reactor without a breach in the cladding.

  5. Understanding diversity: the importance of social acceptance.

    PubMed

    Chen, Jacqueline M; Hamilton, David L

    2015-04-01

    Two studies investigated how people define and perceive diversity in the historically majority-group dominated contexts of business and academia. We hypothesized that individuals construe diversity as both the numeric representation of racial minorities and the social acceptance of racial minorities within a group. In Study 1, undergraduates' (especially minorities') perceptions of campus diversity were predicted by perceived social acceptance on a college campus, above and beyond perceived minority representation. Study 2 showed that increases in a company's representation and social acceptance independently led to increases in perceived diversity of the company among Whites. Among non-Whites, representation and social acceptance only increased perceived diversity of the company when both qualities were high. Together these findings demonstrate the importance of both representation and social acceptance to the achievement of diversity in groups and that perceiver race influences the relative importance of these two components of diversity.

  6. Approaches to acceptable risk: a critical guide

    SciTech Connect

    Fischhoff, B.; Lichtenstein, S.; Slovic, P.; Keeney, R.; Derby, S.

    1980-12-01

    Acceptable-risk decisions are an essential step in the management of technological hazards. In many situations, they constitute the weak (or missing) link in the management process. The absence of an adequate decision-making methodology often produces indecision, inconsistency, and dissatisfaction. The result is neither good for hazard management nor good for society. This report offers a critical analysis of the viability of various approaches as guides to acceptable-risk decisions. This report seeks to define acceptable-risk decisions and to examine some frequently proposed, but inappropriate, solutions. 255 refs., 22 figs., 25 tabs.

  7. Institutional Quality Assessment of Higher Education: Dimensions, Criteria and Indicators

    ERIC Educational Resources Information Center

    Savickiene, Izabela; Pukelis, Kestutis

    2004-01-01

    The article discusses dimensions and criteria, which are used to assess the quality of higher education in different countries. The paper presents dimensions and criteria that could be appropriate for assessment of the quality of higher education at Lithuanian universities. Quality dimensions, assessment criteria and indicators are defined and…

  8. Alternative microbial methods: An overview and selection criteria.

    PubMed

    Jasson, Vicky; Jacxsens, Liesbeth; Luning, Pieternel; Rajkovic, Andreja; Uyttendaele, Mieke

    2010-09-01

    This study provides an overview and criteria for the selection of a method, other than the reference method, for microbial analysis of foods. In a first part an overview of the general characteristics of rapid methods available, both for enumeration and detection, is given with reference to relevant bibliography. Perspectives on future development and the potential of the rapid method for routine application in food diagnostics are discussed. As various alternative "rapid" methods in different formats are available on the market, it can be very difficult for a food business operator or for a control authority to select the most appropriate method which fits its purpose. Validation of a method by a third party, according to international accepted protocol based upon ISO 16140, may increase the confidence in the performance of a method. A list of at the moment validated methods for enumeration of both utility indicators (aerobic plate count) and hygiene indicators (Enterobacteriaceae, Escherichia coli, coagulase positive Staphylococcus) as well as for detection of the four major pathogens (Salmonella spp., Listeria monocytogenes, E. coli O157 and Campylobacter spp.) is included with reference to relevant websites to check for updates. In a second part of this study, selection criteria are introduced to underpin the choice of the appropriate method(s) for a defined application. The selection criteria link the definition of the context in which the user of the method functions - and thus the prospective use of the microbial test results - with the technical information on the method and its operational requirements and sustainability. The selection criteria can help the end user of the method to obtain a systematic insight into all relevant factors to be taken into account for selection of a method for microbial analysis. PMID:20630313

  9. Acceptance procedures: Microfilm printer

    NASA Technical Reports Server (NTRS)

    Lockwood, H. E.

    1973-01-01

    Acceptance tests were made for a special order automatic additive color microfilm printer. Tests include film capacity, film transport, resolution, illumination uniformity, exposure range checks, and color cuing considerations.

  10. Defining Early Adolescent Childbearing.

    ERIC Educational Resources Information Center

    Phipps, Maureen G.; Sowers, MaryFran

    2002-01-01

    Determined the age group for defining early adolescent childbearing based on rates of adverse clinical outcomes. Data on infant mortality, very low birth weight, and very pre-term delivery per 1,000 live births for women age 12-23 years in the 1995 U.S. birth cohort indicate that early adolescent childbearing is best defined as giving birth at age…

  11. 33 CFR 155.1065 - Procedures for plan submission, approval, requests for acceptance of alternative planning...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., approval, requests for acceptance of alternative planning criteria, and appeal. 155.1065 Section 155.1065....1065 Procedures for plan submission, approval, requests for acceptance of alternative planning criteria... certifying that the plan meets the applicable requirements of subparts D, E, F, and G of this part and...

  12. Proposal of success criteria for strabismus surgery in patients with Graves' orbitopathy based on a systematic literature review.

    PubMed

    Jellema, Hinke Marijke; Braaksma-Besselink, Yvette; Limpens, Jacqueline; von Arx, Georg; Wiersinga, Wilmar M; Mourits, Maarten P

    2015-11-01

    Proposal of success criteria for strabismus surgery for patients with Graves' orbitopathy (GO) based on a systematic review of the literature. We performed a systematic search of OVID MEDLINE, OVID Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and the publisher subset of PubMed, to identify studies reporting on success criteria of strabismus surgery in GO. In addition, we handsearched several orthoptic journals and proceedings of strabismological congresses. Of the 789 articles retrieved, 42 articles described success criteria for strabismus surgery in GO. Most studies defined success in terms of a subjective diplopia-free field in primary and down gaze. Almost half of the studies used a graded scale (excellent, good, acceptable and failure) to describe the outcome of surgery. Three of the eligible studies described a tool to quantify the field of single vision in detail. Quality of life was not reported as an outcome measure in any of the published studies. In conclusion, success criteria for strabismus surgery in patients with GO are poorly defined and no consensus is available. The lack of standardization hampers comparative studies and thus the search for the best surgical treatment for diplopia in patients with GO. Therefore, we propose strict success criteria including a tool for quantification of remaining diplopia plus a disease-specific quality of life questionnaire (the GO-QoL).

  13. Proposal of success criteria for strabismus surgery in patients with Graves' orbitopathy based on a systematic literature review.

    PubMed

    Jellema, Hinke Marijke; Braaksma-Besselink, Yvette; Limpens, Jacqueline; von Arx, Georg; Wiersinga, Wilmar M; Mourits, Maarten P

    2015-11-01

    Proposal of success criteria for strabismus surgery for patients with Graves' orbitopathy (GO) based on a systematic review of the literature. We performed a systematic search of OVID MEDLINE, OVID Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and the publisher subset of PubMed, to identify studies reporting on success criteria of strabismus surgery in GO. In addition, we handsearched several orthoptic journals and proceedings of strabismological congresses. Of the 789 articles retrieved, 42 articles described success criteria for strabismus surgery in GO. Most studies defined success in terms of a subjective diplopia-free field in primary and down gaze. Almost half of the studies used a graded scale (excellent, good, acceptable and failure) to describe the outcome of surgery. Three of the eligible studies described a tool to quantify the field of single vision in detail. Quality of life was not reported as an outcome measure in any of the published studies. In conclusion, success criteria for strabismus surgery in patients with GO are poorly defined and no consensus is available. The lack of standardization hampers comparative studies and thus the search for the best surgical treatment for diplopia in patients with GO. Therefore, we propose strict success criteria including a tool for quantification of remaining diplopia plus a disease-specific quality of life questionnaire (the GO-QoL). PMID:25876459

  14. Acceptance Priority Ranking & Annual Capacity Report

    SciTech Connect

    2004-07-31

    The Nuclear Waste Policy Act of 1982, as amended (the Act), assigns the Federal Government the responsibility for the disposal of spent nuclear fuel and high-level waste. Section 302(a) of the Act authorizes the Secretary to enter into contracts with the owners and generators of commercial spent nuclear fuel and/or high-level waste. The Standard Contract for Disposal of Spent Nuclear Fuel and/or High-Level Radioactive Waste (Standard Contract) established the contractual mechanism for the Department's acceptance and disposal of spent nuclear fuel and high-level waste. It includes the requirements and operational responsibilities of the parties to the Standard Contract in the areas of administrative matters, fees, terms of payment, waste acceptance criteria, and waste acceptance procedures. The Standard Contract provides for the acquisition of title to the spent nuclear fuel and/or high-level waste by the Department, its transportation to Federal facilities, and its subsequent disposal.

  15. Redefining design criteria for Pu-238 gloveboxes

    SciTech Connect

    Acosta, S.V.

    1998-12-31

    Enclosures for confinement of special nuclear materials (SNM) have evolved into the design of gloveboxes. During the early stages of glovebox technology, established practices and process operation requirements defined design criteria. Proven boxes that performed and met or exceeded process requirements in one group or area, often could not be duplicated in other areas or processes, and till achieve the same success. Changes in materials, fabrication and installation methods often only met immediate design criteria. Standardization of design criteria took a big step during creation of ``Special-Nuclear Materials R and D Laboratory Project, Glovebox standards``. The standards defined design criteria for every type of process equipment in its most general form. Los Alamos National Laboratory (LANL) then and now has had great success with Pu-238 processing. However with ever changing Environment Safety and Health (ES and H) requirements and Ta-55 Facility Configuration Management, current design criteria are forced to explore alternative methods of glovebox design fabrication and installation. Pu-238 fuel processing operations in the Power Source Technologies Group have pushed the limitations of current design criteria. More than half of Pu-238 gloveboxes are being retrofitted or replaced to perform the specific fuel process operations. Pu-238 glovebox design criteria are headed toward process designed single use glovebox and supporting line gloveboxes. Gloveboxes that will house equipment and processes will support TA-55 Pu-238 fuel processing needs into the next century and extend glovebox expected design life.

  16. Defining Overweight and Obesity

    MedlinePlus

    ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Defining Adult Overweight and ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs File Formats Help: How ...

  17. The Prognosis of IVF in Poor Responders Depending on the Bologna Criteria: A Large Sample Retrospective Study from China

    PubMed Central

    Yang, Shuo; Chen, Xinna; Zhen, Xiumei; Wang, Haiyan; Ma, Caihong; Li, Rong; Liu, Ping; Qiao, Jie

    2015-01-01

    Objective. To analyze the treatment outcomes of patients who accepted IVF/ICSI-ET, diagnosed POR according to Bologna criteria. Study Design. Retrospective cohort study of one reproductive medical center, from 1st Jan., 2009, to 31st Dec., 2014. All patients fulfilled the Bologna criteria and accept IVF/ICSI-ET treatment with stimulation cycle. The main outcome measures were clinical pregnancy rate (CPR) and live birth rate (LBR). Results. There were 5770 eligible cycles included in this study. The incidence of POR was 10.3% (6286/62194). The overall CPR was 18.7%, IR was 11.6%, LBR/ET was 11.5%, and LBR/OPU was 8.3%. The cycle cancellation for no available oocyte or embryo was 4.9% and 18.6%, respectively. The subgroup of younger POR patients got highest CPR and LBR/ET, which decreased while increasing maternal age. Within three attempts, the patients got similar CPR and LBR. Conclusion. In conclusion, our study supports the Bologna criteria that defined women with poor IVF outcomes. But those younger than 42 years old with the first 3 attempts of IVF could got acceptable CPR and LBR. PMID:26844227

  18. Criteria for environmentally associated autoimmune diseases.

    PubMed

    Miller, Frederick W; Pollard, K Michael; Parks, Christine G; Germolec, Dori R; Leung, Patrick S C; Selmi, Carlo; Humble, Michael C; Rose, Noel R

    2012-12-01

    Increasing evidence supports a role for the environment in the development of autoimmune diseases, as reviewed in the accompanying three papers from the National Institute of Environmental Health Sciences Expert Panel Workshop. An important unresolved issue, however, is the development of criteria for identifying autoimmune disease phenotypes for which the environment plays a causative role, herein referred to as environmentally associated autoimmune diseases. There are several different areas in which such criteria need to be developed, including: 1) identifying the necessary and sufficient data to define environmental risk factors for autoimmune diseases meeting current classification criteria; 2) establishing the existence of and criteria for new environmentally associated autoimmune disorders that do not meet current disease classification criteria; and 3) identifying in clinical practice specific environmental agents that induce autoimmune disease in individual patients. Here we discuss approaches that could be useful for developing criteria in these three areas, as well as factors that should be considered in evaluating the evidence for criteria that can distinguish individuals with such disorders from individuals without such disorders with high sensitivity and specificity. Current studies suggest that multiple lines of complementary evidence will be important and that in many cases there will be clinical, serologic, genetic, epigenetic, and/or other laboratory features that could be incorporated as criteria for environmentally associated autoimmune diseases to improve diagnosis and treatment and possibly allow for preventative strategies in the future.

  19. Defining the anthropocene.

    PubMed

    Lewis, Simon L; Maslin, Mark A

    2015-03-12

    Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record against the formal requirements for the recognition of a new epoch. The evidence suggests that of the various proposed dates two do appear to conform to the criteria to mark the beginning of the Anthropocene: 1610 and 1964. The formal establishment of an Anthropocene Epoch would mark a fundamental change in the relationship between humans and the Earth system.

  20. Defining the anthropocene.

    PubMed

    Lewis, Simon L; Maslin, Mark A

    2015-03-12

    Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record against the formal requirements for the recognition of a new epoch. The evidence suggests that of the various proposed dates two do appear to conform to the criteria to mark the beginning of the Anthropocene: 1610 and 1964. The formal establishment of an Anthropocene Epoch would mark a fundamental change in the relationship between humans and the Earth system. PMID:25762280

  1. Defining departmental mission.

    PubMed

    Hartman, M D; Barrow, J A; Sawyer, W R

    1990-02-01

    Mission statements have long been recognized by corporate America as a way to define an enterprise. The necessary business orientation of the health care industry requires that hospitals and hospital departments define their scope of services and reason for existence. The accelerating reprofessionalization affecting departments of pharmacy requires the same. "Improving the quality of patient care" can no longer represent a euphemism for simply reacting to external factors or acting on a whim without clear meaningful intent. Professional departments and hospitals must demonstrate a sense of direction and purpose and be able to justify costs to a budget-conscious management and skeptical public. Mission statements are not substitutes for a clearly defined sense of professional mission. However, well-constructed mission statements contribute to clarity of departmental and professional purpose and effective achievement of goals. PMID:10128549

  2. Defining Risk Drinking

    PubMed Central

    Dawson, Deborah A.

    2011-01-01

    Many efforts to prevent alcohol-related harm are aimed at reducing risk drinking. This article outlines the many conceptual and methodological challenges to defining risk drinking. It summarizes recent evidence regarding associations of various aspects of alcohol consumption with chronic and acute alcohol-related harms, including mortality, morbidity, injury, and alcohol use disorders, and summarizes the study designs most appropriate to defining risk thresholds for these types of harm. In addition, it presents an international overview of low-risk drinking guidelines from more than 20 countries, illustrating the wide range of interpretations of the scientific evidence related to risk drinking. This article also explores the impact of drink size on defining risk drinking and describes variation in what is considered to be a standard drink across populations. Actual and standard drink sizes differ in the United States, and this discrepancy affects definitions of risk drinking and prevention efforts. PMID:22330212

  3. Smaller hospitals accept advertising.

    PubMed

    Mackesy, R

    1988-07-01

    Administrators at small- and medium-sized hospitals gradually have accepted the role of marketing in their organizations, albeit at a much slower rate than larger institutions. This update of a 1983 survey tracks the increasing competitiveness, complexity and specialization of providing health care and of advertising a small hospital's services. PMID:10288550

  4. Students Accepted on Probation.

    ERIC Educational Resources Information Center

    Lorberbaum, Caroline S.

    This report is a justification of the Dalton Junior College admissions policy designed to help students who had had academic and/or social difficulties at other schools. These students were accepted on probation, their problems carefully analyzed, and much effort devoted to those with low academic potential. They received extensive academic and…

  5. Approaches to acceptable risk

    SciTech Connect

    Whipple, C.

    1997-04-30

    Several alternative approaches to address the question {open_quotes}How safe is safe enough?{close_quotes} are reviewed and an attempt is made to apply the reasoning behind these approaches to the issue of acceptability of radiation exposures received in space. The approaches to the issue of the acceptability of technological risk described here are primarily analytical, and are drawn from examples in the management of environmental health risks. These include risk-based approaches, in which specific quantitative risk targets determine the acceptability of an activity, and cost-benefit and decision analysis, which generally focus on the estimation and evaluation of risks, benefits and costs, in a framework that balances these factors against each other. These analytical methods tend by their quantitative nature to emphasize the magnitude of risks, costs and alternatives, and to downplay other factors, especially those that are not easily expressed in quantitative terms, that affect acceptance or rejection of risk. Such other factors include the issues of risk perceptions and how and by whom risk decisions are made.

  6. Why was Relativity Accepted?

    NASA Astrophysics Data System (ADS)

    Brush, S. G.

    Historians of science have published many studies of the reception of Einstein's special and general theories of relativity. Based on a review of these studies, and my own research on the role of the light-bending prediction in the reception of general relativity, I discuss the role of three kinds of reasons for accepting relativity (1) empirical predictions and explanations; (2) social-psychological factors; and (3) aesthetic-mathematical factors. According to the historical studies, acceptance was a three-stage process. First, a few leading scientists adopted the special theory for aesthetic-mathematical reasons. In the second stage, their enthusiastic advocacy persuaded other scientists to work on the theory and apply it to problems currently of interest in atomic physics. The special theory was accepted by many German physicists by 1910 and had begun to attract some interest in other countries. In the third stage, the confirmation of Einstein's light-bending prediction attracted much public attention and forced all physicists to take the general theory of relativity seriously. In addition to light-bending, the explanation of the advance of Mercury's perihelion was considered strong evidence by theoretical physicists. The American astronomers who conducted successful tests of general relativity became defenders of the theory. There is little evidence that relativity was `socially constructed' but its initial acceptance was facilitated by the prestige and resources of its advocates.

  7. What Defines a Separate Hydrothermal System

    SciTech Connect

    Lawless, J.V.; Bogie, I.; Bignall, G.

    1995-01-01

    Separate hydrothermal systems can be defined in a variety of ways. Criteria which have been applied include separation of heat source, upflow, economic resource and geophysical anomaly. Alternatively, connections have been defined by the effects of withdrawal of economically useful fluid and subsidence, effects of reinjection, changes in thermal features, or by a hydrological connection of groundwaters. It is proposed here that: ''A separate hydrothermal system is one that is fed by a separate convective upflow of fluid, at a depth above the brittle-ductile transition for the host rocks, while acknowledging that separate hydrothermal systems can be hydrologically interconnected at shallower levels''.

  8. Defining the Human Microbiome

    PubMed Central

    Ursell, Luke K; Metcalf, Jessica L; Parfrey, Laura Wegener; Knight, Rob

    2012-01-01

    Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how we define the microbiome and its constituents. In this review we highlight recent research that expands our ability to understand the human microbiome on different spatial and temporal scales, including daily timeseries datasets spanning months. Furthermore, we discuss emerging concepts related to defining operational taxonomic units, diversity indices, core versus transient microbiomes and the possibility of enterotypes. Additional advances in sequencing technology and in our understanding of the microbiome will provide exciting prospects for exploiting the microbiota for personalized medicine. PMID:22861806

  9. Plutonium storage criteria

    SciTech Connect

    Chung, D.; Ascanio, X.

    1996-05-01

    The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less than 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.

  10. Stability criteria for complex ecosystems.

    PubMed

    Allesina, Stefano; Tang, Si

    2012-03-01

    Forty years ago, May proved that sufficiently large or complex ecological networks have a probability of persisting that is close to zero, contrary to previous expectations. May analysed large networks in which species interact at random. However, in natural systems pairs of species have well-defined interactions (for example predator-prey, mutualistic or competitive). Here we extend May's results to these relationships and find remarkable differences between predator-prey interactions, which are stabilizing, and mutualistic and competitive interactions, which are destabilizing. We provide analytic stability criteria for all cases. We use the criteria to prove that, counterintuitively, the probability of stability for predator-prey networks decreases when a realistic food web structure is imposed or if there is a large preponderance of weak interactions. Similarly, stability is negatively affected by nestedness in bipartite mutualistic networks. These results are found by separating the contribution of network structure and interaction strengths to stability. Stable predator-prey networks can be arbitrarily large and complex, provided that predator-prey pairs are tightly coupled. The stability criteria are widely applicable, because they hold for any system of differential equations.

  11. General contamination criteria for optical surfaces. [instrument performance losses in spaceborne conditions

    NASA Technical Reports Server (NTRS)

    Bremer, J. C.

    1982-01-01

    Physical models are developed for establishing criteria to decide on the acceptable contamination level of optical devices in space-borne conditions. Optical systems can be degraded in terms of decreased throughput, i.e., transmissivity or reflectivity, or increases in the total integrated scatter (TIS). Performance losses can be caused by particulate accretion, molecular film accretion, and impact cratering. A quantitative relationship is defined for film thickness and loss of throughput. Formulas are also developed for cases where induced surface defects are larger than the desired viewing wavelengths, or smaller or of the same order of the observed wavelengths. The techniques are used to quantify the degradation of a VUV solar coronagraph, a VUV stellar telescope, and a solar cell due to TIS. Applications are projected for estimating the contamination sensitivity of specific instruments, assessing the contamination hazard from known particulates, or to define clean room standards.

  12. Defining Faculty Work.

    ERIC Educational Resources Information Center

    Gray, Peter J.; Diamond, Robert M.

    1994-01-01

    A process of planned change is proposed for redefining college faculty work. Legitimate faculty work is defined in broad terms, and information sources and methods for collecting information to support redefinition are identified. The final step in the redefinition process is the development of new mission statements for the institution and its…

  13. Defining Child Abuse.

    ERIC Educational Resources Information Center

    Giovannoni, Jeanne M.; Becerra, Rosina M.

    In seeking to clarify the meaning of the terms "child abuse" and "child neglect" it has been assumed that, like other forms of social deviance, they are socially defined phenomena. Interviews were conducted with those professionals (lawyers, pediatricians, police officers, and social workers) who daily handle the problems of abuse and neglect for…

  14. Defined by Limitations

    ERIC Educational Resources Information Center

    Arriola, Sonya; Murphy, Katy

    2010-01-01

    Undocumented students are a population defined by limitations. Their lack of legal residency and any supporting paperwork (e.g., Social Security number, government issued identification) renders them essentially invisible to the American and state governments. They cannot legally work. In many states, they cannot legally drive. After the age of…

  15. Defining Effective Teaching

    ERIC Educational Resources Information Center

    Layne, L.

    2012-01-01

    The author looks at the meaning of specific terminology commonly used in student surveys: "effective teaching." The research seeks to determine if there is a difference in how "effective teaching" is defined by those taking student surveys and those interpreting the results. To investigate this difference, a sample group of professors and students…

  16. Defining and Assessing Quality.

    ERIC Educational Resources Information Center

    Fincher, Cameron, Ed.

    The seven papers in this monograph focus on defining and assessing quality. The paper are: (1) "Reflections on Design Ideals" (E. Grady Bogue), which addresses some "governing ideals" of collegiate quality; (2) "Between a Rock and a Hard Place: Investment and Quality in Higher Education" (Sven Groennings), which sees the competitive quality of…

  17. On Defining Literacy.

    ERIC Educational Resources Information Center

    Sherritt, Caroline A.

    Defining literacy is a compelling challenge to educators. They generally use three models: instrumental, functional, and empowerment. The latter two approaches, which were increasingly evident in the 1980s, identify literacy by the social functions required in a given context or by the qualities needed for illiterate people to take control of…

  18. On Defining Mass

    ERIC Educational Resources Information Center

    Hecht, Eugene

    2011-01-01

    Though central to any pedagogical development of physics, the concept of mass is still not well understood. Properly defining mass has proven to be far more daunting than contemporary textbooks would have us believe. And yet today the origin of mass is one of the most aggressively pursued areas of research in all of physics. Much of the excitement…

  19. Defining Equality in Education

    ERIC Educational Resources Information Center

    Benson, Ronald E.

    1977-01-01

    Defines equality of education in three areas: 1) by the degree of integration of school systems; 2) by a comparison of material resources and assets in education; and 3) by the effects of schooling as measured by the mean scores of groups on standardized tests. Available from: College of Education, 107 Quadrangle, Iowa State University, Ames, Iowa…

  20. Project W-049H Collection System Acceptance Test

    SciTech Connect

    Buckles, D.I.

    1994-11-11

    The Acceptance Test Procedure (ATP) Program for Project W-049H covers the following activities: Disposal system, Collection system, Instrumentation and control system. Each activity has its own ATP. The purpose of the ATPs is to verify that the systems have been constructed in accordance with the construction documents and to demonstrate that the systems function as required by the Project criteria. This ATP has been prepared to demonstrate that the Collection System Instrumentation functions as required by project criteria.

  1. Fidelity Criteria: Development, Measurement, and Validation

    ERIC Educational Resources Information Center

    Mowbray, Carol T.; Holter, Mark C.; Teague, Gregory B.; Bybee, Deborah

    2003-01-01

    Fidelity may be defined as the extent to which delivery of an intervention adheres to the protocol or program model originally developed. Fidelity measurement has increasing significance for evaluation, treatment effectiveness research, and service administration. Yet few published studies using fidelity criteria provide details on the…

  2. Space shuttle program: Lightning protection criteria document

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The lightning environment for space shuttle design is defined and requirements that the design must satisfy to insure protection of the vehicle system from direct and indirect effects of lightning are imposed. Specifications, criteria, and guidelines included provide a practical and logical approach to protection problems.

  3. 42 CFR 505.5 - Loan criteria.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... meet the following criteria: (1) The hospital is located in a State that, based on population density, is defined as a rural State. A rural State is one of ten States with the lowest population density... prioritized beginning with the State with the lowest population density. Population density is...

  4. Acceptability of human risk.

    PubMed Central

    Kasperson, R E

    1983-01-01

    This paper has three objectives: to explore the nature of the problem implicit in the term "risk acceptability," to examine the possible contributions of scientific information to risk standard-setting, and to argue that societal response is best guided by considerations of process rather than formal methods of analysis. Most technological risks are not accepted but are imposed. There is also little reason to expect consensus among individuals on their tolerance of risk. Moreover, debates about risk levels are often at base debates over the adequacy of the institutions which manage the risks. Scientific information can contribute three broad types of analyses to risk-setting deliberations: contextual analysis, equity assessment, and public preference analysis. More effective risk-setting decisions will involve attention to the process used, particularly in regard to the requirements of procedural justice and democratic responsibility. PMID:6418541

  5. Defining early mycosis fungoides.

    PubMed

    Pimpinelli, Nicola; Olsen, Elise A; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L; Wood, Gary S

    2005-12-01

    This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.

  6. Fire protection design criteria

    SciTech Connect

    1997-03-01

    This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, national Fire Protection Association Codes and Standards, and any other applicable DOE construction criteria. This Standard, along with other delineated criteria, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

  7. UPDATE ON PEC ACTIVITIES INCLUDING NEW EVALUATION CRITERIA, THE APPLICATION COMPLETENESS CHECKLIST, AND STATUS OF THE WEBSITE DEVELOPMENT

    EPA Science Inventory

    US EPA's Pathogen Equivalency Committee (PEC) has updated the evaluation criteria it uses to make recommendations of equivalency (to processes acceptable under 40CFR503) on innovative or alternative sludge pathogen reduction processes. These criteria will be presented along with ...

  8. Age and Acceptance of Euthanasia.

    ERIC Educational Resources Information Center

    Ward, Russell A.

    1980-01-01

    Study explores relationship between age (and sex and race) and acceptance of euthanasia. Women and non-Whites were less accepting because of religiosity. Among older people less acceptance was attributable to their lesser education and greater religiosity. Results suggest that quality of life in old age affects acceptability of euthanasia. (Author)

  9. Recurrent Pregnancy Loss: Generally Accepted Causes and Their Management.

    PubMed

    Kaiser, Jennifer; Branch, D Ware

    2016-09-01

    Recurrent pregnancy loss (RPL), commonly defined as 3 consecutive losses <10 weeks gestation, affects up to 5% of couples. Well-accepted causes include uterine malformation, antiphospholipid syndrome, and parental chromosomal abnormalities; however, the majority of RPL cases are idiopathic (up to 75%). This chapter covers these accepted causes of RPL and provides diagnosis and management strategies for patients falling within the above categories.

  10. DOE natural phenomenal hazards design and evaluation criteria

    SciTech Connect

    Murray, R.C.; Nelson, T.A.; Short, S.A.; Kennedy, R.P.; Chander, H.; Hill, J.R.; Kimball, J.K.

    1994-10-01

    It is the policy of the Department of Energy (DOE) to design, construct, and operate DOE facilities so that workers, the general public, and the environment are protected from the impacts of natural phenomena hazards (NPH). Furthermore, DOE has established explicit goals of acceptable risk for NPH performance. As a result, natural phenomena hazard (earthquake, extreme wind, and flood) design and evaluation criteria for DOE facilities have been developed based on target probabilistic performance goals. These criteria include selection of design/evaluation NPH input from probabilistic hazard curves combined with commonly practiced deterministic response evaluation methods and acceptance criteria with controlled levels of conservatism. For earthquake considerations, conservatism is intentionally introduced in specification of material strengths and capacities, in the allowance of limited inelastic behavior, and by a seismic scale factor. Criteria have been developed following a graded approach for several performance goals ranging from that appropriate for normal-use facilities to that appropriate for facilities involving hazardous or critical operations. Performance goals are comprised of qualitative expressions of acceptable behavior and of target quantitative probabilities that acceptable limits of behavior are maintained. The criteria are simple procedures but have a rigorous basis. This paper addresses DOE seismic design and evaluation criteria.

  11. Defining Life: Synthesis and Conclusions

    NASA Astrophysics Data System (ADS)

    Gayon, Jean

    2010-04-01

    The first part of the paper offers philosophical landmarks on the general issue of defining life. §1 defends that the recognition of “life” has always been and remains primarily an intuitive process, for the scientist as for the layperson. However we should not expect, then, to be able to draw a definition from this original experience, because our cognitive apparatus has not been primarily designed for this. §2 is about definitions in general. Two kinds of definition should be carefully distinguished: lexical definitions (based upon current uses of a word), and stipulative or legislative definitions, which deliberately assign a meaning to a word, for the purpose of clarifying scientific or philosophical arguments. The present volume provides examples of these two kinds of definitions. §3 examines three traditional philosophical definitions of life, all of which have been elaborated prior to the emergence of biology as a specific scientific discipline: life as animation (Aristotle), life as mechanism, and life as organization (Kant). All three concepts constitute a common heritage that structures in depth a good deal of our cultural intuitions and vocabulary any time we try to think about “life”. The present volume offers examples of these three concepts in contemporary scientific discourse. The second part of the paper proposes a synthesis of the major debates developed in this volume. Three major questions have been discussed. A first issue (§4) is whether we should define life or not, and why. Most authors are skeptical about the possibility of defining life in a strong way, although all admit that criteria are useful in contexts such as exobiology, artificial life and the origins of life. §5 examines the possible kinds of definitions of life presented in the volume. Those authors who have explicitly defended that a definition of life is needed, can be classified into two categories. The first category (or standard view) refers to two conditions

  12. Defining life: synthesis and conclusions.

    PubMed

    Gayon, Jean

    2010-04-01

    The first part of the paper offers philosophical landmarks on the general issue of defining life. Section 1 defends that the recognition of "life" has always been and remains primarily an intuitive process, for the scientist as for the layperson. However we should not expect, then, to be able to draw a definition from this original experience, because our cognitive apparatus has not been primarily designed for this. Section 2 is about definitions in general. Two kinds of definition should be carefully distinguished: lexical definitions (based upon current uses of a word), and stipulative or legislative definitions, which deliberately assign a meaning to a word, for the purpose of clarifying scientific or philosophical arguments. The present volume provides examples of these two kinds of definitions. Section 3 examines three traditional philosophical definitions of life, all of which have been elaborated prior to the emergence of biology as a specific scientific discipline: life as animation (Aristotle), life as mechanism, and life as organization (Kant). All three concepts constitute a common heritage that structures in depth a good deal of our cultural intuitions and vocabulary any time we try to think about "life". The present volume offers examples of these three concepts in contemporary scientific discourse. The second part of the paper proposes a synthesis of the major debates developed in this volume. Three major questions have been discussed. A first issue (Section 4) is whether we should define life or not, and why. Most authors are skeptical about the possibility of defining life in a strong way, although all admit that criteria are useful in contexts such as exobiology, artificial life and the origins of life. Section 5 examines the possible kinds of definitions of life presented in the volume. Those authors who have explicitly defended that a definition of life is needed, can be classified into two categories. The first category (or standard view) refers

  13. Baby-Crying Acceptance

    NASA Astrophysics Data System (ADS)

    Martins, Tiago; de Magalhães, Sérgio Tenreiro

    The baby's crying is his most important mean of communication. The crying monitoring performed by devices that have been developed doesn't ensure the complete safety of the child. It is necessary to join, to these technological resources, means of communicating the results to the responsible, which would involve the digital processing of information available from crying. The survey carried out, enabled to understand the level of adoption, in the continental territory of Portugal, of a technology that will be able to do such a digital processing. It was used the TAM as the theoretical referential. The statistical analysis showed that there is a good probability of acceptance of such a system.

  14. High acceptance recoil polarimeter

    SciTech Connect

    The HARP Collaboration

    1992-12-05

    In order to detect neutrons and protons in the 50 to 600 MeV energy range and measure their polarization, an efficient, low-noise, self-calibrating device is being designed. This detector, known as the High Acceptance Recoil Polarimeter (HARP), is based on the recoil principle of proton detection from np[r arrow]n[prime]p[prime] or pp[r arrow]p[prime]p[prime] scattering (detected particles are underlined) which intrinsically yields polarization information on the incoming particle. HARP will be commissioned to carry out experiments in 1994.

  15. Design of a wavelength frame multiplication system using acceptance diagrams

    NASA Astrophysics Data System (ADS)

    Nekrassov, D.; Zendler, C.; Lieutenant, K.

    2013-07-01

    The concept of Wavelength Frame Multiplication (WFM) was developed to extend the usable wavelength range on long pulse neutron sources for instruments using pulse shaping choppers. For some instruments, it is combined with a pulse shaping double chopper, which defines a constant wavelength resolution, and a set of frame overlap choppers that prevent spurious neutrons from reaching the detector thus avoiding systematic errors in the calculation of wavelength from time of flight. Due to its complexity, the design of such a system is challenging and there are several criteria that need to be accounted for. In this work, the design of the WFM chopper system for a potential future liquids reflectometer at the European Spallation Source (ESS) is presented, which makes use of acceptance diagrams. They prove to be a powerful tool for understanding the work principle of the system and recognizing potential problems. The authors assume that the presented study can be useful for design or upgrade of further instruments, in particular the ones planned for the ESS.

  16. Defining periodontal health

    PubMed Central

    2015-01-01

    Assessment of the periodontium has relied exclusively on a variety of physical measurements (e.g., attachment level, probing depth, bone loss, mobility, recession, degree of inflammation, etc.) in relation to various case definitions of periodontal disease. Periodontal health was often an afterthought and was simply defined as the absence of the signs and symptoms of a periodontal disease. Accordingly, these strict and sometimes disparate definitions of periodontal disease have resulted in an idealistic requirement of a pristine periodontium for periodontal health, which makes us all diseased in one way or another. Furthermore, the consequence of not having a realistic definition of health has resulted in potentially questionable recommendations. The aim of this manuscript was to assess the biological, environmental, sociological, economic, educational and psychological relationships that are germane to constructing a paradigm that defines periodontal health using a modified wellness model. The paradigm includes four cardinal characteristics, i.e., 1) a functional dentition, 2) the painless function of a dentition, 3) the stability of the periodontal attachment apparatus, and 4) the psychological and social well-being of the individual. Finally, strategies and policies that advocate periodontal health were appraised. I'm not sick but I'm not well, and it's a sin to live so well. Flagpole Sitta, Harvey Danger PMID:26390888

  17. Defining quality of care: mission impossible?

    PubMed

    Reerink, E

    1990-01-01

    Finding the definition of quality has haunted mankind since the beginning of time. As far back as ancient Egypt and classical Greece, descriptions of quality show man's struggle with a concept that has not yet ended. Since the beginning of this century, descriptions of quality of health care have begun to take form in long lists of categories that make up the elements of quality. This catalog approach to defining quality has been replaced by the evaluative approach since Donabedian's conceptual studies in the 1960s. It has become commonplace now to define quality in evaluative terms: by comparing actual care with preset criteria, a judgement, and consequently a description or definition, can be obtained on real quality of care. In criteria and their derivatives one can document his intentions as to good quality; only after measurement and judgement can one be certain that quality has been described. A frequent source of concern is the erroneous belief that scientific research is synonymous with quality assessment. Research results form the basis of criteria for good care, and as such contribute to quality, but having obtained good research results does not imply that health care is properly and appropriately provided. PMID:1983237

  18. Death Acceptance through Ritual

    ERIC Educational Resources Information Center

    Reeves, Nancy C.

    2011-01-01

    This article summarizes the author's original research, which sought to discover the elements necessary for using death-related ritual as a psychotherapeutic technique for grieving people who experience their grief as "stuck," "unending," "maladaptive," and so on. A "death-related ritual" is defined as a ceremony, directly involving at least 1…

  19. Validation of analytical methods involved in dissolution assays: acceptance limits and decision methodologies.

    PubMed

    Rozet, E; Ziemons, E; Marini, R D; Boulanger, B; Hubert, Ph

    2012-11-01

    Dissolution tests are key elements to ensure continuing product quality and performance. The ultimate goal of these tests is to assure consistent product quality within a defined set of specification criteria. Validation of an analytical method aimed at assessing the dissolution profile of products or at verifying pharmacopoeias compliance should demonstrate that this analytical method is able to correctly declare two dissolution profiles as similar or drug products as compliant with respect to their specifications. It is essential to ensure that these analytical methods are fit for their purpose. Method validation is aimed at providing this guarantee. However, even in the ICHQ2 guideline there is no information explaining how to decide whether the method under validation is valid for its final purpose or not. Are the entire validation criterion needed to ensure that a Quality Control (QC) analytical method for dissolution test is valid? What acceptance limits should be set on these criteria? How to decide about method's validity? These are the questions that this work aims at answering. Focus is made to comply with the current implementation of the Quality by Design (QbD) principles in the pharmaceutical industry in order to allow to correctly defining the Analytical Target Profile (ATP) of analytical methods involved in dissolution tests. Analytical method validation is then the natural demonstration that the developed methods are fit for their intended purpose and is not any more the inconsiderate checklist validation approach still generally performed to complete the filing required to obtain product marketing authorization. PMID:23084050

  20. Criteria for Describing and Assessing Competency Based Programs.

    ERIC Educational Resources Information Center

    Burke, J. Bruce; And Others

    This monograph contains a set of criteria to be used in helping program planners and administrators define competency based teacher education (CBTE) in the contexts of their situations. The criteria are the result of the collective work of individuals at 12 institutions of teacher education, and have been used: (1) by individuals in operational…

  1. Functional Literacy in Schoolchildren. Definition and Criteria of Test Selection.

    ERIC Educational Resources Information Center

    Bessemer, David W.; Spencer, Mary L.

    As part of the development of a functional literacy test for fourth through eigth grade children in Title I compensatory education programs, this report defines functional literacy for children and enumerates criteria for evaluating existing tests. Criteria for selection of a test include: (1) content, empirical, and construct validity; (2)…

  2. Criteria for High Quality Biology Teaching: An Analysis

    ERIC Educational Resources Information Center

    Tasci, Guntay

    2015-01-01

    This study aims to analyze the process under which biology lessons are taught in terms of teaching quality criteria (TQC). Teaching quality is defined as the properties of efficient teaching and is considered to be the criteria used to measure teaching quality both in general and specific to a field. The data were collected through classroom…

  3. 16 CFR 1616.4 - Sampling and acceptance procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Sampling and acceptance procedures. (a) General. (1) The test criteria of § 1616.3(b) shall be used in..., Fabric sampling or, for verification purposes, from randomly selected garments. (8) Multi-layer fabrics... length. Garments manufactured from multi-layer fabrics shall be tested with the edge finish which is...

  4. Acceptance test report, plutonium finishing plant life safety upgrade

    SciTech Connect

    Hodge, S.G.

    1994-12-02

    This acceptance Test Procedure (ATP) has been prepared to demonstrate that modifications to the Fir Protection systems function as required by project criteria. The ATP will test the Fire Alarm Control Panels, Flow Alarm Pressure Switch, Heat Detectors, Smoke Detectors, Flow Switches, Manual Pull Stations, and Gong/Door By Pass Switches.

  5. TAPERED DEFINING SLOT

    DOEpatents

    Pressey, F.W.

    1959-09-01

    An improvement is reported in the shape and formation of the slot or opening in the collimating slot member which forms part of an ion source of the type wherein a vapor of the material to be ionized is bombarded by electrons in a magnetic field to strike an arc-producing ionization. The defining slot is formed so as to have a substantial taper away from the cathode, causing the electron bombardment from the cathode to be dispersed over a greater area reducing its temperature and at the same time bringing the principal concentration of heat from the electron bombardment nearer the anode side of the slot, thus reducing deterioration and prolonging the life of the slot member during operation.

  6. Defining the mobilome.

    PubMed

    Siefert, Janet L

    2009-01-01

    This chapter defines the agents that provide for the movement of genetic material which fuels the adaptive potential of life on our planet. The chapter has been structured to be broadly comprehensive, arbitrarily categorizing the mobilome into four classes: (1) transposons, (2) plasmids, (3) bacteriophage, and (4) self-splicing molecular parasites.Our increasing understanding of the mobilome is as dynamic as the mobilome itself. With continuing discovery, it is clear that nature has not confined these genomic agents of change to neat categories, but rather the classification categories overlap and intertwine. Massive sequencing efforts and their published analyses are continuing to refine our understanding of the extent of the mobilome. This chapter provides a framework to describe our current understanding of the mobilome and a foundation on which appreciation of its impact on genome evolution can be understood.

  7. Defining critical thoughts.

    PubMed

    Lovatt, Abbie

    2014-05-01

    Nursing education has long struggled to define critical thinking and explain how the process of critical thinking fits into the context of nursing. Despite this long time struggle, nurses and nurse educators continue to strive to foster critical thinking skills in nursing students as intuitively most nurses believe that critical thinking is necessary to function competently in the workplace. This article explores the most recent work of Dr. Stephen Brookfield and ties the concepts which are explored in Brookfield's work to nursing practice. Brookfield identifies that learners understand the meaning of critical thinking the best when the process is first demonstrated. Role modeling is a method educators can use to demonstrate critical thinking and is a strategy which nurses often use in the clinical area to train and mentor new nursing staff. Although it is not a new strategy in nursing education, it is a valuable strategy to engage learners in critical thinking activities. PMID:24418065

  8. Proliferation resistance criteria for fissile material disposition

    SciTech Connect

    Close, D.A.; Fearey, B.L.; Markin, J.T.; Rutherford, D.A.; Duggan, R.A.; Jaeger, C.D.; Mangan, D.L.; Moya, R.W.; Moore, L.R.; Strait, R.S.

    1995-04-01

    The 1994 National Academy of Sciences study {open_quotes}Management and Disposition of Excess Weapons Plutonium{close_quotes} defined options for reducing the national and international proliferation risks of materials declared excess to the nuclear weapons program. This report proposes criteria for assessing the proliferation resistance of these options. The criteria are general, encompassing all stages of the disposition process from storage through intermediate processing to final disposition including the facilities, processing technologies and materials, the level of safeguards for these materials, and the national/subnational threat to the materials.

  9. Study of helicopterroll control effectiveness criteria

    NASA Technical Reports Server (NTRS)

    Heffley, Robert K.; Bourne, Simon M.; Curtiss, Howard C., Jr.; Hindson, William S.; Hess, Ronald A.

    1986-01-01

    A study of helicopter roll control effectiveness based on closed-loop task performance measurement and modeling is presented. Roll control critieria are based on task margin, the excess of vehicle task performance capability over the pilot's task performance demand. Appropriate helicopter roll axis dynamic models are defined for use with analytic models for task performance. Both near-earth and up-and-away large-amplitude maneuvering phases are considered. The results of in-flight and moving-base simulation measurements are presented to support the roll control effectiveness criteria offered. This Volume contains the theoretical analysis, simulation results and criteria development.

  10. [Criteria for determining the adaptation of children to studying loads].

    PubMed

    Potupchik, T V; Makarova, M V; Prakhin, E I; Evert, L S; Baksheeva, S S

    2011-01-01

    Three hundred and two Krasnoyarsk gymnasium students were examined to define criteria for determining the adaptation to high schooling loads. The values of the emotional status and adaptive processes were studied in children with varying resistance and varying mastering capacities; the impact of cardiovascular parameters on their adaptive process was defined The criteria for estimating the adaptation to high schooling loads were the presence or absence of acute chills and neurotic reactions, cardiovascular performance, and psychoemotional status. PMID:22250390

  11. Sediment quality criteria: A review with recommendations for developing criteria for the Hanford Site

    SciTech Connect

    Driver, C.J.

    1994-05-01

    Criteria for determining the quality of liver sediment are necessary to ensure that concentrations of contaminants in aquatic systems are within acceptable limits for the protection of aquatic and human life. Such criteria should facilitate decision-making about remediation, handling, and disposal of contaminants. Several approaches to the development of sediment quality criteria (SQC) have been described and include both descriptive and numerical methods. However, no single method measures all impacts at all times to all organisms (U.S. EPA 1992b). The U.S. EPA`s interest is primarily in establishing chemically based, numerical SQC that are applicable nation-wide (Shea 1988). Of the approaches proposed for SQC development, only three are being considered for numerical SQC on a national level. These approaches include an Equilibrium Partitioning Approach, a site-specific method using bioassays (the Apparent Effects Threshold Approach), and an approach similar to EPA`s water quality criteria (Pavlou and Weston 1984). Although national (or even regional) criteria address a number of political, litigative, and engineering needs, some researchers feel that protection of benthic communities require site-specific, biologically based criteria (Baudo et al. 1990). This is particularly true for areas where complex mixtures of contaminants are present in sediments. Other scientifically valid and accepted procedures for freshwater SQC include a background concentration approach, methods using field or spiked bioassays, a screening level concentration approach, the Apparent Effects Threshold Approach, the Sediment Quality Triad, the International Joint Commission Sediment Assessment Strategy, and the National Status and Trends Program Approach. The various sediment assessment approaches are evaluated for application to the Hanford Reach and recommendations for Hanford Site sediment quality criteria are discussed.

  12. Myoepithelioma: definitions and diagnostic criteria.

    PubMed

    Dardick, I

    1995-01-01

    Due to their infrequency and multiplicity of histopathology, myoepitheliomas present difficulties in diagnosis and classification. Cellular varieties can be misdiagnosed as malignancies. Improvements in and clarification of diagnostic criteria are, therefore, required. A key to determining diagnostic criteria for myoepitheliomas is to study cellular morphology, cytoplasmic filament expression, and ultrastructural features of the nonluminal, i.e., neoplastic myoepithelial/basal, tumor cells of pleomorphic adenomas, and apply this information to defining myoepitheliomas. Cytologic and growth patterns of nonluminal cells in pleomorphic adenomas, including plasma-cytoid cells, are reflected in myoepitheliomas. Results also indicate that muscle-specific actin and myofilaments are expressed only in a proportion of cases, and generally in not more than 60-70% of nonluminal cells in pleomorphic adenoma; this also applies to benign and malignant myoepitheliomas. The absence of these markers does not exclude a diagnosis of myoepithelioma. Vimentin and glial acidic fibrillary protein, however, are strongly and diffusely expressed in the majority of pleomorphic adenomas and myoepitheliomas and are more reliable markers for these tumors than muscle-specific actin. Like so many other salivary gland tumors, myoepitheliomas present an equally complex histomorphology and variable expression of antigenic markers, only some of which are associated with myoepithelial and basal cells of the acini and ducts of the normal salivary gland.

  13. Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

    PubMed

    Schiffelers, Marie-Jeanne W A; Blaauboer, Bas J; Bakker, Wieger E; Beken, Sonja; Hendriksen, Coenraad F M; Koëter, Herman B W M; Krul, Cyrille

    2014-06-01

    Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Reduce or Refine the animal models. However, these models must overcome many barriers before being accepted for regulatory risk management purposes. This paper describes the barriers and drivers and options to optimize this acceptance process as identified by two expert panels, one on pharmaceuticals and one on chemicals. To untangle the complex acceptance process, the multilevel perspective on technology transitions is applied. This perspective defines influences at the micro-, meso- and macro level which need alignment to induce regulatory acceptance of a 3R model. This paper displays that there are many similar mechanisms within both sectors that prevent 3R models from becoming accepted for regulatory risk assessment and management. Shared barriers include the uncertainty about the value of the new 3R models (micro level), the lack of harmonization of regulatory requirements and acceptance criteria (meso level) and the high levels of risk aversion (macro level). In optimizing the process commitment, communication, cooperation and coordination are identified as critical drivers.

  14. NWTS program criteria for mined geologic disposal of nuclear waste: program objectives, functional requirements, and system performance criteria

    SciTech Connect

    1981-04-01

    At the present time, final repository criteria have not been issued by the responsible agencies. This document describes general objectives, requirements, and criteria that the DOE intends to apply in the interim to the National Waste Terminal Storage (NWTS) Program. These objectives, requirements, and criteria have been developed on the basis of DOE's analysis of what is needed to achieve the National objective of safe waste disposal in an environmentally acceptable and economic manner and are expected to be consistent with anticipated regulatory standards. The qualitative statements in this document address the broad issues of public and occupational health and safety, institutional acceptability, engineering feasibility, and economic considerations. A comprehensive set of criteria, general and project specific, of which these are a part, will constitute a portion of the technical basis for preparation and submittal by the DOE of formal documents to support future license applications for nuclear waste repositories.

  15. Laboratory Equipment Criteria.

    ERIC Educational Resources Information Center

    State Univ. Construction Fund, Albany, NY.

    Requirements for planning, designing, constructing and installing laboratory furniture are given in conjunction with establishing facility criteria for housing laboratory equipment. Furniture and equipment described include--(1) center tables, (2) reagent racks, (3) laboratory benches and their mechanical fixtures, (4) sink and work counters, (5)…

  16. Defining an emerging disease.

    PubMed

    Moutou, F; Pastoret, P-P

    2015-04-01

    Defining an emerging disease is not straightforward, as there are several different types of disease emergence. For example, there can be a 'real' emergence of a brand new disease, such as the emergence of bovine spongiform encephalopathy in the 1980s, or a geographic emergence in an area not previously affected, such as the emergence of bluetongue in northern Europe in 2006. In addition, disease can emerge in species formerly not considered affected, e.g. the emergence of bovine tuberculosis in wildlife species since 2000 in France. There can also be an unexpected increase of disease incidence in a known area and a known species, or there may simply be an increase in our knowledge or awareness of a particular disease. What all these emerging diseases have in common is that human activity frequently has a role to play in their emergence. For example, bovine spongiform encephalopathy very probably emerged as a result of changes in the manufacturing of meat-and-bone meal, bluetongue was able to spread to cooler climes as a result of uncontrolled trade in animals, and a relaxation of screening and surveillance for bovine tuberculosis enabled the disease to re-emerge in areas that had been able to drastically reduce the number of cases. Globalisation and population growth will continue to affect the epidemiology of diseases in years to come and ecosystems will continue to evolve. Furthermore, new technologies such as metagenomics and high-throughput sequencing are identifying new microorganisms all the time. Change is the one constant, and diseases will continue to emerge, and we must consider the causes and different types of emergence as we deal with these diseases in the future. PMID:26470448

  17. Defining an emerging disease.

    PubMed

    Moutou, F; Pastoret, P-P

    2015-04-01

    Defining an emerging disease is not straightforward, as there are several different types of disease emergence. For example, there can be a 'real' emergence of a brand new disease, such as the emergence of bovine spongiform encephalopathy in the 1980s, or a geographic emergence in an area not previously affected, such as the emergence of bluetongue in northern Europe in 2006. In addition, disease can emerge in species formerly not considered affected, e.g. the emergence of bovine tuberculosis in wildlife species since 2000 in France. There can also be an unexpected increase of disease incidence in a known area and a known species, or there may simply be an increase in our knowledge or awareness of a particular disease. What all these emerging diseases have in common is that human activity frequently has a role to play in their emergence. For example, bovine spongiform encephalopathy very probably emerged as a result of changes in the manufacturing of meat-and-bone meal, bluetongue was able to spread to cooler climes as a result of uncontrolled trade in animals, and a relaxation of screening and surveillance for bovine tuberculosis enabled the disease to re-emerge in areas that had been able to drastically reduce the number of cases. Globalisation and population growth will continue to affect the epidemiology of diseases in years to come and ecosystems will continue to evolve. Furthermore, new technologies such as metagenomics and high-throughput sequencing are identifying new microorganisms all the time. Change is the one constant, and diseases will continue to emerge, and we must consider the causes and different types of emergence as we deal with these diseases in the future.

  18. Conflict in the parameters defining life and death in Missouri statutes.

    PubMed

    Schoen, W L

    1990-01-01

    Over the last twenty years, state legislatures have enacted statutes incorporating medically and legally established criteria to be utilized in the determination of death. Similarly consistent criteria for determining the onset of life have yet to be established. As a result, unacceptably conflicting statutory language defining life and the state's interest in that life exists. This conflict can be resolved by a functional approach that consistently applies criteria used to define the end of life to the beginning of life.

  19. [Medical criteria of delaying or stopping imprisonment].

    PubMed

    Engelgardt, Piotr; Sliwka, Karol

    2006-01-01

    Estimating the subject's ability to undergo imprisonment and determining whether there are any reasons for delaying or stopping imprisonment, has become a serious problem. Currently the Polish system lacks clear and homogenous opinionating criteria, and the available sources provide only general guidelines. This results in a great deal of discrepancy between opinions and evaluations made in similar cases. This work attempts to define and illustrate the criteria of the Executive Penal Code that are used in evaluating whether imprisonment is to be delayed or stopped. The authors have also provided examples of illnesses that would illustrate those definitions/criteria and came up with a suggested procedure of decision-making to be applied to such cases.

  20. Noise and vibration ride comfort criteria

    NASA Technical Reports Server (NTRS)

    Dempsey, T. K.; Leatherwood, J. D.; Clevenson, S. A.

    1976-01-01

    Two of the most important factors, namely, vibration and noise, were studied to (1) determine whether composite or separate noise and vibration criteria are needed for the prediction of ride quality, (2) determine a noise correction for the previously-defined vibration criteria of the ride quality model, (3) assess whether these noise corrections depend on the nature of the vibration stimuli, i.e., deterministic as opposed to random, and (4) specify noise-vibration criteria for this combined environment. The stimuli for the study consisted of octave bands of noise centered at 500 or 2,000 Hz and vertical vibrations composed of either 5 Hz sinusoidal vibration or random vibrations centered at 5 Hz and with a 5 Hz bandwidth. The noise stimuli were presented at levels ranging from ambient to 95 dB(A) and the vibrations at levels ranging from 0.02 to 0.13g rms.

  1. NASA Lewis Wind Tunnel Model Systems Criteria

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.; Haller, Henry C.

    1994-01-01

    This report describes criteria for the design, analysis, quality assurance, and documentation of models or test articles that are to be tested in the aeropropulsion facilities at the NASA Lewis Research Center. The report presents three methods for computing model allowable stresses on the basis of the yield stress or ultimate stress, and it gives quality assurance criteria for models tested in Lewis' aeropropulsion facilities. Both customer-furnished model systems and in-house model systems are discussed. The functions of the facility manager, project engineer, operations engineer, research engineer, and facility electrical engineer are defined. The format for pretest meetings, prerun safety meetings, and the model criteria review are outlined Then, the format for the model systems report (a requirement for each model that is to be tested at NASA Lewis) is described, the engineers that are responsible for developing the model systems report are listed, and the time table for its delivery to the facility manager is given.

  2. Gender weighting of DSM-III-R personality disorder criteria.

    PubMed

    Sprock, J; Blashfield, R K; Smith, B

    1990-05-01

    This study explored the gender weighting of the diagnostic criteria for personality disorders. Gender weighting was defined in terms of how 33 female and 17 male nonclinicians ranked the diagnostic criteria along a male-female dimension. Although the a priori expectation was that antisocial would be the prototypically masculine personality disorder and histrionic the feminine, the subjects ranked criteria from the sadistic category as the most masculine and those from the dependent category as the most feminine. These results and the subjects' gender weighting of criteria for borderline, obsessive-compulsive, and self-defeating personality disorders are analyzed in detail.

  3. Sonic boom acceptability studies

    NASA Astrophysics Data System (ADS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; McCurdy, David A.

    1992-04-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  4. Sonic boom acceptability studies

    NASA Technical Reports Server (NTRS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; Mccurdy, David A.

    1992-01-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  5. Criteria for the evaluation and certification of long-term digital archives in the earth sciences

    NASA Astrophysics Data System (ADS)

    Klump, Jens

    2010-05-01

    Digital information has become an indispensable part of our cultural and scientific heritage. Scientific findings, historical documents and cultural achievements are to a rapidly increasing extent being presented in electronic form - in many cases exclusively so. However, besides the invaluable advantages offered by this form, it also carries a serious disadvantage: users need to invest a great deal of technical effort in accessing the information. Also, the underlying technology is still undergoing further development at an exceptionally fast pace. The rapid obsolescence of the technology required to read the information combined with the frequently imperceptible physical decay of the media themselves represents a serious threat to preservation of the information content. Many data sets in earth science research are from observations that cannot be repeated. This makes these digital assets particularly valuable. Therefore, these data should be kept and made available for re-use long after the end of the project from which they originated. Since research projects only run for a relatively short period of time, it is advisable to shift the burden of responsibility for long-term data curation from the individual researcher to a trusted data repository or archive. But what makes a trusted data repository? Each trusted digital repository has its own targets and specifications. The trustworthiness of digital repositories can be tested and assessed on the basis of a criteria catalogue. This is the main focus of the work of the nestor working group "Trusted repositories - Certification". It identifies criteria which permit the trustworthiness of a digital repository to be evaluated, both at the organisational and technical levels. The criteria are defined in close collaboration with a wide range of different memory organisations, producers of information, experts and other interested parties. This open approach ensures a high degree of universal validity, suitability for

  6. Quality criteria for electronic publications in medicine.

    PubMed

    Schulz, S; Auhuber, T; Schrader, U; Klar, R

    1998-01-01

    This paper defines "electronic publications in medicine (EPM)" as computer based training programs, databases, knowledge-based systems, multimedia applications and electronic books running on standard platforms and available by usual distribution channels. A detailed catalogue of quality criteria as a basis for development and evaluation of EPMs is presented. The necessity to raise the quality level of electronic publications is stressed considering aspects of domain knowledge, software engineering, media development, interface design and didactics.

  7. Design criteria for Reedy Creek Demonstration Project

    SciTech Connect

    Felicione, F.S.; Logan, J.A.

    1980-11-01

    This document defines the basic criteria for the 100-ton/day pilot plant which will use the Andco-Torrax pyrolysis process at Walt Disney World in Orlando, Florida, to produce hot water. The waste will simulate transuranic wastes which are stored at INEL. The Andco-Torrax process is designed to convert mixed municipal refuse into energy and is called slagging pyrolysis solid waste conversion. (DLC)

  8. Performance criteria for dosimeter angular response

    SciTech Connect

    Roberson, P.L.; Fox, R. A.; Cummings, F. M.; McDonald, J. C.; Jones, K.L.

    1988-06-01

    This report provides criteria for evaluating the response of personnel dosimeters to radiation at nonperpendicular incidence. The US Department of Energy Laboratory Accreditation Program (DOELAP) ensures that dosimetry systems at DOE facilities meet acceptable standards for precision and accuracy. In the past, these standards were limited to tests for system variability, energy dependence, and level of detection. The proposed criteria will broaden the scope of DOELAP to include the angular response of personnel dosimeters. Because occupational exposures in the workplace are rarely due to radiation from only one direction, dosimeters must accurately assign individual dose equivalent from irradiation at any forward angle of incidence. Including an angular response criterion in DOELAP would improve the quality of personnel monitoring provided that the criterion is developed from appropriate dose quantities. This report provides guidance for assigning individual dose equivalents for radiation fields at nonperpendicular incidence to the dosimeter. 21 refs., 10 figs., 10 tabs.

  9. Composting process design criteria. II. Detention time

    SciTech Connect

    Haug, R.T.

    1986-09-01

    Attention has always been directed to detention time as a criteria for design and operation of composting systems. Perhaps this is a logical outgrowth of work on liquid phase systems, where detention time is a fundamental parameter of design. Unlike liquid phase systems, however, the interpretation of detention time and actual values required for design have not been universally accepted in the case of composting. As a case in point, most compost systems incorporate facilities for curing the compost product. However, curing often is considered after the fact or as an add on with little relationship to the first stage, high-rate phase, whether reactor (in-vessel), static pile, or windrow. Design criteria for curing and the relationships between the first-stage, high-rate and second-stage, curing phases of a composting system have been unclear. In Part 2 of this paper, the concepts of hydraulic retention time (HRT) and solids residence time (SRT) are applied to the composting process. Definitions and design criteria for each are proposed. Based on these criteria, the first and second-stages can be designed and integrated into a complete composting system.

  10. Unified nonclassicality criteria

    NASA Astrophysics Data System (ADS)

    Ryl, S.; Sperling, J.; Agudelo, E.; Mraz, M.; Köhnke, S.; Hage, B.; Vogel, W.

    2015-07-01

    In this work we generalize the Bochner criterion addressing the characteristic function, i.e., the Fourier transform, of the Glauber-Sudarshan phase-space function. For this purpose we extend the Bochner theorem by including derivatives of the characteristic function. The resulting necessary and sufficient nonclassicality criteria unify previously known moment-based criteria with those based on the characteristic function. For applications of the generalized nonclassicality probes, we provide direct sampling formulas for balanced homodyne detection. A squeezed vacuum state is experimentally realized and characterized with our method. This complete framework—theoretical unification, sampling approach, and experimental implementation—presents an efficient toolbox to characterize quantum states of light for applications in quantum technology.

  11. Space Tethers: Design Criteria

    NASA Technical Reports Server (NTRS)

    Tomlin, D. D.; Faile, G. C.; Hayashida, K. B.; Frost, C. L.; Wagner, C. Y.; Mitchell, M. L.; Vaughn, J. A.; Galuska, M. J.

    1997-01-01

    This document is prepared to provide a systematic process for the selection of tethers for space applications. Criteria arc provided for determining the strength requirement for tether missions and for mission success from tether severing due to micrometeoroids and orbital debris particle impacts. Background information of materials for use in space tethers is provided, including electricity-conducting tethers. Dynamic considerations for tether selection is also provided. Safety, quality, and reliability considerations are provided for a tether project.

  12. PML diagnostic criteria

    PubMed Central

    Aksamit, Allen J.; Clifford, David B.; Davis, Larry; Koralnik, Igor J.; Sejvar, James J.; Bartt, Russell; Major, Eugene O.; Nath, Avindra

    2013-01-01

    Objective: To establish criteria for the diagnosis of progressive multifocal leukoencephalopathy (PML). Methods: We reviewed available literature to identify various diagnostic criteria employed. Several search strategies employing the terms “progressive multifocal leukoencephalopathy” with or without “JC virus” were performed with PubMed, SCOPUS, and EMBASE search engines. The articles were reviewed by a committee of individuals with expertise in the disorder in order to determine the most useful applicable criteria. Results: A consensus statement was developed employing clinical, imaging, pathologic, and virologic evidence in support of the diagnosis of PML. Two separate pathways, histopathologic and clinical, for PML diagnosis are proposed. Diagnostic classification includes certain, probable, possible, and not PML. Conclusion: Definitive diagnosis of PML requires neuropathologic demonstration of the typical histopathologic triad (demyelination, bizarre astrocytes, and enlarged oligodendroglial nuclei) coupled with the techniques to show the presence of JC virus. The presence of clinical and imaging manifestations consistent with the diagnosis and not better explained by other disorders coupled with the demonstration of JC virus by PCR in CSF is also considered diagnostic. Algorithms for establishing the diagnosis have been recommended. PMID:23568998

  13. Developing a formal representation for medication appropriateness criteria.

    PubMed

    Salmasian, Hojjat; Tran, Tran H; Friedman, Carol

    2014-01-01

    Inappropriate medications use (IMU) is a serious issue of global concern that leads to a waste of resources and potentially harms the patients. IMU can usually be identified by extracting information about the patient's conditions and treatments, and comparing them with "medication appropriateness criteria". To enable automation of these criteria, we developed a formal representation for them, which we called Objective Medication Appropriateness Criteria (OMAC). OMAC represents four aspects of the criteria: trigger, rules, action and metadata. Our evaluation showed that OMAC can completely represent explicitly defined medication appropriateness criteria using links to external knowledge sources. OMAC is the first formal representation for medication appropriateness criteria, and will enable development of structured rules for appropriate use of medications that can be implemented using standards for clinical decision support.

  14. Wall thinning criteria for low temperature-low pressure piping

    SciTech Connect

    Mertz, G.E.

    1993-01-01

    This acceptance criteria is intended to prevent gross rupture or rapidly propagating failure during normal and abnormal operating conditions. Pitting may be present in the carbon steel piping. While the acceptance criteria have provisions to preclude gross rupture through a pitted region, they do not protect against throughwall pit growth and subsequent leakage. Potential leakage through a pit in low pressure piping is less than the post-DBE design basis leakage. Both the uniform thinning and LTA criteria protect against leakage, since their potential for leakage is larger. The acceptance criteria protects against gross rupture due to general wall thinning, local wall thinning (LTA's), pitting, and fracture through weld defects. General wall thinning calculations are based on the restart criteria, SEP-24. LTA criteria for hoop stresses are based on ASME Code Case N-480 [open quotes]Examination Requirements for Pipe Wall Thinning Due to Single Phase Erosion and Corrosion[close quotes]. The LTA criteria for axial stress is based on an effective average thickness concept, which prevents plastic collapse of a locally thinned pipe. Limits on pit density, based on an effective cross section concept, are used to prevent gross rupture through a group of pits. The CEGB R-6 failure assessment diagram is used in the fracture evaluation, along with postulated weld defects. This criteria is intended for low temperature, low pressure piping systems. Corrosion and/or weld defects increase the peak stresses during normal operation and may lead to a reduction in fatigue life. Piping systems subject to significant thermal or mechanical fatigue will require additional analysis which is beyond the scope of this document.

  15. First policy then science: why a management unit based solely on genetic criteria cannot work.

    PubMed

    Taylor, B L; Dizon, A E

    1999-12-01

    In contrast to the goals of the symposium from which this series of papers originated, we argue that attempts to apply unambiguously defined and general management unit criteria based solely on genetic parameters can easily lead to incorrect management decisions. We maintain that conservation genetics is best served by altering the perspective of data analysis so that decision making is optimally facilitated. To do so requires accounting for policy objectives early in the design and execution of the science. This contrasts with typical hypothesis testing approaches to analysing genetic data for determining population structure, which often aspire to objectivity by considering management objectives only after the analysis is complete. The null hypothesis is generally taken as panmixia with a strong predilection towards avoiding false acceptance of the alternative hypothesis (the existence of population structure). We show by example how defining management units using genetic data and standard scientific analyses that do not consider either the specific management objectives or the anthropogenic risks facing the populations being studied can easily result in a management failure by losing local populations. We then use the same example to show how an 'applied' approach driven by specific objectives and knowledge of abundance and mortality results in appropriate analyses and better decisions. Because management objectives stem from public policy, which differs among countries and among species groups, criteria for defining management units must be specific, not general. Therefore, we conclude that the most productive way to define management units is on a case-by-case basis. We also suggest that creating analytical tools designed specifically to address decision making in a management context, rather than re-tooling academic tools designed for other purposes, will increase and improve the use of genetics in conservation.

  16. Enhancing reuse of structured eligibility criteria and supporting their relaxation.

    PubMed

    Milian, Krystyna; Hoekstra, Rinke; Bucur, Anca; Ten Teije, Annette; van Harmelen, Frank; Paulissen, John

    2015-08-01

    Patient recruitment is one of the most important barriers to successful completion of clinical trials and thus to obtaining evidence about new methods for prevention, diagnostics and treatment. The reason is that recruitment is effort consuming. It requires the identification of candidate patients for the trial (the population under study), and verifying for each patient whether the eligibility criteria are met. The work we describe in this paper aims to support the comparison of population under study in different trials, and the design of eligibility criteria for new trials. We do this by introducing structured eligibility criteria, that enhance reuse of criteria across trials. We developed a method that allows for automated structuring of criteria from text. Additionally, structured eligibility criteria allow us to propose suggestions for relaxation of criteria to remove potentially unnecessarily restrictive conditions. We thereby increase the recruitment potential and generalizability of a trial. Our method for automated structuring of criteria enables us to identify related conditions and to compare their restrictiveness. The comparison is based on the general meaning of criteria, comprised of commonly occurring contextual patterns, medical concepts and constraining values. These are automatically identified using our pattern detection algorithm, state of the art ontology annotators and semantic taggers. The comparison uses predefined relations between the patterns, concept equivalences defined in medical ontologies, and threshold values. The result is a library of structured eligibility criteria which can be browsed using fine grained queries. Furthermore, we developed visualizations for the library that enable intuitive navigation of relations between trials, criteria and concepts. These visualizations expose interesting co-occurrences and correlations, potentially enhancing meta-research. The method for criteria structuring processes only certain types of

  17. Tolerance, Acceptance and the Virtue of Orthonomy: A Reply to Lawrence Blum and Brenda Almond

    ERIC Educational Resources Information Center

    Ciurria, Michelle

    2011-01-01

    In the "Journal of Moral Education," 39(2), Brenda Almond and Lawrence Blum debate the importance of tolerance versus acceptance in sex education. Blum defines acceptance as "positive regard", in contradistinction to mere tolerance, "a live and let live attitude toward others, an acceptance of coexistence, but with a disapproval of that "other"".…

  18. Magnetic criteria of aromaticity.

    PubMed

    Gershoni-Poranne, Renana; Stanger, Amnon

    2015-09-21

    This review describes the current state of magnetic criteria of aromaticity. The introduction contains the fundamentals of ring currents in aromatic and antiaromatic systems, followed by a brief description of experimental and computational tools: NMR, diamagnetic susceptibility exaltation, current density analyses (CDA) and nucleus independent chemical shifts (NICS). This is followed by more comprehensive chapters: NMR - focusing on the work of R. Mitchell - NICS and CDA - describing the progress and development of the methods to their current state and presenting some examples of representative work. PMID:26035305

  19. Magnetic criteria of aromaticity.

    PubMed

    Gershoni-Poranne, Renana; Stanger, Amnon

    2015-09-21

    This review describes the current state of magnetic criteria of aromaticity. The introduction contains the fundamentals of ring currents in aromatic and antiaromatic systems, followed by a brief description of experimental and computational tools: NMR, diamagnetic susceptibility exaltation, current density analyses (CDA) and nucleus independent chemical shifts (NICS). This is followed by more comprehensive chapters: NMR - focusing on the work of R. Mitchell - NICS and CDA - describing the progress and development of the methods to their current state and presenting some examples of representative work.

  20. Cone penetrometer acceptance test report

    SciTech Connect

    Boechler, G.N.

    1996-09-19

    This Acceptance Test Report (ATR) documents the results of acceptance test procedure WHC-SD-WM-ATR-151. Included in this report is a summary of the tests, the results and issues, the signature and sign- off ATP pages, and a summarized table of the specification vs. ATP section that satisfied the specification.

  1. Financial Aid for Self-Supporting Students: Defining Independence.

    ERIC Educational Resources Information Center

    Wagner, Alan P.; Carlson, Nancy

    Current federal definitions and proposed alternative definitions of financially independent students, and the effect of the definitions on the numbers and attributes of independent students, are reviewed. Current federal law defines financial aid applicants as financially independent of their parents if they meet three criteria (the "tri-form"…

  2. Performance Criteria and Evaluation System

    1992-06-18

    The Performance Criteria and Evaluation System (PCES) was developed in order to make a data base of criteria accessible to radiation safety staff. The criteria included in the package are applicable to occupational radiation safety at DOE reactor and nonreactor nuclear facilities, but any data base of criteria may be created using the Criterion Data Base Utiliity (CDU). PCES assists personnel in carrying out oversight, line, and support activities.

  3. Dissolution test acceptance sampling plans.

    PubMed

    Tsong, Y; Hammerstrom, T; Lin, K; Ong, T E

    1995-07-01

    The U.S. Pharmacopeia (USP) general monograph provides a standard for dissolution compliance with the requirements as stated in the individual USP monograph for a tablet or capsule dosage form. The acceptance rules recommended by USP have important roles in the quality control process. The USP rules and their modifications are often used as an industrial lot release sampling plan, where a lot is accepted when the tablets or capsules sampled are accepted as proof of compliance with the requirement. In this paper, the operating characteristics of the USP acceptance rules are reviewed and compared to a selected modification. The operating characteristics curves show that the USP acceptance rules are sensitive to the true mean dissolution and do not reject a lot or batch that has a large percentage of tablets that dissolve with less than the dissolution specification.

  4. Expanded criteria donors.

    PubMed

    Feng, Sandy; Lai, Jennifer C

    2014-08-01

    The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advancing donor age, donation after cardiac death, and split liver) may have traded wait-list for post-transplant morbidity and mortality. This article delineates the nature and severity of risk associated with specific deceased donor liver characteristics and recommends strategies to maximally mitigate these risks. PMID:25017080

  5. Quartic Rotation Criteria and Algorithms.

    ERIC Educational Resources Information Center

    Clarkson, Douglas B.; Jennrich, Robert I.

    1988-01-01

    Most of the current analytic rotation criteria for simple structure in factor analysis are summarized and identified as members of a general symmetric family of quartic criteria. A unified development of algorithms for orthogonal and direct oblique rotation using arbitrary criteria from this family is presented. (Author/TJH)

  6. Criteria for Restructuring Postsecondary Education.

    ERIC Educational Resources Information Center

    Slaughter, Sheila

    1995-01-01

    Criteria most often used by higher education administrators in restructuring higher education in the 1980s and 1990s are outlined. A distinction is made between retrenchment and restructuring. Criteria recommended in the literature are compared with criteria actually used, and the results. Some alternatives are suggested. (MSE)

  7. Is DSM widely accepted by Japanese clinicians?

    PubMed

    Someya, T; Takahashi, M; Takahashi, M

    2001-10-01

    The Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III), a new standardized diagnostic system with multiaxial diagnosis, operational criteria and renewed definitions of mental disorders, was introduced in 1980 and prompted movements to reform conventions in Japanese psychiatry. This review overviews the initial response of Japanese clinicians to accept DSM-III, and its effects on the development of systematic research of psychiatric diagnosis. These new research activities include those on reliability of psychiatric diagnosis, application of various evaluation tools, discussion on the concept of mental disorders, relation of personality disorders with depressive disorders, and Taijin-kyofusho, or culturally distinctive phobia in Japan. A reference database search to survey the latest trend on psychiatric research indicated that the number of papers published by Japanese workers increased sharply after 1987, and DSM apparently greatly influenced their internationalization. Twenty years after the publication of DSM-III, a questionnaire on the use of DSM-IV was set out in 2000 to survey how widely DSM is utilized in clinical practice in Japan. Two hundred and twelve psychiatrists answered the questionnaire, and the results show that DSM has been accepted positively by the younger generation, while the older generation (over 40s) has still less interest in DSM, and DSM is used mainly for research purposes rather than in daily practice.

  8. Extending the Technology Acceptance Model: Policy Acceptance Model (PAM)

    NASA Astrophysics Data System (ADS)

    Pierce, Tamra

    There has been extensive research on how new ideas and technologies are accepted in society. This has resulted in the creation of many models that are used to discover and assess the contributing factors. The Technology Acceptance Model (TAM) is one that is a widely accepted model. This model examines people's acceptance of new technologies based on variables that directly correlate to how the end user views the product. This paper introduces the Policy Acceptance Model (PAM), an expansion of TAM, which is designed for the analysis and evaluation of acceptance of new policy implementation. PAM includes the traditional constructs of TAM and adds the variables of age, ethnicity, and family. The model is demonstrated using a survey of people's attitude toward the upcoming healthcare reform in the United States (US) from 72 survey respondents. The aim is that the theory behind this model can be used as a framework that will be applicable to studies looking at the introduction of any new or modified policies.

  9. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.

    PubMed

    Dubois, Bruno; Feldman, Howard H; Jacova, Claudia; Hampel, Harald; Molinuevo, José Luis; Blennow, Kaj; DeKosky, Steven T; Gauthier, Serge; Selkoe, Dennis; Bateman, Randall; Cappa, Stefano; Crutch, Sebastian; Engelborghs, Sebastiaan; Frisoni, Giovanni B; Fox, Nick C; Galasko, Douglas; Habert, Marie-Odile; Jicha, Gregory A; Nordberg, Agneta; Pasquier, Florence; Rabinovici, Gil; Robert, Philippe; Rowe, Christopher; Salloway, Stephen; Sarazin, Marie; Epelbaum, Stéphane; de Souza, Leonardo C; Vellas, Bruno; Visser, Pieter J; Schneider, Lon; Stern, Yaakov; Scheltens, Philip; Cummings, Jeffrey L

    2014-06-01

    In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD. PMID:24849862

  10. What is meant by the term acceptance of technology and locating the acceptance of the CCS Technology?

    NASA Astrophysics Data System (ADS)

    Harz, Mario; Vesper, Anton

    2013-04-01

    abstract: The formal language of logic expresses concepts and statements exactly. The logic of relations can serve as an important ressource for the philosophical analysis of technology and the construction of philosophical propositions about acceptance of technology. The theory of logical relations is used to investigate the theoretical structure of how acceptance of technologies can be revealed. The term "ordered tuple" helps to define the basis of the concept of logical relations. The term "acceptance of technology" refers to neither a thing nor a property; but to a complex relationship. The research refers to the study of the properties of this complex relationship. It examines the properties of reflexivity, total reflexivity, symmetry, transitivity, irreflexivity and asymmetry. Using these properties and the rules for forming converses-relations and partial-relations the question is analyzed: What, in general, is meant by the term "acceptance of technology?" These properties have been observed empirically at a discussion forum for the key players in the Brandenburg discourse on the acceptance of CCS technology. The meeting was held on the 8th of May 2012 in St. Nicholas Church, Cottbus (GER). The pragma-dialectical theory of argumentation is used to locate the acceptance of the CCS technology. With the ideal model of critical discussion as the methodological starting point the term "acceptance" can be defined in terms of the four meta-theoretical principles of the theory. That boils down to the findings that acceptance is the externalization of a positive commitment towards a proposition, acceptance is expressed by the speech act "to accept" and acceptance occurs in the dialogical, interactional setting of a critical discussion with the aim of resolving a difference of opinion. In the study differences of opinion about (descriptive, normative, evaluative) standpoints about the CCS technology from everyday problem-solving discussions are investigated. The

  11. Preliminary criteria for the fracture control of space shuttle structures

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The complex and multidisciplinary factors are presented which relate to the prevention of structural failure due to the initiation or propagation of cracks or crack-like defects. The fracture control criteria are applicable to space shuttle components which are: (1) susceptible to cracking or fracture on the basis of anticipated loads and environment, and (2) critical to either crew safety or system performance. The criteria define the design, fabrication, environmental control, inspection, maintenance, repair, and verification procedures required for adequate fracture control.

  12. The Use and Abuse of Diagnostic/Classification Criteria

    PubMed Central

    June, Rayford R.; Aggarwal, Rohit

    2015-01-01

    In rheumatic diseases, classification criteria have been developed to identify well-defined homogenous cohorts for clinical research. Although, they are commonly used in clinical practice, their use may not be appropriate for routine diagnostic clinical care. Classification criteria are being revised with improved methodology and further understanding of disease pathophysiology, but still may not encompass all unique clinical situations to be applied for diagnosis of heterogeneous, rare, evolving rheumatic diseases. Diagnostic criteria development is challenging primarily due to difficulty for universal application given significant differences in prevalence of rheumatic diseases based on geographical area and clinic settings. Despite these shortcomings, the clinician can still use classification criteria for understanding the disease as well as a guide for diagnosis with a few caveats. We present the limits of current classification criteria, describe their use and abuse in clinical practice, and how they should be used with caution when applied in clinics. PMID:26096094

  13. L-286 Acceptance Test Record

    SciTech Connect

    HARMON, B.C.

    2000-01-14

    This document provides a detailed account of how the acceptance testing was conducted for Project L-286, ''200E Area Sanitary Water Plant Effluent Stream Reduction''. The testing of the L-286 instrumentation system was conducted under the direct supervision

  14. Accepted scientific research works (abstracts).

    PubMed

    2014-01-01

    These are the 39 accepted abstracts for IAYT's Symposium on Yoga Research (SYR) September 24-24, 2014 at the Kripalu Center for Yoga & Health and published in the Final Program Guide and Abstracts. PMID:25645134

  15. User-Defined Material Model for Progressive Failure Analysis

    NASA Technical Reports Server (NTRS)

    Knight, Norman F. Jr.; Reeder, James R. (Technical Monitor)

    2006-01-01

    An overview of different types of composite material system architectures and a brief review of progressive failure material modeling methods used for structural analysis including failure initiation and material degradation are presented. Different failure initiation criteria and material degradation models are described that define progressive failure formulations. These progressive failure formulations are implemented in a user-defined material model (or UMAT) for use with the ABAQUS/Standard1 nonlinear finite element analysis tool. The failure initiation criteria include the maximum stress criteria, maximum strain criteria, the Tsai-Wu failure polynomial, and the Hashin criteria. The material degradation model is based on the ply-discounting approach where the local material constitutive coefficients are degraded. Applications and extensions of the progressive failure analysis material model address two-dimensional plate and shell finite elements and three-dimensional solid finite elements. Implementation details and use of the UMAT subroutine are described in the present paper. Parametric studies for composite structures are discussed to illustrate the features of the progressive failure modeling methods that have been implemented.

  16. Criteria of quality and methods of measurement in multichannel biotelemetry.

    PubMed

    Kaltschmidt, H

    1975-01-01

    In contrast with one-channel biotelemetry, multichannel biotelemetry systems permit the analysis of biological systems by means of cybernetics. Some simple examples are given. The basic concept of a multichannel system is described. The criteria of quality of which the nonevident ones are defined by detailing the test circuits are the following (input criteria): number of channels, bandwidth, voltage range, impedance, maximum voltage outside the signal band, stability of the power supply for transducers, factor of safety against multipath propagation, distance between transmitter and receiver, shock, vibration and temperature range, weight, volume and operating time. Output criteria: signal-to-noise ratio, linearity, crosstalk transfer function, different time lags.

  17. Defined Syllabuses in Modern Languages

    ERIC Educational Resources Information Center

    Harding, Ann; Honnor, Sylvia

    1974-01-01

    The advantages of a defined syllabus in second language teaching, especially in relation to public examinations, are discussed. The origin and development of the York defined syllabuses are described, and extracts are given from the introductory document and the French and Russian syllabuses. (RM)

  18. Clarifying and Defining Library Services.

    ERIC Educational Resources Information Center

    Shubert, Joseph F., Ed.; Josey, E. J., Ed.

    1991-01-01

    This issue presents articles which, in some way, help to clarify and define library services. It is hoped that this clarification in library service will serve to secure the resources libraries need to serve the people of New York. The following articles are presented: (1) Introduction: "Clarifying and Defining Library Services" (Joseph F.…

  19. Acceptance test report for the Westinghouse 100 ton hydraulic trailer

    SciTech Connect

    Barrett, R.A.

    1995-03-06

    The SY-101 Equipment Removal System 100 Ton Hydraulic Trailer was designed and built by KAMP Systems, Inc. Performance of the Acceptance Test Procedure at KAMP`s facility in Ontario, California (termed Phase 1 in this report) was interrupted by discrepancies noted with the main hydraulic cylinder. The main cylinder was removed and sent to REMCO for repair while the trailer was sent to Lampson`s facility in Pasco, Washington. The Acceptance Test Procedure was modified and performance resumed at Lampson (termed Phase 2 in this report) after receipt of the repaired cylinder. At the successful conclusion of Phase 2 testing the trailer was accepted as meeting all the performance criteria specified.

  20. Correlation-tensor criteria for genuine multiqubit entanglement

    SciTech Connect

    Laskowski, Wieslaw; Markiewicz, Marcin; Zukowski, Marek; Paterek, Tomasz

    2011-12-15

    We present a development of a geometric approach to entanglement indicators. The method is applied to detect genuine multiqubit entanglement. The criteria are given in the form of nonlinear conditions imposed on correlation tensors. Thus they involve directly observable quantities, and in some cases require only few specific measurements to find multiqubit entanglement. The nonlinearity of each of the criteria allows detection of entanglement in wide classes of states. In contrast to entanglement witnesses, which in the space of Hermitian operators define a hyperplane, these conditions define a geometric figure encapsulating the nonfully entangled states within it.

  1. Proliferation resistance criteria for fissile material disposition issues

    SciTech Connect

    Rutherford, D.A.; Fearey, B.L.; Markin, J.T.; Close, D.A.; Tolk, K.M.; Mangan, D.L.; Moore, L.

    1995-09-01

    The 1994 National Acdaemy of Sciences study ``Management and Disposition of Excess Weapons Plutonium`` defined options for reducing the national and international proliferation risks of materials declared excess to the nuclear weapons program. This paper proposes criteria for assessing the proliferation resistance of these options as well defining the ``Standards`` from the report. The criteria are general, encompassing all stages of the disposition process from storage through intermediate processing to final disposition including the facilities, processing technologies and materials, the level of safeguards for these materials, and the national/subnational threat to the materials.

  2. FHR Generic Design Criteria

    SciTech Connect

    Flanagan, G.F.; Holcomb, D.E.; Cetiner, S.M.

    2012-06-15

    The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC)–based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

  3. FHR Generic Design Criteria

    SciTech Connect

    Flanagan, George F; Holcomb, David Eugene; Cetiner, Sacit M

    2012-06-01

    The purpose of this document is to provide an initial, focused reference to the safety characteristics of and a licensing approach for Fluoride-Salt-Cooled High-Temperature Reactors (FHRs). The document does not contain details of particular reactor designs nor does it attempt to identify or classify either design basis or beyond design basis accidents. Further, this document is an initial attempt by a small set of subject matter experts to document the safety and licensing characteristics of FHRs for a larger audience. The document is intended to help in setting the safety and licensing research, development, and demonstration path forward. Input from a wider audience, further technical developments, and additional study will be required to develop a consensus position on the safety and licensing characteristics of FHRs. This document begins with a brief overview of the attributes of FHRs and then a general description of their anticipated safety performance. Following this, an overview of the US nuclear power plant approval process is provided that includes both test and power reactors, as well as the role of safety standards in the approval process. The document next describes a General Design Criteria (GDC) - based approach to licensing an FHR and provides an initial draft set of FHR GDCs. The document concludes with a description of a path forward toward developing an FHR safety standard that can support both a test and power reactor licensing process.

  4. Response criteria for glioma.

    PubMed

    Sorensen, A Gregory; Batchelor, Tracy T; Wen, Patrick Y; Zhang, Wei-Ting; Jain, Rakesh K

    2008-11-01

    The current method for assessing the response to therapy of glial tumors was described by Macdonald et al. in 1990. Under this paradigm, response categorization is determined on the basis of changes in the cross-sectional area of a tumor on neuroimaging, coupled with clinical assessment of neurological status and corticosteroid utilization. These categories of response have certain limitations; for example, cross-sectional assessment is not as accurate as volumetric assessment, which is now feasible. Disentangling antitumor effects of therapies from their effects on blood-brain barrier permeability can be challenging. The use of insufficient response criteria might be overestimating the true benefits of drugs in early-stage studies, and, therefore, such therapies could mistakenly move forward into later phases, only to result in disappointment when overall survival is measured. We propose that studies report both radiographic and clinical response rates, use volumetric rather than cross-sectional area to measure lesion size, and incorporate findings from mechanistic imaging and blood biomarker studies more frequently, and also suggest that investigators recognize the limitations of imaging biomarkers as surrogate end points.

  5. Do You Have an Internet Acceptable Use Policy?

    ERIC Educational Resources Information Center

    Perks, Dennis J.; Gavitt, Donna R.; Olivo, John J.

    1997-01-01

    Developing an Internet acceptable use policy is the first step in bringing technological change to the classroom. This article defines educator's proactive responsibilities and provides a policy shell (privilege, "netiquette," security, vandalism, legal issues, warranties, and user agreements) to formulate individual school policies. Lists…

  6. Gout Classification Criteria: Update and Implications

    PubMed Central

    Vargas-Santos, Ana Beatriz; Taylor, William J.

    2016-01-01

    Gout is the most common inflammatory arthritis, with a rising prevalence and incidence worldwide. There has been a resurgence in gout research, fueled, in part, by a number of advances in pharmacologic therapy for gout. The conduct of clinical trials and other observational research in gout requires a standardized and validated means of assembling well-defined groups of patients with gout for such research purposes. Recently, an international collaborative effort that involved a data-driven process with state-of-the art methodology supported by the American College of Rheumatology and the European League Against Rheumatism led to publication of new gout classification criteria. PMID:27342957

  7. Gout Classification Criteria: Update and Implications.

    PubMed

    Vargas-Santos, Ana Beatriz; Taylor, William J; Neogi, Tuhina

    2016-07-01

    Gout is the most common inflammatory arthritis, with a rising prevalence and incidence worldwide. There has been a resurgence in gout research, fueled, in part, by a number of advances in pharmacologic therapy for gout. The conduct of clinical trials and other observational research in gout requires a standardized and validated means of assembling well-defined groups of patients with gout for such research purposes. Recently, an international collaborative effort that involved a data-driven process with state-of-the art methodology supported by the American College of Rheumatology and the European League Against Rheumatism led to publication of new gout classification criteria. PMID:27342957

  8. Toward optimizing patient-specific IMRT QA techniques in the accurate detection of dosimetrically acceptable and unacceptable patient plans

    SciTech Connect

    McKenzie, Elizabeth M.; Balter, Peter A.; Stingo, Francesco C.; Jones, Jimmy; Followill, David S.; Kry, Stephen F.

    2014-12-15

    Purpose: The authors investigated the performance of several patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA) dosimeters in terms of their ability to correctly identify dosimetrically acceptable and unacceptable IMRT patient plans, as determined by an in-house-designed multiple ion chamber phantom used as the gold standard. A further goal was to examine optimal threshold criteria that were consistent and based on the same criteria among the various dosimeters. Methods: The authors used receiver operating characteristic (ROC) curves to determine the sensitivity and specificity of (1) a 2D diode array undergoing anterior irradiation with field-by-field evaluation, (2) a 2D diode array undergoing anterior irradiation with composite evaluation, (3) a 2D diode array using planned irradiation angles with composite evaluation, (4) a helical diode array, (5) radiographic film, and (6) an ion chamber. This was done with a variety of evaluation criteria for a set of 15 dosimetrically unacceptable and 9 acceptable clinical IMRT patient plans, where acceptability was defined on the basis of multiple ion chamber measurements using independent ion chambers and a phantom. The area under the curve (AUC) on the ROC curves was used to compare dosimeter performance across all thresholds. Optimal threshold values were obtained from the ROC curves while incorporating considerations for cost and prevalence of unacceptable plans. Results: Using common clinical acceptance thresholds, most devices performed very poorly in terms of identifying unacceptable plans. Grouping the detector performance based on AUC showed two significantly different groups. The ion chamber, radiographic film, helical diode array, and anterior-delivered composite 2D diode array were in the better-performing group, whereas the anterior-delivered field-by-field and planned gantry angle delivery using the 2D diode array performed less well. Additionally, based on the AUCs, there

  9. Developing criteria for pediatric/adolescent bariatric surgery programs.

    PubMed

    Michalsky, Marc; Kramer, Robert E; Fullmer, Michelle A; Polfuss, Michele; Porter, Renee; Ward-Begnoche, Wendy; Getzoff, Elizabeth A; Dreyer, Meredith; Stolzman, Stacy; Reichard, Kirk W

    2011-09-01

    The prevalence of morbid obesity in adolescents is rising at an alarming rate. Comorbidities known to predispose to cardiovascular disease are increasingly being diagnosed in these children. Bariatric surgery has become an acceptable treatment alternative for morbidly obese adults, and criteria have been developed to establish center-of-excellence designation for adult bariatric surgery programs. Evidence suggests that bariatric surgical procedures are being performed with increasing numbers in adolescents. We have examined and compiled the current expert recommendations for guidelines and criteria that are needed to deliver safe and effective bariatric surgical care to adolescents.

  10. Beware of Publicity! Perceived Distress of Negative Cyber Incidents and Implications for Defining Cyberbullying

    ERIC Educational Resources Information Center

    Pieschl, Stephanie; Kuhlmann, Christina; Porsch, Torsten

    2015-01-01

    Cyberbullying is usually defined by utilizing offline criteria for bullying ("repetition," "power imbalance," "intent to harm"). However, this ignores the potential relevance of cyber-specific factors ("publicity," "medium," "type" [i.e., denigration]). We compared six factors, each with…

  11. Defining dysplasia in Barrett esophagus.

    PubMed

    Robert, Marie E

    2003-01-01

    Histologic grading of esophageal biopsies remains the cornerstone of management in patients with Barrett esophagus. This remains true despite ongoing research into the genetic abnormalities that occur in the setting of intestinal metaplasia, dysplasia, and adenocarcinoma of the esophagus. As of this writing, there are no objective tests that can replace the pathologist's eyes in predicting prognosis in this setting. However, pathologists and clinicians are well aware that the histologic interpretation of biopsies is an inherently subjective practice. The validity of this exercise depends entirely on the experience of the pathologist. Having said that, two interobserver studies on the grading of dysplasia in Barrett esophagus suggest that, if published criteria are adhered to, the histologic grading of dysplasia is a useful tool in patient management. In this review, the updated pathologic criteria for each category of dysplasia are presented, and the results of two large interobserver variability studies are reviewed.

  12. Acceptance of colonoscopy requires more than test tolerance

    PubMed Central

    Condon, Amanda; Graff, Lesley; Elliot, Lawrence; Ilnyckyj, Alexandra

    2008-01-01

    BACKGROUND: Colon cancer screening, including colonoscopy, lags behind other forms of cancer screening for participation rates. The intrinsic nature of the endoscopic procedure may be an important barrier that limits patients from finding this test acceptable and affects willingness to undergo screening. With colon cancer screening programs emerging in Canada, test characteristics and their impact on acceptance warrant consideration. OBJECTIVES: To measure the acceptability of colonoscopy and define factors that contribute to procedural acceptability, in relation to another invasive gastrointestinal scope procedure, gastroscopy. PATIENTS AND METHODS: Consecutive patients undergoing a colonoscopy (n=55) or a gastroscopy (n=33) were recruited. Their procedural experience was evaluated and compared pre-endoscopy, immediately before testing and postendoscopy. Questionnaires were used to capture multiple domains of the endoscopy experience and patient characteristics. RESULTS: Patient scope groups did not differ preprocedurally for general or procedure-specific anxiety. However, the colonoscopy group did anticipate more pain. Those who had a gastroscopy demonstrated higher preprocedural acceptance than those who had a colonoscopy. The colonoscopy group had a significant decrease in scope concerns and anxiety postprocedurally. As well, they reported less pain than they anticipated. Regardless, postprocedurally, the colonoscopy group’s acceptance did not increase significantly, whereas the gastroscopy group was almost unanimous in their test acceptance. The best predictor of pretest acceptability of colonoscopy was anticipated pain. CONCLUSIONS: The findings indicate that concerns that relate specifically to colonoscopy, including anticipated pain, influence acceptability of the procedure. However, the experience of a colonoscopy does not lead to improved test acceptance, despite decreases in procedural anxiety and pain. Patients’ preprocedural views of the test are

  13. ASAS classification criteria for axial spondyloarthritis: time to modify.

    PubMed

    Akkoc, Nurullah; Khan, Muhammad A

    2016-06-01

    The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being debated. The Food and Drug Agency (FDA) had criticized the ASAS criteria and the studies which used these criteria to enroll patients in a clinical trial of certolizumab and adalimumab for the treatment of non-radiographic axial spondyloarthritis. The primary aim of classification criteria is to create homogenous patient populations for basic and clinical research. But the multi-arm construct of the ASAS criteria is a potential source of heterogeneity reducing their utility. Criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances. We provide evidence to conclude that it is time to modify the ASAS Criteria for axSpA, and we propose some of the steps that can be taken to start moving forward in improving the validity of these criteria. PMID:27094940

  14. Evaluation Criteria for Solid Waste Processing Research and Technology Development

    NASA Technical Reports Server (NTRS)

    Levri, Julie A.; Hogan, J. A.; Alazraki, M. P.

    2001-01-01

    A preliminary list of criteria is proposed for evaluation of solid waste processing technologies for research and technology development (R&TD) in the Advanced Life Support (ALS) Program. Completion of the proposed list by current and prospective ALS technology developers, with regard to specific missions of interest, may enable identification of appropriate technologies (or lack thereof) and guide future development efforts for the ALS Program solid waste processing area. An attempt is made to include criteria that capture information about the technology of interest as well as its system-wide impacts. Some of the criteria in the list are mission-independent, while the majority are mission-specific. In order for technology developers to respond to mission-specific criteria, critical information must be available on the quantity, composition and state of the waste stream, the wast processing requirements, as well as top-level mission scenario information (e.g. safety, resource recovery, planetary protection issues, and ESM equivalencies). The technology readiness level (TRL) determines the degree to which a technology developer is able to accurately report on the list of criteria. Thus, a criteria-specific minimum TRL for mandatory reporting has been identified for each criterion in the list. Although this list has been developed to define criteria that are needed to direct funding of solid waste processing technologies, this list processes significant overlap in criteria required for technology selection for inclusion in specific tests or missions. Additionally, this approach to technology evaluation may be adapted to other ALS subsystems.

  15. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement

    PubMed Central

    Sachdev, Perminder; Kalaria, Raj; O’Brien, John; Skoog, Ingmar; Alladi, Suvarna; Black, Sandra E; Blacker, Deborah; Blazer, Dan; Chen, Christopher; Chui, Helena; Ganguli, Mary; Jellinger, Kurt; Jeste, Dilip V.; Pasquier, Florence; Paulsen, Jane; Prins, Niels; Rockwood, Kenneth; Roman, Gustavo; Scheltens, Philip

    2014-01-01

    Background Several sets of diagnostic criteria have been published for vascular dementia (VaD) since the 1960s. The continuing ambiguity in VaD definition warrants a critical re-examination. Methods Participants at a special symposium of the International Society for Vascular Behavioral and Cognitive Disorders (VASCOG) in 2009 critiqued the current criteria. They drafted a proposal for a new set of criteria, later reviewed through multiple drafts by the group, including additional experts and the members of the Neurocognitive Disorders Work Group of the DSM-5 Task Force. Results Cognitive disorders of vascular etiology are a heterogeneous group of disorders with diverse pathologies and clinical manifestations, discussed broadly under the rubric of vascular cognitive disorders (VCD). The continuum of vascular cognitive impairment is recognized by the categories of Mild Vascular Cognitive Disorder, and Vascular Dementia or Major Vascular Cognitive Disorder. Diagnostic thresholds are defined. Clinical and neuroimaging criteria are proposed for establishing vascular etiology. Subtypes of VCD are described, and the frequent co-occurrence of Alzheimer’s disease pathology emphasized. Conclusions The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathological validation studies. These criteria can be harmonized with the DSM-5 criteria such that an international consensus on the criteria for VCD may be achieved. PMID:24632990

  16. Animal innovation defined and operationalized.

    PubMed

    Ramsey, Grant; Bastian, Meredith L; van Schaik, Carel

    2007-08-01

    Innovation is a key component of most definitions of culture and intelligence. Additionally, innovations may affect a species' ecology and evolution. Nonetheless, conceptual and empirical work on innovation has only recently begun. In particular, largely because the existing operational definition (first occurrence in a population) requires long-term studies of populations, there has been no systematic study of innovation in wild animals. To facilitate such study, we have produced a new definition of innovation: Innovation is the process that generates in an individual a novel learned behavior that is not simply a consequence of social learning or environmental induction. Using this definition, we propose a new operational approach for distinguishing innovations in the field. The operational criteria employ information from the following sources: (1) the behavior's geographic and local prevalence and individual frequency; (2) properties of the behavior, such as the social role of the behavior, the context in which the behavior is exhibited, and its similarity to other behaviors; (3) changes in the occurrence of the behavior over time; and (4) knowledge of spontaneous or experimentally induced behavior in captivity. These criteria do not require long-term studies at a single site, but information from multiple populations of a species will generally be needed. These criteria are systematized into a dichotomous key that can be used to assess whether a behavior observed in the field is likely to be an innovation.

  17. The Problem of Defining Intelligence.

    ERIC Educational Resources Information Center

    Lubar, David

    1981-01-01

    The major philosophical issues surrounding the concept of intelligence are reviewed with respect to the problems surrounding the process of defining and developing artificial intelligence (AI) in computers. Various current definitions and problems with these definitions are presented. (MP)

  18. Acceptance of nicotine dependence treatment among currently depressed smokers.

    PubMed

    Haug, Nancy A; Hall, Sharon M; Prochaska, Judith J; Rosen, Amy B; Tsoh, Janice Y; Humfleet, Gary; Delucchi, Kevin; Rossi, Joseph S; Redding, Colleen A; Eisendrath, Stuart

    2005-04-01

    This study reports on baseline characteristics associated with acceptance and refusal of available smoking treatment among currently depressed smokers in a psychiatric outpatient clinic who were enrolled in a larger clinical trial. The sample (N=154) was 68% female and 72% White, with a mean age of 41.4 years and average smoking rate of 17 cigarettes/day. All participants were assigned to a repeated contact experimental condition; received a stage-based expert system program to facilitate treatment acceptance; and were then offered smoking treatment, consisting of behavioral counseling, nicotine patch, and bupropion. Acceptors (n=53) were defined as those accepting behavioral counseling and pharmacological treatment at some point during the 18-month study, whereas refusers (n=101) received only the expert system. The number of days to treatment acceptance was significantly predicted by stage of change, with those in preparation entering treatment more quickly than contemplators or precontemplators. In a logistic regression, the variables most strongly associated with accepting treatment were current use of psychiatric medication and perceived success for quitting. Severity of depressive symptoms, duration of depression history, and history of recurrent depression were not related to treatment acceptance. Findings have implications for the psychiatric assessment and treatment of smokers in clinical settings. Psychiatric medication may play a significant role in smoking cessation treatment acceptance by currently depressed smokers. PMID:16036278

  19. From requirements to acceptance tests

    NASA Technical Reports Server (NTRS)

    Baize, Lionel; Pasquier, Helene

    1993-01-01

    From user requirements definition to accepted software system, the software project management wants to be sure that the system will meet the requirements. For the development of a telecommunication satellites Control Centre, C.N.E.S. has used new rules to make the use of tracing matrix easier. From Requirements to Acceptance Tests, each item of a document must have an identifier. A unique matrix traces the system and allows the tracking of the consequences of a change in the requirements. A tool has been developed, to import documents into a relational data base. Each record of the data base corresponds to an item of a document, the access key is the item identifier. Tracing matrix is also processed, providing automatically links between the different documents. It enables the reading on the same screen of traced items. For example one can read simultaneously the User Requirements items, the corresponding Software Requirements items and the Acceptance Tests.

  20. NASA Glenn Wind Tunnel Model Systems Criteria

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.; Roeder, James W.; Stark, David E.; Linne, Alan A.

    2004-01-01

    This report describes criteria for the design, analysis, quality assurance, and documentation of models that are to be tested in the wind tunnel facilities at the NASA Glenn Research Center. This report presents two methods for computing model allowable stresses on the basis of the yield stress or ultimate stress, and it defines project procedures to test models in the NASA Glenn aeropropulsion facilities. Both customer-furnished and in-house model systems are discussed. The functions of the facility personnel and customers are defined. The format for the pretest meetings, safety permit process, and model reviews are outlined. The format for the model systems report (a requirement for each model that is to be tested at NASA Glenn) is described, the engineers responsible for developing the model systems report are listed, and the timetable for its delivery to the project engineer is given.

  1. Consumer acceptance and carcass quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In commodity production systems, beef quality is designated based on the USDA grading criteria which take into account carcass marbling, maturity and yield. Producers are rewarded economically for beef quality grade (QG) of Choice versus Select although the price difference (spread) varies seasonal...

  2. Peer Assessment without Assessment Criteria

    ERIC Educational Resources Information Center

    Jones, Ian; Alcock, Lara

    2014-01-01

    Peer assessment typically requires students to judge peers' work against assessment criteria. We tested an alternative approach in which students judged pairs of scripts against one another in the absence of assessment criteria. First year mathematics undergraduates (N?=?194) sat a written test on conceptual understanding of multivariable…

  3. Criteria for Evaluating Advancement Programs.

    ERIC Educational Resources Information Center

    Heemann, Warren, Ed.

    Criteria for evaluating college and university advancement programs are presented, based on the efforts of professional area trustees and advisory committees of the Council for Advancement and Support of Education (CASE). The criteria can be useful in three ways: as the basis of internal audits of advancement programs or program components; as the…

  4. [Diagnostic criteria in acute neuromyelitis].

    PubMed

    Panea, Cristina; Petrescu, Simona; Monica, Pop; Voinea, Liliana; Dascălu, Ana-Maria; Nicolae, Miruna; Ungureanu, E; Panca, Aida; Grădinaru, Sânziana

    2007-01-01

    Neuromyelitis optica, also known as Devic disease, was identified in the 19th century, is one of the inflammatory idiopathic demyelinating diseases of the central nervous system, often mistaken for severe multiple sclerosis. In 1999 it had been proposed diagnostic criteria for neuromyelitis optica, but in 2006 these criteria were revised by Dean Wingerchuck. These criteria are 99% sensitive and 90% specific for differentiating neuromyelitis optica from multiple sclerosis that present with optic neuritis or a myelitis syndrome. In the following article we present clinical, spinal and cerebral MR imaging, serological and aspects of cerebrospinal fluid examination features of neuromyelitis optica and the revised criteria of neuromyelitis optica established in 2006. The recently identified serum antibody biomarker: neuromyelitis optica immunoglobulin G (NMO Ig G), which target aquaporin 4 water channel, distinguish neuromyelitis optica from multiple sclerosis, is one of the revised criteria of neuromyelitis optica. PMID:18543687

  5. Noise and vibration ride comfort criteria

    NASA Technical Reports Server (NTRS)

    Dempsey, T. K.; Leatherwood, J. D.; Clevenson, S. A.

    1976-01-01

    A program is underway at Langley Research Center to develop a comprehensive ride quality model based upon the various physical and psychological factors that most affect passenger ride comfort. Two of the most important factors, namely, vibration and noise were studied to (1) determine whether composite or separate noise and vibration criteria are needed for the prediction of ride quality, (2) determine a noise correction for the previously-defined vibration criteria of the ride quality model, (3) assess whether these noise corrections depend on the nature of the vibration stimuli, i.e., deterministic as opposed to random, and (4) specify noise-vibration criteria for this combined environment. The stimuli for the study consisted of octave bands of noise centered at 500 or 2000 Hz and vertical vibrations composed of either 5 Hz sinusoidal vibration or random vibrations centered at 5 Hz and with a 5 Hz bandwidth. The noise stimuli were presented at levels ranging from ambient to 95 dB(A) and the vibrations at levels ranging from 0.02 to 0.13 g-rms.

  6. Imaginary Companions and Peer Acceptance

    ERIC Educational Resources Information Center

    Gleason, Tracy R.

    2004-01-01

    Early research on imaginary companions suggests that children who create them do so to compensate for poor social relationships. Consequently, the peer acceptance of children with imaginary companions was compared to that of their peers. Sociometrics were conducted on 88 preschool-aged children; 11 had invisible companions, 16 had personified…

  7. Acceptance of Others (Number Form).

    ERIC Educational Resources Information Center

    Masters, James R.; Laverty, Grace E.

    As part of the instrumentation to assess the effectiveness of the Schools Without Failure (SWF) program in 10 elementary schools in the New Castle, Pa. School District, the Acceptance of Others (Number Form) was prepared to determine pupil's attitudes toward classmates. Given a list of all class members, pupils are asked to circle a number from 1…

  8. W-025, acceptance test report

    SciTech Connect

    Roscha, V.

    1994-10-04

    This acceptance test report (ATR) has been prepared to establish the results of the field testing conducted on W-025 to demonstrate that the electrical/instrumentation systems functioned as intended by design. This is part of the RMW Land Disposal Facility.

  9. Euthanasia Acceptance: An Attitudinal Inquiry.

    ERIC Educational Resources Information Center

    Klopfer, Fredrick J.; Price, William F.

    The study presented was conducted to examine potential relationships between attitudes regarding the dying process, including acceptance of euthanasia, and other attitudinal or demographic attributes. The data of the survey was comprised of responses given by 331 respondents to a door-to-door interview. Results are discussed in terms of preferred…

  10. Helping Our Children Accept Themselves.

    ERIC Educational Resources Information Center

    Gamble, Mae

    1984-01-01

    Parents of a child with muscular dystrophy recount their reactions to learning of the diagnosis, their gradual acceptance, and their son's resistance, which was gradually lessened when he was provided with more information and treated more normally as a member of the family. (CL)

  11. Acceptance and Commitment Therapy: Introduction

    ERIC Educational Resources Information Center

    Twohig, Michael P.

    2012-01-01

    This is the introductory article to a special series in Cognitive and Behavioral Practice on Acceptance and Commitment Therapy (ACT). Instead of each article herein reviewing the basics of ACT, this article contains that review. This article provides a description of where ACT fits within the larger category of cognitive behavior therapy (CBT):…

  12. Who accepts first aid training?

    PubMed

    Pearn, J; Dawson, B; Leditschke, F; Petrie, G; Nixon, J

    1980-09-01

    The percentage of individuals trained in first aid skills in the general community is inadequate. We report here a study to investigate factors which influence motivation to accept voluntary training in first aid. A group of 700 randomly selected owners of inground swimming pools (a parental high-risk group) was offered a course of formal first aid instruction. Nine per cent attended the offered training course. The time commitment involved in traditional courses (eight training nights spread over four weeks) is not a deterrent, the same percentage accepting such courses as that who accept a course of one night's instruction. Cost is an important deterrent factor, consumer resistance rising over 15 cost units (one cost unit = the price of a loaf of bread). The level of competent first aid training within the community can be raised by (a) keeping to traditional course content, but (b) by ensuring a higher acceptance rate of first aid courses by a new approach to publicity campaigns, to convince prospective students of the real worth of first aid training. Questions concerning who should be taught first aid, and factors influencing motivation, are discussed.

  13. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds.

    PubMed

    Astronomo, Rena D; Kaltgrad, Eiton; Udit, Andrew K; Wang, Sheng-Kai; Doores, Katie J; Huang, Cheng-Yuan; Pantophlet, Ralph; Paulson, James C; Wong, Chi-Huey; Finn, M G; Burton, Dennis R

    2010-04-23

    The broadly neutralizing antibody 2G12 recognizes a conserved cluster of high-mannose glycans on the surface envelope spike of HIV, suggesting that the "glycan shield" defense of the virus can be breached and may, under the right circumstances, serve as a vaccine target. In an attempt to recreate features of the glycan shield semisynthetically, oligomannosides were coupled to surface lysines on the icosahedral capsids of bacteriophage Q beta and cowpea mosaic virus (CPMV). The Q beta glycoconjugates, but not CPMV, presented oligomannose clusters that bind the antibody 2G12 with high affinity. However, antibodies against these 2G12 epitopes were not detected in immunized rabbits. Rather, alternative oligomannose epitopes on the conjugates were immunodominant and elicited high titers of anti-mannose antibodies that do not crossreact with the HIV envelope. The results presented reveal important design considerations for a carbohydrate-based vaccine component for HIV. PMID:20416507

  14. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds.

    PubMed

    Astronomo, Rena D; Kaltgrad, Eiton; Udit, Andrew K; Wang, Sheng-Kai; Doores, Katie J; Huang, Cheng-Yuan; Pantophlet, Ralph; Paulson, James C; Wong, Chi-Huey; Finn, M G; Burton, Dennis R

    2010-04-23

    The broadly neutralizing antibody 2G12 recognizes a conserved cluster of high-mannose glycans on the surface envelope spike of HIV, suggesting that the "glycan shield" defense of the virus can be breached and may, under the right circumstances, serve as a vaccine target. In an attempt to recreate features of the glycan shield semisynthetically, oligomannosides were coupled to surface lysines on the icosahedral capsids of bacteriophage Q beta and cowpea mosaic virus (CPMV). The Q beta glycoconjugates, but not CPMV, presented oligomannose clusters that bind the antibody 2G12 with high affinity. However, antibodies against these 2G12 epitopes were not detected in immunized rabbits. Rather, alternative oligomannose epitopes on the conjugates were immunodominant and elicited high titers of anti-mannose antibodies that do not crossreact with the HIV envelope. The results presented reveal important design considerations for a carbohydrate-based vaccine component for HIV.

  15. Defining Eligibility Criteria for Preventive Early Intervention in an NICU Population.

    ERIC Educational Resources Information Center

    O'Brien, Marion; Rice, Mabel; Roy, Carolyn

    1996-01-01

    This study evaluated the usefulness of perinatal medical status, environmental risk, and infant developmental status as predictors of low IQ at age 4 among 70 4-year-olds who had been in a neonatal intensive care unit at birth. It found family environment the most predictive, 18-month developmental assessments somewhat useful, and perinatal health…

  16. Defining criteria for anti-mannan antibodies to protect against candidiasis.

    PubMed

    Cutler, J E

    2005-06-01

    Prevention of hematogenously disseminated candidiasis and mucocutaneous disease, including Candida vaginitis, through immunological approaches is appealing for the following reason. A long-acting and safe vaccine that protects against both serotypes of Candida albicans and other important species, such as C. tropicalis and C. glabrata, should significantly reduce the incidence of various forms of candidiasis by these etiologic agents. Through extensive experimentation on protective responses in experimental animals against Candida mannan components, others and we have evidence that antibodies specific for short-chain beta-linked oligomannosides are protective against candidiasis. Although the mechanism of protection against vaginal infection requires further investigation, experimentally the ability of antibody to rapidly deposit high amounts of complement factor C3 onto the yeast cell wall is requisite for enhancing resistance against disseminated candidiasis.

  17. Preliminary vibration, acoustic, and shock design and test criteria for components on the SRB, ET, and SSME

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Specifications for vibration, acoustic and shock design for components and subassemblies on the External Tank (ET), Solid Rocket Booster (SRB), and Space Shuttle Main Engine (SSME). Included are vibration, acoustic, shock, transportation, handling, and acceptance test requirements and procedures. The space shuttle ET, SRB, and SSME have been divided into zones and subzones. Zones are designated primarily to assist in determining the applicable specifications. A subzone (General Specification) is available for use when the location of the component is known but component design and weight are not well defined. When the location, weight, and mounting configuration of the component are known, specifications for appropriate subzone weight ranges are available. Criteria for some specific components are also presented.

  18. A multi-criteria approach for assessing options to remediate arsenic in drinking water.

    PubMed

    Ellis, Bryan; Garelick, Hemda

    2008-01-01

    The identification of best practice technologies to remediate arsenic-enriched drinking water involves the resolution of several technical, environmental, economic, and social factors. Multi-criteria analysis (MCA) provides a procedure to sort through diverse influencing factors as a means of facilitating the stakeholder decision-making process. The primary key MCA criteria used to define arsenic treatment options are expressed as source-exposure vector, health risk, cost, social acceptance, and technical competency. MCA not only can handle a complex mix of quantitative and qualitative information but also fosters means to resolve conflicting stakeholder opinion (or strategies). The MCA procedure involves construction of a performance matrix from utility scores for each key performance indicator (KPIs) that may influence outcomes. Data in the performance matrix are converted into numerical values through application of a specific utility scale scoring and weighting technique for each criterion. Inspection of the performance matrix scores facilitates decision making because they summarize arsenic treatment options numerically for all important criteria and KPIs. The weighting procedure enables stakeholder preferences (or strategies) to be incorporated into the selection process. Given the "fuzzy logic" nature of the KPI information, uncertainty may influence data outcome; this can be addressed by using an outranking procedure such as ELECTRE III or a simpler "swing" pairwise preference method. Sensitivity analysis can also be performed by reiterating the analysis using different utility scores and/or weights to assess influence on performance matrix outcomes. This approach enables the MCA methodology to be used as a negotiating tool in the decision-making process and allows areas of stakeholder agreement and disagreement to be highlighted.

  19. Stopping Criteria for Log-Domain Diffeomorphic Demons Registration: An Experimental Survey for Radiotherapy Application

    PubMed Central

    Peroni, M.; Golland, P.; Sharp, G. C.; Baroni, G.

    2016-01-01

    A crucial issue in deformable image registration is achieving a robust registration algorithm at a reasonable computational cost. Given the iterative nature of the optimization procedure an algorithm must automatically detect convergence, and stop the iterative process when most appropriate. This paper ranks the performances of three stopping criteria and six stopping value computation strategies for a Log-Domain Demons Deformable registration method simulating both a coarse and a fine registration. The analyzed stopping criteria are: (a) velocity field update magnitude, (b) mean squared error, and (c) harmonic energy. Each stopping condition is formulated so that the user defines a threshold ε, which quantifies the residual error that is acceptable for the particular problem and calculation strategy. In this work, we did not aim at assigning a value to ε, but to give insights in how to evaluate and to set the threshold on a given exit strategy in a very popular registration scheme. Experiments on phantom and patient data demonstrate that comparing the optimization metric minimum over the most recent three iterations with the minimum over the fourth to sixth most recent iterations can be an appropriate algorithm stopping strategy. The harmonic energy was found to provide best trade-off between robustness and speed of convergence for the analyzed registration method at coarse registration, but was outperformed by mean squared error when all the original pixel information is used. This suggests the need of developing mathematically sound new convergence criteria in which both image and vector field information could be used to detect the actual convergence, which could be especially useful when considering multi-resolution registrations. Further work should be also dedicated to study same strategies performances in other deformable registration methods and body districts. PMID:24000996

  20. Stopping Criteria for Log-Domain Diffeomorphic Demons Registration: An Experimental Survey for Radiotherapy Application.

    PubMed

    Peroni, M; Golland, P; Sharp, G C; Baroni, G

    2016-02-01

    A crucial issue in deformable image registration is achieving a robust registration algorithm at a reasonable computational cost. Given the iterative nature of the optimization procedure an algorithm must automatically detect convergence, and stop the iterative process when most appropriate. This paper ranks the performances of three stopping criteria and six stopping value computation strategies for a Log-Domain Demons Deformable registration method simulating both a coarse and a fine registration. The analyzed stopping criteria are: (a) velocity field update magnitude, (b) mean squared error, and (c) harmonic energy. Each stoping condition is formulated so that the user defines a threshold ∊, which quantifies the residual error that is acceptable for the particular problem and calculation strategy. In this work, we did not aim at assigning a value to e, but to give insights in how to evaluate and to set the threshold on a given exit strategy in a very popular registration scheme. Experiments on phantom and patient data demonstrate that comparing the optimization metric minimum over the most recent three iterations with the minimum over the fourth to sixth most recent iterations can be an appropriate algorithm stopping strategy. The harmonic energy was found to provide best trade-off between robustness and speed of convergence for the analyzed registration method at coarse registration, but was outperformed by mean squared error when all the original pixel information is used. This suggests the need of developing mathematically sound new convergence criteria in which both image and vector field information could be used to detect the actual convergence, which could be especially useful when considering multi-resolution registrations. Further work should be also dedicated to study same strategies performances in other deformable registration methods and body districts. PMID:24000996

  1. Defining the states of consciousness.

    PubMed

    Tassi, P; Muzet, A

    2001-03-01

    Consciousness remains an elusive concept due to the difficulty to define what has been regarded for many years as a subjective experience, therefore irrelevant for scientific study. Recent development in this field of research has allowed to provide some new insight to a possible way to define consciousness. Going through the extensive literature in this domain, several perspectives are proposed to define this concept. (1) Consciousness and Attention may not reflect the same process. (2) Consciousness during wake and sleep may not involve the same mechanisms. (3) Besides physiological states of consciousness, human beings can experience modified states of consciousness either by self-training (transcendental meditation, hypnosis, etc.) or by drug intake (hallucinogens, anaesthetics, etc.). Altogether, we address the question of a more precise terminology, given the theoretical weight words can convey. To this respect, we propose different definitions for concepts like consciousness, vigilance, arousal and alertness as candidates to separate functional entities.

  2. Public Acceptance of Nuclear Energy in Mexico

    SciTech Connect

    Ramirez-Sanchez, Jose R.; Alonso, Gustavo; Palacios, H. Javier

    2006-07-01

    energy. Also we can say that in Mexico there are few nuclear information centers one is located at Laguna Verde power plant, and there is other one at Instituto Nacional de Investigaciones Nucleares (ININ). So if we want to improve public acceptance in Mexico we should design a well defined strategy to communicate nuclear issues to the public. This strategy should point out many aspects of nuclear power as discussed before. In addition, recent economic studies performed at ININ, indicate that, nuclear energy is currently is price competitive with other sources based on fossil fuels. This facts are currently under discussion with government entities, and now acceptance of government entities is increasing. Even there was a public announce of Mexican government in the sense that Mexico is considering the nuclear option as a part of its energy strategy for the near future. (authors)

  3. Update on diagnosis of acute rheumatic fever: 2015 Jones criteria

    PubMed Central

    Eroğlu, Ayşe Güler

    2016-01-01

    In the final Jones criteria, different diagnostic criteria were established for the diagnosis of acute rheumatic fever for low risk and moderate-high risk populations. Turkey was found to be compatible with moderate-high risk populations as a result of regional screenings performed in terms of acute rheumatic fever and rheumatic heart disease. The changes in the diagnostic criteria for low-risk populations include subclinical carditis found on echocardiogram as a major criterion in addition to carditis found clinically and a body temperature of 38.5°C and above as a minor criterion. In moderate-high risk populations including Turkey, subclinical carditis found on echocardiogram in addition to clinical carditis is used as a major criterion as a new amendment. In addition, aseptic monoarthritis and polyarthralgia are used as major criteria in addition to migratory arthritis and monoarhtralgia is used as a minor criterion among joint findings. However, differentiation of subclinical carditis from physiological valve regurgitation found in healthy individuals and exclusion of other diseases involving joints when aseptic monoarthritis and polyarthralgia are used as major criteria are very important. In addition, a body temperature of 38°C and above and an erythrocyte sedimentation rate of 30 mm/h and above have been accepted as minor criteria. The diagnostic criteria for the first attack have not been changed; three minor findings have been accepted in presence of previous sterptococcal infection in addition to the old cirteria for recurrent attacks. In the final Jones criteria, it has been recommended that patients who do not fully meet the diagnostic criteria of acute rheumatic fever should be treated as acute rheumatic fever if another diagnosis is not considered and should be followed up with benzathine penicilin prophylaxis for 12 months. It has been decided that these patients be evaluated 12 months later and a decision for continuation or discontinuation of

  4. 42 CFR 483.130 - PASARR determination criteria.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... this section, by category that take into account that certain diagnoses, levels of severity of illness... acute physical illness which— (i) Required hospitalization; and (ii) Does not meet all the criteria for....106(b)(2). (2) Terminal illness, as defined for hospice purposes in § 418.3 of this chapter;...

  5. 42 CFR 483.130 - PASARR determination criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... this section, by category that take into account that certain diagnoses, levels of severity of illness... illness which— (i) Required hospitalization; and (ii) Does not meet all the criteria for an exempt...) Terminal illness, as defined for hospice purposes in § 418.3 of this chapter; (3) Severe physical...

  6. 42 CFR 483.130 - PASARR determination criteria.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... this section, by category that take into account that certain diagnoses, levels of severity of illness... illness which— (i) Required hospitalization; and (ii) Does not meet all the criteria for an exempt...) Terminal illness, as defined for hospice purposes in § 418.3 of this chapter; (3) Severe physical...

  7. 42 CFR 483.130 - PASARR determination criteria.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... this section, by category that take into account that certain diagnoses, levels of severity of illness... acute physical illness which— (i) Required hospitalization; and (ii) Does not meet all the criteria for....106(b)(2). (2) Terminal illness, as defined for hospice purposes in § 418.3 of this chapter;...

  8. 42 CFR 483.130 - PASARR determination criteria.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... this section, by category that take into account that certain diagnoses, levels of severity of illness... acute physical illness which— (i) Required hospitalization; and (ii) Does not meet all the criteria for....106(b)(2). (2) Terminal illness, as defined for hospice purposes in § 418.3 of this chapter;...

  9. Designing and Teaching Courses To Satisfy Engineering Criteria 2000.

    ERIC Educational Resources Information Center

    Felder, Richard M.; Brent, Rebecca

    Since Engineering Criteria 2000 (EC 2000) was first introduced as the standard for American engineering education programs, most discussion in the literature has focused on how to assess Outcomes 3a-3k (specific outcomes or abilities engineering students must acquire as defined by the Accreditation Board of Engineering and Technology) and…

  10. 40 CFR Appendix C to Part 112 - Substantial Harm Criteria

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The... Pass, LA to Baton Rouge, LA; (7) Louisiana Offshore Oil Port (LOOP), LA; (8) Lake Charles, LA; (9... EPA Region. 1.1.3Inland Area means the area shoreward of the boundary lines defined in 46 CFR part...

  11. 40 CFR Appendix C to Part 112 - Substantial Harm Criteria

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The... Pass, LA to Baton Rouge, LA; (7) Louisiana Offshore Oil Port (LOOP), LA; (8) Lake Charles, LA; (9... EPA Region. 1.1.3Inland Area means the area shoreward of the boundary lines defined in 46 CFR part...

  12. 40 CFR Appendix C to Part 112 - Substantial Harm Criteria

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The... Pass, LA to Baton Rouge, LA; (7) Louisiana Offshore Oil Port (LOOP), LA; (8) Lake Charles, LA; (9... EPA Region. 1.1.3Inland Area means the area shoreward of the boundary lines defined in 46 CFR part...

  13. 40 CFR Appendix C to Part 112 - Substantial Harm Criteria

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The... Pass, LA to Baton Rouge, LA; (7) Louisiana Offshore Oil Port (LOOP), LA; (8) Lake Charles, LA; (9... EPA Region. 1.1.3Inland Area means the area shoreward of the boundary lines defined in 46 CFR part...

  14. 40 CFR Appendix C to Part 112 - Substantial Harm Criteria

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The... Pass, LA to Baton Rouge, LA; (7) Louisiana Offshore Oil Port (LOOP), LA; (8) Lake Charles, LA; (9... EPA Region. 1.1.3Inland Area means the area shoreward of the boundary lines defined in 46 CFR part...

  15. 9 CFR 439.10 - Criteria for obtaining accreditation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ACT ACCREDITATION OF NON-FEDERAL CHEMISTRY LABORATORIES § 439.10 Criteria for obtaining accreditation. (a) Analytical laboratories may be accredited for the analyses of food chemistry analytes, as defined... accreditation, the supervisor must also have one year's experience in food chemistry analysis, or...

  16. 9 CFR 439.10 - Criteria for obtaining accreditation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ACT ACCREDITATION OF NON-FEDERAL CHEMISTRY LABORATORIES § 439.10 Criteria for obtaining accreditation. (a) Analytical laboratories may be accredited for the analyses of food chemistry analytes, as defined... accreditation, the supervisor must also have one year's experience in food chemistry analysis, or...

  17. 9 CFR 439.10 - Criteria for obtaining accreditation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ACT ACCREDITATION OF NON-FEDERAL CHEMISTRY LABORATORIES § 439.10 Criteria for obtaining accreditation. (a) Analytical laboratories may be accredited for the analyses of food chemistry analytes, as defined... accreditation, the supervisor must also have one year's experience in food chemistry analysis, or...

  18. 5 CFR 551.205 - Executive exemption criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 551.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... criteria. (a) An executive employee is an employee whose primary duty is management (as defined in § 551... takes into consideration those organizations that use matrix management, i.e., a system of...

  19. 33 CFR 203.72 - Eligibility criteria and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Measures § 203.72 Eligibility criteria and procedures. (a) Threat of flooding. An imminent threat of unusual flooding must exist before Advance Measures projects can be approved. The threat may be... flooding from adverse or unusual conditions. The threat must be clearly defined to the extent that it...

  20. 33 CFR 203.72 - Eligibility criteria and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Measures § 203.72 Eligibility criteria and procedures. (a) Threat of flooding. An imminent threat of unusual flooding must exist before Advance Measures projects can be approved. The threat may be... flooding from adverse or unusual conditions. The threat must be clearly defined to the extent that it...

  1. 33 CFR 203.72 - Eligibility criteria and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Measures § 203.72 Eligibility criteria and procedures. (a) Threat of flooding. An imminent threat of unusual flooding must exist before Advance Measures projects can be approved. The threat may be... flooding from adverse or unusual conditions. The threat must be clearly defined to the extent that it...

  2. 9 CFR 439.10 - Criteria for obtaining accreditation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ACT ACCREDITATION OF NON-FEDERAL CHEMISTRY LABORATORIES § 439.10 Criteria for obtaining accreditation. (a) Analytical laboratories may be accredited for the analyses of food chemistry analytes, as defined... successfully satisfies the requirements presented below. For food chemistry accreditation, the...

  3. Manufacturing time operators: Covariance, selection criteria, and examples

    SciTech Connect

    Hegerfeldt, G. C.; Muga, J. G.; Munoz, J.

    2010-07-15

    We provide the most general forms of covariant and normalized time operators and their probability densities, with applications to quantum clocks, the time of arrival, and Lyapunov quantum operators. Examples are discussed of the profusion of possible operators and their physical meaning. Criteria to define unique, optimal operators for specific cases are given.

  4. Comparison of Accreditation Criteria: CBHDP, NLN, and COA Accreditation Criteria.

    ERIC Educational Resources Information Center

    Frels, Lois; Horton, Betty

    1991-01-01

    Presents a detailed comparison of similarities and differences in the accreditation criteria of two nursing accrediting agencies--the National League for Nursing and the Council on Accreditation--as they relate to nurse anesthesiology programs. (JOW)

  5. Increasing the Automation and Autonomy for Spacecraft Operations with Criteria Action Table

    NASA Technical Reports Server (NTRS)

    Li, Zhen-Ping; Savki, Cetin

    2005-01-01

    The Criteria Action Table (CAT) is an automation tool developed for monitoring real time system messages for specific events and processes in order to take user defined actions based on a set of user-defined rules. CAT was developed by Lockheed Martin Space Operations as a part of a larger NASA effort at the Goddard Space Flight Center (GSFC) to create a component-based, middleware-based, and standard-based general purpose ground system architecture referred as GMSEC - the GSFC Mission Services Evolution Center. CAT has been integrated into the upgraded ground systems for Tropical Rainfall Measuring Mission (TRMM) and Small Explorer (SMEX) satellites and it plays the central role in their automation effort to reduce the cost and increase the reliability for spacecraft operations. The GMSEC architecture provides a standard communication interface and protocol for components to publish/describe messages to an information bus. It also provides a standard message definition so components can send and receive messages to the bus interface rather than each other, thus reducing the component-to-component coupling, interface, protocols, and link (socket) management. With the GMSEC architecture, components can publish standard event messages to the bus for all nominal, significant, and surprising events in regard to satellite, celestial, ground system, or any other activity. In addition to sending standard event messages, each GMSEC compliant component is required to accept and process GMSEC directive request messages.

  6. Reproducibility of the World Health Organization 2008 criteria for myelodysplastic syndromes

    PubMed Central

    Senent, Leonor; Arenillas, Leonor; Luño, Elisa; Ruiz, Juan C.; Sanz, Guillermo; Florensa, Lourdes

    2013-01-01

    The reproducibility of the World Health Organization 2008 classification for myelodysplastic syndromes is uncertain and its assessment was the major aim of this study. The different peripheral blood and bone marrow variables required for an adequate morphological classification were blindly evaluated by four cytomorphologists in samples from 50 patients with myelodysplastic syndromes. The degree of agreement among observers was calculated using intraclass correlation coefficient and the generalized kappa statistic for multiple raters. The degree of agreement for the percentages of blasts in bone marrow and peripheral blood, ring sideroblasts in bone marrow, and erythroid, granulocytic and megakaryocytic dysplastic cells was strong (P<0.001 in all instances). After stratifying the percentages according to the categories required for the assignment of World Health Organization subtypes, the degree of agreement was not statistically significant for cases with 5-9% blasts in bone marrow (P=0.07), 0.1-1% blasts in peripheral blood (P=0.47), or percentage of erythroid dysplastic cells (P=0.49). Finally, the interobserver concordance for World Health Organization-defined subtypes showed a moderate overall agreement (P<0.001), the reproducibility being lower for cases with refractory anemia with excess of blasts type 1 (P=0.05) and refractory anemia with ring sideroblasts (P=0.09). In conclusion, the reproducibility of the World Health Organization 2008 classification for myelodysplastic syndromes is acceptable but the defining criteria for blast cells and features of erythroid dysplasia need to be refined. PMID:23065505

  7. Acceptable Knowledge Summary Report for Waste Stream: SR-T001-221F-HET/Drums

    SciTech Connect

    Lunsford, G.F.

    1999-06-14

    This report is fully responsive to the requirements of Section 4.0 Acceptable Knowledge from the WIPP Transuranic Waste Characterization Quality Assurance Plan, CAO-94-1010, and provides a sound, (and auditable) characterization that satisfies the WIPP criteria for Acceptable Knowledge.

  8. GNS-12 Packaging design criteria

    SciTech Connect

    Clements, E.P., Westinghouse Hanford

    1996-07-24

    The purpose of this Packaging Design Criteria (PDC) is to provide criteria for the Safety Analysis Report for Packaging (SARP)(Onsite). The SARP provides the evaluation to demonstrate that the onsite transportation safety criteria are met for the transport and storage of the 324 Building vitrified encapsulated material in the GNS-12 cask. In this application, the approved PDC provides a formal set of standards for the payload requirements, and guidance for the current cask transport configuration and a revised storage seal and primary lid modification design.

  9. Selection of donor and organ viability criteria: expanding donation criteria.

    PubMed

    Gutiérrez, E; Andrés, A

    2007-01-01

    Donation criteria have been becoming more flexible over the years. Currently, the only absolute exclusion criteria are human immunodeficiency virus infection (HIV), uncontrolled tumor disease and bacterial or viral infections. ClinicaL. conditions dictate organ viability criteria: biochemical, morphological and functional, that must be fulfilled by the donors and their organs in order to focus the decision on which donor organs can be used. These criteria attempt to assure that the transplanted organs function after the extraction, transformation, implantation and reperfusion process without transmitting any infectious or tumour disease. In recent years, the gross and microscopic appearance has become one of the fundamental criteria for selection of potentially viable organs. At present, there is no age limit for hepatic and renal donation; the principal contra-indication is chronic organ damage. The use of each organ must be decided individually after a profound analysis of all the viability criteria, weighing the advantages and disadvantages of the implant of a certain organ for the recipient. PMID:17702512

  10. Detection methods and performance criteria for genetically modified organisms.

    PubMed

    Bertheau, Yves; Diolez, Annick; Kobilinsky, André; Magin, Kimberly

    2002-01-01

    Detection methods for genetically modified organisms (GMOs) are necessary for many applications, from seed purity assessment to compliance of food labeling in several countries. Numerous analytical methods are currently used or under development to support these needs. The currently used methods are bioassays and protein- and DNA-based detection protocols. To avoid discrepancy of results between such largely different methods and, for instance, the potential resulting legal actions, compatibility of the methods is urgently needed. Performance criteria of methods allow evaluation against a common standard. The more-common performance criteria for detection methods are precision, accuracy, sensitivity, and specificity, which together specifically address other terms used to describe the performance of a method, such as applicability, selectivity, calibration, trueness, precision, recovery, operating range, limit of quantitation, limit of detection, and ruggedness. Performance criteria should provide objective tools to accept or reject specific methods, to validate them, to ensure compatibility between validated methods, and be used on a routine basis to reject data outside an acceptable range of variability. When selecting a method of detection, it is also important to consider its applicability, its field of applications, and its limitations, by including factors such as its ability to detect the target analyte in a given matrix, the duration of the analyses, its cost effectiveness, and the necessary sample sizes for testing. Thus, the current GMO detection methods should be evaluated against a common set of performance criteria.

  11. Defining "Folklore" in the Classroom.

    ERIC Educational Resources Information Center

    Falke, Anne

    Folklore, a body of traditional beliefs of a people conveyed orally or by means of custom, is very much alive, involves all people, and is not the study of popular culture. In studying folklore, the principal tasks of the folklorist have been defined as determining definition, classification, source (the folk), origin (who composed folklore),…

  12. Defining and Measuring Psychomotor Performance

    ERIC Educational Resources Information Center

    Autio, Ossi

    2007-01-01

    Psychomotor performance is fundamental to human existence. It is important in many real world activities and nowadays psychomotor tests are used in several fields of industry, army, and medical sciences in employee selection. This article tries to define psychomotor activity by introducing some psychomotor theories. Furthermore the…

  13. Risk-based versus deterministic explosives safety criteria

    SciTech Connect

    Wright, R.E.

    1996-12-01

    The Department of Defense Explosives Safety Board (DDESB) is actively considering ways to apply risk-based approaches in its decision- making processes. As such, an understanding of the impact of converting to risk-based criteria is required. The objectives of this project are to examine the benefits and drawbacks of risk-based criteria and to define the impact of converting from deterministic to risk-based criteria. Conclusions will be couched in terms that allow meaningful comparisons of deterministic and risk-based approaches. To this end, direct comparisons of the consequences and impacts of both deterministic and risk-based criteria at selected military installations are made. Deterministic criteria used in this report are those in DoD 6055.9-STD, `DoD Ammunition and Explosives Safety Standard.` Risk-based criteria selected for comparison are those used by the government of Switzerland, `Technical Requirements for the Storage of Ammunition (TLM 75).` The risk-based criteria used in Switzerland were selected because they have been successfully applied for over twenty-five years.

  14. Diagnostic criteria of autoimmune hepatitis.

    PubMed

    Liberal, Rodrigo; Grant, Charlotte R; Longhi, Maria Serena; Mieli-Vergani, Giorgina; Vergani, Diego

    2014-01-01

    Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disorder characterised by female preponderance, elevated transaminase and immunoglobulin G levels, seropositivity for autoantibodies and interface hepatitis. Presentation is highly variable, therefore AIH should be considered during the diagnostic workup of any increase in liver enzyme levels. A set of inclusion and exclusion criteria for the diagnosis of AIH have been established by the International Autoimmune Hepatitis Group (IAIHG). There are two main types of AIH: type 1, positive for anti-nuclear (ANA) and/or anti-smooth muscle antibodies (SMAs) and type 2, defined by the presence of anti-liver kidney microsomal antibody type 1 (LKM-1) and/or anti-liver cytosol type 1 (LC-1) autoantibodies. The central role of autoantibodies in the diagnosis of AIH has led the IAIHG to produce a consensus statement detailing appropriate and effective methods for their detection. Autoantibodies should be tested by indirect immunofluorescence at an initial dilution of 1/40 in adults and 1/10 in children on a freshly prepared rodent substrate that includes kidney, liver and stomach sections to allow for the simultaneous detection of all reactivities relevant to AIH. Anti-LKM-1 is often confused with anti-mitochondrial antibody (AMA) if rodent kidney is used as the sole immunofluorescence substrate. The identification of the molecular targets of anti-LKM-1 and AMA has led to the establishment of immuno-assays based on the use of the recombinant or purified autoantigens. Perinuclear anti-nuclear neutrophil antibody (p-ANNA) is an additional marker of AIH-1; anti soluble liver antigen (SLA) antibodies are specific for autoimmune liver disease, can be present in AIH-1 and AIH-2 and are associated with a more severe clinical course. Anti-SLA are detectable by ELISA or radio-immuno-assays, but not by immunofluorescence. AIH is exquisitely responsive to immunosuppressive treatment, which should be instituted promptly to

  15. Criteria for acceptable levels of the Shinkansen Super Express train noise and vibration in residential areas

    NASA Astrophysics Data System (ADS)

    Yamanaka, K.; Nakagawa, T.; Kobayashi, F.; Kanada, S.; Tanahashi, M.; Muramatsu, T.; Yamada, S.

    1982-10-01

    A survey of 1187 housewives living in 18 areas along the Shinkansen Super Express (bullet train) railway was conducted by means of a self-administered health questionnaire (modified Cornell Medical Index). In addition, geographically corresponding measurements of noise level and vibration intensity were taken. The relationship of noise and vibration to positive responses (health complaints) related to bodily symptoms, illness and emotional disturbances was analyzed. The factors which correlated with an increase in the average number of positive responses included noise, vibration, age and health status. Such factors as marital status, educational level, part time work, duration of inhabitancy and occupation of the head of the houshold correlated poorly with the number of positive responses. Unhealthy respondents compared to healthy respondents are more frequently affected by noise and vibration. The rate of positive responses in the visual, respiratory, cardiovascular, digestive and nervous systems, sleep disturbances and emotional disturbances increased accordingly as noise and vibration increased. Combined effects of noise and vibration stimuli on the total number of positive responses (an indicator of general health) were found. This study has produced results indicating that the maximum permissible noise level should not exceed 70 dB(A) in the residential areas along the Shinkansen railway.

  16. [Pandemic influenza vaccines. Concepts, European mock-up licenses, and acceptance criteria].

    PubMed

    Pfleiderer, M

    2010-12-01

    The concept of identifying appropriate scientific and regulatory principles to ensure rapid availability of pandemic influenza vaccines when needed were already developed starting in the year 2003. These principles allowed licensing of three so-called mock-up vaccines far ahead of any real presenting pandemic event. Those licenses (Marketing Authorizations) were immediately adapted to the novel H1N1 strain shortly after its identification in April 2009 ensuring that as early as September 2009 large parts of the German as well as of the EU population had access to licensed products which had undergone sufficient evaluation before first use in humans. In contrast, for pandemic vaccine concepts without a previously licensed mock-up version it generally took twice as much time to accumulate data supporting the granting of a Marketing Authorization. This article describes in detail the translation of concepts of producing, testing, and licensing of pandemic influenza vaccines into practice under real conditions. PMID:21161474

  17. 78 FR 65007 - Inspections, Tests, Analyses, and Acceptance Criteria; Vogtle Electric Generating Plant, Unit 3

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ...-available information related to this action by the following methods: Federal Rulemaking Web site: Go to..., select ``ADAMS Public Documents'' and then select ``Begin Web- based ADAMS Search.'' For problems with... updates to the status of this ITAAC will be reflected on the NRC's Web site at...

  18. 78 FR 38411 - Vogtle Electric Generating Plant, Unit 4; Inspections, Tests, Analyses, and Acceptance Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... of the following methods: Federal Rulemaking Web site: Go to http://www.regulations.gov and search... select ``Begin Web- based ADAMS Search.'' For problems with ADAMS, please contact the NRC's Public... will be reflected on the NRC's Web site at...

  19. 77 FR 51880 - Requirements for Maintenance of Inspections, Tests, Analyses, and Acceptance Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ...; Standard Design Certifications; and Combined Licenses for Nuclear Power Reactors'' on April 18, 1989 (54 FR... construction was complete. (See 54 FR 15372; April 18, 1989; at 15383 (second column)). On August 28, 2007 (72 FR 49352), the Commission revised 10 CFR part 52 to enhance the NRC's regulatory effectiveness...

  20. Acceptance criteria for welds in ASTM A106 grade B steel pipe and plate

    NASA Technical Reports Server (NTRS)

    Hudson, C. M.; Wright, D. B., Jr.; Leis, B. N.

    1986-01-01

    Based on the RECERT Program findings, NASA-Langley funded a fatigue study of code-unacceptable welds. Usage curves were developed which were based on the structural integrity of the welds. The details of this study are presented in NASA CR-178114. The information presented is a condensation and reinterpretation of the information in NASA CR-178114. This condensation and reinterpretation generated usage curves for welds having: (1) indications 0.20 -inch deep by 0.40-inch long, and (2) indications 0.195-inch deep by 8.4-inches long. These curves were developed using the procedures used in formulating the design curves in Section VIII, Division 2 of the American Society of Mechanical Engineers Boiler and Pressure Vessel Code.

  1. Improved Criteria for Acceptable Yield Point Elongation in Surface Critical Steels

    SciTech Connect

    Dr. David Matlock; Dr. John Speer

    2007-05-30

    Yield point elongation (YPE) is considered undesirable in surface critical applications where steel is formed since "strain lines" or Luders bands are created during forming. This project will examine in detail the formation of luders bands in industrially relevant strain states including the influence of substrate properties and coatings on Luders appearance. Mechanical testing and surface profilometry were the primary methods of investigation.

  2. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation.

    PubMed

    Lutton, Rebecca E M; Moore, Jessica; Larrañeta, Eneko; Ligett, Stephen; Woolfson, A David; Donnelly, Ryan F

    2015-08-01

    With interest in microneedles as a novel drug transdermal delivery system increasing rapidly since the late 1990s (Margetts and Sawyer Contin Educ Anaesthesia Crit Care Pain. 7(5):171-76, 2007), a diverse range of microneedle systems have been fabricated with varying designs and dimensions. However, there are still very few commercially available microneedle products. One major issue regarding microneedle manufacture on an industrial scale is the lack of specific quality standards for this novel dosage form in the context of Good Manufacturing Practice (GMP). A range of mechanical characterisation tests and microneedle insertion analysis techniques are used by researchers working on microneedle systems to assess the safety and performance profiles of their various designs. The lack of standardised tests and equipment used to demonstrate microneedle mechanical properties and insertion capability makes it difficult to directly compare the in use performance of candidate systems. This review highlights the mechanical tests and insertion analytical techniques used by various groups to characterise microneedles. This in turn exposes the urgent need for consistency across the range of microneedle systems in order to promote innovation and the successful commercialisation of microneedle products.

  3. Nutritional Criteria for Military Rations and Effects of Prolonged Feeding on Acceptability

    NASA Technical Reports Server (NTRS)

    Schnakenberg, D.

    1985-01-01

    Broad nutritional policies for operational rations are designed to insure that the nutritional content of the rations served will sustain combat effectiveness. Concern exists that these rations, although nutritionally complete, would become monotonous because of limited variety causing nutrient intake to decrease and body weight losses to occur with adverse effects on morale and combat effectiveness. Whenever possible, troops are now fed one or two hot meals per day containing fresh foods and a much greater variety of foods than are available in packaged rations. A laboratory test was conducted with student volunteers and the results are discussed.

  4. 46 CFR 164.019-7 - Non-standard components; acceptance criteria and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the applicable subpart of this part, and any other manufacturer's identifying data. No two components... showing details and dimensions of the mechanism. (7) A statement of dimensional and performance...

  5. 46 CFR 164.019-7 - Non-standard components; acceptance criteria and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the applicable subpart of this part, and any other manufacturer's identifying data. No two components... showing details and dimensions of the mechanism. (7) A statement of dimensional and performance...

  6. 46 CFR 164.019-7 - Non-standard components; acceptance criteria and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the applicable subpart of this part, and any other manufacturer's identifying data. No two components... showing details and dimensions of the mechanism. (7) A statement of dimensional and performance...

  7. 46 CFR 164.019-7 - Non-standard components; acceptance criteria and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the applicable subpart of this part, and any other manufacturer's identifying data. No two components... showing details and dimensions of the mechanism. (7) A statement of dimensional and performance...

  8. 46 CFR 164.019-7 - Non-standard components; acceptance criteria and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the applicable subpart of this part, and any other manufacturer's identifying data. No two components... showing details and dimensions of the mechanism. (7) A statement of dimensional and performance...

  9. Acceptance test procedure for the MO-293 (1722) 10-wide mobile office

    SciTech Connect

    Wallace, S.C.

    1994-12-28

    This Acceptance Test Procedure has been prepared to demonstrate that the Fire Protection System functions as required by project criteria. The test results will be issued as an acceptance test report after all the testing is complete. This facility is part of the Spent Nuclear Fuel Project. An appendix is provided as a checklist of activities to be performed by the fire alarm system installer to ensure proper installation and operation.

  10. Accepting the T3D

    SciTech Connect

    Rich, D.O.; Pope, S.C.; DeLapp, J.G.

    1994-10-01

    In April, a 128 PE Cray T3D was installed at Los Alamos National Laboratory`s Advanced Computing Laboratory as part of the DOE`s High-Performance Parallel Processor Program (H4P). In conjunction with CRI, the authors implemented a 30 day acceptance test. The test was constructed in part to help them understand the strengths and weaknesses of the T3D. In this paper, they briefly describe the H4P and its goals. They discuss the design and implementation of the T3D acceptance test and detail issues that arose during the test. They conclude with a set of system requirements that must be addressed as the T3D system evolves.

  11. Sweeteners: consumer acceptance in tea.

    PubMed

    Sprowl, D J; Ehrcke, L A

    1984-09-01

    Sucrose, fructose, aspartame, and saccharin were compared for consumer preference, aftertaste, and cost to determine acceptability of the sweeteners. A 23-member taste panel evaluated tea samples for preference and aftertaste. Mean retail cost of the sweeteners were calculated and adjusted to take sweetening power into consideration. Sucrose was the least expensive and most preferred sweetener. No significant difference in preference for fructose and aspartame was found, but both sweeteners were rated significantly lower than sucrose. Saccharin was the most disliked sweetener. Fructose was the most expensive sweetener and aspartame the next most expensive. Scores for aftertaste followed the same pattern as those for preference. Thus, a strong, unpleasant aftertaste seems to be associated with a dislike for a sweetener. From the results of this study, it seems that there is no completely acceptable low-calorie substitute for sucrose available to consumers.

  12. Application of the Supreme Court's Daubert criteria in radiation litigation.

    PubMed

    Merwin, S E; Moeller, D W; Kennedy, W E; Moeller, M P

    2001-12-01

    In 1993, the U.S. Supreme Court set forth the standard for determining the admissibility of expert scientific evidence in litigation. This standard is known as the Daubert criteria, named after the pertinent case, Daubert v. Merrell Dow Pharmaceuticals, Inc. The Daubert criteria require the courts to determine whether an expert's testimony reflects scientific knowledge, whether his/her findings are derived by the scientific method, and whether the work product is based on good science. The Daubert criteria are especially important in radiation litigation because issues involving radiation doses and effects are often complex and thus a jury will typically rely heavily on the analysis and opinions of experts. According to the Daubert criteria, scientific opinions must be based on a methodology that has a valid, testable hypothesis; has been subject to peer review; and is generally accepted in the scientific community. Additionally, the expert must be qualified to present opinions based on the methodology. Although the application of the Daubert criteria in radiation litigation is highly dependent on the specific court and judge presiding over the case, there have been recent high-profile cases in which application of the criteria has resulted in the dismissal of analysis and opinions offered by scientific experts. Reasons for the dismissals have included basic scientific errors such as failure of the expert to consider all possible explanations for an observed phenomenon, the selective use of data by the expert, and the failure to acknowledge and resolve inconsistencies between the expert's results and those of other investigators. This paper reviews the Daubert criteria as they apply to radiation litigation and provides examples of the application of the criteria from recent judgments involving the Three Mile Island and Hanford Downwinders cases. PMID:11725885

  13. New diagnostic criteria for neurocysticercosis: Reliability and validity

    PubMed Central

    Fleury, Agnès; Romo, Matthew L.; Abraham, Ronaldo; Fandiño, Jaime; Durán, Juan C.; Cárdenas, Graciela; Moncayo, Jorge; Leite Rodrigues, Cleonísio; San‐Juan, Daniel; Serrano‐Dueñas, Marcos; Takayanagui, Oswaldo; Sander, Josemir W.

    2016-01-01

    Objective The diagnosis of neurocysticercosis (NCC) remains problematic because of the heterogeneity of its clinical, immunological, and imaging characteristics. Our aim was to develop and assess a new set of diagnostic criteria for NCC, which might allow for the accurate detection of, and differentiation between, parenchymal and extraparenchymal disease. Methods A group of Latin American NCC experts developed by consensus a new set of diagnostic criteria for NCC. A multicenter, retrospective study was then conducted to validate it. The reference standard for diagnosis of active NCC was the disappearance or reduction of cysts after anthelmintic treatment. In total, three pairs of independent neurologists blinded to the diagnosis evaluated 93 cases (with NCC) and 93 controls (without NCC) using the new diagnostic criteria. Mixed‐effects logistic regression models were used to estimate sensitivity and specificity. Results Inter‐rater reliability (kappa) of diagnosis among evaluators was 0.60. For diagnosis of NCC versus no NCC, the new criteria had a sensitivity of 93.2% and specificity of 81.4%. For parenchymal NCC, the new criteria had a sensitivity of 89.8% and specificity of 80.7% and for extraparenchymal NCC, the new criteria had a sensitivity of 65.9% and specificity of 94.9%. Interpretation These criteria have acceptable reliability and validity and could be a new tool for clinicians and researchers. An advantage of the new criteria is that they consider parasite location (ie, parenchymal or extraparenchymal), which is an important factor determining the clinical, immunological, and radiological presentation of the disease, and importantly, its treatment and prognosis. Ann Neurol 2016;80:434–442 PMID:27438337

  14. Launch Commit Criteria Monitoring Agent

    NASA Technical Reports Server (NTRS)

    Semmel, Glenn S.; Davis, Steven R.; Leucht, Kurt W.; Rowe, Dan A.; Kelly, Andrew O.; Boeloeni, Ladislau

    2005-01-01

    The Spaceport Processing Systems Branch at NASA Kennedy Space Center has developed and deployed a software agent to monitor the Space Shuttle's ground processing telemetry stream. The application, the Launch Commit Criteria Monitoring Agent, increases situational awareness for system and hardware engineers during Shuttle launch countdown. The agent provides autonomous monitoring of the telemetry stream, automatically alerts system engineers when predefined criteria have been met, identifies limit warnings and violations of launch commit criteria, aids Shuttle engineers through troubleshooting procedures, and provides additional insight to verify appropriate troubleshooting of problems by contractors. The agent has successfully detected launch commit criteria warnings and violations on a simulated playback data stream. Efficiency and safety are improved through increased automation.

  15. Acceptability of reactors in space

    SciTech Connect

    Buden, D.

    1981-01-01

    Reactors are the key to our future expansion into space. However, there has been some confusion in the public as to whether they are a safe and acceptable technology for use in space. The answer to these questions is explored. The US position is that when reactors are the preferred technical choice, that they can be used safely. In fact, it does not appear that reactors add measurably to the risk associated with the Space Transportation System.

  16. Acceptability of reactors in space

    SciTech Connect

    Buden, D.

    1981-04-01

    Reactors are the key to our future expansion into space. However, there has been some confusion in the public as to whether they are a safe and acceptable technology for use in space. The answer to these questions is explored. The US position is that when reactors are the preferred technical choice, that they can be used safely. In fact, it dies not appear that reactors add measurably to the risk associated with the Space Transportation System.

  17. 48 CFR 12.402 - Acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acceptance. 12.402 Section... Acceptance. (a) The acceptance paragraph in 52.212-4 is based upon the assumption that the Government will rely on the contractor's assurances that the commercial item tendered for acceptance conforms to...

  18. Cyberbullying: the challenge to define.

    PubMed

    Langos, Colette

    2012-06-01

    Cyberbullying is a reality of the digital age. To address this phenomenon, it becomes imperative to understand exactly what cyberbullying is. Thus, establishing a workable and theoretically sound definition is essential. This article contributes to the existing literature in relation to the definition of cyberbullying. The specific elements of repetition, power imbalance, intention, and aggression, regarded as essential criteria of traditional face-to-face bullying, are considered in the cyber context. It is posited that the core bullying elements retain their importance and applicability in relation to cyberbullying. The element of repetition is in need of redefining, given the public nature of material in the online environment. In this article, a clear distinction between direct and indirect cyberbullying is made and a model definition of cyberbullying is offered. Overall, the analysis provided lends insight into how the essential bullying elements have evolved and should apply in our parallel cyber universe.

  19. Trust, Isolation, and Presence: The Virtual Work Environment and Acceptance of Deep Organizational Change

    ERIC Educational Resources Information Center

    Rose, Laurence Michael

    2013-01-01

    The primary focus of this research was to explore through the use of a grounded theory methodology if the human perceptions of trust, isolation, and presence affected the virtual workers ability to accept deep organizational change. The study found that the virtual workers in the sample defined their acceptance of deep organizational change by…

  20. Defining the Polar Field Reversal

    NASA Technical Reports Server (NTRS)

    Upton, Lisa; Hathaway, David H.

    2013-01-01

    The polar fields on the Sun are directly related to solar cycle variability. Recently there has been interest in studying an important characteristic of the polar fields: the timing of the polar field reversals. However this characteristic has been poorly defined, mostly due to the limitations of early observations. In the past, the reversals have been calculated by averaging the flux above some latitude (i.e. 55deg or 75deg). Alternatively, the reversal could be defined by the time in which the previous polarity is completely canceled and replaced by the new polarity at 90de, precisely at the pole. We will use a surface flux transport model to illustrate the differences in the timing of the polar field reversal based on each of these definitions and propose standardization in the definition of the polar field reversal. The ability to predict the timing of the polar field reversal using a surface flux transport model will also be discussed.

  1. How do people define moderation?

    PubMed

    vanDellen, Michelle R; Isherwood, Jennifer C; Delose, Julie E

    2016-06-01

    Eating in moderation is considered to be sound and practical advice for weight maintenance or prevention of weight gain. However, the concept of moderation is ambiguous, and the effect of moderation messages on consumption has yet to be empirically examined. The present manuscript examines how people define moderate consumption. We expected that people would define moderate consumption in ways that justified their current or desired consumption rather than view moderation as an objective standard. In Studies 1 and 2, moderate consumption was perceived to involve greater quantities of an unhealthy food (chocolate chip cookies, gummy candies) than perceptions of how much one should consume. In Study 3, participants generally perceived themselves to eat in moderation and defined moderate consumption as greater than their personal consumption. Furthermore, definitions of moderate consumption were related to personal consumption behaviors. Results suggest that the endorsement of moderation messages allows for a wide range of interpretations of moderate consumption. Thus, we conclude that moderation messages are unlikely to be effective messages for helping people maintain or lose weight. PMID:26964691

  2. How do people define moderation?

    PubMed

    vanDellen, Michelle R; Isherwood, Jennifer C; Delose, Julie E

    2016-06-01

    Eating in moderation is considered to be sound and practical advice for weight maintenance or prevention of weight gain. However, the concept of moderation is ambiguous, and the effect of moderation messages on consumption has yet to be empirically examined. The present manuscript examines how people define moderate consumption. We expected that people would define moderate consumption in ways that justified their current or desired consumption rather than view moderation as an objective standard. In Studies 1 and 2, moderate consumption was perceived to involve greater quantities of an unhealthy food (chocolate chip cookies, gummy candies) than perceptions of how much one should consume. In Study 3, participants generally perceived themselves to eat in moderation and defined moderate consumption as greater than their personal consumption. Furthermore, definitions of moderate consumption were related to personal consumption behaviors. Results suggest that the endorsement of moderation messages allows for a wide range of interpretations of moderate consumption. Thus, we conclude that moderation messages are unlikely to be effective messages for helping people maintain or lose weight.

  3. Hepatocellular carcinoma beyond Milan criteria: Management and transplant selection criteria.

    PubMed

    Elshamy, Mohammed; Aucejo, Federico; Menon, K V Narayanan; Eghtesad, Bijan

    2016-07-28

    Liver transplantation (LT) for hepatocellular carcinoma (HCC) has been established as a standard treatment in selected patients for the last two and a half decades. After initially dismal outcomes, the Milan criteria (MC) (single HCC ≤ 5 cm or up to 3 HCCs ≤ 3 cm) have been adopted worldwide to select HCC patients for LT, however cumulative experience has shown that MC can be too strict. This has led to the development of numerous expanded criteria worldwide. Morphometric expansions on MC as well as various criteria which incorporate biomarkers as surrogates of tumor biology have been described. HCC that presents beyond MC initially can be downstaged with locoregional therapy (LRT). Post-LRT monitoring aims to identify candidates with favorable tumor behavior. Similarly, tumor marker levels as response to LRT has been utilized as surrogate of tumor biology. Molecular signatures of HCC have also been correlated to outcomes; these have yet to be incorporated into HCC-LT selection criteria formally. The ongoing discrepancy between organ demand and supply makes patient selection the most challenging element of organ allocation. Further validation of extended HCC-LT criteria models and pre-LT treatment strategies are required. PMID:27478537

  4. Hepatocellular carcinoma beyond Milan criteria: Management and transplant selection criteria

    PubMed Central

    Elshamy, Mohammed; Aucejo, Federico; Menon, K V Narayanan; Eghtesad, Bijan

    2016-01-01

    Liver transplantation (LT) for hepatocellular carcinoma (HCC) has been established as a standard treatment in selected patients for the last two and a half decades. After initially dismal outcomes, the Milan criteria (MC) (single HCC ≤ 5 cm or up to 3 HCCs ≤ 3 cm) have been adopted worldwide to select HCC patients for LT, however cumulative experience has shown that MC can be too strict. This has led to the development of numerous expanded criteria worldwide. Morphometric expansions on MC as well as various criteria which incorporate biomarkers as surrogates of tumor biology have been described. HCC that presents beyond MC initially can be downstaged with locoregional therapy (LRT). Post-LRT monitoring aims to identify candidates with favorable tumor behavior. Similarly, tumor marker levels as response to LRT has been utilized as surrogate of tumor biology. Molecular signatures of HCC have also been correlated to outcomes; these have yet to be incorporated into HCC-LT selection criteria formally. The ongoing discrepancy between organ demand and supply makes patient selection the most challenging element of organ allocation. Further validation of extended HCC-LT criteria models and pre-LT treatment strategies are required. PMID:27478537

  5. A proposed acceptance process for commercial off-the-shelf (COTS) software in reactor applications

    SciTech Connect

    Preckshot, G.G.; Scott, J.A.

    1996-03-01

    This paper proposes a process for acceptance of commercial off-the-shelf (COTS) software products for use in reactor systems important to safety. An initial set of four criteria establishes COTS software product identification and its safety category. Based on safety category, three sets of additional criteria, graded in rigor, are applied to approve/disapprove the product. These criteria fall roughly into three areas: product assurance, verification of safety function and safety impact, and examination of usage experience of the COTS product in circumstances similar to the proposed application. A report addressing the testing of existing software is included as an appendix.

  6. Hazardous waste site remediation and community acceptance: Beyond regulatory compliance

    SciTech Connect

    Howard, M.A.; Moreau, J.P.

    1998-12-31

    Community acceptance is an important criteria in securing regulatory approval of remediation alternatives, and yet the legal requirements for public consultation during the preparation of site investigation and feasibility study reports are minimal. Usually the only provision for formal public input on remedial plans is at the final stages of preparation through the formalistic constraints of a public meeting and limited comment period. This is often too late for meaningful public input and precludes constructive dialogue between responsible parties, local citizens, and regulatory representatives. Often the public opposes proposed remediation alternatives because of insufficient information leading to mistrust and irreconcilable differences. This paper suggests that responsible parties run the risk of community rejection of remediation plans, and costly project delays, if they follow the minimum regulatory requirements for public involvement. Through the use of active and meaningful citizen participation throughout project planning, success in securing community acceptance for preferred remedial alternatives in potentially controversial remediation projects is greatly enhanced.

  7. Acceptance test report for portable exhauster POR-007/Skid E

    SciTech Connect

    Kriskovich, J.R.

    1998-07-24

    This document describes Acceptance Testing performed on Portable Exhauster POR-007/Skid E. It includes measurements of bearing vibration levels, pressure decay testing, programmable logic controller interlocks, high vacuum, flow and pressure control functional testing. The purpose of Acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-0490, Rev. 1 following a repair and upgrade effort at Hanford. In addition, data obtained during this testing is required for the resolution of outstanding Non-conformance Reports (NCR), and finally, to demonstrate the functionality of the associated software for the pressure control and high vacuum exhauster operating modes provided for by W-320. Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information (system curve). Results of this testing are also captured within this document.

  8. 30 CFR 942.762 - Criteria for designating areas as unsuitable for surface coal mining operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... WITHIN EACH STATE TENNESSEE § 942.762 Criteria for designating areas as unsuitable for surface coal... to the lands defined as fragile lands in § 762.5 of this chapter, the Office in evaluating...

  9. The Development of Criteria for Industrial Arts in the Public Secondary Schools and its Application to South Dakota Schools.

    ERIC Educational Resources Information Center

    Burroughs, Marvin George

    A total of 168 South Dakota industrial arts teachers (83 percent) returned questionnaires which were designed to survey public secondary school industrial arts programs and compare them with developed evaluative criteria. The findings were: (1) Industrial arts teachers accepted the philosophy and the objectives as stated in the criteria, (2)…

  10. Seismic design and evaluation criteria based on target performance goals

    SciTech Connect

    Murray, R.C.; Nelson, T.A.; Kennedy, R.P.; Short, S.A.

    1994-04-01

    The Department of Energy utilizes deterministic seismic design/evaluation criteria developed to achieve probabilistic performance goals. These seismic design and evaluation criteria are intended to apply equally to the design of new facilities and to the evaluation of existing facilities. In addition, the criteria are intended to cover design and evaluation of buildings, equipment, piping, and other structures. Four separate sets of seismic design/evaluation criteria have been presented each with a different performance goal. In all these criteria, earthquake loading is selected from seismic hazard curves on a probabilistic basis but seismic response evaluation methods and acceptable behavior limits are deterministic approaches with which design engineers are familiar. For analytical evaluations, conservatism has been introduced through the use of conservative inelastic demand-capacity ratios combined with ductile detailing requirements, through the use of minimum specified material strengths and conservative code capacity equations, and through the use of a seismic scale factor. For evaluation by testing or by experience data, conservatism has been introduced through the use of an increase scale factor which is applied to the prescribed design/evaluation input motion.

  11. 34 CFR 425.21 - What selection criteria does the Secretary use?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Secretary for review by the Department's Program Effectiveness Panel as defined in 34 CFR 400.4(b). (e... qualifications of key personnel that pertain to the quality of the project. (g) Budget and cost effectiveness... criteria does the Secretary use? The Secretary uses the following criteria to evaluate an application:...

  12. A Report to Congress on the Evaluation of Health Manpower Shortage Area Criteria.

    ERIC Educational Resources Information Center

    Health Resources Administration (DHHS/PHS), Hyattsville, MD. Bureau of Health Professions.

    This report evaluates current health manpower shortage area (HMSA) designation criteria against defined standards and program objectives, assesses possible alternatives and improvements to those criteria, and examines possible approaches to, and feasibility, of measuring demand and predicting the likelihood that unmet demand in an area will be met…

  13. Preliminary criticality study supporting transuranic waste acceptance into the plasma hearth process

    SciTech Connect

    Slate, L.J.; Santee, G.E. Jr.

    1996-12-31

    This study documents preliminary scoping calculations to address criticality issues associated with the processing of transuranic (TRU) waste and TRU mixed waste in the Plasma Hearth Process (PHP) Test Project. To assess the criticality potential associated with processing TRU waste, the process flow in the PHP is evaluated to identify the stages where criticality could occur. A criticality analysis methodology is then formulated to analyze the criticality potential. Based on these analyses, TRU acceptance criteria can be defined for the PHP. For the current level of analysis, the methodology only assesses the physical system as designed and does not address issues associated with the criticality double contingency principle. The analyses suggest that criticality within the PHP system and within the planned treatment residue (stag) containers does not pose a criticality hazard even when processing waste feed drums containing a quantity of TRU greater than would be reasonably expected. The analyses also indicate that the quantity of TRU that can be processed during each batch is controlled by moving and storage conditions for the resulting slag collection drums.

  14. The J-2X Fuel Turbopump - Turbine Nozzle Low Cycle Fatigue Acceptance Rationale

    NASA Technical Reports Server (NTRS)

    Hawkins, Lakiesha V.; Duke, Gregory C.; Newman, Wesley R.; Reynolds, David C.

    2011-01-01

    The J-2X Fuel Turbopump (FTP) turbine, which drives the pump that feeds hydrogen to the J-2X engine for main combustion, is based on the J-2S design developed in the early 1970 s. Updated materials and manufacturing processes have been incorporated to meet current requirements. This paper addresses an analytical concern that the J-2X Fuel Turbine Nozzle Low Cycle Fatigue (LCF) analysis did not meet safety factor requirements per program structural assessment criteria. High strains in the nozzle airfoil during engine transients were predicted to be caused by thermally induced stresses between the vane hub, vane shroud, and airfoil. The heritage J-2 nozzle was of a similar design and experienced cracks in the same area where analysis predicted cracks in the J-2X design. Redesign options that did not significantly impact the overall turbine configuration were unsuccessful. An approach using component tests and displacement controlled fracture mechanics analysis to evaluate LCF crack initiation and growth rate was developed. The results of this testing and analysis were used to define the level of inspection on development engine test units. The programmatic impact of developing crack initiation/growth rate/arrest data was significant for the J-2X program. Final Design Certification Review acceptance logic will ultimately be developed utilizing this test and analytical data.

  15. Quality criteria for water, 1986

    SciTech Connect

    Not Available

    1986-05-01

    Section 304(a) (1) of the Clean Water Act 33 U.S.C. 1314(a) (1) requires the Environmental Protection Agency (EPA) to publish and periodically update ambient water-quality criteria. These criteria are to accurately reflect the latest scientific knowledge (a) on the kind and extent of all identifiable effects on health and welfare including, but not limited to, plankton, fish shellfish, wildlife, plant life, shorelines, beaches, aesthetics, and recreation that may be expected from the presence of pollutants in any body of water including ground water; (b) on the concentration and dispersal of pollutants, or their byproducts, through biological, physical, and chemical processes; and (c) on the effects of pollutants on biological community diversity, productivity, and stability, including information on the factors affecting rates of eutrophication and organic and inorganic sedimentation for varying types of receiving waters. In a continuing effort to provide those who use EPA's water-quality and human-health criteria with up-to-date criteria values and associated information, the document was assembled. The document includes summaries of all the contaminants for which EPA has developed criteria recommendations.

  16. Evaluating the laws defining blindness.

    PubMed

    Hoppe, E

    1992-06-01

    The law defining legal blindness was written in 1935, and has not been updated since. A historical view of the background in the development of this law and a comparison to laws used in other countries helps to point out some problems with the current definition. As the population gets older, the prevalence of visual impairment will be increasing. To administer programs, distribute funding, and ensure adequate care, the problems inherent in the definition of legal blindness must be addressed, and the law must be revised. PMID:1634739

  17. Maintainability design criteria for packaging of spacecraft replaceable electronic equipment.

    NASA Technical Reports Server (NTRS)

    Kappler, J. R.; Folsom, A. B.

    1972-01-01

    Maintainability must be designed into long-duration spacecraft and equipment to provide the required high probability of mission success with the least cost and weight. The ability to perform repairs quickly and easily in a space environment can be achieved by imposing specific maintainability design criteria on spacecraft equipment design and installation. A study was funded to investigate and define design criteria for electronic equipment that would permit rapid removal and replacement in a space environment. The results of the study are discussed together with subsequent simulated zero-g demonstration tests of a mockup with new concepts for packaging.

  18. A systematic review of patient acceptance of consumer health information technology.

    PubMed

    Or, Calvin K L; Karsh, Ben-Tzion

    2009-01-01

    A systematic literature review was performed to identify variables promoting consumer health information technology (CHIT) acceptance among patients. The electronic bibliographic databases Web of Science, Business Source Elite, CINAHL, Communication and Mass Media Complete, MEDLINE, PsycArticles, and PsycInfo were searched. A cited reference search of articles meeting the inclusion criteria was also conducted to reduce misses. Fifty-two articles met the selection criteria. Among them, 94 different variables were tested for associations with acceptance. Most of those tested (71%) were patient factors, including sociodemographic characteristics, health- and treatment-related variables, and prior experience or exposure to computer/health technology. Only ten variables were related to human-technology interaction; 16 were organizational factors; and one was related to the environment. In total, 62 (66%) were found to predict acceptance in at least one study. Existing literature focused largely on patient-related factors. No studies examined the impact of social and task factors on acceptance, and few tested the effects of organizational or environmental factors on acceptance. Future research guided by technology acceptance theories should fill those gaps to improve our understanding of patient CHIT acceptance, which in turn could lead to better CHIT design and implementation. PMID:19390112

  19. Development of reclaimed potable water quality criteria

    NASA Technical Reports Server (NTRS)

    Flory, D. A.; Weir, F. W.

    1979-01-01

    In order to minimize launch requirements necessary to meet the demands of long-term spaceflight, NASA will reuse water reclaimed from various on-board sources including urine, feces, wash water and humidity condensate. Development of reclamation systems requires the promulgation of water quality standards for potable reuse of the reclaimed water. Existing standards for domestic U.S. potable water consumption were developed, but do not consider the peculiar problems associated with the potable reuse of recycled water. An effort was made to: (1) define a protocol by which comprehensive reclaimed water potability/palatability criteria can be established and updated; and (2) continue the effort to characterize the organic content of reclaimed water in the Regenerative Life Support Evaluation.

  20. Tensile failure criteria for fiber composite materials

    NASA Technical Reports Server (NTRS)

    Rosen, B. W.; Zweben, C. H.

    1972-01-01

    The analysis provides insight into the failure mechanics of these materials and defines criteria which serve as tools for preliminary design material selection and for material reliability assessment. The model incorporates both dispersed and propagation type failures and includes the influence of material heterogeneity. The important effects of localized matrix damage and post-failure matrix shear stress transfer are included in the treatment. The model is used to evaluate the influence of key parameters on the failure of several commonly used fiber-matrix systems. Analyses of three possible failure modes were developed. These modes are the fiber break propagation mode, the cumulative group fracture mode, and the weakest link mode. Application of the new model to composite material systems has indicated several results which require attention in the development of reliable structural composites. Prominent among these are the size effect and the influence of fiber strength variability.