78 FR 72006 - Establishment of Class D Airspace and Class E Airspace; Laguna AAF, AZ

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... establishes Class D airspace and Class E airspace at Laguna Army Air Field (AAF), (Yuma Proving Ground), Yuma...) within a 3.5- mile radius of Laguna AAF (Yuma Proving Ground), Yuma, AZ; and Class E airspace extending... scope of that authority as it establishes controlled airspace at Laguna AAF, (Yuma Proving Ground), Yuma...

Sorption kinetics, isotherms, and mechanism of aniline aerofloat to agricultural soils with various physicochemical properties.

PubMed

Xiang, Lei; Xiao, Tao; Mo, Ce-Hui; Zhao, Hai-Ming; Li, Yan-Wen; Li, Hui; Cai, Quan-Ying; Zhou, Dong-Mei; Wong, Ming-Hung

2018-06-15

Aniline aerofloat (AAF), a high-toxic organic flotation reagent, is widely used in mineral processing industry. However, little information on its environmental fate is available. AAF sorption to four types of agricultural soils at low concentrations (1-10 mg/L) was investigated using batch experiments. AAF sorption kinetics involved both boundary layer diffusion and intraparticle diffusion, following pseudo-second-order kinetics with equilibrium time within 120 min. Both Langmuir and Freundlich models fitted well the AAF sorption with the former better. Sorption of AAF to soils was a spontaneous and favorable physical sorption that was controlled by ion bridge effect and hydrophobic interaction that was related to van der Waals force and π-π coordination based on FTIR analyses. AAF sorption was remarkably affected by soil constituents, positively correlating with the contents of organic matter and clay. The relatively higher logK oc values (3.53-4.66) of AAF at environmental concentrations (1-5 mg/L) imply that soils are serving as a sink of AAF from beneficiation wastewater, posing great potential risks to environment and human health. Copyright © 2018 Elsevier Inc. All rights reserved.

76 FR 14421 - Section 8 Housing Assistance Payments Program-Contract Rent Annual Adjustment Factors (AAFs...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... contract rent is reduced by comparability): The Table 1 Contract Rent AAF is used for a unit occupied by a... be reduced below the contract rent on the effective date of the HAP contract. III. When To Use Reduced AAFs (From AAF Table 2) In accordance with Section 8(c)(2)(A) of the United States Housing Act of...

76 FR 27084 - Section 8 Housing Assistance Payments Program-Renewal Funding Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-10

... the Federal Register on March 16, 2011, and can be viewed at: http://www.huduser.org/portal/datasets.../datasets/aaf/FY2011_RF_table.pdf . Renewal Funding AAFs include utility costs and only one set of AAFs is.../portal/datasets/aaf/FY2011_AreaDef.pdf . For units located in metropolitan areas with a local CPI survey...

Real-time dosimeter employed to evaluate the half-value layer in CT

NASA Astrophysics Data System (ADS)

McKenney, Sarah E.; Seibert, J. Anthony; Burkett, George W.; Gelskey, Dale; Sunde, Paul B.; Newman, James D.; Boone, John M.

2014-01-01

Half-value layer (HVL) measurements on commercial whole body computer tomography (CT) scanners require serial measurements and, in many institutions, the presence of a service engineer. An assembly of aluminum filters (AAF), designed to be used in conjunction with a real-time dosimeter, was developed to provide estimates of the HVL using clinical protocols. Two real-time dose probes, a solid-state and air ionization chamber, were examined. The AAF consisted of eight rectangular filters of high-purity aluminum (Type 1100), symmetrically positioned to form a cylindrical ‘cage’ around the probe's detective volume. The incident x-ray beam was attenuated by varying thicknesses of aluminum filters as the gantry completed a minimum of one rotation. Measurements employing real-time chambers were conducted both in service mode and with a routine abdomen/pelvis protocol for several combinations of x-ray tube potentials and bow tie filters. These measurements were validated against conventional serial HVL measurements. The average relative difference between the HVL measurements using the two methods was less than 5% when using a 122 mm diameter AAF; relative differences were reduced to 1.1% when the diameter was increased to 505 mm, possibly due to reduced scatter contamination. Use of a real-time dose probe and the AAF allowed for time-efficient measurements of beam quality on a clinical CT scanner using clinical protocols.

The DOE ARM Aerial Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmid, Beat; Tomlinson, Jason M.; Hubbe, John M.

2014-05-01

The Department of Energy Atmospheric Radiation Measurement (ARM) Program is a climate research user facility operating stationary ground sites that provide long-term measurements of climate relevant properties, mobile ground- and ship-based facilities to conduct shorter field campaigns (6-12 months), and the ARM Aerial Facility (AAF). The airborne observations acquired by the AAF enhance the surface-based ARM measurements by providing high-resolution in-situ measurements for process understanding, retrieval-algorithm development, and model evaluation that are not possible using ground- or satellite-based techniques. Several ARM aerial efforts were consolidated into the AAF in 2006. With the exception of a small aircraft used for routinemore » measurements of aerosols and carbon cycle gases, AAF at the time had no dedicated aircraft and only a small number of instruments at its disposal. In this "virtual hangar" mode, AAF successfully carried out several missions contracting with organizations and investigators who provided their research aircraft and instrumentation. In 2009, AAF started managing operations of the Battelle-owned Gulfstream I (G-1) large twin-turboprop research aircraft. Furthermore, the American Recovery and Reinvestment Act of 2009 provided funding for the procurement of over twenty new instruments to be used aboard the G-1 and other AAF virtual-hangar aircraft. AAF now executes missions in the virtual- and real-hangar mode producing freely available datasets for studying aerosol, cloud, and radiative processes in the atmosphere. AAF is also engaged in the maturation and testing of newly developed airborne sensors to help foster the next generation of airborne instruments.« less

An Analysis of AAFES and Its Relevance to the Future of the Army and Air Force

DTIC Science & Technology

2009-06-12

benefits of this organization and are there any viable alternatives? Background and Significance AAFES provides retail goods and services to a select...relative to cost, benefit , and alternative options. Assumptions This study is based on the assumptions that AAFES and the MWR programs of the Army...AAFES is a joint Army and Air Force non-appropriated fund instrumentality (NAFI) charged with operating retail and service activities for the benefit

When Should Infants with Cow's Milk Protein Allergy Use an Amino Acid Formula? A Practical Guide.

PubMed

Meyer, Rosan; Groetch, Marion; Venter, Carina

Cow's milk protein allergy (CMPA) is the most common food allergy in childhood and its prevalence ranges between 1.9% and 4.9%. Most children present with CMPA at age less than 1 year and therefore may require a hypoallergenic formula in the absence of breast milk. Hypoallergenic formulas include both extensively hydrolyzed formula (EHF) and amino acid formula (AAF). For most children with a CMPA, an EHF will be sufficient for symptom resolution, as reflected in current guidelines, but there is a subset of children with CMPA where an AAF may be indicated. The appropriate use of an AAF is a highly debated topic, because there is a significant fiscal burden to either the health care system or the parents. From the literature, the following themes were identified as possible reasons for choosing an AAF: (1) symptoms not fully resolved on EHF, (2) faltering growth/failure to thrive, (3) multiple food eliminations, (4) severe complex gastrointestinal food allergies, (5) eosinophilic esophagitis, (6) food protein-induced enterocolitis syndrome, (7) severe eczema, and (8) symptoms while breast-feeding. Each of these themes was critically reviewed using all available published data and found that using an AAF in height growth faltering may be indicated. In addition, patients who end up on an AAF often present with multisystem involvement, requiring multiple food eliminations and fall within the more severe spectrum of gastrointestinal allergies. In eosinophilic esophagitis, all current recommendations support the use of an AAF as first-line approach, and in children with anaphylaxis, despite limited evidence an AAF is recommended because of the potential risk for a severe reaction. The use of an AAF in children who are breast-fed remains a highly controversial topic and at all times breast-feeding should be supported in children with CMPA. This article provides a practical guide that is evidence based for health care professionals to the use of AAF. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. All rights reserved.

The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review.

PubMed

Hill, D J; Murch, S H; Rafferty, K; Wallis, P; Green, C J

2007-06-01

The aim of this systematic review was to evaluate the efficacy of amino acid-based formulas (AAF) in patients with cow's milk allergy (CMA). Studies were identified using electronic databases and bibliography searches. Subjects eligible for inclusion were patients of any age with CMA or symptoms suggestive of it. Comparisons of interest were AAF vs. extensively hydrolysed formula (eHF), AAF vs. soy-based formula (SF) and AAF vs. cow's milk or cow's milk-based formula. Outcomes of interest were gastrointestinal (GI), dermatological, respiratory and behavioural symptoms as well as growth. A total of 20 studies [three head-to-head randomized controlled trials (RCTs), three cross-over challenge RCTs, seven clinical trials (CTs) and seven case reports (CRs)] were included in the review. In infants with confirmed or suspected CMA, the use of an AAF was shown to be safe and efficacious. Findings from RCT comparisons of AAF with eHF showed that both formulas are equally efficacious at relieving the symptoms of CMA in confirmed or suspected cases. However, infants in specific subgroups (e.g. non-IgE mediated food-induced gastro-enterocolitis-proctitis syndromes with failure to thrive, severe atopic eczema, or with symptoms during exclusive breastfeeding) were more likely overall to benefit from AAF, as intolerance to eHF may occur. In such cases, symptoms persisting despite eHF feeding usually remit on AAF, and catch-up growth may be seen. Meta-analysis of the findings was not possible due to lack of homogenous reporting of outcomes in the original trials. This systematic review shows clinical benefit from use of AAF in both symptoms and growth in infants and children with CMA who fail to tolerate eHF. Further studies are required to determine the relative medical or economic value of initial treatment with AAF in infants at high risk of eHF intolerance.

Structural characterization of anti-complementary polysaccharides from the leaves of Artemisia princeps.

PubMed

Yamada, H; Otsuka, Y; Omura, S

1986-08-01

Structural characterizations of the anti-complementary acidic heteroglycans, AAF IIb-2 and IIb-3, obtained from the leaves of Artemisia princeps pamp have been studied. AAF IIb-2 consists of rhamnose, xylose, arabinose, galactose, glucose and uronic acids (glucuronic acid and galacturonic acid) in the molar ratio of 7.6:7.6:13.0:10.9:3.0:57.9, and AAF IIb-3 consists of the same sugars in the ratio of 3.9:2.6:24.7:19.7:2.6:46.5. Methylation analysis including carboxyl-reduction and also selective enzymolysis using EXO-alpha- L-arabinofuranosidase suggested that AAF IIb-3 has a main chain consisting of (1-->4)-linked galacturonic acid and (1-->2)-linked rhamnose mostly substituted at the O-4 position. AAF IIb-3 also contained arabino-3,6-galactan moiety and most of the arabinose was present as an alpha- L-furanosyl residue in the non-reducing terminals and highly branched side chains which mostly attached to the O-3 position of (1-->6)-linked galactopyranosyl residue. The basic structure of AAF IIb-2 is similar to that of AAF IIb-3, but IIb-3 has a higher arabinogalactan content than IIb-2.

Environmental Assessment: Proposed Construction of Army and Air Force Exchange Service New Day Street Shoppette

DTIC Science & Technology

2003-10-01

would either be operated by AAFES as a franchise or would be owned by AAFES. The three existing 10,000-gallon underground storage tanks (USTs...Street Shoppette FINAL Army and Air Force Exchange Service 2-3 The restaurant would either be operated by AAFES as a franchise or would be owned by...levels of employment with the inclusion of a new restaurant, (to be either a franchise or AAFES-owned), car wash, increased services of the Auto Pride

Improved Tolerance to a New Amino Acid-Based Formula by Infants With Cow's Milk Protein Allergy.

PubMed

Jirapinyo, Pipop; Densupsoontorn, Narumon; Kangwanpornsiri, Channagan; Wongarn, Renu; Tirapongporn, Hathaichanok; Chotipanang, Kwanjai; Phuangphan, Phakkanan

2016-12-01

Prevalence and severity of cow's milk protein allergy (CMA) in infants are increasing. A proportion of infants with CMA still elicit signs and symptoms of CMA while ingesting commercial amino acid-based formulas (AAFs). We propose that protein in glucose polymers (GPs) derived from corn starch in the AAFs might be the cause of intolerance to AAF in some infants. We thus have produced small molecules of GPs from rice starch, eliminating the protein fraction from them, and subsequently used them as the sole source of carbohydrate in a new amino acid-based formula (NAAF). The efficacy of the NAAF was compared with that of an AAF in a double-blind, placebo-controlled food challenge (DBPCFC) in young infants with CMA aged <4 months. Infants consumed each formula for 14 days before switching to the other one. If no respiratory, dermatologic, and gastrointestinal symptom occurred, it was considered tolerance. After the challenge, infants consumed the tolerated formula for 4 weeks to prove real tolerance to that formula. Of 46 infants, 23 were intolerant to the AAF, of whom 7 (30.4%) were also intolerant to the NAAF. Sixteen of the 23 infants who were intolerant to the AAF could tolerate the NAAF ( P < .05). The minimal important difference of decreasing percentage of intolerance to the NAAF was 34.8% compared with the infants who were intolerant to the AAF. The NAAF is better tolerated than a commercially available AAF for the management of infants with CMA.

76 FR 47605 - Notice of Proposed Information Collection: Comment Request; Annual Adjustment Factors (AAF) Rent...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5484-N-26] Notice of Proposed Information Collection: Comment Request; Annual Adjustment Factors (AAF) Rent Increase Requirement AGENCY... also lists the following information: Title of Proposal: Annual Adjustment Factors (AAF) Rent Increase...

Incidence of acute-onset atrial fibrillation correlates with air temperature. Results of a nine-year survey.

PubMed

Comelli, Ivan; Ferro, Jayme; Lippi, Giuseppe; Comelli, Denis; Sartori, Elisabetta; Cervellin, Gianfranco

2014-09-01

Some diseases, such as renal colic, stroke, and myocardial infarction, correlate with seasonality and microclimatic variations. Although evidence is limited and controversial, a correlation between acute-onset atrial fibrillation (AAF) and seasonality has been previously reported. In order to elucidate the possible correlations between weather and incidence of AAF in a country with a temperate climate, the influence of day-by-day climate changes was analyzed based on the number of visits for AAF (defined as onset of symptoms within 48h) in a large urban Emergency Department (ED) of northern Italy. All the episodes of AAF were retrieved from the hospital's electronic database during a period of 3287days (January 2002 to December 2010). Only the cases whose onset occurred within 48h from the ED visit were selected. The total number of ED visits was 725,812 throughout the observational period. Among these, 3633 AAF cases were observed, 52% of which were males. A slight but significant negative linear correlation was found between the number of AAFs and the daily temperature (R=-0.60; p=0.001). No correlation was found between the number of AAFs and the daily humidity (R=-0.07; p=0.2). Copyright © 2014 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

Making and monitoring errors based on altered auditory feedback

PubMed Central

Pfordresher, Peter Q.; Beasley, Robertson T. E.

2014-01-01

Previous research has demonstrated that altered auditory feedback (AAF) disrupts music performance and causes disruptions in both action planning and the perception of feedback events. It has been proposed that this disruption occurs because of interference within a shared representation for perception and action (Pfordresher, 2006). Studies reported here address this claim from the standpoint of error monitoring. In Experiment 1 participants performed short melodies on a keyboard while hearing no auditory feedback, normal auditory feedback, or alterations to feedback pitch on some subset of events. Participants overestimated error frequency when AAF was present but not for normal feedback. Experiment 2 introduced a concurrent load task to determine whether error monitoring requires executive resources. Although the concurrent task enhanced the effect of AAF, it did not alter participants’ tendency to overestimate errors when AAF was present. A third correlational study addressed whether effects of AAF are reduced for a subset of the population who may lack the kind of perception/action associations that lead to AAF disruption: poor-pitch singers. Effects of manipulations similar to those presented in Experiments 1 and 2 were reduced for these individuals. We propose that these results are consistent with the notion that AAF interference is based on associations between perception and action within a forward internal model of auditory-motor relationships. PMID:25191294

Bacterial dynamics and metabolite changes in solid-state acetic acid fermentation of Shanxi aged vinegar.

PubMed

Li, Sha; Li, Pan; Liu, Xiong; Luo, Lixin; Lin, Weifeng

2016-05-01

Solid-state acetic acid fermentation (AAF), a natural or semi-controlled fermentation process driven by reproducible microbial communities, is an important technique to produce traditional Chinese cereal vinegars. Highly complex microbial communities and metabolites are involved in traditional Chinese solid-state AAF, but the association between microbiota and metabolites during this process are still poorly understood. In this study, we performed amplicon 16S rRNA gene sequencing on the Illumina MiSeq platform, PCR-denaturing gradient gel electrophoresis, and metabolite analysis to trace the bacterial dynamics and metabolite changes under AAF process. A succession of bacterial assemblages was observed during the AAF process. Lactobacillales dominated all the stages. However, Acetobacter species in Rhodospirillales were considerably accelerated during AAF until the end of fermentation. Quantitative PCR results indicated that the biomass of total bacteria showed a "system microbe self-domestication" process in the first 3 days, and then peaked at the seventh day before gradually decreasing until the end of AAF. Moreover, a total of 88 metabolites, including 8 organic acids, 16 free amino acids, and 66 aroma compounds were detected during AAF. Principal component analysis and cluster analyses revealed the high correlation between the dynamics of bacterial community and metabolites.

Functional improvement of Saccharomyces cerevisiae to reduce volatile acidity in wine.

PubMed

Luo, Zongli; Walkey, Christopher J; Madilao, Lufiani L; Measday, Vivien; Van Vuuren, Hennie J J

2013-08-01

Control of volatile acidity (VA) is a major issue for wine quality. In this study, we investigated the production of VA by a deletion mutant of the fermentation stress response gene AAF1 in the budding yeast Saccharomyces cerevisiae. Fermentations were carried out in commercial Chardonnay grape must to mimic industrial wine-making conditions. We demonstrated that a wine yeast strain deleted for AAF1 reduced acetic acid levels in wine by up to 39.2% without increasing the acetaldehyde levels, revealing a potential for industrial application. Deletion of the cytosolic aldehyde dehydrogenase gene ALD6 also reduced acetic acid levels dramatically, but increased the acetaldehyde levels by 41.4%, which is not desired by the wine industry. By comparison, ALD4 and the AAF1 paralog RSF2 had no effects on acetic acid production in wine. Deletion of AAF1 was detrimental to the growth of ald6Δ and ald4Δald6Δ mutants, but had no effect on acetic acid production. Overexpression of AAF1 dramatically increased acetic acid levels in wine in an Ald6p-dependent manner, indicating that Aaf1p regulates acetic acid production mainly via Ald6p. Overexpression of AAF1 in an ald4Δald6Δ strain produced significantly more acetic acid in wine than the ald4Δald6Δ mutant, suggesting that Aaf1p may also regulate acetic acid synthesis independently of Ald4p and Ald6p. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Mode of complement activation by acidic heteroglycans from the leaves of Artemisia princeps PAMP.

PubMed

Yamada, H; Nagai, T; Cyong, J C; Otsuka, Y

1991-08-01

The mode of action of the anti-complementary acidic heteroglycans, AAF-IIb-2 and IIb-3 which consisted of rhamnogalacturonan core and arabinogalactan moieties, purified from the leaves of Artemisia princeps PAMP (Japanese name = Gaiyo) were investigated. The anti-complementary activities of AAF-IIb-2 and IIb-3 were reduced partially in the absence of Ca2+ ions. A marked consumption of C4 was observed to have occurred when serum was incubated with both polysaccharides in the presence of Ca2+ ions. AAF-IIb-2 showed more potent C4 consumption than IIb-3. After the incubation of the serum with AAF-IIb-2 in the absence of Ca2+ ions, a cleavage of C3 in the serum was detected by immunoelectrophoresis. AAF-IIb-2 showed more significant consumption of the complement than IIb-3 when rabbit erythrocytes were used in the assay system in the absence of Ca2+ ions. These results indicate that AAF-IIb-2 activates the complement via both the alternative and classical pathways, whereas IIb-3 mainly activates the complement via the classical pathway. The absorption of serum with Protein A-Sepharose results in a decrease of the activity of AAF-IIb-2 and IIb-3. However, the decrease of the activity was restored by the replacement of the immunoglobulin G (IgG) fraction after its recovery from the Protein A-Sepharose. These results suggest that IgG dependent mechanisms are both involved in the anti-complementary activity of AAF-IIb-2 and IIb-3.

78 FR 58158 - Establishment of Class D Airspace; Bryant AAF, Anchorage, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

...-2012-0433; Airspace Docket No. 12-AAL-5] Establishment of Class D Airspace; Bryant AAF, Anchorage, AK... corrects a final rule published in the Federal Register August 8, 2013 that establishes Class D airspace at... Bryant AAF, in that the language indicating Class D airspace as part time was left out. DATES: Effective...

Alcohol-Attributable Fraction in Liver Disease: Does GDP Per Capita Matter?

PubMed

Kröner, Paul T; Mankal, Pavan Kumar; Dalapathi, Vijay; Shroff, Kavin; Abed, Jean; Kotler, Donald P

2015-01-01

The alcohol-attributable fraction (AAF) quantifies alcohol's disease burden. Alcoholic liver disease (ALD) is influenced by alcohol consumption per capita, duration, gender, ethnicity, and other comorbidities. In this study, we investigated the association between AAF/alcohol-related liver mortality and alcohol consumption per capita, while stratifying to per-capita gross domestic product (GDP). Data obtained from the World Health Organization and World Bank for both genders on AAF on liver disease, per-capita alcohol consumption (L/y), and per-capita GDP (USD/y) were used to conduct a cross-sectional study. Countries were classified as "high-income" and "very low income" if their respective per-capita GDP was greater than $30,000 or less than $1,000. Differences in total alcohol consumption per capita and AAF were calculated using a 2-sample t test. Scatterplots were generated to supplement the Pearson correlation coefficients, and F test was conducted to assess for differences in variance of ALD between high-income and very low income countries. Twenty-six and 27 countries met the criteria for high-income and very low income countries, respectively. Alcohol consumption per capita was higher in high-income countries. AAF and alcohol consumption per capita for both genders in high-income and very low income countries had a positive correlation. The F test yielded an F value of 1.44 with P = .357. No statistically significant correlation was found among alcohol types and AAF. Significantly higher mortality from ALD was found in very low income countries relative to high-income countries. Previous studies had noted a decreased AAF in low-income countries as compared to higher-income countries. However, the non-statistically significant difference between AAF variances of low-income and high-income countries was found by this study. A possible explanation is that both high-income and low-income populations will consume sufficient amount of alcohol, irrespective of its type, enough to weigh into equivalent AAF. No significant difference of AAF variance was found between high-income and very low income countries relating to sex-specific alcohol consumption per capita. Alcohol consumption per capita was greater in high-income countries. Type of preferred alcohol did not correlate with AAF. ALD related mortality was less in high-income countries as a result of better developed healthcare systems. ALD remains a significant burden globally, requiring prevention from socioeconomic, medical, and political realms. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Conceptual Model of Weight Management in Overweight and Obese African-American Females.

PubMed

Sutton, Suzanne M; Magwood, Gayenell S; Nemeth, Lynne S; Jenkins, Carolyn M

2017-04-01

Weight management of overweight and obese (OWO) African-American females (AAFs) is a poorly defined concept, leading to ineffective treatment of overweight and obesity, prevention of health sequelae, and risk reduction. A conceptual model of the phenomenon of weight management in OWO AAFs was developed through dimensional analysis of the literature. Constructs were identified and sorted into the dimensions of perspective, context, conditions, process, and consequences and integrated into an explanatory matrix. Through dimensional analysis, weight management in OWO AAFs was characterized as a multidimensional concept, defined from the perspective of weight loss in community-dwelling AAFs. Behaviors associated with weight management are strongly influenced by intrinsic factors and extrinsic conditions, which influence engagement in the processes and consequences of weight management. The resulting conceptual model of weight management in OWO AAFs provides a framework for research interventions applicable in a variety of settings. © 2016 Wiley Periodicals, Inc.

75 FR 6685 - Section 8 Housing Assistance Payments Program-Contract Rent Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... contract rent is reduced by comparability): The Table 1 Contract Rent AAF is used for a unit occupied by a... rent to owner will not be reduced below the contract rent on the effective date of the HAP contract. III. When to Use Reduced Contract Rent AAFs (From Contract Rent AAF Table 2) In accordance with...

76 FR 59713 - Notice of Submission of Proposed Information Collection to OMB Annual Adjustment Factors (AAF...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... subject proposal. Owners of project-based section 8 contracts that utilize the AAF as the method of rent.... Description of the Need for the Information and its Proposed Use: Owners of project-based section 8 contracts that utilize the AAF as the method of rent adjustment provide this information which is necessary to...

78 FR 30322 - Section 8 Housing Assistance Payments Program-Annual Adjustment Factors, Fiscal Year 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... level will be the new rent to owner. The new rent to owner will not be reduced below the contract rent on the effective date of the HAP contract. III. When to Use Reduced AAFs (From AAF Table 2) In... AAF is reduced by 0.01: For all tenancies assisted in the Section 8 Project-Based Certificate program...

A survey of Australian adult users of altered auditory feedback devices for stuttering: use patterns, perceived effectiveness and satisfaction.

PubMed

Lincoln, Michelle; Walker, Clare

2007-10-15

Small portable devices that provide delayed auditory feedback (DAF) and/or frequency altered feedback (FAF) have been developed and marketed to clinicians and people who stutter as fluency enhancing aids for use in everyday speaking situations. The literature contains many laboratory-based reports about the impact of altered auditory feedback (AAF) on the speech of people who stutter but few reports about its use in everyday speaking situations. This paper investigates use patterns and perceptions of the effectiveness and satisfaction with AAF devices. The current study surveys 14 Australian AAF users. The survey responses revealed varied opinions about AAF devices and their use and effectiveness in everyday speaking situations. Opinions were somewhat related to the type of device used. The results of this study provide some important directions for future research. In particular there is need to investigate the effectiveness of AAF devices when used in conjunction with other traditional treatments.

Geology and metallogeny of the Ar Rayn terrane, eastern Arabian shield: Evolution of a Neoproterozoic continental-margin arc during assembly of Gondwana within the East African orogen

USGS Publications Warehouse

Doebrich, J.L.; Al-Jehani, A. M.; Siddiqui, A.A.; Hayes, T.S.; Wooden, J.L.; Johnson, P.R.

2007-01-01

The Neoproterozoic Ar Rayn terrane is exposed along the eastern margin of the Arabian shield. The terrane is bounded on the west by the Ad Dawadimi terrane across the Al Amar fault zone (AAF), and is nonconformably overlain on the east by Phanerozoic sedimentary rocks. The terrane is composed of a magmatic arc complex and syn- to post-orogenic intrusions. The layered rocks of the arc, the Al Amar group (>689 Ma to ???625 Ma), consist of tholeiitic to calc-alkaline basaltic to rhyolitic volcanic and volcaniclastic rocks with subordinate tuffaceous sedimentary rocks and carbonates, and are divided into an eastern and western sequence. Plutonic rocks of the terrane form three distinct lithogeochemical groups: (1) low-Al trondhjemite-tonalite-granodiorite (TTG) of arc affinity (632-616 Ma) in the western part of the terrane, (2) high-Al TTG/adakite of arc affinity (689-617 Ma) in the central and eastern part of the terrane, and (3) syn- to post-orogenic alkali granite (607-583 Ma). West-dipping subduction along a trench east of the terrane is inferred from high-Al TTG/adakite emplaced east of low-Al TTG. The Ar Rayn terrane contains significant resources in epithermal Au-Ag-Zn-Cu-barite, enigmatic stratiform volcanic-hosted Khnaiguiyah-type Zn-Cu-Fe-Mn, and orogenic Au vein deposits, and the potential for significant resources in Fe-oxide Cu-Au (IOCG), and porphyry Cu deposits. Khnaiguiyah-type deposits formed before or during early deformation of the Al Amar group eastern sequence. Epithermal and porphyry deposits formed proximal to volcanic centers in Al Amar group western sequence. IOCG deposits are largely structurally controlled and hosted by group-1 intrusions and Al Amar group volcanic rocks in the western part of the terrane. Orogenic gold veins are largely associated with north-striking faults, particularly in and near the AAF, and are presumably related to amalgamation of the Ar Rayn and Ad Dawadimi terranes. Geologic, structural, and metallogenic characteristics of the Ar Rayn terrane are analogous to the Andean continental margin of Chile, with opposite subduction polarity. The Ar Rayn terrane represents a continental margin arc that lay above a west-dipping subduction zone along a continental block represented by the Afif composite terrane. The concentration of epithermal, porphyry Cu and IOCG mineral systems, of central arc affiliation, along the AAF suggests that the AAF is not an ophiolitic suture zone, but originated as a major intra-arc fault that localized magmatism and mineralization. West-directed oblique subduction and ultimate collision with a land mass from the east (East Gondwana?) resulted in major transcurrent displacement along the AAF, bringing the eastern part of the arc terrane to its present exposed position, juxtaposed across the AAF against a back-arc basin assemblage represented by the Abt schist of the Ad Dawadimi terrane. Our findings indicate that arc formation and accretionary processes in the Arabian shield were still ongoing into the latest Neoproterozoic (Ediacaran), to about 620-600 Ma, and lead us to conclude that evolution of the Ar Rayn terrane (arc formation, accretion, syn- to postorogenic plutonism) defines a final stage of assembly of the Gondwana supercontinent along the northeastern margin of the East African orogen. ?? 2007 Elsevier B.V. All rights reserved.

Teratogenicity in vitro of two deacetylated metabolites of N-hydroxy-2-acetylaminofluorene.

PubMed

Faustman-Watts, E M; Greenaway, J C; Namkung, M J; Fantel, A G; Juchau, M R

1984-10-01

In previous studies [E. Faustman-Watts, J. C. Greenaway, M. J. Namkung, A. G. Fantel, and M. R. Juchau (1983) Teratology 27, 19-28] an embryo culture system was utilized to investigate the role of biotransformation in the embryotoxicity of 2-acetylaminofluorene. For this investigation, the capacity of two deacetylated metabolites of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to produce malformations in cultured whole rat embryos is reported. The relative capacities of N-hydroxy-2-aminofluorene (N-OH-AF) and 2-nitrosofluorene (NF) to elicit embryotoxic effects, including embryolethality, malformations, growth retardation, and alterations in macromolecular content, were assessed and compared with effects produced by N-OH-AAF and bioactivated 2-acetylaminofluorene (AAF). Qualitatively similar patterns of malformations were produced by NF and N-OH-AF. At initial concentrations greater than 60 microM, both deacetylated compounds caused abnormalities in axial rotation (flexure), decreased viability, and decreases in embryonic DNA and protein content. Both chemicals were active in the absence of a bioactivating system. AAF produced a different spectrum of defects, and was active only in the presence of a complete monooxygenase system. The malformations produced by bioactivated AAF included abnormally open neural tubes; flexure abnormalities were rarely observed. The primary defect elicited by N-OH-AAF was prosencephalic hypoplasia. This chemical was active without an added bioactivating system. Temporal studies demonstrated that exposure of embryos to NF (128 microM) for as little as 2 hr was sufficient to elicit embryotoxic effects. None of the individual metabolites appeared to be solely responsible for the interruptions of neural tube closure produced by bioactivated AAF.

Alcohol-Adapted Anger Management Treatment: A Randomized Controlled Trial of an Innovative Therapy for Alcohol Dependence.

PubMed

Walitzer, Kimberly S; Deffenbacher, Jerry L; Shyhalla, Kathleen

2015-12-01

A randomized controlled trial for an innovative alcohol-adapted anger management treatment (AM) for outpatient alcohol dependent individuals scoring moderate or above on anger is described. AM treatment outcomes were compared to those of an empirically-supported intervention, Alcoholics Anonymous Facilitation treatment (AAF). Clients in AM, relative to clients in AAF, were hypothesized to have greater improvement in anger and anger-related cognitions and lesser AA involvement during the 6-month follow-up. Anger-related variables were hypothesized to be stronger predictors of improved alcohol outcomes in the AM treatment condition and AA involvement was hypothesized to be a stronger predictor of alcohol outcomes in the AAF treatment group. Seventy-six alcohol dependent men and women were randomly assigned to treatment condition and followed for 6 months after treatment end. Both AM and AAF treatments were followed by significant reductions in heavy drinking days, alcohol consequences, anger, and maladaptive anger-related thoughts and increases in abstinence and self-confidence regarding not drinking to anger-related triggers. Treatment with AAF was associated with greater AA involvement relative to treatment with AM. Changes in anger and AA involvement were predictive of posttreatment alcohol outcomes for both treatments. Change in trait anger was a stronger predictor of posttreatment alcohol consequences for AM than for AAF clients; during-treatment AA meeting attendance was a stronger predictor of posttreatment heavy drinking and alcohol consequences for AAF than for AM clients. Anger-related constructs and drinking triggers should be foci in treatment of alcohol dependence for anger-involved clients. Copyright © 2015 Elsevier Inc. All rights reserved.

Alcohol-adapted Anger Management Treatment: A Randomized Controlled Trial of an Innovative Therapy for Alcohol Dependence

PubMed Central

Walitzer, Kimberly S.; Deffenbacher, Jerry L.; Shyhalla, Kathleen

2015-01-01

A randomized controlled trial for an innovative alcohol-adapted anger management treatment (AM) for outpatient alcohol dependent individuals scoring moderate or above on anger is described. AM treatment outcomes were compared to those of an empirically-supported intervention, Alcoholics Anonymous Facilitation treatment (AAF). Clients in AM, relative to clients in AAF, were hypothesized to have greater improvement in anger and anger-related cognitions and lesser AA involvement during the six-month follow-up. Anger-related variables were hypothesized to be stronger predictors of improved alcohol outcomes in the AM treatment condition and AA involvement was hypothesized to be a stronger predictor of alcohol outcomes in the AAF treatment group. Seventy-six alcohol dependent men and women were randomly assigned to treatment condition and followed for six months after treatment end. Both AM and AAF treatments were followed by significant reductions in heavy drinking days, alcohol consequences, anger, and maladaptive anger-related thoughts and increases in abstinence and self-confidence regarding not drinking to anger-related triggers. Treatment with AAF was associated with greater AA involvement relative to treatment with AM. Changes in anger and AA involvement were predictive of posttreatment alcohol outcomes for both treatments. Change in trait anger was a stronger predictor of posttreatment alcohol consequences for AM than for AAF clients; during-treatment AA meeting attendance was a stronger predictor of posttreatment heavy drinking and alcohol consequences for AAF than for AM clients. Anger-related constructs and drinking triggers should be foci in treatment of alcohol dependence for anger-involved clients. PMID:26387049

Ameliorative effects of Artemisia argyi Folium extract on 2,4-dinitrochlorobenzene-induced atopic dermatitis-like lesions in BALB/c mice

PubMed Central

Han, Hyoung-Min; Kim, Seung-Ju; Kim, Jong-Sik; Kim, Bum Hoi; Lee, Hai Woong; Lee, Yong Tae; Kang, Kyung-Hwa

2016-01-01

Artemisia argyi Folium has been used to treat skin diseases, including eczema and dermatitis, in South Korean medicine. The present study investigated the curative effects of Artemisia argyi Folium extract (AAFE) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in a BALB/c mouse model. Briefly, the dorsal skin of the BALB/c mice was sensitized three times with DNCB, whereas the ears were challenged twice. Repeated treatment with DNCB induced AD-like lesions. The effects of AAFE on AD-like lesions were evaluated by clinical observation, histopathological analysis, immunohistochemistry and enzyme-linked immunosorbent assay. In addition, reverse transcription-polymerase chain reaction and western blotting were performed. Treatment with AAFE reduced AD-like lesions, as determined by clinical observation, histopathological analysis, and detection of the serum levels of histamine, immunoglobulin E and cytokines. With regards to its mechanism of action, AAFE inhibited the phosphorylation of Lck/yes-related novel tyrosine kinase (Lyn), spleen tyrosine kinase (Syk), mitogen-activated protein kinases (MAPKs), phosphoinositide 3-kinase (PI3K)/Akt and IκBα, which have essential roles in the production of various cytokines in lymph nodes. The suppressive activity of AAFE may be due to the inhibition of a series of immunopathological events, including the release of proinflammatory cytokines. The results of the present study strongly suggest that AAFE exerts an anti-AD effect by inhibiting the Lyn, Syk, MAPKs, PI3K/Akt and IκBα pathways. Therefore, AAFE may be considered an effective herbal remedy for the treatment of AD. PMID:27571702

Comparisons of stuttering frequency during and after speech initiation in unaltered feedback, altered auditory feedback and choral speech conditions.

PubMed

Saltuklaroglu, Tim; Kalinowski, Joseph; Robbins, Mary; Crawcour, Stephen; Bowers, Andrew

2009-01-01

Stuttering is prone to strike during speech initiation more so than at any other point in an utterance. The use of auditory feedback (AAF) has been found to produce robust decreases in the stuttering frequency by creating an electronic rendition of choral speech (i.e., speaking in unison). However, AAF requires users to self-initiate speech before it can go into effect and, therefore, it might not be as helpful as true choral speech during speech initiation. To examine how AAF and choral speech differentially enhance fluency during speech initiation and in subsequent portions of utterances. Ten participants who stuttered read passages without altered feedback (NAF), under four AAF conditions and under a true choral speech condition. Each condition was blocked into ten 10 s trials separated by 5 s intervals so each trial required 'cold' speech initiation. In the first analysis, comparisons of stuttering frequencies were made across conditions. A second, finer grain analysis involved examining stuttering frequencies on the initial syllable, the subsequent four syllables produced and the five syllables produced immediately after the midpoint of each trial. On average, AAF reduced stuttering by approximately 68% relative to the NAF condition. Stuttering frequencies on the initial syllables were considerably higher than on the other syllables analysed (0.45 and 0.34 for NAF and AAF conditions, respectively). After the first syllable was produced, stuttering frequencies dropped precipitously and remained stable. However, this drop in stuttering frequency was significantly greater (approximately 84%) in the AAF conditions than in the NAF condition (approximately 66%) with frequencies on the last nine syllables analysed averaging 0.15 and 0.05 for NAF and AAF conditions, respectively. In the true choral speech condition, stuttering was virtually (approximately 98%) eliminated across all utterances and all syllable positions. Altered auditory feedback effectively inhibits stuttering immediately after speech has been initiated. However, unlike a true choral signal, which is exogenously initiated and offers the most complete fluency enhancement, AAF requires speech to be initiated by the user and 'fed back' before it can directly inhibit stuttering. It is suggested that AAF can be a viable clinical option for those who stutter and should often be used in combination with therapeutic techniques, particularly those that aid speech initiation. The substantially higher rate of stuttering occurring on initiation supports a hypothesis that overt stuttering events help 'release' and 'inhibit' central stuttering blocks. This perspective is examined in the context of internal models and mirror neurons.

Army Air Forces Statistical Digest, 1946. First Annual Number

DTIC Science & Technology

1947-06-01

accordance with AAF Letter 5-5 dated 28 April 1947, the Army Air Forces Statistical Digest has been designated as the official AAF statisti- cal yearbook...more detailed exposition, Since the Digest is designed primarily as a reference. manual, the re- action of users to its contents is important in the...distributed by this Headquarters (Statistical Control Division, Office of the Air Comptroller) is hereby designated as the official AAF statistical yearbook

In vivo metabolism and genotoxic effects of nitrated polycyclic aromatic hydrocarbons.

PubMed

Möller, L

1994-10-01

During incomplete combustion of organic matter, nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), are formed in a reaction that is catalyzed by a low pH. 2-Nitrofluorene (NF), a marker for nitro-PAHs, is metabolized in vivo by two different routes. After inhalation, potent mutagenic metabolites, hydroxylated nitrofluorenes (OH-NFs), are formed. The metabolites are distributed by systemic circulation. After oral administration, NF is reduced to the corresponding amine, a reaction mediated by the intestinal microflora. This metabolite is acetylated to 2-acetylaminofluorene (AAF), a potent carcinogen. Further ring-hydroxylation of AAF leads to detoxification and excretion. Induction of cytochrome P450s affects the metabolism, and more OH-NFs are formed. As a consequence, more mutagenic metabolites are found in the circulation. OH-NFs are excreted in the bile as, in terms of mutagenicity, totally harmless glucuronide conjugates. When these conjugates are excreted via the bile, intestinal beta-glucuronidase can liberate direct-acting mutagens in the intestine. Thus, inhalation of NF can lead to formation of potent mutagens in the intestine. NF is a direct-acting mutagen in bacterial assays and an initiator and promoter of the carcinogenic process, and gives rise to DNA adduct formation in laboratory animals.

Immediate effects of AAF devices on the characteristics of stuttering: a clinical analysis.

PubMed

Unger, Julia P; Glück, Christian W; Cholewa, Jürgen

2012-06-01

The present study investigated the immediate effects of altered auditory feedback (AAF) and one Inactive Condition (AAF parameters set to 0) on clinical attributes of stuttering during scripted and spontaneous speech. Two commercially available, portable AAF devices were used to create the combined delayed auditory feedback (DAF) and frequency altered feedback (FAF) effects. Thirty adults, who stutter, aged 18-68 years (M=36.5; SD=15.2), participated in this investigation. Each subject produced four sets of 5-min of oral reading, three sets of 5-min monologs as well as 10-min dialogs. These speech samples were analyzed to detect changes in descriptive features of stuttering (frequency, duration, speech/articulatory rate, core behaviors) across the various speech samples and within two SSI-4 (Riley, 2009) based severity ratings. A statistically significant difference was found in the frequency of stuttered syllables (%SS) during both Active Device conditions (p=.000) for all speech samples. The most sizable reductions in %SS occurred within scripted speech. In the analysis of stuttering type, it was found that blocks were reduced significantly (Device A: p=.017; Device B: p=.049). To evaluate the impact on severe and mild stuttering, participants were grouped into two SSI-4 based categories; mild and moderate-severe. During the Inactive Condition those participants within the moderate-severe group (p=.024) showed a statistically significant reduction in overall disfluencies. This result indicates, that active AAF parameters alone may not be the sole cause of a fluency-enhancement when using a technical speech aid. The reader will learn and be able to describe: (1) currently available scientific evidence on the use of altered auditory feedback (AAF) during scripted and spontaneous speech, (2) which characteristics of stuttering are impacted by an AAF device (frequency, duration, core behaviors, speech & articulatory rate, stuttering severity), (3) the effects of an Inactive Condition on people who stutter (PWS) falling into two severity groups, and (4) how the examined participants perceived the use of AAF devices. Copyright © 2012 Elsevier Inc. All rights reserved.

Dissecting choral speech: properties of the accompanist critical to stuttering reduction.

PubMed

Kiefte, Michael; Armson, Joy

2008-01-01

The effects of choral speech and altered auditory feedback (AAF) on stuttering frequency were compared to identify those properties of choral speech that make it a more effective condition for stuttering reduction. Seventeen adults who stutter (AWS) participated in an experiment consisting of special choral speech conditions that were manipulated to selectively eliminate specific differences between choral speech and AAF. Consistent with previous findings, results showed that both choral speech and AAF reduced stuttering compared to solo reading. Although reductions under AAF were substantial, they were less dramatic than those for choral speech. Stuttering reduction for choral speech was highly robust even when the accompanist's voice temporally lagged that of the AWS, when there was no opportunity for dynamic interplay between the AWS and accompanist, and when the accompanist was replaced by the AWS's own voice, all of which approximate specific features of AAF. Choral speech was also highly effective in reducing stuttering across changes in speech rate and for both familiar and unfamiliar passages. We concluded that differences in properties between choral speech and AAF other than those that were manipulated in this experiment must account for differences in stuttering reduction. The reader will be able to (1) describe differences in stuttering reduction associated with altered auditory feedback compared to choral speech conditions and (2) describe differences between delivery of a second voice signal as an altered rendition of the speakers own voice (altered auditory feedback) and alterations in the voice of an accompanist (choral speech).

32 CFR 842.136 - Claim payments and deposits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... more than $2500: HQ AAFES, Comptroller, Insurance Branch, P.O. Box 660202, Dallas, TX 75266-0202. (2) Claims payable for $2500 or less: AAFES Operations Center (OSC-AC), 2727 LBJ Highway, Dallas TX 75266...

Molecular and biochemical identification of alien chromosome additions in shallot (Allium cepa L. Aggregatum group) carrying extra chromosome(s) of bunching onion (A. fistulosum L.).

PubMed

Yaguchi, Shigenori; Hang, Tran Thi Minh; Tsukazaki, Hikaru; Hoa, Vu Quynh; Masuzaki, Shin-ichi; Wako, Tadayuki; Masamura, Noriya; Onodera, Shuichi; Shiomi, Norio; Yamauchi, Naoki; Shigyo, Masayoshi

2009-02-01

To develop the bunching onion (Allium fistulosum L.; genomes, FF) chromosome-specific genetic markers for identifying extra chromosomes, eight shallot (A. cepa L. Aggregatum group; genomes, AA)--A. fistulosum monosomic addition plants (AA+nF) and 62 shallot--A. fistulosum single-alien deletion plants (AAF-nF) were analyzed by 23 different chromosome-specific genetic markers of shallot. The eight monosomic addition plants consisted of one AA+2F, two AA+6F, and five AA+8F. Of the 62 single-alien deletion plants, 60 could be identified as six different single-alien deletion lines (AAF-1F, -3F, -4F, -6F, -7F, and -8F) out of the eight possible types. Several single-alien deletion lines were classified on the basis of leaf and bulb characteristics. AAF-8F had the largest number of expanded leaves of five deletion plants. AAF-7F grew most vigorously, as expressed by its long leaf blade and biggest bulb size. AAF-4F had very small bulbs. AAF-7F and AAF-8F had different bulbs from those of shallot as well as other types of single-alien deletion lines in skin and outer scale color. Regarding the sugar content of the bulb tissues, the single-alien deletion lines showed higher fructan content than shallot. Moreover, shallot could not produce fructan with degree of polymerization (DP) 12 or higher, although the single-alien deletion lines showed DP 20 or higher. The content of S-alk(en)yl-L-cysteine sulfoxide (ACSO) in the single-alien deletion lines was significantly lower than that in shallot. These results indicated that chromosomes from A. fistulosum might carry anonymous factors to increase the highly polymerized fructan production and inhibit the synthesis of ACSO in shallot bulbs. Accordingly, alien chromosomes from A. fistulosum in shallot would contribute to modify the quality of shallot bulbs.

Davison AAF, Ft. Belvoir Virginia. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1980-12-08

PERCENTAGE FREQUENCY OF WIND DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) 9 T7,28 DAVISON AAF/FT BELVOIR VA 69-70,73-8O JAJ STATION STATION NAME YEARS...I1AC PERCENTAGE FREQUENCY OF WINU * DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) ?~..... JAj -j&0 AAF/FT AELVOIR VA M_______________ SA Y STATION...7 ~ 66~i~ sV C 4i .3 ,’ :.r.’ _ON .AIIF_[ TD LVOl’ VP , 7.-’-7",7._-_ v.AY SO#TAT ON STATION NAMC iSCARS MONTH NOONS uL. S. T,) retup. WET BULB

Mineral Wells FAA, Texas. Ft. Wolters Mineral Wells/Texas. Revised Uniform Summary of Surface Weather Observations. Part A-F

DTIC Science & Technology

1972-05-18

DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) 0394,3 FT WIILTF.R’ AAF TEX/ MINERAI . WELLS 49-65,67-70 JUI) STATION STATION AM TRANS MONTM ALL WtI4THEk...DAIA PROCESSING DIVISCJN .~USAF ETAC PSYCHROMET(RICSU M R4 ’ AIR WEATHER SERYICE/MAC 03943 FT WO1LTER$ AAF TEX/ MINERAI . WELL$ 49*63#67-70 MAR____...AAF TEX/ MINERAI . WELLS 49-65b67-70 APRI STATION STATION NAME YEARS MONTH PAGE 2 0900-1100 HOURS (L. S. T.) Temp. WET BULB TEMPERATURE DEPRESSION (F

History of Allied Force Headquarters - Part Three, December 1943 - July 1944. Section 1

DTIC Science & Technology

1945-11-01

AG NATOUSA Itr, 322 /287 A»0, 22 Dec 43 (AG AAF/MTO files 322 ). AAF/MTO GO No 1, 1 Jaa 44. 87. AAF/MTO GO No 4, 15 Jan 44; No 12, 7 Mar 44; aad No 31...February 1944 between Major General FoGo Beaumont-Nesbitt, British Chief Liaison Officer MEF, and General Ranosovio s Chief of Staff Jugo slav Forces Hq...in occupied ITALY were brought under one central authorityp ACC 0 67. FAN Cable No 2805 CCS to Eisenhower p 26 Nov 43. 68. Memo MOS 322 -17 on Crg of

Dynamics and diversity of microbial community succession in traditional fermentation of Shanxi aged vinegar.

PubMed

Nie, Zhiqiang; Zheng, Yu; Du, Hongfu; Xie, Sankuan; Wang, Min

2015-05-01

The traditional fermentation of Shanxi aged vinegar (SAV), a well-known traditional Chinese vinegar, generally involves the preparation of starter daqu, starch saccharification, alcoholic fermentation (AF) and acetic acid fermentation (AAF). Dynamics and diversity of microbial community succession in daqu and other fermentation stages were investigated by denaturing gradient gel electrophoresis (DGGE). Results showed that eight bacterial genera and four fungal genera were found in daqu. However, Staphylococcus, Saccharopolyspora, Bacillus, Oceanobacillus, Enterobacter, Streptomyces, Eurotium, Monascus and Pichia in daqu were eradicated during AF. Four bacterial genera and three fungal genera were found in this stage. Weissella, Lactobacillus, Streptococcus, Saccharomyces, and Saccharomycopsis were the dominant microorganisms in the late stage of AF. During AAF, four bacterial genera and four fungal genera were found. Weissella, Streptococcus, Klebsiella, Escherichia, and Cladosporium gradually disappeared; the dominant microorganisms were Acetobacter, Lactobacillus, Saccharomycopsis, and Alternaria in the late stage of AAF. Alpha diversity metrics showed that fungal diversity in daqu was greater than that in AF and AAF. By contrast, bacterial diversity decreased from daqu to AF and increased in the first three days of AAF and then decreased. Hence, these results could help understand dynamics of microbial community succession in continuous fermentation of traditional Chinese vinegars. Copyright © 2014 Elsevier Ltd. All rights reserved.

Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase ι: Hoogsteen or Watson-Crick base pairing?†

PubMed Central

Donny-Clark, Kerry; Shapiro, Robert; Broyde, Suse

2009-01-01

Bypass across DNA lesions by specialized polymerases is essential for maintenance of genomic stability. Human DNA polymerase ι (polι) is a bypass polymerase of the Y family. Crystal structures of polι suggest that Hoogsteen base pairing is employed to bypass minor groove DNA lesions, placing them on the spacious major groove side of the enzyme. Primer extension studies have shown that polι is also capable of error-free nucleotide incorporation opposite the bulky major groove adduct N-(deoxyguanosin-8-yl)-2-acetyl-aminofluorene (dG-AAF). We present molecular dynamics simulations and free energy calculations suggesting that Watson-Crick base pairing could be employed in polι for bypass of dG-AAF. In polι with Hoogsteen paired dG-AAF the bulky AAF moiety would reside on the cramped minor groove side of the template. The Hoogsteen-capable conformation distorts the active site, disrupting interactions necessary for error-free incorporation of dC opposite the lesion. Watson-Crick pairing places the AAF rings on the spacious major groove side, similar to the position of minor groove adducts observed with Hoogsteen pairing. Watson-Crick paired structures show a well-ordered active site, with a near reaction-ready ternary complex. Thus our results suggest that polι would utilize the same spacious region for lesion bypass of both major and minor groove adducts. Therefore, purine adducts with bulk on the minor groove side would use Hoogsteen pairing, while adducts with the bulky lesion on the major groove side would utilize Watson-Crick base pairing as indicated by our MD simulations for dG-AAF. This suggests the possibility of an expanded role for polι in lesion bypass. PMID:19072536

Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing?

PubMed

Donny-Clark, Kerry; Shapiro, Robert; Broyde, Suse

2009-01-13

Bypass across DNA lesions by specialized polymerases is essential for maintenance of genomic stability. Human DNA polymerase iota (poliota) is a bypass polymerase of the Y family. Crystal structures of poliota suggest that Hoogsteen base pairing is employed to bypass minor groove DNA lesions, placing them on the spacious major groove side of the enzyme. Primer extension studies have shown that poliota is also capable of error-free nucleotide incorporation opposite the bulky major groove adduct N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF). We present molecular dynamics simulations and free energy calculations suggesting that Watson-Crick base pairing could be employed in poliota for bypass of dG-AAF. In poliota with Hoogsteen-paired dG-AAF the bulky AAF moiety would reside on the cramped minor groove side of the template. The Hoogsteen-capable conformation distorts the active site, disrupting interactions necessary for error-free incorporation of dC opposite the lesion. Watson-Crick pairing places the AAF rings on the spacious major groove side, similar to the position of minor groove adducts observed with Hoogsteen pairing. Watson-Crick-paired structures show a well-ordered active site, with a near reaction-ready ternary complex. Thus our results suggest that poliota would utilize the same spacious region for lesion bypass of both major and minor groove adducts. Therefore, purine adducts with bulk on the minor groove side would use Hoogsteen pairing, while adducts with the bulky lesion on the major groove side would utilize Watson-Crick base pairing as indicated by our MD simulations for dG-AAF. This suggests the possibility of an expanded role for poliota in lesion bypass.

Comparison of occipitocervical and atlantoaxial fusion in treatment of unstable Jefferson fractures.

PubMed

Hu, Yong; Yuan, Zhen-Shan; Kepler, Christopher K; Dong, Wei-Xin; Sun, Xiao-Yang; Zhang, Jiao

2017-01-01

Controversy exists regarding the management of unstable Jefferson fractures, with some surgeons performing reduction and immobilization of the patient in a halo vest and others performing open reduction and internal fixation. This study compares the clinical and radiological outcome parameters between posterior atlantoaxial fusion (AAF) and occipitocervical fusion (OCF) constructs in the treatment of the unstable atlas fracture. 68 consecutive patients with unstable Jefferson fractures treated by AAF or OCF between October 2004 and March 2011 were included in this retrospective evaluation from institutional databases. The authors reviewed medical records and original images. The patients were divided into two surgical groups treated with either AAF ( n = 48, F/M 30:18) and OCF ( n = 20, F/M 13:7) fusion. Blood loss, operative time, Japanese Orthopaedic Association (JOA) score, visual analog scale (VAS) score, atlanto-dens interval, lateral mass displacement, complications, and the bone fusion rates were recorded. Five patients with incomplete paralysis (7.4%) demonstrated postoperative improvement by more than 1 grade on the American Spinal Injury Association impairment scale. The JOA score of the AAF group improved from 12.5 ± 3.6 preoperatively to 15.7 ± 2.3 postoperatively, while the JOA score of the OCF group improved from 11.2 ± 3.3 preoperatively to 14.8 ± 4.2 postoperatively. The VAS score of AAF group decreased from 4.8 ± 1.5 preoperatively to 1.0 ± 0.4 postoperatively, the VAS score of the OCF group decreased from 5.4 ± 2.2 preoperatively to 1.3 ± 0.9 postoperatively. The OCF or AAF combined with short-term external immobilization can establish the upper cervical stability and prevent further spinal cord injury and nerve function damage.

Measurement Capabilities of the DOE ARM Aerial Facility

NASA Astrophysics Data System (ADS)

Schmid, B.; Tomlinson, J. M.; Hubbe, J.; Comstock, J. M.; Kluzek, C. D.; Chand, D.; Pekour, M. S.

2012-12-01

The Department of Energy Atmospheric Radiation Measurement (ARM) Program is a climate research user facility operating stationary ground sites in three important climatic regimes that provide long-term measurements of climate relevant properties. ARM also operates mobile ground- and ship-based facilities to conduct shorter field campaigns (6-12 months) to investigate understudied climate regimes around the globe. Finally, airborne observations by ARM's Aerial Facility (AAF) enhance the surface-based ARM measurements by providing high-resolution in situ measurements for process understanding, retrieval algorithm development, and model evaluation that is not possible using ground-based techniques. AAF started out in 2007 as a "virtual hangar" with no dedicated aircraft and only a small number of instruments owned by ARM. In this mode, AAF successfully carried out several missions contracting with organizations and investigators who provided their research aircraft and instrumentation. In 2009, the Battelle owned G-1 aircraft was included in the ARM facility. The G-1 is a large twin turboprop aircraft, capable of measurements up to altitudes of 7.5 km and a range of 2,800 kilometers. Furthermore the American Recovery and Reinvestment Act of 2009 provided funding for the procurement of seventeen new instruments to be used aboard the G-1 and other AAF virtual-hangar aircraft. AAF now executes missions in the virtual- and real-hangar mode producing freely available datasets for studying aerosol, cloud, and radiative processes in the atmosphere. AAF is also heavily engaged in the maturation and testing of newly developed airborne sensors to help foster the next generation of airborne instruments. In the presentation we will showcase science applications based on measurements from recent field campaigns such as CARES, CALWATER and TCAP.

Investigation of the interfacial reaction between metal and fluorine-contained polyimides

NASA Astrophysics Data System (ADS)

Yang, Ching-Yu; Chen, J. S.; Hsu, S. L. C.

2005-07-01

In this work, thin metal films (Cr and Ta) were deposited on fluorine-contained polyimides, 6FDA-BisAAF, and 6FDA-PPD. The chemical states of the metal/polyimide samples were characterized by using x-ray photoelectron spectroscopy (XPS). XPS analysis reveals that metal-C, C-O, and metal-O bondings are present in metallized 6FDA-BisAAF and 6FDA-PPD. C-F bonds are observed in bare 6FDA-BisAAF and 6FDA-PPD however, they are not seen in the metallized samples. Disappearance of the C-F bonding is attributed to the disruption of CF3 side groups from the main chains of 6FDA-BisAAF and 6FDA-PPD when the chains are exposed to the plasma during the metal deposition. Nevertheless, the disruption of CF3 side groups also creates sites for the formation of metal-C or C-O bondings, which provide a positive adhesion strength at the metal/polyimide interface, as revealed by the tape test.

The experience of agency in sequence production with altered auditory feedback.

PubMed

Couchman, Justin J; Beasley, Robertson; Pfordresher, Peter Q

2012-03-01

When speaking or producing music, people rely in part on auditory feedback - the sounds associated with the performed action. Three experiments investigated the degree to which alterations of auditory feedback (AAF) during music performances influence the experience of agency (i.e., the sense that your actions led to auditory events) and the possible link between agency and the disruptive effect of AAF on production. Participants performed short novel melodies from memory on a keyboard. Auditory feedback during performances was manipulated with respect to its pitch contents and/or its synchrony with actions. Participants rated their experience of agency after each trial. In all experiments, AAF reduced judgments of agency across conditions. Performance was most disrupted (measured by error rates and slowing) when AAF led to an ambiguous experience of agency, suggesting that there may be some causal relationship between agency and disruption. However, analyses revealed that these two effects were probably independent. A control experiment verified that performers can make veridical judgments of agency. Published by Elsevier Inc.

Exploring microbial succession and diversity during solid-state fermentation of Tianjin duliu mature vinegar.

PubMed

Nie, Zhiqiang; Zheng, Yu; Wang, Min; Han, Yue; Wang, Yuenan; Luo, Jianmei; Niu, Dandan

2013-11-01

Tianjin duliu mature vinegar was one of famous Chinese traditional vinegars. The unique flavor and taste of vinegar are mainly generated by the multitudinous microorganisms during fermentation. In this research, the composition and succession of microbial communities in the entire solid-state fermentation were investigated, including starter daqu and acetic acid fermentation (AAF). Molds and yeasts in daqu, including Aspergillus, Saccharomycopsis and Pichia, decreased in AAF. The bacterial compositions increased from four genera in daqu to more than 13 genera in AAF. Principal component analysis showed that Acetobacter, Gluconacetobacter, Lactobacillus and Nostoc were dominant bacteria that were correlated well with AAF process. In the early fermentation period, lactic acid bacteria (LAB) decreased while acetic acid bacteria and Nostoc increased rapidly with the accumulation of total acids. Then, the abundance and diversity of LAB increased (more than 80%), indicating that LAB had important influences on the flavor and taste of vinegar. Copyright © 2013 Elsevier Ltd. All rights reserved.

Flight measurement and analysis of AAFE RADSCAT wind speed signature of the ocean

NASA Technical Reports Server (NTRS)

Schroeder, L. C.; Jones, W. L.; Schaffner, P. R.; Mitchell, J. L.

1984-01-01

The advanced aerospace flight experiment radiometer scatterometer (AAFE RADSCAT) which was developed as a research tool to evaluate the use of microwave frequency remote sensors to provide wind speed information at the ocean surface is discussed. The AAFE RADSCAT helped establish the feasibility of the satellite scatterometer for measuring both wind speed and direction. The most important function of the AAFE RADSCAT was to provide a data base of ocean normalized radar cross section (NRCS) measurements as a function of surface wind vector at 13.9 GHz. The NRCS measurements over a wide parametric range of incidence angles, azimuth angles, and winds were obtained in a series of RADSCAT aircraft missions. The obtained data base was used to model the relationship between k sub u band radar signature and ocean surface wind vector. The models developed therefrom are compared with those used for inversion of the SEASAT-A satellite scatterometer (SASS) radar measurements to wind speeds.

Quantifying the global contribution of alcohol consumption to cardiomyopathy.

PubMed

Manthey, Jakob; Imtiaz, Sameer; Neufeld, Maria; Rylett, Margaret; Rehm, Jürgen

2017-05-25

The global impact of alcohol consumption on deaths due to cardiomyopathy (CM) has not been quantified to date, even though CM contains a subcategory for alcoholic CM with an effect of heavy drinking over time as the postulated underlying causal mechanism. In this feasibility study, a model to estimate the alcohol-attributable fraction (AAF) of CM deaths based on alcohol exposure measures is proposed. A two-step model was developed based on aggregate-level data from 95 countries, including the most populous (data from 2013 or last available year). First, the crude mortality rate of alcoholic CM per 1,000,000 adults was predicted using a negative binomial regression based on prevalence of alcohol use disorders (AUD) and adult alcohol per capita consumption (APC) (n = 52 countries). Second, the proportion of alcoholic CM among all CM deaths (i.e., AAF) was predicted using a fractional response probit regression with alcoholic CM crude mortality rate (from Step 1), AUD prevalence, APC per drinker, and Global Burden of Disease region as predictions. Additional models repeated these steps by sex and for the wider Global Burden of Disease study definition of CM. There were strong correlations (>0.9) between the crude mortality rate of alcoholic CM and the AAFs, supporting the modeling strategy. In the first step, the population-weighted mean crude mortality rate was estimated at 8.4 alcoholic CM deaths per 1,000,000 (95% CI: 7.4-9.3). In the second step, the global AAFs were estimated at 6.9% (95% CI: 5.4-8.4%). Sex-specific figures suggested a lower AAF among females (2.9%, 95% CI: 2.3-3.4%) as compared to males (8.9%, 95% CI: 7.0-10.7%). Larger deviations between observed and predicted AAFs were found in Eastern Europe and Central Asia. The model proposed promises to fill the gap to include AAFs for CM into comparative risk assessments in the future. These predictions likely will be underestimates because of the stigma involved in all fully alcohol-attributable conditions and subsequent problems in coding of alcoholic CM deaths.

Unusual hydrogen bonding patterns in AF (aminofluorene) and AAF (acetylaminofluorene) modified DNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broyde, S.; Hingerty, B.E.; Shapiro, R.

1989-01-01

New structures are presented for AF and AAF modified DNAs that place the carcinogen in the minor groove of a B-DNA helix. These structures employ non-Watson-Crick base pairing schemes with syn guanine at the modification site. 32 refs., 9 figs.

Flavor, relative palatability and components of cow's milk hydrolysed formulas and amino acid-based formula.

PubMed

Miraglia Del Giudice, Michele; D'Auria, Enza; Peroni, Diego; Palazzo, Samuele; Radaelli, Giovanni; Comberiati, Pasquale; Galdo, Francesca; Maiello, Nunzia; Riva, Enrica

2015-06-03

Both extensively hydrolysed formulas (eHF) and amino acid-based formula (AAFs) have been demonstrated effective for the treatment of CMA. However, in clinical practice, parents complain that hydrolysates are rejected by children due to their bad taste. Flavor of hydrolysed formulas has been poorly investigated although it affects the acceptance of milk over all the other attributes. The aim of the present study was to understand the factors underlying the unpleasant flavor of hydrolysed 25 formulas and amino acid-based formula. One hundred and fifty trained panelists performed a randomized-double-blind test with different milks. The smell, texture, taste and aftertaste of each formula were evaluated on a scale ranging from -2 (worst) to 2 (best). Formulas showed significant difference, as compared to cow's milk, in smell, texture, taste and aftertaste. Overall, whey eHFs were judged of better palatability than casein eHF and the AAFs (p < 0.05). Whey eHF showed significant differences among them for sensory attributes, especially for taste and aftertaste. These results suggest that a broad range of flavor exists among the hydrolysed formulas. Further studies, adequately designed to investigate the relationship between milks' flavor and nutrient profile of hydrolysed formulas are warranted.

Longitudinal Average Attributable Fraction as a Method for Studying Time-Varying Conditions and Treatments on Recurrent Self-rated Health: The Case of Medications in Older Adults with Multiple Chronic Conditions

PubMed Central

Allore, Heather G.; Zhan, Yilei; Tinetti, Mary; Trentalange, Mark; McAvay, Gail

2015-01-01

Purpose The objective is to modify the longitudinal extension of the average attributable fraction (LE-AAF) for recurrent outcomes with time-varying exposures and control for covariates. Methods We included Medicare Current Beneficiary Survey participants with two or more chronic conditions enrolled from 2005-2009 with follow-up through 2011. Nine time-varying medications indicated for nine time-varying common chronic conditions and 14 out of 18 forward-selected participant characteristics were used as control variables in the generalized estimating equations step of the LE-AAF to estimate associations with the recurrent universal health outcome self-rated health (SRH). Modifications of the LE-AAF were made to accommodate these indicated medication-condition interactions and covariates. Variability was empirically estimated by bias-corrected and accelerated bootstrapping. Results In the adjusted LE-AAF, thiazide, warfarin and clopidogrel had significant contributions of 1.2%, 0.4%, 0.2% respectively to low (poor or fair) SRH; while there were no significant contributions of the other medications to SRH. Hyperlipidemia significantly contributed 4.6% to high SRH. All the other conditions except atrial fibrillation contributed significantly to low SRH. Conclusions Our modifications to the LE-AAF method apply to a recurrent binary outcome with time-varying factors accounting for covariates. PMID:26033374

Dynamic microbial succession of Shanxi aged vinegar and its correlation with flavor metabolites during different stages of acetic acid fermentation.

PubMed

Zhu, Yunping; Zhang, Feifei; Zhang, Chengnan; Yang, Li; Fan, Guangsen; Xu, Youqiang; Sun, Baoguo; Li, Xiuting

2018-06-05

Shanxi aged vinegar (SAV), one of the famous Chinese vinegars, is produced by multispecies solid-state fermentation in which the acetic acid fermentation stage (AAF) is especially important. However, how bacterial succession and their metabolites change along with the different stages of AAF is still poorly understood. In this study, we investigated the dynamic bacterial succession and flavor formation in three batches of SAV using high-throughput sequencing and metabolomics approaches. It is interesting to find that AAF can be divided into three stages based on its bacterial community succession (early stage, days 0-4; medium stage, days 5-21; and later stage, days 22-26). Pantoea, Pediococcus, Lactococcus and Rhizobium played an important role in the early stage; Lactobacillus was dominant in the medium stage (67.72%); and Acetobacter, Komagataeibacter and Kroppenstedtia were the key bacteria in the later stage. A total of seven organic acids and 42 volatile constituents (esters, alcohol, ketones and aldehydes) were detected during the AAF. Spearman correlation analysis showed a significant correlation between the bacterial community and these flavor metabolites during the AAF of the SAV. This is the first report to explore the relationships between volatile flavor metabolites and bacterial community succession by a three-staged method and provide theoretical support for a flavor formation mechanism in traditional SAV.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: PAINT OVERSPRAY ARRESTOR, AAF INTERNATIONAL DRIPAK 90-95%

EPA Science Inventory

The report gives results of March 26-29, 1999, tests of AAF International's DriPak 90-95% paint overspray arrestor (POA) as part of an evaluation of POAs by EPA's Air Pollution Control Technology (APCT) Environmental Technology Verification (ETV) Program. The basic performance fa...

ENVIRONMENTAL TECHNOLOGY VERIFICATON: TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS AAF INTERNATIONAL DRIPAK 90/95%

EPA Science Inventory

The Environmental Technology Verification report discusses the technology and performance of the DriPak 90/95% air filter for dust and bioaerosol filtration manufactured by AAF International. The pressure drop across the filter was 104 Pa clean and 348 Pa dust loaded, and the fil...

ENVIRONMENTAL TECHNOLOGY VERIFICATIONTEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS AAF INTERNATIONAL BIOCEL I (TYPE SH)

EPA Science Inventory

The Environmental Technology Verification report discusses the technology and performance of the BioCel I (Type SH) air filter for dust and bioaerosol filtration manufactured by AAF International. The pressure drop across the filter was 236 Pa clean and 478 Pa dust loaded, and th...

ENVIRONMENTAL TECHNOLOGY VERIFICATION, TEST REPORT OF CONTROL OF BIOAEROSOLS IN HVAC SYSTEMS:AAF INTERNATIONAL, PERFECTPLEAT ULTRA, 175-102-863

EPA Science Inventory

The Environmental Technology Verification report discusses the technology and performance of the PerfectPleat Ultra 175-102-863 air filter for dust and bioaerosol filtration manufactured by AAF International. The pressure drop across the filter was 112 Pa clean and 229 Pa dust lo...

Randomized Clinical Trial: The Use of SpeechEasy® in Stuttering Treatment

ERIC Educational Resources Information Center

Ritto, Ana Paula; Juste, Fabiola Staróbole; Stuart, Andrew; Kalinowski, Joseph; de Andrade, Claudia Regina Furquim

2016-01-01

Background: Numerous studies have demonstrated the benefit of devices delivering altered auditory feedback (AAF) as a therapeutic alternative for those who stutter. Aims: The effectiveness of a device delivering AAF (SpeechEasy®) was compared with behavioural techniques in the treatment of stuttering in a randomized clinical trial. Methods &…

Geraniol attenuates 2-acetylaminofluorene induced oxidative stress, inflammation and apoptosis in the liver of wistar rats.

PubMed

Hasan, Syed Kazim; Sultana, Sarwat

2015-01-01

2-Acetylaminofluorene (2-AAF), is a well-known liver toxicant, generally used to induce tumors in laboratory animals. Geraniol (GE), a monoterpene found in essential oils of herbs and fruits, has been known to possess preventive efficacy against chemically induced toxicities. The present study was designed to analyze the protective effect of GE against 2-AAF induced oxidative stress, inflammation, hyperproliferation and apoptotic tissue damage in the liver of female Wistar rats. 2-AAF (0.02% w/w in diet) was administered and subjected to partial hepatectomy, as a mitogenic stimulus for the induction of hyperproliferation of liver tissue. GE was pre-treated orally at two different doses (100 and 200 mg/kg b.wt.) dissolved in corn oil. GE pre-treatment significantly ameliorated 2-AAF induced oxidative damage by diminishing tissue lipid peroxidation accompanied by the increase in enzymatic activities of catalase, glutathione peroxidase, glutathione reductase, superoxide dismutase and reduced glutathione content. The level of serum toxicity markers (AST, ALT, LDH) was found to be decreased. Pre-treatment with GE downregulated the expression of caspase-3,9, COX-2, NFkB, PCNA, iNOS, VEGF and significantly decreased disintegration of DNA. Histological findings further revealed that GE significantly restores the architecture of liver tissue. In the light of the above observations it may be concluded that GE may be used as preventive agent against 2-AAF induced oxidative stress, inflammation, hyperproliferation and apoptotic damage.

Evaluation of Efficacy and Safety of Longterm Feeding with Amino Acid-Based Formula in Infants with Cow’s Milk Protein Allergy: Results of the Open-Label Prospective Controlled Post-Registration Trial.

PubMed

Novik, G A; Khaleva, E G; Bychkova, N V; Zdanova, M V

The cow’s milk allergy (CMA) prevalence is 2−3% in children under one year. Approximately in 5% of cases transferring to extensively hydrolysed formula (eHF) doesn’t lead to disappearance of CMA symptoms. Evaluation of efficacy and safety of amino-acid formula (AAF) longterm feeding in children under one year and development of predictors of successful transfer from AAF to eHF. In open-label prospective post-registration trial duration of 365 days were included 43 children aged from 3 to 12 months with CMA. CMA was based on Russian and international guidelines. When a patient was included in the trial, child received eHF for 4 weeks with the evaluation of the effect of elimination diet (ED): in case of absence of effect, for diagnostic purposes child feed with AAF for 2 weeks and upon receiving the effect, child continued to receive it for at least 6 months. Diet was considered effective if there were observed disappearance of clinical manifestations of CMA during of formula using. Children fed with AAF gain weight and increased height statistically higher during the first 6 months, compared with children receiving eHF, but without subsequent difference in a year. After 4 weeks’ of AAF feeding, there was a significant decrease in SCORAD index from 46.84 (SD 4.164) to 2.52 (SD 2.204) (p=0.005); disappearance of gastrointestinal manifestations of CMA from 3 to 14 day. After 4 weeks, the 100% normalization of previously elevated faecal calprotectin (p<0.05) was observed; and after 6months. ED, in 60% of children normalization of the index of activation of basophils with milk was observed. 38.7% of children were transferred to eHF in 6 months, 12.9% and 25.8% in 9 and 12 months respectively. Use of AAF for children with CMA is an effective and safe treatment without lengthening the period of elimination, which is necessary for the formation of tolerance to cow’s milk protein and has a positive impact on weight and height. Normalization of specific activation of basophils with milk could be considered as a predictor of successful transfer from AAF to eHF in children with CMA.

77 FR 22475 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

..., Orig, CANCELLED Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, RADAR-1, Orig Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, RADAR-2, Orig Lake Havasu City, AZ, Lake Havasu... Opelousas, LA, St Landry Parish-Ahart Field, NDB RWY 18, Amdt 3 Opelousas, LA, St Landry Parish-Ahart Field...

78 FR 22363 - Environmental Impact Statement for the All Aboard Florida Miami-Orlando Passenger Rail Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... need and demand for safe, convenient, and reliable transportation through the development of a... objectives concerning the environment. AAF is a subsidiary of Florida East Coast Industries, Inc. (FECI... freight service. AAF is working to secure access to use the right-of- way of State Road 528 between Cocoa...

77 FR 22340 - Section 8 Housing Assistance Payments Program-Annual Adjustment Factors, Fiscal Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... of comparability. In all other cases (i.e., unless the contract rent is reduced by comparability... level will be the new rent to owner. The new rent to owner will not be reduced below the contract rent on the effective date of the HAP contract. III. When To Use Reduced AAFs (From AAF Table 2) In...

Removal of Arsenic in Drinking Water Kinetico Inc. and Alcan Chemicals Para-Flo™ PF60 Model AA08AS with Actiguard AAFS50

EPA Science Inventory

Testing of the Kinetico Inc. and Alean Chemicals Para-FloTM PF60 Model AA08AS with Actiguard AAFS50 arsenic adsorption media filter system was conducted at the Orchard Hills Mobile Home Park (MHP) Water Treatment Plant (WTP) in Carroll Township, Pennsylvania. The source water,...

Measurements of AAFE RADSCAT antenna characteristics

NASA Technical Reports Server (NTRS)

Cross, A. E.; Jones, W. L., Jr.; Jones, A. L.

1977-01-01

Antenna characteristics (active and passive) for a modified AAFE-RADSCAT parabolic dish antenna are documented for a variety of antenna configurations. The modified antenna was a replacement for the original unit which was damaged in January 1975. Pattern measurements made at Langley Research Center and Johnson Space Center are presented, with an analysis of the results. Antenna loss measurements are also presented and summarized.

78 FR 57545 - Proposed Establishment of Class D Airspace and Class E Airspace; Laguna AAF, AZ

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

... Air Field (AAF), (Yuma Proving Ground), Yuma, AZ. The establishment of an air traffic control tower... Ground Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590; telephone (202) 366-9826... Proving Ground), Yuma, AZ, excluding R-2306E and R- 2307 when in effect; and Class E airspace extending...

Analysis of Bacterial Diversity During Acetic Acid Fermentation of Tianjin Duliu Aged Vinegar by 454 Pyrosequencing.

PubMed

Peng, Qian; Yang, Yanping; Guo, Yanyun; Han, Ye

2015-08-01

The vinegar pei harbors complex bacterial communities. Prior studies revealing the bacterial diversity involved were mainly conducted by culture-dependent methods and PCR-DGGE. In this study, 454 pyrosequencing was used to investigate the bacterial communities in vinegar pei during the acetic acid fermentation (AAF) of Tianjin Duliu aged vinegar (TDAV). The results showed that there were 7 phyla and 24 families existing in the vinegar pei, with 2 phyla (Firmicutes, Protebacteria) and 4 families (Lactobacillaceae, Acetobacteracae, Enterobacteriaceae, Chloroplast) predominating. The genus-level identification revealed that 9 genera were the relatively stable, consistent components in different stages of AAF, including the most abundant genus Lactobacillus followed by Acetobacter and Serratia. Additionally, the bacterial community in the early fermentation stage was more complex than those in the later stages, indicating that the accumulation of organic acids provided an appropriate environment to filter unwanted bacteria and to accelerate the growth of required ones. This study provided basic information of bacterial patterns in vinegar pei and relevant changes during AAF of TDAV, and could be used as references in the following study on the implementation of starter culture as well as the improvement of AAF process.

Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis.

PubMed

Hilbi, H; Puro, R J; Zychlinsky, A

2000-10-01

The invasive enteropathogenic bacterium Shigella flexneri activates apoptosis in macrophages. Shigella-induced apoptosis requires caspase-1. We demonstrate here that tripeptidyl peptidase II (TPPII), a cytoplasmic, high-molecular-weight protease, participates in the apoptotic pathway triggered by Shigella. The TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) and clasto-lactacystin beta-lactone (lactacystin), an inhibitor of both TPPII and the proteasome, protected macrophages from Shigella-induced apoptosis. AAF-cmk was more potent than lactacystin and irreversibly blocked Shigella-induced apoptosis by 95% at a concentration of 1 microM. Conversely, peptide aldehyde and peptide vinylsulfone proteasome inhibitors had little effect on Shigella-mediated cytotoxicity. Both AAF-cmk and lactacystin prevented the maturation of pro-caspase-1 and its substrate pro-interleukin 1beta in Shigella-infected macrophages, indicating that TPPII is upstream of caspase-1. Neither of these compounds directly inhibited caspase-1. AAF-cmk and lactacystin did not impair macrophage phagocytosis or the ability of Shigella to escape the macrophage phagosome. TPPII was also found to be involved in apoptosis induced by ATP and the protein kinase inhibitor staurosporine. We propose that TPPII participates in apoptotic pathways.

Tripeptidyl Peptidase II Promotes Maturation of Caspase-1 in Shigella flexneri-Induced Macrophage Apoptosis

PubMed Central

Hilbi, Hubert; Puro, Robyn J.; Zychlinsky, Arturo

2000-01-01

The invasive enteropathogenic bacterium Shigella flexneri activates apoptosis in macrophages. Shigella-induced apoptosis requires caspase-1. We demonstrate here that tripeptidyl peptidase II (TPPII), a cytoplasmic, high-molecular-weight protease, participates in the apoptotic pathway triggered by Shigella. The TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) and clasto-lactacystin β-lactone (lactacystin), an inhibitor of both TPPII and the proteasome, protected macrophages from Shigella-induced apoptosis. AAF-cmk was more potent than lactacystin and irreversibly blocked Shigella-induced apoptosis by 95% at a concentration of 1 μM. Conversely, peptide aldehyde and peptide vinylsulfone proteasome inhibitors had little effect on Shigella-mediated cytotoxicity. Both AAF-cmk and lactacystin prevented the maturation of pro-caspase-1 and its substrate pro-interleukin 1β in Shigella-infected macrophages, indicating that TPPII is upstream of caspase-1. Neither of these compounds directly inhibited caspase-1. AAF-cmk and lactacystin did not impair macrophage phagocytosis or the ability of Shigella to escape the macrophage phagosome. TPPII was also found to be involved in apoptosis induced by ATP and the protein kinase inhibitor staurosporine. We propose that TPPII participates in apoptotic pathways. PMID:10992446

Environmentally Benign Aircraft Anti-icing and Deicing Fluids Based on Cost Effective, Bio-based Ingredients

DTIC Science & Technology

2012-09-01

xanthan gum, welan gum, or carraggenan gum.(13) Examples of particulate thickeners include lightly cross-linked polyacrylic acid. Both types of ...based formulation.(14) The currently used Type IV AAFs are believed to primarily use polyacrylic acid (PAA) polymer, stabilized by potassium ...Prescribed by ANSI-Std Z39-18 REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information

Effects of Perceived Racism and Sexism on Psychological Well Being and the Moderating Effects of Identity Development among African and European American College Students.

ERIC Educational Resources Information Center

Highlen, Pamela S.; Tom, David M.; Ashton, Kathleen R.; Thompson, Kenya I.

The combined and singular effects of racism and sexism on African American females (AAF), males (AAM), and European American females (EAF) are examined with identity development as a moderator of psychological well being. Samples of AAF, AAM, EAF and a control group of European American Males (EAM) completed counterbalanced instruments that…

77 FR 37801 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... 17, Amdt 6 Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, ILS OR LOC RWY 26, Amdt 4 Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, VOR RWY 26, Amdt 5 Willcox, AZ, Cochise... 35, Amdt 1 La Grange, TX, Fayette Rgnl Air Center, RNAV (GPS) RWY 16, Amdt 2 La Grange, TX, Fayette...

Comparisons of Stuttering Frequency during and after Speech Initiation in Unaltered Feedback, Altered Auditory Feedback and Choral Speech Conditions

ERIC Educational Resources Information Center

Saltuklaroglu, Tim; Kalinowski, Joseph; Robbins, Mary; Crawcour, Stephen; Bowers, Andrew

2009-01-01

Background: Stuttering is prone to strike during speech initiation more so than at any other point in an utterance. The use of auditory feedback (AAF) has been found to produce robust decreases in the stuttering frequency by creating an electronic rendition of choral speech (i.e., speaking in unison). However, AAF requires users to self-initiate…

The existence of fertile hybrids of closely related model earthworm species, Eisenia andrei and E. fetida.

PubMed

Plytycz, Barbara; Bigaj, Janusz; Osikowski, Artur; Hofman, Sebastian; Falniowski, Andrzej; Panz, Tomasz; Grzmil, Pawel; Vandenbulcke, Franck

2018-01-01

Lumbricid earthworms Eisenia andrei (Ea) and E. fetida (Ef) are simultaneous hermaphrodites with reciprocal insemination capable of self-fertilization while the existence of hybridization of these two species was still debatable. During the present investigation fertile hybrids of Ea and Ef were detected. Virgin specimens of Ea and Ef were laboratory crossed (Ea+Ef) and their progeny was doubly identified. 1 -identified by species-specific maternally derived haploid mitochondrial DNA sequences of the COI gene being either 'a' for worms hatched from Ea ova or 'f' for worms hatched from Ef ova. 2 -identified by the diploid maternal/paternal nuclear DNA sequences of 28s rRNA gene being either 'AA' for Ea, 'FF' for Ef, or AF/FA for their hybrids derived either from the 'aA' or 'fF' ova, respectively. Among offspring of Ea+Ef pairs in F1 generation there were mainly aAA and fFF earthworms resulted from the facilitated self-fertilization and some aAF hybrids from aA ova but none fFA hybrids from fF ova. In F2 generation resulting from aAF hybrids mated with aAA a new generations of aAA and aAF hybrids were noticed, while aAF hybrids mated with fFF gave fFF and both aAF and fFA hybrids. Hybrids intercrossed together produced plenty of cocoons but no hatchlings independently whether aAF+aAF or aAF+fFA were mated. These results indicated that Ea and Ef species, easy to maintain in laboratory and commonly used as convenient models in biomedicine and ecotoxicology, may also serve in studies on molecular basis of interspecific barriers and mechanisms of introgression and speciation. Hypothetically, their asymmetrical hybridization can be modified by some external factors.

Synthesis, characterization and antimicrobial studies of new bispyrazolines linked via 3-aryl ring with aliphatic chains

NASA Astrophysics Data System (ADS)

Yusuf, Mohamad; Jain, Payal

2012-10-01

The bispyrazolines 4a(a'-f') and 4b(a'-f') built around the aliphatic chains of varying lengths have been prepared by refluxing bischalcones 3a(a'-f') and 3b(a'-f') with phenyl hydrazine in alcoholic medium. The reactions of chalcones 2a and 2b with suitable 1,ω-dibromoalkanes in the presence of anhydrous K2CO3/dry acetone and Bu4N+I- (PTC) provided 3a(a'-f') and 3b(a'-f'), respectively. The antibacterial and antifungal activities of the synthesized compounds were evaluated against five bacterial and four fungal strains. The compounds 3ba', 3bc', 3bd', 3be', 3af', 4aa' and 4ba' showed better MIC (μg/mL) against the tested microorganisms.

Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala-Phe-chloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells.

PubMed

Bury, M; Młynarczuk, I; Pleban, E; Hoser, G; Kawiak, J; Wójcik, C

2001-01-01

AAF-AMC is not a specific TPP II substrate, since it is also hydrolyzed by purified proteasomes. Moreover, AAF-cmk, claimed to be a specific TPP II inhibitor, also inhibits the chymotrypsin-like activity of the proteasome. While AAF-cmk itself is mildly cytostatic to U-937 cells and induces cell cycle block in G1, its combination with PSI does not induce an increase in the cytostatic/cytotoxic effects. This suggests that TPP II is possibly less important for cell metabolism than it was previously believed and it is less probable that it can be able to fully compensate for the loss of the proteasome function.

Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase.

PubMed

Ezaki, J; Takeda-Ezaki, M; Kominami, E

2000-09-01

The specific accumulation of a hydrophobic protein, subunit c of ATP synthase, in lysosomes from the cells of patients with the late infantile form of NCL (LINCL) is caused by a defect in the CLN2 gene product, tripeptidyl peptidase I (TPP-I). The data here show that TPP-I is involved in the initial degradation of subunit c in lysosomes and suggest that its absence leads directly to the lysosomal accumulation of subunit c. The inclusion of a specific inhibitor of TPP-I, Ala-Ala-Phe-chloromethylketone (AAF-CMK), in the culture medium of normal fibroblasts induced the lysosomal accumulation of subunit c. In an in vitro incubation experiment the addition of AAF-CMK to mitochondrial-lysosomal fractions from normal cells inhibited the proteolysis of subunit c, but not the b-subunit of ATP synthase. The use of two antibodies that recognize the aminoterminal and the middle portion of subunit c revealed that the subunit underwent aminoterminal proteolysis, when TPP-I, purified from rat spleen, was added to the mitochondrial fractions. The addition of both purified TPP-I and the soluble lysosomal fractions, which contain various proteinases, to the mitochondrial fractions resulted in rapid degradation of the entire molecule of subunit c, whereas the degradation of subunit c was markedly delayed through the specific inhibition of TPP-I in lysosomal extracts by AAF-CMK. The stable subunit c in the mitochondrial-lysosomal fractions from cells of a patient with LINCL was degraded on incubation with purified TPP-I. The presence of TPP-I led to the sequential cleavage of tripeptides from the N-terminus of the peptide corresponding to the amino terminal sequence of subunit c.

Mutagenic, cytotoxic, and teratogenic effects of 2-acetylaminofluorene and reactive metabolites in vitro.

PubMed

Faustman-Watts, E M; Yang, H Y; Namkung, M J; Greenaway, J C; Fantel, A G; Juchau, M R

1984-01-01

The embryotoxic, mutagenic, and cytotoxic properties of 2-acetylaminofluorene (AAF) and two of its reactive metabolites, N-acetoxy-2-acetylaminofluorene (AAAF) and 2-nitrosofluorene (NF) were assessed in vitro. A combined embryo culture/biotransformation system was used to determine the ability of these compounds to produce embryonic malformations, growth retardation, and/or embryolethality. Salmonella typhimurium auxotrophs (his-) were utilized to measure the mutagenic and cytotoxic potentials of these compounds. The parent compound, AAF, did not produce embryonic malformations or mutagenicity in the absence of an added cytochrome P-450-dependent monooxygenase system. Both metabolites produced each of the measured toxic effects without supplementation of a bioactivation system. However, the three chemicals each elicited a different spectrum of malformations. Bioactivated AAF produced neural tube abnormalities, whereas embryos treated with AAAF primarily exhibited prosencephalic malformations, and NF produced abnormalities of axial rotation or flexure. NF was approximately ten times more potent than AAAF as a direct-acting mutagen but only slightly more active in producing embryonic malformations in vitro. The results indicated that differential effects on the various measured parameters could be produced by these chemicals. The results indicated further that neither NF nor AAAF appeared to be individually responsible for the neural tube abnormalities generated by biotransformed AAF.

Index to Army Times 1991

DTIC Science & Technology

1992-08-01

AIRCRAFT) Winging it. Army Times; Oct. 14, 1991; 52(11): p. 26. AAC SEE ARMY ACQUISITION CORPS (AAC) AAFES SEE ARMY AND AIR FORCE EXCHANGE SERVICE (AAFES...allies in Germany. Army Times; Sept. 23, 1991; 52(8): p. 10. GLOBAL POSITIONING SYSTEM (GPS) SEE OPERATION DESERT STORK , 1991--GLOSAL POSITIONING SYSTEM (G...COMPETITIONS Golden Knights triumph. Army Times; Oct. 28, 1991; 52(13): p. 14. GOVERNMENT ACCOUNTING OFFICE (GAO)--AUOIT--HELICOPTERS Republicans move to clip

Army Family Policies and Practices: A Summary of Regulations, Letters, Pamphlets, and Circulars That Impact on Army Families

DTIC Science & Technology

1990-05-01

AR 60-10 Army and Air Force Exchange Service (AAFES) General Policies.. ................. . . . 12 AR 60-2 0 Army and Air Force Exchange Service (AAFES...Initial Active Duty, Initial Active Duty for Training, and Reserve Forces Duty . . . . . . ........... 29 AR 601-27 Military Entrance Processing...AR 608-20 Voting by Personnel of the Armed Forces . . . . .... 35 AR 608-25 Retirement Services Program . ...... 36 AR 608-61 Application for

Hepatoprotective Potential of Some Local Medicinal Plants against 2-Acetylaminoflourene-Induced Damage in Rat.

PubMed

Adetutu, Adewale; Olorunnisola, Olubukola S

2013-01-01

The in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of Bridelia ferruginea, Vernonia amygdalina, Tridax procumbens, Ocimum gratissimum, and Lawsonia inermis in Wistar albino rats. Extracts of doses of 100 mg/kg body weight were given to rats in five groups for seven consecutive days followed by a single dose of 2-AAF (0.5 mmol/kg body weight). The rats were sacrificed after 24 hours and their bone marrow smears were prepared on glass slides stained with Giemsa. The micronucleated polychromatic erythrocyte cells (mPCEs) were thereafter recorded. The hepatoprotective effects of the plant extracts against 2-AAF-induced liver toxicity in rats were evaluated by monitoring the levels of alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and histopathological analysis. The results of the 2-AAF-induced liver toxicity experiments showed that rats treated with the plant extracts (100 mg/kg) showed a significant decrease in mPCEs as compared with the positive control. The rats treated with the plant extracts did not show any significant change in the concentration of ALP and GGT in comparison with the negative control group whereas the 2-AAF group showed a significant increase (P < 0.05) in these parameters. Some of the leaf extracts also showed protective effects against histopathological alterations. This study suggests that the leaf extracts have hepatoprotective potential, thereby justifying their ethnopharmacological uses.

The existence of fertile hybrids of closely related model earthworm species, Eisenia andrei and E. fetida

PubMed Central

Bigaj, Janusz; Osikowski, Artur; Hofman, Sebastian; Falniowski, Andrzej; Panz, Tomasz; Grzmil, Pawel; Vandenbulcke, Franck

2018-01-01

Lumbricid earthworms Eisenia andrei (Ea) and E. fetida (Ef) are simultaneous hermaphrodites with reciprocal insemination capable of self-fertilization while the existence of hybridization of these two species was still debatable. During the present investigation fertile hybrids of Ea and Ef were detected. Virgin specimens of Ea and Ef were laboratory crossed (Ea+Ef) and their progeny was doubly identified. 1 –identified by species-specific maternally derived haploid mitochondrial DNA sequences of the COI gene being either ‘a’ for worms hatched from Ea ova or ‘f’ for worms hatched from Ef ova. 2 –identified by the diploid maternal/paternal nuclear DNA sequences of 28s rRNA gene being either ‘AA’ for Ea, ‘FF’ for Ef, or AF/FA for their hybrids derived either from the ‘aA’ or ‘fF’ ova, respectively. Among offspring of Ea+Ef pairs in F1 generation there were mainly aAA and fFF earthworms resulted from the facilitated self-fertilization and some aAF hybrids from aA ova but none fFA hybrids from fF ova. In F2 generation resulting from aAF hybrids mated with aAA a new generations of aAA and aAF hybrids were noticed, while aAF hybrids mated with fFF gave fFF and both aAF and fFA hybrids. Hybrids intercrossed together produced plenty of cocoons but no hatchlings independently whether aAF+aAF or aAF+fFA were mated. These results indicated that Ea and Ef species, easy to maintain in laboratory and commonly used as convenient models in biomedicine and ecotoxicology, may also serve in studies on molecular basis of interspecific barriers and mechanisms of introgression and speciation. Hypothetically, their asymmetrical hybridization can be modified by some external factors. PMID:29370238

Does the Arctic Amplification peak this decade?

NASA Astrophysics Data System (ADS)

Martin, Torge; Haine, Thomas W. N.

2017-04-01

Temperatures rise faster in the Arctic than on global average, a phenomenon known as Arctic Amplification. While this is well established from observations and model simulations, projections of future climate (here: RCP8.5) with models of the Coupled Model Intercomparison Project phase 5 (CMIP5) also indicate that the Arctic Amplification has a maximum. We show this by means of an Arctic Amplification factor (AAF), which we define as the ratio of Arctic mean to global mean surface air temperature (SAT) anomalies. The SAT anomalies are referenced to the period 1960-1980 and smoothed by a 30-year running mean. For October, the multi-model ensemble-mean AAF reaches a maximum in 2017. The maximum moves however to later years as Arctic winter progresses: for the autumn mean SAT (September to November) the maximum AAF is found in 2028 and for winter (December to February) in 2060. Arctic Amplification is driven, amongst others, by the ice-albedo feedback (IAF) as part of the more general surface albedo feedback (involving clouds, snow cover, vegetation changes) and temperature effects (Planck and lapse-rate feedbacks). We note that sea ice retreat and the associated warming of the summer Arctic Ocean are not only an integral part of the IAF but are also involved in the other drivers. In the CMIP5 simulations, the timing of the AAF maximum coincides with the period of fastest ice retreat for the respective month. Presence of at least some sea ice is crucial for the IAF to be effective because of the contrast in surface albedo between ice and open water and the need to turn ocean warming into ice melt. Once large areas of the Arctic Ocean are ice-free, the IAF should be less effective. We thus hypothesize that the ice retreat significantly affects AAF variability and forces a decline of its magnitude after at least half of the Arctic Ocean is ice-free and the ice cover becomes basically seasonal.

Effect of single DNA lesions on in vitro replication with DNA polymerase III holoenzyme. Comparison with other polymerases.

PubMed

Belguise-Valladier, P; Maki, H; Sekiguchi, M; Fuchs, R P

1994-02-11

In the present work, we have studied in vitro replication of N-2-acetylaminofluorene (AAF) or cis-diamminedichloroplatinum II (cis-DDP) single modified DNA templates. We used the holoenzyme (pol III HE) or the alpha subunit of DNA polymerase III, which is involved in SOS mutagenesis, and other DNA polymerases in order to compare enzymes having different biological roles and properties. Single-stranded oligonucleotides (63-mer) bearing a single AAF adduct at one of the different guanine residues of the NarI sequence (-G1G2CG3CC-) have been used in primer extension assays. Site-specifically platinated 5'd(ApG) or 5'd(GpG) oligonucleotides were constructed and similarly used in primer extension assays. In all cases, irrespective of both the chemical nature of the lesion (i.e. AAF or cis-DDP) and its local sequence context (i.e. the 3 different sites for AAF adducts within the NarI site) replication by pol III HE and pol I Klenow fragment (pol I Kf) stops one base prior to the adduct site. Removal of the 3'-->5' proofreading activity alone was not sufficient to trigger bypass of DNA lesions. Indeed, when proofreading activity of pol I is inactivated by a point mutation (pol I Kf (exo-)), the major replication product corresponds to the position opposite the adduct site showing that incorporation across from the AAF adduct is possible. These results suggest that a polymerase with proofreading activity is actually found to stop one nucleotide before the adduct not because it is unable to insert a nucleotide opposite the adduct but most likely because elongation past the adduct is strongly impaired, giving thus an increased time frame for the proofreading exonuclease to remove the base inserted across from the adduct. These results are discussed in terms of their implications for error-free and error-prone bypass in vivo.

AAFES Gas Station at Creech Air Force Base Environmental Assessment

DTIC Science & Technology

2009-07-01

Creech AFB with modern fuel refilling services. The AAFES Gas Station would include a one pump two hose filling station, a concrete slab, a 12,000...at both end of each hose , a shear valve at the base of the pump, and an electronic sensor in the dispenser to detect fuel leakage. In order to add...designed and built with leak prevention safety equipment. Shut- off valves would be installed at both ends of each hose . A shear valve would be

Fort Devens AAF, Massachusetts. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1977-04-07

uaay oI Surlace Weatherj .>jObservations (RUSSWO) - Fort Devens AAL’, al 6.PRFOMIG.REOTNMR t- iassachusett s 6 EFRIGO EOTNME 7. AUTNOR(o) S. CONTRACT...for Fort Devens AAP, M’assachusetts contains the following parts: (A) heather Conditions; Atmospheric e-henoinena; (B) Precipitation, Snowfall and Snow...SEUIYCLASSIFICATION OF THIS PAGE (nohn Data Entered) %- - - - - .~~ -V- 2, SECURITY CLASSIFICATION OF THIS PAGE(W4 Dat. Rnteted) 19. ** Fort Devens AAF, M’ass4

Model study of St. Stephen powerhouse fish passage facilities, Cooper River rediversion project, South Carolina. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hite, J.E.; Murphy, T.E.

1998-09-01

This report documents a model study of the St. Stephen Power Plant, located in Berkely County, South Carolina. A previous model study revealed that the fish lift at the powerhouse could be improved by providing auxiliary attraction flows to the fish entrances. An auxiliary attraction flow (AAF) system was proposed that uses a siphon to obtain the auxiliary attraction water from the reservoir. The model investigations reported herein address the flow conditions at the discharge end of the siphon; the hydraulic aspects of the siphon are not addressed. Three different models were used to evaluate flow conditions at the dischargemore » end of the AAF system. A 1:25-scale model of the St. Stephen powerhouse was used to improve the fish entrance conditions and to evaluate the outlet conditions for the initial AAF system. As the investigations progressed, the design of the siphon discharge system was modified to include downstream fish migration and debris passage.« less

Hepatoprotective Potential of Some Local Medicinal Plants against 2-Acetylaminoflourene-Induced Damage in Rat

PubMed Central

Adetutu, Adewale; Olorunnisola, Olubukola S.

2013-01-01

The in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of Bridelia ferruginea, Vernonia amygdalina, Tridax procumbens, Ocimum gratissimum, and Lawsonia inermis in Wistar albino rats. Extracts of doses of 100 mg/kg body weight were given to rats in five groups for seven consecutive days followed by a single dose of 2-AAF (0.5 mmol/kg body weight). The rats were sacrificed after 24 hours and their bone marrow smears were prepared on glass slides stained with Giemsa. The micronucleated polychromatic erythrocyte cells (mPCEs) were thereafter recorded. The hepatoprotective effects of the plant extracts against 2-AAF-induced liver toxicity in rats were evaluated by monitoring the levels of alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and histopathological analysis. The results of the 2-AAF-induced liver toxicity experiments showed that rats treated with the plant extracts (100 mg/kg) showed a significant decrease in mPCEs as compared with the positive control. The rats treated with the plant extracts did not show any significant change in the concentration of ALP and GGT in comparison with the negative control group whereas the 2-AAF group showed a significant increase (P < 0.05) in these parameters. Some of the leaf extracts also showed protective effects against histopathological alterations. This study suggests that the leaf extracts have hepatoprotective potential, thereby justifying their ethnopharmacological uses. PMID:24163694

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

PubMed

T'jollyn, Huybrecht; Snoeys, Jan; Van Bocxlaer, Jan; De Bock, Lies; Annaert, Pieter; Van Peer, Achiel; Allegaert, Karel; Mannens, Geert; Vermeulen, An; Boussery, Koen

2017-06-01

Although the measurement of cytochrome P450 (CYP) contributions in metabolism assays is straightforward, determination of actual in vivo contributions might be challenging. How representative are in vitro for in vivo CYP contributions? This article proposes an improved strategy for the determination of in vivo CYP enzyme-specific metabolic contributions, based on in vitro data, using an in vitro-in vivo extrapolation (IVIVE) approach. Approaches are exemplified using tramadol as model compound, and CYP2D6 and CYP3A4 as involved enzymes. Metabolism data for tramadol and for the probe substrates midazolam (CYP3A4) and dextromethorphan (CYP2D6) were gathered in human liver microsomes (HLM) and recombinant human enzyme systems (rhCYP). From these probe substrates, an activity-adjustment factor (AAF) was calculated per CYP enzyme, for the determination of correct hepatic clearance contributions. As a reference, tramadol CYP contributions were scaled-back from in vivo data (retrograde approach) and were compared with the ones derived in vitro. In this view, the AAF is an enzyme-specific factor, calculated from reference probe activity measurements in vitro and in vivo, that allows appropriate scaling of a test drug's in vitro activity to the 'healthy volunteer' population level. Calculation of an AAF, thus accounts for any 'experimental' or 'batch-specific' activity difference between in vitro HLM and in vivo derived activity. In this specific HLM batch, for CYP3A4 and CYP2D6, an AAF of 0.91 and 1.97 was calculated, respectively. This implies that, in this batch, the in vitro CYP3A4 activity is 1.10-fold higher and the CYP2D6 activity 1.97-fold lower, compared to in vivo derived CYP activities. This study shows that, in cases where the HLM pool does not represent the typical mean population CYP activities, AAF correction of in vitro metabolism data, optimizes CYP contributions in the prediction of hepatic clearance. Therefore, in vitro parameters for any test compound, obtained in a particular batch, should be corrected with the AAF for the respective enzymes. In the current study, especially the CYP2D6 contribution was found, to better reflect the average in vivo situation. It is recommended that this novel approach is further evaluated using a broader range of compounds.

78 FR 63860 - Amendment of Class D Airspace; Kwajalein Island, Marshall Islands, RMI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

...This action amends the Kwajalein Island Class D airspace description by amending the geographic coordinates for Bucholz Army Airfield (AAF), Kwajalein Island, Marshall Islands, RMI. The Bucholz AAF geographic coordinates information was updated in the Kwajalein Island Class E airspace descriptions in 2011, but was inadvertently overlooked in the Kwajalein Island Class D airspace description. This action ensures the safety of aircraft operating in the Kwajalein Island airspace area. This is an administrative action and does not affect the operating requirements of the airspace.

Stream Channel Stability. Appendix J. Numerical Model for Routing Graded Sediments in Alluvial Channels,

DTIC Science & Technology

1981-04-01

expressed as volume of dry sediment per unit length of channel. RHB Hydraulic radius. ft SCAP(IF) Potential transport capacity of ft 3/ft material...GO) TO iSO I6=0 DO 104 IC=i,INL IA=IC+ICST-IS IF(KI(I)EQOORI(ICI).E.Q(IC2))GO TO 105 L PROPAGATION OF SHOCK WAVE AA=(QI(IC,i)/KIN)**BET AAF=AA+QL*DTS...KSI(IC).GT.0) GO Tn £09 IF(IA.EQ.i) GO TO 140 IF(XC(IA).L.E.XC(IA-i)) GO TO 11.0 C NO SHOCK IS FORMED 140 KSC(IA)=0 CO TO 104 C SHOCK IS FORMED 110

Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter.

PubMed

Steinwender, Clemens; Hönig, Simon; Kypta, Alexander; Kammler, Jürgen; Schmitt, Barbara; Leisch, Franz; Hofmann, Robert

2010-06-11

Ibutilide is a class III antiarrhythmic drug, frequently used for conversion of atrial fibrillation and flutter. Retrospective cohort evaluations found that intravenous application of magnesium enhances the efficacy of ibutilide for chemical conversion of these arrhythmias. This prospective study sought to investigate the effects of intravenously pre-injected magnesium on the conversion rate of ibutilide for typical and atypical atrial flutter. We performed a prospective, randomized, placebo-controlled study. Patients with typical atrial flutter (TAF) or atypical atrial flutter (AAF) were randomized to receive either 4 g of intravenous magnesium sulfate or placebo immediately before administration of a maximum dose of 2 mg of ibutilide fumarate. Continuous rhythm monitoring for 4 h provided information on conversion to sinus rhythm. QT interval durations were measured before randomization, after magnesium, as well as 30 min and 4 h after starting ibutilide infusion. We randomized 117 patients (58 with and 59 without pre-injection of magnesium; 65 with TAF and 52 with AAF). In patients with TAF, pre-injection of magnesium significantly improved the efficacy of ibutilide for conversion (85% with magnesium vs. 59% with placebo, p=0.017). In patients with AAF, no significant difference in conversion rates between patients receiving magnesium or placebo was detected (48% vs. 56%, p=0.189). Pre-injection of magnesium did not significantly influence the QT intervals at any time after administration of ibutilide. Pre-injection of magnesium significantly enhances the efficacy of ibutilide for the conversion of TAF but not of AAF. Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.

Randomized clinical trial: the use of SpeechEasy® in stuttering treatment.

PubMed

Ritto, Ana Paula; Juste, Fabiola Staróbole; Stuart, Andrew; Kalinowski, Joseph; de Andrade, Claudia Regina Furquim

2016-11-01

Numerous studies have demonstrated the benefit of devices delivering altered auditory feedback (AAF) as a therapeutic alternative for those who stutter. The effectiveness of a device delivering AAF (SpeechEasy®) was compared with behavioural techniques in the treatment of stuttering in a randomized clinical trial. Two groups of adults who stutter participated: group 1 consisted of 10 men and one woman aged 21-42 years (mean = 30.0). Group 2 consisted of six men and one woman aged 20-50 years (mean = 35.6). Participants in group 1 were fit with a SpeechEasy® device and were not given any additional training (i.e., supplementary fluency enhancing techniques). Participants used the device daily for 6 months. Participants in group 2 received treatment in the form of a 12-week fluency promotion protocol with techniques based on both fluency shaping and stuttering modification. There were no statistically significant differences (p > .05) between groups in participants' stuttered syllables following treatment. That is, both therapeutic protocols achieved approximately 40% reduction in number of stuttered syllables from baseline measures, with no significant relapse after 3 or 6 months post-treatment. The results suggest that the SpeechEasy® device can be a viable option for the treatment of stuttering. © 2016 Royal College of Speech and Language Therapists.

Effects of altered auditory feedback across effector systems: production of melodies by keyboard and singing.

PubMed

Pfordresher, Peter Q; Mantell, James T

2012-01-01

We report an experiment that tested whether effects of altered auditory feedback (AAF) during piano performance differ from its effects during singing. These effector systems differ with respect to the mapping between motor gestures and pitch content of auditory feedback. Whereas this action-effect mapping is highly reliable during phonation in any vocal motor task (singing or speaking), mapping between finger movements and pitch occurs only in limited situations, such as piano playing. Effects of AAF in both tasks replicated results previously found for keyboard performance (Pfordresher, 2003), in that asynchronous (delayed) feedback slowed timing whereas alterations to feedback pitch increased error rates, and the effect of asynchronous feedback was similar in magnitude across tasks. However, manipulations of feedback pitch had larger effects on singing than on keyboard production, suggesting effector-specific differences in sensitivity to action-effect mapping with respect to feedback content. These results support the view that disruption from AAF is based on abstract, effector independent, response-effect associations but that the strength of associations differs across effector systems. Copyright © 2011. Published by Elsevier B.V.

Deployment of ARM Aerial Facility Scanning Mobility Particle Sizer Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jian

2016-09-01

Atmospheric aerosols influence global climate by scattering and absorbing sunlight (direct effects) and by changing the microphysical structure, lifetime, and coverage of clouds (indirect effects). While it is widely accepted that aerosol indirect effects cool the Earth-atmosphere system by increasing cloud reflectivity and coverage, the magnitudes of the indirect effects are poorly quantified. One key aerosol property for understanding aerosol indirect effects is the ability of aerosol particles to form cloud droplets at atmospheric relevant supersaturations—i.e., cloud condensation Nuclei (CCN) activity. For particles consisting of typical atmospheric inorganic compounds, their CCN activity is well understood and can be effectively predictedmore » using Köhler theory based on physicochemical properties of the solute, such as its mass, molar volume, and activity coefficient. However, atmospheric aerosols often consist of hundreds of organic species, which can contribute ~20-90% to the total fine aerosol mass. Depending on their properties, organic species can significantly influence the ability of aerosol particles to act as CCN and form cloud droplets. This project focuses on the CCN activity of secondary organic aerosol (SOA) compounds formed from key biogenic volatile organic compounds (VOCs) under representative conditions, and the relationship between the hygroscopicity and composition of organic aerosols. The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility Aerial Facility (AAF) scanning mobility particles sizer (SMPS) was deployed during a ~ 2-week intensive measurement campaign, taking place February 10-February 23, 2016 at the Pacific Northwest National Laboratory (PNNL) Environmental Simulation Chamber. The SMPS was operated with a CCN counter (CCNc). Aerosol particles were first classified by the differential mobility analyzer inside the SMPS; the classified aerosol will then be simultaneously characterized by a condensation particle counter (CPC) (part of the SMPS) and the CCNc.« less

Fort Huachuca, Libby AAF, Arizona. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-04-22

pbenomena An the Wather Conditions kMry ebove also onply for the categories heeded -% OF UN V=? PM10 and -% OF ONS W=! OWS 20 TMIW shov the pereatage of...OF WIND V DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) 27 FT HuJil4IrA/l ifaY ALF A7 MAR-7f STATION SamIO Name vEas MONT* ALL WATHER ~fnnn-nflf...U. GLOAL CLIMATOLOGY SRANCH USAFETAC PSYCHROMETRIC SUMMARY j,~ AIR wATHER SERVICE/MAC 72273C FT ,UACHUCAILIBBY AAF AZ 61-?0 WA0

A High Resolution Radar Altimeter to Measure the Topography of Ice Sheets

NASA Technical Reports Server (NTRS)

Pawul, Rudolf A.

1997-01-01

This thesis is a reference for the Advanced Application Flight Experiment (AAFE) altimeter. The transmitter and receiver subsections are described and measurements of their current state is provided. During the 1994 NASA Greenland Experiment, the altimeter experienced several hardware malfunctions. The process of returning the radar to its fully operational state is presented in detail and necessary design modifications are explained. An updated radar user's manual is included along with various circuit designs which need to be implemented. The thesis is intended to provide an incoming graduate student with a solid foundation of the fundamentals of AAFE altimeter operation.

Operation of a Radar Altimeter over the Greenland Ice Sheet

NASA Technical Reports Server (NTRS)

Grund, Matthew D.

1996-01-01

This thesis presents documentation for the Advanced Application Flight Experiment (AAFE) pulse compression radar altimeter and its role in the NASA Multisensor Airborne Altimetry Experiment over Greenland in 1993. The AAFE Altimeter is a Ku-band microwave radar which has demonstrated 14 centimeter range precision in operation over arctic ice. Recent repairs and improvements were required to make the Greenland missions possible. Transmitter, receiver and software modifications, as well as the integration of a GPS receiver are thoroughly documented. Procedures for installation, and operation of the radar are described. Finally, suggestions are made for further system improvements.

FT Stewart AAF, Savannah, Georgia. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1979-04-18

OBSERVATIONS) 03871i FT STEWART AAF GA 67-70,73-77 SEP STATION STATION MAN, TSARS NONIN ( ~AL.L WI3ATHF:R ___ 1200-1400 CLAS NOUN$ (L.S.T.) SPEED MEAN (ENTS...0i 88:2 92.0 93.0 94t1 94.5 94.6 94.9 94.9 95.0 95.0 95.0 95.0 9590 9.0 95.0 e - , 73:1 88.31 92.5 93.4 95o 95.3 9s.6 95.8 95.8 96.1 96.1 96,1 96.1

Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model.

PubMed

Lin, M; Sun, P; Zhang, G; Xu, X; Liu, G; Miao, H; Yang, Y; Xu, H; Zhang, L; Wu, P; Li, M

2014-03-01

Normal liver has a great potential of regenerative capacity after partial hepatectomy. In clinic, however, most patients receiving partial hepatectomy are usually suffering from chronic liver diseases with severely damaged hepatocyte population. Under these conditions, activation of hepatic progenitor cell (oval cell in rodents) population might be considered as an alternative mean to enhance liver functional recovery. Vitamin K2 has been shown to promote liver functional recovery in patients with liver cirrhosis. In this study, we explored the possibility of vitamin K2 treatment in activating hepatic oval cell for liver regeneration with the classic 2-acetamido-fluorene/partial hepatectomy (2-AAF/PH) model in Sprague-Dawley rats. In 2-AAF/PH animals, vitamin K2 treatment induced a dose-dependent increase of liver regeneration as assessed by the weight ratio of remnant liver versus whole body and by measuring serum albumin level. In parallel, a drastic expansion of oval cell population as assessed by anti-OV6 and anti-CK19 immunostaining was noticed in the periportal zone of the remnant liver. Since matrilin-2 was linked to oval cell proliferation and liver regeneration after partial hepatectomy, we assessed its expression at both the mRNA and protein levels. The results revealed a significant increase after vitamin K2 treatment in parallel with the expansion of oval cell population. Consistently, knocking down matrilin-2 expression in vivo largely reduced vitamin K2-induced liver regeneration and oval cell proliferation in 2-AAF/PH animals. In conclusion, these data suggest that vitamin K2 treatment enhances liver regeneration after partial hepatectomy, which is associated with oval cell expansion and matrilin-2 up-regulation.

Surveillance of US Death Rates from Chronic Diseases Related to Excessive Alcohol Use.

PubMed

Polednak, Anthony P

2016-01-01

To assess the utility of multiple-cause (MC) death records for surveillance of US mortality rates from chronic causes related to excessive alcohol use. The Alcohol-Related Disease Impact (ARDI) resource produced estimates of the population 'alcohol attributable fraction' (AAF) due to excessive drinking for each alcohol-related (AAF > 0%) cause of death, and used AAFs to estimate numbers of alcohol-related deaths from alcohol-related underlying causes (UC) in adults age 20-64 and 65+ years in 2006-2010. For surveillance, this study used MC death file to identify individual deaths (2006-2010) with an 'alcohol-induced' cause (AAF = 100%) anywhere on the certificate, and to obtain US rates of premature death (ages 15-64 and 65-74 years) for 1999-2012. Using the selected MC records, numbers of deaths from alcohol-related chronic UC (2006-2010) were 81% of ARDI estimates for age 20-64, but only 40% for 65+ years. The MC records identified substantial numbers of deaths from causes (e.g. certain infectious diseases) not included as alcohol-related in ARDI, but included in surveillance of premature death rates for chronic UC. Also, premature death rates for chronic alcohol-induced causes using only the UC (as in routine mortality statistics) were only about half the rates based on MC; all rates increased in recent years but some reached statistical significance only by using MC. Using MC records underestimated total US deaths from alcohol-related chronic causes as the UC, but enhanced surveillance of rates for premature deaths involving chronic causes that may be related to excessive alcohol use. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.

Amino Acid-based Formula in Cow's Milk Allergy: Long-term Effects on Body Growth and Protein Metabolism.

PubMed

Canani, Roberto Berni; Nocerino, Rita; Frediani, Tullio; Lucarelli, Sandra; Di Scala, Carmen; Varin, Elena; Leone, Ludovica; Muraro, Antonella; Agostoni, Carlo

2017-04-01

The long-term effects of amino acid-based formula (AAF) in the treatment of cow's milk allergy (CMA) are largely unexplored. The present study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolyzed whey formula (eHWF), and healthy controls. A 12-month multicenter randomized control trial was conducted in outpatients with CMA (age 5-12 m) randomized in 2 groups, treated with AAF (group 1) and eHWF (group 2), and compared with healthy controls (group 3) fed with follow-on (if age <12 months) or growing-up formula (if age >12 months). At enrolment (T0), after 3 (T3), 6 (T6), and 12 months (T12) a clinical evaluation was performed. At T0 and T3, in subjects with CMA serum levels of albumin, urea, total protein, retinol-binding protein, and insulin-like growth factor 1 were measured. Twenty-one subjects in group 1 (61.9% boys, age 6.5 ± 1.5 months), 19 in group 2 (57.9% boys, age 7 ± 1.7 months) and 25 subjects in group 3 (48% boys, age 5.5 ± 0.5 months) completed the study. At T0, the weight z score was similar in group 1 (-0.74) and 2 (-0.76), with differences compared to group 3 (-0.17, P < 0.05). At T12, the weight z score value was similar between the 3 groups without significant differences. There were no significant changes in protein metabolism in children in groups 1 and 2. Long-term treatment with AAF is safe and allows adequate body growth in children with CMA.

African-American Fathers' Perspectives on Their Children's Health Education: A Qualitative, Exploratory Study.

PubMed

Odum, Mary; Smith, Matthew Lee; McKyer, E Lisako J

2014-01-01

To investigate African-American fathers' (AAF) perceptions regarding the applicability and need for their involvement as a health connection for their children and describe how participating fathers' behavior was affected by their attitudes, knowledge, and perceptions of their influence on their children's health. This exploratory study gathered data via semi-structured focus groups (n = 3) and thematically analyzed it utilizing a grounded theory approach. Participants included AAF (n = 20) with a mean age of 37 years (SD 11.79), with at least one child between 6 and 18 years old. Four major themes were revealed: (1) appropriate health education for participants' children (should first and foremost be delivered by parents); (2) participants' paternal health-related guidance approach (reactive, rather than proactive); (3) participants' perceived influences on health-related communication with their children (gender roles, efficacy constraints); and (4) paternal definitions of health (most often associated with diet). Understanding AAFs' perceived and desired role in their children's health edification can inform initiatives that actively engage these men, and nurture their level of involvement, to promote positive health behaviors among their children; this is necessary to realize their potential to actively improve the health of their children, families, and communities.

Two-Column Aerosol Project (TCAP) Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berg, Larry K

This study included the deployment of the Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Mobile Facility (AMF), ARM Mobile Aerosol Observing System (MAOS) and the ARM Aerial Facility (AAF). The study was a collaborative effort involving scientists from DOE national laboratories, NOAA, NASA, and universities. The AAF and MAOS were deployed for two approximately month-long Intensive Operational Periods (IOPs) conducted in June 2012 and February 2013. Seasonal differences in the aerosol chemical and optical properties observed using the AMF, AAF, and MAOS are presented in this report. The total mass loading of aerosol is found tomore » be much greater in the summer than in the winter, with the difference associated with greater amounts of organic aerosol. The mass fraction of organic aerosol is much reduced in the winter, when sulfate is the dominant aerosol type. Surprisingly, very little sea-salt aerosol was observed in the summer. In contrast, much more sea salt aerosol was observed in the winter. The mass loading of black carbon is nearly the same in both seasons. These differences lead to a relative increase in the aerosol light absorption in the winter and an associated decrease in observed single-scattering albedo. Measurements of aerosol mixing state were made using a single-particle mass spectrometer, which showed that the majority of the summertime aerosol consisted of organic compounds mixed with various amounts of sulfate. A number of other findings are also summarized in the report, including: impact of aerosol layers aloft on the column aerosol optical depth; documentation of the aerosol properties at the AMF; differences in the aerosol properties associated with both columns, which are not systematic but reflect the complicated meteorological and chemical processes that impact aerosol as it is advected away from North America; and new instruments and data-processing techniques for measuring both aerosol and cloud properties that were deployed for the first time during the TCAP. Key lessons learned during TCAP include the need for closer coordination between the AMF, MAOS, and the AAF so that all AMF instruments can be online and functioning during the AAF IOPs. Based on experiences from TCAP, it is also important for instrument mentors, or other relevant individuals, to review data on a regular basis to ensure that data quality remains high during the entire deployment. TCAP was marked by two important meteorological events including the passage of Hurricane Sandy at the end of October 2012 and the occurrence of one of the largest New England blizzards in recorded history. During Sandy the AMF received some, generally minor, damage and was largely functional a short time after the storm. The blizzard led to extensive power outages on Cape Cod and a multi-day interruption of measurements by the AMF, MAOS, and AAF. In each case, however, the ARM Facilities were returned to service and functioning as soon as was reasonably possible.« less

Some ozone advanced oxidation processes to improve the biological removal of selected pharmaceutical contaminants from urban wastewater.

PubMed

Espejo, Azahara; Aguinaco, Almudena; Amat, Ana M; Beltrán, Fernando J

2014-01-01

Removal of nine pharmaceutical compounds--acetaminophen (AAF), antipyrine (ANT), caffeine (CAF), carbamazepine (CRB), diclofenac (DCF), hydrochlorothiazide (HCT), ketorolac (KET), metoprolol (MET) and sulfamethoxazole (SMX)-spiked in a primary sedimentation effluent of a municipal wastewater has been studied with sequential aerobic biological and ozone advanced oxidation systems. Combinations of ozone, UVA black light and Fe(III) or Fe3O4 constituted the chemical systems. During the biological treatment (hydraulic residence time, HRT = 24 h), only AAF and CAF were completely eliminated, MET, SMX and HCT reached partial removal rates and the rest of compounds were completely refractory. With any ozone advanced oxidation process applied, the remaining pharmaceuticals disappear in less than 10 min. Fe3O4 or Fe(III) photocatalytic ozonation leads to 35% mineralization compared to 13% reached during ozonation alone after about 30-min reaction. Also, biodegradability of the treated wastewater increased 50% in the biological process plus another 150% after the ozonation processes. Both untreated and treated wastewater was non-toxic for Daphnia magna (D. magna) except when Fe(III) was used in photocatalytic ozonation. In this case, toxicity was likely due to the ferryoxalate formed in the process. Kinetic information on ozone processes reveals that pharmaceuticals at concentrations they have in urban wastewater are mainly removed through free radical oxidation.

Revised Uniform Summary of Surface Weather Observations (RUSSWO) for Illesheim AAF, Uffenheim, Germany. Parts C, D & E

DTIC Science & Technology

1979-09-21

Final_______________ Germany 6. PERFORMING ORG. REPORT NUMBER 7 AUTHOR(a.) 8. CONTRACT OR GRANT NUMBER(s) 9 PERFORMING ORGANIZATION NAME AN4D ADDRESS 10 ...14 Apr61 N 49 28 E 010 23 1060 1130 10 -14 2 Sane AAF 5 Apr 61 Dec 70 Same Same 1066 Same 11-14 3 Sane Same Jan 71 Feb 79 Same Same Same Same 12 CNASE...Flm AAP_ _ _. "IMO XTATMS SAS Turn no-, ALL _____ _ {KNI$) 1-3 1-6 7- 10 It-16 17-21 22-27 28-33 34.40 41-47 0-35 -56 5 I WIND OR. -S.iiW PEED N , 7

Quality site seasonal report: Army Air Force Exchange Service Headquarters Building, SFBP 1343, August 1984 through May 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollock, E.O. Jr.

1987-10-15

The active solar Domestic Hot Water (DHW) system at the HQ Army-Air Force Exchange Service (AAFES) Building was designed and constructed as part of the Solar in Federal Buildings Programs (SFBP). This retrofitted system is one of eight of the systems in the SFBP selected for quality monitoring. The purpose of this monitoring effort is to document the performance of quality state-of-the-art solar systems in large federal building applications. The six-story HQ AAFES Building houses a cafeteria, officer's mess and club and office space for 2400 employees. The siphon-return drainback system uses 1147 ft/sup 2/ of Aircraftsman flat-plate collectors tomore » collect solar energy which is used to preheat domestic hot water. Solar energy is stored in a 1329-gallon tank and transferred to the hot water load through a heat exchanger located in the 356-gallon DHW preheat tank. Auxiliary energy is supplied by two gas fired boilers which boost the temperature to 130/sup 0/F before it is distributed to the load. Highlights of the performance of the HQ AAFES Building solar system during the monitoring period from August 1984 through May 1985 are presented in this report.« less

The use of performance-enhancing substances (doping) by athletes in Saudi Arabia

PubMed Central

Al Ghobain, Mohammed

2017-01-01

BACKGROUND: Data on doping violation in Saudi Arabia are scarce. Our aim was to investigate the Saudi experience of anti-doping and review all positive samples and adverse analytical findings (AAFs) of Saudi athletes. MATERIALS AND METHODS: This study analyzed databases of the Saudi Arabian Anti-Doping Committee from 2008 to May 2016. The samples originated from various sporting events and were collected in and outside sport competitions. The substances investigated were those included in the annual lists of prohibited substances produced by the World Anti-Doping Agency (WADA). All urine samples were tested in laboratories accredited by the WADA. Samples were declared positive if they contained any prohibited substance on the WADA list for that year. RESULTS: In 4482 urine samples tested, 141 positive samples (3.1%) and 195 AAFs of prohibited substances were detected. The prevalence of positive samples was highest in 2012 (6.6%) and lowest in 2015 (1%). The most prevalent prohibited substances detected were anabolic steroids (32.8%) and stimulants (27.6%). The most frequently detected compounds were amphetamines (22%) and tetrahydrocannabinol (12.8%). The highest prevalence of AAFs was in bodybuilders. CONCLUSION: The prevalence of doping in Saudi Arabia seems to be higher than western countries, but this needs to be confirmed with further research. PMID:28932159

Measuring Geophysical Parameters of the Greenland Ice Sheet using Airborne Radar Altimetry

NASA Technical Reports Server (NTRS)

Ferraro, Ellen J.; Swift. Calvin T.

1995-01-01

This paper presents radar-altimeter scattering models for each of the diagenetic zones of the Greenland ice sheet. AAFE radar- altimeter waveforms obtained during the 1991 and 1993 NASA multi-sensor airborne altimetry experiments over Greenland reveal that the Ku-band return pulse changes significantly with the different diagenetic zones. These changes are due to varying amounts of surface and volume scattering in the return waveform. In the ablation and soaked zones, where surface scattering dominates the AAFE return, geophysical parameters such as rms surface height and rms surface slope are obtained by fitting the waveforms to a surface-scattering model. Waveforms from the percolation zone show that the sub-surface ice features have a much more significant effect on the return pulse than the surrounding snowpack. Model percolation waveforms, created using a combined surface- and volume-scattering model and an ice-feature distribution obtained during the 1993 field season, agree well with actual AAFE waveforms taken in the same time period. Using a combined surface- and volume-scattering model for the dry-snow-zone return waveforms, the rms surface height and slope and the attenuation coefficient of the snowpack are obtained. These scattering models not only allow geophysical parameters of the ice sheet to be measured but also help in the understanding of satellite radar-altimeter data.

The use of performance-enhancing substances (doping) by athletes in Saudi Arabia.

PubMed

Al Ghobain, Mohammed

2017-01-01

Data on doping violation in Saudi Arabia are scarce. Our aim was to investigate the Saudi experience of anti-doping and review all positive samples and adverse analytical findings (AAFs) of Saudi athletes. This study analyzed databases of the Saudi Arabian Anti-Doping Committee from 2008 to May 2016. The samples originated from various sporting events and were collected in and outside sport competitions. The substances investigated were those included in the annual lists of prohibited substances produced by the World Anti-Doping Agency (WADA). All urine samples were tested in laboratories accredited by the WADA. Samples were declared positive if they contained any prohibited substance on the WADA list for that year. In 4482 urine samples tested, 141 positive samples (3.1%) and 195 AAFs of prohibited substances were detected. The prevalence of positive samples was highest in 2012 (6.6%) and lowest in 2015 (1%). The most prevalent prohibited substances detected were anabolic steroids (32.8%) and stimulants (27.6%). The most frequently detected compounds were amphetamines (22%) and tetrahydrocannabinol (12.8%). The highest prevalence of AAFs was in bodybuilders. The prevalence of doping in Saudi Arabia seems to be higher than western countries, but this needs to be confirmed with further research.

Exploring flavour-producing core microbiota in multispecies solid-state fermentation of traditional Chinese vinegar

PubMed Central

Wang, Zong-Min; Lu, Zhen-Ming; Shi, Jin-Song; Xu, Zheng-Hong

2016-01-01

Multispecies solid-state fermentation (MSSF), a natural fermentation process driven by reproducible microbiota, is an important technique to produce traditional fermented foods. Flavours, skeleton of fermented foods, was mostly produced by microbiota in food ecosystem. However, the association between microbiota and flavours and flavour-producing core microbiota are still poorly understood. Here, acetic acid fermentation (AAF) of Zhenjiang aromatic vinegar was taken as a typical case of MSSF. The structural and functional dynamics of microbiota during AAF process was determined by metagenomics and favour analyses. The dominant bacteria and fungi were identified as Acetobacter, Lactobacillus, Aspergillus, and Alternaria, respectively. Total 88 flavours including 2 sugars, 9 organic acids, 18 amino acids, and 59 volatile flavours were detected during AAF process. O2PLS-based correlation analysis between microbiota succession and flavours dynamics showed bacteria made more contribution to flavour formation than fungi. Seven genera including Acetobacter, Lactobacillus, Enhydrobacter, Lactococcus, Gluconacetobacer, Bacillus and Staphylococcus were determined as functional core microbiota for production of flavours in Zhenjiang aromatic vinegar, based on their dominance and functionality in microbial community. This study provides a perspective for bridging the gap between the phenotype and genotype of ecological system, and advances our understanding of MSSF mechanisms in Zhenjiang aromatic vinegar. PMID:27241188

Exploring flavour-producing core microbiota in multispecies solid-state fermentation of traditional Chinese vinegar.

PubMed

Wang, Zong-Min; Lu, Zhen-Ming; Shi, Jin-Song; Xu, Zheng-Hong

2016-05-31

Multispecies solid-state fermentation (MSSF), a natural fermentation process driven by reproducible microbiota, is an important technique to produce traditional fermented foods. Flavours, skeleton of fermented foods, was mostly produced by microbiota in food ecosystem. However, the association between microbiota and flavours and flavour-producing core microbiota are still poorly understood. Here, acetic acid fermentation (AAF) of Zhenjiang aromatic vinegar was taken as a typical case of MSSF. The structural and functional dynamics of microbiota during AAF process was determined by metagenomics and favour analyses. The dominant bacteria and fungi were identified as Acetobacter, Lactobacillus, Aspergillus, and Alternaria, respectively. Total 88 flavours including 2 sugars, 9 organic acids, 18 amino acids, and 59 volatile flavours were detected during AAF process. O2PLS-based correlation analysis between microbiota succession and flavours dynamics showed bacteria made more contribution to flavour formation than fungi. Seven genera including Acetobacter, Lactobacillus, Enhydrobacter, Lactococcus, Gluconacetobacer, Bacillus and Staphylococcus were determined as functional core microbiota for production of flavours in Zhenjiang aromatic vinegar, based on their dominance and functionality in microbial community. This study provides a perspective for bridging the gap between the phenotype and genotype of ecological system, and advances our understanding of MSSF mechanisms in Zhenjiang aromatic vinegar.

Auditory Masking Effects on Speech Fluency in Apraxia of Speech and Aphasia: Comparison to Altered Auditory Feedback

PubMed Central

Haley, Katarina L.

2015-01-01

Purpose To study the effects of masked auditory feedback (MAF) on speech fluency in adults with aphasia and/or apraxia of speech (APH/AOS). We hypothesized that adults with AOS would increase speech fluency when speaking with noise. Altered auditory feedback (AAF; i.e., delayed/frequency-shifted feedback) was included as a control condition not expected to improve speech fluency. Method Ten participants with APH/AOS and 10 neurologically healthy (NH) participants were studied under both feedback conditions. To allow examination of individual responses, we used an ABACA design. Effects were examined on syllable rate, disfluency duration, and vocal intensity. Results Seven of 10 APH/AOS participants increased fluency with masking by increasing rate, decreasing disfluency duration, or both. In contrast, none of the NH participants increased speaking rate with MAF. In the AAF condition, only 1 APH/AOS participant increased fluency. Four APH/AOS participants and 8 NH participants slowed their rate with AAF. Conclusions Speaking with MAF appears to increase fluency in a subset of individuals with APH/AOS, indicating that overreliance on auditory feedback monitoring may contribute to their disorder presentation. The distinction between responders and nonresponders was not linked to AOS diagnosis, so additional work is needed to develop hypotheses for candidacy and underlying control mechanisms. PMID:26363508

Effectiveness of Two Web-Based Interventions for Chronic Cancer-Related Fatigue Compared to an Active Control Condition: Results of the "Fitter na kanker" Randomized Controlled Trial.

PubMed

Bruggeman-Everts, Fieke Z; Wolvers, Marije D J; van de Schoot, Rens; Vollenbroek-Hutten, Miriam M R; Van der Lee, Marije L

2017-10-19

Approximately one third of all patients who have been successfully treated for cancer suffer from chronic cancer-related fatigue (CCRF). Effective and easily accessible interventions are needed for these patients. The current paper reports on the results of a 3-armed randomized controlled trial investigating the clinical effectiveness of two different guided Web-based interventions for reducing CCRF compared to an active control condition. Severely fatigued cancer survivors were recruited via online and offline channels, and self-registered on an open-access website. After eligibility checks, 167 participants were randomized via an embedded automated randomization function into: (1) physiotherapist-guided Ambulant Activity Feedback (AAF) therapy encompassing the use of an accelerometer (n=62); (2) psychologist-guided Web-based mindfulness-based cognitive therapy (eMBCT; n=55); or (3) an unguided active control condition receiving psycho-educational emails (n=50). All interventions lasted nine weeks. Fatigue severity was self-assessed using the Checklist Individual Strength - Fatigue Severity subscale (primary outcome) six times from baseline (T0b) to six months (T2). Mental health was self-assessed three times using the Hospital Anxiety and Depression Scale and Positive and Negative Affect Schedule (secondary outcome). Treatment dropout was investigated. Multiple group latent growth curve analysis, corrected for individual time between assessments, showed that fatigue severity decreased significantly more in the AAF and eMBCT groups compared to the psycho-educational group. The analyses were checked by a researcher who was blind to allocation. Clinically relevant changes in fatigue severity were observed in 66% (41/62) of patients in AAF, 49% (27/55) of patients in eMBCT, and 12% (6/50) of patients in psycho-education. Dropout was 18% (11/62) in AAF, mainly due to technical problems and poor usability of the accelerometer, and 38% (21/55) in eMBCT, mainly due to the perceived high intensity of the program. Both the AAF and eMBCT interventions are effective for managing fatigue severity compared to receiving psycho-educational emails. Trialregister.nl NTR3483; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3483 (Archived by WebCite at http://www.webcitation.org/6NWZqon3o). ©Fieke Z. Bruggeman-Everts, Marije D. J. Wolvers, Rens van de Schoot, Miriam M. R. Vollenbroek-Hutten, Marije L. Van der Lee. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.10.2017.

Anxiety about professional future among young doctors.

PubMed

Bolanowski, Wojciech

2005-01-01

The interest is focused on today's interns who will soon become an essential part of the health care system. Obstacles they perceive at the beginning of the career may encourage them or, inversely, impede their professional development, enhance professional burnout or even lead to change of the profession. International literature, comprising publications on the situation in ten European countries, Canada and the USA, is reviewed. Numerous considerations have encouraged some attempts to measure "anxiety about professional future" (AAF). Seven factors that induce anxiety about professional future among students and young doctors are listed and briefly discussed: 1) Difficulties in getting a job and growing anxiety for maintaining the job; 2) Low wages; 3) Negative impact of work on private and family life, in particular, a conflict between the professional role and mother's role; 4) Excessive level of organizational stress; 5) Lack of (individual) resources to cope with stress; 6) Institutional and financial limitations for professional development; and 7) Worldwide evolution of the professional role and the status of doctor. A questionnaire was developed by the author and answers were collected from a representative sample of Polish interns (about 1000) and a small sample of French interns. A scale for measuring the anxiety was built with use of factor analysis. The resulting scale called AAF has proved to have good statistical properties. The mean value of the anxiety indicator proved to be high in Poland. Interns who are familiar with the doctor's daily duties, who feel economically independent and who have good self-valuation of the practical skills are characterized by a lower level of anxiety. AAF values in a sample of French interns was dramatically lower than those characteristic of Polish interns. The values of AAF for the interns can be related to the intensity of stress-inducing factors in the professional environment. Very high AAF values can stem from an excessive professional stress that may have a negative impact on individual careers and the whole health care system in Poland. Appropriate changes in the curriculum of medical studies (accompanied by legal regulations) might reduce excessive anxiety about future in graduating doctors in Poland. Such changes could include: (a) a greater involvement of students in the examination and treatment of patients and in "daily life" in health care institutions; (b) making more practice (or performing medical procedures) obligatory; (c) creating better opportunities to earn living in the medical professions (by performing procedures or by assisting professionals); and (d) making efforts in the field of practical education more rewarding (e.g., introducing rating for practice and incorporating it into fellowship schemes).

32 CFR 552.98 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REGULATIONS AFFECTING MILITARY RESERVATIONS Firearms and Weapons § 552.98 Purpose. This regulation establishes... dangerous weapons and instruments on Fort Stewart/Hunter Army Airfield (AAF) installations. ...

32 CFR 552.98 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REGULATIONS AFFECTING MILITARY RESERVATIONS Firearms and Weapons § 552.98 Purpose. This regulation establishes... dangerous weapons and instruments on Fort Stewart/Hunter Army Airfield (AAF) installations. ...

Fort Wainwright, Wainwright AAF, Alaska, Limited Surface Observations Climatic Summary (LISOCS).

DTIC Science & Technology

1983-10-13

1 - 13.6 18I.2j __ 18.2 2? TOAL __6 1_ 20_ __a ._ oil __ 1. 273 - -------------------- - - - - - - ---- -- TOTALS~~~~ .. 0. 22. . 0 8 273 ( USFITA...AAF AK 70-03 J Su.. SAM".. m". ~Sr ALL WEATHE[R 21OC-230 (ENTS) 1 .3 4-6 7-10 11.16 17 .21 22 .27 28.33 34.40 41t56.3~ 6 % WIND oil . SPEWD NNE .7 is__...6 I F- 10 F1 JAA (KNTS) 1I 4. ’ -1 1.16 17.-21 22.-27 26.-33 24.-40 41 -47 46 -S 53 56 % WIND oil SPEED N*6 1.31 .4 .21 2.? 3.2 tN 2.’ri 2.91 2.7 8.1_

32 CFR 536.146 - Claims against nonappropriated fund employees-generally.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) activities. NAF activities include NAF or Army and Air Force Exchange Service (AAFES) facilities, post exchanges, bowling centers, officers and noncommissioned officers' clubs, and other facilities located on...

32 CFR 536.146 - Claims against nonappropriated fund employees-generally.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) activities. NAF activities include NAF or Army and Air Force Exchange Service (AAFES) facilities, post exchanges, bowling centers, officers and noncommissioned officers' clubs, and other facilities located on...

32 CFR 536.146 - Claims against nonappropriated fund employees-generally.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) activities. NAF activities include NAF or Army and Air Force Exchange Service (AAFES) facilities, post exchanges, bowling centers, officers and noncommissioned officers' clubs, and other facilities located on...

32 CFR 536.146 - Claims against nonappropriated fund employees-generally.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) activities. NAF activities include NAF or Army and Air Force Exchange Service (AAFES) facilities, post exchanges, bowling centers, officers and noncommissioned officers' clubs, and other facilities located on...

32 CFR 536.146 - Claims against nonappropriated fund employees-generally.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) activities. NAF activities include NAF or Army and Air Force Exchange Service (AAFES) facilities, post exchanges, bowling centers, officers and noncommissioned officers' clubs, and other facilities located on...

32 CFR 552.101 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... knives with a blade length of more than 3 inches. Swords, sabers, and machetes with sharpened blades. (8... sabers within the confines of Fort Stewart and Hunter AAF when used strictly for display and ceremonies...

32 CFR 552.101 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... knives with a blade length of more than 3 inches. Swords, sabers, and machetes with sharpened blades. (8... sabers within the confines of Fort Stewart and Hunter AAF when used strictly for display and ceremonies...

32 CFR 552.101 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... knives with a blade length of more than 3 inches. Swords, sabers, and machetes with sharpened blades. (8... sabers within the confines of Fort Stewart and Hunter AAF when used strictly for display and ceremonies...

32 CFR 552.101 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... knives with a blade length of more than 3 inches. Swords, sabers, and machetes with sharpened blades. (8... sabers within the confines of Fort Stewart and Hunter AAF when used strictly for display and ceremonies...

32 CFR 552.101 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... knives with a blade length of more than 3 inches. Swords, sabers, and machetes with sharpened blades. (8... sabers within the confines of Fort Stewart and Hunter AAF when used strictly for display and ceremonies...

Developing a method to derive alcohol-attributable fractions for HIV/AIDS mortality based on alcohol's impact on adherence to antiretroviral medication

PubMed Central

2011-01-01

Background Alcohol consumption is causally linked to nonadherence to antiretroviral treatment that in turn causes an increase in HIV/AIDS mortality. This article presents a method to calculate the percentage of HIV/AIDS deaths attributable to alcohol consumption and the associated uncertainty. Methods By combining information on risk relations from a number of published sources, we estimated alcohol-attributable fractions (AAFs) of HIV/AIDS in a stepwise procedure. First, we estimated the effect of alcohol consumption on adherence to antiretroviral treatment, and then we combined this estimate with the impact of nonadherence on death. The 95% uncertainty intervals were computed by estimating the variance of the AAFs using Taylor series expansions of one and multiple variables. AAFs were determined for each of the five Global Burden of Disease regions of Africa, based on country-specific treatment and alcohol consumption data from 2005. Results The effects of alcohol on HIV/AIDS in the African Global Burden of Disease regions range from 0.03% to 0.34% for men and from 0% to 0.17% for women, depending on region and age category. The detrimental effect of alcohol consumption was statistically significant in every region and age category except for the North Africa/Middle East region. Conclusions Although the method has its limitations, it was shown to be feasible and provided estimates of the impact of alcohol use on the mortality outcome of HIV/AIDS. PMID:21320310

Hunter Liggett AAF, Jolon, California. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1967-10-23

00.0,00.0100.0100.0.00.0 ,o00.01 TOTA NUB OFOSRATOS0 300OW FORM 10*45 00(Dot 000 00,SO)601. oRVOJ KDI.ION OF T,0llS PORN ARE OBSOLETE 4~~~~ ~~~ D4 - --. -- 44...e.....Iteonoto0 1001000 fq’ 0 o --- _ r-0n 200 9o~ 0 60*01000 ,01060104 00* aootooo .06 I. 1 66,0000.1 too 993100010:OILO,&100*IOC-eoloooOO* DOG ...PREVIOUS EDITIONS OP THS PORN . ARE ONSOLETE ,-.- N -- ’ : ’ " ’ ’ "" ... .... .. N N " .. . .. . . . .i gI NN....N.-. 2- -1 2 s 1: ii2- •-w I ~.N J44

78 FR 34608 - Proposed Establishment of Class D Airspace; Bryant AAF, Anchorage, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... Association (AOPA), Alaska Airmen's Association (AAA), and the Alaskan Aviation Safety Foundation (AASF). One... D airspace. The AAA requested additional time to review the proposal and that the entire composition...

32 CFR 842.136 - Claim payments and deposits.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Claims payable for $2500 or less: AAFES Operations Center (OSC-AC), 2727 LBJ Highway, Dallas TX 75266-0320. (b) Civilian base restaurants and civilian welfare NAFIs: (1) For more than $100: Army and Air...

Marshall AAF, Manhattan, Kansas. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1980-02-25

TQACE 1.8 6.7 66-4 -5 -6 -- .0 § Td .0 .C .. 2 . -7 1.1 TRAM0 .6 TRACE .0 :0 :0’ :0 0 : TRACE- S 3. 0: 2.4! T .0 .0 .0 .0 .0 .0 TRACE 4.1 4 .1 TjWU TRCti...I’ / / // / ’ L!-OL LLitCf- ILOIY A.. CH L.t r TPSYCHROMETRIC SUMMARY A. LdA Td ~ ; tA,-VICLI/4AC 1 4 -IRSHHALL AAF KS (j-t V-7 v sTATON...82𔃻. 98z/10. 74!, 9.505 3.2bO I.959 d.2e,’,IU1921U.94411.T13?1...b 1b I ?1 00 TOTAL1OBS lUt 93 1! 112 1 99U 1014: 98W: 1U2 1: 1U11 98 8 L V 9 L 1q3 1

ARC-1969-A-17432

NASA Image and Video Library

1952-08-05

NACA Photographer (DFRC) ERF-61C-1-NO (AAF43-8330 NACA 330, NACA 111) mother ship for RECOVERABLE-BODY TECHNIQUE. Transonic Model Testing. Fig. 13 NASA SP-1998-3300 Flight Research at Ames: 57 Years of Development and Validation of Aeronautical Technology

Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric probe.

PubMed

Darroudi, F; Meijers, C M; Hadjidekova, V; Natarajan, A T

1996-09-01

In human hepatoma (Hep G2) cells and peripheral blood lymphocytes (HPBL) the cytokinesis-blocked micronuclei (MN) and fluorescent in situ hybridization (FISH) assays were applied to study aneugenic and clastogenic potentials of X-rays, directly and indirectly acting chemicals. Induction of MN was studied in vitro following treatment with X-rays, directly acting chemicals, such as methylmeth-anesulphonate (MMS), colchicine (COL), vincristine sulphate (VCS) and vinblastine sulphate (VBS), and indirectly acting agents, such as cyclophosphamide (CP), hexamethylphosphoramide (HMPA), 2-acetylaminofluorene (2-AAF) and 4-acetylaminofluorene (4-AAF). Depending on the presence of the fluorescent signal in the MN following FISH with a human DNA centromeric probe, MN in the binucleated Hep G2 cells and lymphocytes were scored as centromere-positive or centromere-negative, representing an aneugenic and clastogenic event respectively. In the controls approximately 50% of spontaneously occurring MN were centromere-positive. Treatment of human hepatoma cells and HPBL (in vitro) with potent aneugens such as COL, VCS and VBS increased the number of MN in a dose-dependent manner; of these 75-93% were centromere-positive. X-irradiation induced MN in a dose-related manner in binucleated Hep G2 cells and HPBL, of which 33-40% were centromere-positive, which demonstrates the significant aneugenic potentials of X-rays. Strong clastogenic activity was observed with MMS and frequency of centromere-positive MN was low: approximately 20 and 30% for HPBL and Hep G2 cells respectively. In Hep G2 cells significant aneugenic activity was found with indirectly acting promutagens/procarcinogens such as HMPA and 2-AAF, in contrast to CP, which came out as a potent clastogen. The non-carcinogen 4-AAF was not able to induce an increase in the frequency of MN in Hep G2 cells. All indirectly acting chemicals tested came out negative when HPBL were used as targets for DNA damage. The results presented correlate positively with data from in vivo assays and indicate that the Hep G2 cell system is a suitable bioactivation system (in vitro) for evaluating the clastogenic and aneugenic potentials of chemicals which require exogenous metabolic activations in order to exert their mutagenic potential.

China takes microgravity work to new heights | Science | AAAS

Science.gov Websites

China takes microgravity work to new heights By Dennis Normile Apr. 5, 2016 , 2:00 PM China's space :10.1126/science.aaf9876 Dennis Normile More from News illustration of GOES-17 Cooling failure threatens

Evaluation of AAFE apparatus to measure residual and transient convection in zero-gravity

NASA Technical Reports Server (NTRS)

Ruff, R. C.; Facemire, B. R.; Witherow, W. K.

1978-01-01

An evaluation apparatus which photographs convective and diffusive flows in crystal growth experiments is presented. Results in the following catagories are reported: (1) Human factors; (2) Electrical and mechanical; (3) Optical performance; and (4) Thermal performance.

Summary of Independent Assessment of the Afghan National Security Forces

DTIC Science & Technology

2014-02-01

Afghan National Police (ANP), which are the Afghan Border Police ( ABP ), Afghan National Civil Order Police (ANCOP), Afghan Uniform Police (AUP...intentionally left blank 43 Acronyms AACP Afghan Anti-Crime Police AAF Afghan Air Force ABP Afghan Border Police ALP Afghan

Genome-wide detection of natural selection in African Americans pre- and post-admixture

PubMed Central

Jin, Wenfei; Xu, Shuhua; Wang, Haifeng; Yu, Yongguo; Shen, Yiping; Wu, Bailin; Jin, Li

2012-01-01

It is particularly meaningful to investigate natural selection in African Americans (AfA) due to the high mortality their African ancestry has experienced in history. In this study, we examined 491,526 autosomal single nucleotide polymorphisms (SNPs) genotyped in 5210 individuals and conducted a genome-wide search for selection signals in 1890 AfA. Several genomic regions showing an excess of African or European ancestry, which were considered the footprints of selection since population admixture, were detected based on a commonly used approach. However, we also developed a new strategy to detect natural selection both pre- and post-admixture by reconstructing an ancestral African population (AAF) from inferred African components of ancestry in AfA and comparing it with indigenous African populations (IAF). Interestingly, many selection-candidate genes identified by the new approach were associated with AfA-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to a new environment. CD36 and HBB, whose mutations confer a degree of protection against malaria, were also located in the highly differentiated regions between AAF and IAF. Further analysis showed that the frequencies of alleles protecting against malaria in AAF were lower than those in IAF, which is consistent with the relaxed selection pressure of malaria in the New World. There is no overlap between the top candidate genes detected by the two approaches, indicating the different environmental pressures AfA experienced pre- and post-population admixture. We suggest that the new approach is reasonably powerful and can also be applied to other admixed populations such as Latinos and Uyghurs. PMID:22128132

Mechanistic link between uptake of sulfonamides and bacteriostatic effect: model development and application to experimental data from two soil microorganisms.

PubMed

Focks, Andreas; Klasmeier, Jörg; Matthies, Michael

2010-07-01

Sulfonamides (SA) are antibiotic compounds that are widely used as human and veterinary pharmaceuticals. They are not rapidly biodegradable and have been detected in various environmental compartments. Effects of sulfonamides on microbial endpoints in soil have been reported from laboratory incubation studies. Sulfonamides inhibit the growth of sensitive microorganisms by competitive binding to the dihydropteroate-synthase (DHPS) enzyme of folic acid production. A mathematical model was developed that relates the extracellular SA concentration to the inhibition of the relative bacterial growth rate. Two factors--the anionic accumulation factor (AAF) and the cellular affinity factor (CAF)--determine the effective concentration of an SA. The AAF describes the SA uptake into bacterial cells and varies with both the extra- and intracellular pH values and with the acidic pKa value of an SA. The CAF subsumes relevant cellular and enzyme properties, and is directly proportional to the DHPS affinity constant for an SA. Based on the model, a mechanistic dose-response relationship is developed and evaluated against previously published data, where differences in the responses of Pseudomonas aeruginosa and Panthoea agglomerans toward changing medium pH values were found, most likely as a result of their diverse pH regulation. The derived dose-response relationship explains the pH and pKa dependency of mean effective concentration values (EC50) of eight SA and two soil bacteria based on AAF and CAF values. The mathematical model can be used to extrapolate sulfonamide effects to other pH values and to calculate the CAF as a pH-independent measure for the SA effects on microbial growth. Copyright (c) 2010 SETAC.

Steroid profile and IRMS analysis of musk administration for doping control.

PubMed

Wang, Jingzhu; He, Yi; Liu, Xin; Yang, Zhiyong; Yang, Wenning

2017-11-01

Musk, the dried secretion of the musk pod (sac) of adult male musk deer, has been used as traditional Chinese Medicine (TCM) in China and south-east Asian countries for thousands of years. Due to the anabolic steroid component in this TCM, musk preparations have been included in the list of medical products containing prohibited substances employed for doping by the State Food and Drug Administration of China. The application of musk pod formulation was claimed to be responsible for some adverse analytical findings (AAFs) in the 2011 FIFA Women's World Cup. Our preliminary study has suggested that musk ingestion did not lead to AAFs of doping control with the single dosage of 100 mg. However, the influences of musk administration in large and multi dosage are still unclear. The aim of this study is to further investigate the influences of musk administration for doping control. Wild and domestic deer musk samples were collected. The concentrations and δ 13 C-values of steroids in musk were analyzed. In an excretion study, 200 and 100 mg of wild and domestic deer musk samples were administrated by 29 subjects, respectively. Fluctuations in steroid profile could be observed, and the ratio of 5α-androstane-3α,17β-diol to 5β-androstane-3α,17β-diol was more sensitive than other parameters. In the IRMS test, the ∆Δδ 13 C-value between endogenous reference compound and etiocholanolone was a sensitive parameter, and AAFs were obtained. It is the first time to confirm with excretion study that musk administration could lead to positive result of doping control. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Randomized Trial of a Yogurt-type Amino Acid-based Formula in Infants and Children With Severe Cow's Milk Allergy.

PubMed

Payot, François; Lachaux, Alain; Lalanne, Florent; Kalach, Nicolas

2018-01-01

Evaluation of a spoon-fed amino acid-based formula (AAF) with a yogurt-type texture compared to the reference oral liquid formula (Neocate). Phase III/IV, prospective, randomized (1:1), open-label, multicenter study in infants/young children (6-36 months) with severe cow's milk protein allergy (CMA) who had consumed AAF for ≥1 month before the study. Patients received reference+test formula (Neocate with a yogurt-type texture for spoon-feeding: group 1) or reference formula (group 2) for 28 days. The study formulae were integrated into the patients' usual daily diet. Efficacy on Day 0, 14, and 28 was assessed primarily in terms of symptoms associated with CMA. The evolution of symptoms, amount of formula consumed, nutritional and energy intake, anthropometric data, and tolerability were also assessed. The incidence of CMA symptoms was similar in each group (P > 0.05) on day 0, 14, and 28. For specific symptoms, there was little change from day 0 and no significant difference between groups for incidence on day 0 or evolution at day 14 or 28. There was no difference in formula consumption (day 0-day 28) between groups (P = 0.90), but nutritional value was generally higher for group 1 and calcium intake was statistically higher for group 1 (P < 0.05). Weight-for-height, weight-for age, and body mass index-for-age z scores were higher for group 1 than group 2 (P < 0.05). Both formulae were well tolerated. There was no difference in efficacy, formula consumption, and tolerability between the new spoon-fed yogurt-type AAF formula and the reference formula, whereas significantly higher calcium intake was achieved with the new formula.

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: PAINT OVERSPRAY ARRESTOR, AAF INTERNATIONAL DRI-PAK 40-45%

EPA Science Inventory

Paint overspray arrestors (POAs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the particle filtration efficiency as a function of size for particles smaller than...

Final Report of Research Conducted For DE-AI02-08ER64546

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrick Minnis

2012-03-28

Research was conducted for 3-4 years to use ARM data to validate satellite cloud retrievals and help the development of improved techniques for remotely sensing clouds and radiative fluxes from space to complement the ARM surface measurement program. This final report summarizes the results and publications during the last 2 years of the studies. Since our last report covering the 2009 period, we published four papers that were accepted during the previous reporting period and revised and published a fifth one. Our efforts to intercalibrate selected channels on several polar orbiting and geostationary satellite imagers, which are funded in partmore » by ASR, resulted in methods that were accepted as part of the international Global Space-based Intercalibration System (GSICS) calibration algorithms. We developed a new empirical method for correcting the spectral differences between comparable channels on various imagers that will be used to correct the calibrations of the satellite data used for ARM. We documented our cloud retrievals for the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-Rex; ARM participated with an AAF contribution) in context of the entire experiment. We used our VOCALS satellite data along with the aircraft measurements to better understand the relationships between aerosols and liquid water path in marine stratus clouds. We continued or efforts to validate and improve the satellite cloud retrievals for ARM and using ARM data to validate retrievals for other purposes.« less

Laboratory calibration of AAFE radiometer/scatterometer (RADSCAT)

NASA Technical Reports Server (NTRS)

Schroeder, L. C.; Jones, W. L., Jr.; Mitchell, J. L.

1976-01-01

A brief description of the electrical and mechanical instrument configuration, followed by an extensive discussion of laboratory tests and results are contained herein. This information is required to provide parameters for data reduction, and a basis for analysis of the measurement errors in data taken with this instrument.

78 FR 52083 - Amendment of Class E Airspace; Fort Polk, LA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

...) Standard Instrument Approach Procedures at Polk Army Airfield (AAF). The airport's geographic coordinates are also adjusted. This action enhances the safety and management of Instrument Flight Rule (IFR... extending upward from 700 feet above the surface to accommodate new standard instrument approach procedures...

77 FR 8869 - Radio Broadcasting Services; AM or FM Proposals To Change the Community of License

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

..., Facility ID 21416, BP-20090226AAF, From FERNDALE, WA, To POINT ROBERTS, WA; CUMULUS LICENSING LLC, Station...://svartifoss2.fcc.gov/prod/cdbs/pubacc/prod/cdbs_pa.htm . A copy of this application may also be purchased from...

32 CFR Appendix F to Part 516 - Glossary

Code of Federal Regulations, 2010 CFR

2010-07-01

... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Pt. 516, App. F Appendix F to Part 516—Glossary Abbreviations AAFES: Army and Air Force... danger to public health or safety. Information Exempt From Release To The Public Those categories of...

DOSE-DEPENDENCY OF 2-ACETYLAMINOFLUORENE BINDING TO LIVER DNA AND HEMOGLOBIN IN MICE AND RATS

EPA Science Inventory

The carcinogenic activity of 2-acetylaminofluorene (2-AAF) in mice and rats has been accurately described so that it is a suitable archetypical chemical for investigations of parameters of cross-species variation. The results of the study supported a pharmacokinetic model that re...

78 FR 33019 - Proposed Amendment of Class E Airspace; Commerce, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... accommodate new Standard Instrument Approach Procedures (SIAPs) at Commerce Municipal Airport (AAF). The FAA is taking this action to enhance the safety and management of Instrument Flight Rules (IFR... airport to provide adequate controlled airspace for the safety and management of IFR operations at the...

African-American Female Student Experiences in Community College

ERIC Educational Resources Information Center

Dozier, Nedra

2016-01-01

This is a mixed method study focusing on African-American Female (AAF) student experiences and success in the community college. This study was focused at a large southeastern, comprehensive community college. A chi-squared analysis of extant data concerning questions from the Community College Survey for Student Engagement (CCSSE) instrument was…

32 CFR 516.22 - Miscellaneous reporting requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Miscellaneous reporting requirements. 516.22 Section 516.22 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL... transactions. (FAR and DFARS, 48 CFR parts 29 and 229). (2) Army and Air Force Exchange Service (AAFES...

Numbers Matter: Post-2014 Afghan National Security Force End Strength

DTIC Science & Technology

2013-03-01

Afghan Border Police ( ABP ), and the Afghan National Civil Order Police (ANCOP).16 Two other Afghan security organizations, which did not factor...Air Force (AAF), Afghan Border Police ( ABP ), and Afghan Uniform Police (AUP), is also a significant challenge to the legitimacy of the ANSF with the

Environmental Assessment: Construct New AAFES Shopping Center Shaw Air Force Base, South Carolina

DTIC Science & Technology

2008-10-01

water supply after conventional treatment, fishing and the survival and propagation of a balanced indigenous aquatic community of flora and fauna. No...arrow-head West Indian meadow-beauty Wild petunia Amphibians Northern cricket frog Reptiles Eastern coral snake Mammals Rafinesque’s big-eared

Terminal Forecast Reference Notebook for Hanau AAF, Germany.

DTIC Science & Technology

1983-04-22

Vogelsberg, just west of Fulda, rises to a prominence of 2359 feet. This is a singular feature of volcanic origin with the land rising up from small...near 2000 feet 50 miles south of Hanau. Farther to the southwest, on the west side of the Rhein River valley, are the Eifel Mountains. EFFECTS OF

Surface Observation Climatic Summaries (SOCS) for Simmons AAF, North Carolina

DTIC Science & Technology

1992-02-01

CHIRF, CLIMATIC APPLICATIONS, OL-A IIRLT~ M 8a. llS SCIRlTIUIC AND TCIICAL INFOlRMATIO 06 OCr ig• III USAFETAC/DS--92/267 - Page 2 REPORT DOCUMENTATION...B-2-1 0MIMLY TOTALS ................................................ B-2-2 DAILY EMM M ... M ........................................................ E-2-1 [INuS........................................................... E-2-2 MEA.N

75 FR 61993 - Amendment of Class E Airspace; Kwajalein Island, Marshall Islands, RMI

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

...) System from the legal description of the Class E airspace areas for Kwajalein Island, Bucholz AAF... action corrects the legal descriptions for the Class E airspace areas in the vicinity of the Marshall... and Rules Group, Office of System Operations Airspace and AIM, Federal Aviation Administration, 800...

76 FR 77111 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

..., 6500 South MacArthur Blvd., Oklahoma City, OK 73169 or 4. The National Archives and Records... to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html..., Amdt 3D, CANCELLED Fort Hood/Killeen, TX, Robert Gray AAF, RADAR-1, Orig New Market, VA, New Market...

Dissecting Choral Speech: Properties of the Accompanist Critical to Stuttering Reduction

ERIC Educational Resources Information Center

Kiefte, Michael; Armson, Joy

2008-01-01

The effects of choral speech and altered auditory feedback (AAF) on stuttering frequency were compared to identify those properties of choral speech that make it a more effective condition for stuttering reduction. Seventeen adults who stutter (AWS) participated in an experiment consisting of special choral speech conditions that were manipulated…

Stuttering in Adults: The Acoustic Startle Response, Temperamental Traits, and Biological Factors

ERIC Educational Resources Information Center

Alm, Per A.; Risberg, Jarl

2007-01-01

The purpose of this study was to investigate the relation between stuttering and a range of variables of possible relevance, with the main focus on neuromuscular reactivity, and anxiety. The explorative analysis also included temperament, biochemical variables, heredity, preonset lesions, and altered auditory feedback (AAF). An increased level of…

Fort Campbell AAF, Clarksville, Kentucky. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1975-07-10

3.1 1 1~ p) 2.6l 67 l 7 .7i .,o p 5,,1 29t,9 ,.4 .96 11 ,n1 l53 5.64 68, 0 1 7 , B .2 IAN 6 614 .69 ,e ,8 6,.9 3.8 , ( "/92 21 ,. 14, Ŗ,9 ,2 1. .9 . 9...61 0-14.5 (OL Al 1,tv."V$ ID~CNS 0 Tos ’Of. All oISsoL. .. ( DATA P"..C_. ’, td . Ch CI USAF ETAC CEILING VERSUS VISIBILITY L AIR ’lEAT-HE, SE’,VIC...99 8100,0100 0100-0100.01 7OTAL NUMBER OF OBSERVATIONS 2411 USAF ETAC Xr A,. 0-14-5 (OL A) m.fVr,.s 1W0T O FIO S FORM At( Oj$O.,tE - tD 5- -, A,4 4 5

A method for in vitro culture of rat Zymbal gland: use in mechanistic studies of benzene carcinogenesis in combination with 32P-postlabeling.

PubMed Central

Reddy, M V; Blackburn, G R; Irwin, S E; Kommineni, C; Mackerer, C R; Mehlman, M A

1989-01-01

Zymbal glands were excised bilaterally from the ear ducts of female Sprague-Dawley rats (three/group), minced into approximately four fragments per gland, and transferred into a microtiter plate containing 1.5 mL per well of Waymouth's tissue culture medium supplemented with fetal calf serum, hydrocortisone, insulin, and gentamicin. After addition of a test compound or solvent vehicle, plates were incubated for 6, 24, 48, or 96 hr at 37 degrees C in a humidified atmosphere of 5% CO2 in air. Tissue in culture for 6 hr was histologically indistinguishable from the freshly excised tissue, while that in culture for 24, 48, and 96 hr showed a progressive deterioration often with necrosis and/or squamous metaplasia. More pronounced deterioration was noted in samples treated with 750 or 1500 micrograms/mL of benzene. Using a nuclease P1-enhanced 32P-postlabeling assay, aromatic DNA adducts were detected in cultured Zymbal glands exposed for 48 hr to benzene and its derivatives, as well as to 7,12-dimethylbenzanthracene (DMBA) and 2-acetylaminofluorene (AAF). Benzene produced very low levels of adducts (0.5 adducts per 10(9) nucleotides), whereas its congeners produced relatively high levels of adducts (50-2000 lesions per 10(9) nucleotides), which decreased in the order benzoquinone greater than hydroquinone greater than phenol greater than benzenetriol greater than catechol. Each adduct profile overall was characteristic for the compound studied, suggesting the formation of compound-specific electrophiles. AAF and DMBA adducts were identical to those formed in vivo in animals. Our results show that the Zymbal glands are capable of metabolizing different carcinogens to DNA-reactive intermediates, a process that may be causally associated with tumor formation in vivo in this organ. Images FIGURE 3. A FIGURE 3. B FIGURE 3. C FIGURE 4. FIGURE 5. FIGURE 6. PMID:2507309

Adjusting for unrecorded consumption in survey and per capita sales data: quantification of impact on gender- and age-specific alcohol-attributable fractions for oral and pharyngeal cancers in Great Britain.

PubMed

Meier, Petra Sylvia; Meng, Yang; Holmes, John; Baumberg, Ben; Purshouse, Robin; Hill-McManus, Daniel; Brennan, Alan

2013-01-01

Large discrepancies are typically found between per capita alcohol consumption estimated via survey data compared with sales, excise or production figures. This may lead to significant inaccuracies when calculating levels of alcohol-attributable harms. Using British data, we demonstrate an approach to adjusting survey data to give more accurate estimates of per capita alcohol consumption. First, sales and survey data are adjusted to account for potential biases (e.g. self-pouring, under-sampled populations) using evidence from external data sources. Secondly, survey and sales data are aligned using different implementations of Rehm et al.'s method [in (2010) Statistical modeling of volume of alcohol exposure for epidemiological studies of population health: the US example. Pop Health Metrics 8, 1-12]. Thirdly, the impact of our approaches is tested by using our revised survey dataset to calculate alcohol-attributable fractions (AAFs) for oral and pharyngeal cancers. British sales data under-estimate per capita consumption by 8%, primarily due to illicit alcohol. Adjustments to survey data increase per capita consumption estimates by 35%, primarily due to under-sampling of dependent drinkers and under-estimation of home-poured spirits volumes. Before aligning sales and survey data, the revised survey estimate remains 22% lower than the revised sales estimate. Revised AAFs for oral and pharyngeal cancers are substantially larger with our preferred method for aligning data sources, yielding increases in an AAF from the original survey dataset of 0.47-0.60 (males) and 0.28-0.35 (females). It is possible to use external data sources to adjust survey data to reduce the under-estimation of alcohol consumption and then account for residual under-estimation using a statistical calibration technique. These revisions lead to markedly higher estimated levels of alcohol-attributable harm.

Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde.

PubMed

Kraynak, A R; Barnum, J E; Cunningham, C L; Ng, A; Ykoruk, B A; Bennet, B; Stoffregen, D; Merschman, M; Freeland, E; Galloway, S M

2015-07-01

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the ability of the assay to determine the genotoxicity of 2-acetylaminofluorene (AAF), azidothymidine (AZT), cisplatin (CPN), and isobutyraldehyde (IBA) in liver and glandular stomach of male Sprague-Dawley rats. Rats were given oral doses of test compound or control once daily for three days. High dose levels were approximately maximum tolerated doses and were based on preliminary range-finding studies. Tissues were harvested 3h after the final dose (48h after the initial dose). A bone marrow micronucleus assay (MN) was also conducted on the rats treated with AZT, CPN, and IBA. Acute toxic effects of treatment were determined primarily through histomorphologic analysis of liver and stomach but also by body weight and serum liver enzyme changes. The comet assay was conducted on fresh tissue preparations but frozen samples from two studies were also assayed. Statistically significant dose-related differences in comet % DNA in tail were found in liver and stomach for the genotoxin AZT and in liver for the genotoxin CPN, but not in liver or stomach for the non-genotoxin IBA. Statistically significant differences in % DNA in tail were measured in liver for the low and mid dose of the genotoxin AAF, but not the high dose. The comet assays of frozen liver suspensions from CPN- and AAF-treated rats yielded comparable results to the assays of fresh preparations. There were no indications of significant toxicity induced by any treatment. The micronucleus assay was positive for CPN and AZT and negative for IBA. In conclusion, the in vivo comet assay is capable of detecting genotoxic effects of a variety of chemicals and may fill an important role in the genotoxicity test battery. Copyright © 2015 Elsevier B.V. All rights reserved.

Comet assay evaluation of six chemicals of known genotoxic potential in rats.

PubMed

Hobbs, Cheryl A; Recio, Leslie; Streicker, Michael; Boyle, Molly H; Tanaka, Jin; Shiga, Atsushi; Witt, Kristine L

2015-07-01

As a part of an international validation of the in vivo rat alkaline comet assay (comet assay) initiated by the Japanese Center for the Validation of Alternative Methods (JaCVAM) we examined six chemicals for potential to induce DNA damage: 2-acetylaminofluorene (2-AAF), N-nitrosodimethylamine (DMN), o-anisidine, 1,2-dimethylhydrazine dihydrochloride (1,2-DMH), sodium chloride, and sodium arsenite. DNA damage was evaluated in the liver and stomach of 7- to 9-week-old male Sprague Dawley rats. Of the five genotoxic carcinogens tested in our laboratory, DMN and 1,2-DMH were positive in the liver and negative in the stomach, 2-AAF and o-anisidine produced an equivocal result in liver and negative results in stomach, and sodium arsenite was negative in both liver and stomach. 1,2-DMH and DMN induced dose-related increases in hedgehogs in the same tissue (liver) that exhibited increased DNA migration. However, no cytotoxicity was indicated by the neutral diffusion assay (assessment of highly fragmented DNA) or histopathology in response to treatment with any of the tested chemicals. Therefore, the increased DNA damage resulting from exposure to DMN and 1,2-DMH was considered to represent a genotoxic response. Sodium chloride, a non-genotoxic non-carcinogen, was negative in both tissues as would be predicted. Although only two (1,2-DMH and DMN) out of five genotoxic carcinogens produced clearly positive results in the comet assay, the results obtained for o-anisidine and sodium arsenite in liver and stomach cells are consistent with the known mode of genotoxicity and tissue specificity exhibited by these carcinogens. In contrast, given the known genotoxic mode-of-action and target organ carcinogenicity of 2-AAF, it is unclear why this chemical failed to convincingly increase DNA migration in the liver. Thus, the results of the comet assay validation studies conducted in our laboratory were considered appropriate for five out of the six test chemicals. Copyright © 2015 Elsevier B.V. All rights reserved.

Comet assay evaluation of six chemicals of known genotoxic potential in rats

PubMed Central

Hobbs, Cheryl A.; Recio, Leslie; Streicker, Michael; Boyle, Molly H.; Tanaka, Jin; Shiga, Atsushi; Witt, Kristine L.

2015-01-01

As a part of an International validation of the in vivo rat alkaline comet assay (comet assay) initiated by the Japanese Center for the Validation of Alternative Methods (JaCVAM) we examined six chemicals for potential to induce DNA damage: 2-acetylaminofluorene (2-AAF), N-nitrosodimethylamine (DMN), o-anisidine, 1,2-dimethylhydrazine dihydrochloride (1,2-DMH), sodium chloride, and sodium arsenite. DNA damage was evaluated in the liver and stomach of 7- to 9-week-old male Sprague Dawley rats. Of the five genotoxic carcinogens tested in our laboratory, DMN and 1,2-DMH were positive in the liver and negative in the stomach, 2-AAF and o-anisidine produced an equivocal result in liver and negative results in stomach, and sodium arsenite was negative in both liver and stomach. 1,2-DMH and DMN induced dose-related increases in hedgehogs in the same tissue (liver) that exhibited increased DNA migration. However, no cytotoxicity was indicated by the neutral diffusion assay (assessment of highly fragmented DNA) or histopathology in response to treatment with any of the tested chemicals. Therefore, the increased DNA damage resulting from exposure to DMN and 1,2-DMH was considered to represent a genotoxic response. Sodium chloride, a non-genotoxic non-carcinogen, was negative in both tissues as would be predicted. Although only two (1,2-DMH and DMN) out of five genotoxic carcinogens produced clearly positive results in the comet assay, the results obtained for o-anisidine and sodium arsenite in liver and stomach cells are consistent with the known mode of genotoxicity and tissue specificity exhibited by these carcinogens. In contrast, given the known genotoxic mode-of-action and target organ carcinogenicity of 2-AAF, it is unclear why this chemical failed to convincingly increase DNA migration in the liver. Thus, the results of the comet assay validation studies conducted in our laboratory were considered appropriate for five out of the six test chemicals. PMID:26212309

Production and characterization of alien chromosome additions in shallot (Allium cepa L. Aggregatum group) carrying extra chromosome(s) of Japanese bunching onion (A. fistulosum L.).

PubMed

Hang, Tran Thi Minh; Shigyo, Masayoshi; Yamauchi, Naoki; Tashiro, Yosuke

2004-10-01

First and second backcrosses of amphidiploid hybrids (2n = 4x = 32, genomes AAFF) between shallot (Allium cepa Aggregatum group) and A. fistulosum were conducted to produce A. cepa - A. fistulosum alien addition lines. When shallot (A. cepa Aggregatum group) was used as a pollinator, the amphidiploids and allotriploids set germinable BC(1) and BC(2) seeds, respectively. The 237 BC(1) plants mainly consisted of 170 allotriploids (2n = 3x = 24, AAF) and 42 hypo-allotriploids possessing 23 chromosomes, i.e., single-alien deletions (2n = 3x-1 = 23, AAF-nF). The single-alien deletions in the BC(1) progeny showed dwarfing characteristics and were discriminated from the allotriploids (2n = 24) and hyper-allotriploids (2n = 25) by means of flow cytometric analysis. The chromosome numbers of 46 BC(2) seedlings varied from 16 to 24. Eight monosomic additions (2n = 2x+1 = 17, AA+nF) and 20 single-alien deletions were found in these BC(2) seedlings. Consequently, six kinds of A. cepa - A. fistulosum alien chromosome additions possessing different chromosome numbers (2n = 17, 18, 20, 21, 22, 23) were recognized in the BC(1) and BC(2) populations. A total of 79 aneuploids, including 62 single-alien deletions, were analyzed by a chromosome 6F-specific isozyme marker (Got-2) in order to recognize its existence in their chromosome complements. This analysis revealed that two out of 62 single-alien deletions did not possess 6F. One (AAF-6F) out of the possible eight single-alien deletions could be identified at first. The present study is a first step toward the development of a useful tool, such as a complete set of eight different single-alien deletions, for the rapid chromosomal assignment of genes and genetic markers in A. fistulosum.

A new methodological approach to adjust alcohol exposure distributions to improve the estimation of alcohol-attributable fractions.

PubMed

Parish, William J; Aldridge, Arnie; Allaire, Benjamin; Ekwueme, Donatus U; Poehler, Diana; Guy, Gery P; Thomas, Cheryll C; Trogdon, Justin G

2017-11-01

To assess the burden of excessive alcohol use, researchers estimate alcohol-attributable fractions (AAFs) routinely. However, under-reporting in survey data can bias these estimates. We present an approach that adjusts for under-reporting in the estimation of AAFs, particularly within subgroups. This framework is a refinement of a previous method conducted by Rehm et al. We use a measurement error model to derive the 'true' alcohol distribution from a 'reported' alcohol distribution. The 'true' distribution leverages per-capita sales data to identify the distribution average and then identifies the shape of the distribution with self-reported survey data. Data are from the National Alcohol Survey (NAS), the National Household Survey on Drug Abuse (NHSDA) and the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). We compared our approach with previous approaches by estimating the AAF of female breast cancer cases. Compared with Rehm et al.'s approach, our refinement performs similarly under a gamma assumption. For example, among females aged 18-25 years, the two approaches produce estimates from NHSDA that are within a percentage point. However, relaxing the gamma assumption generally produces more conservative evidence. For example, among females aged 18-25 years, estimates from NHSDA based on the best-fitting distribution are only 19.33% of breast cancer cases, which is a much smaller proportion than the gamma-based estimates of approximately 28%. A refinement of Rehm et al.'s approach to adjusting for underreporting in the estimation of alcohol-attributable fractions provides more flexibility. This flexibility can avoid biases associated with failing to account for the underlying differences in alcohol consumption patterns across different study populations. Comparisons of our refinement with Rehm et al.'s approach show that results are similar when a gamma distribution is assumed. However, results are appreciably lower when the best-fitting distribution is chosen versus gamma-based results. © 2017 Society for the Study of Addiction.

System Engineering Analysis of Squadron Officer College

DTIC Science & Technology

2012-03-01

study identified five challenges to converting to a blended learning course. The greatest challenge is getting commitment and buy -in from senior...students thru the Army and Air Force Exchange Service (AAFES) snack bar. Managers are responsible for ensuring adequate support throughout the...Administration Function The administration function allows daily tasks to operate. SOC administration functions include providing students with

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2013 CFR

2013-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2012 CFR

2012-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2011 CFR

2011-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2010 CFR

2010-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2014 CFR

2014-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

75 FR 6688 - Section 8 Housing Assistance Payments Program-Renewal Funding Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... were published in a separate notice which can be viewed at: http://www.huduser.org/portal/datasets/aaf... be available electronically from the HUD data information page at http://www.huduser.org/portal... overview and in the FMR documentation at http://www.HUDUSER.org . In this publication, the rent and utility...

FY10 Defense Environmental Programs Annual Report to Congress

DTIC Science & Technology

2011-07-01

7,412- 2019  AIR FORCE ALPENA COUNTY REGIONAL AIRPORT / MI557282890300 17 2 $6,363 $0 $862 $1,9462012 2018  FORMERLY USED DEFENSE SITES ASH FIELD...Through FY10 ($000) IRP MMRPMMRPIRP Michigan ALPENA AAF / MI59799F231100 $001 $23 ALPENA NGTR / MI59799F228900 $610 $0 ANN ARBOR NGTR / MI59799F228800

Albanian-NATO Relations in the Fight Against International Terrorism

DTIC Science & Technology

2012-12-01

conformity with international standards.258 “The law provides for the coordination among all state institutions, bank sector , insurance companies...5 US-Adriatic Charter-5 AAF Albanian Armed Forces ACT Allied Command of Transformation AII Adriatic-Ionian Initiative AIS ...reform. With the country’s membership in PfP, Albania initiated military and defense- sector reforms in accordance with the program. In 1997

Enhancing Security and Stability in Afghanistan

DTIC Science & Technology

2015-12-01

developing Afghan institutional capacity to enhance security and stability across Afghanistan. During the June 1 through November 30, 2015, reporting...aerial fires. Nonetheless, the AAF will require coalition support for several years in order to build institutional functions and continue development...during this reporting period have been positive steps towards institutional change within the ministries. After a government-wide overhaul of the

AFCOMS (Air Force Commissary Service): Does this SOA Need an Executive Development Program?

DTIC Science & Technology

1985-03-01

ll)NALHuKAU U STADARS 19,l liii I0 󈧽 AAfR WAR COLLG RESEARCH REPORT LZ? e lNo. AU-AWC-35-011 - N4 AFCOMS: DOES THIS SQA NEED AN EXECUTIVE cm...high incidence of safety and physical security violations. Serious deficiencies existed in the financial management area. Accounting errors were not

Baseline Suitability Analysis

DTIC Science & Technology

2013-07-18

VA) • DFAS • Human Resources - HR Shared Services (Indianapolis, IN) • Personnel Security - HR Shared Services (Indianapolis, IN) DHRA...Security (Camp Lejeune) No Yes Yes AAFES Human Resources No No No Force Protection Yes Yes Yes DFAS Human Resources - HR Shared Services No...No No Personnel Security - HR Shared Services Yes Yes Yes DLA Human Resources No No Yes Personnel Security Yes Yes Yes DoDEA Human

77 FR 51894 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... RWY 20, Orig-A Baton Rouge, LA, Baton Rouge Metropolitan, Ryan Field, ILS OR LOC RWY 22R, Amdt 11 Baton Rouge, LA, Baton Rouge Metropolitan, Ryan Field, RNAV (GPS) RWY 4L, Amdt 2 Baton Rouge, LA, Baton... Fort Huachuca/Sierra Vista, AZ, Sierra Vista Muni/Libby AAF, RADAR 1, Amdt 5, CANCELLED [FR Doc. 2012...

Identification and Characterization of a Gene Cluster Mediating Enteroaggregative Escherichia Coli Aggregative Adherence Fimbria I Biogenesis

DTIC Science & Technology

1994-08-01

microscopy were performed by standard methods with fluoresceinated forward and reverse pUC primers (ABI) with a JOEL JEM 1200 EX 11 transr-ission...MyfB 11 enzrocolinca 41 220 uous plasmid regions required for AAF/I expre:sion and AA. PapD E. cobi 34 200 In this paper. we present a detailed analysis

Impact of the telephone assistive device (TAD) on stuttering severity while speaking on the telephone.

PubMed

Chambers, Nola

2009-01-01

There is extensive experimental evidence that altered auditory feedback (AAF) can have a clinically significant effect on the severity of speech symptoms in people who stutter. However, there is less evidence regarding whether these experimental effects can be observed in naturalistic everyday settings particularly when using the telephone. This study aimed to investigate the effectiveness of the Telephone Assistive Device (TAD), which is designed to provide AAF on the telephone to people who stutter, on reducing stuttering severity. Nine adults participated in a quasi-experimental study. Stuttering severity was measured first without and then with the device in participants' naturalistic settings while making and receiving telephone calls (immediate benefit). Participants were then allowed a week of repeated use of the device following which all measurements were repeated (delayed benefit). Overall, results revealed significant immediate benefits from the TAD in all call conditions. Delayed benefits in received and total calls were also significant. There was substantial individual variability in response to the TAD but none of the demographic or speech-related factors measured in the study were found to significantly impact the benefit (immediate or delayed) derived from the TAD. Results have implications for clinical decision making for adults who stutter.

Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells.

PubMed

Edenharder, R; Sager, J W; Glatt, H; Muckel, E; Platt, K L

2002-11-26

Chinese hamster lung fibroblasts, genetically engineered for the expression of rat cytochrome P450 dependent monooxygenase 1A2 and rat sulfotransferase 1C1 (V79-rCYP1A2-rSULT1C1 cells), were utilized to check for possible protective effects of beverages of plant origin, fruits, vegetables, and spices against genotoxicity induced by 2-acetylaminofluorene (AAF) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Antigenotoxic activities of juices from spinach and red beets against AAF could be monitored with similar effectivity by the HPRT-mutagenicity test (IC(50)=0.64%; 2.57%) and alkaline single cell gel electrophoresis (comet assay; IC(50)=0.12%; 0.89%) which detects DNA strand breaks and abasic sites. Applying the comet assay, genotoxicity of PhIP could, however, be demonstrated only in the presence of hydroxyurea and 1-[beta-D-arabinofuranosyl]cytosine, known inhibitors of DNA repair synthesis. As expected, AAF and PhIP were unable to induce any genotoxic effects in the parent V79 cells. Genotoxic activity of PhIP was strongly reduced in a dose-related manner by green tea and red wine, by blueberries, blackberries, red grapes, kiwi, watermelon, parsley, and spinach, while two brands of beer, coffee, black tea, rooibos tea, morellos, black-currants, plums, red beets, broccoli (raw and cooked), and chives were somewhat less active. One brand of beer was only moderately active while white wine, bananas, white grapes, and strawberries were inactive. Similarly, genotoxicity of AAF was strongly reduced by green, black, and rooibos tea, red wine, morellos, black-currants, kiwi, watermelon, and spinach while plums, red beets, and broccoli (raw) were less potent. Broccoli cooked exerted only moderate and white wine weak antigenotoxic activity. With respect to the possible mechanism(s) of inhibition of genotoxicity, benzo[a]pyrene-7,8-dihydrodiol (BaP-7,8-OH) and N-OH-PhIP were applied as substrates for the CYP1A family and for rSULT 1C1, respectively. Morellos, black-currants, and black tea strongly reduced the genotoxicity of BaP-7,8-OH, onions, rooibos tea, and red wine were less potent while red beets and spinach were inactive. On the other hand, red beets and spinach strongly inhibited the genotoxicity of N-OH-PhIP, rooibos tea was weakly active while all other items were inactive. These results are suggestive for enzyme inhibition as mechanism of protection by complex mixtures of plant origin. Taken together, our results demonstrate that protection by beverages, fruits, and vegetables against genotoxicity of heterocyclic aromatic amines may take place within metabolically competent mammalian cells as well as under the conditions of the Salmonella/reversion assay.

AAFES Shopping Center Environmental Assessment

DTIC Science & Technology

2009-08-01

Plan H2S Hydrogen Sulfide SO2 Sulfur Dioxide HWMP Hazardous Waste Management Plan SMW Strategic Missile Wing ICBM Intercontinental Ballistic Missile...the no-action alternative. Land Management and Use. A waiver would be needed prior to construction to change the land use designation from Open...occur under the no-action alternative. Hazardous Materials and Waste Management . No changes to hazardous materials or waste streams would occur

Coleman AAF, Germany (West). Limited Surface Observations Climatic Summary (LISOCS).

DTIC Science & Technology

1983-08-10

the provenance of the number (e.g., HSC 999999) which will appear on future OL-A standard products. -No II USAFETAC LIMITED SURFACE OBSERVATIONS...7 ,L A A L A - AAv STATION Y MONTH P_ ’C"NTAI.C FCrEu:uvCY OF OCCUPPENCE OF wEATE’ N TIZSN ~rOM HOUqLY OdSEOVATIONS RAIN FREEZING SNOW 1OF SMORE DUST

Surface Observation Climatic Summaries (SOCS) for Hood AAF, Texas

DTIC Science & Technology

1992-03-01

ASEIVILLE, PC 26001-2723 8. PERFUMING ORGANIZATION REPORT RUlKBER: USAFETAC/DS-92/275 9. SPOS(ORING/MONITORING AGENCY NANE AND ADDRESS: USAF...TX PERIOD OF RECORD: OCT 81 - SEP 91 LEST TO Tl"C: + 6 NORM,: APR HOURS: ALL WIND SPEED IN MOTS DII [CI 1 1-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39

Foreign Military Sales: A Historical Review of Argentina’s Purchases

DTIC Science & Technology

2013-03-01

Management Science, 2009. 3. Douglas M Lambert, “ Supply Chain Management Processes, Partnership, Performance”, Third Edition, 2008. 4. Sunil Chopra...Science in Logistics and Supply Chain Management Juan E. Perot, MBA LtCol, AAF March 2013 APPROVED FOR PUBLIC RELEASE; DISTRIBUTION...ago, and they manage various purchasing activities in each year for several systems. Therefore a particular and specific Supply Chain

40 CFR 86.1113-87 - Calculation and payment of penalty.

Code of Federal Regulations, 2010 CFR

2010-07-01

... reflect actual year-end usage of NCPs and a corrected AAF will be used to establish NCPs in future years...-1=Fraction of engines or vehicles of a subclass using NCPs in previous year (year i-1). Ai=Usage adjustment factor in year i: Ai=0.10 for i=2; Ai=0.08 for i<2. Ii=Percentage increase in overall consumer...

Special Inspector General for Afghanistan Reconstruction (SIGAR). Supplement

DTIC Science & Technology

2015-01-30

Some information concerning corps-level ANSF personnel strength data, future requirements for Afghan Air Force (AAF) equipment, the number of trained...to press. SIGAR has published an unclassified Quarterly Report to Congress since 2008, as required by our authorizing statute. On January 30, 2015...based on the declassified materials provided. Some information con- cerning corps level ANSF personnel strength data, future requirements for Afghan Air

Army and Air Force Exchange Service (AAFES): Its Relevance

DTIC Science & Technology

2011-03-24

requirements of the Master of Strategic Studies Degree. The views expressed in this student academic research paper are those of the author and do...State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...Ronda Urey Project Adviser This SRP is submitted in partial fulfillment of the requirements of the Master of Strategic Studies Degree. The

Afghanistan: Post Taliban Governance, Security, and U.S. Policy

DTIC Science & Technology

2016-09-26

billion in assistance to the ANDSF has come from these sources. There is also a NATO-Russia Council Helicopter Maintenance Trust Fund. Launched in...March 2011, this fund provides maintenance and repair capacity to the Afghan Air Force helicopter fleet, much of which is Russian-made. The Afghan...United States obligated $2.5 billion for the AAF, including nearly $1 billion for equipment and aircraft. Still, equipment, maintenance , logistical

Pursuit of the Torch: Influences on Acquisition of USAAF Fighter Aircraft Used in the North African Campaign

DTIC Science & Technology

2010-06-01

138- 143 . 36 advancing bomber versus pursuit technology took on greater significance. The need to establish a balanced force was just one more...54 Watson, 138- 143 . 55 AAF Statistical Digest: World War II, December 1945, Table 79. The percentage...72 William Wolf American Fighter-Bombers in World War II: USAAF Jabos in the MTO and ETO (Atglen, PA: Schiffer

Kitchen Appliance Upgrades Improve Water Efficiency at DOD Exchange Facilities: Best Management Practice Case Study #11: Commercial Kitchen Equipment (Brochure)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2011-09-01

The Exchange, formerly the Army and Air Force Exchange Service (AAFES), is a joint military activity and the U.S. Department of Defense?s (DOD) oldest and largest retailer. The Exchange is taking a leadership role in water efficiency improvements in their commercial kitchens by integrating water efficiency concepts into the organization?s overall sustainability plan and objectives.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fast,Jerome; Mei,Fan; Hubbe,John

Most of the instruments were deployed on the ARM Aerial Facility (AAF) Gulfstream-159 (G-1) aircraft, including those that measure atmospheric turbulence, cloud water content and drop size distributions, aerosol precursor gases, aerosol chemical composition and size distributions, and cloud condensation nuclei concentrations. Aerosol microphysical property measurements supplemented routine ARM aerosol measurements made at the surface. The G-1 completed transects over the SGP Central Facility at multiple altitudes within the boundary layer, and within and above clouds.

AAFE man-made noise experiment project. Volume 3: Appendices

NASA Technical Reports Server (NTRS)

1974-01-01

Management and operational considerations involved in the project to measure man-made electromagnetic noise at earth orbital altitudes are discussed. The subjects considered are: (1) launch and orbit of the Scout D vehicles, (2) experiment management, (3) receiver scanning considerations, (4) data handling, and (5) threshold measurements. The storage requirements for a high resolution, complete data storage library are defined. Mathematical models of signal detection probability are developed.

The radiometer transfer function for the AAFE composite two-frequency radiometer scatterometer. M.S. Thesis - Pennsylvania Univ.

NASA Technical Reports Server (NTRS)

Moore, J. H.

1973-01-01

A model was developed for the switching radiometer utilizing a continuous method of calibration. Sources of system degradation were identified and include losses and voltage standing wave ratios in front of the receiver input. After computing the three modes of operation, expressions were developed for the normalized radiometer output, the minimum detectable signal (normalized RMS temperature fluctuation), sensitivity, and accuracy correction factors).

Fritzsche AAF, Fort Ord, Salinas, California. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1972-02-17

OBSERVATIONS) 93217 FORT u-;v %.’,Ll/r i%. A s .-7 _ -_ STATION STATION MARC YEARS NORTH CLASS MOURS (L S.T.) CONITIONU PEDI MEAN (KNS) 1 -3 4 6 7 10...m .. . . . ’S - ,S: -’.. _ _ { MOM "" S USAF ETAC PSYCHROMETRIC SUMMARY AIR WEATHER SER,/XCc’/’. STATION STATION NAME YIEARS MONTH ) [PAGE 1 2100

Report on Enhancing Security and Stability in Afghanistan

DTIC Science & Technology

2015-06-01

Warrior helicopters, the AAF’s organic capability to provide aerial fires continues to grow. However, the AAF continues to struggle with a shortage ...of pilots and aircrews, as well as the maintenance of air platforms. To address the pilot shortage , coalition forces are pursuing the addition of...historically ordered supplies for the ANDSF, Afghan personnel have little experience doing it themselves. As a result, reported shortages in operational units

African-American Fathers’ Perspectives on Their Children’s Health Education: A Qualitative, Exploratory Study

PubMed Central

Odum, Mary; Smith, Matthew Lee; McKyer, E. Lisako J.

2014-01-01

Purpose: To investigate African-American fathers’ (AAF) perceptions regarding the applicability and need for their involvement as a health connection for their children and describe how participating fathers’ behavior was affected by their attitudes, knowledge, and perceptions of their influence on their children’s health. Methods: This exploratory study gathered data via semi-structured focus groups (n = 3) and thematically analyzed it utilizing a grounded theory approach. Participants included AAF (n = 20) with a mean age of 37 years (SD 11.79), with at least one child between 6 and 18 years old. Results: Four major themes were revealed: (1) appropriate health education for participants’ children (should first and foremost be delivered by parents); (2) participants’ paternal health-related guidance approach (reactive, rather than proactive); (3) participants’ perceived influences on health-related communication with their children (gender roles, efficacy constraints); and (4) paternal definitions of health (most often associated with diet). Conclusion: Understanding AAFs’ perceived and desired role in their children’s health edification can inform initiatives that actively engage these men, and nurture their level of involvement, to promote positive health behaviors among their children; this is necessary to realize their potential to actively improve the health of their children, families, and communities. PMID:25538938

Heartland Engineers: A Century of Superior Service 1907-2007

DTIC Science & Technology

2009-01-01

NJ SUPERFUND SITE, REMEDIAL DESIGN 104. INDEPENDENCE AAF: OEW LMS ASR-NOFA 105. INDEPENDENCE SATELLITE POW CAMP: PA/INPR 106. INVES. & ASSESS IMA-AR...the development of nuclear weaponry, under the Formerly Used Sites Remedial Action Plan (FUSRAP) for the Department of Energy as well as Formerly Used...further assist in the cleanup of Cold War legacy wastes through the U.S. Depart- ment of Energy’s Formerly Utilized Sites Remedial Action Program

Separate and Unequal: Race Relations in the AAF During World War 2

DTIC Science & Technology

2000-01-01

martialed the colonel. The Air Surgeon asked a consultant, Dr. Lawrence A. Kubie , who had been conducting a psychiatric study of black pilots at Selfridge...and Oscoda, to examine the colonel. Dr. Kubie went beyond his charter and made some interesting observations about racial conditions at the two...grew deeper and more charged as the war progressed. It followed that minor incidents appeared to provoke major racial disturbances. Kubie found rap

Defense Management: Better Guidance Needed in Selecting Operating Methods for Name-Brand, Fast-Food Restaurants

DTIC Science & Technology

2001-08-01

Benefit the Direct and Indirect Methods 16 Figure Figure 1: Military Exchanges’ Food Sales for Fiscal Year 1999 6 Abbreviations AAFES Army and Air Force...military installation. As the franchisee , the exchange service builds and operates the restaurants and directly employs and trains the personnel. In...they do not routinely develop a business case analysis, which would include weighing financial benefits with other factors, when determining which

75 FR 55961 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

.../1/10 LOC RWY 8, AMDT 5A. 21-Oct-10 AZ FORT HUACHUCA/ SIERRA VISTA MUNI- 0/5486 8/30/10 TAKEOFF MINIMUMS AND OBSTACLE DP, AMDT 2. SIERRA VISTA. LIBBY AAF. 21-Oct-10 LA LAKE CHARLES..... LAKE CHARLES RGNL... LOC/DME RWY 14, AMDT 8. 21-Oct-10 LA SLIDELL SLIDELL 0/7403 8/30/10 NDB RWY 36, ORIG-D. 21-Oct-10 FL...

48 CFR 253.208-2 - DD Form 448-2, Acceptance of MIPR.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 448-2, Acceptance... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.208-2 DD Form 448-2, Acceptance of MIPR. Follow the procedures at PGI 253.208-2 for use of DD Form 448-2. [71 FR 39005...

Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants.

PubMed

Vandenplas, Yvan; Mukherjee, Rajat; Dupont, Christophe; Eigenmann, Philippe; Høst, Arne; Kuitunen, Mikael; Ribes-Koninkx, Carmen; Shah, Neil; Szajewska, Hania; von Berg, Andrea; Heine, Ralf G; Zhao, Zheng-Yan

2018-05-17

The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA. Exclusively formula-fed infants aged 0-6 months presenting with symptoms suggestive of CMPA will be included in this prospective, multicentre trial which will be conducted in 10 centres in China. All infants will commence a 2-week trial of an amino acid-based formula (AAF) while eliminating all cow milk protein from their diets. After the AAF treatment period, infants will undergo an open OFC in hospital with standard cow's milk formula, followed by an open home challenge for another 2 weeks. Clinical symptoms will be documented on standardised symptom scorecards. The CoMiSS will be determined at study entry (CoMiSS 1, before the start of the AAF), after 2 weeks (CoMiSS 2, before the OFC) and after a further period of 2 weeks or when symptoms suggestive of CMPA reappear (CoMiSS 3). Weight and length will be measured at each visit. The difference between CoMiSS 1 and 2 as a predictor of the OFC outcome will also be assessed. The diagnostic accuracy of the baseline CoMiSS will be calculated. The study was approved by the Hunan Children's Hospital Medical Ethics Committee, Hunan, China. The findings of this trial will be submitted for publication in a peer-reviewed journal in paediatric nutrition or gastroenterology. Abstracts will be submitted to the relevant national and international conferences. NCT03004729; Pre-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Airpower’s Role in Homeland Defense: A Western Hemisphere Perspective

DTIC Science & Technology

2002-06-01

remain concerning airpower’s contribution to homeland defense. This thesis is neither about how to tactically solve the goalie CAP gameplan over the...Francisco to solve liaison issues between AAF units and the Navy. Aircraft were rushed to the West Coast as Lend-Lease planes were pulled off East...detect and interrogate aircraft over land out to 200 NM with a nine-hour endurance. These are usually based at Curacao, but have been pulled back since

The AAF in the Invasion of Southern France

DTIC Science & Technology

1992-01-01

action. (e) To transport and drop airborne troops engaged in the operation. (f) To cooperate with the Maquis by air action and air supply. In addition MAAF...operations in aid of the Partisans. PLANNING As far back as i April 1943 the eyes of the Allied forces in the Mediterranean were focusing on a possible landing...elimination of bush and dry vegetation fire hazards; and erection of airfield buildings. Signals The problems faced by the Signals Planning Staff at

Biggs AAF, El Paso, Texas. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1981-01-14

wet-bulb temperature depression versus dry -bulb temperature, means and standard deviations of d-j-bulb, wet-bulb (over) SDD, 1473 UNCLASS IF I ED FC...distribution tables Dry -bulb temperature versud wet-bulb temperature Cumulative percentage frequency of distribution tables 20. and dew point...PART 5 PRECIPITATION PSYCHROMETRIC.DRY VS WET BULB SNOWFALL MEAN & STO 0EV SNOW EPTH DRY BULB, WET BULB, &DEW POINtI RELATIVE HUMIDITY PARTC SURFACE

Getting Our Partners Airborne: Training Air Advisors and Their Impact In-Theater

DTIC Science & Technology

2014-06-01

perform, over time, their roles and responsi- bilities independent of US assistance. This approach is now mature in Iraq, and if the United States...Afghan airframes has begun to bear fruit . Three AAF classes have completed their pilot training in Afghanistan and, on 23 June 2013, the fourth class...launched the KA-350 program and, after it matured , transitioned operations and maintenance to full control of the IqAF. May–June 2014 Air & Space

Small Business Specialists

DTIC Science & Technology

1993-01-01

AF) Ms. Nicole A. Dillon Williams AFB AC 602/988-6618 85224-5004 Fort Huachuca HQ U.S. Army Information Systems Command (A) Mr. Michael P. Dean* ATTN...Army Medical Center (A) Maj Paul G. Michaels ATTN: HSAA-L Mr. William Brundage Presidio of San Francisco AC 415/561-5473/6289 94124-6700 SUPSHIP...Systems Division AC 408/224-7748 P. 0. Box 49028 95161-9028 San Luis Obispo National Guard (A)(AF) Col William T. Mongold USPFO for California AC 805

Single Multiplex PCR Assay To Identify Simultaneously the Six Categories of Diarrheagenic Escherichia coli Associated with Enteric Infections

PubMed Central

Vidal, Maricel; Kruger, Eileen; Durán, Claudia; Lagos, Rosanna; Levine, Myron; Prado, Valeria; Toro, Cecilia; Vidal, Roberto

2005-01-01

We designed a multiplex PCR for the detection of all categories of diarrheagenic Escherichia coli. This method proved to be specific and rapid in detecting virulence genes from Shiga toxin-producing (stx1, stx2, and eae), enteropathogenic (eae and bfp), enterotoxigenic (stII and lt), enteroinvasive (virF and ipaH), enteroaggregative (aafII), and diffuse adherent (daaE) Escherichia coli in stool samples. PMID:16208019

Doping control analysis at the Rio 2016 Olympic and Paralympic Games.

PubMed

Pereira, Henrique Marcelo Gualberto; Sardela, Vinicius Figueiredo; Padilha, Monica Costa; Mirotti, Luciana; Casilli, Alessandro; de Oliveira, Fabio Azamor; de Albuquerque Cavalcanti, Gustavo; Rodrigues, Lucas Martins Lisandro; de Araujo, Amanda Lessa Dutra; Levy, Rachel Santos; Teixeira, Pedro Antonio Castelo; de Oliveira, Felipe Alves Gomes; Duarte, Ana Carolina Giordani; Carneiro, Ana Carolina Dudenhoeffer; Evaristo, Joseph Albert Medeiros; Dos Santos, Gustavo Ramalho Cardoso; da Costa, Giovanni Carlo Verissimo; de Lima Castro, Fernando; Nogueira, Fabio Cesar Sousa; Scalco, Fernanda Bertão; Pizzatti, Luciana; de Aquino Neto, Francisco Radler

2017-11-01

This paper summarises the results obtained from the doping control analyses performed during the Summer XXXI Olympic Games (August 3-21, 2016) and the XV Paralympic Games (September 7-18, 2016). The analyses of all doping control samples were performed at the Brazilian Doping Control Laboratory (LBCD), a World Anti-Doping Agency (WADA)-accredited laboratory located in Rio de Janeiro, Brazil. A new facility at Rio de Janeiro Federal University (UFRJ) was built and fully operated by over 700 professionals, including Brazilian and international scientists, administrative staff, and volunteers. For the Olympic Games, 4913 samples were analysed. In 29 specimens, the presence of a prohibited substance was confirmed, resulting in adverse analytical findings (AAFs). For the Paralympic Games, 1687 samples were analysed, 12 of which were reported as AAFs. For both events, 82.8% of the samples were urine, and 17.2% were blood samples. In total, more than 31 000 analytical procedures were conducted. New WADA technical documents were fully implemented; consequently, state-of-the-art analytical toxicology instrumentation and strategies were applied during the Games, including different types of mass spectrometry (MS) analysers, peptide, and protein detection strategies, endogenous steroid profile measurements, and blood analysis. This enormous investment yielded one of the largest Olympic legacies in Brazil and South America. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

BUDESONIDE TREATMENT OF PROFESSIONAL ATHLETES AND ANTI-DOPING TESTING--CASE STUDIES.

PubMed

Kaliszewski, Paweł; Kończak, Danuta; Chołbiński, Piotr; Wicka, Mariola; Michalak, Dorota; Kwiatkowska, Dorota; Lewandowska-Pachecka, Sylwia; Namieśnik, Jacek; Pokrywka, Andrzej

2016-01-01

According to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established at 30 ng/mL. Additionally, the new specific regulation starting from 1 September 2014 for budesonide have been introduced that the 6β-hydroxybudesonide shall be targeted. Budesonide is a glucocorticosteroid used mainly by inhalation for asthma management. Interestingly, anti-doping laboratory statistics show that budesonide adverse analytical findings (AAF) constitute almost 50% of all reported glucocorticosteroid AAFs, even though budesonide possesses a very low systemic activity which may cause performance enhance effects. This work presents the results of five studies of controlled budesonide administration carried out on professional athletes. The samples were analyzed by using a quantitative HPLC/MS/MS method for 16α-hydroxy-prednisolone, the most abundant budesonide metabolite in urine. Our data clearly show that inhalation of budesonide at least 12 h before a competition at therapeutic doses leads to appearance of the main budesonide metabolite in concentrations exceeding prior reporting limit for this compound. Therefore, our work strongly supports recent WADA decision not to target the main budesonide metabolite using the same reporting limit as for other glucocorticosteroids.

Analysis of Airborne Radar Altimetry Measurements of the Greenland Ice Sheet

NASA Technical Reports Server (NTRS)

Ferraro, Ellen J.

1994-01-01

This dissertation presents an analysis of airborne altimetry measurements taken over the Greenland ice sheet with the 13.9 GHz Advanced Application Flight Experiment (AAFE) pulse compression radar altimeter. This Ku-band instrument was refurbished in 1990 by the Microwave Remote Sensing Laboratory at the University of Massachusetts to obtain high-resolution altitude measurements and to improve the tracking, speed, storage and display capabilities of the radar. In 1991 and 1993, the AAFE altimeter took part in the NASA Multisensor Airborne Altimetry Experiments over Greenland, along with two NASA laser altimeters. Altitude results from both experiments are presented along with comparisons to the laser altimeter and calibration passes over the Sondrestroem runway in Greenland. Although it is too early to make a conclusion about the growth or decay of the ice sheet, these results show that the instrument is capable of measuring small-scale surface changes to within 14 centimeters. In addition, results from these experiments reveal that the radar is sensitive to the different diagenetic regions of the ice sheet. Return waveforms from the wet- snow, percolation and dry-snow zones show varying effects of both surface scattering and sub-surface or volume scattering. Models of each of the diagenetic regions of Greenland are presented along with parameters such as rms surface roughness, rms surface slope and attenuation coefficient of the snow pack obtained by fitting the models to actual return waveforms.

Modelling the resource implications and budget impact of managing cow milk allergy in Australia.

PubMed

Guest, J F; Nagy, E

2009-02-01

To estimate the resource implications and budget impact of current clinical practice for managing cow milk allergy (CMA) in Australia, from the perspective of the publicly funded healthcare system. A decision model was constructed using published clinical outcomes and clinician-derived resource utilisation estimates. The model was used to estimate the expected 6-monthly levels of healthcare resource use and corresponding costs attributable to managing 6150 new CMA sufferers following referral to a specialist. The expected 6-monthly costs of managing 6150 newly-diagnosed infants with CMA following referral to a specialist was an estimated (Australian dollars, AU$) AU$6.5 million at 2006/07 prices. Clinical nutrition preparations were found to be the primary cost driver accounting for 62% of the total 6-monthly cost and clinician visits were the secondary cost driver accounting for up to a further 28% of the total 6-monthly cost. Sensitivity analysis showed there would be fewer visits to hospital-based paediatric gastroenterologists and paediatric immunologists/allergists if all newly-diagnosed patients were prescribed an amino acid formula (AAF) following referral to a specialist, instead of being managed according to current practice. CMA imposes a substantial burden on the publicly funded healthcare system in Australia. However, using an AAF as the initial treatment for CMA can potentially release limited hospital resources for alternative use within the paediatric healthcare system.

Nuclear magnetic resonance at the picomole level of a DNA adduct.

PubMed

Kautz, Roger; Wang, Poguang; Giese, Roger W

2013-10-21

We investigate the limit of detection for obtaining NMR data of a DNA adduct using modern microscale NMR instrumentation, once the adduct has been isolated at the picomole level. Eighty nanograms (130 pmol) of a DNA adduct standard, N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene 5'-monophosphate (AAF-dGMP), in 1.5 μL of D₂O with 10% methanol-d₄, in a vial, was completely picked up as a droplet suspended in a fluorocarbon liquid and loaded efficiently into a microcoil probe. This work demonstrates a practical manual method of droplet microfluidic sample loading, previously demonstrated using automated equipment, which provides a severalfold advantage over conventional flow injection. Eliminating dilution during injection and confining the sample to the observed volume produce the full theoretical mass sensitivity of a microcoil, comparable to that of a microcryo probe. With 80 ng, an NMR spectrum acquired over 40 h showed all of the resonances seen in a standard spectrum of AAF-dGMP, with a signal-to-noise ratio of at least 10, despite broadening due to previously noted effects of conformational exchange. Even with this broadening to 5 Hz, a two-dimensional total correlation spectroscopy spectrum was acquired on 1.6 μg in 18 h. This work helps to define the utility of NMR in combination with other analytical methods for the structural characterization of a small amount of a DNA adduct.

Cortico-Cortical Connectivity Within Ferret Auditory Cortex.

PubMed

Bizley, Jennifer K; Bajo, Victoria M; Nodal, Fernando R; King, Andrew J

2015-10-15

Despite numerous studies of auditory cortical processing in the ferret (Mustela putorius), very little is known about the connections between the different regions of the auditory cortex that have been characterized cytoarchitectonically and physiologically. We examined the distribution of retrograde and anterograde labeling after injecting tracers into one or more regions of ferret auditory cortex. Injections of different tracers at frequency-matched locations in the core areas, the primary auditory cortex (A1) and anterior auditory field (AAF), of the same animal revealed the presence of reciprocal connections with overlapping projections to and from discrete regions within the posterior pseudosylvian and suprasylvian fields (PPF and PSF), suggesting that these connections are frequency specific. In contrast, projections from the primary areas to the anterior dorsal field (ADF) on the anterior ectosylvian gyrus were scattered and non-overlapping, consistent with the non-tonotopic organization of this field. The relative strength of the projections originating in each of the primary fields differed, with A1 predominantly targeting the posterior bank fields PPF and PSF, which in turn project to the ventral posterior field, whereas AAF projects more heavily to the ADF, which then projects to the anteroventral field and the pseudosylvian sulcal cortex. These findings suggest that parallel anterior and posterior processing networks may exist, although the connections between different areas often overlap and interactions were present at all levels. © 2015 Wiley Periodicals, Inc.

Mackall AAF, North Carolina Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1985-03-01

0-14.5 10L A mU’ovs tD -> S.’t -f14 *I 40 ,~ 7CEILING VERSUS VISIBILI PERCENTAGE FREQUENCY OF OCCURRENCE ,FROM HOURLY OBSERVATIONS 1 _ : l .i, - L...6 7-B1 9.10 11.1213- 11lIS. 1617.18 19-20721.22 23.2425.26 27.26129-301 *3D D.B.W.B.D, BAlb W.YB. 4bD .. P+- / / -L I I... . . .. . EI. X .x. . b

AAFE large deployable antenna development program: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

The large deployable antenna development program sponsored by the Advanced Applications Flight Experiments of the Langley Research Center is summarized. Projected user requirements for large diameter deployable reflector antennas were reviewed. Trade-off studies for the selection of a design concept for 10-meter diameter reflectors were made. A hoop/column concept was selected as the baseline concept. Parametric data are presented for 15-meter, 30-meter, and 100-meter diameters. A 1.82-meter diameter engineering model which demonstrated the feasiblity of the concept is described.

USAFETAC Online Climatology: Dial-In Service Users Manual

DTIC Science & Technology

1994-02-01

89.57 U 155 724455 KIRKSVILLE REGIONAL MO 40.06 N 92.33 w 156 746710 FORT CAMPBELL (AAF) KY 36.40 N 87.30 W 158 723407 JONESBORO MUNICIPAL AR 35.50 N...In services, available to any agency of the U.S. Government, are provided upon validation of a support assistance request submitted in accordance with...users need help with Dial-In, they can get it by using the two- way message system. USAFETAC services are not limited to the software currently

Final Environmental Assessment: Addressing An Army and Air Force Exchange Service (AAFES) Lifestyle Center at Eglin Air Force Base, Florida

DTIC Science & Technology

2008-11-01

the proposed site has the potential for adverse effects on surface water bodies in the event of a spill or uncontrolled erosion. Implementation of...inclusion of a No Action Alternative against which potential effects can be compared. While the No Action Alternative would not satisfy the purpose... potential effects on project site and adjacent land uses. The foremost factor affecting a proposed action in terms of land use is its compliance

Baumholder AAF, Saarbrucken, Germany Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1972-02-07

powsht, 44 r UAIA PlOCESSING DZYVflfON EXTREME VALUES Ali ZA H*I$I sgIWtcf/1AC SAUNQUI df*kHYAAE- -- - &#A -- FROM DILtY OWV𔃺C STAMiN STAWIN NMYAR... CElLING I .--.- 4- -t------ > 1 - 2.1.1 4. . 12.4 12. . -;6Mxx: 0tl~l 3038 12. 32o2 32, 3122 12p; W2] 32;2 32,2 -.2 32 i2. ,-80 __no l. .1 ,,l ,8 I

A Short History of the Air University, Maxwell AFB, and the 42nd Air Base Wing

DTIC Science & Technology

2013-07-31

Aircraft and Engine Repair Depot No. 3 at the former Wright flying field. The depot operations continued until early 1919. In 1921, the 22nd (later...Forces (AAF) announced the opening of a specialized four- engine pilot school, initially to train air crews for the B-24 Liberator and, later, for the...systems engineering in March 2007, followed three months later by ACSC’s offering an on-line graduate degree. On 2 Mar 2009, the CCAF initiated the

A Short History of The Air University, Maxwell AFB, and the 42nd Air Base Wing

DTIC Science & Technology

2014-07-31

established Aircraft and Engine Repair Depot No. 3 at the former Wright flying field. The depot operations continued until early 1919. In 1921, the...1943 the Army Air Forces (AAF) announced the opening of a specialized four- engine pilot school, initially to train air crews for the B-24 Liberator...AFIT first offered a master’s degree in systems engineering in March 2007, followed three months later by ACSC’s offering an on-line graduate

Bridge Busters: The 397th Bombardment Group (Medium) and the B-26 Marauder in World War II

DTIC Science & Technology

2015-06-01

up largely of new pilots from the training pipeline, these established groups transitioned from flying other aircraft. Unfortunately, four fatal...The 322 BG became the first of four initial B-26 groups to join the Eighth AF’s Third Bombardment Wing. With its first aircraft arriving in England...AF refused the suggestion. Marauders continued in the medium bombing role.101 In October 1943, the AAF transferred all four B-26 groups in

Air Intelligence and the Search for the Center of Gravity

DTIC Science & Technology

1988-04-01

co inAIR INTELLIGENCE AND THE 0) ~ SEARCH FOR THE CENTER OF GRAVITY F LT COL CHARLES N. CULBERTSON 1988 - .- ,------.--.- Non VL AIR UNIVERSITY RLlo...During the 1930’s the future air commanders in the Air Corps’ primary doctrinal think tank, The Air Corps Tactical School, at Maxwell Field, took this...conversation with Speer after the war General Ira Eaker, the former commander of the 6th Air Force (8 AF was the AAF’s primary strategic striking arm in

Blacks in the Army Air Forces during World War II: The Problem of Race Relations

DTIC Science & Technology

1977-01-06

of the Southeast - ern Air Corps Training Center at Maxwell Field, to which Tuskegee was attactied, proceeded with the AAF plan. Black pilots were to...was the most unfavorable. Only in oil capacity did it rank second.5 Daily inconveniences at God- man were that the terrain was unsuitable for night...bombers that struck such objec- Activated on 1 Jul 1947. tives as oil refineries, factories, Equipped with P-47’s. hnacti- airfields, and marshalling

Alternative aircraft anti-icing formulations with reduced aquatic toxicity and biochemical oxygen demand

USGS Publications Warehouse

Gold, Harris; Joback, Kevin; Geis, Steven; Bowman, George; Mericas, Dean; Corsi, Steven R.; Ferguson, Lee

2010-01-01

The current research was conducted to identify alternative aircraft and pavement deicer and anti-icer formulations with improved environmental characteristics compared to currently used commercial products (2007). The environmental characteristics of primary concern are the biochemical oxygen demand (BOD) and aquatic toxicity of the fully formulated products. Except when the distinction among products is necessary for clarity, “deicer” will refer to aircraft-deicing fluids (ADFs), aircraft anti-icing fluids (AAFs), and pavementdeicing materials (PDMs).

The SAC Mentality: The Origins of Strategic Air Command’s Organizational Culture, 1948-51

DTIC Science & Technology

2015-04-01

following World War II left SAC in a dire predicament as it faced shortages in several critical areas. In May 1946, the AAF autho- rized the command...convictions. McMullen believed in cross-training crew members and assigning them to multiple billets to compensate for manpower short- ages. The constant...atomic outfit from the Pacific theater. According to LeMay, they cleaned the supply warehouses , stocked the parts and supplies the unit needed, and

Cortico‐cortical connectivity within ferret auditory cortex

PubMed Central

Bajo, Victoria M.; Nodal, Fernando R.; King, Andrew J.

2015-01-01

ABSTRACT Despite numerous studies of auditory cortical processing in the ferret (Mustela putorius), very little is known about the connections between the different regions of the auditory cortex that have been characterized cytoarchitectonically and physiologically. We examined the distribution of retrograde and anterograde labeling after injecting tracers into one or more regions of ferret auditory cortex. Injections of different tracers at frequency‐matched locations in the core areas, the primary auditory cortex (A1) and anterior auditory field (AAF), of the same animal revealed the presence of reciprocal connections with overlapping projections to and from discrete regions within the posterior pseudosylvian and suprasylvian fields (PPF and PSF), suggesting that these connections are frequency specific. In contrast, projections from the primary areas to the anterior dorsal field (ADF) on the anterior ectosylvian gyrus were scattered and non‐overlapping, consistent with the non‐tonotopic organization of this field. The relative strength of the projections originating in each of the primary fields differed, with A1 predominantly targeting the posterior bank fields PPF and PSF, which in turn project to the ventral posterior field, whereas AAF projects more heavily to the ADF, which then projects to the anteroventral field and the pseudosylvian sulcal cortex. These findings suggest that parallel anterior and posterior processing networks may exist, although the connections between different areas often overlap and interactions were present at all levels. J. Comp. Neurol. 523:2187–2210, 2015. © 2015 Wiley Periodicals, Inc. PMID:25845831

Bone Age Assessment of Children using a Digital Hand Atlas

PubMed Central

Gertych, Arkadiusz; Zhang, Aifeng; Sayre, James; Pospiech-Kurkowska, Sylwia; Huang, H.K

2007-01-01

We have developed an automated method to assess bone age of children using a digital hand atlas. The hand Atlas consists of two components. The first component is a database which is comprised of a collection of 1,400 digitized left hand radiographs from evenly distributed normally developed children of Caucasian (CA), Asian (AS), African-American (AA) and Hispanic (HI) origin, male (M) and female (F), ranged from 1 to 18 year old; and relevant patient demographic data along with pediatric radiologists' readings of each radiograph. This data is separate into eight categories: CAM, CAF, AAM, AAF, HIM, HIF, ASM, and ASF. In addition, CAM, AAM, HIM, and ASM are combined as one male category; and CAF, AAF, HIF, and ASF are combined as one female category. The male and female are further combined as the F & M category. The second component is a computer-assisted diagnosis (CAD) module to assess a child bone age based on the collected data. The CAD method is derived from features extracted from seven regions of interest (ROIs): the carpal bone ROI, and six phanlangeal PROIs. The PROIs are six areas including the distal and middle regions of three middle fingers. These features were used to train the eleven category fuzzy classifiers: one for each race and gender, one for the female, one male, and one F & M, to assess the bone age of a child. The digital hand atlas is being integrated with a PACS for validation of clinical use. PMID:17387000

Limited Surface Observations Climatic Summary (LISOCS), Bo Baker AAF, Germany.

DTIC Science & Technology

1987-11-01

MSC 0109711 N 47 46 1011 36 ELEV 2350 FT EDOT PARTS 1 - 5 HOURS SUMMARIZED: 0600 - 2100 LST PERIOD 01 RECORD : HOURLY OBSERVATIONS; NOv 76 - OCT 86...LIMITED SURFACE OS.RATIONS CLINAIIC SUNMAIES--LISOCS ASkVILLL NC 20501 HOURLY gSCKVauIOMSs ALL RECORD O4 RECORD SPECIaL OBSERVaTIONS RECORDED ON TPE...MEIWA STATIONS i|SININS IN JAN 19081 AND SYNOPTIC WEPORTING STATIONS RECORDED ON TH4E AN$ F0DAS 10110A AND TRARSMI 1ED LONGLINE ONLY TE HIGHEST ORDEP OF

The AAF in Northwest Africa. An Account of the Twelfth Air Force in the Northwest African Landing and the Battle for Tunisia

DTIC Science & Technology

1992-01-01

29 echelon of XII Fighter Command; the Moroccan Composite Wing operated in Morocco . All wings were activated 26 January 1943. XII Fighter Command’s...satellites, would raise Allied morale, and would encourage those ele - ments in the Axis-occupied countries which were working as best they could toward...news of the invasion, in order to fore- stall an Allied breaching of the southern coast of France, to establish submarine and air bases , and to control

Treatability Study in Support of Intrinsic Remediation for the AAFES service Station Site 56. MacDill AFB, Tampa, Florida

DTIC Science & Technology

1996-10-01

12) + 6(1) = 78 gm Oxygen 7.5(32) = 240 gm Mass Ratio of Oxygen to Benzene = 240/78 = 3.08:1 Therefore, in the absence of microbial cell production ...3.08 mg of oxygen are required to completely metabolize 1 mg of benzene. Similar calculations can be completed for toluene (3.13 mg oxygen to 1 mg... oxygen is required to mineralize 1 mg of benzene. Similar calculations can be made for toluene, ethylbenzene, and the xylenes. Based on these

Army Air Force Exchange Service Service (AAFES) Station Tyndall Air Force Base, Florida Final Tiered Environmental Assessment

DTIC Science & Technology

2010-04-20

Unts orl!i_gh t operations : t ~cr£_fore._l]~_i mpact~ to airspau: usc and management. Noise Increased noi se from construct ion and de mol it ion...DEP Northwest District Branch Office in Panama City confirms that a storm water managemen t system and storm water environmental resource permit...il ities and to construc t one bu ildi ng (7,320 square feet) to replace these old and inadequate fac iliti es. The new fac ili ty would include a

Mitchells Over the Pacific: The Dynamics of B-25 Innovation

DTIC Science & Technology

2013-06-01

began modifying the B- 25 to increase its self -defense capability. The B-25B was the version employed by the Army Air Forces (AAF) during its first...guns in the nose, waist, and floor along with a .50-caliber machine gun in the tail.31 Internally, the B-25A added armor for the aircrew and self ...Forces in World War II, vol. 1, 439. 50 Doyle, B-25 Mitchell, 10. 19 within the aircraft with a 160-gallon rubber fuel bag and ten five-gallon fuel

Surface Observation Climatic Summaries (SOCS) for Hanau AAF, Germany

DTIC Science & Technology

1992-03-01

COVER CEILING VS VISIDILITY--POP (PNDN HOURLY 038)....................... D-2-1 S"Y CUME--POP (P1FRO DOURLY 018)................................. .. D-3...PART. SPECIFIED PHENOMENA VS WIND DIRECTION--PERCENT OCCURRENCE FREQUENCY. THESE TABLES INCLUDE SUMHARY OF MONTH FOR ALL HORS AIM YEAR COMBINED. WIND...TOTAL FISCIP PRCIP FISCIP PCWIP &/OR sym &/OR 093? 1NO. or EauE SAND TO VS ORB JW .0 13.9 .S 5.4 19.9 35.9 3.2 56.9 3140 mU .1 6.9 a.0 16.9 27.1 16.3

Airplanes, Combat and Maintenance Crews, and Air Bases. The World War II and Early Cold War Architectural Legacy of Holloman Air Force Base (ca. 1942-1962)

DTIC Science & Technology

1998-11-01

to develop and build an atomic bomb. The project was under the direction of physicist J. Robert Oppenheimer , a former student at the Los Alamos Ranch...of AAF Facilities (1942- 1943 ) 39 Victory in Sight and the Atomic Age: Consolidation and Disposition of Facilities ( 1943 - 1945 ) 42 Cold War ( 1945 ...Sight and the Atomic Age ( 1943 - 1945 ) 61 Cold War Inception (July 1945 -January 1953) 63 Nuclear Escalation (January 1953-November 1963) 72 Detente

Preliminary Draft Environmental Impact Statement. Electronic Combat Test Capability, Utah Test and Training Range

DTIC Science & Technology

1989-07-01

operations beginning in 1996 . Until that time, staging will be conducted from Hill AFB and Michael AAF. ES-26 HE wF-lr 7,rr)~f~)~ ~ D 0t- 0 0 4J 444(U 44’ -P...constructed over a period of years (1990- 1996 ). Where possible, the network will follow existing or proposed new roads to minimize ground disturbance...attendant roads, power lines, and fiber optics between 1991 and 1996 . 4. Construction of a gapfiller radar in 1992. 5. Construction of TTA range

Simulation-based planning for theater air warfare

NASA Astrophysics Data System (ADS)

Popken, Douglas A.; Cox, Louis A., Jr.

2004-08-01

Planning for Theatre Air Warfare can be represented as a hierarchy of decisions. At the top level, surviving airframes must be assigned to roles (e.g., Air Defense, Counter Air, Close Air Support, and AAF Suppression) in each time period in response to changing enemy air defense capabilities, remaining targets, and roles of opposing aircraft. At the middle level, aircraft are allocated to specific targets to support their assigned roles. At the lowest level, routing and engagement decisions are made for individual missions. The decisions at each level form a set of time-sequenced Courses of Action taken by opposing forces. This paper introduces a set of simulation-based optimization heuristics operating within this planning hierarchy to optimize allocations of aircraft. The algorithms estimate distributions for stochastic outcomes of the pairs of Red/Blue decisions. Rather than using traditional stochastic dynamic programming to determine optimal strategies, we use an innovative combination of heuristics, simulation-optimization, and mathematical programming. Blue decisions are guided by a stochastic hill-climbing search algorithm while Red decisions are found by optimizing over a continuous representation of the decision space. Stochastic outcomes are then provided by fast, Lanchester-type attrition simulations. This paper summarizes preliminary results from top and middle level models.

Metagenomics reveals flavour metabolic network of cereal vinegar microbiota.

PubMed

Wu, Lin-Huan; Lu, Zhen-Ming; Zhang, Xiao-Juan; Wang, Zong-Min; Yu, Yong-Jian; Shi, Jin-Song; Xu, Zheng-Hong

2017-04-01

Multispecies microbial community formed through centuries of repeated batch acetic acid fermentation (AAF) is crucial for the flavour quality of traditional vinegar produced from cereals. However, the metabolism to generate and/or formulate the essential flavours by the multispecies microbial community is hardly understood. Here we used metagenomic approach to clarify in situ metabolic network of key microbes responsible for flavour synthesis of a typical cereal vinegar, Zhenjiang aromatic vinegar, produced by solid-state fermentation. First, we identified 3 organic acids, 7 amino acids, and 20 volatiles as dominant vinegar metabolites. Second, we revealed taxonomic and functional composition of the microbiota by metagenomic shotgun sequencing. A total of 86 201 predicted protein-coding genes from 35 phyla (951 genera) were involved in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of Metabolism (42.3%), Genetic Information Processing (28.3%), and Environmental Information Processing (10.1%). Furthermore, a metabolic network for substrate breakdown and dominant flavour formation in vinegar microbiota was constructed, and microbial distribution discrepancy in different metabolic pathways was charted. This study helps elucidating different metabolic roles of microbes during flavour formation in vinegar microbiota. Copyright © 2016 Elsevier Ltd. All rights reserved.

Alcohol and Homicide in Russia and the United States: A Comparative Analysis*

PubMed Central

Landberg, Jonas; Norström, Thor

2011-01-01

Objective: The object of this study was to perform a comparative analysis of the aggregate relationship between alcohol and homicide in Russia and in the United States. The comparison was based on the magnitude of the alcohol effect, the alcohol attributable fraction (AAF), and the degree to which total consumption could account for trends in homicide. Method: We analyzed total and sex-specific homicide rates for the age groups 15–64 years, 15–34 years, and 35–64 years. The study period was 1959–1998 for Russia and 1950–2002 for the United States. For the United States, alcohol consumption was gauged by sales of alcohol; for Russia, estimated unrecorded consumption was included as well. The data were analyzed through autoregressive integrated moving average (ARIMA) modeling. Results: The results show that, for Russia as well as for the United States, a 1 -L increase in consumption was associated with an increase in homicides of about 10%, although the absolute effect was markedly larger in Russia because of differences in homicide rates. The AAF estimates suggested that 73% and 57% of the homicides would be attributable to alcohol in Russia and in the United States, respectively. Most of the temporal variation in the Russian homicide rate could be accounted for by the trend in drinking, whereas the U.S. trend in total alcohol consumption had a more limited ability to predict the trend in homicides. Conclusions: We conclude that the role of alcohol in homicide seems to be larger in Russia than in the United States. PMID:21906499

Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.

PubMed

Takahashi, Kuniyuki; Hishida, Ryuichi; Kubota, Yamato; Kudoh, Masaharu; Takahashi, Sugata; Shibuki, Katsuei

2006-03-01

Functional brain imaging using endogenous fluorescence of mitochondrial flavoprotein is useful for investigating mouse cortical activities via the intact skull, which is thin and sufficiently transparent in mice. We applied this method to investigate auditory cortical plasticity regulated by acoustic environments. Normal mice of the C57BL/6 strain, reared in various acoustic environments for at least 4 weeks after birth, were anaesthetized with urethane (1.7 g/kg, i.p.). Auditory cortical images of endogenous green fluorescence in blue light were recorded by a cooled CCD camera via the intact skull. Cortical responses elicited by tonal stimuli (5, 10 and 20 kHz) exhibited mirror-symmetrical tonotopic maps in the primary auditory cortex (AI) and anterior auditory field (AAF). Depression of auditory cortical responses regarding response duration was observed in sound-deprived mice compared with naïve mice reared in a normal acoustic environment. When mice were exposed to an environmental tonal stimulus at 10 kHz for more than 4 weeks after birth, the cortical responses were potentiated in a frequency-specific manner in respect to peak amplitude of the responses in AI, but not for the size of the responsive areas. Changes in AAF were less clear than those in AI. To determine the modified synapses by acoustic environments, neural responses in cortical slices were investigated with endogenous fluorescence imaging. The vertical thickness of responsive areas after supragranular electrical stimulation was significantly reduced in the slices obtained from sound-deprived mice. These results suggest that acoustic environments regulate the development of vertical intracortical circuits in the mouse auditory cortex.

Resolution of R-(-) and S-(+)- enantiomers of clenbuterol in pharmaceutical preparations and black-market products using liquid chromatography-tandem mass spectrometry.

PubMed

Velasco-Bejarano, Benjamín; Bautista, Jahir; Noguez, Ma Olivia; Camacho, Evangelina; Rodríguez, Martha E; Rodríguez, Leonardo

2017-11-01

Several banned substances are illegally used by athletes in racemic mixtures for performance enhancement. These include clenbuterol, methyl hexaneamine, methamphetamines, and amphetamines. Clenbuterol is present in a large number of doping samples from Olympic and non-Olympic athletes that have adverse analytical findings (AAFs). In some cases, the presence of these substances could be the result of consumption of meat contaminated with clenbuterol. In other cases, the origin is not clear. In this study, 27 products with racemic clenbuterol were evaluated using a new analytical methodology for the resolution of R-(-) and S-(+)-enantiomers of clenbuterol by liquid chromatography-tandem mass spectrometry (LC-MS/MS) using a chiral column in 15 min with good separation. The method developed can also be used for the analysis of other biological matrices such as urine, serum, and meat. The resolution between two peaks' (R s ) value obtained using chromatographic data was 1.03. Both clenbuterol enantiomers were present in all products analyzed and the ratio was nearly 1. The origin of the product was not important for determining the presence of one or both enantiomers. All products displayed a 50:50 ratio of clenbuterol enantiomers. To the best of our knowledge, clenbuterol ratio determination of a large number of pharmaceutical preparations and black-market products has not been reported previously. The information shown could be used by national anti-doping organizations and the athletes with AAFs attributed to clenbuterol. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Microfinance, wage employment and housework: a gender analysis.

PubMed

Khan, M R

1999-08-01

This paper examines the loan-use pattern of women involved in wage employment and their benefits from such loans in Bangladesh. The effects of wage employment on gender relations and how these women balance loan use, wage employment, and housework were also explored. The study was conducted among women enrolled in the Ayesha Abed Foundation (AAF) of the Bangladesh Rural Advancement Committee (BRAC) in Jamalpur district, central Bangladesh. The AAF was established to generate employment and income for poor rural women. Data were gathered through survey, interviews, and focus-group discussions. Findings revealed that women wage earners avail themselves of the BRAC loans for consumption, asset accumulation, land purchase, and other productive purposes. About 53% of their loans were used by others and only 34 out of 341 women in the sample actually used the loans themselves. The loans were repaid by sewing or subsistence work, mainly in the subcenters (52%), through income from rickshaw pulling by their husbands (24%), and by selling vegetables, eggs, or milk. Furthermore, findings showed that the household work of women wage earners is generally taken up by other women in the family and has resulted in more men taking part in household responsibilities. In conclusion, wage employment plays an important factor in the promotion of the economic and social empowerment of women. Economic empowerment is observed in the greater degree of control women have over the money they earn. Social empowerment is manifested in the expanding mobility of women, whereby they are able to interact with other women and generate support systems.

Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation.

PubMed

Lucarelli, Sandra; Di Nardo, Giovanni; Lastrucci, Ginevra; D'Alfonso, Ylenia; Marcheggiano, Adriana; Federici, Tatiana; Frediani, Simone; Frediani, Tullio; Cucchiara, Salvatore

2011-07-16

Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula We have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy. Prick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants. These data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.

Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set.

PubMed

Yamagata, Tetsuo; Zanelli, Ugo; Gallemann, Dieter; Perrin, Dominique; Dolgos, Hugues; Petersson, Carl

2017-09-01

1. We compared direct scaling, regression model equation and the so-called "Poulin et al." methods to scale clearance (CL) from in vitro intrinsic clearance (CL int ) measured in human hepatocytes using two sets of compounds. One reference set comprised of 20 compounds with known elimination pathways and one external evaluation set based on 17 compounds development in Merck (MS). 2. A 90% prospective confidence interval was calculated using the reference set. This interval was found relevant for the regression equation method. The three outliers identified were justified on the basis of their elimination mechanism. 3. The direct scaling method showed a systematic underestimation of clearance in both the reference and evaluation sets. The "Poulin et al." and the regression equation methods showed no obvious bias in either the reference or evaluation sets. 4. The regression model equation was slightly superior to the "Poulin et al." method in the reference set and showed a better absolute average fold error (AAFE) of value 1.3 compared to 1.6. A larger difference was observed in the evaluation set were the regression method and "Poulin et al." resulted in an AAFE of 1.7 and 2.6, respectively (removing the three compounds with known issues mentioned above). A similar pattern was observed for the correlation coefficient. Based on these data we suggest the regression equation method combined with a prospective confidence interval as the first choice for the extrapolation of human in vivo hepatic metabolic clearance from in vitro systems.

Acceptability of Family Violence: Underlying Ties Between Intimate Partner Violence and Child Abuse.

PubMed

Gracia, Enrique; Rodriguez, Christina M; Martín-Fernández, Manuel; Lila, Marisol

2017-05-01

Intimate partner violence (IPV) and child abuse (CA) are two forms of family violence with shared qualities and risk factors, and are forms of violence that tend to overlap. Acceptability of violence in partner relationships is a known risk factor in IPV just as acceptability of parent-child aggression is a risk factor in CA. We hypothesized that these acceptability attitudes may be linked and represent the expression of a general, underlying nonspecific acceptance of violence in close family relationships. The sample involved 164 male IPV offenders participating in a batterer intervention program. Implicit measures, which assess constructs covertly to minimize response distortions, were administered to assess acceptability of partner violence against women and acceptability of parent-child aggression. To determine whether acceptability attitudes regarding both forms of violence were related to a higher order construct tapping general acceptance of family violence, Bayesian confirmatory factor analyses were conducted. Findings supported a hierarchical (bifactor) model with a general factor expressing a nonspecific acceptance of family violence, and two specific factors reflecting acceptability of violence in intimate partner and parent-child relationships, respectively. This hierarchical model supporting a general acceptance of violence in close family relationships can inform future research aiming to better understand the connections between IPV and CA.

76 FR 9757 - Information Collection; Submission for OMB Review, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... information collection request (ICR) consisting of four instruments entitled Request to Transfer a Segal Education Award Amount Form, Accept/Decline Award Transfer Form, Request to Revoke Transfer of Education Award Form, and Rescind Acceptance of Award Transfer Form for review and approval in accordance with the...

Regulatory perspectives on acceptability testing of dosage forms in children.

PubMed

Kozarewicz, Piotr

2014-08-05

Current knowledge about the age-appropriateness of different dosage forms is still fragmented or limited. Applicants are asked to demonstrate that the target age group(s) can manage the dosage form or propose an alternative strategy. However, questions remain about how far the applicant must go and what percentage of patients must find the strategy 'acceptable'. The aim of this overview is to provide an update on current thinking and understanding of the problem, and discuss issues relating to the acceptability testing. This overview should be considered as means to start a wider discussion which hopefully will result in a harmonised, globally acceptable approach for confirmation of the acceptability in the future. Copyright © 2014 Elsevier B.V. All rights reserved.

Flight Investigation to Improve the Dynamic Longitudinal Stability and Control-Feel Characteristics of the P-63A-1 Airplane (AAF No. 42-68889) with Closely Balanced Experimental Elevators

NASA Technical Reports Server (NTRS)

Johnson, Harold I.

1946-01-01

Results of flight tests of a control-feel aid presented. This device consisted of a spring and dashpot connected in series between the control stick and airplane structure. The device was tested in combination with an experimental elevator and bobweight which had given unsatisfactory dynamic stability and control-feel characteristics in previous tests. The control-feel aid effected marked improvement in both the control-feel characteristics and the control-feel dynamic longitudinal stability of the airplane.

Camp Page AAF, Chunchon, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1974-03-06

112 .@ . . . t. j : td LI4.,’ ~ _ _ I _ ’, "l. A9,’ 4. 3. A lLt2S 54/ 53 1~ 1.1 . 21 1.31 1 . 1~ 5!1 _____ {ŗ 4 14 11 50, 49 2 . 1. , 1 .9 .𔃻 .1...DEPRESSION (F) TOTAL TOTAL (F) 0 - 1-2 3 -4 5-6 78- 9 10 it 2 13.14 15.16󈧕 I8’ 9 21.-2123.24 5-2627- 28129 30 31 D.B. W.. Dy b.1bW t BbD - P,- 14

Officer Candidates Education and Training in the Albanian Armed Forces

DTIC Science & Technology

2008-12-12

16-03-1999) 2 Note: The AAF manpower will be 14 500 ( Source: Ms Zana Xhuka Deputy Minister of Defense, “Metropol” Newspaper, Tirana 26/04/2007...Shtesa në pension vetëm për pjesën e mbetur pas miratimit të ligjit” Interviste me Zëvendësministren e Mbrojtjes Zj. Zana Xhuka 25 “Shtesa në pension...vetëm për pjesën e mbetur pas miratimit të ligjit” Interviste me Zëvendësministren e Mbrojtjes Zj. Zana Xhuka 59 26 Les Brownlee and Peter J

Measurement of Flying Qualities of a Dehavilland Mosquito F-8 Airplane (AAF No. 43-334960) I: Lateral and Directional Stability and Control Characteristics

NASA Technical Reports Server (NTRS)

Gray, W.E.; Talmage, D.B.; Crane, H.L.

1945-01-01

The data presented have no bearing on performance characteristics of airplane, which were considered exceptionally good in previous tests. Some of the undesirable features of lateral and directional stability and control characteristics of the F-8 are listed. Directional stability, with rudder fixed, did not sufficiently restrict aileron yaw; rudder control was inadequate during take-off and landing, and was insufficient to fly airplane with one engine; in clean condition, power of ailerons was slightly below minimum value specified; it was difficult to trim airplane in rough air.

Hiedelberg AAF, Germany Revised Uniform Summary of Surface Weather Observations (RUSSWO) Parts A-F.

DTIC Science & Technology

1981-10-05

P’EE’i 10 Z6 -5 -4 Z - -2v -->2 - . I -l ’A --. 1. 5/16 0 NO CELIN -- 14.9 16.6 17.1 19.8 20*0 21.1 21.3 21.7 22.5 22.5 22.5 22.6 22.7 22.7 22.8 >_000...99.7100.0 00.0100.0100.0 00.000.0 cOo 0o. TOTAL NUMBER OF OBSERVATIONS 9 USAF "TAC ,W 64 0-14-5 (OL A) P.e .OU.. DION OF VNI FON ANN.. ...... . -r4 -A V

Vibrationally Excited Ions: Quenching Reaction Enhancement, Lifetimes

DTIC Science & Technology

1991-01-01

affinities in our lad- A,.=Af exp( - AS/IR) = I .IX 10𔄃 cm’ S_ with limits der . Any change it. P.A.(Br), ither due to a change in bet~een 7.Sx l3 9and...8217K P Huber and G Hereberg. C oeto of Drateooc Molecules ( Van "M Tubs’, G JasAay. N D Toeddy. and B. B. Fergusn. Ini J Mass Nostrand-Reinhold. New York...objectives and it seemed possible .aat neut - rals such as N,. Xe and CF, might provide suitable monitor gases for vibra- tionally excited HBr*. For HBr

Archival of aircraft scatterometer data from AAFE RADSCAT missions

NASA Technical Reports Server (NTRS)

Schroeder, L. C.; Mitchell, J. L.

1983-01-01

Aircraft scatterometer data obtained over the ocean with the Radiometer-Scatterometer (RADSCAT) instrument is documented. The normalized radar cross section data was obtained at 13.9 GHz for a variety of ocean surface wind conditions, which are also presented. All such valid RADSCAT ocean scatterometer data for which surface truth was obtained are included, except for ice research missions during the last year of RADSCAT's lifetime. Aircraft scatterometer data obtained for the SEASAT underflights were with a second instrument, the Airborne Microwave Scatterometer (AMSCAT). The RADSCAT data are archived on card image computer tapes and on microfiche.

A survey of caregivers of Nigerian children less than 6 years of age to determine the experience and perception of acceptability of oral solid dosage forms.

PubMed

Orubu, Samuel; Okwelogu, Chinyere; Opanuga, Olabisi; Tuleu, Catherine

2018-02-05

The World Health Organization (WHO) recommends flexible solid oral dosage forms such as dispersible tablet as the preferred formulation for (young) children, especially in developing/low- and middle-income countries, LMIC. The aim of this study was to assess experience, perceptions of acceptability, and formulation preferences, among 10 oral dosage forms for young children in a sample of end-users in Nigeria as an exemplar LMIC. Using a semi-structured and validated questionnaire, 148 caregivers were surveyed. Acceptability was assessed by level of liking using a 3-point Likert scale and ease of administration. Preference was assessed from participants' dosage form of choice. Oral dosage forms assessed were those mentioned in the British National Formulary for children, 2013. The formulation perceived as the most acceptable was the chewable/suckable tablet. However, preference was for liquids. Specifically with the dispersible tablet, whilst 89% (n=111) of caregivers of young children found it easy-to-administer, only 50% of children liked it. There is a gap between the proposal of dispersible tablet as the preferred dosage form for young children and caregivers' perceptions of acceptability and preference. Educational strategies to increase acceptability of dispersible tablets as the preferred formulation for young children would be required. Copyright © 2017 Elsevier B.V. All rights reserved.

Knowledge About Sounds—Context-Specific Meaning Differently Activates Cortical Hemispheres, Auditory Cortical Fields, and Layers in House Mice

PubMed Central

Geissler, Diana B.; Schmidt, H. Sabine; Ehret, Günter

2016-01-01

Activation of the auditory cortex (AC) by a given sound pattern is plastic, depending, in largely unknown ways, on the physiological state and the behavioral context of the receiving animal and on the receiver's experience with the sounds. Such plasticity can be inferred when house mouse mothers respond maternally to pup ultrasounds right after parturition and naïve females have to learn to respond. Here we use c-FOS immunocytochemistry to quantify highly activated neurons in the AC fields and layers of seven groups of mothers and naïve females who have different knowledge about and are differently motivated to respond to acoustic models of pup ultrasounds of different behavioral significance. Profiles of FOS-positive cells in the AC primary fields (AI, AAF), the ultrasonic field (UF), the secondary field (AII), and the dorsoposterior field (DP) suggest that activation reflects in AI, AAF, and UF the integration of sound properties with animal state-dependent factors, in the higher-order field AII the news value of a given sound in the behavioral context, and in the higher-order field DP the level of maternal motivation and, by left-hemisphere activation advantage, the recognition of the meaning of sounds in the given context. Anesthesia reduced activation in all fields, especially in cortical layers 2/3. Thus, plasticity in the AC is field-specific preparing different output of AC fields in the process of perception, recognition and responding to communication sounds. Further, the activation profiles of the auditory cortical fields suggest the differentiation between brains hormonally primed to know (mothers) and brains which acquired knowledge via implicit learning (naïve females). In this way, auditory cortical activation discriminates between instinctive (mothers) and learned (naïve females) cognition. PMID:27013959

Effect of human umbilical cord blood stem cell transplantation on oval cell response in 2-AAF/CCL4 liver injury model: experimental immunohistochemical study.

PubMed

Abdellatif, Hussein; Shiha, Gamal; Saleh, Dalia M; Eltahry, Huda; Botros, Kamal G

2017-01-01

Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe liver injury. We detected the effect of hUCB stem cell transplantation on natural response of oval cells to injury. Twenty-four female albino rats were randomly divided into three groups: (A) control, (B) liver injury with hepatocyte block, and (C) hUCB transplanted group. Hepatocyte block was performed by administration of 2-acetylaminofluorene (2-AAF) for 12 days. CCL4 was administrated at day 5 from experiment start. Animals were sacrificed at 9 days post CCL4 administration, and samples were collected for biochemical and histopathological analysis. Oval cell response to injury was evaluated by the percentage of oval cells in the liver tissue and frequency of cells incorporated into new ducts. Immunohistochemical analysis of oval cell response to injury was performed. There was significant deviation in the hUCB-transplanted (4.9 ± 1.4) and liver injury groups (2.4 ± 0.9) as compared to control (0.89 ± 0.4) 9 days post injury. Detection of oval cell response was dependant on OV-6 immunoreactivity. For mere localization of cells with human origin, CD34 antihuman immunoreactivity was performed. There was no significant difference in endogenous OV-6 immunoreactivity following stem cell transplantation as compared to the liver injury group. In vivo transplantation of cord blood stem cells (hUCB) does not interfere with natural oval cell response to liver injury.

Stuttering in adults: the acoustic startle response, temperamental traits, and biological factors.

PubMed

Alm, Per A; Risberg, Jarl

2007-01-01

The purpose of this study was to investigate the relation between stuttering and a range of variables of possible relevance, with the main focus on neuromuscular reactivity, and anxiety. The explorative analysis also included temperament, biochemical variables, heredity, preonset lesions, and altered auditory feedback (AAF). An increased level of neuromuscular reactivity in stuttering adults has previously been reported by [Guitar, B. (2003). Acoustic startle responses and temperament in individuals who stutter. Journal of Speech Language and Hearing Research, 46, 233-240], also indicating a link to anxiety and temperament. The present study included a large number of variables in order to enable analysis of subgroups and relations between variables. Totally 32 stuttering adults were compared with nonstuttering controls. The acoustic startle eyeblink response was used as a measure of neuromuscular reactivity. No significant group difference was found regarding startle, and startle was not significantly correlated with trait anxiety, stuttering severity, or AAF. Startle was mainly related to calcium and prolactin. The stuttering group had significantly higher scores for anxiety and childhood ADHD. Two subgroups of stuttering were found, with high versus low traits of childhood ADHD, characterized by indications of preonset lesions versus heredity for stuttering. The study does not support the view that excessive reactivity is a typical characteristic of stuttering. The increased anxiety is suggested to mainly be an effect of experiences of stuttering. As a result of reading this article, the reader will be able to: (a) critically discuss the literature regarding stuttering in relation to acoustic startle, anxiety, and temperament; (b) describe the effect of calcium on neuromuscular reactivity; (c) discuss findings supporting the importance of early neurological incidents in some cases of stuttering, and the relation between such incidents and traits of ADHD or ADD; and (d) discuss the role of genetics in stuttering.

Chicken Fetal Liver DNA Damage and Adduct Formation by Activation-Dependent DNA-Reactive Carcinogens and Related Compounds of Several Structural Classes

PubMed Central

Williams, Gary M.; Duan, Jian-Dong; Brunnemann, Klaus D.; Iatropoulos, Michael J.; Vock, Esther; Deschl, Ulrich

2014-01-01

The chicken egg genotoxicity assay (CEGA), which utilizes the liver of an intact and aseptic embryo-fetal test organism, was evaluated using four activation-dependent DNA-reactive carcinogens and four structurally related less potent carcinogens or non-carcinogens. In the assay, three daily doses of test substances were administered to eggs containing 9–11-day-old fetuses and the fetal livers were assessed for two endpoints, DNA breaks using the alkaline single cell gel electrophoresis (comet) assay and DNA adducts using the 32P-nucleotide postlabeling (NPL) assay. The effects of four carcinogens of different structures requiring distinct pathways of bioactivation, i.e., 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (B[a]P), and diethylnitrosamine (DEN), were compared with structurally related non-carcinogens fluorene (FLU) and benzo[e]pyrene (B[e]P) or weak carcinogens, aflatoxin B2 (AFB2) and N-nitrosodiethanolamine (NDELA). The four carcinogens all produced DNA breaks at microgram or low milligram total doses, whereas less potent carcinogens and non-carcinogens yielded borderline or negative results, respectively, at higher doses. AAF and B[a]P produced DNA adducts, whereas none was found with the related comparators FLU or B[e]P, consistent with comet results. DEN and NDELA were also negative for adducts, as expected in the case of DEN for an alkylating agent in the standard NPL assay. Also, AFB1 and AFB2 were negative in NPL, as expected, due to the nature of ring opened aflatoxin adducts, which are resistant to enzymatic digestion. Thus, the CEGA, using comet and NPL, is capable of detection of the genotoxicity of diverse DNA-reactive carcinogens, while not yielding false positives for non-carcinogens. PMID:24973097

Comparison of Retracking Algorithms Using Airborne Radar and Laser Altimeter Measurements of the Greenland Ice Sheet

NASA Technical Reports Server (NTRS)

Ferraro, Ellen J.; Swift, Calvin T.

1995-01-01

This paper compares four continental ice sheet radar altimeter retracking algorithms using airborne radar and laser altimeter data taken over the Greenland ice sheet in 1991. The refurbished Advanced Application Flight Experiment (AAFE) airborne radar altimeter has a large range window and stores the entire return waveform during flight. Once the return waveforms are retracked, or post-processed to obtain the most accurate altitude measurement possible, they are compared with the high-precision Airborne Oceanographic Lidar (AOL) altimeter measurements. The AAFE waveforms show evidence of varying degrees of both surface and volume scattering from different regions of the Greenland ice sheet. The AOL laser altimeter, however, obtains a return only from the surface of the ice sheet. Retracking altimeter waveforms with a surface scattering model results in a good correlation with the laser measurements in the wet and dry-snow zones, but in the percolation region of the ice sheet, the deviation between the two data sets is large due to the effects of subsurface and volume scattering. The Martin et al model results in a lower bias than the surface scattering model, but still shows an increase in the noise level in the percolation zone. Using an Offset Center of Gravity algorithm to retrack altimeter waveforms results in measurements that are only slightly affected by subsurface and volume scattering and, despite a higher bias, this algorithm works well in all regions of the ice sheet. A cubic spline provides retracked altitudes that agree with AOL measurements over all regions of Greenland. This method is not sensitive to changes in the scattering mechanisms of the ice sheet and it has the lowest noise level and bias of all the retracking methods presented.

Ice-type classifications from airborne pulse-limited radar altimeter return waveform characteristics

NASA Technical Reports Server (NTRS)

Fedor, L. S.; Hayne, G. S.; Walsh, E. J.

1989-01-01

During mid-March 1978, the NASA C-130 aircraft was deployed to Eielson Air Force Base in Fairbanks, Alaska, to make a series of flights over ice in the Beaufort Sea. The radar altimeter data analyzed were obtained northeast of Mackenzie Bay on March 14th in the vicinity of 69.9 deg N, 134.2 deg W. The data were obtained with a 13.9 GHz radar altimeter developed under the NASA Advanced Applications Flight Experiments (AAFE) Program. This airborne radar was built as a forerunner of the Seasat radar altimeter, and utilized the same pulse compression technique. Pulse-limited radar data taken with the altimeter from 1500-m altitude over sea ice are registered to high-quality photography. The backscattered power is statistically related the surface conductivity and to the number of facets whose surface normal is directed towards the radar. The variations of the radar return waveform shape and signal level are correlated with the variation of the ice type determined from photography. The AAFE altimeter has demonstrated that the return waveform shape and signal level of an airborne pulse-limited altimeter at 13.9 GHz respond to sea ice type. The signal level responded dramatically to even a very small fracture in the ice, as long as it occurred directly at the altimeter nadir point. Shear zones and regions of significant compression ridging consistently produced low signal levels. The return waveforms frequently evidenced the characteristics of both specular and diffuse scattering, and there was an indication that the power backscattered at 3 deg off-nadir in a shear zone was actually somewhat higher than that from nadir.

Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency.

PubMed

Tsuda, Hiroko; Tokunaga, Fuminori; Nagamitsu, Hiroshi; Koide, Takehiko

2006-01-01

Misfolded and unassembled glycoproteins are eliminated from the endoplasmic reticulum (ER) lumen by the ER-associated degradation (ERAD). We previously identified a Tyr595Cys (Y595C) mutation of protein S (PS) in a family of a quantitative PS deficiency. The mutation causes intracellular degradation and decreased secretion of the Y595C mutant PS. The aim of the present study was to further characterize the molecular basis of the intracellular degradation of the mutant. We stably expressed the mutant in mammalian cells, and analyzed the intracellular localization of the protein. The intracellular degradation pathway was determined by pulse-chase analyses in the presence of various inhibitors of ERAD. Endoglycosidase H digestion and immunofluorescence staining revealed the mutant being retained in the ER. Epoxomicin, a potent and specific proteasome inhibitor, and Ala-Ala-Phe-CH(2)Cl (AAF), an inhibitor of tripeptidyl peptidase II (TPPII), suppressed the intracellular degradation of the mutant by about 65% and 50%, respectively. When epoxomicin was combined with AAF, the inhibitory effect was substantially enhanced. Although castanospermine, an inhibitor of glucosidases I and II, did not affect the degradation, kifunensine, an inhibitor of ER mannosidase I, suppressed it. Thus, it appears that the Y595C mutant is degraded through more than one pathway of ERAD, including the proteasome-dependent pathway and an alternate proteasome-independent pathway where proteases such as TPPII may be involved. Production of the critical B isoform of Man(8)GlcNAc(2) targets the mutant for ERAD, however, the interaction with calnexin/calreticulin through monoglucosylated oligosaccharides may not be required for the degradation of the mutant.

Divergent host preferences of above- and below-ground Culex pipiens mosquitoes and their hybrid offspring.

PubMed

Fritz, M L; Walker, E D; Miller, J R; Severson, D W; Dworkin, I

2015-06-01

Culex pipiens form pipiens and Cx. pipiens form molestus (Diptera: Culicidae) belong to a cosmopolitan taxonomic group known as the Pipiens Assemblage. Hybridization between these forms is thought to contribute to human transmission of West Nile virus (WNV) in North America. Complementary choice and no-choice landing assays were developed to examine host acceptance by North American Cx. pipiens in the laboratory. Populations collected from above- and below-ground sites in suburban Chicago were identified as forms pipiens and molestus using a polymerase chain reaction-based assay. Avian and human host acceptance was then quantified for the two populations, as well as for their hybrid and backcross offspring. No-choice tests were used to demonstrate that both the pipiens and molestus forms were capable of feeding on human and avian hosts. Choice tests were used to demonstrate that form pipiens females were strongly avian-seeking; an individual's probability of accepting the chick host was 85%. Form molestus females were more likely to accept the human host (87%). Rates of host acceptance by F1 and backcross progeny were intermediate to those of their parents. The results suggest that host preferences in Cx. pipiens are genetically determined, and that ongoing hybridization between above- and below-ground populations is an important contributor to epizootic transmission of WNV in North America. © 2015 The Royal Entomological Society.

Ansbach AAF, Katterback, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1974-10-29

jAUG 100,C lQoo 99.8 98,1 90,0 8)92 66,1 47,0 23.7 7605 176 ( SEP 100.0 100 9C 100,0 9903 95.1 84q9 72,6 54 331,1 79.9 020 OCT 100O 100 ’, 100.0...10’. 20’. 30% 40% 50% 60’. 70% 80% 1 90,% HUMIDITY (OBS jAUG 00ൊ "°,o 00vo 100.0 100. 100.0 100.0 96.8 9o#3 57 9 . 93! Wo65 looov 11009 1oo LI o.1

Grafenwohr AAF, Germany. Revised Uniform Summary of Surface Weather Observations. Parts A-F.

DTIC Science & Technology

1987-10-01

76.4 78.2 582 2553 1 29.7 37.8 54.4 62.3 64.7 68.2 73.7 74.2 76.4 76.4 76.6 76.9 77,6 78.2 85.5 6 E 27001 70. 5 J.2_ Sb_ O 64.4 66.9 70.6 76.3 76.8 79.1...G1 bt GF GE GE bE GL Gr 6E GE iE GE GL (E GL GE r(ET I ISO 9 86 -6 98 4L 32 29 20 16 12 lI 8 s 4 C

25 CFR 162.560 - What forms of security are acceptable under a WSR lease?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What forms of security are acceptable under a WSR lease? 162.560 Section 162.560 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Bonding and Insurance § 162.560 What forms of...

25 CFR 162.560 - What forms of security are acceptable under a WSR lease?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What forms of security are acceptable under a WSR lease? 162.560 Section 162.560 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Bonding and Insurance § 162.560 What forms of...

Secondary Waste Cast Stone Waste Form Qualification Testing Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westsik, Joseph H.; Serne, R. Jeffrey

2012-09-26

The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is being constructed to treat the 56 million gallons of radioactive waste stored in 177 underground tanks at the Hanford Site. The WTP includes a pretreatment facility to separate the wastes into high-level waste (HLW) and low-activity waste (LAW) fractions for vitrification and disposal. The LAW will be converted to glass for final disposal at the Integrated Disposal Facility (IDF). Cast Stone – a cementitious waste form, has been selected for solidification of this secondary waste stream after treatment in the ETF. The secondary-waste Cast Stone waste form must be acceptablemore » for disposal in the IDF. This secondary waste Cast Stone waste form qualification testing plan outlines the testing of the waste form and immobilization process to demonstrate that the Cast Stone waste form can comply with the disposal requirements. Specifications for the secondary-waste Cast Stone waste form have not been established. For this testing plan, Cast Stone specifications are derived from specifications for the immobilized LAW glass in the WTP contract, the waste acceptance criteria for the IDF, and the waste acceptance criteria in the IDF Permit issued by the State of Washington. This testing plan outlines the testing needed to demonstrate that the waste form can comply with these waste form specifications and acceptance criteria. The testing program must also demonstrate that the immobilization process can be controlled to consistently provide an acceptable waste form product. This testing plan also outlines the testing needed to provide the technical basis for understanding the long-term performance of the waste form in the disposal environment. These waste form performance data are needed to support performance assessment analyses of the long-term environmental impact of the secondary-waste Cast Stone waste form in the IDF« less

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children's Acceptability of Oral Formulations (CALF) Study.

PubMed

Ranmal, Sejal R; Cram, Anne; Tuleu, Catherine

2016-11-30

A lack of evidence to guide the design of age-appropriate and acceptable dosage forms has been a longstanding knowledge gap in paediatric formulation development. The Children's Acceptability of Oral Formulations (CALF) study captured end-user perceptions and practices with a focus on solid oral dosage forms, namely tablets, capsules, chewables, orodispersibles, multiparticulates (administered with food) and mini-tablets (administered directly into the mouth). A rigorous development and testing phase produced age-adapted questionnaires as measurement tools with strong evidence of validity and reliability. Overall, 590 school children and adolescents, and 428 adult caregivers were surveyed across hospitals and various community settings. Attitudes towards dosage forms primarily differed based on age and prior use. Positive attitudes to tablets and capsules increased with age until around 14 years. Preference was seen for chewable and orodispersible preparations across ages, while multiparticulates were seemingly less favourable. Overall, 59.6% of school children reported willingness to take 10mm diameter tablets, although only 32.1% of caregivers perceived this size to be suitable. While not to be taken as prescriptive guidance, the results of this study provide some evidence towards rational dosage form design, as well as methodological approaches to help design tools for further evaluation of acceptability within paediatric studies. Copyright © 2016 Elsevier B.V. All rights reserved.

AAFE RADSCAT data reduction programs user's guide

NASA Technical Reports Server (NTRS)

Claassen, J. P.

1976-01-01

Theory, design and operation of the computer programs which automate the reduction of joint radiometer and scatterometer observations are presented. The programs reduce scatterometer measurements to the normalized scattering coefficient; whereas the radiometer measurements are converted into antenna temperatures. The programs are both investigator and user oriented. Supplementary parameters are provided to aid in the interpretation of the observations. A hierarchy of diagnostics is available to evaluate the operation of the instrument, the conduct of the experiments and the quality of the records. General descriptions of the programs and their data products are also presented. This document therefore serves as a user's guide to the programs and is therefore intended to serve both the experimenter and the program operator.

Fort Knox/Godman AAF, Kentucky Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1985-03-01

255-504 OVER 50 ASU’ O 1 S, .. . .- -- -2..... . 2 2 ABLE 0 S MEAN GREATEST LEAST S¢ NOWo ~l NONE TR AC E I i 2 i .4 I 2 66 2 VR10 A TS - 21C 3 4.6 7 12...ls ; P- . I - i r,--- 41a A.’g) i-u u At L 33.4 56.3 5P.9 1 L1.J1 1.11 61.161.1 61.1 61.1 61 1 I I.1f 61.11 1. 1 ! 61.11 61.1’ B )0r 347 - 6 Di 63. 65

Hunter AAF, Savannah, Georgia. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1970-11-18

Center of AIT/I.1Q-11 No Chile 13 Ft. to F~po 62 Rnwy 6 mar 62 Located 471 pt. 883 of Ros. No Chgc No Chile 15 Ft. to Feb 67 7 Mar 67 1. Located 300 Ft...N of lbwy 09 No Chile No Chile 25 Ft. o Feb 68 at 500 Ft Marker. 2. Located 300 Ft. N of Rawy 27 No Chile 15 Ft. at 500 Ft. Marker. 8 Mar 68 1...Located 500 Ft.from. Center Linc No Chile No Chile 20 Ft. May 70 and 1500 Pt from end of 1"w 95 2. Located 1100 Ft from Center Lir No Chge J-- 16 Ft and

Limited Surface Observations Climatic Summary (LISOCS) Bad Kreuznach AAF Germany.

DTIC Science & Technology

1988-02-01

GE GE GE GE GE GE FEET I IsO 90 80 61 48 𔃾 32 24 2G 16 12 10 8 5 4 0 NO CEIL 1 33.9 35.1 37.4 40.1 40.1 4n.1 40.4 40.4 40.4 40.4 40.4 40.4 40.4 40.4...93.3 93.3 93.3 93.3 93.3 93.3 93.3 GE 27001 68.6 75.1 88.1 94.9 96.1 96.6 97.2 97.2 97.4 97.4 97.4 97.4 97.4 97.4 97.4 GE Iei 1 68.6 75.1 88.1 94.9

AAFE man-made noise experiment project. Volume 1: Introduction experiment definition and requirements

NASA Technical Reports Server (NTRS)

1974-01-01

An experiment was conducted to measure and map the man-made radio frequency emanations which exist at earth orbital altitudes. The major objectives of the program are to develop a complete conceptual experiment and developmental hardware for the collection and processing of data required to produce meaningful statistics on man-made noise level variations as functions of time, frequency, and geographic location. A wide dispersion measurement receiver mounted in a spacecraft operating in a specialized orbit is used to obtain the data. A summary of the experiment designs goals and constraints is provided. The recommended orbit for the spacecraft is defined. The characteristics of the receiver and the antennas are analyzed.

Features and treatment modality of iliopsoas abscess and its outcome: a 6-year hospital-based study

PubMed Central

2013-01-01

Background Percutaneous drainage (PCD) and surgical intervention are two primary treatment options for iliopsoas abscess (IPA). However, there is currently no consensus on when to use PCD or surgical intervention, especially in patients with gas-forming IPA. This study compared the characteristics of patients with gas-forming and non-gas forming IPA and their mortality rates under different treatment modalities. An algorithm for selecting appropriate treatment for IPA patients is proposed based on our findings. Methods Eighty-eight IPA patients between July 2007 and February 2013 were enrolled in this retrospective study. Patients < 18 years of age or with an incomplete course of treatment were excluded. Demographic information, clinical characteristics, and outcomes of different treatment approaches were compared between gas-forming IPA and non-gas forming IPA patients. Results Among the 88 enrolled patients, 27 (31%) had gas-forming IPA and 61 (69%) had non-gas forming IPA. The overall intra-hospital mortality rate was 25%. The gas-forming IPA group had a higher intra-hospital mortality rate (12/27, 44.0%) than the non-gas forming IPA group (10/61, 16.4%) (P < 0.001). Only 2 of the 13 patients in the gas-forming IPA group initially accepting PCD had a good outcome (success rate = 15.4%). Three of the 11 IPA patients with failed initial PCD expired, and 8 of the 11 patients with failed initial PCD accepted salvage operation, of whom 5 survived. Seven of the 8 gas-forming IPA patients accepting primary surgical intervention survived (success rate = 87.5%). Only 1 of the 6 gas-forming IPA patients who accepted antibiotics alone, without PCD or surgical intervention, survived (success rate = 16.7%). In the non-gas forming IPA group, 23 of 61 patients initially accepted PCD, which was successful in 17 patients (73.9%). The success rate of PCD was much higher in the non-gas forming group than in the gas-forming group (P <0.01). Conclusions Based on the high failure rate of PCD and the high success rate of surgical intervention in our samples, we recommend early surgical intervention with appropriate antibiotic treatment for the patients with gas-forming IPA. Either PCD or primary surgical intervention is a suitable treatment for patients with non-gas forming IPA. PMID:24321123

41 CFR 304-6.1 - May we accept a monetary payment in the form of cash from a non-Federal source?

Code of Federal Regulations, 2010 CFR

2010-07-01

... payment in the form of cash from a non-Federal source? 304-6.1 Section 304-6.1 Public Contracts and Property Management Federal Travel Regulation System PAYMENT OF TRAVEL EXPENSES FROM A NON-FEDERAL SOURCE... of cash from a non-Federal source? No, you may not accept a monetary payment in the form of cash from...

Adherence and virulence genes of Escherichia coli from children diarrhoea in the Brazilian Amazon.

PubMed

Benevides-Matos, Najla; Pieri, Fabio A; Penatti, Marilene; Orlandi, Patrícia P

2015-03-01

The bacterial pathogen most commonly associated with endemic forms of childhood diarrhoea is Escherichia coli . Studies of epidemiological characteristics of HEp-2 cell-adherent E. coli in diarrhoeal disease are required, particularly in developing countries. The aim of this study was evaluate the presence and significance of adherent Escherichia coli from diarrhoeal disease in children. The prevalence of LA, AA, and DA adherence patterns were determined in HEp-2 cells, the presence of virulence genes and the presence of the O serogroups in samples obtained from 470 children with acute diarrhoea and 407 controls in Porto Velho, Rondônia, Brazil. E. coli isolates were identified by PCR specific for groups of adherent E. coli . Out of 1,156 isolates obtained, 128 (11.0%) were positive for eae genes corresponding to EPEC, however only 38 (29.6%) of these amplified bfpA gene . EAEC were isolated from 164 (14.1%) samples; of those 41(25%), 32 (19%) and 16 (9.7%) amplified eagg , aggA or aafA genes, respectively and aggA was significantly associated with diarrhoea ( P = 0.00006). DAEC identified by their adhesion pattern and there were few isolates. In conclusion, EAEC was the main cause of diarrhoea in children, especially when the aggA gene was present, followed by EPEC and with a negligible presence of DAEC.

ARM Aerial Facility ArcticShark Unmanned Aerial System

NASA Astrophysics Data System (ADS)

Schmid, B.; Hubbell, M.; Mei, F.; Carroll, P.; Mendoza, A.; Ireland, C.; Lewko, K.

2017-12-01

The TigerShark Block 3 XP-AR "ArcticShark" Unmanned Aerial System (UAS), developed and manufactured by Navmar Applied Sciences Corporation (NASC), is a single-prop, 60 hp rotary-engine platform with a wingspan of 6.5 m and Maximum Gross Takeoff Weight of 295 Kg. The ArcticShark is owned by the U.S. Department of Energy (DOE) and has been operated by Pacific Northwest National Laboratory (PNNL) since March 2017. The UAS will serve as an airborne atmospheric research observatory for DOE ARM, and, once fully operational, can be requested through ARM's annual call for proposals. The Arctic Shark is anticipated to measure a wide range of radiative, aerosol, and cloud properties using a variable instrument payload weighing up to 46 Kg. SATCOM-equipped, it is capable of taking measurements up to altitudes of 5.5 Km over ranges of up to 500 Km. The ArcticShark operates at airspeeds of 30 to 40 m/s, making it capable of slow sampling. With a full fuel load, its endurance exceeds 8 hours. The aircraft and its Mobile Operations Center (MOC) have been hardened specifically for operations in colder temperatures.ArcticShark's design facilitates rapid integration of various types of payloads. 2500 W of its 4000 W electrical systems is dedicated to payload servicing. It has an interior payload volume of almost 85 L and four wing-mounted pylons capable of carrying external probes. Its payload bay volume, electrical power, payload capacity, and flight characteristics enable the ArcticShark to accommodate multiple combinations of payloads in numerous configurations. Many instruments will be provided by the ARM Aerial Facility (AAF), but other organizations may eventually propose instrumentation for specific campaigns. AAF-provided measurement capabilities will include the following atmospheric state and thermodynamics: temperature, pressure, winds; gases: H2O and CO2; up- and down-welling broadband infrared and visible radiation; surface temperature; aerosol number concentration, size distribution, absorption composition (filter samples), and cloud-droplet size distribution.

An investigation of the diversity of strains of enteroaggregative Escherichia coli isolated from cases associated with a large multi-pathogen foodborne outbreak in the UK.

PubMed

Dallman, Timothy J; Chattaway, Marie A; Cowley, Lauren A; Doumith, Michel; Tewolde, Rediat; Wooldridge, David J; Underwood, Anthony; Ready, Derren; Wain, John; Foster, Kirsty; Grant, Kathie A; Jenkins, Claire

2014-01-01

Following a large outbreak of foodborne gastrointestinal (GI) disease, a multiplex PCR approach was used retrospectively to investigate faecal specimens from 88 of the 413 reported cases. Gene targets from a range of bacterial GI pathogens were detected, including Salmonella species, Shigella species and Shiga toxin-producing Escherichia coli, with the majority (75%) of faecal specimens being PCR positive for aggR associated with the Enteroaggregative E. coli (EAEC) group. The 20 isolates of EAEC recovered from the outbreak specimens exhibited a range of serotypes, the most frequent being O104:H4 and O131:H27. None of the EAEC isolates had the Shiga toxin (stx) genes. Multilocus sequence typing and single nucleotide polymorphism analysis of the core genome confirmed the diverse phylogeny of the strains. The analysis also revealed a close phylogenetic relationship between the EAEC O104:H4 strains in this outbreak and the strain of E. coli O104:H4 associated with a large outbreak of haemolytic ureamic syndrome in Germany in 2011. Further analysis of the EAEC plasmids, encoding the key enteroaggregative virulence genes, showed diversity with respect to FIB/FII type, gene content and genomic architecture. Known EAEC virulence genes, such as aggR, aat and aap, were present in all but one of the strains. A variety of fimbrial genes were observed, including genes encoding all five known fimbrial types, AAF/1 to AAF/V. The AAI operon was present in its entirety in 15 of the EAEC strains, absent in three and present, but incomplete, in two isolates. EAEC is known to be a diverse pathotype and this study demonstrates that a high level of diversity in strains recovered from cases associated with a single outbreak. Although the EAEC in this study did not carry the stx genes, this outbreak provides further evidence of the pathogenic potential of the EAEC O104:H4 serotype.

Chicken fetal liver DNA damage and adduct formation by activation-dependent DNA-reactive carcinogens and related compounds of several structural classes.

PubMed

Williams, Gary M; Duan, Jian-Dong; Brunnemann, Klaus D; Iatropoulos, Michael J; Vock, Esther; Deschl, Ulrich

2014-09-01

The chicken egg genotoxicity assay (CEGA), which utilizes the liver of an intact and aseptic embryo-fetal test organism, was evaluated using four activation-dependent DNA-reactive carcinogens and four structurally related less potent carcinogens or non-carcinogens. In the assay, three daily doses of test substances were administered to eggs containing 9-11-day-old fetuses and the fetal livers were assessed for two endpoints, DNA breaks using the alkaline single cell gel electrophoresis (comet) assay and DNA adducts using the (32)P-nucleotide postlabeling (NPL) assay. The effects of four carcinogens of different structures requiring distinct pathways of bioactivation, i.e., 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (B[a]P), and diethylnitrosamine (DEN), were compared with structurally related non-carcinogens fluorene (FLU) and benzo[e]pyrene (B[e]P) or weak carcinogens, aflatoxin B2 (AFB2) and N-nitrosodiethanolamine (NDELA). The four carcinogens all produced DNA breaks at microgram or low milligram total doses, whereas less potent carcinogens and non-carcinogens yielded borderline or negative results, respectively, at higher doses. AAF and B[a]P produced DNA adducts, whereas none was found with the related comparators FLU or B[e]P, consistent with comet results. DEN and NDELA were also negative for adducts, as expected in the case of DEN for an alkylating agent in the standard NPL assay. Also, AFB1 and AFB2 were negative in NPL, as expected, due to the nature of ring opened aflatoxin adducts, which are resistant to enzymatic digestion. Thus, the CEGA, using comet and NPL, is capable of detection of the genotoxicity of diverse DNA-reactive carcinogens, while not yielding false positives for non-carcinogens. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Isolation and characterization of a R2R3-MYB transcription factor gene related to anthocyanin biosynthesis in the spathes of Anthurium andraeanum (Hort.).

PubMed

Li, Chonghui; Qiu, Jian; Yang, Guangsui; Huang, Surong; Yin, Junmei

2016-10-01

A R2R3-MYB gene AaMYB2 was isolated from Anthurium andraeanum (Hort.) and was functionally characterized to be a positive transcriptional regulator for anthocyanin biosynthesis in the spathes and leaves. Spathe coloration is an important Anthurium andraeanum (Hort.) characteristic, which is mainly contributed by anthocyanins. R2R3-MYB transcription factors (TFs) are important regulators of anthocyanin biosynthesis in plants. Here we describe the identification and characterization of AaMYB2, a member in subgroup 6 of the R2R3-MYB TFs family, which correlated with anthocyanin biosynthesis in A. andraeanum. AaMYB2 was a nuclear-localization protein with positive transcriptional activity, and prominently expressed in the red spathes. Ectopic expression of AaMYB2 in tobacco led to anthocyanin accumulation and up-regulation of the early and late anthocyanin pathway genes, particularly NtDFR, NtANS, and NtUFGT, and the endogenous TF genes NtAn2 and NtAn1 in leaves. In the developing red spathes of 'Tropical' and 'Vitara', the expression of AaMYB2 was closely linked to anthocyanin accumulation, and co-expressed with AaCHS, AaF3H, and AaANS, the latter two of which were regarded as the potential targets of the R locus encoding a TF controlling spathe colors inheritance in anthurium. In addition, the transcription level of AaMYB2 in various cultivars with different color phenotypes showed that AaMYB2 was drastically expressed in the spathes from the red, pink, and purple cultivars, but hardly detected in the spathes from the white and green ones. Besides, AaMYB2 also showed higher expression in newly developmental leaves when anthocyanin was actively biosynthesized. Taken together, AaMYB2 positively related to anthocyanin biosynthesis in anthurium spathes and leaves, and appeared to regulate the expression of AaF3H, AaANS, and possibly AaCHS.

Solid oral forms availability in children: a cost saving investigation

PubMed Central

Lajoinie, Audrey; Henin, Emilie; Kassai, Behrouz; Terry, David

2014-01-01

Aim To assess the suitability and potential cost savings, from both the hospital and community perspective, of prescribed oral liquid medicine substitution with acceptable solid forms for children over 2 years. Method Oral liquid medicines dispensed from a paediatric hospital (UK) in 1 week were assessed by screening for existence of the solid form alternative and evaluating the acceptability of the available solid form, firstly related to the prescribed dose and secondly to acceptable size depending on the child's age. Costs were calculated based on providing treatment for 28 days or prescribed duration for short term treatments. Results Over 90% (440/476) of liquid formulations were available as a marketed solid form. Considering dosage acceptability (maximum of 10% deviation from prescribed dosage or 0% for narrow therapeutic range drugs, maximum tablet divisions into quarters) 80% of liquids could be substituted with a solid form. The main limitation for liquid substitution would be solid form size. However, two-thirds of prescribed liquids could have been substituted with a suitable solid form for dosage and size, with estimated savings being of £5K and £8K in 1 week, respectively based on hospital and community costs, corresponding to a projected annual saving of £238K and £410K (single institution). Conclusion Whilst not all children over 2 years will be able to swallow tablets, drug cost savings if oral liquid formulations were substituted with suitable solid dosage forms would be considerable. Given the numerous advantages of solid forms compared with liquids, this study may provide a theoretical basis for investing in supporting children to swallow tablets/capsules. PMID:24965935

Development of a short form of the Japanese version of the Interpersonal Relationship Inventory.

PubMed

Sumi, Katsunori

2009-10-01

The Interpersonal Relationship Inventory (Tilden, Nelson, & May, 1990a) is a 39-item self-report measure to assess three aspects (support, reciprocity, and conflict) of perceived social relationships. In this research, short forms of the Japanese version (Sumi, 2003) of the inventory were developed on the basis of data from two sources. For the item selection, data from 340 Japanese college students (148 women, 192 men; M age = 21.6 yr., SD = 1.6) who completed the original full form of the inventory were used to create three internally consistent short forms. The reliability and construct validity of the short forms were examined upon administering them to among 513 college students (226 women, 287 men; M age =19.9 yr., SD = 1.4). All the subscales of the short forms had acceptable internal consistency (alphas = .70-.90) and test-retest reliability (rs = .72-.81). Confirmatory factor analysis of each short form supported the fact that each form had a three-factor structure. Scores on the subscales shared acceptable overlapping variance with the corresponding subscale scores of the original full form, and these scores were weakly but significantly correlated with the scores for satisfaction with social support, loneliness, and perceived stress. All the short forms had acceptable reliability and construct validity.

25 CFR 162.554 - What form of monetary compensation payment is acceptable under a WSR lease?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What form of monetary compensation payment is acceptable under a WSR lease? 162.554 Section 162.554 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation...

25 CFR 162.554 - What form of monetary compensation payment is acceptable under a WSR lease?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What form of monetary compensation payment is acceptable under a WSR lease? 162.554 Section 162.554 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation...

77 FR 3278 - Agency Information Collection Activities: Form G-1145; Revision of a Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-23

... households. If an applicant or petitioner wants to be notified via email and/or text message on their cell phone that their application or petition has been accepted, they are requested to provide their email address and/or cell phone number on the E-Notification of Application/Petition Acceptance, Form G-1145...

Sucrose acceptance and different forms of associative learning of the honey bee (apis mellifera L.) in the field and laboratory.

PubMed

Mujagic, Samir; Sarkander, Jana; Erber, Barbara; Erber, Joachim

2010-01-01

The experiments analyze different forms of learning and 24-h retention in the field and in the laboratory in bees that accept sucrose with either low (/=30% or >/=50%) concentrations. In the field we studied color learning at a food site and at the hive entrance. In the laboratory olfactory conditioning of the proboscis extension response (PER) was examined. In the color learning protocol at a feeder, bees with low sucrose acceptance thresholds (/=50%). Retention after 24 h is significantly different between the two groups of bees and the choice reactions converge. Bees with low and high acceptance thresholds in the field show no differences in the sucrose sensitivity PER tests in the laboratory. Acceptance thresholds in the field are thus a more sensitive behavioral measure than PER responsiveness in the laboratory. Bees with low acceptance thresholds show significantly better acquisition and 24-h retention in olfactory learning in the laboratory compared to bees with high thresholds. In the learning protocol at the hive entrance bees learn without sucrose reward that a color cue signals an open entrance. In this experiment, bees with high sucrose acceptance thresholds showed significantly better learning and reversal learning than bees with low thresholds. These results demonstrate that sucrose acceptance thresholds affect only those forms of learning in which sucrose serves as the reward. The results also show that foraging behavior in the field is a good predictor for learning behavior in the field and in the laboratory.

Hospital materials managers need to be aware of actions that constitute legal acceptance.

PubMed

Decker, R

1990-12-01

A hospital invited bids for building materials for a hospital construction project. A supplier submitted a bid which asked the hospital to sign and return a trade association form contract. The hospital didn't return the form but used the supplier's bid as part of the general contract for the entire project and notified the supplier and the general contractor. Later, the supplier submitted a higher bid for the same material contending that the hospital hadn't accepted the first bid as they hadn't followed the instructions. The hospital materials manager feels that the bid was properly accepted. In this dialogue, Dr. Decker reviews the legal issues involved in the different ways of accepting an offer.

Gray AAF/Fort Lewis, Washington. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-12-14

each of more than 15,000 reporting stations around the world. This is the provenance of the number (e.g., HSC 999999) which will appear on future OL-A...CEILING VERSUS VISIBILITY2 .’ " ., ’LC.’ - -.SA\\H VERSUS A’ AAV /FT L5W S .f 73-! ’E GE F Q E N y OF $C’<,>1F - PO.’ -O’ L OBSER, ATON’ :j - . 2 .3 2...3ś o --:---- .. 609- - . . ; L. _ _ cL AL CLT’MAT’LOCY PRANCH L -- "TAC PSYCHROMETRIC SUMMARY A: TH7’ SERVICE/MA: 74- 7, . AAV AA /F T LEk!S kA

AAFE man-made noise experiment project. Volume 2: Project and experiment discussions

NASA Technical Reports Server (NTRS)

1974-01-01

An experiment for the acquisition and processing of man-made noise interference data on earth orbital altitudes is discussed. The objectives of the project are to confirm the results of analytical studies concerning radio frequency man-made noise in space. It is stated that the measurements of the amounts and types of noise in frequency bands of interest could allow the allocation and utilization of frequencies to be optimized and would also contribute to the engineering objective of optimizing flight receiving systems. A second objective of the project was to design and fabricate a noise measuring receiver which would demonstrate the feasibility of the experiment design under the project. The procedures for acquiring and processing the electromagnetic radiation data are discussed.

An Assessment of the Scholarship of Teaching and Learning in Public Administration from 2009-2013

ERIC Educational Resources Information Center

Stuteville, Rebekkah; Click, Eric

2016-01-01

The acceptance of the Scholarship of Teaching and Learning (SoTL) as a legitimate form of scholarly investigation and the shape that it takes in post-secondary education are inherently discipline-specific. This paper examines how the character and heritage of public administration influence the acceptance of SoTL, and the form that it takes. It…

Multi-EMR Structured Data Entry Form: User-Acceptance Testing of a Prototype.

PubMed

Zavar, Abbas; Keshavjee, Karim

2017-01-01

Capturing standardized data from multiple EMRs at the point of care is highly desirable for a variety of uses, including quality improvement programs, multi-centered clinical trials and clinical decision support. In this paper, we describe the design, development and user acceptance testing of a prototype web-based form (the Form) that can integrate with multiple EMRs. We used the validated UTAUT questionnaire to assess the likelihood of uptake of the Form into clinical practice. The Form was found to be easy to use, elicits low anxiety, supports productivity and is perceived to have good support. Users would benefit from training and from better social signaling about the importance of using the Form in their practice. Making the Form more fun and interesting could help increase uptake.

Construct and Predictive Validity of Social Acceptability: Scores From High School Teacher Ratings on the School Intervention Rating Form

ERIC Educational Resources Information Center

Harrison, Judith R.; State, Talida M.; Evans, Steven W.; Schamberg, Terah

2016-01-01

The purpose of this study was to evaluate the construct and predictive validity of scores on a measure of social acceptability of class-wide and individual student intervention, the School Intervention Rating Form (SIRF), with high school teachers. Utilizing scores from 158 teachers, exploratory factor analysis revealed a three-factor (i.e.,…

Genres Across Cultures: Types of Acceptability Variation

ERIC Educational Resources Information Center

Shaw, Philip; Gillaerts, Paul; Jacobs, Everett; Palermo, Ofelia; Shinohara, Midori; Verckens, J. Piet

2004-01-01

One can ask four questions about genre validity across cultures. Does a certain form or configuration occur in the culture in question? Is it acceptable? If acceptable, is it in practice preferred? Is it recommended by prescriptive authorities? This paper reports the results of an attempt to answer these questions empirically by testing the…

N′-[(E)-3-Chloro-2-fluoro­benzyl­idene]-6-methyl­nicotinohydrazide monohydrate

PubMed Central

Fun, Hoong-Kun; Quah, Ching Kheng; Shyma, P. C.; Kalluraya, Balakrishna; Vidyashree, J. H. S.

2012-01-01

The title compound, C14H11ClFN3O·H2O, exists in an E conformation with respect to the N=C bond. The pyridine ring forms a dihedral angle of 5.00 (9)° with the benzene ring. In the crystal, the ketone O atom accepts one O—H⋯O and one C—H⋯O hydrogen bond, the water O atom accepts one N—H⋯O and two C—H⋯O hydrogen bonds and the pyridine N atom accepts one O—H⋯N hydrogen bond, forming layers parallel to the ab plane. PMID:22798798

Nutrition and food technology for a Controlled Ecological Life Support System (CELSS)

NASA Technical Reports Server (NTRS)

Glaser, P. E.; Mabel, J. A.

1981-01-01

Food technology requirements and a nutritional strategy for a Controlled Ecological Life Support System (CELSS) to provide adequate food in an acceptable form in future space missions are discussed. The establishment of nutritional requirements, dietary goals, and a food service system to deliver acceptable foods in a safe and healthy form and the development of research goals and priorities were the main objectives of the study.

Data Obtained in the Flight Measurements to Determine the Stability and Control Characteristics of a C-54D Airplane (AAF No. 42-72713) and a Summary of the Test Program

NASA Technical Reports Server (NTRS)

Talmage, Donald B.; Reeder, John P.

1947-01-01

The flight investigation of the C-54D airplane was initiated to determine the necessity of changes or additions to existing handling-qualities requirements to cove the case of instrument approaches with large airplanes. This paper gives a brief synopsis of the results and presents the measured data of tests to determine the stability and control characteristics. It was found that no new requirements were necessary to cover the problems of instrument approaches. The C-54D airplane tested met the Amy and Navy stability and control requirements except for the following items. The control-system friction with autopilot installed vas double that allowed by the requirements. The amount of friction was found to impair the controllability of the airplane in precision flying. The lateral and directional characteristics were good except that the maximum pb/2V was slightly below the minimum required, and the elevator-control forces to obtain the maximum pb/2V at low speeds were above the Army and Navy requirements. The longitudinal stability and control characteristics were good except that the elevator-control forces exceeded the limits of the Army and Navy requirements in turns and in landings. The stalling characteristics were considered good in all conditions with the stall warning in the form of tail buffeting occurring at speeds approximately 5 miles per hour above the stall.

Treatment of Pediatric Obsessive Compulsive Disorder Utilizing Parent-Facilitated Acceptance and Commitment Therapy

ERIC Educational Resources Information Center

Barney, Jennifer Y.; Field, Clint E.; Morrison, Kate L.; Twohig, Michael P.

2017-01-01

Acceptance and commitment therapy (ACT) is a modern form of cognitive behavior therapy that uses acceptance and mindfulness-based procedures to address clinical issues. A brief protocol of ACT was used with 3 children ages 10 and 11 years who were diagnosed with obsessive compulsive disorder (OCD). Results showed notable and clinically significant…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giangrande, Scott E.; Feng, Zhe; Jensen, Michael P.

Routine cloud, precipitation and thermodynamic observations collected by the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) and Aerial Facility (AAF) during the 2-year US Department of Energy (DOE) ARM Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign are summarized. These observations quantify the diurnal to large-scale thermodynamic regime controls on the clouds and precipitation over the undersampled, climatically important Amazon basin region. The extended ground deployment of cloud-profiling instrumentation enabled a unique look at multiple cloud regimes at high temporal and vertical resolution. This longer-term ground deployment, coupled with two short-term aircraft intensive observing periods, allowed new opportunitiesmore » to better characterize cloud and thermodynamic observational constraints as well as cloud radiative impacts for modeling efforts within typical Amazon wet and dry seasons.« less

Michales AAF, Dugway, Utah. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A - F

DTIC Science & Technology

1974-03-21

We, Boi Do. o 90/ 89 . -- -- - -A lt eI -- ... .. -- .- -"a___ ..... J __v a L_:I 4 4.56/ 81 Io 1 31 . I- ,5"z l .2 6 26 ,_. __ll5 , , ._. .3 1 2...30 31 D.B./W.B. v),, 00,16W., d.16s Des Porn , " ,.b/ 15 I _..- -i7 12/1- - - r- - - t . .... -9 1 6 I’ TOTAL . 2. . . . ... .... -55 1. .9 .2 .1...3. 4f . { . 14. 1015 1S~6 17 - 18119.- 20 21,-22123.2- 2 8 9 30 j1D.B.’W.B. Dry Bulb] Wt 6u.b6[5-a Porn ’ 60/ 59 - Iti!I I-./’ ’ ’ ’ ’ t- - " 5 1

History of the Field Artillery School. Volume 2. World War II

DTIC Science & Technology

1946-10-31

1; FAR TC (B)- I AR MD- I 161 All successful candidates rA-9; INF-11 MC - I, transferred~to Class No. TD -1l; ARMD-. AAF-4; 162. FAPTC M-).4; FA1RTC...FT T brT fUf1 71 -- 4T 4 G Lbug, 8~ 65 2W 1 3 -1"- IT-4P I ’l- -Y -- 44 1f 3c 52 T8 r TOT- 42 ’a- G 2 7 MT~ U’r, Td ~ 41 r - 50 DI 1 41 v 3 4 2...or any other pertinent remarks) lFnlstPd Experience: bei Ia _ ___ -,T- 1tI rh U_ OF ate WIN__ IRS, Admln.ML Unit Grade ___ Dais Map flat Td ftsI Ud

Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterise their environmental risk and hazard.

PubMed

Mendoza, A; Aceña, J; Pérez, S; López de Alda, M; Barceló, D; Gil, A; Valcárcel, Y

2015-07-01

This work analyses the presence of twenty-five pharmaceutical compounds belonging to seven different therapeutic groups and one iodinated contrast media (ICM) in a Spanish medium-size hospital located in the Valencia Region. Analysis of the target compounds in the hospital wastewater was performed by means of solid phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry analysis (HPLC-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on Predicted No Effect Concentration (PNEC) was also applied to estimate Hazard Quotients (HQs) for the compounds investigated. Additionally, the environmental hazard associated to the various compounds measured was assessed through the calculation of the Persistence, Bioaccumulation and Toxicity (PBT) Index, which categorizes compounds according to their environmentally damaging characteristics. The results of the study showed the presence of twenty-four out of the twenty-six compounds analysed at individual concentrations ranging from 5 ng L(-1) to 2 mg L(-1). The highest concentrations corresponded to the ICM iomeprol, found at levels between 424 and 2093 μg L(-1), the analgesic acetaminophen (15-44 μg L(-1)), the diuretic (DIU) furosemide (6-15 μg L(-1)), and the antibiotics (ABIs) ofloxacin and trimethoprim (2-5 μg L(-1)). The lowest levels corresponded to the anti-inflammatory propyphenazone, found at concentrations between 5 and 44 ng L(-1). Differences in terms of concentrations of the analysed compounds have been observed in all the therapeutic groups when comparing the results obtained in this and other recent studies carried out in hospitals with different characteristics from different geographical areas and in different seasons. The screening level risk assessment performed in raw water from the hospital effluent showed that the analgesics and anti-inflammatories (AAFs) acetaminophen, diclofenac, ibuprofen and naproxen, the antibiotics (ABIs) clarithromycin, ofloxacin and trimethoprim, and the β-blocker (BBL) propranolol were present at concentrations leading to HQ values higher than 10, thus indicating high risk. When applying a factor to take into account potential dilution and degradation processes, only the compound ibuprofen showed a HQ higher than 1. Likewise, the cumulative HQ or Toxic Units (TUs) calculated in the raw water for each of the therapeutic groups studied showed that these three classes of drugs were at concentrations high enough to potentially generate high risk to aquatic organisms while taking into account possible dilution and degradation processes only one of them, the AAFs can be considered to represent high risk. Finally, the environmental hazard assessment performed showed that the AAFs diclofenac and ibuprofen and the ABI clarithromycin have the highest, maximum value of 9 of PBT Index due to their inherent environmentally damaging characteristics of persistence, bioaccumulation and toxicity. The methodology followed in the present case study can be taken as a novel approach to classify and categorize pharmaceuticals on the basis of their occurrence in hospital effluents, their derived environmental risks, and their associated environmental hazard. This classification becomes important because it can be used as a model or orientation for hospitals in the process of developing environmentally sustainable policies and as an argument to justify the adoption of advanced, specific treatments for hospital effluents before being discharged into the public sewage system. Copyright © 2015 Elsevier Inc. All rights reserved.

31 CFR 340.8 - Acceptance of bids.

Code of Federal Regulations, 2010 CFR

2010-07-01

... be determined by reference to a specially prepared table of bond yields, a copy of which will be made... representative, will notify any successful bidder of acceptance in the manner and form specified in the public...

25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

Code of Federal Regulations, 2011 CFR

2011-04-01

... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

Code of Federal Regulations, 2014 CFR

2014-04-01

... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

Code of Federal Regulations, 2010 CFR

2010-04-01

... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

Code of Federal Regulations, 2012 CFR

2012-04-01

... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

Code of Federal Regulations, 2013 CFR

2013-04-01

... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

45 CFR 2544.120 - What personal services from a volunteer may be solicited and accepted?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false What personal services from a volunteer may be....120 What personal services from a volunteer may be solicited and accepted? A donation in the form of personal services from a volunteer may be solicited and accepted to assist the Corporation in carrying out...

45 CFR 2544.120 - What personal services from a volunteer may be solicited and accepted?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false What personal services from a volunteer may be....120 What personal services from a volunteer may be solicited and accepted? A donation in the form of personal services from a volunteer may be solicited and accepted to assist the Corporation in carrying out...

45 CFR 2544.120 - What personal services from a volunteer may be solicited and accepted?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false What personal services from a volunteer may be....120 What personal services from a volunteer may be solicited and accepted? A donation in the form of personal services from a volunteer may be solicited and accepted to assist the Corporation in carrying out...

45 CFR 2544.120 - What personal services from a volunteer may be solicited and accepted?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false What personal services from a volunteer may be....120 What personal services from a volunteer may be solicited and accepted? A donation in the form of personal services from a volunteer may be solicited and accepted to assist the Corporation in carrying out...

45 CFR 2544.120 - What personal services from a volunteer may be solicited and accepted?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false What personal services from a volunteer may be....120 What personal services from a volunteer may be solicited and accepted? A donation in the form of personal services from a volunteer may be solicited and accepted to assist the Corporation in carrying out...

19 CFR 174.14 - Amendment of protests.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Protest” at the top of the form. Schedules or other attachments (other than samples or similar exhibits....12(c) as being acceptable on a protest will be acceptable on an amendment to a protest. (e) Place and...

Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.

PubMed

Clop, Alex; Sharaf, Abdoallah; Castelló, Anna; Ramos-Onsins, Sebastián; Cirera, Susanna; Mercadé, Anna; Derdak, Sophia; Beltran, Sergi; Huisman, Abe; Fredholm, Merete; van As, Pieter; Sánchez, Armand

2016-08-26

Taste receptors (TASRs) are essential for the body's recognition of chemical compounds. In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour. Moreover, their relevance in other organs is now becoming evident. In the intestine, they regulate nutrient absorption and gut motility. Upon ligand binding, TASRs activate the appetite-reward circuitry to signal the nervous system and keep body homeostasis. With the aim to identify genetic variation in the swine TASRs and in the genes from the appetite and the reward pathways, we have sequenced the exons of 201 TASRs and appetite-reward genes from 304 pigs belonging to ten breeds, wild boars and to two phenotypically extreme groups from a F2 resource with data on growth and fat deposition. We identified 2,766 coding variants 395 of which were predicted to have a strong impact on protein sequence and function. 334 variants were present in only one breed and at predicted alternative allele frequency (pAAF) ≥ 0.1. The Asian pigs and the wild boars showed the largest proportion of breed specific variants. We also compared the pAAF of the two F2 groups and found that variants in TAS2R39 and CD36 display significant differences suggesting that these genes could influence growth and fat deposition. We developed a 128-variant genotyping assay and confirmed 57 of these variants. We have identified thousands of variants affecting TASRs as well as genes involved in the appetite and the reward mechanisms. Some of these genes have been already associated to taste preferences, appetite or behaviour in humans and mouse. We have also detected indications of a potential relationship of some of these genes with growth and fat deposition, which could have been caused by changes in taste preferences, appetite or reward and ultimately impact on food intake. A genotyping array with 57 variants in 31 of these genes is now available for genotyping and start elucidating the impact of genetic variation in these genes on pig biology and breeding.

7 CFR 1755.30 - List of telecommunications standard contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false List of telecommunications standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.30 List of telecommunications standard contract forms. (a...

7 CFR 1755.30 - List of telecommunications standard contract forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false List of telecommunications standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.30 List of telecommunications standard contract forms. (a...

7 CFR 1755.30 - List of telecommunications standard contract forms.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 11 2012-01-01 2012-01-01 false List of telecommunications standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.30 List of telecommunications standard contract forms. (a...

7 CFR 1755.30 - List of telecommunications standard contract forms.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 11 2013-01-01 2013-01-01 false List of telecommunications standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.30 List of telecommunications standard contract forms. (a...

7 CFR 1755.30 - List of telecommunications standard contract forms.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false List of telecommunications standard contract forms... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.30 List of telecommunications standard contract forms. (a...

77 FR 6094 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... Acquisition Regulation Supplement (DFARS) part 245, Government Property; DD Form 1149, Requisition and Invoice/Shipping Document; DD Form 1348-1A, DoD Single Line item Release/Receipt Document; DD Form 1637, Notice of Acceptance of Inventory Schedules; DD Form 1639, Scrap Warranty; DD Form 1640, Request for Plant Clearance...

Religious aspects of assisted reproduction

PubMed Central

Sallam, HN; Sallam, NH

2016-01-01

Abstract Human response to new developments regarding birth, death, marriage and divorce is largely shaped by religious beliefs. When assisted reproduction was introduced into medical practice in the last quarter of the twentieth century, it was fiercely attacked by some religious groups and highly welcomed by others. Today, assisted reproduction is accepted in nearly all its forms by Judaism, Hinduism and Buddhism, although most Orthodox Jews refuse third party involvement. On the contrary assisted reproduction is totally unacceptable to Roman Catholicism, while Protestants, Anglicans, Coptic Christians and Sunni Muslims accept most of its forms, which do not involve gamete or embryo donation. Orthodox Christians are less strict than Catholic Christians but still refuse third party involvement. Interestingly, in contrast to Sunni Islam, Shi’a Islam accepts gamete donation and has made provisions to institutionalize it. Chinese culture is strongly influenced by Confucianism, which accepts all forms of assisted reproduction that do not involve third parties. Other communities follow the law of the land, which is usually dictated by the religious group(s) that make(s) the majority of that specific community. The debate will certainly continue as long as new developments arise in the ever-evolving field of assisted reproduction. PMID:27822349

Empirical evaluation of the uncanny valley hypothesis fails to confirm the predicted effect of motion.

PubMed

Piwek, Lukasz; McKay, Lawrie S; Pollick, Frank E

2014-03-01

The uncanny valley hypothesis states that the acceptability of an artificial character will not increase linearly in relation to its likeness to human form. Instead, after an initial rise in acceptability there will be a pronounced decrease when the character is similar, but not identical to human form (Mori, 1970/2012). Moreover, it has been claimed but never directly tested that movement would accentuate this dip and make moving characters less acceptable. We used a number of full-body animated computer characters along with a parametrically defined motion set to examine the effect of motion quality on the uncanny valley. We found that improving the motion quality systematically improved the acceptability of the characters. In particular, the character classified in the deepest location of the uncanny valley became more acceptable when it was animated. Our results showed that although an uncanny valley was found for static characters, the deepening of the valley with motion, originally predicted by Mori (1970/2012), was not obtained. Copyright © 2013 Elsevier B.V. All rights reserved.

20 CFR 655.532 - Where and when should attestations be submitted for locations in Alaska?

Code of Federal Regulations, 2010 CFR

2010-04-01

... be accepted for filing or returned by ETA in accordance with § 655.538 within 14 calendar days of the date received by ETA. An attestation which is accepted by ETA solely because it was not reviewed within... be clearly indicated on the Form ETA 9033-A. In order to ensure that an attestation has been accepted...

Alternative acceptance procedures for asphalt mixes.

DOT National Transportation Integrated Search

1992-01-01

By the year 2005, the use of chlorinated solvents is to be eliminated. Faced with this eventuality, VDOT formed a task force to look at alternatives for the acceptance of asphalt mixes. One alternative is to use biodegradable solvents in the extracti...

Buccal Dosage Forms: General Considerations for Pediatric Patients.

PubMed

Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O

2017-02-01

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.

47 CFR 22.213 - Filing of long-form applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Filing of long-form applications. 22.213... PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Competitive Bidding Procedures § 22.213 Filing of long-form applications. After an auction, the Commission will not accept long form applications...

7 CFR 1755.26 - RUS standard contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.26 RUS standard contract forms. (a) The standard loan agreement between RUS and its borrowers... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS standard contract forms. 1755.26 Section 1755.26...

Microwave backscattering theory and active remote sensing of the ocean surface

NASA Technical Reports Server (NTRS)

Brown, G. S.; Miller, L. S.

1977-01-01

The status is reviewed of electromagnetic scattering theory relative to the interpretation of microwave remote sensing data acquired from spaceborne platforms over the ocean surface. Particular emphasis is given to the assumptions which are either implicit or explicit in the theory. The multiple scale scattering theory developed during this investigation is extended to non-Gaussian surface statistics. It is shown that the important statistic for the case is the probability density function of the small scale heights conditioned on the large scale slopes; this dependence may explain the anisotropic scattering measurements recently obtained with the AAFE Radscat. It is noted that present surface measurements are inadequate to verify or reject the existing scattering theories. Surface measurements are recommended for qualifying sensor data from radar altimeters and scatterometers. Additional scattering investigations are suggested for imaging type radars employing synthetically generated apertures.

Fulda AAF, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1972-02-08

62,21~ 62 62.2 62.2 62.6 62.6j 62,6 62 6 0.62.s2 653,.> 100 101 17,11 63 tD 03~ 15 63. 0j, 64#J t,4o^, 64.O04,C 4 ’.cl 64,9>_ ___ 51.4 56 61.7 64,9...STATION hAMi YEARSo _Te_ WET BULB TEMPERA) URE DEPRESSION (F) I 7OTAL 1 TOTAL (F) ~ ~ ~ 1 11 ___ _:_~1~ 24~2 2?2 L.9 B , l B . BbD & Po ___--- I __ __ , I...34,, lOt, Th 1$/ 37 s 44 . 4 14 - 22/_ 31 -I 11 6 / 1 2_ __ JAL 2 7Z.1. 7 .~ TD -e 214267~ 3E75 2# Is- 91 9 ___ I;~~91 90__ 1 .-..- SElm t CX) 4x ’ o 1 ~ Obs

Finthen AAF, Germany (West) Limited Surface Observations Climatic Summary (LISOCS).

DTIC Science & Technology

1983-08-05

3.3 3.5 1.5 .6 .0 .1 Ŗ 311 132 .𔃻 4. . . .13. 2 ?2 311 2 f /t .5 .0 2.1 1. 1 59, 347 ?30 / T- AS .4 5 3s L3 /31 .11 1.7’ .2 164 14l 248b 312 / 73 .9... Nowo righ Tomeev R ... :.. 778199, 95S91 7).2 2.346 1 sO Sl2I 067 P .?IF * P - 93 F Tota : D,,.I..lb 3 I7t)41 6.4o0C $6.2 6.016 1211 3.3 .? "c...4.. 4*3 1.6 .5 .7 ., .2 "󈧼 554 . . . .. H ... III* - Me 441 4 6 .11% T ’S -- . _!a _ . 3 4 _ ’ 0 _ S .,.N,,,. 25546 8’ 36 ൬ 6 .3 *. 347 FS ,O 2 5 P

Revised Uniform Summary of Surface Weather Observations (RUSSWO) Schwaebisch Hall AAF, DL

DTIC Science & Technology

1979-08-17

TOTAL NUMSE3 YF OSERYATIONS4 USAFETAC 0-85 (OL-AI ,O Nivowrano ef lAS OM AMt cosmf G;L(3ohL C’LTl 2 "iC %1sAFPT C SURFACE WINDS AIR -ET!ER S PERCENTAGE...78 _ V_ on rm StATW NAM TUBS .’" ALL A-"H CIASS NIa ( LA T.) SPEED 1i I i MEAN ENTS) I! 1.3 4.6 7.10 1.16 17-21 22-27 28-31 .4-40 Al .47 48 55 ? :56...Il 2.4 W mw_ -- I* . Es _ _ _i n - ___; - 4 jSFTA 0I -- La Ic.-’ Mvw m.- i kb~ !ULA Hua6fOUMAI4 QSFTC 0’ ~.)PvWSOh401~ m aCSI El (,i U Ir i5 IJSAFCTA

OLYMPEX Counterflow Spectrometer and Impactor Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poellot, Michael

The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s ARM Aerial Facility (AAF) Counterflow Spectrometer and Impactor (CSI) probe was flown on the University of North Dakota Cessna Citation research aircraft during the Olympic Mountain Experiment (OLYMPEX). The field campaign took place from November 12 through December 19, 2015, over the Olympic Mountains and coastal waters of Washington State as part of a National Aeronautics and Space Administration (NASA) Global Precipitation Measurement (GPM) validation campaign. The CSI was added to the Citation instrument suite to support the NASA Aerosol-Cloud Ecosystem (ACE) satellite program and flights ofmore » the NASA Lockheed Earth Resources (ER-2) aircraft. ACE funded extra ER-2 flights to focus on clouds that are weakly precipitating, which are also of interest to the DOE Atmospheric System Research (ASR) program.« less

The Joint Staff/J-5 and A-AF CLIC (Center for Low Intensity Conflict) Planning and Policy in Low Intensity Conflict Conference held in Hampton, Virginia on 13-15 December 1988

DTIC Science & Technology

1988-12-15

DA -25> A zz Mi ~ ~ c 0- .I 0...o . fi jO 5 - W U) :: - 4~ ~ -j :.j Oa cc WLJ~ WI 0mZ, Z j CL ZW ~z~ U)L W- I -J W Cc LL, -’ P L 14 C c (A0 WU oI PA-3c5 .c U. 0 owJ o CC N CC z 0 0...0l 0 >- < FL 020 Cl) CLc Zo Co -J 0. C/ z (L 0. -0 ON- CCl) w UoO .j (DO. 0 O * 0 0- 0 a w DA -) z ww I- 0 0 W :)w >.E LUIz 0 1- am 0 0 LC L L.:D 01%

17 CFR 210.4-01 - Form, order, and terminology.

Code of Federal Regulations, 2010 CFR

2010-04-01

... prepared according to U.S. Generally Accepted Accounting Principles or International Financial Reporting... accordance with generally accepted accounting principles will be presumed to be misleading or inaccurate... statements may be prepared according to a comprehensive set of accounting principles, other than those...

Nonlibrary Partnerships: Acceptable Use (and Behavior) in the Web-based Depository.

ERIC Educational Resources Information Center

Brinkerhoff, Kathie

2000-01-01

Discusses problems facing federal depository libraries regarding patron behavior when using Web sites. Topics include acceptable use policies; existing laws and enforcement offices; protecting library property; pornography, including child pornography; sexual harassment; and other forms of staff harassment. (LRW)

How Do Children Restrict Their Linguistic Generalizations? An (Un-)Grammaticality Judgment Study

PubMed Central

Ambridge, Ben

2013-01-01

A paradox at the heart of language acquisition research is that, to achieve adult-like competence, children must acquire the ability to generalize verbs into non-attested structures, while avoiding utterances that are deemed ungrammatical by native speakers. For example, children must learn that, to denote the reversal of an action, un- can be added to many verbs, but not all (e.g., roll/unroll; close/*unclose). This study compared theoretical accounts of how this is done. Children aged 5–6 (N = 18), 9–10 (N = 18), and adults (N = 18) rated the acceptability of un- prefixed forms of 48 verbs (and, as a control, bare forms). Across verbs, a negative correlation was observed between the acceptability of ungrammatical un- prefixed forms (e.g., *unclose) and the frequency of (a) the bare form and (b) alternative forms (e.g., open), supporting the entrenchment and pre-emption hypotheses, respectively. Independent ratings of the extent to which verbs instantiate the semantic properties characteristic of a hypothesized semantic cryptotype for un- prefixation were a significant positive predictor of acceptability, for all age groups. The relative importance of each factor differed for attested and unattested un- forms and also varied with age. The findings are interpreted in the context of a new hybrid account designed to incorporate the three factors of entrenchment, pre-emption, and verb semantics. PMID:23252958

27 CFR 19.634 - Computer-generated reports and transaction forms.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

27 CFR 19.634 - Computer-generated reports and transaction forms.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

27 CFR 19.634 - Computer-generated reports and transaction forms.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

7 CFR 1755.28 - Notice and publication of listed contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Notice and publication of listed contract forms. 1755... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.28 Notice and publication of listed contract forms. (a) Notice...

7 CFR 1755.29 - Promulgation of new or revised contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Promulgation of new or revised contract forms. 1755... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.29 Promulgation of new or revised contract forms. RUS may...

27 CFR 19.634 - Computer-generated reports and transaction forms.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

IMPROVING WILLINGNESS-TO-ACCEPT RESPONSES USING ALTERNATE FORMS OF COMPENSATION

EPA Science Inventory

The purpose of this project is to design a pilot survey to investigate why surveys that ask willingness-to-accept compensation questions so often yield unreliable data and whether respondents would find alternate modes of compensation (specifically, public goods) more acceptab...

Advances in solid dosage form manufacturing technology.

PubMed

Andrews, Gavin P

2007-12-15

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pharmaceutical manufacturing processes currently in existence for the production of solid oral dosage forms are associated with significant disadvantages and in many instances provide many processing problems. Therefore, it is well accepted that there is an increasing need for alternative processes to dramatically improve powder processing, and more importantly to ensure that acceptable, reproducible solid dosage forms can be manufactured. Consequently, pharmaceutical companies are beginning to invest in innovative processes capable of producing solid dosage forms that better meet the needs of the patient while providing efficient manufacturing operations. This article discusses two emerging solid dosage form manufacturing technologies, namely hot-melt extrusion and fluidized hot-melt granulation.

Evaluating Practice-Based Learning and Improvement: Efforts to Improve Acceptance of Portfolios

PubMed Central

Fragneto, Regina Y.; DiLorenzo, Amy Noel; Schell, Randall M.; Bowe, Edwin A.

2010-01-01

Introduction The Accreditation Council for Graduate Medical Education (ACGME) recommends resident portfolios as 1 method for assessing competence in practice-based learning and improvement. In July 2005, when anesthesiology residents in our department were required to start a portfolio, the residents and their faculty advisors did not readily accept this new requirement. Intensive education efforts addressing the goals and importance of portfolios were undertaken. We hypothesized that these educational efforts improved acceptance of the portfolio and retrospectively audited the portfolio evaluation forms completed by faculty advisors. Methods Intensive education about the goals and importance of portfolios began in January 2006, including presentations at departmental conferences and one-on-one education sessions. Faculty advisors were instructed to evaluate each resident's portfolio and complete a review form. We retrospectively collected data to determine the percentage of review forms completed by faculty. The portfolio reviews also assessed the percentage of 10 required portfolio components residents had completed. Results Portfolio review forms were completed by faculty advisors for 13% (5/38) of residents during the first advisor-advisee meeting in December 2005. Initiation of intensive education efforts significantly improved compliance, with review forms completed for 68% (26/38) of residents in May 2006 (P < .0001) and 95% (36/38) in December 2006 (P < .0001). Residents also significantly improved the completeness of portfolios between May and December of 2006. Discussion Portfolios are considered a best methods technique by the ACGME for evaluation of practice-based learning and improvment. We have found that intensive education about the goals and importance of portfolios can enhance acceptance of this evaluation tool, resulting in improved compliance in completion and evaluation of portfolios. PMID:22132291

Evaluating practice-based learning and improvement: efforts to improve acceptance of portfolios.

PubMed

Fragneto, Regina Y; Dilorenzo, Amy Noel; Schell, Randall M; Bowe, Edwin A

2010-12-01

The Accreditation Council for Graduate Medical Education (ACGME) recommends resident portfolios as 1 method for assessing competence in practice-based learning and improvement. In July 2005, when anesthesiology residents in our department were required to start a portfolio, the residents and their faculty advisors did not readily accept this new requirement. Intensive education efforts addressing the goals and importance of portfolios were undertaken. We hypothesized that these educational efforts improved acceptance of the portfolio and retrospectively audited the portfolio evaluation forms completed by faculty advisors. Intensive education about the goals and importance of portfolios began in January 2006, including presentations at departmental conferences and one-on-one education sessions. Faculty advisors were instructed to evaluate each resident's portfolio and complete a review form. We retrospectively collected data to determine the percentage of review forms completed by faculty. The portfolio reviews also assessed the percentage of 10 required portfolio components residents had completed. Portfolio review forms were completed by faculty advisors for 13% (5/38) of residents during the first advisor-advisee meeting in December 2005. Initiation of intensive education efforts significantly improved compliance, with review forms completed for 68% (26/38) of residents in May 2006 (P < .0001) and 95% (36/38) in December 2006 (P < .0001). Residents also significantly improved the completeness of portfolios between May and December of 2006. Portfolios are considered a best methods technique by the ACGME for evaluation of practice-based learning and improvment. We have found that intensive education about the goals and importance of portfolios can enhance acceptance of this evaluation tool, resulting in improved compliance in completion and evaluation of portfolios.

12 CFR 563c.1 - Form and content of financial statements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ACCOUNTING REQUIREMENTS Form and Content of Financial Statements § 563c.1 Form and content of financial... statements shall: (1) Be prepared and presented in accordance with generally accepted accounting principles... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Form and content of financial statements. 563c...

NEVADA TEST SITE WASTE ACCEPTANCE CRITERIA

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. DEPARTMENT OF ENERGY, NATIONAL NUCLEAR SECURITY ADMINISTRATION, NEVADA SITE OFFICE

This document establishes the U. S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site will accept low-level radioactive and mixed waste for disposal. Mixed waste generated within the State of Nevada by NNSA/NSO activities is accepted for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the Nevada Test Site Area 3 and Area 5 Radioactive Waste Management Site for storage or disposal.

27 CFR 73.11 - What are the required components and controls for acceptable electronic signatures?

Code of Federal Regulations, 2010 CFR

2010-04-01

... components and controls for acceptable electronic signatures? 73.11 Section 73.11 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES ELECTRONIC SIGNATURES; ELECTRONIC SUBMISSION OF FORMS Electronic Signatures § 73.11...

13 CFR 114.108 - What if my claim is approved?

Code of Federal Regulations, 2010 CFR

2010-01-01

... agent or legal representative the forms necessary to indicate satisfaction of your claim and your acceptance of the payment. Acceptance by you, your agent or your legal representative of any award, compromise or settlement releases all your claims against the United States under the Federal Tort Claims Act...

Acculturation or Development? Autonomy Expectations among Ethnic German Immigrant Adolescents and Their Native German Age-Mates

ERIC Educational Resources Information Center

Titzmann, Peter F.; Silbereisen, Rainer K.

2012-01-01

This longitudinal study compared immigrant and native adolescents' expectations concerning the timing of conventional socially acceptable and oppositional less socially acceptable forms of autonomy. Based on normative development and a collectivist background among immigrants, both developmental and acculturative change was expected. The sample…

The Influence of Teachers' Conceptions of Teaching and Learning on Their Technology Acceptance

ERIC Educational Resources Information Center

Teo, Timothy; Zhou, Mingming

2017-01-01

Prior research has attempted to incorporate different personal variables within extant theories of technology acceptance models (TAMs). This study further extends TAM by incorporating teachers' conceptions of teaching and learning (CoTL) in two forms: constructivist and traditional conceptions. The moderating effects of teachers' demographic…

46 CFR 28.50 - Definition of terms used in this part.

Code of Federal Regulations, 2012 CFR

2012-10-01

... forms of marine animal and plant life, except marine mammals and birds. Fish processing vessel means a....S. Coast Guard Sector Office or Marine Inspection Office, or an accepted organization, or a... an individual or organization that has been accepted by the local Officer-in-Charge, Marine...

46 CFR 28.50 - Definition of terms used in this part.

Code of Federal Regulations, 2011 CFR

2011-10-01

... forms of marine animal and plant life, except marine mammals and birds. Fish processing vessel means a....S. Coast Guard Sector Office or Marine Inspection Office, or an accepted organization, or a... an individual or organization that has been accepted by the local Officer-in-Charge, Marine...

Smart consumer products with a pathfinder product development strategy

NASA Astrophysics Data System (ADS)

Robertson, Alec

1994-09-01

It is generally acknowledged that technologies diffuse through industry and that the rate of diffusion varies both within different industries and according to the circumstances. Innovation is a process involving risk, especially during the adoption and adaptation of a powerful new technology. Central to a consumer products success using new technology is the quality of their designs and the nature of their forms. Form is of prime importance in influencing the purchasing decisions of consumers and it is also influential in determining the relationships between people in its use environment. The acceptance of a new product into the world is often unduly ad hoc. Many failures are created for each success and there are few guidelines to assist the formulation of a strategy for creating an appropriate form. It is suggested below that success of consumer products incorporating 'smart structures' may be determined not only by the function of products and systems, but also by the form they take. The definition of a desirable product form depends entirely on the point of view taken: technological, commercial, ecological, cultural, and social. However any design using new will incorporate the old and the new. The probability of acceptance of a new product is enhanced by maintaining a fine balance between imaginative and creative form and that with which people are familiar and prefer: a new design may be rejected if it is too novel and unfamiliar, or too traditional. The acceptance of a new product and its subsequent development depends on the success designers and engineers have when dealing with the initial forms, particularly using new technology such as 'smart structures'.

Accounting for unprotected sex: stories of agency and acceptability.

PubMed

Rhodes, Tim; Cusick, Linda

2002-07-01

Based on the idea that risks are knowable, calculable and preventable, dominant social scientific and health promotion discourses foster an image of individual risk control and responsibility. The presentation of the self is a moral enterprise. Accounts of unprotected sex by HIV positive people who have the potential to transmit HIV to their sexual partners can be particularly morally charged. Drawing on 73 depth qualitative interviews with HIV positive people and their sexual partners, this paper explores how the interview accounts of unprotected sex can illuminate the way in which the self is presented within the context of situated norms of risk acceptability and moral responsibility. We identify two forms of account: stories of agency; and stories of acceptability. Stories of agency tend to deny agency and abdicate individual responsibility given the circumstances, and were also a key feature of accounts in which the sexual partners of HIV positive people were placed at risk of HIV transmission. Categories of appeal included the denial of agency as a consequence of: risk calculus and condom accidents; alcohol and drug effects; powerlessness and coercion; and forces of nature. By contrast, stories of acceptability tend to justify unprotected sex as acceptable. Categories of appeal included: HIV positive concordance; and commitment in relationships. Other forms of justification included: alter responsibility; and intentional HIV transmission. We conclude that accounts of risk management are risk managed. We call for greater attention by social scientists to the way in which accounts are constructed, and in particular, to 'anti-rational' forms of explanation within accounts.

77 FR 21105 - Agency Information Collection Activities: Form G-1145, Revision of a Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-09

... and/or text message on their cell phone that their application or petition has been accepted, they are requested to provide their email address and/or cell phone number on Form G-1145, and attach the form to the...

Speech sound discrimination training improves auditory cortex responses in a rat model of autism

PubMed Central

Engineer, Crystal T.; Centanni, Tracy M.; Im, Kwok W.; Kilgard, Michael P.

2014-01-01

Children with autism often have language impairments and degraded cortical responses to speech. Extensive behavioral interventions can improve language outcomes and cortical responses. Prenatal exposure to the antiepileptic drug valproic acid (VPA) increases the risk for autism and language impairment. Prenatal exposure to VPA also causes weaker and delayed auditory cortex responses in rats. In this study, we document speech sound discrimination ability in VPA exposed rats and document the effect of extensive speech training on auditory cortex responses. VPA exposed rats were significantly impaired at consonant, but not vowel, discrimination. Extensive speech training resulted in both stronger and faster anterior auditory field (AAF) responses compared to untrained VPA exposed rats, and restored responses to control levels. This neural response improvement generalized to non-trained sounds. The rodent VPA model of autism may be used to improve the understanding of speech processing in autism and contribute to improving language outcomes. PMID:25140133

Gray AAF, Fort Lewis, Lacey, Washington. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1979-02-23

99.6Jjj 2 9, 1 99.199.09 10 TOTAL NUMBER OF OBSERVATIONS . . FOr USAFETAC ,Ś. 0-14-5 (OL 1) RtA0U$ tD fl0NSOFTK$ t APE OB$I(X/I .. " • ) ,;Tt...YEAP I I 2 MONTHS td 2𔃾 30 10 31 41~ 33 -02ro’. 4 3) 7 33 4 21 1( 1 -T.41 --Z4 +4 . - .. 17 2 -,-ś 29 3. 45 45 7 Z • 7 19 3Q 31 4 ’ 34 34 ?7 74 -- 1...31 h It7 Th1 -- II - -" 6 26/ 25 95 td ’ go .0I t- 116 116 159) 336 90, --- Z|47 , 22/ 21 2 2 1 41 43 57 134 0 -12T 4~7 _ _ _ _ 0 40 29 q -8/- 7 9 11

Wertheim Germany AAF. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1972-02-17

0600*080C cUS$ Enets (45 s SPEED I 3.0 4- MEAN (KNTS) 1 ! 137 1 1316 1 7.21 222 28.33 38.5 AO% IN OIL I -- SPEI N L]sA......9nE".,9 __ I __I __ __ i2...26#71 286.1 33901 ’.Sol 346 37 2! 35761 137 Zi 37.8 7,2 37,2 35762 38.2i 2: 700 1 92 2270 267 8133_6 I>70 i25127,2[ 288 3. Sat~:i 3626 37:7 38.71 28...43.7180 i 3~ -32 43.p 43. 43,2 -r54.7 713 43,74.7! 43-2, 3 71.7 ____ __43.4 43. 43 43.43 4342 434 43 412 3~7 43437 6 3 j. 43.71 4?.7 1400-3 43 1 C 43,9

Cloud characteristics, thermodynamic controls and radiative impacts during the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giangrande, Scott E.; Feng, Zhe; Jensen, Michael P.

Routine cloud, precipitation and thermodynamic observations collected by the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) and Aerial Facility (AAF) during the 2-year US Department of Energy (DOE) ARM Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign are summarized. These observations quantify the diurnal to large-scale thermodynamic regime controls on the clouds and precipitation over the undersampled, climatically important Amazon basin region. The extended ground deployment of cloud-profiling instrumentation enabled a unique look at multiple cloud regimes at high temporal and vertical resolution. This longer-term ground deployment, coupled with two short-term aircraft intensive observing periods, allowed new opportunitiesmore » to better characterize cloud and thermodynamic observational constraints as well as cloud radiative impacts for modeling efforts within typical Amazon wet and dry seasons.« less

SPAR electrophoretic separation experiments, part 2

NASA Technical Reports Server (NTRS)

Cosmi, F. M.

1978-01-01

The opportunity to use a sounding rocket for separation experiments is a logical continuation of earlier electrophoresis demonstrations and experiments. A free-flow electrophoresis system, developed under the Advanced Applications Flight Experiment (AAFE) Program, was designed so that it would fit into a rocket payload. The SPAR program provides a unique opportunity to complete the intial stages of microgravity testing prior to any Shuttle applications. The objective of the work described in this report was to ensure proper operating parameters for the defined experimental samples to be used in the SPAR Electrophoretic Separation Experiment. Ground based experiments were undertaken not only to define flight parameters but also to serve as a point of comparison for flight results. Possible flight experiment problem areas were also studied such as sample interaction due to sedimentation, concentration effects and storage effects. Late in the program anomalies of field strengths and buffer conductivities were also investigated.

Air-borne heavy metal contamination to dietary vegetables: a case study from India.

PubMed

Pandey, J; Pandey, Richa; Shubhashish, K

2009-12-01

Contamination of edible parts of three dietary vegetables, Spinach (Spinacia oleracea L.), Radish (Raphanus sativus L.), and Tomato (Lycopersicon esculentum Mill.) by air-borne cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), and lead (Pb) was determined using pot culture experiments at three sites in the city of Varanasi, India. The data revealed that although Cr and Cu in vegetables remained below their safe limits, about 68% of the total samples contained Cd, Ni, and Pb above their respective safe limits of 1.5, 1.5, and 2.5 μg g(-1). Site wise synchrony and air accumulation factor (AAF) indicated that atmospheric deposition was the main contributor of metal contamination to vegetables. The study suggests that if the present trends of atmospheric deposition are continued, air-borne heavy metals will contaminate the agricultural produce with long-term health implications.

ARM Airborne Carbon Measurements VI (ARM-ACME VI) Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biraud, Sebastien

2017-05-01

From October 1, 2015 through September 30, 2016, AAF deployed a Cessna 206 aircraft over the Southern Great Plains, collecting observations of trace gas mixing ratios over the ARM/SGP Central Facility. The aircraft payload included two Atmospheric Observing Systems (AOS Inc.) analyzers for continuous measurements of CO2, and a 12-flask sampler for analysis of carbon cycle gases (CO2, CO, CH4, N2O, 13CO2). The aircraft payload also includes solar/infrared radiation measurements. This research (supported by DOE ARM and TES programs) builds upon previous ARM-ACME missions. The goal of these measurements is to improve understanding of: (a) the carbon exchange of themore » ARM region; (b) how CO2 and associated water and energy fluxes influence radiative forcing, convective processes, and CO2 concentrations over the ARM region, and (c) how greenhouse gases are transported on continental scales.« less

Cloud characteristics, thermodynamic controls and radiative impacts during the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) experiment

DOE PAGES

Giangrande, Scott E.; Feng, Zhe; Jensen, Michael P.; ...

2017-12-06

Routine cloud, precipitation and thermodynamic observations collected by the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) and Aerial Facility (AAF) during the 2-year US Department of Energy (DOE) ARM Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign are summarized. These observations quantify the diurnal to large-scale thermodynamic regime controls on the clouds and precipitation over the undersampled, climatically important Amazon basin region. The extended ground deployment of cloud-profiling instrumentation enabled a unique look at multiple cloud regimes at high temporal and vertical resolution. This longer-term ground deployment, coupled with two short-term aircraft intensive observing periods, allowed new opportunitiesmore » to better characterize cloud and thermodynamic observational constraints as well as cloud radiative impacts for modeling efforts within typical Amazon wet and dry seasons.« less

Fort Bragg, Fayetteville, North Carolina. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1972-02-18

SIMMUNS AAF 62-7o MAY STATION STATION AM TSAOS NONIN ALI WEATHER 0600-0800 CLASS NOUON (L N.T.) CONDITION SPEED MEAN (KNTS) 1- 3 4.6 7-10 11 . 16 17.21 22...7o a973 979 1,0 Vzo V3 "t$ 3 94 e 71 937U 9Y DIP0 9Th 0 95,0 95𔃺 9590 9570 2o600 895’ 91.0 91,11 92.7 93;4 9496 94,7 95.2 95,5 95,6 9506 95.7 95.7 95...92,4 a2500 9093 V49VV31 9" 93f vjf - 9 V* v3ti f 9 3,-W- 1 3*7 V3,7, " -9, ŗ, S2000 91,4 93.2 94,2 94.8 9590 9$14 95,1 95,1 95,2 95,2 95,2 95.2 95,2

Surface Observation Climatic Summaries (SOCS) for Gila Bend AAF, Arizona

DTIC Science & Technology

1989-11-01

14 35.9 10.368 663 159 351 656 0 663 15-17 35.2 9.804 615 149 317 612 0 663 18-20 37.1 9.250 414 72 237 409 0 663 21-23 36.1 10.284 113 26 59 113 0 663...0 0 0 0 0 03-05 .0 .000 0 0 0 0 0 0 06-08 52.5 10.326 605 2 554 351 73 605 09-11 53.6 9.359 682 0 651 375 92 682 12-14 52.6 8.973 652 0 622 396 71 652...GE25 OBS GE1O GE1S GE25 OBS GElO GE15 GE25 08 GElI ! GES L E2’ OBS CATEGORY A 1.9 .4 702 5.2 .3 655 1 ., ., . .9 . CATEGORY B 2.6 .7 .1 702 b.9 1.5 .2

13 CFR 107.630 - Requirement for Licensees to file financial statements with SBA (Form 468).

Code of Federal Regulations, 2010 CFR

2010-01-01

... Form 468 must be audited by an independent public accountant acceptable to SBA. (2) Insurance requirement for public accountant. Unless SBA approves otherwise, your independent public accountant must...

Coppicing to convert cull austrailian toon, tropical ash to acceptable trees

Treesearch

Gerald A. Walters; Herbert L. Wick

1973-01-01

Coppicing provides a method of converting cull sapling and pole-size Australian toon (Toono australis) and tropical ash (Fraxillus uhdel) trees to "acceptable trees." In trial plots on the island of Hawaii, stumps of both species sprouted, resulting in a high percentage of vigorous, well-formed sterns. Codominant stems on...

14 CFR 330.37 - Are carriers which participate in this program subject to audit?

Code of Federal Regulations, 2011 CFR

2011-01-01

... engagement must be performed in accordance with generally accepted professional standards applicable to... expenses and revenues presented to the Department are in accordance with the official accounting records of... Form 10-Q (for availability, see 17 CFR 249.0-1(b)), and consistent with Generally Accepted Accounting...

14 CFR 330.37 - Are carriers which participate in this program subject to audit?

Code of Federal Regulations, 2012 CFR

2012-01-01

... engagement must be performed in accordance with generally accepted professional standards applicable to... expenses and revenues presented to the Department are in accordance with the official accounting records of... Form 10-Q (for availability, see 17 CFR 249.0-1(b)), and consistent with Generally Accepted Accounting...

14 CFR 330.37 - Are carriers which participate in this program subject to audit?

Code of Federal Regulations, 2014 CFR

2014-01-01

... engagement must be performed in accordance with generally accepted professional standards applicable to... expenses and revenues presented to the Department are in accordance with the official accounting records of... Form 10-Q (for availability, see 17 CFR 249.0-1(b)), and consistent with Generally Accepted Accounting...

14 CFR 330.37 - Are carriers which participate in this program subject to audit?

Code of Federal Regulations, 2010 CFR

2010-01-01

... engagement must be performed in accordance with generally accepted professional standards applicable to... expenses and revenues presented to the Department are in accordance with the official accounting records of... Form 10-Q (for availability, see 17 CFR 249.0-1(b)), and consistent with Generally Accepted Accounting...

14 CFR 330.37 - Are carriers which participate in this program subject to audit?

Code of Federal Regulations, 2013 CFR

2013-01-01

... engagement must be performed in accordance with generally accepted professional standards applicable to... expenses and revenues presented to the Department are in accordance with the official accounting records of... Form 10-Q (for availability, see 17 CFR 249.0-1(b)), and consistent with Generally Accepted Accounting...

Grammaticality, Acceptability, and Probability: A Probabilistic View of Linguistic Knowledge

ERIC Educational Resources Information Center

Lau, Jey Han; Clark, Alexander; Lappin, Shalom

2017-01-01

The question of whether humans represent grammatical knowledge as a binary condition on membership in a set of well-formed sentences, or as a probabilistic property has been the subject of debate among linguists, psychologists, and cognitive scientists for many decades. Acceptability judgments present a serious problem for both classical binary…

33 CFR 17.05-5 - Acceptance and disbursement of gifts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... gifts. 17.05-5 Section 17.05-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL UNITED STATES COAST GUARD GENERAL GIFT FUND Administration § 17.05-5 Acceptance and disbursement of gifts. (a) The immediate receiving person shall give a proper receipt on the proper form used...

41 CFR 102-38.290 - What types of payment may we accept?

Code of Federal Regulations, 2010 CFR

2010-07-01

... limited to, the following: (a) U.S. currency or any form of credit instrument made payable on demand in U.S. currency, e.g., cashier's check, money order. Promissory notes and postdated credit instruments are not acceptable. (b) Irrevocable commercial letters of credit issued by a United States bank...

The Implementation of a Positive Behaviour Management Programme in a Primary Classroom: A Case Study.

ERIC Educational Resources Information Center

Atherley, Carole

1990-01-01

Positive behavior management has been recommended as a more acceptable form of classroom management than traditional behavioral modification. This paper discusses the application of stimulus and contingency control methods (positive behavior management) to elicit more socially and academically acceptable behavior from elementary school children.…

Classification Accuracy and Acceptability of the Integrated Screening and Intervention System Teacher Rating Form

ERIC Educational Resources Information Center

Daniels, Brian; Volpe, Robert J.; Fabiano, Gregory A.; Briesch, Amy M.

2017-01-01

This study examines the classification accuracy and teacher acceptability of a problem-focused screener for academic and disruptive behavior problems, which is directly linked to evidence-based intervention. Participants included 39 classroom teachers from 2 public school districts in the Northeastern United States. Teacher ratings were obtained…

42 CFR 436.407 - Types of acceptable documentary evidence of citizenship.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Department of State issues this. A U.S. passport does not have to be currently valid to be accepted as... issues for naturalization. (3) A Certificate of U.S. Citizenship (DHS Forms N-560 or N-561.) Department of Homeland Security issues certificates of citizenship to individuals who derive citizenship through...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

19 CFR 134.45 - Approved markings of country name.

Code of Federal Regulations, 2011 CFR

2011-04-01

... “Brasil” for “Brazil” and “Italie” for “Italy,” are acceptable. (c) Adjectival form. The adjectival form... “Brazil nuts” are unacceptable. (d) Colonies, possessions, or protectorates. The name of a colony...

19 CFR 134.45 - Approved markings of country name.

Code of Federal Regulations, 2014 CFR

2014-04-01

... “Brasil” for “Brazil” and “Italie” for “Italy,” are acceptable. (c) Adjectival form. The adjectival form... “Brazil nuts” are unacceptable. (d) Colonies, possessions, or protectorates. The name of a colony...

19 CFR 134.45 - Approved markings of country name.

Code of Federal Regulations, 2013 CFR

2013-04-01

... “Brasil” for “Brazil” and “Italie” for “Italy,” are acceptable. (c) Adjectival form. The adjectival form... “Brazil nuts” are unacceptable. (d) Colonies, possessions, or protectorates. The name of a colony...

19 CFR 134.45 - Approved markings of country name.

Code of Federal Regulations, 2012 CFR

2012-04-01

... “Brasil” for “Brazil” and “Italie” for “Italy,” are acceptable. (c) Adjectival form. The adjectival form... “Brazil nuts” are unacceptable. (d) Colonies, possessions, or protectorates. The name of a colony...

76 FR 28303 - Requiring Residents Who Live Outside the United States To File Petitions According to Form...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... Special Immigrant, Form I-360, may be filed, accepted, processed and approved through form instructions... Petition for Amerasian, Widow(er), or Special Immigrant, Form I-360, on behalf of a widow or widower may be... immigrate to the United States. A Petition for Amerasian, Widow(er), or Special Immigrant is used by an...

Validation of the Chronic Pain Acceptance Questionnaire (CPAQ) in Cantonese-speaking Chinese patients.

PubMed

Cheung, Michelle N; Ning, Michelle Cheung; Wong, Tony C M; Ming, Tony Wong Chi; Yap, Jacqueline C M; Mae, Jacqueline Yap Chooi; Chen, Phoon P; Ping, Chen Phoon

2008-09-01

Acceptance of chronic pain has become an important concept in understanding and predicting that chronic pain sufferers can remain engaged with meaningful aspects of life. Assessment of acceptance has been facilitated by the development of Chronic Pain Acceptance Questionnaire (CPAQ). In this study, we aimed to test the reliability and validity of translated Chinese version of CPAQ to use this important tool in the future management of Hong Kong Chinese patients with chronic nonmalignant pain. Content validity was established by consensus formed among a panel of 5 experts in clinical psychology and pain specialty during the process of forward and backward translations. Test-retest reliability was examined by completing the Chinese CPAQ twice, 2 weeks apart, by 54 patients. A total of 224 Chinese patients with chronic nonmalignant pain attending our cluster multidisciplinary pain clinic were asked to complete a battery of psychometric instruments in Chinese, including an intake form for demographic data, Hospital Anxiety and Depression Score (HADS), Medical Outcome Study Short Form 36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Self-Efficacy Questionnaire (PSEQ). Analysis results showed that Chinese CPAQ had good test-retest reliability (intraclass correlation coefficient, 0.79) and internal consistency reliability (Cronbach alpha = 0.79). The Chinese CPAQ score was significantly correlated to anxiety, depression, pain catastrophizing, pain self-efficacy, and physical and psychosocial disability. Scree plot and Principal Components Factor analysis confirmed the same 2-factor construct as the original English CPAQ. Construct validity of the Chinese CPAQ can therefore be supported. In conclusion, the Chinese CPAQ is a reliable clinical assessment tool with valid construct for acceptance measurement in our heterogeneous Chinese patients sample with chronic nonmalignant pain. This article confirms the reliability and validity of a Chinese version of the CPAQ. The Chinese CPAQ can then be used by pain clinicians caring for Chinese chronic pain patients worldwide for acceptance-based psychometric assessment as well as therapies.

[General aspects of homeopathy].

PubMed

Avello L, Marcia; Avendaño O, Cristian; Mennickent C, Sigrid

2009-01-01

Homeopathic medicine is a type of therapy that appeared in Europe at the end of the eighteenth century. At the present time, it is widely accepted in developed countries as a form of alternative medicine. In Chile, health regulation includes homeopathy as pharmaceutical products and homeopathy is also considered a form of complementary medicine, that is well accepted by the public. The scientific rationale of homeopathy is based on an empiric type of thought that goes from the general to the particular. The symptoms that are valued are those that are particular to each sick individual. It uses diluted solutions of plants, minerals, animals and even venoms. There are basically two hypotheses to explain its mechanisms of action: The "immunological memory" and the "memory of water" or the transmission of electromagnetic information of the water. There still is needed to perform new studies to scientifically assess homeopathy and its usefulness, as an accepted alternative therapy.

Adolescents' unconditional acceptance by parents and teachers and educational outcomes: A structural model of gender differences.

PubMed

Makri-Botsari, Evi

2015-08-01

The purpose of this study was to detect gender specific patterns in the network of relations between unconditionality of parental and teacher acceptance in the form of unconditional positive regard and a range of educational outcomes, as indexed by academic self-perception, academic intrinsic motivation, and academic achievement. To test the role of gender as a moderator, a multi-group analysis was employed within the framework of structural equation modelling with increasing restrictions placed on the structural paths across genders. The results on a sample of 427 adolescents in grades 7-9 showed that conditionality of acceptance undermined level of perceived acceptance for both social agents. Moreover, unconditionality of teacher acceptance exerted stronger influences on students' educational outcomes than unconditionality of parental acceptance, with effect sizes being larger for girls than for boys. Copyright © 2015 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Pronoun Preferences of Children in a Language without Typical Third-Person Pronouns

ERIC Educational Resources Information Center

Iraola Azpiroz, Maialen; Santesteban, Mikel; Sorace, Antonella; Ezeizabarrena, Maria-José

2017-01-01

This study presents comprehension data from 6-7-and 8-10-year-old children as well as adults on the acceptability of null vs overt anaphoric forms (the demonstrative "hura" "that" and the quasipronoun bera "(s)he, him-/herself") in Basque, a language without true third-person pronouns. In an acceptability judgement…

77 FR 61042 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing and Order Granting...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

... requires, among other things, that ICC accept or reject trades submitted for clearance that are executed... other things, that ICC accept or reject trades submitted for clearance that are not executed... the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or Send an email to...

A Review of Research Instruments Assessing Levels of Student Acceptance of Evolution

ERIC Educational Resources Information Center

Yasri, Pratchayapong

2014-01-01

Darwin's theory of evolution by means of natural selection, called evolution for short, is perceived as a unifying theme in biology, forming a major part of all biology syllabuses. It is reported that student acceptance of evolution associates with conceptual understandings of biological contents, nature of science, as well as motivations to…

NEVADA TEST SITE WASTE ACCEPTANCE CRITERIA, JUNE 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

U.S. DEPARTMENT OF ENERGY, NATIONAL NUCLEAR SECURITY ADMINISTRATION NEVADA SITE OFFICE

This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive (LLW) and mixed waste (MW) for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex (RWMC) for storage or disposal.

Nevada Test Site Waste Acceptance Criteria

DOE Office of Scientific and Technical Information (OSTI.GOV)

U. S. Department of Energy, National Nuclear Security Administration Nevada Site Office

This document establishes the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) waste acceptance criteria (WAC). The WAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive (LLW) and mixed waste (MW) for disposal. It includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex (RWMC) for storage or disposal.

Healthcare professionals and the ethics of healthcare marketing.

PubMed

Hammond, Kevin L; Jurkus, Anthony F

1993-01-01

The article explores marketing ethics considerations in the application of marketing to healthcare. While we realize that acceptance of healthcare marketing by all stakeholders is important for successful marketing, we emphasize its level of acceptance by healthcare professionals. The high levels of resistance to advertising and other forms of healthcare marketing by healthcare professionals has been largely based on the grounds that the practices are unethical. The nature of the resistance thus invites this exploration of healthcare marketing (and the marketing concept), marketing ethics, and the acceptance (rejection) by healthcare professionals of healthcare marketing.

Optical properties of nonimaging concentrators with corrugated reflectors

NASA Astrophysics Data System (ADS)

Roennelid, Mats; Perers, Bengt; Karlsson, Bjorn

1994-09-01

A ray tracing study has been performed on the optical properties of cylindrical nonimaging concentrators with linear corrugated reflectors. The corrugations are assumed to be V-formed and to have an extension parallel to the meridian plane of the concentrators. It is shown that the acceptance angle for radiation incident in the meridian plane can be increased for moderate corrugations. This increased acceptance is balanced by a decreased acceptance of radiation from other directions. Calculations of angular acceptance for a 2X compound parabolic concentrator is presented. It is shown that the annual irradiation on a solar collector with booster reflector can be increased if corrugated reflectors are used instead of smooth reflectors.

Acceptability of physical examination by male doctors in medical care: Taking breast palpation as an example.

PubMed

Wang, Yan-jie; Yang, Jie; Kang, Li-xia; Jia, Zhen; Chen, Dong-ming; Zhang, Ping; Feng, Zhan-chun

2015-10-01

In this study, we conducted an investigation among medical workers, patients and college students concerning their acceptability of breast palpation performed by male doctors (hereinafter referred to as "acceptability", or "the examination", respectively, if not otherwise indicated), to get the information about their acceptability and reasons for accepting or declining the examination among the three population. A questionnaire investigation was conducted in 500 patients with breast diseases, 700 students of medical colleges, and 280 medical workers working in hospitals. The subjects were asked to choose between two options: accept or do not accept (the examination). The subjects were asked to fill out the questionnaire forms on free and anonymous basis and the questionnaire forms were collected on spot, immediately after completion. The questionnaires collected were coded, sorted out and checked. Data of the eligible questionnaires were input into Epidata software and analyzed by SPSS. Upon the establishment of the database, the intra-group data were tested by utilizing χ(2) test. Among 1480 questionnaires, 1293 (90.41%) questionnaires were retrieved. Our results showed that 56.78% of patients reported that they could accept breast palpation by male doctors. About 59.66% of medical staff expressed their acceptance of the examination, but only 35.03% of students said the examination. On the basis of this study, we were led to conclude that the examination is not well accepted by different populations, and therefore, (1) medical professionals and administrators should pay attention to the gender-related ethics in their practice and the feeling of patients should be respected when medical examinations involve private or sensitive body parts; (2) to this end, related departments should be properly staffed with doctors of both sexes, and this is especially true of the departments involving the examination or treatment of private or sensitive body parts; (3) health education should, among other things, include helping female patients to overcome the fear and anxiety in such examinations. This is of great importance since some women may miss the opportunity to get timely diagnosis.

The free form XR photovoltaic concentrator: a high performance SMS3D design

NASA Astrophysics Data System (ADS)

Cvetkovic, Aleksandra; Hernandez, Maikel; Benítez, Pablo; Miñano, Juan C.; Schwartz, Joel; Plesniak, Adam; Jones, Russ; Whelan, David

2008-08-01

A novel photovoltaic concentrator is presented. The goal is to achieve high concentration design with high efficiency and high acceptance angle that in the same time is compact and convenient for thermal and mechanical management. This photovoltaic system is based on 1 cm2 multi-junction tandem solar cells and an XR concentrator. The XR concentrator in this system is an SMS 3D design formed by one reflective (X) and one refractive (R) free-form surfaces (i.e., without rotational or linear symmetry) and has been chosen for its excellent aspect ratio and for its ability to perform near the thermodynamic limit. It is a mirror-lens device that has no shadowing elements and has square entry aperture (the whole system aperture area is used for collecting light). This large acceptance angle relaxes the manufacturing tolerances of all the optical and mechanical components of the system included the concentrator itself and is one of the keys to get a cost competitive photovoltaic generator. For the geometrical concentration of 1000x the simulation results show the acceptance angle of +/-1.8 deg. The irradiance distribution on the cell is achieved with ultra-short homogenizing prism, whose size is optimised to keep the maximum values under the ones that the cell can accept. The application of the XR optics to high-concentration is being developed in a consortium leaded by The Boeing Company, which has been awarded a project by US DOE in the framework of the Solar America Initiative.

Lesbian mommy blogging in Canada: documenting subtle homophobia in Canadian society and building community online.

PubMed

Hunter, Andrea

2015-01-01

This article analyzes how lesbian mommy bloggers in Canada are using their blogs as forums for self-expression and a means to form community, as they record their unique experiences as queer parents. Further, it argues that lesbian mommy blogging is documenting a subtle form of homophobia that exists in Canada in terms of social acceptance. Although there is legal acceptance of queer families, society has not necessarily caught up with the law. These blogs show that lesbian parents in Canada still struggle with issues of equality, including difficulties being "out," invisibility, and having to advocate for the non-birth parent.

A comparison of abused and non-abused women's definitions of domestic violence and attitudes to acceptance of male dominance.

PubMed

Faramarzi, M; Esmailzadeh, S; Mosavi, S

2005-10-01

To examine the effects of women's subjective definitions of wife abuse and of their general attitudes to acceptance of male dominance on the occurrence of domestic violence. A case-control survey was conducted in the public health center of Babol University of Medical Sciences from November 2002 to October 2003. The Abuse Assessment Screen Form was used to identify partner violence, and the Abuse Definition Form and Abuse Attitude Form were applied to measure how the women defined wife abuse and their attitudes to male dominance. Women with positive attitudes to male dominance had experienced more physical and emotional abuse than those with negative attitudes toward male dominance (p < 0.05). Although living in villages, low level of education, female unemployment, and low family income were important risk factors for domestic violence, the strongest predictor of physical abuse was a positive attitude to male dominance. A positive attitude of women to male dominance increases the acceptance and frequency of partner violence. This finding shows the need to raise the educational levels of women and raise their awareness of their rights. This could convert an attitude of male dominance to equality of men and women.

76 FR 10387 - Agency Information Collection Activities: Form I-929; Extension of an Existing Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

...: 60-Day Notice of Information Collection Under Review; Form I- 929, Petition for Qualifying Family... will be accepted for sixty days until April 25, 2011. Written comments and/or suggestions regarding the...: Petition for Qualifying Family Member of a U-1 Nonimmigrant. (3) Agency form number, if any, and the...

30 CFR 280.12 - What must I include in my application or notification?

Code of Federal Regulations, 2010 CFR

2010-07-01

... application form (Form MMS-134) at least 30 days before the startup date for activities in the permit area. If... Director to arrange an acceptable deadline. The form includes names of persons; the type, location, purpose... other person(s) participating in the proposed research, including the sponsor; (3) The type of research...

17 CFR 210.11-03 - Presentation of financial forecast.

Code of Federal Regulations, 2010 CFR

2010-04-01

... required by generally accepted accounting principles. Form and Content of Schedules general ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Presentation of financial... FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES ACT OF 1933, SECURITIES...

7 CFR 1755.27 - Borrower contractual obligations.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., DEPARTMENT OF AGRICULTURE TELECOMMUNICATIONS POLICIES ON SPECIFICATIONS, ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.27 Borrower contractual obligations. (a) Loan agreement. As a condition of a loan or... pursuant to which the borrowers agree to use RUS standard contract forms for construction, procurement...

Do dry roasting, lightly salting nuts affect their cardioprotective properties and acceptability?

PubMed

Tey, Siew Ling; Robinson, Terryn; Gray, Andrew R; Chisholm, Alexandra W; Brown, Rachel Clare

2017-04-01

Previous studies have reported improvements in cardiovascular disease (CVD) risk factors with the consumption of raw nuts. However, around one-third of nuts consumed are roasted and salted. Thus, it is important to determine whether roasting and salting nuts affect the health benefits observed with raw nuts. This study aimed to compare the effects of consuming two different forms of hazelnuts on cardiovascular risk factors and acceptance. Using a randomised crossover design, 72 participants were asked to consume 30 g/day of either raw or dry roasted, lightly salted hazelnuts for 28 days each. CVD risk factors were measured at the beginning and end of each treatment period. "Desire to consume" and "overall liking" for both forms of hazelnuts were assessed daily using a 150-mm visual analogue scale. Body composition, blood pressure, plasma total and low-density lipoprotein-cholesterol, apolipoprotein A1 and B100, glucose and α-tocopherol concentrations did not differ between forms of hazelnuts (all P ≥ 0.054). High-density lipoprotein (HDL)-cholesterol (P = 0.037) and triacylglycerol (P < 0.001) concentrations were significantly lower following the consumption of dry roasted, lightly salted hazelnuts when compared to the raw hazelnuts. Compared with baseline, consuming both forms of hazelnuts significantly improved HDL-cholesterol and apolipoprotein A1 concentrations, total-C/HDL-C ratio, and systolic blood pressure without significantly changing body composition. Acceptance ratings did not differ between forms of hazelnuts and remained high throughout the study. Dry roasting and lightly salting nuts do not appear to negate the cardioprotective effects observed with raw nut consumption, and both forms of nuts are resistant to monotony. Public health messages could be extended to include dry roasted and lightly salted nuts as part of a heart healthy diet.

Enzymatic synthesis of polymers containing nicotinamide mononucleotide

NASA Technical Reports Server (NTRS)

Liu, Rihe

1995-01-01

Nicotinamide mononucleoside 5'-diphosphate in its reduced form is an excellent substrate for polynucleotide phosphorylase from Micrococcus luteus both in de novo polymerization reactions and in primer extension reactions. The oxidized form of the diphosphate is a much less efficient substrate; it can be used to extend primers but does not oligomerize in the absence of a primer. The cyanide adduct of the oxidized substrate, like the reduced substrate, polymerizes efficiently. Loss of cyanide yields high molecular weight polymers of the oxidized form. Terminal transferase from calf thymus accepts nicotinamide mononucleoside 5'-triphosphate as a substrate and efficiently adds one residue to the 3'-end of an oligodeoxynucleotide. T4 polynucleotide kinase accepts oligomers of nicotinamide mononucleotide as substrates. However, RNA polymerases do not incorporate nicotinamide mononucleoside 5'-triphosphate into products on any of the templates that we used.

Enzymatic Synthesis of Polymers Containing Nicotinamide Mononucleotide

NASA Technical Reports Server (NTRS)

Liu, Rihe; Orgel, Leslie E.

1995-01-01

Nicotinamide mononucleoside 5'-diphosphate in its reduced form is an excellent substrate for polynucleotide phosphorylase from Micrococcus luteus both in de novo polymerization reactions and in primer extension reactions. The oxidized form of the diphosphate is a much less efficient substrate; it can be used to extend primers but does not oligomerize in the absence of a primer. The cyanide adduct of the oxidized substrate, like the reduced substrate, polymerizes efficiently. Loss of cyanide yields high molecular weight polymers of the oxidized form. Terminal transferase from calf thymus accepts nicotinamide mononucleoside 5'-triphosphate as a substrate and efficiently adds one residue to the 3'-end of an oligodeoxynucleotide. T4 polynucleotide kinase accepts oligomers of nicotinamide mononucleotide as substrates. However, RNA polymerases do not incorporate nicotinamide mononucleoside 5'-triphosphate into products on any of the templates that we used.

Form 2290, heavy highway vehicle use tax, schedule 1 guidance for state motor vehicle licensing offices.

DOT National Transportation Integrated Search

2010-01-01

The purpose of this memorandum is to provide guidance to the state Motor : Vehicle Licensing Offices on acceptable proof of payment regarding Form 2290, : Schedule 1. Please review this material and share it with your employees.

44 CFR 6.30 - Form of requests.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Form of requests. 6.30 Section 6.30 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... manager, at his discretion, may accept oral requests for access subject to verification of identity. ...

Beware Emotional Maltreatment

ERIC Educational Resources Information Center

King, Margaret A.; Janson, Gregory R.

2011-01-01

Emotional maltreatment is a less visible form of abuse that frequently occurs in schools, but is often ignored or dismissed as an acceptable form of discipline or sanctioned classroom-management practice. The impact of emotional maltreatment on children is significant and impacts personality development, relationships, and learning. Principals, as…

21 CFR 1316.94 - Posting of substitute res in an administrative forfeiture action.

Code of Federal Regulations, 2010 CFR

2010-04-01

... particularly suit it for use in illegal activities. This payment must be in the form of a traveler's check, a... bond in the form of a cashier's check will be considered as paid once the check has been accepted for...

21 CFR 1316.94 - Posting of substitute res in an administrative forfeiture action.

Code of Federal Regulations, 2011 CFR

2011-04-01

... particularly suit it for use in illegal activities. This payment must be in the form of a traveler's check, a... bond in the form of a cashier's check will be considered as paid once the check has been accepted for...

21 CFR 1316.94 - Posting of substitute res in an administrative forfeiture action.

Code of Federal Regulations, 2012 CFR

2012-04-01

... particularly suit it for use in illegal activities. This payment must be in the form of a traveler's check, a... bond in the form of a cashier's check will be considered as paid once the check has been accepted for...

12 CFR Appendix H to Part 222 - Appendix H-Model Forms for Risk-Based Pricing and Credit Score Disclosure Exception Notices

Code of Federal Regulations, 2012 CFR

2012-01-01

... appendix are models; their use is optional. 3. A person may change the forms by rearranging the format or... when rearranging the format of the model forms. a. Acceptable changes include, for example: i. Corrections or updates to telephone numbers, mailing addresses, or Web site addresses that may change over...

13 CFR 108.630 - Requirement for NMVC companies to file financial statements and supplementary information with...

Code of Federal Regulations, 2011 CFR

2011-01-01

... before the last day of the fifth month following the end of your fiscal year. (1) Audit of Form 468. An independent public accountant acceptable to SBA must audit the annual Form 468. (2) Insurance requirement for... SBA. (e) Reporting of social, economic, or community development impact information on Form 468. Your...

41 CFR 304-6.9 - Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... or a concurrence by OGE in the agency's conflict of interest analysis? 304-6.9 Section 304-6.9 Public Contracts and Property Management Federal Travel Regulation System PAYMENT OF TRAVEL EXPENSES FROM A NON... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false Does acceptance by OGE...

Assessment of the Prosocial Behaviors of Young Children with Regard to Social Development, Social Skills, Parental Acceptance-Rejection and Peer Relationships

ERIC Educational Resources Information Center

Gulay, Hulya

2011-01-01

The aim of the study was prosocial behaviors of 5-6 years old children were investigated with regard to parental acceptance-rejection, peer relationships, general social development and social skills. The participants of the study included 277 5-6-year-old Turkish children and their parents. The Child Behavior Scale, Social Skills Form, Marmara…

Processes of Change in Acceptance and Commitment Therapy and Cognitive Therapy for Depression: A Mediation Reanalysis of Zettle and Rains

ERIC Educational Resources Information Center

Zettle, Robert D.; Rains, Jeanetta C.; Hayes, Steven C.

2011-01-01

Several articles have recently questioned the distinction between acceptance and commitment therapy (ACT) and traditional cognitive therapy (CT). This study presents a reanalysis of data from Zettle and Rains that compared 12 weeks of group CT with group ACT. For theoretical reasons, Zettle and Rains also included a modified form of CT that did…

The Emergence of a Fourth Type of Public Forum: Is the Quasi-Nonpublic Forum a New Paradigm for Student Free Speech Cases?

ERIC Educational Resources Information Center

Lugg, Elizabeth T.; Paterson, Frances R. A.

This paper is a presentation, in outline form, of the development of the "quasi-nonpublic forum," where cases involving student free speech push the envelope of what is acceptable under Constitutional law and what is appropriate/acceptable student behavior under constraints set by school regulations. Context is set by presenting court…

In the Shadow of the Arch: Safety and Acceptance of Lesbian, Gay, Bisexual, Transgender and Queer Students at the University of Georgia.

ERIC Educational Resources Information Center

Hill, Robert J.; Childers, JoEllen; Childs, Adrian P.; Cowie, Gail; Hatton, Annette; Lewis, Jamie B.; MacNair, Nancy; Oswalt, Sara; Perez, Ruperto M.; Valentine, Thomas

The Campus Climate Research Group at the University of Georgia conducted a survey to explore safety and acceptance issues for lesbian, gay, transgender, and queer (LGBTQ) students at the university. The findings are based on 82 questionnaires returned form 223 surveys distributed to the LGBTQ community in fall 2001. The research results indicate…

76 FR 11806 - Agency Information Collection Activities: Form G-1145, Extension of a Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... notified via e-mail and/or text message on their cell phone that their application or petition has been accepted, they are requested to provide their e-mail address and/or cell phone number on Form G-1145, and...

19 CFR 4.99 - Forms; substitution.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the instructions shall be followed. (c) The port director, in his discretion, may accept a computer printout instead of Customs Form 1302 for use at a specific port. However, to ensure that computer...

19 CFR 4.99 - Forms; substitution.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the instructions shall be followed. (c) The port director, in his discretion, may accept a computer printout instead of Customs Form 1302 for use at a specific port. However, to ensure that computer...

19 CFR 4.99 - Forms; substitution.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the instructions shall be followed. (c) The port director, in his discretion, may accept a computer printout instead of Customs Form 1302 for use at a specific port. However, to ensure that computer...

19 CFR 4.99 - Forms; substitution.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the instructions shall be followed. (c) The port director, in his discretion, may accept a computer printout instead of Customs Form 1302 for use at a specific port. However, to ensure that computer...

19 CFR 4.99 - Forms; substitution.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... the instructions shall be followed. (c) The port director, in his discretion, may accept a computer printout instead of Customs Form 1302 for use at a specific port. However, to ensure that computer...

21 CFR 1316.98 - Substitute res bond in a judicial forfeiture action against a conveyance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... characteristics that particularly suit it for use in illegal activities. This bond must be in the form of a.... A bond in the form of a cashier's check will be considered as paid once the check has been accepted...

21 CFR 1316.98 - Substitute res bond in a judicial forfeiture action against a conveyance.

Code of Federal Regulations, 2012 CFR

2012-04-01

... characteristics that particularly suit it for use in illegal activities. This bond must be in the form of a.... A bond in the form of a cashier's check will be considered as paid once the check has been accepted...

21 CFR 1316.98 - Substitute res bond in a judicial forfeiture action against a conveyance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... characteristics that particularly suit it for use in illegal activities. This bond must be in the form of a.... A bond in the form of a cashier's check will be considered as paid once the check has been accepted...

Acceptance and Avoidance Processes at Different Levels of Psychological Recovery from Enduring Mental Illness.

PubMed

Siqueira, Vinicius R; Oades, Lindsay G

2015-01-01

Objective. This study examined the use of psychological acceptance and experiential avoidance, two key concepts of Acceptance and Commitment Therapy (ACT), in the psychological recovery process of people with enduring mental illness. Method. Sixty-seven participants were recruited from the metropolitan, regional, and rural areas of New South Wales, Australia. They all presented some form of chronic mental illness (at least 12 months) as reflected in DSM-IV Axis I diagnostic criteria. The Acceptance and Action Questionnaire (AAQ-19) was used to measure the presence of psychological acceptance and experiential avoidance; the Recovery Assessment Scale (RAS) was used to examine the levels of psychological recovery; and the Scales of Psychological Well-Being was used to observe if there are benefits in utilizing psychological acceptance and experiential avoidance in the recovery process. Results. An analysis of objectively quantifiable measures found no clear correlation between the use of psychological acceptance and recovery in mental illness as measured by the RAS. The data, however, showed a relationship between psychological acceptance and some components of recovery, thereby demonstrating its possible value in the recovery process. Conclusion. The major contribution of this research was the emerging correlation that was observed between psychological acceptance and positive levels of psychological well-being among individuals with mental illness.

Historical Trends in Graduate Research and Training of Diplomates of the American Board of Forensic Anthropology.

PubMed

Bethard, Jonathan D

2017-01-01

The history of forensic anthropology has been documented by numerous scholars. These contributions have described the work of early pioneers in the field and have described important milestones, such as the founding of the Physical Anthropology Section of the American Academy of Forensic Sciences (AAFS) in 1972 and the American Board of Forensic Anthropology (ABFA) in 1977. This paper contributes to the growing literature on the history of forensic anthropology by documenting the academic training of all individuals who have been granted diplomate status by the ABFA (n = 115). Doctoral dissertation titles were queried to discern broad patterns of research foci. A total of 39 doctoral granting institutions have trained diplomates and 77.3% of board-certified forensic anthropologists wrote dissertations involving skeletal biology, bioarchaeology, or forensic anthropology. Board-certified forensic anthropologists are a broadly trained group of professionals with far-reaching anthropological interests and expertise. © 2016 American Academy of Forensic Sciences.

Biomass Burning Observation Project (BBOP) Final Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kleinman, LI; Sedlacek, A. J.

2016-01-01

The Biomass Burning Observation Project (BBOP) was conducted to obtain a better understanding of how aerosols generated from biomass fires affect the atmosphere and climate. It is estimated that 40% of carbonaceous aerosol produced originates from biomass burning—enough to affect regional and global climate. Several biomass-burning studies have focused on tropical climates; however, few campaigns have been conducted within the United States, where millions of acres are burned each year, trending to higher values and greater climate impacts because of droughts in the West. Using the Atmospheric Radiation Measurement (ARM) Aerial Facility (AAF), the BBOP deployed the Gulfstream-1 (G-1) aircraftmore » over smoke plumes from active wildfire and agricultural burns to help identify the impact of these events and how impacts evolve with time. BBOP was one of very few studies that targeted the near-field time evolution of aerosols and aimed to obtain a process-level understanding of the large changes that occur within a few hours of atmospheric processing.« less

Campaign datasets for ARM Cloud Aerosol Precipitation Experiment (ACAPEX)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leung, L. Ruby; Mei, Fan; Comstock, Jennifer

This campaign consisted of the deployment of the DOE ARM Mobile Facility 2 (AMF2) and the ARM Aerial Facility (AAF) G-1 in a field campaign called ARM Cloud Aerosol Precipitation Experiment (ACAPEX), which took place in conjunction with CalWater 2- a NOAA field campaign. The joint CalWater 2/ACAPEX field campaign aimed to improve understanding and modeling of large-scale dynamics and cloud and precipitation processes associated with ARs and aerosol-cloud interactions that influence precipitation variability and extremes in the western U.S. The observational strategy consisted of the use of land and offshore assets to monitor: 1. the evolution and structure ofmore » ARs from near their regions of development 2. the long-range transport of aerosols in the eastern North Pacific and potential interactions with ARs 3. how aerosols from long-range transport and local sources influence cloud and precipitation in the U.S. West Coast where ARs make landfall and post-frontal clouds are frequent.« less

2011 lAAF World Championships in Daegu: blood tests for all athletes in the framework of the Athlete Biological Passport.

PubMed

Robinson, Neil; Dollé, Gabriel; Garnier, Pierre-Yves; Saugy, Martial

2012-07-01

The 2011 International Association of Athletics Federation (IAAF) World Championships took place in Daegu, Korea. For the first time, all athletes were blood tested prior to the competition in order to give a clear signal to the world athletic community of the wish to enter into the era of the Athlete Biological Passport and fight against doping in their sport. The hematological parameters were measured on site. Thus, a mobile-accredited laboratory for blood testing was created in Daegu. Two serum tubes were collected for clinical chemistry and hormonal analyses in order to build the bases of the endocrine and the androgen (steroid) modules of the Athlete Biological Passport in blood. This paper describes some of the main challenges the project faced with regard to the large number of athletes, competing in different disciplines, and the logistic problems that had to be solved for smart implementation of one of the most complex operations organized in the last decade in the fight against doping.

Precipitation and Hydrology Experiment Counter-Flow Spectrometer and Impactor Field Campaign Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poellot, Michael

The U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility Aerial Facility (ARM AAF) counter-flow spectrometer and impactor (CSI) probe was flown on the University of North Dakota Cessna Citation research aircraft during the Integrated Precipitation and Hydrology Experiment (IPHEX). The field campaign took place during May and June of 2014 over North Carolina and its coastal waters as part of a National Aeronautics and Space Administration (NASA) Global Precipitation Measurement validation campaign. The CSI was added to the Citation instrument suite to support the involvement of Jay Mace through the NASA Advanced Composition Explorer (ACE) satellitemore » program and flights of the NASA ER-2 aircraft, which is a civilian version of the Air Force’s U2-S reconnaissance platform. The ACE program funded extra ER-2 flights to focus on clouds that are weakly precipitating, which are also of interest to the Atmospheric System Research program sponsored by DOE.« less

Bad Tolz AAF, Bad Tolz, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1972-01-26

3.9 23 s.4 #1i 0.Q So. I__I- _ W 1,7. 4. 4. 4 -jIj6 -j2 9so ___ 12#? i7 WN & ,7 1 3 I0 to 5 5 8, WNW ISO . .3L .54L al 1 * .1 A.10 4-q 4,___- NNW 06 _0_...146.5 46.3 46.7 46.7 46.7 46.7l 46,9; 4701 2:ooo [42#2 465. 41 46iY 3 46934f 46,91 471 47,_ ___ 7,5 4 4 7 1 27000 ?__ 961 50PI KP3 5o, 5G5 500 50...34ou.g0v : Q3e3 00# 00000~ ~ 00 o 0 Col 00,0 , 00 0 ~0000 Iso a00 733gog 913S Coto0, 0 0 00,0 00,0 00#0 009000top900,0 00 00,0 00,0 12_ 0 )00 7# gg13

Fort Knox/Godman AAF, Kentucky. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1982-07-13

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Letter Report: LAW Simulant Development for Cast Stone Screening Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russell, Renee L.; Westsik, Joseph H.; Swanberg, David J.

2013-03-27

More than 56 million gallons of radioactive and hazardous waste are stored in 177 underground storage tanks at the U.S. Department of Energy’s (DOE’s) Hanford Site in southeastern Washington State. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is being constructed to treat the wastes and immobilize them in a glass waste form. The WTP includes a pretreatment facility to separate the wastes into a small volume of high-level waste (HLW) containing most of the radioactivity and a larger volume of low-activity waste (LAW) containing most of the nonradioactive chemicals. The HLW will be converted to glass in themore » HLW vitrification facility for ultimate disposal at an offsite federal repository. At least a portion (~35%) of the LAW will be converted to glass in the LAW vitrification facility and will be disposed of onsite at the Integrated Disposal Facility (IDF). The pretreatment and HLW vitrification facilities will have the capacity to treat and immobilize the wastes destined for each facility. However, a second facility will be needed for the expected volume of additional LAW requiring immobilization. A cementitious waste form known as Cast Stone is being considered to provide the required additional LAW immobilization capacity. The Cast Stone waste form must be acceptable for disposal in the IDF. The Cast Stone waste form and immobilization process must be tested to demonstrate that the final Cast Stone waste form can comply with waste acceptance criteria for the IDF disposal facility and that the immobilization processes can be controlled to consistently provide an acceptable waste form product. Further, the waste form must be tested to provide the technical basis for understanding the long term performance of the waste form in the IDF disposal environment. These waste form performance data are needed to support risk assessment and performance assessment (PA) analyses of the long-term environmental impact of the waste disposal in the IDF. A testing program was developed in fiscal year (FY) 2012 describing in some detail the work needed to develop and qualify Cast Stone as a waste form for the solidification of Hanford LAW (Westsik et al. 2012). Included within Westsik et al. (2012) is a section on the near-term needs to address Tri-Party Agreement Milestone M-062-40ZZ. The objectives of the testing program to be conducted in FY 2013 and FY 2014 are to: • Determine an acceptable formulation for the LAW Cast Stone waste form. • Evaluate sources of dry materials for preparing the LAW Cast Stone. • Demonstrate the robustness of the Cast Stone waste form for a range of LAW compositions. • Demonstrate the robustness of the formulation for variability in the Cast Stone process. • Provide Cast Stone contaminant release data for PA and risk assessment evaluations. The first step in determining an acceptable formulation for the LAW Cast Stone waste form is to conduct screening tests to examine expected ranges in pretreated LAW composition, waste stream concentrations, dry-materials sources, and mix ratios of waste feed to dry blend. A statistically designed test matrix will be used to evaluate the effects of these key parameters on the properties of the Cast Stone as it is initially prepared and after curing. The second phase of testing will focus on selection of a baseline Cast Stone formulation for LAW and demonstrating that Cast Stone can meet expected waste form requirements for disposal in the IDF. It is expected that this testing will use the results of the screening tests to define a smaller suite of tests to refine the composition of the baseline Cast Stone formulation (e.g. waste concentration, water to dry mix ratio, waste loading).« less

Market Segmentation in Higher Education: A Case Study.

ERIC Educational Resources Information Center

Muffo, John A.

1987-01-01

A survey of applicants accepted by a major research university found that among the most sought-after applicants, academic scholarships and other forms of forms of financial aid were more likely to have influenced college choice, putting the institution with minimal non-need-based financial aid at a competitive disadvantage. (MSE)

7 CFR Appendix A to Subpart B of... - Review Rating Summary, RUS Form 300

Code of Federal Regulations, 2014 CFR

2014-01-01

.... System Load Conditions and Losses a. Annual System Loses, ____%—Rating:____ b. Annual Load Factor... ____ Date Prepared ____ Ratings on form are: 0: Unsatisfactory—no records 1: Unsatisfactory—corrective action needed 2: Acceptable, but should be improved—see attached recommendations 3: Satisfactory—no...

Coupling Social Solidarity and Social Harmony in Hong Kong

ERIC Educational Resources Information Center

Cheung, Chau-kiu; Ma, Stephen Kan

2011-01-01

The various forms of social solidarity are empirically uncharted, especially in relation to social harmony. With respect to resource exchange theory, inclusive solidarity or intergroup acceptance is more conducive to social harmony than mechanical, organic, distributive, and dialogic forms of solidarity. The theoretical prediction holds in the…

Proton Form Factor Puzzle and the CEBAF Large Acceptance Spectrometer (CLAS) Two-Photon Exchange Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rimal, Dipak

2014-05-01

The electromagnetic form factors are the most fundamental observables that encode information about the internal structure of the nucleon. This dissertation explored dependence of R on kinematic variables such as squared four-momentum transfer (Q 2) and the virtual photon polarization parameter (ε).

Nontraditional Family Forms: A Decade of Research.

ERIC Educational Resources Information Center

Macklin, Eleanor D.

1980-01-01

Nontraditional forms which have shown the largest increase in the 70s are those resulting from divorce, dual-work and dual-career families, single-person households, and couples living together. Lifestyles reflect acceptance of nonmarital sexuality, growing freedom from traditional roles and expectations, and greater equality between men and…

12 CFR Appendix H to Part 1022 - Appendix H-Model Forms for Risk-Based Pricing and Credit Score Disclosure Exception Notices

Code of Federal Regulations, 2013 CFR

2013-01-01

... addresses that may change over time. ii. The addition of graphics or icons, such as the person's corporate... change the forms by rearranging the format or by making technical modifications to the language of the... required to conduct consumer testing when rearranging the format of the model forms. a. Acceptable changes...

12 CFR Appendix H to Part 222 - Appendix H-Model Forms for Risk-Based Pricing and Credit Score Disclosure Exception Notices

Code of Federal Regulations, 2014 CFR

2014-01-01

... addresses that may change over time. ii. The addition of graphics or icons, such as the person's corporate... rate. All forms contained in this appendix are models; their use is optional. 3. A person may change... required to conduct consumer testing when rearranging the format of the model forms. a. Acceptable changes...

Impact of evergreening on patients and health insurance: a meta analysis and reimbursement cost analysis of citalopram/escitalopram antidepressants

PubMed Central

2012-01-01

Background "Evergreening" refers to the numerous strategies whereby owners of pharmaceutical products use patent laws and minor drug modifications to extend their monopoly privileges on the drug. We aimed to evaluate the impact of evergreening through the case study of the antidepressant citalopram and its chiral switch form escitalopram by evaluating treatment efficacy and acceptability for patients, as well as health insurance costs for society. Methods To assess efficacy and acceptability, we performed meta-analyses for efficacy and acceptability. We compared direct evidence (meta-analysis of results of head-to-head trials) and indirect evidence (adjusted indirect comparison of results of placebo-controlled trials). To assess health insurance costs, we analyzed individual reimbursement data from a representative sample of the French National Health Insurance Inter-regime Information System (SNIIR-AM) from 2003 to 2010, which allowed for projecting these results to the whole SNIIR-AM population (53 million people). Results In the meta-analysis of seven head-to-head trials (2,174 patients), efficacy was significantly better for escitalopram than citalopram (combined odds ratio (OR) 1.60 (95% confidence interval 1.05 to 2.46)). However, for the adjusted indirect comparison of 10 citalopram and 12 escitalopram placebo-controlled trials, 2,984 and 3,777 patients respectively, efficacy was similar for the two drug forms (combined indirect OR 1.03 (0.82 to 1.30)). Because of the discrepancy, we could not combine direct and indirect data (test of inconsistency, P = 0.07). A similar discrepancy was found for treatment acceptability. The overall reimbursement cost burden for the citalopram, escitalopram and its generic forms was 120.6 million Euros in 2010, with 96.8 million Euros for escitalopram. Conclusions The clinical benefit of escitalopram versus citalopram remains uncertain. In our case of evergreening, escitalopram represented a substantially high proportion of the overall reimbursement cost burden as compared with citalopram and the generic forms. PMID:23167972

Impact of evergreening on patients and health insurance: a meta analysis and reimbursement cost analysis of citalopram/escitalopram antidepressants.

PubMed

Alkhafaji, Ali A; Trinquart, Ludovic; Baron, Gabriel; Desvarieux, Moïse; Ravaud, Philippe

2012-11-20

"Evergreening" refers to the numerous strategies whereby owners of pharmaceutical products use patent laws and minor drug modifications to extend their monopoly privileges on the drug. We aimed to evaluate the impact of evergreening through the case study of the antidepressant citalopram and its chiral switch form escitalopram by evaluating treatment efficacy and acceptability for patients, as well as health insurance costs for society. To assess efficacy and acceptability, we performed meta-analyses for efficacy and acceptability. We compared direct evidence (meta-analysis of results of head-to-head trials) and indirect evidence (adjusted indirect comparison of results of placebo-controlled trials). To assess health insurance costs, we analyzed individual reimbursement data from a representative sample of the French National Health Insurance Inter-regime Information System (SNIIR-AM) from 2003 to 2010, which allowed for projecting these results to the whole SNIIR-AM population (53 million people). In the meta-analysis of seven head-to-head trials (2,174 patients), efficacy was significantly better for escitalopram than citalopram (combined odds ratio (OR) 1.60 (95% confidence interval 1.05 to 2.46)). However, for the adjusted indirect comparison of 10 citalopram and 12 escitalopram placebo-controlled trials, 2,984 and 3,777 patients respectively, efficacy was similar for the two drug forms (combined indirect OR 1.03 (0.82 to 1.30)). Because of the discrepancy, we could not combine direct and indirect data (test of inconsistency, P = 0.07). A similar discrepancy was found for treatment acceptability. The overall reimbursement cost burden for the citalopram, escitalopram and its generic forms was 120.6 million Euros in 2010, with 96.8 million Euros for escitalopram. The clinical benefit of escitalopram versus citalopram remains uncertain. In our case of evergreening, escitalopram represented a substantially high proportion of the overall reimbursement cost burden as compared with citalopram and the generic forms.

41 CFR 304-6.9 - Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... or a concurrence by OGE in the agency's conflict of interest analysis? 304-6.9 Section 304-6.9 Public...-FEDERAL SOURCE AGENCY REQUIREMENTS 6-PAYMENT GUIDELINES Valuation § 304-6.9 Does acceptance by OGE of the... concurrence by OGE in the agency's conflict of interest analysis? No. OGE is responsible for making the...

Apollo experience report the command and service module milestone review process

NASA Technical Reports Server (NTRS)

Brendle, H. L.; York, J. A.

1974-01-01

The sequence of the command and service module milestone review process is given, and the Customer Acceptance Readiness Review and Flight Readiness Review plans are presented. Contents of the System Summary Acceptance Documents for the two formal spacecraft reviews are detailed, and supplemental data required for presentation to the review boards are listed. Typical forms, correspondence, supporting documentation, and minutes of a board meeting are included.

Hydrogeology Journal in 2004

USGS Publications Warehouse

Voss, Clifford; Olcott, Perry; Schneider, Robert; Watson, Christine

2004-01-01

Hydrogeology Journal continues to flourish. The increase in the size of our yearly volume attests to the success and growing international reputation of the journal. Until 2001, HJ produced about 600 printed pages each year. This number has steadily increased, and in 2005 and 2006, HJ will be allocated 800 pages per year by the publisher. Despite this good news, the journal is having some growing pains. Most pages in next year’s issues are already fully allocated with currently accepted articles and therefore, many accepted articles must now wait up to one year to appear in printed form. Clearly, this is not an acceptable situation for authors or readers.

Ethics of pharmaceutical company relationships with the nursing profession: no free lunch...and no more pens?

PubMed

Crock, Elizabeth

2009-10-01

In recent years, nurses have increasingly become recipients of pharmaceutical company gifts, funding and sponsorship. There has been little discussion in the nursing literature, however, of the ethical and professional implications of nurses' acceptance of such sponsorship. This article examines ethical issues related to the issue of nurses' accepting benefits from pharmaceutical companies (and other commercial enterprises). It aims to encourage nurses to look critically at the implications of accepting such gifts/sponsorship, or to enter any form of relationship with commercial companies within the health sector, and to stimulate further discussion of this issue within the profession.

Stratigraphy and Surface Ages of Dwarf Planet (1) Ceres: Results from Geologic and Topographic Mapping in Survey, HAMO and LAMO Data of the Dawn Framing Camera Images

NASA Astrophysics Data System (ADS)

Wagner, R. J.; Schmedemann, N.; Stephan, K.; Jaumann, R.; Neesemann, A.; Preusker, F.; Kersten, E.; Roatsch, T.; Hiesinger, H.; Williams, D. A.; Yingst, R. A.; Crown, D. A.; Mest, S. C.; Raymond, C. A.; Russell, C. T.

2017-12-01

Since March 6, 2015, the surface of dwarf planet (1) Ceres is being imaged by the FC framing camera aboard the Dawn spacecraft from orbit at various altitudes [1]. For this study we focus on images from the Survey orbit phase (4424 km altitude) with spatial resolutions of 400 m/pxl and use images and topographic data from DTMs (digital terrain models) for global geologic mapping. On Ceres' surface cratered plains are ubiquitous, with variations in superimposed crater frequency indicating different ages and processes. Here, we take the topography into account for geologic mapping and discriminate cratered plains units according to their topographic level - high-standing, medium, or low-lying - in order to examine a possible correlation between topography and surface age. Absolute model ages (AMAs) are derived from two impact cratering chronology models discussed in detail by [2] (henceforth termed LDM: lunar-derived model, and ADM: asteroid-derived model). We also apply an improved method to obtain relative ages and AMAs from crater frequency measurements termed Poisson timing analysis [3]. Our ongoing analysis shows no trend that the topographic level has an influence on the age of the geologic units. Both high-standing and low-lying cratered plains have AMAs ranging from 3.5 to 1.5 Ga (LDM), versus 4.2 to 0.5 Ga (ADM). Some areas of measurement within these units, however, show effects of resurfacing processes in their crater distributions and feature an older and a younger age. We use LAMO data (altitude: 375 km; resolution 30 m/pxl) and/or HAMO data (altitude: 1475 km; resolution 140 m/pxl) to study local geologic units and their ages, e.g., smaller impact craters, especially those not dated so far with crater measurements and/or those with specific spectral properties [4], deposits of mass wasting (e.g., landslides), and mountains, such as Ahuna Mons. Crater frequencies are used to set these geologic units into the context of Ceres' time-stratigraphic system and chronologic periods [5]. References: [1] Russell C. T., et al. (2016), Science 353, doi:10.1126/science.aaf4219. [2] Hiesinger H. H. et al. (2016), Science 353, doi:10.1126/science.aaf4759. [3] Michael G. G. et al. (2016), Icarus 277, 279-285. [4] Stephan K. et al. (2017), submitted to Icarus. [5] Mest S. C. et al. (2017), LPSC XLVIII, abstr. No. 2512.

Physical punishment of children: can we continue to accept the status quo?

PubMed

Oates, Kim

2011-08-01

All children require discipline, although physical punishment is just one form of discipline. Parental use of physical punishment is inter-generational. There is now evidence that physical punishment of children is not only less effective than other forms of discipline but can also lead to aggressive behaviour in childhood and adult life. Twenty-nine countries, including New Zealand, have laws against physical punishment in the home. Australian attitudes are slowly changing in favour of less use of physical punishment, but there is a long way to go. As advocates for children, paediatricians should not be content to accept the status quo. © 2011 The Author. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

31 CFR 128.2 - Manner of reporting.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (a) Methods of reporting—(1) Prescribed forms. (i) Except as provided in § 128.2(a)(2), reports... 20220. (2) Alternative methods of reporting. In lieu of reporting on forms prescribed by the Secretary pursuant to this part, reports may be filed on magnetic tape or other media acceptable to, and approved in...

Strategies for Ensuring Trustworthiness in Qualitative Research Projects

ERIC Educational Resources Information Center

Shenton, Andrew K.

2004-01-01

Although many critics are reluctant to accept the trustworthiness of qualitative research, frameworks for ensuring rigour in this form of work have been in existence for many years. Guba's constructs, in particular, have won considerable favour and form the focus of this paper. Here researchers seek to satisfy four criteria. In addressing…

Advances in Planetary Geology

NASA Technical Reports Server (NTRS)

Woronow, A. (Editor)

1982-01-01

Advances in Planetary Geology is a new series intended to serve the planetary geology community with a form for quick and thorough communications. There are no set lists of acceptable topics or formats, and submitted manuscripts will not undergo a formal review. All submissions should be in a camera ready form, preferably spaced, and submitted to the editor.

Isolated and Integrated Form-Focused Instruction from Learners' Perspective

ERIC Educational Resources Information Center

Ansarin, Ali Akbar; Arasteh Abbas Abad, Behnam; Banan Khojasteh, Mohammad Reza

2015-01-01

In place of categorical hypotheses for rejection or acceptance of isolated or integrated form-focused instruction (FFI) in (quasi) experimental studies, this survey was intended to gauge the complementary versus competing nature of isolated and integrated FFI from learners' perspective. The impetus behind this study was the overwhelming lack of…

Reactions to Discrimination, Stigmatization, Ostracism, and Other Forms of Interpersonal Rejection: A Multimotive Model

ERIC Educational Resources Information Center

Richman, Laura Smart; Leary, Mark R.

2009-01-01

This article describes a new model that provides a framework for understanding people's reactions to threats to social acceptance and belonging as they occur in the context of diverse phenomena such as rejection, discrimination, ostracism, betrayal, and stigmatization. People's immediate reactions are quite similar across different forms of…

Maleficent Reborn: Disney's Fairytale View of Gender Reaches Puberty

ERIC Educational Resources Information Center

Justice, Benjamin

2014-01-01

Fairy tales--indeed all tales--are told for a purpose. They are a form of social education, a form that some scholars argue is older than civilization itself. They imagine dilemmas and offer a range of permissible solutions, labeling socially acceptable and unacceptable behavior, demarcating good and evil, exploring existential questions, binding…

MASH test 3-11 of the TxDOT single slope bridge rail (type SSTR) on pan-formed bridge deck

DOT National Transportation Integrated Search

2011-03-01

The objective of this crash test was to determine whether the TxDOT Single Slope Traffic Rail (Type : SSTR) would perform acceptably on a pan-formed deck when tested according to the guidelines set forth in : Manual for Assessing Safety Hardware (MAS...

Secondary Waste Form Screening Test Results—THOR® Fluidized Bed Steam Reforming Product in a Geopolymer Matrix

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pires, Richard P.; Westsik, Joseph H.; Serne, R. Jeffrey

2011-07-14

Screening tests are being conducted to evaluate waste forms for immobilizing secondary liquid wastes from the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Plans are underway to add a stabilization treatment unit to the Effluent Treatment Facility to provide the needed capacity for treating these wastes from WTP. The current baseline is to use a Cast Stone cementitious waste form to solidify the wastes. Through a literature survey, DuraLith alkali-aluminosilicate geopolymer, fluidized-bed steam reformation (FBSR) granular product encapsulated in a geopolymer matrix, and a Ceramicrete phosphate-bonded ceramic were identified both as candidate waste forms and alternatives to the baseline.more » These waste forms have been shown to meet waste disposal acceptance criteria, including compressive strength and universal treatment standards for Resource Conservation and Recovery Act (RCRA) metals (as measured by the toxicity characteristic leaching procedure [TCLP]). Thus, these non-cementitious waste forms should also be acceptable for land disposal. Information is needed on all four waste forms with respect to their capability to minimize the release of technetium. Technetium is a radionuclide predicted to be in the secondary liquid wastes in small quantities, but the Integrated Disposal Facility (IDF) risk assessment analyses show that technetium, even at low mass, produces the largest contribution to the estimated IDF disposal impacts to groundwater.« less

Supplemental Immobilization of Hanford Low-Activity Waste: Cast Stone Screening Tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westsik, Joseph H.; Piepel, Gregory F.; Lindberg, Michael J.

2013-09-30

More than 56 million gallons of radioactive and hazardous waste are stored in 177 underground storage tanks at the U.S. Department of Energy’s (DOE’s) Hanford Site in southeastern Washington State. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is being constructed to treat the wastes and immobilize them in a glass waste form. The WTP includes a pretreatment facility to separate the wastes into a small volume of high-level waste (HLW) containing most of the radioactivity and a larger volume of low-activity waste (LAW) containing most of the nonradioactive chemicals. The HLW will be converted to glass in themore » HLW vitrification facility for ultimate disposal at an offsite federal repository. At least a portion (~35%) of the LAW will be converted to glass in the LAW vitrification facility and will be disposed of onsite at the Integrated Disposal Facility (IDF). The pretreatment and HLW vitrification facilities will have the capacity to treat and immobilize the wastes destined for each facility. However, a second LAW immobilization facility will be needed for the expected volume of LAW requiring immobilization. A cementitious waste form known as Cast Stone is being considered to provide the required additional LAW immobilization capacity. The Cast Stone waste form must be acceptable for disposal in the IDF. The Cast Stone waste form and immobilization process must be tested to demonstrate that the final Cast Stone waste form can comply with the waste acceptance criteria for the disposal facility and that the immobilization processes can be controlled to consistently provide an acceptable waste form product. Further, the waste form must be tested to provide the technical basis for understanding the long-term performance of the waste form in the disposal environment. These waste form performance data are needed to support risk assessment and performance assessment (PA) analyses of the long-term environmental impact of the waste disposal in the IDF. The PA is needed to satisfy both Washington State IDF Permit and DOE Order requirements. Cast Stone has been selected for solidification of radioactive wastes including WTP aqueous secondary wastes treated at the Effluent Treatment Facility (ETF) at Hanford. A similar waste form called Saltstone is used at the Savannah River Site (SRS) to solidify its LAW tank wastes.« less

Acceptability and usability of a telepresence robot for geriatric primary care: A pilot.

PubMed

Vermeersch, Patricia; Sampsel, Debi D; Kleman, Carolyn

2015-01-01

The dual challenge of increasing numbers of older adults and overall increases in those with some form of insurance is driving the need to develop and evaluate novel methods of primary care delivery such as telehealth. The goal of this study was to explore the acceptability and usability of a remote presence robot (RPR) in a simulated primary care wellness encounter for older adults. A descriptive exploratory study was used to determine the acceptability and usability of the RPR operated by an APRN 250 miles from 13 older adults residing in a high rise during a simulated primary care visit. The results support previous research that technology such as the RPR can be both acceptable and useful for an older adult and primary care provider but only in certain circumstances. Copyright © 2015 Elsevier Inc. All rights reserved.

P-Care BPJS Acceptance Model in Primary Health Centers.

PubMed

Markam, Hosizah

2017-01-01

Electronic Medical Records (EMR) are increasingly adopted in healthcare facilities. Recently, implementation failure of electronic information systems is known to be caused by not only the quality of technical aspects, but also the user's behavior. It is known as applying the Technology Acceptance Model (TAM). This research aimed to analyze the acceptance model of p-care BPJS in the primary health centers. A total sample of 30 p-care BPJS users was drawn by multistage random sampling in which of these 30 primary health centers participated. Data analysis used both descriptive and inferential statistics. In the phase of structural model, it indicated that p-care BPJS acceptance model in the primary health centers was formed by Perceived Ease of Use (PEOU) and Perceived Usefulness (PU) through Attitude towards use of p-care BPJS and Behavioral Intention to use p-care BPJS.

A survey of physicians' acceptance of telemedicine.

PubMed

Sheng, O R; Hu, P J; Chau, P Y; Hjelm, N M; Tam, K Y; Wei, C P; Tse, J

1998-01-01

Physicians' acceptance of telemedicine is an important managerial issue facing health-care organizations that have adopted, or are about to adopt, telemedicine. Most previous investigations of the acceptance of telemedicine have lacked theoretical foundation and been of limited scope. We examined technology acceptance and usage among physicians and specialists from 49 clinical departments at eight public tertiary hospitals in Hong Kong. Out of the 1021 questionnaires distributed, 310 were completed and returned, a 30% response rate. The preliminary findings suggested that use of telemedicine among clinicians in Hong Kong was moderate. While 18% of the respondents were using some form of telemedicine for patient care and management, it accounted for only 6.3% of the services provided. The intensity of their technology usage was also low, accounting for only 6.8% of a typical telemedicine-assisted service. These preliminary findings have managerial implications.

Perceptions and attitude effects on nanotechnology acceptance: an exploratory framework

NASA Astrophysics Data System (ADS)

Ganesh Pillai, Rajani; Bezbaruah, Achintya N.

2017-02-01

Existing literature in people's attitude toward nanotechnology and acceptance of nanotechnology applications has generally investigated the impact of factors at the individual or context levels. While this vast body of research is very informative, a comprehensive understanding of how attitude toward nanotechnology are formed and factors influencing the acceptance of nanotechnology are elusive. This paper proposes an exploratory nanotechnology perception-attitude-acceptance framework (Nano-PAAF) to build a systematic understanding of the phenomenon. The framework proposes that perceptions of risks and benefits of nanotechnology are influenced by cognitive, affective, and sociocultural factors. The sociodemographic factors of consumers and contextual factors mitigate the influence of cognitive, affective, and sociocultural factors on the perception of risks and benefits. The perceived risks and benefits in turn influence people's attitude toward nanotechnology, which then influences acceptance of nanotechnology products. This framework will need further development over time to incorporate emerging knowledge and is expected to be useful for researchers, decision and policy makers, industry, and business entities.

Sexual and Reproductive Health Education Needs, Gender Roles Attitudes and Acceptance of Couple Violence According to Engaged Men and Women.

PubMed

Terzioglu, Fusun; Kok, Gulsah; Guvenc, Gulten; Ozdemir, Funda; Gonenc, Ilknur Munevver; Hicyilmaz, Basak Demirtas; Sezer, Neslihan Yılmaz

2018-04-01

This descriptive study was aimed to evaluate the attitudes of the engaged men and women who are of legal age to marry towards gender roles and acceptance of couple violence, and determine their sexual/reproductive health education needs. It was conducted in two marriage registry offices in Ankara, Turkey. The study sample consisted of 740 participants. Data were collected by using semi-structured form, Gender Roles Attitude Scale and Acceptance of Couple Violence Scale. It was found that the engaged couples had educational needs concerning sexual/reproductive health; socio-demographic characteristics such as gender, age, education, residence, and income level created significant differences in the attitudes related to accepting gender roles and violence; and having an egalitarian attitude towards gender roles decreased the rate of accepting violence between the couples. Results indicate that premarital counseling is a promising strategy to support engaged couples' sexual/reproductive health needs, and increase their awareness about gender based couple violence in communities.

Self-reported financial conflicts of interest during scientific presentations in emergency medicine.

PubMed

Birkhahn, Robert H; Fromm, Christian; Larabee, Todd; Diercks, Deborah B

2011-09-01

This study was a review of the scientific abstracts presented at a national conference for the required conflict of interest (COI) disclosure both before the meeting and during presentation. All presenters were given specific instructions regarding COI reporting at the time of abstract acceptance. All poster presentations were required to have a COI statement. Three physicians using standardized data abstraction forms reviewed abstracts accepted for poster presentation at the 2010 annual meeting of the Society for Academic Emergency Medicine (SAEM). Posters were reviewed for the presence of a required COI disclosure statement, and these results were compared to the mandatory continuing medical education (CME) disclosure form that was sent by the presenters to the SAEM central office before the meeting. There were 412 posters accepted for presentation at the 2010 SAEM annual meeting. The reviewers observed 382 (93%) of the total posters for the conference. Sixty-nine abstracts (18%) reported a COI. Only 26 (38%) of these were actually reported to the SAEM office on the CME disclosure form before the meeting; the remaining 62% were found on the poster alone. COI that were reported on the CME disclosure form were found on the poster 46% of the time. The remaining posters without a COI actually displayed the mandatory disclosure statement only 14% of the time. This review of presentations at a national meeting found a lack of compliance with printed guidelines for COI disclosure during scientific presentation. Efforts to increase uniformity and clarity may result in increased compliance. © 2011 by the Society for Academic Emergency Medicine.

14 CFR 35.24 - Strength.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: PROPELLERS Design and Construction § 35.24 Strength. The maximum stresses developed in the propeller may not exceed values acceptable to the Administrator considering the particular form of...

Effects Of Navy Energy Goals On The Navy Shore Energy Programs

DTIC Science & Technology

2017-12-01

release. Distribution is unlimited. THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704–0188 Public reporting...Unclassified 20. LIMITATION OF ABSTRACT UU NSN 7540-01-280-5500 Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. 239-18 ii THIS PAGE...construction and any equipment necessary for an acceptable product. In general, specifications are in the form of written descriptions, drawings, prints