Science.gov

Sample records for accepted standard method

  1. Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods.

    PubMed

    Shanks, Orin C; Kelty, Catherine A; Oshiro, Robin; Haugland, Richard A; Madi, Tania; Brooks, Lauren; Field, Katharine G; Sivaganesan, Mano

    2016-05-01

    There is growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data quality across laboratories. Data quality is typically determined through a series of specifications that ensure good experimental practice and the absence of bias in the results due to DNA isolation and amplification interferences. However, there is currently a lack of consensus on how best to evaluate and interpret human fecal source identification qPCR experiments. This is, in part, due to the lack of standardized protocols and information on interlaboratory variability under conditions for data acceptance. The aim of this study is to provide users and reviewers with a complete series of conditions for data acceptance derived from a multiple laboratory data set using standardized procedures. To establish these benchmarks, data from HF183/BacR287 and HumM2 human-associated qPCR methods were generated across 14 laboratories. Each laboratory followed a standardized protocol utilizing the same lot of reference DNA materials, DNA isolation kits, amplification reagents, and test samples to generate comparable data. After removal of outliers, a nested analysis of variance (ANOVA) was used to establish proficiency metrics that include lab-to-lab, replicate testing within a lab, and random error for amplification inhibition and sample processing controls. Other data acceptance measurements included extraneous DNA contamination assessments (no-template and extraction blank controls) and calibration model performance (correlation coefficient, amplification efficiency, and lower limit of quantification). To demonstrate the implementation of the proposed standardized protocols and data acceptance criteria, comparable data from two additional laboratories were reviewed. The data acceptance criteria

  2. Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods

    PubMed Central

    Kelty, Catherine A.; Oshiro, Robin; Haugland, Richard A.; Madi, Tania; Brooks, Lauren; Field, Katharine G.; Sivaganesan, Mano

    2016-01-01

    There is growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data quality across laboratories. Data quality is typically determined through a series of specifications that ensure good experimental practice and the absence of bias in the results due to DNA isolation and amplification interferences. However, there is currently a lack of consensus on how best to evaluate and interpret human fecal source identification qPCR experiments. This is, in part, due to the lack of standardized protocols and information on interlaboratory variability under conditions for data acceptance. The aim of this study is to provide users and reviewers with a complete series of conditions for data acceptance derived from a multiple laboratory data set using standardized procedures. To establish these benchmarks, data from HF183/BacR287 and HumM2 human-associated qPCR methods were generated across 14 laboratories. Each laboratory followed a standardized protocol utilizing the same lot of reference DNA materials, DNA isolation kits, amplification reagents, and test samples to generate comparable data. After removal of outliers, a nested analysis of variance (ANOVA) was used to establish proficiency metrics that include lab-to-lab, replicate testing within a lab, and random error for amplification inhibition and sample processing controls. Other data acceptance measurements included extraneous DNA contamination assessments (no-template and extraction blank controls) and calibration model performance (correlation coefficient, amplification efficiency, and lower limit of quantification). To demonstrate the implementation of the proposed standardized protocols and data acceptance criteria, comparable data from two additional laboratories were reviewed. The data acceptance criteria

  3. Data Acceptance Criteria for Standardized Human-Associated Fecal Source Identification Quantitative Real-Time PCR Methods

    EPA Science Inventory

    There is a growing interest in the application of human-associated fecal sourceidentification quantitative real-time PCR (qPCR) technologies for water quality management. The transition from a research tool to a standardized protocol requires a high degree of confidence in data q...

  4. 7 CFR 1717.605 - Design standards, plans and specifications, construction standards, and RUS accepted materials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., construction standards, and RUS accepted materials. 1717.605 Section 1717.605 Agriculture Regulations of the... standards, plans and specifications, construction standards, and RUS accepted materials. All borrowers... system design, construction standards, and the use of RUS accepted materials. Borrowers must comply...

  5. Demystifying Learning Technology Standards. Part II: Acceptance and Implementation.

    ERIC Educational Resources Information Center

    Sonwalkar, Nishikant

    2002-01-01

    Discussion of learning technology standards focuses on acceptance and implementation, illustrated by SCORM specifications as applied to courseware development. Highlights include course structure; content hierarchy; multimedia assets; sharable content objects (SCOs); content aggregation; content packaging; categories of metadata; and content…

  6. Standard-E hydrogen monitoring system shop acceptance test procedure

    SciTech Connect

    Schneider, T.C.

    1997-10-02

    The purpose of this report is to document that the Standard-E Hydrogen Monitoring Systems (SHMS-E), fabricated by Mid-Columbia Engineering (MCE) for installation on the Waste Tank Farms in the Hanford 200 Areas, are constructed as intended by the design. The ATP performance will verify proper system fabrication.

  7. THE SEXUAL DOUBLE STANDARD AND ADOLESCENT PEER ACCEPTANCE*

    PubMed Central

    Kreager, Derek A.; Staff, Jeremy

    2014-01-01

    The belief that women and men are held to different standards of sexual conduct is pervasive in contemporary American society. According to the sexual double standard, boys and men are rewarded and praised for heterosexual sexual contacts, whereas girls and women are derogated and stigmatized for similar behaviors. Although widely held by the general public, research findings on the sexual double standard remain equivocal, with qualitative studies and early attitudinal surveys generally finding evidence of the double standard and more recent experimental vignette designs often failing to find similar results. In this study, we extend prior research by directly measuring the social status of sexually permissive youth. We use data collected from the National Longitudinal Study of Adolescent Health to relate adolescents’ self-reported numbers of sexual partners to a network measure of peer acceptance. Results suggest that the association between lifetime sexual partnerships and peer status varies significantly by gender, such that greater numbers of sexual partners are positively correlated with boys’ peer acceptance, but negatively correlated with girls’ peer acceptance. Moreover, the relationship between boys’ sexual behaviors and peer acceptance is moderated by socioeconomic origins; sexually permissive boys from disadvantaged backgrounds are predicted to have more friendships than permissive boys from more advantaged backgrounds. Our results thus support the existence of an adolescent sexual double standard and suggest that sexual norms vary by both gender and socioeconomic origins. PMID:25484478

  8. [Should IQWiG revise its methods of cost-effectiveness analysis in order to comply with more widely accepted health economical evaluation standards?].

    PubMed

    Lübbe, W

    2010-03-01

    IQWiG, Germany's equivalent to Britain's National Institute for Health and Clinical Excellence (NICE), has adopted an unorthodox method of cost-effectiveness analysis. The method does not use QALYs (quality adjusted life years). Its main point is that it tries to avoid comparative judgement on the relative value of treatment effects in different medical areas. The present contribution assesses the controversy that has arisen over IQWiG's methods by discussing a) whether comparative judgements will at least implicitly be made anyway as soon as the IQWiG makes reimbursement recommendations in more than one medical area, and b) whether the well-known fairness objections against QALY maximization can plausibly be dealt with by equity weigthing or, generally, by moving on to "societal value" maximization, which tries to include fairness values in addition to cost-effectiveness. It is concluded that the answer is "No" for both points, which leads to a "No" for the title question as well.

  9. Standardization of DOE Disposal Facilities Waste Acceptance Processes

    SciTech Connect

    Shrader, T. A.; Macbeth, P. J.

    2002-02-26

    On February 25, 2000, the U.S. Department of Energy (DOE) issued the Record of Decision (ROD) for the Waste Management Programmatic Environmental Impact Statement (WM PEIS) for low-level and mixed low-level wastes (LLW/ MLLW) treatment and disposal. The ROD designated the disposal sites at Hanford and the Nevada Test Site (NTS) to dispose of LLW/MLLW from sites without their own disposal facilities. DOE's Richland Operations Office (RL) and the National Nuclear Security Administration's Nevada Operations Office (NV) have been charged with effectively implementing the ROD. To accomplish this task NV and RL, assisted by their operating contractors Bechtel Nevada (BN), Fluor Hanford (FH), and Bechtel Hanford (BH) assembled a task team to systematically map out and evaluate the current waste acceptance processes and develop an integrated, standardized process for the acceptance of LLW/MLLW. A structured, systematic, analytical process using the Six Sigma system identified dispos al process improvements and quantified the associated efficiency gains to guide changes to be implemented. The review concluded that a unified and integrated Hanford/NTS Waste Acceptance Process would be a benefit to the DOE Complex, particularly the waste generators. The Six Sigma review developed quantitative metrics to address waste acceptance process efficiency improvements, and provides an initial look at development of comparable waste disposal cost models between the two disposal sites to allow quantification of the proposed improvements.

  10. Standardization of DOE Disposal Facilities Waste Acceptance Process

    SciTech Connect

    SHRADER, T.; MACBETH, P.

    2002-01-01

    On February 25, 2000, the US. Department of Energy (DOE) issued the Record of Decision (ROD) for the Waste Management Programmatic Environmental Impact Statement (WM PEIS) for low-level and mixed low-level wastes (LLW/ MLLW) treatment and disposal. The ROD designated the disposal sites at Hanford and the Nevada Test Site (NTS) to dispose of LLWMLLW from sites without their own disposal facilities. DOE's Richland Operations Office (RL) and the National Nuclear Security Administration's Nevada Operations Office (NV) have been charged with effectively implementing the ROD. To accomplish this task NV and RL, assisted by their operating contractors Bechtel Nevada (BN), Fluor Hanford (FH), and Bechtel Hanford (BH) assembled a task team to systematically map out and evaluate the current waste acceptance processes and develop an integrated, standardized process for the acceptance of LLWMLLW. A structured, systematic, analytical process using the Six Sigma system identified disposal process improvements and quantified the associated efficiency gains to guide changes to be implemented. The review concluded that a unified and integrated Hanford/NTS Waste Acceptance Process would be a benefit to the DOE Complex, particularly the waste generators. The Six Sigma review developed quantitative metrics to address waste acceptance process efficiency improvements, and provides an initial look at development of comparable waste disposal cost models between the two disposal sites to allow quantification of the proposed improvements.

  11. Testing biodegradability with standardized methods.

    PubMed

    Pagga, U

    1997-12-01

    Laboratory test methods are used by industry laboratories to determine biodegradability, an important parameter for the evaluation of the ecological behaviour of substances. Biodegradability has a key role due to the simple fact that a degradable substance will cause no long term risk in the environment. The great variety of biodegradation processes in the natural environment and in technical plants for treating waste water and solid wastes gave rise to a rather large number of test methods based on different test principles. To guarantee the acceptance of the test results by authorities and customers internationally standardized methods (ISO, OECD) and established quality criteria (GLP, EN 45,000, ISO 9000) are used. PMID:9415981

  12. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  13. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  14. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  15. 46 CFR 159.010-3 - Independent laboratory: Standards for acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Independent laboratory: Standards for acceptance. 159... Laboratory: Acceptance, Recognition, and Termination § 159.010-3 Independent laboratory: Standards for acceptance. (a) To be accepted by the Coast Guard as an independent laboratory, a laboratory must— (1)...

  16. 30 CFR 6.20 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... safety standards. 6.20 Section 6.20 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT... LABORATORIES AND NON-MSHA PRODUCT SAFETY STANDARDS § 6.20 MSHA acceptance of equivalent non-MSHA product safety standards. (a) MSHA will accept non-MSHA product safety standards, or groups of standards, as...

  17. 30 CFR 6.20 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... safety standards. 6.20 Section 6.20 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT... LABORATORIES AND NON-MSHA PRODUCT SAFETY STANDARDS § 6.20 MSHA acceptance of equivalent non-MSHA product safety standards. (a) MSHA will accept non-MSHA product safety standards, or groups of standards, as...

  18. 30 CFR 6.20 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... safety standards. 6.20 Section 6.20 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT... LABORATORIES AND NON-MSHA PRODUCT SAFETY STANDARDS § 6.20 MSHA acceptance of equivalent non-MSHA product safety standards. (a) MSHA will accept non-MSHA product safety standards, or groups of standards, as...

  19. 30 CFR 6.20 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LABORATORIES AND NON-MSHA PRODUCT SAFETY STANDARDS § 6.20 MSHA acceptance of equivalent non-MSHA product safety standards. (a) MSHA will accept non-MSHA product safety standards, or groups of standards, as equivalent... intent to review any non-MSHA product safety standard for equivalency in the Federal Register for...

  20. Standard environmental test methods

    SciTech Connect

    Schafer, D R

    1983-12-01

    This guide to uniformity in testing is intended primarily as an aid to persons responsible for designing, developing, and performing environmental tests. It will also be of use to those concerned with production, evaluation, and quality control and assurance. Checklists for preparing the environmental testing portion of product specifications are included, as are copies of Process Standards covering the instrumentation, equipment, and methods for use in environmental testing of Sandia National Laboratories components. Techniques and equipment are constantly improving. This version of SC-4452 reflects current state-of-the-art and practice in environmental testing. Previously existing sections of the document have ben updated and new ones have been added, e.g., Transient Testing on Vibration Machines.

  1. 15 CFR 10.6 - Procedures for acceptance of a recommended standard.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... recommended standard. 10.6 Section 10.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR THE DEVELOPMENT OF VOLUNTARY PRODUCT STANDARDS § 10.6 Procedures for acceptance of a recommended standard. (a) Upon receipt from the Standard Review Committee of a recommended standard and...

  2. The Sexual Double Standard and Adolescent Peer Acceptance

    ERIC Educational Resources Information Center

    Kreager, Derek A.; Staff, Jeremy

    2009-01-01

    The belief that women and men are held to different standards of sexual conduct is pervasive in contemporary American society. According to the sexual double standard, boys and men are rewarded and praised for heterosexual sexual contacts, whereas girls and women are derogated and stigmatized for similar behaviors. Although widely held by the…

  3. The Mapmark Standard Setting Method

    ERIC Educational Resources Information Center

    Schulz, E. Matthew; Mitzel, Howard C.

    2005-01-01

    A new standard setting method, Mapmark, was recently developed by ACT Inc. in the course of a contract with the National Assessment Governing Board (NAGB) to set achievement levels for the 2005 National Assessment of Educational Progress (NAEP) in Grade 12 mathematics. Mapmark includes elements of the bookmark method (Lewis, Mitzel, & Green, 1996;…

  4. 30 CFR 870.16 - Acceptable payment methods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.16 Acceptable payment methods. (a) If you owe total quarterly reclamation fees of $25,000 or...

  5. 30 CFR 870.16 - Acceptable payment methods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.16 Acceptable payment methods. (a) If you owe total quarterly reclamation fees of $25,000 or...

  6. 30 CFR 870.16 - Acceptable payment methods.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.16 Acceptable payment methods. (a) If you owe total quarterly reclamation fees of $25,000 or...

  7. 30 CFR 870.16 - Acceptable payment methods.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION ABANDONED MINE RECLAMATION FUND-FEE COLLECTION AND COAL PRODUCTION REPORTING § 870.16 Acceptable payment methods. (a) If you owe total quarterly reclamation fees of $25,000 or...

  8. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance...

  9. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance...

  10. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance...

  11. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance...

  12. 49 CFR 195.228 - Welds and welding inspection: Standards of acceptability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welds and welding inspection: Standards of... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.228 Welds and welding inspection: Standards of acceptability. (a) Each weld and welding must be inspected to insure compliance...

  13. Melanins and melanogenesis: methods, standards, protocols.

    PubMed

    d'Ischia, Marco; Wakamatsu, Kazumasa; Napolitano, Alessandra; Briganti, Stefania; Garcia-Borron, José-Carlos; Kovacs, Daniela; Meredith, Paul; Pezzella, Alessandro; Picardo, Mauro; Sarna, Tadeusz; Simon, John D; Ito, Shosuke

    2013-09-01

    Despite considerable advances in the past decade, melanin research still suffers from the lack of universally accepted and shared nomenclature, methodologies, and structural models. This paper stems from the joint efforts of chemists, biochemists, physicists, biologists, and physicians with recognized and consolidated expertise in the field of melanins and melanogenesis, who critically reviewed and experimentally revisited methods, standards, and protocols to provide for the first time a consensus set of recommended procedures to be adopted and shared by researchers involved in pigment cell research. The aim of the paper was to define an unprecedented frame of reference built on cutting-edge knowledge and state-of-the-art methodology, to enable reliable comparison of results among laboratories and new progress in the field based on standardized methods and shared information.

  14. Virtual glaucoma clinics: patient acceptance and quality of patient education compared to standard clinics

    PubMed Central

    Court, Jennifer H; Austin, Michael W

    2015-01-01

    Purpose Virtual glaucoma clinics allow rapid, reliable patient assessment but the service should be acceptable to patients and concordance with treatment needs to be maintained with adequate patient education. This study compares experiences and understanding of patients reviewed via the virtual clinic versus the standard clinic by way of an extended patient satisfaction questionnaire (PSQ). Patients and methods One hundred PSQs were given to consecutive patients attending glaucoma clinics in October 2013. All 135 patients reviewed via the virtual clinic from April 2013 until August 2013 were sent postal PSQs in September 2013. Data were obtained for demographics, understanding of glaucoma, their condition, satisfaction with their experience, and quality of information. Responses were analyzed in conjunction with the clinical records. Results Eighty-five percent of clinic patients and 63% of virtual clinic patients responded to the PSQ. The mean satisfaction score was over 4.3/5 in all areas surveyed. Virtual clinic patients’ understanding of their condition was very good, with 95% correctly identifying their diagnosis as glaucoma, 83% as ocular hypertension and 78% as suspects. There was no evidence to support inferior knowledge or self-perceived understanding compared to standard clinic patients. Follow-up patients knew more about glaucoma than new patients. Over 95% of patients found our information leaflet useful. Forty percent of patients sought additional information but less than 20% used the internet for this. Conclusion A substantial proportion of glaucoma pathway patients may be seen by non-medical staff supervised by glaucoma specialists via virtual clinics. Patients are accepting of this format, reporting high levels of satisfaction and non-inferior knowledge to those seen in standard clinics. PMID:25987832

  15. Standardized Methods for Electronic Shearography

    NASA Technical Reports Server (NTRS)

    Lansing, Matthew D.

    1997-01-01

    Research was conducted in development of operating procedures and standard methods to evaluate fiber reinforced composite materials, bonded or sprayed insulation, coatings, and laminated structures with MSFC electronic shearography systems. Optimal operating procedures were developed for the Pratt and Whitney Electronic Holography/Shearography Inspection System (EH/SIS) operating in shearography mode, as well as the Laser Technology, Inc. (LTI) SC-4000 and Ettemeyer SHS-94 ISTRA shearography systems. Operating practices for exciting the components being inspected were studied, including optimal methods for transient heating with heat lamps and other methods as appropriate to enhance inspection capability.

  16. Acceptance Factors Influencing Adoption of National Institute of Standards and Technology Information Security Standards: A Quantitative Study

    ERIC Educational Resources Information Center

    Kiriakou, Charles M.

    2012-01-01

    Adoption of a comprehensive information security governance model and security controls is the best option organizations may have to protect their information assets and comply with regulatory requirements. Understanding acceptance factors of the National Institute of Standards and Technology (NIST) Risk Management Framework (RMF) comprehensive…

  17. 30 CFR 6.20 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false MSHA acceptance of equivalent non-MSHA product safety standards. 6.20 Section 6.20 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS TESTING AND EVALUATION BY INDEPENDENT LABORATORIES AND NON-MSHA PRODUCT...

  18. 46 CFR 10.409 - Coast Guard-accepted Quality Standard System (QSS) organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Coast Guard-accepted Quality Standard System (QSS) organizations. 10.409 Section 10.409 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MERCHANT MARINER CREDENTIAL Training Courses and Programs § 10.409 Coast...

  19. 46 CFR 8.250 - Acceptance of standards and functions delegated under existing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Recognition of a Classification Society § 8.250 Acceptance of standards and functions delegated under existing regulations. (a) Classification society class... society has received authorization to conduct a related delegated function. (b) A...

  20. 46 CFR 8.250 - Acceptance of standards and functions delegated under existing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Recognition of a Classification Society § 8.250 Acceptance of standards and functions delegated under existing regulations. (a) Classification society class... society has received authorization to conduct a related delegated function. (b) A...

  1. 46 CFR 8.250 - Acceptance of standards and functions delegated under existing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Recognition of a Classification Society § 8.250 Acceptance of standards and functions delegated under existing regulations. (a) Classification society class... society has received authorization to conduct a related delegated function. (b) A...

  2. 46 CFR 8.250 - Acceptance of standards and functions delegated under existing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Recognition of a Classification Society § 8.250 Acceptance of standards and functions delegated under existing regulations. (a) Classification society class... society has received authorization to conduct a related delegated function. (b) A...

  3. 46 CFR 8.250 - Acceptance of standards and functions delegated under existing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Recognition of a Classification Society § 8.250 Acceptance of standards and functions delegated under existing regulations. (a) Classification society class... society has received authorization to conduct a related delegated function. (b) A...

  4. [Writing English abstracts of high quality in standard English acceptable for publication].

    PubMed

    Zheng, Jia-wei; Zhang, Zhi-yuan

    2004-04-01

    Writing an abstract presents a unique challenge to any author. It requires brevity of the written word, conciseness of thought and accuracy of presentation. A structured abstract is the most important starting point for a well written dental article. Shanghai Journal of Stomatology, a Chinese national journal of oral medicine, oral and maxillofacial surgery, prosthodontics, orthodontics, oral pathology, endodontics, oral radiology, etc, has been included and indexed in Chemical Abstracts, Index Medicus and MEDLINE. This peer reviewed refereed journal demands Chinese and English abstracts of high quality for all manuscripts. Each manuscript should provide qualified abstracts for citation and indexing, which are written in standard English using the correct terms, sentences and grammar. Structured abstracts about 500 characters are required for clinical articles, clinical reports, basic scientific articles; while indicative abstracts (summary) are mandatory to short communications and case reports as well as review articles. Generally, the abstracts should be written in the past tense and passive voice (in the third person), with exception of conclusion(s), which can be in the primary tense and active voice. The structured abstracts are consisted of PURPOSE (S), METHODS, CONCLUSION (S), and CONCLUSION (S), which should offer the important information on the number of the subjects, methods of grouping and statistics, database attained, P values, etc. The conclusion (s) must be detailed rather than conceptive. This editorial introduces the ins and outs of writing an English abstracts acceptable for publication.

  5. [Writing English abstracts of high quality in standard English acceptable for publication].

    PubMed

    Zheng, Jia-wei; Zhang, Zhi-yuan

    2004-04-01

    Writing an abstract presents a unique challenge to any author. It requires brevity of the written word, conciseness of thought and accuracy of presentation. A structured abstract is the most important starting point for a well written dental article. Shanghai Journal of Stomatology, a Chinese national journal of oral medicine, oral and maxillofacial surgery, prosthodontics, orthodontics, oral pathology, endodontics, oral radiology, etc, has been included and indexed in Chemical Abstracts, Index Medicus and MEDLINE. This peer reviewed refereed journal demands Chinese and English abstracts of high quality for all manuscripts. Each manuscript should provide qualified abstracts for citation and indexing, which are written in standard English using the correct terms, sentences and grammar. Structured abstracts about 500 characters are required for clinical articles, clinical reports, basic scientific articles; while indicative abstracts (summary) are mandatory to short communications and case reports as well as review articles. Generally, the abstracts should be written in the past tense and passive voice (in the third person), with exception of conclusion(s), which can be in the primary tense and active voice. The structured abstracts are consisted of PURPOSE (S), METHODS, CONCLUSION (S), and CONCLUSION (S), which should offer the important information on the number of the subjects, methods of grouping and statistics, database attained, P values, etc. The conclusion (s) must be detailed rather than conceptive. This editorial introduces the ins and outs of writing an English abstracts acceptable for publication. PMID:15133543

  6. Standard-B auto grab sampler hydrogen monitoring system, Acceptance Test Report

    SciTech Connect

    Lott, D.T.

    1995-05-18

    Project W-369, Watch List Tank Hydrogen Monitors, installed a Standard-C Hydrogen Monitoring System (SHMS) on the Flammable gas waste tank AN-104. General Support Projects (8K510) was support by Test Engineering (7CH30) in the performance of the Acceptance Test Procedures (ATP) to qualify the SHMS cabinets on the waste tank. The ATP`s performance was controlled by Tank Farm work package. This completed ATP is transmitted by EDT-601748 as an Acceptance Test Report (ATR) in accordance with WHC-6-1, EP 4.2 and EP 1.12.

  7. Formulation of a candidate glass for use as an acceptance test standard material

    SciTech Connect

    Ebert, W.L.; Strachan, D.M.; Wolf, S.F.

    1998-04-01

    In this report, the authors discuss the formulation of a glass that will be used in a laboratory testing program designed to measure the precision of test methods identified in the privatization contracts for the immobilization of Hanford low-activity wastes. Tests will be conducted with that glass to measure the reproducibility of tests and analyses that must be performed by glass producers as a part of the product acceptance procedure. Test results will be used to determine if the contractually required tests and analyses are adequate for evaluating the acceptability of likely immobilized low-activity waste (ILAW) products. They will also be used to evaluate if the glass designed for use in these tests can be used as an analytical standard test material for verifying results reported by vendors for tests withg ILAW products. The results of those tests and analyses will be presented in a separate report. The purpose of this report is to document the strategy used to formulate the glass to be used in the testing program. The low-activity waste reference glass LRM that will be used in the testing program was formulated to be compositionally similar to ILAW products to be made with wastes from Hanford. Since the ILAW product compositions have not been disclosed by the vendors participating in the Hanford privatization project, the composition of LRM was formulated based on simulated Hanford waste stream and amounts of added glass forming chemicals typical for vitrified waste forms. The major components are 54 mass % SiO{sub 2}, 20 mass % Na{sub 2}O, 10 mass % Al{sub 2}O{sub 3}, 8 mass % B{sub 2}O{sub 3}, and 1.5 mass % K{sub 2}O. Small amounts of other chemicals not present in Hanford wastes were also included in the glass, since they may be included as chemical additives in ILAW products. This was done so that the use of LRM as a composition standard could be evaluated. Radionuclides were not included in LRM because a nonradioactive material was desired.

  8. Radioactive waste management: review on clearance levels and acceptance criteria legislation, requirements and standards.

    PubMed

    Maringer, F J; Suráň, J; Kovář, P; Chauvenet, B; Peyres, V; García-Toraño, E; Cozzella, M L; De Felice, P; Vodenik, B; Hult, M; Rosengård, U; Merimaa, M; Szücs, L; Jeffery, C; Dean, J C J; Tymiński, Z; Arnold, D; Hinca, R; Mirescu, G

    2013-11-01

    In 2011 the joint research project Metrology for Radioactive Waste Management (MetroRWM)(1) of the European Metrology Research Programme (EMRP) started with a total duration of three years. Within this project, new metrological resources for the assessment of radioactive waste, including their calibration with new reference materials traceable to national standards will be developed. This paper gives a review on national, European and international strategies as basis for science-based metrological requirements in clearance and acceptance of radioactive waste.

  9. A data base and a standard material for use in acceptance testing of low-activity waste products

    SciTech Connect

    Wolf, S.F.; Ebert, W.L.; Luo, J.S.; Strachan, D.M.

    1998-04-01

    The authors have conducted replicate dissolution tests following the product consistency test (PCT) procedure to measure the mean and standard deviation of the solution concentrations of B, Na, and Si at various combinations of temperature, duration, and glass/water mass ratio. Tests were conducted with a glass formulated to be compositionally similar to low-activity waste products anticipated for Hanford to evaluate the adequacy of test methods that have been designated in privatization contracts for use in product acceptance. An important finding from this set of tests is that the solution concentrations generated in tests at 20 C will likely be too low to measure the dissolution rates of waste products reliably. Based on these results, the authors recommend that the acceptance test be conducted at 40 C. Tests at 40 C generated higher solution concentrations, were more easily conducted, and the measured rates were easily related to those at 20 C. Replicate measurements of other glass properties were made to evaluate the possible use of LRM-1 as a standard material. These include its composition, homogeneity, density, compressive strength, the Na leachability index with the ANSI/ANS 16.1 leach test, and if the glass is characteristically hazardous with the toxicity characteristic leach procedure. The values of these properties were within the acceptable limits identified for Hanford low-activity waste products. The reproducibility of replicate tests and analyses indicates that the glass would be a suitable standard material.

  10. 77 FR 10358 - Acceptance of ASTM F963-11 as a Mandatory Consumer Product Safety Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Chapter II Acceptance of ASTM F963-11 as a Mandatory Consumer Product Safety Standard AGENCY: Consumer Product Safety Commission. ACTION: Acceptance of standard. SUMMARY: The Consumer...

  11. Correction methods for finite-acceptance effects in two-particle correlation analyses

    NASA Astrophysics Data System (ADS)

    Oh, Saehanseul; Morsch, Andreas; Loizides, Constantin; Schuster, Tim

    2016-08-01

    Two-particle angular correlations have been widely used as a tool to explore particle production mechanisms in heavy-ion collisions. The mixed-event technique is generally used as a standard method to correct for finite-acceptance effects. We demonstrate that event mixing only provides an approximate acceptance correction, and propose new methods for finite-acceptance corrections. Starting from discussions about 2-dimensional correction procedures, new methods are derived for specific assumptions on the properties of the signal, such as uniform signal distribution or δ-function-like trigger particle distribution, and suitable for two-particle correlation analyses from particles at mid-rapidity and jet-hadron or high p T -triggered hadron-hadron correlations. Per-trigger associated particle yields from the mixed-event method and the new methods are compared through Monte Carlo simulations containing well-defined correlation signals. Significant differences are observed at large pseudorapidity differences in general and especially for asymmetric particle distribution like that produced in proton-nucleus collisions. The applicability and validity of the new methods are discussed in detail.

  12. Dental Hygiene Faculty Calibration Using Two Accepted Standards for Calculus Detection: A Pilot Study.

    PubMed

    Santiago, Lisa J; Freudenthal, Jacqueline J; Peterson, Teri; Bowen, Denise M

    2016-08-01

    Faculty calibration studies for calculus detection use two different standards for examiner evaluation, yet the only therapeutic modality that can be used for nonsurgical periodontal treatment is scaling/root debridement or planing. In this study, a pretest-posttest design was used to assess the feasibility of faculty calibration for calculus detection using two accepted standards: that established by the Central Regional Dental Testing Service, Inc. (CRDTS; readily detectible calculus) and the gold standard for scaling/root debridement (root roughness). Four clinical dental hygiene faculty members out of five possible participants at Halifax Community College agreed to participate. The participants explored calculus on the 16 assigned teeth (64 surfaces) of four patients. Calculus detection scores were calculated before and after training. Kappa averages using CRDTS criteria were 0.561 at pretest and 0.631 at posttest. Kappa scores using the scaling/root debridement or planing standard were 0.152 at pretest and 0.271 at posttest. The scores indicated improvement from moderate (Kappa=0.41-0.60) to substantial agreement (Kappa=0.61-0.80) following training using the CRDTS standard. Although this result differed qualitatively and Kappas were significantly different from 0, the differences for pre- to post-Kappas for patient-rater dyads using CRDTS were not statistically significant (p=0.778). There was no difference (p=0.913) in Kappa scores pre- to post-training using the scaling/root debridement standard. Despite the small number of participants in this study, the results indicated that training to improve interrater reliability to substantial agreement was feasible using the CRDTS standard but not using the gold standard. The difference may have been due to greater difficulty in attaining agreement regarding root roughness. Future studies should include multiple training sessions with patients using the same standard for scaling/root debridement used for

  13. Incentives for Organ Donation: Proposed Standards for an Internationally Acceptable System

    PubMed Central

    2012-01-01

    Incentives for organ donation, currently prohibited in most countries, may increase donation and save lives. Discussion of incentives has focused on two areas: (1) whether or not there are ethical principles that justify the current prohibition and (2) whether incentives would do more good than harm. We herein address the second concern and propose for discussion standards and guidelines for an acceptable system of incentives for donation. We believe that if systems based on these guidelines were developed, harms would be no greater than those to today’s conventional donors. Ultimately, until there are trials of incentives, the question of benefits and harms cannot be satisfactorily answered. PMID:22176925

  14. Survey of methods for improving operator acceptance of computerized aids

    SciTech Connect

    Frey, P. R.; Kisner, R. A.

    1982-04-01

    The success of current attempts to improve the operational performance and safety of nuclear power plants by installing computerized operational aids in the control rooms is dependent, in part, on the operator's attitude toward the aid. Utility experience with process computer systems indicates that problems may already exist with operator acceptance of computerized aids. The growth of the role that computers have in nuclear power plants makes user acceptance of computer technology an important issue for the nuclear industry. The purpose of this report is to draw from the literature factors related to user acceptance of computerized equipment that may also be applicable to the acceptance of computerized aids used in the nuclear power plant control room.

  15. Towards internationally acceptable standards for food additives and contaminants based on the use of risk analysis.

    PubMed

    Huggett, A; Petersen, B J; Walker, R; Fisher, C E; Notermans, S H; Rombouts, F M; Abbott, P; Debackere, M; Hathaway, S C; Hecker, E F; Knaap, A G; Kuznesof, P M; Meyland, I; Moy, G; Narbonne, J F; Paakkanen, J; Smith, M R; Tennant, D; Wagstaffe, P; Wargo, J; Würtzen, G

    1998-06-01

    Internationally acceptable norms need to incorporate sound science and consistent risk management principles in an open and transparent manner, as set out in the Agreement on the Application of Sanitary and Phytosanitary Measures (the SPS Agreement). The process of risk analysis provides a procedure to reach these goals. The interaction between risk assessors and risk managers is considered vital to this procedure. This paper reports the outcome of a meeting of risk assessors and risk managers on specific aspects of risk analysis and its application to international standard setting for food additives and contaminants. Case studies on aflatoxins and aspartame were used to identify the key steps of the interaction process which ensure scientific justification for risk management decisions. A series of recommendations were proposed in order to enhance the scientific transparency in these critical phases of the standard setting procedure.

  16. 19 CFR 24.13a - Car, compartment, and package seals; and fastenings; standards; acceptance by Customs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Car, compartment, and package seals; and... PROCEDURE § 24.13a Car, compartment, and package seals; and fastenings; standards; acceptance by Customs. (a) General standards. The seals and fastenings, together, shall (1) Be strong and durable; (2) Be capable...

  17. 19 CFR 24.13a - Car, compartment, and package seals; and fastenings; standards; acceptance by Customs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Car, compartment, and package seals; and... PROCEDURE § 24.13a Car, compartment, and package seals; and fastenings; standards; acceptance by Customs. (a) General standards. The seals and fastenings, together, shall (1) Be strong and durable; (2) Be capable...

  18. 19 CFR 24.13a - Car, compartment, and package seals; and fastenings; standards; acceptance by Customs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Car, compartment, and package seals; and... PROCEDURE § 24.13a Car, compartment, and package seals; and fastenings; standards; acceptance by Customs. (a) General standards. The seals and fastenings, together, shall (1) Be strong and durable; (2) Be capable...

  19. 19 CFR 24.13a - Car, compartment, and package seals; and fastenings; standards; acceptance by Customs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Car, compartment, and package seals; and... PROCEDURE § 24.13a Car, compartment, and package seals; and fastenings; standards; acceptance by Customs. (a) General standards. The seals and fastenings, together, shall (1) Be strong and durable; (2) Be capable...

  20. Qualitative methods to ensure acceptability of behavioral and social interventions to the target population

    PubMed Central

    Ayala, Guadalupe X.; Elder, John P.

    2013-01-01

    This paper introduces qualitative methods for assessing the acceptability of an intervention. Acceptability refers to determining how well an intervention will be received by the target population and the extent to which the new intervention or its components might meet the needs of the target population and organizational setting. In this paper, we focus on two common qualitative methods for conducting acceptability research and their advantages and disadvantages: focus groups and interviews. We provide examples from our own research and other studies to demonstrate the use of these methods for conducting acceptability research and how one might adapt this approach for oral health research. Finally, we present emerging methods for conducting acceptability research, including the use of community-based participatory research, as well as the utility of conducting acceptability research for assessing the appropriateness of measures in intervention research. PMID:21656958

  1. Probabilistic Requirements (Partial) Verification Methods Best Practices Improvement. Variables Acceptance Sampling Calculators: Empirical Testing. Volume 2

    NASA Technical Reports Server (NTRS)

    Johnson, Kenneth L.; White, K. Preston, Jr.

    2012-01-01

    The NASA Engineering and Safety Center was requested to improve on the Best Practices document produced for the NESC assessment, Verification of Probabilistic Requirements for the Constellation Program, by giving a recommended procedure for using acceptance sampling by variables techniques as an alternative to the potentially resource-intensive acceptance sampling by attributes method given in the document. In this paper, the results of empirical tests intended to assess the accuracy of acceptance sampling plan calculators implemented for six variable distributions are presented.

  2. Social Acceptability of Menstrual-Care Training Methods for Young Women with Developmental Disabilities.

    ERIC Educational Resources Information Center

    Epps, Susan; And Others

    1990-01-01

    The acceptability of two different training methods (simulation training using a doll and simulation training on self) for teaching menstrual hygiene skills to young women with developmental disabilities was evaluated in two experiments. Results suggested that opinions about treatment acceptability should be obtained from both professional and…

  3. 19 CFR 24.13a - Car, compartment, and package seals; and fastenings; standards; acceptance by Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Car, compartment, and package seals; and fastenings; standards; acceptance by Customs. 24.13a Section 24.13a Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.13a Car, compartment,...

  4. Study Methods to Standardize Thermography NDE

    NASA Technical Reports Server (NTRS)

    Walker, James L.; Workman, Gary L.

    1998-01-01

    The purpose of this work is to develop thermographic inspection methods and standards for use in evaluating structural composites and aerospace hardware. Qualification techniques and calibration methods are investigated to standardize the thermographic method for use in the field. Along with the inspections of test standards structural hardware, support hardware is designed and fabricated to aid in the thermographic process. Also, a standard operating procedure is developed for performing inspections with the Bales Thermal Image Processor (TIP). Inspections are performed on a broad range of structural composites. These materials include graphite/epoxies, graphite/cyanide-ester, graphite/silicon-carbide, graphite phenolic and Kevlar/epoxy. Also metal honeycomb (titanium and aluminum faceplates over an aluminum honeycomb core) structures are investigated. Various structural shapes are investigated and the thickness of the structures vary from as few as 3 plies to as many as 80 plies. Special emphasis is placed on characterizing defects in attachment holes and bondlines, in addition to those resulting from impact damage and the inclusion of foreign matter. Image processing through statistical analysis and digital filtering is investigated to enhance the quality and quantify the NDE thermal images when necessary.

  5. Study Methods to Standardize Thermography NDE

    NASA Technical Reports Server (NTRS)

    Walker, James L.; Workman, Gary L.

    1998-01-01

    The purpose of this work is to develop thermographic inspection methods and standards for use in evaluating structural composites and aerospace hardware. Qualification techniques and calibration methods are investigated to standardize the thermographic method for use in the field. Along with the inspections of test standards structural hardware, support hardware is designed and fabricated to aid in the thermographic process. Also, a standard operating procedure is developed for performing inspections with the Bales Thermal Image Processor (TIP). Inspections are performed on a broad range of structural composites. These materials include various graphite/epoxies, graphite/cyanide-ester, graphite/silicon-carbide, graphite phenolic and Keviar/epoxy. Also metal honeycomb (titanium and aluminum faceplates over an aluminum honeycomb core) structures are investigated. Various structural shapes are investigated and the thickness of the structures vary from as few as 3 plies to as many as 80 plies. Special emphasis is placed on characterizing defects in attachment holes and bondlines, in addition to those resulting from impact damage and the inclusion of foreign matter. Image processing through statistical analysis and digital filtering is investigated to enhance the quality and quantify the NDE thermal images when necessary.

  6. Standardization of 134Cs by three methods.

    PubMed

    García-Toraño, E; Rodríguez, Barquero L; Roteta, M

    2002-01-01

    The nuclide 34Cs decays by beta-emission followed by gamma-deexcitation to 134Ba with a half-life T(1/2) = 2.065 a. It has been standardized by three methods: liquid scintillation counting (LSC), 4pi beta-gamma coincidence counting and 4pi gamma counting. In the LSC measurements, the CIEMAT/NIST method was used to calculate the efficiency. For the coincidence measurements, a conventional 4pi beta (proportional counter)-gamma(NaI) system was used. For the 4pi gamma standardization, a well-type Nal(Tl) detector was modeled with the Monte Carlo package PENELOPE, and the counting efficiency obtained by calculation. Results of the three methods agree within 0.65%.

  7. Comparison of acceptance-based and standard cognitive-based coping strategies for craving sweets in overweight and obese women.

    PubMed

    Forman, Evan M; Hoffman, Kimberly L; Juarascio, Adrienne S; Butryn, Meghan L; Herbert, James D

    2013-01-01

    Existing strategies for coping with food cravings are of unknown efficacy and rely on principles that have been shown to have paradoxical effects. The present study evaluated novel, acceptance-based strategies for coping with craving by randomly assigning 48 overweight women to either an experimental psychological acceptance-oriented intervention or a standard cognitive reappraisal/distraction intervention. Participants were required to carry a box of sweets on their person for 72 h while abstaining from any consumption of sweets. Results suggested that the acceptance-based coping strategies resulted in lower cravings and reduced consumption, particularly for those who demonstrate greater susceptibility to the presence of food and report a tendency to engage in emotional eating.

  8. 7 CFR 1755.400 - RUS standard for acceptance tests and measurements of telecommunications plant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... measurements of telecommunications plant. Sections 1755.400 through 1755.407 cover the requirements for acceptance tests and measurements on installed copper and fiber optic telecommunications plant and equipment. ... telecommunications plant. 1755.400 Section 1755.400 Agriculture Regulations of the Department of...

  9. 7 CFR 1755.400 - RUS standard for acceptance tests and measurements of telecommunications plant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... measurements of telecommunications plant. Sections 1755.400 through 1755.407 cover the requirements for acceptance tests and measurements on installed copper and fiber optic telecommunications plant and equipment. ... telecommunications plant. 1755.400 Section 1755.400 Agriculture Regulations of the Department of...

  10. 7 CFR 1755.400 - RUS standard for acceptance tests and measurements of telecommunications plant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... measurements of telecommunications plant. Sections 1755.400 through 1755.407 cover the requirements for acceptance tests and measurements on installed copper and fiber optic telecommunications plant and equipment. ... telecommunications plant. 1755.400 Section 1755.400 Agriculture Regulations of the Department of...

  11. 7 CFR 1755.400 - RUS standard for acceptance tests and measurements of telecommunications plant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... measurements of telecommunications plant. Sections 1755.400 through 1755.407 cover the requirements for acceptance tests and measurements on installed copper and fiber optic telecommunications plant and equipment. ... telecommunications plant. 1755.400 Section 1755.400 Agriculture Regulations of the Department of...

  12. 7 CFR 1755.400 - RUS standard for acceptance tests and measurements of telecommunications plant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... measurements of telecommunications plant. Sections 1755.400 through 1755.407 cover the requirements for acceptance tests and measurements on installed copper and fiber optic telecommunications plant and equipment. ... telecommunications plant. 1755.400 Section 1755.400 Agriculture Regulations of the Department of...

  13. 75 FR 34953 - Existence of Proposed Airworthiness Design Standards for Acceptance Under the Primary Category...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ... Acceptance Under the Primary Category Rule; Orlando Helicopter Airways (OHA), Inc., Models Cessna 172I, 172K... regulations for primary category aircraft. DATES: Comments must be received on or before July 21, 2010... the hours of 7:30 a.m. and 4 p.m. weekdays, except Federal holidays. Background The...

  14. 30 CFR 7.10 - MSHA acceptance of equivalent non-MSHA product safety standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... applicable to this part 7. (1) MSHA will accept applications for motors under Subpart J designed and tested... Explosive Gas Atmospheres, Part 0, General Requirements (IEC 60079-0, Fourth Edition, 2004-01) and Part 1, Electrical Apparatus for Explosive Gas Atmospheres, Flameproof Enclosures “d” (IEC 60079-1, Fifth...

  15. [Knowledge, acceptability and use of the Billings natural family planning method].

    PubMed

    Uchimura, Nelson Shozo; Uchimura, Taqueco Teruya; Almeida, Lívia Maria Martins; Perego, Danilo Marco; Uchimura, Liza Yurie Teruya

    2011-09-01

    This is an observational quantitative and analytical study aimed at verifying the knowledge, acceptability and use of natural family planning (NFP) by patients in a university hospital from July to November, 2008. The data were collected using a structured questionnaire and analyzed with the softwares Excel and Statistica 8.0. Of the 113s women interviewed, 70 (62%) accepted the method and 1 (0.9%) used it routinely. Acceptance was higher among those who wished to become pregnant in the future compared to those who did not wish it. Acceptability was statistically significant (p = 0.0147) among the 28 (80%) non-contraceptive users compared to 42 (53.8%) who used some contraceptive method. Factors such as age, education, number of living children and religion were not statiscally associated with the acceptability of NFP. The Billings ovulation method has an adequate acceptability, but has a low actual use because of the lack of information by health professionals of its real effectiveness and applicability.

  16. Nuclear Structure: Going Beyond Standard Methods

    NASA Astrophysics Data System (ADS)

    Glick, Jennifer; Zelevinsky, Vladimir

    2013-04-01

    Many features of nuclear structure in medium and heavy nuclei are traditionally described by methods borrowed from macroscopic many-body physics, such as random phase approximation (RPA), or pairing theory according to BCS and HFB. These methods are routinely used when the exact large-scale diagonalization of the Hamiltonian matrix is impossible. The approximations inherently present in such methods, being appropriate in macroscopic physics, may introduce substantial errors for mesoscopic systems, such as atomic nuclei or cold atoms in traps. We develop the theory of collective motion based on exact particle number conservation. The first applications to the ground state physics (collaboration with A. Volya) demonstrated that such an approach avoids well known deficiencies of the standard treatment. Now we apply the method to low-lying collective excitations which are even more sensitive to conservation laws. The new RPA version is reduced to the set of recurrence relations for neighboring nuclei. We show that it is especially important for the cases of strong anharmonicity and in the vicinity of the instability point. Other examples are discussed where the advance beyond standard approaches gives new physical results.

  17. Using Financial Information in Continuing Education. Accepted Methods and New Approaches.

    ERIC Educational Resources Information Center

    Matkin, Gary W.

    This book, which is intended as a resource/reference guide for experienced financial managers and course planners, examines accepted methods and new approaches for using financial information in continuing education. The introduction reviews theory and practice, traditional and new methods, planning and organizational management, and technology.…

  18. Standardization of (55)Fe by tracing method.

    PubMed

    Koskinas, M F; Pires, C A; Yamazaki, I M; Silva, E A; Dias, M S

    2008-01-01

    This work describes the procedure followed by the Laboratório de Metrologia Nuclear (LMN) for the standardization of (55)Fe by the tracing method. This technique was applied using two radionuclides, which decay by the electron capture process followed by a prompt gamma-ray, namely (51)Cr and (54)Mn, as tracers. The calibration was performed in a 4pibeta-gamma coincidence system. The efficiency was obtained by selecting a gamma-ray window set at the 320keV total absorption peak for (51)Cr and at 834keV for (54)Mn. PMID:18342526

  19. The Objective Borderline Method: A Probabilistic Method for Standard Setting

    ERIC Educational Resources Information Center

    Shulruf, Boaz; Poole, Phillippa; Jones, Philip; Wilkinson, Tim

    2015-01-01

    A new probability-based standard setting technique, the Objective Borderline Method (OBM), was introduced recently. This was based on a mathematical model of how test scores relate to student ability. The present study refined the model and tested it using 2500 simulated data-sets. The OBM was feasible to use. On average, the OBM performed well…

  20. Standard Test Methods for Textile Composites

    NASA Technical Reports Server (NTRS)

    Masters, John E.; Portanova, Marc A.

    1996-01-01

    Standard testing methods for composite laminates reinforced with continuous networks of braided, woven, or stitched fibers have been evaluated. The microstructure of these textile' composite materials differs significantly from that of tape laminates. Consequently, specimen dimensions and loading methods developed for tape type composites may not be applicable to textile composites. To this end, a series of evaluations were made comparing testing practices currently used in the composite industry. Information was gathered from a variety of sources and analyzed to establish a series of recommended test methods for textile composites. The current practices established for laminated composite materials by ASTM and the MIL-HDBK-17 Committee were considered. This document provides recommended test methods for determining both in-plane and out-of-plane properties. Specifically, test methods are suggested for: unnotched tension and compression; open and filled hole tension; open hole compression; bolt bearing; and interlaminar tension. A detailed description of the material architectures evaluated is also provided, as is a recommended instrumentation practice.

  1. 24 CFR Appendix II to Subpart C of... - Development of Standards; Calculation Methods

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; Calculation Methods II Appendix II to Subpart C of Part 51 Housing and Urban Development Office of the...; Calculation Methods I. Background Information Concerning the Standards (a) Thermal Radiation: (1) Introduction... some distance away from the site of the fire. (2) Criteria for Acceptable Separation Distance...

  2. 75 FR 52860 - Final Airworthiness Design Standards for Acceptance Under the Primary Category Rule; Orlando...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Register on June 21, 2010, 75 FR 34953. No comments were received, and the airworthiness design standards... Under the Primary Category Rule; Orlando Helicopter Airways (OHA), Inc., Models Cessna 172I, 172K, 172L... under primary category regulations of modified Cessna 172I, 172K, 172L, and 172M airplanes. DATES:...

  3. The Acceptability and Representativeness of Standardized Parent-Child Interaction Tasks

    ERIC Educational Resources Information Center

    Rhule, Dana M.; McMahon, Robert J.; Vando, Jessica

    2009-01-01

    Analogue behavioral observation of structured parent-child interactions has often been used to obtain a standardized, unbiased measure of child noncompliance and parenting behavior. However, for assessment information to be clinically relevant, it is essential that the behavior observed be similar to that which the child normally experiences and…

  4. Standard test method for size of anthracite

    SciTech Connect

    Not Available

    1980-01-01

    This method covering screen analysis of anthracite is used to determine the percentage of undersize or oversize in ny given commercial size. The values stated in inch-pound units are to be regarded as the standard. Procedure, in case th coal is wet, air-dryit before screening. Determine the undersize first. For broken, egg, and stove sizes, up-end each piece by hand on the screen, to determine whether in any position it passes through the screen. For nut, pea, buckwheat, and rice sizes, shake the screens gently with a reciprocating horizontal motion, so as to avoid breakage ofthe coal, until practically no more coal will pass through the openings. Screen the coal in such increments as will allow the pieces to be in direct contact with the screen openings after the completion of the shaking of each increment.

  5. Standard method for characterizing SERS substrates

    NASA Astrophysics Data System (ADS)

    Guicheteau, Jason A.; Hankus, Mikella E.; Christesen, Steven D.; Fountain, Augustus W., III; Pellegrino, Paul M.; Emmons, Erik D.; Tripathi, Ashish; Wilcox, Phillip; Emge, Darren

    2012-06-01

    We present the methodology and results of a standard assessment protocol to evaluate disparate SERS substrates that were developed for the Defense Advanced Research Programs Agency (DARPA) SERS Science and Technology Fundamentals Program. The results presented are a snapshot of a collaborative effort between the US Army Edgewood Chemical Biological Center, and the US Army Research Laboratory-Aldelphi Laboratory Center to develop a quantitative analytical method with spectroscopic figures of merit to unambiguously compare the sensitivity and reproducibility of various SERS substrates submitted by the program participants. We present the design of a common assessment protocol and the definition of a SERS enhancement value (SEV) in order to effectively compare SERS active surfaces.

  6. 7 CFR 1783.8 - What are the acceptable methods for submitting applications?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false What are the acceptable methods for submitting applications? 1783.8 Section 1783.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) REVOLVING FUNDS FOR FINANCING WATER AND...

  7. Social Skills and Peer Acceptance: Effects of a Social Learning Method for Training Verbal Social Skills.

    ERIC Educational Resources Information Center

    Ladd, Gary W.

    The purpose of this study was to see if a social learning method for training verbal social skills might influence the social effectiveness of third grade children with low peer acceptance. Children were trained in three verbal skills: asking questions of peers; leading peers (e.g., offering useful suggestions or directions); and, offering…

  8. Readiness to accept Western standard of beauty and body satisfaction among Muslim girls with and without hijab.

    PubMed

    Đurović, Dušanka; Tiosavljević, Marija; Šabanović, Harisa

    2016-10-01

    The purpose of this paper was to determine whether there is a difference in the readiness to accept Western standards of beauty in which thinness is an ideal of beauty and attractiveness, as well in body and appearance satisfaction between Muslim adolescent girls attending madrassa and dressing in accordance with tradition, that is to say wearing hijab, and Muslim adolescent girls who do not wear hijab and who follow contemporary Western-influenced fashion trends. Both of these groups were also compared to a non-Muslim group of adolescent girls. The sample consisted of 75 Muslim adolescent girls with hijab, 75 Muslim adolescent girls without hijab and 75 Orthodox adolescent girls. The following instruments were used: the Eating Attitudes Test (EAT-26), the Sociocultural Attitudes towards Appearance Questionnaire (SATAQ-3) and the Contour Drawing Rating Scale (CDRS). The highest level of body satisfaction (despite this group having the highest body weight in the sample) was evident among Muslim adolescent girls attending madrassa and wearing hijab. They also showed significantly less pressure to attain the Western thin-ideal standards of beauty than adolescent girls who accept Western way of dressing. Research results indicate a significant role of socio-cultural factors in one's attitude towards the body image, but also opens the question of the role of religion as a protective factor when it comes to the body and appearance attitude among Muslim women who wear hijab.

  9. Readiness to accept Western standard of beauty and body satisfaction among Muslim girls with and without hijab.

    PubMed

    Đurović, Dušanka; Tiosavljević, Marija; Šabanović, Harisa

    2016-10-01

    The purpose of this paper was to determine whether there is a difference in the readiness to accept Western standards of beauty in which thinness is an ideal of beauty and attractiveness, as well in body and appearance satisfaction between Muslim adolescent girls attending madrassa and dressing in accordance with tradition, that is to say wearing hijab, and Muslim adolescent girls who do not wear hijab and who follow contemporary Western-influenced fashion trends. Both of these groups were also compared to a non-Muslim group of adolescent girls. The sample consisted of 75 Muslim adolescent girls with hijab, 75 Muslim adolescent girls without hijab and 75 Orthodox adolescent girls. The following instruments were used: the Eating Attitudes Test (EAT-26), the Sociocultural Attitudes towards Appearance Questionnaire (SATAQ-3) and the Contour Drawing Rating Scale (CDRS). The highest level of body satisfaction (despite this group having the highest body weight in the sample) was evident among Muslim adolescent girls attending madrassa and wearing hijab. They also showed significantly less pressure to attain the Western thin-ideal standards of beauty than adolescent girls who accept Western way of dressing. Research results indicate a significant role of socio-cultural factors in one's attitude towards the body image, but also opens the question of the role of religion as a protective factor when it comes to the body and appearance attitude among Muslim women who wear hijab. PMID:27477544

  10. Resourcefulness Training for Women Dementia Caregivers: Acceptability and Feasibility of Two Methods.

    PubMed

    Zauszniewski, Jaclene A; Lekhak, Nirmala; Napoleon, Betty; Morris, Diana L

    2016-01-01

    Almost 10 million women in the United States are caregivers for elders with dementia and many experience extreme stress that compromises their health. Acceptable and feasible interventions to teach them resourcefulness skills for managing stress may improve their health and facilitate continued caregiving. This study examined two commonly used methods for practicing skills taught during resourcefulness training (RT) to women caregivers of elders with dementia (n=63): journaling and digital voice recording. It also explored whether providing caregivers a choice between the two methods made it more acceptable or feasible. Qualitative and quantitative data were collected before, during, and after RT. Caregivers who recorded used more words (M=5446) but recorded fewer days (M=17) than those who journaled (M=2792 words and M=27 days). Similar concerns in relation to time management and practice method were expressed by women caregivers irrespective of practice method (journal versus recorder) or random versus choice condition. While journaling was more frequent than recording, more words were expressed during recordings. Perceived stress and depressive symptoms were unrelated to the number of practice days or word counts, suggesting RT acceptability and feasibility even for highly stressed or depressed caregivers. Because intervention feasibility is important for RT effectiveness testing, alternatives to the journaling and recording methods for practicing RT skills should be considered.

  11. Acceptability and Feasibility of Physical Activity Assessment Methods for an Appalachian Population

    PubMed Central

    Tarasenko, Yelena N.; Howell, Britteny M.; Studts, Christina R.; Strath, Scott J.; Schoenberg, Nancy E.

    2015-01-01

    Nowhere is improving understanding and accurate assessment of physical activity more important for disease prevention and health promotion than among health disparities populations such as those residing in rural and Appalachian regions. To enhance accurate assessment of physical activity and potentially improve intervention capacity, we conducted a mixed-methods study examining the acceptability and feasibility of self-report physical activity questionnaires, pedometers, and accelerometers among rural Appalachian children, adolescents, and adults. Most participants reported positive experiences with all three physical activity assessment tools. Several acceptability ratings differed by age group and by sex within each age group. With very few exceptions, no significant differences in acceptability were found by race, education, employment status, health status, BMI categories, income levels, or insurance status within age groups or overall. Several factors may impact the choice of the physical activity assessment method, including target population age, equipment cost, researcher burden, and potential influence on physical activity levels. Children and adolescents appear to have more constraints on when they can wear pedometers and accelerometers. While pedometers are inexpensive and convenient, they may influence physical activity levels, rather than simply measure them. Accelerometers, while less influential on behavior, consume extensive resources, including high purchase costs and researcher burden. PMID:25608476

  12. Acceptability and Feasibility of Physical Activity Assessment Methods for an Appalachian Population.

    PubMed

    Tarasenko, Yelena N; Howell, Britteny M; Studts, Christina R; Strath, Scott J; Schoenberg, Nancy E

    2015-08-01

    Nowhere is improving understanding and accurate assessment of physical activity more important for disease prevention and health promotion than among health disparities populations such as those residing in rural and Appalachian regions. To enhance accurate assessment of physical activity and potentially improve intervention capacity, we conducted a mixed-methods study examining the acceptability and feasibility of self-report physical activity questionnaires, pedometers, and accelerometers among rural Appalachian children, adolescents, and adults. Most participants reported positive experiences with all three physical activity assessment tools. Several acceptability ratings differed by age group and by sex within each age group. With very few exceptions, no significant differences in acceptability were found by race, education, employment status, health status, BMI categories, income levels, or insurance status within age groups or overall. Several factors may impact the choice of the physical activity assessment method, including target population age, equipment cost, researcher burden, and potential influence on physical activity levels. Children and adolescents appear to have more constraints on when they can wear pedometers and accelerometers. While pedometers are inexpensive and convenient, they may influence physical activity levels, rather than simply measure them. Accelerometers, while less influential on behavior, consume extensive resources, including high purchase costs and researcher burden.

  13. 75 FR 65052 - Consensus Standards, Standard Practice for Maintenance of Airplane Electrical Wiring Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... TRANSPORTATION Federal Aviation Administration Consensus Standards, Standard Practice for Maintenance of Airplane... Practice for Maintenance of Airplane Electrical Wiring Systems (Standard Practice) as an acceptable means... FAA finds the standards to be acceptable methods and procedures for maintenance of electrical...

  14. LEARNING STANDARD ENGLISH BY LINGUISTIC METHODS.

    ERIC Educational Resources Information Center

    GOLDEN, RUTH I.

    THE AUTHOR, WHO SPENT A YEAR AS A FORD FELLOW STUDYING THE NON-STANDARD ENGLISH OF STUDENTS IN DETROIT, DESCRIBES BRIEFLY A SERIES OF TAPED LANGUAGE LESSONS FOR SECONDARY LEVEL WHICH WERE FOUND TO BE "EFFECTIVE TO A SIGNIFICANT DEGREE." (SEE RELATED DOCUMENT ED 003 588.) FURTHER EXPERIMENTATION WAS CARRIED OUT ON THE FIRST LEVEL OF PRIMARY SCHOOL,…

  15. TEM calibration methods for critical dimension standards

    NASA Astrophysics Data System (ADS)

    Orji, Ndubuisi G.; Dixson, Ronald G.; Garcia-Gutierrez, Domingo I.; Bunday, Benjamin D.; Bishop, Michael; Cresswell, Michael W.; Allen, Richard A.; Allgair, John A.

    2007-03-01

    One of the key challenges in critical dimension (CD) metrology is finding suitable calibration standards. Over the last few years there has been some interest in using features measured with the transmission electron microscope (TEM) as primary standards for linewidth measurements. This is because some modes of TEM can produce lattice-resolved images having scale traceability to the SI (Systeme International d'Unites or International System of Units) definition of length through an atomic lattice constant. As interest in using calibration samples that are closer to the length scales being measured increases, so will the use of these TEM techniques. An area where lattice-traceable images produced by TEM has been used as a primary standard is in critical dimension atomic force microscope (CD-AFM) tip width calibration. Two modes of TEM that produce crystal lattice-traceable images are high resolution transmission electron microscope (HR-TEM) and high angle annular dark field scanning transmission electron microscope (HAADF-STEM). HR-TEM produces lattice-traceable images by interference patterns of the diffracted and transmitted beams rather than the actual atomic columns, while HAADF-STEM produces direct images of the crystal lattice. The difference in how both of these techniques work could cause subtle variations in the way feature edges are defined. In this paper, we present results from width samples measured using HR-TEM and HAADF-STEM. Next we compare the results with measurements taken from the same location by two different CD-AFMs. Both of the CD-AFM instruments used for this work have been calibrated using a single crystal critical dimension reference material (SCCDRM). These standards, developed by the National Institute of Standards and Technology (NIST) and SEMATECH, used HR-TEM for traceable tip-width calibration. Consequently, the present work and the previous SCCDRM work provide a mutual cross-check on the traceability of the width calibration

  16. 41 CFR 304-6.9 - Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate... Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate or...

  17. 41 CFR 304-6.9 - Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate... Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate or...

  18. 41 CFR 304-6.9 - Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false Does acceptance by OGE of the Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate... Standard Form (SF) 326 constitute a determination by OGE that the data submitted is adequate or...

  19. Validation of analytical methods involved in dissolution assays: acceptance limits and decision methodologies.

    PubMed

    Rozet, E; Ziemons, E; Marini, R D; Boulanger, B; Hubert, Ph

    2012-11-01

    Dissolution tests are key elements to ensure continuing product quality and performance. The ultimate goal of these tests is to assure consistent product quality within a defined set of specification criteria. Validation of an analytical method aimed at assessing the dissolution profile of products or at verifying pharmacopoeias compliance should demonstrate that this analytical method is able to correctly declare two dissolution profiles as similar or drug products as compliant with respect to their specifications. It is essential to ensure that these analytical methods are fit for their purpose. Method validation is aimed at providing this guarantee. However, even in the ICHQ2 guideline there is no information explaining how to decide whether the method under validation is valid for its final purpose or not. Are the entire validation criterion needed to ensure that a Quality Control (QC) analytical method for dissolution test is valid? What acceptance limits should be set on these criteria? How to decide about method's validity? These are the questions that this work aims at answering. Focus is made to comply with the current implementation of the Quality by Design (QbD) principles in the pharmaceutical industry in order to allow to correctly defining the Analytical Target Profile (ATP) of analytical methods involved in dissolution tests. Analytical method validation is then the natural demonstration that the developed methods are fit for their intended purpose and is not any more the inconsiderate checklist validation approach still generally performed to complete the filing required to obtain product marketing authorization. PMID:23084050

  20. Standard Methods for Unnotched Tension Testing of Textile Composites

    NASA Technical Reports Server (NTRS)

    Portanova, M. A.

    1995-01-01

    An investigation was conducted by researchers at the Boeing Defense & Space Group to investigate the effects of specimen sizing on several braided textile materials. Test results from this and other test programs were compared in an effort to determine what effect, if any, specimen size has on elastic property measurements of unnotched tension test. In general, the unnotched tensile strength of 2-D braids was found to be insensitive to specimen width, length, or thickness effects. The results from this study suggest that standard testing methods used for tape materials may be sufficient for tension testing of textile composite materials. Specifically, the straight sided specimen geometry described in ASTM 3034, and used by Boeing, should provide acceptable results. Further experiments performed at Boeing and by other investigators on other textile architectures suggest similar results. Although specimen size studies were not conducted, failing stresses varied on the same order as those obtained with the 2-D materials. This suggests that the accuracy of the results were consistent with those obtained with the 2-D materials.

  1. Acceptance of routine or case-based inquiry for intimate partner violence: a mixed method study

    PubMed Central

    2013-01-01

    Background The prevalence and detrimental health effects of intimate partner violence have resulted in international discussions and recommendations that health care professionals should screen women for intimate partner violence during general and antenatal health care visits. Due to the lack of discussion on routine or case-based inquiry for intimate partner violence during antenatal care in Germany, this study seeks to explore its acceptability among pregnant German women. Methods A mixed methods approach was used, utilizing a self-administered survey on the acceptability of routine or case-based inquiry for intimate partner violence in a university hospital’s maternity ward in Munich and in-depth interviews with seven women who experienced violence during pregnancy. Results Of the 401 women who participated in the survey, 92 percent were in favor of routine or case-based inquiry for intimate partner violence during antenatal care. Acceptance of routine or case-based inquiry for intimate partner violence during antenatal care was significantly associated with women’s experiences of child sexual abuse, being young, less educated, single or divorced and smoking during pregnancy. Open-ended survey questions and in-depth interviews stressed adequate training for screening, sufficient time and provision of referral information as important conditions for routine or case-based inquiry for intimate partner violence. Conclusions Women in this study showed an overwhelming support for routine or case-based screening for intimate partner violence in antenatal care in Germany. Until adequate training is in place to allow providers to inquire for intimate partner violence in a professional manner, this study recommends that health care providers are made aware of the prevalence and health consequences of violence during pregnancy. PMID:23531127

  2. Methods for verifying compliance with low-level radioactive waste acceptance criteria

    SciTech Connect

    1993-09-01

    This report summarizes the methods that are currently employed and those that can be used to verify compliance with low-level radioactive waste (LLW) disposal facility waste acceptance criteria (WAC). This report presents the applicable regulations representing the Federal, State, and site-specific criteria for accepting LLW. Typical LLW generators are summarized, along with descriptions of their waste streams and final waste forms. General procedures and methods used by the LLW generators to verify compliance with the disposal facility WAC are presented. The report was written to provide an understanding of how a regulator could verify compliance with a LLW disposal facility`s WAC. A comprehensive study of the methodology used to verify waste generator compliance with the disposal facility WAC is presented in this report. The study involved compiling the relevant regulations to define the WAC, reviewing regulatory agency inspection programs, and summarizing waste verification technology and equipment. The results of the study indicate that waste generators conduct verification programs that include packaging, classification, characterization, and stabilization elements. The current LLW disposal facilities perform waste verification steps on incoming shipments. A model inspection and verification program, which includes an emphasis on the generator`s waste application documentation of their waste verification program, is recommended. The disposal facility verification procedures primarily involve the use of portable radiological survey instrumentation. The actual verification of generator compliance to the LLW disposal facility WAC is performed through a combination of incoming shipment checks and generator site audits.

  3. Personalized Medicine in the U.S. and Germany: Awareness, Acceptance, Use and Preconditions for the Wide Implementation into the Medical Standard

    PubMed Central

    Kichko, Kateryna; Marschall, Paul; Flessa, Steffen

    2016-01-01

    The aim of our research was to collect comprehensive data about the public and physician awareness, acceptance and use of Personalized Medicine (PM), as well as their opinions on PM reimbursement and genetic privacy protection in the U.S. and Germany. In order to give a better overview, we compared our survey results with the results from other studies and discussed Personalized Medicine preconditions for its wide implementation into the medical standard. For the data collection, using the same methodology, we performed several surveys in Pennsylvania (U.S.) and Bavaria (Germany). Physicians were contacted via letter, while public representatives in person. Survey results, analyzed by means of descriptive and non-parametric statistic methods, have shown that awareness, acceptance, use and opinions on PM aspects in Pennsylvania and Bavaria were not significantly different. In both states there were strong concerns about genetic privacy protection and no support of one genetic database. The costs for Personalized Medicine were expected to be covered by health insurances and governmental funds. Summarizing, we came to the conclusion that for PM wide implementation there will be need to adjust the healthcare reimbursement system, as well as adopt new laws which protect against genetic misuse and simultaneously enable voluntary data provision. PMID:27144585

  4. Development of test acceptance standards for qualification of the glass-bonded zeolite waste form. Interim annual report, October 1995--September 1996

    SciTech Connect

    Simpson, L.J.; Wronkiewicz, D.J.; Fortner, J.A.

    1997-09-01

    Glass-bonded zeolite is being developed at Argonne National Laboratory in the Electrometallurgical Treatment Program as a potential ceramic waste form for the disposition of radionuclides associated with the US Department of Energy`s (DOE`s) spent nuclear fuel conditioning activities. The utility of standard durability tests [e.g. Materials Characterization Center Test No. 1 (MCC-1), Product Consistency Test (PCT), and Vapor Hydration Test (VHT)] are being evaluated as an initial step in developing test methods that can be used in the process of qualifying this material for acceptance into the Civilian Radioactive Waste Management System. A broad range of potential repository conditions are being evaluated to determine the bounding parameters appropriate for the corrosion testing of the ceramic waste form, and its behavior under accelerated testing conditions. In this report we provide specific characterization information and discuss how the durability test results are affected by changes in pH, leachant composition, and sample surface area to leachant volume ratios. We investigate the release mechanisms and other physical and chemical parameters that are important for establishing acceptance parameters, including the development of appropriate test methodologies required to measure product consistency.

  5. Method for Constructing Standardized Simulated Root Canals.

    ERIC Educational Resources Information Center

    Schulz-Bongert, Udo; Weine, Franklin S.

    1990-01-01

    The construction of visual and manipulative aids, clear resin blocks with root-canal-like spaces, for simulation of root canals is explained. Time, materials, and techniques are discussed. The method allows for comparison of canals, creation of any configuration of canals, and easy presentation during instruction. (MSE)

  6. Standardized Radiation Shield Design Methods: 2005 HZETRN

    NASA Technical Reports Server (NTRS)

    Wilson, John W.; Tripathi, Ram K.; Badavi, Francis F.; Cucinotta, Francis A.

    2006-01-01

    Research committed by the Langley Research Center through 1995 resulting in the HZETRN code provides the current basis for shield design methods according to NASA STD-3000 (2005). With this new prominence, the database, basic numerical procedures, and algorithms are being re-examined with new methods of verification and validation being implemented to capture a well defined algorithm for engineering design processes to be used in this early development phase of the Bush initiative. This process provides the methodology to transform the 1995 HZETRN research code into the 2005 HZETRN engineering code to be available for these early design processes. In this paper, we will review the basic derivations including new corrections to the codes to insure improved numerical stability and provide benchmarks for code verification.

  7. A Mixed-methods Evaluation of the Feasibility, Acceptability and Preliminary Efficacy of a Mobile Intervention for Methadone Maintenance Clients

    PubMed Central

    Guarino, Honoria; Acosta, Michelle; Marsch, Lisa A.; Xie, Haiyi; Aponte-Melendez, Yesenia

    2015-01-01

    Despite the recent explosion of behavioral health interventions delivered on mobile devices, little is known about factors that make such applications practical, engaging and useful to their target audience. This study reports on the feasibility, acceptability and preliminary efficacy of a prototype of a novel, interactive mobile psychosocial intervention to reduce problematic drug use among clients in methadone maintenance treatment (MMT). A mixed-methods pilot study with new MMT clients (n=25) indicated that the mobile intervention approach was feasible, and that participants found the intervention highly acceptable and useful. On 100-point visual analog scale (VAS) items, participants reported high levels of liking the program (M=75.6), and endorsed it as useful (M=77.5), easy to use (M=80.7), and containing a significant amount of new information (M=74.8). When compared with 25 study participants who received standard MMT alone, pilot participants rated their treatment significantly higher in interestingness and usefulness, and were significantly more satisfied with their treatment. In qualitative interviews, participants reported using the mobile intervention in a range of settings, including during times of heightened risk for substance use, and finding it helpful in managing drug cravings. Additionally, pilot participants showed evidence of increased treatment retention and abstinence from illicit opioids (in terms of effect size) over a 3-month period relative to those in standard MMT, suggesting the application’s potential to enhance treatment outcomes. These promising findings suggest that an evidence-based mobile therapeutic tool addressing substance use may appeal to drug treatment clients and have clinical utility as an adjunct to formal treatment. PMID:26618796

  8. A mixed-methods evaluation of the feasibility, acceptability, and preliminary efficacy of a mobile intervention for methadone maintenance clients.

    PubMed

    Guarino, Honoria; Acosta, Michelle; Marsch, Lisa A; Xie, Haiyi; Aponte-Melendez, Yesenia

    2016-02-01

    Despite the recent explosion of behavioral health interventions delivered on mobile devices, little is known about factors that make such applications practical, engaging and useful to their target audience. This study reports on the feasibility, acceptability and preliminary efficacy of a prototype of a novel, interactive mobile psychosocial intervention to reduce problematic drug use among clients in methadone maintenance treatment (MMT). A mixed-methods pilot study with new MMT clients (n = 25) indicated that the mobile intervention approach was feasible, and that participants found the intervention highly acceptable and useful. On 100-point visual analog scale (VAS) items, participants reported high levels of liking the program (M = 75.6), and endorsed it as useful (M = 77.5), easy to use (M = 80.7), and containing a significant amount of new information (M = 74.8). When compared with 25 study participants who received standard MMT alone, pilot participants rated their treatment significantly higher in interestingness and usefulness, and were significantly more satisfied with their treatment. In qualitative interviews, participants reported using the mobile intervention in a range of settings, including during times of heightened risk for substance use, and finding it helpful in managing drug cravings. Additionally, pilot participants showed evidence of increased treatment retention and abstinence from illicit opioids (in terms of effect size) over a 3-month period relative to those in standard MMT, suggesting the application's potential to enhance treatment outcomes. These promising findings suggest that an evidence-based mobile therapeutic tool addressing substance use may appeal to drug treatment clients and have clinical utility as an adjunct to formal treatment.

  9. Life coaching following haematopoietic stem cell transplantation: a mixed-method investigation of feasibility and acceptability.

    PubMed

    Kenyon, M; Young, F; Mufti, G J; Pagliuca, A; Lim, Z; Ream, E

    2015-07-01

    Haematopoietic stem cell transplantation (HSCT) cures many haematological cancers. Recovery post-HSCT is physically and psychologically challenging, lasting several months. Beyond the first post-transplant year, a fifth report difficulties encompassing practical, social and emotional domains, including finance and employment. We investigated the feasibility, acceptability and impact of a life coaching intervention designed to address psychosocial 'survivor' concerns of HSCT recipients and facilitate transition to life post-treatment. A concurrent embedded experimental mixed-method design was employed. Pre- and post-intervention data collection comprised qualitative semi-structured telephone interviews and quantitative postal questionnaires. Seven purposively sampled HSCT recipients (<18 months) participated, reporting on one-to-one life coaching delivered by a professional life coach fortnightly over 8 weeks. Participants reported less anxiety, depression and fewer survivor concerns post-intervention, with a trend for lower social difficulties and increased functional well-being. Perceived self-efficacy was unchanged. Life coaching was feasible to deliver and acceptable to the participants who indicated it was a positive experience, with benefits described in diverse areas including work, lifestyle and hobbies. Life coaching within cancer services potentially offers the means to address psychosocial concerns and support transition to life after treatment, enabling patients to reach their potential, e.g. returning to employment and financial independence. Further investigation of this intervention in cancer survivors is warranted.

  10. Gravimetry with Quantum Methods and Quantum Standards

    NASA Astrophysics Data System (ADS)

    Flury, J.

    2015-12-01

    Quantum metrology enables new methods for measuring gravitational quantities. Currently, significant progress in the development of quantum gravimeters, quantum optical clocks, and optical frequency transfer is underway. Quantum gravimeters use a variety of techniques to determine the gravity acceleration acting on clouds of atoms with coherent matter wave phase. We discuss configurations with very small and very large trajectories. Optical atomic clocks and optical frequency transfer allow the determination of gravity potential differences through the gravitational frequency redshift. Recent progress in clock development and in frequency transfer through optical fiber is leading to results with high relevance for geodesy. First experiments for long distance clock comparisons and chronometric leveling are underway. Concepts for geodetic modeling with relativistic quantities are being investigated.

  11. Standard methods for sampling North American freshwater fishes

    USGS Publications Warehouse

    Bonar, Scott A.; Hubert, Wayne A.; Willis, David W.

    2009-01-01

    This important reference book provides standard sampling methods recommended by the American Fisheries Society for assessing and monitoring freshwater fish populations in North America. Methods apply to ponds, reservoirs, natural lakes, and streams and rivers containing cold and warmwater fishes. Range-wide and eco-regional averages for indices of abundance, population structure, and condition for individual species are supplied to facilitate comparisons of standard data among populations. Provides information on converting nonstandard to standard data, statistical and database procedures for analyzing and storing standard data, and methods to prevent transfer of invasive species while sampling.

  12. Standard methods for fungal brood disease research

    PubMed Central

    Jensen, Annette Bruun; Aronstein, Kathrine; Flores, José Manuel; Vojvodic, Svjetlana; Palacio, María Alejandra; Spivak, Marla

    2013-01-01

    Summary Chalkbrood and stonebrood are two fungal diseases associated with honey bee brood. Chalkbrood, caused by Ascosphaera apis, is a common and widespread disease that can result in severe reduction of emerging worker bees and thus overall colony productivity. Stonebrood is caused by Aspergillus spp. that are rarely observed, so the impact on colony health is not very well understood. A major concern with the presence of Aspergillus in honey bees is the production of airborne conidia, which can lead to allergic bronchopulmonary aspergillosis, pulmonary aspergilloma, or even invasive aspergillosis in lung tissues upon inhalation by humans. In the current chapter we describe the honey bee disease symptoms of these fungal pathogens. In addition, we provide research methodologies and protocols for isolating and culturing, in vivo and in vitro assays that are commonly used to study these host pathogen interactions. We give guidelines on the preferred methods used in current research and the application of molecular techniques. We have added photographs, drawings and illustrations to assist bee-extension personnel and bee scientists in the control of these two diseases. PMID:24198438

  13. Standardization of shape memory alloy test methods toward certification of aerospace applications

    NASA Astrophysics Data System (ADS)

    Hartl, D. J.; Mabe, J. H.; Benafan, O.; Coda, A.; Conduit, B.; Padan, R.; Van Doren, B.

    2015-08-01

    The response of shape memory alloy (SMA) components employed as actuators has enabled a number of adaptable aero-structural solutions. However, there are currently no industry or government-accepted standardized test methods for SMA materials when used as actuators and their transition to commercialization and production has been hindered. This brief fast track communication introduces to the community a recently initiated collaborative and pre-competitive SMA specification and standardization effort that is expected to deliver the first ever regulatory agency-accepted material specification and test standards for SMA as employed as actuators for commercial and military aviation applications. In the first phase of this effort, described herein, the team is working to review past efforts and deliver a set of agreed-upon properties to be included in future material certification specifications as well as the associated experiments needed to obtain them in a consistent manner. Essential for the success of this project is the participation and input from a number of organizations and individuals, including engineers and designers working in materials and processing development, application design, SMA component fabrication, and testing at the material, component, and system level. Going forward, strong consensus among this diverse body of participants and the SMA research community at large is needed to advance standardization concepts for universal adoption by the greater aerospace community and especially regulatory bodies. It is expected that the development and release of public standards will be done in collaboration with an established standards development organization.

  14. Probabilistic Requirements (Partial) Verification Methods Best Practices Improvement. Variables Acceptance Sampling Calculators: Derivations and Verification of Plans. Volume 1

    NASA Technical Reports Server (NTRS)

    Johnson, Kenneth L.; White, K, Preston, Jr.

    2012-01-01

    The NASA Engineering and Safety Center was requested to improve on the Best Practices document produced for the NESC assessment, Verification of Probabilistic Requirements for the Constellation Program, by giving a recommended procedure for using acceptance sampling by variables techniques. This recommended procedure would be used as an alternative to the potentially resource-intensive acceptance sampling by attributes method given in the document. This document contains the outcome of the assessment.

  15. A Comparative Study of Standard-Setting Methods.

    ERIC Educational Resources Information Center

    Livingston, Samuel A.; Zieky, Michael J.

    1989-01-01

    The borderline group standard-setting method (BGSM), Nedelsky method (NM), and Angoff method (AM) were compared, using reading scores for 1,948 and mathematics scores for 2,191 sixth through ninth graders. The NM and AM were inconsistent with the BGSM. Passing scores were higher where students were more able. (SLD)

  16. A Comparison of Bookmark and Angoff Standard Setting Methods

    ERIC Educational Resources Information Center

    Çetin, Sevda; Gelbal, Selahattin

    2013-01-01

    In this research, the cut score of a foundation university was re-calculated with bookmark method and with Angoff method, each of which is a standard setting method; and the cut scores found were compared with the current proficiency score. Thus, the final cut score was found to be 27.87 with the cooperative work of 17 experts through the Angoff…

  17. Comparison of Saliva Collection Methods in Children with High-Functioning Autism Spectrum Disorders: Acceptability and Recovery of Cortisol

    ERIC Educational Resources Information Center

    Putnam, Susan K.; Lopata, Christopher; Fox, Jeffery D.; Thomeer, Marcus L.; Rodgers, Jonathan D.; Volker, Martin A.; Lee, Gloria K.; Neilans, Erik G.; Werth, Jilynn

    2012-01-01

    This study compared cortisol concentrations yielded using three saliva collection methods (passive drool, salivette, and sorbette) in both in vitro and in vivo conditions, as well as method acceptability for a sample of children (n = 39) with High Functioning Autism Spectrum Disorders. No cortisol concentration differences were observed between…

  18. Influence of ethnicity on acceptability of method of blood pressure monitoring: a cross-sectional study in primary care

    PubMed Central

    Wood, Sally; Greenfield, Sheila M; Sayeed Haque, M; Martin, Una; Gill, Paramjit S; Mant, Jonathan; Mohammed, Mohammed A; Heer, Gurdip; Johal, Amanpreet; Kaur, Ramandeep; Schwartz, Claire; McManus, Richard J

    2016-01-01

    Background Ambulatory and/or home monitoring are recommended in the UK and the US for the diagnosis of hypertension but little is known about their acceptability. Aim To determine the acceptability of different methods of measuring blood pressure to people from different minority ethnic groups. Design and setting Cross-sectional study with focus groups in primary care in the West Midlands. Method People of different ethnicities with and without hypertension were assessed for acceptability of clinic, home, and ambulatory blood pressure measurement using completion rate, questionnaire, and focus groups. Results A total of 770 participants were included, who were white British (n = 300), South Asian (n = 241), and African Caribbean (n = 229). White British participants had significantly higher successful completion rates across all monitoring modalities compared with the other ethnic groups, especially for ambulatory monitoring: white British (n = 277, 92% [95% confidence interval [CI] = 89% to 95%]) versus South Asian (n = 171, 71% [95% CI = 65% to 76%], P<0.001) and African Caribbean (n = 188, 82% [95% CI = 77% to 87%], P<0.001), respectively. There were significantly lower acceptability scores for minority ethnic participants across all monitoring methods compared with white British participants. Focus group results highlighted self-monitoring as most acceptable and ambulatory monitoring least acceptable without consistent differences by ethnicity. Clinic monitoring was seen as inconvenient and anxiety provoking but with the advantage of immediate professional input. Conclusion Reduced acceptability and completion rates among minority ethnic groups raise important questions for the implementation and interpretation of blood pressure monitoring. Selection of method of blood pressure monitoring should take into account clinical need, patient preference, and potential cultural barriers to monitoring. PMID:27266860

  19. Formaldehyde emission—Comparison of different standard methods

    NASA Astrophysics Data System (ADS)

    Risholm-Sundman, Maria; Larsen, Annelise; Vestin, Ewa; Weibull, Anders

    The emission of formaldehyde is an important factor in the evaluation of the environmental and health effects of wood-based board materials. This article gives a comparison between commonly used European test methods: chamber method [EN 717-1, 2004. Wood-based panels—determination of formaldehyde release—Part 1: formaldehyde emission by the chamber method. European Standard, October 2004], gas analysis method [EN 717-2, 1994. Wood-based panels—determination of formaldehyde release—Part 2: formaldehyde release by the gas analysis method, European Standard, November 1994], flask method [EN 717-3, 1996. Wood-based panels—determination of formaldehyde release—Part 3: formaldehyde release by the flask method, European Standard, March 1996], perforator method [EN 120, 1993. Wood based panels—determination of formaldehyde content—extraction method called perforator method, European Standard, September 1993], Japanese test methods: desiccator methods [JIS A 1460, 2001. Building boards. Determination of formaldehyde emission—desiccator method, Japanese Industrial Standard, March 2001 and JAS MAFF 233, 2001] and small chamber method [JIS A 1901, 2003. Determination of the emission of volatile organic compounds and aldehydes for building products—small chamber method, Japanese Industrial Standard, January 2003], for solid wood, particleboard, plywood and medium density fiberboard. The variations between the results from different methods can partly be explained by differences in test conditions. Factors like edge sealing, conditioning of the sample before the test and test temperature have a large effect on the final emission result. The Japanese limit for F **** of 0.3 mg l -1 (in desiccator) for particleboards was found to be equivalent to 0.04 mg m -3 in the European chamber test and 2.8 mg per 100 g in the perforator test. The variations in inter-laboratory tests are much larger than in intra-laboratory tests; the coefficient of variation is 16% and 6

  20. Breast pumps as an incentive for breastfeeding: a mixed methods study of acceptability.

    PubMed

    Crossland, Nicola; Thomson, Gill; Morgan, Heather; MacLennan, Graeme; Campbell, Marion; Dykes, Fiona; Hoddinott, Pat

    2016-10-01

    Increasing breastfeeding rates would improve maternal and child health, but multiple barriers to breastfeeding persist. Breast pump provision has been used as an incentive for breastfeeding, although effectiveness is unclear. Women's use of breast pumps is increasing and a high proportion of mothers express breastmilk. No research has yet reported women's and health professionals' perspectives on breast pumps as an incentive for breastfeeding. In the Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS) study, mixed methods research explored women's and professionals' views of breast pumps as an incentive for breastfeeding. A survey of health professionals across Scotland and North West England measured agreement with 'a breast pump costing around £40 provided for free on the NHS' as an incentive strategy. Qualitative interviews and focus groups were conducted in two UK regions with a total of 68 participants (pregnant women, new mothers, and their significant others and health professionals) and thematic analysis undertaken. The survey of 497 health professionals found net agreement of 67.8% (337/497) with the breast pump incentive strategy, with no predictors of agreement shown by a multiple ordered logistic regression model. Qualitative research found interrelated themes of the 'appeal and value of breast pumps', 'sharing the load', 'perceived benefits', 'perceived risks' and issues related to 'timing'. Qualitative participants expressed mixed views on the acceptability of breast pumps as an incentive for breastfeeding. Understanding the mechanisms of action for pump type, timing and additional support required for effectiveness is required to underpin trials of breast pump provision as an incentive for improving breastfeeding outcomes. © 2016 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.

  1. Breast pumps as an incentive for breastfeeding: a mixed methods study of acceptability.

    PubMed

    Crossland, Nicola; Thomson, Gill; Morgan, Heather; MacLennan, Graeme; Campbell, Marion; Dykes, Fiona; Hoddinott, Pat

    2016-10-01

    Increasing breastfeeding rates would improve maternal and child health, but multiple barriers to breastfeeding persist. Breast pump provision has been used as an incentive for breastfeeding, although effectiveness is unclear. Women's use of breast pumps is increasing and a high proportion of mothers express breastmilk. No research has yet reported women's and health professionals' perspectives on breast pumps as an incentive for breastfeeding. In the Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS) study, mixed methods research explored women's and professionals' views of breast pumps as an incentive for breastfeeding. A survey of health professionals across Scotland and North West England measured agreement with 'a breast pump costing around £40 provided for free on the NHS' as an incentive strategy. Qualitative interviews and focus groups were conducted in two UK regions with a total of 68 participants (pregnant women, new mothers, and their significant others and health professionals) and thematic analysis undertaken. The survey of 497 health professionals found net agreement of 67.8% (337/497) with the breast pump incentive strategy, with no predictors of agreement shown by a multiple ordered logistic regression model. Qualitative research found interrelated themes of the 'appeal and value of breast pumps', 'sharing the load', 'perceived benefits', 'perceived risks' and issues related to 'timing'. Qualitative participants expressed mixed views on the acceptability of breast pumps as an incentive for breastfeeding. Understanding the mechanisms of action for pump type, timing and additional support required for effectiveness is required to underpin trials of breast pump provision as an incentive for improving breastfeeding outcomes. © 2016 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. PMID:27502101

  2. BSAC standardized disc susceptibility testing method (version 11).

    PubMed

    Howe, R A; Andrews, J M

    2012-12-01

    This article highlights key amendments incorporated into version 11 of the BSAC standardized disc susceptibility testing method, available as Supplementary data at JAC Online (http://jac.oxfordjournals.org/) and on the BSAC web site (http://bsac.org.uk/susceptibility/guidelines-standardized-disc-susceptibility-testing-method/). The basic disc susceptibility testing method remains unchanged, but there have been a number of alterations to the interpretive criteria for certain organism/drug combinations due to continuing harmonization with the EUCAST MIC breakpoints and constant efforts to improve the reliability and clinical applicability of the guidance.

  3. Standardization of Sm-153 solution by absolute methods.

    PubMed

    Dziel, T; Broda, R; Ziemek, T; Muklanowicz, A; Listkowska, A

    2014-05-01

    Standardization of (153)Sm by 4π(LS)-γ coincidence and anticoincidence counting and the CIEMAT/NIST method in three LS-counters is presented. This short half-life radionuclide is applied in tumor therapy and bone pain palliation. A simplified disintegration scheme of (153)Sm was applied in the calculation of the counting efficiency. Standard uncertainties of 0.4% for the (153)Sm measurements by the 4π(LS)-γ coincidence and anticoincidence techniques and 0.7% by the C/N method were evaluated, respectively. An agreement of the standardization results by both methods within the respective uncertainties was obtained. The half-life of (153)Sm of (1.92895±0.00024) days was determined during one month of measurements and correction for europium isotope impurities by the C/N method in the TriCarb 2910 LS-counter.

  4. Standardization of 65Zn by sum-peak method.

    PubMed

    Oliveira, E M; Iwahara, A; Poledna, R; Delgado, J U; da Silva, C J; da Silva, R L; Lopes, R T

    2012-09-01

    A commercial solution of (65)Zn was standardized by the sum peak-method using a planar HPGe detector. The activity results were compared with measurements made with a well type 4πγ ionization chamber, which is traceable to BIPM.RI (II)-K2.Zn-65 key-comparison performed in 2002. The sum-peak value was 42.79 kBq/g and the ionization chamber value was 42.74 kBq/g both at the reference date. The uncertainty obtained in the sum peak standardization was 0.25% (k=1), and in the ionization chamber was 0.85% (k=1). The results showed that sum-peak method can be used in (65)Zn standardization and this method is easier, simpler and more practical than others methods. PMID:22425414

  5. Optimal Multicomponent Analysis Using the Generalized Standard Addition Method.

    ERIC Educational Resources Information Center

    Raymond, Margaret; And Others

    1983-01-01

    Describes an experiment on the simultaneous determination of chromium and magnesium by spectophotometry modified to include the Generalized Standard Addition Method computer program, a multivariate calibration method that provides optimal multicomponent analysis in the presence of interference and matrix effects. Provides instructions for…

  6. 49 CFR 1200.2 - Adoption of generally accepted accounting principles issued by the Financial Accounting Standards...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Financial Accounting Standards by the FASB, and provided that the Office of Economics, Environmental... regulations, the Office of Economics, Environmental Analysis, and Administration shall issue an Accounting... the Uniform Systems of Accounts, (49 CFR 1201 through 1210). (d) Accounting Standards Not...

  7. 49 CFR 1200.2 - Adoption of generally accepted accounting principles issued by the Financial Accounting Standards...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Financial Accounting Standards by the FASB, and provided that the Office of Economics, Environmental... regulations, the Office of Economics, Environmental Analysis, and Administration shall issue an Accounting... the Uniform Systems of Accounts, (49 CFR 1201 through 1210). (d) Accounting Standards Not...

  8. 49 CFR 1200.2 - Adoption of generally accepted accounting principles issued by the Financial Accounting Standards...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Financial Accounting Standards by the FASB, and provided that the Office of Economics, Environmental... regulations, the Office of Economics, Environmental Analysis, and Administration shall issue an Accounting... the Uniform Systems of Accounts, (49 CFR 1201 through 1210). (d) Accounting Standards Not...

  9. 49 CFR 1200.2 - Adoption of generally accepted accounting principles issued by the Financial Accounting Standards...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Financial Accounting Standards by the FASB, and provided that the Office of Economics, Environmental... regulations, the Office of Economics, Environmental Analysis, and Administration shall issue an Accounting... the Uniform Systems of Accounts, (49 CFR 1201 through 1210). (d) Accounting Standards Not...

  10. 49 CFR 1200.2 - Adoption of generally accepted accounting principles issued by the Financial Accounting Standards...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Financial Accounting Standards by the FASB, and provided that the Office of Economics, Environmental... regulations, the Office of Economics, Environmental Analysis, and Administration shall issue an Accounting... the Uniform Systems of Accounts, (49 CFR 1201 through 1210). (d) Accounting Standards Not...

  11. Gravimetric methods for the preparation of standard gas mixtures

    NASA Astrophysics Data System (ADS)

    Milton, M. J. T.; Vargha, G. M.; Brown, A. S.

    2011-10-01

    The most widely used method for the preparation of primary standard gas mixtures involves weighing the individual components into a cylinder. We present a new mathematical description of the method and its uncertainties. We use this to demonstrate how strategies for serial dilution can be identified that minimize the uncertainty in the final mixture and show how they can be implemented practically. We review published reports of high accuracy gravimetry and give examples of relative uncertainties in the composition of standards approaching 1 part-per-million in the best cases and in the range of 100 to 1000 parts-per-million more typically.

  12. Adjunct Methods of the Standard Diabetic Foot Ulceration Therapy

    PubMed Central

    Waniczek, Dariusz; Kozowicz, Andrzej; Kokot, Teresa; Świętochowska, Elżbieta; Nowakowska-Zajdel, Ewa

    2013-01-01

    The outcome of management of diabetic foot ulceration (DFU) is poor and insufficient. DFU therapy includes the standard management as debridement of the wound, revascularization procedures, off-loading of the ulcer and antibacterial actions, and supplementation of growth factors and cytokines, leading to stimulation of granulation, epidermization, and angiogenesis. The aim of the present review is to summarize the adjunct methods of the standard DFU therapy as hyperbaric oxygen therapy (HBOT), maggot therapy (MT), and platelet-rich plasma therapy (PRPT). The results of preclinical and clinical trials indicated that the methods may reduce time of therapy, short-term morbidity, and the risk of major amputation. PMID:23843866

  13. The seven Cs of the high acceptability of home-based VCT: results from a mixed methods approach in Zambia.

    PubMed

    Jürgensen, Marte; Sandøy, Ingvild F; Michelo, Charles; Fylkesnes, Knut; Mwangala, Sheila; Blystad, Astrid

    2013-11-01

    HIV testing and counselling is a critical gateway to prevention and treatment. Yet, coverage remains insufficient, few couples are tested together and gender differences in access exist. We used an embedded mixed methods approach to investigate possible explanations for the high acceptance of home-based voluntary HIV counselling and testing (HB-VCT) in a pair-matched cluster-randomized trial in Zambia. A baseline survey included 1694 individuals in 36 clusters. Adults in 18 intervention clusters were offered HB-VCT by lay counsellors. Standard testing services were available in both trial arms. After the completion of the intervention, a follow-up survey was conducted in all trial clusters. In addition, 21 in-depth interviews and one focus group discussion were conducted with home-based VCT clients in the intervention arm. Informants favoured the convenience, confidentiality and credibility of HB-VCT. Counsellors were perceived as trustworthy owing to their closeness and conduct, and the consent process was experienced as convincing. Couple testing was selected by 70% of cohabiting couples and was experienced as beneficial by both genders. Levels of first-time testing (68% vs. 29%, p < 0.0001) and re-testing (94% vs. 74%, p < 0.0001) were higher in the intervention than in the control arm. Acceptance of HIV testing and counselling is dependent on stigma, trust and gender. The confidentiality of home-based VCT was essential for overcoming stigma-related barriers, and the selection of local counsellors was important to ensure trust in the services. The high level of couple counselling within HB-VCT may contribute to closing the gender gap in HIV testing, and has benefits for both genders and potentially for prevention of HIV transmission. The study demonstrates the feasibility of achieving high test coverage with an opt-in consent approach. The embedded qualitative component confirmed the high satisfaction with HB-VCT reported in the quantitative survey and was

  14. The seven Cs of the high acceptability of home-based VCT: results from a mixed methods approach in Zambia.

    PubMed

    Jürgensen, Marte; Sandøy, Ingvild F; Michelo, Charles; Fylkesnes, Knut; Mwangala, Sheila; Blystad, Astrid

    2013-11-01

    HIV testing and counselling is a critical gateway to prevention and treatment. Yet, coverage remains insufficient, few couples are tested together and gender differences in access exist. We used an embedded mixed methods approach to investigate possible explanations for the high acceptance of home-based voluntary HIV counselling and testing (HB-VCT) in a pair-matched cluster-randomized trial in Zambia. A baseline survey included 1694 individuals in 36 clusters. Adults in 18 intervention clusters were offered HB-VCT by lay counsellors. Standard testing services were available in both trial arms. After the completion of the intervention, a follow-up survey was conducted in all trial clusters. In addition, 21 in-depth interviews and one focus group discussion were conducted with home-based VCT clients in the intervention arm. Informants favoured the convenience, confidentiality and credibility of HB-VCT. Counsellors were perceived as trustworthy owing to their closeness and conduct, and the consent process was experienced as convincing. Couple testing was selected by 70% of cohabiting couples and was experienced as beneficial by both genders. Levels of first-time testing (68% vs. 29%, p < 0.0001) and re-testing (94% vs. 74%, p < 0.0001) were higher in the intervention than in the control arm. Acceptance of HIV testing and counselling is dependent on stigma, trust and gender. The confidentiality of home-based VCT was essential for overcoming stigma-related barriers, and the selection of local counsellors was important to ensure trust in the services. The high level of couple counselling within HB-VCT may contribute to closing the gender gap in HIV testing, and has benefits for both genders and potentially for prevention of HIV transmission. The study demonstrates the feasibility of achieving high test coverage with an opt-in consent approach. The embedded qualitative component confirmed the high satisfaction with HB-VCT reported in the quantitative survey and was

  15. Standardization of the method for utilization of paneer whey in cultured buttermilk.

    PubMed

    Ghanshyambhai, Maheta Riddhiben; Balakrishnan, Smitha; Aparnathi, K D

    2015-05-01

    Whey is a liquid by-product obtained during manufacture of coagulated milk products like paneer, cheese etc. Its disposal as waste leads to heavy load in dairy effluent and loss of valuable milk solids. For efficient and economic utilization of whey, a method was standardized for the preparation of cultured butter milk using paneer whey as one of the ingredient. It involved fermentation of paneer whey and double toned milk separately using starter culture containing Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. The paneeer whey can be successfully incorporated up to 50 % by following the standardized method. The proximate chemical composition of cultured buttermilk was 8.31 % total solids, 2.26 % protein, 1.12 % fat, 4.42 % lactose and 0.56 % ash. The cultured buttermilk has acceptable sensory qualities and shelf life of 5 days under refrigerated condition.

  16. Standard test method for vinyl chloride in workplace atmospheres (charcoal tube method). ASTM standard

    SciTech Connect

    1998-07-01

    This test method is under the jurisdiction of ASTM Committee D-22 on Sampling and Analysis of Atmospheres and is the direct responsibility of Subcommittee D22.04 on Workplace Atmospheres. Current edition approved May 10, 1998. Published July 1998. Originally published as D 4766-88. Last previous edition D 4766-88(1993). Copyright American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West Conshohocken, PA, 19428, USA. This document is available from NTIS under license from ASTM.

  17. A method to investigate drivers' acceptance of Blind Spot Detection System®.

    PubMed

    Piccinini, Giuliofrancesco; Simões, Anabela; Rodrigues, Carlos Manuel; Leitão, Miguel

    2012-01-01

    Lately, with the goal of improving road safety, car makers developed and commercialised some Advanced Driver Assistance Systems (ADAS) which, through the detection of blind spot areas on the vehicle's sides, could help the drivers during the overtaking and the change lane task. Despite the possible benefits to reduce lateral crashes, the overall impact on road safety of such systems have not been deeply studied yet; notably, despite some researches have been carried out, there is a lack of studies regarding the long-term usage and drivers' acceptance of those systems. In order to fill the research gap, a methodology, based on the combination of focus groups interviews, questionnaires and a small-scale field operational test (FOT), has been designed in this study; such a methodology aims at evaluating drivers' acceptance of Blind Spot Information System® and at proposing some ideas to improve the usability and user-friendliness of this (or similar) device in their future development.

  18. Visualization of seismic tomography on Google Earth: Improvement of KML generator and its web application to accept the data file in European standard format

    NASA Astrophysics Data System (ADS)

    Yamagishi, Y.; Yanaka, H.; Tsuboi, S.

    2009-12-01

    We have developed a conversion tool for the data of seismic tomography into KML, called KML generator, and made it available on the web site (http://www.jamstec.go.jp/pacific21/google_earth). The KML generator enables us to display vertical and horizontal cross sections of the model on Google Earth in three-dimensional manner, which would be useful to understand the Earth's interior. The previous generator accepts text files of grid-point data having longitude, latitude, and seismic velocity anomaly. Each data file contains the data for each depth. Metadata, such as bibliographic reference, grid-point interval, depth, are described in other information file. We did not allow users to upload their own tomographic model to the web application, because there is not standard format to represent tomographic model. Recently European seismology research project, NEIRES (Network of Research Infrastructures for European Seismology), advocates that the data of seismic tomography should be standardized. They propose a new format based on JSON (JavaScript Object Notation), which is one of the data-interchange formats, as a standard one for the tomography. This format consists of two parts, which are metadata and grid-point data values. The JSON format seems to be powerful to handle and to analyze the tomographic model, because the structure of the format is fully defined by JavaScript objects, thus the elements are directly accessible by a script. In addition, there exist JSON libraries for several programming languages. The International Federation of Digital Seismograph Network (FDSN) adapted this format as a FDSN standard format for seismic tomographic model. There might be a possibility that this format would not only be accepted by European seismologists but also be accepted as the world standard. Therefore we improve our KML generator for seismic tomography to accept the data file having also JSON format. We also improve the web application of the generator so that the

  19. Rape Myth Acceptance among Korean College Students: The Roles of Gender, Attitudes toward Women, and Sexual Double Standard

    ERIC Educational Resources Information Center

    Lee, Joohee; Kim, Jinseok; Lim, Hyunsung

    2010-01-01

    The purpose of the current study was to examine factors that influence rape myths among Korean college students. This study was particularly interested in the ways in which attitudes toward women and sexual double standard affect the relationship between gender and rape myths. Although the incidence of rape is a common concern in many current…

  20. Psychosocial determinants of physicians' acceptance of recommendations by antibiotic computerised decision support systems: A mixed methods study.

    PubMed

    Chow, Angela; Lye, David C B; Arah, Onyebuchi A

    2015-03-01

    Antibiotic computerised decision support systems (CDSSs) were developed to facilitate optimal prescribing, but acceptance of their recommendations has remained low. We aimed to evaluate physicians' perceptions and attitudes toward antibiotic CDSSs and determine psychosocial factors associated with acceptance of CDSS recommendations for empirical therapy. A mixed methods study was conducted in an adult tertiary-care hospital in Singapore, with its in-house antibiotic CDSS that integrates antimicrobial stewardship with electronic prescribing. Focus group discussions were conducted among purposively sampled physicians and data were analysed using the framework approach. Emerging themes were included in the questionnaire with newly developed scales for the subsequent cross-sectional survey involving all physicians. Principal components analysis was performed to derive the latent factor structure that was later applied in multivariate analyses. Physicians expressed confidence in the credibility of CDSS recommendations. Junior physicians accepted CDSS recommendations most of the time, whilst senior physicians acknowledged overriding recommendations in complex patients with multiple infections or allergies. Willingness to consult the CDSS for common and complex infections (OR=1.68, 95% CI 1.16-2.44) and preference for personal or team decision (OR=0.61, 95% CI 0.43-0.85) were associated with acceptance of CDSS recommendations. Cronbach's α for scales measuring physicians' attitudes and perceptions towards acceptance of CDSS recommendations ranged from 0.64 to 0.88. Physicians' willingness to consult an antibiotic CDSS determined acceptance of its recommendations. Physicians would choose to exercise their own or clinical team's decision over CDSS recommendations in complex patient situations when the antibiotic prescribing needs were not met.

  1. Inventory of Safety-related Codes and Standards for Energy Storage Systems with some Experiences related to Approval and Acceptance

    SciTech Connect

    Conover, David R.

    2014-09-11

    The purpose of this document is to identify laws, rules, model codes, codes, standards, regulations, specifications (CSR) related to safety that could apply to stationary energy storage systems (ESS) and experiences to date securing approval of ESS in relation to CSR. This information is intended to assist in securing approval of ESS under current CSR and to identification of new CRS or revisions to existing CRS and necessary supporting research and documentation that can foster the deployment of safe ESS.

  2. Local tolerance testing under REACH: Accepted non-animal methods are not on equal footing with animal tests.

    PubMed

    Sauer, Ursula G; Hill, Erin H; Curren, Rodger D; Raabe, Hans A; Kolle, Susanne N; Teubner, Wera; Mehling, Annette; Landsiedel, Robert

    2016-07-01

    In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been combined into testing strategies for skin and eye irritation and skin sensitisation testing, with pre-defined prediction models for substance classification. Many of these methods have been adopted as OECD test guidelines. Various testing strategies have been successfully validated in extensive in-house and inter-laboratory studies, but they have not yet received formal acceptance for substance classification. Therefore, under the European REACH Regulation, data from testing strategies can, in general, only be used in so-called weight-of-evidence approaches. While animal testing data generated under the specific REACH information requirements are per se sufficient, the sufficiency of weight-of-evidence approaches can be questioned under the REACH system, and further animal testing can be required. This constitutes an imbalance between the regulatory acceptance of data from approved non-animal methods and animal tests that is not justified on scientific grounds. To ensure that testing strategies for local tolerance testing truly serve to replace animal testing for the REACH registration 2018 deadline (when the majority of existing chemicals have to be registered), clarity on their regulatory acceptance as complete replacements is urgently required.

  3. Local tolerance testing under REACH: Accepted non-animal methods are not on equal footing with animal tests.

    PubMed

    Sauer, Ursula G; Hill, Erin H; Curren, Rodger D; Raabe, Hans A; Kolle, Susanne N; Teubner, Wera; Mehling, Annette; Landsiedel, Robert

    2016-07-01

    In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been combined into testing strategies for skin and eye irritation and skin sensitisation testing, with pre-defined prediction models for substance classification. Many of these methods have been adopted as OECD test guidelines. Various testing strategies have been successfully validated in extensive in-house and inter-laboratory studies, but they have not yet received formal acceptance for substance classification. Therefore, under the European REACH Regulation, data from testing strategies can, in general, only be used in so-called weight-of-evidence approaches. While animal testing data generated under the specific REACH information requirements are per se sufficient, the sufficiency of weight-of-evidence approaches can be questioned under the REACH system, and further animal testing can be required. This constitutes an imbalance between the regulatory acceptance of data from approved non-animal methods and animal tests that is not justified on scientific grounds. To ensure that testing strategies for local tolerance testing truly serve to replace animal testing for the REACH registration 2018 deadline (when the majority of existing chemicals have to be registered), clarity on their regulatory acceptance as complete replacements is urgently required. PMID:27494627

  4. Bootstrap-based methods for estimating standard errors in Cox's regression analyses of clustered event times.

    PubMed

    Xiao, Yongling; Abrahamowicz, Michal

    2010-03-30

    We propose two bootstrap-based methods to correct the standard errors (SEs) from Cox's model for within-cluster correlation of right-censored event times. The cluster-bootstrap method resamples, with replacement, only the clusters, whereas the two-step bootstrap method resamples (i) the clusters, and (ii) individuals within each selected cluster, with replacement. In simulations, we evaluate both methods and compare them with the existing robust variance estimator and the shared gamma frailty model, which are available in statistical software packages. We simulate clustered event time data, with latent cluster-level random effects, which are ignored in the conventional Cox's model. For cluster-level covariates, both proposed bootstrap methods yield accurate SEs, and type I error rates, and acceptable coverage rates, regardless of the true random effects distribution, and avoid serious variance under-estimation by conventional Cox-based standard errors. However, the two-step bootstrap method over-estimates the variance for individual-level covariates. We also apply the proposed bootstrap methods to obtain confidence bands around flexible estimates of time-dependent effects in a real-life analysis of cluster event times.

  5. Current and future Internet transmission methods: technical challenges and practical solutions for widespread acceptance of ADSL

    NASA Astrophysics Data System (ADS)

    Polley, Michael O.

    1999-11-01

    The high data rates required to properly support emerging multimedia internet applications far exceed the capabilities of voiceband modems. For example, seamless real-time delivery of digital video clips might require connections up to 100 times faster. Asymmetric digital subscriber line (ADSL) modems provide residential internet users with a much-needed solution to this remote access bandwidth shortage. ADSL modems connected directly to the internet are installed in the telephone company central office, allowing remote access over the copper twisted pair telephone line by remote transceivers in the homes of residential customers. Because the internet data does not have to pass through the telephone switching network, the ADSL link can provide data rates in the Mbit/sec range. However, for ADSL modems to gain broad acceptance an displace their low rate voiceband counterparts, low cost, ease of installation, and high quality of service must be achieved.

  6. Bricks and blueprints: methods and standards for DNA assembly.

    PubMed

    Casini, Arturo; Storch, Marko; Baldwin, Geoffrey S; Ellis, Tom

    2015-09-01

    DNA assembly is a key part of constructing gene expression systems and even whole chromosomes. In the past decade, a plethora of powerful new DNA assembly methods - including Gibson Assembly, Golden Gate and ligase cycling reaction (LCR) - have been developed. In this Innovation article, we discuss these methods as well as standards such as the modular cloning (MoClo) system, GoldenBraid, modular overlap-directed assembly with linkers (MODAL) and PaperClip, which have been developed to facilitate a streamlined assembly workflow, to aid the exchange of material between research groups and to create modular reusable DNA parts.

  7. A Triangle Mesh Standardization Method Based on Particle Swarm Optimization.

    PubMed

    Wang, Wuli; Duan, Liming; Bai, Yang; Wang, Haoyu; Shao, Hui; Zhong, Siyang

    2016-01-01

    To enhance the triangle quality of a reconstructed triangle mesh, a novel triangle mesh standardization method based on particle swarm optimization (PSO) is proposed. First, each vertex of the mesh and its first order vertices are fitted to a cubic curve surface by using least square method. Additionally, based on the condition that the local fitted surface is the searching region of PSO and the best average quality of the local triangles is the goal, the vertex position of the mesh is regulated. Finally, the threshold of the normal angle between the original vertex and regulated vertex is used to determine whether the vertex needs to be adjusted to preserve the detailed features of the mesh. Compared with existing methods, experimental results show that the proposed method can effectively improve the triangle quality of the mesh while preserving the geometric features and details of the original mesh. PMID:27509129

  8. A Triangle Mesh Standardization Method Based on Particle Swarm Optimization

    PubMed Central

    Duan, Liming; Bai, Yang; Wang, Haoyu; Shao, Hui; Zhong, Siyang

    2016-01-01

    To enhance the triangle quality of a reconstructed triangle mesh, a novel triangle mesh standardization method based on particle swarm optimization (PSO) is proposed. First, each vertex of the mesh and its first order vertices are fitted to a cubic curve surface by using least square method. Additionally, based on the condition that the local fitted surface is the searching region of PSO and the best average quality of the local triangles is the goal, the vertex position of the mesh is regulated. Finally, the threshold of the normal angle between the original vertex and regulated vertex is used to determine whether the vertex needs to be adjusted to preserve the detailed features of the mesh. Compared with existing methods, experimental results show that the proposed method can effectively improve the triangle quality of the mesh while preserving the geometric features and details of the original mesh. PMID:27509129

  9. Acceptability of human risk.

    PubMed Central

    Kasperson, R E

    1983-01-01

    This paper has three objectives: to explore the nature of the problem implicit in the term "risk acceptability," to examine the possible contributions of scientific information to risk standard-setting, and to argue that societal response is best guided by considerations of process rather than formal methods of analysis. Most technological risks are not accepted but are imposed. There is also little reason to expect consensus among individuals on their tolerance of risk. Moreover, debates about risk levels are often at base debates over the adequacy of the institutions which manage the risks. Scientific information can contribute three broad types of analyses to risk-setting deliberations: contextual analysis, equity assessment, and public preference analysis. More effective risk-setting decisions will involve attention to the process used, particularly in regard to the requirements of procedural justice and democratic responsibility. PMID:6418541

  10. Toward a universal standard: comparing two methods for standardizing spotted microarray data.

    PubMed

    Weil, Michael Ryan; Macatee, Timothy; Garner, Harold R

    2002-06-01

    DNA microarray technology has allowed the transcriptome to be studied to a depth that was inconceivable only 10 years ago. Until recently these studies were isolated because, without a universal standard, the results from experiment to experiment and laboratory to laboratory were not directly comparable. For human microarrays, this problem has been addressed by numerous methods, but only two are truly universal. The first method uses genomic DNA as a standard for comparison since it is, by definition, complete and universally available. The second method employs a highly representative total RNA pool such as the one currently available from Stratagene. To determine the advantages and disadvantages of both methods, they were directly compared by hybridization to the University of Texas Southwestern Medical Center's 4000- or 10800-member human cDNA array, using typical microarray techniques. The labeled analytes were 2 microg normal human genomic DNA labeled by nick translation or 20 microg total RNA pool labeled by reverse transcription. The resulting data were then background-subtracted, analyzed, and the number of spots above a background threshold was compared in each sample. Using the McNemar test and a Yate's correction with one degree of freedom, the samples were statistically identical with chi2 = 3.72.

  11. 19 CFR 134.44 - Location and other acceptable methods of marking.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Method and Location of Marking Imported... Customs, any method of marking at any location insuring that country of origin will conspicuously...

  12. Preferred delivery method and acceptability of Wheat-Soy Blend (WSB++) as a daily complementary food supplement in northwest Bangladesh.

    PubMed

    Shamim, Abu Ahmed; Hanif, Abu A M; Merrill, Rebecca D; Campbell, Rebecca K; Kumkum, Mehnaz Alam; Shaikh, Saijuddin; de Pee, Saskia; Ahmed, Tahmeed; Parveen, Monira; Mehra, Sucheta; Klemm, Rolf D W; Labrique, Alain B; West, Keith P; Christian, Parul

    2015-01-01

    Fortified blended foods (FBFs) are widely used to prevent undernutrition in early childhood in food-insecure settings. We field tested enhanced Wheat Soy Blend (WSB++)-a FBF fortified with micronutrients, milk powder, sugar, and oil-in preparation for a complementary food supplement (CFS) trial in rural northwestern Bangladesh. Formative work was conducted to determine the optimal delivery method (cooked vs. not) for this CFS, to examine mothers' child feeding practices with and acceptance of the WSB++, and to identify potential barriers to adherence. Our results suggest WSB++ is an acceptable CFS in rural Bangladesh and the requirement for mothers to cook WSB++ at home is unlikely to be a barrier to its daily use as a CFS in this population. PMID:25427283

  13. Characterization of IPMC actuators using standard testing methods

    NASA Astrophysics Data System (ADS)

    Fernández, D.; Espinosa, R.; Moreno, L.; Baselga, J.

    2006-03-01

    In response to a clear need, the research community on EAP (Electroactive Polymer) has just started to work on a standard test methodology to characterize EAP actuators. A very general test methodology for EAPs, covering the characterization procedures for extensional and bending actuators was recently presented. In the present work, well known IPMC samples are characterized following such test methodology. Also, additional tests, not covered by the preliminary standard are included. These tests are conducted using the EAP Unit Tester, a test bench specifically designed for the characterization of EAP actuators. Rather than presenting new material's results, the paper focuses on the instrumentation, procedures and form of presenting results. Although the paper is focused on IPMC the method can be extrapolated to other bending actuators.

  14. [Standardization of the method of osmolality determination of specialized foods].

    PubMed

    Vorobyeva, I S; Kochetkova, A A; Vorobyeva, V M

    2015-01-01

    Binding requirements for the application and enforcement at the customs territory for specialized food products have been installed in the established documents of the Customs Union. The category of specialized foods consists of food products for babies, for pregnant and lactating women, dietary products (clinical and preventive nutrition), sport nutrition. In addition to the General safety requirements that must be met by specialized food products, the value of osmolality must be regulated in some kinds of such products. The specialists of Institute of Nutrition developed national standard "Specialized foods. Method of osmolality determination" for the purpose of standardization of a method of osmolality determining. Product samples for baby and sport nutrition which are realized on domestic market have been researched. Specialized products for baby food had osmolality from 290 to 327 mOsm/kg, that corresponded to the requirements of regulatory documents applicable to this product group. Osmolality of carbohydrate and mineral drink for athletes was in the range from 308 to 330 mOsm/kg, confirming their belonging to the isotonic drinks. The method can be used in researches for developing of the new products with specific predetermined chemical composition and in clinical practice for the osmolality control of products for enternal nutrition. PMID:26841559

  15. Goat milk acceptance and promotion methods in Japan: The questionnaire survey to middle class households.

    PubMed

    Ozawa, Takeyuki; Mukuda, Kumiko; Fujita, Masaru; Nishitani, Jiro

    2009-04-01

    A consumer questionnaire conducted with the purpose of ascertaining the acceptability of goat milk and related products in Japan was carried out on 345 guarantees of Nippon Veterinary and Life Science University in December 2006. 275 effective responses (79%) representing middle class urban households were returned. The results revealed that (1) 30% of respondents have experienced drinking goat milk and only 10% are aware of the current retail situation of goat milk and related products; (2) over 70% of goat milk drinkers raised goats by hand at some point in their past and their first experience drinking goat milk was in infancy; (3) those with experience in drinking goat milk expressed a vague evaluation and minimal understanding of drinking goat milk; (4) respondents who were inexperienced goat milk drinkers expressed a strong desire to taste and a weak desire to purchase goat milk; (5) respondents expressed low recognition regarding retailed goat milk products, but those who had already purchased goat milk products expressed a high evaluation and strong desire to purchase these products again; and (6) recognition of goat milk characteristics is low, but those with high recognition also rate goat milk highly. Goats are perceived as being 'mild and familiar.' It is necessary for those who manage goat husbandry to present goat milk and related product tasting opportunities to consumers. The key point is to make the functional differences between cow and goat milk clear and present the advantages of goat milk at the fore of this promotion. Goat milk should not be promoted merely as a drink that is similar to cow milk, but must be positioned as a functional drink or health food in order to expand the Japanese goat milk market.

  16. Goat milk acceptance and promotion methods in Japan: The questionnaire survey to middle class households.

    PubMed

    Ozawa, Takeyuki; Mukuda, Kumiko; Fujita, Masaru; Nishitani, Jiro

    2009-04-01

    A consumer questionnaire conducted with the purpose of ascertaining the acceptability of goat milk and related products in Japan was carried out on 345 guarantees of Nippon Veterinary and Life Science University in December 2006. 275 effective responses (79%) representing middle class urban households were returned. The results revealed that (1) 30% of respondents have experienced drinking goat milk and only 10% are aware of the current retail situation of goat milk and related products; (2) over 70% of goat milk drinkers raised goats by hand at some point in their past and their first experience drinking goat milk was in infancy; (3) those with experience in drinking goat milk expressed a vague evaluation and minimal understanding of drinking goat milk; (4) respondents who were inexperienced goat milk drinkers expressed a strong desire to taste and a weak desire to purchase goat milk; (5) respondents expressed low recognition regarding retailed goat milk products, but those who had already purchased goat milk products expressed a high evaluation and strong desire to purchase these products again; and (6) recognition of goat milk characteristics is low, but those with high recognition also rate goat milk highly. Goats are perceived as being 'mild and familiar.' It is necessary for those who manage goat husbandry to present goat milk and related product tasting opportunities to consumers. The key point is to make the functional differences between cow and goat milk clear and present the advantages of goat milk at the fore of this promotion. Goat milk should not be promoted merely as a drink that is similar to cow milk, but must be positioned as a functional drink or health food in order to expand the Japanese goat milk market. PMID:20163593

  17. A Think Aloud Study Comparing the Validity and Acceptability of Discrete Choice and Best Worst Scaling Methods

    PubMed Central

    Whitty, Jennifer A.; Walker, Ruth; Golenko, Xanthe; Ratcliffe, Julie

    2014-01-01

    Objectives This study provides insights into the validity and acceptability of Discrete Choice Experiment (DCE) and profile-case Best Worst Scaling (BWS) methods for eliciting preferences for health care in a priority-setting context. Methods An adult sample (N = 24) undertook a traditional DCE and a BWS choice task as part of a wider survey on Health Technology Assessment decision criteria. A ‘think aloud’ protocol was applied, whereby participants verbalized their thinking while making choices. Internal validity and acceptability were assessed through a thematic analysis of the decision-making process emerging from the qualitative data and a repeated choice task. Results A thematic analysis of the decision-making process demonstrated clear evidence of ‘trading’ between multiple attribute/levels for the DCE, and to a lesser extent for the BWS task. Limited evidence consistent with a sequential decision-making model was observed for the BWS task. For the BWS task, some participants found choosing the worst attribute/level conceptually challenging. A desire to provide a complete ranking from best to worst was observed. The majority (18,75%) of participants indicated a preference for DCE, as they felt this enabled comparison of alternative full profiles. Those preferring BWS were averse to choosing an undesirable characteristic that was part of a ‘package’, or perceived BWS to be less ethically conflicting or burdensome. In a repeated choice task, more participants were consistent for the DCE (22,92%) than BWS (10,42%) (p = 0.002). Conclusions This study supports the validity and acceptability of the traditional DCE format. Findings relating to the application of BWS profile methods are less definitive. Research avenues to further clarify the comparative merits of these preference elicitation methods are identified. PMID:24759637

  18. Standard Methods for Bolt-Bearing Testing of Textile Composites

    NASA Technical Reports Server (NTRS)

    Portanova, M. A.; Masters, J. E.

    1995-01-01

    The response of three 2-D braided materials to bolt bearing loading was evaluated using data generated by Boeing Defense and Space Group in Philadelphia, PA. Three test methods, stabilized single shear, unstabilized single shear, and double shear, were compared. In general, these textile composites were found to be sensitive to bolt bearing test methods. The stabilized single shear method yielded higher strengths than the unstabilized single shear method in all cases. The double shear test method always produced the highest strengths but these results may be somewhat misleading. It is therefore recommended that standard material comparisons be made using the stabilized single shear test method. The effects of two geometric parameters, W/D and e/D, were also studied. An evaluation of the effect of the specimen width (W) to hole diameter (D) ratio concluded that bolt bearing responses were consistent with open hole tension results. A W/D ratio of 6 or greater should be maintained. The proximity of the hole to the specimen edge significantly affected strength. In all cases, strength was improved by increasing the ratio of the distance from the hole center to the specimen edge (e) to the hole diameter (D) above 2. An e/D ratio of 3 or greater is recommended.

  19. The importance of male partner involvement for women's acceptability and adherence to female-initiated HIV prevention methods in Zimbabwe.

    PubMed

    Montgomery, Elizabeth T; van der Straten, Ariane; Chidanyika, Agnes; Chipato, Tsungai; Jaffar, Shabbar; Padian, Nancy

    2011-07-01

    Enlisting male partner involvement is perceived as an important component of women's successful uptake of female-initiated HIV prevention methods. We conducted a longitudinal study among a cohort of 955 Zimbabwean women participating in a clinical trial of the effectiveness of a female-initiated HIV prevention method (the diaphragm and lubricant gel) to: (a) describe the extent to which women involved their male partners in the decision to use the study products, and (b) measure the effect perceived male partner support had on their acceptability and consistent use of these methods. Reported levels of male partner involvement in discussions and decisions regarding: joining the study, study activities, the outcome of HIV/STI test results, and product use were very high. In multivariate analyses, regular disclosure of study product use and partner approval for the diaphragm and gel were significantly associated with women's acceptability and consistent use of the products; an essential component for determining efficacy of investigational prevention methods. These results support the need for more sophisticated measurement of how couples interact to make decisions that impact study participation and investigational product use as well as more rigorous adaptations and evaluations of existing strategies to involve male partners in female-initiated HIV prevention trials.

  20. The importance of male partner involvement for women's acceptability and adherence to female-initiated HIV prevention methods in Zimbabwe.

    PubMed

    Montgomery, Elizabeth T; van der Straten, Ariane; Chidanyika, Agnes; Chipato, Tsungai; Jaffar, Shabbar; Padian, Nancy

    2011-07-01

    Enlisting male partner involvement is perceived as an important component of women's successful uptake of female-initiated HIV prevention methods. We conducted a longitudinal study among a cohort of 955 Zimbabwean women participating in a clinical trial of the effectiveness of a female-initiated HIV prevention method (the diaphragm and lubricant gel) to: (a) describe the extent to which women involved their male partners in the decision to use the study products, and (b) measure the effect perceived male partner support had on their acceptability and consistent use of these methods. Reported levels of male partner involvement in discussions and decisions regarding: joining the study, study activities, the outcome of HIV/STI test results, and product use were very high. In multivariate analyses, regular disclosure of study product use and partner approval for the diaphragm and gel were significantly associated with women's acceptability and consistent use of the products; an essential component for determining efficacy of investigational prevention methods. These results support the need for more sophisticated measurement of how couples interact to make decisions that impact study participation and investigational product use as well as more rigorous adaptations and evaluations of existing strategies to involve male partners in female-initiated HIV prevention trials. PMID:20844946

  1. Harmonization of standard toxicity test methods used in North America

    SciTech Connect

    Ingersoll, C.G.; Dwyer, F.J.; Ankley, G.T.

    1995-12-31

    Over the past two years, Environment Canada (EC) and the US Environmental Protection Agency (EPA) have developed standard methods for conducting toxicity and bioaccumulation tests with freshwater, estuarine, and marine sediments. Existing ASTM methods were used as a basis to harmonize these methods for conducting testing with either field-collected or laboratory-spiked sediments. For freshwater toxicity tests, methods are described by EC and EPA for the amphipod Hyalella azteca and the midges Chironomus tentans and C. riparius. Endpoints include 10- to 14-d survival of growth. Methods are also described by EPA for conducting 28-d bioaccumulation tests with the oligochaete Lumbriculus variegatus. For estuarine and marine toxicity tests, methods are described for several amphipods (i.e., Rhepoxynius abronius, Ampelisca abdita, Eohaustorius estuarius, Leptocheirus plumulosus). Endpoints include 10-d survival and reburial. EC is also developing methods for conducting toxicity tests with Atlantic, Pacific, and Arctic Canadian species of polychaetes. Methods are described by EPA for conducting 28-d bioaccumulation tests with a variety of mollusks (i.e., Macoma spp.) and polychaetes (i.e., Nereis spp.). Slight inconsistencies in methods between freshwater and estuarine/marine testing or between EC and EPA testing include: (1) static vs. flow-through conditions, (2) sieving of sediment, (3) types and quantity of food, (4) age of test organisms, or (4) duration of the test and required endpoints. Additional research is in progress to: (1) develop chronic toxicity tests with amphipods and midges measuring survival, growth, or reproduction, (2) develop whole-sediment toxicity identification evaluation (TIE) procedures, (3) refine sediment spiking procedures, and (4) field-validate laboratory tests.

  2. Standard test method for saponification number of petroleum products

    SciTech Connect

    Not Available

    1980-01-01

    This method covers the determination of the amount of constituents in petroleum products that will saponify under the conditions of the test. Since compounds of sulfur, phosphorus, the halogens, and certain other elements which are sometimes added to petroleum products also consume alkali and acids, the results obtained indicate the effect of these extraneous materials in addition to the saponifiable material present. Results on products containing such materials, on used internal-combustion-engine crank-case oils, and on used turbine oils must be interpreted in this respect. Summary of method: a known weight of the sample, dissolved in methylethylketone is heated with a known amount of alcoholic potassium hydroxide (KOH). The excess alkali is titrated with standard acid and the saponification number calculated.

  3. [Standardization of technical methods for apple fluorescence canopy spectral detection].

    PubMed

    Zhu, Xi-Cun; Zhao, Geng-Xing; Lei, Tong; Wang, Ling; Dong, Fang; Wang, Jing-An

    2010-06-01

    Aiming at spectral detection of apple fluorescence canopy, the present paper carried out spectral detection tests under different weather conditions, different detection times, and different detection heights and angles to apple canopy in the two years of 2008 and 2009, so as to analyze impacts of these factors on apple canopy spectral characteristics and explore standardized spectral detection methods for apple fluorescence canopy. The results indicated the regularity in spectral reflectance of apple fluorescence canopy to a certain degree under different conditions, especially in the 760-1 350 nm near-infrared bands. The authors found that canopy spectral reflectance declined along with the decrease in sunshine and it is appropriate to detect canopy spectrum in sunny days with few clouds. In addition, spectral reflectance tended to be stable when the wind scale was below grade 2. The discrepancy of canopy spectra is small during the time period from 10:00 to 15:00 of a day compared to that of other times. For maintaining stable spectral curves, the height of detector to apple canopy needed to be adjusted to cover the whole canopy within the field of view according to detection angle of the detector. The vertical or approximately vertical detection was the best for canopy spectral reflectance acquisition. The standardization of technical methods of spectral detection for apple fluorescence canopy was proposed accordingly, which provided theoretical references for spectral detection and information extraction of apple tree canopy.

  4. A statistical model for assessing performance standards for quantitative and semiquantitative disinfectant test methods.

    PubMed

    Parker, Albert E; Hamilton, Martin A; Tomasino, Stephen F

    2014-01-01

    A performance standard for a disinfectant test method can be evaluated by quantifying the (Type I) pass-error rate for ineffective products and the (Type II) fail-error rate for highly effective products. This paper shows how to calculate these error rates for test methods where the log reduction in a microbial population is used as a measure of antimicrobial efficacy. The calculations can be used to assess performance standards that may require multiple tests of multiple microbes at multiple laboratories. Notably, the error rates account for among-laboratory variance of the log reductions estimated from a multilaboratory data set and the correlation among tests of different microbes conducted in the same laboratory. Performance standards that require that a disinfectant product pass all tests or multiple tests on average, are considered. The proposed statistical methodology is flexible and allows for a different acceptable outcome for each microbe tested, since, for example, variability may be different for different microbes. The approach can also be applied to semiquantitative methods for which product efficacy is reported as the number of positive carriers out of a treated set and the density of the microbes on control carriers is quantified, thereby allowing a log reduction to be calculated. Therefore, using the approach described in this paper, the error rates can also be calculated for semiquantitative method performance standards specified solely in terms of the maximum allowable number of positive carriers per test. The calculations are demonstrated in a case study of the current performance standard for the semiquantitative AOAC Use-Dilution Methods for Pseudomonas aeruginosa (964.02) and Staphylococcus aureus (955.15), which allow up to one positive carrier out of a set of 60 inoculated and treated carriers in each test. A simulation study was also conducted to verify the validity of the model's assumptions and accuracy. Our approach, easily implemented

  5. Standard methods for open hole tension testing of textile composites

    NASA Technical Reports Server (NTRS)

    Portanova, M. A.; Masters, J. E.

    1995-01-01

    Sizing effects have been investigated by comparing the open hole failure strengths of each of the four different braided architectures as a function of specimen thickness, hole diameter, and the ratio of specimen width to hole diameter. The data used to make these comparisons was primarily generated by Boeing. Direct comparisons of Boeing's results were made with experiments conducted at West Virginia University whenever possible. Indirect comparisons were made with test results for other 2-D braids and 3-D weaves tested by Boeing and Lockheed. In general, failure strength was found to decrease with increasing plate thickness, increase with decreasing hole size, and decreasing with decreasing width to diameter ratio. The interpretation of the sensitive to each of these geometrical parameters was complicated by scatter in the test data. For open hole tension testing of textile composites, the use of standard testing practices employed by industry, such as ASTM D5766 - Standard Test Method for Open Hole Tensile Strength of Polymer Matrix Composite Laminates should provide adequate results for material comparisons studies.

  6. Extension of the standard addition method by blank addition.

    PubMed

    Steliopoulos, Panagiotis

    2015-01-01

    Standard addition involves adding varying amounts of the analyte to sample portions of fixed mass or fixed volume and submitting those portions to the sample preparation procedure. After measuring the final extract solutions, the observed signals are linearly regressed on the spiked amounts. The original unknown amount is estimated by the opposite of the abscissa intercept of the fitted straight line [1]. A limitation of this method is that only data points with abscissa values equal to and greater than zero are available so that there is no information on whether linearity holds below the spiking level zero. An approach to overcome this limitation is introduced.•Standard addition is combined with blank addition.•Blank addition means that defined mixtures of blank matrix and sample material are subjected to sample preparation to give final extract solutions.•Equations are presented to estimate the original unknown amount and to calculate the 1-2α confidence interval about this estimate using the combined data set.

  7. Standardization of methods for extracting statistics from surface profile measurements

    NASA Astrophysics Data System (ADS)

    Takacs, Peter Z.

    2014-08-01

    Surface profilers and optical interferometers produce 2D maps of surface and wavefront topography. Traditional standards and methods for characterizing the properties of these surfaces use coordinate space representations of the surface topography. The computing power available today in modest personal computers makes it easy to transform into frequency space and apply well-known signal processing techniques to analyze the data. The Power Spectral Density (PSD) function of the surface height distribution is a powerful tool to assess the quality and characteristics of the surface in question. In order to extract useful information about the spectral distribution of surface roughness or mid-spatial frequency error over a particular spatial frequency band, it is necessary to pre-process the data by first detrending the surface figure terms and then applying a window function before computing the PSD. This process eliminates discontinuities at the borders of the profile that would otherwise produce large amounts of spurious power that would mask the true nature of the surface texture. This procedure is now part of a new draft standard that is being adopted by the US OEOSC for analysis of the statistics of optical surface, OP1.005.1 Illustrations of the usefulness of these procedures will be presented.

  8. Extension of the standard addition method by blank addition

    PubMed Central

    Steliopoulos, Panagiotis

    2015-01-01

    Standard addition involves adding varying amounts of the analyte to sample portions of fixed mass or fixed volume and submitting those portions to the sample preparation procedure. After measuring the final extract solutions, the observed signals are linearly regressed on the spiked amounts. The original unknown amount is estimated by the opposite of the abscissa intercept of the fitted straight line [1]. A limitation of this method is that only data points with abscissa values equal to and greater than zero are available so that there is no information on whether linearity holds below the spiking level zero. An approach to overcome this limitation is introduced.•Standard addition is combined with blank addition.•Blank addition means that defined mixtures of blank matrix and sample material are subjected to sample preparation to give final extract solutions.•Equations are presented to estimate the original unknown amount and to calculate the 1-2α confidence interval about this estimate using the combined data set. PMID:26844210

  9. Remarks on Several Non-standard Location Methods

    NASA Astrophysics Data System (ADS)

    Jih, R.

    2004-05-01

    In this study, several non-standard location procedures are reviewed, contrasted, and compared. Though independently developed, two methods among those been tested, the "Induced Perpendicular Bisector" [IPB] (or,equivalently, the "Yin Zhong Zian" [YZX] in Chinese) method and Jih's (PEPI, 1999) "J0" method, appear to be extremely similar in concept. For several decades, i.e., since before the advent of digital computers, Asian seismic network operators have been locating earthquakes by triangulation using the IPB technique. In the ideal case where two seismographs happen to report identical arrival times of the same seismic phase, then under the assumption of a uniform earth structure, the hypocenter should lie on the perpendicular bisector of the line segment (great circle) which connects these two specific seismographs. Depending on the epicentral distances, the perpendicular bisector itself could be a great circle along the Earth's surface or a normal section cutting through the Earth. If two or more such perpendicular bisectors are available, then the hypocenter or epicenter can be determined via triangulation. The challenge lies in how the perpendicular bisector is derived for the more general situation when arrival times vary from station to station, which is more typically the case. An advantage of the technique is that it can be used when waveform data are not available, thus rendering techniques based on full waveforms (such as correlation analysis, polarization analysis and frequency-wavenumber [FK] technique) not applicable. The so-called YZX algorithm, is a variation of IPB procedure, in which one computes an IPB (via interpolation) for each group of three seismographs. Also relying on azimuth triangulation for seismic location, Jih (1999) proposed a procedure J0 to derive the backazimuth with a large aperture network where all seismographs are on one side of the event. Any standard Geiger-type of least-squares inversion routine can be applied to

  10. Can Subcision with the Cannula be an Acceptable Alternative Method in Treatment of Acne Scars?

    PubMed Central

    Nilforoushzadeh, Mohammadali; Lotfi, Elahe; Nickkholgh, Elmira; Salehi, Bahareh; Shokrani, Marjan

    2015-01-01

    Background and objectives: Most people who experience the acne suffer from damage under the surface of their skin which causes saucer-like depressions or pits on their skin. Sometimes the skin loses its underlying support and develops fibrous bands of tissue between the skin and subcutaneous layer, which pull on the epidermis and cause a wavy texture called as rolling scar. Treatment of acne scars is a therapeutic challenge that may require multiple modalities. Subcision is a procedure that has been reported as a beneficial method in the treatment of rolling acne scars. Although Subcision is a valuable method, its efficacy is mild to moderate because of the high recurrence rate and patients dissatisfaction due to some side effects include post procedure inflammation. Materials and methods: This pilot study is a clinical trial. The 8 patients suffered from mild to severe rolling acne scars on their face with symmetrical distribution of lesions, underwent Subcision with the Cannula No 18 and 21 and followed-up for 3 months. Outcomes of Subcision procedures were assessed by 3 board certified dermatologists (blind) after 2 session of treatment. The patients’ satisfaction was considered to compare with dermatologist’s opinions. The degree of improvement and satisfaction of the treatment estimated with these points: poor: 0, fine: 1-3, good: 4-6, and very good: 7-9. The data were finally analyzed with SPSS-18 software. Results: Subcision with the Cannula showed good and very good improvement in about 88% of patient with a satisfaction good and very good improvement in all of patients (100%). Assessment of photographic data showed 100% improvement in scar depth, topography and overall appearance of acne scars. The average numbers of lesions before the treatment were 24.8 ± 12.1 and after treatment it was reduced to 12.8 ± 2.1 (p<0.05). Conclusion: Subcision with the Cannula appears to be a safe method with high efficacy in the treatment and high satisfaction in

  11. Standardized methods for Grand Canyon fisheries research 2015

    USGS Publications Warehouse

    Persons, William R.; Ward, David L.; Avery, Luke A.

    2013-01-01

    This document presents protocols and guidelines to persons sampling fishes in the Grand Canyon, to help ensure consistency in fish handling, fish tagging, and data collection among different projects and organizations. Most such research and monitoring projects are conducted under the general umbrella of the Glen Canyon Dam Adaptive Management Program and include studies by the U.S. Geological Survey (USGS), U.S. Fish and Wildlife Service (FWS), National Park Service (NPS), the Arizona Game and Fish Department (AGFD), various universities, and private contractors. This document is intended to provide guidance to fieldworkers regarding protocols that may vary from year to year depending on specific projects and objectives. We also provide herein documentation of standard methods used in the Grand Canyon that can be cited in scientific publications, as well as a summary of changes in protocols since the document was first created in 2002.

  12. BSAC standardized disc susceptibility testing method (version 10).

    PubMed

    Andrews, J M; Howe, R A

    2011-12-01

    The BSAC standardized disc susceptibility testing method remains unchanged, but there are considerable changes to the interpretative criteria due to continuing harmonization with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) MIC breakpoints. There are a number of agents for which interpretative criteria have been removed. These MIC and/or zone diameter breakpoints will be published on the BSAC web site as a 'Legacy' table; they may be used for research or comparative purposes, but are not recommended for clinical management. Notably, testing of staphylococci for susceptibility to glycopeptides by disc diffusion has been removed because this method has been found to be unreliable, particularly for the detection of low-level resistance; low-level vancomycin resistance in staphylococci is increasingly deemed to be of clinical relevance. The tables for anaerobes have been expanded to include MIC breakpoints that have been determined by EUCAST. There are currently no zone diameter breakpoints for these organisms and an MIC method is recommended if susceptibility testing is required.

  13. A Comparison of School Psychologists' Acceptability, Training, and Use of Norm-Referenced, Curriculum-Based, and Brief Experimental Analysis Methods to Assess Reading

    ERIC Educational Resources Information Center

    Chafouleas, Sandra M.; Riley-Tillman, T. Chris; Eckert, Tanya L.

    2003-01-01

    This investigation compared the acceptability of three methods for assessing reading (i.e., norm-referenced assessment, curriculum-based assessment, brief experimental analysis), and explored how a new assessment methodology can gain acceptance as a useful and appropriate approach. Given that brief experimental analysis is a relatively new…

  14. Uniform-acceptance force-bias Monte Carlo method with time scale to study solid-state diffusion

    NASA Astrophysics Data System (ADS)

    Mees, Maarten J.; Pourtois, Geoffrey; Neyts, Erik C.; Thijsse, Barend J.; Stesmans, André

    2012-04-01

    Monte Carlo (MC) methods have a long-standing history as partners of molecular dynamics (MD) to simulate the evolution of materials at the atomic scale. Among these techniques, the uniform-acceptance force-bias Monte Carlo (UFMC) method [G. Dereli, Mol. Simul.10.1080/08927029208022490 8, 351 (1992)] has recently attracted attention [M. Timonova , Phys. Rev. BPRBMDO1098-012110.1103/PhysRevB.81.144107 81, 144107 (2010)] thanks to its apparent capacity of being able to simulate physical processes in a reduced number of iterations compared to classical MD methods. The origin of this efficiency remains, however, unclear. In this work we derive a UFMC method starting from basic thermodynamic principles, which leads to an intuitive and unambiguous formalism. The approach includes a statistically relevant time step per Monte Carlo iteration, showing a significant speed-up compared to MD simulations. This time-stamped force-bias Monte Carlo (tfMC) formalism is tested on both simple one-dimensional and three-dimensional systems. Both test-cases give excellent results in agreement with analytical solutions and literature reports. The inclusion of a time scale, the simplicity of the method, and the enhancement of the time step compared to classical MD methods make this method very appealing for studying the dynamics of many-particle systems.

  15. Bennett's acceptance ratio and histogram analysis methods enhanced by umbrella sampling along a reaction coordinate in configurational space

    NASA Astrophysics Data System (ADS)

    Kim, Ilsoo; Allen, Toby W.

    2012-04-01

    Free energy perturbation, a method for computing the free energy difference between two states, is often combined with non-Boltzmann biased sampling techniques in order to accelerate the convergence of free energy calculations. Here we present a new extension of the Bennett acceptance ratio (BAR) method by combining it with umbrella sampling (US) along a reaction coordinate in configurational space. In this approach, which we call Bennett acceptance ratio with umbrella sampling (BAR-US), the conditional histogram of energy difference (a mapping of the 3N-dimensional configurational space via a reaction coordinate onto 1D energy difference space) is weighted for marginalization with the associated population density along a reaction coordinate computed by US. This procedure produces marginal histograms of energy difference, from forward and backward simulations, with higher overlap in energy difference space, rendering free energy difference estimations using BAR statistically more reliable. In addition to BAR-US, two histogram analysis methods, termed Bennett overlapping histograms with US (BOH-US) and Bennett-Hummer (linear) least square with US (BHLS-US), are employed as consistency and convergence checks for free energy difference estimation by BAR-US. The proposed methods (BAR-US, BOH-US, and BHLS-US) are applied to a 1-dimensional asymmetric model potential, as has been used previously to test free energy calculations from non-equilibrium processes. We then consider the more stringent test of a 1-dimensional strongly (but linearly) shifted harmonic oscillator, which exhibits no overlap between two states when sampled using unbiased Brownian dynamics. We find that the efficiency of the proposed methods is enhanced over the original Bennett's methods (BAR, BOH, and BHLS) through fast uniform sampling of energy difference space via US in configurational space. We apply the proposed methods to the calculation of the electrostatic contribution to the absolute

  16. Method of using a nuclear magnetic resonance spectroscopy standard

    DOEpatents

    Spicer, Leonard D.; Bennett, Dennis W.; Davis, Jon F.

    1985-01-01

    (CH.sub.3).sub.3 SiNSO is produced by the reaction of ((CH.sub.3).sub.3 Si).sub.2 NH with SO.sub.2. Also produced in the reaction are ((CH.sub.3).sub.3 Si).sub.2 O and a new solid compound [NH.sub.4 ][(CH.sub.3).sub.3 SiOSO.sub.2 ]. Both (CH.sub.3).sub.3 SiNSO and [NH.sub.4 ][(CH.sub.3).sub.3 SiOSO.sub.2 ] have fluorescent properties. The reaction of the subject invention is used in a method of measuring the concentration of SO.sub.2 pollutants in gases. By the method, a sample of gas is bubbled through a solution of ((CH.sub.3).sub.3 Si).sub.2 NH, whereby any SO.sub.2 present in the gas will react to produce the two fluorescent products. The measured fluorescence of these products can then be used to calculate the concentration of SO.sub.2 in the original gas sample. The solid product [NH.sub.4 ][(CH.sub.3).sub.3 SiOSO.sub.2 ] may be used as a standard in solid state NMR spectroscopy, wherein the resonance peaks of either .sup.1 H, .sup.13 C, .sup.15 N, or .sup.29 Si may be used as a reference.

  17. Impact of saliva collection methods on sIgA and cortisol assays and acceptability to participants.

    PubMed

    Strazdins, Lyndall; Meyerkort, Shannon; Brent, Vicki; D'Souza, Rennie M; Broom, Dorothy H; Kyd, Jennelle M

    2005-12-20

    In community-based studies of stress and immunity, saliva samples offer a non-intrusive way of gathering biological data. Cotton-based devices are widely used in cortisol research, but some may affect assay results. We compared assay reliability and perceived acceptability of three saliva collection methods: passive, cotton 'salivettes' and cellulose-cotton tip 'eyespears'. Compared to passive collection, salivettes reduced the concentration of cortisol (p = .001) and sIgA (p = .002). Eyespears did not reduce cortisol or sIgA concentration, and showed less interference in the rank ordering of cortisol (r(eyespear with passive) = .90) and sIgA scores (r(eyespear with passive) = .96) compared to salivettes (r cortisol(salivette with passive) = .79; r sIgA(salivette with passive) = .66). The comfort and acceptability of both cotton-based devices were rated positively. Cotton-cellulose eyespears could offer methodological advantages for collecting saliva to measure cortisol and sIgA levels, and, because they can be held during sampling, may be useful for research with children and the frail elderly.

  18. Maximizing acceptability and usefulness of an automated telephone intervention: Lessons from a developmental mixed-methods approach.

    PubMed

    Schneider, Jennifer; Waterbury, Amy; Feldstein, Adrianne; Donovan, Jerena; Vollmer, William M; Dubanoski, Joan; Clark, Shelley; Rand, Cynthia

    2011-03-01

    The objective was to describe the utility of mixed methods to inform the development of an automated telephone intervention to improve patients' compliance with asthma medication. As part of intervention development for a larger trial, we conducted 15 focus groups (n = 53) to design and develop calls, and to identify factors influencing intervention acceptability and usefulness. We piloted four call types and interviewed 64 participants to further improve call content and receptivity to the intervention. Feedback led to several changes to the intervention scripts and eventual calls, and an initial pilot led us to drop one of the calls. During the pilot, we reached 43 percent of target participants; 74 percent of those stayed on the call until it ended. This process provided key insights about automated calls, and may have broader applicability for the development of automated interventions designed to help patients manage a variety of chronic conditions. PMID:25133772

  19. Standard methods for filled hole tension testing of textile composites

    NASA Technical Reports Server (NTRS)

    Portanova, M. A.; Masters, J. E.

    1995-01-01

    The effects of two test specimen geometry parameters, the specimen width and W/D ratio, on filled-hole tensile strength were determined for textile composite materials. Test data generated by Boeing and Lockheed on 2-D and 3-D braids, and 3-D weaves were used to make these evaluations. The investigation indicated that filled-hole tensile-strength showed little sensitivity to either parameter. Test specimen configurations used in open-hole tension tests, such as those suggested by ASTM D5766 - Standard Test Method for Open Hole Tensile Strength of Polymer Matrix Composite Laminates or those proposed by MIL-HDBK-17-lD should provide adequate results for material comparisons studies. Comparisons of the materials' open-hole and filled-hole tensile strengths indicated that the latter were generally lower than the former. The 3-D braids were the exception; their filled-hole strengths were unexpected larger than their open-hole strengths. However, these increases were small compared to the scatter in the data. Thus, filled hole tension may be a critical design consideration for textile composite materials.

  20. Coordinate measuring machine test standard apparatus and method

    DOEpatents

    Bieg, Lothar F.

    1994-08-30

    A coordinate measuring machine test standard apparatus and method which iudes a rotary spindle having an upper phase plate and an axis of rotation, a kinematic ball mount attached to the phase plate concentric with the axis of rotation of the phase plate, a groove mounted at the circumference of the phase plate, and an arm assembly which rests in the groove. The arm assembly has a small sphere at one end and a large sphere at the other end. The small sphere may be a coordinate measuring machine probe tip and may have variable diameters. The large sphere is secured in the kinematic ball mount and the arm is held in the groove. The kinematic ball mount includes at least three mounting spheres and the groove is an angular locating groove including at least two locking spheres. The arm may have a hollow inner core and an outer layer. The rotary spindle may be a ratio reducer. The device is used to evaluate the measuring performance of a coordinate measuring machine for periodic recertification, including 2 and 3 dimensional accuracy, squareness, straightness, and angular accuracy.

  1. Coordinate measuring machine test standard apparatus and method

    DOEpatents

    Bieg, L.F.

    1994-08-30

    A coordinate measuring machine test standard apparatus and method are disclosed which includes a rotary spindle having an upper phase plate and an axis of rotation, a kinematic ball mount attached to the phase plate concentric with the axis of rotation of the phase plate, a groove mounted at the circumference of the phase plate, and an arm assembly which rests in the groove. The arm assembly has a small sphere at one end and a large sphere at the other end. The small sphere may be a coordinate measuring machine probe tip and may have variable diameters. The large sphere is secured in the kinematic ball mount and the arm is held in the groove. The kinematic ball mount includes at least three mounting spheres and the groove is an angular locating groove including at least two locking spheres. The arm may have a hollow inner core and an outer layer. The rotary spindle may be a ratio reducer. The device is used to evaluate the measuring performance of a coordinate measuring machine for periodic recertification, including 2 and 3 dimensional accuracy, squareness, straightness, and angular accuracy. 5 figs.

  2. Workshop on laboratory protocol standards for the Molecular Methods Database.

    PubMed

    Klingström, Tomas; Soldatova, Larissa; Stevens, Robert; Roos, T Erik; Swertz, Morris A; Müller, Kristian M; Kalaš, Matúš; Lambrix, Patrick; Taussig, Michael J; Litton, Jan-Eric; Landegren, Ulf; Bongcam-Rudloff, Erik

    2013-01-25

    Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point. PMID:22687389

  3. Standard Methods for the Management of Immunogenetic Data

    PubMed Central

    Gourraud, Pierre-Antoine; Hollenbach, Jill A.; Barnetche, Thomas; Single, Richard M.; Mack, Steven J.

    2014-01-01

    In this chapter, we outline some basic principles for the consistent management of immunogenetic data. These include the preparation of a single master data file that can serve as the basis for all subsequent analyses, a focus on the quality and homogeneity of the data to be analyzed, the documentation of the coding systems used to represent the data, and the application of nomenclature standards specific for each immunogenetic system being evaluated. The data management principles discussed here are intended to provide a foundation for the data analysis methods detailed in Chaps. 13 and 14. The relationship between the data management and analysis methods covered in these three chapters is illustrated in Figure 1. The application of these data management principles is a first step toward consistent and reproducible data analyses. While it may take extra time and effort to apply them, we feel that it is better to take this approach than to assume that low data quality can be compensated for by large sample sizes. In addition to their relevance for analytical reproducibility, it is important to consider these data management principles from an ethical perspective. The reliability of the data collected and generated as part of a research study should be as important a component of the ethical review of a research application as the security of those data. Finally, in addition to ensuring the integrity of the data from collection to publication, the application of these data management principles will provide a means to foster research integrity and to improve the potential for collaborative data sharing. PMID:22665236

  4. The Standardized Candle Method for Type II-Plateau Supernovae

    NASA Astrophysics Data System (ADS)

    Olivares, Felipe; Hamuy, Mario

    The determination of extragalactic distances allows us to constrain the cosmological parameters which drive the universe dynamics. The large luminosities of type II supernovae (SNe) (those with a hydrogen-rich envelope) make this class of objects as interesting distance indicators. Their luminosities can be standardized using the expansion velocity of the photosphere estimated from P-Cygni line profiles. However, one of the problems that hampers their use in distance determinations is the uncertainty in the host-galaxy extinction. The physics of the photosphere suggests the existence of a unique asymptotic color for all SNe toward the end of the optically thick phase (which corresponds to a period of constant luminosity of about 100 days called plateau). The purpose of this work is to examine the validity of this hypothesis and to contruct Hubble diagrams standardizing the luminosities of these objects. A usual problem with the measurement of such asymptotic color is that there is no obvious maximum during the plateau phase (unlike their cousins, the type Ia SNe), so it proves hard to bring all light curves to the same time scale. One way around this is to use the end of the plateau as an estimate of the time origin for each event. This time origin also serves as a uniform reference epoch to measure magnitudes and expansion velocities. Although simple in theory, in practice it is usually hard to measure magnitudes, colors and expansion velocities owing to the coarse sampling of the observations. Thus, our aims are 1) perform adequate fits to the light, color and velocity curves, 2) determine the asymptotic color, 3) explore the usefulness of such color as reddening indicator, 4) calibrate the relation between luminosity and expansion velocity, and 5) measure distances, which will lead us to the contruction a Hubble diagram. In this talk we present fits made by means of analytic function modeling. We discuss the usefulness of the (V-R) and (V-I) colors for the

  5. An Empirical Comparison of Variable Standardization Methods in Cluster Analysis.

    ERIC Educational Resources Information Center

    Schaffer, Catherine M.; Green, Paul E.

    1996-01-01

    The common marketing research practice of standardizing the columns of a persons-by-variables data matrix prior to clustering the entities corresponding to the rows was evaluated with 10 large-scale data sets. Results indicate that the column standardization practice may be problematic for some kinds of data that marketing researchers used for…

  6. Acceptability of Three Novel HIV Prevention Methods Among Young Male and Transgender Female Sex Workers in Puerto Rico.

    PubMed

    Giguere, Rebecca; Frasca, Timothy; Dolezal, Curtis; Febo, Irma; Cranston, Ross D; Mayer, Kenneth; McGowan, Ian; Carballo-Diéguez, Alex

    2016-10-01

    Sex workers need HIV-prevention methods they can control and incorporate easily in their work. We studied the acceptability of three methods: HIV self-test use with clients, oral pre-exposure prophylaxis (PrEP), and rectal microbicide gel. Four male and eight transgender female (TGF) sex workers in Puerto Rico completed a baseline survey with a quantitative measure of likelihood of use. From them, one male and four TGF also completed a 12-week study of rectal microbicide placebo gel use prior to receptive anal intercourse with male clients and evaluated via qualitative in-depth interviews and follow-up quantitative assessments how each method could be incorporated into their work. Most were interested in a rectal microbicide gel and able to use it covertly with clients. Challenges to using the HIV self-test with clients included the potential for both breach of confidentiality and confronting violent situations. Participants also expressed interest in oral PrEP, but raised concerns about side effects.

  7. Acceptability of Three Novel HIV Prevention Methods Among Young Male and Transgender Female Sex Workers in Puerto Rico.

    PubMed

    Giguere, Rebecca; Frasca, Timothy; Dolezal, Curtis; Febo, Irma; Cranston, Ross D; Mayer, Kenneth; McGowan, Ian; Carballo-Diéguez, Alex

    2016-10-01

    Sex workers need HIV-prevention methods they can control and incorporate easily in their work. We studied the acceptability of three methods: HIV self-test use with clients, oral pre-exposure prophylaxis (PrEP), and rectal microbicide gel. Four male and eight transgender female (TGF) sex workers in Puerto Rico completed a baseline survey with a quantitative measure of likelihood of use. From them, one male and four TGF also completed a 12-week study of rectal microbicide placebo gel use prior to receptive anal intercourse with male clients and evaluated via qualitative in-depth interviews and follow-up quantitative assessments how each method could be incorporated into their work. Most were interested in a rectal microbicide gel and able to use it covertly with clients. Challenges to using the HIV self-test with clients included the potential for both breach of confidentiality and confronting violent situations. Participants also expressed interest in oral PrEP, but raised concerns about side effects. PMID:27048236

  8. The History of Infant Formula: Quality, Safety, and Standard Methods.

    PubMed

    Wargo, Wayne F

    2016-01-01

    Food-related laws and regulations have existed since ancient times. Egyptian scrolls prescribed the labeling needed for certain foods. In ancient Athens, beer and wines were inspected for purity and soundness, and the Romans had a well-organized state food control system to protect consumers from fraud or bad produce. In Europe during the Middle Ages, individual countries passed laws concerning the quality and safety of eggs, sausages, cheese, beer, wine, and bread; some of these laws still exist today. But more modern dietary guidelines and food regulations have their origins in the latter half of the 19th century when the first general food laws were adopted and basic food control systems were implemented to monitor compliance. Around this time, science and food chemistry began to provide the tools to determine "purity" of food based primarily on chemical composition and to determine whether it had been adulterated in any way. Since the key chemical components of mammalian milk were first understood, infant formulas have steadily advanced in complexity as manufacturers attempt to close the compositional gap with human breast milk. To verify these compositional innovations and ensure product quality and safety, infant formula has become one of the most regulated foods in the world. The present paper examines the historical development of nutritional alternatives to breastfeeding, focusing on efforts undertaken to ensure the quality and safety from antiquity to present day. The impact of commercial infant formulas on global regulations is addressed, along with the resulting need for harmonized, fit-for-purpose, voluntary consensus standard methods. PMID:26811237

  9. The History of Infant Formula: Quality, Safety, and Standard Methods.

    PubMed

    Wargo, Wayne F

    2016-01-01

    Food-related laws and regulations have existed since ancient times. Egyptian scrolls prescribed the labeling needed for certain foods. In ancient Athens, beer and wines were inspected for purity and soundness, and the Romans had a well-organized state food control system to protect consumers from fraud or bad produce. In Europe during the Middle Ages, individual countries passed laws concerning the quality and safety of eggs, sausages, cheese, beer, wine, and bread; some of these laws still exist today. But more modern dietary guidelines and food regulations have their origins in the latter half of the 19th century when the first general food laws were adopted and basic food control systems were implemented to monitor compliance. Around this time, science and food chemistry began to provide the tools to determine "purity" of food based primarily on chemical composition and to determine whether it had been adulterated in any way. Since the key chemical components of mammalian milk were first understood, infant formulas have steadily advanced in complexity as manufacturers attempt to close the compositional gap with human breast milk. To verify these compositional innovations and ensure product quality and safety, infant formula has become one of the most regulated foods in the world. The present paper examines the historical development of nutritional alternatives to breastfeeding, focusing on efforts undertaken to ensure the quality and safety from antiquity to present day. The impact of commercial infant formulas on global regulations is addressed, along with the resulting need for harmonized, fit-for-purpose, voluntary consensus standard methods.

  10. HUMAN FECAL SOURCE IDENTIFICATION: REAL-TIME QUANTITATIVE PCR METHOD STANDARDIZATION - abstract

    EPA Science Inventory

    Method standardization or the formal development of a protocol that establishes uniform performance benchmarks and practices is necessary for widespread adoption of a fecal source identification approach. Standardization of a human-associated fecal identification method has been...

  11. Human Fecal Source Identification: Real-Time Quantitative PCR Method Standardization

    EPA Science Inventory

    Method standardization or the formal development of a protocol that establishes uniform performance benchmarks and practices is necessary for widespread adoption of a fecal source identification approach. Standardization of a human-associated fecal identification method has been...

  12. Enhanced Sampling in Free Energy Calculations: Combining SGLD with the Bennett's Acceptance Ratio and Enveloping Distribution Sampling Methods.

    PubMed

    König, Gerhard; Miller, Benjamin T; Boresch, Stefan; Wu, Xiongwu; Brooks, Bernard R

    2012-10-01

    One of the key requirements for the accurate calculation of free energy differences is proper sampling of conformational space. Especially in biological applications, molecular dynamics simulations are often confronted with rugged energy surfaces and high energy barriers, leading to insufficient sampling and, in turn, poor convergence of the free energy results. In this work, we address this problem by employing enhanced sampling methods. We explore the possibility of using self-guided Langevin dynamics (SGLD) to speed up the exploration process in free energy simulations. To obtain improved free energy differences from such simulations, it is necessary to account for the effects of the bias due to the guiding forces. We demonstrate how this can be accomplished for the Bennett's acceptance ratio (BAR) and the enveloping distribution sampling (EDS) methods. While BAR is considered among the most efficient methods available for free energy calculations, the EDS method developed by Christ and van Gunsteren is a promising development that reduces the computational costs of free energy calculations by simulating a single reference state. To evaluate the accuracy of both approaches in connection with enhanced sampling, EDS was implemented in CHARMM. For testing, we employ benchmark systems with analytical reference results and the mutation of alanine to serine. We find that SGLD with reweighting can provide accurate results for BAR and EDS where conventional molecular dynamics simulations fail. In addition, we compare the performance of EDS with other free energy methods. We briefly discuss the implications of our results and provide practical guidelines for conducting free energy simulations with SGLD.

  13. Standardized Analytical Methods for Environmental Restoration Following Homeland Security Events

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Methodology was formulated for use in the event of a terrorist attack using a variety of chemical, radioactive, biological, and toxic agents. Standardized analysis procedures were determined for use should these events occur. This publication is annually updated....

  14. MICROORGANISMS IN BIOSOLIDS: ANALYTICAL METHODS DEVELOPMENT, STANDARDIZATION, AND VALIDATION

    EPA Science Inventory

    The objective of this presentation is to discuss pathogens of concern in biosolids, the analytical techniques used to evaluate microorganisms in biosolids, and to discuss standardization and validation of analytical protocols for microbes within such a complex matrix. Implicatio...

  15. 29 CFR 1630.7 - Standards, criteria, or methods of administration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Standards, criteria, or methods of administration. 1630.7... Standards, criteria, or methods of administration. It is unlawful for a covered entity to use standards, criteria, or methods of administration, which are not job-related and consistent with business...

  16. 42 CFR 440.260 - Methods and standards to assure quality of services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Methods and standards to assure quality of services... and Limits Applicable to All Services § 440.260 Methods and standards to assure quality of services. The plan must include a description of methods and standards used to assure that services are of...

  17. Standardization of chemical analytical techniques for pyrolysis bio-oil: history, challenges, and current status of methods

    DOE PAGES

    Ferrell, Jack R.; Olarte, Mariefel V.; Christensen, Earl D.; Padmaperuma, Asanga B.; Connatser, Raynella M.; Stankovikj, Filip; Meier, Dietrich; Paasikallio, Ville

    2016-07-05

    Here, we discuss the standardization of analytical techniques for pyrolysis bio-oils, including the current status of methods, and our opinions on future directions. First, the history of past standardization efforts is summarized, and both successful and unsuccessful validation of analytical techniques highlighted. The majority of analytical standardization studies to-date has tested only physical characterization techniques. In this paper, we present results from an international round robin on the validation of chemical characterization techniques for bio-oils. Techniques tested included acid number, carbonyl titrations using two different methods (one at room temperature and one at 80 °C), 31P NMR for determination ofmore » hydroxyl groups, and a quantitative gas chromatography–mass spectrometry (GC-MS) method. Both carbonyl titration and acid number methods have yielded acceptable inter-laboratory variabilities. 31P NMR produced acceptable results for aliphatic and phenolic hydroxyl groups, but not for carboxylic hydroxyl groups. As shown in previous round robins, GC-MS results were more variable. Reliable chemical characterization of bio-oils will enable upgrading research and allow for detailed comparisons of bio-oils produced at different facilities. Reliable analytics are also needed to enable an emerging bioenergy industry, as processing facilities often have different analytical needs and capabilities than research facilities. We feel that correlations in reliable characterizations of bio-oils will help strike a balance between research and industry, and will ultimately help to -determine metrics for bio-oil quality. Lastly, the standardization of additional analytical methods is needed, particularly for upgraded bio-oils.« less

  18. 20 CFR 602.21 - Standard methods and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... demographic data will be limited to those data which relate to an individual's eligibility for UC benefits and... investigations to determine the degree of accuracy and timeliness in the administration of the State UC law and... determinations with respect to individual benefit claims in accordance with the Secretary's “Standard for...

  19. 20 CFR 602.21 - Standard methods and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... demographic data will be limited to those data which relate to an individual's eligibility for UC benefits and... investigations to determine the degree of accuracy and timeliness in the administration of the State UC law and... determinations with respect to individual benefit claims in accordance with the Secretary's “Standard for...

  20. 20 CFR 602.21 - Standard methods and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... demographic data will be limited to those data which relate to an individual's eligibility for UC benefits and... investigations to determine the degree of accuracy and timeliness in the administration of the State UC law and... determinations with respect to individual benefit claims in accordance with the Secretary's “Standard for...

  1. 20 CFR 602.21 - Standard methods and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... demographic data will be limited to those data which relate to an individual's eligibility for UC benefits and... investigations to determine the degree of accuracy and timeliness in the administration of the State UC law and... determinations with respect to individual benefit claims in accordance with the Secretary's “Standard for...

  2. 20 CFR 602.21 - Standard methods and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... demographic data will be limited to those data which relate to an individual's eligibility for UC benefits and... investigations to determine the degree of accuracy and timeliness in the administration of the State UC law and... determinations with respect to individual benefit claims in accordance with the Secretary's “Standard for...

  3. Alignment of Standards and Assessment: A Theoretical and Empirical Study of Methods for Alignment

    ERIC Educational Resources Information Center

    Nasstrom, Gunilla; Henriksson, Widar

    2008-01-01

    Introduction: In a standards-based school-system alignment of policy documents with standards and assessment is important. To be able to evaluate whether schools and students have reached the standards, the assessment should focus on the standards. Different models and methods can be used for measuring alignment, i.e. the correspondence between…

  4. A practical method of estimating standard error of age in the fission track dating method

    USGS Publications Warehouse

    Johnson, N.M.; McGee, V.E.; Naeser, C.W.

    1979-01-01

    A first-order approximation formula for the propagation of error in the fission track age equation is given by PA = C[P2s+P2i+P2??-2rPsPi] 1 2, where PA, Ps, Pi and P?? are the percentage error of age, of spontaneous track density, of induced track density, and of neutron dose, respectively, and C is a constant. The correlation, r, between spontaneous are induced track densities is a crucial element in the error analysis, acting generally to improve the standard error of age. In addition, the correlation parameter r is instrumental is specifying the level of neutron dose, a controlled variable, which will minimize the standard error of age. The results from the approximation equation agree closely with the results from an independent statistical model for the propagation of errors in the fission-track dating method. ?? 1979.

  5. A STANDARDIZED ASSESSMENT METHOD (SAM) FOR RIVERINE MACROINVERTEBRATES

    EPA Science Inventory

    A macroinvertebrate sampling method for large rivers based on desirable characteristics of existing nonwadeable methods was developed and tested. Six sites each were sampled on the Great Miami and Kentucky Rivers, reflecting a human disturbance gradient. Samples were collected ...

  6. Tissue sampling methods and standards for vertebrate genomics

    PubMed Central

    2012-01-01

    The recent rise in speed and efficiency of new sequencing technologies have facilitated high-throughput sequencing, assembly and analyses of genomes, advancing ongoing efforts to analyze genetic sequences across major vertebrate groups. Standardized procedures in acquiring high quality DNA and RNA and establishing cell lines from target species will facilitate these initiatives. We provide a legal and methodological guide according to four standards of acquiring and storing tissue for the Genome 10K Project and similar initiatives as follows: four-star (banked tissue/cell cultures, RNA from multiple types of tissue for transcriptomes, and sufficient flash-frozen tissue for 1 mg of DNA, all from a single individual); three-star (RNA as above and frozen tissue for 1 mg of DNA); two-star (frozen tissue for at least 700 μg of DNA); and one-star (ethanol-preserved tissue for 700 μg of DNA or less of mixed quality). At a minimum, all tissues collected for the Genome 10K and other genomic projects should consider each species’ natural history and follow institutional and legal requirements. Associated documentation should detail as much information as possible about provenance to ensure representative sampling and subsequent sequencing. Hopefully, the procedures outlined here will not only encourage success in the Genome 10K Project but also inspire the adaptation of standards by other genomic projects, including those involving other biota. PMID:23587255

  7. Comparing Yes/No Angoff and Bookmark Standard Setting Methods in the Context of English Assessment

    ERIC Educational Resources Information Center

    Hsieh, Mingchuan

    2013-01-01

    The Yes/No Angoff and Bookmark method for setting standards on educational assessment are currently two of the most popular standard-setting methods. However, there is no research into the comparability of these two methods in the context of language assessment. This study compared results from the Yes/No Angoff and Bookmark methods as applied to…

  8. Elementary Science Methods Courses and the "National Science Education Standards": Are We Adequately Preparing Teachers?

    ERIC Educational Resources Information Center

    Smith, Leigh K.; Gess-Newsome, Julie

    2004-01-01

    Despite the apparent lack of universally accepted goals or objectives for elementary science methods courses, teacher educators nationally are autonomously designing these classes to prepare prospective teachers to teach science. It is unclear, however, whether science methods courses are preparing teachers to teach science effectively or to…

  9. BSAC standardized disc susceptibility testing method (version 8).

    PubMed

    Andrews, J M

    2009-09-01

    azithromycin, clarithromycin, erythromycin and telithromycin (Table 15); clarithromycin and erythromycin MIC and zone diameter BPs for Moraxella catarrhalis (Table 16); azithromycin MIC BPs for Neisseria gonorrhoeae (Table 17); chloramphenicol and rifampicin MIC BPs for Neisseria meningitidis (Table 18); azithromycin MIC BPs for Haemophilus influenzae (Table 19); MIC BPs for metronidazole for Bacteroides fragilis, Bacteroides thetaiotaomicron and Clostridium perfringens (Tables 23-25, respectively); susceptibility testing of Listeria spp. (Appendix 3); the acceptable range for ATCC 25923 to a 10 microg tobramycin disc (Table 26).

  10. Standardized development of computer software. Part 1: Methods

    NASA Technical Reports Server (NTRS)

    Tausworthe, R. C.

    1976-01-01

    This work is a two-volume set on standards for modern software engineering methodology. This volume presents a tutorial and practical guide to the efficient development of reliable computer software, a unified and coordinated discipline for design, coding, testing, documentation, and project organization and management. The aim of the monograph is to provide formal disciplines for increasing the probability of securing software that is characterized by high degrees of initial correctness, readability, and maintainability, and to promote practices which aid in the consistent and orderly development of a total software system within schedule and budgetary constraints. These disciplines are set forth as a set of rules to be applied during software development to drastically reduce the time traditionally spent in debugging, to increase documentation quality, to foster understandability among those who must come in contact with it, and to facilitate operations and alterations of the program as requirements on the program environment change.

  11. Acceptance of an assistive robot in older adults: a mixed-method study of human–robot interaction over a 1-month period in the Living Lab setting

    PubMed Central

    Wu, Ya-Huei; Wrobel, Jérémy; Cornuet, Mélanie; Kerhervé, Hélène; Damnée, Souad; Rigaud, Anne-Sophie

    2014-01-01

    Background There is growing interest in investigating acceptance of robots, which are increasingly being proposed as one form of assistive technology to support older adults, maintain their independence, and enhance their well-being. In the present study, we aimed to observe robot-acceptance in older adults, particularly subsequent to a 1-month direct experience with a robot. Subjects and methods Six older adults with mild cognitive impairment (MCI) and five cognitively intact healthy (CIH) older adults were recruited. Participants interacted with an assistive robot in the Living Lab once a week for 4 weeks. After being shown how to use the robot, participants performed tasks to simulate robot use in everyday life. Mixed methods, comprising a robot-acceptance questionnaire, semistructured interviews, usability-performance measures, and a focus group, were used. Results Both CIH and MCI subjects were able to learn how to use the robot. However, MCI subjects needed more time to perform tasks after a 1-week period of not using the robot. Both groups rated similarly on the robot-acceptance questionnaire. They showed low intention to use the robot, as well as negative attitudes toward and negative images of this device. They did not perceive it as useful in their daily life. However, they found it easy to use, amusing, and not threatening. In addition, social influence was perceived as powerful on robot adoption. Direct experience with the robot did not change the way the participants rated robots in their acceptance questionnaire. We identified several barriers to robot-acceptance, including older adults’ uneasiness with technology, feeling of stigmatization, and ethical/societal issues associated with robot use. Conclusion It is important to destigmatize images of assistive robots to facilitate their acceptance. Universal design aiming to increase the market for and production of products that are usable by everyone (to the greatest extent possible) might help to

  12. Standard methods for research on apis mellifera gut symbionts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Gut microbes can play an important role in digestion, disease resistance, and the general health of animals, but little is known about the biology of gut symbionts in Apis mellifera. This paper is part of a series on honey bee research methods, providing protocols for studying gut symbionts. We desc...

  13. Standard methods for research on Apis mellifera gut symbionts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Gut microbes can play an important role in digestion, disease resistance, and the general health of animals, but little is known about the biology of gut symbionts in Apis mellifera. This paper is part of a series on honey bee research methods, providing protocols for studying gut symbionts. We desc...

  14. Quantifying uncertainty of determination by standard additions and serial dilutions methods taking into account standard uncertainties in both axes.

    PubMed

    Hyk, Wojciech; Stojek, Zbigniew

    2013-06-18

    The analytical expressions for the calculation of the standard uncertainty of the predictor variable either extrapolated or interpolated from a calibration line that takes into account uncertainties in both axes have been derived and successfully verified using the Monte Carlo modeling. These expressions are essential additions to the process of the analyte quantification realized with either the method of standard additions (SAM) or the method of serial dilutions (MSD). The latter one has been proposed as an alternative approach to the SAM procedure. In the MSD approach instead of the sequence of standard additions, the sequence of solvent additions to the spiked sample is performed. The comparison of the calculation results based on the expressions derived to their equivalents obtained from the Monte Carlo simulation, applied to real experimental data sets, confirmed that these expressions are valid in real analytical practice. The estimation of the standard uncertainty of the analyte concentration, quantified via either SAM or MSD or simply a calibration curve, is of great importance for the construction of the uncertainty budget of an analytical procedure. The correct estimation of the standard uncertainty of the analyte concentration is a key issue in the quality assurance in the instrumental analysis.

  15. Using FTIR-ATR Spectroscopy to Teach the Internal Standard Method

    ERIC Educational Resources Information Center

    Bellamy, Michael K.

    2010-01-01

    The internal standard method is widely applied in quantitative analyses. However, most analytical chemistry textbooks either omit this topic or only provide examples of a single-point internal standardization. An experiment designed to teach students how to prepare an internal standard calibration curve is described. The experiment is a modified…

  16. Mitochondrial Structure and Function Are Disrupted by Standard Isolation Methods

    PubMed Central

    Picard, Martin; Taivassalo, Tanja; Ritchie, Darmyn; Wright, Kathryn J.; Thomas, Melissa M.; Romestaing, Caroline; Hepple, Russell T.

    2011-01-01

    Mitochondria regulate critical components of cellular function via ATP production, reactive oxygen species production, Ca2+ handling and apoptotic signaling. Two classical methods exist to study mitochondrial function of skeletal muscles: isolated mitochondria and permeabilized myofibers. Whereas mitochondrial isolation removes a portion of the mitochondria from their cellular environment, myofiber permeabilization preserves mitochondrial morphology and functional interactions with other intracellular components. Despite this, isolated mitochondria remain the most commonly used method to infer in vivo mitochondrial function. In this study, we directly compared measures of several key aspects of mitochondrial function in both isolated mitochondria and permeabilized myofibers of rat gastrocnemius muscle. Here we show that mitochondrial isolation i) induced fragmented organelle morphology; ii) dramatically sensitized the permeability transition pore sensitivity to a Ca2+ challenge; iii) differentially altered mitochondrial respiration depending upon the respiratory conditions; and iv) dramatically increased H2O2 production. These alterations are qualitatively similar to the changes in mitochondrial structure and function observed in vivo after cellular stress-induced mitochondrial fragmentation, but are generally of much greater magnitude. Furthermore, mitochondrial isolation markedly altered electron transport chain protein stoichiometry. Collectively, our results demonstrate that isolated mitochondria possess functional characteristics that differ fundamentally from those of intact mitochondria in permeabilized myofibers. Our work and that of others underscores the importance of studying mitochondrial function in tissue preparations where mitochondrial structure is preserved and all mitochondria are represented. PMID:21512578

  17. Standardization of Laser Methods and Techniques for Vibration Measurements and Calibrations

    SciTech Connect

    Martens, Hans-Juergen von

    2010-05-28

    The realization and dissemination of the SI units of motion quantities (vibration and shock) have been based on laser interferometer methods specified in international documentary standards. New and refined laser methods and techniques developed by national metrology institutes and by leading manufacturers in the past two decades have been swiftly specified as standard methods for inclusion into in the series ISO 16063 of international documentary standards. A survey of ISO Standards for the calibration of vibration and shock transducers demonstrates the extended ranges and improved accuracy (measurement uncertainty) of laser methods and techniques for vibration and shock measurements and calibrations. The first standard for the calibration of laser vibrometers by laser interferometry or by a reference accelerometer calibrated by laser interferometry (ISO 16063-41) is on the stage of a Draft International Standard (DIS) and may be issued by the end of 2010. The standard methods with refined techniques proved to achieve wider measurement ranges and smaller measurement uncertainties than that specified in the ISO Standards. The applicability of different standardized interferometer methods to vibrations at high frequencies was recently demonstrated up to 347 kHz (acceleration amplitudes up to 350 km/s{sup 2}). The relative deviations between the amplitude measurement results of the different interferometer methods that were applied simultaneously, differed by less than 1% in all cases.

  18. Standardization of Laser Methods and Techniques for Vibration Measurements and Calibrations

    NASA Astrophysics Data System (ADS)

    von Martens, Hans-Jürgen

    2010-05-01

    The realization and dissemination of the SI units of motion quantities (vibration and shock) have been based on laser interferometer methods specified in international documentary standards. New and refined laser methods and techniques developed by national metrology institutes and by leading manufacturers in the past two decades have been swiftly specified as standard methods for inclusion into in the series ISO 16063 of international documentary standards. A survey of ISO Standards for the calibration of vibration and shock transducers demonstrates the extended ranges and improved accuracy (measurement uncertainty) of laser methods and techniques for vibration and shock measurements and calibrations. The first standard for the calibration of laser vibrometers by laser interferometry or by a reference accelerometer calibrated by laser interferometry (ISO 16063-41) is on the stage of a Draft International Standard (DIS) and may be issued by the end of 2010. The standard methods with refined techniques proved to achieve wider measurement ranges and smaller measurement uncertainties than that specified in the ISO Standards. The applicability of different standardized interferometer methods to vibrations at high frequencies was recently demonstrated up to 347 kHz (acceleration amplitudes up to 350 km/s2). The relative deviations between the amplitude measurement results of the different interferometer methods that were applied simultaneously, differed by less than 1% in all cases.

  19. Comparison of EPA Method 1615 RT-qPCR Assays in Standard and Kit Format

    EPA Science Inventory

    EPA Method 1615 contains protocols for measuring enterovirus and norovirus by reverse transcription quantitative polymerase chain reaction. A commercial kit based upon these protocols was designed and compared to the method's standard approach. Reagent grade, secondary effluent, ...

  20. Development of standard test methods for evaluating defibrillation recovery characteristics of disposable ECG electrodes.

    PubMed

    Schoenberg, A A; Booth, H E; Lyon, P C

    1979-01-01

    A clinically relevant test for the measurement of defibrillation overload recovery of prefilled disposable ECG electrodes was developed and is proposed for use in an ECG electrode standard under development by AAMI. Defibrillation overload voltages and currents, as well as electrode polarization recovery voltages, were first measured in animal tests on 12 types of electrodes to allow correlation with various bench tests using a capacitor discharge at 10, 200, or 1000 V. Current overloads absorbed by the electrodes under worst conditions in animal tests were in the range of 2 percent of the defibrillation current flowing through the chest. These overloads were absorbed by most Ag-AgCl electrodes without excessive polarization. However, stainless steel, brass, and tin electrodes tended to polarize to levels that would saturate many ECG monitors. A standard bench test using a 200-V 10-muF capacitor was recommended for inclusion in the AAMI standard to determine whether electrodes are acceptable for use during defibrillation.

  1. A Monte Carlo Investigation of the Contrasting Groups Standard Setting Method.

    ERIC Educational Resources Information Center

    Cizek, Gregory J.; Husband, Timothy H.

    The contrasting groups method is one of many possible methods for setting passing scores. The most commonly used method is probably that developed by W. H. Angoff (1971), but it has been suggested that the Angoff method may not be appropriate for many standard setting applications in education. The contrasting groups method is explored as an…

  2. Web-based virtual microscopy at the RWTH Aachen University: didactic concept, methods and analysis of acceptance by the students.

    PubMed

    Merk, Magdalene; Knuechel, Ruth; Perez-Bouza, Alberto

    2010-12-20

    Fundamental knowledge of microscopic anatomy and pathology has always been an essential part in medical education. The traditional didactic concept comprises theoretical and practical lessons using a light microscope and glass slides. High-speed Internet connections and technical improvement in whole-slide digital microscopy (commonly termed "virtual microscopy") provide a new and attractive approach for both teachers and students. High picture quality and unlimited temporal and spatial availability of histology samples from different fields are key advantages of web-based digital microscopy. In this report we discuss the technical requirements, system efficiency, optical resolution and didactic concept. Furthermore, we present a review of the experience gained in the course of one year based on an analysis of student acceptance. Three groups with a total of 192 students between the 3rd and 5th year of medical studies attending the practical courses of general and advanced histopathology had access to both glass-mounted and digitalized slides. Prior to exams, students were asked to answer an anonymous questionnaire. The results of the study reflect the high acceptance and intensive use of the web-based digital histology by students, thus encouraging the development of further Web-based learning strategies for the teaching of histology and pathology.

  3. Using Resampling To Estimate the Precision of an Empirical Standard-Setting Method.

    ERIC Educational Resources Information Center

    Muijtjens, Arno M. M.; Kramer, Anneke W. M.; Kaufman, David M.; Van der Vleuten, Cees P. M.

    2003-01-01

    Developed a method to estimate the cutscore precisions for empirical standard-setting methods by using resampling. Illustrated the method with two actual datasets consisting of 86 Dutch medical residents and 155 Canadian medical students taking objective structured clinical examinations. Results show the applicability of the method. (SLD)

  4. A mixed-methods pilot study of the acceptability and effectiveness of a brief meditation and mindfulness intervention for people with diabetes and coronary heart disease.

    PubMed

    Keyworth, Chris; Knopp, Jasmin; Roughley, Kate; Dickens, Chris; Bold, Stuart; Coventry, Peter

    2014-01-01

    Mindfulness-based interventions can successfully target negative perseverative cognitions such as worry and thought suppression, but their acceptability and effectiveness in people with long-term conditions is uncertain. We therefore pilot tested a six-week meditation and mindfulness intervention in people (n = 40) with diabetes mellitus and coronary heart disease. We used a sequential mixed-methods approach that measured change in worry and thought suppression and qualitatively explored acceptability, feasibility, and user experience with a focus group (n = 11) and in-depth interviews (n = 16). The intervention was highly acceptable, with 90% completing ≥5 sessions. Meditation and mindfulness skills led to improved sleep, greater relaxation, and more-accepting approaches to illness and illness experience. At the end of the six-week meditation course, worry, and thought suppression were significantly reduced. Positive impacts of mindfulness-based interventions on psychological health may relate to acquisition and development of meta-cognitive skills but this needs experimental confirmation.

  5. A Mixed-Methods Pilot Study of the Acceptability and Effectiveness of a Brief Meditation and Mindfulness Intervention for People with Diabetes and Coronary Heart Disease

    PubMed Central

    Keyworth, Chris; Knopp, Jasmin; Roughley, Kate; Dickens, Chris; Bold, Stuart; Coventry, Peter

    2014-01-01

    Mindfulness-based interventions can successfully target negative perseverative cognitions such as worry and thought suppression, but their acceptability and effectiveness in people with long-term conditions is uncertain. We therefore pilot tested a six-week meditation and mindfulness intervention in people (n = 40) with diabetes mellitus and coronary heart disease. We used a sequential mixed-methods approach that measured change in worry and thought suppression and qualitatively explored acceptability, feasibility, and user experience with a focus group (n = 11) and in-depth interviews (n = 16). The intervention was highly acceptable, with 90% completing ≥5 sessions. Meditation and mindfulness skills led to improved sleep, greater relaxation, and more-accepting approaches to illness and illness experience. At the end of the six-week meditation course, worry, and thought suppression were significantly reduced. Positive impacts of mindfulness-based interventions on psychological health may relate to acquisition and development of meta-cognitive skills but this needs experimental confirmation. PMID:24754440

  6. Selection of reference standard during method development using the analytical hierarchy process.

    PubMed

    Sun, Wan-yang; Tong, Ling; Li, Dong-xiang; Huang, Jing-yi; Zhou, Shui-ping; Sun, Henry; Bi, Kai-shun

    2015-03-25

    Reference standard is critical for ensuring reliable and accurate method performance. One important issue is how to select the ideal one from the alternatives. Unlike the optimization of parameters, the criteria of the reference standard are always immeasurable. The aim of this paper is to recommend a quantitative approach for the selection of reference standard during method development based on the analytical hierarchy process (AHP) as a decision-making tool. Six alternative single reference standards were assessed in quantitative analysis of six phenolic acids from Salvia Miltiorrhiza and its preparations by using ultra-performance liquid chromatography. The AHP model simultaneously considered six criteria related to reference standard characteristics and method performance, containing feasibility to obtain, abundance in samples, chemical stability, accuracy, precision and robustness. The priority of each alternative was calculated using standard AHP analysis method. The results showed that protocatechuic aldehyde is the ideal reference standard, and rosmarinic acid is about 79.8% ability as the second choice. The determination results successfully verified the evaluation ability of this model. The AHP allowed us comprehensive considering the benefits and risks of the alternatives. It was an effective and practical tool for optimization of reference standards during method development. PMID:25636165

  7. Selection of reference standard during method development using the analytical hierarchy process.

    PubMed

    Sun, Wan-yang; Tong, Ling; Li, Dong-xiang; Huang, Jing-yi; Zhou, Shui-ping; Sun, Henry; Bi, Kai-shun

    2015-03-25

    Reference standard is critical for ensuring reliable and accurate method performance. One important issue is how to select the ideal one from the alternatives. Unlike the optimization of parameters, the criteria of the reference standard are always immeasurable. The aim of this paper is to recommend a quantitative approach for the selection of reference standard during method development based on the analytical hierarchy process (AHP) as a decision-making tool. Six alternative single reference standards were assessed in quantitative analysis of six phenolic acids from Salvia Miltiorrhiza and its preparations by using ultra-performance liquid chromatography. The AHP model simultaneously considered six criteria related to reference standard characteristics and method performance, containing feasibility to obtain, abundance in samples, chemical stability, accuracy, precision and robustness. The priority of each alternative was calculated using standard AHP analysis method. The results showed that protocatechuic aldehyde is the ideal reference standard, and rosmarinic acid is about 79.8% ability as the second choice. The determination results successfully verified the evaluation ability of this model. The AHP allowed us comprehensive considering the benefits and risks of the alternatives. It was an effective and practical tool for optimization of reference standards during method development.

  8. Effect of variety and processing method on functional properties of traditional sweet potato flour ("elubo") and sensory acceptability of cooked paste ("amala").

    PubMed

    Fetuga, Ganiyat; Tomlins, Keith; Henshaw, Folake; Idowu, Michael

    2014-11-01

    "Amala" is a generic term in Nigeria, used to describe a thick paste prepared by stirring flour ("elubo") from yam, cassava or unripe plantain, in hot water, to form a smooth consistency. In order to overcome its high perishability and increase the utilization of sweet potato roots, three varieties of sweet potato roots were processed into flour using two methods. The interactive effect of variety and the processing method had a significant effect (P < 0.05) on all the functional properties of the flour except yellowness, setback viscosity, and peak time. Acceptable sweet potato "amala" with average sensory acceptability score of 7.5 were obtained from yellow-fleshed varieties irrespective of the processing method. Flour that produced acceptable "amala" were characterized by lower values of protein (2.20-3.94%), fiber (1.30-1.65%), total sugar (12.41-38.83 μg/mg), water absorption capacity (168-215 g/100 g), water solubility (8.29-14.65%), swelling power (0.52-0.82 g/g), and higher peak time (6.9-8.7 min).

  9. Effect of variety and processing method on functional properties of traditional sweet potato flour ("elubo") and sensory acceptability of cooked paste ("amala").

    PubMed

    Fetuga, Ganiyat; Tomlins, Keith; Henshaw, Folake; Idowu, Michael

    2014-11-01

    "Amala" is a generic term in Nigeria, used to describe a thick paste prepared by stirring flour ("elubo") from yam, cassava or unripe plantain, in hot water, to form a smooth consistency. In order to overcome its high perishability and increase the utilization of sweet potato roots, three varieties of sweet potato roots were processed into flour using two methods. The interactive effect of variety and the processing method had a significant effect (P < 0.05) on all the functional properties of the flour except yellowness, setback viscosity, and peak time. Acceptable sweet potato "amala" with average sensory acceptability score of 7.5 were obtained from yellow-fleshed varieties irrespective of the processing method. Flour that produced acceptable "amala" were characterized by lower values of protein (2.20-3.94%), fiber (1.30-1.65%), total sugar (12.41-38.83 μg/mg), water absorption capacity (168-215 g/100 g), water solubility (8.29-14.65%), swelling power (0.52-0.82 g/g), and higher peak time (6.9-8.7 min). PMID:25493186

  10. Nozzle Initiative Industry Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    NASA Technical Reports Server (NTRS)

    Bull, William B. (Compiler); Pinoli, Pat C. (Compiler); Upton, Cindy G. (Compiler); Day, Tony (Compiler); Hill, Keith (Compiler); Stone, Frank (Compiler); Hall, William B.

    1994-01-01

    This report is a compendium of the presentations of the 12th biannual meeting of the Industry Advisory Committee under the Solid Propulsion Integrity Program. A complete transcript of the welcoming talks is provided. Presentation outlines and overheads are included for the other sessions: SPIP Overview, Past, Current and Future Activity; Test Methods Manual and Video Tape Library; Air Force Developed Computer Aided Cure Program and SPC/TQM Experience; Magneto-Optical mapper (MOM), Joint Army/NASA program to assess composite integrity; Permeability Testing; Moisture Effusion Testing by Karl Fischer Analysis; Statistical Analysis of Acceptance Test Data; NMR Phenolic Resin Advancement; Constituent Testing Highlights on the LDC Optimization Program; Carbon Sulfur Study, Performance Related Testing; Current Rayon Specifications and Future Availability; RSRM/SPC Implementation; SRM Test Methods, Delta/Titan/FBM/RSRM; and Open Forum on Performance Based Acceptance Testing -- Industry Experience.

  11. Nozzle Initiative Industry Advisory Committee on Standardization of Carbon-Phenolic Test Methods and Specifications

    NASA Astrophysics Data System (ADS)

    Bull, William B.; Pinoli, Pat C.; Upton, Cindy G.; Day, Tony; Hill, Keith; Stone, Frank; Hall, William B.

    1994-12-01

    This report is a compendium of the presentations of the 12th biannual meeting of the Industry Advisory Committee under the Solid Propulsion Integrity Program. A complete transcript of the welcoming talks is provided. Presentation outlines and overheads are included for the other sessions: SPIP Overview, Past, Current and Future Activity; Test Methods Manual and Video Tape Library; Air Force Developed Computer Aided Cure Program and SPC/TQM Experience; Magneto-Optical mapper (MOM), Joint Army/NASA program to assess composite integrity; Permeability Testing; Moisture Effusion Testing by Karl Fischer Analysis; Statistical Analysis of Acceptance Test Data; NMR Phenolic Resin Advancement; Constituent Testing Highlights on the LDC Optimization Program; Carbon Sulfur Study, Performance Related Testing; Current Rayon Specifications and Future Availability; RSRM/SPC Implementation; SRM Test Methods, Delta/Titan/FBM/RSRM; and Open Forum on Performance Based Acceptance Testing -- Industry Experience.

  12. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.243 Standard wipe sample method and size. (a) Collect a surface sample from a natural gas... June 23, 1987 and revised on April 18, 1991. This document is available on EPA's Web site at...

  13. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.243 Standard wipe sample method and size. (a) Collect a surface sample from a natural gas... June 23, 1987 and revised on April 18, 1991. This document is available on EPA's Web site at...

  14. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.243 Standard wipe sample method and size. (a) Collect a surface sample from a natural gas... June 23, 1987 and revised on April 18, 1991. This document is available on EPA's Web site at...

  15. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.243 Standard wipe sample method and size. (a) Collect a surface sample from a natural gas... June 23, 1987 and revised on April 18, 1991. This document is available on EPA's Web site at...

  16. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.243 Standard wipe sample method and size. (a) Collect a surface sample from a natural gas... June 23, 1987 and revised on April 18, 1991. This document is available on EPA's Web site at...

  17. Patient utilities in chronic musculoskeletal pain: how useful is the standard gamble method?

    PubMed

    Goossens, M E; Vlaeyen, J W; Rutten-van Mölken, M P; van der Linden, S M

    1999-03-01

    The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in which not only is the estimation of financial costs and benefits included, but so is the evaluation of costs and benefits in terms of changes in health states. The purpose of this study is to compare the psychometric qualities of two instruments for assessing patients' utilities, the rating scale (RS) and the standard gamble (SG). Such instruments are designed for their application in economic evaluation research, but have seldomly been used in chronic pain trials. Both methods provide a single measure between 0 and 1. The relationship between these utility measures and descriptive and domain-specific quality of life measures was examined in 133 fibromyalgia patients and 148 patients with chronic non-specific low back pain. Mean utility score at baseline was 0.43 with the RS and 0.78 for the SG. The correlation between both methods was found to be poor (r = 0.21). Both measures appeared to be fairly stable in a 2-week test-retest period (intra class correlation coefficient (ICC) = 0.74 and 0.77). Scores on the description of patient's own health on six domains, global assessment of change and domain specific measures correlated moderately with the RS scores and low with the SG. Multiple regression analyses demonstrated that 32% of the variance in RS values and only 13% of the variance in SG utilities could be explained by domain-specific measures. These results suggest an acceptable construct validity for the RS but insufficient construct validity for the SG. Valuations of ones own health appear only partially to be related to the assessment of the pain-specific measures and measures of distress. It can be concluded that the RS and domain-specific measures

  18. Building America Top Innovations 2014 Profile: ASHRAE Standard 62.2. Ventilation and Acceptable Indoor Air Quality in Low-Rise Residential Buildings

    SciTech Connect

    none,

    2014-11-01

    This 2014 Top Innovations profile describes Building America research and support in developing and gaining adoption of ASHRAE 62.2, a residential ventilation standard that is critical to transforming the U.S. housing industry to high-performance homes.

  19. TextTB: A Mixed Method Pilot Study Evaluating Acceptance, Feasibility, and Exploring Initial Efficacy of a Text Messaging Intervention to Support TB Treatment Adherence

    PubMed Central

    Pearce, Patricia F.; Chirico, Cristina; Etchevarria, Mirta; Cardinale, Daniel; Rubinstein, Fernando

    2013-01-01

    Objective. To assess a text messaging intervention to promote tuberculosis (TB) treatment adherence. Methods. A mixed-methods pilot study was conducted within a public pulmonary-specialized hospital in Argentina. Patients newly diagnosed with TB who were 18 or older, and had mobile phone access were recruited and randomized to usual care plus either medication calendar (n = 19) or text messaging intervention (n = 18) for the first two months of treatment. Primary outcomes were feasibility and acceptability; secondary outcomes explored initial efficacy. Results. Feasibility was evidenced by high access to mobile phones, familiarity with texting, most phones limited to basic features, a low rate of participant refusal, and many describing suboptimal TB understanding. Acceptability was evidenced by participants indicating feeling cared for, supported, responsible for their treatment, and many self-reporting adherence without a reminder. Participants in the texting group self-reported adherence on average 77% of the days whereas only 53% in calendar group returned diaries. Exploring initial efficacy, microscopy testing was low and treatment outcomes were similar in both groups. Conclusion. The texting intervention was well accepted and feasible with greater reporting of adherence using text messaging than the diary. Further evaluation of the texting intervention is warranted. PMID:24455238

  20. Combining the Best of Two Standard Setting Methods: The Ordered Item Booklet Angoff

    ERIC Educational Resources Information Center

    Smith, Russell W.; Davis-Becker, Susan L.; O'Leary, Lisa S.

    2014-01-01

    This article describes a hybrid standard setting method that combines characteristics of the Angoff (1971) and Bookmark (Mitzel, Lewis, Patz & Green, 2001) methods. The proposed approach utilizes strengths of each method while addressing weaknesses. An ordered item booklet, with items sorted based on item difficulty, is used in combination…

  1. An ecological method to understand agricultural standardization in peach orchard ecosystems

    PubMed Central

    Wan, Nian-Feng; Zhang, Ming-Yi; Jiang, Jie-Xian; Ji, Xiang-Yun; Hao-Zhang

    2016-01-01

    While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a shift. The ecological concerns stemming from the standardization of agricultural production may require new methodology. In this study, we concentrated on how ecological two-sidedness and ecological processes affect the standardization of agricultural production which was divided into three phrases (pre-, mid- and post-production), considering both the positive and negative effects of agricultural processes. We constructed evaluation indicator systems for the pre-, mid- and post-production phases and here we presented a Standardization of Green Production Index (SGPI) based on the Full Permutation Polygon Synthetic Indicator (FPPSI) method which we used to assess the superiority of three methods of standardized production for peaches. The values of SGPI for pre-, mid- and post-production were 0.121 (Level IV, “Excellent” standard), 0.379 (Level III, “Good” standard), and 0.769 × 10−2 (Level IV, “Excellent” standard), respectively. Here we aimed to explore the integrated application of ecological two-sidedness and ecological process in agricultural production. Our results are of use to decision-makers and ecologists focusing on eco-agriculture and those farmers who hope to implement standardized agricultural production practices. PMID:26899360

  2. An ecological method to understand agricultural standardization in peach orchard ecosystems.

    PubMed

    Wan, Nian-Feng; Zhang, Ming-Yi; Jiang, Jie-Xian; Ji, Xiang-Yun; Hao-Zhang

    2016-01-01

    While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a shift. The ecological concerns stemming from the standardization of agricultural production may require new methodology. In this study, we concentrated on how ecological two-sidedness and ecological processes affect the standardization of agricultural production which was divided into three phrases (pre-, mid- and post-production), considering both the positive and negative effects of agricultural processes. We constructed evaluation indicator systems for the pre-, mid- and post-production phases and here we presented a Standardization of Green Production Index (SGPI) based on the Full Permutation Polygon Synthetic Indicator (FPPSI) method which we used to assess the superiority of three methods of standardized production for peaches. The values of SGPI for pre-, mid- and post-production were 0.121 (Level IV, "Excellent" standard), 0.379 (Level III, "Good" standard), and 0.769 × 10(-2) (Level IV, "Excellent" standard), respectively. Here we aimed to explore the integrated application of ecological two-sidedness and ecological process in agricultural production. Our results are of use to decision-makers and ecologists focusing on eco-agriculture and those farmers who hope to implement standardized agricultural production practices. PMID:26899360

  3. Standard addition method for laser ablation ICPMS using a spinning platform.

    PubMed

    Claverie, Fanny; Malherbe, Julien; Bier, Naomi; Molloy, John L; Long, Stephen E

    2013-04-01

    A method has been developed for the fast and easy determination of Pb, Sr, Ba, Ni, Cu, and Zn, which are of geological and environmental interest, in solid samples by laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) using a spinning sample platform. The platform, containing a sample and a standard, is spun during the ablation, allowing the quasi-simultaneous ablation of both materials. The aerosols resulting from the ablation of sample and standard were mixed in the ablation cell allowing quantification of analytes by standard additions. The proportion of standard versus sample of the mixing can be increased by performing the ablation further from the axis of rotation. The ablated masses have been determined using a new strategy based on isotope dilution analysis. This spinning laser ablation method has been applied to the Allende meteorite and four powdered standard reference materials (SRMs) fused in lithium borate glasses: two sediments as well as a soil and a rock material. SRM 612 (Trace Elements in Glass) was also analyzed despite having a matrix slightly different from the glass standard obtained by lithium borate fusion. The deviation from the certified values was found to be less than 15% for most of the mass fractions for all the elements and samples studied, with an average precision of 10%. These results demonstrate the validity of the proposed method for the direct and fast analysis of solid samples of different matrixes by standard additions, using a single standard sample.

  4. Standard addition method for laser ablation ICPMS using a spinning platform.

    PubMed

    Claverie, Fanny; Malherbe, Julien; Bier, Naomi; Molloy, John L; Long, Stephen E

    2013-04-01

    A method has been developed for the fast and easy determination of Pb, Sr, Ba, Ni, Cu, and Zn, which are of geological and environmental interest, in solid samples by laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) using a spinning sample platform. The platform, containing a sample and a standard, is spun during the ablation, allowing the quasi-simultaneous ablation of both materials. The aerosols resulting from the ablation of sample and standard were mixed in the ablation cell allowing quantification of analytes by standard additions. The proportion of standard versus sample of the mixing can be increased by performing the ablation further from the axis of rotation. The ablated masses have been determined using a new strategy based on isotope dilution analysis. This spinning laser ablation method has been applied to the Allende meteorite and four powdered standard reference materials (SRMs) fused in lithium borate glasses: two sediments as well as a soil and a rock material. SRM 612 (Trace Elements in Glass) was also analyzed despite having a matrix slightly different from the glass standard obtained by lithium borate fusion. The deviation from the certified values was found to be less than 15% for most of the mass fractions for all the elements and samples studied, with an average precision of 10%. These results demonstrate the validity of the proposed method for the direct and fast analysis of solid samples of different matrixes by standard additions, using a single standard sample. PMID:23418996

  5. Working towards accreditation by the International Standards Organization 15189 Standard: how to validate an in-house developed method an example of lead determination in whole blood by electrothermal atomic absorption spectrometry.

    PubMed

    Garcia Hejl, Carine; Ramirez, Jose Manuel; Vest, Philippe; Chianea, Denis; Renard, Christophe

    2014-09-01

    Laboratories working towards accreditation by the International Standards Organization (ISO) 15189 standard are required to demonstrate the validity of their analytical methods. The different guidelines set by various accreditation organizations make it difficult to provide objective evidence that an in-house method is fit for the intended purpose. Besides, the required performance characteristics tests and acceptance criteria are not always detailed. The laboratory must choose the most suitable validation protocol and set the acceptance criteria. Therefore, we propose a validation protocol to evaluate the performance of an in-house method. As an example, we validated the process for the detection and quantification of lead in whole blood by electrothermal absorption spectrometry. The fundamental parameters tested were, selectivity, calibration model, precision, accuracy (and uncertainty of measurement), contamination, stability of the sample, reference interval, and analytical interference. We have developed a protocol that has been applied successfully to quantify lead in whole blood by electrothermal atomic absorption spectrometry (ETAAS). In particular, our method is selective, linear, accurate, and precise, making it suitable for use in routine diagnostics.

  6. [Preparation of sub-standard samples and XRF analytical method of powder non-metallic minerals].

    PubMed

    Kong, Qin; Chen, Lei; Wang, Ling

    2012-05-01

    In order to solve the problem that standard samples of non-metallic minerals are not satisfactory in practical work by X-ray fluorescence spectrometer (XRF) analysis with pressed powder pellet, a method was studied how to make sub-standard samples according to standard samples of non-metallic minerals and to determine how they can adapt to analysis of mineral powder samples, taking the K-feldspar ore in Ebian-Wudu, Sichuan as an example. Based on the characteristic analysis of K-feldspar ore and the standard samples by X-ray diffraction (XRD) and chemical methods, combined with the principle of the same or similar between the sub-standard samples and unknown samples, the experiment developed the method of preparation of sub-standard samples: both of the two samples above mentioned should have the same kind of minerals and the similar chemical components, adapt mineral processing, and benefit making working curve. Under the optimum experimental conditions, a method for determination of SiO2, Al2O3, Fe2O3, TiO2, CaO, MgO, K2O and Na2O of K-feldspar ore by XRF was established. Thedetermination results are in good agreement with classical chemical methods, which indicates that this method was accurate.

  7. Parallel and serial methods of calculating thermal insulation in European manikin standards.

    PubMed

    Kuklane, Kalev; Gao, Chuansi; Wang, Faming; Holmér, Ingvar

    2012-01-01

    Standard No. EN 15831:2004 provides 2 methods of calculating insulation: parallel and serial. The parallel method is similar to the global one defined in Standard No. ISO 9920:2007. Standards No. EN 342:2004, EN 14058:2004 and EN 13537:2002 refer to the methods defined in Standard No. EN ISO 15831:2004 for testing cold protective clothing or equipment. However, it is necessary to consider several issues, e.g., referring to measuring human subjects, when using the serial method. With one zone, there is no serial-parallel issue as the results are the same, while more zones increase the difference in insulation value between the methods. If insulation is evenly distributed, differences between the serial and parallel method are relatively small and proportional. However, with more insulation layers overlapping in heavy cold protective ensembles, the serial method produces higher insulation values than the parallel one and human studies. Therefore, the parallel method is recommended for standard testing.

  8. Revision of Standard Method of Test for Plane Strain Fracture Toughness

    NASA Technical Reports Server (NTRS)

    Shannon, John L., Jr.

    1998-01-01

    The purpose of this grant is to revise ASTM Standard Method of Test E-399 for Plane Strain Fracture Toughness of Metallic Materials based on users' experience, and to harmonize the Method with international standards in the interest of U. S. competitive participation in the global marketplace. Rewriting and reformatting the Method are well along. Research laboratories here and abroad have been engaged in developing technical bases for the Method's novel revision items. Close liaison is being maintained with experts in the field here and abroad to ensure consensus agreement on all substantive matters in anticipation of an eventual circulation of the document for ASTM worldwide approval.

  9. Methods for evaluating the attainment of cleanup standards. Volume 2. Ground water. Final report

    SciTech Connect

    Rogers, J.; DiGaetano, R.; Chu, A.; Bryant, E.; Lipsky, D.

    1992-07-01

    The reference document provides regional project managers, on-site coordinators, and their contractors with sampling and analysis methods for evaluating whether ground water remediation has met pre-established cleanup standards for one or more chemical contaminants at a hazardous waste site. The verification of cleanup by evaluating a site relative to a cleanup standard or an applicable or relevant and appropriate requirement (ARAR) is mandated in Section 121 of the Superfund Amendments and Reauthorization Act (SARA). The document, the second in a series, provides sampling and data analysis methods for the purpose of verifying attainment of a cleanup standard in ground water. The first volume addresses evaluating attainment in soils and solid media. Volume 2 presents statistical methods which can be used to address the uncertainty of whether a site has met a cleanup standard.

  10. Relation between the standard perturbation theory and regularized multi-point propagator method

    SciTech Connect

    Sugiyama, Naonori S.; Futamase, Toshifumi

    2013-06-01

    We investigate the relation between the regularized multi-propagator method, called 'Reg PT', and the standard perturbation theory. Reg PT is one of the most successful models to describe nonlinear evolution of dark matter fluctuations. However, Reg PT is a mathematically unproven interpolation formula between the large-scale solution calculated by the standard perturbation theory and the limiting solution in the small scale calculated by the multi-point propagator method. In this paper, we give an alternative explanation for Reg PT in the context of the standard perturbation theory, showing that Reg PT does not ever have more effective information on nonlinear matter evolution than the standard perturbation theory. In other words, the solutions of the standard perturbation theory reproduce the results of N-body simulations better than those of Reg PT, especially at the high-k region. This fact means that the standard perturbation theory at the two-loop level is still one of the best predictions of the nonlinear power spectrum to date. Nevertheless, the standard perturbation theory has not been preferred because of the divergent behavior of the solution at small scales. To solve this problem, we also propose a modified standard perturbation theory which avoids the divergence.

  11. The acceptance and feasibility of replacement feeding at 6 months as an HIV prevention method in Lilongwe, Malawi: Results from the BAN Study

    PubMed Central

    Parker, Megan E.; Bentley, Margaret E.; Chasela, Charles; Adair, Linda; Piwoz, Ellen G.; Jamieson, Denise J.; Ellington, Sascha; Kayira, Dumbani; Soko, Alice; Mkhomawanthu, Chimwemwe; Tembo, Martin; Martinson, Francis; van der Horst, Charles M.

    2011-01-01

    International guidelines recommend exclusive breastfeeding to 6 months among HIV-infected mothers choosing to breastfeed and cessation thereafter if replacement feeding is acceptable, feasible, affordable, sustainable and safe. When mothers wean they are challenged to provide an adequate replacement diet. This study investigates the use and acceptability of a lipid-based nutrient supplement (LNS) as a breastmilk substitute when provided to infants (6-12mo) of HIV-positive mothers, as part of the Breastfeeding, Antiretroviral, and Nutrition (BAN) Study. A sub-sample of mothers (n=45) participated in interviews that explored exclusive breastfeeding, weaning, and strategies to feed LNS. Mothers reported several weaning strategies, including gradual reduction of breastfeeding, expressing breastmilk into a cup, and separation of mother and child. LNS, a peanut-based micronutrient fortified paste, was highly accepted and incorporated into the traditional diet. Weaning is a feasible HIV prevention method among this population in Malawi when supported by the provision of LNS as a breastmilk substitute. PMID:21696245

  12. Incremental Validity and Informant Effect from a Multi-Method Perspective: Assessing Relations between Parental Acceptance and Children’s Behavioral Problems

    PubMed Central

    Izquierdo-Sotorrío, Eva; Holgado-Tello, Francisco P.; Carrasco, Miguel Á.

    2016-01-01

    This study examines the relationships between perceived parental acceptance and children’s behavioral problems (externalizing and internalizing) from a multi-informant perspective. Using mothers, fathers, and children as sources of information, we explore the informant effect and incremental validity. The sample was composed of 681 participants (227 children, 227 fathers, and 227 mothers). Children’s (40% boys) ages ranged from 9 to 17 years (M = 12.52, SD = 1.81). Parents and children completed both the Parental Acceptance Rejection/Control Questionnaire (PARQ/Control) and the check list of the Achenbach System of Empirically Based Assessment (ASEBA). Statistical analyses were based on the correlated uniqueness multitrait-multimethod matrix (model MTMM) by structural equations and different hierarchical regression analyses. Results showed a significant informant effect and a different incremental validity related to which combination of sources was considered. A multi-informant perspective rather than a single one increased the predictive value. Our results suggest that mother–father or child–father combinations seem to be the best way to optimize the multi-informant method in order to predict children’s behavioral problems based on perceived parental acceptance. PMID:27242582

  13. From traditional cognitive-behavioural therapy to acceptance and commitment therapy for chronic pain: a mixed-methods study of staff experiences of change.

    PubMed

    Barker, Estelle; McCracken, Lance M

    2014-08-01

    Health care organizations, both large and small, frequently undergo processes of change. In fact, if health care organizations are to improve over time, they must change; this includes pain services. The purpose of the present study was to examine a process of change in treatment model within a specialty interdisciplinary pain service in the UK. This change entailed a switch from traditional cognitive-behavioural therapy to a form of cognitive-behavioural therapy called acceptance and commitment therapy. An anonymous online survey, including qualitative and quantitative components, was carried out approximately 15 months after the initial introduction of the new treatment model and methods. Fourteen out of 16 current clinical staff responded to the survey. Three themes emerged in qualitative analyses: positive engagement in change; uncertainty and discomfort; and group cohesion versus discord. Quantitative results from closed questions showed a pattern of uncertainty about the superiority of one model over the other, combined with more positive views on progress reflected, and the experience of personal benefits, from adopting the new model. The psychological flexibility model, the model behind acceptance and commitment therapy, may clarify both processes in patient behaviour and processes of staff experience and skilful treatment delivery. This integration of processes on both sides of treatment delivery may be a strength of acceptance and commitment therapy. PMID:26516541

  14. From traditional cognitive-behavioural therapy to acceptance and commitment therapy for chronic pain: a mixed-methods study of staff experiences of change.

    PubMed

    Barker, Estelle; McCracken, Lance M

    2014-08-01

    Health care organizations, both large and small, frequently undergo processes of change. In fact, if health care organizations are to improve over time, they must change; this includes pain services. The purpose of the present study was to examine a process of change in treatment model within a specialty interdisciplinary pain service in the UK. This change entailed a switch from traditional cognitive-behavioural therapy to a form of cognitive-behavioural therapy called acceptance and commitment therapy. An anonymous online survey, including qualitative and quantitative components, was carried out approximately 15 months after the initial introduction of the new treatment model and methods. Fourteen out of 16 current clinical staff responded to the survey. Three themes emerged in qualitative analyses: positive engagement in change; uncertainty and discomfort; and group cohesion versus discord. Quantitative results from closed questions showed a pattern of uncertainty about the superiority of one model over the other, combined with more positive views on progress reflected, and the experience of personal benefits, from adopting the new model. The psychological flexibility model, the model behind acceptance and commitment therapy, may clarify both processes in patient behaviour and processes of staff experience and skilful treatment delivery. This integration of processes on both sides of treatment delivery may be a strength of acceptance and commitment therapy.

  15. An effective timing characterization method for an accuracy-proved VLSI standard cell library

    NASA Astrophysics Data System (ADS)

    Jianhua, Jiang; Man, Liang; Lei, Wang; Yumei, Zhou

    2014-02-01

    This paper presents a method of tailoring the characterization and modeling timing of a VLSI standard cell library. The paper also presents a method to validate the reasonability of the value through accuracy analysis. In the process of designing a standard cell library, this method is applied to characterize the cell library. In addition, the error calculations of some simple circuit path delays are compared between using the characterization file and an Hspice simulation. The comparison results demonstrate the accuracy of the generated timing library file.

  16. The development and standardization of testing methods for genetically modified organisms and their derived products.

    PubMed

    Zhang, Dabing; Guo, Jinchao

    2011-07-01

    As the worldwide commercialization of genetically modified organisms (GMOs) increases and consumers concern the safety of GMOs, many countries and regions are issuing labeling regulations on GMOs and their products. Analytical methods and their standardization for GM ingredients in foods and feed are essential for the implementation of labeling regulations. To date, the GMO testing methods are mainly based on the inserted DNA sequences and newly produced proteins in GMOs. This paper presents an overview of GMO testing methods as well as their standardization.

  17. Quantitative Comparison of Three Standardization Methods Using a One-Way ANOVA for Multiple Mean Comparisons

    ERIC Educational Resources Information Center

    Barrows, Russell D.

    2007-01-01

    A one-way ANOVA experiment is performed to determine whether or not the three standardization methods are statistically different in determining the concentration of the three paraffin analytes. The laboratory exercise asks students to combine the three methods in a single analytical procedure of their own design to determine the concentration of…

  18. Glossary (for Measuring and Monitoring Biological Diversity: Standard Methods for Fungi)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Approximately 300 technical terms and 250 diagrammatic sketches and illustrations are provided for the Smithsonian Institution methods book, ‘Measuring and Monitoring Biological Diversity: Standard Methods for Fungi.’ Technical terms focus on traditional morphotaxonomy, ecology, and pathology. Als...

  19. Inter-laboratory validation of standardized method to determine permeability of plastic films

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To support regulations controlling soil fumigation, we are standardizing the laboratory method we developed to measure the permeability of plastic films to fumigant vapors. The method was validated using an inter-laboratory comparison with 7 participants. Each participant evaluated the mass transfer...

  20. Addressing Next Generation Science Standards: A Method for Supporting Classroom Teachers

    ERIC Educational Resources Information Center

    Pellien, Tamara; Rothenburger, Lisa

    2014-01-01

    The Next Generation Science Standards (NGSS) will define science education for the foreseeable future, yet many educators struggle to see the bridge between current practice and future practices. The inquiry-based methods used by Extension professionals (Kress, 2006) can serve as a guide for classroom educators. Described herein is a method of…

  1. TOWARDS A STANDARD METHOD FOR THE MEASUREMENT OF ORGANIC CARBON IN SEDIMENTS

    EPA Science Inventory

    The precisions achieved by two different methods for analysis of organic carbon in soils and sediments were determined and compared. The first method is a rapid dichromate oxidation technique (Walkley-Black) that has long been a standard in soil chemistry. The second is an automa...

  2. Standard Error Estimation of 3PL IRT True Score Equating with an MCMC Method

    ERIC Educational Resources Information Center

    Liu, Yuming; Schulz, E. Matthew; Yu, Lei

    2008-01-01

    A Markov chain Monte Carlo (MCMC) method and a bootstrap method were compared in the estimation of standard errors of item response theory (IRT) true score equating. Three test form relationships were examined: parallel, tau-equivalent, and congeneric. Data were simulated based on Reading Comprehension and Vocabulary tests of the Iowa Tests of…

  3. Implementation of USP antibody standard for system suitability in capillary electrophoresis sodium dodecyl sulfate (CE-SDS) for release and stability methods.

    PubMed

    Esterman, Abbie L; Katiyar, Amit; Krishnamurthy, Girija

    2016-09-01

    Capillary electrophoresis sodium dodecyl sulfate (CE-SDS) is widely used for purity analysis of monoclonal antibody therapeutics for release and stability to demonstrate product consistency and shelf life during the manufacturing and life cycle of the product. CE-SDS method development is focused on exploring the method capability to provide the information about the product purity and product related degradants (fragmentation, aggregation etc.). In order to establish the functionality of the instrumentation, software, and sample preparation; system suitability criteria need to be defined for analytical methods using a well characterized reference standard run under the same protocol and analysis as the test articles. Typically the reference standard is produced using a manufacturing process representative of the clinical material. The qualification, control, and maintenance of in-house reference standards are established through rigorous quality and regulatory guidelines. The U.S. Pharmacopeia (USP) has developed a monoclonal IgG System Suitability Reference Standard to be utilized for assessment of system suitability in CE-SDS methods. In this communication, we evaluate the system suitability acceptance criteria performance of the USP IgG standard using two methods, the recommended USP protocol provided in monograph <129> and a molecule specific Bristol-Myers Squibb (BMS) CE-SDS method. The results from USP IgG standard were compared with two in-house monoclonal antibody reference standards. The data suggest that the USP CE-SDS method may not be suitable for CE-SDS analysis for release and stability of monoclonal antibody therapeutics due to the high level of method induced partial reduction observed for all molecules tested. This high level of fragmentation observed utilizing the USP method will result in reporting lower purity levels, which will impact the overall quality assessment of the molecule. The system suitability criteria recommended by the USP method

  4. Efficiency of alchemical free energy simulations. I. A practical comparison of the exponential formula, thermodynamic integration, and Bennett's acceptance ratio method.

    PubMed

    Bruckner, Stefan; Boresch, Stefan

    2011-05-01

    We investigate the relative efficiency of thermodynamic integration, three variants of the exponential formula, also referred to as thermodynamic perturbation, and Bennett's acceptance ratio method to compute relative and absolute solvation free energy differences. Our primary goal is the development of efficient protocols that are robust in practice. We focus on minimizing the number of unphysical intermediate states (λ-states) required for the computation of accurate and precise free energy differences. Several indicators are presented which help decide when additional λ-states are necessary. In all tests Bennett's acceptance ratio method required the least number of λ-states, closely followed by the "double-wide" variant of the exponential formula. Use of the exponential formula in only strict "forward" or "backward" mode was not found to be competitive. Similarly, the performance of thermodynamic integration in terms of efficiency was rather poor. We show that this is caused by the use of the trapezoidal rule as method of numerical quadrature. A systematic study focusing on the optimization of thermodynamic integration is presented in a companion paper.

  5. Method of Fabricating NASA-Standard Macro-Fiber Composite Piezoelectric Actuators

    NASA Technical Reports Server (NTRS)

    High, James W.; Wilkie, W. Keats

    2003-01-01

    The NASA Macro-Fiber Composite actuator is a flexible piezoelectric composite device designed for controlling vibrations and shape deformations in high performance aerospace structures. A complete method for fabricating the standard NASA Macro-Fiber Composite actuator is presented in this document. When followed precisely, these procedures will yield devices with electromechanical properties identical to the standard actuator manufactured by NASA Langley Research Center.

  6. The national education standards Quilts: a display method aiding teachers link NASA educational materials to national education standards

    NASA Technical Reports Server (NTRS)

    Knudsen, R.; Hammon, V. A.

    2002-01-01

    A matrix format developed at JPL places the national education standards in a format that can be navigated intuitively by teachers seeking to integrate NASA materials into the structure of standards based education.

  7. 42 CFR 447.205 - Public notice of changes in Statewide methods and standards for setting payment rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... methods and standards; (2) Give an estimate of any expected increase or decrease in annual aggregate expenditures; (3) Explain why the agency is changing its methods and standards; (4) Identify a local agency...

  8. Determination of acidity constants by the capillary electrophoresis internal standard method. IV. Polyprotic compounds.

    PubMed

    Cabot, Joan Marc; Fuguet, Elisabet; Ràfols, Clara; Rosés, Martí

    2013-03-01

    The IS-CE method is developed for pK(a) determination of polyprotic compounds. In this method, the internal standard (IS) and the polyprotic test compound are injected into the capillary electrophoresis (CE) system in buffers with appropriate pH. The pH of the buffers is not externally measured, but determined inside the capillary from the mobilities of the internal standards. Then the pK(a) values of the polyprotic compounds are obtained by fitting its mobilities to the in situ pH values. The method is faster than the classical CE method (a diprotic compound can be done in less than 15 min), and also than other methods like potentiometric and spectrophotometric titrations. The method has been successfully applied to 20 polyprotic test compounds of different chemical nature, including compounds with extreme or very close pK(a) values.

  9. A Web-Based Program to Increase Knowledge and Reduce Cigarette and Nargila Smoking Among Arab University Students in Israel: Mixed-Methods Study to Test Acceptability

    PubMed Central

    Linn, Shai; Rafaeli, Sheizaf

    2015-01-01

    Background Among Arab citizens in Israel, cigarette and nargila (hookah, waterpipe) smoking is a serious public health problem, particularly among the young adult population. With the dramatic increase of Internet and computer use among Arab college and university students, a Web-based program may provide an easy, accessible tool to reduce smoking rates without heavy resource demands required by traditional methods. Objective The purpose of this research was to examine the acceptability and feasibility of a pilot Web-based program that provides tailored feedback to increase smoking knowledge and reduce cigarette and nargila smoking behaviors among Arab college/university students in Israel. Methods A pilot Web-based program was developed, consisting of a self-administered questionnaire and feedback system on cigarette and nargila smoking. Arab university students were recruited to participate in a mixed-methods study, using both quantitative (pre-/posttest study design) and qualitative tools. A posttest was implemented at 1 month following participation in the intervention to assess any changes in smoking knowledge and behaviors. Focus group sessions were implemented to assess acceptability and preferences related to the Web-based program. Results A total of 225 participants—response rate of 63.2% (225/356)—completed the intervention at baseline and at 1-month poststudy, and were used for the comparative analysis. Statistically significant reductions in nargila smoking among participants (P=.001) were found. The intervention did not result in reductions in cigarette smoking. However, the tailored Web intervention resulted in statistically significant increases in the intention to quit smoking (P=.021). No statistically significant increases in knowledge were seen at 1-month poststudy. Participants expressed high satisfaction with the intervention and 93.8% (211/225) of those who completed the intervention at both time intervals reported that they would

  10. Sexual risk behaviors and acceptability of HIV pre-exposure prophylaxis among HIV-negative gay and bisexual men in serodiscordant relationships: a mixed methods study.

    PubMed

    Brooks, Ronald A; Landovitz, Raphael J; Kaplan, Rachel L; Lieber, Eli; Lee, Sung-Jae; Barkley, Thomas W

    2012-02-01

    The objective of this mixed methods study was to examine current sexual risk behaviors, acceptability and potential adoption of pre-exposure prophylaxis (PrEP) for HIV prevention, and sexual behavior intentions with PrEP adoption among HIV-negative gay and bisexual men (GBM) in HIV serodiscordant relationships. A multiracial/ethnic sample of 25 HIV-negative GBM in serodiscordant relationships completed a qualitative interview and a brief interviewer-administered survey. A modified grounded theory approach was used to identify key themes relating to acceptability and future adoption of PrEP. Participants reported engaging in sexual risk behaviors that place them at risk for HIV infection. Participants also reported a high level of acceptability for PrEP and willingness to adopt PrEP for HIV prevention. Qualitative themes explaining future PrEP adoption included: (1) the opportunity to engage in sex using a noncondom HIV prevention method, (2) protection from HIV infection, and (3) less anxiety when engaging in sex with an HIV-positive partner. Associated with the future adoption of PrEP, a majority (64%) of participants indicated the likelihood for an increase in sexual risk behaviors and a majority (60%) of participants also indicated the likelihood for a decrease or abandonment of condom use, both of which are in contrast to the findings from the large iPrEx study. These findings suggest that the use of PrEP by HIV-negative GBM in serodiscordant relationships carries with it the potential for risk compensation. The findings suggest that PrEP only be offered as part of a comprehensive HIV prevention strategy that includes ongoing risk reduction counseling in the delivery of PrEP to help moderate risk compensation.

  11. Dissolution test acceptance sampling plans.

    PubMed

    Tsong, Y; Hammerstrom, T; Lin, K; Ong, T E

    1995-07-01

    The U.S. Pharmacopeia (USP) general monograph provides a standard for dissolution compliance with the requirements as stated in the individual USP monograph for a tablet or capsule dosage form. The acceptance rules recommended by USP have important roles in the quality control process. The USP rules and their modifications are often used as an industrial lot release sampling plan, where a lot is accepted when the tablets or capsules sampled are accepted as proof of compliance with the requirement. In this paper, the operating characteristics of the USP acceptance rules are reviewed and compared to a selected modification. The operating characteristics curves show that the USP acceptance rules are sensitive to the true mean dissolution and do not reject a lot or batch that has a large percentage of tablets that dissolve with less than the dissolution specification.

  12. Development of standard test methods for unmanned and manned industrial vehicles used near humans

    NASA Astrophysics Data System (ADS)

    Bostelman, Roger; Norcross, Richard; Falco, Joe; Marvel, Jeremy

    2013-05-01

    The National Institute of Standards and Technology (NIST) has been researching human-robot-vehicle collaborative environments for automated guided vehicles (AGVs) and manned forklifts. Safety of AGVs and manned vehicles with automated functions (e.g., forklifts that slow/stop automatically in hazardous situations) are the focus of the American National Standards Institute/Industrial Truck Safety Development Foundation (ANSI/ITSDF) B56.5 safety standard. Recently, the NIST Mobile Autonomous Vehicle Obstacle Detection/Avoidance (MAVODA) Project began researching test methods to detect humans or other obstacles entering the vehicle's path. This causes potential safety hazards in manufacturing facilities where both line-of-sight and non-line-of-sight conditions are prevalent. The test methods described in this paper address both of these conditions. These methods will provide the B56.5 committee with the measurement science basis for sensing systems - both non-contact and contact - that may be used in manufacturing facilities.

  13. The ECVAM workshops: a critical assessment of their impact on the development, validation and acceptance of alternative methods.

    PubMed

    Combes, Robert D

    2002-12-01

    ECVAM initiated its workshop programme in 1994, to enable it to become well informed about the state of the art of non-animal test development and validation, and about the possible incorporation of alternatives into regulatory requirements for safety testing. Fifty-one such workshops have been held on specific topics, up to 2002. In these workshops, the current status of in vitro tests and their potential uses were reviewed and recommendations were made as to the best ways forward to progress and enhance the utilisation of in vitro methods. Reports for 46 of these workshops have been published in ATLA. Most of the workshops focused on in vitro replacement methods, although an increasing number have dealt with reduction and refinement. The recommendations in the ECVAM workshops have been progressed further by: a) the formation of ECVAM task forces; b) the organisation of further workshops; c) the activities of scientific committees; d) the provision of earmarked research funding; and e) the conduct of validation studies. Examples of each of these activities are discussed. Some individual workshops are covered in more detail and several recommendations that have so far not been acted on are also considered. The workshops and their reports have had a substantial effect on the development and implementation of alternative methods, and have been a major factor in contributing to the success of the first nine years of ECVAM's existence. It is strongly recommended that ECVAM continues to organise workshops and to publish their findings, and several suggestions are made for topics of future workshops.

  14. Primary activity standardization of (57)Co by sum-peak method.

    PubMed

    Iwahara, A; Poledna, R; da Silva, C J; Tauhata, L

    2009-10-01

    The sum-peak method was applied to standardize a (57)Co solution within the framework of an international comparison organized by International Atomic Energy Agency, in 2008, aimed toward international traceability of activity measurements. A planar germanium detector was used with the sources placed on top of the detector for activity determination measurements. An analytical expression for accidental summing correction was derived and the effect of the germanium characteristic KX-ray escape peak of 112keV was taken into account. The standard uncertainty associated to the activity concentration value was 0.37% and the result was compared with other measurement methods. PMID:19505830

  15. Data Mining Methods Applied to Flight Operations Quality Assurance Data: A Comparison to Standard Statistical Methods

    NASA Technical Reports Server (NTRS)

    Stolzer, Alan J.; Halford, Carl

    2007-01-01

    In a previous study, multiple regression techniques were applied to Flight Operations Quality Assurance-derived data to develop parsimonious model(s) for fuel consumption on the Boeing 757 airplane. The present study examined several data mining algorithms, including neural networks, on the fuel consumption problem and compared them to the multiple regression results obtained earlier. Using regression methods, parsimonious models were obtained that explained approximately 85% of the variation in fuel flow. In general data mining methods were more effective in predicting fuel consumption. Classification and Regression Tree methods reported correlation coefficients of .91 to .92, and General Linear Models and Multilayer Perceptron neural networks reported correlation coefficients of about .99. These data mining models show great promise for use in further examining large FOQA databases for operational and safety improvements.

  16. Approaches to acceptable risk

    SciTech Connect

    Whipple, C.

    1997-04-30

    Several alternative approaches to address the question {open_quotes}How safe is safe enough?{close_quotes} are reviewed and an attempt is made to apply the reasoning behind these approaches to the issue of acceptability of radiation exposures received in space. The approaches to the issue of the acceptability of technological risk described here are primarily analytical, and are drawn from examples in the management of environmental health risks. These include risk-based approaches, in which specific quantitative risk targets determine the acceptability of an activity, and cost-benefit and decision analysis, which generally focus on the estimation and evaluation of risks, benefits and costs, in a framework that balances these factors against each other. These analytical methods tend by their quantitative nature to emphasize the magnitude of risks, costs and alternatives, and to downplay other factors, especially those that are not easily expressed in quantitative terms, that affect acceptance or rejection of risk. Such other factors include the issues of risk perceptions and how and by whom risk decisions are made.

  17. A simple web-based tool to compare freshwater fish data collected using AFS standard methods

    USGS Publications Warehouse

    Bonar, Scott A.; Mercado-Silva, Norman; Rahr, Matt; Torrey, Yuta T.; Cate, Averill

    2016-01-01

    The American Fisheries Society (AFS) recently published Standard Methods for Sampling North American Freshwater Fishes. Enlisting the expertise of 284 scientists from 107 organizations throughout Canada, Mexico, and the United States, this text was developed to facilitate comparisons of fish data across regions or time. Here we describe a user-friendly web tool that automates among-sample comparisons in individual fish condition, population length-frequency distributions, and catch per unit effort (CPUE) data collected using AFS standard methods. Currently, the web tool (1) provides instantaneous summaries of almost 4,000 data sets of condition, length frequency, and CPUE of common freshwater fishes collected using standard gears in 43 states and provinces; (2) is easily appended with new standardized field data to update subsequent queries and summaries; (3) compares fish data from a particular water body with continent, ecoregion, and state data summaries; and (4) provides additional information about AFS standard fish sampling including benefits, ongoing validation studies, and opportunities to comment on specific methods. The web tool—programmed in a PHP-based Drupal framework—was supported by several AFS Sections, agencies, and universities and is freely available from the AFS website and fisheriesstandardsampling.org. With widespread use, the online tool could become an important resource for fisheries biologists.

  18. Acceptance of the bodypainting as supportive method to learn the surface locomotor apparatus anatomy of the horse.

    PubMed

    Senos, R; Ribeiro, M S; Martins, K de Souza; Pereira, L V; Mattos, M F; Kfoury Júnior, J R; Rodrigues, M R

    2015-01-01

    Although bodypainting has been reported as a great resource for teaching surface anatomy of humans, its use in veterinary anatomy has not been scientifically reported. In the present study, bodypainting was performed on 4 horses for anatomy teaching purposes of the equine locomotor apparatus. We aimed to use the bodypainting method as an additional tool to classic teaching and to test the relevance of our purpose. Twenty one Brazilian veterinary students were given a 90-min session, which included a presentation of painted horses, with opportunities for the students to ask questions and to palpate anatomic locations on the horses. Based on a questionnaire, there was unanimous student satisfaction with this technique. Furthermore, student scores on practical tests to evaluate the attention retain given immediately before and 1 h after the session were 33.9 ± 19.8% and 69.0 ± 18.4%, respectively (p < 0.001). We concluded that bodypainting has great potential for support the classic lectures of the equine locomotor apparatus.

  19. Comparison of methods for estimating Wet-Bulb Globe Temperature index from standard meteorological measurements.

    PubMed

    Patel, Tejash; Mullen, Stephen P; Santee, William R

    2013-08-01

    Environmental heat illness and injuries are a serious concern for the Army and Marines. Currently, the Wet-Bulb Globe Temperature (WBGT) index is used to evaluate heat injury risk. The index is a weighted average of dry-bulb temperature (Tdb), black globe temperature (Tbg), and natural wet-bulb temperature (Tnwb). The WBGT index would be more widely used if it could be determined using standard weather instruments. This study compares models developed by Liljegren at Argonne National Laboratory and by Matthew at the U.S. Army Institute of Environmental Medicine that calculate WBGT using standard meteorological measurements. Both models use air temperature (Ta), relative humidity, wind speed, and global solar radiation (RG) to calculate Tnwb and Tbg. The WBGT and meteorological data used for model validation were collected at Griffin, Georgia and Yuma Proving Ground (YPG), Arizona. Liljegren (YPG: R(2) = 0.709, p < 0.01; Griffin: R(2) = 0.854, p < 0.01) showed closer agreement between calculated and actual WBGT than Matthew (YPG: R(2) = 0.630, p < 0.01; Griffin: R(2) = 0.677, p < 0.01). Compared to actual WBGT heat categorization, the Matthew model tended to underpredict compared to Liljegren's classification. Results indicate Liljegren is an acceptable alternative to direct WBGT measurement, but verification under other environmental conditions is needed.

  20. Nanoscale Calibration Standards and Methods: Dimensional and Related Measurements in the Micro- and Nanometer Range

    NASA Astrophysics Data System (ADS)

    Wilkening, Günter; Koenders, Ludger

    2005-08-01

    The quantitative determination of the properties of micro- and nanostructures is essential in research and development. It is also a prerequisite in process control and quality assurance in industry. The knowledge of the geometrical dimensions of structures in most cases is the base, to which other physical and chemical properties are linked. Quantitative measurements require reliable and stable instruments, suitable measurement procedures as well as appropriate calibration artefacts and methods. The seminar "NanoScale 2004" (6th Seminar on Quantitative Microscopy and 2nd Seminar on Nanoscale Calibration Standards and Methods) at the National Metrology Institute (Physikalisch-Technische Bundesanstalt PTB), Braunschweig, Germany, continues the series of seminars on Quantitative Microscopy. The series stimulates the exchange of information between manufacturers of relevant hard- and software and the users in science and industry. Topics addressed in these proceedings are a) the application of quantitative measurements and measurement problems in: microelectronics, microsystems technology, nano/quantum/molecular electronics, chemistry, biology, medicine, environmental technology, materials science, surface processing b) calibration & correction methods: calibration methods, calibration standards, calibration procedures, traceable measurements, standardization, uncertainty of measurements c) instrumentation and methods: novel/improved instruments and methods, reproducible probe/sample positioning, position-measuring systems, novel/improved probe/detector systems, linearization methods, image processing

  1. A Stable Whole Building Performance Method for Standard 90.1

    SciTech Connect

    Rosenberg, Michael I.; Eley, Charles

    2013-05-01

    Wouldn’t it be great if a single energy model could be used to demonstrate minimum code compliance, green code compliance, establish a Leadership in Energy and Environmental Design (LEED) rating, and determine eligibility for federal tax and utility incentives? Even better, what if the basic rules for creating those models did not change every few years? This paper descibes a recently proposed addendum to ASHRAE/ANSI/IES Standard 90.1 aims to meet those goals. Addendum BM establishes the Performance Rating Method found in Appendix G of Standard 90.1 as a new method of compliance while maintaining its traditional use in gauging the efficiency of beyond code buildings. Furthermore, Addendum BM sets a common baseline building that does not change with each update to the standard.

  2. Towards standard methods for the detection of Cryptosporidium parvum on lettuce and raspberries. Part 1: development and optimization of methods.

    PubMed

    Cook, N; Paton, C A; Wilkinson, N; Nichols, R A B; Barker, K; Smith, H V

    2006-06-15

    No standard method is available for detecting protozoan parasites on foods such as soft fruit and salad vegetables. We report on optimizing methods for detecting Cryptosporidium parvum on lettuce and raspberries. These methods are based on four basic stages: extraction of oocysts from the foodstuffs, concentration of the extract and separation of the oocysts from food materials, staining of the oocysts to allow their visualization, and identification of oocysts by microscopy. The concentration and separation steps are performed by centrifugation, followed by immunomagnetic separation using proprietary kits. Oocyst staining is also performed using proprietary reagents. The performance parameters of the extraction steps were extensively optimized, using artificially contaminated samples. The fully developed methods were tested several times to determine their reliability. The method to detect C. parvum on lettuce recovered 59.0+/-12.0% (n=30) of artificially contaminated oocysts. The method to detect C. parvum on raspberries recovered 41.0+/-13.0% (n=30) of artificially contaminated oocysts. PMID:16529835

  3. Assessment of Respondent Acceptability for Preference Measures in Stuttering

    ERIC Educational Resources Information Center

    Franic, Duska M.; Bothe, Anne K.; Bramlett, Robin E.

    2012-01-01

    Purpose: To assess the feasibility of using one or more of four standard economic preference measures to assess health-related quality of life in stuttering, by assessing respondents' views of the acceptability of those measures. Method and results: A graphic positioning scale approach was used with 80 adults to assess four variables previously…

  4. Commentary: A Response to Reckase's Conceptual Framework and Examples for Evaluating Standard Setting Methods

    ERIC Educational Resources Information Center

    Schulz, E. Matthew

    2006-01-01

    A look at real data shows that Reckase's psychometric theory for standard setting is not applicable to bookmark and that his simulations cannot explain actual differences between methods. It is suggested that exclusively test-centered, criterion-referenced approaches are too idealized and that a psychophysics paradigm and a theory of group…

  5. Instructional Basics: Oppelt Standard Method of Therapeutic and Recreational Ice Skating.

    ERIC Educational Resources Information Center

    Oppelt, Kurt

    Detailed in the booklet is the standard ice skating method and considered are the benefits of therapeutic ice skating for the handicapped and aged. Values for the mentally retarded and physically handicapped are seen to include physiological (such as increased flexibility and improved posture), psychological (including satifaction and enhanced…

  6. On the reliability of Fusarium oxysporum f. sp. niveum research: Do we need standardized testing methods?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fusarium oxysporum f. sp. nivium (Fon) is a pathogen highly variable in aggressiveness that requires a standardized testing method to more accurately define isolate aggressiveness (races) and to identify resistant watermelon lines. Isolates of Fon vary in aggressiveness from weakly to highly aggres...

  7. 40 CFR 1043.50 - Approval of methods to meet Tier 1 retrofit NOX standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... retrofit NOX standards. 1043.50 Section 1043.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF NOX, SOX, AND PM EMISSIONS FROM MARINE ENGINES AND VESSELS SUBJECT TO THE MARPOL PROTOCOL § 1043.50 Approval of methods to meet Tier 1 retrofit NOX...

  8. 40 CFR 1043.50 - Approval of methods to meet Tier 1 retrofit NOX standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... retrofit NOX standards. 1043.50 Section 1043.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF NOX, SOX, AND PM EMISSIONS FROM MARINE ENGINES AND VESSELS SUBJECT TO THE MARPOL PROTOCOL § 1043.50 Approval of methods to meet Tier 1 retrofit NOX...

  9. 40 CFR 1043.50 - Approval of methods to meet Tier 1 retrofit NOX standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... retrofit NOX standards. 1043.50 Section 1043.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF NOX, SOX, AND PM EMISSIONS FROM MARINE ENGINES AND VESSELS SUBJECT TO THE MARPOL PROTOCOL § 1043.50 Approval of methods to meet Tier 1 retrofit NOX...

  10. 40 CFR 1043.50 - Approval of methods to meet Tier 1 retrofit NOX standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... retrofit NOX standards. 1043.50 Section 1043.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF NOX, SOX, AND PM EMISSIONS FROM MARINE ENGINES AND VESSELS SUBJECT TO THE MARPOL PROTOCOL § 1043.50 Approval of methods to meet Tier 1 retrofit NOX...

  11. 40 CFR 1043.50 - Approval of methods to meet Tier 1 retrofit NOX standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... retrofit NOX standards. 1043.50 Section 1043.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF NOX, SOX, AND PM EMISSIONS FROM MARINE ENGINES AND VESSELS SUBJECT TO THE MARPOL PROTOCOL § 1043.50 Approval of methods to meet Tier 1 retrofit NOX...

  12. Building America Guidance for Identifying and Overcoming Code, Standard, and Rating Method Barriers

    SciTech Connect

    Cole, P. C.; Halverson, M. A.

    2013-09-01

    This guidance document was prepared using the input from the meeting summarized in the draft CSI Roadmap to provide Building America research teams and partners with specific information and approaches to identifying and overcoming potential barriers to Building America innovations arising in and/or stemming from codes, standards, and rating methods.

  13. 40 CFR 98.7 - What standardized methods are incorporated by reference into this part?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... reference were approved by the Director of Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR... approved for § 98.244(b)(4)(xi). (49) ASTM D7633-10 Standard Test Method for Carbon Black—Carbon Content....org. (1) CO2 Emissions Calculation Protocol for the Lime Industry—English Units Version, February...

  14. 40 CFR 98.7 - What standardized methods are incorporated by reference into this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... U.S.C. 552(a) and 1 CFR part 51. These materials are incorporated as they exist on the date of..., 2009, IBR approved for § 98.244(b)(4)(xi). (49) ASTM D7633-10 Standard Test Method for Carbon Black..., http://www.lime.org. (1) CO2 Emissions Calculation Protocol for the Lime Industry—English Units...

  15. 40 CFR 98.7 - What standardized methods are incorporated by reference into this part?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... reference were approved by the Director of Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR...-10 Standard Test Method for Carbon Black—Carbon Content, approved May 15, 2010, IBR approved for § 98... Protocol for the Lime Industry—English Units Version, February 5, 2008 Revision—National Lime...

  16. 40 CFR 98.7 - What standardized methods are incorporated by reference into this part?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... reference were approved by the Director of Federal Register in accordance with 5 U.S.C. 552(a) and 1 CFR...-10 Standard Test Method for Carbon Black—Carbon Content, approved May 15, 2010, IBR approved for § 98... Protocol for the Lime Industry—English Units Version, February 5, 2008 Revision—National Lime...

  17. Standard Errors of the Kernel Equating Methods under the Common-Item Design.

    ERIC Educational Resources Information Center

    Liou, Michelle; And Others

    This research derives simplified formulas for computing the standard error of the frequency estimation method for equating score distributions that are continuized using a uniform or Gaussian kernel function (P. W. Holland, B. F. King, and D. T. Thayer, 1989; Holland and Thayer, 1987). The simplified formulas are applicable to equating both the…

  18. A uniform nonlinearity criterion for rational functions applied to calibration curve and standard addition methods.

    PubMed

    Michałowska-Kaczmarczyk, Anna Maria; Asuero, Agustin G; Martin, Julia; Alonso, Esteban; Jurado, Jose Marcos; Michałowski, Tadeusz

    2014-12-01

    Rational functions of the Padé type are used for the calibration curve (CCM), and standard addition (SAM) methods purposes. In this paper, the related functions were applied to results obtained from the analyses of (a) nickel with use of FAAS method, (b) potassium according to FAES method, and (c) salicylic acid according to HPLC-MS/MS method. A uniform, integral criterion of nonlinearity of the curves, obtained according to CCM and SAM, is suggested. This uniformity is based on normalization of the approximating functions within the frames of a unit area.

  19. Device and methods for "gold standard" registration of clinical 3D and 2D cerebral angiograms

    NASA Astrophysics Data System (ADS)

    Madan, Hennadii; Likar, Boštjan; Pernuš, Franjo; Å piclin, Žiga

    2015-03-01

    Translation of any novel and existing 3D-2D image registration methods into clinical image-guidance systems is limited due to lack of their objective validation on clinical image datasets. The main reason is that, besides the calibration of the 2D imaging system, a reference or "gold standard" registration is very difficult to obtain on clinical image datasets. In the context of cerebral endovascular image-guided interventions (EIGIs), we present a calibration device in the form of a headband with integrated fiducial markers and, secondly, propose an automated pipeline comprising 3D and 2D image processing, analysis and annotation steps, the result of which is a retrospective calibration of the 2D imaging system and an optimal, i.e., "gold standard" registration of 3D and 2D images. The device and methods were used to create the "gold standard" on 15 datasets of 3D and 2D cerebral angiograms, whereas each dataset was acquired on a patient undergoing EIGI for either aneurysm coiling or embolization of arteriovenous malformation. The use of the device integrated seamlessly in the clinical workflow of EIGI. While the automated pipeline eliminated all manual input or interactive image processing, analysis or annotation. In this way, the time to obtain the "gold standard" was reduced from 30 to less than one minute and the "gold standard" of 3D-2D registration on all 15 datasets of cerebral angiograms was obtained with a sub-0.1 mm accuracy.

  20. A comparison of methods for determining lead content in drinking water: a portable anodic stripping voltammetry instrument method versus the standard EPA 239.2 method.

    PubMed

    Savely, S M; Emery, R J; Connor, T H

    2000-01-01

    Lead levels in drinking water were measured by the standard U.S. Environmental Protection Agency (EPA)-approved atomic absorption spectroscopy-graphite furnace Method 239.2 and compared with determinations made with a newly available portable anodic stripping voltammetry (PASV) instrument. A standard curve was prepared at 2, 5, 10, 15, 20, 25, and 30 microg/L of lead. PASV instrument readings were lower than standard EPA method values, with a mean difference and standard error (SE) of the mean between the two of 1.538+/-0.588 microg/L (n = 7, p = 0.040, significant at the 95% confidence interval [CI]). First-flush drinking water samples collected from 144 water fountains/coolers were preserved with nitric acid. Total lead content was tested twice for 29 EPA method samples and 54 PASV instrument samples to determine the variation within each method; results were not significant at the 95% CI. Total lead content was determined for 144 samples by both methods. PASV instrument readings were lower than standard EPA method values (mean difference and SE of the mean 0.630+/-0.206 microg/L; n = 144, p = 0.0027, significant at the 95% CI). Mean and standard deviation of the 144 samples for the EPA method and the PASV instrument were 6.5+/-11.8 microg/L and 5.9+/-11.6 microg/L, respectively. Means were below the action level for lead of 15 ppb (microg/L), but some values were above the action level (18 [13%] using the EPA method; 20 [14%] using the PASV instrument). Retesting by EPA method showed two false positive PASV values. Results indicate that in some field situations the PASV instrument may prove useful due to its relatively low price, small size, ease of use, and quick readings.

  1. A Comparison of Three Methods for Computing Scale Score Conditional Standard Errors of Measurement. ACT Research Report Series, 2013 (7)

    ERIC Educational Resources Information Center

    Woodruff, David; Traynor, Anne; Cui, Zhongmin; Fang, Yu

    2013-01-01

    Professional standards for educational testing recommend that both the overall standard error of measurement and the conditional standard error of measurement (CSEM) be computed on the score scale used to report scores to examinees. Several methods have been developed to compute scale score CSEMs. This paper compares three methods, based on…

  2. Recommendations and best practices for reference standards and reagents used in bioanalytical method validation.

    PubMed

    Bower, Joseph F; McClung, Jennifer B; Watson, Carl; Osumi, Takahiko; Pastre, Kátia

    2014-03-01

    The continued globalization of pharmaceutics has increased the demand for companies to know and understand the regulations that exist across the globe. One hurdle facing pharmaceutical and biotechnology companies developing new drug candidates is interpreting the current regulatory guidance documents and industry publications associated with bioanalytical method validation (BMV) from each of the different agencies throughout the world. The objective of this commentary is to provide our opinions on the best practices for reference standards and key reagents, such as metabolites and internal standards used in the support of regulated bioanalysis based on a review of current regulatory guidance documents and industry white papers for BMV.

  3. Proceedings of the Advisory Committee on standardization of carbon-phenolic test methods and specifications

    NASA Technical Reports Server (NTRS)

    Hall, William B.

    1991-01-01

    Proceedings of the Advisory Committee on Standardization of carbon-phenolic test methods and specifications are compiled. The following subject areas are covered: ashing procedures and alkali metal content of carbon fiber and fabrics; SPIP product identification code; SPIP initiative to adopt a water-soluble rayon yarn lubricant/size for weaving; fabric oxidation mass loss test; shelf life limit for prepregs, industry standard; silicon contamination update; resin, filler, and fabric content in prepreg; carbon assay testing calibration; thiokol rayon specifications; and SPIP low conductivity PAN program.

  4. Measurement methods and standards for processing and application of thermal barrier coatings

    NASA Technical Reports Server (NTRS)

    Dapkunas, S. J.

    1995-01-01

    Application of thermal barrier coatings deposited by thermal spray, physical vapor and possibly other methods is expected to be extended from aircraft gas turbines to industrial and utility gas turbines as well as diesel engines. This increased usage implies the participation of greater numbers of processors and users, making the availability of standards for process control and property measurement more important. Available standards for processing and evaluation of thermal barrier coatings are identified as well as those needed in the future but currently unavailable.

  5. Evaluation of mechanical properties of structural materials at cryogenic temperatures and international standardization for those methods

    NASA Astrophysics Data System (ADS)

    Ogata, T.

    2014-01-01

    Testing methods for mechanical properties of structural materials at cryogenic temperatures had been developed rapidly after 1980, however, until 1985 many researches on cryogenic structural materials have been reported using their own methods and new materials have been developed for ITER. Since 1986, a series of international inter-laboratory comparisons on the evaluation of mechanical properties of cryogenic structural materials have been performed among the participants of US-Japan cooperation project and VAMAS (the Versailles Project on Advanced Materials and Standards) in order to establish unified test methods. Through these international collaborations and Round-Robin Tests, we have accumulated knowledge about mechanical tests at 4 K, and have prepared a draft of an international standard for tensile testing in liquid helium. After testing conditions, strain measurements and other technical points have been discussed, those drafts were submitted to ISO. The outline, development, and discussion of the documents so far, with the results of RRTs, were discussed.

  6. Standard addition method for free acid determination in solutions with hydrolyzable ions

    SciTech Connect

    Baumann, E.W.

    1981-01-01

    The free acid content of solutions containing hydrolyzable ions has been determined potentiometrically by a standard addition method. Two increments of acid are added to the sample in a 1M potassium thiocyanate solution. The sample concentration is calculated by solution of three simultaneous Nernst equations. The method has been demonstrated for solutions containing Al/sup 3 +/, Cr/sup 3 +/, Fe/sup 3 +/, Ni/sup 2 +/, Th/sup 4 +/, or UO/sub 2//sup 2 +/ with a metal-to-acid ratio of < 2.5. The method is suitable for determination of 10 ..mu..moles acid in 10 mL total volume. The accuracy is verifiable by reasonable agreement of the Nerst slopes found in the presence and absence of hydrolyzable ions. The relative standard deviation is < 2.5 percent.

  7. Laboratory Evaluation of Air Flow Measurement Methods for Residential HVAC Returns for New Instrument Standards

    SciTech Connect

    Walker, Iain; Stratton, Chris

    2015-08-01

    This project improved the accuracy of air flow measurements used in commissioning California heating and air conditioning systems in Title 24 (Building and Appliance Efficiency Standards), thereby improving system performance and efficiency of California residences. The research team at Lawrence Berkeley National Laboratory addressed the issue that typical tools used by contractors in the field to test air flows may not be accurate enough to measure return flows used in Title 24 applications. The team developed guidance on performance of current diagnostics as well as a draft test method for use in future evaluations. The study team prepared a draft test method through ASTM International to determine the uncertainty of air flow measurements at residential heating ventilation and air conditioning returns and other terminals. This test method, when finalized, can be used by the Energy Commission and other entities to specify required accuracy of measurement devices used to show compliance with standards.

  8. Methods for assessing the quality of mammalian embryos: How far we are from the gold standard?

    PubMed

    Rocha, José C; Passalia, Felipe; Matos, Felipe D; Maserati, Marc P; Alves, Mayra F; Almeida, Tamie G de; Cardoso, Bruna L; Basso, Andrea C; Nogueira, Marcelo F G

    2016-01-01

    Morphological embryo classification is of great importance for many laboratory techniques, from basic research to the ones applied to assisted reproductive technology. However, the standard classification method for both human and cattle embryos, is based on quality parameters that reflect the overall morphological quality of the embryo in cattle, or the quality of the individual embryonic structures, more relevant in human embryo classification. This assessment method is biased by the subjectivity of the evaluator and even though several guidelines exist to standardize the classification, it is not a method capable of giving reliable and trustworthy results. Latest approaches for the improvement of quality assessment include the use of data from cellular metabolism, a new morphological grading system, development kinetics and cleavage symmetry, embryo cell biopsy followed by pre-implantation genetic diagnosis, zona pellucida birefringence, ion release by the embryo cells and so forth. Nowadays there exists a great need for evaluation methods that are practical and non-invasive while being accurate and objective. A method along these lines would be of great importance to embryo evaluation by embryologists, clinicians and other professionals who work with assisted reproductive technology. Several techniques shows promising results in this sense, one being the use of digital images of the embryo as basis for features extraction and classification by means of artificial intelligence techniques (as genetic algorithms and artificial neural networks). This process has the potential to become an accurate and objective standard for embryo quality assessment. PMID:27584609

  9. Methods for assessing the quality of mammalian embryos: How far we are from the gold standard?

    PubMed

    Rocha, José C; Passalia, Felipe; Matos, Felipe D; Maserati, Marc P; Alves, Mayra F; Almeida, Tamie G de; Cardoso, Bruna L; Basso, Andrea C; Nogueira, Marcelo F G

    2016-08-01

    Morphological embryo classification is of great importance for many laboratory techniques, from basic research to the ones applied to assisted reproductive technology. However, the standard classification method for both human and cattle embryos, is based on quality parameters that reflect the overall morphological quality of the embryo in cattle, or the quality of the individual embryonic structures, more relevant in human embryo classification. This assessment method is biased by the subjectivity of the evaluator and even though several guidelines exist to standardize the classification, it is not a method capable of giving reliable and trustworthy results. Latest approaches for the improvement of quality assessment include the use of data from cellular metabolism, a new morphological grading system, development kinetics and cleavage symmetry, embryo cell biopsy followed by pre-implantation genetic diagnosis, zona pellucida birefringence, ion release by the embryo cells and so forth. Nowadays there exists a great need for evaluation methods that are practical and non-invasive while being accurate and objective. A method along these lines would be of great importance to embryo evaluation by embryologists, clinicians and other professionals who work with assisted reproductive technology. Several techniques shows promising results in this sense, one being the use of digital images of the embryo as basis for features extraction and classification by means of artificial intelligence techniques (as genetic algorithms and artificial neural networks). This process has the potential to become an accurate and objective standard for embryo quality assessment.

  10. Standard Extraction Methods May Underestimate Nitrate Stocks Captured by Field-Aged Biochar.

    PubMed

    Haider, Ghulam; Steffens, Diedrich; Müller, Christoph; Kammann, Claudia I

    2016-07-01

    Biochar (BC) has been shown to increase the potential for N retention in agricultural soils. However, the form of N retained and its strength of retention are poorly understood. Here, we examined if the N retained could be readily extractable by standard methods and if the amount of N retained varied with BC field ageing. We investigated soil and field-aged BC (BC) particles of a field experiment (sandy soil amended with BC at 0, 15, and 30 t ha) under two watering regimes (irrigated and rain-fed). Throughout the study, greater nitrate than ammonium retention was observed with BC addition in topsoil (0-15 cm). Subsoil (15-30 cm) nitrate concentrations were reduced in BC treatments, indicating reduced nitrate leaching (standard 2 mol L KCl method). The mineral-N release of picked BC particles was examined with different methods: standard 2 mol L KCl extraction; repeated (10×) extraction in 2 mol L KCl at 22 ± 2°C and 80°C (M); electro-ultrafiltration (M); repeated water + KCl long-term shaking (M); and M plus one repeated shaking at 80°C (M). Nitrate amounts captured by BC particles were several-fold greater than those in the BC-amended soil. Compared with M, standard 2 mol L KCl or electro-ultrafiltration extractions retrieved only 13 and 30% of the total extractable nitrates, respectively. Our results suggest that "nitrate capture" by BC may reduce nitrate leaching in the field and that the inefficiency of standard extraction methods deserves closer research attention to decipher mechanisms for reactive N management. PMID:27380067

  11. A new method to compute standard-weight equations that reduces length-related bias

    USGS Publications Warehouse

    Gerow, K.G.; Anderson-Sprecher, R. C.; Hubert, W.A.

    2005-01-01

    We propose a new method for developing standard-weight (Ws) equations for use in the computation of relative weight (Wr) because the regression line-percentile (RLP) method often leads to length-related biases in Ws equations. We studied the structural properties of W s equations developed by the RLP method through simulations, identified reasons for biases, and compared Ws equations computed by the RLP method and the new method. The new method is similar to the RLP method but is based on means of measured weights rather than on means of weights predicted from regression models. The new method also models curvilinear W s relationships not accounted for by the RLP method. For some length-classes in some species, the relative weights computed from Ws equations developed by the new method were more than 20 Wr units different from those using Ws equations developed by the RLP method. We recommend assessment of published Ws equations developed by the RLP method for length-related bias and use of the new method for computing new Ws equations when bias is identified. ?? Copyright by the American Fisheries Society 2005.

  12. Building America Guidance for Identifying and Overcoming Code, Standard, and Rating Method Barriers

    SciTech Connect

    Cole, Pamala C.; Halverson, Mark A.

    2013-09-01

    The U.S. Department of Energy’s (DOE) Building America program implemented a new Codes and Standards Innovation (CSI) Team in 2013. The Team’s mission is to assist Building America (BA) research teams and partners in identifying and resolving conflicts between Building America innovations and the various codes and standards that govern the construction of residences. A CSI Roadmap was completed in September, 2013. This guidance document was prepared using the information in the CSI Roadmap to provide BA research teams and partners with specific information and approaches to identifying and overcoming potential barriers to Building America (BA) innovations arising in and/or stemming from codes, standards, and rating methods. For more information on the BA CSI team, please email: CSITeam@pnnl.gov

  13. Trace iodine quantitation in biological samples by mass spectrometric methods: the optimum internal standard.

    PubMed

    Dyke, Jason V; Dasgupta, Purnendu K; Kirk, Andrea B

    2009-07-15

    Accurate quantitation of iodine in biological samples is essential for studies of nutrition and medicine, as well as for epidemiological studies for monitoring intake of this essential nutrient. Despite the importance of accurate measurement, a standardized method for iodine analysis of biological samples is yet to be established. We have evaluated the effectiveness of (72)Ge, (115)In, and (129)I as internal standards for measurement of iodine in milk and urine samples by induction coupled plasma mass spectrometry (ICP-MS) and of (35)Cl(18)O(4)(-), (129)I(-), and 2-chlorobenzenesulfonate (2-CBS) as internal standards for ion chromatography-tandem mass spectrometry (IC-MS/MS). We found recovery of iodine to be markedly low when IC-MS/MS was used without an internal standard. Percent recovery was similarly low using (35)Cl(18)O(4) as an internal standard for milk and unpredictable when used for urine. 2-Chlorobenzebenzenesulfonate provided accurate recovery of iodine from milk, but overestimated iodine in urine samples by as much as a factor of 2. Percent recovery of iodine from milk and urine using ICP-MS without an internal standard was approximately 120%. Use of (115)In predicted approximately 60% of known values for both milk and urine samples. (72)Ge provided reasonable and consistent percent recovery for iodine in milk samples (approximately 108%) but resulted in approximately 80% recovery of iodine from urine. Use of (129)I as an internal standard resulted in excellent recovery of iodine from both milk and urine samples using either IC-MS/MS and ICP-MS.

  14. Performance standard-based validation study for local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method.

    PubMed

    Ahn, Ilyoung; Kim, Tae-Sung; Jung, Eun-Sun; Yi, Jung-Sun; Jang, Won-Hee; Jung, Kyoung-Mi; Park, Miyoung; Jung, Mi-Sook; Jeon, Eun-Young; Yeo, Kyeong-Uk; Jo, Ji-Hoon; Park, Jung-Eun; Kim, Chang-Yul; Park, Yeong-Chul; Seong, Won-Keun; Lee, Ai-Young; Chun, Young Jin; Jeong, Tae Cheon; Jeung, Eui Bae; Lim, Kyung-Min; Bae, SeungJin; Sohn, Soojung; Heo, Yong

    2016-10-01

    Local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method (LLNA: BrdU-FCM) is a modified non-radioisotopic technique with the additional advantages of accommodating multiple endpoints with the introduction of FCM, and refinement and reduction of animal use by using a sophisticated prescreening scheme. Reliability and accuracy of the LLNA: BrdU-FCM was determined according to OECD Test Guideline (TG) No. 429 (Skin Sensitization: Local Lymph Node Assay) performance standards (PS), with the participation of four laboratories. Transferability was demonstrated through successfully producing stimulation index (SI) values for 25% hexyl cinnamic aldehyde (HCA) consistently greater than 3, a predetermined threshold, by all participating laboratories. Within- and between-laboratory reproducibility was shown using HCA and 2,4-dinitrochlorobenzene, in which EC2.7 values (the estimated concentrations eliciting an SI of 2.7, the threshold for LLNA: BrdU-FCM) fell consistently within the acceptance ranges, 0.025-0.1% and 5-20%, respectively. Predictive capacity was tested using the final protocol version 1.3 for the 18 reference chemicals listed in OECD TG 429, of which results showed 84.6% sensitivity, 100% specificity, and 88.9% accuracy compared with the original LLNA. The data presented are considered to meet the performance criteria for the PS, and its predictive capacity was also sufficiently validated. PMID:27318101

  15. Paediatric Rehabilitation Treatment Standards: A Method for Quality Assurance in Germany

    PubMed Central

    Ahnert, Jutta; Löffler, Stefan; Müller, Jochen; Lukasczik, Matthias; Brüggemann, Silke; Vogel, Heiner

    2014-01-01

    Over the last few years, the German Pension Insurance has implemented a new method of quality assurance for inpatient rehabilitation of children and adolescents diagnosed with bronchial asthma, obesity, or atopic dermatitis: the so-called rehabilitation treatment standards (RTS). They aim at promoting a comprehensive and evidence-based care in rehabilitation. Furthermore, they are intended to make the therapeutic processes in medical rehabilitation as well as potential deficits more transparent. The development of RTS was composed of five phases during which current scientific evidence, expert knowledge, and patient expectations were included. Their core element is the specification of evidence-based treatment modules that describe a good rehabilitation standard for children diagnosed with bronchial asthma, obesity, or atopic dermatitis. Opportunities and limitations of the RTS as a tool for quality assurance are discussed. Significance for public health The German pension insurance’s rehabilitation treatment standards (RTS) for inpatient rehabilitation of children and adolescents aim at contributing to a comprehensive and evidence-based care in paediatric rehabilitation. As a core element, they comprise evidence-based treatment modules that describe a good rehabilitation standard for children diagnosed with bronchial asthma, obesity, or atopic dermatitis. Although the RTS have been developed for the specific context of the German health care system, they may be referred to as a more general starting point regarding the development of health care and quality assurance standards in child/adolescent medical rehabilitative care. PMID:25343137

  16. Standardization of a method for the detection of helminth eggs and larvae in lettuce.

    PubMed

    Matosinhos, F C; Valenzuela, V C; Silveira, J A; Rabelo, E M

    2016-05-01

    Despite reports that food-borne parasitic infections have been increasing worldwide, the methodologies employed to detect food contamination by helminths are still largely based on methodologies used to detect these pathogens in feces and water. This study sought to improve the diagnosis of parasitic contaminants in lettuce by standardizing a method for detecting helminth eggs and larvae and estimating their percentage of recovery. Sanitized lettuces were artificially contaminated with different amounts of Ascaris suum and hookworm eggs and larvae. To standardize the method, we tested liquid extractors, vegetable washing steps, and spontaneous sedimentation times. Higher percentages of egg and larvae recovery were obtained using 1 M glycine as the liquid extractor, manual shaking for 3 min and 2 h of sedimentation. Five different levels of artificial contamination (ten replicates each; n = 50) were tested using these standardized conditions, yielding an average recovery of 62.6 % (±20.2), 51.9 % (±20.0), and 50.0 % (±27.3) for A. suum eggs, hookworm eggs, and larvae, respectively. Tests were performed with a different matrix to evaluate the performance of the method. Furthermore, collaborative analytical studies performed by different laboratories produced satisfactory results. The method for the identification of helminth eggs and larvae proposed in this study proved to be simpler and more efficient than previously published procedures, thereby demonstrating its potential contribution to health surveillance and epidemiological studies. PMID:26786833

  17. Acceptance of Commercially Available Wearable Activity Trackers Among Adults Aged Over 50 and With Chronic Illness: A Mixed-Methods Evaluation

    PubMed Central

    Mercer, Kathryn; Giangregorio, Lora; Schneider, Eric; Chilana, Parmit; Li, Melissa

    2016-01-01

    Background Physical inactivity and sedentary behavior increase the risk of chronic illness and death. The newest generation of “wearable” activity trackers offers potential as a multifaceted intervention to help people become more active. Objective To examine the usability and usefulness of wearable activity trackers for older adults living with chronic illness. Methods We recruited a purposive sample of 32 participants over the age of 50, who had been previously diagnosed with a chronic illness, including vascular disease, diabetes, arthritis, and osteoporosis. Participants were between 52 and 84 years of age (mean 64); among the study participants, 23 (72%) were women and the mean body mass index was 31 kg/m2. Participants tested 5 trackers, including a simple pedometer (Sportline or Mio) followed by 4 wearable activity trackers (Fitbit Zip, Misfit Shine, Jawbone Up 24, and Withings Pulse) in random order. Selected devices represented the range of wearable products and features available on the Canadian market in 2014. Participants wore each device for at least 3 days and evaluated it using a questionnaire developed from the Technology Acceptance Model. We used focus groups to explore participant experiences and a thematic analysis approach to data collection and analysis. Results Our study resulted in 4 themes: (1) adoption within a comfort zone; (2) self-awareness and goal setting; (3) purposes of data tracking; and (4) future of wearable activity trackers as health care devices. Prior to enrolling, few participants were aware of wearable activity trackers. Most also had been asked by a physician to exercise more and cited this as a motivation for testing the devices. None of the participants planned to purchase the simple pedometer after the study, citing poor accuracy and data loss, whereas 73% (N=32) planned to purchase a wearable activity tracker. Preferences varied but 50% felt they would buy a Fitbit and 42% felt they would buy a Misfit, Jawbone, or

  18. A method for the geometric and densitometric standardization of intraoral radiographs

    SciTech Connect

    Duckworth, J.E.; Judy, P.F.; Goodson, J.M.; Socransky, S.S.

    1983-07-01

    The interpretation of dental radiographs for the diagnosis of periodontal disease conditions poses several difficulties. These include the inability to adequately reproduce the projection geometry and optical density of the exposures. In order to improve the ability to extract accurate quantitative information from a radiographic survey of periodontal status, a method was developed which provided for consistent reproduction of both geometric and densitometric exposure parameters. This technique employed vertical bitewing projections in holders customized to individual segments of the dentition. A copper stepwedge was designed to provide densitometric standardization, and wire markers were included to permit measurement of angular variation. In a series of 53 paired radiographs, measurement of alveolar crest heights was found to be reproducible within approximately 0.1 mm. This method provided a full mouth radiographic survey using seven films, each complete with internal standards suitable for computer-based image processing.

  19. Standard test method for amount of nonvolatile residue (NVR) in trichlorotrifluoroethane (Meseran procedure)

    SciTech Connect

    Not Available

    1980-01-01

    This method covers the quantitative determination of nonvolatile residues (NVR) in trichlorotrifluorethane (TCTFE) in the 0.1 to 100-ppM range using the technique of Evaporative Rate Analysis (ERA). Measurements are calibrated against preselected residues deposited by evaporation of standard solutions. This method is written specifically as a procedure for the determination of NVR which may exist in TCTFE when used as a cleaning solvent in precision cleaning operations of machined metal parts. USP liquid petrolatum heavy oil has been selected as the reference NVR. The general limits of accuracy are 0.1 ppM of NVR referred to a preselected reference standard. This level is achievable only when more than 1 ml of the solvent is evaporated. One-ppM levels may be detected on evaporation of 0.1 ml.

  20. Modification of standard proteinase K/phenol method for extraction of DNA from small tumour biopsies.

    PubMed

    Pitera, R; Pitera, J E; Mufti, G J; Salisbury, J R

    1993-09-01

    The standard proteinase K/phenol DNA isolation method was found to produce unsatisfactory yields of DNA from small tissue biopsies (less than 50 mg). The influences of the volume of cell lysis buffer and the amount of proteinase K on the final DNA yield and quality were studied, and an improved method was devised and compared with both the standard procedure and a phenol-free protocol. The optimal volume of cell lysis buffer was found to be 200 microliters per mg of tissue while the optimal amount of proteinase K was 60 micrograms per mg of tissue. A mean yield of 12 mu/mg tissue of pure, high molecular weight DNA was achieved from 50 frozen samples prepared by crushing. Yields from 20 microns thick cryostat sections reached 30 micrograms/mg.

  1. MUSQA: a CS method to build a multi-standard quality management system

    NASA Astrophysics Data System (ADS)

    Cros, Elizabeth; Sneed, Isabelle

    2002-07-01

    CS Communication & Systèmes, through its long quality management experience, has been able to build and evolve its Quality Management System according to clients requirements, norms, standards and models (ISO, DO178, ECSS, CMM, ...), evolving norms (transition from ISO 9001:1994 to ISO 9001:2000) and the TQM approach, being currently deployed. The aim of this paper is to show how, from this enriching and instructive experience, CS has defined and formalised its method: MuSQA (Multi-Standard Quality Approach). This method allows to built a new Quality Management System or simplify and unify an existing one. MuSQA objective is to provide any organisation with an open Quality Management System, which is able to evolve easily and turns to be a useful instrument for everyone, operational as well as non-operational staff.

  2. A method of preserving and testing the acceptability of gac fruit oil, a good source of beta-carotene and essential fatty acids.

    PubMed

    Vuong, L T; King, J C

    2003-06-01

    Gac fruit (Momordica cochinchinensis Spreng) is indigenous to Vietnam and other countries in Southeast Asia. Its seed pulp contains high concentrations of carotenoids, especially the provitamin A, beta-carotene. In northern Vietnam, gac fruits are seasonal and are mainly used in making a rice dish called xoi gac. The purpose of this study was to develop a method to collect and preserve gac fruit oil, to evaluate the nutritional composition of the oil, and to assess the acceptability of the gac oil by typical Vietnamese homemakers. One hundred women participated in training to learn how to prepare the fruits and operate the oil press. The women also participated in a survey of gac fruit use and their habitual use of animal fat and vegetable oil. Among all the participants in the training and surveys, 35 women actually produced oil from gac fruits grown in the village, using manual oil presses and locally available materials. The total carotene concentration in gac fruit oil was 5,700 micrograms/ml. The concentration of beta-carotene was 2,710 micrograms/ml. Sixty-nine percent of total fat was unsaturated, and 35% of that was polyunsaturated. The average daily consumption of gac fruit oil was estimated at 2 ml per person. The daily beta-carotene intake (from gac fruit oil) averaged approximately 5 mg per person. It was found that gac oil can be produced locally by village women using manual presses and locally available materials. The oil is a rich source of beta-carotene, vitamin E, and essential fatty acids. Although the beta-carotene concentration declines with time without a preservative or proper storage, it was still high after three months. The oil was readily accepted by the women and their children, and consumption of the oil increased the intake of beta-carotene and reduced the intake of lard. PMID:12891827

  3. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the “Borda” Method: a Pilot Study

    PubMed Central

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran’s public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called “Borda” in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software “Math-lab”7, “SPSS” 17 and Excel 2007 were used in this study. “Borda” estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance

  4. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the "Borda" Method: a Pilot Study.

    PubMed

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran's public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called "Borda" in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software "Math-lab"7, "SPSS" 17 and Excel 2007 were used in this study. "Borda" estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance decision making.

  5. A method of preserving and testing the acceptability of gac fruit oil, a good source of beta-carotene and essential fatty acids.

    PubMed

    Vuong, L T; King, J C

    2003-06-01

    Gac fruit (Momordica cochinchinensis Spreng) is indigenous to Vietnam and other countries in Southeast Asia. Its seed pulp contains high concentrations of carotenoids, especially the provitamin A, beta-carotene. In northern Vietnam, gac fruits are seasonal and are mainly used in making a rice dish called xoi gac. The purpose of this study was to develop a method to collect and preserve gac fruit oil, to evaluate the nutritional composition of the oil, and to assess the acceptability of the gac oil by typical Vietnamese homemakers. One hundred women participated in training to learn how to prepare the fruits and operate the oil press. The women also participated in a survey of gac fruit use and their habitual use of animal fat and vegetable oil. Among all the participants in the training and surveys, 35 women actually produced oil from gac fruits grown in the village, using manual oil presses and locally available materials. The total carotene concentration in gac fruit oil was 5,700 micrograms/ml. The concentration of beta-carotene was 2,710 micrograms/ml. Sixty-nine percent of total fat was unsaturated, and 35% of that was polyunsaturated. The average daily consumption of gac fruit oil was estimated at 2 ml per person. The daily beta-carotene intake (from gac fruit oil) averaged approximately 5 mg per person. It was found that gac oil can be produced locally by village women using manual presses and locally available materials. The oil is a rich source of beta-carotene, vitamin E, and essential fatty acids. Although the beta-carotene concentration declines with time without a preservative or proper storage, it was still high after three months. The oil was readily accepted by the women and their children, and consumption of the oil increased the intake of beta-carotene and reduced the intake of lard.

  6. Selecting the Acceptance Criteria of Medicines in the Reimbursement List of Public Health Insurance of Iran, Using the "Borda" Method: a Pilot Study.

    PubMed

    Viyanchi, Amir; Rasekh, Hamid Reza; Rajabzadeh Ghatari, Ali; SafiKhani, Hamid Reza

    2015-01-01

    Decision-making for medicines to be accepted in Iran's public health insurance reimbursement list is a complex process and involves factors, which should be considered in applying a coverage for medicine costs. These processes and factors are not wholly assessed, while assessment of these factors is an essential need for getting a transparent and evidence-based approach toward medicine reimbursement in Iran. This paper aims to show an evidence-based approach toward medicine selection criteria to inform the medical reimbursement decision makers in Iranian health insurance organizations. To explore an adaptable decision-making framework while incorporating a method called "Borda" in medicine reimbursement assessment, we used the help of an expert group including decision makers and clinical researchers who are also policy makers to appraise the five chief criteria that have three sub criteria (Precision, Interpretability, and Cost). Also software "Math-lab"7, "SPSS" 17 and Excel 2007 were used in this study. "Borda" estimates the amount of perceived values from different criteria and creates a range from one to five while providing a comprehensive measurement of a large spectrum of criteria. Participants reported that the framework provided an efficient approach to systematic consideration in a pragmatic format consisting of many parts to guide decision-makings, including criteria and value (a model with the core of Borda) and evidences (medicine reimbursement based on criteria). The most important criterion for medicine acceptance in health insurance companies, in Iran, is the "life-threatening" factor and "evidence quality" is accounted as the fifth important factor. This pilot study showed the usefulness of incorporating Borda in medicine reimbursement decisions to support a transparent and systematic appraisal of health insurance companies' deeds. Further research is needed to advance Borda-based approaches that are effective on health insurance decision making

  7. A novel method of drift-scanning stars suppression based on the standardized linear filter

    NASA Astrophysics Data System (ADS)

    Lin, Jianlin; Ping, Xijian; Hou, Guanghua; Ma, Debao

    2011-11-01

    A large number of stars in the drift-scanning star image have interfered with the detection of small target, this paper proposes an adaptive linear filtering method to achieve the small target detection by suppressing the stars. Firstly, the characteristics of stars, interest target and noise three different representative objects in the star image are analyzed, then the standardized linear filter is constructed to suppress the stars. For the purpose of decreasing the influence region of stars filtering uniformly, a gradient linear filter is constructed to modify the stars suppression method with the standardized linear filter. Then the filter parameter selection method is given. Finally, a multi-frame target track experiment on the real drift-scanning data is made to testify the validity of the proposed method. With the processing results of different methods, it has been showed that the proposed method for suppressing stars with different length and lean angle has a better effect, higher robustness and easier application than the others.

  8. Standardized methods for determination of benz-{alpha}-pyrene in hydrocarbons raw materials and products

    SciTech Connect

    Serkovskaya, G.S.

    1995-11-01

    In this article, the authors will summarize and correlate material on a standard method for the determination of a carcinogenic hydrocarbon - benz-{alpha}-pyrene (BP) - in petroleum crudes and products, and also in products from the processing of peat, coal, shales, and wood. The processing of petroleum, peat, coal, and shales yields exactly the same assortment of products in all cases: gasoline, kerosine, diesel fuel, lube oil, tar, residual fuel oil, heavy resid, pitch, bitumen, wax, paraffin wax, microcrystalline wax, and petrolatum.

  9. Standardization of Spore Inactivation Method for PMA-PhyloChip Analysis

    NASA Technical Reports Server (NTRS)

    Schrader, Michael

    2011-01-01

    In compliance with the Committee on Space Research (COSPAR) planetary protection policy, National Aeronautics and Space Administration (NASA) monitors the total microbial burden of spacecraft as a means for minimizing the inadvertent transfer of viable contaminant microorganisms to extraterrestrial environments (forward contamination). NASA standard assay-based counts are used both as a proxy for relative surface cleanliness and to estimate overall microbial burden as well as to assess whether forward planetary protection risk criteria are met for a given mission, which vary by the planetary body to be explored and whether or not life detection missions are present. Despite efforts to reduce presence of microorganisms from spacecraft prior to launch, microbes have been isolated from spacecraft and associated surfaces within the extreme conditions of clean room facilities using state of the art molecular technologies. Development of a more sensitive method that will better enumerate all viable microorganisms from spacecraft and associated surfaces could support future life detection missions. Current culture-based (NASA standard spore assay) and nucleic-acid-based polymerase chain reaction (PCR) methods have significant shortcomings in this type of analysis. The overall goal of this project is to evaluate and validate a new molecular method based on the use of a deoxyribonucleic acid (DNA) intercalating agent propidium monoazide (PMA). This is used in combination with DNA microarray (PhyloChip) which has been shown to identify very low levels of organisms on spacecraft associated surfaces. PMA can only penetrate the membrane of dead cells. Once penetrated, it intercalates the DNA and, upon photolysis using visible light it produces stable DNA monoadducts. This allows DNA to be unavailable for further PCR analysis. The specific aim of this study is to standardize the spore inactivation method for PMA-PhyloChip analysis. We have used the bacterial spores Bacillus

  10. Method for Standardizing Sonic-Boom Model Pressure Signatures Measured at Several Wind-Tunnel Facilities

    NASA Technical Reports Server (NTRS)

    Mack, Robert J.

    2007-01-01

    Low-boom model pressure signatures are often measured at two or more wind-tunnel facilities. Preliminary measurements are made at small separation distances in a wind tunnel close at hand, and a second set of pressure signatures is measured at larger separation distances in a wind-tunnel facility with a larger test section. In this report, a method for correcting and standardizing the wind-tunnel-measured pressure signatures obtained in different wind tunnel facilities is presented and discussed.

  11. The standard error of a weighted mean concentration—I. Bootstrapping vs other methods

    NASA Astrophysics Data System (ADS)

    Gatz, Donald F.; Smith, Luther

    Concentrations of chemical constituents of precipitation are frequently expressed in terms of the precipitation-weighted mean, which has several desirable properties. Unfortunately, the weighted mean has no analytical analog of the standard error of the arithmetic mean for use in characterizing its statistical uncertainty. Several approximate expressions have been used previously in the literature, but there is no consensus as to which is best. This paper compares three methods from the literature with a standard based on bootstrapping. Comparative calculations were carried out for nine major ions measured at 222 sampling sites in the National Atmospheric Deposition/National Trends Network (NADP/NTN). The ratio variance approximation of Cochran (1977) gave results that were not statistically different from those of bootstrapping, and is suggested as the method of choice for routine computing of the standard error of the weighted mean. The bootstrap method has advantages of its own, including the fact that it is nonparametric, but requires additional effort and computation time.

  12. An isotope-dilution standard GC/MS/MS method for steroid hormones in water

    USGS Publications Warehouse

    Foreman, William T.; Gray, James L.; ReVello, Rhiannon C.; Lindley, Chris E.; Losche, Scott A.

    2013-01-01

    An isotope-dilution quantification method was developed for 20 natural and synthetic steroid hormones and additional compounds in filtered and unfiltered water. Deuterium- or carbon-13-labeled isotope-dilution standards (IDSs) are added to the water sample, which is passed through an octadecylsilyl solid-phase extraction (SPE) disk. Following extract cleanup using Florisil SPE, method compounds are converted to trimethylsilyl derivatives and analyzed by gas chromatography with tandem mass spectrometry. Validation matrices included reagent water, wastewater-affected surface water, and primary (no biological treatment) and secondary wastewater effluent. Overall method recovery for all analytes in these matrices averaged 100%; with overall relative standard deviation of 28%. Mean recoveries of the 20 individual analytes for spiked reagent-water samples prepared along with field samples analyzed in 2009–2010 ranged from 84–104%, with relative standard deviations of 6–36%. Detection levels estimated using ASTM International’s D6091–07 procedure range from 0.4 to 4 ng/L for 17 analytes. Higher censoring levels of 100 ng/L for bisphenol A and 200 ng/L for cholesterol and 3-beta-coprostanol are used to prevent bias and false positives associated with the presence of these analytes in blanks. Absolute method recoveries of the IDSs provide sample-specific performance information and guide data reporting. Careful selection of labeled compounds for use as IDSs is important because both inexact IDS-analyte matches and deuterium label loss affect an IDS’s ability to emulate analyte performance. Six IDS compounds initially tested and applied in this method exhibited deuterium loss and are not used in the final method.

  13. Evaluation of a standard test method for screening fuels in soils

    SciTech Connect

    Sorini, S.S.; Schabron, J.F.

    1996-12-31

    A new screening method for fuel contamination in soils was recently developed as American Society for Testing and Materials (ASTM) Method D-5831-95, Standard Test Method for Screening Fuels in Soils. This method uses low-toxicity chemicals and can be sued to screen organic- rich soils, as well as being fast, easy, and inexpensive to perform. Fuels containing aromatic compounds, such as diesel fuel and gasoline, as well as other aromatic-containing hydrocarbon materials, such as motor oil, crude oil, and cola oil, can be determined. The screening method for fuels in soils was evaluated by conducting a Collaborative study on the method. In the Collaborative study, a sand and an organic soil spiked with various concentrations of diesel fuel were tested. Data from the Collaborative study were used to determine the reproducibility (between participants) and repeatability (within participants) precision of the method for screening the test materials. The Collaborative study data also provide information on the performance of portable field equipment (patent pending) versus laboratory equipment for performing the screening method and a comparison of diesel concentration values determined using the screening method versus a laboratory method.

  14. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods

    NASA Astrophysics Data System (ADS)

    Jha, Abhinav K.; Caffo, Brian; Frey, Eric C.

    2016-04-01

    The objective optimization and evaluation of nuclear-medicine quantitative imaging methods using patient data is highly desirable but often hindered by the lack of a gold standard. Previously, a regression-without-truth (RWT) approach has been proposed for evaluating quantitative imaging methods in the absence of a gold standard, but this approach implicitly assumes that bounds on the distribution of true values are known. Several quantitative imaging methods in nuclear-medicine imaging measure parameters where these bounds are not known, such as the activity concentration in an organ or the volume of a tumor. We extended upon the RWT approach to develop a no-gold-standard (NGS) technique for objectively evaluating such quantitative nuclear-medicine imaging methods with patient data in the absence of any ground truth. Using the parameters estimated with the NGS technique, a figure of merit, the noise-to-slope ratio (NSR), can be computed, which can rank the methods on the basis of precision. An issue with NGS evaluation techniques is the requirement of a large number of patient studies. To reduce this requirement, the proposed method explored the use of multiple quantitative measurements from the same patient, such as the activity concentration values from different organs in the same patient. The proposed technique was evaluated using rigorous numerical experiments and using data from realistic simulation studies. The numerical experiments demonstrated that the NSR was estimated accurately using the proposed NGS technique when the bounds on the distribution of true values were not precisely known, thus serving as a very reliable metric for ranking the methods on the basis of precision. In the realistic simulation study, the NGS technique was used to rank reconstruction methods for quantitative single-photon emission computed tomography (SPECT) based on their performance on the task of estimating the mean activity concentration within a known volume of interest

  15. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods.

    PubMed

    Jha, Abhinav K; Caffo, Brian; Frey, Eric C

    2016-04-01

    The objective optimization and evaluation of nuclear-medicine quantitative imaging methods using patient data is highly desirable but often hindered by the lack of a gold standard. Previously, a regression-without-truth (RWT) approach has been proposed for evaluating quantitative imaging methods in the absence of a gold standard, but this approach implicitly assumes that bounds on the distribution of true values are known. Several quantitative imaging methods in nuclear-medicine imaging measure parameters where these bounds are not known, such as the activity concentration in an organ or the volume of a tumor. We extended upon the RWT approach to develop a no-gold-standard (NGS) technique for objectively evaluating such quantitative nuclear-medicine imaging methods with patient data in the absence of any ground truth. Using the parameters estimated with the NGS technique, a figure of merit, the noise-to-slope ratio (NSR), can be computed, which can rank the methods on the basis of precision. An issue with NGS evaluation techniques is the requirement of a large number of patient studies. To reduce this requirement, the proposed method explored the use of multiple quantitative measurements from the same patient, such as the activity concentration values from different organs in the same patient. The proposed technique was evaluated using rigorous numerical experiments and using data from realistic simulation studies. The numerical experiments demonstrated that the NSR was estimated accurately using the proposed NGS technique when the bounds on the distribution of true values were not precisely known, thus serving as a very reliable metric for ranking the methods on the basis of precision. In the realistic simulation study, the NGS technique was used to rank reconstruction methods for quantitative single-photon emission computed tomography (SPECT) based on their performance on the task of estimating the mean activity concentration within a known volume of interest

  16. Double Standards: Using Teachers' Perceptions to Develop a Standards-Based Technology Integration Method for Social Studies

    ERIC Educational Resources Information Center

    Hineman, John M.

    2011-01-01

    This qualitative collective case study with an action research design identified teachers' perceptions of the use of technology in standards-based social studies education. Data were collected from semi-structured, one-on-one interviews conducted with a purposive sample of ten in-service social studies teachers from southwestern Pennsylvania.…

  17. Patients’ handling of a standardized medication plan: a pilot study and method development

    PubMed Central

    Botermann, Lea; Krueger, Katrin; Eickhoff, Christiane; Kloft, Charlotte; Schulz, Martin

    2016-01-01

    Purpose The Action Plan for Medication Safety by the German Federal Ministry of Health introduced a standardized medication plan (MP), a printable document for the patient. The practical handling needs to be tested before the nationwide implementation in Germany. Therefore, the aims of our study were 1) to develop an instrument to evaluate the usage of the standardized MP, 2) to assess if patients can locate, and 3) understand important information. Moreover, we explored patients’ opinion and suggestions regarding the standardized MP template. Patients and methods We conducted a cross-sectional study to evaluate the practical handling of the standardized MP. We interviewed 40 adult patients in seven community pharmacies in Germany, who took at least five medicines regularly and gave their written informed consent. The interview consisted of questions regarding finding and understanding information provided on a mock-up MP, patients’ opinion and the execution of the information on the MP by filling pill boxes. We eventually developed a new evaluation method to quantify the practical handling of the MP by rating the pill boxes filled by the patients. Results Overall, the participants rated the MP positively. Thirty-nine (98%) participants found important information on a mock-up standardized MP. Patients were questioned to identify if they understood information on medical intake as it relates to meals. In particular, they were questioned about medicine intake “1 hour before a meal”, which 98% (n=39) interpreted correctly, and “during a meal”, which 100% (n=40) interpreted correctly. The less precise advice of “before a meal” was interpreted correctly by 73% (n=29), and only 15% (n=6) correctly interpreted the term “after the meal”. The evaluation of the filled pill boxes resulted in the “Evaluation Tool to test the handling of the Medication Plan” (ET-MP) – a weighted scoring system. Conclusion The standardized MP is clearly arranged, and

  18. Impact of percentile computation method on PM 24-h air quality standard.

    PubMed

    Salako, Gbenga Oladoyin; Hopke, Philip K

    2012-09-30

    In 1997, the US Environmental Protection Agency (US EPA) introduced a percentile form of the National Ambient Air Quality Standard (NAAQS) for particulate matter (PM). Studies had shown that a specified percentile in the frequency distribution of measured values of PM increased the probability of detecting non-attainment areas (power) and decreased the likelihood of misclassification of attainment areas as being non-attainment (type 2 error). However, this new NAAQS used a percentile form that was different from a standard percentile in a distribution. Instead of taking the percentile of the distribution of the required 3 years of measurements, the PM(2.5) values for the selected percentile for each year were determined and the average of these 3 values was used as the NAAQS indicator value. However, no studies have been made of this average of the 3 years method and compared to a standard percentile in the multiyear data. The relationships between the values obtained using these two approaches have been explored. PM data measured at selected US EPA Aerometric Information Retrieval System (AIRS) website from January 2004 to December 2008 at 20 sites in 20 different states in United States were utilized. PM samples were collected for 24-h periods from midnight to midnight every third day for PM(2.5) and every sixth day for PM(10). At some sites, continuous measurements of PM(2.5) were made and averaged to provide 24-hr values. Using these data, the NAAQS percentile values were compared with the actual 98th percentile values of the three years of data. Regression and t-test analyses were used to compare these two methods and found high correlation coefficients and no significant difference in most cases. Overall, the two methods showed substantial agreement such that either of the two approaches could serve as the statistical form of the 24-h standard. In exploring the PM(10) standard, an arbitrarily chosen standard value of 85 μg/m(3) was used to explore the

  19. Research on bodies of the executed in German anatomy: an accepted method that changed during the Third Reich. Study of anatomical journals from 1924 to 1951.

    PubMed

    Hildebrandt, Sabine

    2013-04-01

    While it is known that bodies of the executed were used for anatomical research in Germany during the Third Reich, it is unclear whether this type of work was unique to the time period or more common in Germany than elsewhere. The dissected persons and the anatomists involved have not been fully investigated. This study of anatomical journals from 1924 to 1951 shows that 166 out of 7,438 [2.2%] German language articles mentioned the use of "material" from the bodies of executed persons. In comparison, only 2 out of 4,702 English language articles explicitly mentioned bodies of the executed. From 1924 to1932, 33 of a total of 3,734 [1%] German articles listed the use of the executed. From 1933 to 1938 the number rose to 46 out of 2,265 [2%], and increased again from 1939 to 1945 to 73 out of 984 [7%]. After the war 15 out of 455 [3%] still dealt with "material" from the executed. German anatomists' familiarity with the use of the executed as a standard for healthy tissues even before 1933 may have contributed to the ease with which they accepted the "opportunities" (large-scale studies and research on women) presented to them by unlimited access to bodies of the executed provided by the abusive National Socialist (NS) legislation and continued using them for some years after the war. German postwar anatomy was built in part on the bodies of NS victims. Information given in some publications will help with further identification of these victims.

  20. Towards a standardized method of developing quality indicators for palliative care: protocol of the Quality indicators for Palliative Care (Q-PAC) study

    PubMed Central

    2013-01-01

    Background In recent years, there have been several studies, using a wide variety of methods, aimed at developing quality indicators for palliative care. In this Quality Indicators for Palliative Care study (Q-PAC study) we have applied a scientifically rigorous method to develop a comprehensive and valid quality indicator set which can contribute to a standardized method for use in other countries. Methods and design Firstly, an extensive literature review identified existing international quality indicators and relevant themes for measuring quality in palliative care. Secondly, the most relevant of these were selected by an expert panel. Thirdly, those prioritized by the experts were scored by a second multidisciplinary expert panel for usability and relevance, in keeping with the RAND/UCLA-method, combining evidence with consensus among stakeholders. This panel included carers and policymakers as well as patients and next-of-kin. Fourthly, the draft set was tested and evaluated in practice for usability and feasibility; the indicators were then translated into questionnaires presented to patients, next-of-kin and care providers. To encourage the acceptance and use of the indicators, stakeholders, including national palliative care organizations, were involved throughout the whole project. Conclusion Our indicator development trajectory resulted in a set of quality indicators applicable to all patients in all palliative care settings. The set includes patient and relative perspectives and includes outcome, process and structure indicators. Our method can contribute internationally to a more standardized and rigorous approach to developing quality indicators for palliative care. PMID:23394401

  1. Generalized net analyte signal standard addition as a novel method for simultaneous determination: application in spectrophotometric determination of some pesticides.

    PubMed

    Asadpour-Zeynali, Karim; Saeb, Elhameh; Vallipour, Javad; Bamorowat, Mehdi

    2014-01-01

    Simultaneous spectrophotometric determination of three neonicotinoid insecticides (acetamiprid, imidacloprid, and thiamethoxam) by a novel method named generalized net analyte signal standard addition method (GNASSAM) in some binary and ternary synthetic mixtures was investigated. For this purpose, standard addition was performed using a single standard solution consisting of a mixture of standards of all analytes. Savings in time and amount of used materials are some of the advantages of this method. All determinations showed appropriate applicability of this method with less than 5% error. This method may be applied for linearly dependent data in the presence of known interferents. The GNASSAM combines the advantages of both the generalized standard addition method and net analyte signal; therefore, it may be a proper alternative for some other multivariate methods. PMID:24672886

  2. Standardized phenology monitoring methods to track plant and animal activity for science and resource management applications

    NASA Astrophysics Data System (ADS)

    Denny, Ellen G.; Gerst, Katharine L.; Miller-Rushing, Abraham J.; Tierney, Geraldine L.; Crimmins, Theresa M.; Enquist, Carolyn A. F.; Guertin, Patricia; Rosemartin, Alyssa H.; Schwartz, Mark D.; Thomas, Kathryn A.; Weltzin, Jake F.

    2014-05-01

    Phenology offers critical insights into the responses of species to climate change; shifts in species' phenologies can result in disruptions to the ecosystem processes and services upon which human livelihood depends. To better detect such shifts, scientists need long-term phenological records covering many taxa and across a broad geographic distribution. To date, phenological observation efforts across the USA have been geographically limited and have used different methods, making comparisons across sites and species difficult. To facilitate coordinated cross-site, cross-species, and geographically extensive phenological monitoring across the nation, the USA National Phenology Network has developed in situ monitoring protocols standardized across taxonomic groups and ecosystem types for terrestrial, freshwater, and marine plant and animal taxa. The protocols include elements that allow enhanced detection and description of phenological responses, including assessment of phenological "status", or the ability to track presence-absence of a particular phenophase, as well as standards for documenting the degree to which phenological activity is expressed in terms of intensity or abundance. Data collected by this method can be integrated with historical phenology data sets, enabling the development of databases for spatial and temporal assessment of changes in status and trends of disparate organisms. To build a common, spatially, and temporally extensive multi-taxa phenological data set available for a variety of research and science applications, we encourage scientists, resources managers, and others conducting ecological monitoring or research to consider utilization of these standardized protocols for tracking the seasonal activity of plants and animals.

  3. Standardized phenology monitoring methods to track plant and animal activity for science and resource management applications.

    PubMed

    Denny, Ellen G; Gerst, Katharine L; Miller-Rushing, Abraham J; Tierney, Geraldine L; Crimmins, Theresa M; Enquist, Carolyn A F; Guertin, Patricia; Rosemartin, Alyssa H; Schwartz, Mark D; Thomas, Kathryn A; Weltzin, Jake F

    2014-05-01

    Phenology offers critical insights into the responses of species to climate change; shifts in species' phenologies can result in disruptions to the ecosystem processes and services upon which human livelihood depends. To better detect such shifts, scientists need long-term phenological records covering many taxa and across a broad geographic distribution. To date, phenological observation efforts across the USA have been geographically limited and have used different methods, making comparisons across sites and species difficult. To facilitate coordinated cross-site, cross-species, and geographically extensive phenological monitoring across the nation, the USA National Phenology Network has developed in situ monitoring protocols standardized across taxonomic groups and ecosystem types for terrestrial, freshwater, and marine plant and animal taxa. The protocols include elements that allow enhanced detection and description of phenological responses, including assessment of phenological "status", or the ability to track presence-absence of a particular phenophase, as well as standards for documenting the degree to which phenological activity is expressed in terms of intensity or abundance. Data collected by this method can be integrated with historical phenology data sets, enabling the development of databases for spatial and temporal assessment of changes in status and trends of disparate organisms. To build a common, spatially, and temporally extensive multi-taxa phenological data set available for a variety of research and science applications, we encourage scientists, resources managers, and others conducting ecological monitoring or research to consider utilization of these standardized protocols for tracking the seasonal activity of plants and animals.

  4. Standardized phenology monitoring methods to track plant and animal activity for science and resource management applications

    USGS Publications Warehouse

    Denny, Ellen G.; Gerst, Katharine L.; Miller-Rushing, Abraham J.; Tierney, Geraldine L.; Crimmins, Theresa M.; Enquist, Carolyn A.F.; Guertin, Patricia; Rosemartin, Alyssa H.; Schwartz, Mark D.; Thomas, Kathryn A.; Weltzin, Jake F.

    2014-01-01

    Phenology offers critical insights into the responses of species to climate change; shifts in species’ phenologies can result in disruptions to the ecosystem processes and services upon which human livelihood depends. To better detect such shifts, scientists need long-term phenological records covering many taxa and across a broad geographic distribution. To date, phenological observation efforts across the USA have been geographically limited and have used different methods, making comparisons across sites and species difficult. To facilitate coordinated cross-site, cross-species, and geographically extensive phenological monitoring across the nation, the USA National Phenology Network has developed in situ monitoring protocols standardized across taxonomic groups and ecosystem types for terrestrial, freshwater, and marine plant and animal taxa. The protocols include elements that allow enhanced detection and description of phenological responses, including assessment of phenological “status”, or the ability to track presence–absence of a particular phenophase, as well as standards for documenting the degree to which phenological activity is expressed in terms of intensity or abundance. Data collected by this method can be integrated with historical phenology data sets, enabling the development of databases for spatial and temporal assessment of changes in status and trends of disparate organisms. To build a common, spatially, and temporally extensive multi-taxa phenological data set available for a variety of research and science applications, we encourage scientists, resources managers, and others conducting ecological monitoring or research to consider utilization of these standardized protocols for tracking the seasonal activity of plants and animals.

  5. Reconsideration of methods and standards: Digestion of diaper wipes and use of matrix-matched calibration standards for dust lead analysis

    SciTech Connect

    Orlova, A.O.; Losh, L.N.; Bannon, D.I.; Lees, P.S.J.; Chisolm, J.J. Jr.; Farfel, M.R.

    1999-12-15

    Diaper wipes are widely used for sampling residential dust for lead analysis. A thicker type of diaper wipe was incompletely digested and had low recoveries of lead on stock solution spikes using existing protocols. A modified protocol was applied to various quality control samples prepared with thicker diaper wipes in 134 batches of field samples. Modifications included a larger reagent volume, more concentrated acid, 3 h on the hot plate, and squeezing wipe residues during filtration. Seventeen batches were reanalyzed using matrix-matched standards. Acceptable lead recoveries were obtained for stock solution spikes (88%) and spikes prepared with leaded dust-SRM 2582 (88%), SRM 2589 (96%), and CRMO 14-050 (99%). Matrix-matched calibration standards increased mean lead recoveries by an additional 8%. Their protocol may provide a basis for a standard operational procedure for wipe digestion and analysis. Differences in estimates of dust lead loadings attributable to the type of wipe and to sample preparation and calibration procedures have implications for risk assessment, clearance testing, and comparability of laboratory data. Reconsideration of current protocols for wipe materials, wipe digestion, and judging laboratory performance is warranted.

  6. [The non-damaging method for the insertion of a standard electrode for cochlear ossification].

    PubMed

    Diab, Kh M; Daikhes, N A; Pashchinina, O A; Siraeva, A R; Kuznetsov, A O

    2016-01-01

    The objective of the present study was to develop the non-damaging method for the insertion of a standard electrode for cochlear ossification with a view to improving the results of hearing and speech rehabilitation of the patients presenting with grade IV sensorineural impairment of hearing. Twenty preparations of the cadaveric temporal bone were used to investigate topographic and anatomical relationships in the main structures of the middle and internal ears, viz. the second cochlear coil, vestibulum and its windows, processus cochleaformis, spiral lamina, and modiolus. The optimal method for the insertion of a standard electrode into the spiral canal of the cochlea after the removal of the ossified structures is proposed. The optimal site for constructing the second colostomy is determined that allows the spiral plate and modiolus to be maximally preserved. The proposed method was employed to treat 11 patients with grade IV sensorineural impairment of hearing and more than 5 mm ossification of the basal cochlear coil. With this method, it proved possible to insert the maximum number of electrodes into the cochlear spiral canal and thereby to obtain excellent results of hearing and speech rehabilitation in the patients with the ossified cochlea. PMID:27367352

  7. A comparative clinical study on standardization of Vamana Vidhi by classical and traditional methods

    PubMed Central

    Dass, Ranjip Kumar; Bhatt, Nilesh N.; Thakar, Anup B.; Shukla, Vagish Dutt

    2012-01-01

    Vamana Karma (process of emesis) is considered as Pradhana Karma (prime procedure) meant for inducing therapeutic vomiting, indicated for the purification of Urdhwa Bhaga (upper part) of the body. It is the process by which contents of stomach, including Kapha and Pitta are expelled out of the body through oral route. Acharya Charak and Sushruta have advocated various procedures for Vamana Karma known as classical methods, whereas some traditional methods are also being followed. As very little works has been carried out in the direction of Vamana Karma and as not a single work has been carried out on standardization of Vamana Vidhi comparing to both classical and traditional methods, the present study had been selected. The clinical trial was conducted in a randomized sample of 50 individuals (Both patients and volunteers) resolved into two sub-groups, viz. individuals in Group A was performed Vamana with classical methods and Group B with traditional methods. From the observations and results obtained in the present clinical study, it can be concluded that the method mentioned in classics is very much beneficial from every point of view in comparison to the traditional method. It is very easy, safest, less time-consuming and clinically as well as statistically most effective method without producing any type of complications. PMID:23723669

  8. A comparative clinical study on standardization of Vamana Vidhi by classical and traditional methods.

    PubMed

    Dass, Ranjip Kumar; Bhatt, Nilesh N; Thakar, Anup B; Shukla, Vagish Dutt

    2012-10-01

    Vamana Karma (process of emesis) is considered as Pradhana Karma (prime procedure) meant for inducing therapeutic vomiting, indicated for the purification of Urdhwa Bhaga (upper part) of the body. It is the process by which contents of stomach, including Kapha and Pitta are expelled out of the body through oral route. Acharya Charak and Sushruta have advocated various procedures for Vamana Karma known as classical methods, whereas some traditional methods are also being followed. As very little works has been carried out in the direction of Vamana Karma and as not a single work has been carried out on standardization of Vamana Vidhi comparing to both classical and traditional methods, the present study had been selected. The clinical trial was conducted in a randomized sample of 50 individuals (Both patients and volunteers) resolved into two sub-groups, viz. individuals in Group A was performed Vamana with classical methods and Group B with traditional methods. From the observations and results obtained in the present clinical study, it can be concluded that the method mentioned in classics is very much beneficial from every point of view in comparison to the traditional method. It is very easy, safest, less time-consuming and clinically as well as statistically most effective method without producing any type of complications. PMID:23723669

  9. PV standards overview

    NASA Astrophysics Data System (ADS)

    DeBlasio, Richard

    1997-02-01

    A brief historical perspective and current status of the on going evolution of photovoltaic standards development and the use of these standards in promulgating accepted practices used in producing, measuring, and deploying Photovoltaic (PV) components and systems in the field. After nearly 20 years of experience in developing and writing domestic and international consensus PV standards the need and importance of standard methods and practices continues, as in the past, to be essential for a maturing PV industry. Part of this maturity has been in establishing and maintaining a common ground through the development of consensus standards and furthering the use of standards for PV commercialization in support of test facility accreditation, product certification, systems deployment, and safety code development to assure PV quality, performance, reliability, and safety.

  10. Standardization of Nanoparticle Characterization: Methods for Testing Properties, Stability, and Functionality of Edible Nanoparticles.

    PubMed

    McClements, Jake; McClements, David Julian

    2016-06-10

    There has been a rapid increase in the fabrication of various kinds of edible nanoparticles for oral delivery of bioactive agents, such as those constructed from proteins, carbohydrates, lipids, and/or minerals. It is currently difficult to compare the relative advantages and disadvantages of different kinds of nanoparticle-based delivery systems because researchers use different analytical instruments and protocols to characterize them. In this paper, we briefly review the various analytical methods available for characterizing the properties of edible nanoparticles, such as composition, morphology, size, charge, physical state, and stability. This information is then used to propose a number of standardized protocols for characterizing nanoparticle properties, for evaluating their stability to environmental stresses, and for predicting their biological fate. Implementation of these protocols would facilitate comparison of the performance of nanoparticles under standardized conditions, which would facilitate the rational selection of nanoparticle-based delivery systems for different applications in the food, health care, and pharmaceutical industries.

  11. A method for determining the number of documents needed for a gold standard corpus.

    PubMed

    Juckett, David

    2012-06-01

    The unstructured narratives in medicine have been increasingly targeted for content extraction using the techniques of natural language processing (NLP). In most cases, these efforts are facilitated by creating a manually annotated set of narratives containing the ground truth; commonly referred to as a gold standard corpus. This corpus is used for modeling, fine-tuning, and testing NLP software as well as providing the basis for training in machine learning. Determining the number of annotated documents (size) for this corpus is important, but rarely described; rather, the factors of cost and time appear to dominate decision-making about corpus size. In this report, a method is outlined to determine gold standard size based on the capture probabilities for the unique words within a target corpus. To demonstrate this method, a corpus of dictation letters from the Michigan Pain Consultant (MPC) clinics for pain management are described and analyzed. A well-formed working corpus of 10,000 dictations was first constructed to provide a representative subset of the total, with no more than one dictation letter per patient. Each dictation was divided into words and common words were removed. The Poisson function was used to determine probabilities of word capture within samples taken from the working corpus, and then integrated over word length to give a single capture probability as a function of sample size. For these MPC dictations, a sample size of 500 documents is predicted to give a capture probability of approximately 0.95. Continuing the demonstration of sample selection, a provisional gold standard corpus of 500 documents was selected and examined for its similarity to the MPC structured coding and demographic data available for each patient. It is shown that a representative sample, of justifiable size, can be selected for use as a gold standard.

  12. Standards for the Analysis and Processing of Surface-Water Data and Information Using Electronic Methods

    USGS Publications Warehouse

    Sauer, Vernon B.

    2002-01-01

    Surface-water computation methods and procedures are described in this report to provide standards from which a completely automated electronic processing system can be developed. To the greatest extent possible, the traditional U. S. Geological Survey (USGS) methodology and standards for streamflow data collection and analysis have been incorporated into these standards. Although USGS methodology and standards are the basis for this report, the report is applicable to other organizations doing similar work. The proposed electronic processing system allows field measurement data, including data stored on automatic field recording devices and data recorded by the field hydrographer (a person who collects streamflow and other surface-water data) in electronic field notebooks, to be input easily and automatically. A user of the electronic processing system easily can monitor the incoming data and verify and edit the data, if necessary. Input of the computational procedures, rating curves, shift requirements, and other special methods are interactive processes between the user and the electronic processing system, with much of this processing being automatic. Special computation procedures are provided for complex stations such as velocity-index, slope, control structures, and unsteady-flow models, such as the Branch-Network Dynamic Flow Model (BRANCH). Navigation paths are designed to lead the user through the computational steps for each type of gaging station (stage-only, stagedischarge, velocity-index, slope, rate-of-change in stage, reservoir, tide, structure, and hydraulic model stations). The proposed electronic processing system emphasizes the use of interactive graphics to provide good visual tools for unit values editing, rating curve and shift analysis, hydrograph comparisons, data-estimation procedures, data review, and other needs. Documentation, review, finalization, and publication of records are provided for with the electronic processing system, as

  13. Perceptions and acceptability of mHealth interventions for improving patient care at a community-based HIV/AIDS clinic in Uganda: a mixed methods study

    PubMed Central

    Chang, Larry W; Njie-Carr, Veronica; Kalenge, Sheila; Kelly, Jack F; Bollinger, Robert C; Alamo-Talisuna, Stella

    2013-01-01

    mHealth (mobile technologies for health) represents a growing array of tools being applied in diverse health care settings. mHealth interventions for improving HIV/AIDS care is a promising strategy, but its evidence-base is limited. We conducted a formative research evaluation to inform the development of novel, mHealth HIV/AIDS care interventions to be used by community health workers (CHWs) in Kampala, Uganda. A mixed methods formative research approach was utilized. Qualitative methods included 20 in-depth interviews and 6 focus groups with CHWs, clinic staff, and patients. Thematic analysis was performed and selected quotations used to illustrate themes. Quantitative methods consisted of a survey administered to CHWs and clinic staff using categorical and Likert scale questions regarding current mobile phone and internet access and perceptions on the potential use of smartphones by CHWs. Qualitative results included themes on significant current care challenges, multiple perceived mHealth benefits, and general intervention acceptability. Key mHealth features desired included tools to verify CHW task completions, clinical decision support tools, and simple access to voice calling. Inhibiting factors identified included concerns about CHW job security and unrealistic expectations of mHealth capabilities. Quantitative results from 27 staff participants found that 26 (96%) did not have internet access at home; yet, only 2 (7.4%) did not own a mobile phone. Likert scale survey responses (1–5, 1=Strongly Disagree, 5=Strongly Agree) indicated general agreement that smartphones would improve efficiency (Mean=4.35) and patient care (4.31) but might be harmful to patient confidentiality (3.88) and training was needed (4.63). Qualitative and quantitative results were generally consistent, and, overall, there was enthusiasm for mHealth technology. However, a number of potential inhibiting factors were also discovered. Findings from this study may help guide future design

  14. Mass standards - a high-precision study of commonly used methods for cleaning stainless steel weights

    NASA Astrophysics Data System (ADS)

    Davidson, Stuart; Severn, Ian; Bayliss, David

    2002-08-01

    Studies have been carried out of the effects of using three different cleaning methods on 1 kg stainless steel mass standards, all three methods being suitable for use in a mass calibration laboratory. The methods investigated were manual and ultrasonic cleaning using solvents, and boiling in pure water. Boiling in pure water proved the most effective and additionally produced the most stable weights with stabilities of better than 1 part in 108 over a period of months. Ultrasonic cleaning was almost as effective as boiling but the weights were less stable after the cleaning process. Manual cleaning proved the least effective and the mass change produced was very dependent on the specific cleaning technique. Finally, a summary of the key features of each cleaning technique is given.

  15. Simultaneous kinetic determination of levodopa and carbidopa by H-point standard addition method.

    PubMed

    Safavi, Afsaneh; Tohidi, Maryam

    2007-05-01

    The kinetic H-point standard addition method (HPSAM) was applied to the simultaneous determination of levodopa and carbidopa. The method was based on the difference in the rate of oxidation of these compounds with Cu(II)-neocuproine system and formation of Cu(I)-neocuproine complex at pH 5.5. The absorbance of the Cu(I)-neocuproine complex was monitored at 453 nm. Experimental conditions such as pH, reagent concentrations, ionic strength and temperature were optimized. Simultaneous determination of levodopa and carbidopa was performed in the range of 0.8-4 and 0.2-1.5 microg ml(-1), respectively. The proposed method was applied to the simultaneous determination of levodopa and carbidopa in pharmaceutical samples, and satisfactory results were obtained.

  16. Influence of respirometry methods on intraspecific variation in standard metabolic rates in newts.

    PubMed

    Kristín, Peter; Gvoždík, Lumír

    2012-09-01

    Standard metabolic rate (SMR) is both a highly informative and variable trait. Variation in SMR stems not only from diverse intrinsic and extrinsic factors, but also from the use of diverse methods for metabolic measurements. We measured CO(2) production (VCO(2)) and oxygen consumption rates (VO(2)) using two flow-through respirometry modes, continuous and intermittent (stop-flow), to evaluate their potential contribution to SMR variation in Alpine newts, Ichthyosaura alpestris. Both respirometry modes yielded similar and repeatable VCO(2) values. Although VO(2) was highly repeatable, continuous respirometry produced lower VO(2) than the intermittent method. During intermittent measurements, the total number of activity bouts was higher than during continuous respirometry trials. Statistical correction for disparate activity levels minimized variation in oxygen consumption between respirometry modes. We conclude that use of either method of flow-through respirometry, if properly applied, introduced less noise to SMR estimates than a variation in activity levels.

  17. Methods proposed to achieve air quality standards for mobile sources and technology surveillance.

    PubMed Central

    Piver, W T

    1975-01-01

    The methods proposed to meet the 1975 Standards of the Clean Air Act for mobile sources are alternative antiknocks, exhaust emission control devices, and alternative engine designs. Technology surveillance analysis applied to this situation is an attempt to anticipate potential public and environmental health problems from these methods, before they happen. Components of this analysis are exhaust emission characterization, environmental transport and transformation, levels of public and environmental exposure, and the influence of economics on the selection of alternative methods. The purpose of this presentation is to show trends as a result of the interaction of these different components. In no manner can these trends be interpreted explicitly as to what will really happen. Such an analysis is necessary so that public and environmental health officials have the opportunity to act on potential problems before they become manifest. PMID:50944

  18. A comparison of standard cultural methods for the detection of foodborne Salmonella.

    PubMed

    D'Aoust, J Y; Sewell, A M; Warburton, D W

    1992-05-01

    The sensitivity of the standard cultural method of the International Organization for Standardization (ISO 6579 and ISO 3565 combined) was compared to that of the Health Protection Branch (HPB) procedure for the detection of foodborne Salmonella. Of 195 foods tested, 84 (43.1%) were found to contain salmonellae by one or more cultural conditions. Of these, 75 (89.3%) and 68 (81.0%) were identified by the ISO and HPB methods, respectively. The apparent lack of agreement between both methods likely stemmed from the low indigenous numbers of salmonellae in several food homogenates, and unequal transfer of the target microorganism into homologous ISO and HPB pre-enrichment broths. The sensitivities of the commercially available Muller-Kauffmann tetrathionate broth (MKTBG43, Oxoid CM343), and a closely-related medium prepared with Oxoid CM29 tetrathionate base varied from 86.9 to 89.3%, and were deemed equivalent to that obtained with the ISO formulation of MKTBG43 (89.3%). Comparatively fewer contaminated samples were identified from selenite cystine (SC35) and selenite brilliant green (SBG35) enrichment cultures (82.1-83.3%). The high selectivity and saccharide-independent response of the bismuth sulfite agar medium warrants its consideration as a mandatory plating medium in ISO methodologies for the effective detection of typical and atypical biotypes of foodborne Salmonella spp.

  19. An improved method for evaluating ideal standards in self-perception and mate preferences.

    PubMed

    Katsena, Lasma; Dimdins, Girts

    2015-04-01

    The aim of the study was to improve the methodology for measuring ideals of self-perception and mate preferences. The Ideal Standards Model (ISM; Fletcher, Simpson, Thomas & Giles, 1999) was used as a basis for development of the scale. It was further modified by adding a number of items from previous studies. Data were collected from 223 participants, aged 19 to 27 years. The results suggested that a modified five-factor version of the ISM is an appropriate method for evaluation of ideal characteristics. The five factors are warmth/ trustworthiness, status/ resources, intelligence, social skills and physical attractiveness. PMID:25580983

  20. [A standardized AgNOR stain method for formalin fixed and paraffin embedded material].

    PubMed

    Ofner, D; Bankfalvi, A; Riehemann, K; Böcker, W; Schmid, K W

    1994-08-01

    Visualization of proteins associated with nucleolar organizer regions proteins (AgNORs) on formalin-fixed and paraffin-embedded archival tissues is substantially improved after application of wet autoclave pretreatment. Silver staining results are comparable to those obtained on tissues processed in alcohol based fixatives, illustrating AgNORs as substructures of the nucleoli without any staining artefacts. A highly reproducible staining quality was achieved irrespective of tissue origin or duration of formalin fixation. As a result of this novel and simple method, the grounds have been prepared for standardized AgNOR quantification on archival material.

  1. An improved method for evaluating ideal standards in self-perception and mate preferences.

    PubMed

    Katsena, Lasma; Dimdins, Girts

    2015-04-01

    The aim of the study was to improve the methodology for measuring ideals of self-perception and mate preferences. The Ideal Standards Model (ISM; Fletcher, Simpson, Thomas & Giles, 1999) was used as a basis for development of the scale. It was further modified by adding a number of items from previous studies. Data were collected from 223 participants, aged 19 to 27 years. The results suggested that a modified five-factor version of the ISM is an appropriate method for evaluation of ideal characteristics. The five factors are warmth/ trustworthiness, status/ resources, intelligence, social skills and physical attractiveness.

  2. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 3, 0.03 Superstructure

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented on asset determinant factor/CAS profile codes/CAS cost process; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. Deficiency standards and inspection methods are presented for beams; pre-engineered building systems; floors; roof structure; stairs; and fireproofing.

  3. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 7, 0.07 Conveying

    SciTech Connect

    Not Available

    1993-05-01

    System information is given for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; and system work breakdown structure. Deficiency standards and inspection methods are presented for elevators and special conveyors.

  4. Standardization based on human factors for 3D display: performance characteristics and measurement methods

    NASA Astrophysics Data System (ADS)

    Uehara, Shin-ichi; Ujike, Hiroyasu; Hamagishi, Goro; Taira, Kazuki; Koike, Takafumi; Kato, Chiaki; Nomura, Toshio; Horikoshi, Tsutomu; Mashitani, Ken; Yuuki, Akimasa; Izumi, Kuniaki; Hisatake, Yuzo; Watanabe, Naoko; Umezu, Naoaki; Nakano, Yoshihiko

    2010-02-01

    We are engaged in international standardization activities for 3D displays. We consider that for a sound development of 3D displays' market, the standards should be based on not only mechanism of 3D displays, but also human factors for stereopsis. However, we think that there is no common understanding on what the 3D display should be and that the situation makes developing the standards difficult. In this paper, to understand the mechanism and human factors, we focus on a double image, which occurs in some conditions on an autostereoscopic display. Although the double image is generally considered as an unwanted effect, we consider that whether the double image is unwanted or not depends on the situation and that there are some allowable double images. We tried to classify the double images into the unwanted and the allowable in terms of the display mechanism and visual ergonomics for stereopsis. The issues associated with the double image are closely related to performance characteristics for the autostereoscopic display. We also propose performance characteristics, measurement and analysis methods to represent interocular crosstalk and motion parallax.

  5. Proficiency of Nerve Conduction using Standard Methods and Reference Values (Cl. NPhys Trial 4)

    PubMed Central

    Litchy, William J.; Albers, James W.; Wolfe, James; Bolton, Charles F.; Walsh, Nancy; Klein, Christopher J.; Zafft, Andrew J.; Russell, James W.; Thomas, Karen; Overland, Carol J.; Davies, Jenny L.; Carter, Rickey E.; Dyck, Peter J.

    2014-01-01

    Introduction Cl. NPhys Trial 3 showed that attributes of nerve conduction (NC) were without significant intra-observer differences but showed significant inter-observer differences. Methods Trial 4 tests whether use of written instructions, pre-trial agreement on techniques, and use of standard reference values, diagnostic percentile values, or broader categorization of abnormality reduces significant inter-observer disagreement and improves agreement among clinical neurophysiologists. Results and Discussion The Trial 4 modifications markedly decreased but did not eliminate significant inter-observer differences of measured attributes of NC. Use of standard reference values and defined percentile values of abnormality decreased inter-observer disagreement and improved agreement of judgment of abnormality among evaluators. Therefore, the same clinical neurophysiologist should perform repeat NCs of therapeutic trial patients. Differences in inter-observer judgment of abnormality decrease with use of common standard reference values and a defined percentile level of abnormality, providing a rationale for their use in therapeutic trials and medical practice. PMID:24644133

  6. Standardization of Type 2 Diabetes Outpatient Expenditure with Bundled Payment Method in China

    PubMed Central

    Xu, Guo-Chao; Luo, Yun; Li, Qian; Wu, Meng-Fan; Zhou, Zi-Jun

    2016-01-01

    Background: In recent years, the prevalence of type 2 diabetes among Chinese population has been increasing by years, directly leading to an average annual growth rate of 19.90% of medical expenditure. Therefore, it is urgent to work on strategies to control the growth of medical expenditure on type 2 diabetes on the basis of the reality of China. Therefore, in this study, we explored the feasibility of implementing bundled payment in China through analyzing bundled payment standards of type 2 diabetes outpatient services. Methods: This study analyzed the outpatient expenditure on type 2 diabetes with Beijing Urban Employee's Basic Medical Insurance from 2010 to 2012. Based on the analysis of outpatient expenditure and its influential factors, we adopted decision tree approach to conduct a case-mix analysis. In the end, we built a case-mix model to calculate the standard expenditure and the upper limit of each combination. Results: We found that age, job status, and whether with complication were significant factors that influence outpatient expenditure for type 2 diabetes. Through the analysis of the decision tree, we used six variables (complication, age, diabetic foot, diabetic nephropathy, cardiac-cerebrovascular disease, and neuropathy) to group the cases, and obtained 11 case-mix groups. Conclusions: We argued that it is feasible to implement bundled payment on type 2 diabetes outpatient services. Bundled payment is effective to control the increase of outpatient expenditure. Further improvements are needed for the implementation of bundled payment reimbursement standards, together with relevant policies and measures. PMID:27064041

  7. Apollo experience report environmental acceptance testing

    NASA Technical Reports Server (NTRS)

    Laubach, C. H. M.

    1976-01-01

    Environmental acceptance testing was used extensively to screen selected spacecraft hardware for workmanship defects and manufacturing flaws. The minimum acceptance levels and durations and methods for their establishment are described. Component selection and test monitoring, as well as test implementation requirements, are included. Apollo spacecraft environmental acceptance test results are summarized, and recommendations for future programs are presented.

  8. Composite scheme using localized relaxation with non-standard finite difference method for hyperbolic conservation laws

    NASA Astrophysics Data System (ADS)

    Kumar, Vivek; Raghurama Rao, S. V.

    2008-04-01

    Non-standard finite difference methods (NSFDM) introduced by Mickens [ Non-standard Finite Difference Models of Differential Equations, World Scientific, Singapore, 1994] are interesting alternatives to the traditional finite difference and finite volume methods. When applied to linear hyperbolic conservation laws, these methods reproduce exact solutions. In this paper, the NSFDM is first extended to hyperbolic systems of conservation laws, by a novel utilization of the decoupled equations using characteristic variables. In the second part of this paper, the NSFDM is studied for its efficacy in application to nonlinear scalar hyperbolic conservation laws. The original NSFDMs introduced by Mickens (1994) were not in conservation form, which is an important feature in capturing discontinuities at the right locations. Mickens [Construction and analysis of a non-standard finite difference scheme for the Burgers-Fisher equations, Journal of Sound and Vibration 257 (4) (2002) 791-797] recently introduced a NSFDM in conservative form. This method captures the shock waves exactly, without any numerical dissipation. In this paper, this algorithm is tested for the case of expansion waves with sonic points and is found to generate unphysical expansion shocks. As a remedy to this defect, we use the strategy of composite schemes [R. Liska, B. Wendroff, Composite schemes for conservation laws, SIAM Journal of Numerical Analysis 35 (6) (1998) 2250-2271] in which the accurate NSFDM is used as the basic scheme and localized relaxation NSFDM is used as the supporting scheme which acts like a filter. Relaxation schemes introduced by Jin and Xin [The relaxation schemes for systems of conservation laws in arbitrary space dimensions, Communications in Pure and Applied Mathematics 48 (1995) 235-276] are based on relaxation systems which replace the nonlinear hyperbolic conservation laws by a semi-linear system with a stiff relaxation term. The relaxation parameter ( λ) is chosen locally

  9. 49 CFR 193.2303 - Construction acceptance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Construction acceptance. 193.2303 Section 193.2303 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...: FEDERAL SAFETY STANDARDS Construction § 193.2303 Construction acceptance. No person may place in...

  10. Offer/Acceptance Ratio.

    ERIC Educational Resources Information Center

    Collins, Mimi

    1997-01-01

    Explores how human resource professionals, with above average offer/acceptance ratios, streamline their recruitment efforts. Profiles company strategies with internships, internal promotion, cooperative education programs, and how to get candidates to accept offers. Also discusses how to use the offer/acceptance ratio as a measure of program…

  11. Interlaboratory reproducibility of standard accelerated aging methods for oxidation of UHMWPE.

    PubMed

    Kurtz, S M; Muratoglu, O K; Buchanan, F; Currier, B; Gsell, R; Greer, K; Gualtieri, G; Johnson, R; Schaffner, S; Sevo, K; Spiegelberg, S; Shen, F W; Yau, S S

    2001-07-01

    During accelerating aging, experimental uncertainty may arise due to variability in the oxidation process, or due to limitations in the technique that is ultimately used to measure oxidation. The purpose of the present interlaboratory study was to quantify the repeatability and reproducibility of standard accelerated aging methods for ultra-high molecular weight polyethylene (UHMWPE). Sections (200 microm thick) were microtomed from the center of an extruded rod of GUR 4150 HP, gamma irradiated in air or nitrogen, and circulated to 12 institutions in the United States and Europe for characterization of oxidation before and after accelerated aging. Specimens were aged for 3 weeks at 80 degrees C in an air circulating oven or for 2 weeks at 70 degrees C in an oxygen bomb (maintained at 503 kPa (5 atm.) of O2) in accordance with the two standard protocols described in ASTM F 2003-00. FTIR spectra were collected from each specimen within 24 h of the start and finish of accelerated aging, and oxidation indices were calculated by normalizing the peak area of the carbonyl region by the reference peak areas at 1370 or 2022 cm(-1). The mean relative interlaboratory uncertainty of the oxidation data was 78.5% after oven aging and 129.1% after bomb aging. The oxidation index measurement technique was not found to be a significant factor in the reproducibility. Comparable relative intrainstitutional uncertainty was observed after oven aging and bomb aging. For both aging methods, institutions successfully discriminated between air-irradiated and control specimens. However, the large interinstitutional variation suggests that absolute performance standards for the oxidation index of UHMWPE after accelerated aging may not be practical at the present time.

  12. [Principles and Methods for Formulating National Standards of "Regulations of Acupuncture-nee- dle Manipulating techniques"].

    PubMed

    Gang, Wei-juan; Wang, Xin; Wang, Fang; Dong, Guo-feng; Wu, Xiao-dong

    2015-08-01

    The national standard of "Regulations of Acupuncture-needle Manipulating Techniques" is one of the national Criteria of Acupuncturology for which a total of 22 items have been already established. In the process of formulation, a series of common and specific problems have been met. In the present paper, the authors expound these problems from 3 aspects, namely principles for formulation, methods for formulating criteria, and considerations about some problems. The formulating principles include selection and regulations of principles for technique classification and technique-related key factors. The main methods for formulating criteria are 1) taking the literature as the theoretical foundation, 2) taking the clinical practice as the supporting evidence, and 3) taking the expounded suggestions or conclusions through peer review.

  13. Gravimetric approach to the standard addition method in instrumental analysis. 1.

    PubMed

    Kelly, W Robert; MacDonald, Bruce S; Guthrie, William F

    2008-08-15

    A mathematical formulation for a gravimetric approach to the univariate standard addition method (SAM) is presented that has general applicability for both liquids and solids. Using gravimetry rather than volumetry reduces the preparation time, increases design flexibility, and makes increased accuracy possible. SAM has most often been used with analytes in aqueous solutions that are aspirated into flames or plasmas and determined by absorption, emission, or mass spectrometric techniques. The formulation presented here shows that the method can also be applied to complex matrixes, such as distillate and residual fuel oils, using techniques such as X-ray fluorescence (XRF) or combustion combined with atomic fluorescence or absorption. These techniques, which can be subject to matrix-induced interferences, could realize the same benefits that have been demonstrated for dilute aqueous solutions.

  14. Hanford Dose Overview Program: standardized methods and data for Hanford environmental dose calculations. Rev. 1

    SciTech Connect

    McCormack, W.D.; Ramsdell, J.V.; Napier, B.A.

    1984-05-01

    This document serves as a guide to Hanford contractors for obtaining or performing Hanford-related environmental dose calculations. Because environmental dose estimation techniques are state-of-the-art and are continually evolving, the data and standard methods presented herein will require periodic revision. This document is scheduled to be updated annually, but actual changes to the program will be made more frequently if required. For this reason, PNL's Occupational and Environmental Protection Department should be contacted before any Hanford-related environmental dose calculation is performed. This revision of the Hanford Dose Overview Program Report primarily reflects changes made to the data and models used in calculating atmospheric dispersion of airborne effluents at Hanford. The modified data and models are described in detail. In addition, discussions of dose calculation methods and the review of calculation results have been expanded to provide more explicit guidance to the Hanford contractors. 19 references, 30 tables.

  15. Method of simulating spherical voids for use as a radiographic standard

    DOEpatents

    Foster, Billy E.

    1977-01-01

    A method of simulating small spherical voids in metal is provided. The method entails drilling or etching a hemispherical depression of the desired diameter in each of two sections of metal, the sections being flat plates or different diameter cylinders. A carbon bead is placed in one of the hemispherical voids and is used as a guide to align the second hemispherical void with that in the other plate. The plates are then bonded together with epoxy, tape or similar material and the two aligned hemispheres form a sphere within the material; thus a void of a known size has been created. This type of void can be used to simulate a pore in the development of radiographic techniques of actual voids (porosity) in welds and serve as a radiographic standard.

  16. Accuracy of standard measures of family planning service quality: findings from the simulated client method.

    PubMed

    Tumlinson, Katherine; Speizer, Ilene S; Curtis, Siân L; Pence, Brian W

    2014-12-01

    In the field of international family planning, quality of care as a reproductive right is widely endorsed, yet we lack validated data-collection instruments that can accurately assess quality in terms of its public health importance. This study, conducted within 19 public and private facilities in Kisumu, Kenya, used the simulated client method to test the validity of three standard data-collection instruments used in large-scale facility surveys: provider interviews, client interviews, and observation of client-provider interactions. Results found low specificity and low positive predictive values in each of the three instruments for a number of quality indicators, suggesting that the quality of care provided may be overestimated by traditional methods of measurement. Revised approaches to measuring family planning service quality may be needed to ensure accurate assessment of programs and to better inform quality-improvement interventions.

  17. Accuracy of standard measures of family planning service quality: findings from the simulated client method.

    PubMed

    Tumlinson, Katherine; Speizer, Ilene S; Curtis, Siân L; Pence, Brian W

    2014-12-01

    In the field of international family planning, quality of care as a reproductive right is widely endorsed, yet we lack validated data-collection instruments that can accurately assess quality in terms of its public health importance. This study, conducted within 19 public and private facilities in Kisumu, Kenya, used the simulated client method to test the validity of three standard data-collection instruments used in large-scale facility surveys: provider interviews, client interviews, and observation of client-provider interactions. Results found low specificity and low positive predictive values in each of the three instruments for a number of quality indicators, suggesting that the quality of care provided may be overestimated by traditional methods of measurement. Revised approaches to measuring family planning service quality may be needed to ensure accurate assessment of programs and to better inform quality-improvement interventions. PMID:25469929

  18. Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method.

    PubMed

    Pohanka, Miroslav; Hrabinova, Martina; Kuca, Kamil; Simonato, Jean-Pierre

    2011-01-01

    Assay of acetylcholinesterase (AChE) activity plays an important role in diagnostic, detection of pesticides and nerve agents, in vitro characterization of toxins and drugs including potential treatments for Alzheimer's disease. These experiments were done in order to determine whether indoxylacetate could be an adequate chromogenic reactant for AChE assay evaluation. Moreover, the results were compared to the standard Ellman's method. We calculated Michaelis constant Km (2.06 × 10(-4) mol/L for acetylthiocholine and 3.21 × 10(-3) mol/L for indoxylacetate) maximum reaction velocity V(max) (4.97 × 10(-7) kat for acetylcholine and 7.71 × 10(-8) kat for indoxylacetate) for electric eel AChE. In a second part, inhibition values were plotted for paraoxon, and reactivation efficacy was measured for some standard oxime reactivators: obidoxime, pralidoxime (2-PAM) and HI-6. Though indoxylacetate is split with lower turnover rate, this compound appears as a very attractive reactant since it does not show any chemical reactivity with oxime antidots and thiol used for the Ellman's method. Thus it can be advantageously used for accurate measurement of AChE activity. Suitability of assay for butyrylcholinesterase activity assessment is also discussed.

  19. Standardizing chromatin research: a simple and universal method for ChIP-seq

    PubMed Central

    Arrigoni, Laura; Richter, Andreas S.; Betancourt, Emily; Bruder, Kerstin; Diehl, Sarah; Manke, Thomas; Bönisch, Ulrike

    2016-01-01

    Chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) is a key technique in chromatin research. Although heavily applied, existing ChIP-seq protocols are often highly fine-tuned workflows, optimized for specific experimental requirements. Especially the initial steps of ChIP-seq, particularly chromatin shearing, are deemed to be exceedingly cell-type-specific, thus impeding any protocol standardization efforts. Here we demonstrate that harmonization of ChIP-seq workflows across cell types and conditions is possible when obtaining chromatin from properly isolated nuclei. We established an ultrasound-based nuclei extraction method (NEXSON: Nuclei EXtraction by SONication) that is highly effective across various organisms, cell types and cell numbers. The described method has the potential to replace complex cell-type-specific, but largely ineffective, nuclei isolation protocols. By including NEXSON in ChIP-seq workflows, we completely eliminate the need for extensive optimization and sample-dependent adjustments. Apart from this significant simplification, our approach also provides the basis for a fully standardized ChIP-seq and yields highly reproducible transcription factor and histone modifications maps for a wide range of different cell types. Even small cell numbers (∼10 000 cells per ChIP) can be easily processed without application of modified chromatin or library preparation protocols. PMID:26704968

  20. Technology transfer through a network of standard methods and recommended practices - The case of petrochemicals

    NASA Astrophysics Data System (ADS)

    Batzias, Dimitris F.; Karvounis, Sotirios

    2012-12-01

    Technology transfer may take place in parallel with cooperative action between companies participating in the same organizational scheme or using one another as subcontractor (outsourcing). In this case, cooperation should be realized by means of Standard Methods and Recommended Practices (SRPs) to achieve (i) quality of intermediate/final products according to specifications and (ii) industrial process control as required to guarantee such quality with minimum deviation (corresponding to maximum reliability) from preset mean values of representative quality parameters. This work deals with the design of the network of SRPs needed in each case for successful cooperation, implying also the corresponding technology transfer, effectuated through a methodological framework developed in the form of an algorithmic procedure with 20 activity stages and 8 decision nodes. The functionality of this methodology is proved by presenting the path leading from (and relating) a standard test method for toluene, as petrochemical feedstock in the toluene diisocyanate production, to the (6 generations distance upstream) performance evaluation of industrial process control systems (ie., from ASTM D5606 to BS EN 61003-1:2004 in the SRPs network).

  1. Standardizing chromatin research: a simple and universal method for ChIP-seq.

    PubMed

    Arrigoni, Laura; Richter, Andreas S; Betancourt, Emily; Bruder, Kerstin; Diehl, Sarah; Manke, Thomas; Bönisch, Ulrike

    2016-04-20

    Chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) is a key technique in chromatin research. Although heavily applied, existing ChIP-seq protocols are often highly fine-tuned workflows, optimized for specific experimental requirements. Especially the initial steps of ChIP-seq, particularly chromatin shearing, are deemed to be exceedingly cell-type-specific, thus impeding any protocol standardization efforts. Here we demonstrate that harmonization of ChIP-seq workflows across cell types and conditions is possible when obtaining chromatin from properly isolated nuclei. We established an ultrasound-based nuclei extraction method (NEXSON: Nuclei EXtraction by SONication) that is highly effective across various organisms, cell types and cell numbers. The described method has the potential to replace complex cell-type-specific, but largely ineffective, nuclei isolation protocols. By including NEXSON in ChIP-seq workflows, we completely eliminate the need for extensive optimization and sample-dependent adjustments. Apart from this significant simplification, our approach also provides the basis for a fully standardized ChIP-seq and yields highly reproducible transcription factor and histone modifications maps for a wide range of different cell types. Even small cell numbers (∼10,000 cells per ChIP) can be easily processed without application of modified chromatin or library preparation protocols.

  2. A comparison of standard methods for measuring water vapour permeability of fabrics

    NASA Astrophysics Data System (ADS)

    McCullough, Elizabeth A.; Kwon, Myoungsook; Shim, Huensup

    2003-08-01

    It is difficult for outdoor apparel manufacturers to interpret the technical information provided by fabric suppliers concerning fabric 'breathability' properties because different methods and test conditions are used. In addition, fabrics with hydrophilic components change their properties under different humidity conditions. The purpose of this study was to measure the water vapour permeability and evaporative resistance of 26 different waterproof, windproof and breathable shell fabrics using five standard test methods. The water vapour transmission rate (WVTR) was measured using the ASTM E 96 upright and inverted cup tests with water, the JIS L 1099 desiccant inverted cup test and the new ASTM F 2298 standard using the dynamic moisture permeation cell (DMPC). The evaporative resistance was measured using the ISO 11092 sweating hot plate test. The WVTRs were consistently highest when measured with the desiccant inverted cup, followed by the inverted cup, DMPC and upright cup. The upright cup was significantly correlated with the DMPC (0.97), and the desiccant inverted cup was correlated to the sweating hot plate (-0.91).

  3. A method for the accurate and smooth approximation of standard thermodynamic functions

    NASA Astrophysics Data System (ADS)

    Coufal, O.

    2013-01-01

    A method is proposed for the calculation of approximations of standard thermodynamic functions. The method is consistent with the physical properties of standard thermodynamic functions. This means that the approximation functions are, in contrast to the hitherto used approximations, continuous and smooth in every temperature interval in which no phase transformations take place. The calculation algorithm was implemented by the SmoothSTF program in the C++ language which is part of this paper. Program summaryProgram title:SmoothSTF Catalogue identifier: AENH_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AENH_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3807 No. of bytes in distributed program, including test data, etc.: 131965 Distribution format: tar.gz Programming language: C++. Computer: Any computer with gcc version 4.3.2 compiler. Operating system: Debian GNU Linux 6.0. The program can be run in operating systems in which the gcc compiler can be installed, see http://gcc.gnu.org/install/specific.html. RAM: 256 MB are sufficient for the table of standard thermodynamic functions with 500 lines Classification: 4.9. Nature of problem: Standard thermodynamic functions (STF) of individual substances are given by thermal capacity at constant pressure, entropy and enthalpy. STF are continuous and smooth in every temperature interval in which no phase transformations take place. The temperature dependence of STF as expressed by the table of its values is for further application approximated by temperature functions. In the paper, a method is proposed for calculating approximation functions which, in contrast to the hitherto used approximations, are continuous and smooth in every temperature interval. Solution method: The approximation functions are

  4. Microbial diversity and methodological diversity: When standardized methods may or may not be beneficial in deep subseafloor biosphere research

    NASA Astrophysics Data System (ADS)

    Darch, P. T.

    2015-12-01

    Scientists are often encouraged, and sometimes required, to standardize methods for collecting, analyzing, managing, and reporting data. Methods standardization within and between scientific domains is often considered beneficial for collaboration, developing scientific tools, and curation and sharing of data. However, efforts to standardize are often resisted for a range of social and technical reasons. Here we present findings from a case study of a domain characterized by high methodological diversity. This domain, the deep subseafloor biosphere, studies interactions between subseafloor microbial communities and the physical environment they inhabit. We have conducted 49 interviews and observed practice over a period of 18 months; the study is still ongoing. Domain scientists depend on core samples and data obtained from International Ocean Discovery Program (IODP) cruises. During cruises, basic data are produced about the physical composition of cores, using standard methods. However, no comparable microbiological data is produced on cruises. Many leading deep subseafloor biosphere scientists are concerned that this lack of standardized microbiological data limits their domain's scientific progress. They have identified heterogeneity of methods for microbiological analyses of cores as the major barrier to including such analyses on cruises. Among the actions these scientists have taken to promote methods standardization are journal articles and an international workshop. Despite these efforts, the community is not fully embracing standardization. One of the tensions is between perceived benefits for the community vs. a lack of incentives for individuals to perform necessary standardization work. This work includes meta-analyses to compare methods. However, the community lacks infrastructure and reward structures to support individuals to conduct such work. Another tension is concern amongst some scientists that standardizing methods now will foreclose

  5. DOE standard: Firearms safety

    SciTech Connect

    1996-02-01

    Information in this document is applicable to all DOE facilities, elements, and contractors engaged in work that requires the use of firearms as provided by law or contract. The standard in this document provides principles and practices for implementing a safe and effective firearms safety program for protective forces and for non-security use of firearms. This document describes acceptable interpretations and methods for meeting Order requirements.

  6. Digital angiography in the pediatric patient with congenital heart disease: comparison with standard methods

    SciTech Connect

    Levin, A.R.; Goldberg, H.L.; Borer, J.S.; Rothenberg, L.N.; Nolan, F.A.; Engle, M.A.; Cohen, B.; Skelly, N.T.; Carter, J.

    1983-08-01

    Digital subtraction angiography (DSA) permits high-resolution cardiac imaging with relatively low doses of contrast medium and reduced radiation exposure. These are potential advantages in children with congenital heart disease. Computer-based DSA (30 frames/sec) and conventional cutfilm angiography (6 frames/sec) or cineangiography (60 frames/sec) were compared in 42 patients, ages 2 months to 18 years (mean 7.8 years) and weighing 3.4 to 78.5 kg (mean 28.2 kg). There were 29 diagnoses that included valvular regurgitant lesions, obstructive lesions, various shunt abnormalities, and a group of miscellaneous anomalies. For injections made at a site distant from the lesion and on the right side of the circulation, the mean dose of contrast medium was 60% to 100% of the conventional dose given during standard angiography. With injections made close to the lesion and on the left side of the circulation, the mean dose of contrast medium was 27.5% to 42% of the conventional dose. Radiation exposure for each technique was markedly reduced in all age groups. A total of 92 digital subtraction angiograms were performed. Five studies were suboptimal because too little contrast medium was injected; in the remaining 87 injections, DSA and conventional studies resulted in identical diagnoses in 81 instances (p less than .001 vs chance). The remaining six injections made during DSA failed to confirm diagnoses made angiographically by standard cutfilm angiography or cineangiography. We conclude that DSA usually provides diagnostic information equivalent to that available from cutfilm angiography and cineangiography, but DSA requires considerably lower doses of contrast medium and less radiation exposure than standard conventional methods.

  7. Evaluation of Advanced Stirling Convertor Net Heat Input Correlation Methods Using a Thermal Standard

    NASA Technical Reports Server (NTRS)

    Briggs, Maxwell H.; Schifer, Nicholas A.

    2012-01-01

    The U.S. Department of Energy (DOE) and Lockheed Martin Space Systems Company (LMSSC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. This generator would use two high-efficiency Advanced Stirling Convertors (ASCs), developed by Sunpower Inc. and NASA Glenn Research Center (GRC). The ASCs convert thermal energy from a radioisotope heat source into electricity. As part of ground testing of these ASCs, different operating conditions are used to simulate expected mission conditions. These conditions require achieving a particular operating frequency, hot end and cold end temperatures, and specified electrical power output for a given net heat input. In an effort to improve net heat input predictions, numerous tasks have been performed which provided a more accurate value for net heat input into the ASCs, including testing validation hardware, known as the Thermal Standard, to provide a direct comparison to numerical and empirical models used to predict convertor net heat input. This validation hardware provided a comparison for scrutinizing and improving empirical correlations and numerical models of ASC-E2 net heat input. This hardware simulated the characteristics of an ASC-E2 convertor in both an operating and non-operating mode. This paper describes the Thermal Standard testing and the conclusions of the validation effort applied to the empirical correlation methods used by the Radioisotope Power System (RPS) team at NASA Glenn.

  8. Relation between the national handbook of recommended methods for water data acquisition and ASTM standards

    USGS Publications Warehouse

    Glysson, G. Douglas; Skinner, John V.

    1991-01-01

    In the late 1950's, intense demands for water and growing concerns about declines in the quality of water generated the need for more water-resources data. About thirty Federal agencies, hundreds of State, county and local agencies, and many private organizations had been collecting water data. However, because of differences in procedures and equipment, many of the data bases were incompatible. In 1964, as a step toward establishing more uniformity, the Bureau of the Budget (now the Office of Management and Budget, OMB) issued 'Circular A-67' which presented guidelines for collecting water data and also served as a catalyst for creating the Office of Water Data Coordination (OWDC) within the U.S. Geological Survey. This paper discusses past, present, and future aspects of the relation between methods in the National Handbook and standards published by ASTM (American Society for Testing and Materials) Committee D-19 on Water's Subcommittee D-19.07 on Sediment, Geomorphology, and Open Channel Flow. The discussion also covers historical aspects of standards - development work jointly conducted by OWDC and ASTM.

  9. Standardized methods to quantify thrombogenicity of blood-contacting materials via thromboelastography.

    PubMed

    Shankarraman, Venkat; Davis-Gorman, Grace; Copeland, Jack G; Caplan, Michael R; McDonagh, Paul F

    2012-01-01

    Blood coagulation is the most significant complication of vascular biomaterials. A straightforward, sensitive, and standard measure of the compatibility of these materials with whole blood (hemocompatibility) is necessary to avoid coagulation. Current techniques used quantify only individual clotting components and are poor predictors of coagulation. The thromboelastograph (TEG) provides a measure of overall clot formation from whole blood. Although TEG is very common in clinical settings, its application to biomaterials is limited partly due to difficulty in sample preparation. In this protocol, whole blood samples are incubated with (1) biomaterials (tube with clamped ends) and (2) endothelial cells cultured on biomaterial surfaces (12-well plate) under controlled shearing conditions (10 rpm on rocker, at 37°C), and then the blood is transferred to the TEG to measure clot formation. TEG clearly discriminates among the R-times (time until initial clot formation) of expanded poly(tetrafluoroethylene), poly(urethane), and Tygon tubing. Marked differences in R-time are also seen when endothelial cells are cultured on various extracellular matrix proteins and proteoglycans. Thus, R-time provides a robust metric of overall thrombogenicity of biomaterials, and these procedures provide a standardized method for TEG to facilitate direct comparison among candidate biomaterials undergoing in-vitro testing.

  10. Methods for TEM analysis of NIST's single-walled carbon nanotube Standard Reference Material

    NASA Astrophysics Data System (ADS)

    Mansfield, Elisabeth; Geiss, Roy; Fagan, Jeffrey A.

    2009-08-01

    The National Institute of Standards and Technology (NIST) will soon release a series of single-walled carbon nanotube (SWCNT) reference materials (RMs) to provide users with a well-characterized material for their applications. The SWCNT reference material will be introduced as a series of three types of material: (1) raw soot characterized for composition, which will be certified as a Standard Reference Material, (2) purified (greater than 90 % SWCNT by weight) bucky paper and (3) dispersed, length-sorted populations characterized by length. The instrumental characterization of NIST's SWCNT reference materials is extensive, and this paper aims to provide researchers with dispersion preparation methods for TEM (transmission electron microscopy) analysis of the SWCNT raw soot. A selection of dispersing solvents, including organic solvents, aqueous surfactants and DNA dispersions, were prepared and examined by TEM. Recommendations for sample preparation of the SWCNT SRM 2483 to yield images similar to those presented here are given. Examples of images of the length-sorted SWCNT reference material are also shown. These results illustrate the importance of optimal dispersion to enable imaging of SWCNT characteristics.

  11. Building profile input program - a standardized method for calculating building downwash input values

    SciTech Connect

    Eckhoff, P.A.

    1994-12-31

    Building downwash is a complex technical subject that has important ramifications in the field of air quality dispersion modeling. Building downwash algorithms have been incorporated into air quality dispersion models such as the Industrial Source Complex (ISC2) Models, short term and long term versions (ISCST2 and ISCLT2). Input data preparation for these algorithms must reflect Environmental Protection Agency (EPA) guidance on Good Engineering Practice (GEP) stack height and building downwash. The current guidance is complex and errors can easily be made in the input data preparation. A computer program called the Building Profile Input Program (BPIP) was written to alleviate errors caused during input data preparation and to provide a standardized method for calculating building height (BH) and projected building width (PBW) values for input to the ISC2 models that reflect EPA guidance.

  12. Canonical integration and analysis of periodic maps using non-standard analysis and life methods

    SciTech Connect

    Forest, E.; Berz, M.

    1988-06-01

    We describe a method and a way of thinking which is ideally suited for the study of systems represented by canonical integrators. Starting with the continuous description provided by the Hamiltonians, we replace it by a succession of preferably canonical maps. The power series representation of these maps can be extracted with a computer implementation of the tools of Non-Standard Analysis and analyzed by the same tools. For a nearly integrable system, we can define a Floquet ring in a way consistent with our needs. Using the finite time maps, the Floquet ring is defined only at the locations s/sub i/ where one perturbs or observes the phase space. At most the total number of locations is equal to the total number of steps of our integrator. We can also produce pseudo-Hamiltonians which describe the motion induced by these maps. 15 refs., 1 fig.

  13. Developing a Standard Method for Link-Layer Security of CCSDS Space Communications

    NASA Technical Reports Server (NTRS)

    Biggerstaff, Craig

    2009-01-01

    Communications security for space systems has been a specialized field generally far removed from considerations of mission interoperability and cross-support in fact, these considerations often have been viewed as intrinsically opposed to security objectives. The space communications protocols defined by the Consultative Committee for Space Data Systems (CCSDS) have a twenty-five year history of successful use in over 400 missions. While the CCSDS Telemetry, Telecommand, and Advancing Orbiting Systems protocols for use at OSI Layer 2 are operationally mature, there has been no direct support within these protocols for communications security techniques. Link-layer communications security has been successfully implemented in the past using mission-unique methods, but never before with an objective of facilitating cross-support and interoperability. This paper discusses the design of a standard method for cryptographic authentication, encryption, and replay protection at the data link layer that can be integrated into existing CCSDS protocols without disruption to legacy communications services. Integrating cryptographic operations into existing data structures and processing sequences requires a careful assessment of the potential impediments within spacecraft, ground stations, and operations centers. The objective of this work is to provide a sound method for cryptographic encapsulation of frame data that also facilitates Layer 2 virtual channel switching, such that a mission may procure data transport services as needed without involving third parties in the cryptographic processing, or split independent data streams for separate cryptographic processing.

  14. Non-standard numerical methods applied to subsurface biobarrier formation models in porous media.

    PubMed

    Chen, B M; Kojouharov, H V

    1999-07-01

    Biofilm forming microbes have complex effects on the flow properties of natural porous media. Subsurface biofilms have the potential for the formation of biobarriers to inhibit contaminant migration in groundwater. Another example of beneficial microbial effects is the biotransformation of organic contaminants to less harmful forms, thereby providing an in situ method for treatment of contaminated groundwater supplies. Mathematical models that describe contaminant transport with biodegradation involve a set of coupled convection-dispersion equations with non-linear reactions. The reactive solute transport equation is one for which numerical solution procedures continue to exhibit significant limitations for certain problems of groundwater hydrology interest. Accurate numerical simulations are crucial to the development of contaminant remediation strategies. A new numerical method is developed for simulation of reactive bacterial transport in porous media. The non-standard numerical approach is based on the ideas of the 'exact' time-stepping scheme. It leads to solutions free from the numerical instabilities that arise from incorrect modeling of derivatives and reaction terms. Applications to different biofilm models are examined and numerical results are presented to demonstrate the performance of the proposed new method.

  15. Simplified Symptom Pattern Method for verbal autopsy analysis: multisite validation study using clinical diagnostic gold standards

    PubMed Central

    2011-01-01

    Background Verbal autopsy can be a useful tool for generating cause of death data in data-sparse regions around the world. The Symptom Pattern (SP) Method is one promising approach to analyzing verbal autopsy data, but it has not been tested rigorously with gold standard diagnostic criteria. We propose a simplified version of SP and evaluate its performance using verbal autopsy data with accompanying true cause of death. Methods We investigated specific parameters in SP's Bayesian framework that allow for its optimal performance in both assigning individual cause of death and in determining cause-specific mortality fractions. We evaluated these outcomes of the method separately for adult, child, and neonatal verbal autopsies in 500 different population constructs of verbal autopsy data to analyze its ability in various settings. Results We determined that a modified, simpler version of Symptom Pattern (termed Simplified Symptom Pattern, or SSP) performs better than the previously-developed approach. Across 500 samples of verbal autopsy testing data, SSP achieves a median cause-specific mortality fraction accuracy of 0.710 for adults, 0.739 for children, and 0.751 for neonates. In individual cause of death assignment in the same testing environment, SSP achieves 45.8% chance-corrected concordance for adults, 51.5% for children, and 32.5% for neonates. Conclusions The Simplified Symptom Pattern Method for verbal autopsy can yield reliable and reasonably accurate results for both individual cause of death assignment and for determining cause-specific mortality fractions. The method demonstrates that verbal autopsies coupled with SSP can be a useful tool for analyzing mortality patterns and determining individual cause of death from verbal autopsy data. PMID:21816099

  16. Implementing College and Career Standards in Math Methods Course for Early Childhood and Elementary Education Teacher Candidates

    ERIC Educational Resources Information Center

    Lee, Joohi

    2016-01-01

    This study is purposed to measure the efficacy of implementing College and Career Readiness Standards (CCRS) math standards into math methods courses for early childhood and elementary education teacher candidates at an urban university located in the Dallas and Fort Worth metroplex area. A total of 161 college seniors (teacher candidates)…

  17. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 8, 0.08 Mechanical, Book 1

    SciTech Connect

    Not Available

    1993-05-01

    System information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet too & material listing; testing methods; inspection frequency; standard system design life tables; and system work breakdown structure. Deficiency standards are given for plumbing, fire protection, heating, cooling, and special (drinking water cooling systems).

  18. Condition Assessment survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 9, 0.09 Electrical, Book 1

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; and system work breakdown structure. Deficiency standards are presented for service & distribution; lighting; and special systems.

  19. Comparison of Web-Based and Face-to-Face Standard Setting Using the Angoff Method

    ERIC Educational Resources Information Center

    Katz, Irvin R.; Tannenbaum, Richard J.

    2014-01-01

    Web-based standard setting holds promise for reducing the travel and logistical inconveniences of traditional, face-to-face standard setting meetings. However, because there are few published reports of setting standards via remote meeting technology, little is known about the practical potential of the approach, including technical feasibility of…

  20. A Semi-Automatic Alignment Method for Math Educational Standards Using the MP (Materialization Pattern) Model

    ERIC Educational Resources Information Center

    Choi, Namyoun

    2010-01-01

    Educational standards alignment, which matches similar or equivalent concepts of educational standards, is a necessary task for educational resource discovery and retrieval. Automated or semi-automated alignment systems for educational standards have been recently available. However, existing systems frequently result in inconsistency in…

  1. A Standard Setting Method Designed for Complex Performance Assessments with Multiple Performance Categories: Categorical Assignments of Student Work.

    ERIC Educational Resources Information Center

    Plake, Barbara S.; Hambleton, Ronald K.

    This paper reports on a standard-setting method designed for complex performance assessments with multiple performance categories. The method studied, the Analytical Judgment Method, involves panelists' making analytical classification decisions for each of the test's components individually. It also allows for discussion and reconsideration of…

  2. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 1, 0.01 Foundations and footings

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. Deficiency standards and inspection methods are given for footings - spread/strip/grade beams; foundation walls; foundation dampproofing/waterproofing; excavation/backfill/ and piles & caissons.

  3. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 5, 0.05 Roofing

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; and system work breakdown structure. Deficiency standards and inspection methods are presented for built-up membrane; single- ply membrane; metal roofing systems; coated foam membrane; shingles; tiles; parapets; roof drainage system; roof specialties; and skylights.

  4. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 6, 0.06 Interior construction

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. Deficiency standards and inspection methods are presented for conventional and specialty partitions, toilet partitions & accessories, interior doors, paint finishes/coatings/ wall covering systems; floor finishing systems; and ceiling systems.

  5. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 11, 0.11 Specialty systems

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. Deficiency standards and inspection methods are presented for canopies; loading dock systems; tanks; domes (bulk storage, metal framing); louvers & vents; access floors; integrated ceilings; and mezzanine structures.

  6. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 12, 0.12 Sitework

    SciTech Connect

    Not Available

    1993-05-01

    General information is presented for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. Deficiency standards and inspection methods are given for utility distribution systems, central heating, central cooling, electrical, utility support structures, paving roadways/walkways, and tunnels.

  7. Standard regression-based methods for measuring recovery after sport-related concussion.

    PubMed

    McCrea, Michael; Barr, William B; Guskiewicz, Kevin; Randolph, Christopher; Marshall, Stephen W; Cantu, Robert; Onate, James A; Kelly, James P

    2005-01-01

    Clinical decision making about an athlete's return to competition after concussion is hampered by a lack of systematic methods to measure recovery. We applied standard regression-based methods to statistically measure individual rates of impairment at several time points after concussion in college football players. Postconcussive symptoms, cognitive functioning, and balance were assessed in 94 players with concussion (based on American Academy of Neurology Criteria) and 56 noninjured controls during preseason baseline testing, and immediately, 3 hr, and 1, 2, 3, 5, and 7 days postinjury. Ninety-five percent of injured players exhibited acute concussion symptoms and impairment on cognitive or balance testing immediately after injury, which diminished to 4% who reported elevated symptoms on postinjury day 7. In addition, a small but clinically significant percentage of players who reported being symptom free by day 2 continued to be classified as impaired on the basis of objective balance and cognitive testing. These data suggest that neuropsychological testing may be of incremental utility to subjective symptom checklists in identifying the residual effects of sport-related concussion. The implementation of neuropsychological testing to detect subtle cognitive impairment is most useful once postconcussive symptoms have resolved. This management model is also supported by practical and other methodological considerations.

  8. Sampling and analysis of microcystins: Implications for the development of standardized methods.

    PubMed

    Tillmanns, Angeline R; Pick, Frances R; Aranda-Rodriguez, Rocio

    2007-04-01

    Microcystins (MC), a group of cyanotoxins, have been found in lakes and rivers worldwide. One goal of MC research is to develop models which predict MC concentrations, but these efforts have been hampered by a lack of standardized methods necessary for comparing data across studies. Here, we investigate the effect of chemical analysis (HPLC-PDA and ELISA), sample collection (whole water, plankton tow and surface scum), and choice of normalizing parameter (volume, dry weight, and chlorophyll a) on reported MC concentrations. Samples were collected over three years from a temperate mesotrophic, shallow lake with episodic blooms of cyanobacteria. We found that microcystins were up to four times higher in lake samples when analyzed by ELISA relative to HPLC-PDA and that MC concentration measured by HPLC explained less than half of the variation in MC concentrations measured by ELISA. Also, samples collected by plankton tow gave consistently higher concentrations than whole water samples. An additional HPLC analysis of two chlorophyte cultures revealed the presence of compounds with a similar UV absorbance spectrum to MC-LR, suggesting that identifying MC based solely on UV absorbance is not valid. Our results document the discrepancy in MC concentrations that can arise by using different methods throughout all stages of sampling, analysis, and reporting of MC concentrations.

  9. A Comparison of Kernel Equating and Traditional Equipercentile Equating Methods and the Parametric Bootstrap Methods for Estimating Standard Errors in Equipercentile Equating

    ERIC Educational Resources Information Center

    Choi, Sae Il

    2009-01-01

    This study used simulation (a) to compare the kernel equating method to traditional equipercentile equating methods under the equivalent-groups (EG) design and the nonequivalent-groups with anchor test (NEAT) design and (b) to apply the parametric bootstrap method for estimating standard errors of equating. A two-parameter logistic item response…

  10. Sonic boom acceptability studies

    NASA Astrophysics Data System (ADS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; McCurdy, David A.

    1992-04-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  11. Sonic boom acceptability studies

    NASA Technical Reports Server (NTRS)

    Shepherd, Kevin P.; Sullivan, Brenda M.; Leatherwood, Jack D.; Mccurdy, David A.

    1992-01-01

    The determination of the magnitude of sonic boom exposure which would be acceptable to the general population requires, as a starting point, a method to assess and compare individual sonic booms. There is no consensus within the scientific and regulatory communities regarding an appropriate sonic boom assessment metric. Loudness, being a fundamental and well-understood attribute of human hearing was chosen as a means of comparing sonic booms of differing shapes and amplitudes. The figure illustrates the basic steps which yield a calculated value of loudness. Based upon the aircraft configuration and its operating conditions, the sonic boom pressure signature which reaches the ground is calculated. This pressure-time history is transformed to the frequency domain and converted into a one-third octave band spectrum. The essence of the loudness method is to account for the frequency response and integration characteristics of the auditory system. The result of the calculation procedure is a numerical description (perceived level, dB) which represents the loudness of the sonic boom waveform.

  12. Standardized methods for the production of high specific-activity zirconium-89.

    PubMed

    Holland, Jason P; Sheh, Yiauchung; Lewis, Jason S

    2009-10-01

    Zirconium-89 is an attractive metallo-radionuclide for use in immuno-PET due to favorable decay characteristics. Standardized methods for the routine production and isolation of high-purity and high-specific-activity (89)Zr using a small cyclotron are reported. Optimized cyclotron conditions reveal high average yields of 1.52+/-0.11 mCi/muA.h at a proton beam energy of 15 MeV and current of 15 muA using a solid, commercially available (89)Y-foil target (0.1 mm, 100% natural abundance). (89)Zr was isolated in high radionuclidic and radiochemical purity (>99.99%) as [(89)Zr]Zr-oxalate by using a solid-phase hydroxamate resin with >99.5% recovery of the radioactivity. The effective specific-activity of (89)Zr was found to be in the range 5.28-13.43 mCi/microg (470-1195 Ci/mmol) of zirconium. New methods for the facile production of [(89)Zr]Zr-chloride are reported. Radiolabeling studies using the trihydroxamate ligand desferrioxamine B (DFO) gave 100% radiochemical yields in <15 min at room temperature, and in vitro stability measurements confirmed that [(89)Zr]Zr-DFO is stable with respect to ligand dissociation in human serum for >7 days. Small-animal positron emission tomography (PET) imaging studies have demonstrated that free (89)Zr(IV) ions administered as [(89)Zr]Zr-chloride accumulate in the liver, whilst [(89)Zr]Zr-DFO is excreted rapidly via the kidneys within <20 min. These results have important implication for the analysis of immuno-PET imaging of (89)Zr-labeled monoclonal antibodies. The detailed methods described can be easily translated to other radiochemistry facilities and will facilitate the use of (89)Zr in both basic science and clinical investigations.

  13. Standardized method for solubility and storage of capsaicin-based solutions for cough induction

    PubMed Central

    2014-01-01

    Background Preparation of inhaled capsaicin solutions for cough induction varies greatly from one lab to another, which creates inconsistencies between tussigenic challenge results. The addition of Tween to these capsaicin solutions provides increased solubility and stability; however, the foul taste of Tween makes inhaling the solution for any prolonged period of time unpleasant. We sought to create a standard method for preparing soluble and stable capsaicin-based solutions (in 10% ethanol/water), without the addition of Tween. Methods Capsaicin solutions were created at concentrations ranging from 0 to 500 μM in a variety of solvent systems, with and without Tween. Samples were stored in four different environments (-20°C, 3°C, and room temperature, protected from light; and room temperature, exposed to light) to test stability. Detection of capsaicin was carried out by UV absorption. A Grubb’s test was performed on all data to remove statistical outliers. Results Similar capsaicin concentrations were seen for solutions prepared with or without Tween (Tween provided a slight increase in solubility), with neither solvent system providing complete solubility. Of the four environments tested, storing capsaicin solutions at 3°C while protected from light afforded the greatest stability, for a minimum of 30 weeks. Conclusion We recommend the use of a 10% ethanol/water solvent system without Tween in the preparation of capsaicin solutions for tussigenic challenges. While this solvent system does not provide complete solubility, we have detailed a method for capsaicin solution preparation that will account for this loss of solubility, while maintaining a solution that is Tween-free and safe for human inhalation. PMID:25342957

  14. Acceptability of BCG vaccination.

    PubMed

    Mande, R

    1977-01-01

    The acceptability of BCG vaccination varies a great deal according to the country and to the period when the vaccine is given. The incidence of complications has not always a direct influence on this acceptability, which depends, for a very large part, on the risk of tuberculosis in a given country at a given time.

  15. ATLAS ACCEPTANCE TEST

    SciTech Connect

    Cochrane, J. C. , Jr.; Parker, J. V.; Hinckley, W. B.; Hosack, K. W.; Mills, D.; Parsons, W. M.; Scudder, D. W.; Stokes, J. L.; Tabaka, L. J.; Thompson, M. C.; Wysocki, Frederick Joseph; Campbell, T. N.; Lancaster, D. L.; Tom, C. Y.

    2001-01-01

    The acceptance test program for Atlas, a 23 MJ pulsed power facility for use in the Los Alamos High Energy Density Hydrodynamics program, has been completed. Completion of this program officially releases Atlas from the construction phase and readies it for experiments. Details of the acceptance test program results and of machine capabilities for experiments will be presented.

  16. Fast high-throughput method for the determination of acidity constants by capillary electrophoresis. II. Acidic internal standards.

    PubMed

    Cabot, Joan Marc; Fuguet, Elisabet; Ràfols, Clara; Rosés, Martí

    2010-12-24

    A fast method for the determination of acidity constants by CZE has been recently developed. This method is based on the use of an internal standard of pK(a) similar to that of the analyte. In this paper we establish the reference pK(a) values of a set of 24 monoprotic neutral acids of varied structure that we propose as internal standards. These compounds cover the most usual working pH range in CZE and facilitate the selection of adequate internal standards for a given determination. The reference pK(a) values of the acids have been established by the own internal standard method, i.e. from the mobility differences between different acids of similar pK(a) in the same pH buffers. The determined pK(a) values have been contrasted to the literature pK(a) values and confirmed by determination of the pK(a) values of some acids of the set by the classical CE method. Some systematic deviations of mobilities have been observed in NaOH buffer in reference to the other used buffers, overcoming the use of NaOH in the classical CE method. However, the deviations affect in a similar degree to the test compounds and internal standards allowing thus, the use of NaOH buffer in the internal standard method. This fact demonstrates the better performance of the internal standard method over the classical method to correct mobility deviations, which together with its fastness makes it an interesting method for the routine determination of accurate pK(a) values of new pharmaceutical drugs and drug precursors.

  17. Evaluation of the acceptability of improved supplementary foods for the treatment of moderate acute malnutrition in Burkina Faso using a mixed method approach.

    PubMed

    Iuel-Brockdorf, Ann-Sophie; Draebel, Tania Aase; Ritz, Christian; Fabiansen, Christian; Cichon, Bernardette; Brix Christensen, Vibeke; Yameogo, Charles; Oummani, Rouafi; Briend, André; Michaelsen, Kim F; Ashorn, Per; Filteau, Suzanne; Friis, Henrik

    2016-04-01

    The objective of this study was to evaluate, within the context of a randomized controlled trial of product effectiveness, the acceptability of new formulations of six corn-soy blended flours (CSB) and six lipid-based nutrient supplements (LNS) with different quantities of milk and qualities of soy for the treatment of children with moderate acute malnutrition (MAM). Our study included 1546 children aged 6-23 months and involved questionnaires after one month of supplementation home visits and interviews with a sub-sample of 20 trial participants and their caretakers, and nine focus group discussion. All 12 products were well accepted in terms of organoleptic qualities and received good ratings. However, LNS were more appreciated by caretakers and children. Additionally, an effect of soy isolate was detected on child appreciation where products with high milk content also received better ratings. CSB were not consumed as readily; 33.9% (n = 257) of children receiving CSB were reported to have leftovers compared to 17.3% (n = 134) of children receiving LNS (p=<0.001). Both CSB and LNS were referred to as foods with medicinal properties and perceived as beneficial to child health. They were both reported to have high priority in the daily feeding of the child. In conclusion, there were minimal differences in acceptability of the various CSB and LNS formulations, although CSB were less readily consumed and required smaller meal volumes. Since all products were well-accepted, decisions regarding whether the more expensive products should be used for the treatment of MAM will need to be based on their effect on child nutrition, growth and health. Future supplementary feeding programs in similar contexts could furthermore consider introducing supplementary foods as a medical treatment, as this may increase adherence and decrease sharing.

  18. Development of a proposed standard method for assessing the efficacy of fresh produce sanitizers.

    PubMed

    Beuchat, L R; Harris, L J; Ward, T E; Kajs, T M

    2001-08-01

    A series of studies was done for the purpose of developing a proposed standard method to evaluate point-of-use home sanitizers for fresh produce. Preliminary experiments were done to determine the survival of Escherichia coli O157:H7, Salmonella, and Listeria monocytogenes after inoculation onto the surface of ripe tomatoes and drying for up to 24 h at 22 +/- 2 degrees C. Within 2 h, the initial population (6.88 log10 CFU/tomato) of E. coli O157:H7 was reduced by approximately 3 log10, while reductions in similar initial populations of Salmonella and L. monocytogenes were approximately 1 and 0.6 log10 CFU/tomato, respectively, after 40 min and 3 h. A pilot study evaluated treatment with 200 ppm free chlorine and a prototype Fit produce wash (Fit) for their efficacy in killing a five-serotype mixture of Salmonella or L. monocytogenes spot inoculated on tomatoes using the proposed inoculation and recovery procedures. Inoculated tomatoes were sprayed with chlorinated water, Fit, or sterile distilled water (control) and hand rubbed for 30 s. Each tomato was then placed in a plastic bag and rinsed with 200 ml of sterile water by vigorously agitating for 30 s to simulate a procedure consumers might use for sanitizing and rinsing produce in a home setting. Each tomato was transferred to a second bag, and 20 ml of sterile 0.1% peptone was added; tomatoes were rubbed by hand for 40 s. Populations of Salmonella or L. monocytogenes in the rinse water and the 0.1% peptone wash solution were determined. Treatment with 200 ppm chlorine and Fit resulted in > or = 3.07 and > 6.83 log10 reductions, respectively, in Salmonella. Treatment with 200 ppm chlorine and Fit reduced the number of L. monocytogenes by > or = 3.33 and > or = 4.96 log10 CFU/tomato, respectively. The proposed standard method for testing the efficacy of point-of-use produce sanitizers needs to be evaluated for reproducibility of results through a larger scale series of experiments.

  19. Optimization of two methods based on ultrasound energy as alternative to European standards for soluble salts extraction from building materials.

    PubMed

    Prieto-Taboada, N; Gómez-Laserna, O; Martinez-Arkarazo, I; Olazabal, M A; Madariaga, J M

    2012-11-01

    The Italian recommendation NORMAL 13/83, later replaced by the UNI 11087/2003 norm, were used as standard for soluble salts extraction from construction materials. These standards are based on long-time stirring (72 and 2h, respectively) of the sample in deionized water. In this work two ultrasound based methods were optimized in order to reduce the extraction time while efficiency is improved. The instrumental variables involved in the extraction assisted by ultrasound bath and focused ultrasounds were optimized by experimental design. As long as it was possible, the same non-instrumental parameters values as those of standard methods were used in order to compare the results obtained on a mortar sample showing a black crust by the standards and the optimized methods. The optimal extraction time for the ultrasounds bath was found to be of two hours. Although the extraction time was equal to the standard UNI 11087/2003, the obtained extraction recovery was improved up to 119%. The focused ultrasound system achieved also better recoveries (up to 106%) depending on the analyte in 1h treatment time. The repeatabilities of the proposed ultrasound based methods were comparables to those of the standards. Therefore, the selection of one or the other of the ultrasound based methods will depend on topics such as laboratory facilities or number of samples, and not in aspects related with their quality parameters.

  20. Introduction to a standardized method for the evaluation of the potency of Bacillus thuringiensis serotype H-14 based products*

    PubMed Central

    Rishikesh, N.; Quélennec, G.

    1983-01-01

    Vector resistance and other constraints have necessitated consideration of the use of alternative materials and methods in an integrated approach to vector control. Bacillus thuringiensis serotype H-14 is a promising biological control agent which acts as a conventional larvicide through its delta-endotoxin (active ingredient) and which now has to be suitably formulated for application in vector breeding habitats. The active ingredient in the formulations has so far not been chemically characterized or quantified and therefore recourse has to be taken to a bioassay method. Drawing on past experience and through the assistance mainly of various collaborating centres, the World Health Organization has standardized a bioassay method (described in the Annex), which gives consistent and reproducible results. The method permits the determination of the potency of a B.t. H-14 preparation through comparison with a standard powder. The universal adoption of the standardized bioassay method will ensure comparability of the results of different investigators. PMID:6601545

  1. Acceptance Priority Ranking & Annual Capacity Report

    SciTech Connect

    2004-07-31

    The Nuclear Waste Policy Act of 1982, as amended (the Act), assigns the Federal Government the responsibility for the disposal of spent nuclear fuel and high-level waste. Section 302(a) of the Act authorizes the Secretary to enter into contracts with the owners and generators of commercial spent nuclear fuel and/or high-level waste. The Standard Contract for Disposal of Spent Nuclear Fuel and/or High-Level Radioactive Waste (Standard Contract) established the contractual mechanism for the Department's acceptance and disposal of spent nuclear fuel and high-level waste. It includes the requirements and operational responsibilities of the parties to the Standard Contract in the areas of administrative matters, fees, terms of payment, waste acceptance criteria, and waste acceptance procedures. The Standard Contract provides for the acquisition of title to the spent nuclear fuel and/or high-level waste by the Department, its transportation to Federal facilities, and its subsequent disposal.

  2. Verification of JUPITER Standard Analysis Method for Upgrading Joyo MK-III Core Design and Management

    NASA Astrophysics Data System (ADS)

    Maeda, Shigetaka; Ito, Chikara; Sekine, Takashi; Aoyama, Takafumi

    In the experimental fast reactor Joyo, loading of irradiation test rigs causes a decrease in excess reactivity because the rigs contain less fissile materials than the driver fuel. In order to carry out duty operation cycles using as many irradiation rigs as possible, it is necessary to upgrade the core performance to increase its excess reactivity and irradiation capacity. Core modification plans have been considered, such as the installation of advanced radial reflectors and reduction of the number of control rods. To implement such core modifications, it is first necessary to improve the prediction accuracy in core design and to optimize safety margins. In the present study, verification of the JUPITER fast reactor standard analysis method was conducted through a comparison between the calculated and the measured Joyo MK-III core characteristics, and it was concluded that the accuracy for a small sodium-cooled fast reactor with a hard neutron spectrum was within 5 % of unity. It was shown that, the performance of the irradiation bed core could be upgraded by the improvement of the prediction accuracy of the core characteristics and optimization of safety margins.

  3. Standard metrics and methods for conducting Avian/wind energy interaction studies

    SciTech Connect

    Anderson, R.L.; Davis, H.; Kendall, W.

    1997-12-31

    The awareness of the problem of avian fatalities at large scale wind energy developments first emerged in the late 1980`s at the Altamont Pass Wind Resource Area (WRA) in Central California. Observations of dead raptors at the Altamont Pass WRA triggered concern on the part of regulatory agencies, environmental/conservation groups, resource agencies, and wind and electric utility industries. This led the California Energy Commission staff, along with the planning departments of Alameda, Contra Costa, and Solano counties, to commission a study of bird mortality at the Altamont Pass WRA. In addition to the Altamont Pass WRA, other studies and observations have established that windplants kill birds. Depending upon the specific factors, this may or may not be a serious problem. The current level of scrutiny and caution exhibited during the permitting of a new windplant development in the United States results in costly delays and studies. This is occurring during a highly competitive period for electrical production companies in the USA. Clarification of the bird fatality issue is needed to bring it into perspective. This means standardizing metrics, defining terms, and recommending methods to be used in addressing or studying wind energy/bird interactions.

  4. A quantitative and standardized robotic method for the evaluation of arm proprioception after stroke.

    PubMed

    Simo, Lucia S; Ghez, Claude; Botzer, Lior; Scheidt, Robert A

    2011-01-01

    Stroke often results in both motor and sensory deficits, which may interact in the manifested functional impairment. Proprioception is known to play important roles in the planning and control of limb posture and movement; however, the impact of proprioceptive deficits on motor function has been difficult to elucidate due in part to the qualitative nature of available clinical tests. We present a quantitative and standardized method for evaluating proprioception in tasks directly relevant to those used to assess motor function. Using a robotic manipulandum that exerted controlled displacements of the hand, stroke participants were evaluated, and compared with a control group, in their ability to detect such displacements in a 2-alternative, forced-choice paradigm. A psychometric function parameterized the decision process underlying the detection of the hand displacements. The shape of this function was determined by a signal detection threshold and by the variability of the response about this threshold. Our automatic procedure differentiates between participants with and without proprioceptive deficits and quantifies functional proprioceptive sensation on a magnitude scale that is meaningful for ongoing studies of degraded motor function in comparable horizontal movements.

  5. Orbiter Cold Plate Intergranular Corrosion: Development of NDE Standards and Assessment of NDE Methods

    NASA Technical Reports Server (NTRS)

    Smith, Stephen W.; Winfree, William P.; Piascik, Robert S.

    2002-01-01

    During pre-servicing of a space shuttle (orbiter vehicle, OV-102), helium leak detection of an avionics cold plate identified a leak located in the face sheet oriented towards the support shelf. Subsequent destructive examination of the leaking cold plate revealed that intergranular corrosion had penetrated the 0.017-inch thick aluminum (AA6061) face sheet. The intergranular attack (IGA) was likely caused by an aggressive crevice environment created by condensation of water vapor between the cold plate and support shelf. Face sheet susceptibility to IGA is a result of the brazing process used in the fabrication of the cold plates. Cold plate components were brazed at 1000 F followed by a slow cooling process to avoid distortion of the bonded cold plate. The slow cool process caused excessive grain boundary precipitation resulting in a material that is susceptible to IGA. The objectives of this work are as follows: (1) Develop first-of-a-kind nondestructive evaluation (NDE) standards that contain IGA identical to that found in the orbiter cold plates; and (2) Assess advanced NDE techniques for corrosion detection and recommend methods for cold plate examination. This report documents the results of work performed at Langley Research Center to fulfill these objectives.

  6. A simple and rapid method for standard preparation of gas phase extract of cigarette smoke.

    PubMed

    Higashi, Tsunehito; Mai, Yosuke; Noya, Yoichi; Horinouchi, Takahiro; Terada, Koji; Hoshi, Akimasa; Nepal, Prabha; Harada, Takuya; Horiguchi, Mika; Hatate, Chizuru; Kuge, Yuji; Miwa, Soichi

    2014-01-01

    Cigarette smoke consists of tar and gas phase: the latter is toxicologically important because it can pass through lung alveolar epithelium to enter the circulation. Here we attempt to establish a standard method for preparation of gas phase extract of cigarette smoke (CSE). CSE was prepared by continuously sucking cigarette smoke through a Cambridge filter to remove tar, followed by bubbling it into phosphate-buffered saline (PBS). An increase in dry weight of the filter was defined as tar weight. Characteristically, concentrations of CSEs were represented as virtual tar concentrations, assuming that tar on the filter was dissolved in PBS. CSEs prepared from smaller numbers of cigarettes (original tar concentrations ≤ 15 mg/ml) showed similar concentration-response curves for cytotoxicity versus virtual tar concentrations, but with CSEs from larger numbers (tar ≥ 20 mg/ml), the curves were shifted rightward. Accordingly, the cytotoxic activity was detected in PBS of the second reservoir downstream of the first one with larger numbers of cigarettes. CSEs prepared from various cigarette brands showed comparable concentration-response curves for cytotoxicity. Two types of CSEs prepared by continuous and puff smoking protocols were similar regarding concentration-response curves for cytotoxicity, pharmacology of their cytotoxicity, and concentrations of cytotoxic compounds. These data show that concentrations of CSEs expressed by virtual tar concentrations can be a reference value to normalize their cytotoxicity, irrespective of numbers of combusted cigarettes, cigarette brands and smoking protocols, if original tar concentrations are ≤15 mg/ml.

  7. ISO standardization of scaling factor method for low and intermediate level radioactive wastes generated at nuclear power plants

    SciTech Connect

    Kashiwagi, Makoto; Masui, Hideki; Denda, Yasutaka; James, David; Lantes, Bertrand; Mueller, Wolfgang; Garamszeghy, Mike; Leganes, Jose Luis; Maxeiner, Harald; Van Velzen, Leo

    2007-07-01

    Low- and intermediate-level radioactive wastes (L-ILW ) generated at nuclear power plants are disposed of in various countries. In the disposal of such wastes, it is required that the radioactivity concentrations of waste packages should be declared with respect to difficult-to-measure nuclides (DTM nuclides), such as C-14, Ni-63 and a-emitting nuclides, which are often limited to maximum values in disposal licenses, safety cases and/or regulations for maximum radioactive concentrations. To fulfill this requirement, the Scaling Factor method (SF method) has been applied in various countries as a principal method for determining the concentrations of DTM nuclides. In the SF method, the concentrations of DTM nuclides are determined by multiplying the concentrations of certain key nuclides by SF values (the determined ratios of radioactive concentration between DTM nuclides and those key nuclides). The SF values used as conversion factors are determined from the correlation between DTM nuclides and key nuclides such as Co-60. The concentrations of key nuclides are determined by {gamma} ray measurements which can be made comparatively easily from outside the waste package. The SF values are calculated based on the data obtained from the radiochemical analysis of waste samples. The use of SFs, which are empirically based on analytical data, has become established as a widely recognized 'de facto standard'. A number of countries have independently collected nuclide data by analysis over many years and each has developed its own SF method, but all the SF methods that have been adopted are similar. The project team for standardization had been organized for establishing this SF method as a 'de jure standard' in the international standardization system of the International Organization for Standardization (ISO). The project team for standardization has advanced the standardization through technical studies, based upon each country's study results and analysis data. The

  8. Standardization of Operator-Dependent Variables Affecting Precision and Accuracy of the Disk Diffusion Method for Antibiotic Susceptibility Testing.

    PubMed

    Hombach, Michael; Maurer, Florian P; Pfiffner, Tamara; Böttger, Erik C; Furrer, Reinhard

    2015-12-01

    Parameters like zone reading, inoculum density, and plate streaking influence the precision and accuracy of disk diffusion antibiotic susceptibility testing (AST). While improved reading precision has been demonstrated using automated imaging systems, standardization of the inoculum and of plate streaking have not been systematically investigated yet. This study analyzed whether photometrically controlled inoculum preparation and/or automated inoculation could further improve the standardization of disk diffusion. Suspensions of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213 of 0.5 McFarland standard were prepared by 10 operators using both visual comparison to turbidity standards and a Densichek photometer (bioMérieux), and the resulting CFU counts were determined. Furthermore, eight experienced operators each inoculated 10 Mueller-Hinton agar plates using a single 0.5 McFarland standard bacterial suspension of E. coli ATCC 25922 using regular cotton swabs, dry flocked swabs (Copan, Brescia, Italy), or an automated streaking device (BD-Kiestra, Drachten, Netherlands). The mean CFU counts obtained from 0.5 McFarland standard E. coli ATCC 25922 suspensions were significantly different for suspensions prepared by eye and by Densichek (P < 0.001). Preparation by eye resulted in counts that were closer to the CLSI/EUCAST target of 10(8) CFU/ml than those resulting from Densichek preparation. No significant differences in the standard deviations of the CFU counts were observed. The interoperator differences in standard deviations when dry flocked swabs were used decreased significantly compared to the differences when regular cotton swabs were used, whereas the mean of the standard deviations of all operators together was not significantly altered. In contrast, automated streaking significantly reduced both interoperator differences, i.e., the individual standard deviations, compared to the standard deviations for the manual method, and the mean of

  9. Standardization of Operator-Dependent Variables Affecting Precision and Accuracy of the Disk Diffusion Method for Antibiotic Susceptibility Testing.

    PubMed

    Hombach, Michael; Maurer, Florian P; Pfiffner, Tamara; Böttger, Erik C; Furrer, Reinhard

    2015-12-01

    Parameters like zone reading, inoculum density, and plate streaking influence the precision and accuracy of disk diffusion antibiotic susceptibility testing (AST). While improved reading precision has been demonstrated using automated imaging systems, standardization of the inoculum and of plate streaking have not been systematically investigated yet. This study analyzed whether photometrically controlled inoculum preparation and/or automated inoculation could further improve the standardization of disk diffusion. Suspensions of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213 of 0.5 McFarland standard were prepared by 10 operators using both visual comparison to turbidity standards and a Densichek photometer (bioMérieux), and the resulting CFU counts were determined. Furthermore, eight experienced operators each inoculated 10 Mueller-Hinton agar plates using a single 0.5 McFarland standard bacterial suspension of E. coli ATCC 25922 using regular cotton swabs, dry flocked swabs (Copan, Brescia, Italy), or an automated streaking device (BD-Kiestra, Drachten, Netherlands). The mean CFU counts obtained from 0.5 McFarland standard E. coli ATCC 25922 suspensions were significantly different for suspensions prepared by eye and by Densichek (P < 0.001). Preparation by eye resulted in counts that were closer to the CLSI/EUCAST target of 10(8) CFU/ml than those resulting from Densichek preparation. No significant differences in the standard deviations of the CFU counts were observed. The interoperator differences in standard deviations when dry flocked swabs were used decreased significantly compared to the differences when regular cotton swabs were used, whereas the mean of the standard deviations of all operators together was not significantly altered. In contrast, automated streaking significantly reduced both interoperator differences, i.e., the individual standard deviations, compared to the standard deviations for the manual method, and the mean of

  10. Determination of trace halogens in rock samples by radiochemical neutron activation analysis coupled with the k0-standardization method.

    PubMed

    Ozaki, Hiromasa; Ebihara, Mitsuru

    2007-02-01

    Radiochemical neutron activation analysis coupled with the k0-standardization method (k0-RNAA method) was applied to silicate rock samples for the simultaneous determination of trace halogens (Cl, Br and I). Analytical results obtained by the k0-RNAA method for geological standard rocks and meteorite samples agreed with those determined by the conventional comparison method conducted in the same set of experiments, suggesting that the k0-RNAA method is as reliable as the conventional method. Our data for these samples are in good agreement with their literature values except for rare cases. Detection limits calculated under the present experimental condition are sufficiently low for Cl and Br but not for I for typical geologic and meteoritic samples. The k0-RNAA method coupled with longer neutron-irradiation is expected to yield satisfactorily low detection limits for halogens including I in these samples.

  11. The Effects of Different Standard Setting Methods and the Composition of Borderline Groups: A Study within a Law Curriculum

    ERIC Educational Resources Information Center

    Dochy, Filip; Kyndt, Eva; Baeten, Marlies; Pottier, Sofie; Veestraeten, Marlies; Leuven, K. U.

    2009-01-01

    The aim of this study was to examine the effect of different standard setting methods on the size and composition of the borderline group, on the discrimination between different types of students and on the types of students passing with one method but failing with another. A total of 107 university students were classified into 4 different types…

  12. A NEW APPROACH FOR CULTURING LEMNA MINOR (DUCKWEED) AND STANDARDIZED METHOD FOR USING ATRAZINE AS A REFERENCE TOXICANT

    EPA Science Inventory

    Lemna minor (Duckweed) is commonly used in aquatic toxicity investigations. Methods for culturing and testing with reference toxicants, such as atrazine, are somewhat variable among researchers. Our goal was to develop standardized methods of culturing and testing for use with L....

  13. Condition Assessment Survey (CAS) Program. Deficiency standards and inspections methods manual: Volume 2, 0.02 Substructure

    SciTech Connect

    Not Available

    1993-05-01

    System information is given for asset determinant factor/CAS repair codes/CAS cost factors; guide sheet tool & material listing; testing methods; inspection frequency; standard system design life tables; system work breakdown structure; and general system/material data. System assembly/component deficiencies and inspection methods are given for slabs-on-grade, columns, and column fireproofing.

  14. Essential Limitations of the Standard THz TDS Method for Substance Detection and Identification and a Way of Overcoming Them

    PubMed Central

    Trofimov, Vyacheslav A.; Varentsova, Svetlana A.

    2016-01-01

    Low efficiency of the standard THz TDS method of the detection and identification of substances based on a comparison of the spectrum for the signal under investigation with a standard signal spectrum is demonstrated using the physical experiments conducted under real conditions with a thick paper bag as well as with Si-based semiconductors under laboratory conditions. In fact, standard THz spectroscopy leads to false detection of hazardous substances in neutral samples, which do not contain them. This disadvantage of the THz TDS method can be overcome by using time-dependent THz pulse spectrum analysis. For a quality assessment of the standard substance spectral features presence in the signal under analysis, one may use time-dependent integral correlation criteria. PMID:27070617

  15. Acceptance procedures: Microfilm printer

    NASA Technical Reports Server (NTRS)

    Lockwood, H. E.

    1973-01-01

    Acceptance tests were made for a special order automatic additive color microfilm printer. Tests include film capacity, film transport, resolution, illumination uniformity, exposure range checks, and color cuing considerations.

  16. A Priori Method of Using Photon Activation Analysis to Determine Unknown Trace Element Concentrations in NIST Standards

    SciTech Connect

    Green, Jaromy; Sun Zaijing; Wells, Doug; Benson, Buck; Maschner, Herb

    2009-03-10

    Photon activation analysis detected elements in two NIST standards that did not have reported concentration values. A method is currently being developed to infer these concentrations by using scaling parameters and the appropriate known quantities within the NIST standard itself. Scaling parameters include: threshold, peak and endpoint energies; photo-nuclear cross sections for specific isotopes; Bremstrahlung spectrum; target thickness; and photon flux. Photo-nuclear cross sections and energies from the unknown elements must also be known. With these quantities, the same integral was performed for both the known and unknown elements resulting in an inference of the concentration of the un-reported element based on the reported value. Since Rb and Mn were elements that were reported in the standards, and because they had well-identified peaks, they were used as the standards of inference to determine concentrations of the unreported elements of As, I, Nb, Y, and Zr. This method was tested by choosing other known elements within the standards and inferring a value based on the stated procedure. The reported value of Mn in the first NIST standard was 403{+-}15 ppm and the reported value of Ca in the second NIST standard was 87000 ppm (no reported uncertainty). The inferred concentrations were 370{+-}23 ppm and 80200{+-}8700 ppm respectively.

  17. HOLON/CADSE: integrating open software standards and formal methods to generate guideline-based decision support agents.

    PubMed Central

    Silverman, B. G.; Sokolsky, O.; Tannen, V.; Wong, A.; Lang, L.; Khoury, A.; Campbell, K.; Qiang, C.; Sahuguet, A.

    1999-01-01

    This paper describes the efforts of a consortium that is trying to develop and validate formal methods and a meta-environment for authoring, checking, and maintaining a large repository of machine executable practice guidelines. The goal is to integrate and extend a number of open software standards so that guidelines in the meta-environment become a resource that any vendor can plug their applications into and run in their proprietary environment provided they conform to the interface standards. PMID:10566502

  18. Surface microbial contamination in hospitals: A pilot study on methods of sampling and the use of proposed microbiologic standards.

    PubMed

    Claro, Tânia; O'Reilly, Marese; Daniels, Stephen; Humphreys, Hilary

    2015-09-01

    Contamination of hospital surfaces by bacteria is increasingly recognized. We assessed commonly touched surfaces using contact plates and Petrifilms (3M, St. Paul, MN) and compared the results against proposed microbiology standards. Toilet door handles were the most heavily contaminated (7.97 ± 0.68 colony forming units [CFU]/cm(2)) and exceeded proposed standards on 74% of occasions. Petrifilms detected statistically higher CFU from bedside lockers. Further research is required on the use of standards and methods of sampling.

  19. Generalized group chain acceptance sampling plan

    NASA Astrophysics Data System (ADS)

    Zain, Zakiyah; Mughal, Abdur Razzaque; Aziz, Nazrina

    2015-12-01

    In this article, we proposed an acceptance sampling plan based on generalized group chain truncated life test. The decision on acceptance of a submitted lot can be made by using the cumulative information of the immediately preceding samples. The design parameters of the proposed plan such as the minimum number of groups are found to satisfy the desired quality standard. The benefits of this plan include smaller sample size and reduced overall costs.

  20. Plasma Hazards and Acceptance for International Space Station Extravehicular Activities

    NASA Astrophysics Data System (ADS)

    Patton, Thomas

    2010-09-01

    Extravehicular activity(EVA) is accepted by NASA and other space faring agencies as a necessary risk in order to build and maintain a safe and efficient laboratory in space. EVAs are used for standard construction and as contingency operations to repair critical equipment for vehicle sustainability and safety of the entire crew in the habitable volume. There are many hazards that are assessed for even the most mundane EVA for astronauts, and the vast majority of these are adequately controlled per the rules of the International Space Station Program. The need for EVA repair and construction has driven acceptance of a possible catastrophic hazard to the EVA crewmember which cannot currently be controlled adequately. That hazard is electrical shock from the very environment in which they work. This paper describes the environment, causes and contributors to the shock of EVA crewmembers attributed to the ionospheric plasma environment in low Earth orbit. It will detail the hazard history, and acceptance process for the risk associated with these hazards that give assurance to a safe EVA. In addition to the hazard acceptance process this paper will explore other factors that go into the decision to accept a risk including criticality of task, hardware design and capability, and the probability of hazard occurrence. Also included will be the required interaction between organizations at NASA(EVA Office, Environments, Engineering, Mission Operations, Safety) in order to build and eventually gain adequate acceptance rationale for a hazard of this kind. During the course of the discussion, all current methods of mitigating the hazard will be identified. This paper will capture the history of the plasma hazard analysis and processes used by the International Space Station Program to formally assess and qualify the risk. The paper will discuss steps that have been taken to identify and perform required analysis of the floating potential shock hazard from the ISS environment

  1. Analytical Method for the Identification and Assay of Kojic Acid, Methylparaben, and Propylparaben in Cosmetic Products Using UPLC: Application of ISO 12787:2011 Standard.

    PubMed

    Qadir, Muhammad Abdul; Ahmed, Mahmood; Shafiq, Muhammad Imtiaz; Ali, Amir; Sadiq, Asma

    2016-09-01

    A straightforward, fast UPLC method is developed for the identification and quantification of kojic acid (KA), methylparaben (MP), and propylparaben (PP) in 15 cosmetic products (skin whitening creams and lotions). Chromatographic separations for KA, MP, and PP were obtained in 3.5 min on an Acquity BEH-C18 column (100 × 2.1 mm, 1.7 μm particle size) as the stationary phase at 260 nm (diode-array detector), with the mobile phase comprising a mixture of 0.01 M dibasic potassium phosphate and methanol-acetonitrile (50 + 50). Validation studies were performed according to in-house established criteria. There was a linear function of concentrations over the range of 0.4-1.6 μg/mL for KA, MP, and PP. The LOQ for all components was 0.2 μg/mL using the S/N method. Good separation of analytes was observed, with acceptable values of resolution and tailing. The analytical approach defined in the ISO 12787:2011 standard ("Cosmetics-Analytical methods-Validation criteria for analytical results using chromatographic techniques") was used for the assay of cosmetic samples. PMID:27329740

  2. Hanford Site Solid Waste Acceptance Criteria

    SciTech Connect

    Not Available

    1993-11-17

    This manual defines the Hanford Site radioactive, hazardous, and sanitary solid waste acceptance criteria. Criteria in the manual represent a guide for meeting state and federal regulations; DOE Orders; Hanford Site requirements; and other rules, regulations, guidelines, and standards as they apply to acceptance of radioactive and hazardous solid waste at the Hanford Site. It is not the intent of this manual to be all inclusive of the regulations; rather, it is intended that the manual provide the waste generator with only the requirements that waste must meet in order to be accepted at Hanford Site TSD facilities.

  3. A Conceptual Framework for a Psychometric Theory for Standard Setting with Examples of Its Use for Evaluating the Functioning of Two Standard Setting Methods

    ERIC Educational Resources Information Center

    Reckase, Mark D.

    2006-01-01

    A conceptual framework is proposed for a psychometric theory of standard setting. The framework suggests that participants in a standard setting process (panelists) develop an internal, intended standard as a result of training and the participant's background. The goal of a standard setting process is to convert panelists' intended standards to…

  4. Comparison of standard methods and gas chromatography method in determination of formaldehyde emission from MDF bonded with formaldehyde-based resins.

    PubMed

    Kim, Sumin; Kim, Hyun-Joong

    2005-09-01

    Formaldehyde emissions from MDF bonded with urea-formaldehyde resin (UF), melamine-formaldehyde resin (MF) and the co-polycondensation resin of urea-melamine-formaldehyde (UMF) and melamine-formaldehyde, measured by the Japanese standard method of determining formaldehyde emission with a desiccator (JIS A 5908) and the DIN EN 120 (European Committee For Standardization, 1991) method using the perforator value, were used as the typical standard methods. While the UF resin showed a desiccator value of 7.05 ppm and a perforator value of 12.1 mg/100 g panel, the MF resin exhibited a desiccator value of 0.6 ppm and a perforator value of 2.88 mg/100 g panel. According to the Japanese industrial standard and the European standard, the formaldehyde emission level of the MDF panels made with UF resin in this study was E(2) grade. The formaldehyde emission level was dramatically reduced by the addition of MF resin. This is because the addition of formaldehyde to melamine occurs more easily and completely than its addition to urea, even though the condensation reaction of melamine with formaldehyde is similar to that between urea and formaldehyde. These two methods, the desiccator method and the perforator method, produced proportionally equivalent results. Gas chromatography, a more sensitive and advanced method, was also used. The samples used for gas chromatography were gathered during the experiment involving the perforator method. The formaldehyde emission levels obtained from gas chromatography were similar to those obtained from the perforator method. The formaldehyde contents measured by gas chromatography were directly proportional to the perforator values.

  5. User-generated quality standards for youth mental health in primary care: a participatory research design using mixed methods

    PubMed Central

    Graham, Tanya; Rose, Diana; Murray, Joanna; Ashworth, Mark; Tylee, André

    2014-01-01

    Objectives To develop user-generated quality standards for young people with mental health problems in primary care using a participatory research model. Methods 50 young people aged 16–25 from community settings and primary care participated in focus groups and interviews about their views and experiences of seeking help for mental health problems in primary care, cofacilitated by young service users and repeated to ensure respondent validation. A second group of young people also aged 16–25 who had sought help for any mental health problem from primary care or secondary care within the last 5 years were trained as focus groups cofacilitators (n=12) developed the quality standards from the qualitative data and participated in four nominal groups (n=28). Results 46 quality standards were developed and ranked by young service users. Agreement was defined as 100% of scores within a two-point region. Group consensus existed for 16 quality standards representing the following aspects of primary care: better advertising and information (three); improved competence through mental health training and skill mix within the practice (two); alternatives to medication (three); improved referral protocol (three); and specific questions and reassurances (five). Alternatives to medication and specific questions and reassurances are aspects of quality which have not been previously reported. Conclusions We have demonstrated the feasibility of using participatory research methods in order to develop user-generated quality standards. The development of patient-generated quality standards may offer a more formal method of incorporating the views of service users into quality improvement initiatives. This method can be adapted for generating quality standards applicable to other patient groups. PMID:24920648

  6. User Acceptance of Picture Archiving and Communication System in the Emergency Department

    PubMed Central

    Goodarzi, Hassan; Khatami, Seyed-Masoud; Javadzadeh, Hammidreza; Mahmoudi, Sadrollah; Khajehpour, Hojjatollah; Heidari, Soleiman; Khodaparast, Morteza; Ebrahimi, Ali; Rasouli, Hamidreza; Ghane, Mohammadreza; Faraji, Mehrdad; Hassanpour, Kasra

    2016-01-01

    Background Picture archiving and communication system (PACS) has allowed the medical images to be transmitted, stored, retrieved, and displayed in different locations of a hospital or health system. Using PACS in the emergency department will eventually result in improved efficiency and patient care. In spite of the abundant benefits of employing PACS, there are some challenges in implementing this technology like users’ resistance to accept the technology, which has a critical role in PACS success. Objectives In this study, we will assess and compare user acceptance of PACS in the emergency departments of three different hospitals and investigate the effect of socio-demographic factors on this acceptance. Materials and Methods A variant of technology acceptance model (TAM) has been used in order to measure the acceptance level of PACS in the emergency department of three educational hospitals in Iran. A previously used questionnaire was validated and utilized to collect the study data. A stepwise multiple regression model was used to predict factors influencing acceptance score as the dependent variable. Results Mean age of participants was 32.9 years (standard deviation [SD] = 6.08). Participants with the specialty degree got a higher acceptance score than the three other groups (Mean ± SD = 4.17 ± 0.20). Age, gender, degree of PACS usage and participant’s occupation (profession) did not influence the acceptance score. In our multiple regression model, all three variables of perceived usefulness (PU), perceived ease of use (PEU) and the effect of PACS (change) had a significant effect in the prediction of acceptance. The most influencing factor was change with the beta of 0.22 (P value < 0.001). Conclusion PACS is highly accepted in all three emergency departments especially among specialists. PU, PEU and change are factors influencing PACS acceptance. Our study can be used as an evidence of PACS acceptance in emergency wards. PMID:27679692

  7. Simultaneous determination of antazoline and naphazoline by the net analyte signal standard addition method and spectrophotometric technique.

    PubMed

    Asadpour-Zeynali, Karim; Ghavami, Raoof; Esfandiari, Roghayeh; Soheili-Azad, Payam

    2010-01-01

    A novel net analyte signal standard addition method (NASSAM) was used for simultaneous determination of the drugs anthazoline and naphazoline. The NASSAM can be applied for determination of analytes in the presence of known interferents. The proposed method is used to eliminate the calibration and prediction steps of multivariate calibration methods; the determination is carried out in a single step for each analyte. The accuracy of the predictions against the H-point standard addition method is independent of the shape of the analyte and interferent spectra. The net analyte signal concept was also used to calculate multivariate analytical figures of merit, such as LOD, selectivity, and sensitivity. The method was successfully applied to the simultaneous determination of anthazoline and naphazoline in a commercial eye drop sample.

  8. Standard addition flow method for potentiometric measurements at low concentration levels: application to the determination of fluoride in food samples.

    PubMed

    Galvis-Sánchez, Andrea C; Santos, João Rodrigo; Rangel, António O S S

    2015-02-01

    A standard addition method was implemented by using a flow manifold able to perform automatically multiple standard additions and in-line sample treatment. This analytical strategy was based on the in-line mixing of sample and standard addition solutions, using a merging zone approach. The flow system aimed to exploit the standard addition method to quantify the target analyte particularly in cases where the analyte concentration in the matrix is below the lower limit of linear response of the detector. The feasibility of the proposed flow configuration was assessed through the potentiometric determination of fluoride in sea salts of different origins and different types of coffee infusions. The limit of quantification of the proposed manifold was 5×10(-6) mol L(-1), 10-fold lower than the lower limit of linear response of the potentiometric detector used. A determination rate of 8 samples h(-1) was achieved considering an experimental procedure based on three standard additions per sample. The main advantage of the proposed strategy is the simple approach to perform multiple standard additions, which can be implemented with other ion selective electrodes, especially in cases when the primary ion is below the lower limit of linear response of the detector.

  9. Feasibility and Acceptability of Global Positioning System (GPS) Methods to Study the Spatial Contexts of Substance Use and Sexual Risk Behaviors among Young Men Who Have Sex with Men in New York City: A P18 Cohort Sub-Study

    PubMed Central

    Duncan, Dustin T.; Kapadia, Farzana; Regan, Seann D.; Goedel, William C.; Levy, Michael D.; Barton, Staci C.; Friedman, Samuel R.; Halkitis, Perry N.

    2016-01-01

    Background No global positioning system (GPS) technology study has been conducted among a sample of young gay, bisexual, and other men who have sex with men (YMSM). As such, the purpose of this study was to evaluate the feasibility and acceptability of using GPS methods to understand the spatial context of substance use and sexual risk behaviors among a sample of YMSM in New York City, a high-risk population. Methods Data came from a subsample of the ongoing P18 Cohort Study (n = 75). GPS feasibility and acceptability among participants was measured with: 1) a pre- and post-survey and 2) adherence to the GPS protocol which included returning the GPS device, self-report of charging and carrying the GPS device as well as objective data analyzed from the GPS devices. Analyses of the feasibility surveys were treated as repeated measures as each participant had a pre- and post-feasibility survey. When comparing the similar GPS survey items asked at baseline and at follow-up, we present percentages and associated p-values based on chi-square statistics. Results Participants reported high ratings of pre-GPS acceptability, ease of use, and low levels of wear-related concerns in addition to few concerns related to safety, loss, or appearance, which were maintained after baseline GPS feasibility data collection. The GPS return rate was 100%. Most participants charged and carried the GPS device on most days. Of the total of 75 participants with GPS data, 75 (100%) have at least one hour of GPS data for one day and 63 (84%) had at least one hour on all 7 days. Conclusions Results from this pilot study demonstrate that utilizing GPS methods among YMSM is feasible and acceptable. GPS devices may be used in spatial epidemiology research in YMSM populations to understand place-based determinants of health such as substance use and sexual risk behaviors. PMID:26918766

  10. Apollo experience report: Acceptance checkout equipment for the Apollo spacecraft

    NASA Technical Reports Server (NTRS)

    Burtzlaff, I. J.

    1972-01-01

    The acceptance checkout equipment for the Apollo spacecraft is described, and the history of the major equipment modifications that were required to meet the Apollo Program checkout requirements is traced. Some major problem areas are outlined, and a discussion of future checkout methods is included. The concept of the future checkout methods presented provides for an increase in test equipment standardization among NASA programs and among all testing phases within a program. The capability for increased automation and reduction in the test equipment inventory is provided in the proposed concept.

  11. Standards not that standard.

    PubMed

    Vilanova, Cristina; Tanner, Kristie; Dorado-Morales, Pedro; Villaescusa, Paula; Chugani, Divya; Frías, Alba; Segredo, Ernesto; Molero, Xavier; Fritschi, Marco; Morales, Lucas; Ramón, Daniel; Peña, Carlos; Peretó, Juli; Porcar, Manuel

    2015-01-01

    There is a general assent on the key role of standards in Synthetic Biology. In two consecutive letters to this journal, suggestions on the assembly methods for the Registry of standard biological parts have been described. We fully agree with those authors on the need of a more flexible building strategy and we highlight in the present work two major functional challenges standardization efforts have to deal with: the need of both universal and orthogonal behaviors. We provide experimental data that clearly indicate that such engineering requirements should not be taken for granted in Synthetic Biology. PMID:26435739

  12. Methods for preparing comparative standards and field samples for neutron activation analysis of soil

    SciTech Connect

    Glasgow, D.C.; Dyer, F.F.; Robinson, L.

    1994-06-01

    One of the more difficult problems associated with comparative neutron activation analysis (CNAA) is the preparation of standards which are tailor-made to the desired irradiation and counting conditions. Frequently, there simply is not a suitable standard available commercially, or the resulting gamma spectrum is convoluted with interferences. In a recent soil analysis project, the need arose for standards which contained about 35 elements. In response, a computer spreadsheet was developed to calculate the appropriate amount of each element so that the resulting gamma spectrum is relatively free of interferences. Incorporated in the program are options for calculating all of the irradiation and counting parameters including activity produced, necessary flux/bombardment time, counting time, and appropriate source-to-detector distance. The result is multi-element standards for CNAA which have optimal concentrations. The program retains ease of use without sacrificing capability. In addition to optimized standard production, a novel soil homogenization technique was developed which is a low cost, highly efficient alternative to commercially available homogenization systems. Comparative neutron activation analysis for large scale projects has been made easier through these advancements. This paper contains details of the design and function of the NAA spreadsheet and innovative sample handling techniques.

  13. Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra.

    PubMed

    De Meyer, Tim; Sinnaeve, Davy; Van Gasse, Bjorn; Rietzschel, Ernst-R; De Buyzere, Marc L; Langlois, Michel R; Bekaert, Sofie; Martins, José C; Van Criekinge, Wim

    2010-10-01

    Proton nuclear magnetic resonance ((1)H-NMR)-based metabolomics enables the high-resolution and high-throughput assessment of a broad spectrum of metabolites in biofluids. Despite the straightforward character of the experimental methodology, the analysis of spectral profiles is rather complex, particularly due to the requirement of numerous data preprocessing steps. Here, we evaluate how several of the most common preprocessing procedures affect the subsequent univariate analyses of blood serum spectra, with a particular focus on how the standard methods perform compared to more advanced examples. Carr-Purcell-Meiboom-Gill 1D (1)H spectra were obtained for 240 serum samples from healthy subjects of the Asklepios study. We studied the impact of different preprocessing steps--integral (standard method) and probabilistic quotient normalization; no, equidistant (standard), and adaptive-intelligent binning; mean (standard) and maximum bin intensity data summation--on the resonance intensities of three different types of metabolites: triglycerides, glucose, and creatinine. The effects were evaluated by correlating the differently preprocessed NMR data with the independently measured metabolite concentrations. The analyses revealed that the standard methods performed inferiorly and that a combination of probabilistic quotient normalization after adaptive-intelligent binning and maximum intensity variable definition yielded the best overall results (triglycerides, R = 0.98; glucose, R = 0.76; creatinine, R = 0.70). Therefore, at least in the case of serum metabolomics, these or equivalent methods should be preferred above the standard preprocessing methods, particularly for univariate analyses. Additional optimization of the normalization procedure might further improve the analyses.

  14. A theoretical drought classification method for the multivariate drought index based on distribution properties of standardized drought indices

    NASA Astrophysics Data System (ADS)

    Hao, Zengchao; Hao, Fanghua; Singh, Vijay P.; Xia, Youlong; Ouyang, Wei; Shen, Xinyi

    2016-06-01

    Drought indices have been commonly used to characterize different properties of drought and the need to combine multiple drought indices for accurate drought monitoring has been well recognized. Based on linear combinations of multiple drought indices, a variety of multivariate drought indices have recently been developed for comprehensive drought monitoring to integrate drought information from various sources. For operational drought management, it is generally required to determine thresholds of drought severity for drought classification to trigger a mitigation response during a drought event to aid stakeholders and policy makers in decision making. Though the classification of drought categories based on the univariate drought indices has been well studied, drought classification method for the multivariate drought index has been less explored mainly due to the lack of information about its distribution property. In this study, a theoretical drought classification method is proposed for the multivariate drought index, based on a linear combination of multiple indices. Based on the distribution property of the standardized drought index, a theoretical distribution of the linear combined index (LDI) is derived, which can be used for classifying drought with the percentile approach. Application of the proposed method for drought classification of LDI, based on standardized precipitation index (SPI), standardized soil moisture index (SSI), and standardized runoff index (SRI) is illustrated with climate division data from California, United States. Results from comparison with the empirical methods show a satisfactory performance of the proposed method for drought classification.

  15. Use of lignin extracted from different plant sources as standards in the spectrophotometric acetyl bromide lignin method.

    PubMed

    Fukushima, Romualdo S; Kerley, Monty S

    2011-04-27

    A nongravimetric acetyl bromide lignin (ABL) method was evaluated to quantify lignin concentration in a variety of plant materials. The traditional approach to lignin quantification required extraction of lignin with acidic dioxane and its isolation from each plant sample to construct a standard curve via spectrophotometric analysis. Lignin concentration was then measured in pre-extracted plant cell walls. However, this presented a methodological complexity because extraction and isolation procedures are lengthy and tedious, particularly if there are many samples involved. This work was targeted to simplify lignin quantification. Our hypothesis was that any lignin, regardless of its botanical origin, could be used to construct a standard curve for the purpose of determining lignin concentration in a variety of plants. To test our hypothesis, lignins were isolated from a range of diverse plants and, along with three commercial lignins, standard curves were built and compared among them. Slopes and intercepts derived from these standard curves were close enough to allow utilization of a mean extinction coefficient in the regression equation to estimate lignin concentration in any plant, independent of its botanical origin. Lignin quantification by use of a common regression equation obviates the steps of lignin extraction, isolation, and standard curve construction, which substantially expedites the ABL method. Acetyl bromide lignin method is a fast, convenient analytical procedure that may routinely be used to quantify lignin.

  16. Development of standard measurement chain for full-field optical strain measurement methods

    NASA Astrophysics Data System (ADS)

    Salbut, Leszek; Kujawinska, Malgorzata; Patterson, Eann; Hack, Erwin; Burguete, Richard; Whelan, Maurice P.; Mendels, David A.

    2004-08-01

    Optical techniques for full-field displacement/strain measurement are a powerful set of tools for use in defining the performance, design optimization, reliability and safety of various types of components, products and machines. The quality of the measurement data generated by optical techniques is strongly dependent on the instrumentation and procedures. Thus, there is a significant need to develop standardized tests that are applicable across the spectrum of optical techniques of strain measurement. This requires the description of a common standard measurement chain including: (1) definition of standard physical and virtual materials; (2) gathering experimental or simulated primary data (fringe/image map); (3) deconvolution phase maps from these data (numerical procedures); (4) calculation of required physical quantities from phase maps (numerical procedures including data scaling). This scheme supports a calibration process for both instrumentation and procedures. Validation of this general methodology was performed using an example of displacement data gathered by grating interferometry followed by data processing scheme.

  17. IMPLEMENTING THE STANDARD SPECTRUM METHOD FOR ANALYSIS OF β-γ COINCIDENCE SPECTRA

    SciTech Connect

    Biegalski, S.; Flory, Adam E.; Schrom, Brian T.; Ely, James H.; Haas, Derek A.; Bowyer, Ted W.; Hayes, James C.

    2011-09-14

    The standard deconvolution analysis tool (SDAT) algorithms were developed and tested at the University of Texas at Austin. These algorithms utilize the standard spectrum technique for spectral analysis of {beta}-{gamma} coincidence spectra for nuclear explosion monitoring. Work has been conducted under this contract to implement these algorithms into a useable scientific software package with a graphical user interface. Improvements include the ability to read in PHD formatted data, gain matching, and data visualization. New auto-calibration algorithms were developed and implemented based on 137Cs spectra for assessment of the energy vs. channel calibrations. Details on the user tool and testing are included.

  18. Considerations on the European Standard EN 14157 Test Methods: Abrasion Resistance of Natural Stones Used for Flooring in Buildings

    NASA Astrophysics Data System (ADS)

    Karaca, Z.; Günes Yılmaz, N.; Goktan, R. M.

    2012-01-01

    In Europe, the Wide Wheel abrasion (WWA) test and the Böhme abrasion (BA) test are among the most widely used standard test methods for determining abrasion resistance of natural stones, the former being the reference test method in EN 14157 Standard. However, it is stated in the Annex-A (Informative) of EN 14157 Standard that very limited data are available to provide correlations between these two test methods. To be able to fill this gap, in this study, 25 different natural stones belonging to sedimentary, metamorphic and igneous groups were tested for their abrasion resistance as well as physico-mechanical properties. Also, for a better interpretation of abrasion resistance characteristics of the tested stone materials, relationships between abrasion resistance and physico-mechanical properties were statistically examined. A statistically significant linear correlation ( R 2 = 0.85; P value = 0.000) was established between the WWA test and the BA test, which could be used in practice for converting the measured abrasion resistance values from one testing method to another. It was also found that the correlation between these two test methods improved significantly ( R 2 = 0.93; P value = 0.001) when relatively high-porosity stone materials (porosity ≥1%) were separately evaluated. Both methods of abrasion resistance employed in the present study showed statistically significant linear correlations with uniaxial compressive strength and Brazilian tensile strength, the former proving to be a more influencing parameter on resistance to abrasion. Also, from the point view of representing actual abrasion mechanism of stone materials in practice, the necessity of simulating multi-directional foot traffic in abrasion testing methods was discussed. In this respect, the reference test method in the EN 14157 Standard was criticized for not fully meeting this requirement. It was also pointed out that the reference method could have some drawbacks when applied to coarse

  19. The development and application of k0-standardization method of neutron activation analysis at Es-Salam research reactor

    NASA Astrophysics Data System (ADS)

    Alghem, L.; Ramdhane, M.; Khaled, S.; Akhal, T.

    2006-01-01

    In recent years the k0-NAA method has been applied and developed at the 15 MW Es-Salam research reactor, which includes: (1) the detection efficiency calibration of γ-spectrometer used in k0-NAA, (2) the determination of reactor neutron spectrum parameters such as α and f factors in the irradiation channel, and (3) the validation of the developed k0-NAA procedure by analysing SRM, namely AIEA-Soil7 and CRM, namely IGGE-GSV4. The analysis results obtained by k0-NAA with 27 elements of Soil-7 standard and 14 elements of GSV-4 standard were compared with certified values. The analysis results showed that the deviations between experimental and certified values were mostly less than 10%. The k0-NAA procedure established at Es-Salam research reactor has been regarded as a reliable standardization method of NAA and as available for practical applications.

  20. Comparative study of some robust statistical methods: weighted, parametric, and nonparametric linear regression of HPLC convoluted peak responses using internal standard method in drug bioavailability studies.

    PubMed

    Korany, Mohamed A; Maher, Hadir M; Galal, Shereen M; Ragab, Marwa A A

    2013-05-01

    This manuscript discusses the application and the comparison between three statistical regression methods for handling data: parametric, nonparametric, and weighted regression (WR). These data were obtained from different chemometric methods applied to the high-performance liquid chromatography response data using the internal standard method. This was performed on a model drug Acyclovir which was analyzed in human plasma with the use of ganciclovir as internal standard. In vivo study was also performed. Derivative treatment of chromatographic response ratio data was followed by convolution of the resulting derivative curves using 8-points sin x i polynomials (discrete Fourier functions). This work studies and also compares the application of WR method and Theil's method, a nonparametric regression (NPR) method with the least squares parametric regression (LSPR) method, which is considered the de facto standard method used for regression. When the assumption of homoscedasticity is not met for analytical data, a simple and effective way to counteract the great influence of the high concentrations on the fitted regression line is to use WR method. WR was found to be superior to the method of LSPR as the former assumes that the y-direction error in the calibration curve will increase as x increases. Theil's NPR method was also found to be superior to the method of LSPR as the former assumes that errors could occur in both x- and y-directions and that might not be normally distributed. Most of the results showed a significant improvement in the precision and accuracy on applying WR and NPR methods relative to LSPR.

  1. Early Identification of ADHD: Methods, Benefits, and a Standard Performance Metric for School Districts

    ERIC Educational Resources Information Center

    Kern, Donald J.

    2011-01-01

    This dissertation as an executive position paper (EPP) will provide a thorough literature review and the most current and reliable data on Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) prevalence, show the high importance of early diagnosis and interventions, and provide a standard for a school district to…

  2. Teacher Training in Norm Setting Approaches to Drug Education: A Pilot Study Comparing Standard and Video-Enhanced Methods

    ERIC Educational Resources Information Center

    Dusenbury, Linda A.; Hansen, William B.; Giles, Steven M.

    2003-01-01

    Norm setting has been shown to be a crucial element of effective drug education. The purpose of this study was to examine the degree to which a videotape describing concepts and methods for establishing positive norms would enhance standard training. Participants included 35 teachers and 64 health education students who were randomly assigned to…

  3. Comprehensive combinatory standard correction: a calibration method for handling instrumental drifts of gas chromatography-mass spectrometry systems.

    PubMed

    Deport, Coralie; Ratel, Jérémy; Berdagué, Jean-Louis; Engel, Erwan

    2006-05-26

    The current work describes a new method, the comprehensive combinatory standard correction (CCSC), for the correction of instrumental signal drifts in GC-MS systems. The method consists in analyzing together with the products of interest a mixture of n selected internal standards, and in normalizing the peak area of each analyte by the sum of standard areas and then, select among the summation operator sigma(p = 1)(n)C(n)p possible sums, the sum that enables the best product discrimination. The CCSC method was compared with classical techniques of data pre-processing like internal normalization (IN) or single standard correction (SSC) on their ability to correct raw data from the main drifts occurring in a dynamic headspace-gas chromatography-mass spectrometry system. Three edible oils with closely similar compositions in volatile compounds were analysed using a device which performance was modulated by using new or used dynamic headspace traps and GC-columns, and by modifying the tuning of the mass spectrometer. According to one-way ANOVA, the CCSC method increased the number of analytes discriminating the products (31 after CCSC versus 25 with raw data or after IN and 26 after SSC). Moreover, CCSC enabled a satisfactory discrimination of the products irrespective of the drifts. In a factorial discriminant analysis, 100% of the samples (n = 121) were well-classified after CCSC versus 45% for raw data, 90 and 93%, respectively after IN and SSC. PMID:16631179

  4. Transitioning to the Common Core State Standards for Mathematics: A Mixed Methods Study of Elementary Teachers' Experiences and Perspectives

    ERIC Educational Resources Information Center

    Swars, Susan Lee; Chestnutt, Cliff

    2016-01-01

    This mixed methods study explored elementary teachers' (n = 73) experiences with and perspectives on the recently implemented Common Core State Standards for Mathematics (CCSS-Mathematics) at a high-needs, urban school. Analysis of the survey, questionnaire, and interview data reveals the findings cluster around: familiarity with and preparation…

  5. Linear model correction: A method for transferring a near-infrared multivariate calibration model without standard samples.

    PubMed

    Liu, Yan; Cai, Wensheng; Shao, Xueguang

    2016-12-01

    Calibration transfer is essential for practical applications of near infrared (NIR) spectroscopy because the measurements of the spectra may be performed on different instruments and the difference between the instruments must be corrected. For most of calibration transfer methods, standard samples are necessary to construct the transfer model using the spectra of the samples measured on two instruments, named as master and slave instrument, respectively. In this work, a method named as linear model correction (LMC) is proposed for calibration transfer without standard samples. The method is based on the fact that, for the samples with similar physical and chemical properties, the spectra measured on different instruments are linearly correlated. The fact makes the coefficients of the linear models constructed by the spectra measured on different instruments are similar in profile. Therefore, by using the constrained optimization method, the coefficients of the master model can be transferred into that of the slave model with a few spectra measured on slave instrument. Two NIR datasets of corn and plant leaf samples measured with different instruments are used to test the performance of the method. The results show that, for both the datasets, the spectra can be correctly predicted using the transferred partial least squares (PLS) models. Because standard samples are not necessary in the method, it may be more useful in practical uses. PMID:27380302

  6. Methods to Standardize a Multicenter Acupuncture Trial Protocol to Reduce Aromatase Inhibitor-related Joint Symptoms in Breast Cancer Patients

    PubMed Central

    Greenlee, Heather; Crew, Katherine D.; Capodice, Jillian; Awad, Danielle; Jeffres, Anne; Unger, Joseph M.; Lew, Danika L.; Hansen, Lisa K.; Meyskens, Frank L.; Wade, James L.; Hershman, Dawn L.

    2015-01-01

    Robust methods are needed to efficiently conduct large, multi-site, randomized controlled clinical trials of acupuncture protocols. SWOG S1200 is a randomized, controlled sham- and waitlist-controlled trial of a standardized acupuncture protocol treating aromatase inhibitor (AI)-associated arthralgias in early stage breast cancer patients (n=228). The primary objective is to determine whether true acupuncture administered twice weekly for 6 weeks compared to sham acupuncture or a waitlist control causes a reduction in AI-associated joint pain at 6 weeks as assessed by patient report. The study is conducted at 11 institutions across the US. The true acupuncture protocol was developed using a consensus-based process. Both the true acupuncture and sham acupuncture protocols consist of 12 sessions administered over 6 weeks, followed by 1 session per week for the remaining 6 weeks. The true acupuncture protocol uses standardized protocol points in addition to standardized acupoints tailored to a patient’s joint symptoms. The similarly standardized sham acupuncture protocol utilizes superficial needling of non-acupoints. Standardized methods were developed to train and monitor acupuncturists, including online and in-person training, study manuals, monthly phone calls, and remote quality assurance monitoring throughout the study period. Research staff was similarly trained using online and in-person training, and monthly phone calls. PMID:26100070

  7. Smaller hospitals accept advertising.

    PubMed

    Mackesy, R

    1988-07-01

    Administrators at small- and medium-sized hospitals gradually have accepted the role of marketing in their organizations, albeit at a much slower rate than larger institutions. This update of a 1983 survey tracks the increasing competitiveness, complexity and specialization of providing health care and of advertising a small hospital's services. PMID:10288550

  8. Students Accepted on Probation.

    ERIC Educational Resources Information Center

    Lorberbaum, Caroline S.

    This report is a justification of the Dalton Junior College admissions policy designed to help students who had had academic and/or social difficulties at other schools. These students were accepted on probation, their problems carefully analyzed, and much effort devoted to those with low academic potential. They received extensive academic and…

  9. Why was Relativity Accepted?

    NASA Astrophysics Data System (ADS)

    Brush, S. G.

    Historians of science have published many studies of the reception of Einstein's special and general theories of relativity. Based on a review of these studies, and my own research on the role of the light-bending prediction in the reception of general relativity, I discuss the role of three kinds of reasons for accepting relativity (1) empirical predictions and explanations; (2) social-psychological factors; and (3) aesthetic-mathematical factors. According to the historical studies, acceptance was a three-stage process. First, a few leading scientists adopted the special theory for aesthetic-mathematical reasons. In the second stage, their enthusiastic advocacy persuaded other scientists to work on the theory and apply it to problems currently of interest in atomic physics. The special theory was accepted by many German physicists by 1910 and had begun to attract some interest in other countries. In the third stage, the confirmation of Einstein's light-bending prediction attracted much public attention and forced all physicists to take the general theory of relativity seriously. In addition to light-bending, the explanation of the advance of Mercury's perihelion was considered strong evidence by theoretical physicists. The American astronomers who conducted successful tests of general relativity became defenders of the theory. There is little evidence that relativity was `socially constructed' but its initial acceptance was facilitated by the prestige and resources of its advocates.

  10. [High Throughput Screening Analysis of Preservatives and Sweeteners in Carbonated Beverages Based on Improved Standard Addition Method].

    PubMed

    Wang, Su-fang; Liu, Yun; Gong, Li-hua; Dong, Chun-hong; Fu, De-xue; Wang, Guo-qing

    2016-02-01

    Simulated water samples of 3 kinds of preservatives and 4 kinds of sweeteners were formulated by using orthogonal design. Kernel independent component analysis (KICA) was used to process the UV spectra of the simulated water samples and the beverages added different amounts of the additive standards, then the independent components (ICs), i. e. the UV spectral profiles of the additives, and the ICs' coefficient matrices were used to establish UV-KICA-SVR prediction model of the simulated preservatives and sweeteners solutions using support vector regression (SVR) analysis. The standards added beverages samples were obtained by adding different amounts level of additives in carbonated beverages, their UV spectra were processed by KICA, then IC information represented to the additives and other sample matrix were obtained, and the sample background can be deducted by removing the corresponding IC, other ICs' coefficient matrices were used to estimate the amounts of the additives in the standard added beverage samples based on the UV-KICA-SVR model, while the intercept of linear regression equation of predicted amounts and the added amounts in the standard added samples is the additive content in the raw beverage sample. By utilization of chemometric "blind source separation" method for extracting IC information of the tested additives in the beverage and other sample matrix, and using SVR regression modeling to improve the traditional standard addition method, a new method was proposed for the screening of the preservatives and sweeteners in carbonated beverages. The proposed UV-KICA-SVR method can be used to determine 3 kinds of preservatives and 4 kinds of sweetener in the carbonate beverages with the limit of detection (LOD) are located with the range 0.2-1.0 mg · L⁻¹, which are comparable to that of the traditional high performance liquid chromatographic (HPLC) method. PMID:27209754

  11. [High Throughput Screening Analysis of Preservatives and Sweeteners in Carbonated Beverages Based on Improved Standard Addition Method].

    PubMed

    Wang, Su-fang; Liu, Yun; Gong, Li-hua; Dong, Chun-hong; Fu, De-xue; Wang, Guo-qing

    2016-02-01

    Simulated water samples of 3 kinds of preservatives and 4 kinds of sweeteners were formulated by using orthogonal design. Kernel independent component analysis (KICA) was used to process the UV spectra of the simulated water samples and the beverages added different amounts of the additive standards, then the independent components (ICs), i. e. the UV spectral profiles of the additives, and the ICs' coefficient matrices were used to establish UV-KICA-SVR prediction model of the simulated preservatives and sweeteners solutions using support vector regression (SVR) analysis. The standards added beverages samples were obtained by adding different amounts level of additives in carbonated beverages, their UV spectra were processed by KICA, then IC information represented to the additives and other sample matrix were obtained, and the sample background can be deducted by removing the corresponding IC, other ICs' coefficient matrices were used to estimate the amounts of the additives in the standard added beverage samples based on the UV-KICA-SVR model, while the intercept of linear regression equation of predicted amounts and the added amounts in the standard added samples is the additive content in the raw beverage sample. By utilization of chemometric "blind source separation" method for extracting IC information of the tested additives in the beverage and other sample matrix, and using SVR regression modeling to improve the traditional standard addition method, a new method was proposed for the screening of the preservatives and sweeteners in carbonated beverages. The proposed UV-KICA-SVR method can be used to determine 3 kinds of preservatives and 4 kinds of sweetener in the carbonate beverages with the limit of detection (LOD) are located with the range 0.2-1.0 mg · L⁻¹, which are comparable to that of the traditional high performance liquid chromatographic (HPLC) method.

  12. Alternative methods of optical diagnostics in the field of standardization and metrology

    NASA Astrophysics Data System (ADS)

    Constantinov, Boris I.; Pasechnic, Teodosie I.; Sircu, Sergiu

    2000-10-01

    An optical configuration based on the photothermoplastic recording (PTPR) is suggested for the operational optical diagnostics and standardization of the products in the real time scale. The presence of three or four PTPR cameras along the counter of the tested product makes it possible to investigate in the real-time scale not only the appearance of the internal defects, but also the influence of the condition of different units onto the condition of the whole system. Dry development of the images in the real-time scale and instant fixation of images on the photothermoplastic carriers (PTPC) followed by the computer analysis used to compare the product and the standard allow us to gain in time and areas.

  13. Developing qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials.

    PubMed

    Lowenthal, Mark S; Phillips, Melissa M; Rimmer, Catherine A; Rudnick, Paul A; Simón-Manso, Yamil; Stein, Stephen E; Tchekhovskoi, Dmitrii; Phinney, Karen W

    2013-05-01

    Standard Reference Materials (SRMs) offer the scientific community a stable and homogenous source of material that holds countless application possibilities. Traditionally, the National Institute of Standards and Technology (NIST) has provided SRMs with associated quantitative information (certified values) for a select group of targeted analytes as measured in a solution or complex matrix. While the current needs of the SRM community are expanding to include non-quantitative data, NIST is attempting to broaden the scope of how and what information is offered to the SRM community by providing qualitative information about biomaterials, such as chromatographic fingerprints and profiles of untargeted identifications. In this work, metabolomic and proteomic profiling efforts were employed to characterize a suite of six Vaccinium berry SRMs. In the discovery phase, liquid chromatography-tandem mass spectrometry (LC-MS/MS) data was matched to mass spectral libraries; a subsequent validation phase based on multiple-reaction monitoring LC-MS/MS relied on both retention time matching of authentic standards along with fragmentation data for a qualitative overview of the most prominent organic compounds present. Definitive and putative identifications were determined for over 70 metabolites based on reporting guidelines set forth by the Metabolomics Standards Initiative (Metabolomics 3(3):211-221, 2007), and the capability of electrospray ionization mass spectrometry (ESI-MS) to profile untargeted metabolites within a complex matrix using mass spectral matching is demonstrated. Bottom-up proteomic analyses were possible using peptide databases translated from expressed sequence tags (ESTs). Homology searches provided identification of novel Vaccinium proteins based on homology to related genera. Chromatographic fingerprints of these berry materials were acquired for supplemental qualitative information to be provided to users of these SRMs. An unbounded set of qualitative

  14. An empirical bayes method for comparing air pollution data to air quality standards

    NASA Astrophysics Data System (ADS)

    Suggs, Jack C.; Curran, Thomas C.

    Air pollution concentrations are often characterized by skewed distributions. For example, 24-h suspended particulate mass concentrations have historically been characterized by a 2-parameter lognormal distribution (Larsen, 1969, J. Air. Pollut. Control. Ass.19, 24-30). The error in making measurements of these concentrations also conforms to a distribution that is more symmetric and can usually be approximated by the normal distribution, often with the added feature that the error variation is a function of concentration level. Air pollution measurements are often used to determine status with respect to legal standards such as the National Ambient Air Quality Standards (NAAQS) (Fed. Reg. 36, 8186, 1971; 44, 8202, 1979). In general, these standards do not explicitly account for measurement error. Using Bayesian mathematics, a model is developed which deals with the probability of the "true" concentration exceeding the NAAQS given a measurement above the NAAQS. Several hypothetical examples are used to demonstrate that Bayesian techniques can combine both pollution history and instrument precision into a probablistic model for comparing air pollution data to NAAQS.

  15. A Body of Work Standard-Setting Method with Construct Maps

    ERIC Educational Resources Information Center

    Wyse, Adam E.; Bunch, Michael B.; Deville, Craig; Viger, Steven G.

    2014-01-01

    This article describes a novel variation of the Body of Work method that uses construct maps to overcome problems of transparency, rater inconsistency, and scores gaps commonly occurring with the Body of Work method. The Body of Work method with construct maps was implemented to set cut-scores for two separate K-12 assessment programs in a large…

  16. EVALUATION OF A CRYPTOSPORIDIUM INTERNAL STANDARD FOR DETERMINING RECOVERY WITH ENVIRONMENTAL PROTECTION AGENCY METHOD 1623

    EPA Science Inventory

    The current benchmark method for detecting Cryptosporidium oocysts in water is the U.S. Environmental Protection Agency (U.S. EPA) Method 1623. Studies evaluating this method report that recoveries are highly variable and dependent upon laboratory, water sample, and analyst. Ther...

  17. Assessment of safety against derailment using simulations and vehicle acceptance tests: a worldwide comparison of state-of-the-art assessment methods

    NASA Astrophysics Data System (ADS)

    Wilson, Nicholas; Fries, Robert; Witte, Matthew; Haigermoser, Andreas; Wrang, Mikael; Evans, Jerry; Orlova, Anna

    2011-07-01

    The assessment of derailment safety of new railway vehicle designs is a fundamental concern worldwide. Although the methods used for assessment in different countries and regions vary considerably, the fundamental mechanisms being addressed are the same. This paper provides a detailed review of the current state-of-the-art methods for derailment safety assessment in several regions and countries including Europe, UK, USA, and Russia. Brief overviews of the methods used in China, Korea, and Japan are also included. Similarities and differences are discussed, including testing and computer simulations. References are provided for the origins of the methods and safety performance criteria used in each region. Recommendations are made for improving the assessment methods, especially the use and validation of computer simulations.

  18. Retrospective Conversion: A Question of Time, Standards, and Purpose.

    ERIC Educational Resources Information Center

    Valentine, Phyllis A.; McDonald, David R.

    1986-01-01

    Examines the factors that determine the cost of retrospective conversion (definition of conversion, standards of acceptance, method of conversion, hit rate, standards for creation of machine-readable records for nonhits); reports results of cost study at University of Michigan library; and introduces an alternative strategy for discussion. Seven…

  19. A Comparison of pical Root Resorption in Incisors after Fixed Orthodontic Treatment with Standard Edgewise and Straight Wire (MBT) Method

    PubMed Central

    Zahed Zahedani, SM; Oshagh, M; Momeni Danaei, Sh; Roeinpeikar, SMM

    2013-01-01

    Statement of Problem: One of the major outcomes of orthodontic treatment is the apical root resorption of teeth moved during the treatment. Identifying the possible risk factors, are necessary for every orthodontist. Purpose: The aim of this study was to compare the rate of apical root resorption after fixed orthodontic treatment with standard edgewise and straight wire (MBT) method, and also to evaluate other factors effecting the rate of root resorption in orthodontic treatments. Materials and Method: In this study, parallel periapical radiographs of 127 patients imaging a total of 737 individual teeth, were collected. A total of 76 patients were treated by standard edgewise and 51 patients by straight wire method. The periapical radiographs were scanned and then the percentage of root resorption was calculated by Photoshop software. The data were analyzed by Paired-Samples t-test and the Generalized Linear Model adopting the SPSS 15.0. Results: In patients treated with straight wire method (MBT), mean root resorption was 18.26% compared to 14.82% in patients treated with standard edgewise technique (p< .05). Male patients had higher rate of root resorption,statistically significant (p< .05). Age at onset of treatment, duration of treatment, type of dental occlusion, premolar extractions and the use of intermaxillary elastics had no significant effect on the root resorption in this study. Conclusion: Having more root resorption in the straight wire method and less in the standard edgewise technique can be attributed to more root movement in pre-adjusted MBT technique due to the brackets employed in this method. PMID:24724131

  20. Internal quality audit and quality standards as a method of quality improvement at the Department of Ophthalmology, University Hospital.

    PubMed

    Nasić, Mirjana; Pokupec, Rajko; Katusić, Damir; Miklić, Pavle; Suić, Ivan; Galić, Slobodan

    2005-01-01

    Quality assessment of clinical health care with the programme of quality standard is a method of health management, through which better efficiency and safety of health outcomes can be achieved. In the period from 2002 to 2004, a pilot program of quality has been carried out on the Department of Ophthalmology, University Hospital Center in Zagreb. Seven internal audit teams of hospital commission and teams of hospital departments were evaluating introducing practice for quality standards every three months. In the period of two years improvement in all standards of quality has been noticed (expressed in percent of progress towards the ideal result of 100%): personnel 20%, patient rights 15%, medical equipment 40%, quality of emergency service 60%, implementation of clinical guidelines and criteria for elective admission 55%, quality of risk prevention 70%, quality of medical records 60%. The two-years-improvement dynamics of about 46%, first year 24%.

  1. Acceptability of a Community-Based Outreach HIV-Testing Intervention Using Oral Fluid Collection Devices and Web-Based HIV Test Result Collection Among Sub-Saharan African Migrants: A Mixed-Method Study

    PubMed Central

    Manirankunda, Lazare; Platteau, Tom; Albers, Laura; Fransen, Katrien; Vermoesen, Tine; Namanya, Fiona; Nöstlinger, Christiana

    2016-01-01

    Background Late human immunodeficiency virus (HIV) diagnosis is common among sub-Saharan African migrants. To address their barriers to HIV testing uptake and improve timely HIV diagnoses and linkage to care, the outreach HIV testing intervention, “swab2know,” was developed. It combined a community-based approach with innovative testing methods: oral fluid self-sampling and the choice between Web-based HIV test result collections using a secured website or post-test counseling at a sexual health clinic. The sessions included an informational speech delivered by a physician of sub-Saharan African origin and testimonies by community members living with HIV. Objectives The objectives of this study were to evaluate the intervention’s acceptability among sub-Saharan African migrants and its potential to reach subgroups at higher risk for HIV infection and to identify facilitators and barriers for HIV testing uptake. Methods This mixed-method study combined qualitative (participant observations and informal interviews with testers and nontesters) and quantitative data (paper–pencil survey, laboratory data, and result collection files). Data were analyzed using a content analytical approach for qualitative and univariate analysis for quantitative data. Results A total of 10 testing sessions were organized in sub-Saharan African migrant community venues in the city of Antwerp, Belgium, between December 2012 and June 2013. Overall, 18.2% of all people present (N=780) underwent HIV testing; 29.8% of them tested for HIV for the first time, 22.3% did not have a general practitioner, and 21.5% reported 2 or more sexual partners (last 3 months). Overall, 56.3% of participants chose to collect their HIV test results via the protected website. In total, 78.9% collected their results. The qualitative analysis of 137 participant observation field notes showed that personal needs and Internet literacy determined the choice of result collection method. Generally, the oral

  2. Fast QRS Detection with an Optimized Knowledge-Based Method: Evaluation on 11 Standard ECG Databases

    PubMed Central

    Elgendi, Mohamed

    2013-01-01

    The current state-of-the-art in automatic QRS detection methods show high robustness and almost negligible error rates. In return, the methods are usually based on machine-learning approaches that require sufficient computational resources. However, simple-fast methods can also achieve high detection rates. There is a need to develop numerically efficient algorithms to accommodate the new trend towards battery-driven ECG devices and to analyze long-term recorded signals in a time-efficient manner. A typical QRS detection method has been reduced to a basic approach consisting of two moving averages that are calibrated by a knowledge base using only two parameters. In contrast to high-accuracy methods, the proposed method can be easily implemented in a digital filter design. PMID:24066054

  3. Methods and considerations for the analysis and standardization of assessing muscle sympathetic nerve activity in humans.

    PubMed

    White, Daniel W; Shoemaker, J Kevin; Raven, Peter B

    2015-12-01

    The technique of microneurography and the assessment of muscle sympathetic nerve activity (MSNA) are used in laboratories throughout the world. The variables used to describe MSNA, and the criteria by which these variables are quantified from the integrated neurogram, vary among studies and laboratories and, therefore, can become confusing to those starting to learn the technique. Therefore, the purpose of this educational review is to discuss guidelines and standards for the assessment of sympathetic nervous activity through the collection and analysis of MSNA. This review will reiterate common practices in the collection of MSNA, but will also introduce considerations for the evaluation and physiological inference using MSNA.

  4. Lattice Boltzmann method for simulation of compressible flows on standard lattices.

    PubMed

    Prasianakis, Nikolaos I; Karlin, Iliya V

    2008-07-01

    The recently introduced lattice Boltzmann model for thermal flow simulation on a standard lattice [Prasianakis and Karlin, Phys. Rev. E 76, 016702 (2007)] is studied numerically in the case where compressibility effects are essential. It is demonstrated that the speed of sound and shock propagation are described correctly in a wide temperature range, and that it is possible to take into account additional physics such as heat sources and sinks. A remarkable simplicity of the model makes it viable for engineering applications in subsonic flows with large temperature and density variations. PMID:18764078

  5. Methods and considerations for the analysis and standardization of assessing muscle sympathetic nerve activity in humans.

    PubMed

    White, Daniel W; Shoemaker, J Kevin; Raven, Peter B

    2015-12-01

    The technique of microneurography and the assessment of muscle sympathetic nerve activity (MSNA) are used in laboratories throughout the world. The variables used to describe MSNA, and the criteria by which these variables are quantified from the integrated neurogram, vary among studies and laboratories and, therefore, can become confusing to those starting to learn the technique. Therefore, the purpose of this educational review is to discuss guidelines and standards for the assessment of sympathetic nervous activity through the collection and analysis of MSNA. This review will reiterate common practices in the collection of MSNA, but will also introduce considerations for the evaluation and physiological inference using MSNA. PMID:26299824

  6. California teachers' perceptions of standards-based reform in middle school science: A mixed-methods study

    NASA Astrophysics Data System (ADS)

    Leggett, Allison Gail Wilson

    The No Child Left Behind (NCLB) Act of 2001 presented one of the most significant and comprehensive literacy reforms in many years (McDonnell, 2005; U.S. Department of Education, 2006). The era of school accountability and standards based reform has brought many challenges and changes to public schools. Increasingly, public officials and educational administrators are asked to use standards based assessments to make high-stakes decisions, such as whether a student will move on to the next grade level or receive a diploma (American Psychological Association, 2005). It is important to understand any shifts in teachers' perceptions and to identify the changes teachers are making as they implement standards-based reform. This mixed-methods study was designed to assess teachers' perceptions of changes related to standards-based reform as supported by Fullan's (2001) change theory and transformational leadership theory. Survey questions sought to identify teacher perceptions of changes in curriculum, instruction and daily practice as schools documented and incorporated standards-based reform and began focusing on preparing students for the California Standards Test in Science (CSTS). Using descriptive statistical analysis and in-depth interviews, results show favorable insight towards standards-based reform. The survey was distributed to 30 middle school science teachers from 10 low-performing schools in Los Angeles, California. Results were analyzed using Spearman rank-ordered correlations. Interviews were conducted on middle school teachers represented by each grade level. Teachers who receive more support from administrators have more positive attitudes toward all aspects of SBR and the CSTS as measured in this study. No school should overlook the potential of a supportive administration in its effort to improve school programs.

  7. Gel microbead cultivation with a subenrichment procedure can yield better bacterial cultivability from a seawater sample than standard plating method

    NASA Astrophysics Data System (ADS)

    Ji, Shiqi; Zhao, Rui; Yin, Qi; Zhao, Yuan; Liu, Chenguang; Xiao, Tian; Zhang, Xiaohua

    2012-03-01

    A gel microbead (GMD) cultivation method was employed to cultivate microorganisms from an amphioxus breeding zone in Qingdao, P. R. China. The culture results were compared with those by standard plating method. In the GMD-based method, the microcolony-forming GMDs were sorted by fluorescence-activated cell sorting (FACS). To further get pure cultures, a subsequent enrichment culture and a streaking purification procedure were conducted on marine R2A medium. Eighty bacterial strains isolated by the GMD-based method were randomly selected for sequencing. These isolates belonged to Alphaproteobacteria (33%), Gammaproteobacteria (44%), Bacteroidetes (11%), Actinobacteria (5%), Firmicutes (5%), Epsilonproteobacteria (1%), and Verrucomicrobia (1%), the last two groups being usually difficult to culture. The 16S rRNA gene sequences revealed a diverse community with 91.1%-100% of the bacterial rRNAs similarities. Thirteen strains were sharing 16S rRNA gene sequence which was less than 97% similar to any other rRNA genes currently deposited in TYP16S database. Seventy isolates derived from the standard plating method fell into 4 different taxonomic groups: Alphaproteobacteria (9%), Gammaproteobacteria (81%), Bacteroidetes (7%) and Firmicutes (3%) with a 16S rRNA gene sequence similarities between 95.8%-100%, in which only 3 strains were sharing 16S rRNA gene sequence of less than 97%. The results indicated that the GMD-based method with subenrichment culture yielded more taxonomic groups and more novel microbial strains, including members of previously rarely cultured groups, when compared with the standard plating method, and that this method markedly improved the bacterial cultivability.

  8. Who accepts responsibility for their transgressions?

    PubMed

    Schumann, Karina; Dweck, Carol S

    2014-12-01

    After committing an offense, transgressors can optimize their chances of reconciling with the victim by accepting responsibility. However, transgressors may be motivated to avoid admitting fault because it can feel threatening to accept blame for harmful behavior. Who, then, is likely to accept responsibility for a transgression? We examined how implicit theories of personality--whether people see personality as malleable (incremental theory) or fixed (entity theory)--influence transgressors' likelihood of accepting responsibility. We argue that incremental theorists may feel less threatened by accepting responsibility because they are more likely to view the situation as an opportunity for them to grow as a person and develop their relationship with the victim. We found support for our predictions across four studies using a combination of real-world and hypothetical offenses, and correlational and experimental methods. These studies therefore identify an important individual difference factor that can lead to more effective responses from transgressors. PMID:25252938

  9. Validation of Five Minimally Obstructive Methods to Estimate Physical Activity Energy Expenditure in Young Adults in Semi-Standardized Settings

    PubMed Central

    Schneller, Mikkel B.; Pedersen, Mogens T.; Gupta, Nidhi; Aadahl, Mette; Holtermann, Andreas

    2015-01-01

    We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4), against indirect calorimetry, to estimate total energy expenditure (EE) of different activities in semi-standardized settings. Fourteen participants performed a standardized and semi-standardized protocol including seven daily life activity types, while having their EE measured by indirect calorimetry. Simultaneously, physical activity was quantified by an ActivPAL3, two ActiGraph GT3X+’s and an Actiheart. EE was estimated by the standard ActivPAL3 software (ActivPAL), ActiGraph GT3X+ (ActiGraph) and Actiheart (Actiheart), and by a combination of activity type recognition via Acti4 software and activity counts per minute (CPM) of either a hip- or thigh-worn ActiGraph GT3X+ (AGhip + Acti4 and AGthigh + Acti4). At group level, estimated physical activities EE by Actiheart (MSE = 2.05) and AGthigh + Acti4 (MSE = 0.25) were not significantly different from measured EE by indirect calorimetry, while significantly underestimated by ActiGraph, ActivPAL and AGhip + Acti4. AGthigh + Acti4 and Actiheart explained 77% and 45%, of the individual variations in measured physical activity EE by indirect calorimetry, respectively. This study concludes that combining accelerometer data from a thigh-worn ActiGraph GT3X+ with activity type recognition improved the accuracy of activity specific EE estimation against indirect calorimetry in semi-standardized settings compared to previously validated methods using CPM only. PMID:25781506

  10. [Non-standard method of reconstruction of the abdominal aorta for a giant aneurysm].

    PubMed

    Gaibov, A D; Baratov, A K; Sadriev, O N; Gaibova, Z V; Sharipov, Z R

    2016-01-01

    Abdominal aortic aneurysms are encountered predominantly in elderly patients suffering from severe concomitant diseases. Therefore, the rate of various complications associated with resection of aortic aneurysm amounts to 30%, with lethality in separate cohorts of patients reaching 43.7%. According the authors' opinion, in the development of intra- and postoperative complications of special importance is the duration of aortic clamping accompanied by severe haemodynamic alterations in coronary, cerebral and renal vessels. These changes are key moments in the development of fatal outcomes. In order to reduce the duration of aortic clamp the authors suggested a non-standard surgical technique of prosthetic repair of the abdominal aorta. Presented herein is a clinical case report illustrating this technique. The patient operated on according to this technique was discharged in a satisfactory condition with no serious postoperative complications. The proposed non-standard surgical technique makes it possible to reduce the duration of aortic cross-clamping in resection of an aneurysm by 10-12 minutes. PMID:27336353

  11. Integrating 6th Grade Geometry Standards into a Waldorf Methods Charter School

    ERIC Educational Resources Information Center

    Watterson, Ilie Alma

    2006-01-01

    Many Waldorf methods charter schools are opening up in California today. They are publicly funded schools bringing Waldorf methods into public education. In today's political climate all public schools must pass the state's bar of academic success measured by their Adequate Yearly Progress (AYP). Because these scores are based largely on…

  12. Transverse flowmetry of carbon particles based on photoacoustic Doppler standard deviation using an auto-correlation method

    NASA Astrophysics Data System (ADS)

    Lu, Tao; Sun, Li-jun

    2015-05-01

    In order to measure the flow velocity of carbon particle suspension perpendicular to the receiving axis of ultrasound transducer, the standard deviation of photoacoustic Doppler frequency spectrum is used to estimate the bandwidth broadening, and the spectrum standard deviation is calculated by an auto-correlation method. A 532 nm pulsed laser with the repetition rate of 20 Hz is used as a pumping source to generate photoacoustic signal. The photoacoustic signals are detected using a focused PZT ultrasound transducer with the central frequency of 10 MHz. The suspension of carbon particles is driven by a syringe pump. The complex photoacoustic signal is calculated by Hilbert transformation from time domain signal before auto-correlation. The standard deviation of the Doppler bandwidth broadening is calculated by averaging the auto-correlation results of several individual A scans. The feasibility of the proposed method is demonstrated by measuring the spectrum standard deviation of the transversal carbon particle flow from 5.0 mm/s to 8.4 mm/s. The experimental results show that the auto-correlation result is approximately linearly distributed within the measuring range.

  13. Age and Acceptance of Euthanasia.

    ERIC Educational Resources Information Center

    Ward, Russell A.

    1980-01-01

    Study explores relationship between age (and sex and race) and acceptance of euthanasia. Women and non-Whites were less accepting because of religiosity. Among older people less acceptance was attributable to their lesser education and greater religiosity. Results suggest that quality of life in old age affects acceptability of euthanasia. (Author)

  14. 48 CFR 9904.413-64 - Transition method.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Transition method. 9904... ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.413-64 Transition method. (a) To be acceptable, any method of transition from compliance with Standard 9904.413 in effect prior to March 30, 1995,...

  15. Mindfulness, Acceptance and Catastrophizing in Chronic Pain

    PubMed Central

    de Boer, Maaike J.; Steinhagen, Hannemike E.; Versteegen, Gerbrig J.; Struys, Michel M. R. F.; Sanderman, Robbert

    2014-01-01

    Objectives Catastrophizing is often the primary target of the cognitive-behavioral treatment of chronic pain. Recent literature on acceptance and commitment therapy (ACT) suggests an important role in the pain experience for the concepts mindfulness and acceptance. The aim of this study is to examine the influence of mindfulness and general psychological acceptance on pain-related catastrophizing in patients with chronic pain. Methods A cross-sectional survey was conducted, including 87 chronic pain patients from an academic outpatient pain center. Results The results show that general psychological acceptance (measured with the AAQ-II) is a strong predictor of pain-related catastrophizing, independent of gender, age and pain intensity. Mindfulness (measured with the MAAS) did not predict levels of pain-related catastrophizing. Discussion Acceptance of psychological experiences outside of pain itself is related to catastrophizing. Thus, acceptance seems to play a role in the pain experience and should be part of the treatment of chronic pain. The focus of the ACT treatment of chronic pain does not necessarily have to be on acceptance of pain per se, but may be aimed at acceptance of unwanted experiences in general. Mindfulness in the sense of “acting with awareness” is however not related to catastrophizing. Based on our research findings in comparisons with those of other authors, we recommend a broader conceptualization of mindfulness and the use of a multifaceted questionnaire for mindfulness instead of the unidimensional MAAS. PMID:24489915

  16. Are standard wastewater treatment plant design methods suitable for any municipal wastewater?

    PubMed

    Insel, G; Güder, B; Güneş, G; Ubay Cokgor, E

    2012-01-01

    The design and operational parameters of an activated sludge system were analyzed treating the municipal wastewaters in Istanbul. The design methods of ATV131, Metcalf & Eddy together with model simulations were compared with actual plant operational data. The activated sludge model parameters were determined using 3-month dynamic data for the biological nutrient removal plant. The ATV131 method yielded closer sludge production, total oxygen requirement and effluent nitrogen levels to the real plant after adopting correct influent chemical oxygen demand (COD) fractionation. The enhanced biological phosphorus removal (EBPR) could not easily be predicted with ATV131 method due to low volatile fatty acids (VFA) potential.

  17. Attributes Affecting the Acceptance and Integration of Best Practices in Secondary Professional-Technical Education (PTE): A Mixed-Methods Study

    ERIC Educational Resources Information Center

    Nevill, Harold Anderson

    2010-01-01

    This mixed-methods study examined which attributes Professional-Technical Education (PTE) teachers desire to see in the best practices presented to them. The study used data from two separate pilot studies to create a survey administered during the June, 2009 PTE summer conference; which was returned by 229 responders; and in addition used to…

  18. Controlled Vestibular Stimulation, Standardization Of A Physiological Method To Release Stress In College Students.

    PubMed

    Sailesh, Kumar Sai; Mukkadan, J K

    2015-01-01

    The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation. It has been observed that the anxiety status was significantly decreased after vestibular stimulation. There is a need for future study with larger sample size to substantiate the therapeutic validity of vestibular stimulation as a physiological treatment for stress relief and stress related disorders among college students.

  19. Controlled Vestibular Stimulation, Standardization Of A Physiological Method To Release Stress In College Students.

    PubMed

    Sailesh, Kumar Sai; Mukkadan, J K

    2015-01-01

    The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation. It has been observed that the anxiety status was significantly decreased after vestibular stimulation. There is a need for future study with larger sample size to substantiate the therapeutic validity of vestibular stimulation as a physiological treatment for stress relief and stress related disorders among college students. PMID:27530012

  20. Design predictions and diagnostic test methods for hydronic heating systems in ASHRAE standard 152P

    SciTech Connect

    Andrews, J.W.

    1996-04-01

    A new method of test for residential thermal distribution efficiency is currently being developed under the auspices of the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE). The initial version of this test method is expected to have two main approaches, or ``pathways,`` designated Design and Diagnostic. The Design Pathway will use builder`s information to predict thermal distribution efficiency in new construction. The Diagnostic Pathway will use simple tests to evaluate thermal distribution efficiency in a completed house. Both forced-air and hydronic systems are included in the test method. This report describes an approach to predicting and measuring thermal distribution efficiency for residential hydronic heating systems for use in the Design and Diagnostic Pathways of the test method. As written, it is designed for single-loop systems with any type of passive radiation/convection (baseboard or radiators). Multiloop capability may be added later.