Science.gov

Sample records for access cdc research

  1. Evolution of a CDC Public Health Research Agenda for Low-Risk Prostate Cancer.

    PubMed

    Hall, Ingrid J; Lee Smith, Judith

    2015-12-01

    Men with prostate cancer face difficult choices when selecting a therapy for localized prostate cancer. Comparative data from controlled studies are lacking and clinical opinions diverge about the benefits and harms of treatment options. Consequently, there is limited guidance for patients regarding the impact of treatment decisions on quality of life. There are opportunities for public health to intervene at several decision-making points. Information on typical quality of life outcomes associated with specific prostate cancer treatments could help patients select treatment options. From 2003 to present, the Division of Cancer Prevention and Control at CDC has supported projects to explore patient information-seeking behavior post-diagnosis, caregiver and provider involvement in treatment decision making, and patient quality of life following prostate cancer treatment. CDC's work also includes research that explores barriers and facilitators to the presentation of active surveillance as a viable treatment option and promotes equal access to information for men and their caregivers. This article provides an overview of the literature and considerations that initiated establishing a prospective public health research agenda around treatment decision making. Insights gathered from CDC-supported studies are poised to enhance understanding of the process of shared decision making and the influence of patient, caregiver, and provider preferences on the selection of treatment choices. These findings provide guidance about attributes that maximize patient experiences in survivorship, including optimal quality of life and patient and caregiver satisfaction with information, treatment decisions, and subsequent care.

  2. Public Health Research at the CDC: Implications for Communication Sciences and Disorders

    ERIC Educational Resources Information Center

    Boyle, C.; Alexander, M.

    2005-01-01

    The following paper provides an overview of public health research at the Centers for Disease Control and Prevention (CDC), with emphasis on research involving speech, language and hearing disorders. Public health research involves a sequence of activities from disease tracking to disease prevention. Public health focuses on populations and works…

  3. "Accessions": Researching, Designing Higher Education

    ERIC Educational Resources Information Center

    Taylor, Yvette

    2011-01-01

    This brief viewpoint piece depicts educational (dis)engagements apparent in researching and (re)designing higher education in and through "Accessions". "Accessions", a collaborative research-design project, probed at how cultures, climates and conditions of higher education may be reproducing or reshaping social inequalities and divisions. Here,…

  4. 78 FR 46953 - CDC and ATSDR Use of the SF-424 Research and Related Forms (Application Packages) in Grants.gov...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... HUMAN SERVICES Centers for Disease Control and Prevention CDC and ATSDR Use of the SF-424 Research and... and Prevention (CDC), Department of Health and Human Services. ACTION: Notice. Purpose NIH's... form sets available through Grants.gov . CDC and other agencies serviced by eRA use the `Competition...

  5. Minorities Access to Research Careers.

    ERIC Educational Resources Information Center

    American Association of State Colleges and Universities, Washington, DC.

    The Minorities Access to Research Careers (MARC) program at Hunter College, New York is designed to provide an in-depth 2-year research training experience for minority students in order to prepare them for graduate school and eventual research careers in alcohol, drug abuse, and mental health fields. The target groups include Blacks, Hispanics,…

  6. Enhancing Ocean Research Data Access

    NASA Astrophysics Data System (ADS)

    Chandler, Cynthia; Groman, Robert; Shepherd, Adam; Allison, Molly; Arko, Robert; Chen, Yu; Fox, Peter; Glover, David; Hitzler, Pascal; Leadbetter, Adam; Narock, Thomas; West, Patrick; Wiebe, Peter

    2014-05-01

    The Biological and Chemical Oceanography Data Management Office (BCO-DMO) works in partnership with ocean science investigators to publish data from research projects funded by the Biological and Chemical Oceanography Sections and the Office of Polar Programs Antarctic Organisms & Ecosystems Program at the U.S. National Science Foundation. Since 2006, researchers have been contributing data to the BCO-DMO data system, and it has developed into a rich repository of data from ocean, coastal and Great Lakes research programs. While the ultimate goal of the BCO-DMO is to ensure preservation of NSF funded project data and to provide open access to those data, achievement of those goals is attained through a series of related phases that benefits from active collaboration and cooperation with a large community of research scientists as well as curators of data and information at complementary data repositories. The BCO-DMO is just one of many intermediate data management centers created to facilitate long-term preservation of data and improve access to ocean research data. Through partnerships with other data management professionals and active involvement in local and global initiatives, BCO-DMO staff members are working to enhance access to ocean research data available from the online BCO-DMO data system. Continuing efforts in use of controlled vocabulary terms, development of ontology design patterns and publication of content as Linked Open Data are contributing to improved discovery and availability of BCO-DMO curated data and increased interoperability of related content available from distributed repositories. We will demonstrate how Semantic Web technologies (e.g. RDF/XML, SKOS, OWL and SPARQL) have been integrated into BCO-DMO data access and delivery systems to better serve the ocean research community and to contribute to an expanding global knowledge network.

  7. Broadening access to medical care during a severe influenza pandemic: the CDC nurse triage line project.

    PubMed

    Koonin, Lisa M; Hanfling, Dan

    2013-03-01

    The impact of a severe influenza pandemic could be overwhelming to hospital emergency departments, clinics, and medical offices if large numbers of ill people were to simultaneously seek care. While current planning guidance to reduce surge on hospitals and other medical facilities during a pandemic largely focuses on improving the "supply" of medical care services, attention on reducing "demand" for such services is needed by better matching patient needs with alternative types and sites of care. Based on lessons learned during the 2009 H1N1 pandemic, the Centers for Disease Control and Prevention and its partners are currently exploring the acceptability and feasibility of using a coordinated network of nurse triage telephone lines during a pandemic to assess the health status of callers, help callers determine the most appropriate site for care (eg, hospital ED, outpatient center, home), disseminate information, provide clinical advice, and provide access to antiviral medications for ill people, if appropriate. As part of this effort, the integration and coordination of poison control centers, existing nurse advice lines, 2-1-1 information lines, and other hotlines are being investigated.

  8. Using Evidence-Based Parenting Programs to Advance CDC Efforts in Child Maltreatment Prevention. Research Brief

    ERIC Educational Resources Information Center

    Valle, Linda Anne; Whitaker, Daniel J.; Lutzker, John R.; Filene, Jill H.; Wyatt, Jennifer M.; Cephas, Kendell C.; Hoover, D. Michele

    2004-01-01

    The Centers for Disease Control and Prevention (CDC) recognize child maltreatment as a serious public health problem with extensive short- and long-term health effects. In addition to the immediate physical and emotional effects of maltreatment, children who have experienced abuse and neglect are at increased risk of adverse health effects and…

  9. Correlates of Access to Business Research Databases

    ERIC Educational Resources Information Center

    Gottfried, John C.

    2010-01-01

    This study examines potential correlates of business research database access through academic libraries serving top business programs in the United States. Results indicate that greater access to research databases is related to enrollment in graduate business programs, but not to overall enrollment or status as a public or private institution.…

  10. Open Access, Education Research, and Discovery

    ERIC Educational Resources Information Center

    Furlough, Michael

    2010-01-01

    Background/Context: The open access movement has successfully drawn attention to economic and political aspects of scholarly communication through a significant body of commentary that debates the merits of open access and the potential damage it may do to scholarly publishing. Researchers within the field of education research, notably John…

  11. Access and Performance Measures in Research Libraries.

    ERIC Educational Resources Information Center

    Shapiro, Beth J.

    1991-01-01

    Argues that, as library roles change, providing access to information resources is becoming more important than acquisition of library resources and that libraries should be evaluated based upon what they actually do. Access and performance measures are proposed to supplement the statistics collected by the Association of Research Libraries. (30…

  12. Supporting Public Access to Research Results

    ERIC Educational Resources Information Center

    Lapinski, P. Scott; Osterbur, David; Parker, Joshua; McCray, Alexa T.

    2014-01-01

    We posed the question of what services an academic library can best provide to support the NIH Public Access Policy. We approached the answer to this question through education, collaboration, and tool-building. As a result, over the last four years we have engaged over 1,500 participants in discussions of public access to research results, forged…

  13. Research facility access & science education

    SciTech Connect

    Rosen, S.P.; Teplitz, V.L.

    1994-10-01

    As Congress voted to terminate the Superconducting Super Collider (SSC) Laboratory in October of 1993, the Department of Energy was encouraged to maximize the benefits to the nation of approximately $2 billion which had already been expended to date on its evolution. Having been recruited to Texas from other intellectually challenging enclaves around the world, many regional scientists, especially physicists, of course, also began to look for viable ways to preserve some of the potentially short-lived gains made by Texas higher education in anticipation of {open_quotes}the SSC era.{close_quotes} In fact, by November, 1993, approximately 150 physicists and engineers from thirteen Texas universities and the SSC itself, had gathered on the SMU campus to discuss possible re-uses of the SSC assets. Participants at that meeting drew up a petition addressed to the state and federal governments requesting the creation of a joint Texas Facility for Science Education and Research. The idea was to create a facility, open to universities and industry alike, which would preserve the research and development infrastructure and continue the educational mission of the SSC.

  14. CDC and ATSDR electronic information resources for health officers.

    PubMed

    Friede, A; O'Carroll, P W

    1996-12-01

    This article catalogs some of the Centers for Disease Control and Prevention's (CDC) more important information resource offerings, which make public health information accessible via computer and automated telephone systems and on electronic media (diskette and CD-ROM). We review mechanisms for (1) finding and retrieving CDC reports, (2) querying CDC's numeric data files, (3) transmitting surveillance and other data files to CDC, (4) exchanging electronic mail with CDC staff, and (5) disseminating state and local public health information and data by using CDC tools. Each resource is followed with a section on how to obtain access to these resources.

  15. Catalyst-Free Three-Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer-Type Rearrangement.

    PubMed

    Wang, Peng-Min; Pu, Fan; Liu, Ke-Yan; Li, Chao-Jun; Liu, Zhong-Wen; Shi, Xian-Ying; Fan, Juan; Yang, Ming-Yu; Wei, Jun-Fa

    2016-04-25

    A catalyst-free multicomponent CDC reaction is rarely reported, especially for the intermolecular tandem CDC cyclization, which represents an important strategy for constructing cyclic compounds. Herein, a three-component tandem CDC cyclization by a Pummerer-type rearrangement to afford biologically relevant isoindolinones from aromatic acids, amides, and DMSO, is described. This intermolecular tandem reaction undergoes a C(sp(2) )-H/C(sp(3) )-H cross-dehydrogenative coupling, C-N bond formation, and intramolecular amidation. A notable feature of this novel protocol is avoiding a catalyst and additive (apart from oxidant).

  16. Catalyst-Free Three-Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer-Type Rearrangement.

    PubMed

    Wang, Peng-Min; Pu, Fan; Liu, Ke-Yan; Li, Chao-Jun; Liu, Zhong-Wen; Shi, Xian-Ying; Fan, Juan; Yang, Ming-Yu; Wei, Jun-Fa

    2016-04-25

    A catalyst-free multicomponent CDC reaction is rarely reported, especially for the intermolecular tandem CDC cyclization, which represents an important strategy for constructing cyclic compounds. Herein, a three-component tandem CDC cyclization by a Pummerer-type rearrangement to afford biologically relevant isoindolinones from aromatic acids, amides, and DMSO, is described. This intermolecular tandem reaction undergoes a C(sp(2) )-H/C(sp(3) )-H cross-dehydrogenative coupling, C-N bond formation, and intramolecular amidation. A notable feature of this novel protocol is avoiding a catalyst and additive (apart from oxidant). PMID:26998754

  17. NIH support of Centers for AIDS Research and Department of Health Collaborative Public Health Research: advancing CDC's Enhanced Comprehensive HIV Prevention Planning project.

    PubMed

    Greenberg, Alan E; Purcell, David W; Gordon, Christopher M; Flores, Stephen; Grossman, Cynthia; Fisher, Holly H; Barasky, Rebecca J

    2013-11-01

    The contributions reported in this supplemental issue highlight the relevance of NIH-funded CEWG research to health department–supported HIV prevention and care activities in the 9 US cities with the highest numbers of AIDS cases. The project findings have the potential to enhance ongoing HIV treatment and care services and to advance the wider scientific agenda. The HIV testing to care continuum, while providing a framework to help track progress on national goals, also can reflect the heterogeneities of local epidemics. The collaborative research that is highlighted in this issue not only reflects a locally driven research agenda but also demonstrates research methods, data collection tools, and collaborative processes that could be encouraged across jurisdictions. Projects such as these, capitalizing on the integrated efforts of NIH, CDC, DOH, and academic institutions, have the potential to contribute to improvements in the HIV care continuum in these communities, bringing us closer to realizing the HIV prevention and treatment goals of the NHAS.

  18. The use of theory based semistructured elicitation questionnaires: formative research for CDC's Prevention Marketing Initiative.

    PubMed Central

    Middlestadt, S E; Bhattacharyya, K; Rosenbaum, J; Fishbein, M; Shepherd, M

    1996-01-01

    Through one of its many HIV prevention programs, the Prevention Marketing Initiative, the Centers for Disease Control and Prevention promotes a multifaceted strategy for preventing the sexual transmission of HIV/AIDS among people less than 25 years of age. The Prevention Marketing Initiative is an application of marketing and consumer-oriented technologies that rely heavily on behavioral research and behavior change theories to bring the behavioral and social sciences to bear on practical program planning decisions. One objective of the Prevention Marketing Initiative is to encourage consistent and correct condom use among sexually active young adults. Qualitative formative research is being conducted in several segments of the population of heterosexually active, unmarried young adults between 18 and 25 using a semistructured elicitation procedure to identify and understand underlying behavioral determinants of consistent condom use. The purpose of this paper is to illustrate the use of this type of qualitative research methodology in designing effective theory-based behavior change interventions. Issues of research design and data collection and analysis are discussed. To illustrate the methodology, results of content analyses of selected responses to open-ended questions on consistent condom use are presented by gender (male, female), ethnic group (white, African American), and consistency of condom use (always, sometimes). This type of formative research can be applied immediately to designing programs and is invaluable for valid and relevant larger-scale quantitative research. PMID:8862153

  19. Providing Data Access for Interdisciplinary Research

    NASA Astrophysics Data System (ADS)

    Hooper, R. P.; Couch, A.

    2012-12-01

    Developing an interdisciplinary understanding of human and environmental interactions with water requires access to a variety of data kinds collected by various organizations. The CUAHSI Hydrologic Information System (HIS) is a standards-based, services-oriented architecture designed for time-series data. Such data represents an important type of data in water studies. Through the efforts of HIS, a standard transmission language, WaterML2, has been adopted by the Open Geospatial Consortium and is under consideration by the World Meteorologic Organization as an international standards. Web services have also been developed to retrieve data and metadata. HIS is completed with a metadata catalog, hosted by San Diego Supercomputing Center, which indexes more than 20 million time series provided from over 90 different services. This catalog is supported through a hierarchically organized controlled vocabulary that is open for community input and mediation. Data publishers include federal agencies, universities, state agencies, and non-profit organizations such as watershed associations. Accessing data from such a broad spectrum of sources through a uniform service standard promises to truly transform the way in which hydrologic research is done. CUAHSI HIS is a large-scale prototype at this time, but a proposal is under consideration by the National Science Foundation to operationalize HIS through a data facility, tentatively called the CUAHSI Water Data Center. Establishing HIS is an important step to enable research into human-environment interactions with water, but it is only one step. Other data structures will need to be made accessible and interoperable to support this research. Some data—such as two-dimensional GIS coverages—already have widely used standards for transmission and sharing. The US Federal government has long operated a clearinghouse for federal geographic data that is now being augmented with other services such as ArcGIS OnLine. Other data

  20. Cat Scratch Can Sometimes Lead to Serious Illness: CDC

    MedlinePlus

    ... news/fullstory_161086.html Cat Scratch Can Sometimes Lead to Serious Illness: CDC But there's no need ... enter the skin and infect the person," said lead researcher Dr. Christina Nelson, a CDC medical officer. ...

  1. Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus

    PubMed Central

    Nishioka, K; Doki, Y; Shiozaki, H; Yamamoto, H; Tamura, S; Yasuda, T; Fujiwara, Y; Yano, M; Miyata, H; Kishi, K; Nakagawa, H; Shamma, A; Monden, M

    2001-01-01

    CDC25A, CDC25B and CDC25C belong to a family of protein phosphatases which activate the cyclin-dependent kinase at different points of the cell cycle. According to accumulating evidence, CDC25A and CDC25B seem to possess oncogenic properties. We have analysed these expressions by immunohistochemistry, western blot and RT-PCR in a series of 100 patients with squamous cell carcinoma of the oesophagus. When compared with non-cancerous cells, CDC25A and CDC25B were strongly expressed in the cytoplasm of cancer cells, with positive (+) classification in 46% (46 cases) and 48% (48 cases), respectively. There was no significant correlation between CDC25A and CDC25B expression, nor was there any association with the expression of other cell cycle-regulating molecules, including cyclin D1, Rb, p16INK4, p27KIP1 and PCNA (proliferating cell nuclear antigen). CDC25A (+), as well as CDC25B (+), was more frequently found in patients with deeper tumour invasion and lymph node metastasis, while tumour size was correlated only with CDC25A expression. Postoperative survival was significantly poorer for CDC25A (+) patients than CDC25A (–) patients, but was not affected by the CDC25B status. Nuclear localization of CDC25A was observed in 51 cases (51%), regardless of its cytoplasmic expression, and was not associated with clinico-pathological factors or prognosis. Multivariate analysis revealed only the CDC25A status to be an independent significant prognostic factor among these biological and clinico-pathological factors. CDC25A but not CDC25B may be a new prognostic factor for squamous cell carcinoma of the oesophagus. Thus, regulation of the G1 checkpoint in the cell cycle may be important in oesophageal carcinogenesis, which may also involve many other oncogenes. © 2001 Cancer Research Campaign http://www.bjcancer.com PMID:11487274

  2. Access anxiety: HIPAA and historical research.

    PubMed

    Lawrence, Susan C

    2007-10-01

    The Health Insurance Portability and Accountability Act of 1996 (HIPAA) establishes new standards for the protection of private health information in the United States. The Privacy Rule, one of the specific regulatory provisions of the act, went into effect 14 April 2003 for covered health care providers, institutions, and businesses. The Privacy Rule directly affected medical archivists and their collections. It has significant implications for historians of health care, as well. The Privacy Rule is the first major regulation that protects the privacy of the deceased in perpetuity. It establishes requirements that researchers must satisfy in order to gain access to "individually identifiable health information" held by HIPAA-protected institutions. While these requirements will burden historians in some cases, the Privacy Rule could open up opportunities for well-prepared historians to work with a more extensive range of twentieth-century documents.

  3. 17 CFR 200.510 - Access by historical researchers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Access by historical... Security Information and Material § 200.510 Access by historical researchers. (a) Persons outside the executive branch performing historical research may have access to information over which the Commission...

  4. 17 CFR 200.510 - Access by historical researchers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Access by historical... Security Information and Material § 200.510 Access by historical researchers. (a) Persons outside the executive branch performing historical research may have access to information over which the Commission...

  5. 17 CFR 200.510 - Access by historical researchers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Access by historical... Security Information and Material § 200.510 Access by historical researchers. (a) Persons outside the executive branch performing historical research may have access to information over which the Commission...

  6. 17 CFR 200.510 - Access by historical researchers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Access by historical... Security Information and Material § 200.510 Access by historical researchers. (a) Persons outside the executive branch performing historical research may have access to information over which the Commission...

  7. 17 CFR 200.510 - Access by historical researchers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Access by historical... Security Information and Material § 200.510 Access by historical researchers. (a) Persons outside the executive branch performing historical research may have access to information over which the Commission...

  8. Introduction: CDC Health Disparities and Inequalities Report - United States, 2013.

    PubMed

    Meyer, Pamela A; Yoon, Paula W; Kaufmann, Rachel B

    2013-11-22

    This supplement is the second CDC Health Disparities and Inequalities Report (CHDIR). The 2011 CHDIR was the first CDC report to assess disparities across a wide range of diseases, behavioral risk factors, environmental exposures, social determinants, and health-care access (CDC. CDC Health Disparities and Inequalities Report-United States, 2011. MMWR 2011;60[Suppl; January 14, 2011]). The 2013 CHDIR provides new data for 19 of the topics published in 2011 and 10 new topics. When data were available and suitable analyses were possible for the topic area, disparities were examined for population characteristics that included race and ethnicity, sex, sexual orientation, age, disability, socioeconomic status, and geographic location. The purpose of this supplement is to raise awareness of differences among groups regarding selected health outcomes and health determinants and to prompt actions to reduce disparities. The findings in this supplement can be used by practitioners in public health, academia and clinical medicine; the media; the general public; policymakers; program managers; and researchers to address disparities and help all persons in the United States live longer, healthier, and more productive lives.

  9. Engineering and public health at CDC.

    PubMed

    Earnest, G Scott; Reed, Laurence D; Conover, D; Estill, C; Gjessing, C; Gressel, M; Hall, R; Hudock, S; Hudson, H; Kardous, C; Sheehy, J; Topmiller, J; Trout, D; Woebkenberg, M; Amendola, A; Hsiao, H; Keane, P; Weissman, D; Finfinger, G; Tadolini, S; Thimons, E; Cullen, E; Jenkins, M; McKibbin, R; Conway, G; Husberg, B; Lincoln, J; Rodenbeck, S; Lantagne, D; Cardarelli, J

    2006-12-22

    Engineering is the application of scientific and technical knowledge to solve human problems. Using imagination, judgment, and reasoning to apply science, technology, mathematics, and practical experience, engineers develop the design, production, and operation of useful objects or processes. During the 1940s, engineers dominated the ranks of CDC scientists. In fact, the first CDC director, Assistant Surgeon General Mark Hollis, was an engineer. CDC engineers were involved in malaria control through the elimination of standing water. Eventually the CDC mission expanded to include prevention and control of dengue, typhus, and other communicable diseases. The development of chlorination, water filtration, and sewage treatment were crucial to preventing waterborne illness. Beginning in the 1950s, CDC engineers began their work to improve public health while developing the fields of environmental health, industrial hygiene, and control of air pollution. Engineering disciplines represented at CDC today include biomedical, civil, chemical, electrical, industrial, mechanical, mining, and safety engineering. Most CDC engineers are located in the National Institute for Occupational Safety and Health (NIOSH) and the Agency for Toxic Substances and Disease Registry (ATSDR). Engineering research at CDC has a broad stakeholder base. With the cooperation of industry, labor, trade associations, and other stakeholders and partners, current work includes studies of air contaminants, mining, safety, physical agents, ergonomics, and environmental hazards. Engineering solutions remain a cornerstone of the traditional "hierarchy of controls" approach to reducing public health hazards.

  10. Apartment Dwellers More Likely to Smoke: CDC

    MedlinePlus

    ... co-author Brian King, deputy director of research translation in the CDC's Office on Smoking and Health. "Opening windows or using ventilation systems does not effectively eliminate secondhand smoke exposure in multi-unit housing." The study was published ...

  11. CDC Vital Signs: Hispanic Health

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  12. CDC Vital Signs: Legionnaires' Disease

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  13. CDC Vital Signs: Preventing Melanoma

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  14. Subject Access to "Pornography" for Serious Research Purposes.

    ERIC Educational Resources Information Center

    Moya, Cynde

    2001-01-01

    Examines some of the research needs in academic disciplines for access to pornographic materials, and looks at tools, such as thesauri and Web directories, which have been built to help searchers find materials. Discusses research needs for access to materials; tools built by librarians to subject analyze material; and Internet words for indexing…

  15. Open Access Publishing in Indian Premier Research Institutions

    ERIC Educational Resources Information Center

    Bhat, Mohammad Hanief

    2009-01-01

    Introduction: Publishing research findings in open access journals is a means of enhancing visibility and consequently increasing the impact of publications. This study provides an overview of open access publishing in premier research institutes of India. Method: The publication output of each institution from 2003 to 2007 was ascertained through…

  16. Research Investigation of Information Access Methods

    ERIC Educational Resources Information Center

    Heinrichs, John H.; Sharkey, Thomas W.; Lim, Jeen-Su

    2006-01-01

    This study investigates the satisfaction of library users at Wayne State University who utilize alternative information access methods. The LibQUAL+[TM] desired and perceived that satisfaction ratings are used to determine the user's "superiority gap." By focusing limited library resources to address "superiority gap" issues identified by each…

  17. Educator Access and Application of Music Research

    ERIC Educational Resources Information Center

    Paney, Andrew S.

    2011-01-01

    One role of music education research is to "enhance knowledge regarding the teaching and learning of music," however, despite the fact that music education research is published several times each year in multiple journals, a communication gap between music researchers and music teachers continues to exist. Three suggested reasons…

  18. Polio Nearly Vanquished: CDC

    MedlinePlus

    ... CDC, Rotary International, the World Health Organization (WHO), United Nations Children's Fund (UNICEF) and the Bill and Melinda ... president, Rotary International; Reza Hossaini, director, polio eradication, United Nations Children's Fund HealthDay Copyright (c) 2016 HealthDay . All ...

  19. ACNP and NILDE: Essential Tools for Access to Scientific Research

    NASA Astrophysics Data System (ADS)

    Brunetti, F.; Bonora, O.; Filippucci, G.

    2015-04-01

    This paper describes ACNP and NILDE, the two main Italian cooperative systems for access to scientific information. Used by the Italian Astronomical Libraries (IAL), they are two essential channels to access information resources that are otherwise unreachable. At the same time, they allow IAL (Italian Astronomical Libraries) to share their very rich and unique holdings with other research and university libraries.

  20. Access to Research Information Using Integrated Technologies.

    ERIC Educational Resources Information Center

    Krause, Susan M.

    1994-01-01

    Because of the schedules, preferences, and varied information needs of researchers at Baylor College of Medicine (Texas), a system of computer and telecommunications technologies was developed to facilitate research and project planning. The system integrates cellular phones, voice mail, facsimile publishing, distributed document delivery, and…

  1. Leading the Way for Open Access Research

    ERIC Educational Resources Information Center

    Warschauer, Mark

    2016-01-01

    "Language Learning & Technology" ("LLT") was launched in the mid-1990s out of a collaboration between the University of Hawai'i National Foreign Language Resource Center (NFLRC) and the Michigan State University Center for Language Education Research (CLEAR). Like other online journals started in the 1990s, "LLT"…

  2. Samples and data accessibility in research biobanks: an explorative survey

    PubMed Central

    Matteucci, Giulia; Dominici, Valentina; Destro Bisol, Giovanni; Rufo, Fabrizio

    2016-01-01

    Biobanks, which contain human biological samples and/or data, provide a crucial contribution to the progress of biomedical research. However, the effective and efficient use of biobank resources depends on their accessibility. In fact, making bio-resources promptly accessible to everybody may increase the benefits for society. Furthermore, optimizing their use and ensuring their quality will promote scientific creativity and, in general, contribute to the progress of bio-medical research. Although this has become a rather common belief, several laboratories are still secretive and continue to withhold samples and data. In this study, we conducted a questionnaire-based survey in order to investigate sample and data accessibility in research biobanks operating all over the world. The survey involved a total of 46 biobanks. Most of them gave permission to access their samples (95.7%) and data (85.4%), but free and unconditioned accessibility seemed not to be common practice. The analysis of the guidelines regarding the accessibility to resources of the biobanks that responded to the survey highlights three issues: (i) the request for applicants to explain what they would like to do with the resources requested; (ii) the role of funding, public or private, in the establishment of fruitful collaborations between biobanks and research labs; (iii) the request of co-authorship in order to give access to their data. These results suggest that economic and academic aspects are involved in determining the extent of sample and data sharing stored in biobanks. As a second step of this study, we investigated the reasons behind the high diversity of requirements to access biobank resources. The analysis of informative answers suggested that the different modalities of resource accessibility seem to be largely influenced by both social context and legislation of the countries where the biobanks operate. PMID:26966643

  3. Samples and data accessibility in research biobanks: an explorative survey.

    PubMed

    Capocasa, Marco; Anagnostou, Paolo; D'Abramo, Flavio; Matteucci, Giulia; Dominici, Valentina; Destro Bisol, Giovanni; Rufo, Fabrizio

    2016-01-01

    Biobanks, which contain human biological samples and/or data, provide a crucial contribution to the progress of biomedical research. However, the effective and efficient use of biobank resources depends on their accessibility. In fact, making bio-resources promptly accessible to everybody may increase the benefits for society. Furthermore, optimizing their use and ensuring their quality will promote scientific creativity and, in general, contribute to the progress of bio-medical research. Although this has become a rather common belief, several laboratories are still secretive and continue to withhold samples and data. In this study, we conducted a questionnaire-based survey in order to investigate sample and data accessibility in research biobanks operating all over the world. The survey involved a total of 46 biobanks. Most of them gave permission to access their samples (95.7%) and data (85.4%), but free and unconditioned accessibility seemed not to be common practice. The analysis of the guidelines regarding the accessibility to resources of the biobanks that responded to the survey highlights three issues: (i) the request for applicants to explain what they would like to do with the resources requested; (ii) the role of funding, public or private, in the establishment of fruitful collaborations between biobanks and research labs; (iii) the request of co-authorship in order to give access to their data. These results suggest that economic and academic aspects are involved in determining the extent of sample and data sharing stored in biobanks. As a second step of this study, we investigated the reasons behind the high diversity of requirements to access biobank resources. The analysis of informative answers suggested that the different modalities of resource accessibility seem to be largely influenced by both social context and legislation of the countries where the biobanks operate.

  4. Samples and data accessibility in research biobanks: an explorative survey.

    PubMed

    Capocasa, Marco; Anagnostou, Paolo; D'Abramo, Flavio; Matteucci, Giulia; Dominici, Valentina; Destro Bisol, Giovanni; Rufo, Fabrizio

    2016-01-01

    Biobanks, which contain human biological samples and/or data, provide a crucial contribution to the progress of biomedical research. However, the effective and efficient use of biobank resources depends on their accessibility. In fact, making bio-resources promptly accessible to everybody may increase the benefits for society. Furthermore, optimizing their use and ensuring their quality will promote scientific creativity and, in general, contribute to the progress of bio-medical research. Although this has become a rather common belief, several laboratories are still secretive and continue to withhold samples and data. In this study, we conducted a questionnaire-based survey in order to investigate sample and data accessibility in research biobanks operating all over the world. The survey involved a total of 46 biobanks. Most of them gave permission to access their samples (95.7%) and data (85.4%), but free and unconditioned accessibility seemed not to be common practice. The analysis of the guidelines regarding the accessibility to resources of the biobanks that responded to the survey highlights three issues: (i) the request for applicants to explain what they would like to do with the resources requested; (ii) the role of funding, public or private, in the establishment of fruitful collaborations between biobanks and research labs; (iii) the request of co-authorship in order to give access to their data. These results suggest that economic and academic aspects are involved in determining the extent of sample and data sharing stored in biobanks. As a second step of this study, we investigated the reasons behind the high diversity of requirements to access biobank resources. The analysis of informative answers suggested that the different modalities of resource accessibility seem to be largely influenced by both social context and legislation of the countries where the biobanks operate. PMID:26966643

  5. Towards a joint approach for access to environmental research infrastructures

    NASA Astrophysics Data System (ADS)

    Mann, Ingrid; Tjulin, Anders; Pappalardo, Gelsomina; Gagliardi, Simone; Philippin, Sabine; Sellegri, Karine; Chabbi, Abad

    2016-04-01

    Geoscience is a multi-disciplinary field and in many cases its research benefits from considering different kinds of observational results. Geoscience observations are in some cases of direct interest also to the public. For these reasons effective knowledge transfer and access also across disciplines are especially important for research infrastructures (RIs) in the environmental domain. More generally, the ultimate success of a RI is measured by its scientific outcome and this is best achieved based on efficient access for a broad scientific community. In this presentation the authors report activities to develop governance tools so that the access to environmental RIs and to the data that they provide is common, fair and based on scientific rationale, regarding at the same time economically and technically reasonable use of limited resources. Implementing such governance tools will indeed foster and widen the access to RIs across environmental science domains while addressing societal challenges. The strategies also need to be flexible and sustainable over the expected lifetimes of the RIs. The reported activities involve researchers from different projects and environmental subdomains that come together in the project ENVRI_plus. ENVRI_plus is a Cluster project of RIs that brings together the current ESFRI roadmap RIs in the environmental domain and other relevant existing and developing RIs and projects. ENVRI_plus also offers opportunities for free-of-charge transnational access to four multi-disciplinary research platforms. These calls for access target research groups and companies wishing to conduct research or to test instruments for cross-disciplinary topics within the environmental domains atmosphere, biosphere, marine, and solid earth. They are initiated specifically to gain experience with access across different disciplines (further information is given at www.envriplus.eu). ENVRI_plus receives funding from the European Union's Horizon 2020 research

  6. Research in image management and access

    NASA Technical Reports Server (NTRS)

    Vondran, Raymond F.; Barron, Billy J.

    1993-01-01

    Presently, the problem of over-all library system design has been compounded by the accretion of both function and structure to a basic framework of requirements. While more device power has led to increased functionality, opportunities for reducing system complexity at the user interface level have not always been pursued with equal zeal. The purpose of this book is therefore to set forth and examine these opportunities, within the general framework of human factors research in man-machine interfaces. Human factors may be viewed as a series of trade-off decisions among four polarized objectives: machine resources and user specifications; functionality and user requirements. In the past, a limiting factor was the availability of systems. However, in the last two years, over one hundred libraries supported by many different software configurations have been added to the Internet. This document includes a statistical analysis of human responses to five Internet library systems by key features, development of the ideal online catalog system, and ideal online catalog systems for libraries and information centers.

  7. High Drama Marks Hearing over Free Access to Published Research

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2008-01-01

    A life-and-death battle is going on over public access to federally financed research--life for taxpayers and many scientists, and death for publishers. Or so each side claims. That battle, whose outcome will affect many university researchers, kicked into high gear on Capitol Hill on September 11, as the combatants debated the merits of a bill…

  8. National Center on Accessibility: Putting Research into Practice.

    ERIC Educational Resources Information Center

    Bowerman, Jennifer; Robb, Gary

    2001-01-01

    A collaborative program of Indiana University and the National Park Service, the National Center on Accessibility provides research, training, and technical assistance to link the needs and preferences of people with disabilities to practitioners designing facilities and planning programs in parks and recreation. Research and recommendations…

  9. Accessing and recruiting children for research in schools.

    PubMed

    Rice, Marti; Bunker, Kylan D; Kang, Duck-Hee; Howell, Carol C; Weaver, Michael

    2007-06-01

    Gaining access to the schools and recruiting children as research participants are challenging tasks. To facilitate gaining access to the schools, multiple strategies are necessary, including understanding specific characteristics of the schools, using the proper lines of authority and communication, identifying the gatekeepers, and persuading the schools of the significance and mutual benefits from the study. Once access is gained, strategies for successful recruitment of children include use of developmentally appropriate motivators and incentives; multilevel communications with administrators, principals, teachers, staff, parents/guardians, and children; and provision of privacy and confidentiality during data collection and sharing of the findings. Specific examples from an ongoing study are used to illustrate helpful strategies.

  10. Participatory research and evaluation: from best practices for all states to achievable practices within each state in the context of the Master Settlement Agreement.

    PubMed

    Mercer, Shawna L; MacDonald, Goldie; Green, Lawrence W

    2004-07-01

    Because the Centers for Disease Control and Prevention (CDC) already assisted state tobacco control initiatives, many state health departments turned to CDC for guidance on how to use Master Settlement Agreement monies. This article describes how CDC funded participatory research to establish local evidence and provided technical assistance for participatory program evaluation. The article (a) presents a telephone interview study of principal investigators (PIs) to determine how CDC could best facilitate participatory research and (b) identifies factors CDC considered to devise evaluation technical assistance that reflected local context. The interview study identified 8 areas where PIs needed CDC's support to undertake participatory research: continuity, timeliness, flexibility, clear and explicit expectations, appropriate and instructive accountability, creation of a vision for participatory research, tailored technical assistance, and enhancement of partner collaboration and support. These findings are being used to inform CDC's research funding. Meanwhile, user-driven technical assistance for participatory evaluation is being accessed by many states.

  11. Poverty, Equity and Access to Education in Bangladesh. CREATE Pathways to Access. Research Monograph No. 51

    ERIC Educational Resources Information Center

    Hossain, Altaf; Zeitlyn, Benjamin

    2010-01-01

    Bangladesh has made great improvements in the scale and quality of access to education in recent years and gender equality has almost been achieved in primary education (World Bank, 2008). Evidence from CREATE's nationwide community and school survey (ComSS) confirms results from other research (such as Al-Samarrai, 2009) which suggests that…

  12. Common pathways toward informing policy and environmental strategies to promote health: a study of CDC's Prevention Research Centers.

    PubMed

    Neri, Elizabeth M; Stringer, Kate J; Spadaro, Antonia J; Ballman, Marie R; Grunbaum, Jo Anne

    2015-03-01

    This study examined the roles academic researchers can play to inform policy and environmental strategies that promote health and prevent disease. Prevention Research Centers (PRCs) engage in academic-community partnerships to conduct applied public health research. Interviews were used to collect data on the roles played by 32 PRCs to inform policy and environmental strategies that were implemented between September 2009 and September 2010. Descriptive statistics were calculated in SAS 9.2. A difference in roles played was observed depending on whether strategies were policy or environmental. Of the policy initiatives, the most common roles were education, research, and partnership. In contrast, the most prevalent roles the PRCs played in environmental approaches were research and providing health promotion resources. Academic research centers play various roles to help inform policy and environmental strategies.

  13. NOAA Plans for Improving Public Access to Science Research (Invited)

    NASA Astrophysics Data System (ADS)

    de la Beaujardiere, J.

    2013-12-01

    The White House Office of Science and Technology Policy (OSTP) issued a memorandum on 2013 February 22 calling for federal agencies to enhance public access to research results (PARR), and required agencies to submit, within 6 months of the memo, draft plans explaining how they would implement the requirements. For the National Oceanic and Atmospheric Administration (NOAA), research results include digital data about the Earth's environment and publications based on those data. Regarding environmental data, NOAA is already very active in ensuring and improving public access. Indeed, National Weather Service (NWS) data was highlighted as one of the good examples in the OSTP memo. More generally, the NOAA National Data Centers, the Environmental Data Management Committee (EDMC), and scientific and technical personnel across the agency are striving to ensure NOAA data are discoverable and accessible on-line, well-documented and formatted for usability, and preserved for future generations as a national asset. This presentation will describe current and potential activities in support of public access to NOAA and NOAA-funded environmental data. Regarding publications, there is greater uncertainty. The fundamental issue is how to ensure no-cost access (after an embargo period) to publications that typically require subscriptions. That issue must be addressed at the interagency level with the journal publishers. The plan indicates that NOAA will adopt shared mechanisms and agreements to the extent possible rather than building new systems. Some elements remain under discussion; this presentation will be limited to those aspects on which there is general agreement.

  14. Interoperable Access to NCAR Research Data Archive Collections

    NASA Astrophysics Data System (ADS)

    Schuster, D.; Ji, Z.; Worley, S. J.; Manross, K.

    2014-12-01

    The National Center for Atmospheric Research (NCAR) Research Data Archive (RDA) provides free access to 600+ observational and gridded dataset collections. The RDA is designed to support atmospheric and related sciences research, updated frequently where datasets have ongoing production, and serves data to 10,000 unique users annually. The traditional data access options include web-based direct archive file downloads, user selected data subsets and format conversions produced by server-side computations, and client and cURL-based APIs for routine scripted data retrieval. To enhance user experience and utility, the RDA now also offers THREDDS Data Server (TDS) access for many highly valued dataset collections. TDS offered datasets are presented as aggregations, enabling users to access an entire dataset collection, that can be comprised of 1000's of files, through a single virtual file. The OPeNDAP protocol, supported by the TDS, allows compatible tools to open and access these virtual files remotely, and make the native data file format transparent to the end user. The combined functionality (TDS/OPeNDAP) gives users the ability to browse, select, visualize, and download data from a complete dataset collection without having to transfer archive files to a local host. This presentation will review the TDS basics and describe the specific TDS implementation on the RDA's diverse archive of GRIB-1, GRIB-2, and gridded NetCDF formatted dataset collections. Potential future TDS implementation on in-situ observational dataset collections will be discussed. Illustrative sample cases will be used to highlight the end users benefits from this interoperable data access to the RDA.

  15. CDC Kerala--The Untold Story.

    PubMed

    Nair, M K C; Leela, Leena Mundapalliyil; George, Babu; Bhaskaran, Deepa; Pillai, Asokan Nataraja; Sarasamma, Harikumaran Nair Gopinathan Nair

    2016-05-01

    This article is our life time experience in conceptualizing and systematically developing Child Development Centre (CDC) Kerala in the last 25 years, from a research project to a national training centre in child and adolescent development and premarital counseling. CDC Kerala's major contribution was in creating a 'conceptual framework' of a valid link between childhood disability, low birth weight, adolescent girls' nutrition and fetal onset adult lifestyle diseases. It all started with a randomized controlled trial (RCT) proving beyond doubt that early stimulation is effective in improving the neurodevelopmental status of high risk babies at one and two years and the same cohort was followed-up in detail at 5, 13, 16, 19 and 24 completed years. The process of establishing CDC Kerala is being presented under (i) clinical child development, (ii) adolescent care counseling, (iii) young adults and premarital counseling and (iv) institution building.

  16. CDC Kerala--The Untold Story.

    PubMed

    Nair, M K C; Leela, Leena Mundapalliyil; George, Babu; Bhaskaran, Deepa; Pillai, Asokan Nataraja; Sarasamma, Harikumaran Nair Gopinathan Nair

    2016-05-01

    This article is our life time experience in conceptualizing and systematically developing Child Development Centre (CDC) Kerala in the last 25 years, from a research project to a national training centre in child and adolescent development and premarital counseling. CDC Kerala's major contribution was in creating a 'conceptual framework' of a valid link between childhood disability, low birth weight, adolescent girls' nutrition and fetal onset adult lifestyle diseases. It all started with a randomized controlled trial (RCT) proving beyond doubt that early stimulation is effective in improving the neurodevelopmental status of high risk babies at one and two years and the same cohort was followed-up in detail at 5, 13, 16, 19 and 24 completed years. The process of establishing CDC Kerala is being presented under (i) clinical child development, (ii) adolescent care counseling, (iii) young adults and premarital counseling and (iv) institution building. PMID:26988580

  17. AAS Nova and Astrobites: Making current astronomy research accessible

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna; Astrobites Team

    2016-10-01

    AAS Nova and Astrobites are two resources available for astronomers, astronomy students, and astronomy enthusiasts to keep up with some of the most recent research published across the field of astronomy. Both supported by the AAS, these two daily astrophysical literature blogs provide accessible summaries of recent publications on the arXiv and in AAS journals. We present the goals, content, and readership of AAS Nova and Astrobites, and discuss how they might be used as tools in the undergraduate classroom.

  18. 49 CFR 8.29 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Access by historical researchers and former... INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Access to Information § 8.29 Access by historical researchers and former Presidential appointees. (a) Historical researchers. (1) Persons outside the...

  19. 49 CFR 8.29 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Access by historical researchers and former... INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Access to Information § 8.29 Access by historical researchers and former Presidential appointees. (a) Historical researchers. (1) Persons outside the...

  20. 49 CFR 8.29 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Access by historical researchers and former... INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Access to Information § 8.29 Access by historical researchers and former Presidential appointees. (a) Historical researchers. (1) Persons outside the...

  1. 49 CFR 8.29 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Access by historical researchers and former... INFORMATION: CLASSIFICATION/DECLASSIFICATION/ACCESS Access to Information § 8.29 Access by historical researchers and former Presidential appointees. (a) Historical researchers. (1) Persons outside the...

  2. Research on a dynamic workflow access control model

    NASA Astrophysics Data System (ADS)

    Liu, Yiliang; Deng, Jinxia

    2007-12-01

    In recent years, the access control technology has been researched widely in workflow system, two typical technologies of that are RBAC (Role-Based Access Control) and TBAC (Task-Based Access Control) model, which has been successfully used in the role authorizing and assigning in a certain extent. However, during the process of complicating a system's structure, these two types of technology can not be used in minimizing privileges and separating duties, and they are inapplicable when users have a request of frequently changing on the workflow's process. In order to avoid having these weakness during the applying, a variable flow dynamic role_task_view (briefly as DRTVBAC) of fine-grained access control model is constructed on the basis existed model. During the process of this model applying, an algorithm is constructed to solve users' requirements of application and security needs on fine-grained principle of privileges minimum and principle of dynamic separation of duties. The DRTVBAC model is implemented in the actual system, the figure shows that the task associated with the dynamic management of role and the role assignment is more flexible on authority and recovery, it can be met the principle of least privilege on the role implement of a specific task permission activated; separated the authority from the process of the duties completing in the workflow; prevented sensitive information discovering from concise and dynamic view interface; satisfied with the requirement of the variable task-flow frequently.

  3. BCO-DMO: Enabling Access to Federally Funded Research Data

    NASA Astrophysics Data System (ADS)

    Kinkade, D.; Allison, M. D.; Chandler, C. L.; Groman, R. C.; Rauch, S.; Shepherd, A.; Gegg, S. R.; Wiebe, P. H.; Glover, D. M.

    2013-12-01

    In a February, 2013 memo1, the White House Office of Science and Technology Policy (OSTP) outlined principles and objectives to increase access by the public to federally funded research publications and data. Such access is intended to drive innovation by allowing private and commercial efforts to take full advantage of existing resources, thereby maximizing Federal research dollars and efforts. The Biological and Chemical Oceanography Data Management Office (BCO-DMO; bco-dmo.org) serves as a model resource for organizations seeking compliance with the OSTP policy. BCO-DMO works closely with scientific investigators to publish their data from research projects funded by the National Science Foundation (NSF), within the Biological and Chemical Oceanography Sections (OCE) and the Division of Polar Programs Antarctic Organisms & Ecosystems Program (PLR). BCO-DMO addresses many of the OSTP objectives for public access to digital scientific data: (1) Marine biogeochemical and ecological data and metadata are disseminated via a public website, and curated on intermediate time frames; (2) Preservation needs are met by collaborating with appropriate national data facilities for data archive; (3) Cost and administrative burden associated with data management is minimized by the use of one dedicated office providing hundreds of NSF investigators support for data management plan development, data organization, metadata generation and deposition of data and metadata into the BCO-DMO repository; (4) Recognition of intellectual property is reinforced through the office's citation policy and the use of digital object identifiers (DOIs); (5) Education and training in data stewardship and use of the BCO-DMO system is provided by office staff through a variety of venues. Oceanographic research data and metadata from thousands of datasets generated by hundreds of investigators are now available through BCO-DMO. 1 White House Office of Science and Technology Policy, Memorandum for

  4. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs...

  5. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs...

  6. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs...

  7. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC membership. 120.822 Section... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.822 CDC membership. (a) CDC Membership. A CDC must have at least 25 members (or stockholders for for-profit CDCs...

  8. Open Access to Research Articles and Data: Library Roles

    NASA Astrophysics Data System (ADS)

    Joseph, Heather

    2015-08-01

    Over the past decade, a handful of key developments have caused scholars and researchers to rethink not only the way they conduct their work, but also the way in which they communicate it to others. The advent of the Internet has provided unprecedented opportunities for immediate, cost effective global connectivity, opening up new possibilities for collaboration and communication. This has resulted in scholarship increasingly being conducted in the online environment, and a vast amount of new digital information being generated and made widely available to those interested in using it. Additionally, the Internet is a dynamic environment, with new channels for producing and sharing information in a myriad of formats emerging frequently.In higher education, the momentum of the burgeoning movement towards "open" sharing of information of all kinds continues to gain traction. In particular, advancements in the areas of opening up access to articles and reserch data are increasingly visible. In both of these areas, academic and research libraries are playing important, central roles in promoting the awareness of the potential costs and benefits of a more open research environment, as well as defining new roles for libraries in this digital environment.As this push for grater openness continues, these fronts are intersecting in interesting and potentially transformative ways. The Open Access and Open Data movements share fundamental philosophical commonalities that make collaboration a natural outcome. Both movements place a premium on reducing barriers to discovering and accessing pertinent digital information. Perhaps even more significantly, both explicitly recognize that enabling productive use of digital information is key to unlocking its full value. As a result of these shared priorities, there are a wide variety of common strategies that libraries can take to help advance research, presenting new opportunities for deeper collaboration to take place.This talk will

  9. CDC Vital Signs: Cervical Cancer is Preventable

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  10. CDC Vital Signs: Preventing Repeat Teen Births

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  11. CDC Vital Signs: Where's the Sodium?

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  12. CDC Vital Signs: Teen Drinking and Driving

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  13. CDC Vital Signs: Prescription Painkiller Overdoses

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  14. CDC Vital Signs: Today's Heroin Epidemic

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  15. CDC Vital Signs: Preventing Teen Pregnancy

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  16. 77 FR 44224 - Access to Confidential Business Information by Eastern Research Group, Incorporated

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... AGENCY Access to Confidential Business Information by Eastern Research Group, Incorporated AGENCY... will authorize its contractor Eastern Research Group, Incorporated (ERG) to access Confidential Business Information (CBI) which has been submitted to EPA under the authority of all sections of...

  17. 76 FR 23586 - Access to Confidential Business Information by Syracuse Research Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... AGENCY Access to Confidential Business Information by Syracuse Research Corporation AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA has authorized its contractor, Syracuse Research... or determined to be Confidential Business Information (CBI). DATES: Access to the confidential...

  18. 77 FR 68769 - Access to Confidential Business Information by Eastern Research Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... AGENCY Access to Confidential Business Information by Eastern Research Group AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA has authorized its contractor, Eastern Research Group... Confidential Business Information (CBI). DATES: Access to the confidential data occurred on or about...

  19. BIOPACK: the ground controlled late access biological research facility.

    PubMed

    van Loon, Jack J W A

    2004-03-01

    Future Space Shuttle flights shall be characterized by activities necessary to further build the International Space Station, ISS. During these missions limited resources are available to conduct biological experiments in space. The Shuttles' Middeck is a very suitable place to conduct science during the ISS assembly missions or dedicated science missions. The BIOPACK, which flew its first mission during the STS-107, provides a versatile Middeck Locker based research tool for gravitational biology studies. The core facility occupies the space of only two Middeck Lockers. Experiment temperatures are controlled for bacteria, plant, invertebrate and mammalian cultures. Gravity levels and profiles can be set ranging from 0 to 2.0 x g on three independent centrifuges. This provides the experimenter with a 1.0 x g on-board reference and intermediate hypogravity and hypergravity data points to investigate e.g. threshold levels in biological responses. Temperature sensitive items can be stored in the facilities' -10 degrees C and +4 degrees C stowage areas. During STS-107 the facility also included a small glovebox (GBX) and passive temperature controlled units (PTCU). The GBX provides the experimenter with two extra levels of containment for safe sample handling. This biological research facility is a late access (L-10 hrs) laboratory, which, when reaching orbit, could automatically be starting up reducing important experiment lag-time and valuable crew time. The system is completely telecommanded when needed. During flight system parameters like temperatures, centrifuge speeds, experiment commanding or sensor readouts can be monitored and changed when needed. Although ISS provides a wide range of research facilities there is still need for an STS-based late access facility such as the BIOPACK providing experimenters with a very versatile research cabinet for biological experiments under microgravity and in-flight control conditions.

  20. Supporting open access to clinical trial data for researchers: The Duke Clinical Research Institute-Bristol-Myers Squibb Supporting Open Access to Researchers Initiative.

    PubMed

    Pencina, Michael J; Louzao, Darcy M; McCourt, Brian J; Adams, Monique R; Tayyabkhan, Rehbar H; Ronco, Peter; Peterson, Eric D

    2016-02-01

    There are growing calls for sponsors to increase transparency by providing access to clinical trial data. In response, Bristol-Myers Squibb and the Duke Clinical Research Institute have collaborated on a new initiative, Supporting Open Access to Researchers. The aim is to facilitate open sharing of Bristol-Myers Squibb trial data with interested researchers. Key features of the Supporting Open Access to Researchers data sharing model include an independent review committee that ensures expert consideration of each proposal, stringent data deidentification/anonymization and protection of patient privacy, requirement of prespecified statistical analysis plans, and independent review of manuscripts before submission for publication. We believe that these approaches will promote open science by allowing investigators to verify trial results as well as to pursue interesting secondary uses of trial data without compromising scientific integrity. PMID:26856217

  1. Insights into Cdc13 Dependent Telomere Length Regulation

    SciTech Connect

    M Mason; E Skordalakes

    2011-12-31

    Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. It caps the ends of chromosomes thus preventing chromosome end-to-end fusions and exonucleolytic degradation, events that could lead to genomic instability and senescence, the hallmark of aging. Cdc13 is also involved in telomere length regulation by recruiting or preventing access of telomerase to the telomeric overhang. Recruitment of telomerase to the telomeres for G-strand extension is required for continuous cell division, while preventing its access to the telomeres through capping the chromosome ends prevents mitotic events that could lead to cell immortality, the hall mark of carcinogenesis. Cdc13 and its putative homologues human CTC1 and POT1 are therefore key to many biological processes directly associated with life extension and cancer prevention and can be viewed as an ideal target for cancer and age related therapies.

  2. CDC/1000: a Control Data Corporation remote batch terminal emulator for Hewlett-Packard minicomputers

    SciTech Connect

    Berg, D.E.

    1981-02-01

    The Control Data Corporation Type 200 User Terminal utilizes a unique communications protocol to provide users with batch mode remote terminal access to Control Data computers. CDC/1000 is a software subsystem that implements this protocol on Hewlett-Packard minicomputers running the Real Time Executive III, IV, or IVB operating systems. This report provides brief descriptions of the various software modules comprising CDC/1000, and contains detailed instructions for integrating CDC/1000 into the Hewlett Packard operating system and for operating UTERM, the user interface program for CDC/1000. 6 figures.

  3. Promoting Access to Higher Education and Identifying Access Students: How Useful Is Research on Participation by Socio-Economic Group?

    ERIC Educational Resources Information Center

    Bernard, Julie

    2006-01-01

    Research conducted by Patrick Clancy and by Fitzpatrick Associates and Philip O'Connell on the level of representation of socio-economic groups amongst higher education entrants has been a key element in the development of access policy and practice in Ireland. This article reviews the context for the development of access and explores the…

  4. Addressing Earth Science Data Access Challenges through User Experience Research

    NASA Astrophysics Data System (ADS)

    Hemmings, S. N.; Banks, B.; Kendall, J.; Lee, C. M.; Irwin, D.; Toll, D. L.; Searby, N. D.

    2013-12-01

    The NASA Capacity Building Program (Earth Science Division, Applied Sciences Program) works to enhance end-user capabilities to employ Earth observation and Earth science (EO/ES) data in decision-making. Open data access and user-tailored data delivery strategies are critical elements towards this end. User Experience (UX) and User Interface (UI) research methods can offer important contributions towards addressing data access challenges, particularly at the interface of science application/product development and product transition to end-users. This presentation focuses on developing nation contexts and describes methods, results, and lessons learned from two recent UX/UI efforts conducted in collaboration with NASA: the SERVIRglobal.net redesign project and the U.S. Water Partnership (USWP) Portal development effort. SERVIR, a collaborative venture among NASA, USAID, and global partners, seeks to improve environmental management and climate change response by helping governments and other stakeholders integrate EO and geospatial technologies into decision-making. The USWP, a collaboration among U.S. public and private sectors, harnesses U.S.-based resources and expertise to address water challenges in developing nations. SERVIR's study, conducted from 2010-2012, assessed and tested user needs, preferences, and online experiences to generate a more user-friendly online data portal at SERVIRglobal.net. The portal provides a central access interface to data and products from SERVIR's network of hubs in East Africa, the Hindu Kush Himalayas, and Mesoamerica. The second study, conducted by the USWP Secretariat and funded by the U.S. Department of State, seeks to match U.S.-based water information resources with developing nation stakeholder needs. The USWP study utilizes a multi-pronged approach to identify key design requirements and to understand the existing water data portal landscape. Adopting UX methods allows data distributors to design customized UIs that

  5. Misusing informed consent: a critique of limitations on research subjects' access to genetic research results.

    PubMed

    Banks, T M

    2000-01-01

    Express denials of access to genetic research results are being drafted into consent instruments. Some commentators suggest that the principle of beneficence can justify such a denial of access. This paper provides an ethical and legal critique of the use of consent instruments to disclaim responsibility for on-going disclosure by genetic researchers. Currently, the law of torts provides only weak protection for on-going disclosure for research subjects. The most substantive rights are to be found in the law of fiduciary obligations. The author concludes that, notwithstanding arguments to the contrary, there should be a presumption of disclosure in genetic research, unless the research subject elects otherwise. The author outlines one possible exception to this general presumption.

  6. South Asian Nomads--A Literature Review. CREATE Pathways to Access. Research Monograph No. 58

    ERIC Educational Resources Information Center

    Sharma, Anita

    2011-01-01

    This review of literature on South Asian nomads is part of a series of monographs on educational access published by the Consortium for Research on Educational Access Transitions and Equity (CREATE). In the context of India, most recent work has focused on access to the education system for the poor. CREATE research in India has focused on …

  7. Improving open access to the results of USGS research (Invited)

    NASA Astrophysics Data System (ADS)

    Bristol, S.

    2013-12-01

    Since its establishment under the Organic Act of March 3, 1879, the U.S. Geological Survey (USGS) has been committed to classifying and characterizing 'the geological structure, mineral resources, and products of the national domain.' Over time, the pursuit of this mission and understanding the products of the national domain has involved a broad scientific pursuit to understand complex Earth system processes and includes topographic, geologic, biogeographic, and other types of mapping; chemical, physical, hydrological, and biological research; and the application of computer and data science. As science and technology have evolved, classification and characterization of the Nation's natural resources has come to be embodied in digital data of various structure and form. Fundamentally, scientific publications and data produced through research and monitoring form the core of the USGS mission. They are an organizational and national treasure held and provided in trust for the American people and for the global scientific community. The recent memo from the Office of Science and Technology Policy (OSTP) on 'Increasing Access to the Results of Federally Funded Scientific Research' is part of an overall initiative toward open digital government that dovetails well with the USGS mission. The objectives outlined in the memo correspond directly to goals and objectives of the 2007 USGS Science Strategy ('Facing Tomorrow's Challenges--U.S. Geological Survey Science in the Decade 2007-2017') and the recently released Science Strategy Plans across all USGS Mission Areas. The USGS response to the OSTP memo involves reinforcing aspects of the USGS commitment to open and free access to scholarly publications and data along with improvements to some of the underlying technological systems that facilitate search and discovery. These actions also align with the USGS response to the Executive Order on May 9, 2013, entitled 'Making Open and Machine Readable the New Default for

  8. What do we mean by Internet access? A framework for health researchers.

    PubMed

    Bush, Nigel E; Bowen, Deborah J; Wooldridge, Jean; Ludwig, Abi; Meischke, Hendrika; Robbins, Robert

    2004-10-01

    Much is written about Internet access, Web access, Web site accessibility, and access to online health information. The term access has, however, a variety of meanings to authors in different contexts when applied to the Internet, the Web, and interactive health communication. We have summarized those varied uses and definitions and consolidated them into a framework that defines Internet and Web access issues for health researchers. We group issues into two categories: connectivity and human interface. Our focus is to conceptualize access as a multicomponent issue that can either reduce or enhance the public health utility of electronic communications.

  9. CDC WONDER: a cooperative processing architecture for public health.

    PubMed

    Friede, A; Rosen, D H; Reid, J A

    1994-01-01

    CDC WONDER is an information management architecture designed for public health. It provides access to information and communications without the user's needing to know the location of data or communication pathways and mechanisms. CDC WONDER users have access to extractions from some 40 databases; electronic mail (e-mail); and surveillance data processing. System components include the Remote Client, the Communications Server, the Queue Managers, and Data Servers and Process Servers. The Remote Client software resides in the user's machine; other components are at the Centers for Disease Control and Prevention (CDC). The Remote Client, the Communications Server, and the Applications Server provide access to the information and functions in the Data Servers and Process Servers. The system architecture is based on cooperative processing, and components are coupled via pure message passing, using several protocols. This architecture allows flexibility in the choice of hardware and software. One system limitation is that final results from some subsystems are obtained slowly. Although designed for public health, CDC WONDER could be useful for other disciplines that need flexible, integrated information exchange.

  10. Cdc13 N-Terminal Dimerization DNA Binding and Telomere Length Regulation

    SciTech Connect

    M Mitchell; J Smith; M Mason; S Harper; D Speicher; F Johnson; E Skordalakes

    2011-12-31

    The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that is directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres.

  11. Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation ▿ †

    PubMed Central

    Mitchell, Meghan T.; Smith, Jasmine S.; Mason, Mark; Harper, Sandy; Speicher, David W.; Johnson, F. Brad; Skordalakes, Emmanuel

    2010-01-01

    The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that is directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres. PMID:20837709

  12. Access and preservation of digital research content: Linked open data services - A research library perspective

    NASA Astrophysics Data System (ADS)

    Kraft, Angelina; Sens, Irina; Löwe, Peter; Dreyer, Britta

    2016-04-01

    Globally resolvable, persistent digital identifiers have become an essential tool to enable unambiguous links between published research results and their underlying digital resources. In addition, this unambiguous identification allows citation. In an ideal research world, any scientific content should be citable and the coherent content, as well as the citation itself, should be persistent. However, today's scientists do not just produce traditional research papers - they produce comprehensive digital collections of objects which, alongside digital texts, include digital resources such as research data, audiovisual media, digital lab journals, images, statistics and software code. Researchers start to look for services which allow management of these digital resources with minimum time investment. In light of this, we show how the German National Library of Science and Technology (TIB) develops supportive frameworks to accompany the life cycle of scientific knowledge generation and transfer. This includes technical infrastructures for • indexing, cataloguing, digital preservation, DOI names and licencing for text and digital objects (the TIB DOI registration, active since 2004) and • a digital repository for the deposition and provision of accessible, traceable and citeable research data (RADAR). One particular problem for the management of data originating from (collaborating) research infrastructures is their dynamic nature in terms of growth, access rights and quality. On a global scale, systems for access and preservation are in place for the big data domains (e.g. environmental sciences, space, climate). However, the stewardship for disciplines without a tradition of data sharing, including the fields of the so-called long tail, remains uncertain. The RADAR - Research Data Repository - project establishes a generic end-point data repository, which can be used in a collaborative way. RADAR enables clients to upload, edit, structure and describe their

  13. Where are the food deserts? An evaluation of policy-relevant measures of community food access in South Carolina

    PubMed Central

    Liese, Angela D.; Hibbert, James D.; Ma, Xiaoguang; Bell, Bethany A.; Battersby, Sarah E.

    2015-01-01

    Several recent United States (US) policies target spatial access to healthier food retailers. We evaluated two measures of community food access developed by two different agencies, using a 2009 food environment validation study in South Carolina as a reference. While the US Department of Agriculture Economic Research Service’s (USDA ERS) measure designated 22.5% of census tracts as food deserts, the Centers for Disease Control and Prevention’s (CDC) measure designated 29.0% as non-healthier retail tracts; 71% of tracts were designated consistently between USDA ERS and CDC. Our findings suggest a need for greater harmonization of these measures of community food access. PMID:26294937

  14. Web-accessible proteome databases for microbial research.

    PubMed

    Pleissner, Klaus-Peter; Eifert, Till; Buettner, Sven; Schmidt, Frank; Boehme, Martina; Meyer, Thomas F; Kaufmann, Stefan H E; Jungblut, Peter R

    2004-05-01

    The analysis of proteomes of biological organisms represents a major challenge of the post-genome era. Classical proteomics combines two-dimensional electrophoresis (2-DE) and mass spectrometry (MS) for the identification of proteins. Novel technologies such as isotope coded affinity tag (ICAT)-liquid chromatography/mass spectrometry (LC/MS) open new insights into protein alterations. The vast amount and diverse types of proteomic data require adequate web-accessible computational and database technologies for storage, integration, dissemination, analysis and visualization. A proteome database system (http://www.mpiib-berlin.mpg.de/2D-PAGE) for microbial research has been constructed which integrates 2-DE/MS, ICAT-LC/MS and functional classification data of proteins with genomic, metabolic and other biological knowledge sources. The two-dimensional polyacrylamide gel electrophoresis database delivers experimental data on microbial proteins including mass spectra for the validation of protein identification. The ICAT-LC/MS database comprises experimental data for protein alterations of mycobacterial strains BCG vs. H37Rv. By formulating complex queries within a functional protein classification database "FUNC_CLASS" for Mycobacterium tuberculosis and Helicobacter pylori the researcher can gather precise information on genes, proteins, protein classes and metabolic pathways. The use of the R language in the database architecture allows high-level data analysis and visualization to be performed "on-the-fly". The database system is centrally administrated, and investigators without specific bioinformatic competence in database construction can submit their data. The database system also serves as a template for a prototype of a European Proteome Database of Pathogenic Bacteria. Currently, the database system includes proteome information for six strains of microorganisms.

  15. 34 CFR 98.3 - Access to instructional material used in a research or experimentation program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Access to instructional material used in a research or... RIGHTS IN RESEARCH, EXPERIMENTAL PROGRAMS, AND TESTING § 98.3 Access to instructional material used in a research or experimentation program. (a) All instructional material—including teachers' manuals,...

  16. 22 CFR 171.24 - Access by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Access by historical researchers and certain... Access by historical researchers and certain former government personnel. (a) The restriction in E.O... engaged in historical research projects; (2) Have served as Presidential or Vice Presidential...

  17. 5 CFR 1312.24 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Access by historical researchers and... INFORMATION Control and Accountability of Classified Information § 1312.24 Access by historical researchers... may be waived for persons who are engaged in historical research projects, or who previously...

  18. 22 CFR 171.24 - Access by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Access by historical researchers and certain... Access by historical researchers and certain former government personnel. (a) The restriction in E.O... engaged in historical research projects; (2) Have served as Presidential or Vice Presidential...

  19. 5 CFR 1312.24 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Access by historical researchers and... INFORMATION Control and Accountability of Classified Information § 1312.24 Access by historical researchers... may be waived for persons who are engaged in historical research projects, or who previously...

  20. 5 CFR 1312.24 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Access by historical researchers and... INFORMATION Control and Accountability of Classified Information § 1312.24 Access by historical researchers... may be waived for persons who are engaged in historical research projects, or who previously...

  1. 22 CFR 171.24 - Access by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Access by historical researchers and certain... Access by historical researchers and certain former government personnel. (a) The restriction in E.O... engaged in historical research projects; (2) Have served as Presidential or Vice Presidential...

  2. 5 CFR 1312.24 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Access by historical researchers and... INFORMATION Control and Accountability of Classified Information § 1312.24 Access by historical researchers... may be waived for persons who are engaged in historical research projects, or who previously...

  3. 22 CFR 171.24 - Access by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Access by historical researchers and certain... Access by historical researchers and certain former government personnel. (a) The restriction in E.O... engaged in historical research projects; (2) Have served as Presidential or Vice Presidential...

  4. 5 CFR 1312.24 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Access by historical researchers and... INFORMATION Control and Accountability of Classified Information § 1312.24 Access by historical researchers... may be waived for persons who are engaged in historical research projects, or who previously...

  5. 22 CFR 171.24 - Access by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Access by historical researchers and certain... Access by historical researchers and certain former government personnel. (a) The restriction in E.O... engaged in historical research projects; (2) Have served as Presidential or Vice Presidential...

  6. 34 CFR 98.3 - Access to instructional material used in a research or experimentation program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Access to instructional material used in a research or... RIGHTS IN RESEARCH, EXPERIMENTAL PROGRAMS, AND TESTING § 98.3 Access to instructional material used in a research or experimentation program. (a) All instructional material—including teachers' manuals,...

  7. 32 CFR 1909.14 - Determinations on requests for access by historical researchers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... substantive government documents and/or information will be amenable to declassification and release and/or... Defense CENTRAL INTELLIGENCE AGENCY ACCESS BY HISTORICAL RESEARCHERS AND CERTAIN FORMER...

  8. 32 CFR 1909.14 - Determinations on requests for access by historical researchers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... substantive government documents and/or information will be amenable to declassification and release and/or... Defense CENTRAL INTELLIGENCE AGENCY ACCESS BY HISTORICAL RESEARCHERS AND CERTAIN FORMER...

  9. 32 CFR 1909.14 - Determinations on requests for access by historical researchers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... substantive government documents and/or information will be amenable to declassification and release and/or... Defense CENTRAL INTELLIGENCE AGENCY ACCESS BY HISTORICAL RESEARCHERS AND CERTAIN FORMER...

  10. Support of Research and Development Activities via the Internet: NASA's Access Mechanism.

    ERIC Educational Resources Information Center

    Duncan, Denise; And Others

    1993-01-01

    Describes a prototype information access system developed by NASA (National Aeronautics and Space Administration) called NAM (NASA Access Mechanism) to access the Internet for research and development activities. Topics addressed include the Science and Technical Information Program, information needs, networking requirements, functional and…

  11. Open access for operational research publications from low- and middle-income countries: who pays?

    PubMed

    Zachariah, R; Kumar, A M V; Reid, A J; Van den Bergh, R; Isaakidis, P; Draguez, B; Delaunois, P; Nagaraja, S B; Ramsay, A; Reeder, J C; Denisiuk, O; Ali, E; Khogali, M; Hinderaker, S G; Kosgei, R J; van Griensven, J; Quaglio, G L; Maher, D; Billo, N E; Terry, R F; Harries, A D

    2014-09-21

    Open-access journal publications aim to ensure that new knowledge is widely disseminated and made freely accessible in a timely manner so that it can be used to improve people's health, particularly those in low- and middle-income countries. In this paper, we briefly explain the differences between closed- and open-access journals, including the evolving idea of the 'open-access spectrum'. We highlight the potential benefits of supporting open access for operational research, and discuss the conundrum and ways forward as regards who pays for open access.

  12. Open access for operational research publications from low- and middle-income countries: who pays?

    PubMed Central

    Kumar, A. M. V.; Reid, A. J.; Van den Bergh, R.; Isaakidis, P.; Draguez, B.; Delaunois, P.; Nagaraja, S. B.; Ramsay, A.; Reeder, J. C.; Denisiuk, O.; Ali, E.; Khogali, M.; Hinderaker, S. G.; Kosgei, R. J.; van Griensven, J.; Quaglio, G. L.; Maher, D.; Billo, N. E.; Terry, R. F.; Harries, A. D.

    2014-01-01

    Open-access journal publications aim to ensure that new knowledge is widely disseminated and made freely accessible in a timely manner so that it can be used to improve people's health, particularly those in low- and middle-income countries. In this paper, we briefly explain the differences between closed- and open-access journals, including the evolving idea of the ‘open-access spectrum’. We highlight the potential benefits of supporting open access for operational research, and discuss the conundrum and ways forward as regards who pays for open access. PMID:26400799

  13. Research access to privately owned wetland basins in the prairie pothole region of the United States

    USGS Publications Warehouse

    Fellows, David P.; Buhl, Thomas K.

    1995-01-01

    We describe efforts to obtain access for research to 81 wetland basins on 69 farms in four zones of the Prairie Pothole Region of North Dakota, South Dakota, and Minnesota. Access was obtained to 54% of the farms in areas where land was intensively cropped and 87% of farms in areas of low cropping intensity. On average, 1.35 operators had to be contacted and 1.70 interviews were required to obtain a decision on access to a farm. On 77% of the farms, cooperators placed at least one restriction on access, most commonly requiring walking access only or notification before nighttime work. Cost of obtaining access averaged $265/farm in wages and travel expenses. No cooperators were willing to sign written access agreements. Operators rescinded access to four farms and drained three wetland basins during the first year; six of the seven sites lost were in the intensively cropped portion of a low-wetland-density zone. The difficulty of obtaining and retaining research access to privately owned wetland basins in intensively cropped areas may be related to landowner attitudes towards wetlands. Researchers may have to rely on remote sensing or consider payment for access to secure representative research sites in such areas. Unwillingness of cooperators to sign access agreements may jeopardize research by the newly formed National Biological Service and other resource management agencies.

  14. Prentice Medal Lecture 2013: Visual Accessibility: A Challenge for Low-Vision Research

    PubMed Central

    Legge, Gordon E.

    2014-01-01

    Low vision may be defined as any chronic form of vision impairment, not correctable by glasses or contact lenses, that adversely affects everyday function. Visual accessibility refers to factors that make an environment, device or display usable by vision. In this article, I discuss the concept of visual accessibility with special reference to low vision. What role can vision science play in enhancing visual accessibility for people with low vision? I propose that greater efforts to embed low-vision research in real-world contexts and collaboration with other disciplines will accelerate progress. I describe examples from my current research projects on architectural accessibility and reading accessibility. PMID:24978657

  15. Prentice medal lecture 2013: visual accessibility: a challenge for low-vision research.

    PubMed

    Legge, Gordon E

    2014-07-01

    Low vision may be defined as any chronic form of vision impairment, not correctable by glasses or contact lenses, that adversely affects everyday function. Visual accessibility refers to factors that make an environment, device, or display usable by vision. In this article, I discuss the concept of visual accessibility with special reference to low vision. What role can vision science play in enhancing visual accessibility for people with low vision? I propose that greater efforts to embed low-vision research in real-world contexts and collaboration with other disciplines will accelerate progress. I describe examples from my current research projects on architectural accessibility and reading accessibility.

  16. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

    PubMed

    Polier, Sigrun; Samant, Rahul S; Clarke, Paul A; Workman, Paul; Prodromou, Chrisostomos; Pearl, Laurence H

    2013-05-01

    Protein kinase clients are recruited to the Hsp90 molecular chaperone system via Cdc37, which simultaneously binds Hsp90 and kinases and regulates the Hsp90 chaperone cycle. Pharmacological inhibition of Hsp90 in vivo results in degradation of kinase clients, with a therapeutic effect in dependent tumors. We show here that Cdc37 directly antagonizes ATP binding to client kinases, suggesting a role for the Hsp90-Cdc37 complex in controlling kinase activity. Unexpectedly, we find that Cdc37 binding to protein kinases is itself antagonized by ATP-competitive kinase inhibitors, including vemurafenib and lapatinib. In cancer cells, these inhibitors deprive oncogenic kinases such as B-Raf and ErbB2 of access to the Hsp90-Cdc37 complex, leading to their degradation. Our results suggest that at least part of the efficacy of ATP-competitive inhibitors of Hsp90-dependent kinases in tumor cells may be due to targeted chaperone deprivation.

  17. Teachers and Access to Schooling in Ghana. CREATE Pathways to Access. Research Monograph No. 43

    ERIC Educational Resources Information Center

    Alhassan, Seidu; Adzahlie-Mensah, Vincent

    2010-01-01

    This paper provides insights about the specific impact teachers' actions and attitudes can have on access to schooling. The paper reports how teachers' irregular attendance, lateness and absenteeism as well as misuse of instructional hours and indiscriminate use of corporal punishment contribute to pupils' irregular attendance and dropping out. It…

  18. Access to What? Access, Diversity and Participation in India's Schools. Research Monograph No. 32

    ERIC Educational Resources Information Center

    Juneja, Nalini

    2010-01-01

    India has witnessed substantial diversification of provision to basic education. Policy changes from 1980s onwards, has seen the creation of para-formal delivery systems and the inclusion in the system of non state providers. The Education Guarantee Scheme and the Alternate Initiatives in Education programmes have generated new pathways to access.…

  19. Access to Archived Astronaut Data for Human Research Program Researchers: Update on Progress and Process Improvements

    NASA Technical Reports Server (NTRS)

    Lee, L. R.; Montague, K. A.; Charvat, J. M.; Wear, M. L.; Thomas, D. M.; Van Baalen, M.

    2016-01-01

    Since the 2010 NASA directive to make the Life Sciences Data Archive (LSDA) and Lifetime Surveillance of Astronaut Health (LSAH) data archives more accessible by the research and operational communities, demand for astronaut medical data has increased greatly. LSAH and LSDA personnel are working with Human Research Program on many fronts to improve data access and decrease lead time for release of data. Some examples include the following: Feasibility reviews for NASA Research Announcement (NRA) data mining proposals; Improved communication, support for researchers, and process improvements for retrospective Institutional Review Board (IRB) protocols; Supplemental data sharing for flight investigators versus purely retrospective studies; Work with the Multilateral Human Research Panel for Exploration (MHRPE) to develop acceptable data sharing and crew consent processes and to organize inter-agency data coordinators to facilitate requests for international crewmember data. Current metrics on data requests crew consenting will be presented, along with limitations on contacting crew to obtain consent. Categories of medical monitoring data available for request will be presented as well as flow diagrams detailing data request processing and approval steps.

  20. A Machine-Portable CDC UPDATE Emulator.

    SciTech Connect

    THOMAS,; HAILL, A.

    1987-09-01

    Version 01 UPEML is a machine-portable CDC UPDATE emulation program. It is capable of emulating a significant subset of the standard CDC UPDATE functions, including program library creation and subsequent modification.

  1. CDC 2004 Programs in Brief.

    ERIC Educational Resources Information Center

    US Department of Health and Human Services, 2004

    2004-01-01

    Grouped in 16 categories, the 2004 Programs in Brief illustrates the scope of Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR) activities, as well as their shared goals of safer, healthier people here and around the world. Each description includes a statement of the public health…

  2. Introducing Open Highlights: Highlighting Open Access Research from PLOS and Beyond.

    PubMed

    2016-07-01

    PLOS Biology announces a new article type, Open Highlights, which uses a recent research article to nucleate a short synthesis of up to ten related research articles from other PLOS journals and from the wider Open Access corpus.

  3. Introducing Open Highlights: Highlighting Open Access Research from PLOS and Beyond.

    PubMed

    2016-07-01

    PLOS Biology announces a new article type, Open Highlights, which uses a recent research article to nucleate a short synthesis of up to ten related research articles from other PLOS journals and from the wider Open Access corpus. PMID:27400228

  4. 45 CFR 601.9 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Access by historical researchers and former Presidential appointees. 601.9 Section 601.9 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CLASSIFICATION AND DECLASSIFICATION OF NATIONAL SECURITY INFORMATION § 601.9 Access by historical researchers...

  5. 34 CFR 98.3 - Access to instructional material used in a research or experimentation program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Access to instructional material used in a research or experimentation program. 98.3 Section 98.3 Education Office of the Secretary, Department of Education STUDENT RIGHTS IN RESEARCH, EXPERIMENTAL PROGRAMS, AND TESTING § 98.3 Access to instructional material used in...

  6. 34 CFR 98.3 - Access to instructional material used in a research or experimentation program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Access to instructional material used in a research or experimentation program. 98.3 Section 98.3 Education Office of the Secretary, Department of Education STUDENT RIGHTS IN RESEARCH, EXPERIMENTAL PROGRAMS, AND TESTING § 98.3 Access to instructional material used in...

  7. Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance

    PubMed Central

    Mason, Mark; Wanat, Jennifer J.; Harper, Sandy; Schultz, David C.; Speicher, David W.; Johnson, F. Brad; Skordalakes, Emmanuel

    2012-01-01

    SUMMARY Cdc13 is an essential yeast protein required for telomere length regulation and genome stability. It does so via its telomere capping properties and by regulating telomerase access to the telomeres. The crystal structure of the S. cerevisiae Cdc13 domain located between the recruitment and DNA binding domains reveals an oligonucleotide-oligosaccharide binding fold (OB2) with unusually long loops extending from the core of the protein. These loops are involved in extensive interactions between two Cdc13 OB2 folds leading to stable homo-dimerization. Interestingly, the functionally impaired cdc13-1 mutation inhibits OB2 dimerization. Biochemical assays indicate OB2 is not involved in telomeric DNA or Stn1 binding. However, disruption of the OB2 dimer in full-length Cdc13 affects Cdc13-Stn1 association leading to telomere length deregulation, increased temperature sensitivity and Stn1 binding defects. We therefore propose that dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping. PMID:23177925

  8. Gaining Access: A Practical and Theoretical Guide for Qualitative Researchers.

    ERIC Educational Resources Information Center

    Feldman, Martha S.; Bell, Jeannine; Berger, Michele Tracy

    This book offers useful, prescriptive advice on how to enter different field settings for interviewing and observation. The chapters of part 1, "Stages of Access," are: (1) "Finding Informants"; (2) "Human Subjects and Permission To Contact Informants"; (3) "Making Initial Contact"; (4) "Developing a Rapport"; and (5) "Exiting: Ending the…

  9. The Academic Ethics of Open Access to Research and Scholarship

    ERIC Educational Resources Information Center

    Willinsky, John; Alperin, Juan Pablo

    2011-01-01

    In this article, we present the case for regarding the principles by which scholarly publications are disseminated and shared as a matter of academic ethics. The ethics of access have to do with recognizing people's right to know what is known, as well as the value to humanity of having one of its best forms of arriving at knowledge as widely…

  10. Reflections and Recommendations Based on a Migrant Health Center's Participation in a CDC Study.

    ERIC Educational Resources Information Center

    Nolon, Anne K.; O'Barr, James

    Hudson Valley Migrant Health (HVMH) (a Public Health Service program) collaborated with the Center for Disease Control (CDC) and the New York State Department of Health (NYSDOH) on a study of the incidence of sexually transmitted diseases and tuberculosis among migrant farmworkers in the mid-Hudson region of New York. CDC research personnel…

  11. Beacon interacts with cdc2/cdc28-like kinases.

    PubMed

    Kantham, Lakshmi; Kerr-Bayles, Lyndal; Godde, Nathan; Quick, Melissa; Webb, Ryan; Sunderland, Terry; Bond, Judy; Walder, Ken; Augert, Guy; Collier, Greg

    2003-04-25

    Previously we found elevated beacon gene expression in the hypothalamus of obese Psammomys obesus. Beacon administration into the lateral ventricle of P. obesus stimulated food intake and body weight gain. In the current study we used yeast two-hybrid technology to screen for proteins in the human brain that interact with beacon. CLK4, an isoform of cdc2/cdc28-like kinase family of proteins, was identified as a strong interacting partner for beacon. Using active recombinant proteins and a surface plasmon resonance based detection technique, we demonstrated that the three members of this subfamily of kinases (CLK1, 2, and 4) all interact with beacon. Based on the known sequence and functional properties of beacon and CLKs, we speculate that beacon could either modulate the function of key regulatory molecules such as PTP1B or control the expression patterns of specific genes involved in the central regulation of energy metabolism.

  12. Increasing Access to Atmospheric Science Research at NASA Langley Research Center

    NASA Astrophysics Data System (ADS)

    Chambers, L. H.; Bethea, K. L.; LaPan, J. C.

    2013-12-01

    The Science Directorate (SD) at NASA's Langley Research Center conducts cutting edge research in fundamental atmospheric science topics including radiation and climate, air quality, active remote sensing, and upper atmospheric composition. These topics matter to the public, as they improve our understanding of our home planet. Thus, we have had ongoing efforts to improve public access to the results of our research. These efforts have accelerated with the release of the February OSTP memo. Our efforts can be grouped in two main categories: 1. Visual presentation techniques to improve science understanding: For fundamental concepts such as the Earth's energy budget, we have worked to display information in a more "digestible" way for lay audiences with more pictures and fewer words. These audiences are iPad-lovers and TV-watchers with shorter attention spans than audiences of the past. They are also educators and students who need a basic understanding of a concept delivered briefly to fit into busy classroom schedules. We seek to reach them with a quick, visual message packed with important information. This presentation will share several examples of visual techniques, such as infographics (e.g., a history of lidar at Langley and a timeline of atmospheric research, ozone garden diagrams (http://science-edu.larc.nasa.gov/ozonegarden/ozone-cycle.php); history of lidar at LaRC; DISCOVER-AQ maps. It will also share examples of animations and interactive graphics (DISCOVER-AQ); and customized presentations (e.g., to explain the energy budget or to give a general overview of research). One of the challenges we face is a required culture shift between the way scientists traditionally share knowledge with each other and the way these public audiences ingest knowledge. A cross-disciplinary communications team in SD is crucial to bridge that gap. 2. Lay research summaries to make research more accessible: Peer-reviewed publications are a primary product of the SD, with more

  13. When are food deserts? Integrating time into research on food accessibility.

    PubMed

    Widener, Michael J; Shannon, Jerry

    2014-11-01

    The food desert concept is used as a means for defining regions as having inadequate spatial and socioeconomic access to vendors selling nutritious foods. This primarily aggregate-level and static method for understanding the food environment is commonly used by researchers and policy makers seeking to improve health outcomes of those affected by reduced access. However, recent research findings have brought the association between living in a food desert and adverse health outcomes into question. In this viewpoint, we put forward the idea that the food desert concept, and food accessibility research more generally, should be expanded to include a temporal component, and note potential avenues for future research.

  14. Recent Developments in Alcohol Services Research on Access to Care.

    PubMed

    Schmidt, Laura A

    2016-01-01

    In the United States, only about 10 percent of people with an alcohol or drug use disorder receive care for the condition, pointing to a large treatment gap. Several personal characteristics influence whether a person will receive treatment; additionally, many people with an alcohol use disorder do not perceive the need for treatment. The extent of the treatment gap differs somewhat across different population subgroups, such as those based on gender, age, or race and ethnicity. Recent health care reforms, such as implementation of the Patient Protection and Affordable Care Act of 2010, likely will improve access to substance abuse treatment. In addition, new treatment approaches, service delivery systems, and payment innovations may facilitate access to substance abuse services. Nevertheless, efforts to bridge the treatment gap will continue to be needed to ensure that all people who need alcohol and drug abuse treatment can actually receive it. PMID:27159809

  15. Recent Developments in Alcohol Services Research on Access to Care

    PubMed Central

    Schmidt, Laura A.

    2016-01-01

    In the United States, only about 10 percent of people with an alcohol or drug use disorder receive care for the condition, pointing to a large treatment gap. Several personal characteristics influence whether a person will receive treatment; additionally, many people with an alcohol use disorder do not perceive the need for treatment. The extent of the treatment gap differs somewhat across different population subgroups, such as those based on gender, age, or race and ethnicity. Recent health care reforms, such as implementation of the Patient Protection and Affordable Care Act of 2010, likely will improve access to substance abuse treatment. In addition, new treatment approaches, service delivery systems, and payment innovations may facilitate access to substance abuse services. Nevertheless, efforts to bridge the treatment gap will continue to be needed to ensure that all people who need alcohol and drug abuse treatment can actually receive it. PMID:27159809

  16. Research on immune storage anomaly detection via user access behavior

    NASA Astrophysics Data System (ADS)

    Huang, Jianzhong; Chen, Yunliang; Fang, Yunfu

    2008-12-01

    If an intruder uses a stolen account, the authentication sub-system will regard the intruder as a legitimate user. In order to filter out such illegal users, the storage system should be capable of the user activity diagnosis. This paper presents a novel anomaly detection scheme to monitor the user access activities using the artificial immune technique. When an access request violates the access control rule, it is regarded as Non-self, so as to provide some early warning tips to the storage security sub-system. Compared with the NIDS, the proposed scheme targets the anomaly detection at storage level and focuses on the read/write data requests. In the prophase of simulation, a set of optimal parameters of algorithm are fitted according to the mean convergence speed and detection efficiency. The simulation shows the proposed scheme can reach rather high detection rate and low false alarm rate, further validating its feasibility. Thus the storage anomaly detection would strengthen the storage early warning and improve the storage security.

  17. 36 CFR 1256.80 - How does NARA provide classified access to historical researchers and former Presidential...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... provided in 36 CFR part 1254. ... classified access to historical researchers and former Presidential appointees? 1256.80 Section 1256.80 Parks... ACCESS TO RECORDS AND DONATED HISTORICAL MATERIALS Access to Materials Containing National...

  18. 36 CFR 1256.80 - How does NARA provide classified access to historical researchers and former Presidential...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... provided in 36 CFR part 1254. ... classified access to historical researchers and former Presidential appointees? 1256.80 Section 1256.80 Parks... ACCESS TO RECORDS AND DONATED HISTORICAL MATERIALS Access to Materials Containing National...

  19. Accessible Article: Involving People with Learning Disabilities in Research

    ERIC Educational Resources Information Center

    Garbutt, Ruth; Tattersall, John; Dunn, Jo; Boycott-Garnett, Rachel

    2010-01-01

    This is an article that talks about our research about sex and relationships for people with learning disabilities. It talks about how people with learning disabilities have been fully involved in the research. (Contains 2 footnotes.)

  20. Restricting access to publications from funded research: ethical issues and solutions.

    PubMed

    Manikandan, S; Vani, N Isai

    2010-01-01

    India is becoming one of the hubs of clinical research. Commensurate with these advances, the government funding for biomedical research in thrust areas is also increasing. The Indian Council of Medical Research (ICMR), Department of Biotechnology (DBT), Department of Science and Technology (DST) are some of the government organizations which provide financial support for various research projects. The results of the funded research projects are published in various international journals. Most of these journals have an access to paid subscribers only. Hence it is unethical to use the research grants from government (people's money) and not allow the scientific community free access to the results of the study. To tackle such issues, these agencies should sign the Berlin declaration and create open access repositories. A public access policy should be formulated and listed in JULIET. The funding bodies in India should also join Pubmed Central (PMC) to form PMC India so that every investigator who has received grants would submit the full text of the paper published from his study and these can be made freely accessible to everyone. Universities and research institutions should also develop institutional open access repositories. The public access policy has definitive advantages and should be implemented. PMID:20622399

  1. Restricting access to publications from funded research: ethical issues and solutions.

    PubMed

    Manikandan, S; Vani, N Isai

    2010-01-01

    India is becoming one of the hubs of clinical research. Commensurate with these advances, the government funding for biomedical research in thrust areas is also increasing. The Indian Council of Medical Research (ICMR), Department of Biotechnology (DBT), Department of Science and Technology (DST) are some of the government organizations which provide financial support for various research projects. The results of the funded research projects are published in various international journals. Most of these journals have an access to paid subscribers only. Hence it is unethical to use the research grants from government (people's money) and not allow the scientific community free access to the results of the study. To tackle such issues, these agencies should sign the Berlin declaration and create open access repositories. A public access policy should be formulated and listed in JULIET. The funding bodies in India should also join Pubmed Central (PMC) to form PMC India so that every investigator who has received grants would submit the full text of the paper published from his study and these can be made freely accessible to everyone. Universities and research institutions should also develop institutional open access repositories. The public access policy has definitive advantages and should be implemented.

  2. Mobilising Open Access to Research Data: Recommendations from the RECODE project

    NASA Astrophysics Data System (ADS)

    Finn, Rachel; Sveinsdottir, Thordis

    2015-04-01

    This paper will introduce the findings and policy recommendations from the FP7 project RECODE (Policy RECommendations for Open Access to Research Data in Europe) which aims to leverage existing networks, communities and projects to address challenges within the open access and data dissemination and preservation sector. We will introduce the key recommendations, which provide solutions relevant to opening access to PSI. The project is built on case study research of five scientific disciplines with the aim of recognizing and working with disciplinary fragmentation associated with open access to research data. The RECODE findings revealed that the mobilisation of open access to research data requires a partnership approach for developing a coherent and flexible ecosystem that is easy and transparent to embed in research practice and process. As such, the development of open access to research data needs to be: • Informed by research practices and processes in different fields • Supported by an integrated institutional and technological data infrastructure and guided by ethical and regulatory frameworks • Underpinned by infrastructure and guiding frameworks that allow for differences in disciplinary research and data management practices • Characterised by a partnership approach involving the key stakeholders, researchers, and institutions The proposed presentation will examine each of these aspects in detail and use information and good practices from the RECODE project to consider how stakeholders within the PSI movement might action each of these points. It will also highlight areas where RECODE findings and good practice recommendations have clear relevance for the PSI sector.

  3. Accessing User Facilities and Making your Research Experience Successful

    SciTech Connect

    Reeder,R.; Lanzirotti, A.

    2006-01-01

    Access to many of the world's leading user facilities is easier than ever before, with web-based tutorials providing everything from instrumental overviews and example applications to online safety training. Submission of proposals for experiment time at large, heavily subscribed facilities, including synchrotron and neutron sources, has been streamlined with web-based submission. Support, which is commonly the key to successful experiments, is provided by facility staff and experienced users, allowing new users to begin experiments with minimal experience. Increasingly Earth scientists are taking advantage of the wide range of unique instrumentation at user facilities. Here, we explain how you can, too.

  4. Government databases and public health research: facilitating access in the public interest.

    PubMed

    Adams, Carolyn; Allen, Judy

    2014-06-01

    Access to datasets of personal health information held by government agencies is essential to support public health research and to promote evidence-based public health policy development. Privacy legislation in Australia allows the use and disclosure of such information for public health research. However, access is not always forthcoming in a timely manner and the decision-making process undertaken by government data custodians is not always transparent. Given the public benefit in research using these health information datasets, this article suggests that it is time to recognise a right of access for approved research and that the decisions, and decision-making processes, of government data custodians should be subject to increased scrutiny. The article concludes that researchers should have an avenue of external review where access to information has been denied or unduly delayed.

  5. Embedding Accessibility and Usability: Considerations for E-Learning Research and Development Projects

    ERIC Educational Resources Information Center

    Cooper, Martyn; Colwell, Chetz; Jelfs, Anne

    2007-01-01

    This paper makes the case that if e-learning research and development projects are to be successfully adopted in real-world teaching and learning contexts, then they must effectively address accessibility and usability issues; and that these need to be integrated throughout the project. As such, accessibility and usability issues need to be made…

  6. AGU Journals Are Compliant With Research Councils UK Open Access Policies

    NASA Astrophysics Data System (ADS)

    Hanson, Brooks

    2013-04-01

    The Research Councils UK (RCUK) has mandated that after 1 April 2013, papers with RCUK funding be submitted to journals that are compliant with its open-access policy. This policy requires "immediate and unrestricted access to the final published version of papers" and use of the Creative Commons Attribution License (known as CC-BY). Copyright remains with the authors.

  7. Frameworks for Making Science Research Accessible for All

    ERIC Educational Resources Information Center

    Chien, Annie; Karlich, Lisa

    2007-01-01

    Science teachers embrace environments that foster inquiry, discovery and critical thinking. Students do authentic independent research projects that put them in the role of scientists. At School of the Future (SOF), students must do four research projects, also known as exhibitions, as a part of their graduation requirements. Students are expected…

  8. Extension Clientele Preferences: Accessing Research-Based Information Online

    ERIC Educational Resources Information Center

    Davis, Jamie M.

    2014-01-01

    Research has indicated there are a number of benefits to Extension educators in delivering educational program and content through distance technology methods. However, Extension educators are commonly apprehensive about this transition due to assumptions made about their clientele, because little research has been conducted to examine…

  9. Functional characterization and cellular dynamics of the CDC-42 - RAC - CDC-24 module in Neurospora crassa.

    PubMed

    Araujo-Palomares, Cynthia L; Richthammer, Corinna; Seiler, Stephan; Castro-Longoria, Ernestina

    2011-01-01

    Rho-type GTPases are key regulators that control eukaryotic cell polarity, but their role in fungal morphogenesis is only beginning to emerge. In this study, we investigate the role of the CDC-42 - RAC - CDC-24 module in Neurospora crassa. rac and cdc-42 deletion mutants are viable, but generate highly compact colonies with severe morphological defects. Double mutants carrying conditional and loss of function alleles of rac and cdc-42 are lethal, indicating that both GTPases share at least one common essential function. The defects of the GTPase mutants are phenocopied by deletion and conditional alleles of the guanine exchange factor (GEF) cdc-24, and in vitro GDP-GTP exchange assays identify CDC-24 as specific GEF for both CDC-42 and RAC. In vivo confocal microscopy shows that this module is organized as membrane-associated cap that covers the hyphal apex. However, the specific localization patterns of the three proteins are distinct, indicating different functions of RAC and CDC-42 within the hyphal tip. CDC-42 localized as confined apical membrane-associated crescent, while RAC labeled a membrane-associated ring excluding the region labeled by CDC42. The GEF CDC-24 occupied a strategic position, localizing as broad apical membrane-associated crescent and in the apical cytosol excluding the Spitzenkörper. RAC and CDC-42 also display distinct localization patterns during branch initiation and germ tube formation, with CDC-42 accumulating at the plasma membrane before RAC. Together with the distinct cellular defects of rac and cdc-42 mutants, these localizations suggest that CDC-42 is more important for polarity establishment, while the primary function of RAC may be maintaining polarity. In summary, this study identifies CDC-24 as essential regulator for RAC and CDC-42 that have common and distinct functions during polarity establishment and maintenance of cell polarity in N. crassa.

  10. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair

    PubMed Central

    Lin, Han; Ha, Kyungsoo; Lu, Guojun; Fang, Xiao; Cheng, Ranran; Zuo, Qiuhong

    2015-01-01

    Cdc14 is a phosphatase that controls mitotic exit and cytokinesis in budding yeast. In mammals, the two Cdc14 homologues, Cdc14A and Cdc14B, have been proposed to regulate DNA damage repair, whereas the mitotic exit and cytokinesis rely on another phosphatase, PP2A-B55α. It is unclear if the two Cdc14s work redundantly in DNA repair and which repair pathways they participate in. More importantly, their target(s) in DNA repair remains elusive. Here we report that Cdc14B knockout (Cdc14B−/−) mouse embryonic fibroblasts (MEFs) showed defects in repairing ionizing radiation (IR)-induced DNA double-strand breaks (DSBs), which occurred only at late passages when Cdc14A levels were low. This repair defect could occur at early passages if Cdc14A levels were also compromised. These results indicate redundancy between Cdc14B and Cdc14A in DSB repair. Further, we found that Cdc14B deficiency impaired both homologous recombination (HR) and nonhomologous end joining (NHEJ), the two major DSB repair pathways. We also provide evidence that Cdh1 is a downstream target of Cdc14B in DSB repair. PMID:26283732

  11. Improved Access to NSF Funded Ocean Research Data

    NASA Astrophysics Data System (ADS)

    Chandler, C. L.; Groman, R. C.; Kinkade, D.; Shepherd, A.; Rauch, S.; Allison, M. D.; Gegg, S. R.; Wiebe, P. H.; Glover, D. M.

    2015-12-01

    Data from NSF-funded, hypothesis-driven research comprise an essential part of the research results upon which we base our knowledge and improved understanding of the impacts of climate change. Initially funded in 2006, the Biological and Chemical Oceanography Data Management Office (BCO-DMO) works with marine scientists to ensure that data from NSF-funded ocean research programs are fully documented and freely available for future use. BCO-DMO works in partnership with information technology professionals, other marine data repositories and national data archive centers to ensure long-term preservation of these valuable environmental research data. Data contributed to BCO-DMO by the original investigators are enhanced with sufficient discipline-specific documentation and published in a variety of standards-compliant forms designed to enable discovery and support accurate re-use.

  12. The impact of free access to the scientific literature: a review of recent research

    PubMed Central

    Walters, William H

    2011-01-01

    Objectives: The paper reviews recent studies that evaluate the impact of free access (open access) on the behavior of scientists as authors, readers, and citers in developed and developing nations. It also examines the extent to which the biomedical literature is used by the general public. Method: The paper is a critical review of the literature, with systematic description of key studies. Results: Researchers report that their access to the scientific literature is generally good and improving. For authors, the access status of a journal is not an important consideration when deciding where to publish. There is clear evidence that free access increases the number of article downloads, although its impact on article citations is not clear. Recent studies indicate that large citation advantages are simply artifacts of the failure to adequately control for confounding variables. The effect of free access on the general public's use of the primary medical literature has not been thoroughly evaluated. Conclusions: Recent studies provide little evidence to support the idea that there is a crisis in access to the scholarly literature. Further research is needed to investigate whether free access is making a difference in non-research contexts and to better understand the dissemination of scientific literature through peer-to-peer networks and other informal mechanisms. PMID:21753913

  13. Summary and findings of the EPA and CDC symposium on air pollution exposure and health.

    PubMed

    Ozkaynak, Halûk; Glenn, Barbara; Qualters, Judith R; Strosnider, Heather; McGeehin, Michael A; Zenick, Harold

    2009-01-01

    The U.S. Environmental Protection Agency (EPA) and the U.S. Centers for Disease Control (CDC) co-organized a symposium on "Air Pollution Exposure and Health" at Research Triangle Park, North Carolina on September 19-20, 2006. The symposium brought together health and environmental scientists to discuss the state of the science and the cross-jurisdictional and methodological challenges in conducting air pollution epidemiology, environmental public health tracking and accountability research. The symposium was held over 2 days and consisted of technical presentations and breakout group discussions on each of the three principal themes of this meeting: (1) monitoring and exposure modeling information, (2) health effects data and (3) linkage of air quality and health data for research, tracking and accountability. This paper summarizes the symposium presentations and the conclusions and recommendations developed during the meeting. The accompanying two papers, which appear in this issue of the Journal, provide more in-depth discussion of issues pertinent to obtaining and analyzing air pollution exposure and health information. The symposium succeeded in identifying areas where there are critical gaps of knowledge in existing air pollution exposure and health information and in discovering institutional or programmatic barriers, which impede accessing and linking disparate data sets. Several suggestions and recommendations emerged from this meeting, directed toward (1) improving the utility of air monitoring data for exposure quantification, (2) improving access to and the quality of health data, (3) studying emerging air quality and health issues, (4) exploring improved or novel methods for linking data and (5) developing partnerships, building capacity and facilitating interdisciplinary communication. The meeting was successful in promoting an interdisciplinary dialogue around these issues and in formulating strategies to support these recommended activities. Finally

  14. Paradigms and poverty in global energy policy: research needs for achieving universal energy access

    NASA Astrophysics Data System (ADS)

    Sovacool, Benjamin K.; Bazilian, Morgan; Toman, Michael

    2016-06-01

    This research letter discusses elements of a long-term interdisciplinary research effort needed to help ensure the maximum social, economic, and environmental benefits of achieving secure universal access to modern energy services. Exclusion of these services affects the lives and livelihoods of billions of people. The research community has an important, but not yet well-defined, role to play.

  15. 49 CFR 8.29 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... branch who are engaged in historical research projects may have access to classified information provided... to persons who are conducting historical research as private individuals or under private sponsorship and do not apply to research conducted under Government contract or sponsorship. The provisions...

  16. CDC20 maintains tumor initiating cells

    PubMed Central

    Xie, Qi; Wu, Qiulian; Mack, Stephen C.; Yang, Kailin; Kim, Leo; Hubert, Christopher G.; Flavahan, William A.; Chu, Chengwei; Bao, Shideng; Rich, Jeremy N.

    2015-01-01

    Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor. Glioblastoma displays hierarchical arrangement with a population of self-renewing and tumorigenic glioma tumor initiating cells (TICs), or cancer stem cells. While non-neoplastic neural stem cells are generally quiescent, glioblastoma TICs are often proliferative with mitotic control offering a potential point of fragility. Here, we interrogate the role of cell-division cycle protein 20 (CDC20), an essential activator of anaphase-promoting complex (APC) E3 ubiquitination ligase, in the maintenance of TICs. By chromatin analysis and immunoblotting, CDC20 was preferentially expressed in TICs relative to matched non-TICs. Targeting CDC20 expression by RNA interference attenuated TIC proliferation, self-renewal and in vivo tumor growth. CDC20 disruption mediated its effects through induction of apoptosis and inhibition of cell cycle progression. CDC20 maintains TICs through degradation of p21CIP1/WAF1, a critical negative regulator of TICs. Inhibiting CDC20 stabilized p21CIP1/WAF1, resulting in repression of several genes critical to tumor growth and survival, including CDC25C, c-Myc and Survivin. Transcriptional control of CDC20 is mediated by FOXM1, a central transcription factor in TICs. These results suggest CDC20 is a critical regulator of TIC proliferation and survival, linking two key TIC nodes – FOXM1 and p21CIP1/WAF1 — elucidating a potential point for therapeutic intervention. PMID:25938542

  17. Museum Accessibility: Combining Audience Research and Staff Training

    ERIC Educational Resources Information Center

    Levent, Nina; Reich, Christine

    2013-01-01

    This article discusses an audience-informed professional development model that combines audience research focus groups and staff training that includes interaction and direct feedback from visitors, in this case, visitors with low vision. There are two critical components to this model: one is that museums' programming decisions are informed by…

  18. Emerging technologies and web accessibility: research challenges and opportunities focussing on vision issues.

    PubMed

    Harper, Simon; Yesilada, Yeliz

    2012-01-01

    This is a technological review paper focussed on identifying both the research challenges and opportunities for further investigation arising from emerging technologies, and it does not aim to propose any recommendation or standard. It is focussed on blind and partially sighted World Wide Web (Web) users along with others who use assistive technologies. The Web is a fast moving interdisciplinary domain in which new technologies, techniques and research is in perpetual development. It is often difficult to maintain a holistic view of new developments within the multiple domains which together make up the Web. This suggests that knowledge of the current developments and predictions of future developments are additionally important for the accessibility community. Web accessibility has previously been characterised by the correction of our past mistakes to make the current Web fulfil the original vision of access for all. New technologies were not designed with accessibility in mind and technologies that could be useful for addressing accessibility issues were not identified or adopted by the accessibility community. We wish to enable the research community to undertake preventative measures and proactively address challenges, while recognising opportunities, before they become unpreventable or require retrospective technological enhancement. This article then reviews emerging trends within the Web and Web Accessibility domains.

  19. CDC Health Disparities and Inequalities Report--U.S. 2013

    MedlinePlus

    ... to Community Health Tribal Support Women's Health CDC Health Disparities & Inequalities Report (CHDIR) Recommend on Facebook Tweet Share Compartir ... Sheets 2011 Report More Information CDC Releases Second Health Disparities & Inequalities Report - United States, 2013 CDC and its partners ...

  20. CDC Vital Signs: More People Walk to Better Health

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  1. CDC Vital Signs: Adult Smoking among People with Mental Illness

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  2. CDC Vital Signs: Preventing Pregnancies in Younger Teens

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  3. CDC Vital Signs: Prescription Painkiller Overdoses in the US

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  4. CDC Vital Signs: High Blood Pressure and Cholesterol

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  5. CDC Vital Signs: Reducing Sodium in Children's Diets

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  6. CDC Vital Signs: Making Food Safer to Eat

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  7. CDC Vital Signs: Colorectal Cancer Tests Save Lives

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  8. Uriel Cohen, Tim McGinty, Gary T. Moore, CDC Inc. and Center for Architecture and Urban Planning Research, University of Wisconsin-Milwaukee.

    ERIC Educational Resources Information Center

    Progressive Architecture, 1979

    1979-01-01

    A P/A citation for research was given for this report, the initial step in a U.S. Army project to improve child care facilities and play areas at military establishments around the country. The report evaluates 50 child care and play environments. (Author/MLF)

  9. 13 CFR 120.822 - CDC membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC membership. 120.822 Section 120.822 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development... prior to January 1, 1987). The CDC membership must meet annually. No person or entity can own or...

  10. International Development and Research Capacities: Increasing Access to African Scholarly Publishing

    ERIC Educational Resources Information Center

    Metcalfe, Amy Scott; Esseh, Samuel; Willinsky, John

    2009-01-01

    This paper examines the evolving relationship between Canada and the African academic research community through the promotion of a concept known as Information and Communication Technology for Development (ICT4D) and with an eye to its implications for increasing the circulation of research through such means as open access (OA) publishing…

  11. MaizeGDB: enabling access to basic, translational, and applied research information

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MaizeGDB is the Maize Genetics and Genomics Database (available online at http://www.maizegdb.org). The MaizeGDB project is not simply an online database and website but rather an information service to maize researchers that supports customized data access and analysis needs to individual research...

  12. Access to Essential Medicines in Pakistan: Policy and Health Systems Research Concerns

    PubMed Central

    Zaidi, Shehla; Bigdeli, Maryam; Aleem, Noureen; Rashidian, Arash

    2013-01-01

    Introduction Inadequate access to essential medicines is a common issue within developing countries. Policy response is constrained, amongst other factors, by a dearth of in-depth country level evidence. We share here i) gaps related to access to essential medicine in Pakistan; and ii) prioritization of emerging policy and research concerns. Methods An exploratory research was carried out using a health systems perspective and applying the WHO Framework for Equitable Access to Essential Medicine. Methods involved key informant interviews with policy makers, providers, industry, NGOs, experts and development partners, review of published and grey literature, and consultative prioritization in stakeholder’s Roundtable. Findings A synthesis of evidence found major gaps in essential medicine access in Pakistan driven by weaknesses in the health care system as well as weak pharmaceutical regulation. 7 major policy concerns and 11 emerging research concerns were identified through consultative Roundtable. These related to weaknesses in medicine registration and quality assurance systems, unclear and counterproductive pricing policies, irrational prescribing and sub-optimal drug availability. Available research, both locally and globally, fails to target most of the identified policy concerns, tending to concentrate on irrational prescriptions. It overlooks trans-disciplinary areas of policy effectiveness surveillance, consumer behavior, operational pilots and pricing interventions review. Conclusion Experience from Pakistan shows that policy concerns related to essential medicine access need integrated responses across various components of the health systems, are poorly addressed by existing evidence, and require an expanded health systems research agenda. PMID:23717442

  13. [Therapeutic uses of investigational drugs: research extension, compassionate use, and expanded access].

    PubMed

    Goldim, José Roberto

    2008-03-01

    This article describes the methodological, regulatory, and ethical aspects of the different therapeutic uses of investigational drugs--research extension, compassionate use, and expanded access. Worldwide, the principle challenges of this kind of treatment are: setting minimum quality standards for researchers, as well as institutions, so that projects can include drugs at various stages of development; training of evaluation and assessment committees on the methodological, regulatory, and ethical aspects of new drug research; clearly outlining the relationship between researchers and funding organizations and between researchers and study participants; and understanding the opposition to the recent proposal to enable drug manufacturers to charge for drugs used in research studies.

  14. NASA's Plan for Improving Public Access to Federally Funded Scientific Research (Invited)

    NASA Astrophysics Data System (ADS)

    Allen, G.

    2013-12-01

    In February, 2013, OSTP issued a policy to all Federal agencies directing those that engage in $100 million or greater of federally funded research and development expenditures to develop an agency public access plan. The plan must consider both digital scientific data and scientific publications. This talk will review how NASA is currently complying with this OSTP directive, and NASA's plan for improving the public's ability to locate and access digital data and scientific publications resulting from NASA funded research. Updating NASA's policy will occur during FY 2014 and implementation of new policies and guidance will be in place by FY 2015.

  15. Stem cell research funding policies and dynamic innovation: a survey of open access and commercialization requirements.

    PubMed

    Lévesque, Maroussia; Kim, Jihyun Rosel; Isasi, Rosario; Knoppers, Bartha Maria; Plomer, Aurora; Joly, Yann

    2014-08-01

    This article compares and contrasts the pressures of both open access data sharing and commercialization policies in the context of publicly funded embryonic stem cell research (SCR). First, normative guidelines of international SCR organizations were examined. We then examined SCR funding guidelines and the project evaluation criteria of major funding organizations in the EU, the United Kingdom (UK), Spain, Canada and the United States. Our survey of policies revealed subtle pressures to commercialize research that include: increased funding availability for commercialization opportunities, assistance for obtaining intellectual property rights (IPRs) and legislation mandating commercialization. In lieu of open access models, funders are increasingly opting for limited sharing models or "protected commons" models that make the research available to researchers within the same region or those receiving the same funding. Meanwhile, there still is need for funding agencies to clarify and standardize terms such as "non-profit organizations" and "for-profit research," as more universities are pursuing for-profit or commercial opportunities.

  16. Open Access to research data - final perspectives from the RECODE project

    NASA Astrophysics Data System (ADS)

    Bigagli, Lorenzo; Sondervan, Jeroen

    2015-04-01

    Many networks, initiatives, and communities are addressing the key barriers to Open Access to data in scientific research. These organizations are typically heterogeneous and fragmented by discipline, location, sector (publishers, academics, data centers, etc.), as well as by other features. Besides, they often work in isolation, or with limited contacts with one another. The Policy RECommendations for Open Access to Research Data in Europe (RECODE) project, which will conclude in the first half of 2015, has scoped and addressed the challenges related to Open Access, dissemination and preservation of scientific data, leveraging the existing networks, initiatives, and communities. The overall objective of RECODE was to identify a series of targeted and over-arching policy recommendations for Open Access to European research data based on existing good practice. RECODE has undertaken a review of the existing state of the art and examined five case studies in different scientific disciplines: particle physics and astrophysics, clinical research, medicine and technical physiology (bioengineering), humanities (archaeology), and environmental sciences (Earth Observation). In particular for the latter discipline, GEOSS has been an optimal test bed for investigating the importance of technical and multidisciplinary interoperability, and what the challenges are in sharing and providing Open Access to research data from a variety of sources, and in a variety of formats. RECODE has identified five main technological and infrastructural challenges: • Heterogeneity - relates to interoperability, usability, accessibility, discoverability; • Sustainability - relates to obsolescence, curation, updates/upgrades, persistence, preservation; • Volume - also related to Big Data, which is somehow implied by Open Data; in our context, it relates to discoverability, accessibility (indexing), bandwidth, storage, scalability, energy footprint; • Quality - relates to completeness

  17. Stakeholder values and ecosystems in developing open access to research data.

    NASA Astrophysics Data System (ADS)

    Wessels, Bridgette; Sveinsdottir, Thordis; Smallwood, Rod

    2014-05-01

    One aspect of understanding how to develop open access to research data is to understand the values of stakeholders in the emerging open data ecosystem. The EU FP7 funded project Policy RECommendations for Open Access to Research Data in Europe (RECODE) (Grant Agreement No: 321463) undertook such research to identify stakeholder values and mapped the emerging ecosystem. In this paper we outline and discuss the findings of this research. We address three key objectives, which are: (a) the identification and mapping of the diverse range of stakeholder values in Open Access data and data dissemination and preservation; (b) mapping stakeholder values on to research ecosystems using case studies from different disciplinary perspectives; and (c) evaluate and identify good practice in addressing conflicting value chains and stakeholder fragmentation. The research was structured on three related actions: (a) an analysis of policy and related documents and protocols, in order to map the formal expression of values and motivations; (b) conducting five case studies in particle physics, health sciences, bioengineering, environmental research and archaeology. These explored issues of data size; quality control, ethics and data security; replication of large datasets; interoperability; and the preservation of diverse types of data; and (c) undertaking a validation and dissemination workshop that sought to better understand how to match policies with stakeholder drivers and motivations to increase their effectiveness in promoting Open Access to research data. The research findings include that there is clearly an overall drive for Open Data Access within the policy documents, which is part of a wider drive for open science in general. This is underpinned by the view of science as an open enterprise. Although there is a strong argument for publicly funded science to be made open to the public the details of how to make research data open as yet still unclear. Our research found

  18. GeoBrain Data Access and Analysis For Earth Science Education and Research

    NASA Astrophysics Data System (ADS)

    Deng, M.; di, L.; Luo, W.; Taber, M.; Granshaw, F.

    2008-12-01

    In the past several decades, huge amounts of Earth science data have been collected mainly through remote sensing. Those data are of great importance in Earth science education and research for human societies to better understand how the Earth is functioning as a system, to protect our home planet and to improve our life. Data access and analysis play vital roles in the multidisciplinary Earth science education and research. However, Earth science data access and analysis are always very difficult and challenging due to the complexities of the Earth science data and vast computing resources required for using those data. In order to better serve Earth science education and research needs, a NASA-funded project, named as GeoBrain, targets to facilitate Earth science data access and analysis by integrating enormous volumes of online- available satellite image data and advanced Web service technologies. The GeoBrain project develops an interoperable, three-tier, and Web-based data, information and knowledge building system. The system has implemented many cutting-edge capabilities in Earth science data discovery, visualization, access and analysis. Through its Catalogue Federation Service, GeoBrain enables the user a single point access to worldwide distributed multiple data resources. GeoBrain Data Download Web Portal with interoperable, personalized, on-demand data access and services (IPODAS), enables users to get data in the exact form (format, projection, coverage, resolution, etc.) they want. GeoBrain Online Analysis System (GeOnAS) enables the user to preprocess and do analysis of any parts of data available through GeoBrain system so that the user can get advanced information products as well as customized data products. In general, GeoBrain provides a data-rich online learning and research environment enabled by wealthy data and information available at NASA Earth Observing System (EOS) Data and Information System (EOSDIS). Students, faculty members, and

  19. NASA Plan for Increasing Access to the Results of Scientific Research

    NASA Technical Reports Server (NTRS)

    2014-01-01

    This plan is issued in response to the Executive Office of the President's February 22, 2013, Office of Science and Technology Policy (OSTP) Memorandum for the Heads of Executive Departments and Agencies, "Increasing Access to the Results of Federally Funded Scientific Research." Through this memorandum, OSTP directed all agencies with more than $100 million in annual research and development expenditures to prepare a plan for improving the public's access to the results of federally funded research. The National Aeronautics and Space Administration (NASA) invests on the order of $3 billion annually in fundamental and applied research and technology development1 across a broad range of topics, including space and Earth sciences, life and physical sciences, human health, aeronautics, and technology. Promoting the full and open sharing of data with research communities, private industry, academia, and the general public is one of NASA's longstanding core values. For example, NASA's space and suborbital mission personnel routinely process, archive, and distribute their data to researchers around the globe. This plan expands the breadth of NASA's open-access culture to include data and publications for all of the scientific research that the Agency sponsors.

  20. MaizeGDB: Global support for maize research through open access information [abstract

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MaizeGDB is the open-access global repository for maize genetic and genomic information – from single genes that determine nutritional quality to whole genome-scale data for complex traits including yield and drought tolerance. The data and tools at MaizeGDB enable researchers from Ethiopia to Ghan...

  1. Opening of Dead Sea Scrolls Archive Underlines Problems That Can Complicate Access to Research Materials.

    ERIC Educational Resources Information Center

    Coughlin, Ellen K.

    1991-01-01

    The Huntington Library (California) decision to make generally accessible, for the first time, copies of photographs of the Dead Sea Scrolls, previously tightly controlled by a small group of editors, is hailed as breaking a scholarly monopoly over an important intellectual resource, reaffirming the mission of the research library and the…

  2. 45 CFR 601.9 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Access by historical researchers and former Presidential appointees. 601.9 Section 601.9 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CLASSIFICATION AND DECLASSIFICATION OF NATIONAL SECURITY INFORMATION §...

  3. On Open Access to Research: The Green, the Gold, and the Public Good

    ERIC Educational Resources Information Center

    Roach, Audra K.; Gainer, Jesse

    2013-01-01

    In this column the authors discuss barriers to worldwide open access to peer-reviewed journal articles online and how they might be addressed by literacy scholars. They highlight economic and ethical problems associated with the current subscription-based system for distributing articles (which sometimes works against the ideals of research and…

  4. 32 CFR 2400.26 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Access by historical researchers and former Presidential appointees. 2400.26 Section 2400.26 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION...

  5. Opening a Gateway to College Access: Algebra at the Right Time. Research Brief

    ERIC Educational Resources Information Center

    Snipes, Jason; Finkelstein, Neal

    2015-01-01

    Four years of math in high school, with a strong foundation in algebra that builds from middle school, is key to higher education access. Therefore, ensuring that middle and high school students succeed in math--and in algebra in particular--is an important issue for policy and practice. This research brief examines three recent Regional…

  6. Open-Access Metabolomics Databases for Natural Product Research: Present Capabilities and Future Potential

    PubMed Central

    Johnson, Sean R.; Lange, Bernd Markus

    2015-01-01

    Various databases have been developed to aid in assigning structures to spectral peaks observed in metabolomics experiments. In this review article, we discuss the utility of currently available open-access spectral and chemical databases for natural products discovery. We also provide recommendations on how the research community can contribute to further improvements. PMID:25789275

  7. Improving Access to Needed Health Care Improves Low-Income Children's Quality of Life: Research Highlights

    ERIC Educational Resources Information Center

    Seid, Michael. Varni, James W.; Cummings, Leslie; Schonlau, Matthias

    2006-01-01

    This research brief describes an examination of the effect of the State Children's Health Insurance Program (SCHIP) on children's access to needed health services and on their quality of life. The analysis focused on a sample of California families who had recently enrolled in that state's SCHIP. The study found that, after enrollment, children…

  8. Open-access metabolomics databases for natural product research: present capabilities and future potential.

    PubMed

    Johnson, Sean R; Lange, Bernd Markus

    2015-01-01

    Various databases have been developed to aid in assigning structures to spectral peaks observed in metabolomics experiments. In this review article, we discuss the utility of currently available open-access spectral and chemical databases for natural products discovery. We also provide recommendations on how the research community can contribute to further improvements.

  9. Topographic Maps: Rediscovering an Accessible Data Source for Land Cover Change Research

    ERIC Educational Resources Information Center

    McChesney, Ron; McSweeney, Kendra

    2005-01-01

    Given some limitations of satellite imagery for the study of land cover change, we draw attention here to a robust and often overlooked data source for use in student research: USGS topographic maps. Topographic maps offer an inexpensive, rapid, and accessible means for students to analyze land cover change over large areas. We demonstrate our…

  10. Acquiring Research Access: Perspectives from Gatekeepers and Parents of Children with Anorexia Nervosa

    ERIC Educational Resources Information Center

    Hunt, Tamara Jo-Lynne

    2010-01-01

    The purpose of this study was to understand the conditions necessary to gain research access to parents of children with anorexia. In this study, I also examined and explored avenues parents have for sharing their story and their experiences of parenting a child with anorexia as well as whether gatekeepers have a role in connecting parents and…

  11. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one...

  12. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC ethical requirements. 120.851... Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and their... § 120.140. In addition, they are subject to the following: (a) Any benefit flowing to a CDC's...

  13. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except...

  14. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one...

  15. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members,...

  16. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except...

  17. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except...

  18. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members,...

  19. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except...

  20. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one...

  1. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one...

  2. 13 CFR 120.830 - Reports a CDC must submit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Reports a CDC must submit. 120.830... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.830 Reports a CDC must submit. A CDC must submit the following reports to SBA: (a) An annual report within one...

  3. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members,...

  4. 13 CFR 120.821 - CDC Area of Operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC Area of Operations. 120.821... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.821 CDC Area of Operations. A CDC must operate only within its designated Area of Operations approved by SBA except...

  5. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members,...

  6. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC ethical requirements. 120.851... Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and their... § 120.140. In addition, they are subject to the following: (a) Any benefit flowing to a CDC's...

  7. 13 CFR 120.823 - CDC Board of Directors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC Board of Directors. 120.823... Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.823 CDC Board of Directors. The CDC must have a Board of Directors chosen from the membership by the members,...

  8. International Policies on Sharing Genomic Research Results with Relatives: Approaches to Balancing Privacy with Access.

    PubMed

    Branum, Rebecca; Wolf, Susan M

    2015-01-01

    Returning genetic research results to relatives raises complex issues. In order to inform the U.S. debate, this paper analyzes international law and policies governing the sharing of genetic research results with relatives and identifies key themes and lessons. The laws and policies from other countries demonstrate a range of approaches to balancing individual privacy and autonomy with family access for health benefit, offering important lessons for further development of approaches in the United States.

  9. Fast Action Can Prevent Sepsis Death: CDC

    MedlinePlus

    ... fullstory_160574.html Fast Action Can Prevent Sepsis Death: CDC Know the signs of extreme response to ... treated long before it causes severe illness or death, U.S. health officials report. Sepsis, or septicemia, occurs ...

  10. CDC's Response to Zika: Enjoy Your Vacation

    MedlinePlus

    ... travel notices: cdc. gov/ travel Pack to prevent • Insect repellent (Look for these ingredients: DEET, picaridin, IR3535, OLE, ... if you might have sex) Protect yourself • Use insect repellent. Reapply as directed. Remember to apply sunscreen first ...

  11. Cancer Experts Endorse CDC's HPV Vaccine Guidelines

    MedlinePlus

    ... html Cancer Experts Endorse CDC's HPV Vaccine Guidelines Boys and girls should start the shots at age 11 or ... on HPV vaccination: HPV vaccination should begin for girls and boys at 11 or 12 years, but children as ...

  12. CDC Updates Spending Plans to Combat Zika

    MedlinePlus

    ... and response efforts, agency Chief Operating Officer Sherri Berger said Tuesday. The agency also plans to provide $ ... use in detecting and tracking the Zika virus, Berger added. In addition, the CDC will provide $10 ...

  13. Zika Spreading Rapidly Through Puerto Rico: CDC

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_159430.html Zika Spreading Rapidly Through Puerto Rico: CDC Possibly hundreds ... 2016 FRIDAY, June 17, 2016 (HealthDay News) -- The Zika virus is spreading fast through Puerto Rico, placing ...

  14. Tighten Teens' Nighttime Driving Restrictions: CDC

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_160130.html Tighten Teens' Nighttime Driving Restrictions: CDC Midnight cutoff is too ... THURSDAY, July 28, 2016 (HealthDay News) -- Getting U.S. teens out of the driver's seat before midnight would ...

  15. CDC Updates Zika Guidelines for Pregnant Women

    MedlinePlus

    ... medlineplus.gov/news/fullstory_160052.html CDC Updates Zika Guidelines for Pregnant Women Any sex partner, male ... News) -- U.S. health officials on Monday updated their Zika virus guidelines, saying that pregnant women could contract ...

  16. CDC Study Finds Fecal Contamination in Pools

    MedlinePlus

    ... Communication (404) 639-3286 CDC study finds fecal contamination in pools A study of public pools done ... The E. coli is a marker for fecal contamination. Finding a high percentage of E. coli-positive ...

  17. Linking research to global health equity: the contribution of product development partnerships to access to medicines and research capacity building.

    PubMed

    Pratt, Bridget; Loff, Bebe

    2013-11-01

    Certain product development partnerships (PDPs) recognize that to promote the reduction of global health disparities they must create access to their products and strengthen research capacity in developing countries. We evaluated the contribution of 3 PDPs--Medicines for Malaria Venture, Drugs for Neglected Diseases Initiative, and Institute for One World Health--according to Frost and Reich's access framework. We also evaluated PDPs' capacity building in low- and middle-income countries at the individual, institutional, and system levels. We found that these PDPs advance public health by ensuring their products' registration, distribution, and adoption into national treatment policies in disease-endemic countries. Nonetheless, ensuring broad, equitable access for these populations--high distribution coverage; affordability, particularly for the poor; and adoption at provider and end-user levels--remains a challenge.

  18. Linking Research to Global Health Equity: The Contribution of Product Development Partnerships to Access to Medicines and Research Capacity Building

    PubMed Central

    Loff, Bebe

    2013-01-01

    Certain product development partnerships (PDPs) recognize that to promote the reduction of global health disparities they must create access to their products and strengthen research capacity in developing countries. We evaluated the contribution of 3 PDPs—Medicines for Malaria Venture, Drugs for Neglected Diseases Initiative, and Institute for One World Health—according to Frost and Reich’s access framework. We also evaluated PDPs’ capacity building in low- and middle-income countries at the individual, institutional, and system levels. We found that these PDPs advance public health by ensuring their products’ registration, distribution, and adoption into national treatment policies in disease-endemic countries. Nonetheless, ensuring broad, equitable access for these populations—high distribution coverage; affordability, particularly for the poor; and adoption at provider and end-user levels—remains a challenge. PMID:24028246

  19. The ethics of attaching research conditions to access to new health technologies.

    PubMed

    Holland, Stephen; Hope, Tony

    2012-06-01

    Decisions on which new health technologies to provide are controversial because of the scarcity of healthcare resources, the competing demands of payers, providers and patients and the uncertainty of the evidence base. Given this, additional information about new health technologies is often considered valuable. One response is to make access to a new health technology conditional on further research. Access can be restricted to patients who participate in a research study, such as a randomised controlled trial; alternatively, a new treatment can be made generally available, but only on condition that further evidence is collected (eg, on long-term outcomes and adverse events, in patient registries). The National Institute for Health and Clinical Excellence (NICE), which provides guidance on which new health technologies to make available under the UK's NHS, for example, has made some research conditional recommendations, and the current interest in such options suggests that they are likely to become more prevalent in the future. This paper identifies and discusses the main ethical issues created by this distinctive range of recommendations. We argue that decisions to put research conditions on access to new technologies are compatible with widely accepted values, principles and practices relevant to resource allocation. However, there are important features of these distinctive judgements that must be taken into account by resource allocation decision-making bodies and research ethics committees, and that require new sorts of empirical data.

  20. Perspectives in understanding open access to research data - infrastructure and technology challenges

    NASA Astrophysics Data System (ADS)

    Bigagli, Lorenzo; Sondervan, Jeroen

    2014-05-01

    The Policy RECommendations for Open Access to Research Data in Europe (RECODE) project, started in February 2013 with a duration of two years, has the objective to identify a series of targeted and over-arching policy recommendations for Open Access to European research data, based on existing good practice and addressing such hindering factors as stakeholder fragmentation, technical and infrastructural issues, ethical and legal issues, and financial and institutional policies. In this work we focus on the technical and infrastructural aspect, where by "infrastructure" we mean the technological assets (hardware and software), the human resources, and all the policies, processes, procedures and training for managing and supporting its continuous operation and evolution. The context targeted by RECODE includes heterogeneous networks, initiatives, projects and communities that are fragmented by discipline, geography, stakeholder category (publishers, academics, repositories, etc.) as well as other boundaries. Many of these organizations are already addressing key technical and infrastructural barriers to Open Access to research data. Such barriers may include: lack of automatic mechanisms for policy enforcement, lack of metadata and data models supporting open access, obsolescence of infrastructures, scarce awareness about new technological solutions, lack of training and/or expertise on IT and semantics aspects. However, these organizations are often heterogeneous and fragmented by discipline, geography, stakeholder category (publishers, academics, repositories, etc.) as well as other boundaries, and often work in isolation, or with limited contact with one another. RECODE has addressed these challenges, and the possible solutions to mitigate them, engaging all the identified stakeholders in a number of ways, including an online questionnaire, case studies interviews, literature review, a workshop. The conclusions have been validated by the RECODE Advisory Board and

  1. Tools for Integrating Data Access from the IRIS DMC into Research Workflows

    NASA Astrophysics Data System (ADS)

    Reyes, C. G.; Suleiman, Y. Y.; Trabant, C.; Karstens, R.; Weertman, B. R.

    2012-12-01

    Web service interfaces at the IRIS Data Management Center (DMC) provide access to a vast archive of seismological and related geophysical data. These interfaces are designed to easily incorporate data access into data processing workflows. Examples of data that may be accessed include: time series data, related metadata, and earthquake information. The DMC has developed command line scripts, MATLAB® interfaces and a Java library to support a wide variety of data access needs. Users of these interfaces do not need to concern themselves with web service details, networking, or even (in most cases) data conversion. Fetch scripts allow access to the DMC archive and are a comfortable fit for command line users. These scripts are written in Perl and are well suited for automation and integration into existing workflows on most operating systems. For metdata and event information, the Fetch scripts even parse the returned data into simple text summaries. The IRIS Java Web Services Library (IRIS-WS Library) allows Java developers the ability to create programs that access the DMC archives seamlessly. By returning the data and information as native Java objects the Library insulates the developer from data formats, network programming and web service details. The MATLAB interfaces leverage this library to allow users access to the DMC archive directly from within MATLAB (r2009b or newer), returning data into variables for immediate use. Data users and research groups are developing other toolkits that use the DMC's web services. Notably, the ObsPy framework developed at LMU Munich is a Python Toolbox that allows seamless access to data and information via the DMC services. Another example is the MATLAB-based GISMO and Waveform Suite developments that can now access data via web services. In summary, there now exist a host of ways that researchers can bring IRIS DMC data directly into their workflows. MATLAB users can use irisFetch.m, command line users can use the various

  2. Modulation of yeast telomerase activity by Cdc13 and Est1 in vitro

    PubMed Central

    Chen, Yu-Fan; Lu, Chia-Ying; Lin, Yi-Chien; Yu, Tai-Yuan; Chang, Chun-Ping; Li, Jing-Ru; Li, Hung-Wen; Lin, Jing-Jer

    2016-01-01

    Telomerase is the enzyme involved in extending telomeric DNA. Control of telomerase activity by modulating its access to chromosome ends is one of the most important fundamental mechanisms. This study established an in vitro yeast telomerase reconstitution system that resembles telomere replication in vivo. In this system, a tailed-duplex DNA formed by telomeric DNA was employed to mimic the structure of telomeres. The core catalytic components of telomerase Est2/Tlc1 RNA were used as the telomeric DNA extension machinery. Using the reconstituted systems, this study found that binding of Cdc13 to telomeric DNA inhibited the access of telomerase to its substrate. The result was further confirmed by a single-molecule approach using the tethered-particle motion (TPM)-based telomerase assay. The findings also showed that the inhibitory effect can be relieved by telomerase-associated protein Est1, consistent with the role of Cdc13 and Est1 in regulating telomere extension in vivo. Significantly, this study found that the DNA binding property of Cdc13 was altered by Est1, providing the first mechanistic evidence of Est1 regulating the access of telomerase to its substrate. Thus, the roles of Cdc13 and Est1 in modulating telomerase activity were clearly defined using the in vitro reconstituted system. PMID:27659693

  3. Enabling cross-disciplinary research by linking data to Open Access publications

    NASA Astrophysics Data System (ADS)

    Rettberg, N.

    2012-04-01

    OpenAIREplus focuses on the linking of research data to associated publications. The interlinking of research objects has implications for optimising the research process, allowing the sharing, enrichment and reuse of data, and ultimately serving to make open data an essential part of first class research. The growing call for more concrete data management and sharing plans, apparent at funder and national level, is complemented by the increasing support for a scientific infrastructure that supports the seamless access to a range of research materials. This paper will describe the recently launched OpenAIREplus and will detail how it plans to achieve its goals of developing an Open Access participatory infrastructure for scientific information. OpenAIREplus extends the current collaborative OpenAIRE project, which provides European researchers with a service network for the deposit of peer-reviewed FP7 grant-funded Open Access publications. This new project will focus on opening up the infrastructure to data sources from subject-specific communities to provide metadata about research data and publications, facilitating the linking between these objects. The ability to link within a publication out to a citable database, or other research data material, is fairly innovative and this project will enable users to search, browse, view, and create relationships between different information objects. In this regard, OpenAIREplus will build on prototypes of so-called "Enhanced Publications", originally conceived in the DRIVER-II project. OpenAIREplus recognizes the importance of representing the context of publications and datasets, thus linking to resources about the authors, their affiliation, location, project data and funding. The project will explore how links between text-based publications and research data are managed in different scientific fields. This complements a previous study in OpenAIRE on current disciplinary practices and future needs for infrastructural

  4. 22 CFR 9.12 - Access to classified information by historical researchers and certain former government personnel.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Access to classified information by historical... GENERAL SECURITY INFORMATION REGULATIONS § 9.12 Access to classified information by historical researchers... information by historical researchers and certain former government personnel, see Sec. 171.24 of this Title....

  5. Research on Rural Residence and Access to Drug Abuse Services: Where Are We and where Do We Go?

    ERIC Educational Resources Information Center

    Borders, Tyrone F.; Booth, Brenda M.

    2007-01-01

    Context: Illicit drug use is common in rural areas, but very little research has investigated rural populations' access to drug abuse services. Purpose: To describe the current state of the scientific literature on access to drug abuse services in rural areas and suggest directions for future research. Methods: We performed a literature review of…

  6. CDC42 Use in Viral Cell Entry Processes by RNA Viruses

    PubMed Central

    Swaine, Thomas; Dittmar, Matthias T.

    2015-01-01

    The cellular actin cytoskeleton presents a barrier that must be overcome by many viruses, and it has become increasingly apparent many viral species have developed a diverse repertoire of mechanisms to hijack cellular actin-regulating signalling pathways as part of their cell entry processes. The Rho family GTPase Cdc42 is appreciated as a key moderator of cellular actin dynamics, and the development of specific Cdc42-inhibiting agents has given us an unprecedented ability to investigate its individual role in signalling pathways. However, investigative use of said agents, and the subsequent characterisation of the role Cdc42 plays in viral entry processes has been lacking. Here, we describe the current literature on the role of Cdc42 in human immunodeficiency virus (HIV)-1 cell entry, which represents the most investigated instance of Cdc42 function in viral cell entry processes, and also review evidence of Cdc42 use in other RNA virus cell entries, demonstrating prime areas for more extensive research using similar techniques. PMID:26690467

  7. The NCAR Research Data Archive's Hybrid Approach for Data Discovery and Access

    NASA Astrophysics Data System (ADS)

    Schuster, D.; Worley, S. J.

    2013-12-01

    The NCAR Research Data Archive (RDA http://rda.ucar.edu) maintains a variety of data discovery and access capabilities for it's 600+ dataset collections to support the varying needs of a diverse user community. In-house developed and standards-based community tools offer services to more than 10,000 users annually. By number of users the largest group is external and access the RDA through web based protocols; the internal NCAR HPC users are fewer in number, but typically access more data volume. This paper will detail the data discovery and access services maintained by the RDA to support both user groups, and show metrics that illustrate how the community is using the services. The distributed search capability enabled by standards-based community tools, such as Geoportal and an OAI-PMH access point that serves multiple metadata standards, provide pathways for external users to initially discover RDA holdings. From here, in-house developed web interfaces leverage primary discovery level metadata databases that support keyword and faceted searches. Internal NCAR HPC users, or those familiar with the RDA, may go directly to the dataset collection of interest and refine their search based on rich file collection metadata. Multiple levels of metadata have proven to be invaluable for discovery within terabyte-sized archives composed of many atmospheric or oceanic levels, hundreds of parameters, and often numerous grid and time resolutions. Once users find the data they want, their access needs may vary as well. A THREDDS data server running on targeted dataset collections enables remote file access through OPENDAP and other web based protocols primarily for external users. In-house developed tools give all users the capability to submit data subset extraction and format conversion requests through scalable, HPC based delayed mode batch processing. Users can monitor their RDA-based data processing progress and receive instructions on how to access the data when it is

  8. Structure of human Cdc45 and implications for CMG helicase function

    PubMed Central

    Simon, Aline C.; Sannino, Vincenzo; Costanzo, Vincenzo; Pellegrini, Luca

    2016-01-01

    Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. Here we report the 2.1-Å crystal structure of human Cdc45, which confirms its evolutionary link with the bacterial RecJ nuclease and reveals several unexpected features that underpin its function in eukaryotic DNA replication. These include a long-range interaction between N- and C-terminal DHH domains, blocking access to the DNA-binding groove of its RecJ-like fold, and a helical insertion in its N-terminal DHH domain, which appears poised for replisome interactions. In combination with available electron microscopy data, we validate by mutational analysis the mechanism of Cdc45 association with the MCM ring and GINS co-activator, critical for CMG assembly. These findings provide an indispensable molecular basis to rationalize the essential role of Cdc45 in genomic duplication. PMID:27189187

  9. The potential exploitation of research participants in high income countries who lack access to health care.

    PubMed

    Dal-Ré, Rafael; Rid, Annette; Emanuel, Ezekiel; Wendler, David

    2016-05-01

    There are millions of individuals living in North America and the European Union who lack access to healthcare services. When these individuals participate in research, they are at increased risk of being exposed to the risks and burdens of clinical trials without realizing the benefits that result from them. The mechanisms that have been proposed to ensure that research participants in low- and middle-income countries are not exploited are unlikely to protect participants in high-income countries. The present manuscript argues that one way to address concerns about exploitation in high-income countries would be to require sponsors to provide targeted benefits such as medical treatment during the trial, or the study drug after the trial. The latter could be achieved through extension studies, expanded access programs, or named-patient programs. Sponsors also might provide non-medical benefits, such as education or social support. Ethical and regulatory guidance should be revised to ensure that research participants in high-income countries who lack access to healthcare services receive sufficient benefits.

  10. Patients, privacy and trust: patients' willingness to allow researchers to access their medical records.

    PubMed

    Damschroder, Laura J; Pritts, Joy L; Neblo, Michael A; Kalarickal, Rosemarie J; Creswell, John W; Hayward, Rodney A

    2007-01-01

    The federal Privacy Rule, implemented in the United States in 2003, as part of the Health Insurance Portability and Accountability Act of 1996 (HIPAA), created new restrictions on the release of medical information for research. Many believe that its restrictions have fallen disproportionately on researchers prompting some to call for changes to the Rule. Here we ask what patients think about researchers' access to medical records, and what influences these opinions. A sample of 217 patients from 4 Veteran Affairs (VA) facilities deliberated in small groups at each location with the opportunity to question experts and inform themselves about privacy issues related to medical records research. After extensive deliberation, these patients were united in their inclination to share their medical records for research. Yet they were also united in their recommendations to institute procedures that would give them more control over whether and how their medical records are used for research. We integrated qualitative and quantitative results to derive a better understanding of this apparent paradox. Our findings can best be presented as answers to questions related to five dimensions of trust: Patients' trust in VA researchers was the most powerful determinant of the kind of control they want over their medical records. More specifically, those who had lower trust in VA researchers were more likely to recommend a more stringent process for obtaining individual consent. Insights on the critical role of trust suggest actions that researchers and others can take to more fully engage patients in research.

  11. Contextual Uncertainties, Human Mobility, and Perceived Food Environment: The Uncertain Geographic Context Problem in Food Access Research.

    PubMed

    Chen, Xiang; Kwan, Mei-Po

    2015-09-01

    We examined the uncertainty of the contextual influences on food access through an analytic framework of the uncertain geographic context problem (UGCoP). We first examined the compounding effects of two kinds of spatiotemporal uncertainties on people's everyday efforts to procure food and then outlined three key dimensions (food access in real time, temporality of the food environment, and perceived nutrition environment) in which research on food access must improve to better represent the contributing environmental influences that operate at the individual level. Guidelines to address the UGCoP in future food access research are provided to account for the multidimensional influences of the food environment on dietary behaviors.

  12. Patients' Online Access to Their Primary Care Electronic Health Records and Linked Online Services: Implications for Research and Practice.

    PubMed

    Mold, Freda; de Lusignan, Simon

    2015-12-04

    Online access to medical records and linked services, including requesting repeat prescriptions and booking appointments, enables patients to personalize their access to care. However, online access creates opportunities and challenges for both health professionals and their patients, in practices and in research. The challenges for practice are the impact of online services on workload and the quality and safety of health care. Health professionals are concerned about the impact on workload, especially from email or other online enquiry systems, as well as risks to privacy. Patients report how online access provides a convenient means through which to access their health provider and may offer greater satisfaction if they get a timely response from a clinician. Online access and services may also result in unforeseen consequences and may change the nature of the patient-clinician interaction. Research challenges include: (1) Ensuring privacy, including how to control inappropriate carer and guardian access to medical records; (2) Whether online access to records improves patient safety and health outcomes; (3) Whether record access increases disparities across social classes and between genders; and (4) Improving efficiency. The challenges for practice are: (1) How to incorporate online access into clinical workflow; (2) The need for a business model to fund the additional time taken. Creating a sustainable business model for a safe, private, informative, more equitable online service is needed if online access to records is to be provided outside of pay-for-service systems.

  13. High throughput tools to access images from clinical archives for research.

    PubMed

    Murphy, Shawn N; Herrick, Christopher; Wang, Yanbing; Wang, Taowei David; Sack, Darren; Andriole, Katherine P; Wei, Jesse; Reynolds, Nathaniel; Plesniak, Wendy; Rosen, Bruce R; Pieper, Steven; Gollub, Randy L

    2015-04-01

    Historically, medical images collected in the course of clinical care have been difficult to access for secondary research studies. While there is a tremendous potential value in the large volume of studies contained in clinical image archives, Picture Archiving and Communication Systems (PACS) are designed to optimize clinical operations and workflow. Search capabilities in PACS are basic, limiting their use for population studies, and duplication of archives for research is costly. To address this need, we augment the Informatics for Integrating Biology and the Bedside (i2b2) open source software, providing investigators with the tools necessary to query and integrate medical record and clinical research data. Over 100 healthcare institutions have installed this suite of software tools that allows investigators to search medical record metadata including images for specific types of patients. In this report, we describe a new Medical Imaging Informatics Bench to Bedside (mi2b2) module ( www.mi2b2.org ), available now as an open source addition to the i2b2 software platform that allows medical imaging examinations collected during routine clinical care to be made available to translational investigators directly from their institution's clinical PACS for research and educational use in compliance with the Health Insurance Portability and Accountability Act (HIPAA) Omnibus Rule. Access governance within the mi2b2 module is customizable per institution and PACS minimizing impact on clinical systems. Currently in active use at our institutions, this new technology has already been used to facilitate access to thousands of clinical MRI brain studies representing specific patient phenotypes for use in research. PMID:25316195

  14. Establishment of a cell model for screening antibody drugs against rheumatoid arthritis with ADCC and CDC.

    PubMed

    Yan, Li; Hu, Rui; Tu, Song; Cheng, Wen-Jun; Zheng, Qiong; Wang, Jun-Wen; Kan, Wu-Sheng; Ren, Yi-Jun

    2015-01-01

    TNFα played a dominant role in the development and progression of rheumatoid arthritis (RA). Clinical trials proved the efficacies of anti-TNFα agents for curing RA. However, most researchers were concentrating on their abilities of neutralizing TNFα, the potencies of different anti-TNFα agents varied a lot due to the antibody-dependent cell-mediated cytotoxicity (ADCC) or complement dependent cytotoxicity (CDC). For better understanding and differentiating the potentiality of various candidate anti-TNF reagents at the stage of new drug research and development, present study established a cell model expressing the transmembrane TNFα for usage in in vitro ADCC or CDC assay, meanwhile, the assay protocol described here could provide guidelines for screening macromolecular antibody drugs. A stable cell subline bearing transmembrane TNFα was first established by conventional transfection method, the expression of transmembrane TNFα was approved by flow cytometer, and the performance of the stable subline in ADCC and CDC assay was evaluated, using human peripheral blood mononuclear cells as effector cells, and Adalimumab as the anti-TNFα reagent. The stable cell subline demonstrated high level of surface expression of transmembrane TNFα, and Adalimumab exerted both ADCC and CDC effects on this cell model. In conclusion, the stable cell line we established in present research could be used in ADCC or CDC assay for screening antibody drugs, which would provide in-depth understanding of the potencies of candidate antibody drugs in addition to the traditional TNFα neutralizing assay.

  15. Establishment of a cell model for screening antibody drugs against rheumatoid arthritis with ADCC and CDC.

    PubMed

    Yan, Li; Hu, Rui; Tu, Song; Cheng, Wen-Jun; Zheng, Qiong; Wang, Jun-Wen; Kan, Wu-Sheng; Ren, Yi-Jun

    2015-01-01

    TNFα played a dominant role in the development and progression of rheumatoid arthritis (RA). Clinical trials proved the efficacies of anti-TNFα agents for curing RA. However, most researchers were concentrating on their abilities of neutralizing TNFα, the potencies of different anti-TNFα agents varied a lot due to the antibody-dependent cell-mediated cytotoxicity (ADCC) or complement dependent cytotoxicity (CDC). For better understanding and differentiating the potentiality of various candidate anti-TNF reagents at the stage of new drug research and development, present study established a cell model expressing the transmembrane TNFα for usage in in vitro ADCC or CDC assay, meanwhile, the assay protocol described here could provide guidelines for screening macromolecular antibody drugs. A stable cell subline bearing transmembrane TNFα was first established by conventional transfection method, the expression of transmembrane TNFα was approved by flow cytometer, and the performance of the stable subline in ADCC and CDC assay was evaluated, using human peripheral blood mononuclear cells as effector cells, and Adalimumab as the anti-TNFα reagent. The stable cell subline demonstrated high level of surface expression of transmembrane TNFα, and Adalimumab exerted both ADCC and CDC effects on this cell model. In conclusion, the stable cell line we established in present research could be used in ADCC or CDC assay for screening antibody drugs, which would provide in-depth understanding of the potencies of candidate antibody drugs in addition to the traditional TNFα neutralizing assay. PMID:26884918

  16. Corynebacterium CDC Group G Native and Prosthetic Valve Endocarditis.

    PubMed

    Sattar, Adil; Yu, Siegfried; Koirala, Janak

    2015-08-11

    We report the first case of native and recurrent prosthetic valve endocarditis with Corynebacterium CDC group G, a rarely reported cause of infective endocarditis (IE). Previously, there have been only two cases reported for prosthetic valve IE caused by these organisms. A 69-year-old female with a known history of mitral valve regurgitation presented with a 3-day history of high-grade fever, pleuritic chest pain and cough. Echocardiography confirmed findings of mitral valve thickening consistent with endocarditis, which subsequently progressed to become large and mobile vegetations. Both sets of blood cultures taken on admission were positive for Corynebacterium CDC group G. Despite removal of a long-term venous access port, the patient's presumed source of line associated bacteremia, mitral valve replacement, and aggressive antibiotic therapy, the patient had recurrence of vegetations on the prosthetic valve. She underwent replacement of her prosthetic mitral valve in the subsequent 2 weeks, before she progressed to disseminated intravascular coagulation and expired. Although they are typically considered contaminants, corynebacteria, in the appropriate clinical setting, should be recognized, identified, and treated as potentially life-threatening infections, particularly in the case of line-associated bacteremias, and native and prosthetic valve endocarditis.

  17. Corynebacterium CDC Group G Native and Prosthetic Valve Endocarditis

    PubMed Central

    Sattar, Adil; Yu, Siegfried; Koirala, Janak

    2015-01-01

    We report the first case of native and recurrent prosthetic valve endocarditis with Corynebacterium CDC group G, a rarely reported cause of infective endocarditis (IE). Previously, there have been only two cases reported for prosthetic valve IE caused by these organisms. A 69-year-old female with a known history of mitral valve regurgitation presented with a 3-day history of high-grade fever, pleuritic chest pain and cough. Echocardiography confirmed findings of mitral valve thickening consistent with endocarditis, which subsequently progressed to become large and mobile vegetations. Both sets of blood cultures taken on admission were positive for Corynebacterium CDC group G. Despite removal of a long-term venous access port, the patient’s presumed source of line associated bacteremia, mitral valve replacement, and aggressive antibiotic therapy, the patient had recurrence of vegetations on the prosthetic valve. She underwent replacement of her prosthetic mitral valve in the subsequent 2 weeks, before she progressed to disseminated intravascular coagulation and expired. Although they are typically considered contaminants, corynebacteria, in the appropriate clinical setting, should be recognized, identified, and treated as potentially life-threatening infections, particularly in the case of line-associated bacteremias, and native and prosthetic valve endocarditis. PMID:26500737

  18. Politics and the Dilemma of Meaningful Access to Education: The Nigerian Story. CREATE Pathways to Access. Research Monograph No. 56

    ERIC Educational Resources Information Center

    Obanya, Pai

    2011-01-01

    This paper makes a case for "good politics for good education", with special reference to Nigeria. It surveys the impact of good and bad politics on the attainment of Meaningful Access to education with special focus on Nigeria's Universal Basic Education (UBE) programme. Good politics is to be likened to what the French call "la politique au…

  19. Access to Elementary Education in India: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 44

    ERIC Educational Resources Information Center

    Little, Angela W.

    2010-01-01

    This monograph examines progress in, and policies for, access to elementary education over the past 60 years, the role played by political factors in the process of policy formulation and implementation and the drivers and inhibitors of the implementation of reforms in elementary education in recent years in India. Drawing on interviews and…

  20. Fosterage and Access to Schooling in Savelugu-Nanton, Ghana. CREATE Pathways to Access. Research Monograph No. 59

    ERIC Educational Resources Information Center

    Rolleston, Caine

    2011-01-01

    Fosterage is an important cultural institution which serves to strengthen kinship solidarity among a range of other functions including meeting needs for child labour. Its effects on education are ambiguous. This study examines fostering as a possible contributor to the low levels of educational access and progress in the district using secondary…

  1. Universal Access to Health and Universal Health Coverage: identification of nursing research priorities in Latin America

    PubMed Central

    Cassiani, Silvia Helena De Bortoli; Bassalobre-Garcia, Alessandra; Reveiz, Ludovic

    2015-01-01

    Objective: To estabilish a regional list for nursing research priorities in health systems and services in the Region of the Americas based on the concepts of Universal Access to Health and Universal Health Coverage. Method: five-stage consensus process: systematic review of literature; appraisal of resulting questions and topics; ranking of the items by graduate program coordinators; discussion and ranking amongst a forum of researchers and public health leaders; and consultation with the Ministries of Health of the Pan American Health Organization's member states. Results: the resulting list of nursing research priorities consists of 276 study questions/ topics, which are sorted into 14 subcategories distributed into six major categories: 1. Policies and education of nursing human resources; 2. Structure, organization and dynamics of health systems and services; 3. Science, technology, innovation, and information systems in public health; 4. Financing of health systems and services; 5. Health policies, governance, and social control; and 6. Social studies in the health field. Conclusion: the list of nursing research priorities is expected to serve as guidance and support for nursing research on health systems and services across Latin America. Not only researchers, but also Ministries of Health, leaders in public health, and research funding agencies are encouraged to use the results of this list to help inform research-funding decisions. PMID:26487014

  2. Girls' Access to Education in China: Actors, Cultures and the Windmill of Development Management. CREATE Pathways to Access. Research Monograph No. 39

    ERIC Educational Resources Information Center

    Wang, Xiaojun Grace

    2010-01-01

    The world has a mixed record towards achieving EFA [Education for All] and the MDGs [Millennium Development Goals] in relation to the targets on gender equity in basic education. For researchers and practitioners, this raises the question of which factors influence the processes leading to the improvement of access and quality of girls' education…

  3. Increasing Need-Based Grant Aid Is the Most Efficient Way To Expand College Access. Illuminations: Highlighting Important Research in Postsecondary Education Access. New Agenda Series.

    ERIC Educational Resources Information Center

    Lumina Foundation for Education, 2004

    2004-01-01

    This two-page summary offers an overview of a "New Agenda Series" publication relating to need-based grant aid. The federal and state governments share the responsibility for providing access to postsecondary education. They do this through direct appropriations, student financial aid programs and other support for research and educational…

  4. CDC 2011 Estimates of Foodborne Illness in the United States

    MedlinePlus

    ... Total number of foodborne illnesses each year CDC estimated the number of illnesses, hospitalizations, and deaths caused by both known and unspecified agents. CDC estimated what proportion of each were foodborne. The first ...

  5. SensorWeb Hub infrastructure for open access to scientific research data

    NASA Astrophysics Data System (ADS)

    de Filippis, Tiziana; Rocchi, Leandro; Rapisardi, Elena

    2015-04-01

    The sharing of research data is a new challenge for the scientific community that may benefit from a large amount of information to solve environmental issues and sustainability in agriculture and urban contexts. Prerequisites for this challenge is the development of an infrastructure that ensure access, management and preservation of data, technical support for a coordinated and harmonious management of data that, in the framework of Open Data Policies, should encourages the reuse and the collaboration. The neogeography and the citizen as sensors approach, highlight that new data sources need a new set of tools and practices so to collect, validate, categorize, and use / access these "crowdsourced" data, that integrate the data sets produced in the scientific field, thus "feeding" the overall available data for analysis and research. When the scientific community embraces the dimension of collaboration and sharing, access and re-use, in order to accept the open innovation approach, it should redesign and reshape the processes of data management: the challenges of technological and cultural innovation, enabled by web 2.0 technologies, bring to the scenario where the sharing of structured and interoperable data will constitute the unavoidable building block to set up a new paradigm of scientific research. In this perspective the Institute of Biometeorology, CNR, whose aim is contributing to sharing and development of research data, has developed the "SensorWebHub" (SWH) infrastructure to support the scientific activities carried out in several research projects at national and international level. It is designed to manage both mobile and fixed open source meteorological and environmental sensors, in order to integrate the existing agro-meteorological and urban monitoring networks. The proposed architecture uses open source tools to ensure sustainability in the development and deployment of web applications with geographic features and custom analysis, as requested

  6. A hard lesson for Europeans: the ASEAN CDC.

    PubMed

    Tibayrenc, Michel

    2005-06-01

    Despite the growing threat of major pandemics, the European Union is planning no more than a meager surveillance agency staffed with 70 people on the 2007 horizon: the new European Centre for Disease Control. I argue that an effective structure should be much larger and include a strong research activity. Asian countries, inspired by the US CDC, are now taking this concept in hand and creating an ASEAN Center For Disease Control, with sophisticated laboratory facilities to be included. This is a tough lesson for us Europeans, and our avarice in this domain could have tragic consequences in the future.

  7. Review of access, licenses and understandability of open datasets used in hydrology research

    NASA Astrophysics Data System (ADS)

    Falkenroth, Esa; Arheimer, Berit; Lagerbäck Adolphi, Emma

    2015-04-01

    The amount of open data available for hydrology research is continually growing. In the EU-funded project SWITCH-ON (Sharing Water-related Information to Tackle Changes in the Hydrosphere - for Operational Needs), we are addressing water concerns by exploring and exploiting the untapped potential of these new open data. This work is enabled by many ongoing efforts to facilitate the use of open data. For instance, a number of portals (such as the GEOSS Portal and the INSPIRE community geoportal) provide the means to search for such open data sets and open spatial data services. However, in general, the systematic use of available open data is still fairly uncommon in hydrology research. Factors that limits (re)usability of a data set include: (1) accessibility, (2) understandability and (3) licences. If you cannot access the data set, you cannot use if for research. If you cannot understand the data set you cannot use it for research. Finally, if you are not permitted to use the data, you cannot use it for research. Early on in the project, we sent out a questionnaire to our research partners (SMHI, Universita di Bologna, University of Bristol, Technische Universiteit Delft and Technische Universitaet Wien) to find out what data sets they were planning to use in their experiments. The result was a comprehensive list of useful open data sets. Later, this list of data sets was extended with additional information on data sets for planned commercial water-information products and services. With the list of 50 common data sets as a starting point, we reviewed issues related to access, understandability and licence conditions. Regarding access to data sets, a majority of data sets were available through direct internet download via some well-known transfer protocol such as ftp or http. However, several data sets were found to be inaccessible due to server downtime, incorrect links or problems with the host database management system. One possible explanation for this

  8. Characterization of a Drosophila Ortholog of the Cdc7 Kinase

    PubMed Central

    Stephenson, Robert; Hosler, Marcus R.; Gavande, Navnath S.; Ghosh, Arun K.; Weake, Vikki M.

    2015-01-01

    Cdc7 is a serine-threonine kinase that phosphorylates components of the pre-replication complex during DNA replication initiation. Cdc7 is highly conserved, and Cdc7 orthologs have been characterized in organisms ranging from yeast to humans. Cdc7 is activated specifically during late G1/S phase by binding to its regulatory subunit, Dbf4. Drosophila melanogaster contains a Dbf4 ortholog, Chiffon, which is essential for chorion amplification in Drosophila egg chambers. However, no Drosophila ortholog of Cdc7 has yet been characterized. Here, we report the functional and biochemical characterization of a Drosophila ortholog of Cdc7. Co-expression of Drosophila Cdc7 and Chiffon is able to complement a growth defect in yeast containing a temperature-sensitive Cdc7 mutant. Cdc7 and Chiffon physically interact and can be co-purified from insect cells. Cdc7 phosphorylates the known Cdc7 substrates Mcm2 and histone H3 in vitro, and Cdc7 kinase activity is stimulated by Chiffon and inhibited by the Cdc7-specific inhibitor XL413. Drosophila egg chamber follicle cells deficient for Cdc7 have a defect in two types of DNA replication, endoreplication and chorion gene amplification. However, follicle cells deficient for Chiffon have a defect in chorion gene amplification but still undergo endocycling. Our results show that Cdc7 interacts with Chiffon to form a functional Dbf4-dependent kinase complex and that Cdc7 is necessary for DNA replication in Drosophila egg chamber follicle cells. Additionally, we show that Chiffon is a member of an expanding subset of DNA replication initiation factors that are not strictly required for endoreplication in Drosophila. PMID:25451925

  9. New Zealand Seismographic Information Service --- Enhanced Access to Seismographic Data for Research and Teaching

    NASA Astrophysics Data System (ADS)

    Grimwood, P.; Behr, Y.; Townend, J.; Hine, J.; Savage, M.

    2008-12-01

    We are developing web services that facilitate rapid access to New Zealand's seismographic data via the high-speed Kiwi Advanced Research and Education Network (KAREN) to facilitate research and teaching in New Zealand and internationally. Currently, approximately 3.5 GB of continuous broad-band seismographic data --- as well as strong-motion records, geodetic deformation measurements, and volcano and tsunami data --- are collected and archived daily by the GeoNet geophysical monitoring network. These data are increasingly used by educators and researchers around the world. Current requests for seismographic data are handled by an email-based system, "AutoDRM", which does not integrate well with modern cyber- infrastructure or data demands: the system does not readily cope with large data requests such as "give me a year's data from every station in the network, please", and has a limited range of output formats. The new Seismographic Information Service is based on a flexible, service-oriented architecture and standards-based web services. It provides access to archived seismographic data in a range of output formats and waveform durations. Within New Zealand, the data are transmitted over the KAREN network at rates of up to 10 gigabits per second. As part of an ongoing ambient noise correlation tomographic study of the New Zealand plate boundary, these services are being integrated with grid-based computational workflow models to allow large-scale distributed data processing (deconvolution) and cross-correlation.

  10. NASA's Astromaterials Database: Enabling Research Through Increased Access to Sample Data, Metadata and Imagery

    NASA Technical Reports Server (NTRS)

    Evans, Cindy; Todd, Nancy

    2014-01-01

    The Astromaterials Acquisition & Curation Office at NASA's Johnson Space Center (JSC) is the designated facility for curating all of NASA's extraterrestrial samples. Today, the suite of collections includes the lunar samples from the Apollo missions, cosmic dust particles falling into the Earth's atmosphere, meteorites collected in Antarctica, comet and interstellar dust particles from the Stardust mission, asteroid particles from Japan's Hayabusa mission, solar wind atoms collected during the Genesis mission, and space-exposed hardware from several missions. To support planetary science research on these samples, JSC's Astromaterials Curation Office hosts NASA's Astromaterials Curation digital repository and data access portal [http://curator.jsc.nasa.gov/], providing descriptions of the missions and collections, and critical information about each individual sample. Our office is designing and implementing several informatics initiatives to better serve the planetary research community. First, we are re-hosting the basic database framework by consolidating legacy databases for individual collections and providing a uniform access point for information (descriptions, imagery, classification) on all of our samples. Second, we continue to upgrade and host digital compendia that summarize and highlight published findings on the samples (e.g., lunar samples, meteorites from Mars). We host high resolution imagery of samples as it becomes available, including newly scanned images of historical prints from the Apollo missions. Finally we are creating plans to collect and provide new data, including 3D imagery, point cloud data, micro CT data, and external links to other data sets on selected samples. Together, these individual efforts will provide unprecedented digital access to NASA's Astromaterials, enabling preservation of the samples through more specific and targeted requests, and supporting new planetary science research and collaborations on the samples.

  11. Montreal Archive of Sleep Studies: an open-access resource for instrument benchmarking and exploratory research.

    PubMed

    O'Reilly, Christian; Gosselin, Nadia; Carrier, Julie; Nielsen, Tore

    2014-12-01

    Manual processing of sleep recordings is extremely time-consuming. Efforts to automate this process have shown promising results, but automatic systems are generally evaluated on private databases, not allowing accurate cross-validation with other systems. In lacking a common benchmark, the relative performances of different systems are not compared easily and advances are compromised. To address this fundamental methodological impediment to sleep study, we propose an open-access database of polysomnographic biosignals. To build this database, whole-night recordings from 200 participants [97 males (aged 42.9 ± 19.8 years) and 103 females (aged 38.3 ± 18.9 years); age range: 18-76 years] were pooled from eight different research protocols performed in three different hospital-based sleep laboratories. All recordings feature a sampling frequency of 256 Hz and an electroencephalography (EEG) montage of 4-20 channels plus standard electro-oculography (EOG), electromyography (EMG), electrocardiography (ECG) and respiratory signals. Access to the database can be obtained through the Montreal Archive of Sleep Studies (MASS) website (http://www.ceams-carsm.ca/en/MASS), and requires only affiliation with a research institution and prior approval by the applicant's local ethical review board. Providing the research community with access to this free and open sleep database is expected to facilitate the development and cross-validation of sleep analysis automation systems. It is also expected that such a shared resource will be a catalyst for cross-centre collaborations on difficult topics such as improving inter-rater agreement on sleep stage scoring.

  12. NASA's Astromaterials Curation Digital Repository: Enabling Research Through Increased Access to Sample Data, Metadata and Imagery

    NASA Astrophysics Data System (ADS)

    Evans, C. A.; Todd, N. S.

    2014-12-01

    The Astromaterials Acquisition & Curation Office at NASA's Johnson Space Center (JSC) is the designated facility for curating all of NASA's extraterrestrial samples. Today, the suite of collections includes the lunar samples from the Apollo missions, cosmic dust particles falling into the Earth's atmosphere, meteorites collected in Antarctica, comet and interstellar dust particles from the Stardust mission, asteroid particles from Japan's Hayabusa mission, solar wind atoms collected during the Genesis mission, and space-exposed hardware from several missions. To support planetary science research on these samples, JSC's Astromaterials Curation Office hosts NASA's Astromaterials Curation digital repository and data access portal [http://curator.jsc.nasa.gov/], providing descriptions of the missions and collections, and critical information about each individual sample. Our office is designing and implementing several informatics initiatives to better serve the planetary research community. First, we are re-hosting the basic database framework by consolidating legacy databases for individual collections and providing a uniform access point for information (descriptions, imagery, classification) on all of our samples. Second, we continue to upgrade and host digital compendia that summarize and highlight published findings on the samples (e.g., lunar samples, meteorites from Mars). We host high resolution imagery of samples as it becomes available, including newly scanned images of historical prints from the Apollo missions. Finally we are creating plans to collect and provide new data, including 3D imagery, point cloud data, micro CT data, and external links to other data sets on selected samples. Together, these individual efforts will provide unprecedented digital access to NASA's Astromaterials, enabling preservation of the samples through more specific and targeted requests, and supporting new planetary science research and collaborations on the samples.

  13. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Form Letter-Conditions Governing Access to... Letter—Conditions Governing Access to Official Records for Historical Research Purposes Date: OSD Records... depending on whether the information is classified Confidential, Secret, or Top Secret, respectively....

  14. 34 CFR 75.740 - Protection of and access to student records; student rights in research, experimental programs...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Protection of and access to student records; student... Grantee? Privacy § 75.740 Protection of and access to student records; student rights in research, experimental programs, and testing. (a) Most records on present or past students are subject to...

  15. 34 CFR 76.740 - Protection of and access to student records; student rights in research, experimental programs...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Protection of and access to student records; student... of the State and Its Subgrantees? Privacy § 76.740 Protection of and access to student records; student rights in research, experimental programs, and testing. (a) Most records on present or...

  16. 36 CFR 1256.80 - How does NARA provide classified access to historical researchers and former Presidential...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ACCESS TO RECORDS AND DONATED HISTORICAL MATERIALS Access to Materials Containing National Security... historical research projects or previously occupied policy-making positions to which they were appointed by the President. If you seek permission to examine materials under this special historical...

  17. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC ethical requirements. 120.851 Section 120.851 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and...

  18. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC ethical requirements. 120.851 Section 120.851 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and...

  19. Structure and developmental expression of the chicken CDC2 kinase.

    PubMed Central

    Krek, W; Nigg, E A

    1989-01-01

    The cdc2 protein kinase plays a key role in controlling the eukaryotic cell cycle. We have isolated a cDNA clone for the chicken homolog of the cdc2 gene, raised antibodies against the corresponding protein, and studied the expression of cdc2 mRNA and protein during chicken embryonic development. The protein encoded by the chicken cdc2 cDNA shares extensive structural homology with cdc2 gene products from other species. Moreover, when expressed in fission yeast, the chicken cdc2 kinase is able to rescue a temperature-sensitive (ts) cdc2 mutant, demonstrating that it is functional as a cell cycle regulator. By Northern analysis and immunoblotting, we found that in total embryos both cdc2 mRNA and protein levels decreased substantially between day 3 and day 11 after egg laying, and no significant amounts of either cdc2 mRNA or protein were detected in adult liver, brain, heart or skeletal muscle. These data indicate the existence of a coarse correlation between the abundance of cdc2 mRNA and the proliferative state of a given tissue. Interestingly, however, when examining individual embryonic tissues, no correlation was observed between levels of cdc2 mRNA and protein, suggesting that cdc2 expression in developing chicken may be regulated at multiple levels. Images PMID:2684635

  20. 13 CFR 120.851 - CDC ethical requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false CDC ethical requirements. 120.851 Section 120.851 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.851 CDC ethical requirements. CDCs and...

  1. Enhancing Access to Audio and Video Collections of Raman Research Institute Library through Digitization

    NASA Astrophysics Data System (ADS)

    Nagaraj, M. N.; Benegal, V. J.; Bhandi, M. K.

    2015-04-01

    The library at the Raman Research (RRI) began digitization of its audio and video (AV) collections starting in the year 2000 with the intent to enhance the accessibility of these items. AV collections in their original format are problematic since they are vulnerable to physical damage and decay in uncontrolled climate conditions. Further, as AV formats have changed over the years, older formats become unreadable due to the fact that the equipment needed to view such materials is obsolete or no longer available. This paper will show how RRI has taken multiple measures to address these various problems. At first, catalogue records were enhanced with additional metadata, but this did not sufficiently enhance access. Next, the library converted the AV materials to CDs, but this format also posed various problems, as CDs are susceptible to damage and do not allow for multiple simultaneous use. Finally, the RRI library digitized AV materials and placed them on the RRI intranet and the web for wider accessibility.

  2. Differences in Food Environment Perceptions and Spatial Attributes of Food Shopping between Residents of Low and High Food Access Areas

    PubMed Central

    Sohi, Inderbir; Bell, Bethany A.; Liu, Jihong; Battersby, Sarah E.; Liese, Angela D.

    2014-01-01

    Objective To explore potential differences in food shopping behaviors and healthy food availability perceptions between residents living in areas with low and high food access. Design A cross-sectional telephone survey to assess food shopping behaviors and perceptions. Data from an eight-county food environment field census used to define the CDC (Centers for Disease Control and Prevention) healthier food retail tract and USDA ERS (United States Department of Agriculture Economic Research Service) food desert measure. Participants 968 residents in eight South Carolina counties. Main Outcome Measures Residents’ food shopping behaviors and healthy food availability perceptions. Analysis Linear and logistic regression. Results Compared to residents in high food access areas, residents in low food access areas traveled further to their primary food store (USDA ERS: 8.8 vs. 7.1 miles, p=0.03; CDC: 9.2 vs. 6.1 miles, p<0.001), accumulated more total shopping miles per week; CDC 28.0 vs. 15.4 miles, p<0.001) and showed differences in perceived healthy food availability (p<0.001) and shopping access (p<0.001). Conclusions and Implications These findings lend support to ongoing community and policy interventions aimed at reducing food access disparities. PMID:24560861

  3. Experiences accessing public funds for hydrocarbons research and technological development in Mexico

    NASA Astrophysics Data System (ADS)

    Suro-Pérez, V.

    2013-05-01

    The Mexican Petroleum Institute (IMP) is a public facility oriented to research and technological development for the national petroleum industry. Its investment plan and operating expenses come, mainly, from selling engineering services to Petróleos Mexicanos. Its projects include upstream and downstream aspects, and the generated income together with public funds support research projects. These funds were approved since 2005, and widened in 2008 thanks to the so called Energy Reform. Until now, more than 50 projects have been funded, and this presentation shows the process to select, to approve, to fund and to ensure the results promised in the original proposal. It is shown that technical sanction of every particular project is essential to succeed, jointly with a structure of real technical pairs to advise during project development. Likewise, the mechanisms for accessing the funds are described, and simple suggestions are made to improve administrative efficiency.

  4. Cdc48: A Swiss Army Knife of Cell Biology

    PubMed Central

    Baek, Guem Hee; Cheng, Haili; Choe, Vitnary; Bao, Xin; Shao, Jia; Rao, Hai

    2013-01-01

    Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases. PMID:24167726

  5. pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students.

    PubMed

    Campbell, A Malcolm; Eckdahl, Todd; Cronk, Brian; Andresen, Corinne; Frederick, Paul; Huckuntod, Samantha; Shinneman, Claire; Wacker, Annie; Yuan, Jason

    2014-01-01

    The Vision and Change report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area of science. We developed a laboratory module called pClone that empowers students to use advances in molecular cloning methods to discover new promoters for use by synthetic biologists. Our educational goals are consistent with Vision and Change and emphasize core concepts and competencies. pClone is a family of three plasmids that students use to clone a new transcriptional promoter or mutate a canonical promoter and measure promoter activity in Escherichia coli. We also developed the Registry of Functional Promoters, an open-access database of student promoter research results. Using pre- and posttests, we measured significant learning gains among students using pClone in introductory biology and genetics classes. Student posttest scores were significantly better than scores of students who did not use pClone. pClone is an easy and affordable mechanism for large-enrollment labs to meet the high standards of Vision and Change.

  6. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of...

  7. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of...

  8. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of...

  9. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of...

  10. 13 CFR 120.837 - SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... new CDC or for an existing CDC to expand Area of Operations. 120.837 Section 120.837 Business Credit...) Extending A Cdc's Area of Operations § 120.837 SBA decision on application for a new CDC or for an existing CDC to expand Area of Operations. The processing District Office must solicit the comments of...

  11. Facilitating access to pre-processed research evidence in public health

    PubMed Central

    2010-01-01

    Background Evidence-informed decision making is accepted in Canada and worldwide as necessary for the provision of effective health services. This process involves: 1) clearly articulating a practice-based issue; 2) searching for and accessing relevant evidence; 3) appraising methodological rigor and choosing the most synthesized evidence of the highest quality and relevance to the practice issue and setting that is available; and 4) extracting, interpreting, and translating knowledge, in light of the local context and resources, into practice, program and policy decisions. While the public health sector in Canada is working toward evidence-informed decision making, considerable barriers, including efficient access to synthesized resources, exist. Methods In this paper we map to a previously developed 6 level pyramid of pre-processed research evidence, relevant resources that include public health-related effectiveness evidence. The resources were identified through extensive searches of both the published and unpublished domains. Results Many resources with public health-related evidence were identified. While there were very few resources dedicated solely to public health evidence, many clinically focused resources include public health-related evidence, making tools such as the pyramid, that identify these resources, particularly helpful for public health decisions makers. A practical example illustrates the application of this model and highlights its potential to reduce the time and effort that would be required by public health decision makers to address their practice-based issues. Conclusions This paper describes an existing hierarchy of pre-processed evidence and its adaptation to the public health setting. A number of resources with public health-relevant content that are either freely accessible or requiring a subscription are identified. This will facilitate easier and faster access to pre-processed, public health-relevant evidence, with the intent of

  12. NCAR's Research Data Archive: OPeNDAP Access for Complex Datasets

    NASA Astrophysics Data System (ADS)

    Dattore, R.; Worley, S. J.

    2014-12-01

    Many datasets have complex structures including hundreds of parameters and numerous vertical levels, grid resolutions, and temporal products. Making these data accessible is a challenge for a data provider. OPeNDAP is powerful protocol for delivering in real-time multi-file datasets that can be ingested by many analysis and visualization tools, but for these datasets there are too many choices about how to aggregate. Simple aggregation schemes can fail to support, or at least make it very challenging, for many potential studies based on complex datasets. We address this issue by using a rich file content metadata collection to create a real-time customized OPeNDAP service to match the full suite of access possibilities for complex datasets. The Climate Forecast System Reanalysis (CFSR) and it's extension, the Climate Forecast System Version 2 (CFSv2) datasets produced by the National Centers for Environmental Prediction (NCEP) and hosted by the Research Data Archive (RDA) at the Computational and Information Systems Laboratory (CISL) at NCAR are examples of complex datasets that are difficult to aggregate with existing data server software. CFSR and CFSv2 contain 141 distinct parameters on 152 vertical levels, six grid resolutions and 36 products (analyses, n-hour forecasts, multi-hour averages, etc.) where not all parameter/level combinations are available at all grid resolution/product combinations. These data are archived in the RDA with the data structure provided by the producer; no additional re-organization or aggregation have been applied. Since 2011, users have been able to request customized subsets (e.g. - temporal, parameter, spatial) from the CFSR/CFSv2, which are processed in delayed-mode and then downloaded to a user's system. Until now, the complexity has made it difficult to provide real-time OPeNDAP access to the data. We have developed a service that leverages the already-existing subsetting interface and allows users to create a virtual dataset

  13. Cdc28 Activates Exit from Mitosis in Budding Yeast

    PubMed Central

    Rudner, Adam D.; Hardwick, Kevin G.; Murray, Andrew W.

    2000-01-01

    The activity of the cyclin-dependent kinase 1 (Cdk1), Cdc28, inhibits the transition from anaphase to G1 in budding yeast. CDC28-T18V, Y19F (CDC28-VF), a mutant that lacks inhibitory phosphorylation sites, delays the exit from mitosis and is hypersensitive to perturbations that arrest cells in mitosis. Surprisingly, this behavior is not due to a lack of inhibitory phosphorylation or increased kinase activity, but reflects reduced activity of the anaphase-promoting complex (APC), a defect shared with other mutants that lower Cdc28/Clb activity in mitosis. CDC28-VF has reduced Cdc20- dependent APC activity in mitosis, but normal Hct1- dependent APC activity in the G1 phase of the cell cycle. The defect in Cdc20-dependent APC activity in CDC28-VF correlates with reduced association of Cdc20 with the APC. The defects of CDC28-VF suggest that Cdc28 activity is required to induce the metaphase to anaphase transition and initiate the transition from anaphase to G1 in budding yeast. PMID:10871278

  14. Sug1 modulates yeast transcription activation by Cdc68.

    PubMed Central

    Xu, Q; Singer, R A; Johnston, G C

    1995-01-01

    The Cdc68 protein is required for the transcription of a variety of genes in the yeast Saccharomyces cerevisiae. In a search for proteins involved in the activity of the Cdc68 protein, we identified four suppressor genes in which mutations reverse the temperature sensitivity caused by the cdc68-1 allele. We report here the molecular characterization of mutations in one suppressor gene, the previously identified SUG1 gene. The Sug1 protein has been implicated in both transcriptional regulation and proteolysis. sug1 suppressor alleles reversed most aspects of the cdc68-1 mutant phenotype but did not suppress the lethality of a cdc68 null allele, indicating that sug1 suppression is by restoration of Cdc68 activity. Our evidence suggests that suppression by sug1 is unlikely to be due to increased stability of mutant Cdc68 protein, despite the observation that Sug1 affected proteolysis of mutant Cdc68. We report here that attenuated Sug1 activity strengthens mutant Cdc68 activity, whereas increased Sug1 activity further inhibits enfeebled Cdc68 activity, suggesting that Sug1 antagonizes the activator function of Cdc68 for transcription. Consistent with this hypothesis, we find that Sug1 represses transcription in vivo. PMID:7565755

  15. Locally excitable Cdc42 signals steer cells during chemotaxis

    PubMed Central

    Meyer, Tobias

    2016-01-01

    Neutrophils and other amoeboid cells chemotax by steering their front towards chemoattractant. While Ras, Rac, Cdc42, and RhoA small GTPases all regulate chemotaxis, it has been unclear how they spatiotemporally control polarization and steering. Using fluorescence biosensors in neutrophil-like PLB-985 cells and photorelease of chemoattractant, we show that local Cdc42 signals, but not those of Rac, RhoA or Ras, precede cell turning during chemotaxis. Furthermore, preexisting local Cdc42 signals in morphologically unpolarized cells predict the future direction of movement upon uniform stimulation. Moreover, inhibition of actin polymerization uncovers recurring local Cdc42 activity pulses, suggesting that Cdc42 has the excitable characteristic of the compass activity proposed in models of chemotaxis. Globally, Cdc42 antagonizes RhoA, and maintains a steep spatial activity gradient during migration, while Ras and Rac form shallow gradients. Thus, chemotactic steering and de novo polarization are both directed by locally excitable Cdc42 signals. PMID:26689677

  16. Developing an agenda for research about policies to improve access to healthy foods in rural communities: a concept mapping study

    PubMed Central

    2014-01-01

    Background Policies that improve access to healthy, affordable foods may improve population health and reduce health disparities. In the United States most food access policy research focuses on urban communities even though residents of rural communities face disproportionately higher risk for nutrition-related chronic diseases compared to residents of urban communities. The purpose of this study was to (1) identify the factors associated with access to healthy, affordable food in rural communities in the United States; and (2) prioritize a meaningful and feasible rural food policy research agenda. Methods This study was conducted by the Rural Food Access Workgroup (RFAWG), a workgroup facilitated by the Nutrition and Obesity Policy Research and Evaluation Network. A national sample of academic and non-academic researchers, public health and cooperative extension practitioners, and other experts who focus on rural food access and economic development was invited to complete a concept mapping process that included brainstorming the factors that are associated with rural food access, sorting and organizing the factors into similar domains, and rating the importance of policies and research to address these factors. As a last step, RFAWG members convened to interpret the data and establish research recommendations. Results Seventy-five participants in the brainstorming exercise represented the following sectors: non-extension research (n = 27), non-extension program administration (n = 18), “other” (n = 14), policy advocacy (n = 10), and cooperative extension service (n = 6). The brainstorming exercise generated 90 distinct statements about factors associated with rural food access in the United States; these were sorted into 5 clusters. Go Zones were established for the factors that were rated highly as both a priority policy target and a priority for research. The highest ranked policy and research priorities include strategies designed to

  17. ENVRI PLUS: European initiative towards technical and research cultural solutions for across-disciplines accessible Research Infrastructure products

    NASA Astrophysics Data System (ADS)

    Asmi, A.; Kutsch, W. L.

    2015-12-01

    Environmental Research Infrastructures are often built as bottom-up initiatives to provide products for specific target group, which often is very discipline specific. However, the societal or environmental challenges are typically not concentrated on specific disciplines, and require usage of data sets from many RIs. ENVRI PLUS is an initiative where the European environmental RIs work together to provide common technical background (in physical observation technologies and in data products and descriptions) to make the RI products more usable to user groups outside of the original RI target groups. ENVRI PLUS also includes many policy and dissemination concentrated actions to make the RI operations coherent and understandable to both scientists and other potential users. The actions include building common technological capital of the RIs (physical and data-oriented), creating common access procedures (especially for cross-diciplinary access), developing ethical guidelines and related policies, distributing know-how between RIs and building common communication and collaboration system for European environmental RIs. All ENVRI PLUS products are free to use, e.g. for use of new or existing environmental RIs worldwide.

  18. Reducing a suicidal person's access to lethal means of suicide: a research agenda.

    PubMed

    Barber, Catherine W; Miller, Matthew J

    2014-09-01

    Reducing the availability of highly lethal and commonly used suicide methods has been associated with declines in suicide rates of as much as 30%-50% in other countries. The theory and evidence underlying means restriction is outlined. Most evidence of its efficacy comes from population-level interventions and natural experiments. In the U.S., where 51% of suicides are completed with firearms and household firearm ownership is common and likely to remain so, reducing a suicidal person's access to firearms will usually be accomplished not by fiat or other legislative initiative but rather by appealing to individual decision, for example, by counseling at-risk people and their families to temporarily store household firearms away from home or otherwise making household firearms inaccessible to the at-risk person until they have recovered. Providers, gatekeepers, and gun owner groups are important partners in this work. Research is needed in a number of areas: communications research to identify effective messages and messengers for "lethal means counseling," clinical trials to identify effective interventions, translational research to ensure broad uptake of these interventions across clinical and community settings, and foundational research to better understand method choice and substitution. Approaches to suicide methods other than firearms are discussed. Means restriction is one of the few empirically based strategies to substantially reduce the number of suicide deaths.

  19. Reducing a suicidal person's access to lethal means of suicide: a research agenda.

    PubMed

    Barber, Catherine W; Miller, Matthew J

    2014-09-01

    Reducing the availability of highly lethal and commonly used suicide methods has been associated with declines in suicide rates of as much as 30%-50% in other countries. The theory and evidence underlying means restriction is outlined. Most evidence of its efficacy comes from population-level interventions and natural experiments. In the U.S., where 51% of suicides are completed with firearms and household firearm ownership is common and likely to remain so, reducing a suicidal person's access to firearms will usually be accomplished not by fiat or other legislative initiative but rather by appealing to individual decision, for example, by counseling at-risk people and their families to temporarily store household firearms away from home or otherwise making household firearms inaccessible to the at-risk person until they have recovered. Providers, gatekeepers, and gun owner groups are important partners in this work. Research is needed in a number of areas: communications research to identify effective messages and messengers for "lethal means counseling," clinical trials to identify effective interventions, translational research to ensure broad uptake of these interventions across clinical and community settings, and foundational research to better understand method choice and substitution. Approaches to suicide methods other than firearms are discussed. Means restriction is one of the few empirically based strategies to substantially reduce the number of suicide deaths. PMID:25145749

  20. Balancing access to participation in research and protection from risks: applying the principle of justice.

    PubMed

    Kiskaddon, Sarah H

    2005-04-01

    The problem for Institutional Review Boards (IRBs) of balancing access to participation in research with protection of research subjects has always been a difficult one. IRBs, charged with applying the "Common Rule," as well as the Belmont Principles, in their review of clinical research, are given little guidance on approaching this problem. This article argues that the third Belmont Principle, the Justice Principle, may provide a useful framework for considering this balance. The changing research environment is discussed in an historical context, and the Justice Principle is considered both in the context of individual rights, as well as the potential benefit to classes of people. The author further suggests that application of the Justice Principle be driven by findings derived from an analysis of the first 2 principles. This feedback model will enable a more formal application of the Justice Principle and less ambiguous, more transparent, decisions regarding the equitable selection of subjects. The author calls for more systematic attention to the Justice Principle by IRBs, and proposes a model that includes incorporating the deliberation of the other Belmont Principles into the Justice Principle.

  1. Rolling Deck to Repository (R2R): Standards and Semantics for Open Access to Research Data

    NASA Astrophysics Data System (ADS)

    Arko, Robert; Carbotte, Suzanne; Chandler, Cynthia; Smith, Shawn; Stocks, Karen

    2015-04-01

    In recent years, a growing number of funding agencies and professional societies have issued policies calling for open access to research data. The Rolling Deck to Repository (R2R) program is working to ensure open access to the environmental sensor data routinely acquired by the U.S. academic research fleet. Currently 25 vessels deliver 7 terabytes of data to R2R each year, acquired from a suite of geophysical, oceanographic, meteorological, and navigational sensors on over 400 cruises worldwide. R2R is working to ensure these data are preserved in trusted repositories, discoverable via standard protocols, and adequately documented for reuse. R2R maintains a master catalog of cruises for the U.S. academic research fleet, currently holding essential documentation for over 3,800 expeditions including vessel and cruise identifiers, start/end dates and ports, project titles and funding awards, science parties, dataset inventories with instrument types and file formats, data quality assessments, and links to related content at other repositories. A Digital Object Identifier (DOI) is published for 1) each cruise, 2) each original field sensor dataset, 3) each post-field data product such as quality-controlled shiptrack navigation produced by the R2R program, and 4) each document such as a cruise report submitted by the science party. Scientists are linked to personal identifiers, such as the Open Researcher and Contributor ID (ORCID), where known. Using standard global identifiers such as DOIs and ORCIDs facilitates linking with journal publications and generation of citation metrics. Since its inception, the R2R program has worked in close collaboration with other data repositories in the development of shared semantics for oceanographic research. The R2R cruise catalog uses community-standard terms and definitions hosted by the NERC Vocabulary Server, and publishes ISO metadata records for each cruise that use community-standard profiles developed with the NOAA Data

  2. BCO-DMO: Improving Access to Ocean Research Data throughout the Data Life Cycle

    NASA Astrophysics Data System (ADS)

    Chandler, C. L.; Groman, R. C.; Allison, M. D.; Wiebe, P. H.; Glover, D. M.

    2012-12-01

    The Biological and Chemical Oceanography Data Management Office (BCO-DMO) was created in late 2006, by combining the formerly independent data management offices for the U.S. GLOBEC and U.S. JGOFS programs. BCO-DMO staff members work with investigators to publish data from research projects funded by the Biological and Chemical Oceanography Sections and the Office of Polar Programs Antarctic Organisms & Ecosystems Program (OPP ANT) at the U.S. National Science Foundation. Since 2006, researchers have been contributing data to the BCO-DMO data system, and it has developed into a rich repository of data from ocean, coastal and Great Lakes research programs. Data management services are provided at no additional cost to investigators funded by those offices. The main goals of BCO-DMO are to ensure preservation of NSF funded project data and to provide open access to those data. BCO-DMO has developed an end-to-end data stewardship process that includes all phases of the data life cycle: (1) working with investigators at the proposal stage to write their two-page NSF data management plan; (2) registering their funded project at BCO-DMO; (3) adding data and supporting documentation to the BCO-DMO data repository; (4) providing geospatial and text-based data access systems that support data discovery, access, display, assessment, integration, and export of data resources; (5) publication of data sets to provide publishers of the peer-reviewed literature with citable references (Digital Object Identifiers) and to encourage proper citation and attribution of data sets in the future and (6) submission of final data sets for preservation in the appropriate long-term data archive. Recent efforts by BCO-DMO staff members have focused on identifying globally unique, persistent identifiers to unambiguously identify resources of interest that are curated by and available from BCO-DMO. The process involves several essential components: (1) identifying a trusted authoritative source

  3. CDC to CRAY FORTRAN conversion manual

    NASA Technical Reports Server (NTRS)

    Mcgary, C.; Diebert, D.

    1983-01-01

    Documentation describing software differences between two general purpose computers for scientific applications is presented. Descriptions of the use of the FORTRAN and FORTRAN 77 high level programming language on a CDC 7600 under SCOPE and a CRAY XMP under COS are offered. Itemized differences of the FORTRAN language sets of the two machines are also included. The material is accompanied by numerous examples of preferred programming techniques for the two machines.

  4. Complement dependent cytotoxicity (CDC) in chronic lymphocytic leukemia (CLL): Ofatumumab enhances alemtuzumab CDC and reveals cells resistant to activated complement

    PubMed Central

    Baig, Nisar A.; Taylor, Ronald P.; Lindorfer, Margaret A.; Church, Amy K.; LaPlant, Betsy R.; Pavey, Emily S.; Nowakowski, Grzegorz S.; Zent, Clive S.

    2016-01-01

    Complement dependent cytotoxicity (CDC) is an important mechanism of action for monoclonal antibodies (mAb) used in the treatment of chronic lymphocytic leukemia (CLL). We hypothesized that alemtuzumab (ALM) mediated CDC would be increased by addition of ofatumumab (OFA). CLL cells from 21 previously untreated patients with progressive disease were tested in vitro for mAb binding, complement activation, and CDC. The subpopulation of CDC resistant CLL cells was examined for levels of C3b and C5b-9 binding, and expression of complement regulatory proteins. OFA significantly increased complement activation and CDC in ALM-treated CLL cells suggesting that combining ALM and OFA could improve clinical outcome in patients with CLL. Approximately 10% of CLL cells were resistant to CDC because of lower levels of complement activation or decreased cytotoxicity of activated complement. Improvement of clinical responses will require determining the mechanisms of CDC resistance and developing methods to overcome this problem. PMID:22475085

  5. The SCAR Standing Committee on Antarctic Data Management - new directions in access to Antarctic research data

    NASA Astrophysics Data System (ADS)

    de Bruin, T.

    2009-04-01

    The SCAR Standing Committee on Antarctic Data Management (SC-ADM) was established by the Scientific Committee on Antarctic Research (SCAR) and the Council of Managers of National Antarctic Programs (COMNAP), to assist in the fulfillment of the data management obligations imposed by the Antarctic Treaty (section III.1.c): "Scientific observations and results from Antarctica shall be exchanged and made freely available." SC-ADM comprises representatives of the National Antarctic Data Centres or national points of contact. Currently 31 nations around the world are represented in SC-ADM. So far, SC-ADM has been focussing on the coordination of the Antarctic Master Directory (AMD), the internationally accessible, web-based, searchable record of Antarctic and Southern Ocean data set descriptions. The AMD is directly integrated into the international Global Change Master Directory (GCMD) to help further merge Antarctic science into global science. The AMD is a resource for scientists to advertise the data they have collected and to search for data they may need. Currently, SC-ADM is in a transition phase, moving forward to provide data access. Existing systems and web services technology will be used as much as possible, to increase efficiency and prevent 're-inventing the wheel' This poster will give an overview of this process, the current status and the expected results.

  6. Open-Access, Low-Magnetic-Field MRI System for Lung Research

    NASA Technical Reports Server (NTRS)

    Mair, Ross W.; Rosen, Matthew S.; Tsai, Leo L.; Walsworth, Ronald L.; Hrovat, Mirko I.; Patz, Samuel; Ruset, Iullian C.; Hersman, F. William

    2009-01-01

    An open-access magnetic resonance imaging (MRI) system is being developed for use in research on orientational/gravitational effects on lung physiology and function. The open-access geometry enables study of human subjects in diverse orientations. This system operates at a magnetic flux density, considerably smaller than the flux densities of typical other MRI systems, that can be generated by resistive electromagnet coils (instead of the more-expensive superconducting coils of the other systems). The human subject inhales air containing He-3 or Xe-129 atoms, the nuclear spins of which have been polarized by use of a laser beam to obtain a magnetic resonance that enables high-resolution gas space imaging at the low applied magnetic field. The system includes a bi-planar, constant-current, four-coil electromagnet assembly and associated electronic circuitry to apply a static magnetic field of 6.5 mT throughout the lung volume; planar coils and associated circuitry to apply a pulsed magnetic-field-gradient for each spatial dimension; a single, detachable radio-frequency coil and associated circuitry for inducing and detecting MRI signals; a table for supporting a horizontal subject; and electromagnetic shielding surrounding the electromagnet coils.

  7. Summary and Findings of the EPA and CDC Symposium on Air Pollution Exposure and Health

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) and the U.S. Centers for Disease Control (CDC) co-organized a symposium on "Air Pollution Exposure and Health" at Research Triangle Park, North Carolina on September 19–20, 2006. The symposium brought together health and environmenta...

  8. On-Line Help: Design Issues for Authoring Systems. CDC Technical Report No. 18.

    ERIC Educational Resources Information Center

    Duffy, Thomas M.; Langston, M. Diane

    Part of the Communications Design Center's (CDC) on-going research on communication and document design, this report emphasizes the importance of a multi-level computer help system that goes beyond simple command descriptions to include assistance with goals and strategies within the application domain--in this case, automated authoring. The help…

  9. Access to Basic Education in Ghana: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 42

    ERIC Educational Resources Information Center

    Little, Angela W.

    2010-01-01

    This monograph examines the history and politics of educational reform in Ghana. Using data from interviews conducted with senior policy-makers, implementers and researchers, as well as documentary sources, to explore the drivers and inhibitors of change at the political, bureaucratic and grass-roots levels. The monograph explores the nature of…

  10. Access to the NCAR Research Data Archive via the Globus Data Transfer Service

    NASA Astrophysics Data System (ADS)

    Cram, T.; Schuster, D.; Ji, Z.; Worley, S. J.

    2014-12-01

    The NCAR Research Data Archive (RDA; http://rda.ucar.edu) contains a large and diverse collection of meteorological and oceanographic observations, operational and reanalysis outputs, and remote sensing datasets to support atmospheric and geoscience research. The RDA contains greater than 600 dataset collections which support the varying needs of a diverse user community. The number of RDA users is increasing annually, and the most popular method used to access the RDA data holdings is through web based protocols, such as wget and cURL based scripts. In the year 2013, 10,000 unique users downloaded greater than 820 terabytes of data from the RDA, and customized data products were prepared for more than 29,000 user-driven requests. In order to further support this increase in web download usage, the RDA is implementing the Globus data transfer service (www.globus.org) to provide a GridFTP data transfer option for the user community. The Globus service is broadly scalable, has an easy to install client, is sustainably supported, and provides a robust, efficient, and reliable data transfer option for RDA users. This paper highlights the main functionality and usefulness of the Globus data transfer service for accessing the RDA holdings. The Globus data transfer service, developed and supported by the Computation Institute at The University of Chicago and Argonne National Laboratory, uses the GridFTP as a fast, secure, and reliable method for transferring data between two endpoints. A Globus user account is required to use this service, and data transfer endpoints are defined on the Globus web interface. In the RDA use cases, the access endpoint is created on the RDA data server at NCAR. The data user defines the receiving endpoint for the data transfer, which can be the main file system at a host institution, a personal work station, or laptop. Once initiated, the data transfer runs as an unattended background process by Globus, and Globus ensures that the transfer is

  11. Open Access to Physics and Astronomy Theses: A Case Study of the Raman Research Institute Digital Repository

    NASA Astrophysics Data System (ADS)

    Nagaraj, M. N.; Manjunath, M.; Savanur, K. P.; Sheshadri, G.

    2010-10-01

    With the introduction of information technology (IT) and its applications, libraries have started looking for ways to promote their institutes' research output. At the Raman Research Institute (RRI), we have showcased research output such as research papers, newspaper clippings, annual reports, technical reports, and the entire collection of C.V. Raman through the RRI digital repository, using DSpace. Recently, we have added doctoral dissertations to the repository and have made them accessible with the author's permission. In this paper, we describe the challenges and problems encountered in this project. The various stages including policy decisions, the scanning process, getting permissions, metadata standards and other related issues are described. We conclude by making a plea to other institutions also to make their theses available open-access so that this valuable information resource is accessible to all.

  12. Useful, Used, and Peer Approved: The Importance of Rigor and Accessibility in Postsecondary Research and Evaluation. WISCAPE Viewpoints

    ERIC Educational Resources Information Center

    Vaade, Elizabeth; McCready, Bo

    2012-01-01

    Traditionally, researchers, policymakers, and practitioners have perceived a tension between rigor and accessibility in quantitative research and evaluation in postsecondary education. However, this study indicates that both producers and consumers of these studies value high-quality work and clear findings that can reach multiple audiences. The…

  13. Open Access to Field Research: Engaging the General Public and Dispelling Misconceptions

    NASA Astrophysics Data System (ADS)

    Egger, A. E.

    2005-12-01

    The general public holds many misconceptions about the geosciences. Often, people confuse geologists with archaeologists, or believe geoscience careers are limited to petroleum and/or mineral exploration. People in resource-rich areas may have had only negative experiences with geoscientists, where resource extraction has come at the expense of quality of life and property. These misconceptions and negative perceptions are serious threats that can result in uninformed and biased teaching of the geosciences. To address these threats, the true nature and relevance of the geosciences need to be communicated to students and the general public whenever possible. Field work, an essential component of geoscience research and education, offers an ideal opportunity for such communication by bringing researchers and students in direct contact with private citizens and local agencies. By providing open access to field research, a meaningful outreach opportunity can be seamlessly integrated into a research program. Encouraging all students and the general public to participate in field-based research activities can promote understanding of the scientific process, the nature of the geosciences, and the importance of scientific research to a wide variety of audiences, dispelling misconceptions. For a field project conducted in the Warner Range of northeastern California, we initially had two goals: to corroborate an NSF-funded seismic experiment with surface geologic mapping, and to offer a research opportunity for undergraduates. The nature of a seismic experiment necessitates extensive communication with local citizens and agencies. This logistical communication soon led us to add more goals to the project: to conduct outreach activities in the small, rural communities in and around the field area and to collaborate with the many researchers from multiple institutions and government agencies with projects in the region. These outreach and collaboration efforts have now become

  14. The theory research of multi-user quantum access network with Measurement Device Independent quantum key distribution

    NASA Astrophysics Data System (ADS)

    Ji, Yi-Ming; Li, Yun-Xia; Shi, Lei; Meng, Wen; Cui, Shu-Min; Xu, Zhen-Yu

    2015-10-01

    Quantum access network can't guarantee the absolute security of multi-user detector and eavesdropper can get access to key information through time-shift attack and other ways. Measurement-device-independent quantum key distribution is immune from all the detection attacks, and accomplishes the safe sharing of quantum key. In this paper, that Measurement-device-independent quantum key distribution is used in the application of multi-user quantum access to the network is on the research. By adopting time-division multiplexing technology to achieve the sharing of multiuser detector, the system structure is simplified and the security of quantum key sharing is acquired.

  15. Identification and Access Management: An Action Research Approach to Develop a Training Strategy for Higher Education

    ERIC Educational Resources Information Center

    San Nicolas-Rocca, Tonia

    2010-01-01

    Identification and access management has been among the top security issues facing institutions of higher education. Most institutions of higher education require end users to provide usernames and passwords to gain access to personally identifiable information (PII). This leaves universities vulnerable to unauthorized access and unauthorized…

  16. cdc-25.2, a C. elegans ortholog of cdc25, is required to promote oocyte maturation.

    PubMed

    Kim, Jiyoung; Kawasaki, Ichiro; Shim, Yhong-Hee

    2010-03-15

    Cdc25 is an evolutionarily conserved protein phosphatase that promotes progression through the cell cycle. Some metazoans have multiple isoforms of Cdc25, which have distinct functions and different expression patterns during development. C. elegans has four cdc-25 genes. cdc-25.1 is required for germline mitotic proliferation. To determine if the other members of the cdc-25 family also contribute to regulation of cell division in the germ line, we examined phenotypes of loss-of-function mutants of the other cdc-25 family genes. We found that cdc-25.2 is also essential for germline development. cdc-25.2 homozygous mutant hermaphrodites exhibited sterility as a result of defects in oogenesis: mutant oocytes were arrested as endomitotic oocytes that were not fertilized successfully. Spermatogenesis and male germline development were not affected. Through genetic interaction studies, we found that CDC-25.2 functions upstream of maturation-promoting factor containing CDK-1 and CYB-3 to promote oocyte maturation by counteracting function of WEE-1.3. We propose that cdc-25 family members function as distinct but related cell cycle regulators to control diverse cell cycles in C. elegans germline development.

  17. Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

    PubMed Central

    Chang, FuJung; Riera, Alberto; Evrin, Cecile; Sun, Jingchuan; Li, Huilin; Speck, Christian; Weinreich, Michael

    2015-01-01

    To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this reaction is still incompletely understood. Here, we show that although Cdc6 ATP hydrolysis is essential to initiate DNA replication, it is not essential for MCM loading. Using purified proteins, an ATPase-defective Cdc6 mutant ‘Cdc6-E224Q’ promoted MCM loading on DNA. Cdc6-E224Q also promoted MCM binding at origins in vivo but cells remained blocked in G1-phase. If after loading MCM, Cdc6-E224Q was degraded, cells entered an apparently normal S-phase and replicated DNA, a phenotype seen with two additional Cdc6 ATPase-defective mutants. Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-RC after helicase loading to advance subsequent steps in helicase activation in vivo. DOI: http://dx.doi.org/10.7554/eLife.05795.001 PMID:26305410

  18. Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

    PubMed

    Chang, FuJung; Riera, Alberto; Evrin, Cecile; Sun, Jingchuan; Li, Huilin; Speck, Christian; Weinreich, Michael

    2015-08-25

    To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this reaction is still incompletely understood. Here, we show that although Cdc6 ATP hydrolysis is essential to initiate DNA replication, it is not essential for MCM loading. Using purified proteins, an ATPase-defective Cdc6 mutant 'Cdc6-E224Q' promoted MCM loading on DNA. Cdc6-E224Q also promoted MCM binding at origins in vivo but cells remained blocked in G1-phase. If after loading MCM, Cdc6-E224Q was degraded, cells entered an apparently normal S-phase and replicated DNA, a phenotype seen with two additional Cdc6 ATPase-defective mutants. Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-RC after helicase loading to advance subsequent steps in helicase activation in vivo.

  19. Supporting the whole student: Inclusive program design for making undergraduate research experiences accessible

    NASA Astrophysics Data System (ADS)

    Haacker-Santos, R.; Allen, L.; Batchelor, R. L.

    2013-12-01

    As undergraduate research experiences have become an unofficial pre-requisite to enter graduate school programs in the sciences, we have to make sure that these experiences are inclusive and accessible to all students. Program managers who make a conscious effort to recruit students from traditionally under-represented groups, including veterans, non-traditional students or students with disabilities, are often unaware of the financial and program implications these students require, and discover that their current program design might inadvertently exclude or not fully support these students. The SOARS Program, an undergraduate-to-graduate bridge program in the atmospheric sciences, has supported this group of students for over 15 years. We have found that we needed to adjust some program elements and secure extra funding sources to holistically support our students in their research experience, however, the program and the students have reaped tremendous benefits. Involving non-traditional students or veterans in our program has raised the maturity level and problem solving skills of the group, and having students with disabilities participate has been a vehicle for broadening perspective and diverse knowledge into the field of study, e.g. researching weather and climate beyond what you can 'see'. This presentation will highlight some of the findings from the SOARS program experience, and will share practices for recruitment and holistic support to ensure student success. We will share resources and tips on inclusive program design, including working with students with family commitments or physical disabilities, and will report on the enormous program benefits and peer learning these students have brought to the student cohorts and research labs they are working in.

  20. The Virtual Skeleton Database: An Open Access Repository for Biomedical Research and Collaboration

    PubMed Central

    Bonaretti, Serena; Pfahrer, Marcel; Niklaus, Roman; Büchler, Philippe

    2013-01-01

    Background Statistical shape models are widely used in biomedical research. They are routinely implemented for automatic image segmentation or object identification in medical images. In these fields, however, the acquisition of the large training datasets, required to develop these models, is usually a time-consuming process. Even after this effort, the collections of datasets are often lost or mishandled resulting in replication of work. Objective To solve these problems, the Virtual Skeleton Database (VSD) is proposed as a centralized storage system where the data necessary to build statistical shape models can be stored and shared. Methods The VSD provides an online repository system tailored to the needs of the medical research community. The processing of the most common image file types, a statistical shape model framework, and an ontology-based search provide the generic tools to store, exchange, and retrieve digital medical datasets. The hosted data are accessible to the community, and collaborative research catalyzes their productivity. Results To illustrate the need for an online repository for medical research, three exemplary projects of the VSD are presented: (1) an international collaboration to achieve improvement in cochlear surgery and implant optimization, (2) a population-based analysis of femoral fracture risk between genders, and (3) an online application developed for the evaluation and comparison of the segmentation of brain tumors. Conclusions The VSD is a novel system for scientific collaboration for the medical image community with a data-centric concept and semantically driven search option for anatomical structures. The repository has been proven to be a useful tool for collaborative model building, as a resource for biomechanical population studies, or to enhance segmentation algorithms. PMID:24220210

  1. Polarity establishment requires localized activation of Cdc42

    PubMed Central

    Woods, Benjamin; Kuo, Chun-Chen; Wu, Chi-Fang; Zyla, Trevin R.

    2015-01-01

    Establishment of cell polarity in animal and fungal cells involves localization of the conserved Rho-family guanosine triphosphatase, Cdc42, to the cortical region destined to become the “front” of the cell. The high local concentration of active Cdc42 promotes cytoskeletal polarization through various effectors. Cdc42 accumulation at the front is thought to involve positive feedback, and studies in the budding yeast Saccharomyces cerevisiae have suggested distinct positive feedback mechanisms. One class of mechanisms involves localized activation of Cdc42 at the front, whereas another class involves localized delivery of Cdc42 to the front. Here we show that Cdc42 activation must be localized for successful polarity establishment, supporting local activation rather than local delivery as the dominant mechanism in this system. PMID:26459595

  2. Peer-review and publication of research protocols and proposals: a role for open access journals.

    PubMed

    Eysenbach, Gunther

    2004-09-30

    Peer-review and publication of research protocols offer several advantages to all parties involved. Among these are the following opportunities for authors: external expert opinion on the methods, demonstration to funding agencies of prior expert review of the protocol, proof of priority of ideas and methods, and solicitation of potential collaborators. We think that review and publication of protocols is an important role for Open Access journals. Because of their electronic form, openness for readers, and author-pays business model, they are better suited than traditional journals to ensure the sustainability and quality of protocol reviews and publications. In this editorial, we describe the workflow for investigators in eHealth research, from protocol submission to a funding agency, to protocol review and (optionally) publication at JMIR, to registration of trials at the International eHealth Study Registry (IESR), and to publication of the report. One innovation at JMIR is that protocol peer reviewers will be paid a honorarium, which will be drawn partly from a new submission fee for protocol reviews. Separating the article processing fee into a submission and a publishing fee will allow authors to opt for "peer-review only" (without subsequent publication) at reduced costs, if they wish to await a funding decision or for other reasons decide not to make the protocol public. PMID:15471763

  3. StemBANCC: Governing Access to Material and Data in a Large Stem Cell Research Consortium.

    PubMed

    Morrison, Michael; Klein, Christine; Clemann, Nicole; Collier, David A; Hardy, John; Heisserer, Barbara; Cader, M Zameel; Graf, Martin; Kaye, Jane

    2015-10-01

    This paper makes the case for implementing an internal governance framework for sharing materials and data in stem cell research consortia. A governance framework can facilitate a transparent and accountable system while building trust among partner institutions. However, avoiding excessive bureaucracy is essential. The development and implementation of a governance framework for materials and data access in the Stem cells for Biological Assays of Novel drugs and prediCtive toxiCology (StemBANCC) consortium is presented as a practical example. The StemBANCC project is a multi-partner European research consortium, which aims to build a resource of 1,500 well characterised induced pluripotent stem cell (iPSC) lines for in vitro disease modelling and toxicology studies. The project governance framework was developed in two stages. A small working group identified key components of a framework and translated the project legal agreements into a draft policy document. The second phase allowed input from all consortium partners to shape the iterative development of a final policy document that could be agreed by all parties. Careful time management strategies were needed to manage the duration of this component. This part of the process also served as an exploratory space where different options could be proposed, potential gaps in planning identified, and project co-ordination activities specified.

  4. Do Croatian open access journals support ethical research? Content analysis of instructions to authors

    PubMed Central

    Stojanovski, Jadranka

    2015-01-01

    Introduction The aim of our study was to investigate the extent to which Instructions to authors of the Croatian open access (OA) journals are addressing ethical issues. Do biomedical journals differ from the journals from other disciplines in that respect? Our hypothesis was that biomedical journals maintain much higher publication ethics standards. Materials and methods This study looked at 197 Croatian OA journals Instructions to authors to address the following groups of ethical issues: general terms; guidelines and recommendations; research approval and registration; funding and conflict of interest; peer review; redundant publications, misconduct and retraction; copyright; timeliness; authorship; and data accessibility. We further compared a subset of 159 non-biomedical journals with a subset of 38 biomedical journals. Content analysis was used to discern the ethical issues representation in the instructions to authors. Results The groups of biomedical and non-biomedical journals were similar in terms of originality (χ2 = 2.183, P = 0.140), peer review process (χ2 = 0.296, P = 0.586), patent/grant statement (χ2 = 2.184, P = 0.141), and timeliness of publication (χ2 = 0.369, P = 0.544). We identified significant differences among categories including ethical issues typical for the field of biomedicine, like patients (χ2 = 47.111, P < 0.001), and use of experimental animals (χ2 = 42.543, P < 0.001). Biomedical journals also rely on international editorial guidelines formulated by relevant professional organizations heavily, compared with non-biomedical journals (χ2 = 42.666, P < 0.001). Conclusion Low representation or absence of some key ethical issues in author guidelines calls for more attention to the structure and the content of Instructions to authors in Croatian OA journals. PMID:25672463

  5. Making science accessible through collaborative science teacher action research on feminist pedagogy

    NASA Astrophysics Data System (ADS)

    Capobianco, Brenda M.

    research. This study revealed that there are no uniform solutions or standard methods to address issues of equity and accessibility in science education. This study recommends teachers be given time, support, and freedom to collaborate with other teacher-researchers, enact decisions for change, and reflect on and make public the results of their work. Additional implications suggest science teacher educators collaborate with practicing science teachers to devise practical applications and feasible resources for a wider audience.

  6. Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys

    PubMed Central

    Choi, Soo Young; Chacon-Heszele, Maria F.; Huang, Liwei; McKenna, Sarah; Wilson, F. Perry; Zuo, Xiaofeng

    2013-01-01

    Ciliogenesis and cystogenesis require the exocyst, a conserved eight-protein trafficking complex that traffics ciliary proteins. In culture, the small GTPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst component Sec10. The role of Cdc42 in vivo, however, is not well understood. Here, knockdown of cdc42 in zebrafish produced a phenotype similar to sec10 knockdown, including tail curvature, glomerular expansion, and mitogen-activated protein kinase (MAPK) activation, suggesting that cdc42 and sec10 cooperate in ciliogenesis. In addition, cdc42 knockdown led to hydrocephalus and loss of photoreceptor cilia. Furthermore, there was a synergistic genetic interaction between zebrafish cdc42 and sec10, suggesting that cdc42 and sec10 function in the same pathway. Mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth. Histology revealed cystogenesis in distal tubules and collecting ducts, decreased ciliogenesis in cyst cells, increased tubular cell proliferation, increased apoptosis, increased fibrosis, and led to MAPK activation, all of which are features of polycystic kidney disease, especially nephronophthisis. Taken together, these results suggest that Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carrying ciliary proteins. Abnormalities in this pathway result in deranged ciliogenesis and polycystic kidney disease. PMID:23766535

  7. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.

    PubMed

    Choi, Soo Young; Chacon-Heszele, Maria F; Huang, Liwei; McKenna, Sarah; Wilson, F Perry; Zuo, Xiaofeng; Lipschutz, Joshua H

    2013-09-01

    Ciliogenesis and cystogenesis require the exocyst, a conserved eight-protein trafficking complex that traffics ciliary proteins. In culture, the small GTPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst component Sec10. The role of Cdc42 in vivo, however, is not well understood. Here, knockdown of cdc42 in zebrafish produced a phenotype similar to sec10 knockdown, including tail curvature, glomerular expansion, and mitogen-activated protein kinase (MAPK) activation, suggesting that cdc42 and sec10 cooperate in ciliogenesis. In addition, cdc42 knockdown led to hydrocephalus and loss of photoreceptor cilia. Furthermore, there was a synergistic genetic interaction between zebrafish cdc42 and sec10, suggesting that cdc42 and sec10 function in the same pathway. Mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth. Histology revealed cystogenesis in distal tubules and collecting ducts, decreased ciliogenesis in cyst cells, increased tubular cell proliferation, increased apoptosis, increased fibrosis, and led to MAPK activation, all of which are features of polycystic kidney disease, especially nephronophthisis. Taken together, these results suggest that Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carrying ciliary proteins. Abnormalities in this pathway result in deranged ciliogenesis and polycystic kidney disease.

  8. Control of ubiquitin conjugation by cdc48 and its cofactors.

    PubMed

    Buchberger, Alexander

    2010-01-01

    Cdc48 (alias p97, VCP) is an important motor and regulator for the turnover of ubiquitylated proteins, both in proteasomal degradation and in nonproteolytic pathways. The diverse cellular tasks of Cdc48 are controlled by a large number of cofactors. Substrate-recruiting cofactors mediate the specific recognition of ubiquitylated target proteins, whereas substrate-processing cofactors often exhibit ubiquitin ligase or deubiquitylating activities that enable them to modulate the ubiquitylation state of substrates. This chapter introduces the major groups of Cdc48 cofactors and discusses the versatile options of substrate-processing cofactors to control the fate of Cdc48 substrates.

  9. P97/CDC-48: proteostasis control in tumor cell biology.

    PubMed

    Fessart, Delphine; Marza, Esther; Taouji, Saïd; Delom, Frédéric; Chevet, Eric

    2013-08-28

    P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.

  10. Action Research to Improve Methods of Delivery and Feedback in an Access Grid Room Environment

    ERIC Educational Resources Information Center

    McArthur, Lynne C.; Klass, Lara; Eberhard, Andrew; Stacey, Andrew

    2011-01-01

    This article describes a qualitative study which was undertaken to improve the delivery methods and feedback opportunity in honours mathematics lectures which are delivered through Access Grid Rooms. Access Grid Rooms are facilities that provide two-way video and audio interactivity across multiple sites, with the inclusion of smart boards. The…

  11. College Access, K-12 Concentrated Disadvantage, and the Next 25 Years of Education Research

    ERIC Educational Resources Information Center

    Yun, John T.; Moreno, Jose F.

    2006-01-01

    Race-inclusive admissions policies are important tools for attaining equitable access to selective colleges and universities. However, access to such institutions does not begin at the point of admissions. Rather, it depends on an interaction between the K-12 system and university admissions policies that may either mitigate inequalities or…

  12. Students' Perceptions of a University Access (Bridging) Programme for Social Science, Commerce and Humanities: Research Article

    ERIC Educational Resources Information Center

    Quayle, Michael; Essack, Zaynab

    2007-01-01

    Universities in South Africa face the challenge of redressing past (and continuing) inequalities in higher education by increasing accessibility to previously (and currently) disadvantaged students. One means of doing so is through 'access' or 'bridging' programmes. This article explores successful students' perceptions of one such programme at…

  13. The Subglacial Access and Fast Ice Research Experiment - SAFIRE - on Store Glacier, West Greenland

    NASA Astrophysics Data System (ADS)

    Christoffersen, P.; Hubbard, B. P.; Doyle, S. H.; Young, T. J.; Hofstede, C. M.; Bougamont, M. H.; Todd, J.; Toberg, N.; Nicholls, K. W.; Box, J.; Walter, J. I.; Hubbard, A.

    2015-12-01

    Marine-terminating outlet glaciers drain 90 percent of the Greenland Ice Sheet and are responsible for about half of the ice sheet's net annual mass loss, which currently raises global sea level by 1 mm per year. The basal controls on these fast-flowing glaciers are, however, poorly understood, with the implication that numerical ice sheet models needed to predict future dynamic ice loss from Greenland relies on uncertain and often untested basal parameterizations. The Subglacial Access and Fast Ice Research Experiment - SAFIRE - is addressing this paucity of observational constraints by drilling to the bed of Store Glacier, a fast-flowing outlet glacier terminating in Uummannaq Fjord, West Greenland. In 2014, we gained access to the bed in four boreholes drilled to depths of 603-616 m near the center of the glacier, 30 km inland from the calving terminus where ice flows at a rate of 700 m/year. A seismic survey showed the glacier bed to consist of water-saturated, soft sediment. The water level in all four boreholes nevertheless dropped rapidly to 80 m below the ice surface when the drill connected with a basal water system, indicating effective drainage over a sedimentary bed. We were able to install wired sensor strings at the bed (water pressure, temperature, electrical conductivity and turbidity) and within the glacier (temperature and tilt) in three boreholes. The sensors operated for up to 80+ days before cables stretched and ultimately snapped due to high internal strain. The data collected during this sensor deployment show ice as cold as -21 degrees Celcius; yet, temperature of water in the basal water system was persistently above the local freezing point. With diurnal variations detected in several sensor records, we hypothesise that surface water lubricates the ice flow while also warming basal ice. The fast basal motion of Store Glacier not only occurs by basal sliding, but from high rates of concentrated strain in the bottom third of the glacier

  14. Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin

    PubMed Central

    Franz, André; Ackermann, Leena; Hoppe, Thorsten

    2016-01-01

    The dynamic composition of proteins associated with nuclear DNA is a fundamental property of chromosome biology. In the chromatin compartment dedicated protein complexes govern the accurate synthesis and repair of the genomic information and define the state of DNA compaction in vital cellular processes such as chromosome segregation or transcription. Unscheduled or faulty association of protein complexes with DNA has detrimental consequences on genome integrity. Consequently, the association of protein complexes with DNA is remarkably dynamic and can respond rapidly to cellular signaling events, which requires tight spatiotemporal control. In this context, the ring-like AAA+ ATPase CDC48/p97 emerges as a key regulator of protein complexes that are marked with ubiquitin or SUMO. Mechanistically, CDC48/p97 functions as a segregase facilitating the extraction of substrate proteins from the chromatin. As such, CDC48/p97 drives molecular reactions either by directed disassembly or rearrangement of chromatin-bound protein complexes. The importance of this mechanism is reflected by human pathologies linked to p97 mutations, including neurodegenerative disorders, oncogenesis, and premature aging. This review focuses on the recent insights into molecular mechanisms that determine CDC48/p97 function in the chromatin environment, which is particularly relevant for cancer and aging research. PMID:27200082

  15. The General Opinion on Accessibility - Research About the Attitudes in Finland.

    PubMed

    Nordlund, Marika; Maunula, Kirsi; Kilpelä, Niina

    2016-01-01

    The public discussion about accessibility in the built environment has been recently very ambivalent in Finland. Finnish Government programme includes 26 key projects and one of them links with deregulation of building legislation. In addition to this, according to the preliminary media analysis carried out by The Finnish Association of People with Physical Disabilities (FPD) the traditional media in Finland seems to give somewhat more support to those opposing accessibility than those supporting it. FPD wanted to find out people's attitudes towards accessibility and the possible disadvantages they see in promoting accessibility. The purpose was to get background information to influence on attitudes and to launch a positive attitude campaign. FPD commissioned a survey about the accessibility in built environment and find out that surprisingly, based on the survey, the opinions of the majority of people are not as negative as expected. PMID:27534277

  16. The Use of the Journal Access Service and Its Implications for Journal Selection at the Center for Research Libraries.

    ERIC Educational Resources Information Center

    Lewis, David W.

    In order to develop guidelines for the selection of journals by the Center for Research Libraries, a study was done of the use made of the Center's Journal Access Services (JAS), which supplies photocopies of journal articles to member institutions from the Center's collections and from the British Library Lending Division (BLLD). Based on a…

  17. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes E Appendix E to Part 197 National Defense Department of... THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. E Appendix E to Part...

  18. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes E Appendix E to Part 197 National Defense Department of... THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. E Appendix E to Part...

  19. Using the Critical Incident Technique to Research Decision Making regarding Access to Training and Development in Medium-Sized Enterprises

    ERIC Educational Resources Information Center

    Coetzer, Alan; Redmond, Janice; Sharafizad, Jalleh

    2012-01-01

    Employees in small and medium-sized enterprises (SMEs) form part of a "disadvantaged" group within the workforce that receives less access to training and development (T&D) than employees in large firms. Prior research into reasons for the relatively low levels of employee participation in training and development has typically involved surveys of…

  20. Filtering Access to Internet Content at Higher Education Institutions: Stakeholder Perceptions and Their Impact on Research and Academic Freedom

    ERIC Educational Resources Information Center

    Orenstein, David I.

    2009-01-01

    Hardware and software filters, which sift through keywords placed in Internet search engines and online databases, work to limit the return of information from these sources. By their very purpose, filters exist to decrease the amount of information researchers can access. The purpose of this study is to gain insight into the perceptions key…

  1. 32 CFR Appendix E to Part 197 - Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Form Letter-Conditions Governing Access to Official Records for Historical Research Purposes E Appendix E to Part 197 National Defense Department of... THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. E Appendix E to Part...

  2. Morphological and physio-chemical characterization of five Canistel accessions at the subtropical horticulture research station in Miami Florida

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fruit of five canistel cultivars, 'Fairchild','E11', 'Keisau', 'TREC#3' and 'TREC 3680' were evaluated and characterized at the National Germplasm Repository, Subtropical horticulture Research Station (SHRS) Miami, Florida. Thirty fruits were harvested from clonal accessions during July and August, ...

  3. CDC Vital Signs: Heart Age - Is Your Heart Older Than You?

    MedlinePlus

    ... Search The CDC Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is not supported ... message, please visit this page: About CDC.gov . Vital Signs Current issue Infographic Topics Covered Alcohol Cancer Cardiovascular ...

  4. 77 FR 12845 - Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Disease, Disability, and Injury... Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (CDC/ATSDR... meetings and other committee management activities, for both the Centers for Disease Control and...

  5. A practical approach to implementing new CDC GBS guidelines.

    PubMed

    Hill, Shawna M; Bridges, Margie A; Knudsen, Alexis L; Vezeau, Toni M

    2013-01-01

    Group beta streptococcus (GBS) is a well-documented pathogen causing serious maternal and fetal morbidity and mortality. The CDC guidelines for managing clients who test positive for GBS in pregnancy were revised and published in 2010. However, CDC and extant literature provide limited guidance on implementation strategies for these new recommendations. Although several algorithms are included in the CDC (2010) document, none combine the maternal risk factors for practical and consistent implementation from pregnancy to newborn. In response to confusion upon initial education of these guidelines, we developed an algorithm for maternal intrapartum management. In addition, we clarified the CDC (2010) newborn algorithm in response to provider request. Without altering the recommendations, both algorithms provide clarification of the CDC (2010) guidelines. The nursing process provides an organizational structure for the discussion of our efforts to translate the complex guidelines into practice. This article could provide other facilities with tools for dealing with specific aspects of the complex clinical management of perinatal GBS.

  6. NCAR Johns Hopkins/CDC Climate and Health Summer Institute

    NASA Technical Reports Server (NTRS)

    Mearns, Linda O.

    2005-01-01

    The interactions between climate and health are rife with complexity and present many conceptual and methodological challenges. Possible effects of climate change on health are considered some of the most sensitive impacts of climate change and are a high priority for policy-makers and the public. As a first step toward improving tlit: quality of research, we developed a Climate and Health Workshop (Institute), geared toward teaching students various aspects of how to conduct integrated climate and health research. At the workshop scientists presented selected case studies of climate and health (e.g., heat mortality, vector-borne diseases), thus demonstrating a subset of key analytical tools and databases most useful to researchers in this field. Key research gaps in this research area were discussed. In this six-day Institute (21-28 July 2004, Boulder, Colorado), health scientists and students benefited from lectures and hands-on tools taught by top NCAR scientists. The attendees learned about health databases and epidemiologic methods from leading health scientists from CDC, Johns Hopkins, and other institutions from around the globe.

  7. Health policy and systems research in access to medicines: a prioritized agenda for low- and middle-income countries

    PubMed Central

    2013-01-01

    Objectives To identify priority policy issues in access to medicines (ATM) relevant for low- and middle-income countries, to identify research questions that would help address these policy issues, and to prioritize these research questions in a health policy and systems research (HPSR) agenda. Methods The study involved i) country- and regional-level priority-setting exercises performed in 17 countries across five regions, with a desk review of relevant grey and published literature combined with mapping and interviews of national and regional stakeholders; ii) interviews with global-level stakeholders; iii) a scoping of published literature; and iv) a consensus building exercise with global stakeholders which resulted in the formulation and ranking of HPSR questions in the field of ATM. Results A list of 18 priority policy issues was established following analysis of country-, regional-, and global-level exercises. Eighteen research questions were formulated during the global stakeholders’ meeting and ranked according to four ranking criteria (innovation, impact on health and health systems, equity, and lack of research). The top three research questions were: i) In risk protection schemes, which innovations and policies improve equitable access to and appropriate use of medicines, sustainability of the insurance system, and financial impact on the insured? ii) How can stakeholders use the information available in the system, e.g., price, availability, quality, utilization, registration, procurement, in a transparent way towards improving access and use of medicines? and iii) How do policies and other interventions into private markets, such as information, subsidies, price controls, donation, regulatory mechanisms, promotion practices, etc., impact on access to and appropriate use of medicines? Conclusions Our HPSR agenda adopts a health systems perspective and will guide relevant, innovative research, likely to bear an impact on health, health systems and

  8. Postoperative infant septicemia caused by Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2).

    PubMed

    Freney, J; Hansen, W; Etienne, J; Vandenesch, F; Fleurette, J

    1988-06-01

    Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2) were both isolated from the same blood culture of a 5-month-old infant, 8 days after open-heart surgery. He quickly responded to appropriate antibiotics. Carbon substrate assimilation tests and fatty acid analysis clearly differentiated these two rarely pathogenic organisms.

  9. Postoperative infant septicemia caused by Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2).

    PubMed

    Freney, J; Hansen, W; Etienne, J; Vandenesch, F; Fleurette, J

    1988-06-01

    Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2) were both isolated from the same blood culture of a 5-month-old infant, 8 days after open-heart surgery. He quickly responded to appropriate antibiotics. Carbon substrate assimilation tests and fatty acid analysis clearly differentiated these two rarely pathogenic organisms. PMID:3384937

  10. Postoperative infant septicemia caused by Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2).

    PubMed Central

    Freney, J; Hansen, W; Etienne, J; Vandenesch, F; Fleurette, J

    1988-01-01

    Pseudomonas luteola (CDC group Ve-1) and Pseudomonas oryzihabitans (CDC group Ve-2) were both isolated from the same blood culture of a 5-month-old infant, 8 days after open-heart surgery. He quickly responded to appropriate antibiotics. Carbon substrate assimilation tests and fatty acid analysis clearly differentiated these two rarely pathogenic organisms. PMID:3384937

  11. The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.

    PubMed Central

    MacNeill, S A; Moreno, S; Reynolds, N; Nurse, P; Fantes, P A

    1996-01-01

    cdc1+ is required for cell cycle progression in Schizosaccharomyces pombe. Cells carrying temperature-sensitive cdc1 mutants undergo cell cycle arrest when shifted to the restrictive temperature, becoming highly elongated. Here we describe the cloning and sequencing of cdc1+, which is shown to encode a 462 residue protein that displays significant sequence similarity to the small subunit of mammalian DNA polymerase delta. cdc1+ interacts genetically with pol3+, which encodes the large subunit of DNA polymerase delta in fission yeast, and the Cdc1 protein binds to Pol3 in vitro, strongly suggesting that Cdc1 is likely to be the small subunit of Pol delta. In addition, we show that cdc1+ overexpression is sufficient to rescue cells carrying temperature-sensitive cdc27 alleles and that the Cdc1 and Cdc27 proteins interact in vivo and in vitro. Deletion of either cdc1+ or cdc27+ results in cell cycle arrest with the arrested cells having a single nucleus with 2C DNA content. No evidence was obtained for a cut phenotype, indicating that neither cdc1+ nor cdc27+ is required for checkpoint function. cdc1 mutant cells are supersensitive to the DNA synthesis inhibitor hydroxyurea and to the DNA damaging agent MMS, display increased frequency of mini-chromosome loss and have an extended S phase. Images PMID:8887553

  12. CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.

    PubMed

    Lee, Yong-Uk; Son, Miseol; Kim, Jiyoung; Shim, Yhong-Hee; Kawasaki, Ichiro

    2016-01-01

    Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine.

  13. CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.

    PubMed

    Lee, Yong-Uk; Son, Miseol; Kim, Jiyoung; Shim, Yhong-Hee; Kawasaki, Ichiro

    2016-01-01

    Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine. PMID:27104746

  14. Seeking to understand: using generic qualitative research to explore access to medicines and pharmacy services among resettled refugees.

    PubMed

    Bellamy, Kim; Ostini, Remo; Martini, Nataly; Kairuz, Therese

    2016-06-01

    Introduction There are challenges associated with selecting a qualitative research approach. In a field abundant with terminology and theories, it may be difficult for a pharmacist to know where and how to begin a qualitative research journey. The purpose of this paper is to provide insight into generic qualitative research and to describe the journey of data collection of a novice qualitative researcher in the quest to answer her research question: 'What are the barriers to accessing medicines and pharmacy services for resettled refugees in Queensland, Australia?' Methodology Generic qualitative research draws on the strengths of one or more qualitative approaches. The aim is to draw out participants' ideas about things that are 'outside themselves'; rather than focussing on their inner feelings the research seeks to understand a phenomenon, a process, or the perspectives of participants. Sampling is designed to obtain a broad range of opinions about events and experiences and data collection includes interviews, questionnaires or surveys; thematic analysis is often used to analyse data. When to use Generic qualitative research provides an opportunity to develop research designs that fit researchers' epistemological stance and discipline, with research choices, including methodology and methods, being informed by the research question. Limitations Generic qualitative research is one of many methodologies that may be used to answer a research question and there is a paucity of literature about how to do it well. There is also debate about its validity as a qualitative methodology.

  15. Efficient, quality-assured data capture in operational research through innovative use of open-access technology.

    PubMed

    Kumar, A M V; Naik, B; Guddemane, D K; Bhat, P; Wilson, N; Sreenivas, A N; Lauritsen, J M; Rieder, H L

    2013-03-21

    Ensuring quality of data during electronic data capture has been one of the most neglected components of operational research. Multicentre studies are also challenged with issues about logistics of travel, training, supervision, monitoring and troubleshooting support. Allocating resources to these issues can pose a significant bottleneck for operational research in resource-limited settings. In this article, we describe an innovative and efficient way of coordinating data capture in multicentre operational research using a combination of three open access technologies-EpiData for data capture, Dropbox for sharing files and TeamViewer for providing remote support.

  16. Nanotechnology researchers' collaboration relationships: a gender analysis of access to scientific information.

    PubMed

    Villanueva-Felez, Africa; Woolley, Richard; Cañibano, Carolina

    2015-02-01

    Women are underrepresented in science, technology, engineering, and mathematics fields, particularly at higher levels of organizations. This article investigates the impact of this underrepresentation on the processes of interpersonal collaboration in nanotechnology. Analyses are conducted to assess: (I) the comparative tie strength of women's and men's collaborations, (2) whether women and men gain equal access to scientific information through collaborators, (3) which tie characteristics are associated with access to information for women and men, and (4) whether women and men acquire equivalent amounts of information by strengthening ties. Our results show that the overall tie strength is less for women's collaborations and that women acquire less strategic information through collaborators. Women and men rely on different tie characteristics in accessing information, but are equally effective in acquiring additional information resources by strengthening ties. This article demonstrates that the underrepresentation of women in science, technology, engineering, and mathematics has an impact on the interpersonal processes of scientific collaboration, to the disadvantage of women scientists.

  17. Action research to improve methods of delivery and feedback in an Access Grid Room environment

    NASA Astrophysics Data System (ADS)

    McArthur, Lynne C.; Klass, Lara; Eberhard, Andrew; Stacey, Andrew

    2011-12-01

    This article describes a qualitative study which was undertaken to improve the delivery methods and feedback opportunity in honours mathematics lectures which are delivered through Access Grid Rooms. Access Grid Rooms are facilities that provide two-way video and audio interactivity across multiple sites, with the inclusion of smart boards. The principal aim was to improve the student learning experience, given the new environment. The specific aspects of the course delivery that the study focused on included presentation of materials and provision of opportunities for interaction between the students and between students and lecturers. The practical considerations in the delivery of distance learning are well documented in the literature, and similar problems arise in the Access Grid Room environment; in particular, those of limited access to face-to-face interaction and the reduction in peer support. The nature of the Access Grid Room classes implies that students studying the same course can be physically situated in different cities, and possibly in different countries. When studying, it is important that students have opportunity to discuss new concepts with others; particularly their peers and their lecturer. The Access Grid Room environment also presents new challenges for the lecturer, who must learn new skills in the delivery of materials. The unique nature of Access Grid Room technology offers unprecedented opportunity for effective course delivery and positive outcomes for students, and was developed in response to a need to be able to interact with complex data, other students and the instructor, in real-time, at a distance and from multiple sites. This is a relatively new technology and as yet there has been little or no studies specifically addressing the use and misuse of the technology. The study found that the correct placement of cameras and the use of printed material and smart boards were all crucial to the student experience. In addition, the

  18. IFLA General Conference, 1985. International Association of Law Libraries (IALL) Round-Table on Access to Information in International Legal Research. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on international access to information pertaining to legal research, which were presented at the 1985 conference of the International Federation of Library Associations (IFLA) include: (1) "Materials of European Intergovernmental Organizations and Their Accessibility through Available Research Tools" (Irene Berkey, Northwestern University…

  19. HPV and the Ethics of CDC's Vaccination Requirements for Immigrants.

    PubMed

    Navin, Mark

    2015-06-01

    The United States may justifiably exclude unvaccinated aliens, perhaps even under the assumption of Open Borders, according to which people should generally be permitted to settle in countries of their choosing. Furthermore, there are good reasons to endorse the Centers for Disease Control and Prevention's (CDC's) current vaccination-related exclusion criteria, which were last revised in 2009. I frame my discussion around CDC's 2008 decision to permit immigrant girls and women to be excluded if they were not vaccinated against human papillomavirus (HPV)-a decision that was quickly reversed and that led to the 2009 revisions to CDC's vaccination-related immigrant exclusion criteria.

  20. Agrobacterium radiobacter and CDC group Ve-2 bacteremia.

    PubMed

    Blumberg, D A; Cherry, J D

    1989-01-01

    Agrobacterium radiobacter and CDC Group Ve-2 are rare human pathogens. The simultaneous infection with both of these bacteria in an immunocompromised host is reported. Review of the UCLA microbiology laboratory records revealed one additional case of A. radiobacter bacteremia and two additional cases of CDC Group Ve-2 bacteremia over a 3-year period. The clinical experience with these organisms is reviewed. Both organisms are opportunistic pathogens with a predilection for patients with foreign bodies in place. Although CDC Group Ve-2 bacteremia may respond to antibiotic therapy alone, the cure of A. radiobacter infections often requires foreign body removal.

  1. Success with ACCESS: Use of Community-Based Participatory Research for Implementation

    ERIC Educational Resources Information Center

    Eilola, Carolyn; Fishman, Kathryn; Greenburg, Arielle; Moore, Crystal Dea; Schrijver, Andrew; Totino, Jamin

    2011-01-01

    The Assessment of Campus Climate to Enhance Student Success survey (ACCESS) is a set of four questionnaires designed to elicit feedback from five campus constituencies including faculty, administration, staff, students with disabilities, and students without disabilities "to use in planning and garnering support for meaningful activities and…

  2. Overcoming Exclusion through Quality Schooling. Pathways to Access. Research Monograph No. 65

    ERIC Educational Resources Information Center

    Govinda, R.; Bandyopadhyay, Madhumita

    2011-01-01

    In the era of globalisation, provision of quality education is increasingly gaining importance across the world. Like elsewhere, it has already been realised in India that equal attention is needed simultaneously on access, equity and quality to achieve the goal of universalisation of elementary education. It has also been experienced that…

  3. Providing African-American Students Access to Science and Mathematics. Research Report #2.

    ERIC Educational Resources Information Center

    Johnson, Robert C.

    This review examines African American students' access to science and mathematics education, their status and achievement in these fields, factors influencing achievement, and strategies to address the current situation. African Americans are highly underrepresented in the scientific and technical fields. This situation should be corrected because…

  4. Restrictive Access to Books in School Library Media Centers in Georgia. Research Study.

    ERIC Educational Resources Information Center

    DuPree, Vi

    This study sought to determine the extent of restrictive access to books in Georgia school library media centers and to discover by whose authority and for what reason these books might be placed on restrictive shelves. Questionnaires were completed and received from a stratified random sampling of 119 media specialists in high schools, middle or…

  5. Mining Social Tagging Data for Enhanced Subject Access for Readers and Researchers

    ERIC Educational Resources Information Center

    Lawson, Karen G.

    2009-01-01

    Social tagging enables librarians to partner with users to provide enhanced subject access. This paper quantifies and compares LC subject headings from each of 31 different subject divisions with user tags from Amazon.com and LibraryThing assigned to the same titles. The intersection and integration of these schemas is described and evaluated.…

  6. 45 CFR 601.9 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) NATIONAL SCIENCE FOUNDATION CLASSIFICATION AND DECLASSIFICATION OF NATIONAL SECURITY INFORMATION § 601.9... access to classified information may be granted only as is essential to the accomplishment of lawful and... execute written agreements to safeguard the information and written consent to the Foundation's review...

  7. Child Labor, Income Shocks, and Access to Credit. Policy Research Working Paper.

    ERIC Educational Resources Information Center

    Beegle, Kathleen; Dehejia, Rajeev H.; Gatti, Roberta

    Although a growing theoretical literature points to credit constraints as an important source of inefficiently high child labor, little work has been done to assess its empirical relevance. This paper examines the direct effect of a transitory income shock on household child labor choices, as well as the extent to which access to credit helps…

  8. Enhancing Digital Access to Learning Materials for Canadians with Perceptual Disabilities: A Pilot Study. Research Report

    ERIC Educational Resources Information Center

    Lockerby, Christina; Breau, Rachel; Zuvela, Biljana

    2006-01-01

    By exploring the experiences of participants with DAISY (Digital Accessible Information System) Talking Books, the study reported in this article not only discovered how people who are blind, visually impaired, and/or print-disabled read DAISY books, but also identified participants' perceptions of DAISY as being particularly useful in their…

  9. Minority Group Equity at Delta College: Trends in Student Access and Affirmative Action Hiring. Research Note.

    ERIC Educational Resources Information Center

    Evans, John W.; Morris, Anita

    To provide a progress report on efforts to increase access to minority students and diversify the teaching and administrative ranks, a study was conducted at San Joaquin Delta College (SJDC), in California, of recent trends in minority student attendance and graduation rates and the ethnic composition of faculty and administrative staff. Results…

  10. Making Research Useful for CEO's and Trustees: Examples from Research on Faculty Salaries, Enrollment Projections, and Minority Access.

    ERIC Educational Resources Information Center

    Evans, John W.

    Drawing on four examples of institutional research undertaken at San Joaquin Delta College (SJDC), this paper offers six principles to help researchers make their work more relevant and to enable decision makers to utilize research more effectively. The research examples provide brief descriptions of the need for, methodology of, and findings of…

  11. Linking NASA Environmental Data with a National Public Health Cohort Study and a CDC On-Line System to Enhance Public Health Decision Making

    NASA Technical Reports Server (NTRS)

    Al-Hamdan, Mohammad; Crosson, William; Economou, Sigrid; Estes, Maurice, Jr.; Estes, Sue; Hemmings, Sarah; Kent, Shia; Puckett, Mark; Quattrochi, Dale; Wade, Gina; McClure, Leslie

    2012-01-01

    linkage of these data provides a useful addition to CDC WONDER, allowing public health researchers and policy makers to better include environmental exposure data in the context of other health data available in this online system. It also substantially expands public access to NASA data, making their use by a wide range of decision makers feasible.

  12. Open Access Centre at the Nature Research Centre: a facility for enhancement of scientific research, education and public outreach in Lithuania

    NASA Astrophysics Data System (ADS)

    Šerpenskienė, Silvija; Skridlaitė, Gražina

    2014-05-01

    Open Access Centre (OAC) was established in Vilnius, Lithuania in 2013 as a subdivision of the Nature Research Centre (NRC) operating on the principle of open access for both internal and external users. The OAC consists of 15 units, i.e. 15 NRC laboratories or their branches. Forty four sets of research equipment were purchased. The OAC cooperates with Lithuanian science and studies institutions, business sector and other governmental and public institutions. Investigations can be carried in the Geosciences, Biotaxonomy, Ecology and Molecular Research, and Ecotoxicology fields. Environmental radioactivity, radioecology, nuclear geophysics, microscopic and chemical composition of natural compounds (minerals, rocks etc.), paleomagnetic, magnetic and environmental investigations, as well as ground and water contamination by oil products and other organic environment polluting compounds, identification of fossils, rocks and minerals can be studied in the Georesearch field. Ecosystems and identification of plants, animals and microorganisms are main subjects of the Biotaxonomy, Ecology and Molecular Research field. The Ecotoxicologal Research deals with toxic and genotoxic effects of toxic substances and other sources of pollution on macro- and microorganisms and cell cultures. Open access is guaranteed by: (1) providing scientific research and experimental development services; (2) implementing joint business and science projects; (3) using facilities for the training of specialists of the highest qualifications; (4) providing properly qualified and technically trained users with opportunities to carry out their scientific research and/or experiments in the OAC laboratories by themselves. Services provided in the Open Access Centre can be received by both internal and external users: persons undertaking innovative economic activities, students of other educational institutions, interns, external teams of researchers engaged in scientific research activities, teachers

  13. Variation in low food access areas due to data source inaccuracies.

    PubMed

    Ma, Xiaoguang; Battersby, Sarah E; Bell, Bethany A; Hibbert, James D; Barnes, Timothy L; Liese, Angela D

    2013-12-01

    Several spatial measures of community food access identifying so called "food deserts" have been developed based on geospatial information and commercially-available, secondary data listings of food retail outlets. It is not known how data inaccuracies influence the designation of Census tracts as areas of low access. This study replicated the U.S. Department of Agriculture Economic Research Service (USDA ERS) food desert measure and the Centers for Disease Control and Prevention (CDC) non-healthier food retail tract measure in two secondary data sources (InfoUSA and Dun & Bradstreet) and reference data from an eight-county field census covering169 Census tracts in South Carolina. For the USDA ERS food deserts measure accuracy statistics for secondary data sources were 94% concordance, 50-65% sensitivity, and 60-64% positive predictive value (PPV). Based on the CDC non-healthier food retail tracts both secondary data demonstrated 88-91% concordance, 80-86% sensitivity and 78-82% PPV. While inaccuracies in secondary data sources used to identify low food access areas may be acceptable for large-scale surveillance, verification with field work is advisable for local community efforts aimed at identifying and improving food access.

  14. Variation in low food access areas due to data source inaccuracies

    PubMed Central

    Ma, Xiaoguang; Battersby, Sarah E.; Bell, Bethany A.; Hibbert, James D.; Barnes, Timothy L.; Liese, Angela D.

    2013-01-01

    Several spatial measures of community food access identifying so called “food deserts” have been developed based on geospatial information and commercially-available, secondary data listings of food retail outlets. It is not known how data inaccuracies influence the designation of Census tracts as areas of low access. This study replicated the U.S. Department of Agriculture Economic Research Service (USDA ERS) food desert measure and the Centers for Disease Control and Prevention (CDC) non-healthier food retail tract measure in two secondary data sources (InfoUSA and Dun & Bradstreet) and reference data from an eight-county field census covering169 Census tracts in South Carolina. For the USDA ERS food deserts measure accuracy statistics for secondary data sources were 94% concordance, 50–65% sensitivity, and 60–64% positive predictive value (PPV). Based on the CDC non-healthier food retail tracts both secondary data demonstrated 88–91% concordance, 80–86% sensitivity and 78–82% PPV. While inaccuracies in secondary data sources used to identify low food access areas may be acceptable for large-scale surveillance, verification with field work is advisable for local community efforts aimed at identifying and improving food access. PMID:24367136

  15. pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students

    ERIC Educational Resources Information Center

    Campbell, A. Malcolm; Eckdahl, Todd; Cronk, Brian; Andresen, Corinne; Frederick, Paul; Huckuntod, Samantha; Shinneman, Claire; Wacker, Annie; Yuan, Jason

    2014-01-01

    The "Vision and Change" report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area…

  16. Getting Past the Gatekeeper: Safeguarding and Access Issues in Researching HIV+ Children in Jamaica

    ERIC Educational Resources Information Center

    Miller, Paul; Kelly, Kemesha; Spawls, Nicola

    2013-01-01

    This article is derived from a recently completed research study on the "Schooling Experiences of HIV+ Children in Jamaica". It is written against the background of researching children generally, and also in the context of researching vulnerable children, specifically those who are HIV+. Research carries with it various notions of power and…

  17. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from...

  18. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the...

  19. 13 CFR 120.826 - Basic requirements for operating a CDC.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CDC. 120.826 Section 120.826 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.826 Basic requirements for operating a CDC. A CDC must operate in accordance with the following...

  20. 13 CFR 120.826 - Basic requirements for operating a CDC.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CDC. 120.826 Section 120.826 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.826 Basic requirements for operating a CDC. A CDC must operate in accordance with the following...

  1. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from...

  2. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the...

  3. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from...

  4. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small...

  5. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small...

  6. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the...

  7. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small...

  8. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the...

  9. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the...

  10. 13 CFR 120.826 - Basic requirements for operating a CDC.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CDC. 120.826 Section 120.826 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.826 Basic requirements for operating a CDC. A CDC must operate in accordance with the following...

  11. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small...

  12. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that...

  13. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the...

  14. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that...

  15. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from...

  16. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the...

  17. 13 CFR 120.857 - Voluntary transfer and surrender of CDC certification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of CDC certification. 120.857 Section 120.857 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Other Cdc Requirements § 120.857 Voluntary transfer and surrender of CDC certification. A CDC may not transfer its certification or withdraw from...

  18. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the...

  19. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that...

  20. 13 CFR 120.820 - CDC non-profit status and good standing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false CDC non-profit status and good... LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.820 CDC non-profit status and good standing. A CDC must be a non-profit corporation, except that...

  1. 13 CFR 120.810 - Applications for certification as a CDC.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... a CDC. 120.810 Section 120.810 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.810 Applications for certification as a CDC. (a) An applicant for certification as a CDC must apply to the...

  2. 13 CFR 120.827 - Other services a CDC may provide to small businesses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Other services a CDC may provide... ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Requirements for Cdc Certification and Operation § 120.827 Other services a CDC may provide to small businesses. A CDC may provide a small...

  3. 13 CFR 120.935 - Deposit from the Borrower that a CDC may require.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CDC may require. 120.935 Section 120.935 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Borrower that a CDC may require. At the time of application for a 504 loan, the CDC may require a deposit... application is denied. If the small business withdraws its application, the CDC may deduct from the...

  4. CDC Ends Zika Travel Advisory for Miami Neighborhood

    MedlinePlus

    ... medlineplus.gov/news/fullstory_161032.html CDC Ends Zika Travel Advisory for Miami Neighborhood Pregnant women still ... News) -- U.S. health officials on Monday lifted the Zika virus travel advisory that urged pregnant women to ...

  5. Sex Partner with No Zika Symptoms Transmits Virus: CDC

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_160643.html Sex Partner With No Zika Symptoms Transmits Virus: CDC ... with the virus in June after having condomless sex with a man who had been to the ...

  6. Southern States Lagging in Tough Smoking Bans, CDC Says

    MedlinePlus

    ... fullstory_159529.html Southern States Lagging in Tough Smoking Bans, CDC Says Only 6 in 10 Americans covered by state or local laws banning smoking in public places To use the sharing features ...

  7. Smoking Losing Its Cool with Kids, CDC Says

    MedlinePlus

    ... finds. The same can't be said of e-cigarettes. Fewer students reported trying cigarettes or cigars between ... still showing a worrisome level of interest in e-cigarettes. The CDC released a survey in June that ...

  8. CDC Panel Says FluMist Nasal Flu Vaccine Ineffective

    MedlinePlus

    ... 159535.html CDC Panel Says FluMist Nasal Flu Vaccine Ineffective Agency advisors say the product has lost ... without the easier, nasal spray form of flu vaccine next flu season, a panel of experts decided ...

  9. Smoking Rates Still High in Some Racial Groups, CDC Reports

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_160256.html Smoking Rates Still High in Some Racial Groups, CDC ... lot of progress in getting Americans to stop smoking, some groups still have high smoking rates, a ...

  10. Heart Surgery Devices May Have Been Contaminated: CDC

    MedlinePlus

    ... 161469.html Heart Surgery Devices May Have Been Contaminated: CDC Patients who experience night sweats, fever, weight ... used during open heart surgery may have been contaminated with bacteria that puts patients at risk for ...

  11. Carbide-derived carbon (CDC) linear actuator properties in combination with conducting polymers

    NASA Astrophysics Data System (ADS)

    Kiefer, Rudolf; Aydemir, Nihan; Torop, Janno; Kilmartin, Paul A.; Tamm, Tarmo; Kaasik, Friedrich; Kesküla, Arko; Travas-Sejdic, Jadranka; Aabloo, Alvo

    2014-03-01

    Carbide-derived Carbon (CDC) material is applied for super capacitors due to their nanoporous structure and their high charging/discharging capability. In this work we report for the first time CDC linear actuators and CDC combined with polypyrrole (CDC-PPy) in ECMD (Electrochemomechanical deformation) under isotonic (constant force) and isometric (constant length) measurements in aqueous electrolyte. CDC-PPy actuators showing nearly double strain under cyclic voltammetric and square wave potential measurements in comparison to CDC linear actuators. The new material is investigated by SEM (scanning electron microscopy) and EDX (energy dispersive X-ray analysis) to reveal how the conducting polymer layer and the CDC layer interfere together.

  12. [HIV-AIDS: ethics in healthcare, research, and access to treatments].

    PubMed

    Hirsch, Emmanuel

    2003-01-01

    Violence and gravity cannot be ignored when considering HIV and AIDS challenges. However, coping with this pandemic disease caused us to build up and experience new ways of solidarity that have transformed our views of medical care and public health. The few achievements of these years throw a new light on the figure of the ill person. They brought new references allowing a different understanding of the political stakes of public health. Partnership or even therapeutic alliance are now a framework to the understanding of respect, solidarity and equity. New viewpoints exist on the health care relationship. Our achievements show at first injustice in the access of treatments at the international level. They make clear our moral responsibilities toward every person that require a treatment. This idea should be emphasized when applied on the most vulnerable communities. The most urgent challenges that remain today are extreme precariousness situations, treatment access conditions, information, and quality of life. PMID:12942447

  13. Doa1 is a MAD adaptor for Cdc48

    PubMed Central

    Zhang, Ting

    2016-01-01

    Dislocation of polypeptides from the mitochondrial outer membrane by the p97/Cdc48–Ufd1–Npl4 adenosine triphosphatase complex is essential for mitochondria-associated degradation and Parkin-mediated mitophagy. In this issue, Wu et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510098) identify Doa1 as a pivotal adaptor that recruits substrates to Cdc48 for processing. PMID:27044894

  14. 75 FR 11889 - Request for Comments on Proposed NIH, AHRQ and CDC Process Change for Electronic Submission of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... HUMAN SERVICES Request for Comments on Proposed NIH, AHRQ and CDC Process Change for Electronic Submission of Grant Applications AGENCY: Department of Health and Human Services. ACTION: Process change. SUMMARY: The National Institutes of Health (NIH), the Agency for Healthcare Research and Quality...

  15. Role of AtCDC48 & the AtCDC48 Regulatory Protein Family, PUX, in Plant Cell Morphogenesis

    SciTech Connect

    Bednarek, Sebastian, Y.

    2009-11-08

    The long-term objective of this work is to understand the molecular events and mechanisms involved in secretory membrane trafficking and organelle biogenesis, which are crucial for normal plant growth and development. Our studies have suggested a vital role for the cytosolic chaperone Cdc48p/p97 during cytokinesis and cell expansion which are highly dependent upon secretory membrane trafficking. Localization studies have shown that the plant Cdc48p/p97, AtCDC48, and the Arabidopsis ortholog of the ER- and Golgi-associated SNARE, syntaxin 5, (referred to as SYP31) are targeted to the division plane during cytokinesis. In addition, AtCDC48 and SYP31 were shown to interact in vitro and in vivo. To characterize further the function of AtCDC48 and SYP31 we have utilized affinity chromatography and MALDI-MS to identify several plant-specific proteins that interact with SYP31 and/or modulate the activity of AtCDC48 including two UBX (i.e. ubiquitin-like) domain containing proteins, PUX1 and PUX2 (Proteins containing UBX domain). These proteins define a plant protein family consisting of 15 uncharacterized members that we postulate interact with AtCDC48. Biochemical studies have demonstrated that PUX2 is a novel membrane adapter for AtCDC48 that mediates AtCDC48/SYP31 interaction and is likely to control AtCDC48-dependent membrane fusion. In contrast, PUX1 negatively regulates AtCDC48 by inhibiting its ATPase activity and by promoting the disassembly of the active hexamer. These findings provide the first evidence that the assembly and disassembly of the CDC48/p97complex is actually a dynamic process. This new unexpected level of regulation for CDC48/p97 was demonstrated to be critical in vivo as pux1 loss-of-function mutants grow faster than wild-type plants. These studies suggest a role for AtCDC48 in plant cell cycle progression including cytokinesis and/or cell expansion. The proposed studies are designed to: 1) characterize further the localization and function of AtCDC

  16. CDC25A phosphatase controls meiosis I progression in mouse oocytes.

    PubMed

    Solc, Petr; Saskova, Adela; Baran, Vladimir; Kubelka, Michal; Schultz, Richard M; Motlik, Jan

    2008-05-01

    CDK1 is a pivotal regulator of resumption of meiosis and meiotic maturation of oocytes. CDC25A/B/C are dual-specificity phosphatases and activate cyclin-dependent kinases (CDKs). Although CDC25C is not essential for either mitotic or meiotic cell cycle regulation, CDC25B is essential for CDK1 activation during resumption of meiosis. Cdc25a -/- mice are embryonic lethal and therefore a role for CDC25A in meiosis is unknown. We report that activation of CDK1 results in a maturation-associated decrease in the amount of CDC25A protein, but not Cdc25a mRNA, such that little CDC25A is present by metaphase I. In addition, expression of exogenous CDC25A overcomes cAMP-mediated maintenance of meiotic arrest. Microinjection of Gfp-Cdc25a and Gpf-Cdc25b mRNAs constructs reveals that CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. Over-expressing GFP-CDC25A, which compensates for the normal maturation-associated decrease in CDC25A, blocks meiotic maturation at MI. This MI block is characterized by defects in chromosome congression and spindle formation and a transient reduction in both CDK1 and MAPK activities. Lastly, RNAi-mediated reduction of CDC25A results in fewer oocytes resuming meiosis and reaching MII. These data demonstrate that CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI-MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes.

  17. CDC25A phosphatase controls meiosis I progression in mouse oocytes

    PubMed Central

    Solc, Petr; Saskova, Adela; Baran, Vladimir; Kubelka, Michal; Schultz, Richard M.; Motlik, Jan

    2008-01-01

    CDK1 is a pivotal regulator of resumption of meiosis and meiotic maturation of oocytes. CDC25A/B/C are dual-specificity phosphatases and activate cyclin-dependent kinases (CDKs). Although CDC25C is not essential for either mitotic or meiotic cell cycle regulation, CDC25B is essential for CDK1 activation during resumption of meiosis. Cdc25a −/− mice are embryonic lethal and therefore a role for CDC25A in meiosis is unknown. We report that activation of CDK1 results in a maturation-associated decrease in the amount of CDC25A protein, but not Cdc25a mRNA, such that little CDC25A is present by metaphase I. In addition, expression of exogenous CDC25A overcomes cAMP-mediated maintenance of meiotic arrest. Microinjection of Gfp-Cdc25a and Gpf-Cdc25b mRNAs constructs reveals that CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. Over-expressing GFP-CDC25A, which compensates for the normal maturation-associated decrease in CDC25A, blocks meiotic maturation at MI. This MI block is characterized by defects in chromosome congression and spindle formation and a transient reduction in both CDK1 and MAPK activities. Last, RNAi-mediated reduction of CDC25A results in fewer oocytes resuming meiosis and reaching MII. These data demonstrate that CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI-MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes. PMID:18367163

  18. CDC Vital Signs: Prescription Painkiller Overdoses

    MedlinePlus

    ... including screening and monitoring for substance abuse and mental health problems. Use prescription drug monitoring programs to identify ... effective pain treatment. Working to improve access to mental health and substance abuse treatment through implementation of the ...

  19. CDC Vital Signs: Opioid Painkiller Prescribing

    MedlinePlus

    ... and guidance for decision making based on proven practices. Increasing access to mental health and substance abuse treatment through the Affordable ... that do not involve prescription painkillers. Follow best practices for ... health problems. Avoiding combinations of prescription painkillers and ...

  20. Ethics, Reflexivity and Access in Educational Research: Issues in Intergenerational Investigation

    ERIC Educational Resources Information Center

    Basit, Tehmina N.

    2013-01-01

    Educational researchers, like other academic investigators, are expected to carry out research in an ethical manner. This paper draws on the author's experience of conducting a research study related to social justice, which examines intergenerational dynamics and education amongst British Asian families. It discusses the importance of…

  1. From College Access to Completion: State and Federal Policy Levers. Research Brief

    ERIC Educational Resources Information Center

    Quay, Lisa

    2010-01-01

    The Warren Institute is a multidisciplinary, collaborative venture to produce research, research-based policy prescriptions, and curricular innovation on issues of racial and ethnic justice in California and the nation. The Civil Rights Research Roundtable on Education is an initiative of the Warren Institute that convenes an ongoing learning…

  2. Accessing and Using Public Educational Data Sources for School and Leadership Research. Implications from UCEA

    ERIC Educational Resources Information Center

    Baker, Bruce

    2008-01-01

    Much educational policy research can be conducted with existing data sources, either created for research purposes or for managing and maintaining information on public schooling systems. These often under-used resources offer rich research opportunities on the relationship between teacher and principal careers, school and district differences and…

  3. Ensuring the Integrity, Accessibility, and Stewardship of Research Data in the Digital Age

    ERIC Educational Resources Information Center

    National Academies Press, 2009

    2009-01-01

    As digital technologies are expanding the power and reach of research, they are also raising complex issues. These include complications in ensuring the validity of research data; standards that do not keep pace with the high rate of innovation; restrictions on data sharing that reduce the ability of researchers to verify results and build on…

  4. Health economics and outcomes research within drug development: challenges and opportunities for reimbursement and market access within biopharma research.

    PubMed

    van Nooten, Floortje; Holmstrom, Stefan; Green, Julia; Wiklund, Ingela; Odeyemi, Isaac A O; Wilcox, Teresa K

    2012-06-01

    Healthcare decision makers who determine funding for new medical technologies depend on manufacturers to provide evidence of the technology's efficacy, safety and cost-effectiveness. Constrained budgets and increasing reliance on formal health technology assessment (HTA) have created an abundance of external hurdles that manufacturers must navigate to ensure successful product commercialization. These demands have pushed pharmaceutical companies to adjust their internal structures to coordinate generation of appropriate evidence. In this article we summarize internal and external opportunities for manufacturers to establish a foundation of evidence for successful market access, starting in Phase I of development and continuing throughout the post-approval product lifecycle. PMID:22366662

  5. Health economics and outcomes research within drug development: challenges and opportunities for reimbursement and market access within biopharma research.

    PubMed

    van Nooten, Floortje; Holmstrom, Stefan; Green, Julia; Wiklund, Ingela; Odeyemi, Isaac A O; Wilcox, Teresa K

    2012-06-01

    Healthcare decision makers who determine funding for new medical technologies depend on manufacturers to provide evidence of the technology's efficacy, safety and cost-effectiveness. Constrained budgets and increasing reliance on formal health technology assessment (HTA) have created an abundance of external hurdles that manufacturers must navigate to ensure successful product commercialization. These demands have pushed pharmaceutical companies to adjust their internal structures to coordinate generation of appropriate evidence. In this article we summarize internal and external opportunities for manufacturers to establish a foundation of evidence for successful market access, starting in Phase I of development and continuing throughout the post-approval product lifecycle.

  6. Adventitious Arsenate Reductase Activity of the Catalytic Domain of the Human Cdc25B and Cdc25C Phosphatases†

    PubMed Central

    Bhattacharjee, Hiranmoy; Sheng, Ju; Ajees, A. Abdul; Mukhopadhyay, Rita; Rosen, Barry P.

    2013-01-01

    A number of eukaryotic enzymes that function as arsenate reductases are homologues of the catalytic domain of the human Cdc25 phosphatase. For example, the Leishmania major enzyme LmACR2 is both a phosphatase and an arsenate reductase, and its structure bears similarity to the structure of the catalytic domain of human Cdc25 phosphatase. These reductases contain an active site C-X5-R signature motif, where C is the catalytic cysteine, the five X residues form a phosphate binding loop, and R is a highly conserved arginine, which is also present in human Cdc25 phosphatases. We therefore investigated the possibility that the three human Cdc25 isoforms might have adventitious arsenate reductase activity. The sequences for the catalytic domains of Cdc25A, -B, and -C were cloned individually into a prokaryotic expression vector, and their gene products were purified from a bacterial host using nickel affinity chromatography. While each of the three Cdc25 catalytic domains exhibited phosphatase activity, arsenate reductase activity was observed only with Cdc25B and -C. These two enzymes reduced inorganic arsenate but not methylated pentavalent arsenicals. Alteration of either the cysteine and arginine residues of the Cys-X5-Arg motif led to the loss of both reductase and phosphatase activities. Our observations suggest that Cdc25B and -C may adventitiously reduce arsenate to the more toxic arsenite and may also provide a framework for identifying other human protein tyrosine phosphatases containing the active site Cys-X5-Arg loop that might moonlight as arsenate reductases. PMID:20025242

  7. Data Flow Infrastructure Initiative (DFII): Coupling Inventory Practices and Data collection Technology to Enhance Research Productivity and Information Access

    NASA Astrophysics Data System (ADS)

    Meyer, K.; Malin, R.; Rich, R. L.; Pierce, S. A.

    2011-12-01

    Shortening the cycle from data collection to research publications is a competitive advantage for researchers. Existing technologies for inventory systems such as UPC barcoding systems can be coupled with flexible mobile or handheld devices to advance efficiency, productivity, automation, and integrity in data flows, from data collection to sample processing to database management and analysis, and finally publication. At the University of Texas, the Data Flow Infrastructure Initiative (DFII) has introduced handheld devices with integrated barcode scanners as a mechanism to enhance research productivity and information access. These devices are established technology and provide a flexible but consistent platform for research data collection and data management. They are not in widespread use yet in the research community. Additional application benefits will accrue by using handheld devices to deliver data on demand in teaching applications. Introducing research scientists, graduate students, and the UT community to the merits and flexibility of these data collection technologies will provide avenues for innovation as well as improving efficiency. The objective of this project is to bring the technology and expertise with handheld systems to a diverse set of pilot projects and establish proficiency at The University of Texas at Austin necessary for widespread application. We have implemented a pilot project in three research labs covering the fields of microbial ecology, water resources decision support, and biogeochemistry to introduce these technologies. We used NautizX5 handheld devices that feature: barcode scanning, bluetooth, stylus, and keypad data inputs coupled with Pendragon Forms Software, a program that allows users to create custom data collection forms structured into an SQL or Access platform thus allowing concurrent data management, data collection and analysis in field and lab settings. Results include the elimination of most manual data entry

  8. Deployment of a Testbed in a Brazilian Research Network using IPv6 and Optical Access Technologies

    NASA Astrophysics Data System (ADS)

    Martins, Luciano; Ferramola Pozzuto, João; Olimpio Tognolli, João; Chaves, Niudomar Siqueira De A.; Reggiani, Atilio Eduardo; Hortêncio, Claudio Antonio

    2012-04-01

    This article presents the implementation of a testbed and the experimental results obtained with it on the Brazilian Experimental Network of the government-sponsored "GIGA Project." The use of IPv6 integrated to current and emerging optical architectures and technologies, such as dense wavelength division multiplexing and 10-gigabit Ethernet on the core and gigabit capable passive optical network and optical distribution network on access, were tested. These protocols, architectures, and optical technologies are promising and part of a brand new worldwide technological scenario that has being fairly adopted in the networks of enterprises and providers of the world.

  9. AstroCloud, a Cyber-Infrastructure for Astronomy Research: Data Access and Interoperability

    NASA Astrophysics Data System (ADS)

    Fan, D.; He, B.; Xiao, J.; Li, S.; Li, C.; Cui, C.; Yu, C.; Hong, Z.; Yin, S.; Wang, C.; Cao, Z.; Fan, Y.; Mi, L.; Wan, W.; Wang, J.

    2015-09-01

    Data access and interoperability module connects the observation proposals, data, virtual machines and software. According to the unique identifier of PI (principal investigator), an email address or an internal ID, data can be collected by PI's proposals, or by the search interfaces, e.g. conesearch. Files associated with the searched results could be easily transported to cloud storages, including the storage with virtual machines, or several commercial platforms like Dropbox. Benefitted from the standards of IVOA (International Observatories Alliance), VOTable formatted searching result could be sent to kinds of VO software. Latter endeavor will try to integrate more data and connect archives and some other astronomical resources.

  10. Data, Data Everywhere, but Access Remains a Big Issue for Researchers: A Review of Access Policies for Publicly-Funded Patient-Level Health Care Data in the United States

    PubMed Central

    Doshi, Jalpa A.; Hendrick, Franklin B.; Graff, Jennifer S.; Stuart, Bruce C.

    2016-01-01

    Introduction: High quality research regarding treatment effectiveness, quality, and value is critical for improving the U.S. health care system. Recognition of this has led federal and state officials to better leverage existing data sources such as medical claims and survey data, but access must be balanced with privacy concerns. Methods: We reviewed and catalogued data access policies for a selection of publicly-funded federal and state datasets to investigate how such policies may be promoting or limiting research activities. Results: We found significant variation in data access policies across federal agencies and across state agencies, including variation for multiple datasets available from the same agency. We also observed numerous indirect hurdles to use of data, including complex data use application procedures, high user fees, and prolonged wait times for data delivery. Conclusions: Policy makers and data owners should consider making changes to data access policies to maximize the utility and availability of these valuable resources. PMID:27141517

  11. Science, institutional archives and open access: an overview and a pilot survey on the Italian cancer research institutions

    PubMed Central

    2010-01-01

    Background The Open Archive Initiative (OAI) refers to a movement started around the '90s to guarantee free access to scientific information by removing the barriers to research results, especially those related to the ever increasing journal subscription prices. This new paradigm has reshaped the scholarly communication system and is closely connected to the build up of institutional repositories (IRs) conceived to the benefit of scientists and research bodies as a means to keep possession of their own literary production. The IRs are high-value tools which permit authors to gain visibility by enabling rapid access to scientific material (not only publications) thus increasing impact (citation rate) and permitting a multidimensional assessment of research findings. Methods A survey was conducted in March 2010 to mainly explore the managing system in use for archiving the research finding adopted by the Italian Scientific Institutes for Research, Hospitalization and Health Care (IRCCS) of the oncology area within the Italian National Health Service (Servizio Sanitario Nazionale, SSN). They were asked to respond to a questionnaire intended to collect data about institutional archives, metadata formats and posting of full-text documents. The enquiry concerned also the perceived role of the institutional repository DSpace ISS, built up by the Istituto Superiore di Sanità (ISS) and based on a XML scheme for encoding metadata. Such a repository aims at acting as a unique reference point for the biomedical information produced by the Italian research institutions. An in-depth analysis has also been performed on the collection of information material addressed to patients produced by the institutions surveyed. Results The survey respondents were 6 out of 9. The results reveal the use of different practices and standard among the institutions concerning: the type of documentation collected, the software adopted, the use and format of metadata and the conditions of

  12. 40 CFR 11.6 - Access by historical researchers and former Government officials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to historical researchers or to persons who formerly occupied policymaking positions to which they... policymaking position shall be limited to those papers which the former official originated, reviewed,...

  13. 40 CFR 11.6 - Access by historical researchers and former Government officials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to historical researchers or to persons who formerly occupied policymaking positions to which they... policymaking position shall be limited to those papers which the former official originated, reviewed,...

  14. 40 CFR 11.6 - Access by historical researchers and former Government officials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to historical researchers or to persons who formerly occupied policymaking positions to which they... policymaking position shall be limited to those papers which the former official originated, reviewed,...

  15. 40 CFR 11.6 - Access by historical researchers and former Government officials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to historical researchers or to persons who formerly occupied policymaking positions to which they... policymaking position shall be limited to those papers which the former official originated, reviewed,...

  16. 40 CFR 11.6 - Access by historical researchers and former Government officials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to historical researchers or to persons who formerly occupied policymaking positions to which they... policymaking position shall be limited to those papers which the former official originated, reviewed,...

  17. Discriminating Between Legitimate and Predatory Open Access Journals: Report from the International Federation for Emergency Medicine Research Committee

    PubMed Central

    Hansoti, Bhakti; Langdorf, Mark I.; Murphy, Linda S.

    2016-01-01

    Introduction Open access (OA) medical publishing is growing rapidly. While subscription-based publishing does not charge the author, OA does. This opens the door for “predatory” publishers who take authors’ money but provide no substantial peer review or indexing to truly disseminate research findings. Discriminating between predatory and legitimate OA publishers is difficult. Methods We searched a number of library indexing databases that were available to us through the University of California, Irvine Libraries for journals in the field of emergency medicine (EM). Using criteria from Jeffrey Beall, University of Colorado librarian and an expert on predatory publishing, and the Research Committee of the International Federation for EM, we categorized EM journals as legitimate or likely predatory. Results We identified 150 journal titles related to EM from all sources, 55 of which met our criteria for OA (37%, the rest subscription based). Of these 55, 25 (45%) were likely to be predatory. We present lists of clearly legitimate OA journals, and, conversely, likely predatory ones. We present criteria a researcher can use to discriminate between the two. We present the indexing profiles of legitimate EM OA journals, to inform the researcher about degree of dissemination of research findings by journal. Conclusion OA journals are proliferating rapidly. About half in EM are legitimate. The rest take substantial money from unsuspecting, usually junior, researchers and provide no value for true dissemination of findings. Researchers should be educated and aware of scam journals. PMID:27625710

  18. Discriminating Between Legitimate and Predatory Open Access Journals: Report from the International Federation for Emergency Medicine Research Committee

    PubMed Central

    Hansoti, Bhakti; Langdorf, Mark I.; Murphy, Linda S.

    2016-01-01

    Introduction Open access (OA) medical publishing is growing rapidly. While subscription-based publishing does not charge the author, OA does. This opens the door for “predatory” publishers who take authors’ money but provide no substantial peer review or indexing to truly disseminate research findings. Discriminating between predatory and legitimate OA publishers is difficult. Methods We searched a number of library indexing databases that were available to us through the University of California, Irvine Libraries for journals in the field of emergency medicine (EM). Using criteria from Jeffrey Beall, University of Colorado librarian and an expert on predatory publishing, and the Research Committee of the International Federation for EM, we categorized EM journals as legitimate or likely predatory. Results We identified 150 journal titles related to EM from all sources, 55 of which met our criteria for OA (37%, the rest subscription based). Of these 55, 25 (45%) were likely to be predatory. We present lists of clearly legitimate OA journals, and, conversely, likely predatory ones. We present criteria a researcher can use to discriminate between the two. We present the indexing profiles of legitimate EM OA journals, to inform the researcher about degree of dissemination of research findings by journal. Conclusion OA journals are proliferating rapidly. About half in EM are legitimate. The rest take substantial money from unsuspecting, usually junior, researchers and provide no value for true dissemination of findings. Researchers should be educated and aware of scam journals.

  19. CDC: better needlestick reporting required. Centers for Disease Control and Prevention.

    PubMed

    1997-03-01

    A recent study of percutaneous injuries from phlebotomy devices showed that only about half of all injuries were reported through the hospital surveillance system. In light of the success of post-exposure prophylaxis in reducing occupational HIV transmission, the Centers for Disease Control and Prevention (CDC) has recommended that health care facilities work to improve reporting. The year-long CDC study of health-care professionals revealed that on average 54 percent of needlestick injuries were reported, though reporting rates varied by occupation. Janine Jagger, director of the International Health Care Worker Safety Research and Resource Center, says some workers fail to report injuries because they do not consider a needlestick a high-risk event. Others, she notes, are concerned about the potential problems associated with contracting a bloodborne pathogen. The CDC, which recently issued recommendations for post-exposure prophylaxis, hopes that reports confirming the benefit of treatment will improve the reporting of accidents. Setting up a 24-hour hotline for employees is one way to improve reporting by making it convenient and confidential.

  20. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR).

    PubMed

    Eysenbach, Gunther

    2010-01-01

    Peer-reviewed journals remain important vehicles for knowledge transfer and dissemination in health informatics, yet, their format, processes and business models are changing only slowly. Up to the end of last century, it was common for individual researchers and scientific organizations to leave the business of knowledge transfer to professional publishers, signing away their rights to the works in the process, which in turn impeded wider dissemination. Traditional medical informatics journals are poorly cited and the visibility and uptake of articles beyond the medical informatics community remain limited. In 1999, the Journal of Medical Internet Research (JMIR; http://www.jmir.org) was launched, featuring several innovations including 1) ownership and copyright retained by the authors, 2) electronic-only, "lean" non-for-profit publishing, 3) openly accessible articles with a reversed business model (author pays instead of reader pays), 4) technological innovations such as automatic XML tagging and reference checking, on-the-fly PDF generation from XML, etc., enabling wide distribution in various bibliographic and full-text databases. In the past 10 years, despite limited resources, the journal has emerged as a leading journal in health informatics, and is presently ranked the top journal in the medical informatics and health services research categories by impact factor. The paper summarizes some of the features of the Journal, and uses bibliometric and access data to compare the influence of the Journal on the discipline of medical informatics and other disciplines. While traditional medical informatics journals are primarily cited by other Medical Informatics journals (33%-46% of citations), JMIR papers are to a more often cited by "end-users" (policy, public health, clinical journals), which may be partly attributable to the "open access advantage". PMID:20841900

  1. [Current modalities and concepts on access and use of biospecimen samples and associated data for research from human biobanks].

    PubMed

    Siddiqui, Roman; Semler, Sebastian Claudius

    2016-03-01

    It is accepted worldwide that biospecimen and data sharing (BDS) play an essential role for the future of medical research to improve diagnostics and prognostics, e.g. by validated biomarkers. BDS is also pivotal to the development of new therapeutic treatments and for the improvement of population health. Human biobanks can generate an added value to this need by providing biospecimens and/or associated data to researchers. An inspection of several examples of epidemiological as well as clinical/disease-oriented biobanks in Germany shows that best practice procedures (BPP) that are internationally agreed on are being installed for biospecimen and/or data access. In general, fair access is aimed at requiring a written application by the requesting scientist, which is then peer-reviewed for scientific and ethical validity by the Biobank. Applied BPP take into account (i) patient education/agreement according to the informed consent model, (ii) privacy protection, (iii) intellectual property rights, the (iv) notification obligation of health-related findings (including incidental findings), the (v) use of material (MTA) and data transfer agreements (DTA) for mutual legal security, the avoidance of conflicts of interests, as well as for cost recovery/fee for service as a basis for sustainability of the biobank. BPP are rooted in the self-regulation efforts of life sciences and are supported by parent ethics committees in Germany. Central biobank registries displaying aggregated information on biospecimens stored and the research foci constitute an important tool to make biobanks that are scattered across the country visible to each other, and, can thus promote access to hitherto unknown biospecimen and data resources. PMID:26809822

  2. 10 years experience with pioneering open access publishing in health informatics: the Journal of Medical Internet Research (JMIR).

    PubMed

    Eysenbach, Gunther

    2010-01-01

    Peer-reviewed journals remain important vehicles for knowledge transfer and dissemination in health informatics, yet, their format, processes and business models are changing only slowly. Up to the end of last century, it was common for individual researchers and scientific organizations to leave the business of knowledge transfer to professional publishers, signing away their rights to the works in the process, which in turn impeded wider dissemination. Traditional medical informatics journals are poorly cited and the visibility and uptake of articles beyond the medical informatics community remain limited. In 1999, the Journal of Medical Internet Research (JMIR; http://www.jmir.org) was launched, featuring several innovations including 1) ownership and copyright retained by the authors, 2) electronic-only, "lean" non-for-profit publishing, 3) openly accessible articles with a reversed business model (author pays instead of reader pays), 4) technological innovations such as automatic XML tagging and reference checking, on-the-fly PDF generation from XML, etc., enabling wide distribution in various bibliographic and full-text databases. In the past 10 years, despite limited resources, the journal has emerged as a leading journal in health informatics, and is presently ranked the top journal in the medical informatics and health services research categories by impact factor. The paper summarizes some of the features of the Journal, and uses bibliometric and access data to compare the influence of the Journal on the discipline of medical informatics and other disciplines. While traditional medical informatics journals are primarily cited by other Medical Informatics journals (33%-46% of citations), JMIR papers are to a more often cited by "end-users" (policy, public health, clinical journals), which may be partly attributable to the "open access advantage".

  3. Research and Practice in K-12 Online Learning: A Review of Open Access Literature

    ERIC Educational Resources Information Center

    Cavanaugh, Cathy S.; Barbour, Michael K.; Clark, Tom

    2009-01-01

    The literature related to online learning programs for K-12 students dates to the mid-1990s and builds upon a century of research and practice from K-12 distance education. While K-12 online learning programs have evolved and grown over the past decade, the amount of published research on virtual schooling practice and policy is limited. The…

  4. Accessible Research Experiences: A New Paradigm for In-Lab Chemical Education

    ERIC Educational Resources Information Center

    Baum, Marc M.; Krider, Elizabeth S.; Moss, John A.

    2006-01-01

    The preliminary efforts to engage students in the physical sciences through research projects in environmental chemistry are described. The successful involvement of two demographics, community college (CC) students and female students in cutting-edge chemistry research suggests that recruiting methods were effective and the feedback from…

  5. A Review of Vocational Research in the UK 2002-2006: Measurement and Accessibility Issues

    ERIC Educational Resources Information Center

    Johnson, Martin

    2006-01-01

    The UK vocational assessment landscape is changing and research has a key role in helping to identify trends and anticipate emerging issues and challenges. This review collates the messages from recently published research about specific issues that have been found to affect the measurement of vocational learning. It also highlights issues that…

  6. The Case for Public Access to Federally Funded Research Data. Policy Analysis.

    ERIC Educational Resources Information Center

    Gough, Michael; Milloy, Steven

    This study examines the importance of public review of federally funded scientific research by looking at several case studies. It shows that independent, nongovernmental review of federal scientific research has had a major positive effect on knowledge in many areas. The study focuses on: the Environmental Protection Agency and airborne asbestos;…

  7. Accessible Genetics Research Ethics Education (AGREE): A Web-Based Program for IRBs and Investigators

    SciTech Connect

    Sugarman, Jeremy; Lee, Linda

    2006-03-31

    The primary objective of this project was to design and evaluate a series of web-based educational modules on genetics research ethics for members of Institutional Review Boards and investigators to facilitate the development and oversight of important research that is sensitive to the relevant ethical, legal and social issues. After a needs assessment was completed in March of 2003, five online educational modules on the ethics of research in genetics were developed, tested, and made available through a host website for AGREE: http://agree.mc.duke.edu/index.html. The 5 modules are: (1) Ethics and Genetics Research in Populations; (2) Ethics in Behavioral Genetics Research; (3) Ethical Issues in Research on Gene-Environment Interactions; (4) Ethical Issues in Reproductive Genetics Research; and (5) Ethical Issues in Diagnostic and Therapeutic Research. The development process adopted a tested approach used at Duke University School of Medicine in providing education for researchers and IRB members, supplementing it with expert input and a rigorous evaluation. The host website also included a description of the AGREE; short bios on the AGREE Investigators and Expert Advisory Panel; streaming media of selected presentations from a conference, Working at the Frontiers of Law and Science: Applications of the Human Genome held October 2-3, 2003, at the University of North Carolina at Chapel Hill; and links to online resources in genomics, research ethics, ethics in genomics research, and related organizations. The web site was active beginning with the posting of the first module and was maintained throughout the project period. We have also secured agreement to keep the site active an additional year beyond the project period. AGREE met its primary objective of creating web-based educational modules related to the ethical issues in genetics research. The modules have been disseminated widely. While it is clearly easier to judge the quality of the educational experience

  8. "Big data" and "open data": What kind of access should researchers enjoy?

    PubMed

    Chatellier, Gilles; Varlet, Vincent; Blachier-Poisson, Corinne

    2016-02-01

    The healthcare sector is currently facing a new paradigm, the explosion of "big data". Coupled with advances in computer technology, the field of "big data" appears promising, allowing us to better understand the natural history of diseases, to follow-up new technologies (devices, drugs) implementation and to participate in precision medicine, etc. Data sources are multiple (medical and administrative data, electronic medical records, data from rapidly developing technologies such as DNA sequencing, connected devices, etc.) and heterogeneous while their use requires complex methods for accurate analysis. Moreover, faced with this new paradigm, we must determine who could (or should) have access to which data, how to combine collective interest and protection of personal data and how to finance in the long-term both operating costs and databases interrogation. This article analyses the opportunities and challenges related to the use of open and/or "big data", from the viewpoint of pharmacologists and representatives of the pharmaceutical and medical device industry.

  9. Based on asynchronous communication protocol of geographic space information service access mechanism research

    NASA Astrophysics Data System (ADS)

    Chen, G.; Zhao, J.; Gu, M.; Li, D.

    2014-04-01

    At present, the traditional way of accessing to classified network in geographic spatial information services is using network gatekeeper and firewall etc. to ensure public and classified network communications links. However, the physical isolation between classified network and public network is crossed, which is bound to cause classified network potential security hazard. In Yunnan province space Land dynamic monitoring integration project, it proposed the point to point text message communication protocol and asynchronous transmission mechanism. Using geo-spatial information encryption processing and data compression processing method, it reduced the risk of data sensitivity and monitored, namely to ensure data security, which realized geographic spatial information services data communication effectively between classified network and public network in the rigid field conditions.

  10. The dual specificity phosphatase Cdc14B bundles and stabilizes microtubules

    SciTech Connect

    Plumley, Hyekyung; Liu, Yie; Gomez, Marla V; Wang, Yisong

    2005-01-01

    The Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle. However, little is known about the function of mammalian CDC14B family members. Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated. CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its catalytic activity. Basic amino acid residues within the nucleolar targeting domain are important for both retaining CDC14B in the nucleolus and preventing microtubule bundling. Overexpression of CDC14B resulted in the formation of cytoplasmic CDC14B and microtubule bundles in interphase cells. These microtubule bundles were resistant to microtubule depolymerization reagents and enriched in acetylated -tubulin. Expression of cytoplasmic forms of CDC14B impaired microtubule nucleation from the microtubule organization center. CDC14B is thus a novel microtubule-bundling and -stabilizing protein, whose regulated subcellular localization may help modulate spindle and microtubule dynamics in mitosis.

  11. American Meteorological Society (AMS) - The Modern Era Retrospective-Analysis for Research and Applications (MERRA) Data and Accessibility

    NASA Technical Reports Server (NTRS)

    daSilva, Arlindo

    2009-01-01

    The AM Short Course on The Modern Era Retrospective-analysis for Research and Applications (MERRA) data and accessibility will be held on January 11, 2009 preceding the 89th Annual Meeting in Phoenix, Arizona. Preliminary programs, registration, hotel, and general information will be posted on the AMS Web site in mid-September 2008. Retrospective-analyses (or reanalyses) have been established as an important tool in weather and climate research over the last decade. As computer power increases, the data assimilation and modeling systems improve and become more advanced, the input data quality increases and so reanalyses become more reliable. In 2008, NASA Global Modeling and Assimilation Office began producing a new reanalysis called the Modem Era Retrospective-analysis for Research and Applications (MERRA). The initial data from the reanalysis has been made available to the community and should be complete through 30 years (1979-present) by Fall of 2009. MERRA has taken advantage of the advancement of computing resources to provide users more data than previously available. The native spatial resolution is nominally 1/2 degrees and the surface two dimensional data are one hourly frequency. In addition to the meteorological analysis data, complete mass, energy and momentum budget data and also stratospheric data are provided. The eventual data holdings will exceed 150Tb. In order to facilitate user accessibility to the data, it will be stored in online hard drives (not tape storage) and available through several portals. Subsetting tools will also be available to allow users to tailor their data requests. The goals of this short course are to provide hands on users of reanalyses instruction on MERRA systems and also interactive experience with the online data and access tools. The course is intended for students and research scientists who will be actively interested in accessing and applying MERRA data in their weather, climate or applications work. The course has

  12. The Cdc48 machine in endoplasmic reticulum associated protein degradation.

    PubMed

    Wolf, Dieter H; Stolz, Alexandra

    2012-01-01

    The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine in all eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold and pull proteins against physical forces, which make up a protein's structure and hold it in place. From the many cellular processes, Cdc48 is involved in, its function in endoplasmic reticulum associated protein degradation (ERAD) is understood best. This quality control process for proteins of the secretory pathway scans protein folding and discovers misfolded proteins in the endoplasmic reticulum (ER), the organelle, destined for folding of these proteins and their further delivery to their site of action. Misfolded lumenal and membrane proteins of the ER are detected by chaperones and lectins and retro-translocated out of the ER for degradation. Here the Cdc48 machinery, recruited to the ER membrane, takes over. After polyubiquitylation of the protein substrate, Cdc48 together with its dimeric co-factor complex Ufd1-Npl4 pulls the misfolded protein out and away from the ER membrane and delivers it to down-stream components for degradation by a cytosolic proteinase machine, the proteasome. The known details of the Cdc48-Ufd1-Npl4 motor complex triggered process are subject of this review article. PMID:21945179

  13. Whillans Ice Stream Subglacial Access Research Drilling (WISSARD): Integrative Study of Marine Ice Sheet Stability and Subglacial Life Habitats (Invited)

    NASA Astrophysics Data System (ADS)

    Tulaczyk, S. M.; Anandakrishnan, S.; Behar, A. E.; Christner, B. C.; Fisher, A. T.; Fricker, H. A.; Holland, D. M.; Jacobel, R. W.; Mikucki, J.; Mitchell, A. C.; Powell, R. D.; Priscu, J. C.; Scherer, R. P.; Severinghaus, J. P.

    2009-12-01

    The WISSARD project is a large, NSF-funded, interdisciplinary initiative focused on scientific drilling, exploration, and investigation of Antarctic subglacial aquatic environments. The project consists of three interrelated components: (1) LISSARD - Lake and Ice Stream Subglacial Access Research Drilling, (2) RAGES - Robotic Access to Grounding-zones for Exploration and Science, and (3) GBASE - GeomicroBiology of Antarctic Subglacial Environments). A number of previous studies in West Antarctica highlighted the importance of understanding ice sheet interactions with water, either at the basal boundary where ice streams come in contact with active subglacial hydrologic and geological systems or at the marine margin where the ice sheet is exposed to forcing from the global ocean and sedimentation. Recent biological investigations of Antarctic subglacial environments show that they provide a significant habitat for life and source of bacterial carbon in a setting that was previously thought to be inhospitable. Subglacial microbial ecosystems also enhance biogeochemical weathering, mobilizing elements from long term geological storage. The overarching scientific objective of WISSARD is to examine the subglacial hydrological system of West Antarctica in glaciological, geological, microbiological, geochemical, and oceanographic contexts. Direct sampling will yield seminal information on these systems and test the overarching hypothesis that active hydrological systems connect various subglacial environments and exert major control on ice sheet dynamics, subglacial sediment transfer, geochemistry, metabolic and phylogenetic diversity, and biogeochemical transformations and geological records of ice sheet history. Technological advances during WISSARD will provide the US-science community with a capability to access and study sub-ice sheet environments. Developing this technological infrastructure will benefit the broader science community and it will be available for

  14. Strategic Planning for a Data-Driven, Shared-Access Research Enterprise: Virginia Tech Research Data Assessment and Landscape Study

    ERIC Educational Resources Information Center

    Shen, Yi

    2016-01-01

    The data landscape study at Virginia Tech addresses the changing modes of faculty scholarship and supports the development of a user-centric data infrastructure, management, and curation system. The study investigates faculty researchers' current practices in organizing, describing, and preserving data and the emerging needs for services and…

  15. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation

    SciTech Connect

    Ninomiya-Tsuji, Jun ); Nomoto, Satoshi; Matsumoto, Kunihiro ); Yasuda, Hideyo ); Reed, S.I. )

    1991-10-15

    The authors have cloned two different human cDNAs that can complement cdc28 mutations of budding yeast Saccharomyces cerevisiae. One corresponds to a gene encoding human p34{sup CDC2} kinase, and the other to a gene (CDK2; cell division kinase) that has not been characterized previously. The CDK2 protein is highly homologous to p34{sup CDC2} kinase and more significantly is homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The human CDC2 and CDK2 genes were both able to complement the inviability of a null allele of S. cerevisiae CDC28. This result indicates that the CDK2 protein has a biological activity closely related to the CDC28 and p34{sup CDC2} kinases. However, CDK2 was unable to complement cdc2 mutants in fission yeast Schizosaccharomyces pombe under the condition where the human CDC2 gene could complement them. CDK2 mRNA appeared late in G{sub 1} or in early S phase, slightly before CDC2 mRNA, after growth stimulation in normal human fibroblast cells. These results suggest that in human cells, two different CDC2-like kinases may regulate the cell cycle at distinct stages.

  16. "Big data" and "open data": What kind of access should researchers enjoy?

    PubMed

    Chatellier, Gilles; Varlet, Vincent; Blachier-Poisson, Corinne

    2016-02-01

    The healthcare sector is currently facing a new paradigm, the explosion of "big data". Coupled with advances in computer technology, the field of "big data" appears promising, allowing us to better understand the natural history of diseases, to follow-up new technologies (devices, drugs) implementation and to participate in precision medicine, etc. Data sources are multiple (medical and administrative data, electronic medical records, data from rapidly developing technologies such as DNA sequencing, connected devices, etc.) and heterogeneous while their use requires complex methods for accurate analysis. Moreover, faced with this new paradigm, we must determine who could (or should) have access to which data, how to combine collective interest and protection of personal data and how to finance in the long-term both operating costs and databases interrogation. This article analyses the opportunities and challenges related to the use of open and/or "big data", from the viewpoint of pharmacologists and representatives of the pharmaceutical and medical device industry. PMID:27080635

  17. SPAM: A Canned Internet-Accessible Database of Interest to Solar Flare Researchers

    NASA Astrophysics Data System (ADS)

    Canfield, R. C.; Hudson, H. S.; Kiernan, E.; Metcalf, T. R.; Wulser, J.-P.

    1992-05-01

    We have established a searchable database, called SPAM (Spectroscopy and Polarimetry at Mees), which contains logs of observations made at Mees Solar Observatory (Haleakala, Maui). Of more general interest, the database also includes the Events List and Region Report from the Space Environment Laboratory (Boulder). Logs from YOHKOH are currently being added. Hence, SPAM can be used to determine, for example, whether Mees has vector magnetograms of a certain NOAA AR or whether YOHKOH has certain types of observations in specified time ranges. As well, it can be used to search the SEL database for flares with selected attributes. Included logs (and searchable attributes, in addition to date, day of year, and time) are: Mees Solar Observatory Log (instrument, NOAA AR, data type, observing setup), SEL Event List (NOAA AR, X-ray Class), SEL Region Report (NOAA AR), YOHKOH Orbit Summary, YOHKOH SXT Quiet Mode PFI Observations (latitude, longitude, X-ray and optical image size), YOHKOH Flare Observations (latitude, longitude, specific channel counts or ratios). SPAM runs on a Sun workstation at Mees Solar Observatory, and is available over Internet. Simply access (e.g., telnet) koa.ifa.hawaii.edu (128.171.167.1) from any vt100, Sun, or xterm emulator. Log on as spam (lower case); there is no password. New users are asked to read release notes and hints.

  18. US-Finland Planning Visit: Cooperative Research and Education Activities in Integrated Access Networks

    NASA Astrophysics Data System (ADS)

    Maclin, Arlene; University of Arizona-CIAN Collaboration; Aalto University in Finland Collaboration

    2011-03-01

    This planning grant visit sponsored by the NSF Office of International Science and Engineering occurred from October 3-10, 2010. The Dean of the School of Computer, Mathematical and Natural Sciences from Morgan State University (MSU), the PI and a faculty member from engineering at MSU along with a faculty member from the University of Arizona and two advanced level graduate students from the NSF-funded Center for Integrated Access Networks participated in this visit. The topic of novel low dimensional nano-materials was determined to be one possible area for future collaboration. As a result of this visit, a Materials World Network proposal has been submitted to the NSF involving MSU and CIAN in the US and Aalto University in Finland. A companion proposal on novel low dimensional nano- materials has also been submitted to the Academy of Finland. Another anticipated outcome of this collaboration of MSU with Aalto University and CIAN expands the outreach and diversity component to MSU, an institution serving largely an underrepresented minority student. Sponsor for this work was NSF # 1042309.

  19. Creating collaboration opportunities for marine research across the Arctic: The SEARCH-ACCESS partnership and an emerging sea ice prediction research network

    NASA Astrophysics Data System (ADS)

    Eicken, H.; Bitz, C. M.; Gascard, J.; Kaminski, T.; Karcher, M. J.; Kauker, F.; Overland, J. E.; Stroeve, J. C.; Wiggins, H. V.

    2013-12-01

    Rapid Arctic environmental and socio-economic change presents major challenges and opportunities to Arctic residents, government agencies and the private sector. The Arctic Ocean and its ice cover, in particular, are in the midst of transformative change, ranging from declines in sea-ice thickness and summer ice extent to threats to coastal communities and increases in maritime traffic and offshore resource development. The US interagency Study of Environmental Arctic Change (SEARCH) and the European Arctic Climate Change, Economy and Society (ACCESS) project are addressing both scientific research needs and stakeholder information priorities to improve understanding and responses to Arctic change. Capacity building, coordination and integration of activities at the international level and across sectors and stakeholder groups are major challenges that have to be met. ACCESS and SEARCH build on long-standing collaborations with a focus on environmental change in the Arctic ocean-ice-atmosphere system and the most pressing research needs to inform marine policy, resource management and threats to Arctic coastal communities. To illustrate the approach, key results and major conclusions from this international coordination and collaboration effort, we focus on a nascent sea-ice prediction research network. This activity builds on the Arctic Sea Ice Outlook that was initiated by SEARCH and the European DAMOCLES project (a precursor to ACCESS) and has now grown into an international community of practice that synthesizes, evaluates and discusses sea-ice predictions on seasonal to interannual scales. Key goals of the effort which is now entering into a new phase include the comparative evaluation of different prediction approaches, including the combination of different techniques, the compilation of reference datasets and model output, guidance on the design and implementation of observing system efforts to improve predictions and information transfer into private

  20. 32 CFR 2400.26 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... be granted only if the Director, Office of Science and Technology Policy: (1) Determines in writing... Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND... serving as a presidential appointee; and (4) Has received a written agreement from the researcher...

  1. 34 CFR 98.3 - Access to instructional material used in a research or experimentation program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... experimentation program. 98.3 Section 98.3 Education Office of the Secretary, Department of Education STUDENT... research or experimentation program. (a) All instructional material—including teachers' manuals, films, tapes, or other supplementary instructional material—which will be used in connection with any...

  2. 32 CFR 2400.26 - Access by historical researchers and former Presidential appointees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND... who: (1) Are engaged in historical research projects, or (2) Previously have occupied policy-making... be granted only if the Director, Office of Science and Technology Policy: (1) Determines in...

  3. Digital Resources for Research: A Review of Access and Use in African Universities

    ERIC Educational Resources Information Center

    Harle, Jonathan

    2009-01-01

    Good libraries are a critical part of any university's research and teaching, whether in physical or digital form. But, as numerous accounts have documented, many African libraries have struggled to maintain good collections in the face of falling budgets, rising purchasing costs, and expanding student numbers. This paper draws on a literature…

  4. Honest broker protocol streamlines research access to data while safeguarding patient privacy.

    PubMed

    Silvey, Scott A; Silvey, Scott Andrew; Schulte, Janet; Smaltz, Detlev H; Smaltz, Detlev Herb; Kamal, Jyoti

    2008-11-06

    At Ohio State University Medical Center, The Honest Broker Protocol provides a streamlined mechanism whereby investigators can obtain de-identified clinical data for non-FDA research without having to invest the significant time and effort necessary to craft a formalized protocol for IRB approval.

  5. A Theoretical and Empirical Review of the Death-Thought Accessibility Concept in Terror Management Research

    ERIC Educational Resources Information Center

    Hayes, Joseph; Schimel, Jeff; Arndt, Jamie; Faucher, Erik H.

    2010-01-01

    Terror management theory (TMT) highlights the motivational impact of thoughts of death in various aspects of everyday life. Since its inception in 1986, research on TMT has undergone a slight but significant shift from an almost exclusive focus on the manipulation of thoughts of death to a marked increase in studies that measure the accessibility…

  6. Universities' Access to Research Funds: Do Institutional Features and Strategies Matter?

    ERIC Educational Resources Information Center

    Rossi, Federica

    2009-01-01

    Competitively allocated research funds, from both public and private sources, constitute an increasing share of university revenues. The article investigates empirically, using data on the Italian university system, whether structural and strategic features of universities--such as size, age and especially the importance that they assign to their…

  7. Integrating Access to Arctic Environmental Change and Human Health Research for the International Polar Year and Beyond

    NASA Astrophysics Data System (ADS)

    Garrett, C. L.

    2006-12-01

    Each day, people in the communities of the Arctic face challenges to their health and well-being from changing climatic and environmental conditions and increasing levels of pollution to emerging infectious diseases. For this reason, it is critical that Arctic researchers and residents have access to timely, accurate, and relevant information addressing their unique concerns. To meet this need, the National Library of Medicine (NLM) and the University of Alaska Anchorage (UAA) have developed the Arctic Health website, www.arctichealth.org. The website provides an easy-to-use one-stop shop for information on the diverse health-related aspects of the Arctic region. It is organized around relevant topics, including climate change and environmental health, traditional healing and telehealth/telemedicine. The Arctic Health website provides links to the most reliable resources available from local, state, and international agencies, universities, and professional organizations. Two major goals of the site are to create a comprehensive, accessible repository for various media and a listing of research projects, past and present that relate to climate change and human health in the Arctic. To increase the site's relevance, the project has established and continues to create collaborations with researchers, communities, and other organizations to supply publications not available elsewhere, including gray literature, streaming video of traditional healers, and oral histories. These collaborations will also help ensure a database with a comprehensive list of research projects being done in the Arctic, from the international to the local level. Finding ways to negotiate the legal, cultural and national concerns of data sharing are a continuing job for the management team. All of this helps to create a system that will eventually track and ensure that data and reports from the research database translate to the publications database. As part of these efforts, the site is

  8. A case study of the Secure Anonymous Information Linkage (SAIL) Gateway: a privacy-protecting remote access system for health-related research and evaluation.

    PubMed

    Jones, Kerina H; Ford, David V; Jones, Chris; Dsilva, Rohan; Thompson, Simon; Brooks, Caroline J; Heaven, Martin L; Thayer, Daniel S; McNerney, Cynthia L; Lyons, Ronan A

    2014-08-01

    With the current expansion of data linkage research, the challenge is to find the balance between preserving the privacy of person-level data whilst making these data accessible for use to their full potential. We describe a privacy-protecting safe haven and secure remote access system, referred to as the Secure Anonymised Information Linkage (SAIL) Gateway. The Gateway provides data users with a familiar Windows interface and their usual toolsets to access approved anonymously-linked datasets for research and evaluation. We outline the principles and operating model of the Gateway, the features provided to users within the secure environment, and how we are approaching the challenges of making data safely accessible to increasing numbers of research users. The Gateway represents a powerful analytical environment and has been designed to be scalable and adaptable to meet the needs of the rapidly growing data linkage community.

  9. Characterization and evaluation of five jaboticaba accessions at the subtropical horticulture research station in Miami, Florida

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fruit of five Jaboticaba (Myrciaria caulifloria) cultivars ‘MC-05-06’, ‘MC-05-14’, ‘MC-05-12’, ‘MC-06-15,’ and ‘MC-06-14’ were evaluated and characterized at the National Germplasm Repository, Subtropical horticulture Research Station (SHRS) Miami, Florida. Thirty fruits were harvested from clona...

  10. Community Access to the C/NOFS Satellite Data -- Facilitating New Opportunities for Space Weather Research

    NASA Astrophysics Data System (ADS)

    Martin, S.; de La Beaujardiere, O.; Hunton, D.; Wilson, G.; Roddy, P.; Coley, R.; Heelis, R.; Earle, G.; Straus, P.; Bernhardt, P.; Bromund, K.; Candey, R.; Pfaff, R.; Rowland, D.; Holzworth, R.; Kessel, M.

    2008-12-01

    The Air Force Communication/Navigation Outage Forecasting System (C/NOFS) satellite was launched on April 17, 2008 into a low latitude orbit (401 by 867 km, 13 deg inclination) and is designed to understand, model, and forecast the presence of ionospheric irregularities that cause scintillations and other radiowave disruptions. Its instruments include those that sample the plasma density and temperature, DC/AC electric fields, DC magnetic fields, ion drift velocity, neutral density, and GPS occultations. A radiowave tomography experiment and a lightning detector are also included on the satellite. C/NOFS provides a tremendous opportunity to merge space-based and ground-based observations and research, while engendering comparisons with, and data input to, the latest ionospheric models and theoretical calculations and simulations. To help coordinate this research and exchange of data products, the C/NOFS satellite data will be made available to the community through the Coordinated Data Analysis web site (http://cdaweb.gsfc.nasa.gov/) that resides at the NASA/Goddard Space Flight Center. The data will be distributed via FTP, OPENDAP (data streaming), HTTP, and web services with output in CDF, ASCII listings, PDF, and PS formats. This activity is sponsored by the NASA/Living With a Star program. This data distribution web site is in addition to the main Air Force Research Laboratory web site for the C/NOFS program that is located at http://www.kirtland.af.mil/library/factsheets/factsheet.asp?id=12776 and includes links to the C/NOFS instrument web sites, ground-based research, and satellite updates. A description of the C/NOFS satellite instruments and their standard data products available to the community via the CDA web site will be provided.

  11. Litigation seeking access to data from ongoing clinical trials: a threat to clinical research.

    PubMed

    Kernan, Walter N; Viscoli, Catherine M; Varughese, Mathew C

    2014-09-01

    Researchers conducting randomized clinical trials may find themselves subject to legal subpoenas for interim data. When a subpoena demands premature disclosure of unblinded data, there is potential for damage to the scientific integrity and reputation of the on-going trial. We describe herein general issues raised by subpoenas for trial data and the particular case of a 2012 subpoena served on investigators from Yale University who were successful in winning reprieve from Connecticut Superior Court.

  12. Modeling the cell division cycle: cdc2 and cyclin interactions.

    PubMed Central

    Tyson, J J

    1991-01-01

    The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells. PMID:1831270

  13. Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation.

    PubMed

    Wang, Jirong R; Wang, Chaojun J; Xu, Chengyun Y; Wu, Xiaokai K; Hong, Dun; Shi, Wei; Gong, Ying; Chen, Haixiao X; Long, Fanxin; Wu, Ximei M

    2016-03-01

    Endochondral ossification consists of successive steps of chondrocyte differentiation, including mesenchymal condensation, differentiation of chondrocytes, and hypertrophy followed by mineralization and ossification. Loss-of-function studies have revealed that abnormal growth plate cartilage of the Cdc42 mutant contributes to the defects in endochondral bone formation. Here, we have investigated the roles of Cdc42 in osteogenesis and signaling cascades governing Cdc42-mediated chondrogenic differentiation. Though deletion of Cdc42 in limb mesenchymal progenitors led to severe defects in endochondral ossification, either ablation of Cdc42 in limb preosteoblasts or knockdown of Cdc42 in vitro had no obvious effects on bone formation and osteoblast differentiation. However, in Cdc42 mutant limb buds, loss of Cdc42 in mesenchymal progenitors led to marked inactivation of p38 and Smad1/5, and in micromass cultures, Cdc42 lay on the upstream of p38 to activate Smad1/5 in bone morphogenetic protein-2-induced mesenchymal condensation. Finally, Cdc42 also lay on the upstream of protein kinase B to transactivate Sox9 and subsequently induced the expression of chondrocyte differential marker in transforming growth factor-β1-induced chondrogenesis. Taken together, by using biochemical and genetic approaches, we have demonstrated that Cdc42 is involved not in osteogenesis but in chondrogenesis in which the BMP2/Cdc42/Pak/p38/Smad signaling module promotes mesenchymal condensation and the TGF-β/Cdc42/Pak/Akt/Sox9 signaling module facilitates chondrogenic differentiation.

  14. The researcher as experimental subject: using self-experimentation to access experiences, understand social phenomena, and stimulate reflexivity.

    PubMed

    Corti, Kevin; Reddy, Geetha; Choi, Ellen; Gillespie, Alex

    2015-06-01

    The current article argues that researcher-as-subject self-experimentation can provide valuable insight and systematic knowledge to social psychologists. This approach, the modus operandi of experimental psychology when the field was in its infancy, has been largely eclipsed by an almost exclusive focus on participant-as-subject other-experimentation. Drawing from the non-experimental first-person traditions of autoethnography, participant observation, and phenomenology, we argue that participating as both observer and subject within one's own social psychological experiment affords researchers at least three potential benefits: (1) access to "social qualia," that is, the subjective experience of social phenomena; (2) improved mental models of social phenomena, potentially stimulating new research questions; and (3) an enhanced ability to be reflexive about the given experiment. To support our position, we provide first-person self-reflections from researchers who have self-experimented with transformed social interactions involving Milgram's cyranoid method. We close by offering guidelines on how one might approach self-experimentation, and discuss a variety of first-person perspective ethnographic technologies that can be incorporated into the practice. PMID:25597036

  15. The researcher as experimental subject: using self-experimentation to access experiences, understand social phenomena, and stimulate reflexivity.

    PubMed

    Corti, Kevin; Reddy, Geetha; Choi, Ellen; Gillespie, Alex

    2015-06-01

    The current article argues that researcher-as-subject self-experimentation can provide valuable insight and systematic knowledge to social psychologists. This approach, the modus operandi of experimental psychology when the field was in its infancy, has been largely eclipsed by an almost exclusive focus on participant-as-subject other-experimentation. Drawing from the non-experimental first-person traditions of autoethnography, participant observation, and phenomenology, we argue that participating as both observer and subject within one's own social psychological experiment affords researchers at least three potential benefits: (1) access to "social qualia," that is, the subjective experience of social phenomena; (2) improved mental models of social phenomena, potentially stimulating new research questions; and (3) an enhanced ability to be reflexive about the given experiment. To support our position, we provide first-person self-reflections from researchers who have self-experimented with transformed social interactions involving Milgram's cyranoid method. We close by offering guidelines on how one might approach self-experimentation, and discuss a variety of first-person perspective ethnographic technologies that can be incorporated into the practice.

  16. Expanding Access to Secondary Schooling in Sub-Saharan Africa: Key Planning and Finance Issues. Create Pathways to Access. Research Monograph No. 8

    ERIC Educational Resources Information Center

    Lewin, Keith M.

    2007-01-01

    This paper makes the case for managed expansion of secondary schooling in Sub-Saharan Africa. The great majority of secondary age African children remain excluded from access to good quality secondary schooling. Increasing numbers are graduating from primary schools where enrolments are rapidly growing as a result of successful Education for All…

  17. Sustainable access to data, products, services and software from the European seismological Research Infrastructures: the EPOS TCS Seismology

    NASA Astrophysics Data System (ADS)

    Haslinger, Florian; Dupont, Aurelien; Michelini, Alberto; Rietbrock, Andreas; Sleeman, Reinoud; Wiemer, Stefan; Basili, Roberto; Bossu, Rémy; Cakti, Eser; Cotton, Fabrice; Crawford, Wayne; Diaz, Jordi; Garth, Tom; Locati, Mario; Luzi, Lucia; Pinho, Rui; Pitilakis, Kyriazis; Strollo, Angelo

    2016-04-01

    Easy, efficient and comprehensive access to data, data products, scientific services and scientific software is a key ingredient in enabling research at the frontiers of science. Organizing this access across the European Research Infrastructures in the field of seismology, so that it best serves user needs, takes advantage of state-of-the-art ICT solutions, provides cross-domain interoperability, and is organizationally and financially sustainable in the long term, is the core challenge of the implementation phase of the Thematic Core Service (TCS) Seismology within the EPOS-IP project. Building upon the existing European-level infrastructures ORFEUS for seismological waveforms, EMSC for seismological products, and EFEHR for seismological hazard and risk information, and implementing a pilot Computational Earth Science service starting from the results of the VERCE project, the work within the EPOS-IP project focuses on improving and extending the existing services, aligning them with global developments, to at the end produce a well coordinated framework that is technically, organizationally, and financially integrated with the EPOS architecture. This framework needs to respect the roles and responsibilities of the underlying national research infrastructures that are the data owners and main providers of data and products, and allow for active input and feedback from the (scientific) user community. At the same time, it needs to remain flexible enough to cope with unavoidable challenges in the availability of resources and dynamics of contributors. The technical work during the next years is organized in four areas: - constructing the next generation software architecture for the European Integrated (waveform) Data Archive EIDA, developing advanced metadata and station information services, fully integrate strong motion waveforms and derived parametric engineering-domain data, and advancing the integration of mobile (temporary) networks and OBS deployments in

  18. Lunar and Planetary Science XXXV: Undergraduate Education and Research Programs, Facilities, and Information Access

    NASA Technical Reports Server (NTRS)

    2004-01-01

    The titles in this section include: 1) GRIDVIEW: Recent Improvements in Research and Education Software for Exploring Mars Topography; 2) Software and Hardware Upgrades for the University of North Dakota Asteroid and Comet Internet Telescope (ACIT); 3) Web-based Program for Calculating Effects of an Earth Impact; 4) On-Line Education, Web- and Virtual-Classes in an Urban University: A Preliminary Overview; 5) Modelling Planetary Material's Structures: From Quasicrystalline Microstructure to Crystallographic Materials by Use of Mathematica; 6) How We Used NASA Lunar Set in Planetary and Material Science Studies: Textural and Cooling Sequences in Sections of Lava Column from a Thin and a Thick Lava-Flow, from the Moon and Mars with Terrestrial Analogue and Chondrule Textural Comparisons; 7) Classroom Teaching of Space Technology and Simulations by the Husar Rover Model; 8) New Experiments (In Meteorology, Aerosols, Soil Moisture and Ice) on the New Hunveyor Educational Planetary Landers of Universities and Colleges in Hungary; 9) Teaching Planetary GIS by Constructing Its Model for the Test Terrain of the Hunveyor and Husar; 10) Undergraduate Students: An Untapped Resource for Planetary Researchers; 11) Analog Sites in Field Work of Petrology: Rock Assembly Delivered to a Plain by Floods on Earth and Mars; 12) RELAB (Reflectance Experiment Laboratory): A NASA Multiuser Spectroscopy Facility; 13) Full Text Searching and Customization in the NASA ADS Abstract Service.

  19. Achieving recognition that mental health is part of the mission of CDC.

    PubMed

    Safran, Marc A

    2009-11-01

    For much of its history the U.S. Centers for Disease Control and Prevention (CDC) considered mental health to be outside of its mission. That assumption persisted even after CDC became a leading public health agency and began to face important mental health issues. This narrative describes how the organizational paradigm indicating that mental health was not mission related was challenged and superseded by a new paradigm recognizing mental health as part of CDC's public health mission. Even after the CDC Mental Health Work Group's establishment in 2000, CDC took eight more years to overcome powerful remnants of the old paradigm that had for so long excluded, minimized, or discouraged attention to mental health. The CDC Mental Health Work Group led the agency's mental health efforts without funding or dedicated staffing but with more than 100 CDC professionals from multiple disciplines and centers serving as voluntary members, in addition to their other CDC responsibilities.

  20. 75 FR 7606 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ...), Centers for Disease Control and Prevention (CDC): Notice of Charter Renewal This gives notice under the... Information: Anne C. Haddix, PhD, Designated Federal Officer, ACD, CDC, 1600 Clifton Road, NE., M/S...

  1. An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis.

    PubMed

    Unger, Christine; Popescu, Ruxandra; Giessrigl, Benedikt; Rarova, Lucie; Herbacek, Irene; Seelinger, Mareike; Diaz, Rene; Wallnöfer, Bruno; Fritzer-Szekeres, Monika; Szekeres, Thomas; Frisch, Richard; Doležal, Karel; Strnad, Miroslav; De Martin, Rainer; Grusch, Michael; Kopp, Brigitte; Krupitza, Georg

    2012-06-01

    Investigating the bioactivity of traditional medical remedies under the controlled conditions of a laboratory is an option to find additional applications, novel formulations or lead structures for the development of new drugs. The present work analysed the anti‑neoplastic activity of increasing polar extracts of the rainforest plant Critonia morifolia (Asteraceae) that has been successfully used as traditional remedy to treat various inflammatory conditions in the long-lasting medical tradition of the Central American Maya, which was here also confirmed in vitro. The apolar petroleum ether extract exhibited the most potent anti‑proliferative and pro‑apoptotic effects in HL‑60 cells and triggered down-regulation of Cdc25C and cyclin D1 within 30 min followed by the inhibition of c-Myc expression and the onset of caspase-3 activation within 2 h. Subsequent to these very rapid molecular responses Chk2 and H2AX became phosphorylated (γ‑H2AX) after 4 h. Analysis of the cell cycle distribution showed an accumulation of cells in the G2-M phase within 8 h and after 24 h in S-phase. This was temporally paralleled by the down-regulation of Cdc25A, Cdc25B, Wee1 and Akt. Therefore, the attenuation of cell cycle progression in the G2-M phase was consistent with the known role of Chk2 for G2-M arrest and with the role of Cdc25B in S-phase progression. These findings suggest the presence of two distinct active principles in the petroleum ether extract of C. moriflia. These facilitated the strong apoptotic response evidenced by the rapid activation of caspase-3 that was later enforced by the inhibition of the survival kinase Akt. Importantly, the efficient down-regulation of Akt, which is successfully tested in current clinical trials, is a unique property of C. morifolia. PMID:22446629

  2. Subsonic flutter analysis addition to NASTRAN. [for use with CDC 6000 series digital computers

    NASA Technical Reports Server (NTRS)

    Doggett, R. V., Jr.; Harder, R. L.

    1973-01-01

    A subsonic flutter analysis capability has been developed for NASTRAN, and a developmental version of the program has been installed on the CDC 6000 series digital computers at the Langley Research Center. The flutter analysis is of the modal type, uses doublet lattice unsteady aerodynamic forces, and solves the flutter equations by using the k-method. Surface and one-dimensional spline functions are used to transform from the aerodynamic degrees of freedom to the structural degrees of freedom. Some preliminary applications of the method to a beamlike wing, a platelike wing, and a platelike wing with a folded tip are compared with existing experimental and analytical results.

  3. Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer

    PubMed Central

    Lozada, Enerlyn M.; Andrysik, Zdenek; Yin, Moying; Redilla, Nicholas; Rice, Kathryn; Stambrook, Peter J.

    2016-01-01

    The dual specificity phosphatase Cdc25A is a key regulator of the cell cycle that promotes cell cycle progression by dephosphorylating and activating cyclin-dependent kinases. In response to genotoxicants, Cdc25A undergoes posttranslational modifications which contribute to its proteasome-mediated degradation and consequent cell cycle checkpoint arrest. The most thoroughly studied Cdc25A modification is phosphorylation. We now provide the first evidence that Cdc25A can be acetylated and that it directly interacts with the ARD1 acetyltransferase which acetylates Cdc25A both biochemically and in cultured cells. When acetylated, Cdc25A has an extended half-life. We have also identified the class IV histone deacetylase, HDAC11, as a Cdc25A deacetylase. We further show that DNA damage, such as exposure to methyl methanesulfonate (MMS), etoposide or arsenic, increases Cdc25A acetylation. Importantly, this acetylation modulates Cdc25A phosphatase activity and its function as a cell cycle regulator, and may reflect a cellular response to DNA damage. Since Cdc25A, ARD1, and HDAC11 are frequently dysregulated in multiple types of cancer, our findings may provide insight into a novel mechanism in carcinogenesis. PMID:26967250

  4. Biological and biochemical characterization of two new PLA2 isoforms Cdc-9 and Cdc-10 from Crotalus durissus cumanensis snake venom.

    PubMed

    Romero-Vargas, Frey Francisco; Ponce-Soto, Luis Alberto; Martins-de-Souza, Daniel; Marangoni, Sergio

    2010-01-01

    This work reports the purification, biological characterization and amino acid sequence of two new basic PLA(2) isoforms, Cdc-9 and Cdc-10, purified from the Crotalus durissus cumanensis venom by one step analytical chromatography reverse phase HPLC. The molecular masses of the PLA(2) were 14,175+/-2.7 Da for Cdc-9 and 14,228+/-3.5 Da for Cdc-10 both deduced by primary structure and confirmed by MALDI-TOF. The isoforms presented an amino acid sequence of 122 amino acid residues, being Cdc-9: SLVQFNKMIK FETRKSGLPF YAAYGCYCGW GGQRPKDATD RCCFVHDCCY GKVAKCNTKW DIYSYSLKSG YITCGKGTWC KEQICECDRV AAECLRRSLS TYKNEYMFYP DSRCREPPEY TC with pI value of 8.25 and Cdc-10: SLLQFNKMIK FETRKSGVPF YAAYGCYCGW GGRRPKDPTD RCCFVHDCCY GKLTKCNTKW DIYSYSLKSG YITCGKGTWC KEQICECDRV AAECLRRSLN TYKNEYMFYP DSRCRGPPEY TC with a pI value of 8.46, showing highly conserved Ca(2+)-binding and catalytic sites. The PLA(2) activity decreased when the isoforms Cdc-9 and Cdc-10 were incubated with 4-bromophenacyl bromide (p-BPB), anhydrous acetic acid and p-nitrobenzene sulfonyl fluoride (NBSF) when compared with the activity of both native isoforms. In mice, the PLA(2) isoforms Cdc-9 and Cdc-10 induced myonecrosis and edema. Myotoxic and edema activities were reduced after treatment of the isoforms with p-BPB; acetylation of the lysine residues and the treatment of PLA(2) with NBSF have also induced edema reduction. However, p-BPB strongly diminishes the local and systemic myotoxic effects.

  5. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

    PubMed

    Schlitzer, Andreas; Sivakamasundari, V; Chen, Jinmiao; Sumatoh, Hermi Rizal Bin; Schreuder, Jaring; Lum, Josephine; Malleret, Benoit; Zhang, Sanqian; Larbi, Anis; Zolezzi, Francesca; Renia, Laurent; Poidinger, Michael; Naik, Shalin; Newell, Evan W; Robson, Paul; Ginhoux, Florent

    2015-07-01

    Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8α(+) (CD103(+)) cDC1 lineage, and the CD11b(+) cDC2 lineage. cDCs arise from a cascade of bone marrow (BM) DC-committed progenitor cells that include the common DC progenitors (CDPs) and pre-DCs, which exit the BM and seed peripheral tissues before differentiating locally into mature cDCs. Where and when commitment to the cDC1 or cDC2 lineage occurs remains poorly understood. Here we found that transcriptional signatures of the cDC1 and cDC2 lineages became evident at the single-cell level from the CDP stage. We also identified Siglec-H and Ly6C as lineage markers that distinguished pre-DC subpopulations committed to the cDC1 lineage (Siglec-H(-)Ly6C(-) pre-DCs) or cDC2 lineage (Siglec-H(-)Ly6C(+) pre-DCs). Our results indicate that commitment to the cDC1 or cDC2 lineage occurs in the BM and not in the periphery.

  6. Interface of the transport systems research vehicle monochrome display system to the digital autonomous terminal access communication data bus

    NASA Technical Reports Server (NTRS)

    Easley, W. C.; Tanguy, J. S.

    1986-01-01

    An upgrade of the transport systems research vehicle (TSRV) experimental flight system retained the original monochrome display system. The original host computer was replaced with a Norden 11/70, a new digital autonomous terminal access communication (DATAC) data bus was installed for data transfer between display system and host, while a new data interface method was required. The new display data interface uses four split phase bipolar (SPBP) serial busses. The DATAC bus uses a shared interface ram (SIR) for intermediate storage of its data transfer. A display interface unit (DIU) was designed and configured to read from and write to the SIR to properly convert the data from parallel to SPBP serial and vice versa. It is found that separation of data for use by each SPBP bus and synchronization of data tranfer throughout the entire experimental flight system are major problems which require solution in DIU design. The techniques used to accomplish these new data interface requirements are described.

  7. Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae

    PubMed Central

    Finnigan, Gregory C.; Takagi, Julie; Cho, Christina; Thorner, Jeremy

    2015-01-01

    Septins are a family of GTP-binding proteins considered to be cytoskeletal elements because they self-assemble into filaments and other higher-order structures in vivo. In budding yeast, septins establish a diffusion barrier at the bud neck between a mother and daughter cell, promote membrane curvature there, and serve as a scaffold to recruit other proteins to the site of cytokinesis. However, the mechanism by which any septin engages a partner protein has been unclear. The two most related and recently evolved subunits appear to be Cdc11 and Shs1, and the basic building blocks for assembling septin structures are hetero-octameric rods (Cdc11–Cdc12–Cdc3–Cdc10–Cdc10–Cdc3–Cdc12–Cdc11 and Shs1–Cdc12–Cdc3–Cdc10–Cdc10–Cdc3–Cdc12–Shs1). Loss of Cdc11 is not normally tolerated, whereas cells lacking Shs1 do not appear grossly abnormal. We established several different sensitized genetic backgrounds wherein Shs1 is indispensable, which allowed us to carry out the first comprehensive and detailed genetic analysis of Shs1 in vivo. Our analysis revealed several novel insights, including: (i) the sole portion of Shs1 essential for its function is a predicted coiled-coil-forming segment in its C-terminal extension (CTE); (ii) the CTE of Cdc11 shares this function; (iii) this role for the CTEs of Cdc11 and Shs1 is quite distinct from that of the CTEs of Cdc3 and Cdc12; and (iv) heterotypic Cdc11 and Shs1 junctions likely occur in vivo. Related article in GENETICS: Finnigan, G. C. et al., 2015 The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae. Genetics 200: 843–862. PMID:25971665

  8. Article processing charges for open access publication-the situation for research intensive universities in the USA and Canada.

    PubMed

    Solomon, David; Björk, Bo-Christer

    2016-01-01

    Background. Open access (OA) publishing via article processing charges (APCs) is growing as an alternative to subscription publishing. The Pay It Forward (PIF) Project is exploring the feasibility of transitioning from paying subscriptions to funding APCs for faculty at research intensive universities. Estimating of the cost of APCs for the journals authors at research intensive universities tend to publish is essential for the PIF project and similar initiatives. This paper presents our research into this question. Methods. We identified APC prices for publications by authors at the 4 research intensive United States (US) and Canadian universities involved in the study. We also obtained APC payment records from several Western European universities and funding agencies. Both data sets were merged with Web of Science (WoS) metadata. We calculated the average APCs for articles and proceedings in 13 discipline categories published by researchers at research intensive universities. We also identified 41 journals published by traditionally subscription publishers which have recently converted to APC funded OA and recorded the APCs they charge. Results. We identified 7,629 payment records from the 4 European APC payment databases and 14,356 OA articles authored by PIF partner university faculty for which we had listed APC prices. APCs for full OA journals published by PIF authors averaged 1,775 USD; full OA journal APCs paid by Western European funders averaged 1,865 USD; hybrid APCs paid by Western European funders averaged 2,887 USD. The APC for converted journals published by major subscription publishers averaged 1,825 USD. APC funded OA is concentrated in the life and basic sciences. APCs funded articles in the social sciences and humanities are often multidisciplinary and published in journals such as PLOS ONE that largely publish in the life sciences. Conclusions. Full OA journal APCs average a little under 2,000 USD while hybrid articles average about 3,000 USD

  9. Alternatives to project-specific consent for access to personal information for health research: Insights from a public dialogue

    PubMed Central

    Willison, Donald J; Swinton, Marilyn; Schwartz, Lisa; Abelson, Julia; Charles, Cathy; Northrup, David; Cheng, Ji; Thabane, Lehana

    2008-01-01

    Background The role of consent for research use of health information is contentious. Most discussion has focused on when project-specific consent may be waived but, recently, a broader range of consent options has been entertained, including broad opt-in for multiple studies with restrictions and notification with opt-out. We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues. Methods We conducted seven day-long public dialogues, involving 98 participants across Canada. Immediately before and after each dialogue, participants completed a fixed-response questionnaire rating individuals' support for 3 approaches to consent in the abstract and their consent choices for 5 health research scenarios using personal information. They also rated how confident different safeguards made them feel that their information was being used responsibly. Results Broad opt-in consent for use of personal information garnered the greatest support in the abstract. When presented with specific research scenarios, no one approach to consent predominated. When profit was introduced into the scenarios, consent choices shifted toward greater control over use. Despite lively and constructive dialogues, and considerable shifting in opinion at the individual level, at the end of the day, there was no substantive aggregate movement in opinion. Personal controls were among the most commonly cited approaches to improving people's confidence in the responsible use of their information for research. Conclusion Because no one approach to consent satisfied even a simple majority of dialogue participants and the importance placed on personal controls, a mechanism should be developed for documenting consent choice for different types of research, including ways for individuals to check who has accessed their medical record for purposes other than

  10. Article processing charges for open access publication—the situation for research intensive universities in the USA and Canada

    PubMed Central

    Björk, Bo-Christer

    2016-01-01

    Background. Open access (OA) publishing via article processing charges (APCs) is growing as an alternative to subscription publishing. The Pay It Forward (PIF) Project is exploring the feasibility of transitioning from paying subscriptions to funding APCs for faculty at research intensive universities. Estimating of the cost of APCs for the journals authors at research intensive universities tend to publish is essential for the PIF project and similar initiatives. This paper presents our research into this question. Methods. We identified APC prices for publications by authors at the 4 research intensive United States (US) and Canadian universities involved in the study. We also obtained APC payment records from several Western European universities and funding agencies. Both data sets were merged with Web of Science (WoS) metadata. We calculated the average APCs for articles and proceedings in 13 discipline categories published by researchers at research intensive universities. We also identified 41 journals published by traditionally subscription publishers which have recently converted to APC funded OA and recorded the APCs they charge. Results. We identified 7,629 payment records from the 4 European APC payment databases and 14,356 OA articles authored by PIF partner university faculty for which we had listed APC prices. APCs for full OA journals published by PIF authors averaged 1,775 USD; full OA journal APCs paid by Western European funders averaged 1,865 USD; hybrid APCs paid by Western European funders averaged 2,887 USD. The APC for converted journals published by major subscription publishers averaged 1,825 USD. APC funded OA is concentrated in the life and basic sciences. APCs funded articles in the social sciences and humanities are often multidisciplinary and published in journals such as PLOS ONE that largely publish in the life sciences. Conclusions. Full OA journal APCs average a little under 2,000 USD while hybrid articles average about 3,000 USD

  11. Article processing charges for open access publication-the situation for research intensive universities in the USA and Canada.

    PubMed

    Solomon, David; Björk, Bo-Christer

    2016-01-01

    Background. Open access (OA) publishing via article processing charges (APCs) is growing as an alternative to subscription publishing. The Pay It Forward (PIF) Project is exploring the feasibility of transitioning from paying subscriptions to funding APCs for faculty at research intensive universities. Estimating of the cost of APCs for the journals authors at research intensive universities tend to publish is essential for the PIF project and similar initiatives. This paper presents our research into this question. Methods. We identified APC prices for publications by authors at the 4 research intensive United States (US) and Canadian universities involved in the study. We also obtained APC payment records from several Western European universities and funding agencies. Both data sets were merged with Web of Science (WoS) metadata. We calculated the average APCs for articles and proceedings in 13 discipline categories published by researchers at research intensive universities. We also identified 41 journals published by traditionally subscription publishers which have recently converted to APC funded OA and recorded the APCs they charge. Results. We identified 7,629 payment records from the 4 European APC payment databases and 14,356 OA articles authored by PIF partner university faculty for which we had listed APC prices. APCs for full OA journals published by PIF authors averaged 1,775 USD; full OA journal APCs paid by Western European funders averaged 1,865 USD; hybrid APCs paid by Western European funders averaged 2,887 USD. The APC for converted journals published by major subscription publishers averaged 1,825 USD. APC funded OA is concentrated in the life and basic sciences. APCs funded articles in the social sciences and humanities are often multidisciplinary and published in journals such as PLOS ONE that largely publish in the life sciences. Conclusions. Full OA journal APCs average a little under 2,000 USD while hybrid articles average about 3,000 USD

  12. CDC Warns of Dangers of Plastic Surgery in Dominican Republic

    MedlinePlus

    ... gov/news/fullstory_159884.html CDC Warns of Dangers of Plastic Surgery in Dominican Republic Report details cases of U.S. women who developed disfiguring infections after procedures there To ... health officials are warning about the dangers of "medical tourism" after at least 18 women ...

  13. More Health Care Workers Need Flu Shots: CDC

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_161257.html More Health Care Workers Need Flu Shots: CDC Vaccination protects both ... FRIDAY, Sept. 30, 2016 (HealthDay News) -- More U.S. health care workers need to get their annual flu shots, ...

  14. U.S. Teen Births Hit Another Record Low: CDC

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_161207.html U.S. Teen Births Hit Another Record Low: CDC Less sex, ... Sept. 28, 2016 (HealthDay News) -- Births to U.S. teens reached a record low last year, continuing a ...

  15. Cdc45 is limiting for replication initiation in humans

    PubMed Central

    Köhler, Carsten; Koalick, Dennis; Fabricius, Anja; Parplys, Ann Christin; Borgmann, Kerstin; Pospiech, Helmut; Grosse, Frank

    2016-01-01

    ABSTRACT Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as control cells. However, these cells displayed an about 2-fold diminished fork elongation rate, a pronounced asymmetry of replication fork extension, and an early S phase arrest. This was accompanied by H2AX-phosphorylation and subsequent apoptosis. Unexpectedly, we did not observe increased ATR/Chk1 signaling but rather a mild ATM/Chk2 response. In addition, we detected accumulation of long stretches of single-stranded DNA, a hallmark of replication catastrophe. We conclude that increased origin firing by upregulated Cdc45 caused exhaustion of the single-strand binding protein RPA, which in consequence diminished the ATR/Chk1 response; the subsequently occurring fork breaks led to an ATM/Chk2 mediated phosphorylation of H2AX and eventually to apoptosis. PMID:26919204

  16. Sexually Transmitted Diseases Hit All-Time High: CDC

    MedlinePlus

    ... news/fullstory_161565.html Sexually Transmitted Diseases Hit All-Time High: CDC More prevention efforts needed, agency ... Oct. 19, 2016 HealthDay Copyright (c) 2016 HealthDay . All rights reserved. News stories are provided by HealthDay ...

  17. Opportunities and Barriers to Rural, Remote and First Nation Health Services Research in Canada: Comparing Access to Administrative Claims Data in Manitoba and British Columbia.

    PubMed

    Lavoie, Josée G; Wong, Sabrina; Katz, Alan; Sinclair, Stephanie

    2016-08-01

    Access to geographically disaggregated data is essential for the pursuit of meaningful rural, remote and First Nation health services research. This paper explores the opportunities and challenges associated with undertaking administrative claims data research in the context of two different models of administrative data management: the Manitoba and British Columbia models. We argue that two conditions must be in place to support rural, remote and First Nation health services research: (1) pathways to data access that reconcile the need to protect privacy with the imperative to conduct analyses on disaggregated data; and (2) a trust-based relationship with data providers. PMID:27585026

  18. Opportunities and Barriers to Rural, Remote and First Nation Health Services Research in Canada: Comparing Access to Administrative Claims Data in Manitoba and British Columbia.

    PubMed

    Lavoie, Josée G; Wong, Sabrina; Katz, Alan; Sinclair, Stephanie

    2016-08-01

    Access to geographically disaggregated data is essential for the pursuit of meaningful rural, remote and First Nation health services research. This paper explores the opportunities and challenges associated with undertaking administrative claims data research in the context of two different models of administrative data management: the Manitoba and British Columbia models. We argue that two conditions must be in place to support rural, remote and First Nation health services research: (1) pathways to data access that reconcile the need to protect privacy with the imperative to conduct analyses on disaggregated data; and (2) a trust-based relationship with data providers.

  19. Opportunities and Barriers to Rural, Remote and First Nation Health Services Research in Canada: Comparing Access to Administrative Claims Data in Manitoba and British Columbia

    PubMed Central

    Wong, Sabrina; Katz, Alan; Sinclair, Stephanie

    2016-01-01

    Access to geographically disaggregated data is essential for the pursuit of meaningful rural, remote and First Nation health services research. This paper explores the opportunities and challenges associated with undertaking administrative claims data research in the context of two different models of administrative data management: the Manitoba and British Columbia models. We argue that two conditions must be in place to support rural, remote and First Nation health services research: (1) pathways to data access that reconcile the need to protect privacy with the imperative to conduct analyses on disaggregated data; and (2) a trust-based relationship with data providers. PMID:27585026

  20. The case for developing publicly-accessible datasets for health services research in the Middle East and North Africa (MENA) region

    PubMed Central

    Saleh, Shadi S; Alameddine, Mohamad S; El-Jardali, Fadi

    2009-01-01

    Background The existence of publicly-accessible datasets comprised a significant opportunity for health services research to evolve into a science that supports health policy making and evaluation, proper inter- and intra-organizational decisions and optimal clinical interventions. This paper investigated the role of publicly-accessible datasets in the enhancement of health care systems in the developed world and highlighted the importance of their wide existence and use in the Middle East and North Africa (MENA) region. Discussion A search was conducted to explore the availability of publicly-accessible datasets in the MENA region. Although datasets were found in most countries in the region, those were limited in terms of their relevance, quality and public-accessibility. With rare exceptions, publicly-accessible datasets - as present in the developed world - were absent. Based on this, we proposed a gradual approach and a set of recommendations to promote the development and use of publicly-accessible datasets in the region. These recommendations target potential actions by governments, researchers, policy makers and international organizations. Summary We argue that the limited number of publicly-accessible datasets in the MENA region represents a lost opportunity for the evidence-based advancement of health systems in the region. The availability and use of publicly-accessible datasets would encourage policy makers in this region to base their decisions on solid representative data and not on estimates or small-scale studies; researchers would be able to exercise their expertise in a meaningful manner to both, policy makers and the public. The population of the MENA countries would exercise the right to benefit from locally- or regionally-based studies, versus imported and in 'best cases' customized ones. Furthermore, on a macro scale, the availability of regionally comparable publicly-accessible datasets would allow for the exploration of regional variations

  1. Caffeine stabilizes Cdc25 independently of Rad3 in Schizosaccharomyces pombe contributing to checkpoint override.

    PubMed

    Alao, John P; Sjölander, Johanna J; Baar, Juliane; Özbaki-Yagan, Nejla; Kakoschky, Bianca; Sunnerhagen, Per

    2014-05-01

    Cdc25 is required for Cdc2 dephosphorylation and is thus essential for cell cycle progression. Checkpoint activation requires dual inhibition of Cdc25 and Cdc2 in a Rad3-dependent manner. Caffeine is believed to override activation of the replication and DNA damage checkpoints by inhibiting Rad3-related proteins in both Schizosaccharomyces pombe and mammalian cells. In this study, we have investigated the impact of caffeine on Cdc25 stability, cell cycle progression and checkpoint override. Caffeine induced Cdc25 accumulation in S. pombe independently of Rad3. Caffeine delayed cell cycle progression under normal conditions but advanced mitosis in cells treated with replication inhibitors and DNA-damaging agents. In the absence of Cdc25, caffeine inhibited cell cycle progression even in the presence of hydroxyurea or phleomycin. Caffeine induces Cdc25 accumulation in S. pombe by suppressing its degradation independently of Rad3. The induction of Cdc25 accumulation was not associated with accelerated progression through mitosis, but rather with delayed progression through cytokinesis. Caffeine-induced Cdc25 accumulation appears to underlie its ability to override cell cycle checkpoints. The impact of Cdc25 accumulation on cell cycle progression is attenuated by Srk1 and Mad2. Together our findings suggest that caffeine overrides checkpoint enforcement by inducing the inappropriate nuclear localization of Cdc25.

  2. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following...

  3. 76 FR 62071 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ...), Centers for Disease Control and Prevention (CDC) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), CDC announces the following meeting of the aforementioned committee. Time and date: 8:30 a.m.-2:30 p.m., October 27, 2011. Place: CDC, 1600 Clifton Road,...

  4. 78 FR 64503 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...), Centers for Disease Control and Prevention (CDC) Cancellation: This notice was published in the Federal..., Committee Management Specialist, Office Chief of Staff, CDC, 1600 Clifton Road NE., Mail Stop D-14, Atlanta, Georgia 30303, Telephone: (404) 639-7158, Fax: (404) 639-7212, Email: ghickman@cdc.gov . This notice...

  5. 13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee....

  6. 78 FR 18602 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ...), Centers for Disease Control and Prevention (CDC) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the.... Place: CDC, Building 21, Rooms 1204 A/B, 1600 Clifton Road, NE., Atlanta, Georgia 30333. Status: Open...

  7. 78 FR 60876 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...), Centers for Disease Control and Prevention (CDC) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the... Place: CDC, Building 21, Rooms 1204 A/B, 1600 Clifton Road, NE., Atlanta, Georgia 30333. Status: Open...

  8. 13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee....

  9. 78 FR 60876 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...), Centers for Disease Control and Prevention (CDC) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the..., 2013. Place: CDC, Building 21, Rooms 1204 A/B, 1600 Clifton Road NE., Atlanta, Georgia 30333....

  10. 13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee....

  11. 13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee....

  12. 13 CFR 120.950 - SBA and CDC must appoint agents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false SBA and CDC must appoint agents... Development Company Loan Program (504) Debenture Sales and Service Agents § 120.950 SBA and CDC must appoint agents. SBA and the CDC must appoint the following agents to facilitate the sale and service of...

  13. 13 CFR 120.950 - SBA and CDC must appoint agents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBA and CDC must appoint agents... Development Company Loan Program (504) Debenture Sales and Service Agents § 120.950 SBA and CDC must appoint agents. SBA and the CDC must appoint the following agents to facilitate the sale and service of...

  14. 13 CFR 120.972 - Third Party Lender participation fee and CDC fee.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... fee and CDC fee. 120.972 Section 120.972 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... and CDC fee. (a) Participation fee. For loans approved by SBA after September 30, 1996, SBA must... when the Third Party Lender occupies a senior credit position to SBA in the Project. (b) CDC fee....

  15. 13 CFR 120.950 - SBA and CDC must appoint agents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false SBA and CDC must appoint agents... Development Company Loan Program (504) Debenture Sales and Service Agents § 120.950 SBA and CDC must appoint agents. SBA and the CDC must appoint the following agents to facilitate the sale and service of...

  16. 33 CFR 105.295 - Additional requirements-Certain Dangerous Cargo (CDC) facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Dangerous Cargo (CDC) facilities. 105.295 Section 105.295 Navigation and Navigable Waters COAST GUARD... Requirements § 105.295 Additional requirements-Certain Dangerous Cargo (CDC) facilities. (a) At all MARSEC Levels, owners or operators of CDC facilities must ensure the implementation of the following...

  17. 13 CFR 120.950 - SBA and CDC must appoint agents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false SBA and CDC must appoint agents... Development Company Loan Program (504) Debenture Sales and Service Agents § 120.950 SBA and CDC must appoint agents. SBA and the CDC must appoint the following agents to facilitate the sale and service of...

  18. 75 FR 62844 - Advisory Committee to the Director (ACD), Centers for Disease Control and Prevention (CDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ...), Centers for Disease Control and Prevention (CDC) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), the CDC announces the following meeting of the aforementioned committee: Time and Date: 8:30 a.m.-3 p.m., October 28, 2010. Place: CDC, 1600 Clifton Road, NE.,...

  19. 13 CFR 120.950 - SBA and CDC must appoint agents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false SBA and CDC must appoint agents... Development Company Loan Program (504) Debenture Sales and Service Agents § 120.950 SBA and CDC must appoint agents. SBA and the CDC must appoint the following agents to facilitate the sale and service of...

  20. Modeling the fission yeast cell cycle: Quantized cycle times in wee1 cdc25 mutant cells

    NASA Astrophysics Data System (ADS)

    Sveiczer, Akos; Csikasz-Nagy, Attila; Gyorffy, Bela; Tyson, John J.; Novak, Bela

    2000-07-01

    A detailed mathematical model for the fission yeast mitotic cycle is developed based on positive and negative feedback loops by which Cdc13/Cdc2 kinase activates and inactivates itself. Positive feedbacks are created by Cdc13/Cdc2-dependent phosphorylation of specific substrates: inactivating its negative regulators (Rum1, Ste9 and Wee1/Mik1) and activating its positive regulator (Cdc25). A slow negative feedback loop is turned on during mitosis by activation of Slp1/anaphase-promoting complex (APC), which indirectly re-activates the negative regulators, leading to a drop in Cdc13/Cdc2 activity and exit from mitosis. The model explains how fission yeast cells can exit mitosis in the absence of Ste9 (Cdc13 degradation) and Rum1 (an inhibitor of Cdc13/Cdc2). We also show that, if the positive feedback loops accelerating the G2/M transition (through Wee1 and Cdc25) are weak, then cells can reset back to G2 from early stages of mitosis by premature activation of the negative feedback loop. This resetting can happen more than once, resulting in a quantized distribution of cycle times, as observed experimentally in wee1- cdc25Delta mutant cells. Our quantitative description of these quantized cycles demonstrates the utility of mathematical modeling, because these cycles cannot be understood by intuitive arguments alone.