Sample records for access ma array

  1. Larger sized wire arrays on 1.5 MA Z-pinch generator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Safronova, A. S., E-mail: alla@unr.edu; Kantsyrev, V. L., E-mail: alla@unr.edu; Weller, M. E., E-mail: alla@unr.edu

    Experiments on the UNR Zebra generator with Load Current Multiplier (LCM) allow for implosions of larger sized wire array loads than at standard current of 1 MA. Advantages of larger sized planar wire array implosions include enhanced energy coupling to plasmas, better diagnostic access to observable plasma regions, and more complex geometries of the wire loads. The experiments with larger sized wire arrays were performed on 1.5 MA Zebra with LCM (the anode-cathode gap was 1 cm, which is half the gap used in the standard mode). In particular, larger sized multi-planar wire arrays had two outer wire planes frommore » mid-atomic-number wires to create a global magnetic field (gmf) and plasma flow between them. A modified central plane with a few Al wires at the edges was put in the middle between outer planes to influence gmf and to create Al plasma flow in the perpendicular direction (to the outer arrays plasma flow). Such modified plane has different number of empty slots: it was increased from 6 up to 10, hence increasing the gap inside the middle plane from 4.9 to 7.7 mm, respectively. Such load configuration allows for more independent study of the flows of L-shell mid-atomic-number plasma (between the outer planes) and K-shell Al plasma (which first fills the gap between the edge wires along the middle plane) and their radiation in space and time. We demonstrate that such configuration produces higher linear radiation yield and electron temperatures as well as advantages of better diagnostics access to observable plasma regions and how the load geometry (size of the gap in the middle plane) influences K-shell Al radiation. In particular, K-shell Al radiation was delayed compared to L-shell mid-atomic-number radiation when the gap in the middle plane was large enough (when the number of empty slots was increased up to ten)« less

  2. Comparative Study of Antenna Elements for TDRSS Enhanced Multiple Access System

    NASA Technical Reports Server (NTRS)

    Kory, Carol L.; Lambert, Kevin; Acosta, Roberto; Nessel, James

    2006-01-01

    We compare three antennas, which are candidates for the TDRSS-Continuation enhanced MA array antenna elements. Measured and simulated data show very good agreement for all antenna elements. All of the antennas meet the specifications with the exception of the SBA isolation. However, improvements can likely be made with further design efforts.

  3. Power reduction by power gating in differential pair type spin-transfer-torque magnetic random access memories for low-power nonvolatile cache memories

    NASA Astrophysics Data System (ADS)

    Ohsawa, Takashi; Ikeda, Shoji; Hanyu, Takahiro; Ohno, Hideo; Endoh, Tetsuo

    2014-01-01

    Array operation currents in spin-transfer-torque magnetic random access memories (STT-MRAMs) that use four differential pair type magnetic tunnel junction (MTJ)-based memory cells (4T2MTJ, two 6T2MTJs and 8T2MTJ) are simulated and compared with that in SRAM. With L3 cache applications in mind, it is assumed that the memories are composed of 32 Mbyte capacity to be accessed in 64 byte in parallel. All the STT-MRAMs except for the 8T2MTJ one are designed with 32 bit fine-grained power gating scheme applied to eliminate static currents in the memory cells that are not accessed. The 8T2MTJ STT-MRAM, the cell’s design concept being not suitable for the fine-grained power gating, loads and saves 32 Mbyte data in 64 Mbyte unit per 1 Mbit sub-array in 2 × 103 cycles. It is shown that the array operation current of the 4T2MTJ STT-MRAM is 70 mA averaged in 15 ns write cycles at Vdd = 0.9 V. This is the smallest among the STT-MRAMs, about the half of the low standby power (LSTP) SRAM whose array operation current is totally dominated by the cells’ subthreshold leakage.

  4. New Regimes of Implosions of Larger Sized Wire Arrays With and Without Modified Central Plane at 1.5-1.7 MA Zebra

    NASA Astrophysics Data System (ADS)

    Safronova, A. S.; Kantsyrev, V. L.; Esaulov, A. A.; Weller, M. E.; Shrestha, I.; Shlyaptseva, V. V.; Stafford, A.; Keim, S. F.; Petkov, E. E.; Lorance, M.; Chuvatin, A. S.; Coverdale, C. A.; Jones, B.

    2013-10-01

    The recent experiments at 1.5-1.7 MA on Zebra at UNR with larger sized planar wires arrays (compared to the wire loads at 1 MA current) have demonstrated higher linear radiation yield and electron temperatures as well as advantages of better diagnostics access to observable plasma regions. Such multi-planar wire arrays had two outer wire planes from mid-Z material to create a global magnetic field (gmf) and mid-Z plasma flow between them. Also, they included a modified central plane with a few Al wires at the edges to influence gmf and to create Al plasma flow in the perpendicular direction. The stationary shock waves which existed over tens of ns on shadow images and the early x-ray emissions before the PCD peak on time-gated spectra were observed. The most recent experiments with similar loads but without the central wires demonstrated a very different regime of implosion with asymmetrical jets and no precursor formation. This work was supported by NNSA under DOE Cooperative Agreement DE-NA0001984 and in part by DE-FC52-06NA27616. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  5. A Microstrip Patch-Fed Short Backfire Antenna for the Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) Array

    NASA Technical Reports Server (NTRS)

    Nessel, James A.; Kory, Carol L.; Lambert, Kevin M.; Acosta, Roberto J.

    2006-01-01

    Short Backfire Antennas (SBAs) are widely utilized for mobile satellite communications, tracking, telemetry, and wireless local area network (WLAN) applications due to their compact structure and excellent radiation characteristics [1-3]. Typically, these SBA s consist of an excitation element (i.e., a half-wavelength dipole), a reflective bottom plane, a planar sub-reflector located above the "exciter", and an outer circular rim. This configuration is capable of achieving gains on the order of 13-15 dBi, but with relatively narrow bandwidths (approx.3%-5%), making it incompatible with the requirements of the next generation enhanced Tracking and Data Relay Satellite System-Continuation (TDRSS-C) Multiple Access (MA) array [1]. Several attempts have been made to enhance the bandwidth performance of the common dipole-fed SBA by employing various other feeding mechanisms (e.g., waveguide, slot) with moderate success [4-5]. In this paper, a novel method of using a microstrip patch is employed for the first time to excite an SBA. The patch element is fed via two H-shaped slots electromagnetically coupled to a broadband hybrid coupler to maintain a wide bandwidth, as well as provide for dual circular polarization capabilities.

  6. Time of day influences the voluntary intake and behavioral response to methamphetamine and food reward.

    PubMed

    Keith, Diana R; Hart, Carl L; Robotham, Margaret; Tariq, Maliha; Le Sauter, Joseph; Silver, Rae

    2013-09-01

    The circadian timing system influences a vast array of behavioral responses. Substantial evidence indicates a role for the circadian system in regulating reward processing. Here we explore time of day effects on drug anticipation, locomotor activity, and voluntary methamphetamine (MA) and food intake in animals with ad libitum food access. We compared responses to drug versus a palatable treat during their normal sleep times in early day (zeitgeber time (ZT) 0400) or late day (ZT 1000). In the first study, using a between-subjects design, mice were given daily 1-h access to either peanut butter (PB-Alone) or to a low or high concentration of MA mixed in PB (MA+PB). In study 2, we repeated the experiment using a within-subjects design in which mice could choose between PB-Alone and MA+PB at either ZT 0400 or 1000. In study 3, the effects of MA-alone were investigated by evaluating anticipatory activity preceding exposure to nebulized MA at ZT 0400 vs. ZT 1000. Time of day effects were observed for both drug and palatable treat, such that in the between groups design, animals showed greater intake, anticipatory activity, and post-ingestional activity in the early day. Furthermore, there were differences among mice in the amount of MA ingested but individuals were self-consistent in their daily intake. The results for the within-subjects experiment also revealed robust individual differences in preference for MA+PB or PB-Alone. Interestingly, time of day effects on intake were observed only for the preferred substance. Anticipatory activity preceding administration of MA by nebulization was also greater at ZT 0400 than ZT 1000. Finally, pharmacokinetic response to MA administered intraperitoneally did not vary as a function of time of administration. The results indicate that time of day is an important variable mediating the voluntary intake and behavioral effects of reinforcers. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. FeP@C Nanotube Arrays Grown on Carbon Fabric as a Low Potential and Freestanding Anode for High-Performance Li-Ion Batteries.

    PubMed

    Xu, Xijun; Liu, Jun; Liu, Zhengbo; Wang, Zhuosen; Hu, Renzong; Liu, Jiangwen; Ouyang, Liuzhang; Zhu, Min

    2018-06-26

    An anode of self-supported FeP@C nanotube arrays on carbon fabric (CF) is successfully fabricated via a facile template-based deposition and phosphorization route: first, well-aligned FeOOH nanotube arrays are simply obtained via a solution deposition and in situ etching route with hydrothermally crystallized (Co,Ni)(CO 3 ) 0.5 OH nanowire arrays as the template; subsequently, these uniform FeOOH nanotube arrays are transformed into robust carbon-coated Fe 3 O 4 (Fe 3 O 4 @C) nanotube arrays via glucose adsorption and annealing treatments; and finally FeP@C nanotube arrays on CF are achieved through the facile phosphorization of the oxide-based arrays. As an anode for lithium-ion batteries (LIBs), these FeP@C nanotube arrays exhibit superior rate capability (reversible capacities of 945, 871, 815, 762, 717, and 657 mA h g -1 at 0.1, 0.2, 0.4, 0.8, 1.3, and 2.2 A g -1 , respectively, corresponding to area specific capacities of 1.73, 1.59, 1.49, 1.39, 1.31, 1.20 mA h cm -2 at 0.18, 0.37, 0.732, 1.46, 2.38, and 4.03 mA cm -2 , respectively) and a stable long-cycling performance (a high specific capacity of 718 mA h g -1 after 670 cycles at 0.5 A g -1 , corresponding to an area capacity of 1.31 mA h cm -2 at 0.92 mA cm -2 ). © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Payload Performance of TDRS KL and Future Services

    NASA Technical Reports Server (NTRS)

    Toral, Marco A.; Heckler, Gregory W.; Pogorelc, Patricia M.; George, Nicholas E.; Han, Katherine S.

    2017-01-01

    NASA has accepted two of the 3nd generation Tracking and Data Relay Satellites, TDRS K, L, and M, designed and built by Boeing Defense, Space Security (DSS). TDRS K, L, and M provide S-band Multiple Access (MA) service and S-band, Ku-band and Ka-band Single Access (SA) services to near Earth orbiting satellites. The TDRS KLM satellites offer improved services relative to the 1st generation TDRS spacecraft, such as: an enhanced MA service featuring increased EIRPs and GT; and Ka-band SA capability which provides a 225 and 650 MHz return service (customer-to-TDRS direction) bandwidth and a 50 MHz forward service (TDRS-to-customer direction) bandwidth. MA services are provided through a 15 element forward phased array that forms up to two beams with onboard active beamforming and a 32 element return phased array supported by ground-based beamforming. SA services are provided through two 4.6m tri-band reflector antennas which support program track pointing and autotrack pointing. Prior to NASAs acceptance of the satellites, payload on-orbit testing was performed on each satellite to determine on-orbit compliance with design requirements. Performance parameters evaluated include: EIRP, GT, antenna gain patterns, SA antenna autotrack performance, and radiometric tracking performance. On-orbit antenna calibration and pointing optimization was also performed on the MA and SA antennas including 24 hour duration tests to characterize and calibrate out diurnal effects. Bit-Error-Rate (BER) tests were performed to evaluate the end-to-end link BER performance of service through a TDRS K and L spacecraft. The TDRS M is planned to be launched in August 2017. This paper summarizes the results of the TDRS KL communications payload on-orbit performance verification and end-to-end service characterization and compares the results with the performance of the 2nd generation TDRS J. The paper also provides a high-level overview of an optical communications application that will augment the data rates supported by the Space Network.

  9. Payload Performance of Third Generation TDRS and Future Services

    NASA Technical Reports Server (NTRS)

    Toral, Marco; Heckler, Gregory; Pogorelc, Patsy; George, Nicholas; Han, Katherine S.

    2017-01-01

    NASA has accepted two of the 3rd generation Tracking and Data Relay Satellites, TDRS K, L, and M, designed and built by Boeing Defense, Space & Security (DSS). TDRS K, L, and M provide S-band Multiple Access (MA) service and S-band, Ku-band and Ka-band Single Access (SA) services to near Earth orbiting satellites. The TDRS KLM satellites offer improved services relative to the 1st generation TDRS spacecraft, such as: an enhanced MA service featuring increased EIRPs and G/T; and Ka-band SA capability which provides a 225 and 650 MHz return service (customer-to-TDRS direction) bandwidth and a 50 MHz forward service (TDRS-to-customer direction) bandwidth. MA services are provided through a 15 element forward phased array that forms up to two beams with onboard active beamforming and a 32 element return phased array supported by ground-based beamforming. SA services are provided through two 4.6m tri-band reflector antennas which support program track pointing and autotrack pointing. Prior to NASAs acceptance of the satellites, payload on-orbit testing was performed on each satellite to determine on-orbit compliance with design requirements. Performance parameters evaluated include: EIRP, G/T, antenna gain patterns, SA antenna autotrack performance, and radiometric tracking performance. On-orbit antenna calibration and pointing optimization was also performed on the MA and SA antennas including 24 hour duration tests to characterize and calibrate out diurnal effects. Bit-Error-Rate (BER) tests were performed to evaluate the end-to-end link BER performance of service through a TDRS K and L spacecraft. The TDRS M is planned to be launched in August 2017. This paper summarizes the results of the TDRS KL communications payload on-orbit performance verification and end-to-end service characterization and compares the results with the performance of the 2nd generation TDRS J. The paper also provides a high-level overview of an optical communications application that will augment the data rates supported by the Space Network.

  10. Investigating radial wire array Z pinches as a compact x-ray source on the Saturn generator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ampleford, David J.; Bland, S. N.; Jennings, Christopher A.

    2015-08-27

    Radial wire array z pinches, where wires are positioned radially outward from a central cathode to a concentric anode, can act as a compact bright x-ray source that could potentially be used to drive a hohlraum. Experiments were performed on the 7-MA Saturn generator using radial wire arrays. These experiments studied a number of potential risks in scaling radial wire arrays up from the 1-MA level, where they have been shown to be a promising compact X-ray source. Data indicates that at 7 MA, radial wire arrays can radiate ~9 TW with 10-ns full-width at half-maximum from a compact pinch.

  11. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  12. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  13. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  14. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  15. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  16. Demand access communications for TDRSS users

    NASA Technical Reports Server (NTRS)

    Zillig, David; Weinberg, Aaron; Mcomber, Robert

    1994-01-01

    The Tracking and Data Relay Satellite System (TDRSS) has long been used to provide reliable low and high-data rate relay services between user spacecraft in Earth orbit and the ground. To date, these TDRSS services have been implemented via prior scheduling based upon estimates of user needs and mission event timelines. While this approach may be necessary for large users that require greater amounts of TDRSS resources, TDRSS can potentially offer the planned community of smaller science missions (e.g., the small explorer missions), and other emerging users, the unique opportunity for services on demand. In particular, innovative application of the existing TDRSS Multiple Access (MA) subsystem, with its phased array antenna, could be used to implement true demand access services without modification to either the TDRSS satellites or the user transponder, thereby introducing operational and performance benefits to both the user community and the Space Network. In this paper, candidate implementations of demand access service via the TDRSS MA subsystem are examined in detail. Both forward and return link services are addressed and a combination of qualitative and quantitative assessments are provided. The paper also identifies further areas for investigation in this ongoing activity that is being conducted by GSFC/Code 531 under the NASA Code O Advanced Systems Program.

  17. In situ formation of a ZnO/ZnSe nanonail array as a photoelectrode for enhanced photoelectrochemical water oxidation performance

    NASA Astrophysics Data System (ADS)

    Wang, Liyang; Tian, Guohui; Chen, Yajie; Xiao, Yuting; Fu, Honggang

    2016-04-01

    In this study, a ZnO/ZnSe nanonail array was prepared via a two-step sequential hydrothermal synthetic route. In this synthetic process, the ZnO nanorod array was first grown on a fluorine-doped tin oxide (FTO) substrate using a seed-mediated growth approach via the hydrothermal process. Then, the ZnO nanonail array was obtained via in situ growth of ZnSe nano caps onto the ZnO nanorod array via a hydrothermal process in the presence of a Se source. The surface morphology and amount of ZnSe grown on the surface of the ZnO nanorods can be regulated by varying the reaction time and reactant concentration. Compared with pure ZnO nanorods, this unique nanonail array heterostructure exhibits enhanced visible light absorption. The transient photocurrent condition, in combination with steady-state and time-resolved photoluminescence spectroscopy, reveals that the ZnO/ZnSe nanonail array electrode has the highest charge separation rate, highest electron injection efficiency, and highest chemical stability. The photocurrent density of the ZnO/ZnSe nanonail array heterostructure reaches 1.01 mA cm-2 at an applied potential of 0.1 V (vs. Ag/AgCl), which is much higher than that of the ZnO/ZnSe nanorod array (0.71 mA cm-2), the pristine ZnO nanorod array (0.39 mA cm-2), and the ZnSe electrode (0.21 mA cm-2), indicating its significant visible light driven activities for photoelectrochemical water oxidation. This unique morphology of nail-capped nanorods might be important for providing better insight into the correlation between heterostructure and photoelectrochemical activity.In this study, a ZnO/ZnSe nanonail array was prepared via a two-step sequential hydrothermal synthetic route. In this synthetic process, the ZnO nanorod array was first grown on a fluorine-doped tin oxide (FTO) substrate using a seed-mediated growth approach via the hydrothermal process. Then, the ZnO nanonail array was obtained via in situ growth of ZnSe nano caps onto the ZnO nanorod array via a hydrothermal process in the presence of a Se source. The surface morphology and amount of ZnSe grown on the surface of the ZnO nanorods can be regulated by varying the reaction time and reactant concentration. Compared with pure ZnO nanorods, this unique nanonail array heterostructure exhibits enhanced visible light absorption. The transient photocurrent condition, in combination with steady-state and time-resolved photoluminescence spectroscopy, reveals that the ZnO/ZnSe nanonail array electrode has the highest charge separation rate, highest electron injection efficiency, and highest chemical stability. The photocurrent density of the ZnO/ZnSe nanonail array heterostructure reaches 1.01 mA cm-2 at an applied potential of 0.1 V (vs. Ag/AgCl), which is much higher than that of the ZnO/ZnSe nanorod array (0.71 mA cm-2), the pristine ZnO nanorod array (0.39 mA cm-2), and the ZnSe electrode (0.21 mA cm-2), indicating its significant visible light driven activities for photoelectrochemical water oxidation. This unique morphology of nail-capped nanorods might be important for providing better insight into the correlation between heterostructure and photoelectrochemical activity. Electronic supplementary information (ESI) available: SEM, EDS, XPS and photocurrent test. See DOI: 10.1039/c6nr01969b

  18. Multidimensional Normalization to Minimize Plate Effects of Suspension Bead Array Data.

    PubMed

    Hong, Mun-Gwan; Lee, Woojoo; Nilsson, Peter; Pawitan, Yudi; Schwenk, Jochen M

    2016-10-07

    Enhanced by the growing number of biobanks, biomarker studies can now be performed with reasonable statistical power by using large sets of samples. Antibody-based proteomics by means of suspension bead arrays offers one attractive approach to analyze serum, plasma, or CSF samples for such studies in microtiter plates. To expand measurements beyond single batches, with either 96 or 384 samples per plate, suitable normalization methods are required to minimize the variation between plates. Here we propose two normalization approaches utilizing MA coordinates. The multidimensional MA (multi-MA) and MA-loess both consider all samples of a microtiter plate per suspension bead array assay and thus do not require any external reference samples. We demonstrate the performance of the two MA normalization methods with data obtained from the analysis of 384 samples including both serum and plasma. Samples were randomized across 96-well sample plates, processed, and analyzed in assay plates, respectively. Using principal component analysis (PCA), we could show that plate-wise clusters found in the first two components were eliminated by multi-MA normalization as compared with other normalization methods. Furthermore, we studied the correlation profiles between random pairs of antibodies and found that both MA normalization methods substantially reduced the inflated correlation introduced by plate effects. Normalization approaches using multi-MA and MA-loess minimized batch effects arising from the analysis of several assay plates with antibody suspension bead arrays. In a simulated biomarker study, multi-MA restored associations lost due to plate effects. Our normalization approaches, which are available as R package MDimNormn, could also be useful in studies using other types of high-throughput assay data.

  19. Experimental demonstration of monolithically integrated 16 channel DFB laser array fabricated by nanoimprint lithography with AWG multiplexer and SOA for WDM-PON application

    NASA Astrophysics Data System (ADS)

    Zhao, Jianyi; Chen, Xin; Zhou, Ning; Huang, Xiaodong; Cao, Mingde; Wang, Lei; Liu, Wen

    2015-03-01

    A 16-channel monolithically integrated distributed feedback (DFB) laser array with arrayed waveguide gratings (AWGs) multiplexer and semiconductor optical amplifier (SOA) has been fabricated using nanoimprint technology. Selective lasing wavelength with 200 GHz frequency space has been obtained. The typical threshold current is between 20 mA and 30 mA. The output power is higher than 1 mW with 350 mA current in SOA. The side mode suppression ratio (SMSR) of the spectrum is better than 40 dB.

  20. Template-free synthesis of vanadium oxides nanobelt arrays as high-rate cathode materials for lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Qin, Mulan; Liang, Qiang; Pan, Anqiang; Liang, Shuquan; Zhang, Qing; Tang, Yan; Tan, Xiaoping

    2014-12-01

    A facile hydrothermal route has been developed to fabricate the metastable VO2 (B) ultra-thin nanobelt arrays, which can be converted into V2O5 porous nanobelt arrays after calcinating VO2 (B) in air at 400 °C for 1 h. The influence of hydrothermal time to the crystallinity and morphology of the VO2 phase has been studied. A possible mechanism for the formation of VO2 nanobelt arrays has been proposed in this paper. As a cathode material for lithium ion batteries, the V2O5 nanobelt arrays show excellent rate capability and cycling stability. An initial discharge capacity of 142 mA h g-1 can be delivered at a current density of 50 mA g-1 with almost no capacity fading after 100 cycles. Even at a current density of 1000 mA g-1, they still exhibit the capacity of 130 mA h g-1 and superior capacity retention capability. The excellent electrochemical properties are attributed to the ultra-thin thickness and the porous structures of the nanobelts.

  1. Fabrication of hierarchical CoP nanosheet@microwire arrays via space-confined phosphidation toward high-efficiency water oxidation electrocatalysis under alkaline conditions.

    PubMed

    Ji, Xuqiang; Zhang, Rong; Shi, Xifeng; Asiri, Abdullah M; Zheng, Baozhan; Sun, Xuping

    2018-05-03

    In spite of recent advances in the synthesis of transition metal phosphide nanostructures, the simple fabrication of hierarchical arrays with more accessible active sites still remains a great challenge. In this Communication, we report a space-confined phosphidation strategy toward developing hierarchical CoP nanosheet@microwire arrays on nickel foam (CoP NS@MW/NF) using a Co(H2PO4)2·2H3PO4 microwire array as the precursor. The thermally stable nature of the anion in the precursor is key to hierarchical nanostructure formation. When used as a 3D electrode for water oxidation electrocatalysis, such CoP NS@MW/NF needs an overpotential as low as 296 mV to drive a geometrical catalytic current density of 100 mA cm-2 in 1.0 M KOH, outperforming all reported Co phosphide catalysts in alkaline media. This catalyst also shows superior long-term electrochemical durability, maintaining its activity for at least 65 h. This study offers us a general method for facile preparation of hierarchical arrays for applications.

  2. Electronic and Morphological Dual Modulation of Cobalt Carbonate Hydroxides by Mn Doping toward Highly Efficient and Stable Bifunctional Electrocatalysts for Overall Water Splitting.

    PubMed

    Tang, Tang; Jiang, Wen-Jie; Niu, Shuai; Liu, Ning; Luo, Hao; Chen, Yu-Yun; Jin, Shi-Feng; Gao, Feng; Wan, Li-Jun; Hu, Jin-Song

    2017-06-21

    Developing bifunctional efficient and durable non-noble electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is highly desirable and challenging for overall water splitting. Herein, Co-Mn carbonate hydroxide (CoMnCH) nanosheet arrays with controllable morphology and composition were developed on nickel foam (NF) as such a bifunctional electrocatalyst. It is discovered that Mn doping in CoCH can simultaneously modulate the nanosheet morphology to significantly increase the electrochemical active surface area for exposing more accessible active sites and tune the electronic structure of Co center to effectively boost its intrinsic activity. As a result, the optimized Co 1 Mn 1 CH/NF electrode exhibits unprecedented OER activity with an ultralow overpotential of 294 mV at 30 mA cm -2 , compared with all reported metal carbonate hydroxides. Benefited from 3D open nanosheet array topographic structure with tight contact between nanosheets and NF, it is able to deliver a high and stable current density of 1000 mA cm -2 at only an overpotential of 462 mV with no interference from high-flux oxygen evolution. Despite no reports about effective HER on metal carbonate hydroxides yet, the small overpotential of 180 mV at 10 mA cm -2 for HER can be also achieved on Co 1 Mn 1 CH/NF by the dual modulation of Mn doping. This offers a two-electrode electrolyzer using bifunctional Co 1 Mn 1 CH/NF as both anode and cathode to perform stable overall water splitting with a cell voltage of only 1.68 V at 10 mA cm -2 . These findings may open up opportunities to explore other multimetal carbonate hydroxides as practical bifunctional electrocatalysts for scale-up water electrolysis.

  3. Tectonic Evolution of the Izmir Ankara Suture Zone in Northwest Turkey Using Zircon U-Pb Geochronology and Zircon Lu-Hf Isotopic Tracers

    NASA Astrophysics Data System (ADS)

    Campbell, C.; Taylor, M. H.; Licht, A.; Mueller, M.; Ocakglu, F.; Moeller, A.; Metais, G.; Beard, K. C.

    2017-12-01

    Detrital zircons from a Cretaceous forearc basin and Tertiary foreland basin located along the Sakarya Zone of the Western Pontides were analyzed to better understand the closure history of the Tethyan oceans. The Variscan Orogeny is characterized by abundant 350-300 Ma U-Pb ages and vertical ɛHf arrays, consistent with a mature magmatic arc that emplaced plutons through a southward growing accretionary margin. An ɛHf pull-up is observed from 300-250 Ma interpreted as rifting of the Intra-Pontide Ocean. The Cimmerian Orogeny is characterized by a 250-230 Ma ɛHf pull-down, followed by a 230-200 Ma magmatic gap consistent with underthrusting of the Karakaya Complex. From 200-120 Ma another magmatic lull is observed. The Alpine Orogeny is characterized by an ɛHf pull-down from 120-85 Ma within Cretaceous forearc sediments and a 100 Ma deviant ɛHf vertical array within Tertiary foreland basin sediments. Minor zircon U-Pb age peaks and contrasting inter-basinal ɛHf evolution are interpreted to represent onset of Andean-style subduction along the southern margin of the Sakarya Zone at 120 Ma followed by crustal thickening until 85 Ma. The deviant 100 Ma ɛHf vertical array within foreland basin detritus is interpreted as initiation of intra-oceanic subduction within the Izmir-Ankara Ocean. An 85-75 Ma ɛHf pull-up from forearc basin sediments is interpreted as slab roll-back along the southern margin of the Sakarya Zone, responsible for final rifting of the Western Black Sea. At 80 Ma, a vertical ɛHf array from Tertiary foreland basin deposits is interpreted to represent synchronous melting of the Tavsanli Zone and intra-oceanic slab break-off. A single 66 Myr pre-collisional grain defines a sharp ɛHf pull-down immediately prior to total arc shut-off, interpreted to represent incipient collision between the Sakarya and Tavsanli zones. A 52 Ma syn-collisional tuff yields minimally intermediate ɛHf values followed by a slight 48 Ma ɛHf pull-down, interpreted as a second episode of slab break-off followed by crustal thickening, a result of renewed underthrusting.

  4. 42 CFR 422.112 - Access to services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... services. (a) Rules for coordinated care plans. An MA organization that offers an MA coordinated care plan may specify the networks of providers from whom enrollees may obtain services if the MA organization... Medicare enrollee, are available and accessible under the plan. To accomplish this, the MA organization...

  5. Extended Monopole antenna Array with individual Shield (EMAS) coil: An improved monopole antenna design for brain imaging at 7 tesla MRI.

    PubMed

    Woo, Myung-Kyun; Hong, Suk-Min; Lee, Jongho; Kang, Chang-Ki; Park, Sung-Yeon; Son, Young-Don; Kim, Young-Bo; Cho, Zang-Hee

    2016-06-01

    To propose a new Extended Monopole antenna Array with individual Shields (EMAS) coil that improves the B1 field coverage and uniformity along the z-direction. To increase the spatial coverage of Monopole antenna Array (MA) coil, each monopole antenna was shielded and extended in length. Performance of this new coil, which is referred to as EMAS coil, was compared with the original MA coil and an Extended Monopole antenna Array coil with no shield (EMA). For comparison, flip angle, signal-to-noise ratio (SNR), and receive sensitivity maps were measured at multiple regions of interest (ROIs) in the brain. The EMAS coil demonstrated substantially larger flip angle and receive sensitivity than the MA and EMA coils in the inferior aspect of the brain. In the brainstem ROI, for example, the flip angle in the EMAS coil was increased by 45.5% (or 60.0%) and the receive sensitivity was increased by 26.9% (or 14.9%), resulting in an SNR gain of 84.8% (or 76.3%) when compared with the MA coil (or EMA). The EMAS coil provided 25.7% (or 24.4%) more uniform B1+ field distribution compared with the MA (or EMA) coil in sagittal. The EMAS coil successfully extended the imaging volume in lower part of the brain. Magn Reson Med 75:2566-2572, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  6. Full-band TDM-OPDMA for OBI-reduced simultaneous multiple access in a single-wavelength optical access network.

    PubMed

    Jung, Sun-Young; Kim, Chang-Hun; Han, Sang-Kook

    2018-05-14

    Simultaneous multiple access (MA) within a single wavelength can increase the data rate and split ratio in a passive optical network while optical beat interference (OBI) becomes serious in the uplink. Previous techniques to reduce OBI were limited by their complexity and lack of extendibility; as well, bandwidth allocation among MA signals is needed for single photo diode (PD) detection. We proposed and experimentally demonstrated full-band optical pulse division multiplexing-based MA (OPDMA) in an optical access network, which can effectively reduce OBI with extendibility and fully utilize frequency resources of optical modulator without bandwidth allocation in a single-wavelength MA.

  7. Dynamics of conical wire array Z-pinch implosions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ampleford, D. J.; Lebedev, S. V.; Bland, S. N.

    2007-10-15

    A modification of the wire array Z pinch, the conical wire array, has applications to the understanding of wire array implosions and potentially to pulse shaping relevant to inertial confinement fusion. Results are presented from imploding conical wire array experiments performed on university scale 1 MA generators--the MAGPIE generator (1 MA, 240 ns) at Imperial College London [I. H. Mitchell et al., Rev. Sci Instrum. 67, 1533 (1996)] and the Nevada Terawatt Facility's Zebra generator (1 MA, 100 ns) at the University of Nevada, Reno [B. Bauer et al., in Dense Z-Pinches, edited by N. Pereira, J. Davis, and P.more » Pulsifer (AIP, New York, 1997), Vol. 409, p. 153]. This paper will discuss the implosion dynamics of conical wire arrays. Data indicate that mass ablation from the wires in this complex system can be reproduced with a rocket model with fixed ablation velocity. Modulations in the ablated plasma are present, the wavelength of which is invariant to a threefold variation in magnetic field strength. The axial variation in the array leads to a zippered precursor column formation. An initial implosion of a magnetic bubble near the cathode is followed by the implosion zippering upwards. Spectroscopic data demonstrating a variation of plasma parameters (e.g., electron temperature) along the Z-pinch axis is discussed, and experimental data are compared to magnetohydrodynamic simulations.« less

  8. Nine-channel wavelength tunable single mode laser array based on slots.

    PubMed

    Guo, Wei-Hua; Lu, Qiaoyin; Nawrocka, Marta; Abdullaev, Azat; O'Callaghan, James; Donegan, John F

    2013-04-22

    A 9-channel wavelength tunable single-mode laser array based on slots is presented. The fabricated laser array demonstrated a threshold current in a range of 19~21 mA with the SOA unbiased at 20°C under continuous wave condition. Stable single mode performances have been observed with side-mode suppression-ratio (SMSR) > 50 dB. The output power higher than 37 mW was obtained at the SOA injected current of 70 mA for all the 9 channels within the laser array. A wavelength quasi-continuous tuning range of about 27 nm has been achieved for the laser array with the temperature variations from 10°C to 45°C. This array platform is of a single growth and monolithically integrable. It can be easily fabricated by standard photolithography. In addition, it potentially removes the yield problem due to the uncertainty of the facet cleaving.

  9. Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular matrix.

    PubMed

    Ma, Yufei; Ji, Yuan; Huang, Guoyou; Ling, Kai; Zhang, Xiaohui; Xu, Feng

    2015-12-22

    Periodontitis is an inflammatory disease negatively affecting up to 15% of adults worldwide. Periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue regeneration, where it is necessary to find proper extracellular matrix (ECM) materials (e.g., composition, concentration). In this study, we proposed a bioprinting-based approach to generate nano-liter sized three-dimensional (3D) cell-laden hydrogel array with gradient of ECM components, through controlling the volume ratio of two hydrogels, such as gelatin methacrylate (GelMA) and poly(ethylene glycol) (PEG) dimethacrylate. The resulting cell-laden array with a gradient of GelMA/PEG composition was used to screen human PDLSC response to ECM. The behavior (e.g., cell viability, spreading) of human PDLSCs in GelMA/PEG array were found to be depended on the volume ratios of GelMA/PEG, with cell viability and spreading area decreased along with increasing the ratio of PEG. The developed approach would be useful for screening cell-biomaterial interaction in 3D and promoting regeneration of functional tissue.

  10. A 16-Channel Distributed-Feedback Laser Array with a Monolithic Integrated Arrayed Waveguide Grating Multiplexer for a Wavelength Division Multiplex-Passive Optical Network System Network

    NASA Astrophysics Data System (ADS)

    Zhao, Jian-Yi; Chen, Xin; Zhou, Ning; Huang, Xiao-Dong; Cao, Ming-De; Liu, Wen

    2014-07-01

    A 16-channel distributed-feedback (DFB) laser array with a monolithic integrated arrayed waveguide grating multiplexer for a wavelength division multiplex-passive optical network system is fabricated by using the butt-joint metal organic chemical vapor deposition technology and nanoimpirnt technology. The results show that the threshold current is about 20-30 mA at 25°C. The DFB laser side output power is about 16 mW with a 150 mA injection current. The lasing wavelength is from 1550 nm to 1575 nm covering a more than 25 nm range with 200 GHz channel space. A more than 55 dB sidemode suppression ratio is obtained.

  11. Thermal management and light extraction in multi-chip and high-voltage LEDs by cup-shaped copper heat spreader technology

    NASA Astrophysics Data System (ADS)

    Horng, Ray-Hua; Hu, Hung-Lieh; Tang, Li-Shen; Ou, Sin-Liang

    2013-03-01

    For LEDs with original structure and copper heat spreader, the highest surface temperatures of 3×3 array LEDs modules were 52.6 and 42.67 °C (with 1050 mA injection current), while the highest surface temperatures of 4×4 array LEDs modules were 58.55 and 48.85 °C (with 1400 mA injection current), respectively. As the 5×5 array LEDs modules with original structure and copper heat spreader were fabricated, the highest surface temperatures at 1750 mA injection current were 68.51 and 56.73 °C, respectively. The thermal resistance of optimal LEDs array module with copper heat spreader on heat sink using compound solder is reduced obviously. On the other hand, the output powers of 3×3, 4×4 and 5×5 array LEDs modules with original structure were 3621.7, 6346.3 and 9760.4 mW at injection currents of 1050, 1400 and 1750 mA, respectively. Meanwhile, the output powers of these samples with copper heat spreader can be improved to 4098.5, 7150.3 and 10919.6 mW, respectively. The optical and thermal characteristics of array LEDs module have been improved significantly using the cup-shaped copper structure. Furthermore, various types of epoxy-packaged LEDs with cup-shaped structure were also fabricated. It is found that the light extraction efficiency of LED with semicircle package has 55% improvement as compared to that of LED with flat package. The cup-shaped copper structure was contacted directly with sapphire to enhance heat dissipation. In addition to efficient heat dissipation, the light extraction of the lateral emitting in high-power LEDs can be improved.

  12. Methamphetamine drinking microstructure in mice bred to drink high or low amounts of methamphetamine

    PubMed Central

    Eastwood, Emily C.; Barkley-Levenson, Amanda M.; Phillips, Tamara J.

    2014-01-01

    Genetic factors likely influence individual sensitivity to positive and negative effects of methamphetamine (MA) and risk for MA dependence. Genetic influence on MA consumption has been confirmed by selectively breeding mouse lines to consume high (MAHDR) or low (MALDR) amounts of MA, using a two-bottle choice MA drinking (MADR) procedure. Here, we employed a lickometer system to characterize the microstructure of MA (20, 40, and 80 mg/l) and water intake in MAHDR and MALDR mice in 4-h limited access sessions, during the initial 4 hours of the dark phase of their 12:12 h light:dark cycle. Licks at one-minute intervals and total volume consumed were recorded, and bout analysis was performed. MAHDR and MALDR mice consumed similar amounts of MA in mg/kg on the first day of access, but MAHDR mice consumed significantly more MA than MALDR mice during all subsequent sessions. The higher MA intake of MAHDR mice was associated with a larger number of MA bouts, longer bout duration, shorter interbout interval, and shorter latency to the first bout. In a separate 4-h limited access MA drinking study, MALDR and MAHDR mice had similar blood MA levels on the first day MA was offered, but MAHDR mice had higher blood MA levels on all subsequent days, which corresponded with MA intake. These data provide insight into the microstructure of MA intake in an animal model of differential genetic risk for MA consumption, which may be pertinent to MA use patterns relevant to genetic risk for MA dependence. PMID:24978098

  13. Pharmaceutical Market Access: current state of affairs and key challenges - results of the Market Access Launch Excellence Inventory (MALEI).

    PubMed

    Koch, Marcus A

    2015-01-01

    To take inventory of the current state of affairs of Market Access Launch Excellence in the life sciences industry. To identify key gaps and challenges for Market Access (MA) and discuss how they can be addressed. To generate a baseline for benchmarking MA launch excellence. An online survey was conducted with pharmaceutical executives primarily working in MA, marketing, or general management. The survey aimed to evaluate MA excellence prerequisites across the product life cycle (rated by importance and level of implementation) and to describe MA activity models in the respective companies. Composite scores were calculated from respondents' ratings and answers. Implementation levels of MA excellence prerequisites generally lagged behind their perceived importance. Item importance and the respective level of implementation correlated well, which can be interpreted as proof of the validity of the questionnaire. The following areas were shown to be particularly underimplemented: 1) early integration of MA and health economic considerations in research and development decision making, 2) developing true partnerships with payers, including the development of services 'beyond the pill', and 3) consideration of human resource and talent management. The concept of importance-adjusted implementation levels as a hybrid parameter was introduced and shown to be a viable tool for benchmarking purposes. More than 70% of respondents indicated that their companies will invest broadly in MA in terms of capital and headcount within the next 3 years. MA (launch) excellence needs to be further developed in order to close implementation gaps across the entire product life cycle. As MA is a comparatively young pharmaceutical discipline in a complex and dynamic environment, this effort will require strategic focus and dedication. The Market Access Launch Excellence Inventory benchmarking tool may help guide decision makers to prioritize their endeavors.

  14. 3D MHD Simulations of Radial Wire Array Z-pinches

    NASA Astrophysics Data System (ADS)

    Niasse, N.; Chittenden, J. P.; Bland, S. N.; Suzuki-Vidal, F. A.; Hall, G. N.; Lebedev, S. V.; Calamy, H.; Zucchini, F.; Lassalle, F.; Bedoch, J. P.

    2009-01-01

    Recent experiments carried out on the MAGPIE (1 MA, 250 ns), OEDIPE (730 kA, 1.5 μs) and SPHINX (4 MA, 700 ns)[1] facilities have shown the relatively high level of scalability of the Radial Wire Array Z-pinches. These configurations where the wires stretch radially outwards from a central cathode offer numerous advantages over standard cylindrical arrays. In particular, imploding in a very stable and compact way, they seem suitable for coupling to small scale hohlraums. Making use of the 3D resistive magneto-hydrodynamic code GORGON[2] developed at Imperial College, the dynamic of the radial wire arrays is investigated. Influence of the cathode hotspots and wires angle on the x-ray emissions is also discussed. Comparison with experiments is offered to validate the numerical studies.

  15. Intensity dynamics in a waveguide array laser

    NASA Astrophysics Data System (ADS)

    Feng, Mingming; Williams, Matthew O.; Kutz, J. Nathan; Silverman, Kevin L.; Mirin, Richard P.; Cundiff, Steven T.

    2011-02-01

    We consider experimentally and theoretically the optical field dynamics of a five-emitter laser array subject to a ramped injection current. We have achieved experimentally an array that produces a robust oscillatory power output with a nearly constant π phase shift between the oscillations from each waveguide. The output power also decreases linearly as a function of waveguide number. Those behaviors persisted for pump currents varying between 380 and 500 mA with only a slight change in phase. Of note is the fact that the fundamental frequency of oscillation increases with injection current, and higher harmonics are produced above a threshold current of approximately 380 mA. Experimental observations and theoretical predictions are in agreement. A low dimensional model was also developed and the impact of the nonuniform injection current studied. A nonuniform injection current is capable of shifting the bifurcations of the waveguide array providing a valuable method of array tuning without additional gain or structural alterations to the array.

  16. Multiple Access Schemes for Lunar Missions

    NASA Technical Reports Server (NTRS)

    Deutsch, Leslie; Hamkins, Jon; Stocklin, Frank J.

    2010-01-01

    Two years ago, the NASA Coding, Modulation, and Link Protocol (CMLP) study was completed. The study, led by the authors of this paper, recommended codes, modulation schemes, and desired attributes of link protocols for all space communication links in NASA's future space architecture. Portions of the NASA CMLP team were reassembled to resolve one open issue: the use of multiple access (MA) communication from the lunar surface. The CMLP-MA team analyzed and simulated two candidate multiple access schemes that were identified in the original CMLP study: Code Division MA (CDMA) and Frequency Division MA (FDMA) based on a bandwidth-efficient Continuous Phase Modulation (CPM) with a superimposed Pseudo-Noise (PN) ranging signal (CPM/PN). This paper summarizes the results of the analysis and simulation of the CMLP-MA study and describes the final recommendations.

  17. Investigation of ablation of thin foil aluminum ribbon array at 1.5 MA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ye, Fan, E-mail: yefan1931@126.com; Li, Zhenghong; Chen, Faxin

    We present experimental studies of initiation and ablation of a thin foil aluminum ribbon array at the 1.5 MA current level. In contrast to the previous work, we employ ribbon arrays with different ribbon gap parameters to investigate how this affects plasma initiation and foil ablation. Gated narrowband ultraviolet imaging indicated that the current was disorderly distributed at early period of discharge. But later on, it became axially stable and azimuthally symmetrical even for load with a gap as small as 0.1 mm. Using magnetic field probes installed inside and outside the array, we also observed that precursor current at positionsmore » with a distance of less than 2.7 mm to the central axis for 4-mm-radius arrays decreased when ribbon gap became small. Results of 0.2 mm gap ribbon array showed an evidence that ribbons can be merged. These observations imply that thin foil ribbon arrays may have potential applications in z-pinch experiments on large scale pulsed power facilities.« less

  18. Gold ultra-microelectrode arrays: application to the steady-state voltammetry of hydroxide ion in aqueous solution.

    PubMed

    Ordeig, Olga; Banks, Craig E; Davies, Trevor J; del Campo, F Javier; Muñoz, Francesc Xavier; Compton, Richard G

    2006-05-01

    Gold ultra-microelectrode arrays are used to explore the electrochemical oxidation of hydroxide ions and are shown to be analytical useful. Two types of ultra-microelectrode arrays are used; the first consist of 256 individual electrodes of 5 microm in radius, 170 of which are electrochemically active in a cubic arrangement which are separated from their nearest neighbour by a distance of 100 microm. The second array compromises 2597 electrodes of 2.5 microm in radius and of which 1550 of which are electrochemically active in a hexagonal arrangement separated by the nearest neighbour by 55 microm. Well defined voltammetric waves are found with peak currents proportional to the concentration of hydroxide ions in the range 50 microM to 1 mM. Detection limits of 20 microM using the 170 ultra-microelectrode and 10 microM with the 1550 ultra-microelectrode array are shown to be possible but with a higher sensitivity of 4 mA M(-1) observed using the 1550 ultra-microelectrode array compared to 1.2 mA M(-1) with the 170 ultra-microelectrode array.

  19. Observation of >400-eV precursor plasmas from low-wire-number copper arrays at the 1-MA zebra facility.

    PubMed

    Coverdale, C A; Safronova, A S; Kantsyrev, V L; Ouart, N D; Esaulov, A A; Deeney, C; Williamson, K M; Osborne, G C; Shrestha, I; Ampleford, D J; Jones, B

    2009-04-17

    Experiments with cylindrical copper wire arrays at the 1-MA Zebra facility show that high temperatures exist in the precursor plasmas formed when ablated wire array material accretes on the axis prior to the stagnation of a z pinch. In these experiments, the precursor radiated approximately 20% of the >1000 eV x-ray output, and time-resolved spectra show substantial emission from Cu L-shell lines. Modeling of the spectra shows an increase in temperature as the precursor forms, up to approximately 450 eV, after which the temperature decreases to approximately 220-320 eV until the main implosion.

  20. Pharmaceutical Market Access: current state of affairs and key challenges – results of the Market Access Launch Excellence Inventory (MALEI)

    PubMed Central

    Koch, Marcus A.

    2015-01-01

    Objectives To take inventory of the current state of affairs of Market Access Launch Excellence in the life sciences industry. To identify key gaps and challenges for Market Access (MA) and discuss how they can be addressed. To generate a baseline for benchmarking MA launch excellence. Methodology An online survey was conducted with pharmaceutical executives primarily working in MA, marketing, or general management. The survey aimed to evaluate MA excellence prerequisites across the product life cycle (rated by importance and level of implementation) and to describe MA activity models in the respective companies. Composite scores were calculated from respondents’ ratings and answers. Results Implementation levels of MA excellence prerequisites generally lagged behind their perceived importance. Item importance and the respective level of implementation correlated well, which can be interpreted as proof of the validity of the questionnaire. The following areas were shown to be particularly underimplemented: 1) early integration of MA and health economic considerations in research and development decision making, 2) developing true partnerships with payers, including the development of services ‘beyond the pill’, and 3) consideration of human resource and talent management. The concept of importance-adjusted implementation levels as a hybrid parameter was introduced and shown to be a viable tool for benchmarking purposes. More than 70% of respondents indicated that their companies will invest broadly in MA in terms of capital and headcount within the next 3 years. Conclusions MA (launch) excellence needs to be further developed in order to close implementation gaps across the entire product life cycle. As MA is a comparatively young pharmaceutical discipline in a complex and dynamic environment, this effort will require strategic focus and dedication. The Market Access Launch Excellence Inventory benchmarking tool may help guide decision makers to prioritize their endeavors. PMID:29785250

  1. 1.55 µm high speed low chirp electroabsorption modulated laser arrays based on SAG scheme.

    PubMed

    Cheng, Yuanbing; Wang, Qi Jie; Pan, Jiaoqing

    2014-12-15

    We demonstrate a cost-effective 1.55 µm low chirp 4 × 25 Gbit/s electroabsorption modulated laser (EML) array with 0.8 nm channel spacing by varying ridge width of the lasers and using selective area growth (SAG) integration scheme. The devices for all the 4 channels within the EML array show uniform threshold currents around 18 mA and high SMSRs over 45 dB. The output optical power of each channel is about 9 mW at an injection current of 100 mA. The typical chirp value of single EML measured by a fiber resonance method varied from 2.2 to -4 as the bias voltage was increased from 0 V to 2.5 V. These results show that the EML array is a suitable light source for 100 Gbit/s optical transmissions.

  2. Enhancement in photo-electrochemical efficiency by reducing recombination rate in branched TiO2 nanotube array on functionalizing with ZnO micro crystals

    NASA Astrophysics Data System (ADS)

    Boda, Muzaffar Ahmad; Ashraf Shah, Mohammad

    2018-06-01

    In this study, branched TiO2 nanotube array were fabricated through electrochemical anodization process at constant voltage using third generation electrolyte. On account of morphological advantage, these nanotubes shows significant enhancement in photo-electrochemical property than compact or conventional titania nanotube array. However, their photo-electrochemical efficiency intensifies on coating with ZnO micro-crystals. ZnO coated branched TiO2 nanotube array shows a photocurrent density of 27.8 mA cm‑2 which is 1.55 times the photocurrent density (17.2 mA cm‑2) shown by bare branched titania nanotubes. The significant enhancement in photocurrent density shown by the resulting ZnO/TiO2 hybrid structure is attributed to suppression in electron–hole recombination phenomenon by offering smooth pathway to photo generated excitons on account of staggered band edge positions in individual semiconductors.

  3. Electrodeposited three-dimensional Ni-Si nanocable arrays as high performance anodes for lithium ion batteries.

    PubMed

    Liu, Hao; Hu, Liangbin; Meng, Ying Shirley; Li, Quan

    2013-11-07

    A configuration of three-dimensional Ni-Si nanocable array anodes is proposed to overcome the severe volume change problem of Si during the charging-discharging process. In the fabrication process, a simple and low cost electrodeposition is employed to deposit Si instead of the common expansive vapor phase deposition methods. The optimum composite nanocable array electrode achieves a high specific capacity ~1900 mA h g(-1) at 0.05 C. After 100 cycles at 0.5 C, 88% of the initial capacity (~1300 mA h g(-1)) remains, suggesting its good capacity retention ability. The high performance of the composite nanocable electrode is attributed to its excellent adhesion of the active material on the three-dimensional current collector and short ionic/electronic transport pathways during cycling.

  4. Self-supported Zn3P2 nanowire arrays grafted on carbon fabrics as an advanced integrated anode for flexible lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Li, Wenwu; Gan, Lin; Guo, Kai; Ke, Linbo; Wei, Yaqing; Li, Huiqiao; Shen, Guozhen; Zhai, Tianyou

    2016-04-01

    We, for the first time, successfully grafted well-aligned binary lithium-reactive zinc phosphide (Zn3P2) nanowire arrays on carbon fabric cloth by a facile CVD method. When applied as a novel self-supported binder-free anode for lithium ion batteries (LIBs), the hierarchical three-dimensional (3D) integrated anode shows excellent electrochemical performances: a highly reversible initial lithium storage capacity of ca. 1200 mA h g-1 with a coulombic efficiency of up to 88%, a long lifespan of over 200 cycles without obvious decay, and a high rate capability of ca. 400 mA h g-1 capacity retention at an ultrahigh rate of 15 A g-1. More interestingly, a flexible LIB full cell is assembled based on the as-synthesized integrated anode and the commercial LiFePO4 cathode, and shows striking lithium storage performances very close to the half cells: a large reversible capacity over 1000 mA h g-1, a long cycle life of over 200 cycles without obvious decay, and an ultrahigh rate performance of ca. 300 mA h g-1 even at 20 A g-1. Considering the excellent lithium storage performances of coin-type half cells as well as flexible full cells, the as-prepared carbon cloth grafted well-aligned Zn3P2 nanowire arrays would be a promising integrated anode for flexible LIB full cell devices.We, for the first time, successfully grafted well-aligned binary lithium-reactive zinc phosphide (Zn3P2) nanowire arrays on carbon fabric cloth by a facile CVD method. When applied as a novel self-supported binder-free anode for lithium ion batteries (LIBs), the hierarchical three-dimensional (3D) integrated anode shows excellent electrochemical performances: a highly reversible initial lithium storage capacity of ca. 1200 mA h g-1 with a coulombic efficiency of up to 88%, a long lifespan of over 200 cycles without obvious decay, and a high rate capability of ca. 400 mA h g-1 capacity retention at an ultrahigh rate of 15 A g-1. More interestingly, a flexible LIB full cell is assembled based on the as-synthesized integrated anode and the commercial LiFePO4 cathode, and shows striking lithium storage performances very close to the half cells: a large reversible capacity over 1000 mA h g-1, a long cycle life of over 200 cycles without obvious decay, and an ultrahigh rate performance of ca. 300 mA h g-1 even at 20 A g-1. Considering the excellent lithium storage performances of coin-type half cells as well as flexible full cells, the as-prepared carbon cloth grafted well-aligned Zn3P2 nanowire arrays would be a promising integrated anode for flexible LIB full cell devices. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr08467a

  5. Application of Regional Arrays in Seismic Verification Research

    DTIC Science & Technology

    1990-08-31

    Hill, MA 02167 P.O. Box 1620 La Jolla, CA 92038-1620 Dr. Richard LaCoss Prof. William Menke MIT-Lincoln Laboratory L amront-Doherty -- dogical b ser t...LWH of Columbia University Hanscom AFB, MA 01731-5000 Palisades, NY 10964 3 Dr. Lorraine Wolf GLILWH Hanscom AFB, MA 01731-5000 Dr. William Wortman... William J. Best Prof. Robert W. Clayton 907 Westwood Drive Seismological Laboratory Vienna, VA 22180 Division of Geological & Planetary Sciences

  6. Heterogeneous NiCo2O4@polypyrrole core/sheath nanowire arrays on Ni foam for high performance supercapacitors

    NASA Astrophysics Data System (ADS)

    Hu, Jing; Li, Minchan; Lv, Fucong; Yang, Mingyang; Tao, Pengpeng; Tang, Yougen; Liu, Hongtao; Lu, Zhouguang

    2015-10-01

    A novel heterogeneous NiCo2O4@PPy core/sheath nanowire arrays are directly grown on Ni foam involving three facile steps, hydrothermal synthesis and calcination of NiCo2O4 nanowire arrays and subsequent in-situ oxidative polymerization of polypyrrole (PPy). When investigated as binder- and conductive additive-free electrodes for supercapacitors (SCs) in 6 M KOH, the NiCo2O4@PPy core/sheath nanowire arrays exhibit high areal capacitance of 3.49 F cm-2 at a discharge current density of 5 mA cm-2, which is almost 1.5 times as much as the pristine NiCo2O4 (2.30 F cm-2). More importantly, it can remain 3.31 F cm-2 (94.8% retention) after 5000 cycles. The as-obtained electrode also displays excellent rate capability, whose areal capacitance can still remain 2.79 F cm-2 while the discharge current density is increased to 50 mA cm-2. The remarkable electrochemical performance is mainly attributed to the unique heterogeneous core/sheath nanowire-array architectures.

  7. 42 CFR 422.112 - Access to services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Access to services. (a) Rules for coordinated care plans. An MA organization that offers an MA... organization ensures that all covered services, including supplemental services contracted for by (or on behalf... organization must meet the following requirements: (1) Provider network. (i) Maintain and monitor a network of...

  8. 42 CFR 422.112 - Access to services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Access to services. (a) Rules for coordinated care plans. An MA organization that offers an MA... organization ensures that all covered services, including supplemental services contracted for by (or on behalf... organization must meet the following requirements: (1) Provider network. (i) Maintain and monitor a network of...

  9. 42 CFR 422.112 - Access to services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Access to services. (a) Rules for coordinated care plans. An MA organization that offers an MA... organization ensures that all covered services, including supplemental services contracted for by (or on behalf... organization must meet the following requirements: (1) Provider network. (i) Maintain and monitor a network of...

  10. Y-doping TiO2 nanorod arrays for efficient perovskite solar cells

    NASA Astrophysics Data System (ADS)

    Deng, Xinlian; Wang, Yanqing; Cui, Zhendong; Li, Long; Shi, Chengwu

    2018-05-01

    To improve the electron transportation in TiO2 nanorod arrays and charge separation in the interface of TiO2/perovskite, Y-doping TiO2 nanorod arrays with the length of 200 nm, diameter of 11 nm and areal density of 1050 μm-2 were successfully prepared by the hydrothermal method and the influence of Y/Ti molar ratios of 0%, 3%, 5% in the hydrothermal grown solutions on the growth of TiO2 nanorod arrays was investigated. The results revealed that the appropriate Y/Ti molar ratios can increase the areal density of the corresponding TiO2 nanorod arrays and improve the charge separation in the interface of the TiO2/perovskite. The Y-doping TiO2 nanorod array perovskite solar cells with the Y/Ti molar ratio of 3% exhibited a photoelectric conversion efficiency (PCE) of 18.11% along with an open-circuit voltage (Voc) of 1.06 V, short-circuit photocurrent density (Jsc) of 22.50 mA cm-2 and fill factor (FF) of 76.16%, while the un-doping TiO2 nanorod array perovskite solar cells gave a PCE of 16.42% along with Voc of 1.04 V, Jsc of 21.66 mA cm-2 and FF of 72.97%.

  11. Increase in the energy density of the pinch plasma in 3D implosion of quasi-spherical wire arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aleksandrov, V. V., E-mail: alexvv@triniti.ru; Gasilov, V. A.; Grabovski, E. V.

    Results are presented from experimental studies of the characteristics of the soft X-ray (SXR) source formed in the implosion of quasi-spherical arrays made of tungsten wires and metalized kapron fibers. The experiments were carried out at the Angara-5-1 facility at currents of up to 3 MA. Analysis of the spatial distribution of hard X-ray emission with photon energies above 20 keV in the pinch images taken during the implosion of quasi-spherical tungsten wire arrays (QTWAs) showed that a compact quasi-spherical plasma object symmetric with respect to the array axis formed in the central region of the array. Using a diffractionmore » grazing incidence spectrograph, spectra of SXR emission with wavelengths of 20–400 Å from the central, axial, and peripheral regions of the emission source were measured with spatial resolutions along the array radius and height in the implosion of QTWAs. It is shown that the emission spectra of the SXR sources formed under the implosion of quasi-spherical and cylindrical tungsten wire arrays at currents of up to 3 MA have a maximum in the wavelength range of 50–150 Å. It is found that, during the implosion of a QTWA with a profiled linear mass, a redistribution of energy in the emission spectrum takes place, which indicates that, during 3D implosion, the energy of longitudinal motion of the array material additionally contributes to the radiation energy. It is also found that, at close masses of the arrays and close values of the current in the range of 2.4{sup −3} MA, the average energy density in the emission source formed during the implosion of a quasi-spherical wire array is larger by a factor of 7 than in the source formed during the implosion of a cylindrical wire array. The experimental data were compared with results of 3D simulations of plasma dynamics and radiation generation during the implosion of quasi-spherical wire arrays with a profiled mass by using the MARPLE-3D radiative magnetohydrodynamic code, developed at the Keldysh Institute of Applied Mathematics, Russian Academy of Sciences.« less

  12. Conversion of electromagnetic energy in Z-pinch process of single planar wire arrays at 1.5 MA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liangping, Wang; Mo, Li; Juanjuan, Han

    The electromagnetic energy conversion in the Z-pinch process of single planar wire arrays was studied on Qiangguang generator (1.5 MA, 100 ns). Electrical diagnostics were established to monitor the voltage of the cathode-anode gap and the load current for calculating the electromagnetic energy. Lumped-element circuit model of wire arrays was employed to analyze the electromagnetic energy conversion. Inductance as well as resistance of a wire array during the Z-pinch process was also investigated. Experimental data indicate that the electromagnetic energy is mainly converted to magnetic energy and kinetic energy and ohmic heating energy can be neglected before the final stagnation. Themore » kinetic energy can be responsible for the x-ray radiation before the peak power. After the stagnation, the electromagnetic energy coupled by the load continues increasing and the resistance of the load achieves its maximum of 0.6–1.0 Ω in about 10–20 ns.« less

  13. Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice.

    PubMed

    Juárez-Portilla, Claudia; Pitter, Michael; Kim, Rachel D; Patel, Pooja Y; Ledesma, Robert A; LeSauter, Joseph; Silver, Rae

    2018-01-01

    The ability to sense time and anticipate events is critical for survival. Learned responses that allow anticipation of the availability of food or water have been intensively studied. While anticipatory behaviors also occur prior to availability of regularly available rewards, there has been relatively little work on anticipation of drugs of abuse, specifically methamphetamine (MA). In the present study, we used a protocol that avoided possible CNS effects of stresses of handling or surgery by testing anticipation of MA availability in animals living in their home cages, with daily voluntary access to the drug at a fixed time of day. Anticipation was operationalized as the amount of wheel running prior to MA availability. Mice were divided into four groups given access to either nebulized MA or water, in early or late day. Animals with access to MA, but not water controls, showed anticipatory activity, with more anticipation in early compared to late day and significant interaction effects. Next, we explored the neural basis of the MA anticipation, using c-FOS expression, in animals euthanized at the usual time of nebulization access. In the dorsomedial hypothalamus (DMH) and orbitofrontal cortex (OFC), the pattern of c-FOS expression paralleled that of anticipatory behavior, with significant main and interaction effects of treatment and time of day. The results for the lateral septum (LS) were significant for main effects and marginally significant for interaction effects. These studies suggest that anticipation of MA is associated with activation of brain regions important in circadian timing, emotional regulation, and decision making.

  14. Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

    PubMed Central

    Pitter, Michael; Patel, Pooja Y.; Ledesma, Robert A.

    2018-01-01

    The ability to sense time and anticipate events is critical for survival. Learned responses that allow anticipation of the availability of food or water have been intensively studied. While anticipatory behaviors also occur prior to availability of regularly available rewards, there has been relatively little work on anticipation of drugs of abuse, specifically methamphetamine (MA). In the present study, we used a protocol that avoided possible CNS effects of stresses of handling or surgery by testing anticipation of MA availability in animals living in their home cages, with daily voluntary access to the drug at a fixed time of day. Anticipation was operationalized as the amount of wheel running prior to MA availability. Mice were divided into four groups given access to either nebulized MA or water, in early or late day. Animals with access to MA, but not water controls, showed anticipatory activity, with more anticipation in early compared to late day and significant interaction effects. Next, we explored the neural basis of the MA anticipation, using c-FOS expression, in animals euthanized at the usual time of nebulization access. In the dorsomedial hypothalamus (DMH) and orbitofrontal cortex (OFC), the pattern of c-FOS expression paralleled that of anticipatory behavior, with significant main and interaction effects of treatment and time of day. The results for the lateral septum (LS) were significant for main effects and marginally significant for interaction effects. These studies suggest that anticipation of MA is associated with activation of brain regions important in circadian timing, emotional regulation, and decision making. PMID:29632871

  15. Hierarchical core-shell structure of ZnO nanorod@NiO/MoO₂ composite nanosheet arrays for high-performance supercapacitors.

    PubMed

    Hou, Sucheng; Zhang, Guanhua; Zeng, Wei; Zhu, Jian; Gong, Feilong; Li, Feng; Duan, Huigao

    2014-08-27

    A hierarchical core-shell structure of ZnO nanorod@NiO/MoO2 composite nanosheet arrays on nickel foam substrate for high-performance supercapacitors was constructed by a two-step solution-based method involving two hydrothermal processes followed by a calcination treatment. Compared to one composed of pure NiO/MoO2 composite nanosheets, the hierarchical core-shell structure electrode displays better pseudocapacitive behaviors in 2 M KOH, including high areal specific capacitance values of 1.18 F cm(-2) at 5 mA cm(-2) and 0.6 F cm(-2) at 30 mA cm(-2) as well as relatively good rate capability at high current densities. Furthermore, it also shows remarkable cycle stability, remaining at 91.7% of the initial value even after 4000 cycles at a current density of 10 mA cm(-2). The enhanced pseudocapacitive behaviors are mainly due to the unique hierarchical core-shell structure and the synergistic effect of combining ZnO nanorod arrays and NiO/MoO2 composite nanosheets. This novel hierarchical core-shell structure shows promise for use in next-generation supercapacitors.

  16. Self-assembled hybrid polymer-TiO2 nanotube array heterojunction solar cells.

    PubMed

    Shankar, Karthik; Mor, Gopal K; Prakasam, Haripriya E; Varghese, Oomman K; Grimes, Craig A

    2007-11-20

    Films comprised of 4 microm long titanium dioxide nanotube arrays were fabricated by anodizing Ti foils in an ethylene glycol based electrolyte. A carboxylated polythiophene derivative was self-assembled onto the TiO2 nanotube arrays by immersing them in a solution of the polymer. The binding sites of the carboxylate moiety along the polymer chain provide multiple anchoring sites to the substrate, making for a stable rugged film. Backside illuminated liquid junction solar cells based on TiO2 nanotube films sensitized by the self-assembled polymeric layer showed a short-circuit current density of 5.5 mA cm-2, a 0.7 V open circuit potential, and a 0.55 fill factor yielding power conversion efficiencies of 2.1% under AM 1.5 sun. A backside illuminated single heterojunction solid state solar cell using the same self-assembled polymer was demonstrated and yielded a photocurrent density as high as 2.0 mA cm-2. When a double heterojunction was formed by infiltrating a blend of poly(3-hexylthiophene) (P3HT) and C60-methanofullerene into the self-assembled polymer coated nanotube arrays, a photocurrent as high as 6.5 mA cm-2 was obtained under AM 1.5 sun with a corresponding efficiency of 1%. The photocurrent action spectra showed a maximum incident photon-to-electron conversion efficiency (IPCE) of 53% for the liquid junction cells and 25% for the single heterojunction solid state solar cells.

  17. Characterisation of the current switch mechanism in two-stage wire array Z-pinches

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burdiak, G. C.; Lebedev, S. V.; Harvey-Thompson, A. J.

    2015-11-15

    In this paper, we describe the operation of a two-stage wire array z-pinch driven by the 1.4 MA, 240 ns rise-time Magpie pulsed-power device at Imperial College London. In this setup, an inverse wire array acts as a fast current switch, delivering a current pre-pulse into a cylindrical load wire array, before rapidly switching the majority of the generator current into the load after a 100–150 ns dwell time. A detailed analysis of the evolution of the load array during the pre-pulse is presented. Measurements of the load resistivity and energy deposition suggest significant bulk heating of the array mass occurs. Themore » ∼5 kA pre-pulse delivers ∼0.8 J of energy to the load, leaving it in a mixed, predominantly liquid-vapour state. The main current switch occurs as the inverse array begins to explode and plasma expands into the load region. Electrical and imaging diagnostics indicate that the main current switch may evolve in part as a plasma flow switch, driven by the expansion of a magnetic cavity and plasma bubble along the length of the load array. Analysis of implosion trajectories suggests that approximately 1 MA switches into the load in 100 ns, corresponding to a doubling of the generator dI/dt. Potential scaling of the device to higher current machines is discussed.« less

  18. New compact hohlraum configuration research at the 1.7 MA Z-pinch generator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kantsyrev, V. L., E-mail: victor@unr.edu; Shrestha, I. K.; Esaulov, A. A.

    A new compact Z-pinch x-ray hohlraum design with parallel-driven x-ray sources was experimentally demonstrated in a full configuration with a central target and tailored shine shields (to provide a symmetric temperature distribution on the target) at the 1.7 MA Zebra generator. This presentation reports on the joint success of two independent lines of research. One of these was the development of new sources – planar wire arrays (PWAs). PWAs turned out to be a prolific radiator. Another success was the drastic improvement in energy efficiency of pulsed-power systems, such as the Load Current Multiplier (LCM). The Zebra/LCM generator almost doubledmore » the plasma load current to 1.7 MA. The two above-mentioned innovative approaches were used in combination to produce a new compact hohlraum design for ICF, as jointly proposed by SNL and UNR. Good agreement between simulated and measured radiation temperature of the central target is shown. Experimental comparison of PWAs with planar foil liners (PFL) - another viable alternative to wire array loads at multi-MA generators show promising data. Results of research at the University of Nevada Reno allowed for the study of hohlraum coupling physics at University-scale generators. The advantages of new hohlraum design applications for multi-MA facilities with W or Au double PWAs or PFL x-ray sources are discussed.« less

  19. Co3O4 nanowire@NiO nanosheet arrays for high performance asymmetric supercapacitors.

    PubMed

    Xing, Lei; Dong, Yidi; Hu, Fang; Wu, Xiang; Umar, Ahmad

    2018-04-24

    Herein, we report a simple and facile sequential hydrothermal process for the synthesis of Co3O4 nanowire@NiO nanosheet arrays (CNAs). The as-synthesized CNAs were characterized in detail using various analytical techniques, which confirmed the high crystallinity, purity, and high-density growth of these nanomaterials. From an application point of view, the as-synthesized CNAs were directly used as supercapacitor electrodes, revealing a specific capacitance of up to 2018 mF cm-2 at a current density of 2 mA cm-2. Furthermore, a flexible asymmetric supercapacitor was fabricated using the as-synthesized CNAs as the anode and activated carbon as the cathode, which revealed a specific capacitance of 134.6 mF cm-2 at a current density of 2 mA cm-2. In addition, the supercapacitor showed excellent capacity retention of 73.5% after 10 000 cycles at a current density of 10 mA cm-2.

  20. Designs and Plans for MAIZE: a 1 MA LTD-Driven Z-Pinch

    NASA Astrophysics Data System (ADS)

    Gilgenbach, R. M.; Gomez, M. R.; Zier, J.; Tang, W.; French, D. M.; Hoff, B. W.; Jordan, N.; Cruz, E.; Lau, Y. Y.; Fowler-Guzzardo, T.; Meisel, J.; Mazarakis, M. G.; Cuneo, M. E.; Johnston, M. D.; Mehlhorn, T. A.; Kim, A. A.; Sinebryukhov, V. A.

    2007-11-01

    We present designs and experimental plans of the first 1 MA z-pinch in the USA to be driven by a Linear Transformer Driver (LTD). The Michigan Accelerator for Inductive Z-pinch Experiments, (MAIZE), is based on the LTD developed at the Institute for High Current Electronics, utilizing 80 capacitors and 40 spark gap switches to deliver a 1 MA, 100 kV pulse with <100 ns risetime. Designs will be presented of a low-inductance MITL terminated in a wire-array z-pinch. Initial, planned experiments will evaluate the LTD driving time-changing inductance of imploding 4-16 wire-array z-pinches. Wire ablation dynamics, axial-correlations and instability development will be explored. *This work was supported by U. S. DoE through Sandia National Laboratories award number 240985 to the University of Michigan. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  1. Voluntary inhalation of methamphetamine: a novel strategy for studying intake non-invasively.

    PubMed

    Juarez-Portilla, C; Kim, R D; Robotham, M; Tariq, M; Pitter, M; LeSauter, J; Silver, R

    2017-03-01

    The abuse of the psychostimulant methamphetamine (MA) is associated with substantial costs and limited treatment options. To understand the mechanisms that lead to abuse, animal models of voluntary drug intake are crucial. We aimed to develop a protocol to study long-term non-invasive voluntary intake of MA in mice. Mice were maintained in their home cages and allowed daily 1 h access to an attached tunnel leading to a test chamber in which nebulized MA was available. Restated, if they went to the nebulizing chamber, they self-administered MA by inhalation. This protocol was compared to injected and to imposed exposure to nebulized MA, in a series of seven experiments. We established a concentration of nebulized MA at which motor activity increases following voluntary intake resembled that following MA injection and imposed inhalation. We found that mice regulated their exposure to MA, self-administering for shorter durations when concentrations of nebulized MA were increased. Mice acquire the available MA by repeatedly running in and out of the nebulizing chamber for brief bouts of intake. Such exposure to nebulized MA elevated plasma MA levels. There was limited evidence of sensitization of locomotor activity. Finally, blocking access to the wheel did not affect time spent in the nebulizing chamber. We conclude that administration of MA by nebulization is an effective route of self-administration, and our new protocol represents a promising tool for examining the transitions from first intake to long-term use and its behavioral and neural consequences in a non-invasive protocol.

  2. Identification and Characterization of Multiple Spidroin 1 Genes Encoding Major Ampullate Silk Proteins in Nephila clavipes

    PubMed Central

    Gaines, William A.; Marcotte, William R.

    2010-01-01

    Spider dragline silk is primarily composed of proteins called major ampullate spidroins (MaSp) that consist of a large repeat array flanked by non-repetitive N- and C-terminal domains. Until recently, there has been little evidence for more than one gene encoding each of the two major spidroin silk proteins, MaSp1 and MaSp2. Here, we report the deduced N-terminal domain sequences for two distinct MaSp1 genes from Nephila clavipes (MaSp1A and MaSp1B) and for MaSp2. All three MaSp genes are co-expressed in the major ampullate gland. A search of the GenBank database also revealed two distinct MaSp1 C-terminal domain sequences. Sequencing confirmed that both MaSp1 genes are present in all seven Nephila clavipes spiders examined. The presence of nucleotide polymorphisms in these genes confirmed that MaSp1A and MaSp1B are distinct genetic loci and not merely alleles of the same gene. We have experimentally determined the transcription start sites for all three MaSp genes and established preliminary pairing between the two MaSp1 N- and C-terminal domains. Phylogenetic analysis of these new sequences and other published MaSp N- and C-terminal domain sequences illustrated that duplications of MaSp genes may be widespread among spider species. PMID:18828837

  3. Report on Operations of the Air Force Geophysics Laboratory Infrared Array Spectrometer

    DTIC Science & Technology

    1993-01-25

    AIR FORCE GEOPHYSICS LABORATORY INFRARED ARRAY... LABORATORY Directorate of Geophysics AIR FORCE MATERIEL COMMAND HANSCOM AIR FORCE BASE, MA 01731-3010 93-27655IEEE|EIIE1ENI This technical report has...ACKNOWLEDGMENT We are grateful to the Air Force Office of Scientific Research , especially Henry Radowski. for their financial corn- mitment to this project.

  4. Evaluating the capacity of California's publicly funded universities to provide medication abortion.

    PubMed

    Raifman, Sarah; Anderson, Patricia; Kaller, Shelly; Tober, Diane; Grossman, Daniel

    2018-05-18

    To explore capacity of University of California (UC) and California State University (CSU) student health centers (SHCs) to provide medication abortion (MA) and SHC staff perspectives on providing MA. SHC staff completed an online survey; we conducted site visits and conference calls with a subset of SHCs. The survey focused on barriers to abortion, resources needed for MA, and potential benefits and challenges. 11 UCs (100%) and 20 CSUs (87%) completed surveys. All facilities provided basic primary care, including sexual and reproductive health services and some contraceptive services, but not abortion. All sites had adequate staffing and physical plant, but most would require training, access to ultrasound when needed, 24-hour hotlines (CSUs), and back-up care to provide MA. It would be feasible to provide MA at SHCs, but investment is needed to support staff training, equipment, 24-hour hotlines, back-up care, and minimal security upgrades, in order to implement MA services. If SB320 is passed, provision of MA services at student health centers could improve access to early abortion for students in California. This model may be scaled up at other universities around the country. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Estimation of linkage disequilibrium and interspecific gene flow in Ficedula flycatchers by a newly developed 50k single-nucleotide polymorphism array

    PubMed Central

    Kawakami, Takeshi; Backström, Niclas; Burri, Reto; Husby, Arild; Olason, Pall; Rice, Amber M; Ålund, Murielle; Qvarnström, Anna; Ellegren, Hans

    2014-01-01

    With the access to draft genome sequence assemblies and whole-genome resequencing data from population samples, molecular ecology studies will be able to take truly genome-wide approaches. This now applies to an avian model system in ecological and evolutionary research: Old World flycatchers of the genus Ficedula, for which we recently obtained a 1.1 Gb collared flycatcher genome assembly and identified 13 million single-nucleotide polymorphism (SNP)s in population resequencing of this species and its sister species, pied flycatcher. Here, we developed a custom 50K Illumina iSelect flycatcher SNP array with markers covering 30 autosomes and the Z chromosome. Using a number of selection criteria for inclusion in the array, both genotyping success rate and polymorphism information content (mean marker heterozygosity = 0.41) were high. We used the array to assess linkage disequilibrium (LD) and hybridization in flycatchers. Linkage disequilibrium declined quickly to the background level at an average distance of 17 kb, but the extent of LD varied markedly within the genome and was more than 10-fold higher in ‘genomic islands’ of differentiation than in the rest of the genome. Genetic ancestry analysis identified 33 F1 hybrids but no later-generation hybrids from sympatric populations of collared flycatchers and pied flycatchers, contradicting earlier reports of backcrosses identified from much fewer number of markers. With an estimated divergence time as recently as <1 Ma, this suggests strong selection against F1 hybrids and unusually rapid evolution of reproductive incompatibility in an avian system. PMID:24784959

  6. LDQ10: a compact ultra low-power radiation-hard 4 × 10 Gb/s driver array

    DOE PAGES

    Zeng, Z.; Zhang, T.; Wang, G.; ...

    2017-02-28

    Here, a High-speed and low-power VCSEL driver is an important component of the Versatile Link for the high-luminosity LHC (HL-LHC) experiments. A compact low-power radiation-hard 4 × 10 Gb/s VCSEL driver array (LDQ10) has been developed in 65 nm CMOS technology. Each channel in LDQ10 can provide a modulation current up to 8 mA and bias current up to 12 mA. Edge pre-emphasis is employed to compensate for the bandwidth limitations due to parasitic and the turn-on delay of VCSEL devices. LDQ10 occupies a chip area of 1900 μm × 1700 μm and consumes 130 mW power for typical currentmore » settings. The modulation amplitude degrades less than 5% after 300 Mrad total ionizing dose. LDQ10 can be directly wire-bonded to the VCSEL array and it is a suitable candidate for the Versatile Link.« less

  7. Matrix addressable vertical cavity surface emitting laser array

    NASA Astrophysics Data System (ADS)

    Orenstein, M.; von Lehmen, A. C.; Chang-Hasnain, C.; Stoffel, N. G.; Harbison, J. P.

    1991-02-01

    The design, fabrication and characterization of 1024-element matrix-addressable vertical-cavity surface-emitting laser (VCSEL) arrays are described. A strained InGaAs quantum-well VCSEL structure was grown by MBE, and an array of 32 x 32 lasers was defined using a proton implantation process. A matrix addressing architecture was employed, which enables the individual addressing of each of the 1024 lasers using only 64 electrical contacts. All the lasers in the array, measured after the laser definition step, were operating with fairly homogeneous characteristics; threshold current of 6.8 mA and output quantum differential efficiency of about 8 percent.

  8. Automated Handling of Garments for Pressing

    DTIC Science & Technology

    1991-09-30

    Parallel Algorithms for 2D Kalman Filtering ................................. 47 DJ. Potter and M.P. Cline Hash Table and Sorted Array: A Case Study of... Kalman Filtering on the Connection Machine ............................ 55 MA. Palis and D.K. Krecker Parallel Sorting of Large Arrays on the MasPar...ALGORITHM’VS FOR SEAM SENSING. .. .. .. ... ... .... ..... 24 6.1 KarelTW Algorithms .. .. ... ... ... ... .... ... ...... 24 6.1.1 Image Filtering

  9. Multicolor, time-gated, soft x-ray pinhole imaging of wire array and gas puff Z pinches on the Z and Saturn pulsed power generators.

    PubMed

    Jones, B; Coverdale, C A; Nielsen, D S; Jones, M C; Deeney, C; Serrano, J D; Nielsen-Weber, L B; Meyer, C J; Apruzese, J P; Clark, R W; Coleman, P L

    2008-10-01

    A multicolor, time-gated, soft x-ray pinhole imaging instrument is fielded as part of the core diagnostic set on the 25 MA Z machine [M. E. Savage et al., in Proceedings of the Pulsed Power Plasma Sciences Conference (IEEE, New York, 2007), p. 979] for studying intense wire array and gas puff Z-pinch soft x-ray sources. Pinhole images are reflected from a planar multilayer mirror, passing 277 eV photons with <10 eV bandwidth. An adjacent pinhole camera uses filtration alone to view 1-10 keV photons simultaneously. Overlaying these data provides composite images that contain both spectral as well as spatial information, allowing for the study of radiation production in dense Z-pinch plasmas. Cu wire arrays at 20 MA on Z show the implosion of a colder cloud of material onto a hot dense core where K-shell photons are excited. A 528 eV imaging configuration has been developed on the 8 MA Saturn generator [R. B. Spielman et al., and A. I. P. Conf, Proc. 195, 3 (1989)] for imaging a bright Li-like Ar L-shell line. Ar gas puff Z pinches show an intense K-shell emission from a zippering stagnation front with L-shell emission dominating as the plasma cools.

  10. Construction of Hierarchical CuO/Cu₂O@NiCo₂S₄ Nanowire Arrays on Copper Foam for High Performance Supercapacitor Electrodes.

    PubMed

    Zhou, Luoxiao; He, Ying; Jia, Congpu; Pavlinek, Vladimir; Saha, Petr; Cheng, Qilin

    2017-09-15

    Hierarchical copper oxide @ ternary nickel cobalt sulfide (CuO/Cu₂O@NiCo₂S₄) core-shell nanowire arrays on Cu foam have been successfully constructed by a facile two-step strategy. Vertically aligned CuO/Cu₂O nanowire arrays are firstly grown on Cu foam by one-step thermal oxidation of Cu foam, followed by electrodeposition of NiCo₂S₄ nanosheets on the surface of CuO/Cu₂O nanowires to form the CuO/Cu₂O@NiCo₂S₄ core-shell nanostructures. Structural and morphological characterizations indicate that the average thickness of the NiCo₂S₄ nanosheets is ~20 nm and the diameter of CuO/Cu₂O core is ~50 nm. Electrochemical properties of the hierarchical composites as integrated binder-free electrodes for supercapacitor were evaluated by various electrochemical methods. The hierarchical composite electrodes could achieve ultrahigh specific capacitance of 3.186 F cm -2 at 10 mA cm -2 , good rate capability (82.06% capacitance retention at the current density from 2 to 50 mA cm -2 ) and excellent cycling stability, with capacitance retention of 96.73% after 2000 cycles at 10 mA cm -2 . These results demonstrate the significance of optimized design and fabrication of electrode materials with more sufficient electrolyte-electrode interface, robust structural integrity and fast ion/electron transfer.

  11. Solar Energy Investigation Activities for Primary Pupils: Experience Sharing from a Teacher of a Solar Energy School in Hong Kong

    ERIC Educational Resources Information Center

    Cho, Kit Fan

    2005-01-01

    CCC Kei Wai Primary School (Ma Wan) is a 30-classroom 7-story primary school located at Ma Wan Island. The campus was completed in 2003. There are three arrays of photovoltaic modules installed on the roof with an expected annual yield of 5600 kWh a.c. electricity. This system is supported by a research project called "Building Integrated…

  12. A natural mutation-led truncation in one of the two aluminum-activated malate transporter-like genes at the Ma locus is associated with low fruit acidity in apple.

    PubMed

    Bai, Yang; Dougherty, Laura; Li, Mingjun; Fazio, Gennaro; Cheng, Lailiang; Xu, Kenong

    2012-08-01

    Acidity levels greatly affect the taste and flavor of fruit, and consequently its market value. In mature apple fruit, malic acid is the predominant organic acid. Several studies have confirmed that the major quantitative trait locus Ma largely controls the variation of fruit acidity levels. The Ma locus has recently been defined in a region of 150 kb that contains 44 predicted genes on chromosome 16 in the Golden Delicious genome. In this study, we identified two aluminum-activated malate transporter-like genes, designated Ma1 and Ma2, as strong candidates of Ma by narrowing down the Ma locus to 65-82 kb containing 12-19 predicted genes depending on the haplotypes. The Ma haplotypes were determined by sequencing two bacterial artificial chromosome clones from G.41 (an apple rootstock of genotype Mama) that cover the two distinct haplotypes at the Ma locus. Gene expression profiling in 18 apple germplasm accessions suggested that Ma1 is the major determinant at the Ma locus controlling fruit acidity as Ma1 is expressed at a much higher level than Ma2 and the Ma1 expression is significantly correlated with fruit titratable acidity (R (2) = 0.4543, P = 0.0021). In the coding sequences of low acidity alleles of Ma1 and Ma2, sequence variations at the amino acid level between Golden Delicious and G.41 were not detected. But the alleles for high acidity vary considerably between the two genotypes. The low acidity allele of Ma1, Ma1-1455A, is mainly characterized by a mutation at base 1455 in the open reading frame. The mutation leads to a premature stop codon that truncates the carboxyl terminus of Ma1-1455A by 84 amino acids compared with Ma1-1455G. A survey of 29 apple germplasm accessions using marker CAPS(1455) that targets the SNP(1455) in Ma1 showed that the CAPS(1455A) allele was associated completely with high pH and highly with low titratable acidity, suggesting that the natural mutation-led truncation is most likely responsible for the abolished function of Ma for low pH or high acidity in apple.

  13. SCHeMA web-based observation data information system

    NASA Astrophysics Data System (ADS)

    Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

    2016-04-01

    It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by SeaDataNet network of National Oceanographic Data Centres. The SCHeMA presentation layer, a fundamental part of the software architecture, offers to the user a bidirectional interaction with the integrated system allowing to manage and configure the sensor probes; view the stored observations and metadata, and handle alarms. The overall structure of the web portal developed within the SCHeMA initiative (Sensor Configuration, development of Core Profile interface for data access via OGC standard, external services such as web services, WMS, WFS; and Data download and query manager) will be presented and illustrated with examples of ongoing tests in costal and open sea.

  14. Compact hohlraum configuration with parallel planar-wire-array x-ray sources at the 1.7-MA Zebra generator.

    PubMed

    Kantsyrev, V L; Chuvatin, A S; Rudakov, L I; Velikovich, A L; Shrestha, I K; Esaulov, A A; Safronova, A S; Shlyaptseva, V V; Osborne, G C; Astanovitsky, A L; Weller, M E; Stafford, A; Schultz, K A; Cooper, M C; Cuneo, M E; Jones, B; Vesey, R A

    2014-12-01

    A compact Z-pinch x-ray hohlraum design with parallel-driven x-ray sources is experimentally demonstrated in a configuration with a central target and tailored shine shields at a 1.7-MA Zebra generator. Driving in parallel two magnetically decoupled compact double-planar-wire Z pinches has demonstrated the generation of synchronized x-ray bursts that correlated well in time with x-ray emission from a central reemission target. Good agreement between simulated and measured hohlraum radiation temperature of the central target is shown. The advantages of compact hohlraum design applications for multi-MA facilities are discussed.

  15. Kuznetsov-Ma Soliton Dynamics Based on the Mechanical Effect of Light

    NASA Astrophysics Data System (ADS)

    Xiong, Hao; Gan, Jinghui; Wu, Ying

    2017-10-01

    A Kuznetsov-Ma soliton that exhibits an unusual pulsating dynamics has attracted particular attention in hydrodynamics and plasma physics in the context of understanding nonlinear coherent phenomena. Here, we demonstrate theoretically the formation of a novel form of Kuznetsov-Ma soliton in a microfabricated optomechanical array, where both photonic and phononic evolutionary dynamics exhibit periodic structure and coherent localized behavior enabled by radiation-pressure coupling of optical fields and mechanical oscillations, which is a manifestation of the unique property of optomechanical systems. Numerical calculations of the optomechanical dynamics show an excellent agreement with this theory. In addition to providing insight into optomechanical nonlinearity, optomechanical Kuznetsov-Ma soliton dynamics fundamentally broadens the regime of cavity optomechanics and may find applications in on-chip manipulation of light propagation.

  16. DFB laser array driver circuit controlled by adjustable signal

    NASA Astrophysics Data System (ADS)

    Du, Weikang; Du, Yinchao; Guo, Yu; Li, Wei; Wang, Hao

    2018-01-01

    In order to achieve the intelligent controlling of DFB laser array, this paper presents the design of an intelligence and high precision numerical controlling electric circuit. The system takes MCU and FPGA as the main control chip, with compact, high-efficiency, no impact, switching protection characteristics. The output of the DFB laser array can be determined by an external adjustable signal. The system transforms the analog control model into a digital control model, which improves the performance of the driver. The system can monitor the temperature and current of DFB laser array in real time. The output precision of the current can reach ± 0.1mA, which ensures the stable and reliable operation of the DFB laser array. Such a driver can benefit the flexible usage of the DFB laser array.

  17. A Novel Multiple-Access Correlation-Delay-Shift-Keying

    NASA Astrophysics Data System (ADS)

    Duan, J. Y.; Jiang, G. P.; Yang, H.

    In Correlation-Delay-Shift-Keying (CDSK), the reference signal and the information-bearing signal are added together during a certain time delay. Because the reference signal is not strictly orthogonal to the information-bearing signal, the cross-correlation between the adjacent chaotic signal (Intra-signal Interference, ISI) will be introduced into the demodulation at the receiver. Therefore, the Bit-Error Ratio (BER) of CDSK is higher than that of Differential-Chaos-Shift-Keying (DCSK). To avoid the ISI component and enhance the BER performance of CDSK in multiuser scenario, Multiple-Access CDSK with No Intra-signal Interference (MA-CDSK-NII) is proposed. By constructing the repeated chaotic generator and applying the Walsh code sequence to modulate the reference signal, in MA-CDSK-NII, the ISI component will be eliminated during the demodulation. Gaussian approximation method is adopted here to obtain the exact performance analysis of MA-CDSK-NII over additive white Gaussian noise (AWGN) channel and Rayleigh multipath fading channels. Results show that, due to no ISI component and lower transmitting power, the BER performance of MA-CDSK-NII can be better than that of multiple-access CDSK and Code-Shifted Differential-Chaos-Shift-Keying (CS-DCSK).

  18. Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory.

    PubMed

    Becker, Pablo D; Hervouet, Catherine; Mason, Gavin M; Kwon, Sung-Yun; Klavinskis, Linda S

    2015-09-08

    A simple dissolvable microneedle array (MA) platform has emerged as a promising technology for vaccine delivery, due to needle-free injection with a formulation that preserves the immunogenicity of live viral vectored vaccines dried in the MA matrix. While recent studies have focused largely on design parameters optimized to induce primary CD8(+) T cell responses, the hallmark of a vaccine is synonymous with engendering long-lasting memory. Here, we address the capacity of dried MA vaccination to programme phenotypic markers indicative of effector/memory CD8(+) T cell subsets and also responsiveness to recall antigen benchmarked against conventional intradermal (ID) injection. We show that despite a slightly lower frequency of dividing T cell receptor transgenic CD8(+) T cells in secondary lymphoid tissue at an early time point, the absolute number of CD8(+) T cells expressing an effector memory (CD62L(-)CD127(+)) and central memory (CD62L(+)CD127(+)) phenotype during peak expansion were comparable after MA and ID vaccination with a recombinant human adenovirus type 5 vector (AdHu5) encoding HIV-1 gag. Similarly, both vaccination routes generated CD8(+) memory T cell subsets detected in draining LNs for at least two years post-vaccination capable of responding to secondary antigen. These data suggest that CD8(+) T cell effector/memory generation and long-term memory is largely unaffected by physical differences in vaccine delivery to the skin via dried MA or ID suspension. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays

    PubMed Central

    Bachy, Veronique; Hervouet, Catherine; Becker, Pablo D.; Chorro, Laurent; Carlin, Leo M.; Herath, Shanthi; Papagatsias, Timos; Barbaroux, Jean-Baptiste; Oh, Sea-Jin; Benlahrech, Adel; Athanasopoulos, Takis; Dickson, George; Patterson, Steven; Kwon, Sung-Yun; Geissmann, Frederic; Klavinskis, Linda S.

    2013-01-01

    Stabilization of virus protein structure and nucleic acid integrity is challenging yet essential to preserve the transcriptional competence of live recombinant viral vaccine vectors in the absence of a cold chain. When coupled with needle-free skin delivery, such a platform would address an unmet need in global vaccine coverage against HIV and other global pathogens. Herein, we show that a simple dissolvable microneedle array (MA) delivery system preserves the immunogenicity of vaccines encoded by live recombinant human adenovirus type 5 (rAdHu5). Specifically, dried rAdHu5 MA immunization induced CD8+ T-cell expansion and multifunctional cytokine responses equipotent with conventional injectable routes of immunization. Intravital imaging demonstrated MA cargo distributed both in the epidermis and dermis, with acquisition by CD11c+ dendritic cells (DCs) in the dermis. The MA immunizing properties were attributable to CD11c+ MHCIIhi CD8αneg epithelial cell adhesion molecule (EpCAMneg) CD11b+ langerin (Lang; CD207)neg DCs, but neither Langerhans cells nor Lang+ DCs were required for CD8+ T-cell priming. This study demonstrates an important technical advance for viral vaccine vectors progressing to the clinic and provides insights into the mechanism of CD8+ T-cell priming by live rAdHu5 MAs. PMID:23386724

  20. Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays.

    PubMed

    Bachy, Veronique; Hervouet, Catherine; Becker, Pablo D; Chorro, Laurent; Carlin, Leo M; Herath, Shanthi; Papagatsias, Timos; Barbaroux, Jean-Baptiste; Oh, Sea-Jin; Benlahrech, Adel; Athanasopoulos, Takis; Dickson, George; Patterson, Steven; Kwon, Sung-Yun; Geissmann, Frederic; Klavinskis, Linda S

    2013-02-19

    Stabilization of virus protein structure and nucleic acid integrity is challenging yet essential to preserve the transcriptional competence of live recombinant viral vaccine vectors in the absence of a cold chain. When coupled with needle-free skin delivery, such a platform would address an unmet need in global vaccine coverage against HIV and other global pathogens. Herein, we show that a simple dissolvable microneedle array (MA) delivery system preserves the immunogenicity of vaccines encoded by live recombinant human adenovirus type 5 (rAdHu5). Specifically, dried rAdHu5 MA immunization induced CD8(+) T-cell expansion and multifunctional cytokine responses equipotent with conventional injectable routes of immunization. Intravital imaging demonstrated MA cargo distributed both in the epidermis and dermis, with acquisition by CD11c(+) dendritic cells (DCs) in the dermis. The MA immunizing properties were attributable to CD11c(+) MHCII(hi) CD8α(neg) epithelial cell adhesion molecule (EpCAM(neg)) CD11b(+) langerin (Lang; CD207)(neg) DCs, but neither Langerhans cells nor Lang(+) DCs were required for CD8(+) T-cell priming. This study demonstrates an important technical advance for viral vaccine vectors progressing to the clinic and provides insights into the mechanism of CD8(+) T-cell priming by live rAdHu5 MAs.

  1. MoSe2 modified TiO2 nanotube arrays with superior photoelectrochemical performance

    NASA Astrophysics Data System (ADS)

    Zhang, Yaping; Zhu, Haifeng; Yu, Lianqing; He, Jiandong; Huang, Chengxing

    2018-04-01

    TiO2 nanotube arrays (TNTs) are first prepared by anodization Ti foils in ethylene glycol electrolyte. Then, MoSe2 deposites electrochemically on TNTs. The as-synthesized MoSe2/TiO2 composite has a much higher photocurrent density of 1.07 mA cm‑2 at 0 V than pure TNTs of 0.38 mA cm‑2, which suggests that the MoSe2/TiO2 composite film has optimum photoelectrocatalysis properties. The electron transport resistances of the MoSe2/TiO2 decreases to half of pure TiO2, at 295.6 ohm/cm2. Both photocurrent-time and Mott-Schottky plots indicate MoSe2 a p-type semiconductor characteristics. MoSe2/TiO2 composite can achieve a maximum 5 orders of magnitude enhancement in carrier density (4.650 × 1027 cm‑3) than that of pure TiO2 arrays. It can be attributed to p-n heterojunction formed between MoSe2 and TiO2, and the composite can be potentially applied in photoelectrochemical, photocatalysis fields.

  2. Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery.

    PubMed

    Li, Jiyu; Liu, Bin; Zhou, Yingying; Chen, Zhipeng; Jiang, Lelun; Yuan, Wei; Liang, Liang

    2017-01-01

    Microneedle arrays (MA) have been extensively investigated in recent decades for transdermal drug delivery due to their pain-free delivery, minimal skin trauma, and reduced risk of infection. However, porous MA received relatively less attention due to their complex fabrication process and ease of fracturing. Here, we present a titanium porous microneedle array (TPMA) fabricated by modified metal injection molding (MIM) technology. The sintering process is simple and suitable for mass production. TPMA was sintered at a sintering temperature of 1250°C for 2 h. The porosity of TPMA was approximately 30.1% and its average pore diameter was about 1.3 μm. The elements distributed on the surface of TPMA were only Ti and O, which may guarantee the biocompatibility of TPMA. TPMA could easily penetrate the skin of a human forearm without fracture. TPMA could diffuse dry Rhodamine B stored in micropores into rabbit skin. The cumulative permeated flux of calcein across TPMA with punctured skin was 27 times greater than that across intact skin. Thus, TPMA can continually and efficiently deliver a liquid drug through open micropores in skin.

  3. Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring

    PubMed Central

    Ren, Lei; Jiang, Qing; Chen, Keyun; Chen, Zhipeng; Pan, Chengfeng; Jiang, Lelun

    2016-01-01

    A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring. PMID:27322278

  4. Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring.

    PubMed

    Ren, Lei; Jiang, Qing; Chen, Keyun; Chen, Zhipeng; Pan, Chengfeng; Jiang, Lelun

    2016-06-17

    A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring.

  5. 76 FR 543 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... England Fishery Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950; telephone: (978) 465... representative will present an outline of their project--a networked sensor system array proposed for offshore...

  6. Design and fabrication of AlGaInP-based micro-light-emitting-diode array devices

    NASA Astrophysics Data System (ADS)

    Bao, Xingzhen; Liang, Jingqiu; Liang, Zhongzhu; Wang, Weibiao; Tian, Chao; Qin, Yuxin; Lü, Jinguang

    2016-04-01

    An integrated high-resolution (individual pixel size 80 μm×80 μm) solid-state self-emissive active matrix programmed with 320×240 micro-light-emitting-diode arrays structure was designed and fabricated on an AlGaInP semiconductor chip using micro electro-mechanical systems, microstructure and semiconductor fabricating techniques. Row pixels share a p-electrode and line pixels share an n-electrode. We experimentally investigated GaAs substrate thickness affects the electrical and optical characteristics of the pixels. For a 150-μm-thick GaAs substrate, the single pixel output power was 167.4 μW at 5 mA, and increased to 326.4 μW when current increase to 10 mA. The device investigated potentially plays an important role in many fields.

  7. Amorphous Ni(Fe)OxHy-coated nanocone arrays self-supported on stainless steel mesh as a promising oxygen-evolving anode for large scale water splitting

    NASA Astrophysics Data System (ADS)

    Shen, Junyu; Wang, Mei; Zhao, Liang; Zhang, Peili; Jiang, Jian; Liu, Jinxuan

    2018-06-01

    The development of highly efficient, robust, and cheap water oxidation electrodes is a major challenge in constructing industrially applicable electrolyzers for large-scale production of hydrogen from water. Herein we report a hierarchical stainless steel mesh electrode which features Ni(Fe)OxHy-coated self-supported nanocone arrays. Through a facile, mild, low-cost and readily scalable two-step fabrication procedure, the electrochemically active area of the optimized electrode is enlarged by a factor of 3.1 and the specific activity is enhanced by a factor of 250 at 265 mV overpotential compared with that of a corresponding pristine stainless steel mesh electrode. Moreover, the charge-transfer resistance is reduced from 4.47 Ω for the stainless steel mesh electrode to 0.13 Ω for the Ni(Fe)OxHy-coated nanocone array stainless steel mesh electrode. As a result, the cheap and easily fabricated electrode displays 280 and 303 mV low overpotentials to achieve high current densities of 500 and 1000 mA cmgeo-2, respectively, for oxygen evolution reaction in 1 M KOH. More importantly, the electrode exhibits a good stability over 340 h of chronopotentiometric test at 50 mA cmgeo-2 and only a slight attenuation (4.2%, ∼15 mV) in catalytic activity over 82 h electrolysis at a constant current density of 500 mA cmgeo-2.

  8. Construction of Hierarchical CuO/Cu2O@NiCo2S4 Nanowire Arrays on Copper Foam for High Performance Supercapacitor Electrodes

    PubMed Central

    Zhou, Luoxiao; He, Ying; Jia, Congpu; Pavlinek, Vladimir; Saha, Petr; Cheng, Qilin

    2017-01-01

    Hierarchical copper oxide @ ternary nickel cobalt sulfide (CuO/Cu2O@NiCo2S4) core-shell nanowire arrays on Cu foam have been successfully constructed by a facile two-step strategy. Vertically aligned CuO/Cu2O nanowire arrays are firstly grown on Cu foam by one-step thermal oxidation of Cu foam, followed by electrodeposition of NiCo2S4 nanosheets on the surface of CuO/Cu2O nanowires to form the CuO/Cu2O@NiCo2S4 core-shell nanostructures. Structural and morphological characterizations indicate that the average thickness of the NiCo2S4 nanosheets is ~20 nm and the diameter of CuO/Cu2O core is ~50 nm. Electrochemical properties of the hierarchical composites as integrated binder-free electrodes for supercapacitor were evaluated by various electrochemical methods. The hierarchical composite electrodes could achieve ultrahigh specific capacitance of 3.186 F cm−2 at 10 mA cm−2, good rate capability (82.06% capacitance retention at the current density from 2 to 50 mA cm−2) and excellent cycling stability, with capacitance retention of 96.73% after 2000 cycles at 10 mA cm−2. These results demonstrate the significance of optimized design and fabrication of electrode materials with more sufficient electrolyte-electrode interface, robust structural integrity and fast ion/electron transfer. PMID:28914819

  9. NiCo2S4 nanotube arrays grown on flexible nitrogen-doped carbon foams as three-dimensional binder-free integrated anodes for high-performance lithium-ion batteries.

    PubMed

    Wu, Xiaoyu; Li, Songmei; Wang, Bo; Liu, Jianhua; Yu, Mei

    2016-02-14

    Binary metal sulfides, especially NiCo2S4, hold great promise as anode materials for high-performance lithium-ion batteries because of their excellent electronic conductivity and high capacity compared to mono-metal sulfides and oxides. Here, NiCo2S4 nanotube arrays are successfully grown on flexible nitrogen-doped carbon foam (NDCF) substrates with robust adhesion via a facile surfactant-assisted hydrothermal route and the subsequent sulfurization treatment. The obtained NiCo2S4/NDCF composites show unique three-dimensional architectures, in which NiCo2S4 nanotubes of ∼5 μm in length and 100 nm in width are uniformly grown on the NDCF skeletons to form arrays. When used directly as integrated anodes for lithium-ion batteries without any conductive additives and binders, the NiCo2S4/NDCF composites exhibit a high reversible capacity of 1721 mA h g(-1) at a high current density of 500 mA g(-1), enhanced cycling performance with the capacity maintained at 1182 mA h g(-1) after 100 cycles, and a remarkable rate capability. The excellent lithium storage performances of the composites could be attributed to the unique material composition, a rationally designed hollow nanostructure and an integrated smart architecture, which offer fast electron transport and ion diffusion, enhanced material/-electrolyte contact area and facile accommodation of strains during the lithium insertion and extraction process.

  10. Use of a custom RT-PCR array to analyze toxicity pathways at different life stages in Brown Norway Rat Brain following acute Toluene exposure.

    EPA Science Inventory

    To investigate the contribution of different life stages on response to toxicants, we utilized a custom designed RT-PCR array to examine the effects of acute exposure by oral gavage of the volatile organic solvent toluene (0.00, 0.65 or 1.0 glkg) in the brains of ma1e Brown Norwa...

  11. Three-dimensional TiO2 nanowire@NiMoO4 ultrathin nanosheet core-shell arrays for lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Cao, Minglei; Bu, Yi; Lv, Xiaowei; Jiang, Xingxing; Wang, Lichuan; Dai, Sirui; Wang, Mingkui; Shen, Yan

    2018-03-01

    This study reports a general and rational two-step hydrothermal strategy to fabricate three-dimensional (3D) TiO2 nanowire@NiMoO4 ultrathin nanosheet core-shell arrays (TNAs-NMO) as additives-free anodes for lithium-ion batteries (LIBs). The TNAs-NMO electrode delivers a reversible capacity of up to 446.6 mA h g-1 over 120 cycles at the current density of 0.2 A g-1 and a high rate capacity of 234.2 mA h g-1 at 2.0 A g-1. Impressively, the capacity retention efficiency is 74.7% after 2500 cycles at the high rate of 2.0 A g-1. In addition, the full cell consisting of TNAs-NMO anode and LCO cathode can afford a specific energy of up to 220.3 W h kg-1 (based on the entire mass of both electrodes). The high electrochemical performance of the TNAs-NMO electrode is ascribed to its 3D core-shell nanowire array architecture, in which the TiO2 nanowire arrays (TNAs) and the ultrathin NiMoO4 nanosheets exhibit strong synergistic effects. The TNAs maintain mechanical integrity of the electrode and the ultrathin NiMoO4 nanosheets contribute to high capacity and favorable electronic conductivity.

  12. New Planar Wire Array Experiments on the LTD Generator at U Michigan

    NASA Astrophysics Data System (ADS)

    Weller, M. E.; Safronova, A. S.; Kantsyrev, V. L.; Shrestha, I.; Shlyaptseva, V. V.; Cooper, M. C.; Lorance, M. Y.; Stafford, A.; Petkov, E. E.; Jordan, N. M.; Patel, S. G.; Steiner, A. M.; Yager-Elorriaga, D. A.; Gilgenbach, R. M.

    2014-10-01

    Experiments on planar wire array z-pinches have been carried out on the MAIZE Linear Transformer Driver (LTD) generator at the University of Michigan (UM) for the first time. Specifically, Al (Al 5056, 95% Al, 5% Mg) double planar wire arrays (DPWAs) comprising six wires in each plane with interplanar gaps of 3.0 mm and 6.0 mm and interwire gaps of 0.7 mm and 1.0 mm were imploded with x-ray time-integrated spectra indicating electron temperatures of over 450 eV for K-shell Al and Mg, while producing mostly optically thin lines. In addition to x-ray time-integrated spectra, the diagnostics included x-ray time-integrated pinhole cameras, two silicon diodes, and shadowgraphy, which are analyzed and compared. The MAIZE LTD is capable of supplying up 1.0 MA, 100 kV pulses with 100 ns rise time into a matched load. However, for these experiments the LTD was charged to +-70 kV resulting in up to 0.5 MA with a current rise time of approximately 150 ns. Future experiments and the importance of studying planar wire arrays on LTD devices are discussed. This work supported by NNSA under DOE Cooperative Agreement DE-NA0001984. S. Patel & A. Steiner supported by Sandia. D. Yager-Elorriaga supported by NSF GF.

  13. Optical Characteristics of Vertical Cavity Surface Emitting Lasers and Two Dimensional Coherently Coupled Arrays.

    NASA Astrophysics Data System (ADS)

    Catchmark, Jeffrey Michael

    1995-01-01

    The following describes extensive experimental and theoretical research concerning the optical, electrical and thermal characteristics of GaAs/AlGaAs vertical cavity surface emitting lasers (VCSELs) and coherently coupled two dimensional VCSEL arrays grown by molecular beam epitaxy. The temperature and wavelength performance of VCSELs containing various epitaxial designs is discussed in detail. By employing a high barrier confinement spacer region and by blue shifting the optical gain with respect to the Fabry Perot transmission wavelength, greater than 150^circ rm C continuous wave operation was obtained. This is accomplished while maintaining a variation in the threshold current of only +/-0.93mA over a temperature range of 150^circrm C. This exceptional performance is achieved while attaining a minimum threshold current of approximately 4.3mA at 75^circrm C. In addition, the optical characteristics of multi-transverse mode VCSEL arrays are examined experimentally. A total of nine transverse modes have been identified and are found to couple coherently into distinct array modes. While operating in higher order transverse modes, a record 1.4W (pulsed) of optical power is obtained from a 15 x 15 VCSEL array. Array mode formation in coherently coupled VCSEL arrays is also examined theoretically. A numerical model is developed to describe the formation of supermodes in reflectivity modulated VCSEL arrays. Using this model, the effects of depth of reflectivity modulation, cavity length, window size and grid size on mode formation are explored. The array modes predicted by this model are in agreement with those observed experimentally. Analytic models will also be presented describing the effects of thermally induced waveguiding on the optical characteristics of VCSELs operating in the fundamental transverse mode. A thermal waveguide is found to have a significant effect on the spot size and radius of curvature of the phase of the fundamental optical mode. In addition, an analytic model is developed to predict the higher order transverse modes of a VCSEL exhibiting a cruciform type geometry.

  14. Transfer of Methamphetamine (MA) into Breast Milk and Urine of Postpartum Women who Smoked MA Tablets during Pregnancy: Implications for Initiation of Breastfeeding.

    PubMed

    Chomchai, Chulathida; Chomchai, Summon; Kitsommart, Ratchada

    2016-05-01

    Methamphetamine (MA) use by pregnant women remains a growing problem in South East Asia. After delivery, a negative maternal urine MA assay is assumed to reflect the absence of MA in breast milk and marks breastfeeding initiation. To date, no data exist that describe the relationship between the peripartum and postpartum transfer of MA into breast milk and its urinary excretion in women, following recreational use by smoking. This study aimed to determine the pharmacokinetic of smoked MA in breast milk and its relationship to urinary MA excretion in postpartum women who tested positive for MA before delivery. Timed urine and breast milk samples of 33 women who had positive urine drug screens for MA prior to delivery were analyzed for MA using Acquity Ultra Performance Liquid Chromatography (Waters, Milford, Massachusetts, USA) with the ACQUITY UPLC Photodiode Array Detector (Waters). Those participants with 4 or more timed breast milk samples were included for pharmacokinetic calculation using log-linear trapezoidal rule. Pharmacokinetic data from 2 women were analyzed. The half-life values for MA in the breast milk were 11.3 and 40.3 hours. The absolute infant doses were 21.3 and 51.7 µg/kg/day. Methamphetamine disappears from breast milk approximately 1 day before the maternal urine MA becomes negative. Smoked MA shows a similar breast milk pharmacokinetic pattern to previously reported intravenous MA. Breastfeeding can be safely initiated in mothers whose urine MA screen has turned negative for ≥ 24 hours. However, concurrent maternal substance use treatment and screening is necessary for continued promotion of lactation. © The Author(s) 2015.

  15. Rational construction of three dimensional hybrid Co3O4@NiMoO4 nanosheets array for energy storage application

    NASA Astrophysics Data System (ADS)

    Hong, Wei; Wang, Jinqing; Gong, Peiwei; Sun, Jinfeng; Niu, Lengyuan; Yang, Zhigang; Wang, Zhaofeng; Yang, Shengrong

    2014-12-01

    Electrodes with rationally designed hybrid nanostructures can offer many opportunities for the enhanced performance in electrochemical energy storage. In this work, the uniform 2D Co3O4-based building blocks have been prepared through a facile chemical etching assistant approach and a following treatment of thermal annealing. The obtained nanosheets array has been directly employed as 2D backbone for the subsequent construction of hybrid nanostructure of Co3O4@NiMoO4 by a simple hydrothermal synthesis. As a binder-free electrode, the constructed 3D hybrid nanostructures exhibit a high specific capacitance of 1526 F g-1 at a current density of 3 mA cm-2 and a capacitance retention of 72% with the increase of current density from 3 mA cm-2 to 30 mA cm-2. Moreover, an asymmetric supercapacitor based on this hybrid Co3O4@NiMoO4 and activated carbon can deliver a maximum energy density of 37.8 Wh kg-1 at a power density of 482 W kg-1. The outstanding electrochemical behaviors presented here suggest that this hybrid nanostructured material has potential applications in energy storage.

  16. In situ growth of NiCo2S4 nanotube arrays on Ni foam for supercapacitors: Maximizing utilization efficiency at high mass loading to achieve ultrahigh areal pseudocapacitance

    NASA Astrophysics Data System (ADS)

    Chen, Haichao; Jiang, Jianjun; Zhang, Li; Xia, Dandan; Zhao, Yuandong; Guo, Danqing; Qi, Tong; Wan, Houzhao

    2014-05-01

    Self-standing NiCo2S4 nanotube arrays have been in situ grown on Ni foam by the anion-exchange reaction and directly used as the electrode for supercapacitors. The NiCo2S4 nanotube in the arrays effectively reduces the inactive material and increases the electroactive surface area because of the ultrathin wall, which is quite competent to achieve high utilization efficiency at high electroactive materials mass loading. The NiCo2S4 nanotube arrays hybrid electrode exhibits an ultrahigh specific capacitance of 14.39 F cm-2 at 5 mA cm-2 with excellent rate performance (67.7% retention for current increases 30 times) and cycling stability (92% retention after 5000 cycles) at a high mass loading of 6 mg cm-2. High areal capacitance (4.68 F cm-2 at 10 mA cm-2), high energy density (31.5 Wh kg-1 at 156.6 W kg-1) and high power density (2348.5 W kg-1 at 16.6 Wh kg-1) can be achieved by assembling asymmetric supercapacitor with reduced graphene oxide at a total active material mass loading as high as 49.5 mg. This work demonstrates that NiCo2S4 nanotube arrays structure is a superior electroactive material for high-performance supercapacitors even at a mass loading of potential application-specific scale.

  17. Hollow TiO2@Co9S8 Core–Branch Arrays as Bifunctional Electrocatalysts for Efficient Oxygen/Hydrogen Production

    PubMed Central

    Deng, Shengjue; Zhong, Yu; Zeng, Yinxiang; Wang, Yadong; Wang, Xiuli; Tu, Jiangping

    2017-01-01

    Abstract Designing ever more efficient and cost‐effective bifunctional electrocatalysts for oxygen/hydrogen evolution reactions (OER/HER) is greatly vital and challenging. Here, a new type of binder‐free hollow TiO2@Co9S8 core–branch arrays is developed as highly active OER and HER electrocatalysts for stable overall water splitting. Hollow core–branch arrays of TiO2@Co9S8 are readily realized by the rational combination of crosslinked Co9S8 nanoflakes on TiO2 core via a facile and powerful sulfurization strategy. Arising from larger active surface area, richer/shorter transfer channels for ions/electrons, and reinforced structural stability, the as‐obtained TiO2@Co9S8 core–branch arrays show noticeable exceptional electrocatalytic performance, with low overpotentials of 240 and 139 mV at 10 mA cm−2 as well as low Tafel slopes of 55 and 65 mV Dec−1 for OER and HER in alkaline medium, respectively. Impressively, the electrolysis cell based on the TiO2@Co9S8 arrays as both cathode and anode exhibits a remarkably low water splitting voltage of 1.56 V at 10 mA cm−2 and long‐term durability with no decay after 10 d. The versatile fabrication protocol and smart branch‐core design provide a new way to construct other advanced metal sulfides for energy conversion and storage. PMID:29593976

  18. Hollow TiO2@Co9S8 Core-Branch Arrays as Bifunctional Electrocatalysts for Efficient Oxygen/Hydrogen Production.

    PubMed

    Deng, Shengjue; Zhong, Yu; Zeng, Yinxiang; Wang, Yadong; Wang, Xiuli; Lu, Xihong; Xia, Xinhui; Tu, Jiangping

    2018-03-01

    Designing ever more efficient and cost-effective bifunctional electrocatalysts for oxygen/hydrogen evolution reactions (OER/HER) is greatly vital and challenging. Here, a new type of binder-free hollow TiO 2 @Co 9 S 8 core-branch arrays is developed as highly active OER and HER electrocatalysts for stable overall water splitting. Hollow core-branch arrays of TiO 2 @Co 9 S 8 are readily realized by the rational combination of crosslinked Co 9 S 8 nanoflakes on TiO 2 core via a facile and powerful sulfurization strategy. Arising from larger active surface area, richer/shorter transfer channels for ions/electrons, and reinforced structural stability, the as-obtained TiO 2 @Co 9 S 8 core-branch arrays show noticeable exceptional electrocatalytic performance, with low overpotentials of 240 and 139 mV at 10 mA cm -2 as well as low Tafel slopes of 55 and 65 mV Dec -1 for OER and HER in alkaline medium, respectively. Impressively, the electrolysis cell based on the TiO 2 @Co 9 S 8 arrays as both cathode and anode exhibits a remarkably low water splitting voltage of 1.56 V at 10 mA cm -2 and long-term durability with no decay after 10 d. The versatile fabrication protocol and smart branch-core design provide a new way to construct other advanced metal sulfides for energy conversion and storage.

  19. Methylation array data can simultaneously identify individuals and convey protected health information: an unrecognized ethical concern.

    PubMed

    Philibert, Robert A; Terry, Nicolas; Erwin, Cheryl; Philibert, Winter J; Beach, Steven Rh; Brody, Gene H

    2014-01-01

    Genome-wide methylation arrays are increasingly used tools in studies of complex medical disorders. Because of their expense and potential utility to the scientific community, current federal policy dictates that data from these arrays, like those from genome-wide genotyping arrays, be deposited in publicly available databases. Unlike the genotyping information, access to the expression data is not restricted. An underlying supposition in the current nonrestricted access to methylation data is the belief that protected health and personal identifying information cannot be simultaneously extracted from these arrays. In this communication, we analyze methylation data from the Illumina HumanMethylation450 array and show that genotype at 1,069 highly informative loci, and both alcohol and smoking consumption information, can be derived from the array data. We conclude that both potentially personally identifying information and substance-use histories can be simultaneously derived from methylation array data. Because access to genetic information about a database subject or one of their relatives is critical to the de-identification process, this risk of de-identification is limited at the current time. We propose that access to genome-wide methylation data be restricted to institutionally approved investigators who accede to data use agreements prohibiting re-identification.

  20. Self-supported three-dimensional Cu/Cu2O-CuO/rGO nanowire array electrodes for an efficient hydrogen evolution reaction.

    PubMed

    Ye, Lin; Wen, Zhenhai

    2018-06-14

    We report the fabrication of self-supported Cu/Cu2O-CuO/rGO nanowire arrays on commercial porous copper foam, which exhibit excellent activity and durability for electrochemical hydrogen evolution, presenting a small onset potential of 84 mV and a low overpotential of 105 mV at a current density of 10 mA cm-2.

  1. Cost-effectiveness analysis of unsafe abortion and alternative first-trimester pregnancy termination strategies in Nigeria and Ghana.

    PubMed

    Hu, Delphine; Grossman, Daniel; Levin, Carol; Blanchard, Kelly; Adanu, Richard; Goldie, Sue J

    2010-06-01

    To explore the policy implications of increasing access to safe abortion in Nigeria and Ghana, we developed a computer-based decision analytic model which simulates induced abortion and its potential complications in a cohort of women, and comparatively assessed the cost-effectiveness of unsafe abortion and three first-trimester abortion modalities: hospital-based dilatation and curettage, hospital- and clinic-based manual vacuum aspiration (MVA), and medical abortion using misoprostol (MA). Assuming all modalities are equally available, clinic-based MVA is the most cost-effective option in Nigeria. If clinic-based MVA is not available, MA is the next best strategy. Conversely, in Ghana, MA is the most cost-effective strategy, followed by clinic-based MVA if MA is not available. From a real world policy perspective, increasing access to safe abortion in favor over unsafe abortion is the single most important factor in saving lives and societal costs, and is more influential than the actual choice of safe abortion modality.

  2. Mid-Atomic-Number Cylindrical Wire Array Precursor Plasma Studies on Zebra

    DOE PAGES

    Stafford, A; Safronova, A. S.; Kantsyrev, V. L.; ...

    2014-12-30

    The precursor plasmas from low wire number cylindrical wire arrays (CWAs) were previously shown to radiate at temperatures >300 eV for Ni-60 (94% Cu and 6% Ni) wires in experiments on the 1-MA Zebra generator. Continued research into precursor plasmas has studied additional midatomic-number materials including Cu and Alumel (95% Ni, 2% Al, 2% Mn, and 1% Si) to determine if the >300 eV temperatures are common for midatomic-number materials. Additionally, current scaling effects were observed by performing CWA precursor experiments at an increased current of 1.5 MA using a load current multiplier. Our results show an increase in amore » linear radiation yield of ~50% (16 versus 10 kJ/cm) for the experiments at increased current. However, plasma conditions inferred through the modeling of X-ray time-gated spectra are very similar for the precursor plasma in both current conditions.« less

  3. MACRORESULTS THROUGH MICROARRAYS

    EPA Science Inventory

    The third enactment of Cambridge Healthtech Institute's "Macroresults through Macroarrays" meeting was held in Boston, MA, from April 29th-May 1st, 2002. The subtheme of this year's meeting was "advancing drug discovery," a widely touted application for array technology. The agen...

  4. Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery

    PubMed Central

    Li, Jiyu; Liu, Bin; Zhou, Yingying; Chen, Zhipeng; Jiang, Lelun; Yuan, Wei; Liang, Liang

    2017-01-01

    Microneedle arrays (MA) have been extensively investigated in recent decades for transdermal drug delivery due to their pain-free delivery, minimal skin trauma, and reduced risk of infection. However, porous MA received relatively less attention due to their complex fabrication process and ease of fracturing. Here, we present a titanium porous microneedle array (TPMA) fabricated by modified metal injection molding (MIM) technology. The sintering process is simple and suitable for mass production. TPMA was sintered at a sintering temperature of 1250°C for 2 h. The porosity of TPMA was approximately 30.1% and its average pore diameter was about 1.3 μm. The elements distributed on the surface of TPMA were only Ti and O, which may guarantee the biocompatibility of TPMA. TPMA could easily penetrate the skin of a human forearm without fracture. TPMA could diffuse dry Rhodamine B stored in micropores into rabbit skin. The cumulative permeated flux of calcein across TPMA with punctured skin was 27 times greater than that across intact skin. Thus, TPMA can continually and efficiently deliver a liquid drug through open micropores in skin. PMID:28187179

  5. Fully transparent conformal organic thin-film transistor array and its application as LED front driving.

    PubMed

    Cui, Nan; Ren, Hang; Tang, Qingxin; Zhao, Xiaoli; Tong, Yanhong; Hu, Wenping; Liu, Yichun

    2018-02-22

    A fully transparent conformal organic thin-film field-effect transistor array is demonstrated based on a photolithography-compatible ultrathin metallic grid gate electrode and a solution-processed C 8 -BTBT film. The resulting organic field-effect transistor array exhibits a high optical transparency of >80% over the visible spectrum, mobility up to 2 cm 2 V -1 s -1 , on/off ratio of 10 5 -10 6 , switching current of >0.1 mA, and excellent light stability. The transparent conformal transistor array is demonstrated to adhere well to flat and curved LEDs as front driving. These results present promising applications of the solution-processed wide-bandgap organic semiconductor thin films in future large-scale transparent conformal active-matrix displays.

  6. Advanced Query and Data Mining Capabilities for MaROS

    NASA Technical Reports Server (NTRS)

    Wang, Paul; Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Hy, Franklin H.

    2013-01-01

    The Mars Relay Operational Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay network. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. As part of MaROS, the innovators have developed and implemented a feature set that operates on several levels of the software architecture. This new feature is an advanced querying capability through either the Web-based user interface, or through a back-end REST interface to access all of the data gathered from the network. This software is not meant to replace the REST interface, but to augment and expand the range of available data. The current REST interface provides specific data that is used by the MaROS Web application to display and visualize the information; however, the returned information from the REST interface has typically been pre-processed to return only a subset of the entire information within the repository, particularly only the information that is of interest to the GUI (graphical user interface). The new, advanced query and data mining capabilities allow users to retrieve the raw data and/or to perform their own data processing. The query language used to access the repository is a restricted subset of the structured query language (SQL) that can be built safely from the Web user interface, or entered as freeform SQL by a user. The results are returned in a CSV (Comma Separated Values) format for easy exporting to third party tools and applications that can be used for data mining or user-defined visualization and interpretation. This is the first time that a service is capable of providing access to all cross-project relay data from a single Web resource. Because MaROS contains the data for a variety of missions from the Mars network, which span both NASA and ESA, the software also establishes an access control list (ACL) on each data record in the database repository to enforce user access permissions through a multilayered approach.

  7. Improving the optical performance of InGaN light-emitting diodes by altering light reflection and refraction with triangular air prism arrays.

    PubMed

    Kang, Ji Hye; Kim, Hyung Gu; Chandramohan, S; Kim, Hyun Kyu; Kim, Hee Yun; Ryu, Jae Hyoung; Park, Young Jae; Beak, Yun Seon; Lee, Jeong-Sik; Park, Joong Seo; Lysak, Volodymyr V; Hong, Chang-Hee

    2012-01-01

    The effect of triangular air prism (TAP) arrays with different distance-to-width (d/w) ratios on the enhancement of light extraction efficiency (LEE) of InGaN light-emitting diodes (LEDs) is investigated. The TAP arrays embedded at the sapphire/GaN interface act as light reflectors and refractors, and thereby improve the light output power due to the redirection of light into escape cones on both the front and back sides of the LED. Enhancement in radiometric power as high as 117% and far-field angle as low as 129° are realized with a compact arrangement of TAP arrays compared with that of a conventional LED made without TAP arrays under an injection current of 20 mA. © 2012 Optical Society of America

  8. Single-Cell Detection and Collection of Persister Bacteria in a Directly Accessible Femtoliter Droplet Array.

    PubMed

    Iino, Ryota; Sakakihara, Shouichi; Matsumoto, Yoshimi; Nishino, Kunihiko

    2016-01-01

    A directly accessible femtoliter droplet array as a platform for single-cell detection and collection of persister bacteria is described. Device microfabrication, femtoliter droplet array formation and concomitant enclosure of single cells, long-term culture and observation of single cells in droplets, and collection of identified persisters from single droplets are described in detail.

  9. Manycore Performance-Portability: Kokkos Multidimensional Array Library

    DOE PAGES

    Edwards, H. Carter; Sunderland, Daniel; Porter, Vicki; ...

    2012-01-01

    Large, complex scientific and engineering application code have a significant investment in computational kernels to implement their mathematical models. Porting these computational kernels to the collection of modern manycore accelerator devices is a major challenge in that these devices have diverse programming models, application programming interfaces (APIs), and performance requirements. The Kokkos Array programming model provides library-based approach to implement computational kernels that are performance-portable to CPU-multicore and GPGPU accelerator devices. This programming model is based upon three fundamental concepts: (1) manycore compute devices each with its own memory space, (2) data parallel kernels and (3) multidimensional arrays. Kernel executionmore » performance is, especially for NVIDIA® devices, extremely dependent on data access patterns. Optimal data access pattern can be different for different manycore devices – potentially leading to different implementations of computational kernels specialized for different devices. The Kokkos Array programming model supports performance-portable kernels by (1) separating data access patterns from computational kernels through a multidimensional array API and (2) introduce device-specific data access mappings when a kernel is compiled. An implementation of Kokkos Array is available through Trilinos [Trilinos website, http://trilinos.sandia.gov/, August 2011].« less

  10. Striped tertiary storage arrays

    NASA Technical Reports Server (NTRS)

    Drapeau, Ann L.

    1993-01-01

    Data stripping is a technique for increasing the throughput and reducing the response time of large access to a storage system. In striped magnetic or optical disk arrays, a single file is striped or interleaved across several disks; in a striped tape system, files are interleaved across tape cartridges. Because a striped file can be accessed by several disk drives or tape recorders in parallel, the sustained bandwidth to the file is greater than in non-striped systems, where access to the file are restricted to a single device. It is argued that applying striping to tertiary storage systems will provide needed performance and reliability benefits. The performance benefits of striping for applications using large tertiary storage systems is discussed. It will introduce commonly available tape drives and libraries, and discuss their performance limitations, especially focusing on the long latency of tape accesses. This section will also describe an event-driven tertiary storage array simulator that is being used to understand the best ways of configuring these storage arrays. The reliability problems of magnetic tape devices are discussed, and plans for modeling the overall reliability of striped tertiary storage arrays to identify the amount of error correction required are described. Finally, work being done by other members of the Sequoia group to address latency of accesses, optimizing tertiary storage arrays that perform mostly writes, and compression is discussed.

  11. Efficient Memory Access with NumPy Global Arrays using Local Memory Access

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daily, Jeffrey A.; Berghofer, Dan C.

    This paper discusses the work completed working with Global Arrays of data on distributed multi-computer systems and improving their performance. The tasks completed were done at Pacific Northwest National Laboratory in the Science Undergrad Laboratory Internship program in the summer of 2013 for the Data Intensive Computing Group in the Fundamental and Computational Sciences DIrectorate. This work was done on the Global Arrays Toolkit developed by this group. This toolkit is an interface for programmers to more easily create arrays of data on networks of computers. This is useful because scientific computation is often done on large amounts of datamore » sometimes so large that individual computers cannot hold all of it. This data is held in array form and can best be processed on supercomputers which often consist of a network of individual computers doing their computation in parallel. One major challenge for this sort of programming is that operations on arrays on multiple computers is very complex and an interface is needed so that these arrays seem like they are on a single computer. This is what global arrays does. The work done here is to use more efficient operations on that data that requires less copying of data to be completed. This saves a lot of time because copying data on many different computers is time intensive. The way this challenge was solved is when data to be operated on with binary operations are on the same computer, they are not copied when they are accessed. When they are on separate computers, only one set is copied when accessed. This saves time because of less copying done although more data access operations were done.« less

  12. Medical abortion: understanding perspectives of rural and marginalized women from rural South India.

    PubMed

    Sri, B Subha; Ravindran, T K Sundari

    2012-09-01

    To understand how rural and other groups of marginalized women define safe abortion; their perspectives and concerns regarding medical abortion (MA); and what factors affect their access to safe abortion. Focus group discussions were held with various groups of rural and marginalized women in Tamil Nadu to understand their perspectives and concerns on abortion, especially MA. Nearly a decade after mifepristone was approved for abortion in India, most study participants had never heard of MA. When they learned of the method, most preferred it over other methods of abortion. The women also had questions and concerns about the method and recommendations on how services should be provided. Their definition of a "safe abortion" included criteria beyond medical safety. They placed a high priority on "social safety," including confidentiality and privacy. In their view, factors affecting access to safe abortion and choice of provider included cost, assurance of secrecy, promptness of service provision, and absence of provider gatekeeping and provider-imposed conditions for receiving services. Women's preference for MA shows the potential of this technology to address the problem of unsafe abortion in India. Women need better access to information and services to realize this potential, however. Women's preferences regarding information dissemination and service provision need to be taken into account if policies and programs are to be truly responsive to the needs of marginalized women. Copyright © 2012. Published by Elsevier Ireland Ltd.

  13. Fabrication of Micro-Needle Electrodes for Bio-Signal Recording by a Magnetization-Induced Self-Assembly Method

    PubMed Central

    Chen, Keyun; Ren, Lei; Chen, Zhipeng; Pan, Chengfeng; Zhou, Wei; Jiang, Lelun

    2016-01-01

    Micro-needle electrodes (MEs) have attracted more and more attention for monitoring physiological electrical signals, including electrode-skin interface impedance (EII), electromyography (EMG) and electrocardiography (ECG) recording. A magnetization-induced self-assembling method (MSM) was developed to fabricate a microneedle array (MA). A MA coated with Ti/Au film was assembled as a ME. The fracture and insertion properties of ME were tested by experiments. The bio-signal recording performance of the ME was measured and compared with a typical commercial wet electrode (Ag/AgCl electrode). The results show that the MA self-assembled from the magnetic droplet array under the sum of gravitational surface tension and magnetic potential energies. The ME had good toughness and could easily pierce rabbit skin without being broken or buckling. When the compression force applied on the ME was larger than 2 N, ME could stably record EII, which was a lower value than that measured by Ag/AgCl electrodes. EMG signals collected by ME varied along with the contraction of biceps brachii muscle. ME could record static ECG signals with a larger amplitude and dynamic ECG signals with more distinguishable features in comparison with a Ag/AgCl electrode, therefore, ME is an alternative electrode for bio-signal monitoring in some specific situations. PMID:27657072

  14. Planning Design and Maintenance of Pedestrian Facilities

    DOT National Transportation Integrated Search

    1989-03-01

    Pedestrian safety and accessibility has long been a concern to Federal, State, and local agencies. The result has been a wide diversity of published reports, recommended practices and changes in accessibility standards for the planning, design and ma...

  15. The CHARA Array Database

    NASA Astrophysics Data System (ADS)

    Jones, Jeremy; Schaefer, Gail; ten Brummelaar, Theo; Gies, Douglas; Farrington, Christopher

    2018-01-01

    We are building a searchable database for the CHARA Array data archive. The Array consists of six telescopes linked together as an interferometer, providing sub-milliarcsecond resolution in the optical and near-infrared. The Array enables a variety of scientific studies, including measuring stellar angular diameters, imaging stellar shapes and surface features, mapping the orbits of close binary companions, and resolving circumstellar environments. This database is one component of an NSF/MSIP funded program to provide open access to the CHARA Array to the broader astronomical community. This archive goes back to 2004 and covers all the beam combiners on the Array. We discuss the current status of and future plans for the public database, and give directions on how to access it.

  16. All-MOCVD-grown BH laser on P-InP substrates

    NASA Astrophysics Data System (ADS)

    Nishimura, Tadashi; Ishimura, E.; Nakajima, Yasuo; Tada, Hitoshi; Kimura, T.; Ohkura, Y.; Goto, Katsuhiko; Omura, Etsuji; Aiga, Masao

    1993-07-01

    A very low cw threshold current of 2.5 mA ( 25 degree(s)C) and 8.0 mA ( 80 degree(s)C) with high reliability has been realized in the all-MOCVD grown BH lasers on p-InP substrates. A strained MQW active layer of 1.3 micrometers wavelength and the precise carrier confinement buried structure by MOCVD is employed for the BH lasers. The excellent potential of long lifetime of the all-MOCVD grown laser has also been confirmed. After the high temperature and the high current (100 degree(s)C, 200 mA) aging test, no significant degradation is observed which is comparable with the well-established LPE grown lasers. The BH laser is also operating stably over 3700 hrs under the APC condition of 50 degree(s)C, 10 mW. Finally, an extremely uniform 10-element all-MOCVD grown LD array is demonstrated, which has the threshold current uniformity of 2.4 +/- 0.1 mA ( 25 degree(s)C) and 9.2 +/- 0.2 mA ( 80 degree(s)C). The growth mechanism in the MOCVD is also described.

  17. 5. SITE BUILDING 002 SCANNER BUILDING AT "A" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SITE BUILDING 002 - SCANNER BUILDING - AT "A" FACE (ON SOUTH SIDE) LOOKING DIRECTLY UP RADAR SYSTEM EMITTER/ANTENNA ARRAY FACE WITH 90MM STANDARD LENS. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  18. Multistage WDM access architecture employing cascaded AWGs

    NASA Astrophysics Data System (ADS)

    El-Nahal, F. I.; Mears, R. J.

    2009-03-01

    Here we propose passive/active arrayed waveguide gratings (AWGs) with enhanced performance for system applications mainly in novel access architectures employing cascaded AWG technology. Two technologies were considered to achieve space wavelength switching in these networks. Firstly, a passive AWG with semiconductor optical amplifiers array, and secondly, an active AWG. Active AWG is an AWG with an array of phase modulators on its arrayed-waveguides section, where a programmable linear phase-profile or a phase hologram is applied across the arrayed-waveguide section. This results in a wavelength shift at the output section of the AWG. These architectures can address up to 6912 customers employing only 24 wavelengths, coarsely separated by 1.6 nm. Simulation results obtained here demonstrate that cascaded AWGs access architectures have a great potential in future local area networks. Furthermore, they indicate for the first time that active AWGs architectures are more efficient in routing signals to the destination optical network units than passive AWG architectures.

  19. ACCESS: Higher Hopes for Boston Public School Students.

    ERIC Educational Resources Information Center

    Bigelow, Betsy

    1987-01-01

    Describes the Action Center for Education Services and Scholarship (ACCESS) program of the Boston (MA) Public Schools in collaboration with the local business community. ACCESS provides (1) counseling to help high school students apply for financial aid; and (2) grants to supplement financial aid if that is necessary to meet college costs. (PS)

  20. Portable kit for identification and detection of drugs in human urine using surface-enhanced Raman spectroscopy.

    PubMed

    Han, Zhenzhen; Liu, Honglin; Meng, Juan; Yang, Liangbao; Liu, Jing; Liu, Jinhuai

    2015-09-15

    A portable kit was demonstrated for rapid and reliable surface-enhanced Raman scattering (SERS) detection of drugs in human urine. This kit contains two sealed reagent tubes, a packet of standardized SERS substrates, and a mini Raman device. A 3 min pretreatment for separating amphetamines from human urine was developed with an extraction rate of >80% examined by ultraperformance liquid chromatography (UPLC). Simultaneously, highly reproducible two-dimensional (2D) gold nanorod (GNR) arrays were assembled by the use of methoxymercaptopoly(ethylene glycol) (mPEG-SH) capping. Thirty batches of GNR arrays produced the 1001 cm(-1) intensity of methamphetamine (MA) molecules with a relative standard deviation (RSD) of 7.9%, and a 21 × 21 μm(2) area mapping on a 2D GNR array produced a statistical RSD of <10%, implying an excellent reproducibility and uniformity. The detection limit of amphetamines in human urine was at least 0.1 ppm. Moreover, the portable kit was successfully used for detecting MA, 3,4-methylenedioxymethamphetamine (MDMA), and methcathinone (MC) in 30 volunteers' urine samples with various clinical natures, and the dual-analyte detection of MA and MDMA implied a good capability of multiplex analysis. UPLC examination and the SERS recovery test clearly indicated that our pretreatment procedure was sufficient to lower the high background signals caused by complex components in urine and demonstrated the practicability and the resistance to false positives, which is a vital problem for law enforcement applications. The excellent performance of our portable kit promises a great prospective toward a rapid, reliable, and on-spot analyzer, especially for public safety and healthcare.

  1. 10. WEST ELEVATION OF SHOWROOM ADDITION WITH ACCESS DOORS TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. WEST ELEVATION OF SHOWROOM ADDITION WITH ACCESS DOORS TO SHOP ON LOWER LEVEL. NOTE BOW SECTION OF OLD DORY BOAT USED AS STEP INTO LOWER LEVEL. - Lowell's Boat Shop, 459 Main Street, Amesbury, Essex County, MA

  2. Preconditioned wire array Z-pinches driven by a double pulse current generator

    NASA Astrophysics Data System (ADS)

    Wu, Jian; Lu, Yihan; Sun, Fengju; Li, Xingwen; Jiang, Xiaofeng; Wang, Zhiguo; Zhang, Daoyuan; Qiu, Aici; Lebedev, Sergey

    2018-07-01

    Suppression of the core-corona structure and wire ablation in wire array Z-pinches is investigated using a novel double pulse current generator ‘Qin-1’ facility. The ‘Qin-1’ facility allows coupling a ∼10 kA 20 ns prepulse generator with a ∼0.8 MA 160 ns main current generator. The tailored prepulse current preheats wires to a gaseous state and the time interval between the prepulse and the main current pulse allows formation of a more uniform mass distribution for the implosion. The implosion of a gasified two aluminum-wire array showed no ablation phase and allowed all array mass to participate in the implosion. The initial perturbations formed from the inhomogeneous ablation were suppressed, however, the magneto Rayleigh–Taylor (MRT) instability during the implosion was still significant and further researches on the generation and development of the MRT instabilities of this gasified wire array are needed.

  3. T-Nb2O5 quantum dots prepared by electrodeposition for fast Li ion intercalation/deintercalation

    NASA Astrophysics Data System (ADS)

    Zhao, Guangyu; Ye, Chen; Zhang, Li; Li, Changle; Sun, Kening

    2017-05-01

    T-Nb2O5 quantum dots were electrodeposited on Ti nanorod arrays to prepare Ti@T-Nb2O5 core-shell array electrodes. The particle size of T-Nb2O5 could be manipulated by adjusting the depositing current density, and quantum dots several nanometers in size could be obtained at a deposition current of 6 mA cm-2. Benefiting from the ultra-small particle size of T-Nb2O5 and the array structure, Ti@T-Nb2O5 nanorod arrays exhibited good rate capability and durability when used as self-supported Li ion battery anodes. The arrays possessed capacities of 350 and 70 mAh g-1 at rate currents of 0.06 and 30 A g-1, respectively. Furthermore, the electrodes maintained 500 cycles without obvious decay at a high rate current of 30 A g-1.

  4. Vibration energy harvester with sustainable power based on a single-crystal piezoelectric cantilever array.

    PubMed

    Kim, Moonkeun; Lee, Sang-Kyun; Ham, Yong-Hyun; Yang, Yil Suk; Kwon, Jong-Kee; Kwon, Kwang-Ho

    2012-08-01

    We designed and fabricated a bimorph cantilever array for sustainable power with an integrated Cu proof mass to obtain additional power and current. We fabricated a cantilever system using single-crystal piezoelectric material and compared the calculations for single and arrayed cantilevers to those obtained experimentally. The vibration energy harvester had resonant frequencies of 60.4 and 63.2 Hz for short and open circuits, respectively. The damping ratio and quality factor of the cantilever device were 0.012 and 41.66, respectively. The resonant frequency at maximum average power was 60.8 Hz. The current and highest average power of the harvester array were found to be 0.728 mA and 1.61 mW, respectively. The sustainable maximum power was obtained after slightly shifting the short-circuit frequency. In order to improve the current and power using an array of cantilevers, we also performed energy conversion experiments.

  5. 6. SITE BUILDING 002 SCANNER BUILDING AT "A" ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SITE BUILDING 002 - SCANNER BUILDING - AT "A" FACE (ON SOUTH SIDE) LOOKING DIRECTLY UP RADAR SYSTEM EMITTER/ANTENNA ARRAY FACE WITH 65MM WIDE ANGLE LENS. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  6. Freestanding eggshell membrane-based electrodes for high-performance supercapacitors and oxygen evolution reaction

    NASA Astrophysics Data System (ADS)

    Geng, Jing; Wu, Hao; Al-Enizi, Abdullah M.; Elzatahry, Ahmed A.; Zheng, Gengfeng

    2015-08-01

    A type of freestanding, light-weight eggshell membrane-based electrode is demonstrated for supercapacitors and for oxygen evolution reaction (OER) catalysis. As a widely available daily waste, eggshell membranes have unique porous three-dimensional grid-like fibrous structures with relatively high surface area and abundant macropores, allowing for effective conjugation of carbon nanotubes and growth of NiCo2O4 nanowire arrays, an effective supercapacitor material and OER catalyst. The three-dimensional fibrous eggshell membrane frameworks with carbon nanotubes offer efficient pathways for charge transport, and the macropores between adjacent fibers are fully accessible for electrolytes and bubble evolution. As a supercapacitor, the eggshell membrane/carbon nanotube/NiCo2O4 electrode shows high specific capacitances at current densities from 1 to 20 A g-1, with excellent capacitance retention (>90%) at 10 A g-1 for over 10 000 cycles. When employed as an OER catalyst, this eggshell membrane-based electrode exhibits an OER onset potential of 1.53 V vs. the reversible hydrogen electrode (RHE), and a stable catalytic current density of 20 mA cm-2 at 1.65 V vs. the RHE.A type of freestanding, light-weight eggshell membrane-based electrode is demonstrated for supercapacitors and for oxygen evolution reaction (OER) catalysis. As a widely available daily waste, eggshell membranes have unique porous three-dimensional grid-like fibrous structures with relatively high surface area and abundant macropores, allowing for effective conjugation of carbon nanotubes and growth of NiCo2O4 nanowire arrays, an effective supercapacitor material and OER catalyst. The three-dimensional fibrous eggshell membrane frameworks with carbon nanotubes offer efficient pathways for charge transport, and the macropores between adjacent fibers are fully accessible for electrolytes and bubble evolution. As a supercapacitor, the eggshell membrane/carbon nanotube/NiCo2O4 electrode shows high specific capacitances at current densities from 1 to 20 A g-1, with excellent capacitance retention (>90%) at 10 A g-1 for over 10 000 cycles. When employed as an OER catalyst, this eggshell membrane-based electrode exhibits an OER onset potential of 1.53 V vs. the reversible hydrogen electrode (RHE), and a stable catalytic current density of 20 mA cm-2 at 1.65 V vs. the RHE. Electronic supplementary information (ESI) available: Supporting figures, with additional SEM images, EDS spectra, N2 sorption isotherms, charge-discharge curves, cycling performance, Ragone plot, Nyquist plots and linear scan voltammogram plots. See DOI: 10.1039/c5nr04603c

  7. High-performance supercapacitor and lithium-ion battery based on 3D hierarchical NH4F-induced nickel cobaltate nanosheet-nanowire cluster arrays as self-supported electrodes.

    PubMed

    Chen, Yuejiao; Qu, Baihua; Hu, Lingling; Xu, Zhi; Li, Qiuhong; Wang, Taihong

    2013-10-21

    A facile hydrothermal method is developed for large-scale production of three-dimensional (3D) hierarchical porous nickel cobaltate nanowire cluster arrays derived from nanosheet arrays with robust adhesion on Ni foam. Based on the morphology evolution upon reaction time, a possible formation process is proposed. The role of NH4F in formation of the structure has also been investigated based on different NH4F amounts. This unique structure significantly enhances the electroactive surface areas of the NiCo2O4 arrays, leading to better interfacial/chemical distributions at the nanoscale, fast ion and electron transfer and good strain accommodation. Thus, when it is used for supercapacitor testing, a specific capacitance of 1069 F g(-1) at a very high current density of 100 A g(-1) was obtained. Even after more than 10,000 cycles at various large current densities, a capacitance of 2000 F g(-1) at 10 A g(-1) with 93.8% retention can be achieved. It also exhibits a high-power density (26.1 kW kg(-1)) at a discharge current density of 80 A g(-1). When used as an anode material for lithium-ion batteries (LIBs), it presents a high reversible capacity of 976 mA h g(-1) at a rate of 200 mA g(-1) with good cycling stability and rate capability. This array material is rarely used as an anode material. Our results show that this unique 3D hierarchical porous nickel cobaltite is promising for electrochemical energy applications.

  8. Hierarchical Ni0.54Co0.46O2 nanowire and nanosheet arrays grown on carbon fiber cloth for high-performance supercapacitors

    NASA Astrophysics Data System (ADS)

    Jiang, Yuanzhi; Zhang, Lijuan; Zhang, Hang; Zhang, Cui; Liu, Shuangxi

    2016-10-01

    Hierarchical Ni0.54Co0.46O2 architectures composed by nanowires or nanosheets were successfully grown on bio-mass carbon fiber cloth (CFC) by hydrothermal method. The morphology of Ni0.54Co0.46O2 can be effectively controlled by using different precipitators. The structural effects of the two kinds of morphologies were researched. the results suggest that the Ni0.54Co0.46O2 nanosheet arrays grown on CFC (NCO-NSs/CFC) shows a higher Faradaic areal capacity of 438 μAh cm-2 (238.1 mAh g-1) at a current density of 1 mA cm-2 and still about 90.3% initial capacity retention even at the high current density of 50 mA cm-2. Moreover, an all-solid-state flexible symmetric supercapacitor device has been successfully assembled. The optimized device delivers superior electrochemical performance with an outstanding energy density of 92.4 Wh kg-1 at a power density of 207.2 W kg-1. Such hierarchical nanostructure composed by well-aligned uniform Ni0.54Co0.46O2 nanosheet arrays grown on bio-mass carbon fiber cloth might hold great promise as battery-type electrode material for high-performance supercapacitor.

  9. Spinel FeCo2S4 nanoflower arrays grown on Ni foam as novel binder-free electrodes for long-cycle-life supercapacitors

    NASA Astrophysics Data System (ADS)

    Deng, Cuifen; Yang, Lishan; Yang, Chunming; Shen, Ping; Zhao, Liping; Wang, Zhiyu; Wang, Chunhui; Li, Junhua; Qian, Dong

    2018-01-01

    Spinel FeCo2S4 nanoflower arrays grown on Ni foam (FeCo2S4@Ni) have been successfully fabricated via a facile hydrothermal sulfurization of the corresponding FeCo2O4 precursor. The results of X-ray diffraction and X-ray photoelectron spectroscopy characterizations affirm that partial Co2+/Co3+ ions in Co3S4 have been substituted by Fe2+/Fe3+ ions to form FeCo2S4. The obtained FeCo2S4@Ni exhibits an ultrahigh specific capacitance (1644.07 mF cm-2 at 50 mA cm-2) and a supreme cycling stability (∼100% after 10,000 cycles at 50 mA cm-2) as binder-free electrodes for supercapacitors. The cycling stability of the fabricated product is the highest among the documented ternary metallic sulfides so far. The excellent supercapacitive performance of FeCo2S4@Ni emanates from the unique architectures of Fe2Co2S4 nanoflower arrays constituted by ultrathin nanoflakes, three-dimensional porous and conductive Ni foam, and solid skeleton of Ni foam for robust connections to the Fe2Co2S4.

  10. Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults

    USDA-ARS?s Scientific Manuscript database

    Strawberries are considered a functional food due to the presence of a wide array of nutrients and phytochemicals including polyphenols such as anthocyanins, procyanidins and ellagitannins. These polyphenols are absorbed and metabolized to various phenolic metabolites/conjugates in the body which ma...

  11. An Optimum Space-to-Ground Communication Concept for CubeSat Platform Utilizing NASA Space Network and Near Earth Network

    NASA Technical Reports Server (NTRS)

    Wong, Yen F.; Kegege, Obadiah; Schaire, Scott H.; Bussey, George; Altunc, Serhat; Zhang, Yuwen; Patel Chitra

    2016-01-01

    National Aeronautics and Space Administration (NASA) CubeSat missions are expected to grow rapidly in the next decade. Higher data rate CubeSats are transitioning away from Amateur Radio bands to higher frequency bands. A high-level communication architecture for future space-to-ground CubeSat communication was proposed within NASA Goddard Space Flight Center. This architecture addresses CubeSat direct-to-ground communication, CubeSat to Tracking Data Relay Satellite System (TDRSS) communication, CubeSat constellation with Mothership direct-to-ground communication, and CubeSat Constellation with Mothership communication through K-Band Single Access (KSA). A study has been performed to explore this communication architecture, through simulations, analyses, and identifying technologies, to develop the optimum communication concepts for CubeSat communications. This paper presents details of the simulation and analysis that include CubeSat swarm, daughter ship/mother ship constellation, Near Earth Network (NEN) S and X-band direct to ground link, TDRSS Multiple Access (MA) array vs Single Access mode, notional transceiver/antenna configurations, ground asset configurations and Code Division Multiple Access (CDMA) signal trades for daughter ship/mother ship CubeSat constellation inter-satellite cross link. Results of space science X-band 10 MHz maximum achievable data rate study are summarized. CubeSat NEN Ka-Band end-to-end communication analysis is provided. Current CubeSat communication technologies capabilities are presented. Compatibility test of the CubeSat transceiver through NEN and SN is discussed. Based on the analyses, signal trade studies and technology assessments, the desired CubeSat transceiver features and operation concepts for future CubeSat end-to-end communications are derived.

  12. An Optimum Space-to-Ground Communication Concept for CubeSat Platform Utilizing NASA Space Network and Near Earth Network

    NASA Technical Reports Server (NTRS)

    Wong, Yen F.; Kegege, Obadiah; Schaire, Scott H.; Bussey, George; Altunc, Serhat; Zhang, Yuwen; Patel, Chitra

    2016-01-01

    National Aeronautics and Space Administration (NASA) CubeSat missions are expected to grow rapidly in the next decade. Higher data rate CubeSats are transitioning away from Amateur Radio bands to higher frequency bands. A high-level communication architecture for future space-to-ground CubeSat communication was proposed within NASA Goddard Space Flight Center. This architecture addresses CubeSat direct-to-ground communication, CubeSat to Tracking Data Relay Satellite System (TDRSS) communication, CubeSat constellation with Mothership direct-to-ground communication, and CubeSat Constellation with Mothership communication through K-Band Single Access (KSA).A Study has been performed to explore this communication architecture, through simulations, analyses, and identifying technologies, to develop the optimum communication concepts for CubeSat communications. This paper will present details of the simulation and analysis that include CubeSat swarm, daughter shipmother ship constellation, Near Earth Network (NEN) S and X-band direct to ground link, TDRS Multiple Access (MA) array vs Single Access mode, notional transceiverantenna configurations, ground asset configurations and Code Division Multiple Access (CDMA) signal trades for daughter mother CubeSat constellation inter-satellite crosslink. Results of Space Science X-band 10 MHz maximum achievable data rate study will be summarized. Assessment of Technology Readiness Level (TRL) of current CubeSat communication technologies capabilities will be presented. Compatibility test of the CubeSat transceiver through NEN and Space Network (SN) will be discussed. Based on the analyses, signal trade studies and technology assessments, the functional design and performance requirements as well as operation concepts for future CubeSat end-to-end communications will be derived.

  13. Safety of the Pandemic H1N1 Influenza Vaccine among Pregnant U.S. Military Women and Their Newborns

    DTIC Science & Technology

    2013-03-01

    copyediting. The authors appreciate the support of Eileen Hruska and the Defense Man- power Data Center, Seaside, California, with vaccine data access and...e33–40. 16. Ryan MA, Pershyn-Kisor MA, Honner WK, Smith TC, Reed RJ, Gray GC. The Department of Defense Birth Defects Registry: overview of a new

  14. PoMaMo--a comprehensive database for potato genome data.

    PubMed

    Meyer, Svenja; Nagel, Axel; Gebhardt, Christiane

    2005-01-01

    A database for potato genome data (PoMaMo, Potato Maps and More) was established. The database contains molecular maps of all twelve potato chromosomes with about 1000 mapped elements, sequence data, putative gene functions, results from BLAST analysis, SNP and InDel information from different diploid and tetraploid potato genotypes, publication references, links to other public databases like GenBank (http://www.ncbi.nlm.nih.gov/) or SGN (Solanaceae Genomics Network, http://www.sgn.cornell.edu/), etc. Flexible search and data visualization interfaces enable easy access to the data via internet (https://gabi.rzpd.de/PoMaMo.html). The Java servlet tool YAMB (Yet Another Map Browser) was designed to interactively display chromosomal maps. Maps can be zoomed in and out, and detailed information about mapped elements can be obtained by clicking on an element of interest. The GreenCards interface allows a text-based data search by marker-, sequence- or genotype name, by sequence accession number, gene function, BLAST Hit or publication reference. The PoMaMo database is a comprehensive database for different potato genome data, and to date the only database containing SNP and InDel data from diploid and tetraploid potato genotypes.

  15. PoMaMo—a comprehensive database for potato genome data

    PubMed Central

    Meyer, Svenja; Nagel, Axel; Gebhardt, Christiane

    2005-01-01

    A database for potato genome data (PoMaMo, Potato Maps and More) was established. The database contains molecular maps of all twelve potato chromosomes with about 1000 mapped elements, sequence data, putative gene functions, results from BLAST analysis, SNP and InDel information from different diploid and tetraploid potato genotypes, publication references, links to other public databases like GenBank (http://www.ncbi.nlm.nih.gov/) or SGN (Solanaceae Genomics Network, http://www.sgn.cornell.edu/), etc. Flexible search and data visualization interfaces enable easy access to the data via internet (https://gabi.rzpd.de/PoMaMo.html). The Java servlet tool YAMB (Yet Another Map Browser) was designed to interactively display chromosomal maps. Maps can be zoomed in and out, and detailed information about mapped elements can be obtained by clicking on an element of interest. The GreenCards interface allows a text-based data search by marker-, sequence- or genotype name, by sequence accession number, gene function, BLAST Hit or publication reference. The PoMaMo database is a comprehensive database for different potato genome data, and to date the only database containing SNP and InDel data from diploid and tetraploid potato genotypes. PMID:15608284

  16. Wire Array Z-pinches on Sphinx Machine: Experimental Results and Relevant Points of Microsecond Implosion Physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Calamy, H.; Hamann, F.; Lassalle, F.

    Centre d'Etudes de Gramat (France) has developed an efficient long implosion time (800 ns) Aluminum plasma radiation source (PRS). Based on the LTD technology, the SPHINX facility is developed as a 1-3MJ, 1{mu}s rise time, 4-10 MA current driver. In this paper, it was used in 1MJ, 4MA configuration to drive Aluminum nested wire arrays Z-pinches with K-shell yield up to 20 kJ and a FWHM of the x-ray pulse of about 50 ns. We present latest SPHINX experiments and some of the main physic issues of the microsecond regime. Experimental setup and results are described with the aim ofmore » giving trends that have been obtained. The main features of microsecond implosion of wire arrays can be analyzed thanks to same methods and theories as used for faster Z-pinches. The effect of load polarity was examined. The stability of the implosion , one of the critical point of microsecond wire arrays due to the load dimensions imposed by the time scale, is tackled. A simple scaling from 100 ns Z-pinch results to 800 ns ones gives good results and the use of nested arrays improves dramatically the implosion quality and the Kshell yield of the load. However, additional effects such as the impact of the return current can geometry on the implosion have to be taken into account on our loads. Axial inhomogeneity of the implosion the origin of which is not yet well understood occurs in some shots and impacts the radiation output. The shape of the radiative pulse is discussed and compared with the homogeneity of the implosion. Numerical 2D R-Z and R-{theta} simulations are used to highlight some experimental results and understand the plasma conditions during these microsecond wire arrays implosions.« less

  17. Wire Array Z-pinches on Sphinx Machine: Experimental Results and Relevant Points of Microsecond Implosion Physics

    NASA Astrophysics Data System (ADS)

    Calamy, H.; Hamann, F.; Lassalle, F.; Bayol, F.; Mangeant, C.; Morell, A.; Huet, D.; Bedoch, J. P.; Chittenden, J. P.; Lebedev, S. V.; Jennings, C. A.; Bland, S. N.

    2006-01-01

    Centre d'Etudes de Gramat (France) has developed an efficient long implosion time (800 ns) Aluminum plasma radiation source (PRS). Based on the LTD technology, the SPHINX facility is developed as a 1-3MJ, 1μs rise time, 4-10 MA current driver. In this paper, it was used in 1MJ, 4MA configuration to drive Aluminum nested wire arrays Z-pinches with K-shell yield up to 20 kJ and a FWHM of the x-ray pulse of about 50 ns. We present latest SPHINX experiments and some of the main physic issues of the microsecond regime. Experimental setup and results are described with the aim of giving trends that have been obtained. The main features of microsecond implosion of wire arrays can be analyzed thanks to same methods and theories as used for faster Z-pinches. The effect of load polarity was examined. The stability of the implosion , one of the critical point of microsecond wire arrays due to the load dimensions imposed by the time scale, is tackled. A simple scaling from 100 ns Z-pinch results to 800 ns ones gives good results and the use of nested arrays improves dramatically the implosion quality and the Kshell yield of the load. However, additional effects such as the impact of the return current can geometry on the implosion have to be taken into account on our loads. Axial inhomogeneity of the implosion the origin of which is not yet well understood occurs in some shots and impacts the radiation output. The shape of the radiative pulse is discussed and compared with the homogeneity of the implosion. Numerical 2D R-Z and R-θ simulations are used to highlight some experimental results and understand the plasma conditions during these microsecond wire arrays implosions.

  18. Nanocrystal-constructed mesoporous CoFe₂O₄ nanowire arrays aligned on flexible carbon fabric as integrated anodes with enhanced lithium storage properties.

    PubMed

    Wang, Bo; Li, Songmei; Wu, Xiaoyu; Li, Bin; Liu, Jianhua; Yu, Mei

    2015-09-07

    A novel and facile two-step strategy is successfully developed for the large-scale fabrication of hierarchical mesoporous CoFe2O4 nanowire arrays (NWAs) on flexible carbon fabric as integrated anodes for highly efficient and reversible lithium storage. The synthesis involves the co-deposition of uniform bimetallic (Co, Fe) carbonate hydroxide hydrate precursor NWAs on carbon fabric and subsequent thermal transformation to spinel CoFe2O4 without damaging the morphology. The as-prepared CoFe2O4 nanowires have unique mesoporous structures, which are constructed by many interconnected nanocrystals with sizes of about 15-20 nm. The typical size of the nanowires is in the range of 70-100 nm in width and up to several micrometers in length. Such a hybrid nanostructure electrode presented here not only simplifies electrode processing, but also promises fast electron transport/collection and ion diffusion, and withstands volume variation upon prolonged charge/discharge cycling. As a result, the binder-free CoFe2O4/carbon fabric composite exhibits a high reversible capacity of 1185.75 mA h g(-1) at a current density of 200 mA g(-1), and a superior rate capability. More importantly, a reversible capacity as high as ∼950 mA h g(-1) can be retained and there is no obvious decay after 150 cycles.

  19. Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays.

    PubMed

    Zaric, Marija; Becker, Pablo Daniel; Hervouet, Catherine; Kalcheva, Petya; Ibarzo Yus, Barbara; Cocita, Clement; O'Neill, Lauren Alexandra; Kwon, Sung-Yun; Klavinskis, Linda Sylvia

    2017-12-28

    The generation of tissue resident memory (T RM ) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delivery to the mucosae is necessary to achieve that aim. Here we characterise a novel micro-needle array (MA) delivery system fabricated to deliver a live recombinant human adenovirus type 5 vaccine vector (AdHu5) encoding HIV-1 gag. We demonstrate rapid dissolution kinetics of the microneedles in skin. Moreover, a consequence of MA vaccine cargo release was the generation of long-lived antigen-specific CD8 + T cells that accumulate in mucosal tissues, including the female genital and respiratory tract. The memory CD8 + T cell population maintained in the peripheral mucosal tissues was attributable to a MA delivered AdHu5 vaccine instructing CD8 + T cell expression of CXCR3 + , CD103 +, CD49a + , CD69 + , CD127 + homing, retention and survival markers. Furthermore, memory CD8 + T cells generated by MA immunization significantly expanded upon locally administered antigenic challenge and showed a predominant poly-functional profile producing high levels of IFNγ and Granzyme B. These data demonstrate that skin vaccine delivery using microneedle technology induces mobilization of long lived, poly-functional CD8 + T cells to peripheral tissues, phenotypically displaying hallmarks of residency and yields new insights into how to design and deliver effective vaccine candidates with properties to exert local immunosurveillance at the mucosal surfaces. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  20. Mass and Reliability Source (MaRS) Database

    NASA Technical Reports Server (NTRS)

    Valdenegro, Wladimir

    2017-01-01

    The Mass and Reliability Source (MaRS) Database consolidates components mass and reliability data for all Oribital Replacement Units (ORU) on the International Space Station (ISS) into a single database. It was created to help engineers develop a parametric model that relates hardware mass and reliability. MaRS supplies relevant failure data at the lowest possible component level while providing support for risk, reliability, and logistics analysis. Random-failure data is usually linked to the ORU assembly. MaRS uses this data to identify and display the lowest possible component failure level. As seen in Figure 1, the failure point is identified to the lowest level: Component 2.1. This is useful for efficient planning of spare supplies, supporting long duration crewed missions, allowing quicker trade studies, and streamlining diagnostic processes. MaRS is composed of information from various databases: MADS (operating hours), VMDB (indentured part lists), and ISS PART (failure data). This information is organized in Microsoft Excel and accessed through a program made in Microsoft Access (Figure 2). The focus of the Fall 2017 internship tour was to identify the components that were the root cause of failure from the given random-failure data, develop a taxonomy for the database, and attach material headings to the component list. Secondary objectives included verifying the integrity of the data in MaRS, eliminating any part discrepancies, and generating documentation for future reference. Due to the nature of the random-failure data, data mining had to be done manually without the assistance of an automated program to ensure positive identification.

  1. Health Impact Assessment(HIA)of Building Renovations at Gerena Community School, Springfield, Massachusetts

    EPA Science Inventory

    The US Environmental Protection Agency (EPA) has conducted an HIA at the German Gerena Community School in Springfield, MA. HIA is a six-step systematic process that uses an array of data sources, analytic methods and stakeholder input to determine the potential health effects of...

  2. 17. CAPE COD AIR STATION PAVE PAWS FACILITY AERIAL VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. CAPE COD AIR STATION PAVE PAWS FACILITY AERIAL VIEW WITH PROJECT NEARING COMPLETION. VIEW SHOWS "A" FACE (LEFT) AND "B" FACE OF RADAR ARRAY SYSTEM. NOTE THAT NORTH IS GENERALLY TO RIGHT OF VIEW. - Cape Cod Air Station, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  3. Optical intensity dynamics in a five-emitter semiconductor array laser

    NASA Astrophysics Data System (ADS)

    Williams, Matthew O.; Kutz, J. Nathan

    2009-06-01

    The intensity dynamics of a five-emitter laser array subject to a linearly decreasing injection current are examined numerically. We have matched the results of the numerical model to an experimental AlGaAs quantum-dot array laser and have achieved the same robust oscillatory power output with a nearly π phase shift between emitters that was observed in experiments. Due to the linearly decreasing injection current, the output power of the waveguide decreases as a function of waveguide number. For injection currents ranging from 380 to 500 mA, the oscillatory behavior persists with only a slight change in phase difference. However, the fundamental frequency of oscillation increases with injection current, and higher harmonics as well as some fine structures are produced.

  4. Milliarcsecond Astronomy with the CHARA Array

    NASA Astrophysics Data System (ADS)

    Schaefer, Gail; ten Brummelaar, Theo; Gies, Douglas; Jones, Jeremy; Farrington, Christopher

    2018-01-01

    The Center for High Angular Resolution Astronomy offers 50 nights per year of open access time at the CHARA Array. The Array consists of six telescopes linked together as an interferometer, providing sub-milliarcsecond resolution in the optical and near-infrared. The Array enables a variety of scientific studies, including measuring stellar angular diameters, imaging stellar shapes and surface features, mapping the orbits of close binary companions, and resolving circumstellar environments. The open access time is part of an NSF/MSIP funded program to open the CHARA Array to the broader astronomical community. As part of the program, we will build a searchable database for the CHARA data archive and run a series of one-day community workshops at different locations across the country to expand the user base for stellar interferometry and encourage new scientific investigations with the CHARA Array.

  5. Public health strategies for Mäori.

    PubMed

    Durie, M

    2000-06-01

    When the New Zealand Department of Public Health was established in 1900, Maöri health status was compromised to the extent that survival itself was threatened. The remarkable turnaround was unexpected and owes much to pioneer Maöri professionals, especially the first Maöri medical practitioner, Dr. Maui Pomare, who graduated in the United States in 1899. As "Medical Officer to the Maöris," and later as Minister of Health, he made major changes through a five-part strategy: recognizing Maöri community leaders as leaders in health, improving access to societal goods and services (especially housing and education), appealing to cultural practices that were linked to good health, wise use of political power, and developing a skilled Maori health workforce to complement community leadership. Although mental health disorders and lifestyle illnesses have largely replaced infectious diseases, malnutrition, and tuberculosis, Pomare's strategy has continuing relevance and warrants serious consideration as a model for health promotion.

  6. HoCaMA: Home Care Hybrid Multiagent Architecture

    NASA Astrophysics Data System (ADS)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  7. ArrayBridge: Interweaving declarative array processing with high-performance computing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xing, Haoyuan; Floratos, Sofoklis; Blanas, Spyros

    Scientists are increasingly turning to datacenter-scale computers to produce and analyze massive arrays. Despite decades of database research that extols the virtues of declarative query processing, scientists still write, debug and parallelize imperative HPC kernels even for the most mundane queries. This impedance mismatch has been partly attributed to the cumbersome data loading process; in response, the database community has proposed in situ mechanisms to access data in scientific file formats. Scientists, however, desire more than a passive access method that reads arrays from files. This paper describes ArrayBridge, a bi-directional array view mechanism for scientific file formats, that aimsmore » to make declarative array manipulations interoperable with imperative file-centric analyses. Our prototype implementation of ArrayBridge uses HDF5 as the underlying array storage library and seamlessly integrates into the SciDB open-source array database system. In addition to fast querying over external array objects, ArrayBridge produces arrays in the HDF5 file format just as easily as it can read from it. ArrayBridge also supports time travel queries from imperative kernels through the unmodified HDF5 API, and automatically deduplicates between array versions for space efficiency. Our extensive performance evaluation in NERSC, a large-scale scientific computing facility, shows that ArrayBridge exhibits statistically indistinguishable performance and I/O scalability to the native SciDB storage engine.« less

  8. The Pegasus-Upgrade Experiment

    NASA Astrophysics Data System (ADS)

    Fonck, R. J.; Bongard, M. W.; Barr, J. L.; Frerichs, H. G.; Lewicki, B. T.; Reusch, J. A.; Schmitz, O.; Winz, G. R.

    2015-11-01

    Tokamak operation at near-unity aspect ratio provides access to advanced tokamak physics at modest parameters. High plasma current is accessible at very low toroidal field. This offers H-mode performance at Te levels that allow use of electrostatic and magnetic probe arrays through the edge pedestal region into the plasma core. An upgrade to the Pegasus ST is planned to exploit these features and pursue unique studies in three areas: local measurements of pedestal and ELM dynamics at Alfvenic timescales; direct measurement of the local plasma response to application of 3D magnetic perturbations with high spectral flexibility; and extension of Local Helicity Injection for nonsolenoidal startup to NSTX-U-relevant confinement and stability regimes. Significant but relatively low-cost upgrades to the facility are proposed: a new centerstack with larger solenoid and 2x the number of toroidal field conductors; a new TF power supply and conversion of the 200 MVA OH power supply to a cascaded multilevel inverter configuration; and installation of an extensive 3D-magnetic perturbation coil system for ELM mitigation and suppression studies. The upgraded facility will provide 0.3 MA plasmas with pulse lengths of 50-100 msec flattop, aspect ratio <1.25, and toroidal field up to 0.4 T. These research activities will be integrated into related efforts on DIII-D and NSTX-U. Work supported by US DOE grant DE-FG02-96ER54375.

  9. Plasma current ramp-up by lower hybrid wave using innovative antennas on TST-2

    NASA Astrophysics Data System (ADS)

    Takase, Yuichi; Ejiri, Akira; Moeller, Charles; Roidl, Benedikt; Shinya, Takahiro; Tsujii, Naoto; Yajima, Satoru; Yamazaki, Hibiki; Kitayama, Akichika; Matsumoto, Naoki; Sato, Akito; Sonehara, Masateru; Takahashi, Wataru; Tajiri, Yoshiyuki; Takei, Yuki; Togashi, Hiro; Toida, Kazuya; Yoshida, Yusuke

    2016-10-01

    Non-inductive plasma current (Ip) ramp-up by RF power in the lower hybrid frequency range is being studied on the TST-2 spherical tokamak (R = 0.36 m, a = 0.23 m, Bt = 0.3 T, Ip = 0.1 MA). Up to 400 kW of RF power is available at a frequency of 200 MHz. An innovative antenna called the capacitively-coupled combline (CCC) antenna was developed to excite a sharp, highly directional traveling wave with the electric field polarized in the toroidal direction. It is an array of resonant circuit elements made of capacitance and inductance, coupled to neighboring elements by mutual capacitance. Two CCC antennas are installed in TST-2, a 13-element outboard-launch antenna and a 6-element top-launch antenna. The latter was installed in March 2016 to improve accessibility to the core and to achieve single-pass damping. The suspected wave power loss in the scrape-off layer plasma should also be avoided. Ip ramp-up to 25 kA has been achieved so far. An upgrade of the Bt power supply is planned to take advantage of the observed improvement of Ip ramp-up with Bt. Higher Bt for longer pulses should improve the Ip ramp-up efficiency by improving wave accessibility and by reducing prompt orbit losses of energetic electrons.

  10. Non-volatile copolymer compositions for fabricating gel element microarrays

    PubMed Central

    Golova, Julia B.; Chernov, Boris K.; Perov, Alexander N.; Reynolds, Jennifer; Linger, Yvonne L.; Kukhtin, Alexander; Chandler, Darrell P.

    2011-01-01

    By modifying polymer compositions and cross-linking reagents, we have developed a simple yet effective manufacturing strategy for copolymerized three-dimensional gel element arrays. A new gel-forming monomer (2-(hydroxyethyl) methacrylamide; HEMAA) was used that possesses low volatility and improves the stability of copolymerized gel element arrays to on-chip thermal cycling procedures relative to previously used monomers. Probe immobilization efficiency within the new polymer was 55%, equivalent to that obtained with acrylamide (AA) and methacrylamide (MA) monomers. Non-specific binding of single stranded targets was equivalent for all monomers. Increasing cross-linker chain length improved hybridization kinetics and end-point signal intensities relative to N,N-methylenebisacrylamide (Bis). The new copolymer formulation was successfully applied to a model orthopox array. Because HEMAA greatly simplifies gel element array manufacture, we expect it (in combination with new cross-linkers described herein) to find widespread application in microarray science. PMID:22033291

  11. Study of soft X-ray emission during wire array implosion under plasma focus conditions at the PF-3 facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dan’ko, S. A.; Mitrofanov, K. N., E-mail: mitrofan@triniti.ru; Krauz, V. I.

    2015-11-15

    Results of measurements of soft X-ray emission with photon energies of <1 keV under conditions of a plasma focus (PF) experiment are presented. The experiments were carried out at the world’s largest PF device—the PF-3 Filippov-type facility (I ⩽ 3 MA, T/4 ≈ 15–20 µs, W{sub 0} ⩽ 3 MJ). X-ray emission from both a discharge in pure neon and with a tungsten wire array placed on the axis of the discharge chamber was detected. The wire array imploded under the action of the electric current intercepted from the plasma current sheath of the PF discharge in neon. The measuredmore » soft X-ray powers from a conventional PF discharge in gas and a PF discharge in the presence of a wire array were compared for the first time.« less

  12. Spatiotemporal and spectral characteristics of X-ray radiation emitted by the Z-pinch during the current implosion of quasispherical multiwire arrays

    NASA Astrophysics Data System (ADS)

    Gritsuk, A. N.

    2017-12-01

    For the first time, a quasi-spherical current implosion has been experimentally realized on a multimegaampere facility with the peak current of up to 4 MA and a soft X-ray source has been created with high radiation power density on its surface of up to 3 TW/cm2. An increase in the energy density at the centre of the source of soft X-ray radiation (SXR) was experimentally observed upon compression of quasi-spherical arrays with the linear-mass profiling. In this case, the average power density on the surface of the SXR source is three times higher than for implosions of cylindrical arrays of the same mass and close values of the discharge current. Obtained experimental data are compared with the results of modelling the current implosion of multi-wire arrays performed with the help of a three-dimensional radiation-magneto-hydrodynamic code.

  13. Accessibility Limits Recall from Visual Working Memory

    ERIC Educational Resources Information Center

    Rajsic, Jason; Swan, Garrett; Wilson, Daryl E.; Pratt, Jay

    2017-01-01

    In this article, we demonstrate limitations of accessibility of information in visual working memory (VWM). Recently, cued-recall has been used to estimate the fidelity of information in VWM, where the feature of a cued object is reproduced from memory (Bays, Catalao, & Husain, 2009; Wilken & Ma, 2004; Zhang & Luck, 2008). Response…

  14. Dual-band and polarization-insensitive terahertz absorber based on fractal Koch curves

    NASA Astrophysics Data System (ADS)

    Ma, Yan-Bing; Zhang, Huai-Wu; Li, Yuan-Xun; Wang, Yi-Cheng; Lai, Wei-En; Li, Jie

    2014-05-01

    We report the design, fabrication, and characterization of a dual-band and polarization-insensitive metamaterial absorber (MA), which consists of periodically arranged fractal Koch curves acting as the top resonator array and a metallic ground plane separated by a dielectric spacer. Compared with conventional MAs, a more compact size and multi-frequency operation are achieved by using fractal geometry as the unit cell of the MA. Both the effective medium theory and the multi-reflection interference theory are employed to investigate the underlying physical mechanism of the proposed terahertz MA, and results indicate that the latter theory is not suitable for explaining the absorption mechanism in our investigated structure. Two absorption peaks are observed at 0.226 THz and 0.622 THz with absorptivities of 91.3% and 95.6% respectively and good agreements between the full-wave simulation and experimental results are achieved.

  15. 'FloraArray' for screening of specific DNA probes representing the characteristics of a certain microbial community.

    PubMed

    Yokoi, Takahide; Kaku, Yoshiko; Suzuki, Hiroyuki; Ohta, Masayuki; Ikuta, Hajime; Isaka, Kazuichi; Sumino, Tatsuo; Wagatsuma, Masako

    2007-08-01

    To investigate uncharacterized microbial communities, a custom DNA microarray named 'FloraArray' was developed for screening specific probes that would represent the characteristics of a microbial community. The array was prepared by spotting 2000 plasmid DNAs from a genomic shotgun library of a sludge sample on a DNA microarray. By comparative hybridization of the array with two different samples of genomic DNA, one from the activated sludge and the other from a nonactivated sludge sample of an anaerobic ammonium oxidation (anammox) bacterial community, specific spots were visualized as a definite fluctuating profile in an MA (differential intensity ratio vs. spot intensity) plot. About 300 spots of the array accounted for the candidate probes to represent anammox reaction of the activated sludge. After sequence analysis of the probes and examination of the results of blastn searches against the reported anammox reference sequence, complete matches were found for 161 probes (58.3%) and >90% matches were found for 242 probes (87.1%). These results demonstrate that 'FloraArray' could be a useful tool for screening specific DNA molecules of unknown microbial communities.

  16. Microfluidic separation of magnetic nanoparticles on an ordered array of magnetized micropillars

    NASA Astrophysics Data System (ADS)

    Orlandi, G.; Kuzhir, P.; Izmaylov, Y.; Alves Marins, J.; Ezzaier, H.; Robert, L.; Doutre, F.; Noblin, X.; Lomenech, C.; Bossis, G.; Meunier, A.; Sandoz, G.; Zubarev, A.

    2016-06-01

    Microfluidic separation of magnetic particles is based on their capture by magnetized microcollectors while the suspending fluid flows past the microcollectors inside a microchannel. Separation of nanoparticles is often challenging because of strong Brownian motion. Low capture efficiency of nanoparticles limits their applications in bioanalysis. However, at some conditions, magnetic nanoparticles may undergo field-induced aggregation that amplifies the magnetic attractive force proportionally to the aggregate volume and considerably increases nanoparticle capture efficiency. In this paper, we have demonstrated the role of such aggregation on an efficient capture of magnetic nanoparticles (about 80 nm in diameter) in a microfluidic channel equipped with a nickel micropillar array. This array was magnetized by an external uniform magnetic field, of intensity as low as 6-10 kA/m, and experiments were carried out at flow rates ranging between 0.3 and 30 μ L /min . Nanoparticle capture is shown to be mostly governed by the Mason number Ma, while the dipolar coupling parameter α does not exhibit a clear effect in the studied range, 1.4 < α < 4.5. The capture efficiency Λ shows a strongly decreasing Mason number behavior, Λ ∝M a-1.78 within the range 32 ≤ Ma ≤ 3250. We have proposed a simple theoretical model which considers destructible nanoparticle chains and gives the scaling behavior, Λ ∝M a-1.7 , close to the experimental findings.

  17. Smart Construction of Integrated CNTs/Li4Ti5O12 Core/Shell Arrays with Superior High-Rate Performance for Application in Lithium-Ion Batteries.

    PubMed

    Yao, Zhujun; Xia, Xinhui; Zhou, Cheng-Ao; Zhong, Yu; Wang, Yadong; Deng, Shengjue; Wang, Weiqi; Wang, Xiuli; Tu, Jiangping

    2018-03-01

    Exploring advanced high-rate anodes is of great importance for the development of next-generation high-power lithium-ion batteries (LIBs). Here, novel carbon nanotubes (CNTs)/Li 4 Ti 5 O 12 (LTO) core/shell arrays on carbon cloth (CC) as integrated high-quality anode are constructed via a facile combined chemical vapor deposition-atomic layer deposition (ALD) method. ALD-synthesized LTO is strongly anchored on the CNTs' skeleton forming core/shell structures with diameters of 70-80 nm the combined advantages including highly conductive network, large surface area, and strong adhesion are obtained in the CC-LTO@CNTs core/shell arrays. The electrochemical performance of the CC-CNTs/LTO electrode is completely studied as the anode of LIBs and it shows noticeable high-rate capability (a capacity of 169 mA h g -1 at 1 C and 112 mA h g -1 at 20 C), as well as a stable cycle life with a capacity retention of 86% after 5000 cycles at 10 C, which is much better than the CC-LTO counterpart. Meanwhile, excellent cycling stability is also demonstrated for the full cell with LiFePO 4 cathode and CC-CNTs/LTO anode (87% capacity retention after 1500 cycles at 10 C). These positive features suggest their promising application in high-power energy storage areas.

  18. MaNIDA: an operational infrastructure for shipborne data

    NASA Astrophysics Data System (ADS)

    Macario, Ana; Scientific MaNIDA Team

    2013-04-01

    The Marine Network for Integrated Data Access (MaNIDA) aims to build a sustainable e-Infrastruture to support discovery and re-use of data archived in a distributed network of data providers in Germany (see related abstracts in session ESSI1.2 and session ESSI2.2). Because one of the primary focus of MaNIDA is the underway data acquired on board of German academic research vessels, we will be addressing various issues related to cruise-level metadata, shiptrack navigation, sampling events conducted during the cruise (event logs), standardization of device-related (type, name, parameters) and place-related (gazetteer) vocabularies, QA/QC procedures (near real time and post-cruise validation, corrections, quality flags) as well as ingestion and management of contextual information (e.g. various types of cruise-related reports and project-related information). One of MaNIDA's long-term goal is to be able to offer an integrative "one-stop-shop" framework for management and access of ship-related information based on international standards and interoperability. This access framework will be freely available and is intended for scientists, funding agencies and the public. The master "catalog" we are building currently contains information from 13 German academic research vessels and respective cruises (to date ~1900 cruises with expected growing rate of ~150 cruises annually). Moreover, MaNIDA's operational infrastructure will additionally provide a direct pipeline to SeaDataNet Cruise Summary Report Inventory, among others. In this presentation, we will focus on the extensions we are currently implementing to support automated acquisition and standardized transfer of various types of data from German research vessels to hosts on land. Our concept towards nationwide common QA/QC procedures for various types of underway data (including versioning concept) and common workflows will also be presented. The "linking" of cruise-related information with quality-controlled data and data products (e.g., digital terrain models), publications, cruise-related reports, people and other contextual information will be additionally shown in the framework of a prototype for R.V. Polarstern.

  19. Field-Based Learning: The Challenge of Practising Participatory Knowledge

    ERIC Educational Resources Information Center

    Morrissey, John; Clavin, Alma; Reilly, Kathy

    2013-01-01

    In 2009, Geography at National University of Ireland, Galway, launched a new taught master's programme, the MA in Environment, Society and Development. The vision for the programme was to engage students in the analysis and critique of the array of interventionary practices of development and securitization in our contemporary world. A range of…

  20. ABC Triblock Copolymer Worms: Synthesis, Characterization, and Evaluation as Pickering Emulsifiers for Millimeter-Sized Droplets

    PubMed Central

    2016-01-01

    Polymerization-induced self-assembly (PISA) is used to prepare linear poly(glycerol monomethacrylate)–poly(2-hydroxypropyl methacrylate)–poly(benzyl methacrylate) [PGMA–PHPMA–PBzMA] triblock copolymer nano-objects in the form of a concentrated aqueous dispersion via a three-step synthesis based on reversible addition–fragmentation chain transfer (RAFT) polymerization. First, GMA is polymerized via RAFT solution polymerization in ethanol, then HPMA is polymerized via RAFT aqueous solution polymerization, and finally BzMA is polymerized via “seeded” RAFT aqueous emulsion polymerization. For certain block compositions, highly anisotropic worm-like particles are obtained, which are characterized by small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). The design rules for accessing higher order morphologies (i.e., worms or vesicles) are briefly explored. Surprisingly, vesicular morphologies cannot be accessed by targeting longer PBzMA blocks—instead, only spherical nanoparticles are formed. SAXS is used to rationalize these counterintuitive observations, which are best explained by considering subtle changes in the relative enthalpic incompatibilities between the three blocks during the growth of the PBzMA block. Finally, the PGMA–PHPMA–PBzMA worms are evaluated as Pickering emulsifiers for the stabilization of oil-in-water emulsions. Millimeter-sized oil droplets can be obtained using low-shear homogenization (hand-shaking) in the presence of 20 vol % n-dodecane. In contrast, control experiments performed using PGMA–PHPMA diblock copolymer worms indicate that these more delicate nanostructures do not survive even these mild conditions. PMID:27795581

  1. High energy density asymmetric supercapacitors with a nickel oxide nanoflake cathode and a 3D reduced graphene oxide anode

    NASA Astrophysics Data System (ADS)

    Luan, Feng; Wang, Gongming; Ling, Yichuan; Lu, Xihong; Wang, Hanyu; Tong, Yexiang; Liu, Xiao-Xia; Li, Yat

    2013-08-01

    Here we demonstrate a high energy density asymmetric supercapacitor with nickel oxide nanoflake arrays as the cathode and reduced graphene oxide as the anode. Nickel oxide nanoflake arrays were synthesized on a flexible carbon cloth substrate using a seed-mediated hydrothermal method. The reduced graphene oxide sheets were deposited on three-dimensional (3D) nickel foam by hydrothermal treatment of nickel foam in graphene oxide solution. The nanostructured electrodes provide a large effective surface area. The asymmetric supercapacitor device operates with a voltage of 1.7 V and achieved a remarkable areal capacitance of 248 mF cm-2 (specific capacitance of 50 F g-1) at a charge/discharge current density of 1 mA cm-2 and a maximum energy density of 39.9 W h kg-1 (based on the total mass of active materials of 5.0 mg). Furthermore, the device showed an excellent charge/discharge cycling performance in 1.0 M KOH electrolyte at a current density of 5 mA cm-2, with a capacitance retention of 95% after 3000 cycles.

  2. High energy density asymmetric supercapacitors with a nickel oxide nanoflake cathode and a 3D reduced graphene oxide anode.

    PubMed

    Luan, Feng; Wang, Gongming; Ling, Yichuan; Lu, Xihong; Wang, Hanyu; Tong, Yexiang; Liu, Xiao-Xia; Li, Yat

    2013-09-07

    Here we demonstrate a high energy density asymmetric supercapacitor with nickel oxide nanoflake arrays as the cathode and reduced graphene oxide as the anode. Nickel oxide nanoflake arrays were synthesized on a flexible carbon cloth substrate using a seed-mediated hydrothermal method. The reduced graphene oxide sheets were deposited on three-dimensional (3D) nickel foam by hydrothermal treatment of nickel foam in graphene oxide solution. The nanostructured electrodes provide a large effective surface area. The asymmetric supercapacitor device operates with a voltage of 1.7 V and achieved a remarkable areal capacitance of 248 mF cm(-2) (specific capacitance of 50 F g(-1)) at a charge/discharge current density of 1 mA cm(-2) and a maximum energy density of 39.9 W h kg(-1) (based on the total mass of active materials of 5.0 mg). Furthermore, the device showed an excellent charge/discharge cycling performance in 1.0 M KOH electrolyte at a current density of 5 mA cm(-2), with a capacitance retention of 95% after 3000 cycles.

  3. Carbon nanosheet frameworks derived from peat moss as high performance sodium ion battery anodes.

    PubMed

    Ding, Jia; Wang, Huanlei; Li, Zhi; Kohandehghan, Alireza; Cui, Kai; Xu, Zhanwei; Zahiri, Beniamin; Tan, Xuehai; Lotfabad, Elmira Memarzadeh; Olsen, Brian C; Mitlin, David

    2013-12-23

    We demonstrate that peat moss, a wild plant that covers 3% of the earth's surface, serves as an ideal precursor to create sodium ion battery (NIB) anodes with some of the most attractive electrochemical properties ever reported for carbonaceous materials. By inheriting the unique cellular structure of peat moss leaves, the resultant materials are composed of three-dimensional macroporous interconnected networks of carbon nanosheets (as thin as 60 nm). The peat moss tissue is highly cross-linked, being rich in lignin and hemicellulose, suppressing the nucleation of equilibrium graphite even at 1100 °C. Rather, the carbons form highly ordered pseudographitic arrays with substantially larger intergraphene spacing (0.388 nm) than graphite (c/2 = 0.3354 nm). XRD analysis demonstrates that this allows for significant Na intercalation to occur even below 0.2 V vs Na/Na(+). By also incorporating a mild (300 °C) air activation step, we introduce hierarchical micro- and mesoporosity that tremendously improves the high rate performance through facile electrolyte access and further reduced Na ion diffusion distances. The optimized structures (carbonization at 1100 °C + activation) result in a stable cycling capacity of 298 mAh g(-1) (after 10 cycles, 50 mA g(-1)), with ∼150 mAh g(-1) of charge accumulating between 0.1 and 0.001 V with negligible voltage hysteresis in that region, nearly 100% cycling Coulombic efficiency, and superb cycling retention and high rate capacity (255 mAh g(-1) at the 210th cycle, stable capacity of 203 mAh g(-1) at 500 mA g(-1)).

  4. Python Winding Itself Around Datacubes: How to Access Massive Multi-Dimensional Arrays in a Pythonic Way

    NASA Astrophysics Data System (ADS)

    Merticariu, Vlad; Misev, Dimitar; Baumann, Peter

    2017-04-01

    While python has developed into the lingua franca in Data Science there is often a paradigm break when accessing specialized tools. In particular for one of the core data categories in science and engineering, massive multi-dimensional arrays, out-of-memory solutions typically employ their own, different models. We discuss this situation on the example of the scalable open-source array engine, rasdaman ("raster data manager") which offers access to and processing of Petascale multi-dimensional arrays through an SQL-style array query language, rasql. Such queries are executed in the server on a storage engine utilizing adaptive array partitioning and based on a processing engine implementing a "tile streaming" paradigm to allow processing of arrays massively larger than server RAM. The rasdaman QL has acted as blueprint for forthcoming ISO Array SQL and the Open Geospatial Consortium (OGC) geo analytics language, Web Coverage Processing Service, adopted in 2008. Not surprisingly, rasdaman is OGC and INSPIRE Reference Implementation for their "Big Earth Data" standards suite. Recently, rasdaman has been augmented with a python interface which allows to transparently interact with the database (credits go to Siddharth Shukla's Master Thesis at Jacobs University). Programmers do not need to know the rasdaman query language, as the operators are silently transformed, through lazy evaluation, into queries. Arrays delivered are likewise automatically transformed into their python representation. In the talk, the rasdaman concept will be illustrated with the help of large-scale real-life examples of operational satellite image and weather data services, and sample python code.

  5. Study of Plasma Flow Modes in Imploding Nested Arrays

    NASA Astrophysics Data System (ADS)

    Mitrofanov, K. N.; Aleksandrov, V. V.; Gritsuk, A. N.; Branitsky, A. V.; Frolov, I. N.; Grabovski, E. V.; Sasorov, P. V.; Ol'khovskaya, O. G.; Zaitsev, V. I.

    2018-02-01

    Results from experimental studies of implosion of nested wire and fiber arrays at currents of up to 4 MA at the Angara-5-1 facility are presented. Depending on the ratio between the radii of the inner and outer arrays, different modes of the plasma flow in the space between the inner and outer arrays were implemented: the sub-Alfvénic ( V r < V A ) and super-Alfvénic ( V r > V A ) modes and a mode with the formation of the transition shock wave (SW) region between the cascades. By varying the material of the outer array (tungsten wires or kapron fibers), it is shown that the plasma flow mode between the inner and outer arrays depends on the ratio between the plasma production rates ṁ in / ṁ out in the inner and outer arrays. The obtained experimental results are compared with the results of one-dimensional MHD simulation of the plasma flow between the arrays. Stable implosion of the inner array plasma was observed in experiments with combined nested arrays consisting of a fiber outer array and a tungsten inner array. The growth rates of magnetic Rayleigh-Taylor (MRT) instability in the inner array plasma at different numbers of fibers in the outer array and different ratios between the radii of the inner and outer arrays are compared. Suppression of MRT instability during the implosion of the inner array plasma results in the formation of a stable compact Z-pinch and generation of a soft X-ray pulse. A possible scenario of interaction between the plasmas of the inner and outer arrays is offered. The stability of the inner array plasma in the stage of final compression depends on the character of interaction of plasma jets from the outer array with the magnetic field of the inner array.

  6. Electrochemical properties of high-power supercapacitors using ordered NiO coated Si nanowire array electrodes

    NASA Astrophysics Data System (ADS)

    Lu, Fang; Qiu, Mengchun; Qi, Xiang; Yang, Liwen; Yin, Jinjie; Hao, Guolin; Feng, Xiang; Li, Jun; Zhong, Jianxin

    2011-08-01

    Highly ordered NiO coated Si nanowire arrays are fabricated as electrode materials for electrochemical supercapacitors (ES) via depositing Ni on electroless-etched Si nanowires and subsequently annealing. The electrochemical tests reveal that the constructed electrode has superior electrical conductibility and more active sites per unit area for chemical reaction processes, thereby possessing good cycle stability, high specific capacity, and low internal resistance. The specific capacity is up to 787.5 F g-1 at a discharge current of 2.5 mA and decreases slightly with 4.039% loss after 500 cycles, while the equivalent internal resistance is ˜3.067 Ω. Owing to its favorable electrochemical performance, this ordered hybrid array nanostructure is a promising electrode material in future commercial ES.

  7. Monolithically integrated distributed feedback laser array wavelength-selectable light sources for WDM-PON application

    NASA Astrophysics Data System (ADS)

    Chen, Xin; Zhao, Jianyi; Zhou, Ning; Huang, Xiaodong; Cao, Mingde; Wang, Lei; Liu, Wen

    2015-01-01

    The monolithic integration of 1.5-μm four channels phase shift distributed feedback lasers array (DFB-LD array) with 4×1 multi-mode interference (MMI) optical combiner is demonstrated. A home developed process mainly consists of butt-joint regrowth (BJR) and simultaneous thermal and ultraviolet nanoimprint lithography (STU-NIL) is implemented to fabricate gratings and integrated devices. The threshold currents of the lasers are less than 10 mA and the side mode suppression ratios (SMSR) are better than 40 dB for all channels. Quasi-continuous tuning is realized over 7.5 nm wavelength region with the 30 °C temperature variation. The results indicate that the integration device we proposed can be used in wavelength division multiplexing passive optical networks (WDM-PON).

  8. U-Th-Pb zircon ages of some Keweenawan Supergroup rocks from the south shore of Lake Superior

    USGS Publications Warehouse

    Zartman, R.E.; Nicholson, S.W.; Cannon, W.F.; Morey, G.B.

    1997-01-01

    New single-crystal zircon U-Th-Pb ages for plutonic and rhyolitic Keweenawan Supergroup rocks from the south shore of Lake Superior provide geochronological constraints on magmatic evolution associated with the 1.1 Ga Midcontinent rift. Analyses of a granophyric phase of the Mineral Lake intrusion and the Meilen granite, both parts of the Meilen Intrusive Complex, and a laterally extensive rhyolite from the top of the Kallander Creek Volcanics have weighted average 207Pb/206Pb ages of 1102.0 ?? 2.8 Ma (N = 2), 1100.9 ?? 1.4 Ma (N = 5), and 1098.8 ?? 1.9 Ma (N = 4), respectively. Analyses of a pyroclastic rhyolite flow at the top of the Porcupine Volcanics result in variable 207Pb/206Pb ages that range from 1080 to 1137 Ma. This rhyolite exhibits a continuum between morphologically complex and simpler prismatic zircon crystals, the latter yielding concordant analyses having a weighted average 207Pb/206Pb age of 1093.6 ?? 1.8 Ma (N = 2). Four prismatic zircons from an aphyric rhyolite of the Chengwatana Volcanics in the Ashland syncline form a linear array intersecting concordia at 1094.6 ?? 2.1 Ma (MSWD = 1.3). Another presumed Chengwatana rhyolite recovered from drill core intersecting the Hudson-Afton horst in southeast Minnesota yielded only ???20 morphologically indistinguishable zircons. Six analyses give 207Pb/206Pb ages ranging from 1112 to 1136 Ma, including one analysis with a virtually concordant age of 1130 Ma. This age, however, is considerably older than that obtained for the Chengwatana Volcanics in the Ashland syncline or any other precisely dated rock from the Midcontinent rift.

  9. Sub-1-V-60 nm vertical body channel MOSFET-based six-transistor static random access memory array with wide noise margin and excellent power delay product and its optimization with the cell ratio on static random access memory cell

    NASA Astrophysics Data System (ADS)

    Ogasawara, Ryosuke; Endoh, Tetsuo

    2018-04-01

    In this study, with the aim to achieve a wide noise margin and an excellent power delay product (PDP), a vertical body channel (BC)-MOSFET-based six-transistor (6T) static random access memory (SRAM) array is evaluated by changing the number of pillars in each part of a SRAM cell, that is, by changing the cell ratio in the SRAM cell. This 60 nm vertical BC-MOSFET-based 6T SRAM array realizes 0.84 V operation under the best PDP and up to 31% improvement of PDP compared with the 6T SRAM array based on a 90 nm planar MOSFET whose gate length and channel width are the same as those of the 60 nm vertical BC-MOSFET. Additionally, the vertical BC-MOSFET-based 6T SRAM array achieves an 8.8% wider read static noise margin (RSNM), a 16% wider write margin (WM), and an 89% smaller leakage. Moreover, it is shown that changing the cell ratio brings larger improvements of RSNM, WM, and write time in the vertical BC-MOSFET-based 6T SRAM array.

  10. Preliminary experimental results of tungsten wire-array Z-pinches on primary test stand

    NASA Astrophysics Data System (ADS)

    Huang, Xian-Bin; Zhou, Shao-Tong; Dan, Jia-Kun; Ren, Xiao-Dong; Wang, Kun-Lun; Zhang, Si-Qun; Li, Jing; Xu, Qiang; Cai, Hong-Chun; Duan, Shu-Chao; Ouyang, Kai; Chen, Guang-Hua; Ji, Ce; Wei, Bing; Feng, Shu-Ping; Wang, Meng; Xie, Wei-Ping; Deng, Jian-Jun; Zhou, Xiu-Wen; Yang, Yi

    2015-07-01

    The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a 20 TW pulsed power driver, which can deliver a ˜10 MA, 70 ns rise-time (10%-90%) current to a short-circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. Preliminary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 13 mm to 30 mm, consisting of 132-300 tungsten wires with 5-10 μm in diameter. Multiple diagnostics were fielded to characterize the x-ray radiation from wire-array Z pinches. The x-ray peak power (˜50 TW) and total radiated energy (˜500 kJ) were obtained from a single 20-mm-diam array with 80-ns stagnation time. The highest x-ray peak power up to 80 TW with 2.4 ns FWHM was achieved by using a nested array with 20-mm outer diameter, and the total x-ray energy from the nested array is comparable to that of single array. Implosion velocity estimated from the time-resolved image measurement exceeds 30 cm/μs. The detailed experimental results and other findings are presented and discussed.

  11. Medicare Advantage and Fee-for-Service Performance on Clinical Quality and Patient Experience Measures: Comparisons from Three Large States.

    PubMed

    Timbie, Justin W; Bogart, Andy; Damberg, Cheryl L; Elliott, Marc N; Haas, Ann; Gaillot, Sarah J; Goldstein, Elizabeth H; Paddock, Susan M

    2017-12-01

    To compare performance between Medicare Advantage (MA) and Fee-for-Service (FFS) Medicare during a time of policy changes affecting both programs. Performance data for 16 clinical quality measures and 6 patient experience measures for 9.9 million beneficiaries living in California, New York, and Florida. We compared MA and FFS performance overall, by plan type, and within service areas associated with contracts between CMS and MA organizations. Case mix-adjusted analyses (for measures not typically adjusted) were used to explore the effect of case mix on MA/FFS differences. Performance measures were submitted by MA organizations, obtained from the nationwide fielding of the Medicare Consumer Assessment of Healthcare Providers and Systems (MCAHPS) Survey, or derived from claims. Overall, MA outperformed FFS on all 16 clinical quality measures. Differences were large for HEDIS measures and small for Part D measures and remained after case mix adjustment. MA enrollees reported better experiences overall, but FFS beneficiaries reported better access to care. Relative to FFS, performance gaps were much wider for HMOs than PPOs. Excluding HEDIS measures, MA/FFS differences were much smaller in contract-level comparisons. Medicare Advantage/Fee-for-Service differences are often large but vary in important ways across types of measures and contracts. © Health Research and Educational Trust.

  12. Cobalt-Doped Black TiO2 Nanotube Array as a Stable Anode for Oxygen Evolution and Electrochemical Wastewater Treatment.

    PubMed

    Yang, Yang; Kao, Li Cheng; Liu, Yuanyue; Sun, Ke; Yu, Hongtao; Guo, Jinghua; Liou, Sofia Ya Hsuan; Hoffmann, Michael R

    2018-05-04

    TiO 2 has long been recognized as a stable and reusable photocatalyst for water splitting and pollution control. However, it is an inefficient anode material in the absence of photoactivation due to its low electron conductivity. To overcome this limitation, a series of conductive TiO 2 nanotube array electrodes have been developed. Even though nanotube arrays are effective for electrochemical oxidation initially, deactivation is often observed within a few hours. To overcome the problem of deactivation, we have synthesized cobalt-doped Black-TiO 2 nanotube array (Co-Black NTA) electrodes that are stable for more than 200 h of continuous operation in a NaClO 4 electrolyte at 10 mA cm -2 . Using X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, electron paramagnetic resonance spectroscopy, and DFT simulations, we are able to show that bulk oxygen vacancies (O v ) are the primary source of the enhanced conductivity of Co-Black. Cobalt doping both creates and stabilizes surficial oxygen vacancies, O v , and thus prevents surface passivation. The Co-Black electrodes outperform dimensionally stable IrO 2 anodes (DSA) in the electrolytic oxidation of organic-rich wastewater. Increasing the loading of Co leads to the formation of a CoO x film on top of Co-Black electrode. The CoO x /Co-Black composite electrode was found to have a lower OER overpotential (352 mV) in comparison to a DSA IrO 2 (434 mV) electrode and a stability that is greater than 200 h in a 1.0 M KOH electrolyte at a current density of 10 mA cm -2 .

  13. Three-Dimensional Array of TiN@Pt3Cu Nanowires as an Efficient Porous Electrode for the Lithium-Oxygen Battery.

    PubMed

    Luo, Wen-Bin; Pham, Thien Viet; Guo, Hai-Peng; Liu, Hua-Kun; Dou, Shi-Xue

    2017-02-28

    The nonaqueous lithium-oxygen battery is a promising candidate as a next-generation energy storage system because of its potentially high energy density (up to 2-3 kW kg -1 ), exceeding that of any other existing energy storage system for storing sustainable and clean energy to reduce greenhouse gas emissions and the consumption of nonrenewable fossil fuels. To achieve high round-trip efficiency and satisfactory cycling stability, the air electrode structure and the electrocatalysts play important roles. Here, a 3D array composed of one-dimensional TiN@Pt 3 Cu nanowires was synthesized and employed as a whole porous air electrode in a lithium-oxygen battery. The TiN nanowire was primarily used as an air electrode frame and catalyst support to provide a high electronic conductivity network because of the high-orientation one-dimensional crystalline structure. Meanwhile, deposited icosahedral Pt 3 Cu nanocrystals exhibit highly efficient catalytic activity owing to the abundant {111} active lattice facets and multiple twin boundaries. This porous air electrode comprises a one-dimensional TiN@Pt 3 Cu nanowire array that demonstrates excellent energy conversion efficiency and rate performance in full discharge and charge modes. The discharge capacity is up to 4600 mAh g -1 along with an 84% conversion efficiency at a current density of 0.2 mA cm -2 , and when the current density increased to 0.8 mA cm -2 , the discharge capacity is still greater than 3500 mAh g -1 together with a nearly 70% efficiency. This designed array is a promising bifunctional porous air electrode for lithium-oxygen batteries, forming a continuous conductive and high catalytic activity network to facilitate rapid gas and electrolyte diffusion and catalytic reaction throughout the whole energy conversion process.

  14. Cobalt-Doped Black TiO2 Nanotube Array as a Stable Anode for Oxygen Evolution and Electrochemical Wastewater Treatment

    PubMed Central

    2018-01-01

    TiO2 has long been recognized as a stable and reusable photocatalyst for water splitting and pollution control. However, it is an inefficient anode material in the absence of photoactivation due to its low electron conductivity. To overcome this limitation, a series of conductive TiO2 nanotube array electrodes have been developed. Even though nanotube arrays are effective for electrochemical oxidation initially, deactivation is often observed within a few hours. To overcome the problem of deactivation, we have synthesized cobalt-doped Black-TiO2 nanotube array (Co-Black NTA) electrodes that are stable for more than 200 h of continuous operation in a NaClO4 electrolyte at 10 mA cm–2. Using X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, electron paramagnetic resonance spectroscopy, and DFT simulations, we are able to show that bulk oxygen vacancies (Ov) are the primary source of the enhanced conductivity of Co-Black. Cobalt doping both creates and stabilizes surficial oxygen vacancies, Ov, and thus prevents surface passivation. The Co-Black electrodes outperform dimensionally stable IrO2 anodes (DSA) in the electrolytic oxidation of organic-rich wastewater. Increasing the loading of Co leads to the formation of a CoOx film on top of Co-Black electrode. The CoOx/Co-Black composite electrode was found to have a lower OER overpotential (352 mV) in comparison to a DSA IrO2 (434 mV) electrode and a stability that is greater than 200 h in a 1.0 M KOH electrolyte at a current density of 10 mA cm–2. PMID:29755829

  15. Mapping the Spread of Methamphetamine Abuse in California From 1995 to 2008

    PubMed Central

    Ponicki, William R.; Remer, Lillian G.; Waller, Lance A.; Zhu, Li; Gorman, Dennis M.

    2013-01-01

    Objectives. From 1983 to 2008, the incidence of methamphetamine abuse and dependence (MA) presenting at hospitals in California increased 13-fold. We assessed whether this growth could be characterized as a drug epidemic. Methods. We geocoded MA discharges to residential zip codes from 1995 through 2008. We related discharges to population and environmental characteristics using Bayesian Poisson conditional autoregressive models, correcting for small area effects and spatial misalignment and enabling an assessment of contagion between areas. Results. MA incidence increased exponentially in 3 phases interrupted by implementation of laws limiting access to methamphetamine precursors. MA growth from 1999 through 2008 was 17% per year. MA was greatest in areas with larger White or Hispanic low-income populations, small household sizes, and good connections to highway systems. Spatial misalignment was a source of bias in estimated effects. Spatial autocorrelation was substantial, accounting for approximately 80% of error variance in the model. Conclusions. From 1995 through 2008, MA exhibited signs of growth and spatial spread characteristic of drug epidemics, spreading most rapidly through low-income White and Hispanic populations living outside dense urban areas. PMID:23078474

  16. High rate tests of the photon detection system for the LHCb RICH Upgrade

    NASA Astrophysics Data System (ADS)

    Blago, M. P.; Keizer, F.

    2017-12-01

    The photon detection system for the LHCb RICH Upgrade consists of an array of multianode photomultiplier tubes (MaPMTs) read out by custom-built modular electronics. The behaviour of the whole chain was studied at CERN using a pulsed laser. Threshold scans were performed in order to study the MaPMT pulse-height spectra at high event rates and different photon intensities. The results show a reduction in photon detection efficiency at 900 V bias voltage, marked by a 20% decrease in the single-photon peak height, when increasing the event rate from 100 kHz to 20 MHz. This reduction was not observed at 1000 V bias voltage.

  17. BACTERIOPHAGE PRD1 AND SILICA COLLOID TRANSPORT AND RECOVERY IN AN IRON OXIDE-COATED SAND AQUIFER. (R826179)

    EPA Science Inventory

    Bacteriophage PRD1 and silica colloids were co-injected into
    sewage-contaminated and uncontaminated zones of an iron oxide-coated sand
    aquifer on Cape Cod, MA, and their transport was monitored over distances up to
    6 m in three arrays. After deposition, the attache...

  18. 54. Photocopy of Structural drawing, dated August 6, 1976 by ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. Photocopy of Structural drawing, dated August 6, 1976 by Raytheon Company. Original drawing property of United States Air Force, 21" Space Command. S-14 - PAVE PAWS TECHNICAL FACILITY - OTIS AFB - ARRAY DETAILS. DRAWING NO. AW35-46-06 - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  19. Fetal Phthalate Screen: Assessment of Several Phthalate Esters (PE) on Fetal Rodent Testosterone (T) Production and Gene Expressionfollowing In Utero Exposure

    EPA Science Inventory

    PE are a large family of compounds used in a wide array of products from medical tubing to pharmaceuticals to cables. Studies have shown that in utero treatment with PE such as diethyl hexyl phthalate (DEHP) during the critical period of fetal reproductive development produced ma...

  20. 46. CAPE COD AIR STATION PAVE PAWS FACILITY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. CAPE COD AIR STATION PAVE PAWS FACILITY - BUILDING ELEVATION VIEW WITH ALL METAL SIDING INSTALLED AND WITH EMITTER/ANTENNA ARRAY SYSTEM NEARING OCMPLETION ON "B" FACE (RIGHT). VIEW ALSO SHOWS TRAVELING "CLEANING" SYSTEM ON "B" FACE - NOW REMOVED. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  1. MACULAR ATROPHY FINDINGS BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARED WITH FUNDUS AUTOFLUORESCENCE IN TREATED EXUDATIVE AGE-RELATED MACULAR DEGENERATION.

    PubMed

    Takasago, Yukari; Shiragami, Chieko; Kobayashi, Mamoru; Osaka, Rie; Ono, Aoi; Yamashita, Ayana; Tsujikawa, Akitaka; Hirooka, Kazuyuki

    2017-11-28

    To compare the areas of choriocapillaris (CC) nonperfusion and macular atrophy (MA) in treated exudative age-related macular degeneration. This was a prospective, observational, cross-sectional study. Forty-four eyes exhibiting MA (42 patients with age-related macular degeneration), with a dry macula, underwent fundus autofluorescence and optical coherence tomography angiography. The area of MA detected by fundus autofluorescence and CC nonperfusion detected by optical coherence tomography angiography was measured using image analysis software. The rates of concordance between the MA and CC nonperfusion areas were calculated. We qualitatively and quantitatively compared the areas of MA and CC nonperfusion in age-related macular degeneration eyes. The mean areas of MA and CC nonperfusion were 5.95 ± 4.50 mm and 10.66 ± 7.05 mm, respectively (paired t-test, P < 0.001). In 39 eyes (88.6%), the CC nonperfusion area was larger than the MA area, and the mean CC nonperfusion area was significantly larger than the mean MA area. Fundus autofluorescence matching optical coherence tomography angiography showed that the CC nonperfusion area was almost included in the MA area. The mean concordance rate for the MA area inside the CC nonperfusion area was 87.7 ± 13.9%. The MA and CC nonperfusion areas markedly overlapped. The area of CC nonperfusion correlated with the MA area. Choroidal ischemia might be involved in the pathogenesis of MA in treated age-related macular degeneration.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  2. The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study

    PubMed Central

    Ray, Lara A; Bujarski, Spencer; Courtney, Kelly E; Moallem, Nathasha R; Lunny, Katy; Roche, Daniel; Leventhal, Adam M; Shoptaw, Steve; Heinzerling, Keith; London, Edythe D; Miotto, Karen

    2015-01-01

    Methamphetamine (MA) use disorder is a serious psychiatric condition for which there are no FDA-approved medications. Naltrexone (NTX) is an opioid receptor antagonist with demonstrated efficacy, albeit moderate, for the treatment of alcoholism and opioid dependence. Preclinical and clinical studies suggest that NTX may be useful for the treatment of MA use disorder. To inform treatment development, we conducted a double-blind, randomized, crossover, placebo-controlled human laboratory study of NTX. Non-treatment-seeking individuals meeting DSM-IV criteria for MA abuse or dependence (n=30) completed two separate 5-day inpatient stays. During each admission, participants completed testing sessions comprised of MA cue-reactivity and intravenous MA administration (30 mg) after receiving oral NTX (50 mg) or placebo for 4 days. This study tested the hypotheses that NTX would (a) attenuate cue-induced MA craving, and (b) reduce subjective responses to MA administration. Results largely supported the study hypotheses such that (a) NTX significantly blunted cue-induced craving for MA and (b) attenuated several of the hedonic subjective effects of MA, including craving, during controlled MA administration and as compared with placebo. NTX decreased overall subjective ratings of ‘crave drug,' ‘stimulated,' and ‘would like drug access,' decreased the the post-MA administration timecourse of ‘anxious' and increased ratings of ‘bad drug effects,' as compared with placebo. These findings support a potential mechanism of action by showing that NTX reduced cue-induced craving and subjective responses to MA. This is consistent with positive treatment studies of NTX for amphetamine dependence, as well as ongoing clinical trials for MA. PMID:25801501

  3. Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking.

    PubMed

    Fultz, Elissa K; Martin, Douglas L; Hudson, Courtney N; Kippin, Tod E; Szumlinski, Karen K

    2017-08-01

    A high degree of co-morbidity exists between methamphetamine (MA) addiction and alcohol use disorders and both sequential and simultaneous MA-alcohol mixing increases risk for co-abuse. As little preclinical work has focused on the biobehavioral interactions between MA and alcohol within the context of drug-taking behavior, we employed simple murine models of voluntary oral drug consumption to examine how prior histories of either MA- or alcohol-taking influence the intake of the other drug. In one study, mice with a 10-day history of binge alcohol-drinking [5,10, 20 and 40% (v/v); 2h/day] were trained to self-administer oral MA in an operant-conditioning paradigm (10-40mg/L). In a second study, mice with a 10-day history of limited-access oral MA-drinking (5, 10, 20 and 40mg/L; 2h/day) were presented with alcohol (5-40% v/v; 2h/day) and then a choice between solutions of 20% alcohol, 10mg/L MA or their mix. Under operant-conditioning procedures, alcohol-drinking mice exhibited less MA reinforcement overall, than water controls. However, when drug availability was not behaviorally-contingent, alcohol-drinking mice consumed more MA and exhibited greater preference for the 10mg/L MA solution than drug-naïve and combination drug-experienced mice. Conversely, prior MA-drinking history increased alcohol intake across a range of alcohol concentrations. These exploratory studies indicate the feasibility of employing procedurally simple murine models of sequential and simultaneous oral MA-alcohol mixing of relevance to advancing our biobehavioral understanding of MA-alcohol co-abuse. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. SNPchiMp v.3: integrating and standardizing single nucleotide polymorphism data for livestock species.

    PubMed

    Nicolazzi, Ezequiel L; Caprera, Andrea; Nazzicari, Nelson; Cozzi, Paolo; Strozzi, Francesco; Lawley, Cindy; Pirani, Ali; Soans, Chandrasen; Brew, Fiona; Jorjani, Hossein; Evans, Gary; Simpson, Barry; Tosser-Klopp, Gwenola; Brauning, Rudiger; Williams, John L; Stella, Alessandra

    2015-04-10

    In recent years, the use of genomic information in livestock species for genetic improvement, association studies and many other fields has become routine. In order to accommodate different market requirements in terms of genotyping cost, manufacturers of single nucleotide polymorphism (SNP) arrays, private companies and international consortia have developed a large number of arrays with different content and different SNP density. The number of currently available SNP arrays differs among species: ranging from one for goats to more than ten for cattle, and the number of arrays available is increasing rapidly. However, there is limited or no effort to standardize and integrate array- specific (e.g. SNP IDs, allele coding) and species-specific (i.e. past and current assemblies) SNP information. Here we present SNPchiMp v.3, a solution to these issues for the six major livestock species (cow, pig, horse, sheep, goat and chicken). Original data was collected directly from SNP array producers and specific international genome consortia, and stored in a MySQL database. The database was then linked to an open-access web tool and to public databases. SNPchiMp v.3 ensures fast access to the database (retrieving within/across SNP array data) and the possibility of annotating SNP array data in a user-friendly fashion. This platform allows easy integration and standardization, and it is aimed at both industry and research. It also enables users to easily link the information available from the array producer with data in public databases, without the need of additional bioinformatics tools or pipelines. In recognition of the open-access use of Ensembl resources, SNPchiMp v.3 was officially credited as an Ensembl E!mpowered tool. Availability at http://bioinformatics.tecnoparco.org/SNPchimp.

  5. arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays

    PubMed Central

    Menten, Björn; Pattyn, Filip; De Preter, Katleen; Robbrecht, Piet; Michels, Evi; Buysse, Karen; Mortier, Geert; De Paepe, Anne; van Vooren, Steven; Vermeesch, Joris; Moreau, Yves; De Moor, Bart; Vermeulen, Stefan; Speleman, Frank; Vandesompele, Jo

    2005-01-01

    Background The availability of the human genome sequence as well as the large number of physically accessible oligonucleotides, cDNA, and BAC clones across the entire genome has triggered and accelerated the use of several platforms for analysis of DNA copy number changes, amongst others microarray comparative genomic hybridization (arrayCGH). One of the challenges inherent to this new technology is the management and analysis of large numbers of data points generated in each individual experiment. Results We have developed arrayCGHbase, a comprehensive analysis platform for arrayCGH experiments consisting of a MIAME (Minimal Information About a Microarray Experiment) supportive database using MySQL underlying a data mining web tool, to store, analyze, interpret, compare, and visualize arrayCGH results in a uniform and user-friendly format. Following its flexible design, arrayCGHbase is compatible with all existing and forthcoming arrayCGH platforms. Data can be exported in a multitude of formats, including BED files to map copy number information on the genome using the Ensembl or UCSC genome browser. Conclusion ArrayCGHbase is a web based and platform independent arrayCGH data analysis tool, that allows users to access the analysis suite through the internet or a local intranet after installation on a private server. ArrayCGHbase is available at . PMID:15910681

  6. Multiple-access phased array antenna simulator for a digital beam-forming system investigation

    NASA Technical Reports Server (NTRS)

    Kerczewski, Robert J.; Yu, John; Walton, Joanne C.; Perl, Thomas D.; Andro, Monty; Alexovich, Robert E.

    1992-01-01

    Future versions of data relay satellite systems are currently being planned by NASA. Being given consideration for implementation are on-board digital beamforming techniques which will allow multiple users to simultaneously access a single S-band phased array antenna system. To investigate the potential performance of such a system, a laboratory simulator has been developed at NASA's Lewis Research Center. This paper describes the system simulator, and in particular, the requirements, design and performance of a key subsystem, the phased array antenna simulator, which provides realistic inputs to the digital processor including multiple signals, noise, and nonlinearities.

  7. Multiple-access phased array antenna simulator for a digital beam forming system investigation

    NASA Technical Reports Server (NTRS)

    Kerczewski, Robert J.; Yu, John; Walton, Joanne C.; Perl, Thomas D.; Andro, Monty; Alexovich, Robert E.

    1992-01-01

    Future versions of data relay satellite systems are currently being planned by NASA. Being given consideration for implementation are on-board digital beamforming techniques which will allow multiple users to simultaneously access a single S-band phased array antenna system. To investigate the potential performance of such a system, a laboratory simulator has been developed at NASA's Lewis Research Center. This paper describes the system simulator, and in particular, the requirements, design, and performance of a key subsystem, the phased array antenna simulator, which provides realistic inputs to the digital processor including multiple signals, noise, and nonlinearities.

  8. Characterization of Sugar Concentration Among Edible Podded Accessions in the USDA Phaseolus vulgaris Germplasm Collection

    USDA-ARS?s Scientific Manuscript database

    The objective is to gain knowledge regarding variation in sugar and flavor content among a sample of dry bean and green pod-type accessions from the USDA Phaseolus Germplasm Core Collection, Pullman, WA. The results could be used to market product quality and offer unique opportunities to expand ma...

  9. Opportunistic Access in Frequency Hopping Cognitive Radio Networks

    DTIC Science & Technology

    2014-03-27

    thresholding MA multiple access MFSK M-ary frequency shift keying MIMO multiple-input/multiple-output OFDM orthogonal frequency-division multiplexing x...adaptive BER performance as a function of ISR with orthogonal frequency-division multiplexing ( OFDM ) interference present. . . . . . . . . . 41 4.15 Non...adaptive BER performance as a function of EB/N0 with OFDM interfer- ence present

  10. A Historical Analysis of Library Access for Death Row Inmates in Ohio.

    ERIC Educational Resources Information Center

    Ostrolenk, Lisa

    A historical study was conducted to determine what type of access to the prison legal library is received by prisoners now housed on death row at the Mansfield Correctional Institution (MaCI) (Mansfield, Ohio) that were formerly housed at the Southern Ohio Correctional Facility (SOCF) (Lucasville, Ohio). A satellite law library had been created…

  11. Coronal plasma development in wire-array z-pinches made of twisted-pairs

    NASA Astrophysics Data System (ADS)

    Hoyt, C. L.; Greenly, J. B.; Gourdain, P. A.; Knapp, P. F.; Pikuz, S. A.; Shelkovenko, T. A.; Hammer, D. A.; Kusse, B. R.

    2009-11-01

    We have investigated coronal and core plasma development in wire array z-pinches in which single fine wires are replaced by twisted-pairs (``cable'') on the 1 MA, 100 ns rise time COBRA pulsed power generator. X-ray radiography, employed to investigate dense wire core expansion, showed periodic axial nonuniformity and evidence for shock waves developing where the individual wire plasmas collide. Laser shadowgraphy images indicated that the axial instability properties of the coronal plasma are substantially modified from ordinary wire arrays. Cable mass per unit length, material and the twist wavelength were varied in order to study their effects upon the instability wavelength. Implosion uniformity and bright-spot formation, as well as magnetic topology evolution, have also been investigated using self-emission imaging, x-ray diagnostics and small B-dot probes, respectively. Results from the cable-array z-pinches will be compared with results from ordinary wire-array z-pinches. This research was supported by the SSAA program of the National Nuclear Security Administration under DOE Cooperative agreement DE-FC03-02NA00057.

  12. Accessing sparse arrays in parallel memories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Banerjee, U.; Gajski, D.; Kuck, D.

    The concept of dense and sparse execution of arrays is introduced. Arrays themselves can be stored in a dense or sparse manner in a parallel memory with m memory modules. The paper proposes hardware for speeding up the execution of array operations of the form c(c/sub 0/+ci)=a(a/sub 0/+ai) op b(b/sub 0/+bi), where a/sub 0/, a, b/sub 0/, b, c/sub 0/, c are integer constants and i is an index variable. The hardware handles 'sparse execution', in which the operation op is not executed for every value of i. The hardware also makes provision for 'sparse storage', in which memory spacemore » is not provided for every array element. It is shown how to access array elements of the above form without conflict in an efficient way. The efficiency is obtained by using some specialised units which are basically smart memories with priority detection, one's counting or associative searching. Generalisation to multidimensional arrays is shown possible under restrictions defined in the paper. 12 references.« less

  13. Smart Construction of Integrated CNTs/Li4Ti5O12 Core/Shell Arrays with Superior High‐Rate Performance for Application in Lithium‐Ion Batteries

    PubMed Central

    Yao, Zhujun; Zhou, Cheng‐ao; Zhong, Yu; Wang, Yadong; Deng, Shengjue; Wang, Weiqi; Wang, Xiuli

    2018-01-01

    Abstract Exploring advanced high‐rate anodes is of great importance for the development of next‐generation high‐power lithium‐ion batteries (LIBs). Here, novel carbon nanotubes (CNTs)/Li4Ti5O12 (LTO) core/shell arrays on carbon cloth (CC) as integrated high‐quality anode are constructed via a facile combined chemical vapor deposition–atomic layer deposition (ALD) method. ALD‐synthesized LTO is strongly anchored on the CNTs' skeleton forming core/shell structures with diameters of 70–80 nm the combined advantages including highly conductive network, large surface area, and strong adhesion are obtained in the CC‐LTO@CNTs core/shell arrays. The electrochemical performance of the CC‐CNTs/LTO electrode is completely studied as the anode of LIBs and it shows noticeable high‐rate capability (a capacity of 169 mA h g−1 at 1 C and 112 mA h g−1 at 20 C), as well as a stable cycle life with a capacity retention of 86% after 5000 cycles at 10 C, which is much better than the CC‐LTO counterpart. Meanwhile, excellent cycling stability is also demonstrated for the full cell with LiFePO4 cathode and CC‐CNTs/LTO anode (87% capacity retention after 1500 cycles at 10 C). These positive features suggest their promising application in high‐power energy storage areas. PMID:29593977

  14. The relationship between gold ore and geotectonic in West Qinling: Evidence from magnetotelluric soundings

    NASA Astrophysics Data System (ADS)

    Xu, Daili; Huang, Wei; Zhang, Letian

    2017-03-01

    The West Qinling belt is the westward extensioin of the Qinling-Dabie-Sulu orogen in central China. It links the Kunlun and Qilian orogens to the west and the Songpan-Ganze belt to the south, making it an important tectonics syntaxis in China. According to the collection and analysis of the data of West Qinling Mountains gold deposit metallogenic chronology, the gold deposits in this area can be divided into five groups by time: 225-245 Ma, 220-190 Ma, 170 Ma±, 135-110 Ma, 75-45 Ma. The formation time is related to the geological process at that time. The relationship between the formation of gold deposit and geological structure can be explored by the research on the present geological structures. According to the regional tectonic evolution and magmatic activity, the gold deposits are divided into four metallogenic epoches: from the end of the Indo-Chinese epoch to the early Yanshanian (245-225 Ma), is one of the initial stages of gold mineralization; the early and the middle Yanshanian (220-190 Ma, 170 Ma±), is the main forming time of the gold mineralization in the West Qinling; the late Yanshanian (135-110 Ma), is the superimposed mineralization stage; at last, the effect of Himalayan hydrothermal activity to the gold deposits. Under the support of three projects naemed " the research on the conductivity of the lithosphere of the Central Orogenic in China ", " the MT array observation of the intersection area of COC(Central Orogen in China) and the North-South seismic belt ", " the experiment research of MT standard network observation in the area of Qinghai-Tibetan Plateau and the North-China " (Sinoprobe-01-02), we collected massive magnetotellurics data for futher study of the present geological strusctures to discess the relationship between gold deposites and geotectonic in West Qinling.

  15. Characterization of a Wheat Breeders' Array suitable for high-throughput SNP genotyping of global accessions of hexaploid bread wheat (Triticum aestivum).

    PubMed

    Allen, Alexandra M; Winfield, Mark O; Burridge, Amanda J; Downie, Rowena C; Benbow, Harriet R; Barker, Gary L A; Wilkinson, Paul A; Coghill, Jane; Waterfall, Christy; Davassi, Alessandro; Scopes, Geoff; Pirani, Ali; Webster, Teresa; Brew, Fiona; Bloor, Claire; Griffiths, Simon; Bentley, Alison R; Alda, Mark; Jack, Peter; Phillips, Andrew L; Edwards, Keith J

    2017-03-01

    Targeted selection and inbreeding have resulted in a lack of genetic diversity in elite hexaploid bread wheat accessions. Reduced diversity can be a limiting factor in the breeding of high yielding varieties and crucially can mean reduced resilience in the face of changing climate and resource pressures. Recent technological advances have enabled the development of molecular markers for use in the assessment and utilization of genetic diversity in hexaploid wheat. Starting with a large collection of 819 571 previously characterized wheat markers, here we describe the identification of 35 143 single nucleotide polymorphism-based markers, which are highly suited to the genotyping of elite hexaploid wheat accessions. To assess their suitability, the markers have been validated using a commercial high-density Affymetrix Axiom ® genotyping array (the Wheat Breeders' Array), in a high-throughput 384 microplate configuration, to characterize a diverse global collection of wheat accessions including landraces and elite lines derived from commercial breeding communities. We demonstrate that the Wheat Breeders' Array is also suitable for generating high-density genetic maps of previously uncharacterized populations and for characterizing novel genetic diversity produced by mutagenesis. To facilitate the use of the array by the wheat community, the markers, the associated sequence and the genotype information have been made available through the interactive web site 'CerealsDB'. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  16. Packaging and testing of multi-wavelength DFB laser array using REC technology

    NASA Astrophysics Data System (ADS)

    Ni, Yi; Kong, Xuan; Gu, Xiaofeng; Chen, Xiangfei; Zheng, Guanghui; Luan, Jia

    2014-02-01

    Packaging of distributed feedback (DFB) laser array based on reconstruction-equivalent-chirp (REC) technology is a bridge from chip to system, and influences the practical process of REC chip. In this paper, DFB laser arrays of 4-channel @1310 nm and 8-channel @1550 nm are packaged. Our experimental results show that both these laser arrays have uniform wavelength spacing and larger than 35 dB average Side Mode Suppression Ratio (SMSR). When I=35 mA, we obtain the total output power of 1 mW for 4-channel @1310 nm, and 227 μw for 8-channel @1550 nm respectively. The high frequency characteristics of the packaged chips are also obtained, and the requirements for 4×10 G or even 8×10 G systems can be reached. Our results demonstrate the practical and low cost performance of REC technology and indicate its potential in the future fiber-to-the-home (FTTH) application.

  17. Targeted synthesis of novel hierarchical sandwiched NiO/C arrays as high-efficiency lithium ion batteries anode

    NASA Astrophysics Data System (ADS)

    Feng, Yangyang; Zhang, Huijuan; Li, Wenxiang; Fang, Ling; Wang, Yu

    2016-01-01

    In this contribution, the novel 2D sandwich-like NiO/C arrays on Ti foil are successfully designed and fabricated for the first time via simple and controllable hydrothermal process. In this strategy, we use green glucose as carbon source and ultrathin Ni(OH)2 nanosheet arrays as precursor for NiO nanoparticles and sacrificial templates for coupled graphitized carbon layers. This advanced sandwiched composite can not only provide large surface area for numerous active sites and continuous contact between active materials and electrolyte, but also protect the active nanoparticles from aggregation, pulverization and peeling off from conductive substrates. Furthermore, the porous structure derived from lots of substances loss under high-temperature calcinations can effectively buffer possible volume expansion and facilitate ion transfer. In this article, sandwiched NiO/C arrays, utilized as anode for LIBs, demonstrated high specific capacity (∼1458 mAh g-1 at 500 mA g-1) and excellent rate performance and cyclablity (∼95.7% retention after 300 cycles).

  18. MIT Lincoln Laboratory Annual Report 2014

    DTIC Science & Technology

    2014-01-01

    NAME(S) AND ADDRESS(ES) Massachusetts Institute of Technology,Lincoln Laboratory,244 Wood Street,Lexington,MA,02420 8. PERFORMING ORGANIZATION...microseconds) transmon qubits. Juan Montoya, Andrew Benedick, and Scot Shaw use prototype technology to demonstrate a new optical phased array beam...really care about. In fact, the Woods Hole Oceanographic Institution, which is designing and building UUVs, is interested in the systems the

  19. Mastering the Online Master's: Developing and Delivering an Online MA in English Language Teaching through a Dialogic-Based Framework

    ERIC Educational Resources Information Center

    Baker, Will; Watson, Julie

    2014-01-01

    With an ever increasing array of technologies offering potential for the delivery of educational e-content and support of online communication and interaction, distance learning has an opportunity to make the transition to authentic online learning and teaching as never before. However, it seems that institutions are only slowly exploiting this…

  20. Hard X-ray and Particle Beams Research on 1.7 MA Z-pinch and Laser Plasma Experiments

    NASA Astrophysics Data System (ADS)

    Shrestha, Ishor; Kantsyrev, Victor; Safronova, Alla; Esaulov, Andrey; Nishio, Mineyuki; Shlyaptseva, Veronica; Keim, Steven; Weller, Michael; Stafford, Austin; Petkov, Emil; Schultz, Kimberly; Cooper, Matthew; PPDL Team

    2013-10-01

    Studies of hard x-ray (HXR) emission, electron and ion beam generation in z-pinch and laser plasmas are important for Inertial Confinement Fusion (ICF) and development of HXR sources from K-shell and L-shell radiation. The characteristics of HXR and particle beams produced by implosions of planar wire arrays, nested and single cylindrical wire arrays, and X-pinches were analyzed on 100 ns UNR Zebra generator with current up to 1.7 MA. In addition, the comparison of characteristics of HXR and electron beams on Zebra and 350 fs UNR Leopard laser experiments with foils has been performed. The diagnostics include Faraday cups, HXR diodes, different x-ray spectrometers and imaging systems, and ion mass spectrometer using the technique of Thomson parabola. Future work on HXRs and particle beams in HED plasmas is discussed. This work was supported by the DOE/NNSA Cooperative agreement DE-NA0001984 and in part by DE-FC52-06NA27616. This work was also supported by the Defense Threat Reduction Agency, Basic Research Award # HDTRA1-13-1-0033, to University of Nevada, Reno.

  1. Wire array K-shell sources on the SPHINX generator

    NASA Astrophysics Data System (ADS)

    D'Almeida, Thierry; Lassalle, Francis; Grunenwald, Julien; Maury, Patrick; Zucchini, Frédéric; Niasse, Nicolas; Chittenden, Jeremy

    2014-10-01

    The SPHINX machine is a LTD based Z-pinch driver operated by the CEA Gramat (France) and primarily used for studying K-shell radiation effects. We present the results of experiments carried out with single and nested large diameter aluminium wire array loads driven by a current of ~5 MA in ~800 ns. The dynamic of the implosion is studied with filtered X-UV time-integrated pin-hole cameras. The plasma electron temperature and the characteristics of the sources are estimated with time and spatially dependent spectrographs and PCDs. It is shown that Al K-shell yields (>1 keV) up to 27 kJ are obtained for a total radiation of ~ 230 kJ. These results are compared with simulations performed using the latest implementation of the non-LTE DCA code Spk in the 3D Eulerian MHD framework Gorgon developed at Imperial College. Filtered synthetic bolometers and PCD signals, time-dependent spatially integrated spectra and X-UV images are produced and show a good agreement with the experimental data. The capabilities of a prospective SPHINX II machine (20 MA ~ 800 ns) are also assessed for a wider variety of sources (Ti, Cu and W).

  2. U-Pb age of the Diana Complex and Adirondack granulite petrogenesis

    USGS Publications Warehouse

    Basu, A.R.; Premo, W.R.

    2001-01-01

    U-Pb isotopic analyses of eight single and multi-grain zircon fractions separated from a syenite of the Diana Complex of the Adirondack Mountains do not define a single linear array, but a scatter along a chord that intersects the Concordia curve at 1145 ?? 29 and 285 ?? 204 Ma. For the most concordant analyses, the 207Pb/206Pb ages range between 1115 and 1150 Ma. Detailed petrographic studies revealed that most grains contained at least two phases of zircon growth, either primary magmatic cores enclosed by variable thickness of metamorphic overgrowths or magmatic portions enclosing presumably older xenocrystic zircon cores. The magmatic portions are characterized by typical dipyramidal prismatic zoning and numerous black inclusions that make them quite distinct from adjacent overgrowths or cores when observed in polarizing light microscopy and in back-scattered electron micrographs. Careful handpicking and analysis of the "best" magmatic grains, devoid of visible overgrowth of core material, produced two nearly concordant points that along with two of the multi-grain analyses yielded an upper-intercept age of 1118 ?? 2.8 Ma and a lower-intercept age of 251 ?? 13 Ma. The older age is interpreted as the crystallization age of the syenite and the younger one is consistent with late stage uplift of the Appalachian region. The 1118 Ma age for the Diana Complex, some 35 Ma younger than previously believed, is now approximately synchronous with the main Adirondack anorthosite intrusion, implying a cogenetic relationship among the various meta-igneous rocks of the Adirondacks. The retention of a high-temperature contact metamorphic aureole around Diana convincingly places the timing of Adirondack regional metamorphism as early as 1118 Ma. This result also implies that the sources of anomalous high-temperature during granulite metamorphism are the syn-metamorphic intrusions, such as the Diana Complex.

  3. Manycast routing, modulation level and spectrum assignment over elastic optical networks

    NASA Astrophysics Data System (ADS)

    Luo, Xiao; Zhao, Yang; Chen, Xue; Wang, Lei; Zhang, Min; Zhang, Jie; Ji, Yuefeng; Wang, Huitao; Wang, Taili

    2017-07-01

    Manycast is a point to multi-point transmission framework that requires a subset of destination nodes successfully reached. It is particularly applicable for dealing with large amounts of data simultaneously in bandwidth-hungry, dynamic and cloud-based applications. As rapid increasing of traffics in these applications, the elastic optical networks (EONs) may be relied on to achieve high throughput manycast. In terms of finer spectrum granularity, the EONs could reach flexible accessing to network spectrum and efficient providing exact spectrum resource to demands. In this paper, we focus on the manycast routing, modulation level and spectrum assignment (MA-RMLSA) problem in EONs. Both EONs planning with static manycast traffic and EONs provisioning with dynamic manycast traffic are investigated. An integer linear programming (ILP) model is formulated to derive MA-RMLSA problem in static manycast scenario. Then corresponding heuristic algorithm called manycast routing, modulation level and spectrum assignment genetic algorithm (MA-RMLSA-GA) is proposed to adapt for both static and dynamic manycast scenarios. The MA-RMLSA-GA optimizes MA-RMLSA problem in destination nodes selection, routing light-tree constitution, modulation level allocation and spectrum resource assignment jointly, to achieve an effective improvement in network performance. Simulation results reveal that MA-RMLSA strategies offered by MA-RMLSA-GA have slightly disparity from the optimal solutions provided by ILP model in static scenario. Moreover, the results demonstrate that MA-RMLSA-GA realizes a highly efficient MA-RMLSA strategy with the lowest blocking probability in dynamic scenario compared with benchmark algorithms.

  4. Relationships between Medicare Advantage contract characteristics and quality-of-care ratings: an observational analysis of Medicare Advantage star ratings.

    PubMed

    Xu, Peng; Burgess, James F; Cabral, Howard; Soria-Saucedo, Rene; Kazis, Lewis E

    2015-03-03

    The Centers for Medicare & Medicaid Services (CMS) publishes star ratings on Medicare Advantage (MA) contracts to measure plan quality of care with implications for reimbursement and bonuses. To investigate whether MA contract characteristics are associated with quality of care through the Medicare plan star ratings. Retrospective study of MA star ratings in 2010. Unadjusted and adjusted multivariable linear regression models assessed the relationship between 5-star rating summary scores and plan characteristics. CMS MA contracts nationally. 409 (71%) of a total of 575 MA contracts, covering 10.56 million Medicare beneficiaries (90% of the MA population) in the United States in 2010. The MA quality ratings summary score (stars range from 1 to 5) is a quality measure based on 36 indicators related to processes of care, health outcomes, access to care, and beneficiary satisfaction. Nonprofit, larger, and older MA contracts were more likely to receive higher star ratings. Star ratings ranged from 2 to 5. Nonprofit contracts received an average 0.55 (95% CI, 0.42 to 0.67) higher star ratings than for-profit contracts (P  < 0.001) after controls were set for contract characteristics. The study focused on persons aged 65 years or older covered by MA. In 2010, nonprofit MA contracts received significantly higher star ratings than for-profit contracts. When comparing health plans in the future, the CMS should give increasing attention to for-profit plans with lower quality ratings and consider developing programs to assist newer and smaller plans in improving their care for Medicare beneficiaries. None.

  5. Mortality Differences Between Traditional Medicare and Medicare Advantage: A Risk-Adjusted Assessment Using Claims Data

    PubMed Central

    Beveridge, Roy A.; Mendes, Sean M.; Caplan, Arial; Rogstad, Teresa L.; Olson, Vanessa; Williams, Meredith C.; McRae, Jacquelyn M.; Vargas, Stefan

    2017-01-01

    Medicare Advantage (MA) has grown rapidly since the Affordable Care Act; nearly one-third of Medicare beneficiaries now choose MA. An assessment of the comparative value of the 2 options is confounded by an apparent selection bias favoring MA, as reflected in mortality differences. Previous assessments have been hampered by lack of access to claims diagnosis data for the MA population. An indirect comparison of mortality as an outcome variable was conducted by modeling mortality on a traditional fee-for-service (FFS) Medicare data set, applying the model to an MA data set, and then evaluating the ratio of actual-to-predicted mortality in the MA data set. The mortality model adjusted for clinical conditions and demographic factors. Model development considered the effect of potentially greater coding intensity in the MA population. Further analysis calculated ratios for subpopulations. Predicted, risk-adjusted mortality was lower in the MA population than in FFS Medicare. However, the ratio of actual-to-predicted mortality (0.80) suggested that the individuals in the MA data set were less likely to die than would be predicted had those individuals been enrolled in FFS Medicare. Differences between actual and predicted mortality were particularly pronounced in low income (dual eligibility), nonwhite race, high morbidity, and Health Maintenance Organization (HMO) subgroups. After controlling for baseline clinical risk as represented by claims diagnosis data, mortality differences favoring MA over FFS Medicare persisted, particularly in vulnerable subgroups and HMO plans. These findings suggest that differences in morbidity do not fully explain differences in mortality between the 2 programs. PMID:28578605

  6. Thermometers: Understand the Options

    MedlinePlus

    ... the options Thermometers come in a variety of styles. Understand the different types of thermometers and how ... MA. Fever in infants and children: Pathophysiology and management. http://www.uptodate.com/home. Accessed July 23, ...

  7. Design analysis tracking and data relay satellite simulation system

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The design and development of the equipment necessary to simulate the S-band multiple access link between user spacecraft, the Tracking and Data Relay Satellite, and a ground control terminal are discussed. The core of the S-band multiple access concept is the use of an Adaptive Ground Implemented Phased Array. The array contains thirty channels and provides the multiplexing and demultiplexing equipment required to demonstrate the ground implemented beam forming feature. The system provided will make it possible to demonstrate the performance of a desired user and ten interfering sources attempting to pass data through the multiple access system.

  8. Impact of improvement of water supply on household economy in a squatter area of Manila.

    PubMed

    Aiga, Hirotsugu; Umenai, Takusei

    2002-08-01

    To estimate the impact of the improvement of water supply. a comparative study on water collection and household expenditure on water was conducted between a former squatter community with an improved water supply (Leveriza: LE) and a typical squatter community with public water faucets (Maestranza: MA) in Manila, the Philippines. Data were collected from 201 structured household interviews and a focus group discussion among housewives in each community. To measure the time spent collecting water, observations of private and public water faucets were conducted. The residents in LE enjoyed significantly larger quantities of water from private water connections than in MA, where only three public water faucets were available as a water source. Conversely, the unit price of water in LE was much lower than in MA. In LE, 72.1% of the households started working for more income using time saved through the improvement of water supply and the proportion of the households under the poverty threshold was reduced from 55.6% to 29.9%. In MA, 68.6% of the households expressed their willingness to work for more income when time spent collecting water was saved. It would be possible for MA to reduce the proportion of the households under the poverty threshold through the improvement of the water supply. The results of the study indicated that the improvement of water supply would possibly encourage urban slum residents to increase their household incomes through reallocating time saved to income-generating activities. The underserved residents spent more money for less water compared to those with access to private water connections. In MA, it took 3-4 h, on average, to complete one water collecting task, even though the nearest public water faucet was within 100 m of any housing unit. This suggests that the definition of accessibility to safe water be reconsidered when discussing the urban poor.

  9. Morphometric approach to thermodynamic quantities of solvation of complex molecules: Extension to multicomponent solvent

    NASA Astrophysics Data System (ADS)

    Kodama, Ryota; Roth, Roland; Harano, Yuichi; Kinoshita, Masahiro

    2011-07-01

    The morphometric approach (MA) is a powerful tool for calculating a solvation free energy (SFE) and related quantities of solvation thermodynamics of complex molecules. Here, we extend it to a solvent consisting of m components. In the integral equation theories, the SFE is expressed as the sum of m terms each of which comprises solute-component j correlation functions (j = 1, …, m). The MA is applied to each term in a formally separate manner: The term is expressed as a linear combination of the four geometric measures, excluded volume, solvent-accessible surface area, and integrated mean and Gaussian curvatures of the accessible surface, which are calculated for component j. The total number of the geometric measures or the coefficients in the linear combinations is 4m. The coefficients are determined in simple geometries, i.e., for spherical solutes with various diameters in the same multicomponent solvent. The SFE of the spherical solutes are calculated using the radial-symmetric integral equation theory. The extended version of the MA is illustrated for a protein modeled as a set of fused hard spheres immersed in a binary mixture of hard spheres. Several mixtures of different molecular-diameter ratios and compositions and 30 structures of the protein with a variety of radii of gyration are considered for the illustration purpose. The SFE calculated by the MA is compared with that by the direct application of the three-dimensional integral equation theory (3D-IET) to the protein. The deviations of the MA values from the 3D-IET values are less than 1.5%. The computation time required is over four orders of magnitude shorter than that in the 3D-IET. The MA thus developed is expected to be best suited to analyses concerning the effects of cosolvents such as urea on the structural stability of a protein.

  10. Analysis of Antibacterial Activity and Bioactive Compounds of the Giant Mushroom, Macrocybe gigantea (Agaricomycetes), from India.

    PubMed

    Gaur, Tanvi; Rao, P B

    2017-01-01

    The antibacterial activity, phenolic profile, and bioactive compounds of fruiting bodies from 2 strains (MA1 and MA2) of the giant mushroom Macrocybe gigantea were evaluated to access their nutraceutical efficacy. The antibacterial activity was higher in MA2 against all selected pathogenic bacteria. Selected phenolics were analyzed by high-performance liquid chromatography coupled with ultraviolet-visible detection. Gallic acid, ferulic acid, quercetin, p-hydroxy benzoic acid, cinnamic acid, and rutin contents (micrograms per gram dry weight) were quantified. Quercetin and rutin were absent in both strains of M. gigantea. M. gigantea MA2 showed relatively higher phenolic content (915.8 μg/g dry weight) than M. gigantea MA1 (854.4 μg/g dry weight). Among the phenolics, gallic acid is found in the largest amount; in M. gigantea MA2, it was 847.9 ± 2.67 μg/g dry weight. Gas chromatography-mass spectrometry analysis showed the presence of bioactive compounds in both strains; most compounds were antibacterial. Thus, the selected strains of M. gigantea can combat oxidative damage and can be used in foods, pharmaceuticals, and cosmetics because of their antioxidant potential.

  11. Minimalist transcatheter aortic valve replacement: The new standard for surgeons and cardiologists using transfemoral access?

    PubMed

    Jensen, Hanna A; Condado, Jose F; Devireddy, Chandan; Binongo, Jose; Leshnower, Bradley G; Babaliaros, Vasilis; Sarin, Eric L; Lerakis, Stamatios; Guyton, Robert A; Stewart, James P; Syed, Amjadullah Q; Mavromatis, Kreton; Kaebnick, Brian; Rajaei, Mohammad Hossein; Tsai, Lillian L; Rahman, Ayaz; Simone, Amy; Keegan, Patricia; Block, Peter C; Thourani, Vinod H

    2015-10-01

    A minimalist approach for transcatheter aortic valve replacement (MA-TAVR) utilizing transfemoral access under conscious sedation and transthoracic echocardiography is increasing in popularity. This relatively novel technique may necessitate a learning period to achieve proficiency in performing a successful and safe procedure. This report evaluates our MA-TAVR cohort with specific characterization between our early, midterm, and recent experience. We retrospectively reviewed 151 consecutive patients who underwent MA-TAVR with surgeons and interventionists equally as primary operator at Emory University between May 2012 and July 2014. Our institution had performed 300 TAVR procedures before implementation of MA-TAVR. Patient characteristics and early outcomes were compared using Valve Academic Research Consortium 2 definitions among 3 groups: group 1 included the first 50 patients, group 2 included patients 51 to 100, and group 3 included patients 101 to 151. Median age for all patients was 84 years and similar among groups. The majority of patients were men (56%) and the median ejection fraction for all patients was 55% (interquartile range, 38.0%-60.0%). The majority of patients were high-risk surgical candidates with a median Society of Thoracic Surgeons Predicted Risk of Mortality of 10.0% and similar among groups. The overall major stroke rate was 3.3%, major vascular complications occurred in 3% of patients, and greater-than-mild paravalvular leak rate was 7%. In-hospital mortality and morbidity were similar among all 3 groups. In a high-volume TAVR center, transition to MA-TAVR is feasible with acceptable outcomes and a diminutive procedural learning curve. We advocate for TAVR centers to actively pursue the minimalist technique with equal representation by cardiologists and surgeons. Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

  12. Temporary authorization for use: does the French patient access programme for unlicensed medicines impact market access after formal licensing?

    PubMed

    Degrassat-Théas, Albane; Paubel, Pascal; Parent de Curzon, Olivier; Le Pen, Claude; Sinègre, Martine

    2013-04-01

    To reach the French market, a new drug requires a marketing authorization (MA) and price and reimbursement agreements. These hurdles could delay access to new and promising drugs. Since 1992, French law authorizes the use of unlicensed drugs on an exceptional and temporary basis through a compassionate-use programme, known as Temporary Authorization for Use (ATU). This programme was implemented to improve early access to drugs under development or authorized abroad. However, it is suspected to be inflationary, bypassing public bodies in charge of health technology assessment (HTA) and of pricing. The aim of this study is to observe the market access after the formal licensing of drugs that went through this compassionate-use programme. We included all ATUs that received an MA between 1 January 2005 and 30 June 2010. We first examined market access delays from these drugs using the standard administrative path. We positioned this result in relation to launch delays observed in France (for all outpatient drugs) and in other major European markets. Second, we assessed the bargaining power of a hospital purchaser after those drugs had obtained an MA by calculating the price growth rate after the approval. During the study period, 77 ATUs were formally licensed. The study concluded that, from the patient's perspective, licensing and public bodies' review time was shortened by a combined total of 36 months. The projected 11-month review time of public bodies may be longer than delays usually observed for outpatient drugs. Nonetheless, the study revealed significant benefits for French patient access based on comparable processing to launch time with those of other European countries with tight price control policies. In return, a 12 % premium, on average, is paid to pharmaceutical companies while drugs are under this status (sub-analysis on 56 drugs). In many instances, the ATU programme responds to a public health need by accelerating the availability of new drugs even though this study suggests an impact of the programme on the market access of these drugs for which the standard administrative path is longer than usual. In addition, pharmaceutical companies seem to market compassionate-use drugs with a presumed benefit/risk ratio at a price that guarantees a margin for future negotiation.

  13. 75 FR 37419 - Agency Information Collection Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    .... If you anticipate difficulty in submitting comments within that period or if you want access to the...: Written comments should be sent to the following: Denise Clarke, Procurement Analyst, MA-612/950 L'Enfant...

  14. Microbial Diagnostic Array Workstation (MDAW): a web server for diagnostic array data storage, sharing and analysis

    PubMed Central

    Scaria, Joy; Sreedharan, Aswathy; Chang, Yung-Fu

    2008-01-01

    Background Microarrays are becoming a very popular tool for microbial detection and diagnostics. Although these diagnostic arrays are much simpler when compared to the traditional transcriptome arrays, due to the high throughput nature of the arrays, the data analysis requirements still form a bottle neck for the widespread use of these diagnostic arrays. Hence we developed a new online data sharing and analysis environment customised for diagnostic arrays. Methods Microbial Diagnostic Array Workstation (MDAW) is a database driven application designed in MS Access and front end designed in ASP.NET. Conclusion MDAW is a new resource that is customised for the data analysis requirements for microbial diagnostic arrays. PMID:18811969

  15. Microbial Diagnostic Array Workstation (MDAW): a web server for diagnostic array data storage, sharing and analysis.

    PubMed

    Scaria, Joy; Sreedharan, Aswathy; Chang, Yung-Fu

    2008-09-23

    Microarrays are becoming a very popular tool for microbial detection and diagnostics. Although these diagnostic arrays are much simpler when compared to the traditional transcriptome arrays, due to the high throughput nature of the arrays, the data analysis requirements still form a bottle neck for the widespread use of these diagnostic arrays. Hence we developed a new online data sharing and analysis environment customised for diagnostic arrays. Microbial Diagnostic Array Workstation (MDAW) is a database driven application designed in MS Access and front end designed in ASP.NET. MDAW is a new resource that is customised for the data analysis requirements for microbial diagnostic arrays.

  16. An amorphous FeMoS4 nanorod array toward efficient hydrogen evolution electrocatalysis under neutral conditions.

    PubMed

    Ren, Xiang; Wang, Weiyi; Ge, Ruixiang; Hao, Shuai; Qu, Fengli; Du, Gu; Asiri, Abdullah M; Wei, Qin; Chen, Liang; Sun, Xuping

    2017-08-08

    It is highly attractive to develop efficient hydrogen-evolving electrocatalysts under neutral conditions. In this communication, we report an amorphous FeMoS 4 nanorod array on carbon cloth (FeMoS 4 NRA/CC) prepared by hydrothermal treatment of an FeOOH nanorod array on carbon cloth (FeOOH NRA/CC) in (NH 4 ) 2 MoS 4 solution. As a 3D electrode for hydrogen evolution electrocatalysis, this FeMoS 4 NRA/CC demonstrates superior catalytic activity and strong long-term electrochemical durability in 1.0 M phosphate buffered saline (pH: 7). It needs an overpotential of 204 mV to drive a geometrical current density of 10 mA cm -2 , which is 450 mV less than that for FeOOH NRA/CC. Density functional theory calculations suggest that FeMoS 4 has a more favourable hydrogen adsorption free energy than FeOOH.

  17. An integrated open-cavity system for magnetic bead manipulation.

    PubMed

    Abu-Nimeh, F T; Salem, F M

    2013-02-01

    Superparamagnetic beads are increasingly used in biomedical assays to manipulate, transport, and maneuver biomaterials. We present a low-cost integrated system designed in bulk CMOS to manipulate and separate biomedical magnetic beads. The system consists of 8 × 8 coil-arrays suitable for single bead manipulation, or collaborative multi-bead manipulation, using pseudo-parallel executions. We demonstrate the flexibility of the design in terms of different coil sizes, DC current levels, and layout techniques. In one array module example, the size of a single coil is 30 μm × 30 μm and the full array occupies an area of 248 μm × 248 μm in 0.5 μm CMOS technology. The programmable DC current source supports 8 discrete levels up to 1.5 mA. The total power consumption of the entire module is 9 mW when running at full power.

  18. Dynamic characteristics of azimuthally correlated structures of axial instability of wire-array Z pinches

    NASA Astrophysics Data System (ADS)

    Dan, Jia Kun; Huang, Xian Bin; Ren, Xiao Dong; Chen, Guang Hua; Xu, Qiang; Wang, Kun Lun; Ouyang, Kai; Wei, Bing

    2017-04-01

    Particular attention was placed on observations of dynamic properties of the azimuthally correlated structures of axial instability of wire-array Z pinches, which were conducted at 10-MA (for short circuit load) pulsed power generator-the Primary Test Stand facility. Not well fabricated loads, which were expected to preset bubble or spike in plasma, were used to degrade the implosion symmetry in order to magnify the phenomenon of instability. The side-view sequence of evolution of correlation given by laser shadowgraphy clearly demonstrates the dynamic processes of azimuthal correlation of the bubble and spike. A possible mechanism presented here suggests that it is the substantial current redistribution especially in regions surrounding the bubble/spike resulting from change of inductance due to the presence of the bubble/spike that plays an essential part in establishment of azimuthal correlation of wire array and liner Z pinches.

  19. Medical Abortion Provision by Pharmacies and Drug Sellers in Low- and Middle-Income Countries: A Systematic Review.

    PubMed

    Footman, Katharine; Keenan, Katherine; Reiss, Kate; Reichwein, Barbara; Biswas, Pritha; Church, Kathryn

    2018-03-01

    We undertook a systematic review to assess 1) the level and quality of pharmacy and drug shop provision of medical abortion (MA) in low- and middle-income countries (LMICs) and 2) interventions to improve quality of provision. We used standardized terms to search six databases for peer-reviewed and grey literature. We double-extracted data using a standardized template, and double-graded studies for methodological quality. We identified 22 studies from 16 countries reporting on level and quality of MA provision through pharmacies and drug sellers, and three intervention studies. Despite widespread awareness and provision of MA drugs, even in legally restricted contexts, most studies found that pharmacy workers and drug sellers had poor knowledge of effective regimens. Evidence on interventions to improve pharmacy and drug shop provision of MA was limited and generally low quality, but indicated that training could be effective in improving knowledge. Programmatic attention should focus on the development and rigorous evaluation of innovative interventions to improve women's access to information about MA self-management in low-and middle-income countries. © 2018 The Population Council, Inc.

  20. Zircon Trace Element Contents and Refined U-Pb Crystallization Ages for the Tatoosh Pluton, Mount Rainier National Park, Washington Cascades

    NASA Astrophysics Data System (ADS)

    Bacon, C. R.; Du Bray, E. A.; John, D. A.; Mazdab, F. K.; Wooden, J. L.

    2008-12-01

    The 7x12 km Tatoosh pluton south of Mount Rainier consists of 4 petrographic/compositional phases, here termed Nisqually, Reflection, Pyramid, and Stevens, that intrude Tertiary volcanic and sedimentary wall and roof rocks; contacts between the 4 intrusive units are rarely exposed. We used the USGS-Stanford SHRIMP- RG to analyze, in a continuous session, zircons from each of 6 quartz monzodiorite (qmd), quartz monzonite (qm), or granodiorite (grd) samples for 206Pb/238U ages and, concurrently, U, Th, Hf, and REE concentrations. A round-robin procedure yielded statistically robust geochronological results. Ages that we reported previously (FM07) were compromised by instrument instability and by calibration differences between analytical sessions. Between 11 and 31 new analyses of zircons from each sample were evaluated using the TuffZirc and Umix Ages routines of Isoplot 3.41 (Ludwig, 2003). TuffZirc solidification ages for the intrusions are: Nisqually grd (Paradise Valley; 65.4% SiO2) 17.29 +0.37/-0.24 Ma, Nisqually grd (Christine Falls; 66.4%) 17.70 +0.30/-0.16 Ma, Reflection qm (Pinnacle Peak trail; 66.6%) 18.38 +0.45/-0.28 Ma, Pyramid qmd (58.5%) 18.58 +0.20/-0.15 Ma, Stevens grd (Stevens Canyon; 67.8%) 19.15 +0.15/-0.12 Ma, and Stevens grd (south of Louise Lake; 69.3%) 19.20 +0.31/-0.26 Ma (U-Th initial-disequilibrium corrected, ±2σ). Precision of the U-Pb data limits rigorous identification of antecrysts to those with ages ~1 Myr > solidification ages. Antecryst ages that produce subsidiary modes in relative probability diagrams for the two Stevens samples give weighted mean values of 20.18 ±0.26 Ma and 20.07 ±0.18 Ma. Wide ranges in trace element concentrations and ratios indicate that many analyzed zircons grew in highly fractionated residual liquids in high-crystallinity environments. Concentrations of Th and U in Tatoosh zircons vary by two orders of magnitude, cores tend to have higher Th, U, and Th/U than rims, and overgrowths that fill reentrants have high U contents and low Th/U ratios. Chondrite-normalized REE patterns have familiar convex-up shapes with positive Ce and negative Eu anomalies: LaN = 0.03-6 (10 values >6 may reflect inclusions), YbN = 380-33,900, Ce/Ce* = 0.7-505, and Eu/Eu* = 0.06-1.25. Slopes of REE patterns increase subtly in the order Reflection < Pyramid ≤ Nisqually < Stevens. Fractionation of plagioclase + pyroxene and(or) amphibole + Fe-Ti oxide + apatite + zircon should produce relative-LREE- enriched successive liquids. Observed marginally steeper REE patterns (greater positive slopes) for rims, lower REE concentrations, and lower Th/U ratios may reflect co-precipitation of allanite ± thorite. Two parallel arrays in Eu/Eu* versus Hf, in which Eu/Eu* decreases as Hf increases, are consistent with growth of higher-Hf, lower-Eu/Eu* zircon from more evolved melts; separate arrays imply Nisqually and Pyramid + Reflection intrusions. Zircon Eu/Eu* and Hf in the Stevens granodiorite define one high-Eu/Eu* field and another similar to that for Pyramid and Reflection samples that imply more than one parental magma. The zircon ages indicate solidification in three episodes: Stevens ~19.2 Ma, Pyramid + Reflection ~18.5 Ma, and Nisqually ~17.5 Ma. An ~20.1 Ma stage is represented by antecrysts in Stevens samples. The source(s) of the pluton were active for at least ~2.7 Myr and major crystallization episodes were separated by intervals of 0.7-1.0 Myr.

  1. VCSELs for datacom applications

    NASA Astrophysics Data System (ADS)

    Wipiejewski, Torsten; Wolf, Hans-Dieter; Korte, Lutz; Huber, Wolfgang; Kristen, Guenter; Hoyler, Charlotte; Hedrich, Harald; Kleinbub, Oliver; Albrecht, Tony; Mueller, Juergen; Orth, Andreas; Spika, Zeljko; Lutgen, Stephan; Pflaeging, Hartwig; Harrasser, Joerg; Droegemueller, Karsten; Plickert, Volker; Kuhl, Detlef; Blank, Juergen; Pietsch, Doris; Stange, Herwig; Karstensen, Holger

    1999-04-01

    The use of oxide confined VCSELs in datacom applications is demonstrated. The devices exhibit low threshold currents of approximately 3 mA and low electrical series resistance of about 50 (Omega) . The emission wavelength is in the 850 nm range. Life times of the devices are several million hours under normal operating conditions. VCSEL arrays are employed in a high performance parallel optical link called PAROLITM. This optical ink provides 12 parallel channels with a total bandwidth exceeding 12 Gbit/s. The VCSELs optimized for the parallel optical link show excellent threshold current uniformity between channels of < 50 (mu) A. The array life time drops compared to a single device, but is still larger than 1 million hours.

  2. A Manually Operated, Advance Off-Stylet Insertion Tool for Minimally Invasive Cochlear Implantation Surgery

    PubMed Central

    Kratchman, Louis B.; Schurzig, Daniel; McRackan, Theodore R.; Balachandran, Ramya; Noble, Jack H.; Webster, Robert J.; Labadie, Robert F.

    2014-01-01

    The current technique for cochlear implantation (CI) surgery requires a mastoidectomy to gain access to the cochlea for electrode array insertion. It has been shown that microstereotactic frames can enable an image-guided, minimally invasive approach to CI surgery called percutaneous cochlear implantation (PCI) that uses a single drill hole for electrode array insertion, avoiding a more invasive mastoidectomy. Current clinical methods for electrode array insertion are not compatible with PCI surgery because they require a mastoidectomy to access the cochlea; thus, we have developed a manually operated electrode array insertion tool that can be deployed through a PCI drill hole. The tool can be adjusted using a preoperative CT scan for accurate execution of the advance off-stylet (AOS) insertion technique and requires less skill to operate than is currently required to implant electrode arrays. We performed three cadaver insertion experiments using the AOS technique and determined that all insertions were successful using CT and microdissection. PMID:22851233

  3. Freestanding eggshell membrane-based electrodes for high-performance supercapacitors and oxygen evolution reaction.

    PubMed

    Geng, Jing; Wu, Hao; Al-Enizi, Abdullah M; Elzatahry, Ahmed A; Zheng, Gengfeng

    2015-09-14

    A type of freestanding, light-weight eggshell membrane-based electrode is demonstrated for supercapacitors and for oxygen evolution reaction (OER) catalysis. As a widely available daily waste, eggshell membranes have unique porous three-dimensional grid-like fibrous structures with relatively high surface area and abundant macropores, allowing for effective conjugation of carbon nanotubes and growth of NiCo2O4 nanowire arrays, an effective supercapacitor material and OER catalyst. The three-dimensional fibrous eggshell membrane frameworks with carbon nanotubes offer efficient pathways for charge transport, and the macropores between adjacent fibers are fully accessible for electrolytes and bubble evolution. As a supercapacitor, the eggshell membrane/carbon nanotube/NiCo2O4 electrode shows high specific capacitances at current densities from 1 to 20 A g(-1), with excellent capacitance retention (>90%) at 10 A g(-1) for over 10,000 cycles. When employed as an OER catalyst, this eggshell membrane-based electrode exhibits an OER onset potential of 1.53 V vs. the reversible hydrogen electrode (RHE), and a stable catalytic current density of 20 mA cm(-2) at 1.65 V vs. the RHE.

  4. Rural Medicare Advantage Market Dynamics and Quality: Historical Context and Current Implications.

    PubMed

    Kemper, Leah; Barker, Abigail R; Wilber, Lyndsey; McBride, Timothy D; Mueller, Keith

    2016-07-01

    Purpose. In this policy brief, we assess variation in Medicare’s star quality ratings of Medicare Advantage (MA) plans that are available to rural beneficiaries. Evidence from the recent Centers for Medicare & Medicaid Services (CMS) quality demonstration suggests that market dynamics, i.e., firms entering and exiting the MA marketplace, play a role in quality improvement. Therefore, we also discuss how market dynamics may impact the smaller and less wealthy populations that are characteristic of rural places. Key Data Findings. (1) Highly rated MA plans serving rural Medicare beneficiaries are more likely to be health maintenance organizations (HMOs) and local preferred provider organizations (PPOs), as opposed to regional PPOs. HMOs and local PPOs may be better able to improve their quality scores strategically in response to the bonus payment incentive due to existing internal monitoring mechanisms. (2) On average, the rural enrollment rate is lower in plans with higher quality scores (59 percent) than the corresponding urban rate (71 percent). This differential is likely due, in part, to lack of availability of highly rated plans in rural areas: 17.8 percent of rural counties lacked access to a plan with four or more (out of five) stars, while just 3.7 percent of urban counties lacked such access. (3) MA plans with high quality scores have been operating longer, on average, and have a lower percentage of rural counties within their contract service areas than plans with lower quality scores.

  5. Comparison of X-ray Radiation Process in Single and Nested Wire Array Implosions

    NASA Astrophysics Data System (ADS)

    Li, Z. H.; Xu, Z. P.; Yang, J. L.; Xu, R. K.; Guo, C.; Grabovsky, E. V.; Oleynic, G. M.; Smirnov, V. P.

    2006-01-01

    In order to understanding the difference between tungsten single-wire-array and tungsten nested-wire-array Z-pinches, we have measured the x-ray power, the temporal-spatial distributions of x-ray radiation from each of the two loads. The measurements were performed with 0.1mm spatial and 1 ns temporal resolutions at 2.5- and 3.5-MA currents. The experimental conditions, including wire material, number of wires, wire-array length, electrode design, and implosion time, remained unchanged from shot to shot. Analysis of the radiation power profiles suggests that the nested-wire-array radiate slightly less x-ray energy in relatively shorter time interval than the single wire-array, leading to a much greater x-ray power in nested-wire-array implosion. The temporal-spatial distributions of x-ray power show that in both cases, plasmas formed by wire-array ablation radiate not simultaneously along load axis. For nested-wire-array Z-pinch, plasmas near the anode begin to radiate in 2ns later than that near the cathode. As a contrast, the temporal divergence of radiation among different plasma zones of single-wire-array Z-pinch along Z-axis is more than 6ns. Measurements of the x-ray emissions from small segments of pinch (2mm length along axis) indicate that local radiation power profiles almost do not vary for the two loads. Photographs taken by X-ray framing camera give a same description about the radiation process of pinch. One may expect that, as a result of this study, if the single-wire-array can be redesigned so ingeniously that the x-rays are emitted at the same time all over the pinch zone, the radiation power of single wire array Z-pinch may be much greater than what have been achieved.

  6. M&A For Lithography Of Sparse Arrays Of Sub-Micrometer Features

    DOEpatents

    Brueck, Steven R.J.; Chen, Xiaolan; Zaidi, Saleem; Devine, Daniel J.

    1998-06-02

    Methods and apparatuses are disclosed for the exposure of sparse hole and/or mesa arrays with line:space ratios of 1:3 or greater and sub-micrometer hole and/or mesa diameters in a layer of photosensitive material atop a layered material. Methods disclosed include: double exposure interferometric lithography pairs in which only those areas near the overlapping maxima of each single-period exposure pair receive a clearing exposure dose; double interferometric lithography exposure pairs with additional processing steps to transfer the array from a first single-period interferometric lithography exposure pair into an intermediate mask layer and a second single-period interferometric lithography exposure to further select a subset of the first array of holes; a double exposure of a single period interferometric lithography exposure pair to define a dense array of sub-micrometer holes and an optical lithography exposure in which only those holes near maxima of both exposures receive a clearing exposure dose; combination of a single-period interferometric exposure pair, processing to transfer resulting dense array of sub-micrometer holes into an intermediate etch mask, and an optical lithography exposure to select a subset of initial array to form a sparse array; combination of an optical exposure, transfer of exposure pattern into an intermediate mask layer, and a single-period interferometric lithography exposure pair; three-beam interferometric exposure pairs to form sparse arrays of sub-micrometer holes; five- and four-beam interferometric exposures to form a sparse array of sub-micrometer holes in a single exposure. Apparatuses disclosed include arrangements for the three-beam, five-beam and four-beam interferometric exposures.

  7. Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder.

    PubMed

    Roche, Daniel J O; Worley, Matthew J; Courtney, Kelly E; Bujarski, Spencer; London, Edythe D; Shoptaw, Steven; Ray, Lara A

    2017-07-01

    Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapies on this relationship has been examined. This secondary data analysis sought to examine (1) the predictive relationship between cue-induced craving and subsequent acute subjective response to methamphetamine (MA) and (2) whether the opioid-receptor antagonist naltrexone moderated this association in a sample of non-treatment-seeking individuals who met DSM-IV criteria for MA use disorder (abuse or dependence). Participants (n = 30) completed two 4-day medication regimens (oral naltrexone 50 mg or placebo, in a randomized, counterbalanced, and double-blind fashion). On day 4 of each medication regimen, participants completed a cue-reactivity paradigm followed by intravenous MA administration. Methamphetamine craving was assessed after the cue-reactivity paradigm, and subjective response to MA was assessed during MA infusion. Cue-induced craving for MA was positively associated with post-infusion subjective MA effects, including positive (i.e., stimulation, good effects, feel drug, high), negative (i.e., anxious and depressed), and craving-related (i.e., want more, would like access to drug, crave) responses. Naltrexone, vs. placebo, significantly reduced the association between cue-induced craving and positive subjective response to MA. The findings indicate that naltrexone moderates the predictive relationship between cue-induced craving and positive subjective effects of MA, thereby suggesting a behavioral mechanism by which naltrexone may be efficacious in treating MA use disorder.

  8. Solution Structure of Calmodulin Bound to the Binding Domain of the HIV-1 Matrix Protein*

    PubMed Central

    Vlach, Jiri; Samal, Alexandra B.; Saad, Jamil S.

    2014-01-01

    Subcellular distribution of calmodulin (CaM) in human immunodeficiency virus type-1 (HIV-1)-infected cells is distinct from that observed in uninfected cells. CaM co-localizes and interacts with the HIV-1 Gag protein in the cytosol of infected cells. Although it has been shown that binding of Gag to CaM is mediated by the matrix (MA) domain, the structural details of this interaction are not known. We have recently shown that binding of CaM to MA induces a conformational change that triggers myristate exposure, and that the CaM-binding domain of MA is confined to a region spanning residues 8–43 (MA-(8–43)). Here, we present the NMR structure of CaM bound to MA-(8–43). Our data revealed that MA-(8–43), which contains a novel CaM-binding motif, binds to CaM in an antiparallel mode with the N-terminal helix (α1) anchored to the CaM C-terminal lobe, and the C-terminal helix (α2) of MA-(8–43) bound to the N-terminal lobe of CaM. The CaM protein preserves a semiextended conformation. Binding of MA-(8–43) to CaM is mediated by numerous hydrophobic interactions and stabilized by favorable electrostatic contacts. Our structural data are consistent with the findings that CaM induces unfolding of the MA protein to have access to helices α1 and α2. It is noteworthy that several MA residues involved in CaM binding have been previously implicated in membrane binding, envelope incorporation, and particle production. The present findings may ultimately help in identification of the functional role of CaM in HIV-1 replication. PMID:24500712

  9. Bifunctional bamboo-like CoSe2 arrays for high-performance asymmetric supercapacitor and electrocatalytic oxygen evolution.

    PubMed

    Chen, Tian; Li, Songzhan; Gui, Pengbin; Wen, Jian; Fu, Xuemei; Fang, Guojia

    2018-05-18

    Bifunctional bamboo-like CoSe 2 arrays are synthesized by thermal annealing of Co(CO 3 ) 0.5 OH grown on carbon cloth in Se atmosphere. The CoSe 2 arrays obtained have excellent electrical conductivity, larger electrochemical active surface areas, and can directly serve as a binder-free electrode for supercapacitors and the oxygen evolution reaction (OER). When tested as a supercapacitor electrode, the CoSe 2 delivers a higher specific capacitance (544.6 F g -1 at current density of 1 mA cm -2 ) compared with CoO (308.2 F g -1 ) or Co 3 O 4 (201.4 F g -1 ). In addition, the CoSe 2 electrode possesses excellent cycling stability. An asymmetric supercapacitor (ASC) is also assembled based on bamboo-like CoSe 2 as a positive electrode and active carbon as a negative electrode in a 3.0 M KOH aqueous electrolyte. Owing to the unique stucture and good electrochemical performance of bamboo-like CoSe 2 , the as-assembled ACS can achieve a maximum operating voltage window of 1.7 V, a high energy density of 20.2 Wh kg -1 at a power density of 144.1 W kg -1 , and an outstanding cyclic stability. As the catalyst for the OER, the CoSe 2 exhibits a lower potential of 1.55 V (versus RHE) at current density of 10 mA cm -2 , a smaller Tafel slope of 62.5 mV dec -1 and an also outstanding stability.

  10. Bifunctional bamboo-like CoSe2 arrays for high-performance asymmetric supercapacitor and electrocatalytic oxygen evolution

    NASA Astrophysics Data System (ADS)

    Chen, Tian; Li, Songzhan; Gui, Pengbin; Wen, Jian; Fu, Xuemei; Fang, Guojia

    2018-05-01

    Bifunctional bamboo-like CoSe2 arrays are synthesized by thermal annealing of Co(CO3)0.5OH grown on carbon cloth in Se atmosphere. The CoSe2 arrays obtained have excellent electrical conductivity, larger electrochemical active surface areas, and can directly serve as a binder-free electrode for supercapacitors and the oxygen evolution reaction (OER). When tested as a supercapacitor electrode, the CoSe2 delivers a higher specific capacitance (544.6 F g‑1 at current density of 1 mA cm‑2) compared with CoO (308.2 F g‑1) or Co3O4 (201.4 F g‑1). In addition, the CoSe2 electrode possesses excellent cycling stability. An asymmetric supercapacitor (ASC) is also assembled based on bamboo-like CoSe2 as a positive electrode and active carbon as a negative electrode in a 3.0 M KOH aqueous electrolyte. Owing to the unique stucture and good electrochemical performance of bamboo-like CoSe2, the as-assembled ACS can achieve a maximum operating voltage window of 1.7 V, a high energy density of 20.2 Wh kg‑1 at a power density of 144.1 W kg‑1, and an outstanding cyclic stability. As the catalyst for the OER, the CoSe2 exhibits a lower potential of 1.55 V (versus RHE) at current density of 10 mA cm‑2, a smaller Tafel slope of 62.5 mV dec‑1 and an also outstanding stability.

  11. Core-shell solar cell fabrication using heterostructure of ZnO-nanowires arrays decorated with sputtered CdTe-nanoparticles

    NASA Astrophysics Data System (ADS)

    Akbarnejad, Elaheh; Dehghan Nayeri, Fatemeh; Ghoranneviss, Mahmood

    2018-03-01

    Core-shell heterostructures of ZnO-NWs/CdTe-NPs were fabricated through covering ZnO-NWs arrays using CdTe-NPs and the room temperature RF magnetron sputtering method. The influence of different CdTe-NPs deposition time (5, 20, 40 and 60 min) on the physical properties of core-shell heterostructures were investigated. In order to achieve the highest coverage level and a wide range of optical absorption at a visible range for a ZnO-NWs/CdTe-NPs (60 min) array, FTO/ZnO-NWs/CdTe-NPs (60 min)/Ni/Au core-shell solar cells were used. Solar cell fabrication was performed by soaking the samples in a saturated CdCl2 solution in methanol and a post-annealing treatment at 400 °C for 1 h in air which led to grain growth, the passivation of deep level defects, and the decrease of stacking faults. Short-circuit current and power conversion efficiency of the fabricated cell under illumination with visible light AM1.5 (100 mW cm-2) were 13.3 mA cm-2 and 3.41%, respectively. It was found that introducing a thin interfacial layer of CdSe to the configuration (FTO/ZnO-NWs/CdSe (10 nm)/CdTe-NPs (60 min)/Ni/Au) led to a 5.58% enhancement of photovoltaic performance of the solar cell (20.9 mA cm-2), which is 63.6% more than that of the same configuration without CdSe.

  12. 18. SITE BUILDING 002 SCANNER BUILDING VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. SITE BUILDING 002 - SCANNER BUILDING - VIEW OF SITE SECURITY OFFICE ACCESS DOOR FROM EXTERIOR OF OFFICE. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

  13. MaHog1, a Hog1-type mitogen-activated protein kinase gene, contributes to stress tolerance and virulence of the entomopathogenic fungus Metarhizium acridum.

    PubMed

    Jin, Kai; Ming, Yue; Xia, Yu Xian

    2012-12-01

    Fungal biocontrol agents have great potential in integrated pest management. However, poor efficacy and sensitivity to various adverse factors have hampered their wide application. In eukaryotic cells, Hog1 kinase plays a critical role in stress responses. In this study, MaHog1 (GenBank accession no. EFY85878), encoding a member of the Hog1/Sty1/p38 mitogen-activated protein kinase family in Metarhizium (Me.) acridum, was identified. Targeted gene disruption was used to analyse the role of MaHog1 in virulence and tolerance of adverse factors. Mutants with MaHog1 depletion showed increased sensitivity to high osmotic stress, high temperature and oxidative stress, and exhibited remarkable resistance to cell wall-disturbing agents. These results suggest that Hog1 kinase has a conserved function in regulating multistress responses among fungi, and that MaHog1 might influence cell wall biogenesis in Me. acridum. Bioassays conducted with topical inoculation and intrahaemocoel injection revealed that MaHog1 is required for both penetration and postpenetration development of Me. acridum. MaHog1 disruption resulted in a significant reduction in virulence, likely due to the combination of a decrease in conidial germination, a reduction in appressorium formation and a decline in growth rate in insect haemolymph, which might be caused by impairing fungal tolerance of various stresses during infection.

  14. Current scaling of radiated power for 40-mm diameter single wire arrays on Z

    NASA Astrophysics Data System (ADS)

    Nash, T. J.; Cuneo, M. E.; Spielman, R. B.; Chandler, G. A.; Leeper, R. J.; Seaman, J. F.; McGurn, J.; Lazier, S.; Torres, J.; Jobe, D.; Gilliland, T.; Nielsen, D.; Hawn, R.; Bailey, J. E.; Lake, P.; Carlson, A. L.; Seamen, H.; Moore, T.; Smelser, R.; Pyle, J.; Wagoner, T. C.; LePell, P. D.; Deeney, C.; Douglas, M. R.; McDaniel, D.; Struve, K.; Mazarakis, M.; Stygar, W. A.

    2004-11-01

    In order to estimate the radiated power that can be expected from the next-generation Z-pinch driver such as ZR at 28 MA, current-scaling experiments have been conducted on the 20 MA driver Z. We report on the current scaling of single 40 mm diameter tungsten 240 wire arrays with a fixed 110 ns implosion time. The wire diameter is decreased in proportion to the load current. Reducing the charge voltage on the Marx banks reduces the load current. On one shot, firing only three of the four levels of the Z machine further reduced the load current. The radiated energy scaled as the current squared as expected but the radiated power scaled as the current to the 3.52±0.42 power due to increased x-ray pulse width at lower current. As the current is reduced, the rise time of the x-ray pulse increases and at the lowest current value of 10.4 MA, a shoulder appears on the leading edge of the x-ray pulse. In order to determine the nature of the plasma producing the leading edge of the x-ray pulse at low currents further shots were taken with an on-axis aperture to view on-axis precursor plasma. This aperture appeared to perturb the pinch in a favorable manner such that with the aperture in place there was no leading edge to the x-ray pulses at lower currents and the radiated power scaled as the current squared ±0.75. For a full-current shot we will present x-ray images that show precursor plasma emitting on-axis 77 ns before the main x-ray burst.

  15. Dual-band polarization-/angle-insensitive metamaterial absorber

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiong, Han; Chongqing University, College of Communication Engineering, Chongqing, 400044; Zhong, Lin-Lin

    A dual-band metamaterial absorber (MA) based on triangular resonators is designed and investigated in this paper. It is composed of a two-dimensional periodic metal-dielectric-metal sandwiches array on a dielectric substrate. The simulation results clearly show that this absorber has two absorption peaks at 14.9 and 18.9 GHz, respectively, and experiments are conducted to verify the proposed designs effectively. For each polarization, the dual-band absorber is insensitive to the incident angle (up to 60°) and the absorption peaks remain high for both transverse electric (TE) and transverse magnetic (TM) radiation. To study the physical mechanism of power loss, the current distributionmore » at the dual absorption peaks is given. The MA proposed in this paper has potential applications in many scientific and martial fields.« less

  16. Compensation for z-directional non-uniformity of a monopole antenna at 7T MRI

    NASA Astrophysics Data System (ADS)

    Kim, Nambeom; Woo, Myung-Kyun; Kang, Chang-Ki

    2016-06-01

    The research was conducted to find ways to compensate for z-directional non-uniformity at a monopole antenna array (MA) coil by using a tilted optimized non-saturating excitation (TONE) pulse and to evaluate the feasibility of using the MA coil with the TONE pulse for anatomical and angiographic imaging. The sensitivity of a MA coil along the z-direction was measured by using an actual flip angle imaging pulse sequence with an oil phantom to evaluate the flip angle distributions of the MA coil for 7T magnetic resonance imaging (MRI). The effects on the z-directional uniformity were examined by using slow and fast TONE pulses, i.e., TONE SLOW and TONE FAST. T1- and T2* -weighted images of the human brain were also examined. The z-directional profiles of the TONE pulses were analyzed by using the average signal intensity throughout the brain. The effect of the TONE pulses on cerebral vessels was further examined by analyzing maximal intensity projections of T1-weighted images. With increasing the applied flip angles, the sensitivity slope slightly increased (0.044 per degree). For the MA coil, the TONE SLOWpulse yielded a compensated profile along the z-direction while the TONE HIGH pulse, which has a flat excitation profile along the z-direction, exhibited a tilted signal intensity toward the coil end, clearly indicating an intrinsic property of the MA coil. Similar to the phantom study, human brain images revealed z-directional symmetry around the peak value for the averaged signal intensity of the TONE SLOW pulse while the TONE HIGH pulse exhibited a tilted signal intensity toward the coil end. In vascular system imaging, the MA coil also clearly demonstrated a beneficial effect on the cerebral vessels, either with or without the TONE pulses. This study demonstrates that TONE pulses could compensate for the intrinsic z-directional non-uniformity of MA coils that exhibit strong uniformity in the x-y plane. Furthermore, tilted pulses, such as TONE pulses, were utilized for visualizing small vessels. Appropriately combining MA coils and TONE pulses could help advance micro-vessel visualization.

  17. The Marshall Grazing Incidence X-ray Spectrometer (MaGIXS)

    NASA Astrophysics Data System (ADS)

    Winebarger, A. R.; Savage, S. L.; Kobayashi, K.; Champey, P. R.; McKenzie, D. E.; Golub, L.; Testa, P.; Reeves, K.; Cheimets, P.; Cirtain, J. W.; Walsh, R. W.; Bradshaw, S. J.; Warren, H.; Mason, H. E.; Del Zanna, G.

    2017-12-01

    For over four decades, X-ray, EUV, and UV spectral observations have been used to measure physical properties of the solar atmosphere. At wavelengths below 10 nm, however, observations of the solar corona with simultaneous spatial and spectral resolution are limited, and not since the late 1970's have spatially resolved solar X-ray spectra been measured. Because the soft X-ray regime is dominated by emission lines formed at high temperatures, X-ray spectroscopic techniques yield insights to fundamental physical processes that are not accessible by any other means. Using a novel implementation of corrective optics, the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS) will measure, for the first time, the solar spectrum from 0.6- 2.4 nm with a 6 arcsec resolution over an 8 arcmin slit. The MaGIXS mission will address on of the fundamental problems of coronal physics: the nature of coronal heating. There are several observables in the MaGIXS wavelength range that will constrain the heating frequency and hence discriminate between competing coronal heating theories. In this presentation, we will present the MaGIXS scientific motivation and provide an update on instrument development. MaGIXS will be launched from White Sands Missile Range in the summer of 2019.

  18. Design of redundant array of independent DVD libraries based on iSCSI

    NASA Astrophysics Data System (ADS)

    Chen, Yupeng; Pan, Longfa

    2003-04-01

    This paper presents a new approach to realize the redundant array of independent DVD libraries (RAID-LoIP) by using the iSCSI technology and traditional RAID algorithms. Our design reaches the high performance of optical storage system with following features: large storage size, highly accessing rate, random access, long distance of DVD libraries, block I/O storage, long storage life. Our RAID-LoIP system can be a good solution for broadcasting media asset storage system.

  19. At-TAX: a whole genome tiling array resource for developmental expression analysis and transcript identification in Arabidopsis thaliana

    PubMed Central

    Laubinger, Sascha; Zeller, Georg; Henz, Stefan R; Sachsenberg, Timo; Widmer, Christian K; Naouar, Naïra; Vuylsteke, Marnik; Schölkopf, Bernhard; Rätsch, Gunnar; Weigel, Detlef

    2008-01-01

    Gene expression maps for model organisms, including Arabidopsis thaliana, have typically been created using gene-centric expression arrays. Here, we describe a comprehensive expression atlas, Arabidopsis thaliana Tiling Array Express (At-TAX), which is based on whole-genome tiling arrays. We demonstrate that tiling arrays are accurate tools for gene expression analysis and identified more than 1,000 unannotated transcribed regions. Visualizations of gene expression estimates, transcribed regions, and tiling probe measurements are accessible online at the At-TAX homepage. PMID:18613972

  20. 77 FR 22312 - Access by EPA Contractors to Confidential Business Information Related to the Greenhouse Gas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... you used. Provide specific examples to illustrate your concerns and suggest alternatives. Explain your... International subcontractors: Abt Associates, 55 Wheeler Street, Cambridge, MA 02138-1168; AMEC, 4021 Stirrup...

  1. An access to a library of novel triterpene derivatives with a promising pharmacological potential by Ugi and Passerini multicomponent reactions.

    PubMed

    Wiemann, Jana; Heller, Lucie; Csuk, René

    2018-04-25

    The promising combination of natural product leads and their derivatization by isocyanide-based multicomponent reactions (IMCRs) has gained interest in accessing diversity-oriented libraries with auspicious pharmacological potential. Therefore, a set of 34 Ugi and 3 Passerini products was successfully synthesized starting from naturally occurring triterpenoids, i.e. oleanolic acid (OA) and maslinic acid (MA), followed by a biological evaluation of the novel α-acylamino carboxamides and the α-acyloxy carboxamides in colorimetric SRB assays to determine their cytotoxic potential. Especially, the MA-Ugi products 6a, 6b and 7b showed a remarkable cytotoxicity for A2780 ovarian carcinoma cells in a low μM range. Compounds 6a and 7b induced programmed cell death in part through the apoptosis pathway. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  2. Combination of RNAseq and SNP nanofluidic array reveals the center of genetic diversity of cacao pathogen Moniliophthora roreri in the upper Magdalena Valley of Colombia and its clonality

    USDA-ARS?s Scientific Manuscript database

    Moniliophthora roreri is the fungal pathogen that causes frosty pod rot (FPR) disease of Theobroma cacao L., the source of chocolate. FPR occurs in most of the cacao producing countries in the Western Hemisphere, causing yield losses up to 80%. Genetic diversity within the FPR pathogen population ma...

  3. Hierarchical 3D NiFe2O4@MnO2 core-shell nanosheet arrays on Ni foam for high-performance asymmetric supercapacitors.

    PubMed

    Zhang, Xinyang; Zhang, Ziqing; Sun, Shuanggan; Sun, Qiushi; Liu, Xiaoyang

    2018-02-13

    Hierarchical NiFe 2 O 4 @MnO 2 core-shell nanosheet arrays (NSAs) were synthesized on Ni foam as an integrated electrode for supercapacitors, using a facile two-step hydrothermal method followed by calcination treatment. The NiFe 2 O 4 nanosheets were designed as the core and ultrathin MnO 2 nanoflakes as the shell, creating a unique three-dimensional (3D) hierarchical electrode on Ni foam. The composite electrode exhibited remarkable electrochemical performance with a high specific capacitance of 1391 F g -1 at a current density of 2 mA cm -2 and long cycling stability at a high current density of 10 mA cm -2 (only 11.4% loss after 3000 cycles). Additionally, an asymmetric supercapacitor (ASC) device was fabricated with a NiFe 2 O 4 @MnO 2 composite as the positive electrode material and activated carbon (AC) as the negative one. The ASC device exhibited a high energy density (45.2 W h kg -1 ) at a power density of 174 W kg -1 , and an excellent cycling stability over 3000 cycles with 92.5% capacitance retention. The remarkable electrochemical performance demonstrated its great potential as a promising candidate for high-performance supercapacitors.

  4. Comparative architecture of silks, fibrous proteins and their encoding genes in insects and spiders.

    PubMed

    Craig, Catherine L; Riekel, Christian

    2002-12-01

    The known silk fibroins and fibrous glues are thought to be encoded by members of the same gene family. All silk fibroins sequenced to date contain regions of long-range order (crystalline regions) and/or short-range order (non-crystalline regions). All of the sequenced fibroin silks (Flag or silk from flagelliform gland in spiders; Fhc or heavy chain fibroin silks produced by Lepidoptera larvae) are made up of hierarchically organized, repetitive arrays of amino acids. Fhc fibroin genes are characterized by a similar molecular genetic architecture of two exons and one intron, but the organization and size of these units differs. The Flag, Ser (sericin gene) and BR (Balbiani ring genes; both fibrous proteins) genes are made up of multiple exons and introns. Sequences coding for crystalline and non-crystalline protein domains are integrated in the repetitive regions of Fhc and MA exons, but not in the protein glues Ser1 and BR-1. Genetic 'hot-spots' promote recombination errors in Fhc, MA, and Flag. Codon bias, structural constraint, point mutations, and shortened coding arrays may be alternative means of stabilizing precursor mRNA transcripts. Differential regulation of gene expression and selective splicing of the mRNA transcript may allow rapid adaptation of silk functional properties to different physical environments.

  5. Hierarchical Core/Shell NiCo2O4@NiCo2O4 Nanocactus Arrays with Dual-functionalities for High Performance Supercapacitors and Li-ion Batteries.

    PubMed

    Cheng, Jinbing; Lu, Yang; Qiu, Kangwen; Yan, Hailong; Xu, Jinyou; Han, Lei; Liu, Xianming; Luo, Jingshan; Kim, Jang-Kyo; Luo, Yongsong

    2015-07-01

    We report the synthesis of three dimensional (3D) NiCo2O4@NiCo2O4 nanocactus arrays grown directly on a Ni current collector using a facile solution method followed by electrodeposition. They possess a unique 3D hierarchical core-shell structure with large surface area and dual-functionalities that can serve as electrodes for both supercapacitors (SCs) and lithium-ion batteries (LIBs). As the SC electrode, they deliver a remarkable specific capacitance of 1264 F g(-1) at a current density of 2 A g(-1) and ~93.4% of capacitance retention after 5000 cycles at 2 A g(-1). When used as the anode for LIBs, a high reversible capacity of 925 mA h g(-1) is achieved at a rate of 120 mA g(-1) with excellent cyclic stability and rate capability. The ameliorating features of the NiCo2O4 core/shell structure grown directly on highly conductive Ni foam, such as hierarchical mesopores, numerous hairy needles and a large surface area, are responsible for the fast electron/ion transfer and large active sites which commonly contribute to the excellent electrochemical performance of both the SC and LIB electrodes.

  6. Development and Calibration of a Field-Deployable Microphone Phased Array for Propulsion and Airframe Noise Flyover Measurements

    NASA Technical Reports Server (NTRS)

    Humphreys, William M., Jr.; Lockard, David P.; Khorrami, Mehdi R.; Culliton, William G.; McSwain, Robert G.; Ravetta, Patricio A.; Johns, Zachary

    2016-01-01

    A new aeroacoustic measurement capability has been developed consisting of a large channelcount, field-deployable microphone phased array suitable for airframe noise flyover measurements for a range of aircraft types and scales. The array incorporates up to 185 hardened, weather-resistant sensors suitable for outdoor use. A custom 4-mA current loop receiver circuit with temperature compensation was developed to power the sensors over extended cable lengths with minimal degradation of the signal to noise ratio and frequency response. Extensive laboratory calibrations and environmental testing of the sensors were conducted to verify the design's performance specifications. A compact data system combining sensor power, signal conditioning, and digitization was assembled for use with the array. Complementing the data system is a robust analysis system capable of near real-time presentation of beamformed and deconvolved contour plots and integrated spectra obtained from array data acquired during flyover passes. Additional instrumentation systems needed to process the array data were also assembled. These include a commercial weather station and a video monitoring / recording system. A detailed mock-up of the instrumentation suite (phased array, weather station, and data processor) was performed in the NASA Langley Acoustic Development Laboratory to vet the system performance. The first deployment of the system occurred at Finnegan Airfield at Fort A.P. Hill where the array was utilized to measure the vehicle noise from a number of sUAS (small Unmanned Aerial System) aircraft. A unique in-situ calibration method for the array microphones using a hovering aerial sound source was attempted for the first time during the deployment.

  7. Analysis of aldehydes in beer by gas-diffusion microextraction: characterization by high-performance liquid chromatography-diode-array detection-atmospheric pressure chemical ionization-mass spectrometry.

    PubMed

    Gonçalves, Luís Moreira; Magalhães, Paulo Jorge; Valente, Inês Maria; Pacheco, João Grosso; Dostálek, Pavel; Sýkora, David; Rodrigues, José António; Barros, Aquiles Araújo

    2010-06-11

    In this work, a recently developed extraction technique for sample preparation aiming the analysis of volatile and semi-volatile compounds named gas-diffusion microextraction (GDME) is applied in the chromatographic analysis of aldehydes in beer. Aldehydes-namely acetaldehyde (AA), methylpropanal (MA) and furfural (FA)-were simultaneously extracted and derivatized with 2,4-dinitrophenylhydrazine (DNPH), then the derivatives were separated and analyzed by high-performance liquid chromatography with spectrophotometric detection (HPLC-UV). The identity of the eluted compounds was confirmed by high-performance liquid chromatography-atmospheric pressure chemical ionization-mass-spectrometry detection in the negative ion mode (HPLC-APCI-MS). The developed methodology showed good repeatability (ca. 5%) and linearity as well as good limits of detection (AA-12.3, FA-1.5 and MA 5.4microgL(-1)) and quantification (AA-41, FA-4.9 and MA 18microgL(-1)); it also appears to be competitive in terms of speed and cost of analysis. Copyright 2010 Elsevier B.V. All rights reserved.

  8. Association of Antidementia Drugs and Mortality in Community-Dwelling Frail Older Patients With Dementia: The Role of Mortality Risk Assessment.

    PubMed

    Pilotto, Alberto; Polidori, Maria Cristina; Veronese, Nicola; Panza, Francesco; Arboretti Giancristofaro, Rosa; Pilotto, Andrea; Daragjati, Julia; Carrozzo, Eleonora; Prete, Camilla; Gallina, Pietro; Padovani, Alessandro; Maggi, Stefania

    2018-02-01

    To evaluate whether treatment with antidementia drugs is associated with reduced mortality in older patients with different mortality risk at baseline. Retrospective. Community-dwelling. A total of 6818 older people who underwent a Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA) evaluation to determine accessibility to homecare services or nursing home admission from 2005 to 2013 in the Padova Health District, Italy were included. Mortality risk at baseline was calculated by the Multidimensional Prognostic Index (MPI), based on information collected with the SVaMA. Participants were categorized to have mild (MPI-SVaMA-1), moderate (MPI-SVaMA-2), and high (MPI-SVaMA-3) mortality risk. Propensity score-adjusted hazard ratios (HR) of 2-year mortality were calculated according to antidementia drug treatment. Patients treated with antidementia drugs had a significant lower risk of death than untreated patients (HR 0.82; 95% confidence interval [CI] 0.73-0.92 and 0.56; 95% CI 0.49-0.65 for patients treated less than 2 years and more than 2 years treatment, respectively). After dividing patients according to their MPI-SVaMA grade, antidementia treatment was significantly associated with reduced mortality in the MPI-SVaMA-1 mild (HR 0.71; 95% CI 0.54-0.92) and MPI-SVaMA-2 moderate risk (HR 0.61; 95% CI 0.40-0.91, matched sample), but not in the MPI-SVaMA-3 high risk of death. This large community-dwelling patient study suggests that antidementia drugs might contribute to increased survival in older adults with dementia with lower mortality risk. Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

  9. Shear wave velocity structure in the lithosphere and asthenosphere across the Southern California continent and Pacific plate margin using inversion of Rayleigh wave data from the ALBACORE project.

    NASA Astrophysics Data System (ADS)

    Price, A. C.; Weeraratne, D. S.; Kohler, M. D.; Rathnayaka, S.; Escobar, L., Sr.

    2015-12-01

    The North American and Pacific plate boundary is a unique example of past subduction of an oceanic spreading center which has involved oceanic plate capture and inception of a continental transform boundary that juxtaposes continental and oceanic lithosphere on a single plate. The amphibious ALBACORE seismic project (Asthenospheric and Lithospheric Broadband Architecture from the California Offshore Region Experiment) deployed 34 ocean bottom seismometers (OBS) on 15-35 Ma seafloor and offers a unique opportunity to compare the LAB in continental and oceanic lithosphere in one seismic study. Rayleigh waves were recorded simultaneously by our offshore array and 82 CISN network land stations from 2010-2011. Here we predict phase velocities for a starting shear wave velocity model for each of 5 regions in our study area and compare to observed phase velocities from our array in a least-squares sense that produces the best fit 1-D shear wave velocity structure for each region. Preliminary results for the deep ocean (seafloor 25-32 Ma) indicates high velocities reaching 4.5 km/s at depths of 50 km associated with the lithosphere for seafloor 25-32 Ma. A negative velocity gradient is observed below this which reaches a minimum of 4.0 km/s at 160 km depth. The mid-ocean region (age 13-25 Ma) indicates a slightly lower magnitude and shallower LVZ. The Inner Borderland displays the highest lithospheric velocities offshore reaching 4.8 km/s at 40 km depth indicating underplating. The base of the LVZ in the Borderland increases sharply from 4.0 km/s to 4.5 km/s at 80-150 km depth indicating partial melt and compositional changes. The LVZ displays a very gradual positive velocity gradient in all other regions such as the deep seafloor and continent reaching 4.5 km/s at 300 km depth. The deep ocean, Borderlands, and continental region each have unique lithospheric velocities, LAB depths, and LVZ character that indicate stark differences in mantle structure that occur on a single plate as well as across the continental margin.

  10. Hydrogeologic Unit Flow Characterization Using Transition Probability Geostatistics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jones, N L; Walker, J R; Carle, S F

    2003-11-21

    This paper describes a technique for applying the transition probability geostatistics method for stochastic simulation to a MODFLOW model. Transition probability geostatistics has several advantages over traditional indicator kriging methods including a simpler and more intuitive framework for interpreting geologic relationships and the ability to simulate juxtapositional tendencies such as fining upwards sequences. The indicator arrays generated by the transition probability simulation are converted to layer elevation and thickness arrays for use with the new Hydrogeologic Unit Flow (HUF) package in MODFLOW 2000. This makes it possible to preserve complex heterogeneity while using reasonably sized grids. An application of themore » technique involving probabilistic capture zone delineation for the Aberjona Aquifer in Woburn, Ma. is included.« less

  11. Compactly packaged monolithic four-wavelength VCSEL array with 100-GHz wavelength spacing for future-proof mobile fronthaul transport.

    PubMed

    Lee, Eun-Gu; Mun, Sil-Gu; Lee, Sang Soo; Lee, Jyung Chan; Lee, Jong Hyun

    2015-01-12

    We report a cost-effective transmitter optical sub-assembly using a monolithic four-wavelength vertical-cavity surface-emitting laser (VCSEL) array with 100-GHz wavelength spacing for future-proof mobile fronthaul transport using the data rate of common public radio interface option 6. The wavelength spacing is achieved using selectively etched cavity control layers and fine current adjustment. The differences in operating current and output power for maintaining the wavelength spacing of four VCSELs are <1.4 mA and <1 dB, respectively. Stable operation performance without mode hopping is observed, and error-free transmission under direct modulation is demonstrated over a 20-km single-mode fiber without any dispersion-compensation techniques.

  12. 78 FR 9588 - Drawbridge Operation Regulations; Saugus River, Lynn and Revere, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... scaffolding be attached to the bascule lift span to access work area. DATES: This deviation is effective from... facilitate rehabilitation of the bridge towers that requires scaffolding be attached to the bascule lift span...

  13. 8. Historic American Buildings Survey Reproduced from the collections of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Reproduced from the collections of the Library of Congress, Accession No. 45041 Geographical File ('Nantucket, Mass.') Division of Prints and Photographs c. 1880 - Jethro Coffin House, Sunset Hill, Nantucket, Nantucket County, MA

  14. Chasing the Late Jurassic APW Monster Shift in Ontario Kimberlites

    NASA Astrophysics Data System (ADS)

    Kent, D. V.; Muttoni, G.; Gee, J. S.; Kjarsgaard, B. A.

    2012-12-01

    A 30° gap was recognized in a composite APW path when global poles from predominantly igneous rocks were assembled in North American coordinates using plate reconstructions (Kent & Irving 2010 JGR). The 'monster shift' occurred between a 160-190 Ma cluster of mean poles at 75-80°N 90-110°E to a 140-145 Ma grouping centered at 60-65°N ~200°E. There are hardly any intermediate igneous poles whereas the rather divergent directions from the Late Jurassic Morrison Formation published by Steiner & Helsley (1975 GSA Bulletin) are subject to adjustments for Colorado Plateau rotation and sedimentary inclination error, neither of which are precisely known for this redbed unit sampled in Colorado. On the other hand, similar large rapid swings have been recognized in the Late Jurassic APW path for Adria (Channell et al. 2010 Paleo3), suggesting a global phenomena. In an effort to fill the data gap between ~145 and 160 Ma, we sampled accessible outcrops/subcrops of kimberlites in the Timiskaming area of Ontario, Canada, that are associated with high precision U-Pb perovskite ages (Heamon & Kjarsgaard 2000 EPSL). We report initial results from two of the intrusions: the 153.6±2.4 Ma Peddie kimberlite from outcrop and the Triple B kimberlite that was accessible by trenching and is assumed to be the same age as the nearby 153.7±1.8 Ma Seed kimberlite as delineated by aeromagnetic surveys and borings. Systematic progressive thermal demagnetization indicated in each unit a dominant characteristic component with unblocking temperatures to 575° that presumably reflect a magnetite carrier that will be checked by further rock magnetic experiments. Samples from the Peddie kimberlite had stable downward (normal polarity) magnetizations whose mean direction gives a paleopole at 73°N 184°E. In contrast, samples from the Triple B kimberlite have upward (reverse polarity) magnetizations with a well-grouped direction whose (north) paleopole is 78°N 197°E, proximal to the Peddie pole. The normal and reverse polarities suggest that sufficient time elapsed between emplacement of the Triple B and Peddie to give an opportunity to average secular variation. The combined ~154 Ma Triple B and Peddie pole encouragingly lies about halfway between igneous poles from North America nearest in age: the 169 Ma Moat volcanics and the 142 Ma Ithaca kimberlites. However, preliminary paleomagnetic results from some of the other sampled kimberlite bodies are more problematical and require further paleomagnetic and geochronological work.

  15. Multi-terabyte EIDE disk arrays running Linux RAID5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanders, D.A.; Cremaldi, L.M.; Eschenburg, V.

    2004-11-01

    High-energy physics experiments are currently recording large amounts of data and in a few years will be recording prodigious quantities of data. New methods must be developed to handle this data and make analysis at universities possible. Grid Computing is one method; however, the data must be cached at the various Grid nodes. We examine some storage techniques that exploit recent developments in commodity hardware. Disk arrays using RAID level 5 (RAID-5) include both parity and striping. The striping improves access speed. The parity protects data in the event of a single disk failure, but not in the case ofmore » multiple disk failures. We report on tests of dual-processor Linux Software RAID-5 arrays and Hardware RAID-5 arrays using a 12-disk 3ware controller, in conjunction with 250 and 300 GB disks, for use in offline high-energy physics data analysis. The price of IDE disks is now less than $1/GB. These RAID-5 disk arrays can be scaled to sizes affordable to small institutions and used when fast random access at low cost is important.« less

  16. Medicare Advantage Members' Expected Out-Of-Pocket Spending For Inpatient And Skilled Nursing Facility Services.

    PubMed

    Keohane, Laura M; Grebla, Regina C; Mor, Vincent; Trivedi, Amal N

    2015-06-01

    Inpatient and skilled nursing facility (SNF) cost sharing in Medicare Advantage (MA) plans may reduce unnecessary use of these services. However, large out-of-pocket expenses potentially limit access to care and encourage beneficiaries at high risk of needing inpatient and postacute care to avoid or leave MA plans. In 2011 new federal regulations restricted inpatient and skilled nursing facility cost sharing and mandated limits on out-of-pocket spending in MA plans. After these regulations, MA members in plans with low premiums averaged $1,758 in expected out-of-pocket spending for an episode of seven hospital days and twenty skilled nursing facility days. Among members with the same low-premium plan in 2010 and 2011, 36 percent of members belonged to plans that added an out-of-pocket spending limit in 2011. However, these members also had a $293 increase in average cost sharing for an inpatient and skilled nursing facility episode, possibly to offset plans' expenses in financing out-of-pocket limits. Some MA beneficiaries may still have difficulty affording acute and postacute care despite greater regulation of cost sharing. Project HOPE—The People-to-People Health Foundation, Inc.

  17. Medicare Advantage Members’ Expected Out-Of-Pocket Spending For Inpatient And Skilled Nursing Facility Services

    PubMed Central

    Keohane, Laura M.; Grebla, Regina C.; Mor, Vincent; Trivedi, Amal N.

    2015-01-01

    Inpatient and skilled nursing facility (SNF) cost sharing in Medicare Advantage (MA) plans may reduce unnecessary use of these services. However, large out-of-pocket expenses potentially limit access to care and encourage beneficiaries at high risk of needing inpatient and postacute care to avoid or leave MA plans. In 2011 new federal regulations restricted inpatient and skilled nursing facility cost sharing and mandated limits on out-of-pocket spending in MA plans. After these regulations, MA members in plans with low premiums averaged $1,758 in expected out-of-pocket spending for an episode of seven hospital days and twenty skilled nursing facility days. Among members with the same low-premium plan in 2010 and 2011, 36 percent of members belonged to plans that added an out-of-pocket spending limit in 2011. However, these members also had a $293 increase in average cost sharing for an inpatient and skilled nursing facility episode, possibly to offset plans’ expenses in financing out-of-pocket limits. Some MA beneficiaries may still have difficulty affording acute and postacute care despite greater regulation of cost sharing. PMID:26056208

  18. Writing and applications of fiber Bragg grating arrays

    NASA Astrophysics Data System (ADS)

    LaRochelle, Sophie; Cortes, Pierre-Yves; Fathallah, H.; Rusch, Leslie A.; Jaafar, H. B.

    2000-12-01

    Multiple Bragg gratings are written in a single fibre strand with accurate positioning to achieve predetermined time delays between optical channels. Applications of fibre Bragg grating arrays include encoders/decoders with series of identical gratings for optical code-division multiple access.

  19. Uncoordinated MAC for Adaptive Multi Beam Directional Networks: Analysis and Evaluation

    DTIC Science & Technology

    2016-08-01

    control (MAC) policies for emerging systems that are equipped with fully digital antenna arrays which are capable of adaptive multi-beam directional...Adaptive Beam- forming, Multibeam, Directional Networking, Random Access, Smart Antennas I. INTRODUCTION Fully digital beamforming antenna arrays that...are capable of adaptive multi-beam communications are quickly becoming a reality. These antenna arrays allow users to form multiple simultaneous

  20. Hydrothermally formed three-dimensional hexagon-like P doped Ni(OH)2 rod arrays for high performance all-solid-state asymmetric supercapacitors

    NASA Astrophysics Data System (ADS)

    Li, Kunzhen; Li, Shikuo; Huang, Fangzhi; Lu, Yan; Wang, Lei; Chen, Hong; Zhang, Hui

    2018-01-01

    Three dimensional hexagon-like phosphrous (P) doped Ni(OH)2 rod arrays grown on Ni foam (NF) are fabricated by a facile and green one-step hydrothermal process. Ni foam is only reacted in a certain concentration of P containing H2O2 aqueous solution. The possible growth mechanism of the P doped Ni(OH)2 rod arrays is discussed. As a battery-type electrode material in situ formed on Ni foam, the binder-free P doped Ni(OH)2 rod arrays electrode displays a ultrahigh specific areal capacitance of 2.11C cm-2 (3.51 F cm-2) at 2 mA cm-2, and excellent cycling stability (95.5% capacitance retention after 7500 cycles). The assembled all-solid-state asymmetric supercapacitor (AAS) based on such P doped Ni(OH)2 rod arrays as the positive electrode and activated carbon as the negative electrode achieves an energy density of 81.3 Wh kg-1 at the power density of 635 W kg-1. The AAS device also exhibits excellent practical performance, which can easily drive an electric fan (3 W rated power) when two AAS devices are assembled in series. Thus, our synthesized P doped Ni(OH)2 rod arrays has a lot of potential applications in future energy storage prospects.

  1. In situ fabrication of Ni-Co (oxy)hydroxide nanowire-supported nanoflake arrays and their application in supercapacitors.

    PubMed

    Zheng, Xiaoyu; Quan, Honglin; Li, Xiaoxin; He, Hai; Ye, Qinglan; Xu, Xuetang; Wang, Fan

    2016-09-29

    Three-dimensional (3D) hybrid nanostructured arrays grown on a flexible substrate have recently attracted great attention owing to their potential application as supercapacitor electrodes in portable and wearable electronic devices. Here, we report an in situ conversion of Ni-Co active electrode materials for the fabrication of high-performance electrodes. Ni-Co carbonate hydroxide nanowire arrays on carbon cloth were initially synthesized via a hydrothermal method, and they were gradually converted to Ni-Co (oxy)hydroxide nanowire-supported nanoflake arrays after soaking in an alkaline solution. The evolution of the supercapacitor performance of the soaked electrode was investigated in detail. The areal capacitance increases from 281 mF cm -2 at 1 mA cm -2 to 3710 and 3900 mF cm -2 after soaking for 36 h and 48 h, respectively. More interestingly, the electrode also shows an increased capacitance with charge/discharge cycles due to the long-time soaking in KOH solution, suggesting novel cycling durability. The enhancement in capacitive performance should be related to the formation of a unique nanowire-supported nanoflake array architecture, which controls the agglomeration of nanoflakes, making them fully activated. As a result, the facile in situ fabrication of the hybrid architectural design in this study provides a new approach to fabricate high-performance Ni/Co based hydroxide nanostructure arrays for next-generation energy storage devices.

  2. Basis of Ionospheric Modification by High-Frequency Waves

    DTIC Science & Technology

    2007-06-01

    for conducting ionospheric heating experiments in Gakona, Alaska, as part of the High Frequency Active Auroral Research Program ( HAARP ) [5], is being...upgraded. The upgraded HAARP HF transmitting system will be a phased-array antenna of 180 elements. Each element is a cross dipole, which radiates a...supported by the High Frequency Active Auroral Research Program ( HAARP ), the Air Force Research Laboratory at Hanscom Air Force Base, MA, and by the Office

  3. TGF-Beta Antibody for Prostate Cancer: Role of ERK

    DTIC Science & Technology

    2012-07-01

    medicine has been used either as a major medication or as a supplement either for cancer prevention or for cancer treatment. These herbal products...Blot Analysis ell lysates were prepared by using cell lysis buffer (Cell Sig- aling, Danvers, MA) supplemented with 1 mM PMSF and 1% rotease inhibitor...of target protein was used. Negative controls were identical array sections stained in the absence of primary antibody. (TIF) Method S1 Supplemental

  4. Self-Cohering Airborne Distributed Array

    DTIC Science & Technology

    1988-06-01

    F19628-84- C -0080 ft. ADDRESS (City, State, and ZIP Code) 10. SOURCE OF FUNDING NUMBERS PROGRAM PROJECT JTASK JWORK UNIT Hanscom APE MA 01731-5000...algorithms under consideration (including the newly developed algorithms). The algorithms are classified both according to the type c -f processing and...4.1 RADIO CAMERA DATA FORMAT AND PROCEDURES (FROM C -23) The range trace delivered by each antenna element is stonred as a rc’w of coimplex number-s

  5. Lowering data retention voltage in static random access memory array by post fabrication self-improvement of cell stability by multiple stress application

    NASA Astrophysics Data System (ADS)

    Mizutani, Tomoko; Takeuchi, Kiyoshi; Saraya, Takuya; Kobayashi, Masaharu; Hiramoto, Toshiro

    2018-04-01

    We propose a new version of the post fabrication static random access memory (SRAM) self-improvement technique, which utilizes multiple stress application. It is demonstrated that, using a device matrix array (DMA) test element group (TEG) with intrinsic channel fully depleted (FD) silicon-on-thin-buried-oxide (SOTB) six-transistor (6T) SRAM cells fabricated by the 65 nm technology, the lowering of data retention voltage (DRV) is more effectively achieved than using the previously proposed single stress technique.

  6. U-Pb systematics of zircon and titanite from the Gardnos impact structure, Norway: Evidence for impact at 546 Ma?

    NASA Astrophysics Data System (ADS)

    Kalleson, E.; Corfu, F.; Dypvik, H.

    2009-05-01

    Zircon and titanite were investigated in impactites of the Gardnos structure, a crater formed in Sveconorwegian (ca. 1 Ga) crust, which was then overridden in the Devonian by Caledonian nappes. Observed deformation features in zircons are granular texture, planar microstructures, and likely the incorporation of organic carbon during impact causing black staining of the zircon grains. The grains were studied by scanning electron microscopy (SEM) and cathode luminescence (CL) and dated by U-Pb isotope dilution - thermo-ionization mass spectrometry (ID-TIMS). Zircon grains without impact related features have U-Pb data showing moderate discordance (5-13%) and indicating formation ages mostly in the range of 1600-1000 Ma, except detrital zircon ages as old as >2481 Ma, reflecting the diversity of target rocks in the area. Titanite with concordant ages of 995-999 Ma dates metamorphism during final juxtaposition of the Telemarkia on the Idefjorden terrane to the east. Zircon grains with demonstrated or presumed shock features yield highly discordant (14-40%) U-Pb data, with a majority of them plotting along an array with a lower intercept of about 340 Ma reflecting the influence of the Caledonian orogeny and recent Pb-loss. One zircon grain was totally reset at 379 Ma during late Caledonian metamorphism, which also caused local growth of new titanite. A specific group of zircon grains yields data with relatively high discordance for moderate U contents, and five of these analyses, including that of a grain with proven granular or aggregate texture, fit a discordia line with an upper intercept of 546 ± 5 Ma. These features are interpreted as indicating zircon break-down to an amorphous state during impact, with subsequent recrystallization into microcrystalline aggregates causing extensive to complete Pb loss. We further suggest that their crystallinity prevented Pb loss during the Caledonian orogeny, while the small subgrain size and increasing metamictisation allowed more recent disturbances. We thus interpret the 546 Ma age as the approximate time of impact.

  7. Volcano-tectonic evolution of the Western Afar margin: new geochronological and structural data

    NASA Astrophysics Data System (ADS)

    Stab, Martin; Pik, Raphael; Bellahsen, Nicolas; Leroy, Sylvie; Ayalew, Dereje; Denèle, Yoann

    2013-04-01

    The rift system in NW-Afar (Ethiopia) is part of the Nubia-Somalia-Arabia triple junction located above the Afar hot spot active mainly since Oligocene times. It represents a unique natural laboratory for field study of superficial and deep lithospheric structure and process interactions during the transition between rifting and oceanic spreading in magma-rich setting. Most past field studies in Afar focused on the recognition and correlation of Afar's volcano-stratigraphic record and led to models of margin development that stress out the major trends of volcanic structures and give accordingly the following chronological "big picture". (1) 2km-thick flood basalt province emplaced at ca. 30 Ma due to hot spot activity over Jurassic to Permian sedimentary rocks and basement. (2) Rifting started around 25-20 Ma with half graben and great escarpment formation along with localization of volcanic activity in highly faulted narrower basins followed by lithospheric flexure. (3) The deformation migrated toward the rift centre with the emplacement around 8-5 Ma of bi-modal volcanics later faulted. (4) A second pulse of flood-basalt, the so-called Stratoid series, started at 4 Ma, until 1 Ma. In this contribution, we present new structural field data and lavas (U-Th/He) datings along a cross-section from the marginal graben to the Manda-Hararo active rift axis. In the newly explored Sullu Adu ranges, which were previously thought to be made of 8 Ma Dahla Basalts Fm., we mapped normal faults arrays affecting a complex magmatic series. We dated highly tilted 30 Ma pre-rift basic and silicic volcanic rocks that are unconformably overlain by syn-rift volcanics (25 to 8 Ma). This pattern is in some places either masked by unconformable thick stratoid cover or strongly eroded by dense river drainage. However, it is preserved enough to suggest a lower-than-expected extension ratio and/or the presence of major normal faults controlling seaward-dipping reflectors (SDR) emplacement such as the one observed on seismic reflection profiles in North and South Atlantic volcanic margins.

  8. Production and characterization of thermoplastic cassava starch, functionalized poly(lactic acid), and their reactive compatibilized blends

    NASA Astrophysics Data System (ADS)

    Detyothin, Sukeewan

    Cassava starch was blended with glycerol using a co-rotating twin-screw extruder (TSE). Thermoplastic cassava starch (TPCS) at a ratio of 70/30 by weight of cassava/glycerol was selected and further blended with other polymers. TPCS sheets made from compression molding had low tensile strength (0.45 +/- 0.05 MPa) and Young's modulus (1.24 +/- 0.58 MPa), but moderate elongation at break (83.0 +/- 0.18.6%), medium level of oxygen permeability, and high water vapor permeability with a very high rate of water absorption. TPCS was blended with poly(lactic acid) (PLA) at various ratios by using a TSE. The blend resins exhibited good properties such as increased thermal stability (Tmax) and crystallinity of PLA, and improved water sensitivity and processability of TPCS. PLA and TPCS exhibited a high interfacial tension between the two phases of 7.9 mJ·m -2, indicating the formation of an incompatible, immiscible blend. SEM micrographs showed a non-homogeneous distribution of TPCS droplets in the PLA continuous phase. TEM micrographs of the blend films made by cast-film extrusion showed coalescence of the TPCS droplets in the PLA continuous phase of the blend, indicating that the compatibility between the polymer pair needs to be improved. A response surface methodology (RSM) design was used to analyze the effects of maleic anhydride (MA) and 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane (Luperox or L101) contents, and TSE screw speed on the degree of grafted MA and number average molecular weight (Mn) of functionalized PLA (PLA-g-MA), a reactive compatibilizer. PLA-g- MA made by reactive extrusion had an array of colors depending on the content of L101 and MA used. New FTIR peaks suggested that MA was grafted onto the PLA backbone and oligomeric MA may occur. Increasing L101 increased the degree of grafting and decreased Mn, but the Mn of the PLA-g-MA's produced with a high amount of L101 was stable during storage. MA exhibited an optimum concentration for maximizing the degree of grafted MA, and increasing MA content retarded the reduction of Mn during processing. However, the Mn of PLA-g-MA during storage decreased more rapidly with a high content of MA. TSE screw speed had an impact on the Mn with the maximum value predicted at 20 rpm. PLA-g-MA compounds differing in Mn and/or grafted MA content were used as reactive polymers with TPCS (to produce binary blends) and as reactive compatibilizers (to produce ternary blends of PLA/TPCS/PLA-g-MA) with TPCS content of 30 wt% using a TSE. As a result of maleation, PLA-g-MA had a higher grafted MA content with a lower Mn, and higher PI. The interaction of anhydride groups from PLA-g-MA and hydroxyl groups from TPCS was found by FTIR. The reactive binary blends exhibited a change in thermal stability, decrease of Tcc, the presence of double melting peaks, and an increase of the Tgs of glycerol and starch. The higher the grafted MA content and/or the higher Mn of the PLA- g-MA used, the better were the distribution and smaller the TPCS domains obtained in the blends. The highest elongation at break was achieved when 30 wt% TPCS was blended with 70 wt% of PLA having 0.1 wt% of grafted MA and Mn of PLA-g-MA with a 45 kDa. Finally, the optimum PLA-g-MA was determined by using the results from PLA-g-MA RSM design and the reactive blending.

  9. Spatially resolved single crystal x-ray spectropolarimetry of wire array z-pinch plasmas

    NASA Astrophysics Data System (ADS)

    Wallace, M. S.; Haque, S.; Neill, P.; Pereira, N. R.; Presura, R.

    2018-01-01

    A recently developed single-crystal x-ray spectropolarimeter has been used to record paired sets of polarization-dependent and axially resolved x-ray spectra emitted by wire array z-pinches. In this measurement, two internal planes inside a suitable crystal diffract the x-rays into two perpendicular directions that are normal to each other, thereby separating incident x-rays into their linearly polarized components. This paper gives considerations for fielding the instrument on extended sources. Results from extended sources are difficult to interpret because generally the incident x-rays are not separated properly by the crystal. This difficulty is mitigated by using a series of collimating slits to select incident x-rays that propagate in a plane of symmetry between the polarization-splitting planes. The resulting instrument and some of the spatially resolved polarized x-ray spectra recorded for a 1-MA aluminum wire array z-pinch at the Nevada Terawatt Facility at the University of Nevada, Reno will be presented.

  10. Spatially resolved single crystal x-ray spectropolarimetry of wire array z-pinch plasmas.

    PubMed

    Wallace, M S; Haque, S; Neill, P; Pereira, N R; Presura, R

    2018-01-01

    A recently developed single-crystal x-ray spectropolarimeter has been used to record paired sets of polarization-dependent and axially resolved x-ray spectra emitted by wire array z-pinches. In this measurement, two internal planes inside a suitable crystal diffract the x-rays into two perpendicular directions that are normal to each other, thereby separating incident x-rays into their linearly polarized components. This paper gives considerations for fielding the instrument on extended sources. Results from extended sources are difficult to interpret because generally the incident x-rays are not separated properly by the crystal. This difficulty is mitigated by using a series of collimating slits to select incident x-rays that propagate in a plane of symmetry between the polarization-splitting planes. The resulting instrument and some of the spatially resolved polarized x-ray spectra recorded for a 1-MA aluminum wire array z-pinch at the Nevada Terawatt Facility at the University of Nevada, Reno will be presented.

  11. Study of ablation and implosion stages in wire arrays using coupled ultraviolet and X-ray probing diagnostics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anderson, A. A.; Ivanov, V. V.; Astanovitskiy, A. L.

    2015-11-15

    Star and cylindrical wire arrays were studied using laser probing and X-ray radiography at the 1-MA Zebra pulse power generator at the University of Nevada, Reno. The Leopard laser provided backlighting, producing a laser plasma from a Si target which emitted an X-ray probing pulse at the wavelength of 6.65 Å. A spherically bent quartz crystal imaged the backlit wires onto X-ray film. Laser probing diagnostics at the wavelength of 266 nm included a 3-channel polarimeter for Faraday rotation diagnostic and two-frame laser interferometry with two shearing interferometers to study the evolution of the plasma electron density at the ablation and implosionmore » stages. Dynamics of the plasma density profile in Al wire arrays at the ablation stage were directly studied with interferometry, and expansion of wire cores was measured with X-ray radiography. The magnetic field in the imploding plasma was measured with the Faraday rotation diagnostic, and current was reconstructed.« less

  12. Hermitian symmetry free optical-single-carrier frequency division multiple access for visible light communication

    NASA Astrophysics Data System (ADS)

    Azim, Ali W.; Le Guennec, Yannis; Maury, Ghislaine

    2018-05-01

    Optical-orthogonal frequency division multiplexing (O-OFDM) is an effective scheme for visible light communications (VLC), offering a candid extension to multiple access (MA) scenarios, i.e., O-OFDMA. However, O-OFDMA exhibits high peak-to-average power ratio (PAPR), which exacerbates the non-linear distortions from the light emitting diode (LED). To overcome high PAPR while sustaining MA, optical-single-carrier frequency-division multiple access (O-SCFDMA) is used. For both O-OFDMA and O-SCFDMA, Hermitian symmetry (HS) constraint is imposed in frequency-domain (FD) to obtain a real-valued time-domain (TD) signal for intensity modulation-direct detection (IM-DD) implementation of VLC. Howbeit, HS results in an increase of PAPR for O-SCFDMA. In this regard, we propose HS free (HSF) O-SCFDMA (HSFO-SCFDMA). We compare HSFO-SCFDMA with several approaches in key parameters, such as, bit error rate (BER), optical power penalty, PAPR, quantization, electrical power efficiency and system complexity. BER performance and optical power penalty is evaluated considering multipath VLC channel and taking into account the bandwidth limitation of LED in combination with its optimized driver. It is illustrated that HSFO-SCFDMA outperforms other alternatives.

  13. A Web Server for MACCS Magnetometer Data

    NASA Technical Reports Server (NTRS)

    Engebretson, Mark J.

    1998-01-01

    NASA Grant NAG5-3719 was provided to Augsburg College to support the development of a web server for the Magnetometer Array for Cusp and Cleft Studies (MACCS), a two-dimensional array of fluxgate magnetometers located at cusp latitudes in Arctic Canada. MACCS was developed as part of the National Science Foundation's GEM (Geospace Environment Modeling) Program, which was designed in part to complement NASA's Global Geospace Science programs during the decade of the 1990s. This report describes the successful use of these grant funds to support a working web page that provides both daily plots and file access to any user accessing the worldwide web. The MACCS home page can be accessed at http://space.augsburg.edu/space/MaccsHome.html.

  14. Integrated semiconductor-magnetic random access memory system

    NASA Technical Reports Server (NTRS)

    Katti, Romney R. (Inventor); Blaes, Brent R. (Inventor)

    2001-01-01

    The present disclosure describes a non-volatile magnetic random access memory (RAM) system having a semiconductor control circuit and a magnetic array element. The integrated magnetic RAM system uses CMOS control circuit to read and write data magnetoresistively. The system provides a fast access, non-volatile, radiation hard, high density RAM for high speed computing.

  15. Random-access technique for modular bathymetry data storage in a continental shelf wave refraction program

    NASA Technical Reports Server (NTRS)

    Poole, L. R.

    1974-01-01

    A study was conducted of an alternate method for storage and use of bathymetry data in the Langley Research Center and Virginia Institute of Marine Science mid-Atlantic continental-shelf wave-refraction computer program. The regional bathymetry array was divided into 105 indexed modules which can be read individually into memory in a nonsequential manner from a peripheral file using special random-access subroutines. In running a sample refraction case, a 75-percent decrease in program field length was achieved by using the random-access storage method in comparison with the conventional method of total regional array storage. This field-length decrease was accompanied by a comparative 5-percent increase in central processing time and a 477-percent increase in the number of operating-system calls. A comparative Langley Research Center computer system cost savings of 68 percent was achieved by using the random-access storage method.

  16. Open-access microfluidic patch-clamp array with raised lateral cell trapping sites.

    PubMed

    Lau, Adrian Y; Hung, Paul J; Wu, Angela R; Lee, Luke P

    2006-12-01

    A novel open-access microfluidic patch-clamp array chip with lateral cell trapping sites raised above the bottom plane of the chip was developed by combining both a microscale soft-lithography and a macroscale polymer fabrication method. This paper demonstrates the capability of using such an open-access fluidic system for patch-clamp measurements. The surface of the open-access patch-clamp sites prepared by the macroscale hole patterning method of soft-state elastic polydimethylsiloxane (PDMS) is examined; the seal resistances are characterized and correlated with the aperture dimensions. Whole cell patch-clamp measurements are carried out with CHO cells expressing Kv2.1 ion channels. Kv2.1 ion channel blocker (TEA) dosage response is characterized and the binding activity is examined. The results demonstrate that the system is capable of performing whole cell measurements and drug profiling in a more efficient manner than the traditional patch-clamp set-up.

  17. John F. Kennedy National Historic Site General Management Plan support : transportation study

    DOT National Transportation Integrated Search

    2010-09-01

    This report provides an overview of transportation and access issues related to the John F. Kennedy National Historic Site and the surrounding area in Brookline, MA. The study defines transportation-related goals for the site and provides support for...

  18. Underground

    ERIC Educational Resources Information Center

    Vrchota, Janet

    1974-01-01

    At a time when the future of New York's subway system looked bleak, new underground zoning legislation (the first ever) has been enacted. This new law requires buildings constructed near a subway station to provide transit easement space to allow public access to the subway through the building property. (MA)

  19. Ultrasonic Array for Obstacle Detection Based on CDMA with Kasami Codes

    PubMed Central

    Diego, Cristina; Hernández, Álvaro; Jiménez, Ana; Álvarez, Fernando J.; Sanz, Rebeca; Aparicio, Joaquín

    2011-01-01

    This paper raises the design of an ultrasonic array for obstacle detection based on Phased Array (PA) techniques, which steers the acoustic beam through the environment by electronics rather than mechanical means. The transmission of every element in the array has been encoded, according to Code Division for Multiple Access (CDMA), which allows multiple beams to be transmitted simultaneously. All these features together enable a parallel scanning system which does not only improve the image rate but also achieves longer inspection distances in comparison with conventional PA techniques. PMID:22247675

  20. GaN nanowire arrays with nonpolar sidewalls for vertically integrated field-effect transistors

    NASA Astrophysics Data System (ADS)

    Yu, Feng; Yao, Shengbo; Römer, Friedhard; Witzigmann, Bernd; Schimpke, Tilman; Strassburg, Martin; Bakin, Andrey; Schumacher, Hans Werner; Peiner, Erwin; Suryo Wasisto, Hutomo; Waag, Andreas

    2017-03-01

    Vertically aligned gallium nitride (GaN) nanowire (NW) arrays have attracted a lot of attention because of their potential for novel devices in the fields of optoelectronics and nanoelectronics. In this work, GaN NW arrays have been designed and fabricated by combining suitable nanomachining processes including dry and wet etching. After inductively coupled plasma dry reactive ion etching, the GaN NWs are subsequently treated in wet chemical etching using AZ400K developer (i.e., with an activation energy of 0.69 ± 0.02 eV and a Cr mask) to form hexagonal and smooth a-plane sidewalls. Etching experiments using potassium hydroxide (KOH) water solution reveal that the sidewall orientation preference depends on etchant concentration. A model concerning surface bonding configuration on crystallography facets has been proposed to understand the anisotropic wet etching mechanism. Finally, NW array-based vertical field-effect transistors with wrap-gated structure have been fabricated. A device composed of 99 NWs exhibits enhancement mode operation with a threshold voltage of 1.5 V, a superior electrostatic control, and a high current output of >10 mA, which prevail potential applications in next-generation power switches and high-temperature digital circuits.

  1. GaN nanowire arrays with nonpolar sidewalls for vertically integrated field-effect transistors.

    PubMed

    Yu, Feng; Yao, Shengbo; Römer, Friedhard; Witzigmann, Bernd; Schimpke, Tilman; Strassburg, Martin; Bakin, Andrey; Schumacher, Hans Werner; Peiner, Erwin; Wasisto, Hutomo Suryo; Waag, Andreas

    2017-03-03

    Vertically aligned gallium nitride (GaN) nanowire (NW) arrays have attracted a lot of attention because of their potential for novel devices in the fields of optoelectronics and nanoelectronics. In this work, GaN NW arrays have been designed and fabricated by combining suitable nanomachining processes including dry and wet etching. After inductively coupled plasma dry reactive ion etching, the GaN NWs are subsequently treated in wet chemical etching using AZ400K developer (i.e., with an activation energy of 0.69 ± 0.02 eV and a Cr mask) to form hexagonal and smooth a-plane sidewalls. Etching experiments using potassium hydroxide (KOH) water solution reveal that the sidewall orientation preference depends on etchant concentration. A model concerning surface bonding configuration on crystallography facets has been proposed to understand the anisotropic wet etching mechanism. Finally, NW array-based vertical field-effect transistors with wrap-gated structure have been fabricated. A device composed of 99 NWs exhibits enhancement mode operation with a threshold voltage of 1.5 V, a superior electrostatic control, and a high current output of >10 mA, which prevail potential applications in next-generation power switches and high-temperature digital circuits.

  2. GaN-based micro-LED arrays on flexible substrates for optical cochlear implants

    NASA Astrophysics Data System (ADS)

    Goßler, Christian; Bierbrauer, Colin; Moser, Rüdiger; Kunzer, Michael; Holc, Katarzyna; Pletschen, Wilfried; Köhler, Klaus; Wagner, Joachim; Schwaerzle, Michael; Ruther, Patrick; Paul, Oliver; Neef, Jakob; Keppeler, Daniel; Hoch, Gerhard; Moser, Tobias; Schwarz, Ulrich T.

    2014-05-01

    Currently available cochlear implants are based on electrical stimulation of the spiral ganglion neurons. Optical stimulation with arrays of micro-sized light-emitting diodes (µLEDs) promises to increase the number of distinguishable frequencies. Here, the development of a flexible GaN-based micro-LED array as an optical cochlear implant is reported for application in a mouse model. The fabrication of 15 µm thin and highly flexible devices is enabled by a laser-based layer transfer process of the GaN-LEDs from sapphire to a polyimide-on-silicon carrier wafer. The fabricated 50 × 50 µm2 LEDs are contacted via conducting paths on both p- and n-sides of the LEDs. Up to three separate channels could be addressed. The probes, composed of a linear array of the said µLEDs bonded to the flexible polyimide substrate, are peeled off the carrier wafer and attached to flexible printed circuit boards. Probes with four µLEDs and a width of 230 µm are successfully implanted in the mouse cochlea both in vitro and in vivo. The LEDs emit 60 µW at 1 mA after peel-off, corresponding to a radiant emittance of 6 mW mm-2.

  3. Primary experimental results of wire-array Z-pinches on PTS

    NASA Astrophysics Data System (ADS)

    Huang, X. B.; Zhou, S. T.; Ren, X. D.; Dan, J. K.; Wang, K. L.; Zhang, S. Q.; Li, J.; Xu, Q.; Cai, H. C.; Duan, S. C.; Ouyang, K.; Chen, G. H.; Ji, C.; Wang, M.; Feng, S. P.; Yang, L. B.; Xie, W. P.; Deng, J. J.

    2014-12-01

    The Primary Test Stand (PTS) developed at the China Academy of Engineering Physics is a multiterawatt pulsed power driver, which can deliver a ˜10 MA, 70 ns rise-time (10%-90%) current to a short circuit load and has important applications in Z-pinch driven inertial confinement fusion and high energy density physics. In this paper, primary results of tungsten wire-array Z-pinch experiments on PTS are presented. The load geometries investigated include 15-mm-tall cylindrical single and nested arrays with diameter ranging from 14.4-26.4 mm, and consisting of 132˜276 tungsten wires with 5˜10 μm in diameter. Multiple diagnostics were fielded to determine the characteristics of x-ray radiations and to obtain self-emitting images of imploding plasmas. X-ray power up to 80 TW with ˜3 ns FWMH is achieved by using nested wire arrays. The total x-ray energy exceeds 500 kJ and the peak radiation temperature is about 150 eV. Typical velocity of imploding plasmas goes around 3˜5×107 cm/s and the radial convergence ratio is between 10 and 20.

  4. A phylogenetic analysis of the grape genus (Vitis L.) reveals broad reticulation and concurrent diversification during neogene and quaternary climate change.

    PubMed

    Wan, Yizhen; Schwaninger, Heidi R; Baldo, Angela M; Labate, Joanne A; Zhong, Gan-Yuan; Simon, Charles J

    2013-07-05

    Grapes are one of the most economically important fruit crops. There are about 60 species in the genus Vitis. The phylogenetic relationships among these species are of keen interest for the conservation and use of this germplasm. We selected 309 accessions from 48 Vitis species,varieties, and outgroups, examined ~11 kb (~3.4 Mb total) of aligned nuclear DNA sequences from 27 unlinked genes in a phylogenetic context, and estimated divergence times based on fossil calibrations. Vitis formed a strongly supported clade. There was substantial support for species and less for the higher-level groupings (series). As estimated from extant taxa, the crown age of Vitis was 28 Ma and the divergence of subgenera (Vitis and Muscadinia) occurred at ~18 Ma. Higher clades in subgenus Vitis diverged 16 - 5 Ma with overlapping confidence intervals, and ongoing divergence formed extant species at 12 - 1.3 Ma. Several species had species-specific SNPs. NeighborNet analysis showed extensive reticulation at the core of subgenus Vitis representing the deeper nodes, with extensive reticulation radiating outward. Fitch Parsimony identified North America as the origin of the most recent common ancestor of extant Vitis species. Phylogenetic patterns suggested origination of the genus in North America, fragmentation of an ancestral range during the Miocene, formation of extant species in the late Miocene-Pleistocene, and differentiation of species in the context of Pliocene-Quaternary tectonic and climatic change. Nuclear SNPs effectively resolved relationships at and below the species level in grapes and rectified several misclassifications of accessions in the repositories. Our results challenge current higher-level classifications, reveal the abundance of genetic diversity in the genus that is potentially available for crop improvement, and provide a valuable resource for species delineation, germplasm conservation and use.

  5. Intra- and intertrench variations in flexural bending of the Manila, Mariana and global trenches: implications on plate weakening in controlling trench dynamics

    NASA Astrophysics Data System (ADS)

    Zhang, Fan; Lin, Jian; Zhou, Zhiyuan; Yang, Hongfeng; Zhan, Wenhuan

    2018-02-01

    We conducted detailed analyses of a global array of trenches, revealing systematic intra- and intertrench variations in plate bending characteristics. The intratrench variations of the Manila and Mariana Trenches were analysed in detail as end-member cases of the relatively young (16-36 Ma) and old (140-160 Ma) subducting plates, respectively. Meanwhile, the intertrench variability was investigated for a global array of additional trenches including the Philippine, Kuril, Japan, Izu-Bonin, Aleutian, Tonga-Kermadec, Middle America, Peru, Chile, Sumatra and Java Trenches. Results of the analysis show that the trench relief (W0) and width (X0) of all systems are controlled primarily by the faulting-reduced elastic thickness near the trench axis (Tem) and affected only slightly by the initial unfaulted thickness (TeM) of the incoming plate. The reduction in Te has caused significant deepening and narrowing of trench valleys. For the cases of relatively young or old plates, the plate age could be a dominant factor in controlling the trench bending shape, regardless the variations in axial loadings. Our calculations also show that the axial loading and stresses of old subducting plates can vary significantly along the trench axis. In contrast, the young subducting plates show much smaller values and variations in axial loading and stresses.

  6. 22. VIEW ACROSS UPPER LEVEL OF EAST BUILDING TOWARDS THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. VIEW ACROSS UPPER LEVEL OF EAST BUILDING TOWARDS THE SOUTH (RIVER) SHOWING ROOF TRUSSES, PLANK AND PATTERN STORAGE, HINGED ACCESS HATCH TO STREET LEVEL SHOP CAN BE SEEN OPENED IN FOREGROUND. - Lowell's Boat Shop, 459 Main Street, Amesbury, Essex County, MA

  7. Medicare program; revisions to the Medicare Advantage and Part D prescription drug contract determinations, appeals, and intermediate sanctions processes. Final rule with comment period.

    PubMed

    2007-12-05

    This rule with comment period finalizes the Medicare program provisions relating to contract determinations involving Medicare Advantage (MA) organizations and Medicare Part D prescription drug plan sponsors, including eliminating the reconsideration process for review of contract determinations, revising the provisions related to appeals of contract determinations, and clarifying the process for MA organizations and Part D plan sponsors to complete corrective action plans. In this final rule with comment period, we also clarify the intermediate sanction and civil money penalty (CMP) provisions that apply to MA organizations and Medicare Part D prescription drug plan sponsors, modify elements of their compliance plans, retain voluntary self-reporting for Part D sponsors and implement a voluntary self-reporting recommendation for MA organizations, and revise provisions to ensure HHS has access to the books and records of MA organizations and Part D plan sponsors' first tier, downstream, and related entities. Although we have decided not to finalize the mandatory self-reporting provisions that we proposed, CMS remains committed to adopting a mandatory self-reporting requirement. To that end, we are requesting comments that will assist CMS in crafting a future proposed regulation for a mandatory self-reporting requirement.

  8. Dose measurement based on threshold shift in MOSFET arrays in commercial SRAMS

    NASA Technical Reports Server (NTRS)

    Scheick, L. Z.; Swift, G.

    2002-01-01

    A new method using an array of MOS transistors isdescribed for measuring dose absorbed from ionizingradiation. Using the array of MOSFETs in a SRAM, a direct measurement of the number of MOS cells which change as a function of applied bias on the SRAM. Since the input and output of a SRAM used as a dosimeter is completely digital, the measurement of dose is easily accessible by a remote processing system.

  9. Compression of an Applied Bz field by a z-pinch onto a Tamped DT Fiber for Inertial Confinement Fusion

    NASA Astrophysics Data System (ADS)

    Nash, Tom

    2009-11-01

    Simulations of a z-pinch compressing an applied 100 kG Bz field onto an on-axis DT fiber tamped with beryllium show the field reaching over 100 MG in the tamp, sufficient to confine DT alpha particles and to form a thermal barrier. The barrier allows the DT plasma to burn at a rho*r value as low as 0.045 g/cm^2, and at temperatures over 50 keV for a 63 MA drive current. Driving currents between 21 and 63 MA are considered with cryogenic DT fiber diameters between 600 μm and 1.6 mm. Pinch implosion times are 120 ns with a peak implosion velocity of 35 cm/μs. 1D simulations are of a foil pinch, but for improved stability we propose a nested wire-array. Simulated fusion yields with this system scale as the sixth power of the current, with burn fractions scaling as the fourth power of the current. At 63 MA the simulated yield is 521 MJ from 4.2 mg/cm of DT with a 37% burn fraction at a rho*r of only 0.18 g/cm^2.

  10. Dendritic-metasurface-based flexible broadband microwave absorbers

    NASA Astrophysics Data System (ADS)

    Wang, Mei; Weng, Bin; Zhao, Jing; Zhao, Xiaopeng

    2017-06-01

    Based on the dendritic metasurface model, a type of flexible and lightweight microwave absorber (MA) comprising resistance film array with dendritic slot (RFADS), dielectric material, and metal plate is proposed. A broadband absorptivity of >80% is obtained both from simulation and experiment at frequency ranges of 3.0-9.2 and 3.2-9.00 GHz, respectively. And the thickness of MA is 5 mm, which is only 0.05λ _{low}, or 0.15λ _ {high}, where the λ _{low} and the λ _{high} are the beginning and the end of the working frequency. By combining this metasurface-based MA with the dendritic-resistance-film-based microwave metasurface absorber (MMA), we designed a broadband MMA. The simulations and experiments showed that this kind of MMA can absorb the radiation effectively at a wide frequency range 4.5-17.5 GHz. And the thickness of this combined MMA is 4 mm. All the structures showed their insensitivity to the incident angle (0°-40°) and the polarization of the incident wave because of their structural symmetry. In addition, the small thickness, low apparent density, and flexibility made those structures possess the advantages of being applied in microwave stealth and radar cross-section (RCS) reduction.

  11. Combination of electromagnetic measurements and FEM simulations for nondestructive determination of mechanical hardness

    NASA Astrophysics Data System (ADS)

    Gabi, Yasmine; Martins, Olivier; Wolter, Bernd; Strass, Benjamin

    2018-04-01

    The paper considers the Rockwell hardness investigation by finite element simulation in inspection situation of press hardened parts using the 3MA non-destructive testing system. The FEM model is based on robust strategy calculation which manages the issues of geometry and the time multiscale, as well as the local nonlinear hysteresis behavior of ferromagnetic materials. 3MA simulations are performed at high level operating point in order to saturate the soft microscopic surface soft layer of press hardened steel and access mainly to the bulk properties. 3MA measurements are validated by comparison with numerical simulations. Based on the simulation outputs, a virtual calibration is run. This result constitutes the first validation; the simulated calibration is in agreement with the conventional experimental data. As an outstanding highlight a correlation between magnetic quantities and hardness can be described via FEM simulated signals and shows high accuracy to the measured results.

  12. A Simple Solution to Providing Remote Access to CD-ROM.

    ERIC Educational Resources Information Center

    Garnham, Carla T.; Brodie, Kent

    1990-01-01

    A pilot project at the Medical College of Wisconsin illustrates how even small computing organizations with limited financial and staff resources can provide remote access to CD-ROM (Compact Disc-Read-Only-Memory) databases, and that providing such convenient access to a vast array of useful information can greatly benefit faculty and students.…

  13. A 34K SNP genotyping array for Populus trichocarpa: design, application to the study of natural populations and transferability to other Populus species.

    PubMed

    Geraldes, A; Difazio, S P; Slavov, G T; Ranjan, P; Muchero, W; Hannemann, J; Gunter, L E; Wymore, A M; Grassa, C J; Farzaneh, N; Porth, I; McKown, A D; Skyba, O; Li, E; Fujita, M; Klápště, J; Martin, J; Schackwitz, W; Pennacchio, C; Rokhsar, D; Friedmann, M C; Wasteneys, G O; Guy, R D; El-Kassaby, Y A; Mansfield, S D; Cronk, Q C B; Ehlting, J; Douglas, C J; Tuskan, G A

    2013-03-01

    Genetic mapping of quantitative traits requires genotypic data for large numbers of markers in many individuals. For such studies, the use of large single nucleotide polymorphism (SNP) genotyping arrays still offers the most cost-effective solution. Herein we report on the design and performance of a SNP genotyping array for Populus trichocarpa (black cottonwood). This genotyping array was designed with SNPs pre-ascertained in 34 wild accessions covering most of the species latitudinal range. We adopted a candidate gene approach to the array design that resulted in the selection of 34 131 SNPs, the majority of which are located in, or within 2 kb of, 3543 candidate genes. A subset of the SNPs on the array (539) was selected based on patterns of variation among the SNP discovery accessions. We show that more than 95% of the loci produce high quality genotypes and that the genotyping error rate for these is likely below 2%. We demonstrate that even among small numbers of samples (n = 10) from local populations over 84% of loci are polymorphic. We also tested the applicability of the array to other species in the genus and found that the number of polymorphic loci decreases rapidly with genetic distance, with the largest numbers detected in other species in section Tacamahaca. Finally, we provide evidence for the utility of the array to address evolutionary questions such as intraspecific studies of genetic differentiation, species assignment and the detection of natural hybrids. © 2013 Blackwell Publishing Ltd.

  14. ELECTRON MICROSCOPY OF MITOSIS IN AMEBAE

    PubMed Central

    Roth, L. E.

    1967-01-01

    The mitotic apparatus (MA) of the giant ameba, Chaos carolinensis, has characteristic sequences of microtubule arrays and deployment of nuclear envelope fragments. If mitotic organisms are subjected to 2°C for 5 min, the MA microtubules are completely degraded, and the envelope fragments are released from the chromosomes which remain condensed but lose their metaphase-plate orientation. On warming, microtubules reform but show partial loss of their parallel alignment; displacement of the envelope fragments persists or is increased by microtubule reformation. This study demonstrates that cooling causes destruction of microtubules and intermicrotubular cross-bonds and further shows that such controlled dissolution and reformation can provide an in vivo test sequence for studies on the effects of inhibitor-compounds on microtubule subunit aggregation. Urea, at the comparatively low concentration of 0.8 M, inhibited reformation following cooling and rewarming but was ineffective in altering microtubules that had formed before treatment. PMID:6040537

  15. Evolution of Nd and Pb isotopes in Central Pacific seawater from ferromanganese crusts

    USGS Publications Warehouse

    Ling, H.F.; Burton, K.W.; O'Nions, R. K.; Kamber, B.S.; Von Blanckenburg, F.; Gibb, A.J.; Hein, J.R.

    1997-01-01

    Hydrogenetic ferromanganese crusts incorporate elements from ambient seawater during their growth on seamounts. By analysing Nd, Pb and Be isotope profiles within crusts it is possible to reconstruct seawater tracer histories. Depth profiles of 10Be/9Be ratios in three Pacific ferromanganese crusts have been used to obtain growth rates which are between 1.4 and 3.8 mm/Ma. Nd and Pb isotopes provide intact records of isotopic variations in Pacific seawater over the last 20 Ma or more. There were only small changes in Pb isotope composition in the last 20 Ma. This indicates a constant Pb composition for the erosional sources and suggests further that erosional Nd inputs may have been uniform too. ??ND values vary considerably with time and most probably reflect changes in ocean circulation. The ??ND values of the crusts not only vary as a function of age but also as a function of water depth. From 25 to 0 Ma, crust VA13/2 from 4.8 km water depth has a similar pattern of ??ND variation to the two shallower crusts from 1.8 and 2.3 km, but about 1.0 to 1.5 units more negative. This suggests that ??ND stratification in Pacific seawater, as demonstrated for the present day, has been maintained for at least 20 Ma. Each crust shows a decrease in ??ND from 3-5 Ma to the present, which is interpreted in terms of an increase in the NADW component present in the Pacific. From 10 to 3-5 Ma ago the crusts show an increase in ??ND. This suggests a decreasing role for a deep water source with ??ND less than circum-Pacific sources. In this regard the Panamanian gateway restriction from ???10 Ma with final closure at 3-5 Ma may have played an important role in reducing access of Atlantic-derived Nd to the Pacific.

  16. Microscopic diffusion anisotropy in the human brain: Age-related changes.

    PubMed

    Lawrenz, Marco; Brassen, Stefanie; Finsterbusch, Jürgen

    2016-11-01

    The fractional anisotropy (FA) that can be derived from diffusion tensor imaging (DTI), is ambiguous because it not only depends on the tissue microstructure but also on the axon or fiber orientation distribution within a voxel. Measures of the microscopic diffusion anisotropy, like the microscopic anisotropy index (MA) that can be determined with so-called double-wave-vector (DWV) or double diffusion encoding (DDE) imaging, are independent of this orientation distribution and, thus, offer a more direct and undisguised access to the tissue structure on a cellular or microscopic scale. In this study, FA and MA measurements were performed in a group of aged (>60y), healthy volunteers and compared to the data obtained recently for a group of young (<33y), healthy volunteers to reveal age-related differences. The coefficients-of-variation (CV) determined for the aged group were considerably lower for MA than for FA in average and in most of the 16 ROIs analyzed due to lower between-subject variations of MA. FA differences between the young and the aged group were in line with previous DTI studies. MA was also decreased in the aged group but in more of the 16 ROIs and with a higher significance. Furthermore, MA differences were also observed in frontal brain regions containing fiber crossings that did not reveal significant FA differences, i.e. MA seems to provide a better sensitivity to detect microstructural changes in such regions. In some non-cortical gray matter structures like the putamen, FA was increased but MA was decreased in the aged group which could indicate a coherent fiber orientation in the aged group related to the loss of crossing or fanning fibers. In conclusion, MA not only could improve the detectability of differences of the tissue microstructure but, in conjunction with FA, could also help to identify the underlying changes. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. KAPSE (Kernel ADA Programming Support Environment) Interface Team Public Report. Volume 5.

    DTIC Science & Technology

    1985-08-01

    Computer Nons , April 1964. e The K Ma policy statent mde the Language Control Fcility Newsletter for the Ada Jovial Wmkng Group. e There will be a CRIS...cre-ed, the initial access control inA-mIion my be splied by the ACCSS parmeter. If non -nll, this parumter speci fi the initia access tolicontr olti...assigned, or controlled by the operating system to &,.sure consistent and non -conflicting usage by programs under execution. Examples of resources

  18. Positioning Medical Assistants for a Greater Role in the Era of Health Reform.

    PubMed

    Chapman, Susan A; Marks, Angela; Dower, Catherine

    2015-10-01

    Medical assistants (MAs) are one of the fastest-growing occupations in the United States. As of 2014 there were about 585,000 MAs in the United States, and the Bureau of Labor Statistics projected the MA workforce to grow by 29% from 2012 to 2022. The MA population is primarily female, ethnically and racially diverse, and paid about $15.01 per hour. MAs are primarily educated in private schools, many at for-profit institutions. The MA curriculum and length of training can be quite varied and can lead to uneven preparation for practice. Traditionally, the MA role has involved a limited clinical role and little involvement with team care, particularly in larger practices or clinics. Medical groups, clinics, and health systems are now taking a new look at MAs and how they can play a greater role in reforming health care delivery models. Expanded roles for MAs might include health coach, referral coordinator, disease registry manager, and health screener using protocols. In expanding MA roles, education and regulatory issues need to be addressed by the provider community including current inconsistent regulation and certification requirements and the lack of preparation for expanded roles in traditional MA training programs. MAs are well positioned to help address challenges in the health care delivery system including improving access to care while reducing overall cost. Successful model practices using MAs in expanded roles need further formal evaluation and replication across practice settings.

  19. Juvenile Moyamoya and Craniosynostosis in a Child with Deletion 1p32p31: Expanding the Clinical Spectrum of 1p32p31 Deletion Syndrome and a Review of the Literature

    PubMed Central

    Prontera, Paolo; Rogaia, Daniela; Mencarelli, Amedea; Ottaviani, Valentina; Guercini, Giorgio; Bersano, Anna; Stangoni, Gabriela

    2017-01-01

    Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterised by the progressive occlusion of the internal carotid artery. Its aetiology is uncertain, but a genetic background seems likely, given the high MA familial rate. To investigate the aetiology of craniosynostosis and juvenile moyamoya in a 14-year-old male patient, we performed an array-comparative genomic hybridisation revealing a de novo interstitial deletion of 8.5 Mb in chromosome region 1p32p31. The deletion involved 34 protein coding genes, including NF1A, whose haploinsufficiency is indicated as being mainly responsible for the 1p32-p31 chromosome deletion syndrome phenotype (OMIM 613735). Our patient also has a deleted FOXD3 of the FOX gene family of transcription factors, which plays an important role in neural crest cell growth and differentiation. As the murine FOXD3−/− model shows craniofacial anomalies and abnormal common carotid artery morphology, it can be hypothesised that FOXD3 is involved in the pathogenesis of the craniofacial and vascular defects observed in our patient. In support of our assumption, we found in the literature another patient with a syndromic form of MA who had a deletion involving another FOX gene (FOXC1). In addition to describing the clinical history of our patient, we have reviewed all of the available literature concerning other patients with a 1p32p31 deletion, including cases from the Decipher database, and we have also reviewed the genetic disorders associated with MA, which is a useful guide for the diagnosis of syndromic form of MA. PMID:28926972

  20. Rare copy number alterations and copy-neutral loss of heterozygosity revealed in ameloblastomas by high-density whole-genome microarray analysis.

    PubMed

    Diniz, Marina Gonçalves; Duarte, Alessandra Pires; Villacis, Rolando A; Guimarães, Bruna V A; Duarte, Luiz Cláudio Pires; Rogatto, Sílvia R; Gomez, Ricardo Santiago; Gomes, Carolina Cavaliéri

    2017-05-01

    Ameloblastoma (unicystic, UA, or multicystic, MA) is a rare tumor associated with bone destruction and facial deformity. Its malignant counterpart is the ameloblastic carcinoma (AC). The BRAFV600E mutation is highly prevalent in all these tumors subtypes and cannot account for their different clinical behaviors. We assessed copy number alterations (CNAs) and copy-neutral loss of heterozygosity (cnLOH) in UA (n = 2), MA (n = 3), and AC (n = 1) using the CytoScan HD Array (Affymetrix) and the BRAFV600E status. RT-qPCR was applied in four selected genes (B4GALT1, BAG1, PKD1L2, and PPP2R5A) covered by rare alterations, also including three MA and four normal oral tissues. Fifty-seven CNAs and cnLOH were observed in the ameloblastomas and six CNAs in the AC. Seven of the CNAs were rare (six in UA and one in MA), four of them encompassing genes (gains of 7q11.21, 1q32.3, and 9p21.1 and loss of 16q23.2). We found positive correlation between rare CNA gene dosage and the expression of B4GALT1, BAG1, PKD1L2, and PPP2R5A. The AC and 1 UA were BRAF wild-type; however, this UA showed rare genomic alterations encompassing genes associated with RAF/MAPK activation. Ameloblastomas show rare CNAs and cnLOH, presenting a specific genomic profile with no overlapping of the rare alterations among UA, MA, and AC. These genomic changes might play a role in tumor evolution and in BRAFV600E-negative tumors. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Inhibition of akt phosphorylation diminishes mitochondrial biogenesis regulators, tricarboxylic acid cycle activity and exacerbates recognition memory deficit in rat model of Alzheimer's disease.

    PubMed

    Shaerzadeh, Fatemeh; Motamedi, Fereshteh; Khodagholi, Fariba

    2014-11-01

    3-Methyladenine (3-MA), as a PI3K inhibitor, is widely used for inhibition of autophagy. Inhibition of PI3K class I leads to inhibition of Akt phosphorylation, a central molecule involved in diverse arrays of intracellular cascades in nervous system. Accordingly, in the present study, we aimed to determine the alterations of specific mitochondrial biogenesis markers and mitochondrial function in 3-MA-injected rats following amyloid beta (Aβ) insult. Our data revealed that inhibition of Akt phosphorylation downregulates master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Our data also showed that decrease in PGC-1α level presumably is due to decrease in the phosphorylation of cAMP-response element binding and AMP-activated kinase, two upstream activators of PGC-1α. As a consequence, the level of some mitochondrial biogenesis factors including nuclear respiratory factor-1, mitochondrial transcription factor A, and Cytochrome c decreased significantly. Also, activities of tricarboxylic acid cycle (TCA) enzymes such as Aconitase, a-ketoglutarate dehydrogenase, and malate dehydrogenase reduced in the presence of 3-MA with or without Aβ insult. Decrease in mitochondrial biogenesis factors and TCA enzyme activity in the rats receiving 3-MA and Aβ were more compared to the rats that received either alone; indicating the additive destructive effects of these two agents. In agreement with our molecular results, data obtained from behavioral test (using novel objective recognition test) indicated that inhibition of Akt phosphorylation with or without Aβ injection impaired novel recognition (non-spatial) memory. Our results suggest that 3-MA amplified deleterious effects of Aβ by targeting central molecule Akt.

  2. A novel compensation method for the anode gain non-uniformity of multi-anode photomultiplier tubes

    NASA Astrophysics Data System (ADS)

    Lee, Chan Mi; Kwon, Sun Il; Ko, Guen Bae; Ito, Mikiko; Yoon, Hyun Suk; Lee, Dong Soo; Jong Hong, Seong; Lee, Jae Sung

    2012-01-01

    The position-sensitive multi-anode photomultiplier tube (MA-PMT) is widely used in high-resolution scintillation detectors. However, the anode gain non-uniformity of this device is a limiting factor that degrades the intrinsic performance of the detector module. The aim of this work was to develop a gain compensation method for the MA-PMT and evaluate the resulting enhancement in the performance of the detector. The method employs a circuit that is composed only of resistors and is placed between the MA-PMT and a resistive charge division network (RCN) used for position encoding. The goal of the circuit is to divide the output current from each anode, so the same current flows into the RCN regardless of the anode gain. The current division is controlled by the combination of a fixed-value series resistor with an output impedance that is much larger than the input impedance of the RCN, and a parallel resistor, which detours part of the current to ground. PSpice simulations of the compensation circuit and the RCN were performed to determine optimal values for the compensation resistors when used with Hamamatsu H8500 MA-PMTs. The intrinsic characteristics of a detector module consisting of this MA-PMT and a lutetium-gadolinium-oxyorthosilicate (LGSO) crystal array were tested with and without the gain compensation method. In simulation, the average coefficient of variation and max/min ratio decreased from 15.7% to 2.7% and 2.0 to 1.2, respectively. In the flood map of the LGSO-H8500 detector, the uniformity of the photopeak position for individual crystals and the energy resolution were much improved. The feasibility of the method was shown by applying it to an octagonal prototype positron emission tomography scanner.

  3. Seaport Protection Against chemical and Biological Attacks

    DTIC Science & Technology

    2009-06-01

    Breaux, MAJ, USA B.A., Bowling Green State University, Bowling Green, Ohio, 1991 M.A., Texas A& M , Commerce, Texas, 2001 Fort... Crichton . ―The Ships that Died of Shame.‖ Fairfax Digital (2003). http://www.smh.com.au/articles/2003/01/13/1041990234498.html (accessed June 21

  4. 12. VIEW AFT IN MAIN HOLD OF THE EVELINA M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW AFT IN MAIN HOLD OF THE EVELINA M. GOULART. OPENING IN THE BULKHEAD WAS CUT TO IMPROVE ACCESS TO ENGINE ROOM SO THAT ENGINE COULD BE REMOVED. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  5. Integrating Scientific Array Processing into Standard SQL

    NASA Astrophysics Data System (ADS)

    Misev, Dimitar; Bachhuber, Johannes; Baumann, Peter

    2014-05-01

    We live in a time that is dominated by data. Data storage is cheap and more applications than ever accrue vast amounts of data. Storing the emerging multidimensional data sets efficiently, however, and allowing them to be queried by their inherent structure, is a challenge many databases have to face today. Despite the fact that multidimensional array data is almost always linked to additional, non-array information, array databases have mostly developed separately from relational systems, resulting in a disparity between the two database categories. The current SQL standard and SQL DBMS supports arrays - and in an extension also multidimensional arrays - but does so in a very rudimentary and inefficient way. This poster demonstrates the practicality of an SQL extension for array processing, implemented in a proof-of-concept multi-faceted system that manages a federation of array and relational database systems, providing transparent, efficient and scalable access to the heterogeneous data in them.

  6. Understanding the effect of insurance expansion on utilization of inpatient surgery

    PubMed Central

    Ellimoottil, Chandy; Miller, Sarah; Ayanian, John Z.; Miller, David C.

    2014-01-01

    Importance While the enthusiasm for the Affordable Care Act (ACA) revolves around its impact on access to preventive and primary care services, the effect of this reform on surgical care remains undefined. Objective Using Massachusetts (MA) healthcare reform as a natural experiment, we estimate the differential impact of insurance expansion on the utilization of discretionary versus non-discretionary inpatient surgery. Design We used the State Inpatient Databases from MA and two control states to identify nonelderly patients (19–64 years) who underwent discretionary (DS) versus non-discretionary surgery (NDS) during the years 2003–2010. We defined DS as elective, preference-sensitive procedures (e.g., joint replacement, back surgery), and NDS as imperative and potentially lifesaving procedures (e.g., cancer surgery, hip fracture repair). Using July 2007 as the transition point between pre and post-reform periods, we performed a difference-in-differences (DID) analysis to estimate the effect of insurance expansion on rates of DS vs NDS among the entire study population, and for subgroups defined by race, income and insurance status. We then extrapolated our results from MA to the entire US population. Main Outcome(s) and Measure(s) Rate of DS and NDS performed before and after the healthcare reform in Massachusetts. Results We identified a total of 836,311 surgeries during the study period. In contrast to NDS, post-reform rates of DS increased more in MA than in control states. Based on our DID analysis, insurance expansion was associated with a 9.3% increase in the use of DS in MA (p=0.021). Conversely, the rate of NDS decreased by 4.5% (p=0.009). We found similar effects for DS in all subgroups, with the greatest increase observed for non-whites (19.9%, p<0.001). Based on the findings in MA, we estimated that full implementation of national insurance expansion would yield an additional 465,934 discretionary surgeries by 2017. Conclusions and Relevance Insurance expansion in Massachusetts was associated with increased rates of discretionary surgery, and a concurrent decrease in utilization of nondiscretionary surgery. If similar changes are seen nationally, the value of insurance expansion for surgical care may depend on the relative balance between increased expenditures and potential health benefits of greater access to elective inpatient procedures. PMID:24988945

  7. Multiyear evaluation of the durability of the resistance conferred by Ma and RMia genes to Meloidogyne incognita in Prunus under controlled conditions.

    PubMed

    Khallouk, Samira; Voisin, Roger; Portier, Ulysse; Polidori, Joël; Van Ghelder, Cyril; Esmenjaud, Daniel

    2013-08-01

    Root-knot nematodes (RKNs) (Meloidogyne spp.) are highly polyphagous pests that parasitize Prunus crops in Mediterranean climates. Breeding for RKN-resistant Prunus cultivars, as an alternative to the now-banned use of nematicides, is a real challenge, because the perennial nature of these trees increases the risk of resistance breakdown. The Ma plum resistance (R) gene, with a complete spectrum, and the RMia peach R gene, with a more restricted spectrum, both provide total control of Meloidogyne incognita, the model parthenogenetic species of the genus and the most important RKN in terms of economic losses. We investigated the durability of the resistance to this nematode conferred by these genes, comparing the results obtained with those for the tomato Mi-1 reference gene. In multiyear experiments, we applied a high and continuous nematode inoculum pressure by cultivating nematode-infested susceptible tomato plants with either Prunus accessions carrying Ma or RMia R genes, or with resistant tomato plants carrying the Mi-1 gene. Suitable conditions for Prunus development were achieved by carrying out the studies in a glasshouse, in controlled conditions allowing a short winter leaf fall and dormancy. We first assessed the plum accession 'P.2175', which is heterozygous for the Ma gene, in two successive 2-year evaluations, for resistance to two M. incognita isolates. Whatever the isolate used, no nematodes reproducing on P.2175 were detected, whereas galls and nematodes reproducing on tomato plants carrying Mi-1 were observed. In a second experiment with the most aggressive isolate, interspecific full-sib material (P.2175 × ['Garfi' almond × 'Nemared' peach]), carrying either Ma or RMia (from Nemared) or both (in the heterozygous state) or neither of these genes, was evaluated for 4 years. No virulent nematodes developed on Prunus spp. carrying R genes, whereas galling and virulent individuals were observed on Mi-1-resistant tomato plants. Thus, the resistance to M. incognita conferred by Ma in Prunus material in both a pure-plum and an interspecific genetic background, or by RMia in an interspecific background, appears to be durable, highlighting the value of these two genes for the creation of Prunus rootstock material.

  8. P-Doped NiCo2S4 nanotubes as battery-type electrodes for high-performance asymmetric supercapacitors.

    PubMed

    Lin, Jinghuang; Wang, Yiheng; Zheng, Xiaohang; Liang, Haoyan; Jia, Henan; Qi, Junlei; Cao, Jian; Tu, Jinchun; Fei, Weidong; Feng, Jicai

    2018-06-19

    NiCo2S4 is a promising electrode material for supercapacitors, due to its rich redox reactions and intrinsically high conductivity. Unfortunately, in most cases, NiCo2S4-based electrodes often suffer from low specific capacitance, low rate capability and fast capacitance fading. Herein, we have rationally designed P-doped NiCo2S4 nanotube arrays to improve the electrochemical performance through a phosphidation reaction. Characterization results demonstrate that the P element is successfully doped into NiCo2S4 nanotube arrays. Electrochemical results demonstrate that P-doped NiCo2S4 nanotube arrays exhibit better electrochemical performance than pristine NiCo2S4, e.g. higher specific capacitance (8.03 F cm-2 at 2 mA cm-2), good cycling stability (87.5% capacitance retention after 5000 cycles), and lower charge transfer resistance. More importantly, we also assemble an asymmetric supercapacitor using P-doped NiCo2S4 nanotube arrays and activated carbon on carbon cloth, which delivers a maximum energy density of 42.1 W h kg-1 at a power density of 750 W kg-1. These results demonstrate that the as-fabricated P-doped NiCo2S4 nanotube arrays on carbon cloth show great potential as a battery-type electrode for high-performance supercapacitors.

  9. 32 x 16 CMOS smart pixel array for optical interconnects

    NASA Astrophysics Data System (ADS)

    Kim, Jongwoo; Guilfoyle, Peter S.; Stone, Richard V.; Hessenbruch, John M.; Choquette, Kent D.; Kiamilev, Fouad E.

    2000-05-01

    Free space optical interconnects can increase throughput capacities and eliminate much of the energy consumption required for `all electronic' systems. High speed optical interconnects can be achieved by integrating optoelectronic devices with conventional electronics. Smart pixel arrays have been developed which use optical interconnects. An individual smart pixel cell is composed of a vertical cavity surface emitting laser (VCSEL), a photodetector, an optical receiver, a laser driver, and digital logic circuitry. Oxide-confined VCSELs are being developed to operate at 850 nm with a threshold current of approximately 1 mA. Multiple quantum well photodetectors are being fabricated from AlGaAs for use with the 850 nm VCSELs. The VCSELs and photodetectors are being integrated with complementary metal oxide semiconductor (CMOS) circuitry using flip-chip bonding. CMOS circuitry is being integrated with a 32 X 16 smart pixel array. The 512 smart pixels are serially linked. Thus, an entire data stream may be clocked through the chip and output electrically by the last pixel. Electrical testing is being performed on the CMOS smart pixel array. Using an on-chip pseudo random number generator, a digital data sequence was cycled through the chip verifying operation of the digital circuitry. Although, the prototype chip was fabricated in 1.2 micrometers technology, simulations have demonstrated that the array can operate at 1 Gb/s per pixel using 0.5 micrometers technology.

  10. Combination of short-length TiO2 nanorod arrays and compact PbS quantum-dot thin films for efficient solid-state quantum-dot-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Zhang, Zhengguo; Shi, Chengwu; Chen, Junjun; Xiao, Guannan; Li, Long

    2017-07-01

    Considering the balance of the hole diffusion length and the loading quantity of quantum-dots, the rutile TiO2 nanorod array with the length of 600 nm, the diameter of 20 nm, and the areal density of 500 μm-2 is successfully prepared by the hydrothermal method using the aqueous grown solution of 38 mM titanium isopropoxide and 6 M hydrochloric acid at 170 °C for 105 min. The compact PbS quantum-dot thin film on the TiO2 nanorod array is firstly obtained by the spin-coating-assisted successive ionic layer absorption and reaction with using 1,2-ethanedithiol (EDT). The result reveals that the strong interaction between lead and EDT is very important to control the crystallite size of PbS quantum-dots and obtain the compact PbS quantum-dot thin film on the TiO2 nanorod array. The all solid-state sensitized solar cell with the combination of the short-length, high-density TiO2 nanorod array and the compact PbS quantum-dot thin film achieves the photoelectric conversion efficiency of 4.10%, along with an open-circuit voltage of 0.52 V, a short-circuit photocurrent density of 13.56 mA cm-2 and a fill factor of 0.58.

  11. Exploring New Methods of Displaying Bit-Level Quality and Other Flags for MODIS Data

    NASA Technical Reports Server (NTRS)

    Khalsa, Siri Jodha Singh; Weaver, Ron

    2003-01-01

    The NASA Distributed Active Archive Center (DAAC) at the National Snow and Ice Data Center (NSIDC) archives and distributes snow and sea ice products derived from the MODerate resolution Imaging Spectroradiometer (MODIS) on board NASA's Terra and Aqua satellites. All MODIS standard products are in the Earth Observing System version of the Hierarchal Data Format (HDF-EOS). The MODIS science team has packed a wealth of information into each HDF-EOS file. In addition to the science data arrays containing the geophysical product, there are often pixel-level Quality Assurance arrays which are important for understanding and interpreting the science data. Currently, researchers are limited in their ability to access and decode information stored as individual bits in many of the MODIS science products. Commercial and public domain utilities give users access, in varying degrees, to the elements inside MODIS HDF-EOS files. However, when attempting to visualize the data, users are confronted with the fact that many of the elements actually represent eight different 1-bit arrays packed into a single byte array. This project addressed the need for researchers to access bit-level information inside MODIS data files. In an previous NASA-funded project (ESDIS Prototype ID 50.0) we developed a visualization tool tailored to polar gridded HDF-EOS data set. This tool,called the Polar researchers to access, geolocate, visualize, and subset data that originate from different sources and have different spatial resolutions but which are placed on a common polar grid. The bit-level visualization function developed under this project was added to PHDIS, resulting in a versatile tool that serves a variety of needs. We call this the EOS Imaging Tool.

  12. [Methamphetamine - just another stimulant or a more complex problem?].

    PubMed

    Lecomte, Tania; Massé, Marjolaine

    2014-01-01

    Methamphetamine (MA) has recently become very popular in the media, due in part to its increasing popularity as well as its psychotropic effects and the negative consequences of its use. Is it a stimulant like any other, or does methamphetamine use lead to specific difficulties in its users? The aim of this article is to provide a brief review of the literature by explaining some of the reasons for its popularity in Canada as well as the physical, dental, psychiatric, cognitive and legal problems associated with its use. MA's popularity: Regarding its popularity, MA has benefitted from multiple factors, namely its low cost for users and manufacturers, its quick and intense psychotropic effects (increased energy, sexual arousal, rapid thinking, sleeplessness, lack of appetite), its easy access, as well as its various methods of ingestion (nasal, oral, injection). MA abuse also results in a multitude of negative effects, both physical and mental. MA's physical effects: In terms of negative physical effects, cardiac problems, skin infections, sexually transmitted (and injection-related) diseases as well as meth mouth are described. MA's mental effects: In terms of mental consequences, two recently published Canadian studies revealing high rates of depression symptoms and of sustained psychotic symptoms in a subgroup of MA users are presented. Studies reporting various cognitive deficits in MA user are also reviewed, including reports of high prevalence of childhood attention deficit and hyperactivity disorder diagnoses among adult MA users. Furthermore, MA abusers are documented as having been highly exposed to trauma in their lives, with many presenting with post-traumatic stress disorder criteria. This manuscript also explores the reasons behind the forensic profiles of individuals using MA, particularly the increased tendency toward violent acts, the high incarceration rates of the homeless users and the high percentage of individuals diagnosed with antisocial personality disorder reported in studies. In terms of user profiles, various methods of ingestion, frequency of use as well as combination with other drugs are described, with a special focus on the frequent polysubstance abuse found in MA users and the reality of bingers. This manuscript describes specific treatments designed for stimulant users such as MA abusers, namely the MATRIX program, as well as modifications piloted for those with comorbid depression. Pharmacological treatments, as well as antioxidant supplements, are also discussed although they have not yielded positive results with humans to date. Overall, our goal in this manuscript is to highlight the complexity of the difficulties faced by MA users as well as the limited ability of currently available treatments to address the multiple needs associated with this complexity.

  13. Intracavitary ultrasound phased arrays for thermal therapies

    NASA Astrophysics Data System (ADS)

    Hutchinson, Erin

    Currently, the success of hyperthermia and thermal surgery treatments is limited by the technology used in the design and fabrication of clinical heating devices and the completeness of the thermometry systems used for guidance. For both hyperthermia and thermal surgery, electrically focused ultrasound generated by phased arrays provides a means of controlling localized energy deposition in body tissues. Intracavitary applicators can be used to bring the energy source close to a target volume, such as the prostate, thereby minimizing normal tissue damage. The work performed in this study was aimed at improving noninvasive prostate thermal therapies and utilized three research approaches: (1) Acoustic, thermal and optimization simulations, (2) Design and fabrication of multiple phased arrays, (3) Ex vivo and in vivo experimental testing of the heating capabilities of the phased arrays. As part of this study, a novel aperiodic phased array design was developed which resulted in a 30- 45% reduction in grating lobe levels when compared to conventional phased arrays. Measured acoustic fields generated by the constructed aperiodic arrays agreed closely with the fields predicted by the theoretical simulations and covered anatomically appropriate ranges. The power capabilities of these arrays were demonstrated to be sufficient for the purposes of hyperthermia and thermal surgery. The advantage of using phased arrays in place of fixed focus transducers was shown by demonstrating the ability of electronic scanning to increase the size of the necrosed tissue volume while providing a more uniform thermal dose, which can ultimately reduce patient treatment times. A theoretical study on the feasibility of MRI (magnetic resonance imaging) thermometry for noninvasive temperature feedback control was investigated as a means to improve transient and steady state temperature distributions achieved in hyperthermia treatments. MRI guided ex vivo and in vivo experiments demonstrated that the heating capabilities of the constructed phased arrays were adequate for hyperthermia and thermal surgery treatments. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

  14. Vortex motion and dynamical states in Josephson arrays

    NASA Astrophysics Data System (ADS)

    Trias, Enrique

    Underdamped Josephson junction arrays are used as model systems to study novel nonlinear effects. A combination of experiments, numerical simulations, and analytical analysis is used to probe different nonlinear behavior such as intrinsic localized modes, resonances in fully frustrated arrays, Meissner-like states, and vortex ratchets. Circuit models of Josephson networks are also developed, and applied to the design and measurement of parallel array oscillators. Ladder arrays have been used for an experimental study of intrinsic localized modes, or discrete breathers. Measurements of breather stability indicate that the maximum allowable bias current is proportional to the array depinning current while the minimum current is related to a junction retrapping mechanism. This retrapping instability usually leads to the formation of multi-site breathers. Collisions between the two nonlinear excitations in ladder arrays, discrete breathers and vortices, have also been numerically investigated. Discrete breathers act as pinning centers to vortex motion and the collisions can be modeled by an energy barrier activation process. When vortices are thermally induced over this barrier, a two-site breather is created. Experiments also reveal remarkable similarities among the do current-voltage characteristics of several kinds of square and triangular arrays, where two resonant voltages are observed. Simulations indicate that at full frustration a dynamical checkerboard state underlies these similarities. For such a traveling solution, the governing equations of the arrays are reduced to three coupled pendulum equations that have two characteristic resonant frequencies. Finally, a kink ratchet potential has been designed using a parallel array of Josephson junctions with alternating cell inductances and junctions areas. Experiments show that the depinning current depends on the direction of the applied current. Other properties of the depinning current versus applied field, such as a long period and a lack of reflection symmetry, have been observed and explained analytically. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139- 4307. Ph. 617-253-5668; Fax 617-253-1690.)

  15. Low threshold distributed Bragg reflector surface emitting laser diode with semiconductor air-bridge-supported top mirror

    NASA Astrophysics Data System (ADS)

    Hsin, W.; Du, G.; Gamelin, J. K.; Malloy, K. J.; Wang, S.

    1990-03-01

    A surface emitting laser diode (SELD) with two distributed Bragg reflectors (DBR) and semiconductor multilayer air-bridge-supported top mirror is fabricated. A low threshold current of 1.5 mA is achieved under room temperature CW operation. The spectrum shows a strong peak at 891 nm with a FWHM of 10 A. With light emission from the top Bragg reflector instead of from the back side of the substrate, laser arrays are easily formed with this novel structure.

  16. Enhancement and Suppression of Transmission in 3-D Nanoslits Arrays with 1- and 2-D Periodicities

    DTIC Science & Technology

    2011-01-01

    Technologies Group, 410 Jan Davis Dr., Huntsville, AL 35806 M. Scalora Charles M. Bowden Research Center AMSRD-AMR-WS-ST, RDECOM, Redstone Arsenal... Scalora , M., “Second harmonic generation from nanoslits in metal substrates: applications to palladium-based H2 sensor,” J. Nanophotonics 2, 021851 (2008...5] Vincenti, M.A., D’Orazio, A., Buncick, M., Akozbek, N., Bloemer, M.J. and Scalora , M., "Beam steering from resonant sub-wavelength slits

  17. Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

    NASA Astrophysics Data System (ADS)

    De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

    2017-07-01

    The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

  18. Nonvolatile reconfigurable sequential logic in a HfO2 resistive random access memory array.

    PubMed

    Zhou, Ya-Xiong; Li, Yi; Su, Yu-Ting; Wang, Zhuo-Rui; Shih, Ling-Yi; Chang, Ting-Chang; Chang, Kuan-Chang; Long, Shi-Bing; Sze, Simon M; Miao, Xiang-Shui

    2017-05-25

    Resistive random access memory (RRAM) based reconfigurable logic provides a temporal programmable dimension to realize Boolean logic functions and is regarded as a promising route to build non-von Neumann computing architecture. In this work, a reconfigurable operation method is proposed to perform nonvolatile sequential logic in a HfO 2 -based RRAM array. Eight kinds of Boolean logic functions can be implemented within the same hardware fabrics. During the logic computing processes, the RRAM devices in an array are flexibly configured in a bipolar or complementary structure. The validity was demonstrated by experimentally implemented NAND and XOR logic functions and a theoretically designed 1-bit full adder. With the trade-off between temporal and spatial computing complexity, our method makes better use of limited computing resources, thus provides an attractive scheme for the construction of logic-in-memory systems.

  19. Digitally programmable signal generator and method

    DOEpatents

    Priatko, G.J.; Kaskey, J.A.

    1989-11-14

    Disclosed is a digitally programmable waveform generator for generating completely arbitrary digital or analog waveforms from very low frequencies to frequencies in the gigasample per second range. A memory array with multiple parallel outputs is addressed; then the parallel output data is latched into buffer storage from which it is serially multiplexed out at a data rate many times faster than the access time of the memory array itself. While data is being multiplexed out serially, the memory array is accessed with the next required address and presents its data to the buffer storage before the serial multiplexing of the last group of data is completed, allowing this new data to then be latched into the buffer storage for smooth continuous serial data output. In a preferred implementation, a plurality of these serial data outputs are paralleled to form the input to a digital to analog converter, providing a programmable analog output. 6 figs.

  20. Digitally programmable signal generator and method

    DOEpatents

    Priatko, Gordon J.; Kaskey, Jeffrey A.

    1989-01-01

    A digitally programmable waveform generator for generating completely arbitrary digital or analog waveforms from very low frequencies to frequencies in the gigasample per second range. A memory array with multiple parallel outputs is addressed; then the parallel output data is latched into buffer storage from which it is serially multiplexed out at a data rate many times faster than the access time of the memory array itself. While data is being multiplexed out serially, the memory array is accessed with the next required address and presents its data to the buffer storage before the serial multiplexing of the last group of data is completed, allowing this new data to then be latched into the buffer storage for smooth continuous serial data output. In a preferred implementation, a plurality of these serial data outputs are paralleled to form the input to a digital to analog converter, providing a programmable analog output.

  1. Parameter optimization for transitions between memory states in small arrays of Josephson junctions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rezac, Jacob D.; Imam, Neena; Braiman, Yehuda

    Coupled arrays of Josephson junctions possess multiple stable zero voltage states. Such states can store information and consequently can be utilized for cryogenic memory applications. Basic memory operations can be implemented by sending a pulse to one of the junctions and studying transitions between the states. In order to be suitable for memory operations, such transitions between the states have to be fast and energy efficient. Here in this article we employed simulated annealing, a stochastic optimization algorithm, to study parameter optimization of array parameters which minimizes times and energies of transitions between specifically chosen states that can be utilizedmore » for memory operations (Read, Write, and Reset). Simulation results show that such transitions occur with access times on the order of 10–100 ps and access energies on the order of 10 -19–5×10 -18 J. Numerical simulations are validated with approximate analytical results.« less

  2. 76 FR 63609 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ..., 2011 at 10 a.m. ADDRESSES: The meeting will be held at the Hotel Providence, 139 Mathewson Street... Management Council, 50 Water Street, Mill 2, Newburyport, MA 01950. FOR FURTHER INFORMATION CONTACT: Paul J... possession limits. Special Accommodations This meeting is physically accessible to people with disabilities...

  3. Using Web-Based Practice to Enhance Mathematics Learning and Achievement

    ERIC Educational Resources Information Center

    Nguyen, Diem M.; Kulm, Gerald

    2005-01-01

    This article describes 1) the special features and accessibility of an innovative web-based practice instrument (WebMA) designed with randomized short-answer, matching and multiple choice items incorporated with automatically adapted feedback for middle school students; and 2) an exploratory study that compares the effects and contributions of…

  4. 77 FR 22285 - Mid-Atlantic Fishery Management Council; Public Hearings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... Alexandria, VA; Riverhead, NY; Newport News, VA; Cape May, NJ; Gloucester, MA; and Providence, RI. The Newport News hearing will also be available via webinar. For specific locations and webinar access, see... proposed actions will be available and presented at the hearings. The full Draft Environmental Impact...

  5. Ultrafine MnO2 Nanowire Arrays Grown on Carbon Fibers for High-Performance Supercapacitors

    NASA Astrophysics Data System (ADS)

    Hu, Jiyu; Qian, Feng; Song, Guosheng; Li, Wenyao; Wang, Linlin

    2016-10-01

    Large-area ultrafine MnO2 nanowire arrays (NWA) directly grew on a carbon fiber (CF, used as a substrate) by a simple electrochemical method, forming three-dimensional (3D) hierarchical heterostructures of a CF@MnO2 NWA composite. As an electrode for supercapacitors, the CF@MnO2 NWA composite exhibits excellent electrochemical performances including high specific capacitance (321.3 F g-1 at 1000 mA g-1) and good rate capability. Further, the overall capacitance retention is 99.7 % capacitance after 3000 cycles. These outstanding electrochemical performances attribute to a large number of transport channels for the penetration of electrolyte and the transportation of ions and electrons of electrodes. The as-prepared CF@MnO2 NWA composite may be a promising electrode material for high-performance supercapacitors.

  6. Self-Supported Ni(P, O)x·MoOx Nanowire Array on Nickel Foam as an Efficient and Durable Electrocatalyst for Alkaline Hydrogen Evolution.

    PubMed

    Hua, Wei; Liu, Huanyan; Wang, Jian-Gan; Wei, Bingqing

    2017-12-06

    Earth-abundant and low-cost catalysts with excellent electrocatalytic hydrogen evolution reaction (HER) activity in alkaline solution play an important role in the sustainable production of hydrogen energy. In this work, a catalyst of Ni(P, O) x ·MoO x nanowire array on nickel foam has been prepared via a facile route for efficient alkaline HER. Benefiting from the collaborative advantages of Ni(P, O) x and amorphous MoO x , as well as three-dimensional porous conductive nickel scaffold, the hybrid electrocatalyst shows high catalytic activity in 1 M KOH aqueous solution, including a small overpotential of 59 mV at 10 mA cm -2 , a low Tafel slope of 54 mV dec -1 , and excellent cycling stability.

  7. Self-Supported Ni(P, O)x·MoOx Nanowire Array on Nickel Foam as an Efficient and Durable Electrocatalyst for Alkaline Hydrogen Evolution

    PubMed Central

    Hua, Wei; Liu, Huanyan

    2017-01-01

    Earth-abundant and low-cost catalysts with excellent electrocatalytic hydrogen evolution reaction (HER) activity in alkaline solution play an important role in the sustainable production of hydrogen energy. In this work, a catalyst of Ni(P, O)x·MoOx nanowire array on nickel foam has been prepared via a facile route for efficient alkaline HER. Benefiting from the collaborative advantages of Ni(P, O)x and amorphous MoOx, as well as three-dimensional porous conductive nickel scaffold, the hybrid electrocatalyst shows high catalytic activity in 1 M KOH aqueous solution, including a small overpotential of 59 mV at 10 mA cm−2, a low Tafel slope of 54 mV dec-1, and excellent cycling stability. PMID:29210991

  8. Application of silicon zig-zag wall arrays for anodes of Li-ion batteries

    NASA Astrophysics Data System (ADS)

    Li, G. V.; Rumyantsev, A. M.; Levitskii, V. S.; Beregulin, E. V.; Zhdanov, V. V.; Terukov, E. I.; Astrova, E. V.

    2016-01-01

    Cyclic tests of anodes based on zigzag wall arrays fabricated by the electrochemical etching and post-anodization treatment of silicon have been performed. Compared with anodes based on nanowires and planar thin films, these structures have several advantages. An ex situ analysis of the morphology and structural transformations in a material subjected to cyclic lithiation was conducted by electron microscopy and micro-Raman spectroscopy. The effect of geometrical parameters and a cycling mode on the degradation rate was studied. It is shown that a significant rise in the cycle life of the anode can be obtained by the restriction of the inserted amount of lithium. The anode, subjected to galvanostatic cycling at a rate C/2.8 at a limited charge capacity of 1000 mA · h g-1, demonstrates no degradation after 1200 cycles.

  9. Multiple wavelength tunable surface-emitting laser arrays

    NASA Astrophysics Data System (ADS)

    Chang-Hasnain, Connie J.; Harbison, J. P.; Zah, Chung-En; Maeda, M. W.; Florez, L. T.; Stoffel, N. G.; Lee, Tien-Pei

    1991-06-01

    Techniques to achieve wavelength multiplexing and tuning capabilities in vertical-cavity surface-emitting lasers (VCSELs) are described, and experimental results are given. The authors obtained 140 unique, uniformly separated, single-mode wavelength emissions from a 7 x 20 VCSEL array. Large total wavelength span (about 430 A) and small wavelength separation (about 3 A) are obtained simultaneously with uncompromised laser performance. All 140 lasers have nearly the same threshold currents, voltages, and resistances. Wavelength tuning is obtained by using a three-mirror coupled-cavity configuration. The three-mirror laser is a two-terminal device and requires only one top contact. Discrete tuning with a range as large as 61 A is achieved with a small change in drive current of only 10.5 mA. The VCSEL output power variation is within 5 dB throughout the entire tuning range.

  10. Line drawing titled 'TDRS Spacecraft On-Orbit Configuration'

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Line drawing titled 'TDRS Spacecraft On-Orbit Configuration' identifies the various tracking and data relay satellite (TDRS) components (solar arrays, C-Band antenna, K-Band antenna, space ground link (SGL) antenna, single access antennas, multiple access antenna, omni antenna, solar sail). A TDRS will be deployed during the STS-26 mission. Including the space shuttle, the TDRS will be equipped to support up to 26 user spacecraft simultaneously. It will provide two types of service: 1) multiple access which can relay data from as many as 20 low data rate (100 bits per second to 50 kilobits per second) user satellites simultaneously and; 2) single access which will provide two high data rate (to 300 megabits per second) communication relays. The TDRS is three-axis stabilizrd with the body fixed antennas pointing constantly at the Earth while the solar arrays track the Sun. TDR satellites do no processing of user traffic in either direction. Rather, they operate as 'bent pipe' repeaters,

  11. The study of hard x-ray emission and electron beam generation in wire array Z-pinch and X-pinch plasmas at university-scale generators

    NASA Astrophysics Data System (ADS)

    Shrestha, Ishor Kumar

    The studies of hard x-ray (HXR) emission and electron beam generation in Z-pinch plasmas are very important for Inertial Confinement Fusion (ICF) research and HXR emission application for sources of K-shell and L-shell radiation. Energetic electron beams from Z-pinch plasmas are potentially a problem in the development of ICF. The electron beams and the accompanying HXR emission can preheat the fuel of a thermonuclear target, thereby preventing the fuel compression from reaching densities required for the ignition of a fusion reaction. The photons above 3-4 keV radiated from a Z pinch can provide detailed information about the high energy density plasmas produced at stagnation. Hence, the investigation of characteristics of hard x-rays and electron beams produced during implosions of wire array loads on university scale-generators may provide important data for future ICF, sources of K-shell and L-shell radiations and basic plasma research. This dissertation presents the results of experimental studies of HXR and electron beam generation in wire-array and X-pinch on the 1.7 MA, 100-ns current rise time Zebra generator at University of Nevada, Reno and 1-MA 100-ns current rise-time Cornell Beam Research Accelerator (COBRA) at Cornell University. The experimental study of characteristics of HXR produced by multi-planar wire arrays, compact cylindrical wire array (CCWA) and nested cylindrical wire array (NCWA) made from Al, Cu, Mo, Ag, W and Au were analyzed. The dependence of the HXR yield and power on geometry of the load, the wire material, and load mass was observed. The presence of aluminum wires in the load with the main material such as stainless steel, Cu, Mo, Ag, W or Au in combined wire array decreases HXR yield. The comparison of emission characteristics of HXR and generation of electron beams in CCWA and NCWA on both the high impedance Zebra generator and low impedance COBRA generator were investigated. Some of the "cold" K- shell spectral lines (0.7-2.3Á) and cold L-shell spectral lines (1-1.54Á) in the HXR region were observed only during the interaction of electron beam with load material and anode surface. These observations suggest that the mechanism of HXR emission should be associated with non-thermal mechanisms such as the interaction of the electron beam with the load material. In order to estimate the characteristics of the high-energetic electron beam in Z-pinch plasmas, a hard x-ray polarimeter (HXP) has been developed and used in experiments on the Zebra generator. The electron beams (energy more than 30keV) have been investigated with measurements of the polarization state of the emitted bremsstrahlung radiation from plasma. We also analyzed characteristics of energetic electron beams produced by implosions of multi-planar wire arrays, compact cylindrical and nested wire arrays as well as X-pinches. Direct indications of electron beams (electron cutoff energy EB from 42-250 keV) were obtained by using the measured current of a Faraday cup placed above the anode or mechanical damage observed in the anode surface. A comparison of total electron beam energy and the spatial and spectral analysis of the parameters of plasmas were investigated for different wire materials. The dependences of the total electron beam energy (E b) on the wire material and the geometry of the wire array load were studied.

  12. Optimization of the Hartmann-Shack microlens array

    NASA Astrophysics Data System (ADS)

    de Oliveira, Otávio Gomes; de Lima Monteiro, Davies William

    2011-04-01

    In this work we propose to optimize the microlens-array geometry for a Hartmann-Shack wavefront sensor. The optimization makes possible that regular microlens arrays with a larger number of microlenses are replaced by arrays with fewer microlenses located at optimal sampling positions, with no increase in the reconstruction error. The goal is to propose a straightforward and widely accessible numerical method to calculate an optimized microlens array for a known aberration statistics. The optimization comprises the minimization of the wavefront reconstruction error and/or the number of necessary microlenses in the array. We numerically generate, sample and reconstruct the wavefront, and use a genetic algorithm to discover the optimal array geometry. Within an ophthalmological context, as a case study, we demonstrate that an array with only 10 suitably located microlenses can be used to produce reconstruction errors as small as those of a 36-microlens regular array. The same optimization procedure can be employed for any application where the wavefront statistics is known.

  13. Highly efficient biosensors by using well-ordered ZnO/ZnS core/shell nanotube arrays

    NASA Astrophysics Data System (ADS)

    Tarish, Samar; Xu, Yang; Wang, Zhijie; Mate, Faten; Al-Haddad, Ahmed; Wang, Wenxin; Lei, Yong

    2017-10-01

    We have studied the fabrication of highly efficient glucose sensors using well-ordered heterogeneous ZnO/ZnS core/shell nanotube arrays (CSNAs). The modified electrodes exhibit a superior electrochemical response towards ferrocyanide/ferricyanide and in glucose sensing. Further, the fabricated glucose biosensor exhibited good performance over an acceptable linear range from 2.39 × 10-5 to 2.66 × 10-4 mM, with a sensitivity of 188.34 mA mM-1 cm-2, which is higher than that of the ZnO nanotube array counterpart. A low limit of detection was realized (24 μM), which is good compared with electrodes based on conventional structures. In addition, the enhanced direct electrochemistry of glucose oxidase indicates the fast electron transfer of ZnO/ZnS CSNA electrodes, with a heterogeneous electron transfer rate constant (K s) of 1.69 s-1. The fast electron transfer is attributed to the high conductivity of the modified electrodes. The presented ZnS shell can facilitate the construction of future sensors and enhance the ZnO surface in a biological environment.

  14. Nanospherical-lens lithographical Ag nanodisk arrays embedded in p-GaN for localized surface plasmon-enhanced blue light emitting diodes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wei, Tongbo, E-mail: tbwei@semi.ac.cn; Wu, Kui; Sun, Bo

    2014-06-15

    Large-scale Ag nanodisks (NDs) arrays fabricated using nanospherical-lens lithography (NLL) are embedded in p-GaN layer of an InGaN/GaN light-emitting diode (LED) for generating localized surface plasmon (LSP) coupling with the radiating dipoles in the quantum-well (QWs). Based on the Ag NDs with the controlled surface coverage, LSP leads to the improved crystalline quality of regrowth p-GaN, increased photoluminescence (PL) intensity, reduced PL decay time, and enhanced output power of LED. Compared with the LED without Ag NDs, the optical output power at a current of 350 mA of the LSP-enhanced LEDs with Ag NDs having a distance of 20 andmore » 35 nm to QWs is increased by 26.7% and 31.1%, respectively. The electrical characteristics and optical properties of LEDs with embedded Ag NPs are dependent on the distance of between Ag NPs and QWs region. The LED with Ag NDs array structure is also found to exhibit reduced emission divergence, compared to that without Ag NDs.« less

  15. Acculturation differences in communicating information about child mental health between Latino parents and primary care providers.

    PubMed

    Lê Cook, Benjamin; Brown, Jonathan D; Loder, Stephen; Wissow, Larry

    2014-12-01

    Significant Latino-white disparities in youth mental health care access and quality exist yet little is known about Latino parents' communication with providers about youth mental health and the role of acculturation in influencing this communication. We estimated regression models to assess the association between time in the US and the number of psychosocial issues discussed with the medical assistant (MA) and doctor, adjusting for child and parent mental health and sociodemographics. Other proxies of acculturation were also investigated including measures of Spanish and English language proficiency and nativity. Parent's length of time in the US was positively associated with their communication of: their child's psychosocial problems with their child's MA, stress in their own life with their child's MA, and their child's school problems with their child's doctor. These differences were especially apparent for parents living in the US for >10 years. Parent-child language discordance, parent and child nativity were also significantly associated with communication of psychosocial problems. Greater provider and MA awareness of variation in resistance to communicating psychosocial issues could improve communication, and improve the prevention, diagnosis and treatment of youth mental illness.

  16. High-Density Superconducting Cables for Advanced ACTPol

    NASA Astrophysics Data System (ADS)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Niraula, P.; Salatino, M.; Schillaci, A.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.

    2016-07-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measurement of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 \\upmu m pitch superconducting flexible cables (flex) to connect the detector wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered aluminum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97 %.

  17. High-Density Superconducting Cables for Advanced ACTPol

    NASA Technical Reports Server (NTRS)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; hide

    2016-01-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measure- ment of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 µ m pitch superconducting flexible cables (flex) to connect the detec- tor wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered alu- minum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97%.

  18. System and method for cognitive processing for data fusion

    NASA Technical Reports Server (NTRS)

    Duong, Tuan A. (Inventor); Duong, Vu A. (Inventor)

    2012-01-01

    A system and method for cognitive processing of sensor data. A processor array receiving analog sensor data and having programmable interconnects, multiplication weights, and filters provides for adaptive learning in real-time. A static random access memory contains the programmable data for the processor array and the stored data is modified to provide for adaptive learning.

  19. Loss of Visual Working Memory within Seconds: The Combined Use of Refreshable and Non-Refreshable Features

    ERIC Educational Resources Information Center

    Ricker, Timothy J.; Cowan, Nelson

    2010-01-01

    We reexamine the role of time in the loss of information from working memory, the limited information accessible for cognitive tasks. The controversial issue of whether working memory deteriorates over time was investigated using arrays of unconventional visual characters. Each array was followed by a postperceptual mask, a variable retention…

  20. Uncovering co-expression gene network modules regulating fruit acidity in diverse apples.

    PubMed

    Bai, Yang; Dougherty, Laura; Cheng, Lailiang; Zhong, Gan-Yuan; Xu, Kenong

    2015-08-16

    Acidity is a major contributor to fruit quality. Several organic acids are present in apple fruit, but malic acid is predominant and determines fruit acidity. The trait is largely controlled by the Malic acid (Ma) locus, underpinning which Ma1 that putatively encodes a vacuolar aluminum-activated malate transporter1 (ALMT1)-like protein is a strong candidate gene. We hypothesize that fruit acidity is governed by a gene network in which Ma1 is key member. The goal of this study is to identify the gene network and the potential mechanisms through which the network operates. Guided by Ma1, we analyzed the transcriptomes of mature fruit of contrasting acidity from six apple accessions of genotype Ma_ (MaMa or Mama) and four of mama using RNA-seq and identified 1301 fruit acidity associated genes, among which 18 were most significant acidity genes (MSAGs). Network inferring using weighted gene co-expression network analysis (WGCNA) revealed five co-expression gene network modules of significant (P < 0.001) correlation with malate. Of these, the Ma1 containing module (Turquoise) of 336 genes showed the highest correlation (0.79). We also identified 12 intramodular hub genes from each of the five modules and 18 enriched gene ontology (GO) terms and MapMan sub-bines, including two GO terms (GO:0015979 and GO:0009765) and two MapMap sub-bins (1.3.4 and 1.1.1.1) related to photosynthesis in module Turquoise. Using Lemon-Tree algorithms, we identified 12 regulator genes of probabilistic scores 35.5-81.0, including MDP0000525602 (a LLR receptor kinase), MDP0000319170 (an IQD2-like CaM binding protein) and MDP0000190273 (an EIN3-like transcription factor) of greater interest for being one of the 18 MSAGs or one of the 12 intramodular hub genes in Turquoise, and/or a regulator to the cluster containing Ma1. The most relevant finding of this study is the identification of the MSAGs, intramodular hub genes, enriched photosynthesis related processes, and regulator genes in a WGCNA module Turquoise that not only encompasses Ma1 but also shows the highest modular correlation with acidity. Overall, this study provides important insight into the Ma1-mediated gene network controlling acidity in mature apple fruit of diverse genetic background.

  1. Optical response from lenslike semiconductor nipple arrays

    NASA Astrophysics Data System (ADS)

    Wu, H.-M.; Lai, C.-M.; Peng, L.-H.

    2008-11-01

    The authors reported the use of recessive size reduction in self-assembled polystyrene sphere mask with anisotropic etching to form lenslike nipple arrays onto the surface of silicon and gallium nitride. These devices are shown to exhibit a filling factor near to an ideal close-packed condition and paraboloidlike etch profile with slope increased proportionally to the device aspect ratio. Specular reflectivity of less than 3% was observed over the visible spectral range for the 0.35-μm-period nipple-lens arrays. Using two-dimensional rigorous coupled-wave analysis, the latter phenomenon can be ascribed to a gradual index matching mechanism accessed by a high surface-coverage semiconductor nipple array structure.

  2. Disturbance characteristics of half-selected cells in a cross-point resistive switching memory array

    NASA Astrophysics Data System (ADS)

    Chen, Zhe; Li, Haitong; Chen, Hong-Yu; Chen, Bing; Liu, Rui; Huang, Peng; Zhang, Feifei; Jiang, Zizhen; Ye, Hongfei; Gao, Bin; Liu, Lifeng; Liu, Xiaoyan; Kang, Jinfeng; Wong, H.-S. Philip; Yu, Shimeng

    2016-05-01

    Disturbance characteristics of cross-point resistive random access memory (RRAM) arrays are comprehensively studied in this paper. An analytical model is developed to quantify the number of pulses (#Pulse) the cell can bear before disturbance occurs under various sub-switching voltage stresses based on physical understanding. An evaluation methodology is proposed to assess the disturb behavior of half-selected (HS) cells in cross-point RRAM arrays by combining the analytical model and SPICE simulation. The characteristics of cross-point RRAM arrays such as energy consumption, reliable operating cycles and total error bits are evaluated by the methodology. A possible solution to mitigate disturbance is proposed.

  3. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery.

    PubMed

    Garland, Martin J; Caffarel-Salvador, Ester; Migalska, Katarzyna; Woolfson, A David; Donnelly, Ryan F

    2012-04-10

    It has recently been proposed that the combination of skin barrier impairment using microneedles (MNs) coupled with iontophoresis (ITP) may broaden the range of drugs suitable for transdermal delivery, as well as enabling the rate of delivery to be achieved with precise electronic control. However, no reports exist on the combination of ITP with in situ drug loaded polymeric MN delivery systems. Furthermore, although a number of studies have highlighted the importance of MN design for transdermal drug delivery enhancement, to date, there has been no systematic investigation of the influence of MN geometry on the performance of polymeric MN arrays which are designed to remain in contact with the skin during the period of drug delivery. As such, for the first time, this study reports on the effect of MN heigth and MN density upon the transdermal delivery of small hydrophilic compounds (theophylline, methylene blue, and fluorescein sodium) across neonatal porcine skin in vitro, with the optimised MN array design evaluated for its potential in the electrically faciliatated delivery of peptide (bovine insulin) and protein (fluorescein isothiocyanate-labelled bovine serum albumin (FTIC-BSA)) macromolecules. The results of the in vitro drug release investigations revealed that the extent of transdermal delivery was dependent upon the design of the MN array employed, whereby an increase in MN height and an increase in MN density led to an increase in the extent of transdermal drug delivery achieved 6h after MN application. Overall, the in vitro permeation studies revealed that the MN design containing 361 MNs/cm(2) of 600 μm height resulted in the greatest extent of transdermal drug delivery. As such, this design was evaluated for its potential in the MN mediated iontophoretic transdermal delivery. Whilst the combination of MN and ITP did not further enhance the extent of small molecular weight solute delivery, the extent of peptide/protein release was significantly enhanced when ITP was used in combination of the soluble PMVE/MA MN arrays. For example, the cumulative amount of insulin permeated across neonatal porcine skin at 6h was found to be approximately 150 μg (3.25%), 227 μg (4.85%) and 462 μg (9.87%) for ITP, MN, and MN/ITP delivery strategies, respectively. Similarly, the cumulative amount of FTIC-BSA delivered across neonatal porcine skin after a 6h period was found to be approximately 110 μg (4.53%) for MN alone and 326 μg (13.40%) for MN in combination with anodal ITP (p<0.001). As such, drug loaded soluble PMVE/MA MN arrays show promise for the electrically controlled transdermal delivery of biomacromolecules in a simple, one-step approach. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. High brightness nonpolar a-plane (11-20) GaN light-emitting diodes

    NASA Astrophysics Data System (ADS)

    Jung, Sukkoo; Chang, Younghak; Bang, Kyu-Hyun; Kim, Hyung-Gu; Choi, Yoon-Ho; Hwang, Sung-Min; Baik, Kwang Hyeon

    2012-02-01

    We report on high brightness nonpolar a-plane InGaN/GaN LEDs using patterned lateral overgrowth (PLOG) epitaxy. High crystal-quality and smooth surfaces for a-plane GaN (a-GaN) films were achieved using PLOG with an array of hexagonal SiO2 patterns. The XRC FWHMs of as-grown PLOG a-GaN films were found to be 414 and 317 arcsec (450 and 455 arcsec for planar a-GaN films) along the c-axis and m-axis directions, respectively. Plan-view CL clearly reveals the periodic hexagonal patterns with higher band edge emission intensity, implying that the luminescence properties of a-GaN films lying above the SiO2 mask are improved. The light output powers of a-InGaN/GaN PLOG LEDs were measured to be 7.5 mW and 20 mW at drive currents of 20 mA and 100 mA, respectively. A negligible blue-shift was observed in the peak emission wavelength with increasing drive current up to 100 mA, indicating that there are no strong internal fields in nonpolar a-InGaN/GaN LEDs. We believe that nonpolar a-plane InGaN/GaN LEDs hold promise for efficient nitride emitters if the growth conditions are further optimized.

  5. Arcing in LEO: Does the Whole Array Discharge?

    NASA Technical Reports Server (NTRS)

    Ferguson, Dale C.; Vayner, Boris V.; Galofaro, Joel T.; Hillard, G. Barry

    2005-01-01

    The conventional wisdom about solar array arcing in LEO is that only the parts of the solar array that are swept over by the arc-generated plasma front are discharged in the initial arc. This limits the amount of energy that can be discharged. Recent work done at the NASA Glenn Research Center has shown that this idea is mistaken. In fact, the capacitance of the entire solar array may be discharged, which for large arrays leads to very large and possibly debilitating arcs, even if no sustained arc occurs. We present the laboratory work that conclusively demonstrates this fact by using a grounded plate that prevents the arc-plasma front from reaching certain array strings. Finally, we discuss the dependence of arc strength and arc pulse width on the capacitance that is discharged, and provide a physical mechanism for discharge of the entire array, even when parts of the array are not accessible to the arc-plasma front. Mitigation techniques are also presented.

  6. Biographical sketch: Albert P. Iskrant, MA, FAPHA.

    PubMed

    Brand, Richard A

    2010-07-01

    This biographical sketch on Albert P. Iskrant corresponds to the historic text, The Classic: The Etiology of Fractured Hips in Females, available at DOI 10.1007/s11999-010-1267-y . The article can also be accessed on the American Journal of Public Health web site at http://ajph.aphapublications.org/cgi/reprint/58/3/485 .

  7. 76 FR 67196 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the University...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... disabilities to increase their independence, productivity, and inclusion through access to post-secondary..., Institute for Community Inclusion in Boston, MA, To Support the Think College Project AGENCY: Administration on Developmental Disabilities, ACF, HHS. ACTION: Notice announcing the award of a single-source...

  8. Earliest Archaeological Evidence of Persistent Hominin Carnivory

    PubMed Central

    Ferraro, Joseph V.; Plummer, Thomas W.; Pobiner, Briana L.; Oliver, James S.; Bishop, Laura C.; Braun, David R.; Ditchfield, Peter W.; Seaman, John W.; Binetti, Katie M.; Seaman, John W.; Hertel, Fritz; Potts, Richard

    2013-01-01

    The emergence of lithic technology by ∼2.6 million years ago (Ma) is often interpreted as a correlate of increasingly recurrent hominin acquisition and consumption of animal remains. Associated faunal evidence, however, is poorly preserved prior to ∼1.8 Ma, limiting our understanding of early archaeological (Oldowan) hominin carnivory. Here, we detail three large well-preserved zooarchaeological assemblages from Kanjera South, Kenya. The assemblages date to ∼2.0 Ma, pre-dating all previously published archaeofaunas of appreciable size. At Kanjera, there is clear evidence that Oldowan hominins acquired and processed numerous, relatively complete, small ungulate carcasses. Moreover, they had at least occasional access to the fleshed remains of larger, wildebeest-sized animals. The overall record of hominin activities is consistent through the stratified sequence – spanning hundreds to thousands of years – and provides the earliest archaeological evidence of sustained hominin involvement with fleshed animal remains (i.e., persistent carnivory), a foraging adaptation central to many models of hominin evolution. PMID:23637995

  9. Reactivity of main components and substituent distribution in esterified sugarcane bagasse prepared by effective solid phase reaction.

    PubMed

    Gan, Tao; Zhang, Yanjuan; Chen, Yane; Hu, Huayu; Yang, Mei; Huang, Zuqiang; Chen, Dong; Huang, Aimin

    2018-02-01

    Three main components of lignocellulose (cellulose, hemicellulose, and lignin isolated from sugarcane bagasse (SCB)) as well as holocellulose and SCB were modified with maleic acid by mechanical activation (MA)-assisted solid phase reaction (MASPR) technology. The order of reactivity was found to be lignin>hemicellulose>cellulose. The amorphous structure of lignin and hemicellulose mainly attributed to their better reactivity, and the modified lignin could reach a maximum degree of esterification (DE) of 93.45%. MA improved the accessibility and reactivity of cellulose, as the DE of modified cellulose gradually increased with milling time and reached the maximum value of 57.30% at 120min, which had significant effect on structure changes and DE of modified holocellulose and SCB. MA enhanced the esterification of all three components in lignocellulose with relatively high substituent distribution in them, and maleated SCB with a maximum DE of 64.17% was successfully prepared by this simple, green, and effective MASPR technology. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Evident Enhancement of Photoelectrochemical Hydrogen Production by Electroless Deposition of M-B (M = Ni, Co) Catalysts on Silicon Nanowire Arrays.

    PubMed

    Yang, Yong; Wang, Mei; Zhang, Peili; Wang, Weihan; Han, Hongxian; Sun, Licheng

    2016-11-09

    Modification of p-type Si surface by active and stable earth-abundant electrocatalysts is an effective strategy to improve the sluggish kinetics for the hydrogen evolution reaction (HER) at p-Si/electrolyte interface and to develop highly efficient and low-cost photocathodes for hydrogen production from water. To this end, Si nanowire (Si-NW) array has been loaded with highly efficient electrocatalysts, M-B (M = Ni, Co), by facile and quick electroless plating to build M-B catalyst-modified Si nanowire-array-textured photocathodes for water reduction to H 2 . Compared with the bare Si-NW array, composite Si-NWs/M-B arrays display evidently enhanced photoelectrochemical (PEC) performance. The onset potential (V phon ) of cathodic photocurrent is positively shifted by 530-540 mV to 0.44-0.45 V vs RHE, and the short-circuit current density (J sc ) is up to 19.5 mA cm -2 in neutral buffer solution under simulated 1 sun illumination. Impressively, the half-cell photopower conversion efficiencies (η hc ) of the optimized Si-NWs/Co-B (2.53%) and Si-NWs/Ni-B (2.45%) are comparable to that of Si-NWs/Pt (2.46%). In terms of the large J sc , V phon , and η hc values, as well as the high Faradaic efficiency, Si-NWs/M-B electrodes are among the top performing Si photocathodes which are modified with HER electrocatalysts but have no buried solid/solid junction.

  11. The Ocean Observatories Initiative: Unprecedented access to real-time data streaming from the Cabled Array through OOI Cyberinfrastructure

    NASA Astrophysics Data System (ADS)

    Knuth, F.; Vardaro, M.; Belabbassi, L.; Smith, M. J.; Garzio, L. M.; Crowley, M. F.; Kerfoot, J.; Kawka, O. E.

    2016-02-01

    The National Science Foundation's Ocean Observatories Initiative (OOI), is a broad-scale, multidisciplinary facility that will transform oceanographic research by providing users with unprecedented access to long-term datasets from a variety of deployed physical, chemical, biological, and geological sensors. The Cabled Array component of the OOI, installed and operated by the University of Washington, is located on the Juan de Fuca tectonic plate off the coast of Oregon. It is a unique network of >100 cabled instruments and instrumented moorings transmitting data to shore in real-time via fiber optic technology. Instruments now installed include HD video and digital still cameras, mass spectrometers, a resistivity-temperature probe inside the orifice of a high-temperature hydrothermal vent, upward-looking ADCP's, pH and pC02 sensors, Horizontal Electrometer Pressure Inverted Echosounders and many others. Here, we present the technical aspects of data streaming from the Cabled Array through the OOI Cyberinfrastructure. We illustrate the types of instruments and data products available, data volume and density, processing levels and algorithms used, data delivery methods, file formats and access methods through the graphical user interface. Our goal is to facilitate the use and access to these unprecedented, co-registered oceanographic datasets. We encourage researchers to collaborate through the use of these simultaneous, interdisciplinary measurements, in the exploration of short-lived events (tectonic, volcanic, biological, severe storms), as well as long-term trends in ocean systems (circulation patterns, climate change, ocean acidity, ecosystem shifts).

  12. 78 FR 5797 - Missisquoi Associates; Notice of Application for Amendment of License and Soliciting Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... to allow its affiliate, EGP Solar 1, LLC, to construct and maintain a 2.2 megawatt solar photovoltaic... solar array would be constructed on both sides of Heather Lane (the project's access road), but public... be used for the solar array is currently devoid of trees, although some grading and tree cutting is...

  13. Quantum Simulation of Spin Models on an Arbitrary Lattice with Trapped Ions (Open Access, Publisher’s Version)

    DTIC Science & Technology

    2012-09-27

    onto a 2D array of N 2 micromirrors [33] that are each individually phase modulated at a single frequency (and phase) [34] and are finally focused on...beams that strike an N × N array of micromirrors each independently modulated, or a spatial light modulator. overhead to the design and fabrication of

  14. WebArray: an online platform for microarray data analysis

    PubMed Central

    Xia, Xiaoqin; McClelland, Michael; Wang, Yipeng

    2005-01-01

    Background Many cutting-edge microarray analysis tools and algorithms, including commonly used limma and affy packages in Bioconductor, need sophisticated knowledge of mathematics, statistics and computer skills for implementation. Commercially available software can provide a user-friendly interface at considerable cost. To facilitate the use of these tools for microarray data analysis on an open platform we developed an online microarray data analysis platform, WebArray, for bench biologists to utilize these tools to explore data from single/dual color microarray experiments. Results The currently implemented functions were based on limma and affy package from Bioconductor, the spacings LOESS histogram (SPLOSH) method, PCA-assisted normalization method and genome mapping method. WebArray incorporates these packages and provides a user-friendly interface for accessing a wide range of key functions of limma and others, such as spot quality weight, background correction, graphical plotting, normalization, linear modeling, empirical bayes statistical analysis, false discovery rate (FDR) estimation, chromosomal mapping for genome comparison. Conclusion WebArray offers a convenient platform for bench biologists to access several cutting-edge microarray data analysis tools. The website is freely available at . It runs on a Linux server with Apache and MySQL. PMID:16371165

  15. High-performance lithium-ion battery and symmetric supercapacitors based on FeCo₂O₄ nanoflakes electrodes.

    PubMed

    Mohamed, Saad Gomaa; Chen, Chih-Jung; Chen, Chih Kai; Hu, Shu-Fen; Liu, Ru-Shi

    2014-12-24

    A successive preparation of FeCo2O4 nanoflakes arrays on nickel foam substrates is achieved by a simple hydrothermal synthesis method. After 170 cycles, a high capacity of 905 mAh g(-1) at 200 mA g(-1) current density and very good rate capabilities are obtained for lithium-ion battery because of the 2D porous structures of the nanoflakes arrays. The distinctive structural features provide the battery with excellent electrochemical performance. The symmetric supercapacitor on nonaqueous electrolyte demonstrates high specific capacitance of 433 F g(-1) at 0.1 A g(-1) and 16.7 F g(-1) at high scan rate of 5 V s(-1) and excellent cyclic performance of 2500 cycles of charge-discharge cycling at 2 A g(-1) current density, revealing excellent long-term cyclability of the electrode even under rapid charge-discharge conditions.

  16. X-ray absorption spectroscopy of aluminum z-pinch plasma with tungsten backlighter planar wire array source.

    PubMed

    Osborne, G C; Kantsyrev, V L; Safronova, A S; Esaulov, A A; Weller, M E; Shrestha, I; Shlyaptseva, V V; Ouart, N D

    2012-10-01

    Absorption features from K-shell aluminum z-pinch plasmas have recently been studied on Zebra, the 1.7 MA pulse power generator at the Nevada Terawatt Facility. In particular, tungsten plasma has been used as a semi-backlighter source in the generation of aluminum K-shell absorption spectra by placing a single Al wire at or near the end of a single planar W array. All spectroscopic experimental results were recorded using a time-integrated, spatially resolved convex potassium hydrogen phthalate (KAP) crystal spectrometer. Other diagnostics used to study these plasmas included x-ray detectors, optical imaging, laser shadowgraphy, and time-gated and time-integrated x-ray pinhole imagers. Through comparisons with previous publications, Al K-shell absorption lines are shown to be from much lower electron temperature (∼10-40 eV) plasmas than emission spectra (∼350-500 eV).

  17. Three-dimensional cotton-like nickel nanowire@Ni-Co hydroxide nanosheet arrays as binder-free electrode for high-performance asymmetric supercapacitor

    NASA Astrophysics Data System (ADS)

    Wan, Houzhao; Li, Lang; Xu, Yang; Tan, Qiuyang; Liu, Xiang; Zhang, Jun; Wang, Hanbin; Wang, Hao

    2018-05-01

    Three-dimensional (3D) cotton-like Ni-Co layered double hydroxide nanosheet arrays/nickel nanowires (3D Ni-Co LDH/NiNw) were successfully fabricated through a facile chemical bath deposition method. The 3D nickel nanowires are used as a conductive substrate with robust adhesion for high-pseudocapacitance Ni-Co LDH. The 3D Ni-Co LDH/NiNw electrode shows a high areal specific capacitance of 14 F cm-2 at 5 mA cm-2 and quality specific capacitance of 466.6 F g-1 at 0.125 A g-1 with respect to the whole quality of the electrode. The fabricated asymmetric supercapacitor exhibits a remarkable energy density of 0.387 mWh cm-2 using Ni-Co LDH/NiNw as the negative electrode. This high-performance composite electrode presents a new and affordable general approach for supercapacitors.

  18. Determination of plasma pinch time and effective current radius of double planar wire array implosions from current measurements on a 1-MA linear transformer driver

    NASA Astrophysics Data System (ADS)

    Steiner, Adam M.; Yager-Elorriaga, David A.; Patel, Sonal G.; Jordan, Nicholas M.; Gilgenbach, Ronald M.; Safronova, Alla S.; Kantsyrev, Victor L.; Shlyaptseva, Veronica V.; Shrestha, Ishor; Schmidt-Petersen, Maximillian T.

    2016-10-01

    Implosions of planar wire arrays were performed on the Michigan Accelerator for Inductive Z-pinch Experiments, a linear transformer driver (LTD) at the University of Michigan. These experiments were characterized by lower than expected peak currents and significantly longer risetimes compared to studies performed on higher impedance machines. A circuit analysis showed that the load inductance has a significant impact on the current output due to the comparatively low impedance of the driver; the long risetimes were also attributed to high variability in LTD switch closing times. A circuit model accounting for these effects was employed to measure changes in load inductance as a function of time to determine plasma pinch timing and calculate a minimum effective current-carrying radius. These calculations showed good agreement with available shadowgraphy and x-ray diode measurements.

  19. Electron temperature diagnostics of aluminium plasma in a z-pinch experiment at the “QiangGuang-1" facility

    NASA Astrophysics Data System (ADS)

    Li, Mo; Wu, Jian; Wang, Liang-Ping; Wu, Gang; Han, Juan-Juan; Guo, Ning; Qiu, Meng-Tong

    2012-12-01

    Two curved crystal spectrometers are set up on the “QiangGuang-1" generator to measure the z-pinch plasma spectra emitted from planar aluminum wire array loads. Kodak Biomax-MS film and an IRD AXUVHS5# array are employed to record time-integrated and time-resolved free-bound radiation, respectively. The photon energy recorded by each detector is ascertained by using the L-shell lines of molybdenum plasma. Based on the exponential relation between the continuum power and photon energies, the aluminum plasma electron temperatures are measured. For the time-integrated diagnosis, several “bright spots" indicate electron temperatures between (450 eV ~ 520 eV) ± 35%. And for the time-resolved ones, the result shows that the electron temperature reaches about 800 eV ± 30% at peak power. The system satisfies the demand of z-pinch plasma electron temperature diagnosis on a ~ 1 MA facility.

  20. Improvement of the electrochemical properties via poly(3,4-ethylenedioxythiophene) oriented micro/nanorods

    NASA Astrophysics Data System (ADS)

    Li, Yu; Wang, Bichen; Chen, Huimin; Feng, Wei

    Arrays of oriented poly(3,4-ethylenedioxythiophene) (PEDOT) micro/nanorods are synthesized by electrochemical galvanostatic method at the current density of 1 mA cm -2 in the cetyltrimethylammonium bromide (CTAB) aqueous solution whose pH value is 1. The CTAB is used both as the surfactant and the supporting salt in the electrolyte solution. The electrochemical properties of PEDOT films are characterized by cyclic voltammetry and galvanostatic charge/discharge techniques, which indicate that the arrays of oriented PEDOT micro/nanorods can be applied as the electrode materials of supercapacitors. In addition, the cycling performance of PEDOT micro/nanorods is much better than that of traditional PEDOT particles. The effects of the concentration of CTAB, the current density, and pH value of electrolyte solutions on the morphologies and electrochemical properties of PEDOT films are investigated. The mechanism of different morphologies formation is discussed in this study as well.

  1. Indications of Intermediate-scale Anisotropy of Cosmic Rays with Energy Greater Than 57 EeV in the Northern Sky Measured with the Surface Detector of the Telescope Array Experiment

    NASA Astrophysics Data System (ADS)

    Abbasi, R. U.; Abe, M.; Abu-Zayyad, T.; Allen, M.; Anderson, R.; Azuma, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Chae, M. J.; Cheon, B. G.; Chiba, J.; Chikawa, M.; Cho, W. R.; Fujii, T.; Fukushima, M.; Goto, T.; Hanlon, W.; Hayashi, Y.; Hayashida, N.; Hibino, K.; Honda, K.; Ikeda, D.; Inoue, N.; Ishii, T.; Ishimori, R.; Ito, H.; Ivanov, D.; Jui, C. C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O.; Kasahara, K.; Kawai, H.; Kawakami, S.; Kawana, S.; Kawata, K.; Kido, E.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Kitamura, S.; Kitamura, Y.; Kuzmin, V.; Kwon, Y. J.; Lan, J.; Lim, S. I.; Lundquist, J. P.; Machida, K.; Martens, K.; Matsuda, T.; Matsuyama, T.; Matthews, J. N.; Minamino, M.; Mukai, K.; Myers, I.; Nagasawa, K.; Nagataki, S.; Nakamura, T.; Nonaka, T.; Nozato, A.; Ogio, S.; Ogura, J.; Ohnishi, M.; Ohoka, H.; Oki, K.; Okuda, T.; Ono, M.; Oshima, A.; Ozawa, S.; Park, I. H.; Pshirkov, M. S.; Rodriguez, D. C.; Rubtsov, G.; Ryu, D.; Sagawa, H.; Sakurai, N.; Sampson, A. L.; Scott, L. M.; Shah, P. D.; Shibata, F.; Shibata, T.; Shimodaira, H.; Shin, B. K.; Smith, J. D.; Sokolsky, P.; Springer, R. W.; Stokes, B. T.; Stratton, S. R.; Stroman, T. A.; Suzawa, T.; Takamura, M.; Takeda, M.; Takeishi, R.; Taketa, A.; Takita, M.; Tameda, Y.; Tanaka, H.; Tanaka, K.; Tanaka, M.; Thomas, S. B.; Thomson, G. B.; Tinyakov, P.; Tkachev, I.; Tokuno, H.; Tomida, T.; Troitsky, S.; Tsunesada, Y.; Tsutsumi, K.; Uchihori, Y.; Udo, S.; Urban, F.; Vasiloff, G.; Wong, T.; Yamane, R.; Yamaoka, H.; Yamazaki, K.; Yang, J.; Yashiro, K.; Yoneda, Y.; Yoshida, S.; Yoshii, H.; Zollinger, R.; Zundel, Z.

    2014-08-01

    We have searched for intermediate-scale anisotropy in the arrival directions of ultrahigh-energy cosmic rays with energies above 57 EeV in the northern sky using data collected over a 5 yr period by the surface detector of the Telescope Array experiment. We report on a cluster of events that we call the hotspot, found by oversampling using 20° radius circles. The hotspot has a Li-Ma statistical significance of 5.1σ, and is centered at R.A. = 146.°7, decl. = 43.°2. The position of the hotspot is about 19° off of the supergalactic plane. The probability of a cluster of events of 5.1σ significance, appearing by chance in an isotropic cosmic-ray sky, is estimated to be 3.7 × 10-4 (3.4σ).

  2. Production of atmospheric-pressure glow discharge in nitrogen using needle-array electrode

    NASA Astrophysics Data System (ADS)

    Takaki, K.; Hosokawa, M.; Sasaki, T.; Mukaigawa, S.; Fujiwara, T.

    2005-04-01

    An atmospheric pressure glow discharge was generated using a needle-array electrode in nitrogen, and the voltage-current characteristics of the glow discharge were obtained in a range from 1 mA to 60 A. A pulsed high voltage with short rise time under 10 ns was employed to generate streamer discharges simultaneously at all needle tips. The large number of streamer discharges prevented the glow-to-arc transition caused by inhomogeneous thermalization. Semiconductor opening switch diodes were employed as an opening switch to shorten the rise time. The glow voltage was almost constant until the discharge current became 0.3 A, whereas the voltage increased with the current higher than 0.3 A. Electron density and temperature in a positive column of the glow discharge at 60 A were obtained to 1.4×1012cm-3 and 1.3 eV from calculation based on nitrogen swarm data.

  3. Three-dimensional cotton-like nickel nanowire@Ni-Co hydroxide nanosheet arrays as binder-free electrode for high-performance asymmetric supercapacitor.

    PubMed

    Wan, Houzhao; Li, Lang; Xu, Yang; Tan, Qiuyang; Liu, Xiang; Zhang, Jun; Wang, Hanbin; Wang, Hao

    2018-05-11

    Three-dimensional (3D) cotton-like Ni-Co layered double hydroxide nanosheet arrays/nickel nanowires (3D Ni-Co LDH/NiNw) were successfully fabricated through a facile chemical bath deposition method. The 3D nickel nanowires are used as a conductive substrate with robust adhesion for high-pseudocapacitance Ni-Co LDH. The 3D Ni-Co LDH/NiNw electrode shows a high areal specific capacitance of 14 F cm -2 at 5 mA cm -2 and quality specific capacitance of 466.6 F g -1 at 0.125 A g -1 with respect to the whole quality of the electrode. The fabricated asymmetric supercapacitor exhibits a remarkable energy density of 0.387 mWh cm -2 using Ni-Co LDH/NiNw as the negative electrode. This high-performance composite electrode presents a new and affordable general approach for supercapacitors.

  4. A phylogenetic analysis of the grape genus (Vitis L.) reveals broad reticulation and concurrent diversification during neogene and quaternary climate change

    PubMed Central

    2013-01-01

    Background Grapes are one of the most economically important fruit crops. There are about 60 species in the genus Vitis. The phylogenetic relationships among these species are of keen interest for the conservation and use of this germplasm. We selected 309 accessions from 48 Vitis species,varieties, and outgroups, examined ~11 kb (~3.4 Mb total) of aligned nuclear DNA sequences from 27 unlinked genes in a phylogenetic context, and estimated divergence times based on fossil calibrations. Results Vitis formed a strongly supported clade. There was substantial support for species and less for the higher-level groupings (series). As estimated from extant taxa, the crown age of Vitis was 28 Ma and the divergence of subgenera (Vitis and Muscadinia) occurred at ~18 Ma. Higher clades in subgenus Vitis diverged 16 – 5 Ma with overlapping confidence intervals, and ongoing divergence formed extant species at 12 – 1.3 Ma. Several species had species-specific SNPs. NeighborNet analysis showed extensive reticulation at the core of subgenus Vitis representing the deeper nodes, with extensive reticulation radiating outward. Fitch Parsimony identified North America as the origin of the most recent common ancestor of extant Vitis species. Conclusions Phylogenetic patterns suggested origination of the genus in North America, fragmentation of an ancestral range during the Miocene, formation of extant species in the late Miocene-Pleistocene, and differentiation of species in the context of Pliocene-Quaternary tectonic and climatic change. Nuclear SNPs effectively resolved relationships at and below the species level in grapes and rectified several misclassifications of accessions in the repositories. Our results challenge current higher-level classifications, reveal the abundance of genetic diversity in the genus that is potentially available for crop improvement, and provide a valuable resource for species delineation, germplasm conservation and use. PMID:23826735

  5. A 34K SNP genotyping array for Populus trichocarpa: design, application to the study of natural populations and transferability to other Populus species

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Geraldes, Armando; Hannemann, Jan; Grassa, Chris

    2013-01-01

    Genetic mapping of quantitative traits requires genotypic data for large numbers of markers in many individuals. Despite the declining costs of genotyping by sequencing, for most studies, the use of large SNP genotyping arrays still offers the most cost-effective solution for large-scale targeted genotyping. Here we report on the design and performance of a SNP genotyping array for Populus trichocarpa (black cottonwood). This genotyping array was designed with SNPs pre-ascertained in 34 wild accessions covering most of the species range. Due to the rapid decay of linkage disequilibrium in P. trichocarpa we adopted a candidate gene approach to the arraymore » design that resulted in the selection of 34,131 SNPs, the majority of which are located in, or within 2 kb, of 3,543 candidate genes. A subset of the SNPs (539) was selected based on patterns of variation among the SNP discovery accessions. We show that more than 95% of the loci produce high quality genotypes and that the genotyping error rate for these is likely below 2%, indicating that high-quality data are generated with this array. We demonstrate that even among small numbers of samples (n=10) from local populations over 84% of loci are polymorphic. We also tested the applicability of the array to other species in the genus and found that due to ascertainment bias the number of polymorphic loci decreases rapidly with genetic distance, with the largest numbers detected in other species in section Tacamahaca (P. balsamifera and P. angustifolia). Finally, we provide evidence for the utility of the array for intraspecific studies of genetic differentiation and for species assignment and the detection of natural hybrids.« less

  6. Self-assembled ordered carbon-nanotube arrays and membranes.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Overmyer, Donald L.; Siegal, Michael P.; Yelton, William Graham

    2004-11-01

    Imagine free-standing flexible membranes with highly-aligned arrays of carbon nanotubes (CNTs) running through their thickness. Perhaps with both ends of the CNTs open for highly controlled nanofiltration? Or CNTs at heights uniformly above a polymer membrane for a flexible array of nanoelectrodes or field-emitters? How about CNT films with incredible amounts of accessible surface area for analyte adsorption? These self-assembled crystalline nanotubes consist of multiple layers of graphene sheets rolled into concentric cylinders. Tube diameters (3-300 nm), inner-bore diameters (2-15 nm), and lengths (nanometers - microns) are controlled to tailor physical, mechanical, and chemical properties. We proposed to explore growthmore » and characterize nanotube arrays to help determine their exciting functionality for Sandia applications. Thermal chemical vapor deposition growth in a furnace nucleates from a metal catalyst. Ordered arrays grow using templates from self-assembled hexagonal arrays of nanopores in anodized-aluminum oxide. Polymeric-binders can mechanically hold the CNTs in place for polishing, lift-off, and membrane formation. The stiffness, electrical and thermal conductivities of CNTs make them ideally suited for a wide-variety of possible applications. Large-area, highly-accessible gas-adsorbing carbon surfaces, superb cold-cathode field-emission, and unique nanoscale geometries can lead to advanced microsensors using analyte adsorption, arrays of functionalized nanoelectrodes for enhanced electrochemical detection of biological/explosive compounds, or mass-ionizers for gas-phase detection. Materials studies involving membrane formation may lead to exciting breakthroughs in nanofiltration/nanochromatography for the separation of chemical and biological agents. With controlled nanofilter sizes, ultrafiltration will be viable to separate and preconcentrate viruses and many strains of bacteria for 'down-stream' analysis.« less

  7. Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal.

    PubMed

    Shomaker, Lauren B; Tanofsky-Kraff, Marian; Zocca, Jaclyn M; Courville, Amber; Kozlosky, Merel; Columbo, Kelli M; Wolkoff, Laura E; Brady, Sheila M; Crocker, Melissa K; Ali, Asem H; Yanovski, Susan Z; Yanovski, Jack A

    2010-10-01

    Eating in the absence of hunger (EAH) is typically assessed by measuring youths' intake of palatable snack foods after a standard meal designed to reduce hunger. Because energy intake required to reach satiety varies among individuals, a standard meal may not ensure the absence of hunger among participants of all weight strata. The objective of this study was to compare adolescents' EAH observed after access to a very large food array with EAH observed after a standardized meal. Seventy-eight adolescents participated in a randomized crossover study during which EAH was measured as intake of palatable snacks after ad libitum access to a very large array of lunch-type foods (>10,000 kcal) and after a lunch meal standardized to provide 50% of the daily estimated energy requirements. The adolescents consumed more energy and reported less hunger after the large-array meal than after the standardized meal (P values < 0.001). They consumed ≈70 kcal less EAH after the large-array meal than after the standardized meal (295 ± 18 compared with 365 ± 20 kcal; P < 0.001), but EAH intakes after the large-array meal and after the standardized meal were positively correlated (P values < 0.001). The body mass index z score and overweight were positively associated with EAH in both paradigms after age, sex, race, pubertal stage, and meal intake were controlled for (P values ≤ 0.05). EAH is observable and positively related to body weight regardless of whether youth eat in the absence of hunger from a very large-array meal or from a standardized meal. This trial was registered at clinicaltrials.gov as NCT00631644.

  8. An Improved Zero Potential Circuit for Readout of a Two-Dimensional Resistive Sensor Array.

    PubMed

    Wu, Jian-Feng; Wang, Feng; Wang, Qi; Li, Jian-Qing; Song, Ai-Guo

    2016-12-06

    With one operational amplifier (op-amp) in negative feedback, the traditional zero potential circuit could access one element in the two-dimensional (2-D) resistive sensor array with the shared row-column fashion but it suffered from the crosstalk problem for the non-scanned elements' bypass currents, which were injected into array's non-scanned electrodes from zero potential. Firstly, for suppressing the crosstalk problem, we designed a novel improved zero potential circuit with one more op-amp in negative feedback to sample the total bypass current and calculate the precision resistance of the element being tested (EBT) with it. The improved setting non-scanned-electrode zero potential circuit (S-NSE-ZPC) was given as an example for analyzing and verifying the performance of the improved zero potential circuit. Secondly, in the S-NSE-ZPC and the improved S-NSE-ZPC, the effects of different parameters of the resistive sensor arrays and their readout circuits on the EBT's measurement accuracy were simulated with the NI Multisim 12. Thirdly, part features of the improved circuit were verified with the experiments of a prototype circuit. Followed, the results were discussed and the conclusions were given. The experiment results show that the improved circuit, though it requires one more op-amp, one more resistor and one more sampling channel, can access the EBT in the 2-D resistive sensor array more accurately.

  9. Vector magnetic field observations with the Haleakala polarimeter

    NASA Technical Reports Server (NTRS)

    Mickey, D. L.

    1985-01-01

    Several enhancements were recently made to the Haleakala polarimeter. Linear array detectors provide simultaneous resolution over a 3-A wavelength range, with spectral resolution of 40 mA. Optical fibers are now used to carry the intensity-modulated light from the rotating quarter-wave plate polarimeter to the echelle spectrometer, permitting its removal from the spar to a more stable environment. These changes, together with improved quarter-wave plates, reduced systematic errors to a few parts in 10,000 for routine observations. Examples of Stokes profiles and derived magnetic field maps are presented.

  10. In situ growth of well-ordered NiFe-MOF-74 on Ni foam by Fe2+ induction as an efficient and stable electrocatalyst for water oxidation.

    PubMed

    Xing, Jiale; Guo, Kailu; Zou, Zehua; Cai, Minmin; Du, Jing; Xu, Cailing

    2018-06-06

    Well-ordered NiFe-MOF-74 is in situ grown on Ni foam by the induction of Fe2+ and directly used as an OER electrocatalyst. Benefited from the intrinsic open porous structure of MOF-74, the in situ formed MOF arrays and the synergistic effect of Ni and Fe, outstanding water oxidation activity is obtained in alkaline electrolytes with an overpotential of 223 mV at 10 mA cm-2.

  11. Study of the time-resolved, 3-dimensional current density distribution in solid metallic liners at 1 MA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bott-Suzuki, S. C.; Cordaro, S. W.; Caballero Bendixsen, L. S.

    We present a study of the time varying current density distribution in solid metallic liner experiments at the 1MA level. Measurements are taken using an array of magnetic field probes which provide 2D triangulation of the average centroid of the drive current in the load at 3 discrete axial positions. These data are correlated with gated optical self-emission imaging which directly images the breakdown and plasma formation region. Results show that the current density is azimuthally non-uniform, and changes significantly throughout the 100ns experimental timescale. Magnetic field probes show clearly motion of the current density around the liner azimuth overmore » 10ns timescales. If breakdown is initiated at one azimuthal location, the current density remains non-uniform even over large spatial extents throughout the current drive. The evolution timescales are suggestive of a resistive diffusion process or uneven current distributions among simultaneously formed but discrete plasma conduction paths.« less

  12. Study of the time-resolved, 3-dimensional current density distribution in solid metallic liners at 1 MA

    DOE PAGES

    Bott-Suzuki, S. C.; Cordaro, S. W.; Caballero Bendixsen, L. S.; ...

    2016-09-01

    We present a study of the time varying current density distribution in solid metallic liner experiments at the 1MA level. Measurements are taken using an array of magnetic field probes which provide 2D triangulation of the average centroid of the drive current in the load at 3 discrete axial positions. These data are correlated with gated optical self-emission imaging which directly images the breakdown and plasma formation region. Results show that the current density is azimuthally non-uniform, and changes significantly throughout the 100ns experimental timescale. Magnetic field probes show clearly motion of the current density around the liner azimuth overmore » 10ns timescales. If breakdown is initiated at one azimuthal location, the current density remains non-uniform even over large spatial extents throughout the current drive. The evolution timescales are suggestive of a resistive diffusion process or uneven current distributions among simultaneously formed but discrete plasma conduction paths.« less

  13. Evaluation of a Compact Hybrid Brain-Computer Interface System

    PubMed Central

    Müller, Klaus-Robert; Schmitz, Christoph H.

    2017-01-01

    We realized a compact hybrid brain-computer interface (BCI) system by integrating a portable near-infrared spectroscopy (NIRS) device with an economical electroencephalography (EEG) system. The NIRS array was located on the subjects' forehead, covering the prefrontal area. The EEG electrodes were distributed over the frontal, motor/temporal, and parietal areas. The experimental paradigm involved a Stroop word-picture matching test in combination with mental arithmetic (MA) and baseline (BL) tasks, in which the subjects were asked to perform either MA or BL in response to congruent or incongruent conditions, respectively. We compared the classification accuracies of each of the modalities (NIRS or EEG) with that of the hybrid system. We showed that the hybrid system outperforms the unimodal EEG and NIRS systems by 6.2% and 2.5%, respectively. Since the proposed hybrid system is based on portable platforms, it is not confined to a laboratory environment and has the potential to be used in real-life situations, such as in neurorehabilitation. PMID:28373984

  14. Evaluation of a Compact Hybrid Brain-Computer Interface System.

    PubMed

    Shin, Jaeyoung; Müller, Klaus-Robert; Schmitz, Christoph H; Kim, Do-Won; Hwang, Han-Jeong

    2017-01-01

    We realized a compact hybrid brain-computer interface (BCI) system by integrating a portable near-infrared spectroscopy (NIRS) device with an economical electroencephalography (EEG) system. The NIRS array was located on the subjects' forehead, covering the prefrontal area. The EEG electrodes were distributed over the frontal, motor/temporal, and parietal areas. The experimental paradigm involved a Stroop word-picture matching test in combination with mental arithmetic (MA) and baseline (BL) tasks, in which the subjects were asked to perform either MA or BL in response to congruent or incongruent conditions, respectively. We compared the classification accuracies of each of the modalities (NIRS or EEG) with that of the hybrid system. We showed that the hybrid system outperforms the unimodal EEG and NIRS systems by 6.2% and 2.5%, respectively. Since the proposed hybrid system is based on portable platforms, it is not confined to a laboratory environment and has the potential to be used in real-life situations, such as in neurorehabilitation.

  15. Unified Access Architecture for Large-Scale Scientific Datasets

    NASA Astrophysics Data System (ADS)

    Karna, Risav

    2014-05-01

    Data-intensive sciences have to deploy diverse large scale database technologies for data analytics as scientists have now been dealing with much larger volume than ever before. While array databases have bridged many gaps between the needs of data-intensive research fields and DBMS technologies (Zhang 2011), invocation of other big data tools accompanying these databases is still manual and separate the database management's interface. We identify this as an architectural challenge that will increasingly complicate the user's work flow owing to the growing number of useful but isolated and niche database tools. Such use of data analysis tools in effect leaves the burden on the user's end to synchronize the results from other data manipulation analysis tools with the database management system. To this end, we propose a unified access interface for using big data tools within large scale scientific array database using the database queries themselves to embed foreign routines belonging to the big data tools. Such an invocation of foreign data manipulation routines inside a query into a database can be made possible through a user-defined function (UDF). UDFs that allow such levels of freedom as to call modules from another language and interface back and forth between the query body and the side-loaded functions would be needed for this purpose. For the purpose of this research we attempt coupling of four widely used tools Hadoop (hadoop1), Matlab (matlab1), R (r1) and ScaLAPACK (scalapack1) with UDF feature of rasdaman (Baumann 98), an array-based data manager, for investigating this concept. The native array data model used by an array-based data manager provides compact data storage and high performance operations on ordered data such as spatial data, temporal data, and matrix-based data for linear algebra operations (scidbusr1). Performances issues arising due to coupling of tools with different paradigms, niche functionalities, separate processes and output data formats have been anticipated and considered during the design of the unified architecture. The research focuses on the feasibility of the designed coupling mechanism and the evaluation of the efficiency and benefits of our proposed unified access architecture. Zhang 2011: Zhang, Ying and Kersten, Martin and Ivanova, Milena and Nes, Niels, SciQL: Bridging the Gap Between Science and Relational DBMS, Proceedings of the 15th Symposium on International Database Engineering Applications, 2011. Baumann 98: Baumann, P., Dehmel, A., Furtado, P., Ritsch, R., Widmann, N., "The Multidimensional Database System RasDaMan", SIGMOD 1998, Proceedings ACM SIGMOD International Conference on Management of Data, June 2-4, 1998, Seattle, Washington, 1998. hadoop1: hadoop.apache.org, "Hadoop", http://hadoop.apache.org/, [Online; accessed 12-Jan-2014]. scalapack1: netlib.org/scalapack, "ScaLAPACK", http://www.netlib.org/scalapack,[Online; accessed 12-Jan-2014]. r1: r-project.org, "R", http://www.r-project.org/,[Online; accessed 12-Jan-2014]. matlab1: mathworks.com, "Matlab Documentation", http://www.mathworks.de/de/help/matlab/,[Online; accessed 12-Jan-2014]. scidbusr1: scidb.org, "SciDB User's Guide", http://scidb.org/HTMLmanual/13.6/scidb_ug,[Online; accessed 01-Dec-2013].

  16. Wireless Computing Architecture III

    DTIC Science & Technology

    2013-09-01

    MIMO Multiple-Input and Multiple-Output MIMO /CON MIMO with concurrent hannel access and estimation MU- MIMO Multiuser MIMO OFDM Orthogonal...compressive sensing \\; a design for concurrent channel estimation in scalable multiuser MIMO networking; and novel networking protocols based on machine...Network, Antenna Arrays, UAV networking, Angle of Arrival, Localization MIMO , Access Point, Channel State Information, Compressive Sensing 16

  17. Terabyte IDE RAID-5 Disk Arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    David A. Sanders et al.

    2003-09-30

    High energy physics experiments are currently recording large amounts of data and in a few years will be recording prodigious quantities of data. New methods must be developed to handle this data and make analysis at universities possible. We examine some techniques that exploit recent developments in commodity hardware. We report on tests of redundant arrays of integrated drive electronics (IDE) disk drives for use in offline high energy physics data analysis. IDE redundant array of inexpensive disks (RAID) prices now are less than the cost per terabyte of million-dollar tape robots! The arrays can be scaled to sizes affordablemore » to institutions without robots and used when fast random access at low cost is important.« less

  18. Status On Multi-microsecond Prepulse Technique On Sphinx Machine Going From Nested To Single Wire Array For 800 ns Implosion Time Z-pinch

    NASA Astrophysics Data System (ADS)

    Maury, P.; Calamy, H.; Grunenwald, J.; Lassalle, F.; Zucchini, F.; Loyen, A.; Georges, A.; Morell, A.; Bedoch, J. P.

    2009-01-01

    The Sphinx machine[1] is a 6 MA, 1 μS driver based on the LTD technology, used for Z-pinch experiments. Important improvements of Sphinx radiation output were recently obtained using a multi-microsecond current prepulse[2]. Total power per unit of length is multiplied by a factor of 6 and FWHM divided by a factor of 2.5. Early breakdown of the wires during the prepulse phase dramatically changes the ablation phase leading to an improvement of axial homogeneity of both the implosion and the final radiating column. As a consequence, the cathode bubble observed on classical shots is definitively removed. The implosion is then centered and zippering effect is reduced, leading to simultaneous x-ray emission of the whole length. A great reproducibility is obtained. Nested arrays were used before to mitigate the Rayleigh-Taylor instabilities during the implosion phase. Further experiments with pre-pulse technique are described here were inner array was removed. The goal of these experiments was to see if long prepulse could give stable enough implosion with single array and at the same time increase the η parameter by reducing the mass of the load. Experimental results of single wire array loads of typical dimension 5 cm in height with implosion time between 700 and 900 ns and diameter varying between 80 and 140 mm are given. Parameters of the loads were varying in term of radius and number of wires. Comparisons with nested wire array loads are done and trends are proposed. Characteristics of both the implosion and the final radiating column are shown. 2D MHD numerical simulations of single wire array become easier as there is no interaction between outer and inner array anymore. A systematic study was done using injection mass model to benchmark simulation with experiments.

  19. The origin of zircon and the significance of U-Pb ages in high-grade metamorphic rocks: a case study from the Variscan orogenic root (Vosges Mountains, NE France)

    NASA Astrophysics Data System (ADS)

    Skrzypek, E.; Štípská, P.; Cocherie, A.

    2012-12-01

    U-Pb zircon dating is combined with petrology, Zr-in-rutile thermometry and mineral equilibria modelling to discuss zircon petrogenesis and the age of metamorphism in three units of the Variscan Vosges Mountains (NE France). The monotonous gneiss unit shows results at 700-500 Ma, but no Variscan ages. The varied gneiss unit preserves ages between 600 and 460 Ma and a Variscan group at 340-335 Ma. Zircon analyses from the felsic granulite unit define a continuous array of ages between 500 and 340 Ma. In varied gneiss samples, zoned garnet includes kyanite and rutile and is surrounded by matrix sillimanite and cordierite. In a pseudosection, it points to peak conditions of ~16 kbar/850 °C followed by isothermal decompression to 8-10 kbar/820-860 °C. In felsic granulite samples, the assemblage K-feldspar-garnet-kyanite-Zr-rich rutile is replaced by sillimanite and Zr-poor rutile. Modelling these assemblages supports minimum conditions of ~13 kbar/925 °C, and a subsequent P-T decrease to 6.5-8.5 kbar/800-820 °C. The internal structure and chemistry of zircons, and modelling of zircon dissolution/growth along the inferred P-T paths are used to discuss the significance of the U-Pb ages. In the monotonous unit, inherited zircon ages of 700-500 Ma point to sedimentation during the Late Cambrian, while medium-grade metamorphism did not allow the formation of Variscan zircon domains. In both the varied gneiss and felsic granulite units, zircons with a blurred oscillatory-zoned pattern could reflect solid-state recrystallization of older grains during HT metamorphism, whereas zircons with a dark cathodoluminescence pattern are thought to derive from crystallization of an anatectic melt during cooling at middle pressure conditions. The present work proposes that U-Pb zircon ages of ca. 340 Ma probably reflect the end of a widespread HT metamorphic event at middle crustal level.

  20. [MaRS Project

    NASA Technical Reports Server (NTRS)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  1. Data Requirement (DR) MA-03: Payload missions integration. [Spacelab payloads

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Project management and payload integration requirements definition activities are reported. Mission peculiar equipment; systems integration; ground operations analysis and requirement definition; safety and quality assurance; and support systems development are examined for payloads planned for the following missions: EOM-1; SL-2; Sl-3 Astro-1; MSL-2; EASE/ACCESS; MPESS; and the middeck ADSF flight.

  2. Support Services for Higher Degree Research Students: A Survey of Three Australian Universities

    ERIC Educational Resources Information Center

    Silva, Pujitha; Woodman, Karen; Taji, Acram; Travelyan, James; Samani, Shamim; Sharda, Hema; Narayanaswamy, Ramesh; Lucey, Anthony; Sahama, Tony; Yarlagadda, Prasad K. D. V.

    2016-01-01

    A survey was conducted across three Australian universities to identify the types and format of support services available for higher degree research (HDR, or MA and Ph.D.) students. The services were classified with regards to availability, location and accessibility. A comparative tool was developed to help institutions categorise their services…

  3. Explaining the Mathematical Creativity of a Young Boy: An Interdisciplinary Venture between Mathematics Education and Psychoanalysis

    ERIC Educational Resources Information Center

    Krummheuer, Götz; Leuzinger-Bohleber, Marianne; Müller-Kirchof, Marion; Münz, Melanie; Vogel, Rose

    2013-01-01

    First results of the project "Mathematical Creativity of Children at Risk" (MaKreKi) will be presented. The project is conducted in the interdisciplinary research center "Individual Development and Adaptive Education of Children at Risk" (IDeA [http://www.idea-frankfurt.eu; accessed 7 June 2013]). Combining a…

  4. Optimizing Satellite Communications With Adaptive and Phased Array Antennas

    NASA Technical Reports Server (NTRS)

    Ingram, Mary Ann; Romanofsky, Robert; Lee, Richard Q.; Miranda, Felix; Popovic, Zoya; Langley, John; Barott, William C.; Ahmed, M. Usman; Mandl, Dan

    2004-01-01

    A new adaptive antenna array architecture for low-earth-orbiting satellite ground stations is being investigated. These ground stations are intended to have no moving parts and could potentially be operated in populated areas, where terrestrial interference is likely. The architecture includes multiple, moderately directive phased arrays. The phased arrays, each steered in the approximate direction of the satellite, are adaptively combined to enhance the Signal-to-Noise and Interference-Ratio (SNIR) of the desired satellite. The size of each phased array is to be traded-off with the number of phased arrays, to optimize cost, while meeting a bit-error-rate threshold. Also, two phased array architectures are being prototyped: a spacefed lens array and a reflect-array. If two co-channel satellites are in the field of view of the phased arrays, then multi-user detection techniques may enable simultaneous demodulation of the satellite signals, also known as Space Division Multiple Access (SDMA). We report on Phase I of the project, in which fixed directional elements are adaptively combined in a prototype to demodulate the S-band downlink of the EO-1 satellite, which is part of the New Millennium Program at NASA.

  5. Life: the first two billion years

    PubMed Central

    Bergmann, Kristin D.; Strauss, Justin V.

    2016-01-01

    Microfossils, stromatolites, preserved lipids and biologically informative isotopic ratios provide a substantial record of bacterial diversity and biogeochemical cycles in Proterozoic (2500–541 Ma) oceans that can be interpreted, at least broadly, in terms of present-day organisms and metabolic processes. Archean (more than 2500 Ma) sedimentary rocks add at least a billion years to the recorded history of life, with sedimentological and biogeochemical evidence for life at 3500 Ma, and possibly earlier; phylogenetic and functional details, however, are limited. Geochemistry provides a major constraint on early evolution, indicating that the first bacteria were shaped by anoxic environments, with distinct patterns of major and micronutrient availability. Archean rocks appear to record the Earth's first iron age, with reduced Fe as the principal electron donor for photosynthesis, oxidized Fe the most abundant terminal electron acceptor for respiration, and Fe a key cofactor in proteins. With the permanent oxygenation of the atmosphere and surface ocean ca 2400 Ma, photic zone O2 limited the access of photosynthetic bacteria to electron donors other than water, while expanding the inventory of oxidants available for respiration and chemoautotrophy. Thus, halfway through Earth history, the microbial underpinnings of modern marine ecosystems began to take shape. This article is part of the themed issue ‘The new bacteriology’. PMID:27672146

  6. Acculturation Differences in Communicating Information about Child Mental Health Between Latino Parents and Primary Care Providers

    PubMed Central

    Lê Cook, Benjamin; Brown, Jonathan D.; Loder, Stephen; Wissow, Larry

    2014-01-01

    Background Significant Latino-white disparities in youth mental health care access and quality exist yet little is known about Latino parents’ communication with providers about youth mental health and the role of acculturation in influencing this communication. Methods We estimated regression models to assess the association between time in the U.S. and the number of psychosocial issues discussed with the medical assistant (MA) and doctor, adjusting for child and parent mental health and sociodemographics. Other proxies of acculturation were also investigated including measures of Spanish and English language proficiency and nativity. Results Parent’s length of time in the U.S. was positively associated with their communication of: their child’s psychosocial problems with their child’s MA, stress in their own life with their child’s MA, and their child’s school problems with their child’s doctor. These differences were especially apparent for parents living in the U.S. for greater than ten years. Parent-child language discordance, parent and child nativity were also significantly associated with communication of psychosocial problems. Discussion Greater provider and MA awareness of variation in resistance to communicating psychosocial issues could improve communication, and improve the prevention, diagnosis and treatment of youth mental illness. PMID:24705736

  7. Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Crew, Jennifer R.; Falzari, Kanakeshwari; DiMario, Joseph X., E-mail: joseph.dimario@rosalindfranklin.edu

    Vertebrate skeletal muscle fiber types are defined by a broad array of differentially expressed contractile and metabolic protein genes. The mechanisms that establish and maintain these different fiber types vary throughout development and with changing functional demand. Chicken skeletal muscle fibers can be generally categorized as fast and fast/slow based on expression of the slow myosin heavy chain 2 (MyHC2) gene in fast/slow muscle fibers. To investigate the cellular and molecular mechanisms that control fiber type formation in secondary or fetal muscle fibers, myoblasts from the fast pectoralis major (PM) and fast/slow medial adductor (MA) muscles were isolated, allowed tomore » differentiate in vitro, and electrically stimulated. MA muscle fibers were induced to express the slow MyHC2 gene by electrical stimulation, whereas PM muscle fibers did not express the slow MyHC2 gene under identical stimulation conditions. However, PM muscle fibers did express the slow MyHC2 gene when electrical stimulation was combined with inhibition of inositol triphosphate receptor (IP3R) activity. Electrical stimulation was sufficient to increase nuclear localization of expressed nuclear-factor-of-activated-T-cells (NFAT), NFAT-mediated transcription, and slow MyHC2 promoter activity in MA muscle fibers. In contrast, both electrical stimulation and inhibitors of IP3R activity were required for these effects in PM muscle fibers. Electrical stimulation also increased levels of peroxisome-proliferator-activated receptor-{gamma} co-activator-1 (PGC-1{alpha}) protein in PM and MA muscle fibers. These results indicate that MA muscle fibers can be induced by electrical stimulation to express the slow MyHC2 gene and that fast PM muscle fibers are refractory to stimulation-induced slow MyHC2 gene expression due to fast PM muscle fiber specific cellular mechanisms involving IP3R activity.« less

  8. Lead mobilization during tectonic reactivation of the western Baltic Shield

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Romer, R.L.; Wright, J.E.

    Lead isotope data from sulfide deposits of the western part of the Baltic Shield define mixing lines in the [sup 206]Pb/[sup 204]Pb-[sup 207]Pb/[sup 204]Pb diagram. Lead from two types of sulfide deposits have been investigated: (1) Exhalative and volcanogenic deposits that are syngenetic with their host rocks; and (2) vein deposits. The syngenetic deposits locally show a very wide range of lead isotopic compositions that reflect a variable addition of highly radiogenic lead, while the vein deposits, although they have radiogenic lead isotopic compositions, exhibit only limited isotopic variations. In different provinces of the shield, both types of deposits fallmore » on the same lead mixing array. The slope of the lead mixing lines varies as a function of the age of basement rocks and the age of the tectonic event which produced the lead mobilization and therefore relates the source rock age with the age of lead mobilization. Calculated mixing ages fall into several short time periods that correspond either to orogenic events or to major phases of continental rifting. The orogenic events are the ca 360--430 Ma Caledonian, ca 900--1100 Ma Sveconorwegian, and the ca 1800--1900 Ma Svecofennian orogenic cycles. The rifting events correspond to the formation of the ca 280 Ma Oslo rift and the Ordovician (ca 450 Ma) graben system in the area of the present Gulf of Bothnia. Each mixing age indicates that lead was mobilized, probably as a consequence of mild thermal disturbances, and that the crust was permeable to lead migration. The data show that the geographic distribution of sulfide deposits with highly radiogenic lead isotopic compositions coincides with old graben systems, orogenic belts, and orogenic forelands on the Baltic Shield. The ages of vein deposits and their geographic distribution demonstrate multiple tectonic reactivation of the interior of the Baltic Shield in response to orogenic events at its margin. 68 refs., 6 refs., 4 tabs.« less

  9. A combined Sm-Nd, Rb-Sr, and U-Pb isotopic study of Mg-suite norite 78238: Further evidence for early differentiation of the Moon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edmunson, J; E.Borg, L; Nyquist, L E

    2008-11-17

    Lunar Mg-suite norite 78238 was dated using the Sm-Nd, Rb-Sr, and U-Pb isotopic systems in order to constrain the age of lunar magma ocean solidification and the beginning of Mg-suite magmatism, as well as to provide a direct comparison between the three isotopic systems. The Sm-Nd isotopic system yields a crystallization age for 78238 of 4334 {+-} 37 Ma and an initial {var_epsilon}{sub Nd}{sup 143} value of -0.27 {+-} 0.74. The age-initial {var_epsilon}{sub Nd}{sup 143} (T-I) systematics of a variety of KREEP-rich samples, including 78238 and other Mg-suite rocks, KREEP basalts, and olivine cumulate NWA 773, suggest that lunar differentiationmore » was completed by 4492 {+-} 61 Ma assuming a Chondritic Uniform Reservoir bulk composition for the Moon. The Rb-Sr isotopic systematics of 78238 were disturbed by post-crystallization processes. Nevertheless, selected data points yield two Rb-Sr isochrons. One is concordant with the Sm-Nd crystallization age, 4366 {+-} 53 Ma. The other is 4003 {+-} 95 Ma and is concordant with an Ar-Ar age for 78236. The {sup 207}Pb-{sup 206}Pb age of 4333 {+-} 59 Ma is concordant with the Sm-Nd age. The U-Pb isotopic systematics of 78238 yield linear arrays equivalent to younger ages than the Pb-Pb system, and may reflect fractionation of U and Pb during sample handling. Despite the disturbed nature of the U-Pb systems, a time-averaged {mu} ({sup 238}U/{sup 204}Pb) value of the source can be estimated at 27 {+-} 30 from the Pb-Pb isotopic systematics. Because KREEP-rich samples are likely to be derived from source regions with the highest U/Pb ratios, the relatively low {mu} value calculated for the 78238 source suggests the bulk Moon does not have an exceedingly high {mu} value.« less

  10. The Ma Gene for Complete-Spectrum Resistance to Meloidogyne Species in Prunus Is a TNL with a Huge Repeated C-Terminal Post-LRR Region1[C][W

    PubMed Central

    Claverie, Michel; Dirlewanger, Elisabeth; Bosselut, Nathalie; Van Ghelder, Cyril; Voisin, Roger; Kleinhentz, Marc; Lafargue, Bernard; Abad, Pierre; Rosso, Marie-Noëlle; Chalhoub, Boulos; Esmenjaud, Daniel

    2011-01-01

    Root-knot nematode (RKN) Meloidogyne species are major polyphagous pests of most crops worldwide, and cultivars with durable resistance are urgently needed because of nematicide bans. The Ma gene from the Myrobalan plum (Prunus cerasifera) confers complete-spectrum, heat-stable, and high-level resistance to RKN, which is remarkable in comparison with the Mi-1 gene from tomato (Solanum lycopersicum), the sole RKN resistance gene cloned. We report here the positional cloning and the functional validation of the Ma locus present at the heterozygous state in the P.2175 accession. High-resolution mapping totaling over 3,000 segregants reduced the Ma locus interval to a 32-kb cluster of three Toll/Interleukin1 Receptor-Nucleotide Binding Site-Leucine-Rich Repeat (LRR) genes (TNL1–TNL3), including a pseudogene (TNL2) and a truncated gene (TNL3). The sole complete gene in this interval (TNL1) was validated as Ma, as it conferred the same complete-spectrum and high-level resistance (as in P.2175) using its genomic sequence and native promoter region in Agrobacterium rhizogenes-transformed hairy roots and composite plants. The full-length cDNA (2,048 amino acids) of Ma is the longest of all Resistance genes cloned to date. Its TNL structure is completed by a huge post-LRR (PL) sequence (1,088 amino acids) comprising five repeated carboxyl-terminal PL exons with two conserved motifs. The amino-terminal region (213 amino acids) of the LRR exon is conserved between alleles and contrasts with the high interallelic polymorphisms of its distal region (111 amino acids) and of PL domains. The Ma gene highlights the importance of these uncharacterized PL domains, which may be involved in pathogen recognition through the decoy hypothesis or in nuclear signaling. PMID:21482634

  11. Design and Implementation of A DICOM PACS With Secure Access Via Internet

    DTIC Science & Technology

    2001-10-25

    which we have called SINFIM ( Sistema de INFormación de Imágenes Médicas). This system permits the automatic acquisition of DICOM images [2] [3...1] MA. Martínez, AJR. Jiménez, BV. Medina, LJ. Azpiroz. “Los Sistemas PACS”. [Last access 08/12/2000]. Available URL http://itzamna.uam.mx...junio, por el que se aprueba el Reglamento de medidas de seguridad de los ficheros automatizados que contengan datos de carácter personal” (Boletín Oficial del Estado, número 151, de 25 de junio de 1999)

  12. High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip

    PubMed Central

    Issadore, David; Franke, Thomas; Brown, Keith A.; Hunt, Thomas P.; Westervelt, Robert M.

    2010-01-01

    A hybrid integrated circuit (IC) / microfluidic chip is presented that independently and simultaneously traps and moves microscopic objects suspended in fluid using both electric and magnetic fields. This hybrid chip controls the location of dielectric objects, such as living cells and drops of fluid, on a 60 × 61 array of pixels that are 30 × 38 μm2 in size, each of which can be individually addressed with a 50 V peak-to-peak, DC to 10 MHz radio frequency voltage. These high voltage pixels produce electric fields above the chip’s surface with a magnitude , resulting in strong dielectrophoresis (DEP) forces . Underneath the array of DEP pixels there is a magnetic matrix that consists of two perpendicular sets of 60 metal wires running across the chip. Each wire can be sourced with 120 mA to trap and move magnetically susceptible objects using magnetophoresis (MP). The DEP pixel array and magnetic matrix can be used simultaneously to apply forces to microscopic objects, such as living cells or lipid vesicles, that are tagged with magnetic nanoparticles. The capabilities of the hybrid IC / microfluidic chip demonstrated in this paper provide important building blocks for a platform for biological and chemical applications. PMID:20625468

  13. High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip.

    PubMed

    Issadore, David; Franke, Thomas; Brown, Keith A; Hunt, Thomas P; Westervelt, Robert M

    2009-12-01

    A hybrid integrated circuit (IC) / microfluidic chip is presented that independently and simultaneously traps and moves microscopic objects suspended in fluid using both electric and magnetic fields. This hybrid chip controls the location of dielectric objects, such as living cells and drops of fluid, on a 60 × 61 array of pixels that are 30 × 38 μm(2) in size, each of which can be individually addressed with a 50 V peak-to-peak, DC to 10 MHz radio frequency voltage. These high voltage pixels produce electric fields above the chip's surface with a magnitude , resulting in strong dielectrophoresis (DEP) forces . Underneath the array of DEP pixels there is a magnetic matrix that consists of two perpendicular sets of 60 metal wires running across the chip. Each wire can be sourced with 120 mA to trap and move magnetically susceptible objects using magnetophoresis (MP). The DEP pixel array and magnetic matrix can be used simultaneously to apply forces to microscopic objects, such as living cells or lipid vesicles, that are tagged with magnetic nanoparticles. The capabilities of the hybrid IC / microfluidic chip demonstrated in this paper provide important building blocks for a platform for biological and chemical applications.

  14. 3D ZnIn2S4 nanosheet/TiO2 nanowire arrays and their efficient photocathodic protection for 304 stainless steel

    NASA Astrophysics Data System (ADS)

    Sun, Wenxia; Wei, Na; Cui, Hongzhi; Lin, Yuan; Wang, Xinzhen; Tian, Jian; Li, Jian; Wen, Jing

    2018-03-01

    A well-designed heterostructure engineered ZnIn2S4 nanosheet/TiO2 nanowire arrays photoanode is investigated for photocathodic protection. The ZnIn2S4 nanosheets are distributed uniformly on the surface of the TiO2 nanowire by a hydrothermal method. The stem-and-leaf-like ZnIn2S4 nanosheet/TiO2 nanowire arrays exhibit excellent photoelectrochemical properties, owing to the energy band structure and large surface area. A maximum photocurrent density of 2 mA cm-2 is achieved for the ZnIn2S4 nanosheet/TiO2 nanowire composite film for a 6 h reaction time under white illumination. Moreover, the potential of the 304 stainless steel coupled with the composite film immediately shifts negatively to -1.17 V (vs. SCE), which is significantly lower than the corrosion potential (-0.201 V vs. SCE). Thus, the composite film offers a superior photocathodic protection for stainless steel against corrosion by a NaCl solution. This study provides a promising approach for the design and synthesis of composite films with enhanced photoelectrochemical performance.

  15. Radiation characteristics and implosion dynamics of tungsten wire array Z-pinches on the YANG accelerator

    NASA Astrophysics Data System (ADS)

    Huang, Xian-Bin; Yang, Li-Bing; Li, Jing; Zhou, Shao-Tong; Ren, Xiao-Dong; Zhang, Si-Qun; Dan, Jia-Kun; Cai, Hong-Chun; Duan, Shu-Chao; Chen, Guang-Hua; Zhang, Zheng-Wei; Ouyang, Kai; Li, Jun; Zhang, Zhao-Hui; Zhou, Rong-Guo; Wang, Gui-Lin

    2012-05-01

    We investigated the radiation characteristics and implosion dynamics of low-wire-number cylindrical tungsten wire array Z-pinches on the YANG accelerator with a peak current 0.8-1.1 MA and a rising time ~ 90 ns. The arrays are made up of (8-32) × 5 μm wires 6/10 mm in diameter and 15 mm in height. The highest X-ray power obtained in the experiments was about 0.37 TW with the total radiation energy ~ 13 kJ and the energy conversion efficiency ~ 9% (24 × 5 μm wires, 6 mm in diameter). Most of the X-ray emissions from tungsten Z-pinch plasmas were distributed in the spectral band of 100-600 eV, peaked at 250 and 375 eV. The dominant wavelengths of the wire ablation and the magneto-Rayleigh—Taylor instability were found and analyzed through measuring the time-gated self-emission and laser interferometric images. Through analyzing the implosion trajectories obtained by an optical streak camera, the run-in velocities of the Z-pinch plasmas at the end of the implosion phase were determined to be about (1.3-2.1) × 107 cm/s.

  16. Parallel Optical Random Access Memory (PORAM)

    NASA Technical Reports Server (NTRS)

    Alphonse, G. A.

    1989-01-01

    It is shown that the need to minimize component count, power and size, and to maximize packing density require a parallel optical random access memory to be designed in a two-level hierarchy: a modular level and an interconnect level. Three module designs are proposed, in the order of research and development requirements. The first uses state-of-the-art components, including individually addressed laser diode arrays, acousto-optic (AO) deflectors and magneto-optic (MO) storage medium, aimed at moderate size, moderate power, and high packing density. The next design level uses an electron-trapping (ET) medium to reduce optical power requirements. The third design uses a beam-steering grating surface emitter (GSE) array to reduce size further and minimize the number of components.

  17. A seismological constraint on the age of a subducting slab: the Huatung basin offshore Taiwan

    NASA Astrophysics Data System (ADS)

    Chang, Y.; Kuo, B.

    2010-12-01

    At the northwestern corner of the Philippine basin, collision and subduction are taking place simultaneously as the Philippine Sea plate is obliquely subducting beneath the Ryukyu trench and NE Taiwan. What is engaging in these processes is the Huatung basin (HB) lithosphere, a small piece of oceanic lithosphere which, unlike the rest of the Philippine Sea plate, is controversial in its age and structure. Because certain ages of lithosphere correspond to certain overall velocity structures, we examine how old the subducting slab of the HB has to be to satisfy seismological observations. We select from broadband seismic networks on Taiwan a rough linear array that points to the events in the Kuril trench region, rendering a slab dipping towards the upcoming P wave field. The slab thus defocuses seismic energy and produces an amplitude low along the array with magnitude and spread controlled by the age of the slab. We employ a 2D finite-difference waveform technique and experimented with 2 types of slab models with various ages: a simplistic conduction model and a high-resolution slab-wedge convection model. The older and thicker the slab, the more widely the predicted amplitude low spreads. Comparison with the observations indicates that the best slab ages fall into 20-50 Ma. This is at odds with the 125 Ma Ar-Ar dating model. Now the issue is not how to make the chronologically old lithosphere seismologically young, but why those basaltic rock samples dated to be old are located on the HB.

  18. Family Abductors: Descriptive Profiles and Preventive Interventions. Juvenile Justice Bulletin.

    ERIC Educational Resources Information Center

    Johnston, Janet R.; Girdner, Linda K.

    Parental abduction encompasses a broad array of illegal behaviors that involves one parent taking, detaining, concealing, or enticing away his or her child from the parent having custodial access. When the abducted parent intends to permanently alter custodial access by hiding the child or removing the child to another locale, the effects on the…

  19. Statistical Validation of a New Python-based Military Workforce Simulation Model

    DTIC Science & Technology

    2014-12-30

    also having a straightforward syntax that is accessible to non-programmers. Furthermore, it is supported by an impressive variety of scientific... accessed by a given element of model logic or line of code. For example, in Arena, data arrays, queues and the simulation clock are part of the...global scope and are therefore accessible anywhere in the model. The disadvantage of scopes is that all names in a scope must be unique. If more than

  20. Genetic Identity in Genebanks: Application of the SolCAP 12K SNP Array in Fingerprinting and Diversity Analysis in the Global In Trust Potato Collection.

    PubMed

    Ellis, David; Chavez, Oswaldo; Coombs, Joseph J; Soto, Julian V; Gomez, Rene; Douches, David S; Panta, Ana; Silvestre, Rocio; Anglin, Noelle Lynette

    2018-05-24

    Breeders rely on genetic integrity of material from genebanks, however, mislabeling and errors in original data can occur. Paired samples of original material and their in vitro counterparts from 250 diverse potato landrace accessions from the International Potato Center (CIP), were fingerprinted using the Infinium 12K V2 Potato Array to confirm genetic identity and evaluate genetic diversity. Diploid, triploid, and tetraploid accessions were included representing seven cultivated potato taxa (Hawkes, 1990). Fingerprints between mother field plants and in vitro clones, were used to evaluate identity, relatedness, and ancestry. Clones of the same accession grouped together, however eleven (4.4%) accessions were mismatches genetically. SNP genotypes were used to construct a phylogeny to evaluate inter- and intraspecific relationships and population structure. Data suggests that the triploids evaluated are genetically similar. STRUCTURE analysis identified several putative hybrids and suggests six populations with significant gene flow between. This study provides a model for genetic identity of plant genetic resources collections as mistakes in conservation of these collections and in genebanks is a reality and confirmed identity is critical for breeders and other users of these collections, as well as for quality management programs and to provide insights into the diversity of the accessions evaluated.

  1. Electrical Components for Marine Renewable Energy Arrays: A Techno-Economic Review

    DOE PAGES

    Collin, Adam J.; Nambiar, Anup J.; Bould, David; ...

    2017-11-27

    This paper presents a review of the main electrical components that are expected to be present in marine renewable energy arrays. The review is put in context by appraising the current needs of the industry and identifying the key components required in both device and array-scale developments. For each component, electrical, mechanical and cost considerations are discussed; with quantitative data collected during the review made freely available for use by the community via an open access online repository. Here, this data collection updates previous research and addresses gaps specific to emerging offshore technologies, such as marine and floating wind, andmore » provides a comprehensive resource for the techno-economic assessment of offshore energy arrays.« less

  2. Electrical Components for Marine Renewable Energy Arrays: A Techno-Economic Review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Collin, Adam J.; Nambiar, Anup J.; Bould, David

    This paper presents a review of the main electrical components that are expected to be present in marine renewable energy arrays. The review is put in context by appraising the current needs of the industry and identifying the key components required in both device and array-scale developments. For each component, electrical, mechanical and cost considerations are discussed; with quantitative data collected during the review made freely available for use by the community via an open access online repository. Here, this data collection updates previous research and addresses gaps specific to emerging offshore technologies, such as marine and floating wind, andmore » provides a comprehensive resource for the techno-economic assessment of offshore energy arrays.« less

  3. Advancing High Current Startup via Localized Helicity Injection in the PEGASUS Toroidal Experiment

    NASA Astrophysics Data System (ADS)

    Hinson, E. T.; Barr, J. L.; Bongard, M. W.; Burke, M. G.; Fonck, R. J.; Perry, J. M.; Redd, A. J.; Schlossberg, D. J.

    2013-10-01

    Non-solenoidal startup via local helicity injection (LHI) and poloidal field induction is used to produce Ip = 0 . 17 MA tokamak discharges. Impurity contamination has been reduced to negligible levels by use of conical frustum cathode geometry and local scraper limiters. Attainable currents are governed by global limits of helicity and energy balance, and Taylor relaxation. A simple lumped parameter model based on these limits is used to project discharge evolution, and indicates that attaining 1 MA in NSTX-U will require LHI-driven effective loop voltages to dominate contributions from dLp / dt . This regime contrasts with results to date and will be tested at 0.3 MA in PEGASUS with a new integrated multi-injector array. Injector impedance characteristics are consistent with magnetically-limited regimes observed in higher-power foilless diodes. Bursts of MHD are measured on time scales of order ~ 100 μ s, and correlate with rapid equilibrium changes, discrete rises in Ip, redistribution of the toroidal current, ion heating (Ti ~ 1 keV), transient drops in injector voltage, and apparent n = 1 line-tied kink activity at the injector. NIMROD simulations of high-field-side HI discharges in PEGASUS are in qualitative agreement, suggesting Ip buildup results from inward propagating toroidal current loops created by intermittent reconnection of injected current streams. Work supported by US DOE Grant DE-FG02-96ER54375.

  4. The `DODO' survey - I. Limits on ultra-cool substellar and planetary-mass companions to van Maanen's star (vMa2)

    NASA Astrophysics Data System (ADS)

    Burleigh, M. R.; Clarke, F. J.; Hogan, E.; Brinkworth, C. S.; Bergeron, P.; Dufour, P.; Dobbie, P. D.; Levan, A. J.; Hodgkin, S. T.; Hoard, D. W.; Wachter, S.

    2008-05-01

    We report limits in the planetary-mass regime for companions around the nearest single white dwarf to the Sun, van Maanen's star (vMa2), from deep J-band imaging with Gemini North and Spitzer Infrared Array Camera (IRAC) mid-IR photometry. We find no resolved common proper motion companions to vMa2 at separations from 3 to 45 arcsec, at a limiting magnitude of J ~ 23. Assuming a total age for the system of 4.1 +/- 1Gyr, and utilizing the latest evolutionary models for substellar objects, this limit is equivalent to companion masses >7 +/- 1MJup(Teff ~ 300K). Taking into account the likely orbital evolution of very low mass companions in the post-main-sequence phase, these J-band observations effectively survey orbits around the white dwarf progenitor from 3 to 50au. There is no flux excess detected in any of the complimentary Spitzer IRAC mid-IR filters. We fit a white dwarf model atmosphere to the optical BVRI, JHK and IRAC photometry. The best solution gives Teff = 6030 +/- 240K, logg = 8.10 +/- 0.04 and, hence, M = 0.633 +/- 0.022Msolar. We then place a 3σ upper limit of 10 +/- 2MJup on the mass of any unresolved companion in the 4.5μm band.

  5. Array based Discovery of Aptamer Pairs (Open Access Publisher’s Version)

    DTIC Science & Technology

    2014-12-11

    Array-based Discovery of Aptamer Pairs Minseon Cho,†,‡ Seung Soo Oh,‡ Jeff Nie,§ Ron Stewart,§ Monte J. Radeke,⊥ Michael Eisenstein,†,‡ Peter J...bidentate” target recognition, with affinities greatly exceeding either monovalent component. DNA aptamers are especially well-suited for such...constructs, because they can be linked via standard synthesis techniques without requiring chemical conjugation. Unfortunately, aptamer pairs are difficult

  6. An amorphous titanium dioxide metal insulator metal selector device for resistive random access memory crossbar arrays with tunable voltage margin

    NASA Astrophysics Data System (ADS)

    Cortese, Simone; Khiat, Ali; Carta, Daniela; Light, Mark E.; Prodromakis, Themistoklis

    2016-01-01

    Resistive random access memory (ReRAM) crossbar arrays have become one of the most promising candidates for next-generation non volatile memories. To become a mature technology, the sneak path current issue must be solved without compromising all the advantages that crossbars offer in terms of electrical performances and fabrication complexity. Here, we present a highly integrable access device based on nickel and sub-stoichiometric amorphous titanium dioxide (TiO2-x), in a metal insulator metal crossbar structure. The high voltage margin of 3 V, amongst the highest reported for monolayer selector devices, and the good current density of 104 A/cm2 make it suitable to sustain ReRAM read and write operations, effectively tackling sneak currents in crossbars without compromising fabrication complexity in a 1 Selector 1 Resistor (1S1R) architecture. Furthermore, the voltage margin is found to be tunable by an annealing step without affecting the device's characteristics.

  7. Pathways to HIV risk and vulnerability among lesbian, gay, bisexual, and transgendered methamphetamine users: a multi-cohort gender-based analysis

    PubMed Central

    2011-01-01

    Background Methamphetamine (MA) use continues to be a major public health concern in many urban settings. We sought to assess potential relationships between MA use and individual, social, and structural HIV vulnerabilities among sexual minority (lesbian, gay, bisexual or transgendered) drug users. Methods Beginning in 2005 and ending in 2008, 2109 drug users were enroled into one of three cohort studies in Vancouver, Canada. We analysed longitudinal data from all self-identified sexual minority participants (n = 248). Logistic regression using generalized estimating equations (GEE) was used to examine the independent correlates of MA use over time. All analyses were stratified by biological sex at birth. Results At baseline, 104 (7.5%) males and 144 (20.4%) females reported sexual minority status, among whom 64 (62.1%) and 58 (40.3%) reported MA use in the past six months, respectively. Compared to heterosexual participants, sexual minority males (odds ratio [OR] = 3.74, p < 0.001) and females (OR = 1.80, p = 0.003) were more likely to report recent MA use. In multivariate analysis, MA use among sexual minority males was associated with younger age (adjusted odds ratio [AOR] = 0.93 per year older, p = 0.011), Aboriginal ancestry (AOR = 2.59, p = 0.019), injection drug use (AOR = 3.98, p < 0.001), having a legal order or area restriction (i.e., "no-go zone") impact access to services or influence where drugs are used or purchased (AOR = 4.18, p = 0.008), unprotected intercourse (AOR = 1.62, p = 0.048), and increased depressive symptoms (AOR = 1.67, p = 0.044). Among females, MA use was associated with injection drug use (AOR = 2.49, p = 0.002), Downtown South residency (i.e., an area known for drug use) (AOR = 1.60, p = 0.047), and unprotected intercourse with sex trade clients (AOR = 2.62, p = 0.027). Conclusions Methamphetamine use was more prevalent among sexual minority males and females and was associated with different sets of HIV risks and vulnerabilities. Our findings suggest that interventions addressing MA-related harms may need to be informed by more nuanced understandings of the intersection between drug use patterns, social and structural HIV vulnerabilities, and gender/sexual identities. In particular, MA-focused prevention and treatment programs tailored to disenfranchised male and female sexual minority youth are recommended. PMID:21214930

  8. An Integrated Geochronological, Petrological, Geochemical and Paleomagnetic Study of Paleoproterozoic and Mesoproterozoic Mafic Dyke Swarms in the Nain Craton, Labrador

    NASA Astrophysics Data System (ADS)

    Sahin, Tugce

    The Nain craton comprises the western, Labrador segment of the larger North Atlantic craton (NAC) which exposes Early through Late Archean gneisses. The NAC is bounded on all sides by Paleoproterozoic collisional orogens that involved either considerable structural reworking (Torngat-Nagssugtoqidian-Lewisian) or the accretion of juvenile arc magmas (Ketilidian-Makkovik). The NAC remains poorly understood compared to other Archean crustal blocks now dispersed globally. Compounding this problem is a lack of reliable paleomagnetic poles for NAC units that predate its assembly into the supercontinent Laurentia by ca. 1800 Ma, which could be used to test neighboring relationships with other cratonic fragments. In order to understand the history of the NAC as part of a possible, larger supercontinent, the record of mafic dyke swarms affecting the craton, particularly those that postdate the Late Archean terrane assembly, were examined in this study. Diabase or gabbroic dyke swarms are invaluable in such studies because their geometries offer possible locus points, they often have a punctuated emplacement and precisely datable crystallization histories, and they have cooling histories and oxide mineralogy amenable to recovering robust paleopoles. Coastal Labrador exposes a number of mafic dykes, some of which are demonstrably Paleoproterozoic (e.g. 2235 Ma Kikkertavak dykes; 2121 Ma Tikkigatsiagak dykes) or Mesoproterozoic (e.g. 1280-1270 Ma Nain and Harp dykes) in age (U-Pb; baddeleyite or zircon). The southern half of the Nain craton (Hopedale block) in particular preserves a rich array of mafic dykes. Dyke cross-cutting relationships are numerous and relatively well exposed, permitting multiple opportunities for paleomagnetic field tests (e.g. baked contact). The results presented here allow understanding of the tectonic evolution of the NAC with implications for strengthened Labrador-Greenland correlations, and testing possible Paleoproterozoic supercontinent reconstructions.

  9. The Evolution of Fire Support Doctrine Was Driven by Airmobile Doctrine and New Weapon Systems During the Vietnam War

    DTIC Science & Technology

    2004-06-18

    army.mil/history/factsheets/army.shtml (accessed on 26 Apr 2004). 7Catchpole, 153. 8Pamela Feltus , Air Power: The Korean War, U.S., [Centennial of...Edgar C., Jr. Tools of War. Boston, MA: Boston Publishing Company, 1984. 87 Feltus , Pamela. Air Power: The Korean War, U.S. Centennial of Flight

  10. Assessment of Food Safety Knowledge of High School and Transition Teachers of Special Needs Students

    ERIC Educational Resources Information Center

    Pivarnik, Lori F.; Patnoad, Martha S.; Richard, Nicole Leydon; Gable, Robert K.; Hirsch, Diane Wright; Madaus, Joseph; Scarpati, Stan; Carbone, Elena

    2009-01-01

    Adolescents with disabilities require access to general education and life skills instruction. Knowledge of food safety for this audience is important for health and valuable for work placement. The objective was to implement a survey to assess high school and transition special education teachers in RI, CT, and MA for food safety knowledge and…

  11. Thermal evolution and exhumation of deep-level batholithic exposures, southernmost Sierra Nevada, California

    USGS Publications Warehouse

    Saleeby, J.; Farley, K.A.; Kistler, R.W.; Fleck, R.J.

    2007-01-01

    The Tehachapi complex lies at the southern end of the Sierra Nevada batholith adjacent to the Neogene-Quaternary Garlock fault. The complex is composed principally of high-pressure (8-10 kbar) Cretaceous batholithic rocks, and it represents the deepest exposed levels of a continuous oblique crustal section through the southern Sierra Nevada batholith. Over the southern ???100 km of this section, structural/petrologic continuity and geochronological data indicate that ???35 km of felsic to intermediate-composition crust was generated by copious arc magmatism primarily between 105 and 99 Ma. In the Tehachapi complex, these batholithic rocks intrude and are bounded to the west by similar-composition gneissic-textured high-pressure batholithic rocks emplaced at ca. 115-110 Ma. This lower crustal complex is bounded below by a regional thrust system, which in Late Cretaceous time tectonically eroded the underlying mantle lithosphere, and in series displaced and underplated the Rand Schist subduction assemblage by low-angle slip from the outboard Franciscan trench. Geophysical and mantle xenolith studies indicate that the remnants of this shallow subduction thrust descend northward through the crust and into the mantle, leaving the mantle lithosphere intact beneath the greater Sierra Nevada batholith. This north-dipping regional structure records an inflection in the Farallon plate, which was segmented into a shallow subduc-tion trajectory to the south and a normal steeper trajectory to the north. We combine new and published data from a broad spectrum of thermochronom-eters that together form a coherent data array constraining the thermal evolution of the complex. Integration of these data with published thermobarometric and petro-genetic data also constrains the tectonically driven decompression and exhumation history of the complex. The timing of arc magmatic construction of the complex, as denoted above, is resolved by a large body of U/Pb zircon ages. High-confidence thermochronometric data track a single retrogressing path commencing from widely established solidus conditions at ca. 100 Ma, and traversing through time-temperature space as follows: (1) Sm/Nd garnet ???770-680 ??C at ca. 102-95 Ma, (2) U/Pb titanite ???750-600 ??C at ca. 102-95 Ma, (3) Ar/Ar hornblende ???570-490 ??C at ca. 94-91 Ma, (4) Rb/Sr biotite ???390-260 ??C at ca. 90-86 Ma, (5) Ar/Ar biotite ???320-240 ??C at ca. 88-85 Ma, and (6) (U-Th)/He zircon ???230-170 ??C at ca. 88-83 Ma. Additional stratigraphic constraints place the complex at surface conditions in Paleocene-early Eocene time (ca. 66-55 Ma). Integration of these results with thermobarometric and structural data, including published data on the underlying Rand Schist, reveals a profound tectonic event whereby rapid cooling and exhumation at rates potentially as high as 100s ??C/m.y. and >5 mm/yr initiated at ca. 98 Ma and peaked between 96 and 94 Ma. Between 93 and 85 Ma, cooling rates remained high, but decelerated with or without significant exhumation. Subsequent cooling and exhumation rates are poorly constrained but were much slower and ultimately resulted in Paleocene-Eocene surface exposure. Initial rapid exhumation and cooling are hypothesized to have been driven by abrupt flattening in the corresponding segment of the Farallon plate and the resulting tectonic erosion of the underlying mantle lithosphere. Protolith as well as meta-morphic pressure-temperature and age constraints on the Rand Schist indicate its rapid low-angle subduction between 93 and 88 Ma. Comparison of the Rand Schist and Tehachapi complex pressure-temperature-time paths in conjunction with structural relations strongly suggest that the schist ascended the equivalent of ???4 kbar relative to the Tehachapi complex by low-angle normal displacement along the Rand fault between 88 and 80 Ma to attain its current underplated structural position. Such extensional tectonism is hypothesized to have been driven by slab rollback

  12. Fabrication of cross-shaped Cu-nanowire resistive memory devices using a rapid, scalable, and designable inorganic-nanowire-digital-alignment technique (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Xu, Wentao; Lee, Yeongjun; Min, Sung-Yong; Park, Cheolmin; Lee, Tae-Woo

    2016-09-01

    Resistive random-access memory (RRAM) is a candidate next generation nonvolatile memory due to its high access speed, high density and ease of fabrication. Especially, cross-point-access allows cross-bar arrays that lead to high-density cells in a two-dimensional planar structure. Use of such designs could be compatible with the aggressive scaling down of memory devices, but existing methods such as optical or e-beam lithographic approaches are too complicated. One-dimensional inorganic nanowires (i-NWs) are regarded as ideal components of nanoelectronics to circumvent the limitations of conventional lithographic approaches. However, post-growth alignment of these i-NWs precisely on a large area with individual control is still a difficult challenge. Here, we report a simple, inexpensive, and rapid method to fabricate two-dimensional arrays of perpendicularly-aligned, individually-conductive Cu-NWs with a nanometer-scale CuxO layer sandwiched at each cross point, by using an inorganic-nanowire-digital-alignment technique (INDAT) and a one-step reduction process. In this approach, the oxide layer is self-formed and patterned, so conventional deposition and lithography are not necessary. INDAT eliminates the difficulties of alignment and scalable fabrication that are encountered when using currently-available techniques that use inorganic nanowires. This simple process facilitates fabrication of cross-point nonvolatile memristor arrays. Fabricated arrays had reproducible resistive switching behavior, high on/off current ratio (Ion/Ioff) 10 6 and extensive cycling endurance. This is the first report of memristors with the resistive switching oxide layer self-formed, self-patterned and self-positioned; we envision that the new features of the technique will provide great opportunities for future nano-electronic circuits.

  13. SecureMA: protecting participant privacy in genetic association meta-analysis.

    PubMed

    Xie, Wei; Kantarcioglu, Murat; Bush, William S; Crawford, Dana; Denny, Joshua C; Heatherly, Raymond; Malin, Bradley A

    2014-12-01

    Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access to data. We introduce a novel cryptographic strategy to securely perform meta-analysis for genetic association studies in large consortia. Our methodology is useful for supporting joint studies among disparate data sites, where privacy or confidentiality is of concern. We validate our method using three multisite association studies. Our research shows that genetic associations can be analyzed efficiently and accurately across substudy sites, without leaking information on individual participants and site-level association summaries. Our software for secure meta-analysis of genetic association studies, SecureMA, is publicly available at http://github.com/XieConnect/SecureMA. Our customized secure computation framework is also publicly available at http://github.com/XieConnect/CircuitService. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. PhylArray: phylogenetic probe design algorithm for microarray.

    PubMed

    Militon, Cécile; Rimour, Sébastien; Missaoui, Mohieddine; Biderre, Corinne; Barra, Vincent; Hill, David; Moné, Anne; Gagne, Geneviève; Meier, Harald; Peyretaillade, Eric; Peyret, Pierre

    2007-10-01

    Microbial diversity is still largely unknown in most environments, such as soils. In order to get access to this microbial 'black-box', the development of powerful tools such as microarrays are necessary. However, the reliability of this approach relies on probe efficiency, in particular sensitivity, specificity and explorative power, in order to obtain an image of the microbial communities that is close to reality. We propose a new probe design algorithm that is able to select microarray probes targeting SSU rRNA at any phylogenetic level. This original approach, implemented in a program called 'PhylArray', designs a combination of degenerate and non-degenerate probes for each target taxon. Comparative experimental evaluations indicate that probes designed with PhylArray yield a higher sensitivity and specificity than those designed by conventional approaches. Applying the combined PhyArray/GoArrays strategy helps to optimize the hybridization performance of short probes. Finally, hybridizations with environmental targets have shown that the use of the PhylArray strategy can draw attention to even previously unknown bacteria.

  15. Two LANL laboratory astrophysics experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Intrator, Thomas P.

    2014-01-24

    Two laboratory experiments are described that have been built at Los Alamos (LANL) to gain access to a wide range of fundamental plasma physics issues germane to astro, space, and fusion plasmas. The overarching theme is magnetized plasma dynamics which includes significant currents, MHD forces and instabilities, magnetic field creation and annihilation, sheared flows and shocks. The Relaxation Scaling Experiment (RSX) creates current sheets and flux ropes that exhibit fully 3D dynamics, and can kink, bounce, merge and reconnect, shred, and reform in complicated ways. Recent movies from a large data set describe the 3D magnetic structure of a drivenmore » and dissipative single flux rope that spontaneously self-saturates a kink instability. Examples of a coherent shear flow dynamo driven by colliding flux ropes will also be shown. The Magnetized Shock Experiment (MSX) uses Field reversed configuration (FRC) experimental hardware that forms and ejects FRCs at 150km/sec. This is sufficient to drive a collision less magnetized shock when stagnated into a mirror stopping field region with Alfven Mach number MA=3 so that super critical shocks can be studied. We are building a plasmoid accelerator to drive Mach numbers MA >> 3 to access solar wind and more exotic astrophysical regimes. Unique features of this experiment include access to parallel, oblique and perpendicular shocks, shock region much larger than ion gyro radii and ion inertial length, room for turbulence, and large magnetic and fluid Reynolds numbers.« less

  16. Access Denied: Should Youth Access to the Internet Be Regulated? A Resource Guide for Teachers.

    ERIC Educational Resources Information Center

    Parrini, Michelle

    Much of the current public discussion in the United States about the Internet and speech rights focuses on the array of materials (particularly sexually explicit materials) that are available on the Internet, the effect of exposure to them on youth development, and whether the material should be regulated. In exploring questions about youth access…

  17. Learning Support for Students with Learning Difficulties in India and Australia: Similarities and Differences

    ERIC Educational Resources Information Center

    Thomas, Grace; Whitten, Janet

    2012-01-01

    In Australia, principles of inclusivity and access are explicit in education policies and are actively supported by government funding. In India, with a vast and diversely managed array of schools, limited resources and an absence of public funding, it cannot be assumed that official principles of access and equity apply. This small-scale study of…

  18. Design and optimization of the plasmonic graphene/InP thin-film solar-cell structure

    NASA Astrophysics Data System (ADS)

    Nematpour, Abedin; Nikoufard, Mahmoud; Mehragha, Rouholla

    2018-06-01

    In this paper, a graphene/InP thin-film Schottky-junction solar cell with a periodic array of plasmonic back-reflector is proposed. In this structure, a single-layer graphene sheet is deposited on the surface of the InP to form a Schottky junction. Then, the layer stack of the proposed solar-cell is optimized to have a maximum optical absorption of 〈A W〉  =  0.985 (98.5%) and short-circuit current density of J sc  =  33.01 mA cm‑2.

  19. CMOS gate array characterization procedures

    NASA Astrophysics Data System (ADS)

    Spratt, James P.

    1993-09-01

    Present procedures are inadequate for characterizing the radiation hardness of gate array product lines prior to personalization because the selection of circuits to be used, from among all those available in the manufacturer's circuit library, is usually uncontrolled. (Some circuits are fundamentally more radiation resistant than others.) In such cases, differences in hardness can result between different designs of the same logic function. Hardness also varies because many gate arrays feature large custom-designed megacells (e.g., microprocessors and random access memories-MicroP's and RAM's). As a result, different product lines cannot be compared equally. A characterization strategy is needed, along with standardized test vehicle(s), methodology, and conditions, so that users can make informed judgments on which gate arrays are best suited for their needs. The program described developed preferred procedures for the radiation characterization of gate arrays, including a gate array evaluation test vehicle, featuring a canary circuit, designed to define the speed versus hardness envelope of the gate array. A multiplier was chosen for this role, and a baseline multiplier architecture is suggested that could be incorporated into an existing standard evaluation circuit chip.

  20. SNPConvert: SNP Array Standardization and Integration in Livestock Species.

    PubMed

    Nicolazzi, Ezequiel Luis; Marras, Gabriele; Stella, Alessandra

    2016-06-09

    One of the main advantages of single nucleotide polymorphism (SNP) array technology is providing genotype calls for a specific number of SNP markers at a relatively low cost. Since its first application in animal genetics, the number of available SNP arrays for each species has been constantly increasing. However, conversely to that observed in whole genome sequence data analysis, SNP array data does not have a common set of file formats or coding conventions for allele calling. Therefore, the standardization and integration of SNP array data from multiple sources have become an obstacle, especially for users with basic or no programming skills. Here, we describe the difficulties related to handling SNP array data, focusing on file formats, SNP allele coding, and mapping. We also present SNPConvert suite, a multi-platform, open-source, and user-friendly set of tools to overcome these issues. This tool, which can be integrated with open-source and open-access tools already available, is a first step towards an integrated system to standardize and integrate any type of raw SNP array data. The tool is available at: https://github. com/nicolazzie/SNPConvert.git.

  1. Three-dimensional hierarchical NiCo2O4 nanowire@Ni3S2 nanosheet core/shell arrays for flexible asymmetric supercapacitors

    NASA Astrophysics Data System (ADS)

    Liu, Bo; Kong, Dezhi; Huang, Zhi Xiang; Mo, Runwei; Wang, Ye; Han, Zhaojun; Cheng, Chuanwei; Yang, Hui Ying

    2016-05-01

    Three-dimensional (3D) hierarchical NiCo2O4@Ni3S2 core/shell arrays on Ni foam were synthesized by a facile, stepwise synthesis approach. The 3D heterogeneous NiCo2O4 nanostructure forms an interconnected web-like scaffold and serves as the core for the Ni3S2 shell. The as-prepared NiCo2O4@Ni3S2 nanowire array (NWA) electrodes exhibited excellent electrochemical performance, such as high specific areal capacitance and excellent cycling stability. The specific areal capacitance of 3.0 F cm-2 at a current density of 5 mA cm-2 is among the highest values and the only 6.7% capacitance decay after 10 000 cycles demonstrates the excellent cycling stability. A flexible asymmetric supercapacitor (ASC) was fabricated with activated carbon (AC) as the anode and the obtained NiCo2O4@Ni3S2 NWAs as the cathode. The ASC device exhibited a high energy density of 1.89 mW h cm-3 at 5.81 W cm-3 and a high power density of 56.33 W cm-3 at 0.94 mW h cm-3. As a result, the hybrid nanoarchitecture opens a new way to design high performance electrodes for electrochemical energy storage applications.Three-dimensional (3D) hierarchical NiCo2O4@Ni3S2 core/shell arrays on Ni foam were synthesized by a facile, stepwise synthesis approach. The 3D heterogeneous NiCo2O4 nanostructure forms an interconnected web-like scaffold and serves as the core for the Ni3S2 shell. The as-prepared NiCo2O4@Ni3S2 nanowire array (NWA) electrodes exhibited excellent electrochemical performance, such as high specific areal capacitance and excellent cycling stability. The specific areal capacitance of 3.0 F cm-2 at a current density of 5 mA cm-2 is among the highest values and the only 6.7% capacitance decay after 10 000 cycles demonstrates the excellent cycling stability. A flexible asymmetric supercapacitor (ASC) was fabricated with activated carbon (AC) as the anode and the obtained NiCo2O4@Ni3S2 NWAs as the cathode. The ASC device exhibited a high energy density of 1.89 mW h cm-3 at 5.81 W cm-3 and a high power density of 56.33 W cm-3 at 0.94 mW h cm-3. As a result, the hybrid nanoarchitecture opens a new way to design high performance electrodes for electrochemical energy storage applications. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr02600a

  2. SRAM As An Array Of Energetic-Ion Detectors

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G.; Blaes, Brent R.; Lieneweg, Udo; Nixon, Robert H.

    1993-01-01

    Static random-access memory (SRAM) designed for use as array of energetic-ion detectors. Exploits well-known tendency of incident energetic ions to cause bit flips in cells of electronic memories. Design of ion-detector SRAM involves modifications of standard SRAM design to increase sensitivity to ions. Device fabricated by use of conventional complementary metal oxide/semiconductor (CMOS) processes. Potential uses include gas densimetry, position sensing, and measurement of cosmic-ray spectrum.

  3. In Situ Activation of 3D Porous Bi/Carbon Architectures: Toward High-Energy and Stable Nickel-Bismuth Batteries.

    PubMed

    Zeng, Yinxiang; Lin, Ziqi; Wang, Zifan; Wu, Mingmei; Tong, Yexiang; Lu, Xihong

    2018-05-01

    To achieve high-energy and stable aqueous rechargeable batteries, state-of-the art of anode materials are needed. Bismuth (Bi) has recently emerged as an attractive anode material due to its highly reversible redox reaction and suitable negative operating working window. However, the capacity and durability of currently reported Bi anodes are still far from satisfactory. Here, an in situ activation strategy is reported to prepare a 3D porous high-density Bi nanoparticles/carbon architecture (P-Bi-C) as an efficient anode for nickel-bismuth batteries. Taking advantages of the fast channels for charge transfer and ion diffusion, enhanced wettability, and accessible surface area, the highly loaded P-Bi-C electrode delivers a remarkable capacity of 2.11 mA h cm -2 as well as high rate capability (1.19 mA h cm -2 at 120 mA cm -2 ). To highlight, a robust aqueous rechargeable Ni//Bi battery based on the P-Bi-C anode is first constructed, achieving decent capacity (141 mA h g -1 ), impressive durability (94% capacity retention after 5000 cycles), and admirable energy density (16.9 mW h cm -3 ). This work paves the way for designing superfast nickel-bismuth batteries with high energy and long-life and may inspire new development for aqueous rechargeable batteries. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Microchannel cross load array with dense parallel input

    DOEpatents

    Swierkowski, Stefan P.

    2004-04-06

    An architecture or layout for microchannel arrays using T or Cross (+) loading for electrophoresis or other injection and separation chemistry that are performed in microfluidic configurations. This architecture enables a very dense layout of arrays of functionally identical shaped channels and it also solves the problem of simultaneously enabling efficient parallel shapes and biasing of the input wells, waste wells, and bias wells at the input end of the separation columns. One T load architecture uses circular holes with common rows, but not columns, which allows the flow paths for each channel to be identical in shape, using multiple mirror image pieces. Another T load architecture enables the access hole array to be formed on a biaxial, collinear grid suitable for EDM micromachining (square holes), with common rows and columns.

  5. Quantum many-body dynamics of strongly interacting atom arrays

    NASA Astrophysics Data System (ADS)

    Bernien, Hannes; Keesling, Alexander; Levine, Harry; Schwartz, Sylvain; Omran, Ahmed; Anschuetz, Eric; Endres, Manuel; Vuletic, Vladan; Greiner, Markus; Lukin, Mikhail

    2017-04-01

    The coherent interaction between large numbers of particles gives rise to fascinating quantum many-body effects and lies at the center of quantum simulations and quantum information processing. The development of systems consisting of many, well-controlled particles with tunable interactions is an outstanding challenge. Here we present a new platform based on large, reconfigurable arrays of individually trapped atoms. Strong interactions between these atoms are enabled by exciting them to Rydberg states. This flexible approach allows access to vastly different regimes with interactions tunable over several orders of magnitude. We study the coherent many-body dynamics in varying array geometries and observe the formation of Rydberg crystals.

  6. Molten carbonate fuel cell

    DOEpatents

    Kaun, Thomas D.; Smith, James L.

    1987-01-01

    A molten electrolyte fuel cell with an array of stacked cells and cell enclosures isolating each cell except for access to gas manifolds for the supply of fuel or oxidant gas or the removal of waste gas, the cell enclosures collectively providing an enclosure for the array and effectively avoiding the problems of electrolyte migration and the previous need for compression of stack components, the fuel cell further including an inner housing about and in cooperation with the array enclosure to provide a manifold system with isolated chambers for the supply and removal of gases. An external insulated housing about the inner housing provides thermal isolation to the cell components.

  7. Molten carbonate fuel cell

    DOEpatents

    Kaun, T.D.; Smith, J.L.

    1986-07-08

    A molten electrolyte fuel cell is disclosed with an array of stacked cells and cell enclosures isolating each cell except for access to gas manifolds for the supply of fuel or oxidant gas or the removal of waste gas. The cell enclosures collectively provide an enclosure for the array and effectively avoid the problems of electrolyte migration and the previous need for compression of stack components. The fuel cell further includes an inner housing about and in cooperation with the array enclosure to provide a manifold system with isolated chambers for the supply and removal of gases. An external insulated housing about the inner housing provides thermal isolation to the cell components.

  8. Record of Subducting Topography revealed in 3D Seismic Imaging of Pleistocene unconformities, offshore Southern Costa Rica

    NASA Astrophysics Data System (ADS)

    Edwards, J. H.; Kluesner, J. W.; Silver, E. A.

    2015-12-01

    3D seismic reflection data (CRISP) collected across the southern Costa Rica forearc reveals broad, survey-wide erosional events in the upper ~1 km of slope sediments in the mid-slope to outer shelf. The upper 0-280 m of continuous, weakly deformed sediments, designated by IODP Expedition 344 as structural domain I, is bounded by a major erosional event, (CRISP-U1, dated near 1 Ma), suggesting wave-plain erosion from the present shelf break out to 25 km seaward, to a present-day water depth of 900-1300 m. The eastern toe of its surface is characterized by a large drainage system, likely including submarine channels that eroded to depths >1500 m below present-day water depth. CRISP-U1 is variably uplifted by a series of fault propagation folds and cut by an intersecting array of normal faults. Another, major erosional event, (CRISP-M1, approximately 2 Ma) extended from the outer shelf to the mid slope and removed 500-1000 m of material. Overlying CRISP-M1 is up to 1 km of sediments that are more deformed by fault propagation folds, back thrusts, and intersecting arrays of normal faults. Unconformities with smaller areal extent are variably found in these overlying sediments across the mid-slope to outer shelf, at present-day water depths >220 m. Below CRISP-M1, sediments are more densely deformed and also contain major unconformities that extend survey-wide. Both unconformities, CRISP-U1 and CRISP-M1, are encountered in well U1413 and are demarcated by major benthic foraminifera assemblage changes at 149 mbsf and ~504 mbsf (Harris et al., 2013, Proceeding of the IODP, Volume 344).CRISP-M1 is likely correlative to the major sediment facies and benthic foraminifera assemblage change found in U1379 at ~880 mbsf (Vannuchi et al., 2013). The unconformities and intersecting array of normal faults may demarcate the passing of topography on the downgoing Cocos plate, episodically lifting and then subsiding the Costa Rica margin, with amplitudes up to about 1 km.

  9. Crustal and Upper Mantle Velocity Structure beneath Northwestern South America revealed by the CARMArray

    NASA Astrophysics Data System (ADS)

    Miao, W.; Cornthwaite, J.; Levander, A.; Niu, F.; Schmitz, M.; Dionicio, V.; Nader-Nieto, M. F.

    2017-12-01

    The Caribbean plate (CAR) is a fragment of the Farallon plate heavily modified by igneous processes that created the Caribbean large igneous province (CLIP) between 110 and 80 Ma.The CAR collided with and initiated subduction beneath northwestern South America plate (SA) at about 60-55 Ma as a narrow flat-slab subduction zone with an accretionary prism offshore, but no volcanic arc. Large scale regional tomography suggests that 1000 km of the CAR has been subducted (Van Benthem et al., 2013, JGR). The flat slab has caused Laramide-style basement uplifts of the Merida Andes, Sierra de la Perija, and Santa Marta ranges with elevations >5 km. The details of subduction geometry of the CAR plate beneath northeastern Colombia and northwestern Venezuela are complicated and remain unclear. The region of slab steepening lies below the triangular Maracaibo block (Bezada et al, 2010, JGR), bounded by major strike slip faults and currently escaping to the north over the CAR. Geodetic data suggests the this region has the potential for a magnitude 8+ earthquake (Bilham and Mencin, 2013, AGU Abstract). To better understand the subduction geometry, we deployed 65 broadband (BB) stations across northeastern Colombia and northwestern Venezuela in April of 2016. The 65 stations interweave with the 32 existing Colombian and Venezuelan BB stations, forming a 2-D array (hereafter referred to as CARMArray) with a station spacing of 35-100 km that covers an area of 600 km by 400 km extending from the Caribbean coast in Colombia to the interior plains of Venezuela. With data from the first year of operation, we have measured the Rayleigh wave phase velocities and Z/H ratios in the period range of 8-40 s using both ambient noise and earthquake data recorded by the CARMArray. We also generated Ps receiver functions from waveform data of teleseismic events recorded by the array. We then jointly inverted the three datasets to construct a 3-D S-wave velocity model beneath the array. We will report the initial results of the inversion and discuss the lateral variations of crustal and upper mantle structure and their potential links with surface geology and regional tectonics.

  10. Population structure and genome-wide association analysis for frost tolerance in oat using continuous SNP array signal intensity ratios.

    PubMed

    Tumino, Giorgio; Voorrips, Roeland E; Rizza, Fulvia; Badeck, Franz W; Morcia, Caterina; Ghizzoni, Roberta; Germeier, Christoph U; Paulo, Maria-João; Terzi, Valeria; Smulders, Marinus J M

    2016-09-01

    Infinium SNP data analysed as continuous intensity ratios enabled associating genotypic and phenotypic data from heterogeneous oat samples, showing that association mapping for frost tolerance is a feasible option. Oat is sensitive to freezing temperatures, which restricts the cultivation of fall-sown or winter oats to regions with milder winters. Fall-sown oats have a longer growth cycle, mature earlier, and have a higher productivity than spring-sown oats, therefore improving frost tolerance is an important goal in oat breeding. Our aim was to test the effectiveness of a Genome-Wide Association Study (GWAS) for mapping QTLs related to frost tolerance, using an approach that tolerates continuously distributed signals from SNPs in bulked samples from heterogeneous accessions. A collection of 138 European oat accessions, including landraces, old and modern varieties from 27 countries was genotyped using the Infinium 6K SNP array. The SNP data were analyzed as continuous intensity ratios, rather than converting them into discrete values by genotype calling. PCA and Ward's clustering of genetic similarities revealed the presence of two main groups of accessions, which roughly corresponded to Continental Europe and Mediterranean/Atlantic Europe, although a total of eight subgroups can be distinguished. The accessions were phenotyped for frost tolerance under controlled conditions by measuring fluorescence quantum yield of photosystem II after a freezing stress. GWAS were performed by a linear mixed model approach, comparing different corrections for population structure. All models detected three robust QTLs, two of which co-mapped with QTLs identified earlier in bi-parental mapping populations. The approach used in the present work shows that SNP array data of heterogeneous hexaploid oat samples can be successfully used to determine genetic similarities and to map associations to quantitative phenotypic traits.

  11. Highly catalytic and stabilized titanium nitride nanowire array-decorated graphite felt electrodes for all vanadium redox flow batteries

    NASA Astrophysics Data System (ADS)

    Wei, L.; Zhao, T. S.; Zeng, L.; Zeng, Y. K.; Jiang, H. R.

    2017-02-01

    In this work, we prepare a highly catalytic and stabilized titanium nitride (TiN) nanowire array-decorated graphite felt electrode for all vanadium redox flow batteries (VRFBs). Free-standing TiN nanowires are synthesized by a two-step process, in which TiO2 nanowires are first grown onto the surface of graphite felt via a seed-assisted hydrothermal method and then converted to TiN through nitridation reaction. When applied to VRFBs, the prepared electrode enables the electrolyte utilization and energy efficiency to be 73.9% and 77.4% at a high current density of 300 mA cm-2, which are correspondingly 43.3% and 15.4% higher than that of battery assembled with a pristine electrode. More impressively, the present battery exhibits good stability and high capacity retention during the cycle test. The superior performance is ascribed to the significant improvement in the electrochemical kinetics and enlarged active sites toward V3+/V2+ redox reaction.

  12. A short-pulse mode for the SPHINX LTD Z-pinch driver

    NASA Astrophysics Data System (ADS)

    D'Almeida, Thierry; Lassalle, Francis; Zucchini, Frederic; Loyen, Arnaud; Morell, Alain; Chuvatin, Alexander

    2015-11-01

    The SPHINX machine is a 6MA, 1 μs, LTD Z-pinch driver at CEA Gramat (France) and primarily used for studying radiation effects. Different power amplification concepts were examined in order to reduce the current rise time without modifying the generator discharge scheme, including the Dynamic Load Current Multiplier (DLCM) proposed by Chuvatin. A DLCM device, capable of shaping the current pulse without reducing the rise time, was developed at CEA. This device proved valuable for isentropic compression experiments in cylindrical geometry. Recently, we achieved a short pulse operation mode by inserting a vacuum closing switch between the DLCM and the load. The current rise time was reduced to ~300 ns. We explored the use of a reduced-height wire array for the Dynamic Flux Extruder in order to improve the wire array compression rate and increase the efficiency of the current transfer to the load. These developments are presented. Potential benefits of these developments for future Z pinch experiments are discussed.

  13. Co3 O4 Nanowire Arrays toward Superior Water Oxidation Electrocatalysis in Alkaline Media by Surface Amorphization.

    PubMed

    Zhou, Dan; He, Liangbo; Zhang, Rong; Hao, Shuai; Hou, Xiandeng; Liu, Zhiang; Du, Gu; Asiri, Abdullah M; Zheng, Chengbin; Sun, Xuping

    2017-11-07

    It is highly desirable to develop a simple, fast and straightforward method to boost the alkaline water oxidation of metal oxide catalysts. In this communication, we report our recent finding that the generation of amorphous Co-borate layer on Co 3 O 4 nanowire arrays supported on Ti mesh (Co 3 O 4 @Co-Bi NA/TM) leads to significantly boosted OER activity. The as-prepared Co 3 O 4 @Co-Bi NA/TM demands overpotential of 304 mV to drive a geometrical current density of 20 mA cm -2 in 1.0 M KOH, which is 109 mV less than that for Co 3 O 4 NA/TM, with its catalytic activity being preserved for at least 20 h. It suggests that the existence of amorphous Co-Bi layer promotes more CoO x (OH) y generation on Co 3 O 4 surface. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Radiation characteristics and implosion dynamics of Z-pinch dynamic hohlraums performed on PTS facility

    NASA Astrophysics Data System (ADS)

    Huang, Xian Bin; Ren, Xiao Dong; Dan, Jia Kun; Wang, Kun Lun; Xu, Qiang; Zhou, Shao Tong; Zhang, Si Qun; Cai, Hong Chun; Li, Jing; Wei, Bing; Ji, Ce; Feng, Shu Ping; Wang, Meng; Xie, Wei Ping; Deng, Jian Jun

    2017-09-01

    The preliminary experimental results of Z-pinch dynamic hohlraums conducted on the Primary Test Stand (PTS) facility are presented herein. Six different types of dynamic hohlraums were used in order to study the influence of load parameters on radiation characteristics and implosion dynamics, including dynamic hohlraums driven by single and nested arrays with different array parameters and different foams. The PTS facility can deliver a current of 6-8 MA in the peak current and 60-70 ns in the 10%-90% rising time to dynamic hohlraum loads. A set of diagnostics monitor the implosion dynamics of plasmas, the evolution of shock waves in the foam and the axial/radial X-ray radiation, giving the key parameters characterizing the features of dynamic hohlraums, such as the trajectory and related velocity of shock waves, radiation temperature, and so on. The experimental results presented here put our future study on Z-pinch dynamic hohlraums on the PTS facility on a firm basis.

  15. INDICATIONS OF INTERMEDIATE-SCALE ANISOTROPY OF COSMIC RAYS WITH ENERGY GREATER THAN 57 EeV IN THE NORTHERN SKY MEASURED WITH THE SURFACE DETECTOR OF THE TELESCOPE ARRAY EXPERIMENT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abbasi, R. U.; Abu-Zayyad, T.; Allen, M.

    2014-08-01

    We have searched for intermediate-scale anisotropy in the arrival directions of ultrahigh-energy cosmic rays with energies above 57 EeV in the northern sky using data collected over a 5 yr period by the surface detector of the Telescope Array experiment. We report on a cluster of events that we call the hotspot, found by oversampling using 20° radius circles. The hotspot has a Li-Ma statistical significance of 5.1σ, and is centered at R.A. = 146.°7, decl. = 43.°2. The position of the hotspot is about 19° off of the supergalactic plane. The probability of a cluster of events of 5.1σ significance, appearingmore » by chance in an isotropic cosmic-ray sky, is estimated to be 3.7 × 10{sup –4} (3.4σ)« less

  16. The Impact of Contextual Background Fusion on Perceived Value and Quality of Unclassified Terrorism Intelligence

    DTIC Science & Technology

    2007-03-01

    54 M . Fishbein and I . Ajzen , Belief, Attitude, Intention, and Behavior: An Introduction to Theory and Research. (MA: Addison-Wesley Reading...National Intelligence, 2006. http://www.fas.org/irp/dni/implement.pdf (accessed 9/9/2006). Fishbein , M ., and I . Ajzen . “Belief, Attitude...Advisor: Richard Bergin Second Reader: David Brannan THIS PAGE INTENTIONALLY LEFT BLANK i REPORT

  17. 75 FR 61096 - Regulated Navigation Area; Reserved Channel, Boston Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... transiting the RNA must do so at such a speed as to maintain bare steerage or not cause a wake. Vessels... the RNA to provide notice of the RNA as well as to control vessel speed, vessel access to the Reserved... will be enforced: (1) Vessels must transit through the RNA at such a speed as to not cause a wake or...

  18. Latin American women’s experiences with medical abortion in settings where abortion is legally restricted

    PubMed Central

    2012-01-01

    Abortion is legally restricted in most of Latin America where 95% of the 4.4 million abortions performed annually are unsafe. Medical abortion (MA) refers to the use of a drug or a combination of drugs to terminate pregnancy. Mifepristone followed by misoprostol is the most effective and recommended regime. In settings where mifepristone is not available, misoprostol alone is used. Medical abortion has radically changed abortion practices worldwide, and particularly in legally restricted contexts. In Latin America women have been using misoprostol for self-induced home abortions for over two decades. This article summarizes the findings of a literature review on women’s experiences with medical abortion in Latin American countries where voluntary abortion is illegal. Women’s personal experiences with medical abortion are diverse and vary according to context, age, reproductive history, social and educational level, knowledge about medical abortion, and the physical, emotional, and social circumstances linked to the pregnancy. But most importantly, experiences are determined by whether or not women have the chance to access: 1) a medically supervised abortion in a clandestine clinic or 2) complete and accurate information on medical abortion. Other key factors are access to economic resources and emotional support. Women value the safety and effectiveness of MA as well as the privacy that it allows and the possibility of having their partner, a friend or a person of their choice nearby during the process. Women perceive MA as less painful, easier, safer, more practical, less expensive, more natural and less traumatic than other abortion methods. The fact that it is self-induced and that it avoids surgery are also pointed out as advantages. Main disadvantages identified by women are that MA is painful and takes time to complete. Other negatively evaluated aspects have to do with side effects, prolonged bleeding, the possibility that it might not be effective, and the fact that some women eventually need to seek medical care at a hospital where they might be sanctioned for having an abortion and even reported to the police. PMID:23259660

  19. Magnetic filtration of phase separating ferrofluids: From basic concepts to microfluidic device

    NASA Astrophysics Data System (ADS)

    Kuzhir, P.; Magnet, C.; Ezzaier, H.; Zubarev, A.; Bossis, G.

    2017-06-01

    In this work, we briefly review magnetic separation of ferrofluids composed of large magnetic particles (60 nm of the average size) possessing an induced dipole moment. Such ferrofluids exhibit field-induced phase separation at relatively low particle concentrations (∼0.8 vol%) and magnetic fields (∼10 kA/m). Particle aggregates appearing during the phase separation are extracted from the suspending fluid by magnetic field gradients much easier than individual nanoparticles in the absence of phase separation. Nanoparticle capture by a single magnetized microbead and by multi-collector systems (packed bed of spheres and micro-pillar array) has been studied both experimentally and theoretically. Under flow and magnetic fields, the particle capture efficiency Λ decreases with an increasing Mason number for all considered geometries. This decrease may become stronger for aggregated magnetic particles (Λ ∝Ma-1.7) than for individual ones (Λ ∝Ma-1) if the shear fields are strong enough to provoke aggregate rupture. These results can be useful for development of new magneto-microfluidic immunoassays based on magnetic nanoparticles offering a much better sensitivity as compared to presently used magnetic microbeads.

  20. Middle Eocene rodents from Peruvian Amazonia reveal the pattern and timing of caviomorph origins and biogeography

    PubMed Central

    Antoine, Pierre-Olivier; Marivaux, Laurent; Croft, Darin A.; Billet, Guillaume; Ganerød, Morgan; Jaramillo, Carlos; Martin, Thomas; Orliac, Maëva J.; Tejada, Julia; Altamirano, Ali J.; Duranthon, Francis; Fanjat, Grégory; Rousse, Sonia; Gismondi, Rodolfo Salas

    2012-01-01

    The long-term isolation of South America during most of the Cenozoic produced a highly peculiar terrestrial vertebrate biota, with a wide array of mammal groups, among which caviomorph rodents and platyrrhine primates are Mid-Cenozoic immigrants. In the absence of indisputable pre-Oligocene South American rodents or primates, the mode, timing and biogeography of these extraordinary dispersals remained debated. Here, we describe South America's oldest known rodents, based on a new diverse caviomorph assemblage from the late Middle Eocene (approx. 41 Ma) of Peru, including five small rodents with three stem caviomorphs. Instead of being tied to the Eocene/Oligocene global cooling and drying episode (approx. 34 Ma), as previously considered, the arrival of caviomorphs and their initial radiation in South America probably occurred under much warmer and wetter conditions, around the Mid-Eocene Climatic Optimum. Our phylogenetic results reaffirm the African origin of South American rodents and support a trans-Atlantic dispersal of these mammals during Middle Eocene times. This discovery further extends the gap (approx. 15 Myr) between first appearances of rodents and primates in South America. PMID:21993503

  1. Fault-Tolerant Software-Defined Radio on Manycore

    NASA Technical Reports Server (NTRS)

    Ricketts, Scott

    2015-01-01

    Software-defined radio (SDR) platforms generally rely on field-programmable gate arrays (FPGAs) and digital signal processors (DSPs), but such architectures require significant software development. In addition, application demands for radiation mitigation and fault tolerance exacerbate programming challenges. MaXentric Technologies, LLC, has developed a manycore-based SDR technology that provides 100 times the throughput of conventional radiationhardened general purpose processors. Manycore systems (30-100 cores and beyond) have the potential to provide high processing performance at error rates that are equivalent to current space-deployed uniprocessor systems. MaXentric's innovation is a highly flexible radio, providing over-the-air reconfiguration; adaptability; and uninterrupted, real-time, multimode operation. The technology is also compliant with NASA's Space Telecommunications Radio System (STRS) architecture. In addition to its many uses within NASA communications, the SDR can also serve as a highly programmable research-stage prototyping device for new waveforms and other communications technologies. It can also support noncommunication codes on its multicore processor, collocated with the communications workload-reducing the size, weight, and power of the overall system by aggregating processing jobs to a single board computer.

  2. Radiation Effects of Commercial Resistive Random Access Memories

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; LaBel, Kenneth A.; Berg, Melanie; Wilcox, Edward; Kim, Hak; Phan, Anthony; Figueiredo, Marco; Buchner, Stephen; Khachatrian, Ani; Roche, Nicolas

    2014-01-01

    We present results for the single-event effect response of commercial production-level resistive random access memories. We found that the resistive memory arrays are immune to heavy ion-induced upsets. However, the devices were susceptible to single-event functional interrupts, due to upsets from the control circuits. The intrinsic radiation tolerant nature of resistive memory makes the technology an attractive consideration for future space applications.

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Braiman, Yehuda; Neschke, Brendan; Nair, Niketh S.

    Here, we study memory states of a circuit consisting of a small inductively coupled Josephson junction array and introduce basic (write, read, and reset) memory operations logics of the circuit. The presented memory operation paradigm is fundamentally different from conventional single quantum flux operation logics. We calculate stability diagrams of the zero-voltage states and outline memory states of the circuit. We also calculate access times and access energies for basic memory operations.

  4. Electrochemical pore filling strategy for controlled growth of magnetic and metallic nanowire arrays with large area uniformity

    NASA Astrophysics Data System (ADS)

    Arefpour, M.; Almasi Kashi, M.; Ramazani, A.; Montazer, A. H.

    2016-07-01

    While a variety of template-based strategies have been developed in the fabrication of nanowires (NWs), a uniform pore filling across the template still poses a major challenge. Here, we present a large area controlled pore filling strategy in the reproducible fabrication of various magnetic and metallic NW arrays, embedded inside anodic aluminum oxide templates. Using a diffusive pulsed electrodeposition (DPED) technique, this versatile strategy relies on the optimized filling of branched nanopores at the bottom of templates with Cu. Serving the Cu filled nanopores as appropriate nucleation sites, the DPED is followed by a uniform and homogeneous deposition of magnetic (Ni and Fe) and metallic (Cu and Zn) NWs at a current density of 50 mA cm-2 for an optimal thickness of alumina barrier layer (˜18 nm). Our strategy provides large area uniformity (exceeding 400 μm2) in the fabrication of 16 μm long free-standing NW arrays. Using hysteresis loop measurements and scanning electron microscopy images, the electrodeposition efficiency (EE) and pore filling percentage (F p) are evaluated, leading to maximum EE and F p values of 91% and 95% for Ni and Zn, respectively. Moreover, the resulting NW arrays are found to be highly crystalline. Accordingly, the DPED technique is capable of cheaply and efficiently controlling NW growth over a large area, providing a tool for various nanoscale applications including biomedical devices, electronics, photonics, magnetic storage medium and nanomagnet computing.

  5. Electrochemical pore filling strategy for controlled growth of magnetic and metallic nanowire arrays with large area uniformity.

    PubMed

    Arefpour, M; Kashi, M Almasi; Ramazani, A; Montazer, A H

    2016-06-01

    While a variety of template-based strategies have been developed in the fabrication of nanowires (NWs), a uniform pore filling across the template still poses a major challenge. Here, we present a large area controlled pore filling strategy in the reproducible fabrication of various magnetic and metallic NW arrays, embedded inside anodic aluminum oxide templates. Using a diffusive pulsed electrodeposition (DPED) technique, this versatile strategy relies on the optimized filling of branched nanopores at the bottom of templates with Cu. Serving the Cu filled nanopores as appropriate nucleation sites, the DPED is followed by a uniform and homogeneous deposition of magnetic (Ni and Fe) and metallic (Cu and Zn) NWs at a current density of 50 mA cm -2 for an optimal thickness of alumina barrier layer (∼18 nm). Our strategy provides large area uniformity (exceeding 400 μm 2 ) in the fabrication of 16 μm long free-standing NW arrays. Using hysteresis loop measurements and scanning electron microscopy images, the electrodeposition efficiency (EE) and pore filling percentage (F p ) are evaluated, leading to maximum EE and F p values of 91% and 95% for Ni and Zn, respectively. Moreover, the resulting NW arrays are found to be highly crystalline. Accordingly, the DPED technique is capable of cheaply and efficiently controlling NW growth over a large area, providing a tool for various nanoscale applications including biomedical devices, electronics, photonics, magnetic storage medium and nanomagnet computing.

  6. Solution-processed all-oxide bulk heterojunction solar cells based on CuO nanaorod array and TiO2 nanocrystals.

    PubMed

    Wu, Fan; Qiao, Qiquan; Bahrami, Behzad; Chen, Ke; Pathak, Rajesh; Tong, Yanhua; Li, Xiaoyi; Zhang, Tiansheng; Jian, Ronghua

    2018-05-25

    We present a method to synthesize CuO nanorod array/TiO 2 nanocrystals bulk heterojunction (BHJ) on fluorine-tin-oxide (FTO) glass, in which single-crystalline p-type semiconductor of the CuO nanorod array is grown on the FTO glass by hydrothermal reaction and the n-type semiconductor of the TiO 2 precursor is filled into the CuO nanorods to form well-organized nano-interpenetrating BHJ after air annealing. The interface charge transfer in CuO nanorod array/TiO 2 heterojunction is studied by Kelvin probe force microscopy (KPFM). KPFM results demonstrate that the CuO nanorod array/TiO 2 heterojunction can realize the transfer of photo-generated electrons from the CuO nanorod array to TiO 2 . In this work, a solar cell with the structure FTO/CuO nanoarray/TiO 2 /Al is successfully fabricated, which exhibits an open-circuit voltage (V oc ) of 0.20 V and short-circuit current density (J sc ) of 0.026 mA cm -2 under AM 1.5 illumination. KPFM studies indicate that the very low performance is caused by an undesirable interface charge transfer. The interfacial surface potential (SP) shows that the electron concentration in the CuO nanorod array changes considerably after illumination due to increased photo-generated electrons, but the change in the electron concentration in TiO 2 is much less than in CuO, which indicates that the injection efficiency of the photo-generated electrons from CuO to TiO 2 is not satisfactory, resulting in an undesirable J sc in the solar cell. The interface photovoltage from the KPFM measurement shows that the low V oc results from the small interfacial SP difference between CuO and TiO 2 because the low injected electron concentration cannot raise the Fermi level significantly in TiO 2 . This conclusion agrees with the measured work function results under illumination. Hence, improvement of the interfacial electron injection is primary for the CuO nanorod array/TiO 2 heterojunction solar cells.

  7. Solution-processed all-oxide bulk heterojunction solar cells based on CuO nanaorod array and TiO2 nanocrystals

    NASA Astrophysics Data System (ADS)

    Wu, Fan; Qiao, Qiquan; Bahrami, Behzad; Chen, Ke; Pathak, Rajesh; Tong, Yanhua; Li, Xiaoyi; Zhang, Tiansheng; Jian, Ronghua

    2018-05-01

    We present a method to synthesize CuO nanorod array/TiO2 nanocrystals bulk heterojunction (BHJ) on fluorine-tin-oxide (FTO) glass, in which single-crystalline p-type semiconductor of the CuO nanorod array is grown on the FTO glass by hydrothermal reaction and the n-type semiconductor of the TiO2 precursor is filled into the CuO nanorods to form well-organized nano-interpenetrating BHJ after air annealing. The interface charge transfer in CuO nanorod array/TiO2 heterojunction is studied by Kelvin probe force microscopy (KPFM). KPFM results demonstrate that the CuO nanorod array/TiO2 heterojunction can realize the transfer of photo-generated electrons from the CuO nanorod array to TiO2. In this work, a solar cell with the structure FTO/CuO nanoarray/TiO2/Al is successfully fabricated, which exhibits an open-circuit voltage (V oc) of 0.20 V and short-circuit current density (J sc) of 0.026 mA cm‑2 under AM 1.5 illumination. KPFM studies indicate that the very low performance is caused by an undesirable interface charge transfer. The interfacial surface potential (SP) shows that the electron concentration in the CuO nanorod array changes considerably after illumination due to increased photo-generated electrons, but the change in the electron concentration in TiO2 is much less than in CuO, which indicates that the injection efficiency of the photo-generated electrons from CuO to TiO2 is not satisfactory, resulting in an undesirable J sc in the solar cell. The interface photovoltage from the KPFM measurement shows that the low V oc results from the small interfacial SP difference between CuO and TiO2 because the low injected electron concentration cannot raise the Fermi level significantly in TiO2. This conclusion agrees with the measured work function results under illumination. Hence, improvement of the interfacial electron injection is primary for the CuO nanorod array/TiO2 heterojunction solar cells.

  8. Seismic perspectives from the western U.S. on the evolution of magma reservoirs underlying major silicic eruptions

    NASA Astrophysics Data System (ADS)

    Schmandt, B.; Huang, H. H.; Farrell, J.; Hansen, S. M.; Jiang, C.

    2017-12-01

    The western U.S. Cordillera has hosted widespread magmatic activity since the Eocene including ≥1,000 km3 silicic eruptions since 1 Ma. A review of recent seismic constraints on relatively young (≤1.1 Ma) and old (Oligocene) magmatic systems provides insight into the heterogeneity among these systems and their temporal evolution. Local seismic data vary widely but all of these systems are covered by the USArray's 70-km spacing. Among 3 young systems with ≥300 km3 silicic eruptions (Yellowstone - 0.64 Ma; Long Valley - 0.76 Ma; Valles - 1.1 Ma) only Yellowstone shows sufficiently low seismic velocities to require partial melt in the upper crust at scales visible with USArray data. Finer-scale arrays refine the shape of large (>1,000 km3) partially molten volumes in the upper and lower crust at Yellowstone, and similar studies at Long Valley and Valles indicate much smaller volumes of partial melt. Notably, Long Valley Caldera is seismically active in the upper and lower crust, has a high flux of CO2 degassing, and multi-year geodetic transients consistent with an inflating upper crustal reservoir of 2-4 km radius (compared to 20x50x5 km at Yellowstone). Upper mantle seismic imaging finds strong low velocity anomalies that require some partial melt beneath Yellowstone and Long Valley, but more ambiguous results beneath Valles. Thus, the structures of the three young large-volume silicic systems are highly variable suggesting that large reservoirs of melt in the upper crust are short-lived with respect to the ≤1.1 Ma since the last major eruption, consistent with recent inferences from geochemically constrained thermal histories of erupted crystals. Among long-extinct silicic systems, most were severely overprinted by extensional deformation. The San Juan and Mogollon Datil are exceptions with only modest deformation. These systems show low-to-average velocity crust down to a sharp Moho and relatively thin crust for their elevations. Both are consistent with a felsic to intermediate crustal column, suggesting that mafic cumulates required to produce silicic magma from basaltic inputs are not present in large quantities (>5 km layers). We infer that post-eruption foundering of mafic cumulates into the mantle occurred and was not followed by another major episode of basaltic melt input.

  9. Anomalous Alkali-Olivine Basalts Associated with Arc-related Late Cenozoic Volcanism in Southern Hispaniola

    NASA Astrophysics Data System (ADS)

    Lewis, J.; Perfit, M. R.; Kamenov, G.

    2006-12-01

    Several eruptive centers of Pliocene-Quaternary age occur across southern Hispaniola that constitutes the youngest land-based magmatic activity in the Greater Antilles. Two main rock suites can be delineated based on petrography, geochemistry and location. The older larger centers in the Dominican Republic (DR) consist of basalts (45.81-53% SiO2 with TiO2 <1.2%), basaltic andesites and trachybasalts (54-55% SiO2) and trachyandesites (56-62% SiO2). These constitute a consanguineous high-K calc-alkaline (CA) series. Younger centers of Quaternary age (all probably < 1.0 Ma) occur to the west in Haiti, at San Juan de la Maguana (DR) and two small centers to the south of Yayas de Viajama (DR). The rocks are alkali-olivine basalts, limburgites and nephelenites (38.6-47.6% SiO2 with TiO2 >1.7 at MgO<12%) and are termed the mafic alkaline (MA) series. Although there is an overall similarity in the trace and minor element patterns of normalized multi-element plots of the rocks samples the CA series shows distinct depletions in the HFS elements Ta, Nb, Hf, Zr, and Ti compared to lavas in the MA series. MA series samples exhibit strong enrichment in LREE (Ce/Ybn = > 30) compared to the CA series basalts (Ce/Ybn = < 30) and greater HREE depletions. The CA suite has higher 143Nd/144Nd (0.51286 ? 0.5126) and lower 87Sr/86Sr (0.7040 ? 0.7053) than the MA suite (0.5126-0.51196; 0.7063- 0.7078). MA series lavas have unusually non-radiogenic Pb isotopic values (206Pb/204Pb < 17.9) whereas the CA suite has low but values more typical of the Greater Antilles. Incompatible trace element ratios such as Ba/Nb, Sr/Nd, Ce/Yb and Ba/La are well correlated with isotopes but the data form near continuous arrays suggesting mixing between sources. The data suggest the young alkaline lavas are derived from enriched mantle source similar to EM1 but that they are also mixing with a component reflected in the composition of the CA series that is related to previous subduction- related enrichment of the sub-arc mantle beneath Hispaniola. The presence of an EM1 component in the Greater Antilles has not been previously recognized and is unusual for an arc environment.

  10. Development and preliminary evaluation of a 90 K Axiom® SNP array for the allo-octoploid cultivated strawberry Fragaria × ananassa.

    PubMed

    Bassil, Nahla V; Davis, Thomas M; Zhang, Hailong; Ficklin, Stephen; Mittmann, Mike; Webster, Teresa; Mahoney, Lise; Wood, David; Alperin, Elisabeth S; Rosyara, Umesh R; Koehorst-Vanc Putten, Herma; Monfort, Amparo; Sargent, Daniel J; Amaya, Iraida; Denoyes, Beatrice; Bianco, Luca; van Dijk, Thijs; Pirani, Ali; Iezzoni, Amy; Main, Dorrie; Peace, Cameron; Yang, Yilong; Whitaker, Vance; Verma, Sujeet; Bellon, Laurent; Brew, Fiona; Herrera, Raul; van de Weg, Eric

    2015-03-07

    A high-throughput genotyping platform is needed to enable marker-assisted breeding in the allo-octoploid cultivated strawberry Fragaria × ananassa. Short-read sequences from one diploid and 19 octoploid accessions were aligned to the diploid Fragaria vesca 'Hawaii 4' reference genome to identify single nucleotide polymorphisms (SNPs) and indels for incorporation into a 90 K Affymetrix® Axiom® array. We report the development and preliminary evaluation of this array. About 36 million sequence variants were identified in a 19 member, octoploid germplasm panel. Strategies and filtering pipelines were developed to identify and incorporate markers of several types: di-allelic SNPs (66.6%), multi-allelic SNPs (1.8%), indels (10.1%), and ploidy-reducing "haploSNPs" (11.7%). The remaining SNPs included those discovered in the diploid progenitor F. iinumae (3.9%), and speculative "codon-based" SNPs (5.9%). In genotyping 306 octoploid accessions, SNPs were assigned to six classes with Affymetrix's "SNPolisher" R package. The highest quality classes, PolyHigh Resolution (PHR), No Minor Homozygote (NMH), and Off-Target Variant (OTV) comprised 25%, 38%, and 1% of array markers, respectively. These markers were suitable for genetic studies as demonstrated in the full-sib family 'Holiday' × 'Korona' with the generation of a genetic linkage map consisting of 6,594 PHR SNPs evenly distributed across 28 chromosomes with an average density of approximately one marker per 0.5 cM, thus exceeding our goal of one marker per cM. The Affymetrix IStraw90 Axiom array is the first high-throughput genotyping platform for cultivated strawberry and is commercially available to the worldwide scientific community. The array's high success rate is likely driven by the presence of naturally occurring variation in ploidy level within the nominally octoploid genome, and by effectiveness of the employed array design and ploidy-reducing strategies. This array enables genetic analyses including generation of high-density linkage maps, identification of quantitative trait loci for economically important traits, and genome-wide association studies, thus providing a basis for marker-assisted breeding in this high value crop.

  11. Interseismic strain and rotation rates in the northeast Mojave domain, eastern California

    USGS Publications Warehouse

    Savage, J.C.; Svarc, J.L.; Prescott, II W.

    2004-01-01

    The northeast Mojave domain, a type locality for bookshelf faulting, is a region of east striking, left-lateral faults in the northeast comer of the Mojave block, a block otherwise dominated by ??N40??W striking, right-lateral faults. Paleomagnetic evidence suggests that blocks within the domain have rotated clockwise about a vertical axis as much as 60?? since 12.8 Ma [Schermer et al., 1996]. In 1994, and again in 2002, the U.S. Geological Survey surveyed an array of 14 geodetic monuments distributed across the northeast Mojave domain. The 2002 survey results were adjusted to remove the coseismic offsets imposed by the nearby Hector Mine earthquake (16 October 1999, Mw = 7.1). The adjusted deformation across the array appears to be uniform and can be approximated by the principal strain rates ??:1 = 28.9 ?? 9.1 N77.2??W ?? 4.8?? and ??2 = -48.2 ?? 8.9 N12.8??E ?? 4.8?? nstrain yr-1; extension reckoned positive, and quoted uncertainties are standard deviations. That strain accumulation could be released by slip . on faults striking N32??W but not by bookshelf faulting on the east striking faults alone. The vertical axis rotation rate of the northeast Mojave domain as a whole relative to fixed North America is 71.0 ?? 6.4 nrad yr-1 (4.07?? ?? 0.37?? Myr-1) clockwise, about twice the maximum tenser shear strain rate. The observed rotation rate acting over 12.8 Myr would produce'a clockwise rotation of 52.1?? ?? 4.7??, exclusive of possible coseismic rotations. That rotation is in rough agreement with the paleomagnetic rotation accumulated in the individual fault blocks within the northeast Mojave domain since 12.8 Ma.

  12. Natural Convection Immersion Cooling of an Array of Heated Protrusions in an Enclosure Filled with Dielectric Liquid: Effects of Enclosure Width and Fluid Prandtl Number

    DTIC Science & Technology

    1991-03-01

    ELEMENT NO. NO. NO. ACCESSION NO ’ A~rIECti fvMERSlON COOLING OF AN ARRAY OF HEATED PROTRUSIONS IN AN ENCLOSURE FILLED WITH DIELECTRIC LIQUID...341 10. SS7 6.779 S.S1S TEMP.BASED RAYLEIGH NUMBER - E-B IS: 2.13 FLUX BASED RAYLEIGH NUMBER - E-6 IS: 14.42 AVERAGE TEMPERATURE: 20.987 SINK TEMPERATURE

  13. An Improved Zero Potential Circuit for Readout of a Two-Dimensional Resistive Sensor Array

    PubMed Central

    Wu, Jian-Feng; Wang, Feng; Wang, Qi; Li, Jian-Qing; Song, Ai-Guo

    2016-01-01

    With one operational amplifier (op-amp) in negative feedback, the traditional zero potential circuit could access one element in the two-dimensional (2-D) resistive sensor array with the shared row-column fashion but it suffered from the crosstalk problem for the non-scanned elements’ bypass currents, which were injected into array’s non-scanned electrodes from zero potential. Firstly, for suppressing the crosstalk problem, we designed a novel improved zero potential circuit with one more op-amp in negative feedback to sample the total bypass current and calculate the precision resistance of the element being tested (EBT) with it. The improved setting non-scanned-electrode zero potential circuit (S-NSE-ZPC) was given as an example for analyzing and verifying the performance of the improved zero potential circuit. Secondly, in the S-NSE-ZPC and the improved S-NSE-ZPC, the effects of different parameters of the resistive sensor arrays and their readout circuits on the EBT’s measurement accuracy were simulated with the NI Multisim 12. Thirdly, part features of the improved circuit were verified with the experiments of a prototype circuit. Followed, the results were discussed and the conclusions were given. The experiment results show that the improved circuit, though it requires one more op-amp, one more resistor and one more sampling channel, can access the EBT in the 2-D resistive sensor array more accurately. PMID:27929410

  14. BioMaS: a modular pipeline for Bioinformatic analysis of Metagenomic AmpliconS.

    PubMed

    Fosso, Bruno; Santamaria, Monica; Marzano, Marinella; Alonso-Alemany, Daniel; Valiente, Gabriel; Donvito, Giacinto; Monaco, Alfonso; Notarangelo, Pasquale; Pesole, Graziano

    2015-07-01

    Substantial advances in microbiology, molecular evolution and biodiversity have been carried out in recent years thanks to Metagenomics, which allows to unveil the composition and functions of mixed microbial communities in any environmental niche. If the investigation is aimed only at the microbiome taxonomic structure, a target-based metagenomic approach, here also referred as Meta-barcoding, is generally applied. This approach commonly involves the selective amplification of a species-specific genetic marker (DNA meta-barcode) in the whole taxonomic range of interest and the exploration of its taxon-related variants through High-Throughput Sequencing (HTS) technologies. The accessibility to proper computational systems for the large-scale bioinformatic analysis of HTS data represents, currently, one of the major challenges in advanced Meta-barcoding projects. BioMaS (Bioinformatic analysis of Metagenomic AmpliconS) is a new bioinformatic pipeline designed to support biomolecular researchers involved in taxonomic studies of environmental microbial communities by a completely automated workflow, comprehensive of all the fundamental steps, from raw sequence data upload and cleaning to final taxonomic identification, that are absolutely required in an appropriately designed Meta-barcoding HTS-based experiment. In its current version, BioMaS allows the analysis of both bacterial and fungal environments starting directly from the raw sequencing data from either Roche 454 or Illumina HTS platforms, following two alternative paths, respectively. BioMaS is implemented into a public web service available at https://recasgateway.ba.infn.it/ and is also available in Galaxy at http://galaxy.cloud.ba.infn.it:8080 (only for Illumina data). BioMaS is a friendly pipeline for Meta-barcoding HTS data analysis specifically designed for users without particular computing skills. A comparative benchmark, carried out by using a simulated dataset suitably designed to broadly represent the currently known bacterial and fungal world, showed that BioMaS outperforms QIIME and MOTHUR in terms of extent and accuracy of deep taxonomic sequence assignments.

  15. Radiation damage-He diffusivity models applied to deep-time thermochronology: Zircon and titanite (U-Th)/He datasets from cratonic settings

    NASA Astrophysics Data System (ADS)

    Guenthner, W.; DeLucia, M. S.; Marshak, S.; Reiners, P. W.; Drake, H.; Thomson, S.; Ault, A. K.; Tillberg, M.

    2017-12-01

    Advances in understanding the effects of radiation damage on He diffusion in uranium-bearing accessory minerals have shown the utility of damage-diffusivity models for interpreting datasets from geologic settings with long-term, low-temperature thermal histories. Craton interiors preserve a billion-year record of long-term, long-wavelength vertical motions of the lithosphere. Prior thermochronologic work in these settings has focused on radiation damage models used in conjunction with apatite (U-Th)/He dates to constrain Phanerozoic thermal histories. Owing to the more complex damage-diffusivity relationship in zircon, the zircon (U-Th)/He system yields both higher and, in some cases, lower temperature sensitivities than the apatite system, and this greater range in turn allows researchers to access deeper time (i.e., Proterozoic) segments of craton time-temperature histories. Here, we show two examples of this approach by focusing on zircon (U-Th)/He datasets from 1.8 Ga granitoids of the Fennoscandian Shield in southeastern Sweden, and 1.4 Ga granites and rhyolites of the Ozark Plateau in southeastern Missouri. In the Ozark dataset, the zircon (U-Th)/He data, combined with a damage-diffusivity model, predict negative correlations between date and effective uranium (eU) concentration (a measurement proportional to radiation damage) from thermal histories that include an episode of Proterozoic cooling (interpreted as exhumation) following reheating (interpreted as burial) to temperature of 260°C at 850-680 Ma. In the Fennoscandian Shield, a similar damage model-based approach yields time-temperature constraints with burial to 217°C between 944 Ma and 851 Ma, followed by exhumation from 850 to 500 Ma, and burial to 154°C between 366 Ma and 224 Ma. Our Fennoscandian Shield samples also include titanite (U-Th)/He dates that span a wide range (945-160 Ma) and are negatively correlated with eU concentration, analogous to our zircon He dataset. These results support the initial findings of Baughman et al. (2017, Tectonics), and suggest that further research into the radiation damage effect on He diffusion in titanite could yield a comprehensive damage-diffusivity model for the titanite (U-Th)/He thermochronometer.

  16. MaGa, a web-based collaborative database for gas emissions: a tool to improve the knowledge on Earth degassing

    NASA Astrophysics Data System (ADS)

    Frigeri, A.; Cardellini, C.; Chiodini, G.; Frondini, F.; Bagnato, E.; Aiuppa, A.; Fischer, T. P.; Lehnert, K. A.

    2014-12-01

    The study of the main pathways of carbon flux from the deep Earth requires the analysis of a large quantity and variety of data on volcanic and non-volcanic gas emissions. Hence, there is need for common frameworks to aggregate available data and insert new observations. Since 2010 we have been developing the Mapping Gas emissions (MaGa) web-based database to collect data on carbon degassing form volcanic and non-volcanic environments. MaGa uses an Object-relational model, translating the experience of field surveyors into the database schema. The current web interface of MaGa allows users to browse the data in tabular format or by browsing an interactive web-map. Enabled users can insert information as measurement methods, instrument details as well as the actual values collected in the field. Measurements found in the literature can be inserted as well as direct field observations made by human-operated instruments. Currently the database includes fluxes and gas compositions from active craters degassing, diffuse soil degassing and fumaroles both from dormant volcanoes and open-vent volcanoes from literature survey and data about non-volcanic emission of the Italian territory. Currently, MaGa holds more than 1000 volcanic plume degassing fluxes, data from 30 sites of diffuse soil degassing from italian volcanoes, and about 60 measurements from fumarolic and non volcanic emission sites. For each gas emission site, the MaGa holds data, pictures, descriptions on gas sampling, analysis and measurement methods, together with bibliographic references and contacts to researchers having experience on each site. From 2012, MaGa developments started to be focused towards the framework of the Deep Earth Carbon Degassing research initiative of the Deep Carbon Observatory. Whithin the DECADE initiative, there are others data systems, as EarthChem and the Smithsonian Institution's Global Volcanism Program. An interoperable interaction between the DECADE data systems is being planned. MaGa is showing good potentials to improve the knowledge on Earth degassing firstly by making data more accessible and encouraging participation among researchers, and secondly by allowing to observe and explore, for the first time, a gas emission dataset with spatial and temporal extents never analyzed before.

  17. Use of microsecond current prepulse for dramatic improvements of wire array Z-pinch implosion

    NASA Astrophysics Data System (ADS)

    Calamy, H.; Lassalle, F.; Loyen, A.; Zucchini, F.; Chittenden, J. P.; Hamann, F.; Maury, P.; Georges, A.; Bedoch, J. P.; Morell, A.

    2008-01-01

    The Sphinx machine [F. Lassalle et al., "Status on the SPHINX machine based on the 1microsecond LTD technology"] based on microsecond linear transformer driver (LTD) technology is used to implode an aluminium wire array with an outer diameter up to 140mm and maximum current from 3.5to5MA. 700to800ns implosion Z-pinch experiments are performed on this driver essentially with aluminium. Best results obtained before the improvement described in this paper were 1-3TW radial total power, 100-300kJ total yield, and 20-30kJ energy above 1keV. An auxiliary generator was added to the Sphinx machine in order to allow a multi microsecond current to be injected through the wire array load before the start of the main current. Amplitude and duration of this current prepulse are adjustable, with maxima ˜10kA and 50μs. This prepulse dramatically changes the ablation phase leading to an improvement of the axial homogeneity of both the implosion and the final radiating column. Total power was multiplied by a factor of 6, total yield by a factor of 2.5 with a reproducible behavior. This paper presents experimental results, magnetohydrodynamic simulations, and analysis of the effect of such a long current prepulse.

  18. Ni nanotube array-based electrodes by electrochemical alloying and de-alloying for efficient water splitting.

    PubMed

    Teng, Xue; Wang, Jianying; Ji, Lvlv; Lv, Yaokang; Chen, Zuofeng

    2018-05-17

    The design of cost-efficient earth-abundant catalysts with superior performance for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is extremely important for future renewable energy production. Herein, we report a facile strategy for constructing Ni nanotube arrays (NTAs) on a Ni foam (NF) substrate through cathodic deposition of NiCu alloy followed by anodic stripping of metallic Cu. Based on Ni NTAs, the as-prepared NiSe2 NTA electrode by NiSe2 electrodeposition and the NiFeOx NTA electrode by dipping in Fe3+ solution exhibit excellent HER and OER performance in alkaline conditions. In these systems, Ni NTAs act as a binder-free multifunctional inner layer to support the electrocatalysts, offer a large specific surface area and serve as a fast electron transport pathway. Moreover, an alkaline electrolyzer has been constructed using NiFeOx NTAs as the anode and NiSe2 NTAs as the cathode, which only demands a cell voltage of 1.78 V to deliver a water-splitting current density of 500 mA cm-2, and demonstrates remarkable stability during long-term electrolysis. This work provides an attractive method for the design and fabrication of nanotube array-based catalyst electrodes for highly efficient water-splitting.

  19. Diagnostics for Z-pinch implosion experiments on PTS

    NASA Astrophysics Data System (ADS)

    Ren, X. D.; Huang, X. B.; Zhou, S. T.; Zhang, S. Q.; Dan, J. K.; Li, J.; Cai, H. C.; Wang, K. L.; Ouyang, K.; Xu, Q.; Duan, S. C.; Chen, G. H.; Wang, M.; Feng, S. P.; Yang, L. B.; Xie, W. P.; Deng, J. J.

    2014-12-01

    The preliminary experiments of wire array implosion were performed on PTS, a 10 MA z-pinch driver with a 70 ns rise time. A set of diagnostics have been developed and fielded on PTS to study pinch physics and implosion dynamics of wire array. Radiated power measurement for soft x-rays was performed by multichannel filtered x-ray diode array, and flat spectral responses x-ray diode detector. Total x-ray yield was measured by a calibrated, unfiltered nickel bolometer which was also used to obtain pinch power. Multiple time-gated pinhole cameras were used to produce spatial-resolved images of x-ray self-emission from plasmas. Two time-integrated pinhole cameras were used respectively with 20-μm Be filter and with multilayer mirrors to record images produced by >1-keV and 277±5 eV self-emission. An optical streak camera was used to produce radial implosion trajectories, and an x-ray streak camera paired with a horizontal slit was used to record a continuous time-history of emission with one-dimensional spatial resolution. A frequency-doubled Nd:YAG laser (532 nm) was used to produce four frame laser shadowgraph images with 6 ns time interval. We will briefly describe each of these diagnostics and present some typical results from them.

  20. Fast electrosynthesis of Fe-containing layered double hydroxide arrays toward highly efficient electrocatalytic oxidation reactions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02417j

    PubMed Central

    Li, Zhenhua; An, Hongli; Wang, Zixuan; Xu, Simin; Evans, David G.; Duan, Xue

    2015-01-01

    A new electrochemical synthesis route was developed for the fabrication of Fe-containing layered double hydroxide (MFe-LDHs, M = Ni, Co and Li) hierarchical nanoarrays, which exhibit highly-efficient electrocatalytic performances for the oxidation reactions of several small molecules (water, hydrazine, methanol and ethanol). Ultrathin MFe-LDH nanoplatelets (200–300 nm in lateral length; 8–12 nm in thickness) perpendicular to the substrate surface are directly prepared within hundreds of seconds (<300 s) under cathodic potential. The as-obtained NiFe-LDH nanoplatelet arrays display promising behavior in the oxygen evolution reaction (OER), giving rise to a rather low overpotential (0.224 V) at 10.0 mA cm–2 with largely enhanced stability, much superior to previously reported electro-oxidation catalysts as well as the state-of-the-art Ir/C catalyst. Furthermore, the MFe-LDH nanoplatelet arrays can also efficiently catalyze several other fuel molecules’ oxidation (e.g., hydrazine, methanol and ethanol), delivering a satisfactory electrocatalytic activity and a high operation stability. In particular, this preparation method of Fe-containing LDHs is amenable to fast, effective and large-scale production, and shows promising applications in water splitting, fuel cells and other clean energy devices. PMID:29435211

  1. Evolutionary multidimensional access architecture featuring cost-reduced components

    NASA Astrophysics Data System (ADS)

    Farjady, Farsheed; Parker, Michael C.; Walker, Stuart D.

    1998-12-01

    We describe a three-stage wavelength-routed optical access network, utilizing coarse passband-flattened arrayed- waveguide grating routers. An N-dimensional addressing strategy enables 6912 customers to be bi-directionally addressed with multi-Gb/s data using only 24 wavelengths spaced by 1.6 nm. Coarse wavelength separation allows use of increased tolerance WDM components at the exchange and customer premises. The architecture is designed to map onto standard access network topologies, allowing elegant upgradability from legacy PON infrastructures at low cost. Passband-flattening of the routers is achieved through phase apodization.

  2. AxBAxB… pulsed atomic layer deposition: Numerical growth model and experiments

    NASA Astrophysics Data System (ADS)

    Muneshwar, Triratna; Cadien, Ken

    2016-02-01

    Atomic layer deposition (ALD) is widely used for the fabrication of advanced semiconductor devices and related nanoscale structures. During ALD, large precursor doses (>1000 L per pulse) are often required to achieve surface saturation, of which only a small fraction is utilized in film growth while the rest is pumped from the system. Since the metal precursor constitutes a significant cost of ALD, strategies to enhance precursor utilization are essential for the scaling of ALD processes. In the precursor reaction step, precursor physisorption is restricted by steric hindrance (mA1) from ligands on the precursor molecules. On reaction, some of these ligands are removed as by-products resulting in chemisorbed species with reduced steric hindrance (mA1 → mA2, where mA2 < mA1) and some of the initially hindered surface reaction sites becoming accessible for further precursor physisorption. To utilize these additional reaction sites, we propose a generalized AxBAxB… pulsed deposition where the total precursor dose (ΦA) is introduced as multiple x (x > 1, x ∈ I) short-pulses rather than a single pulse. A numerical first-order surface reaction kinetics growth model is presented and applied to study the effect of AxBAxB… pulsed ALD on the growth per cycle (GPC). The model calculations predict higher GPC for AxBAxB… pulsing than with ABAB… deposition. In agreement with the model predictions, with AxBAxB… pulsed deposition, the GPC was found to increase by ˜46% for ZrN plasma enhanced ALD (PEALD), ˜49% for HfO2 PEALD, and ˜8% for thermal Al2O3 ALD with respect to conventional ABAB… pulsed growth.

  3. Development and testing of a new framework for rapidly assessing legal and managerial protection afforded by marine protected areas: Mediterranean Sea case study.

    PubMed

    Rodríguez-Rodríguez, D; Rodríguez, J; Abdul Malak, D

    2016-02-01

    The Convention on Biological Diversity (CBD) states the need to effectively conserve at least 10% of coastal and marine areas of particular importance for biodiversity by 2020. Here, a new indicator-based methodological framework to assess biodiversity protection afforded by marine protected areas' (MPA) was developed as a quick surrogate for MPAs' potential conservation effectiveness: the Marine Protected Area Protection Assessment Framework (MaPAF). The MaPAF consists of a limited number of headline indicators that are integrated in two indexes: Legal protection and Management effort, which eventually integrate in the overall MPA Protection super-index. The MaPAF was then tested in the Mediterranean MPA network as a case study. Spatial analyses were performed at three meaningful scales: the whole Mediterranean Sea, Mediterranean ecoregions and countries. The results of this study suggest that: 1) The MaPAF can serve as a useful tool for consistent, adaptive, quick and cost-effective MPA effectiveness assessments of MPAs and MPA networks in virtually any marine region, as the headline indicators used are commonly compiled and easy to retrieve; 2) The MaPAF proved usable and potentially relevant in the Mediterranean Sea where most indicators in the framework can be publicly accessed through the MAPAMED database and are planned to be regularly updated; 3) Protection afforded by MPAs is low across the whole Mediterranean, with only few MPAs having relatively high legal and managerial protection; and 4) Most Mediterranean countries need to devote substantially more work to improve MPA effectiveness mainly through increased management effort. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. A scalable moment-closure approximation for large-scale biochemical reaction networks

    PubMed Central

    Kazeroonian, Atefeh; Theis, Fabian J.; Hasenauer, Jan

    2017-01-01

    Abstract Motivation: Stochastic molecular processes are a leading cause of cell-to-cell variability. Their dynamics are often described by continuous-time discrete-state Markov chains and simulated using stochastic simulation algorithms. As these stochastic simulations are computationally demanding, ordinary differential equation models for the dynamics of the statistical moments have been developed. The number of state variables of these approximating models, however, grows at least quadratically with the number of biochemical species. This limits their application to small- and medium-sized processes. Results: In this article, we present a scalable moment-closure approximation (sMA) for the simulation of statistical moments of large-scale stochastic processes. The sMA exploits the structure of the biochemical reaction network to reduce the covariance matrix. We prove that sMA yields approximating models whose number of state variables depends predominantly on local properties, i.e. the average node degree of the reaction network, instead of the overall network size. The resulting complexity reduction is assessed by studying a range of medium- and large-scale biochemical reaction networks. To evaluate the approximation accuracy and the improvement in computational efficiency, we study models for JAK2/STAT5 signalling and NFκB signalling. Our method is applicable to generic biochemical reaction networks and we provide an implementation, including an SBML interface, which renders the sMA easily accessible. Availability and implementation: The sMA is implemented in the open-source MATLAB toolbox CERENA and is available from https://github.com/CERENADevelopers/CERENA. Contact: jan.hasenauer@helmholtz-muenchen.de or atefeh.kazeroonian@tum.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID:28881983

  5. Genetics Home Reference: cri-du-chat syndrome

    MedlinePlus

    ... Pinkel D. High-resolution mapping of genotype-phenotype relationships in cri du chat syndrome using array comparative ... for Links Data Files & API Site Map Subscribe Customer Support USA.gov Copyright Privacy Accessibility FOIA Viewers & ...

  6. Final analysis of cost, value, and risk.

    DOT National Transportation Integrated Search

    2009-03-05

    USDOT understands that access to emergency services provided by 9-1-1 in todays world of evolving : technology will ultimately occur within a broader array of interconnected networks comprehensively : supporting emergency servicesfrom public ac...

  7. RDFBuilder: a tool to automatically build RDF-based interfaces for MAGE-OM microarray data sources.

    PubMed

    Anguita, Alberto; Martin, Luis; Garcia-Remesal, Miguel; Maojo, Victor

    2013-07-01

    This paper presents RDFBuilder, a tool that enables RDF-based access to MAGE-ML-compliant microarray databases. We have developed a system that automatically transforms the MAGE-OM model and microarray data stored in the ArrayExpress database into RDF format. Additionally, the system automatically enables a SPARQL endpoint. This allows users to execute SPARQL queries for retrieving microarray data, either from specific experiments or from more than one experiment at a time. Our system optimizes response times by caching and reusing information from previous queries. In this paper, we describe our methods for achieving this transformation. We show that our approach is complementary to other existing initiatives, such as Bio2RDF, for accessing and retrieving data from the ArrayExpress database. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. Ultrafast Dynamic Pressure Sensors Based on Graphene Hybrid Structure.

    PubMed

    Liu, Shanbiao; Wu, Xing; Zhang, Dongdong; Guo, Congwei; Wang, Peng; Hu, Weida; Li, Xinming; Zhou, Xiaofeng; Xu, Hejun; Luo, Chen; Zhang, Jian; Chu, Junhao

    2017-07-19

    Mechanical flexible electronic skin has been focused on sensing various physical parameters, such as pressure and temperature. The studies of material design and array-accessible devices are the building blocks of strain sensors for subtle pressure sensing. Here, we report a new and facile preparation of a graphene hybrid structure with an ultrafast dynamic pressure response. Graphene oxide nanosheets are used as a surfactant to prevent graphene restacking in aqueous solution. This graphene hybrid structure exhibits a frequency-independent pressure resistive sensing property. Exceeding natural skin, such pressure sensors, can provide transient responses from static up to 10 000 Hz dynamic frequencies. Integrated by the controlling system, the array-accessible sensors can manipulate a robot arm and self-rectify the temperature of a heating blanket. This may pave a path toward the future application of graphene-based wearable electronics.

  9. Hierarchically MnO2-Nanosheet Covered Submicrometer-FeCo2O4-Tube Forest as Binder-Free Electrodes for High Energy Density All-Solid-State Supercapacitors.

    PubMed

    Zhu, Baogang; Tang, Shaochun; Vongehr, Sascha; Xie, Hao; Meng, Xiangkang

    2016-02-01

    The current problem of the still relatively low energy densities of supercapacitors can be effectively addressed by designing electrodes hierarchically on micro- and nanoscale. Herein, we report the synthesis of hierarchically porous, nanosheet covered submicrometer tube forests on Ni foam. Chemical deposition and thermal treatment result in homogeneous forests of 750 nm diameter FeCo2O4 tubes, which after hydrothermal reaction in KMnO4 are wrapped in MnO2-nanosheet-built porous covers. The covers' thickness can be adjusted from 200 to 800 nm by KMnO4 concentration. An optimal thickness (380 nm) with a MnO2 content of 42 wt % doubles the specific capacitance (3.30 F cm(-2) at 1.0 mA cm(-2)) of the bare FeCo2O4-tube forests. A symmetric solid-state supercapacitor made from these binder-free electrodes achieves 2.52 F cm(-2) at 2 mA cm(-2), much higher than reported for capacitors based on similar core-shell nanowire arrays. The large capacitance and high cell voltage of 1.7 V allow high energy and power densities (93.6 Wh kg(-1), 10.1 kW kg(-1)). The device also exhibits superior rate capability (71% capacitance at 20 mA cm(-2)) and remarkable cycling stability with 94% capacitance retention being stable after 1500 cycles.

  10. U-Pb Geochronology of Grandite Skarn Garnet: Case Studies From Jurassic Skarns of California

    NASA Astrophysics Data System (ADS)

    Gevedon, M. L.; Seman, S.; Barnes, J.; Stockli, D. F.; Lackey, J. S.

    2016-12-01

    We present 3 case studies using a new method for U-Pb dating grossular-andradite (grandite) skarn garnet via LA-ICP-MS (Seman et al., in prep). Grandite is commonly rich in U, with high Fe3+ contents generally correlating with higher U concentrations. Micron-scale non-radiogenic Pb heterogeneities allow for regression of age data using Tera-Wasserberg concordia. Although others have dated accessory skarn minerals, garnet U-Pb ages are powerful because garnet grows early and is nearly ubiquitous in skarns, resists alteration, and provides a formation age independent of that of the causative pluton. The Darwin stock (Argus range, eastern CA) was likely a short-lived, single pulse of magmatism, genetically related to the Darwin skarn. A robust skarn garnet U-Pb age of 176.8 ± 1.3 Ma agrees well with the pluton U-Pb zircon age of 175 Ma (Chen and Moore, 1982). Furthermore, zircon separated from, and in textural equilibrium with, exoskarn garnetite yields a U-Pb age of 176.8 ± 1 Ma. Such agreement between plutonic and skarn zircon ages with a skarn garnet age in a geologically simple field area is the ideal scenario for establishing grandite U-Pb as a viable tool for directly dating skarns. The Black Rock skarn (BRS; eastern CA) is more complex: multiple plutons and ambiguous field relations complicate determination of a causative pluton. A skarn garnet U-Pb age of 172.0 ± 3 Ma confirms a middle Jurassic BRS formation age. Investigation of 4 local plutons yield zircon U-Pb ages of 222 ± 3 Ma, 213 ± 4 Ma, 207 ± 4 Ma and 176.2 ± 2 Ma. Comparison of the skarn garnet U-Pb and pluton ages suggest the BRS is genetically related to the youngest pluton, providing basis for further field and geochemical investigation. The Whitehorse skarn (WS; Mojave Desert, CA) lies in an important region for studying the changing tectono-magmatic regime of the Jurassic North American Cordillera; basin fill suggests a tectonically-controlled oscillating regional shoreline (Busby, 2012). Values of δ18O of WS garnet are strongly negative, —9.8‰ to 1.2‰, and can only be the result of access to meteoric water. A grandite U-Pb age of 162.3 ± 2 Ma requires the region of the WS not be submerged below the sea at this time. Future work coupling grandite U-Pb and δ18O may be vital in establishing the timing of Jurassic Cordilleran tectonic changes in the Mojave Desert.

  11. Comparative satisfaction of receiving medical abortion service from nurses and auxiliary nurse-midwives or doctors in Nepal: results of a randomized trial.

    PubMed

    Tamang, Anand; Shah, Iqbal H; Shrestha, Pragya; Warriner, I K; Wang, Duolao; Thapa, Kusum; My Huong, N T; Meirik, Olav

    2017-12-16

    Early first-trimester medical abortion (MA) service (≤ 63 days) has been provided by doctors and nurses under doctors' supervision since 2009 in Nepal. This paper assesses whether MA services provided by specifically trained and certified nurses and auxiliary nurse-midwives independently from doctors' supervision, is considered as satisfactory by women as those provided by doctors. The data come from a multi-center, randomized, controlled equivalence trial conducted between April 2009 and March 2010 in five district hospitals in Nepal. Women seeking MA were randomly assigned to doctors or nurses and auxiliary nurse-midwives(ANMs).Eligible women were administered 200 mg mifepristone orally followed by 800 μg misoprostol vaginally two days later by their assigned providers and followed up 10-14 days later. At the follow-up visit women's reported satisfaction with MA service they received was measured. Of 1295 women screened for eligibility, 535 were randomly assigned to a doctor and 542 to a nurse or ANM. Nineteen women were lost-to-follow up in the former group and 27 were lost-to-follow up or did not complete the acceptability interview in the latter group. This study is, therefore, based on516womenin the doctor's group and 515 women in the nurse or ANM group. All women in the nurse or ANM group reported being satisfied or highly satisfied by MA compared to 99% in the doctor's group. Satisfaction was similar regardless of the type of provider; 38% among nurse or ANM and 35% among the doctor group were "highly satisfied", and 62% and 64%, respectively, were "satisfied". Women's experiences such as 'less than expected amount or duration of bleeding following MA', 'shorter than expected duration of the abortion process', and 'able to manage symptoms', were found to be associated with women's higher satisfaction with MA. Counseling and information on the method, potential complications of MA and post-abortion contraception was nearly universal. No statistically significant differences were found in the level of satisfaction by age, parity, marital status, education or occupation of women. Women's satisfaction with MA service provided by trained nurses or auxiliary nurse-midwives was similar to that provided by doctors. The findings, therefore, provide support for extending safe and accessible medical abortion services by government-trained nurses and auxiliary nurse midwives to women seeking early first trimester pregnancy termination. The trial was retrospectively registered with ClinicalTrials.gov (identifier: NCT01186302 ). Registered August 20, 2010.

  12. Carotid Artery Stenting With Proximal Embolic Protection via a Transradial or Transbrachial Approach: Pushing the Boundaries of the Technique While Maintaining Safety and Efficacy.

    PubMed

    Montorsi, Piero; Galli, Stefano; Ravagnani, Paolo M; Tresoldi, Simone; Teruzzi, Giovanni; Caputi, Luigi; Trabattoni, Daniela; Fabbiocchi, Franco; Calligaris, Giuseppe; Grancini, Luca; Lualdi, Alessandro; de Martini, Stefano; Bartorelli, Antonio L

    2016-08-01

    To compare the feasibility and safety of proximal cerebral protection to a distal filter during carotid artery stenting (CAS) via a transbrachial (TB) or transradial (TR) approach. Among 856 patients who underwent CAS between January 2007 and July 2015, 214 (25%) patients (mean age 72±8 years; 154 men) had the procedure via a TR (n=154) or TB (n=60) approach with either Mo.MA proximal protection (n=61) or distal filter protection (n=153). The Mo.MA group (mean age 73±7 years; 54 men) had significantly more men and more severe stenosis than the filter group (mean age 71±8 years; 100 men). Stent type and CAS technique were left to operator discretion. Heparin and a dedicated closure device or bivalirudin and manual compression were used in TR and TB accesses, respectively. Technical and procedure success, crossover to femoral artery, 30-day major adverse cardiovascular/cerebrovascular events (MACCE; death, all strokes, and myocardial infarction), vascular complications, and radiation exposure were compared between groups. Crossover to a femoral approach was required in 1/61 (1.6%) Mo.MA patient vs 11/153 (7.1%) filter patients mainly due to technical difficulty in engaging the target vessel. Five Mo.MA patients developed acute intolerance to proximal occlusion; 4 were successfully shifted to filter protection. A TR patient was shifted to filter because the Mo.MA system was too short. CAS was technically successful in the remaining 55 (90%) Mo.MA patients and 142 (93%) filter patients. The MACCE rate was 0% in the Mo.MA patients and 2.8% in the filter group (p=0.18). Radiation exposure was similar between groups. Major vascular complications occurred in 1/61 (1.6%) and in 3/153 (1.96%) patients in the Mo.MA and filter groups (p=0.18), respectively, and were confined to the TB approach in the early part of the learning curve. Chronic radial artery occlusion was detected by Doppler ultrasound in 2/30 (6.6%) Mo.MA patients and in 4/124 (3.2%) filter patients by clinical assessment (p=0.25) at 8.1±7.5-month follow-up. CAS with proximal protection via a TR or TB approach is a feasible, safe, and effective technique with a low rate of vascular complications. © The Author(s) 2016.

  13. Effective Padding of Multi-Dimensional Arrays to Avoid Cache Conflict Misses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hong, Changwan; Bao, Wenlei; Cohen, Albert

    Caches are used to significantly improve performance. Even with high degrees of set-associativity, the number of accessed data elements mapping to the same set in a cache can easily exceed the degree of associativity, causing conflict misses and lowered performance, even if the working set is much smaller than cache capacity. Array padding (increasing the size of array dimensions) is a well known optimization technique that can reduce conflict misses. In this paper, we develop the first algorithms for optimal padding of arrays for a set associative cache for arbitrary tile sizes, In addition, we develop the first solution tomore » padding for nested tiles and multi-level caches. The techniques are in implemented in PAdvisor tool. Experimental results with multiple benchmarks demonstrate significant performance improvement from use of PAdvisor for padding.« less

  14. Fabrication of a 3D micro/nano dual-scale carbon array and its demonstration as the microelectrodes for supercapacitors

    NASA Astrophysics Data System (ADS)

    Jiang, Shulan; Shi, Tielin; Gao, Yang; Long, Hu; Xi, Shuang; Tang, Zirong

    2014-04-01

    An easily accessible method is proposed for the fabrication of a 3D micro/nano dual-scale carbon array with a large surface area. The process mainly consists of three critical steps. Firstly, a hemispherical photoresist micro-array was obtained by the cost-effective nanoimprint lithography process. Then the micro-array was transformed into hierarchical structures with longitudinal nanowires on the microstructure surface by oxygen plasma etching. Finally, the micro/nano dual-scale carbon array was fabricated by carbonizing these hierarchical photoresist structures. It has also been demonstrated that the micro/nano dual-scale carbon array can be used as the microelectrodes for supercapacitors by the electrodeposition of a manganese dioxide (MnO2) film onto the hierarchical carbon structures with greatly enhanced electrochemical performance. The specific gravimetric capacitance of the deposited micro/nano dual-scale microelectrodes is estimated to be 337 F g-1 at the scan rate of 5 mV s-1. This proposed approach of fabricating a micro/nano dual-scale carbon array provides a facile way in large-scale microstructures’ manufacturing for a wide variety of applications, including sensors and on-chip energy storage devices.

  15. KSC-00padig113

    NASA Image and Video Library

    2000-11-30

    A rising sun illuminates the coastal waters beyond Space Shuttle Endeavour, poised for launch on Nov. 30 at about 10:06 p.m. EST on mission STS-97. On the left, extending toward the orbiter, is the orbiter access arm. The mission to the International Space Station carries the P6 Integrated Truss Segment containing solar arrays and batteries that will be temporarily installed to the Unity connecting module by the Z1 truss, recently delivered to and installed on the Station on mission STS-92. The two solar arrays are each more than 100 feet long. They will capture energy from the sun and convert it to power for the Station. Two spacewalks will be required to install the solar array connections

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goltz, G.; Weiner, H.

    A computer program has been developed for designing and analyzing the performance of solar array/battery power systems for the U. S. Coast Guard Navigational Aids. This program is called the Design Synthesis/Performance Analysis (DSPA) Computer Program. The basic function of the Design Synthesis portion of the DSPA program is to evaluate functional and economic criteria to provide specifications for viable solar array/battery power systems. The basic function of the Performance Analysis portion of the DSPA program is to simulate the operation of solar array/battery power systems under specific loads and environmental conditions. This document provides all the information necessary tomore » access the DSPA programs, to input required data and to generate appropriate Design Synthesis or Performance Analysis Output.« less

  17. Acoustic Metadata Management and Transparent Access to Networked Oceanographic Data Sets

    DTIC Science & Technology

    2014-09-30

    Fisheries Science Center National Marine Fisheries Service 7600 Sand Point Way N.E., Building 4 Seattle, Washington 98115-6349 phone: (206) 526-6331...fax: (206) 526-6615 e-mail: Catherine.Berchok@noaa.gov Erin M. Oleson Pacific Islands Fisheries Science Center National Marine Fisheries ...Sofie M. Van Parijs Northeast Fisheries Science Center National Marine Fisheries Service 166 Water Street, Woods Hole, MA 02543 phone: (508) 495

  18. Branding: A Strategy for Manning an All-Volunteer Army

    DTIC Science & Technology

    2008-03-12

    Maytag (dependability); and Porsche (speed). Branding applies to businesses, religion , universities, congressmen, and even the military.54 The United...Carolyn A. Martin, Ph.D., and Bruce Tulgan, Managing Generation Y : Global Citizens Born in the Late Seventies and Early Eighties (Amherst, MA: HRD Press...available from Lexis Nexis; accessed 5 January 2008, see beginning section of article. 17 Carolyn Hirschman, “Here They Come: The millennials -- people

  19. Two LANL laboratory astrophysics experiments

    NASA Astrophysics Data System (ADS)

    Intrator, Thomas; Weber, Thomas; Feng, Yan; Hutchinson, Trevor; Dunn, John; Akcay, Cihan

    2014-06-01

    Two laboratory experiments are described that have been built at Los Alamos (LANL) to gain access to a wide range of fundamental plasma physics issues germane to astro, space, and fusion plasmas. The over arching theme is magnetized plasma dynamics which includes significant currents, MHD forces and instabilities, magnetic field creation and annihilation, sheared flows and shocks. The Relaxation Scaling Experiment (RSX) creates current sheets and flux ropes that exhibit fully 3D dynamics, and can kink, bounce, merge and reconnect, shred, and reform in complicated ways. Recent movies from a large data set describe the 3D magnetic structure of a driven and dissipative single flux rope that spontaneously self saturates a kink instability. Examples of a coherent shear flow dynamo driven by colliding flux ropes will also be shown.The Magnetized Shock Experiment (MSX) uses Field reversed configuration (FRC) experimental hardware that forms and ejects FRCs at 150km/sec. This is sufficient to drive a collision less magnetized shock when stagnated into a mirror stopping field region with Alfven Mach number MA=3 so that super critical shocks can be studied. We are building a plasmoid accelerator to drive Mach numbers MA >> 3 to access solar wind and more exotic astrophysical regimes. Unique features of this experiment include access to parallel, oblique and perpendicular shocks, shock region much larger than ion gyro radii and ion inertial length, room for turbulence, and large magnetic and fluid Reynolds numbers.*DOE Office of Fusion Energy Sciences under LANS contract DE-AC52-06NA25396, NASA Geospace NNHIOA044I, Basic, Center for Magnetic Self Organization

  20. Analysis of Ignitor Discharges with Double X-point Magnetic Configurations

    NASA Astrophysics Data System (ADS)

    Airoldi, A.; Cenacchi, G.; Coppi, B.

    2008-11-01

    The Ignitor experiment was proposed and designed to achieve ignited and sub-ignited conditions in well confined deuterium-tritium plasmas. Thanks to its unique features (high magnetic field up to 13 T, high plasma current up to 11 MA, and high plasma density up to 5 x10^20 m-3), Ignitor is the only device capable of exploring plasma regimes that are relevant to a net power producing D-T reactor and are not accessible to other existing or planned machines. Double X-point scenarios with magnetic field up to 13 T and plasma current up to 9 MA are analyzed. In these configurations, the access to a high confinement state is assumed when the available plasma heating power, supported by the injected auxiliary power, is larger than the L-H threshold value, according to recent suggested scalings The H-regime is modeled by a global reduction of the thermal transport coefficients used for the L-regime. Situations in the presence and in the absence of sawtooth oscillations have been investigated. Quasi-stationary conditions can be attained when a process producing re- distribution of pressure and current profiles is active. B.Coppi, A.Airoldi, F.Bombarda, et al.,Nucl. Fusion 41, 1253 (2001) D.C. McDonald, A.J. Meakins, et al., PPCF 48, A439 (2006).

  1. Imaging Spectrometer Designs Utilizing Immersed Gratings With Accessible Entrance Slit

    DOEpatents

    Chrisp, Michael P.; Lerner, Scott A.

    2006-03-21

    A compact imaging spectrometer comprises an entrance slit, a catadioptric lens with a mirrored surface, a grating, and a detector array. The entrance slit directs light to the mirrored surface of the catadioptric lens; the mirrored surface reflects the light back through the lens to the grating. The grating receives the light from the catadioptric lens and diffracts the light to the lens away from the mirrored surface. The lens transmits the light and focuses it onto the detector array.

  2. Toward self-assembled ferroelectric random access memories: hard-wired switching capacitor arrays with almost Tb/in.(2) densities.

    PubMed

    Evans, Paul R; Zhu, Xinhau; Baxter, Paul; McMillen, Mark; McPhillips, John; Morrison, Finlay D; Scott, James F; Pollard, Robert J; Bowman, Robert M; Gregg, J Marty

    2007-05-01

    We report on the successful fabrication of arrays of switchable nanocapacitors made by harnessing the self-assembly of materials. The structures are composed of arrays of 20-40 nm diameter Pt nanowires, spaced 50-100 nm apart, electrodeposited through nanoporous alumina onto a thin film lower electrode on a silicon wafer. A thin film ferroelectric (both barium titanate (BTO) and lead zirconium titanate (PZT)) has been deposited on top of the nanowire array, followed by the deposition of thin film upper electrodes. The PZT nanocapacitors exhibit hysteresis loops with substantial remnant polarizations, while although the switching performance was inferior, the low-field characteristics of the BTO nanocapacitors show dielectric behavior comparable to conventional thin film heterostructures. While registration is not sufficient for commercial RAM production, this is nevertheless an embryonic form of the highest density hard-wired FRAM capacitor array reported to date and compares favorably with atomic force microscopy read-write densities.

  3. Phospholipid arrays on porous polymer coatings generated by micro-contact spotting

    PubMed Central

    de Freitas, Monica; Tröster, Lea-Marie; Jochum, Tobias; Levkin, Pavel A; Hirtz, Michael; Fuchs, Harald

    2017-01-01

    Nanoporous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) (HEMA-EDMA) is used as a 3D mesh for spotting lipid arrays. Its porous structure is an ideal matrix for lipid ink to infiltrate, resulting in higher fluorescent signal intensity as compared to similar arrays on strictly 2D substrates like glass. The embedded lipid arrays show high stability against washing steps, while still being accessible for protein and antibody binding. To characterize binding to polymer-embedded lipids we have applied Streptavidin as well as biologically important biotinylated androgen receptor binding onto 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(cap biotinyl) (Biotinyl Cap PE) and anti-DNP IgE recognition of 2,4-dinitrophenyl[1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[6-[(2,4-dinitrophenyl)amino]hexanoyl] (DNP)] antigen. This approach adds lipid arrays to the range of HEMA polymer applications and makes this solid substrate a very attractive platform for a variety of bio-applications. PMID:28487815

  4. GaAs/AlGaAs core multishell nanowire-based light-emitting diodes on Si.

    PubMed

    Tomioka, Katsuhiro; Motohisa, Junichi; Hara, Shinjiroh; Hiruma, Kenji; Fukui, Takashi

    2010-05-12

    We report on integration of GaAs nanowire-based light-emitting-diodes (NW-LEDs) on Si substrate by selective-area metalorganic vapor phase epitaxy. The vertically aligned GaAs/AlGaAs core-multishell nanowires with radial p-n junction and NW-LED array were directly fabricated on Si. The threshold current for electroluminescence (EL) was 0.5 mA (current density was approximately 0.4 A/cm(2)), and the EL intensity superlinearly increased with increasing current injections indicating superluminescence behavior. The technology described in this letter could help open new possibilities for monolithic- and on-chip integration of III-V NWs on Si.

  5. Preliminary analysis of cost, value, and risk.

    DOT National Transportation Integrated Search

    2008-02-12

    The U.S. Department of Transportation (USDOT) understands that access to emergency services provided by 9-1-1 in todays world of evolving technology will ultimately occur within a broader array of interconnected networks comprehensively supporting...

  6. Innenstädte im ländlichen Raum - Wirksame Maßnahmen zur Revitalisierung zentraler Einzelhandelslagen im ruralen Umfeld

    NASA Astrophysics Data System (ADS)

    Hilpert, Markus; Völkening, Niklas; Beck, Christin

    2018-06-01

    In contrast to the retail sector in metropolises and medium-sized towns, its counterpart in rural regions is far less examined and described in scientific geographic literature. As many rural communities face similar challenges (e. g. growing vacancy rates, insufficient accessibility and unresolved succession in businesses), this article expounds fundamental mechanisms for strengthening or at least stabilizing their attractiveness as environments for living and for economy. Next to "hard" facts, as for example accessibility and parking spaces, less tangible themes like quality of stay, multicontextuality or service as well as comprehensive concepts like city marketing or place branding take on greater significance.

  7. Recent exhumational pattern across the Lhasa Terrain: Revealed by detrital zircon fission track and U/Pb ages from modern fluvial sediments along Yarlung-Tsangpo, South Tibet

    NASA Astrophysics Data System (ADS)

    Huang, Shao-Yi; Chen, Yue-Gau; Liu, Tsung-Kwei; Cao, Zhongquan

    2010-05-01

    Detrital samples from the foreland basin and so forth depositional environments archive the evolutional phases of adjacent orogens. Modern fluvial sediments, similarly, provide the integrated information of exposed bedrocks in the studied drainages where sometimes few access is allowed to get the in situ samples. However, the nature of the dispersed detrital ages has long hampered our interpretation in thermal evolution and surface processes of the studied terrain, mainly spatial-wise. With suitable thermo-chronometers, multiple dated single-grain ages can shed a light on the provenance of studied grains and limit the uncertainties of plausible source areas. In this study, we present the detrital zircon fission track (ZFT) and U/Pb ages from the modern fluvial sediments collected along the Yarlung-Tsangpo and its two tributaries, Lhasa River and Nyang River. The sample collected from Lhasa River (LS) shows its ZFT age population peaks as: 1.5 Ma (2.1%), 6.8 Ma (44.5%), 11.3 Ma (34.1%), and 32.5 Ma (19.3%) while the sample collected from Nyang River ( BY) shows the age peaks as: 6.2 Ma (10.3%), 22.8 Ma (36.3%), and 51.6 Ma (53.4%). The ZFT ages are much younger than the bedrock strata of Lhasa terrain (Proterozoic to Mesozoic) and most of the intrusive Gangdese belt (Mesozoic to Mid-Miocene). So far, our U/Pb ages from LS has corresponded to published Gangdese intrusion ages and further confirm that the majority of analyzed grains exhibit consistent young ZFT ages, indicating a significant exhumational phase in the Lhasa Terrain from 15-6 Ma. However, the occurrence of this recent exhumation may not be contemporary and the magnitude must be diverse across the Lhasa Terrain. Evidently, we observe a dramatic decrease of younger ZFT age population (grain ages younger than 15 Ma) descending from ~78% in the Lhasa River drainage down to less than 15% in the Nyang River drainage. On the other hand, the older population (grain ages > 15 Ma) shifts from ~20% (Lhasa River) to ~85% (Nyang River). This significant discrepancy of age population suggests that the two drainages could have undergone different scenarios of exhumation. In short, detrital ZFT and U/Pb single grain ages in this study present a clear picture of recent exhumation around 15-6 Ma in the SE Lhasa Terrain. The span and magnitude of exhumation appear to be discordant across the Lhasa Terrain. With more knowledge of the in situ ages from exposed bedrocks and more densely monitored samples in studied catchments, our future step is to map the discrepancy of age population which reflects the recent denudation signals and to further estimate the contribution of potential sources.

  8. Expanding proteome coverage with orthogonal-specificity α-Lytic proteases

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meyer, Jesse G.; Kim, Sangtae; Maltby, David A.

    2014-03-01

    Bottom-up proteomics studies traditionally involve proteome digestion with a single protease, trypsin. However, trypsin alone does not generate peptides that encompass the entire proteome. Alternative proteases have been explored, but most have specificity for charged amino acid side chains. Therefore, additional proteases that improve proteome coverage by cleavage at sequences complimentary to trypsin may increase proteome coverage. We demonstrate the novel application of two proteases for bottom-up proteomics: wild type alpha-lytic protease (WaLP), and an active site mutant of WaLP, M190A alpha-lytic protease (MaLP). We assess several relevant factors including MS/MS fragmentation, peptide length, peptide yield, and protease specificity. Bymore » combining data from separate digestions with trypsin, LysC, WaLP, and MaLP, proteome coverage was increased 101% compared to trypsin digestion alone. To demonstrate how the gained sequence coverage can access additional PTM information, we show identification of a number of novel phosphorylation sites in the S. pombe proteome and include an illustrative example from the protein MPD2, wherein two novel sites are identified, one in a tryptic peptide too short to identify and the other in a sequence devoid of tryptic sites. The specificity of WaLP and MaLP for aliphatic amino acid side chains was particularly valuable for coverage of membrane protein sequences, which increased 350% when the data from trypsin, LysC, WaLP, and MaLP were combined.« less

  9. Reconstructing Eolian Delivery to the Ulleung Basin (IODP Site U1430) Over the Past 12 Myr

    NASA Astrophysics Data System (ADS)

    Anderson, C. H.; Dunlea, A. G.; Murray, R. W.; Tada, R.; Alvarez Zarikian, C. A.

    2017-12-01

    Spring storms associated with the seasonal phases of the East Asian Monsoon (EAM), transport dust seaward and influence marine sedimentation in adjacent ocean regions. Here, we aim to track changes in the intensity of the EAM since the late Miocene by examining the relative proportions and sources of eolian inputs in marine sediment records. We use bulk sediment recovered from Site U1430 in the Ulleung Basin during Integrated Ocean Drilling Program Expedition 346 in 2013 to examine changes in the EAM over the past 12 Myr. Sediment recovered at this site is clayey silt, nannofossil and diatom oozes, claystone, and basal glauonitic sandstone. We analyze major, trace, and rare earth element concentrations for 72 bulk sediment samples analyzed by ICP-ES and ICP-MS, and interpret this dataset using a variety of multivariate statistical partitioning techniques (Q-mode Factor Analyses (QFA), Multiple Linear Regressions) to investigate sediment provenance. Sedimentologic observations and elemental concentrations indicate the presence of biogenic siliceous and carbonaceous components mixed with aluminosilicates. For example, Si/Al (g/g) reaches local maxima at 3 Ma and 10 Ma in several diatom rich sections, and Ca/Al (g/g) exhibits a peak at 0.58 Ma. Other downhole element ratios exhibit subtle variations, including Ti/Al of 0.05 +/- 0.004 g/g, Sc/Al 2 +/- 0.2 ug/g, and Rb/Al 17 +/- 1.5 ug/g. When plotted in ternary diagrams, samples exhibit offset arrays (La-Th-Sc) or multiple clusters (Zr-Nb-Sc) from an Upper Continental Crust and Mid-Ocean Ridge Basalt mixing line. In Th-Cr-Nb, the data exhibit a V-shaped array. The range of geochemical variability suggests that multiple sources of terrigenous matter and/or volcanic ash are being delivered to the site. The multivariate statistics also indicate the mixing of multiple aluminosilicate sources. Focusing on a suite of seven elements (Al, Ti, Sc, Cr, Rb, Th, La), preliminary QFA suggest that five factors are required to explain 99% of the variability in the dataset. Factors group different co-varying elements: Factor 1 Zr and Th, Factor 2 only Cr, Factor 3 Sc and La, Factor 4 Al and Sc, and Factor 5 with Rb and Th. Terrigenous inputs are likely from several sources including loess and other continental crustal material, and will be discussed further.

  10. A Broadband Investigation of the Texas/Gulf of Mexico Passive Margin

    NASA Astrophysics Data System (ADS)

    Evanzia, D.; Ainsworth, R.; Pratt, K. W.; Pulliam, J.; Gurrola, H.

    2012-12-01

    The lithosphere of central and east Texas underwent two cycles of continental rifting and orogeny from the formation of Laurentia and assembly through the breakup of Pangea. The craton itself, exposed in the Llano uplift of central Texas, formed ~1.4 Ga as part of the great expanse of Mesoproterozoic crust that makes up southern Laurentia. Some of this crust was deformed during the Grenville orogeny ~1.1 Ga. Southern Laurentia was subsequently stable until rifting began in Cambrian time (~530 Ma). Suturing of Gondwana to Laurentia (310-290 Ma) during the assembly of Pangea formed the Ouachita orogen in west Texas. Sometime before 200 Ma rifting was initiated, opening the Gulf of Mexico (GoM). In north and east Texas the Ouachita front lies north of GoM rifting but, according to deep seismic data, Ouachita structures appear to coincide with GoM rifting in south and central Texas. This suggests that rifting in that region occurred along structures that were weakened previously by Ouachita deformation and reactivated during the Jurassic opening of the GoM. It is not clear whether the process that created the Gulf of Mexico and led to the formation of Texas' Gulf Coast Plain (GCP) is best described as "active" or "passive" rifting. A recent study interpreted the GCP to be a volcanic rifted margin—an active rifting process—using available gravity, magnetic, drilling and geological data, but older studies describe the opening of the GoM as a passive event. In the coastal plain, a large magnetic anomaly suggests that the crust here was modified by volcanism. Seismic data are sparse and of limited quality in the Gulf Coast region so we conducted a 2.5-year broadband seismograph transect across the GCP in an effort to clarify its structure and origin. In all, twenty-three broadband seismographs were deployed in a line from Matagorda Island, in the Gulf of Mexico, to Johnson City, TX, on the uplifted Llano Plateau from July 2010 to December 2012. These seismographs have an average spacing of 15 km and coincided with the deployment of EarthScope Transportable Array stations in central and east Texas. We will present the results of P- and S-wave tomographic inversions for upper mantle structure beneath the array.

  11. Access control violation prevention by low-cost infrared detection

    NASA Astrophysics Data System (ADS)

    Rimmer, Andrew N.

    2004-09-01

    A low cost 16x16 un-cooled pyroelectric detector array, allied with advanced tracking and detection algorithms, has enabled the development of a universal detector with a wide range of applications in people monitoring and homeland security. Violation of access control systems, whether controlled by proximity card, biometrics, swipe card or similar, may occur by 'tailgating' or 'piggybacking' where an 'approved' entrant with a valid entry card is accompanied by a closely spaced 'non-approved' entrant. The violation may be under duress, where the accompanying person is attempting to enter a secure facility by force or threat. Alternatively, the violation may be benign where staff members collude either through habit or lassitude, either with each other or with third parties, without considering the security consequences. Examples of the latter could include schools, hospitals or maternity homes. The 16x16 pyroelectric array is integrated into a detector or imaging system which incorporates data processing, target extraction and decision making algorithms. The algorithms apply interpolation to the array output, allowing a higher level of resolution than might otherwise be expected from such a low resolution array. The pyroelectric detection principle means that the detection will work in variable light conditions and even in complete darkness, if required. The algorithms can monitor the shape, form, temperature and number of persons in the scene and utilise this information to determine whether a violation has occurred or not. As people are seen as 'hot blobs' and are not individually recognisable, civil liberties are not infringed in the detection process. The output from the detector is a simple alarm signal which may act as input to the access control system as an alert or to trigger CCTV image display and storage. The applications for a tailgate detector can be demonstrated across many medium security applications where there are no physical means to prevent this type of security breach.

  12. SAR processing on the MPP

    NASA Technical Reports Server (NTRS)

    Batcher, K. E.; Eddey, E. E.; Faiss, R. O.; Gilmore, P. A.

    1981-01-01

    The processing of synthetic aperture radar (SAR) signals using the massively parallel processor (MPP) is discussed. The fast Fourier transform convolution procedures employed in the algorithms are described. The MPP architecture comprises an array unit (ARU) which processes arrays of data; an array control unit which controls the operation of the ARU and performs scalar arithmetic; a program and data management unit which controls the flow of data; and a unique staging memory (SM) which buffers and permutes data. The ARU contains a 128 by 128 array of bit-serial processing elements (PE). Two-by-four surarrays of PE's are packaged in a custom VLSI HCMOS chip. The staging memory is a large multidimensional-access memory which buffers and permutes data flowing with the system. Efficient SAR processing is achieved via ARU communication paths and SM data manipulation. Real time processing capability can be realized via a multiple ARU, multiple SM configuration.

  13. Flexible Organic Electronics for Use in Neural Sensing

    PubMed Central

    Bink, Hank; Lai, Yuming; Saudari, Sangameshwar R.; Helfer, Brian; Viventi, Jonathan; Van der Spiegel, Jan; Litt, Brian; Kagan, Cherie

    2016-01-01

    Recent research in brain-machine interfaces and devices to treat neurological disease indicate that important network activity exists at temporal and spatial scales beyond the resolution of existing implantable devices. High density, active electrode arrays hold great promise in enabling high-resolution interface with the brain to access and influence this network activity. Integrating flexible electronic devices directly at the neural interface can enable thousands of multiplexed electrodes to be connected using many fewer wires. Active electrode arrays have been demonstrated using flexible, inorganic silicon transistors. However, these approaches may be limited in their ability to be cost-effectively scaled to large array sizes (8×8 cm). Here we show amplifiers built using flexible organic transistors with sufficient performance for neural signal recording. We also demonstrate a pathway for a fully integrated, amplified and multiplexed electrode array built from these devices. PMID:22255558

  14. An analog of photon-assisted tunneling in a periodically modulated waveguide array

    PubMed Central

    Li, Liping; Luo, Xiaobing; Yang, Xiaoxue; Wang, Mei; Lü, Xinyou; Wu, Ying

    2016-01-01

    We theoretically report an analog of photon-assisted tunneling (PAT) originated from dark Floquet state in a periodically driven lattice array without a static biased potential by studying a three-channel waveguide system in a non-high-frequency regime. This analog of PAT can be achieved by only periodically modulating the top waveguide and adjusting the distance between the bottom and its adjacent waveguide. It is numerically shown that the PAT resonances also exist in the five-channel waveguide system and probably exist in the waveguide arrays with other odd numbers of waveguides, but they will become weak as the number of waveguides increases. With origin different from traditional PAT, this type of PAT found in our work is closely linked to the existence of the zero-energy (dark) Floquet states. It is readily observable under currently accessible experimental conditions and may be useful for controlling light propagation in waveguide arrays. PMID:27767189

  15. 47 CFR 15.615 - General administrative requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

  16. 47 CFR 15.615 - General administrative requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

  17. 47 CFR 15.615 - General administrative requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

  18. 47 CFR 15.615 - General administrative requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

  19. 47 CFR 15.615 - General administrative requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-2190.5 kHz. Within the exclusion zone for the Very Large Array radio astronomy observatory, Access BPL... facilities located at the coordinates specified for radio astronomy facilities in 47 CFR 2.106, Note U.S. 311...

  20. Methodology for fast detection of false sharing in threaded scientific codes

    DOEpatents

    Chung, I-Hsin; Cong, Guojing; Murata, Hiroki; Negishi, Yasushi; Wen, Hui-Fang

    2014-11-25

    A profiling tool identifies a code region with a false sharing potential. A static analysis tool classifies variables and arrays in the identified code region. A mapping detection library correlates memory access instructions in the identified code region with variables and arrays in the identified code region while a processor is running the identified code region. The mapping detection library identifies one or more instructions at risk, in the identified code region, which are subject to an analysis by a false sharing detection library. A false sharing detection library performs a run-time analysis of the one or more instructions at risk while the processor is re-running the identified code region. The false sharing detection library determines, based on the performed run-time analysis, whether two different portions of the cache memory line are accessed by the generated binary code.

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