Science.gov

Sample records for accident conditions sac

  1. Full-length fuel rod behavior under severe accident conditions

    SciTech Connect

    Lombardo, N J; Lanning, D D; Panisko, F E

    1992-12-01

    This document presents an assessment of the severe accident phenomena observed from four Full-Length High-Temperature (FLHT) tests that were performed by the Pacific Northwest Laboratory (PNL) in the National Research Universal (NRU) reactor at Chalk River, Ontario, Canada. These tests were conducted for the US Nuclear Regulatory Commission (NRC) as part of the Severe Accident Research Program. The objectives of the test were to simulate conditions and provide information on the behavior of full-length fuel rods during hypothetical, small-break, loss-of-coolant severe accidents, in commercial light water reactors.

  2. Graphite Oxidation Simulation in HTR Accident Conditions

    SciTech Connect

    El-Genk, Mohamed

    2012-10-19

    Massive air and water ingress, following a pipe break or leak in steam-generator tubes, is a design-basis accident for high-temperature reactors (HTRs). Analysis of these accidents in both prismatic and pebble bed HTRs requires state-of-the-art capability for predictions of: 1) oxidation kinetics, 2) air helium gas mixture stratification and diffusion into the core following the depressurization, 3) transport of multi-species gas mixture, and 4) graphite corrosion. This project will develop a multi-dimensional, comprehensive oxidation kinetics model of graphite in HTRs, with diverse capabilities for handling different flow regimes. The chemical kinetics/multi-species transport model for graphite burning and oxidation will account for temperature-related changes in the properties of graphite, oxidants (O2, H2O, CO), reaction products (CO, CO2, H2, CH4) and other gases in the mixture (He and N2). The model will treat the oxidation and corrosion of graphite in geometries representative of HTR core component at temperatures of 900°C or higher. The developed chemical reaction kinetics model will be user-friendly for coupling to full core analysis codes such as MELCOR and RELAP, as well as computational fluid dynamics (CFD) codes such as CD-adapco. The research team will solve governing equations for the multi-dimensional flow and the chemical reactions and kinetics using Simulink, an extension of the MATLAB solver, and will validate and benchmark the model's predictions using reported experimental data. Researchers will develop an interface to couple the validated model to a commercially available CFD fluid flow and thermal-hydraulic model of the reactor , and will perform a simulation of a pipe break in a prismatic core HTR, with the potential for future application to a pebble-bed type HTR.

  3. The TOPAZ II space reactor response under accident conditions

    SciTech Connect

    Voss, S.S.

    1993-12-31

    The TOPAZ II is a single-cell thermionic space reactor power system developed by the Russians during the period of time from {approximately}1969 to 1989. The TOPAZ II has never been flight demonstrated, but the system was extensively tested on the ground. As part of the development and test program, the response of the TOPAZ II under accident conditions was analyzed and characterized. The US TOPAZ II team has been working closely with the Russian specialists to understand the TOPAZ II system, its operational characteristics, and its response under potential accident conditions. The purpose of the technical exchange is to enable a potential launch of a TOPAZ II by the US. The information is required to integrate the system with a US spacecraft and to support the safety review process. The purpose of this paper is to provide a brief overview of the system and its response under actual and postulated accident conditions.

  4. Tellurium behavior in containment under light water reactor accident conditions

    SciTech Connect

    Beahm, E.C.

    1986-02-01

    Interactions of tellurium in containment can result in changes of physical form and therefore in its transport properties. This report discusses the most probable forms of tellurium in a containment environment under LWR accident conditions. The physical and chemical form of inorganic tellurium species will be determined by condensation, oxidation, and dissolution in water. Of the three volatile tellurium chemical forms, Te/sub 2/ (gas), H/sub 2/Te, and organic tellurides, only organic tellurides have the potential to remain in the gas phase in a containment atmosphere. There is a general lack of information on the formation and removal of organic tellurides under LWR accident conditions. 41 refs.

  5. Predictions of structural integrity of steam generator tubes under normal operating, accident, and severe accident conditions

    SciTech Connect

    Majumdar, S.

    1996-09-01

    Available models for predicting failure of flawed and unflawed steam generator tubes under normal operating, accident, and severe accident conditions are reviewed. Tests conducted in the past, though limited, tended to show that the earlier flow-stress model for part-through-wall axial cracks overestimated the damaging influence of deep cracks. This observation is confirmed by further tests at high temperatures as well as by finite element analysis. A modified correlation for deep cracks can correct this shortcoming of the model. Recent tests have shown that lateral restraint can significantly increase the failure pressure of tubes with unsymmetrical circumferential cracks. This observation is confirmed by finite element analysis. The rate-independent flow stress models that are successful at low temperatures cannot predict the rate sensitive failure behavior of steam generator tubes at high temperatures. Therefore, a creep rupture model for predicting failure is developed and validated by tests under varying temperature and pressure loading expected during severe accidents.

  6. Response of HEPA filters to simulated-accident conditions

    SciTech Connect

    Gregory, W.S.; Martin, R.A.; Smith, P.R.; Fenton, D.E.

    1982-01-01

    High-efficiency particulate air (HEPA) filters have been subjected to simulated accident conditions to determine their response to abnormal operating events. Both domestic and European standard and high-capacity filters have been evaluated to determine their response to simulated fire, explosion, and tornado conditions. The HEPA filter structural limitations for tornado and explosive loadings are discussed. In addition, filtration efficiencies during these accident conditions are reported for the first time. Our data indicate efficiencies between 80% and 90% for shock loadings below the structural limit level. We describe two types of testing for ineffective filtration - clean filters exposed to pulse-entrained aerosol and dirty filters exposed to tornado and shock pulses. Efficiency and material loss data are described. Also, the resonse of standard HEPA filters to simulated fire conditions is presented. We describe a unique method of measuring accumulated combustion products on the filter. Additionally, data relating to pressure drop vs accumulated mass during plugging are reported for simulated combustion aerosols. The effects of concentration and moisture levels on filter plugging were evaluated. We are obtaining all of the above data so that mathematical models can be developed for fire, explosion, and tornado accident analysis computer codes. These computer codes can be used to assess the response of nuclear air cleaning systems to accident conditions.

  7. Predictions of structural integrity of steam generator tubes under normal operating, accident, an severe accident conditions

    SciTech Connect

    Majumdar, S.

    1997-02-01

    Available models for predicting failure of flawed and unflawed steam generator tubes under normal operating, accident, and severe accident conditions are reviewed. Tests conducted in the past, though limited, tended to show that the earlier flow-stress model for part-through-wall axial cracks overestimated the damaging influence of deep cracks. This observation was confirmed by further tests at high temperatures, as well as by finite-element analysis. A modified correlation for deep cracks can correct this shortcoming of the model. Recent tests have shown that lateral restraint can significantly increase the failure pressure of tubes with unsymmetrical circumferential cracks. This observation was confirmed by finite-element analysis. The rate-independent flow stress models that are successful at low temperatures cannot predict the rate-sensitive failure behavior of steam generator tubes at high temperatures. Therefore, a creep rupture model for predicting failure was developed and validated by tests under various temperature and pressure loadings that can occur during postulated severe accidents.

  8. Investigation of air cleaning system response to accident conditions

    SciTech Connect

    Andrae, R.W.; Bolstad, J.W.; Foster, R.D.; Gregory, W.S.; Horak, H.L.; Idar, E.S.; Martin, R.A.; Ricketts, C.I.; Smith, P.R.; Tang, P.K.

    1980-01-01

    Air cleaning system response to the stress of accident conditions are being investigated. A program overview and hghlight recent results of our investigation are presented. The program includes both analytical and experimental investigations. Computer codes for predicting effects of tornados, explosions, fires, and material transport are described. The test facilities used to obtain supportive experimental data to define structural integrity and confinement effectiveness of ventilation system components are described. Examples of experimental results for code verification, blower response to tornado transients, and filter response to tornado and explosion transients are reported.

  9. Fission product release from irradiated LWR fuel under accident conditions

    SciTech Connect

    Strain, R.V.; Sanecki, J.E.; Osborne, M.F.

    1984-01-01

    Fission product release from irradiated LWR fuel is being studied by heating fuel rod segments in flowing steam and an inert carrier gas to simulate accident conditions. Fuels with a range of irradiation histories are being subjected to several steam flow rates over a wide range of temperatures. Fission product release during each test is measured by gamma spectroscopy and by detailed examination of the collection apparatus after the test has been completed. These release results are complemented by a detailed posttest examination of samples of the fuel rod segment. Results of release measurements and fuel rod characterizations for tests at 1400 through 2000/sup 0/C are presented in this paper.

  10. Preliminary assessment of accident-tolerant fuels on LWR performance during normal operation and under DB and BDB accident conditions

    NASA Astrophysics Data System (ADS)

    Ott, L. J.; Robb, K. R.; Wang, D.

    2014-05-01

    Following the severe accidents at the Japanese Fukushima Daiichi Nuclear Power Station in 2011, the US Department of Energy initiated research and development on the enhancement of the accident tolerance of light water reactors by the development of fuels/cladding that, in comparison with the standard UO2/Zircaloy (Zr) system, can tolerate loss of active cooling in the core for a considerably longer time period while maintaining or improving the fuel performance during normal operations. Analyses are presented that illustrate the impact of these new candidate fuel/cladding materials on the fuel performance at normal operating conditions and on the reactor system under DB and BDB accident conditions.

  11. Heat Transfer in Cane Fiberboard Exposed to Hypothetical Accident Conditions

    SciTech Connect

    Gromada, R.J.

    1995-05-25

    Radioactive material packages containing fiberboard insulation have been subjected to Hypothetical Accident Condition (HAC) thermal tests for many years. Historically, the packages` thermal performance has always been difficult to grasp. A package designer needs to understand the effects of temperature and pyrolysis on the rate of heat transfer and performance. This paper describes in detail the one-dimensional HAC thermal tests performed on fiberboard to understand the effects of pyrolysis, its char and its gas products. The tests were conducted by the Packaging and Transportation Group at the Savannah River Site (SRS). Test fixtures were assembled at SRS and thermal testing conducted in the Radiant Heat Facility at the Sandia National Laboratories. Descriptions of the test fixtures are provided, as well as the time dependent temperature profiles. In addition, lessons learned are discussed.

  12. Electrical equipment performance under severe accident conditions (BWR/Mark 1 plant analysis): Summary report

    SciTech Connect

    Bennett, P.R.; Kolaczkowski, A.M.; Medford, G.T.

    1986-09-01

    The purpose of the Performance Evaluation of Electrical Equipment during Severe Accident States Program is to determine the performance of electrical equipment, important to safety, under severe accident conditions. In FY85, a method was devised to identify important electrical equipment and the severe accident environments in which the equipment was likely to fail. This method was used to evaluate the equipment and severe accident environments for Browns Ferry Unit 1, a BWR/Mark I. Following this work, a test plan was written in FY86 to experimentally determine the performance of one selected component to two severe accident environments.

  13. Key Parameters for Operator Diagnosis of BWR Plant Condition during a Severe Accident

    SciTech Connect

    Clayton, Dwight A.; Poore, III, Willis P.

    2015-01-01

    The objective of this research is to examine the key information needed from nuclear power plant instrumentation to guide severe accident management and mitigation for boiling water reactor (BWR) designs (specifically, a BWR/4-Mark I), estimate environmental conditions that the instrumentation will experience during a severe accident, and identify potential gaps in existing instrumentation that may require further research and development. This report notes the key parameters that instrumentation needs to measure to help operators respond to severe accidents. A follow-up report will assess severe accident environmental conditions as estimated by severe accident simulation model analysis for a specific US BWR/4-Mark I plant for those instrumentation systems considered most important for accident management purposes.

  14. In-vessel flow characterization under severe accident conditions

    SciTech Connect

    Nourbakhsh, H.P.; Kim, S.B.; Khatib-Rahbar, M.

    1987-01-01

    The purpose of this study is to provide a parametric framework for characterization of flow and heat transfer regimes and their associated phenomenological uncertainties following severe accidents using a two dimensional, heterogenous, porous media formulation. This approach extends the understanding of buoyancy-induced flow characteristics in the uncovered region of the reactor core and the upper plenum of a PWR vessel. The results of this study can be used to augment the boil-off steam flow in integrated one-dimensional severe accident codes such as the Source Team Code Package (STCP).

  15. Chemistry of fission product iodine under nuclear reactor accident conditions

    SciTech Connect

    Malinauskas, A.P.; Bell, J.T.

    1986-01-01

    The radioisotopes of iodine are generally acknowledged to be the species whose release into the biosphere as a result of a nuclear reactor accident is of the greatest concern. In the course of its release, the fission product is subjected to differing chemical environments; these can alter the physicochemical form of the fission product and thus modify the manner and extent to which release occurs. Both the chemical environments which are characteristic of reactor accidents and their effect in determining physical and chemical form of fission product iodine have been studied extensively, and are reviewed in this report. 76 refs.

  16. Accident Conditions versus Regulatory Test for NRC-Approved UF6 Packages

    SciTech Connect

    MILLS, G. SCOTT; AMMERMAN, DOUGLAS J.; LOPEZ, CARLOS

    2003-01-01

    The Nuclear Regulatory Commission (NRC) approves new package designs for shipping fissile quantities of UF{sub 6}. Currently there are three packages approved by the NRC for domestic shipments of fissile quantities of UF{sub 6}: NCI-21PF-1; UX-30; and ESP30X. For approval by the NRC, packages must be subjected to a sequence of physical tests to simulate transportation accident conditions as described in 10 CFR Part 71. The primary objective of this project was to relate the conditions experienced by these packages in the tests described in 10 CFR Part 71 to conditions potentially encountered in actual accidents and to estimate the probabilities of such accidents. Comparison of the effects of actual accident conditions to 10 CFR Part 71 tests was achieved by means of computer modeling of structural effects on the packages due to impacts with actual surfaces, and thermal effects resulting from test and other fire scenarios. In addition, the likelihood of encountering bodies of water or sufficient rainfall to cause complete or partial immersion during transport over representative truck routes was assessed. Modeled effects, and their associated probabilities, were combined with existing event-tree data, plus accident rates and other characteristics gathered from representative routes, to derive generalized probabilities of encountering accident conditions comparable to the 10 CFR Part 71 conditions. This analysis suggests that the regulatory conditions are unlikely to be exceeded in real accidents, i.e. the likelihood of UF{sub 6} being dispersed as a result of accident impact or fire is small. Moreover, given that an accident has occurred, exposure to water by fire-fighting, heavy rain or submersion in a body of water is even less probable by factors ranging from 0.5 to 8E-6.

  17. Potential behavior of depleted uranium penetrators under shipping and bulk storage accident conditions

    SciTech Connect

    Mishima, J.; Parkhurst, M.A.; Scherpelz, R.I.

    1985-03-01

    An investigation of the potential hazard from airborne releases of depleted uranium (DU) from the Army's M829 munitions was conducted at the Pacific Northwest Laboratory. The study included: (1) assessing the characteristics of DU oxide from an April 1983 burn test, (2) postulating conditions of specific accident situations, and (3) reviewing laboratory and theoretical studies of oxidation and airborne transport of DU from accidents. Results of the experimental measurements of the DU oxides were combined with atmospheric transport models and lung and kidney exposure data to help establish reasonable exclusion boundaries to protect personnel and the public at an accident site. 121 references, 44 figures, 30 tables.

  18. Fuel Accident Condition Simulator (FACS) Furnace for Post-Irradiation Heating Tests of VHTR Fuel Compacts

    SciTech Connect

    Paul A Demkowicz; Paul Demkowicz; David V Laug

    2010-10-01

    Abstract –Fuel irradiation testing and post-irradiation examination are currently in progress as part of the Next Generation Nuclear Plant Fuels Development and Qualification Program. The PIE campaign will include extensive accident testing of irradiated very high temperature reactor fuel compacts to verify fission product retention characteristics at high temperatures. This work will be carried out at both the Idaho National Laboratory (INL) and the Oak Ridge National Laboratory, beginning with accident tests on irradiated fuel from the AGR-1 experiment in 2010. A new furnace system has been designed, built, and tested at INL to perform high temperature accident tests. The Fuel Accident Condition Simulator furnace system is designed to heat fuel specimens at temperatures up to 2000°C in helium while monitoring the release of volatile fission metals (e.g. Cs, Ag, Sr, Eu, and I) and fission gases (Kr, Xe). Fission gases released from the fuel to the sweep gas are monitored in real time using dual cryogenic traps fitted with high purity germanium detectors. Condensable fission products are collected on a plate attached to a water-cooled cold finger that can be exchanged periodically without interrupting the test. Analysis of fission products on the condensation plates involves dry gamma counting followed by chemical analysis of selected isotopes. This paper will describe design and operational details of the Fuel Accident Condition Simulator (FACS) furnace system, as well as preliminary system calibration results.

  19. Historical civilian nuclear accident based Nuclear Reactor Condition Analyzer

    NASA Astrophysics Data System (ADS)

    McCoy, Kaylyn Marie

    There are significant challenges to successfully monitoring multiple processes within a nuclear reactor facility. The evidence for this observation can be seen in the historical civilian nuclear incidents that have occurred with similar initiating conditions and sequences of events. Because there is a current lack within the nuclear industry, with regards to the monitoring of internal sensors across multiple processes for patterns of failure, this study has developed a program that is directed at accomplishing that charge through an innovation that monitors these systems simultaneously. The inclusion of digital sensor technology within the nuclear industry has appreciably increased computer systems' capabilities to manipulate sensor signals, thus making the satisfaction of these monitoring challenges possible. One such manipulation to signal data has been explored in this study. The Nuclear Reactor Condition Analyzer (NRCA) program that has been developed for this research, with the assistance of the Nuclear Regulatory Commission's Graduate Fellowship, utilizes one-norm distance and kernel weighting equations to normalize all nuclear reactor parameters under the program's analysis. This normalization allows the program to set more consistent parameter value thresholds for a more simplified approach to analyzing the condition of the nuclear reactor under its scrutiny. The product of this research provides a means for the nuclear industry to implement a safety and monitoring program that can oversee the system parameters of a nuclear power reactor facility, like that of a nuclear power plant.

  20. 10 CFR 71.74 - Accident conditions for air transport of plutonium.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Accident conditions for air transport of plutonium. 71.74 Section 71.74 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE... plutonium. (a) Test conditions—Sequence of tests. A package must be physically tested to the...

  1. Analysis of concrete containment structures under severe accident loading conditions

    SciTech Connect

    Porter, V.L.

    1993-12-31

    One of the areas of current interest in the nuclear power industry is the response of containment buildings to internal pressures that may exceed design pressure levels. Evaluating the response of structures under these conditions requires computing beyond design load to the ultimate load of the containment. For concrete containments, this requirement means computing through severe concrete cracking and into the regime of wide-spread plastic rebar and/or tendon response. In this regime of material response, an implicit code can have trouble converging. This paper describes some of the author`s experiences with Version 5.2 of ABAQUS Standard and the ABAQUS concrete model in computing the axisymmetric response of a prestressed concrete containment to ultimate global structural failure under high internal pressures. The effects of varying the tension stiffening parameter in the concrete material model and variations of the parameters for the CONTROLS option are discussed.

  2. Hydrogen-control systems for severe LWR accident conditions - a state-of-technology report

    SciTech Connect

    Hilliard, R K; Postma, A K; Jeppson, D W

    1983-03-01

    This report reviews the current state of technology regarding hydrogen safety issues in light water reactor plants. Topics considered in this report relate to control systems and include combustion prevention, controlled combustion, minimization of combustion effects, combination of control concepts, and post-accident disposal. A companion report addresses hydrogen generation, distribution, and combustion. The objectives of the study were to identify the key safety issues related to hydrogen produced under severe accident conditions, to describe the state of technology for each issue, and to point out ongoing programs aimed at resolving the open issues.

  3. Study of light water reactor containments under important severe accident conditions

    SciTech Connect

    Hofmayer, C.H.; Pratt, W.T.; Bagchi, G.; Noonan, V.S.

    1985-01-01

    The US Nuclear Regulatory Commission has sponsored studies to develop a ''LEAKAGE-BEFORE-FAILURE'' model for use in severe accident risk assessments to provide a means of accounting for significant containment leakage prior to reaching the containment threshold pressure. Six containment types have been studied (large dry, subatmospheric, ice condenser, Mark I, II, and III). Potential leak paths through major containment penetration assemblies were investigated and upper-bound estimates of leak areas established. These leak areas may result from increasing internal pressure and degradation of nonmetallic seal materials due to severe accident conditions. This paper describes the approach and summarizes the results and conclusions of this study.

  4. PRESSURE INTEGRITY OF 3013 CONTAINER UNDER POSTULATED ACCIDENT CONDITIONS

    SciTech Connect

    Rawls, G.

    2010-02-01

    A series of tests was carried out to determine the threshold for deflagration-to-detonation transition (DDT), structural loading, and structural response of the Department of Energy 3013 storage systems for the case of an accidental explosion of evolved gas within the storage containers. Three experimental fixtures were used to examine the various issues and three mixtures consisting of either stoichiometric hydrogen-oxygen, stoichiometric hydrogen-oxygen with added nitrogen, or stoichiometric hydrogen-oxygen with an added nitrogen-helium mixture were tested. Tests were carried out as a function of initial pressure from 1 to 3.5 bar and initial temperature from room temperature to 150 C. The elevated temperature tests resulted in a slight increase in the threshold pressure for DDT. The elevated temperature tests were performed to ensure the test results were bounding. Because the change was not significant the elevated temperature data are not presented in the paper. The explosions were initiated with either a small spark or a hot surface. Based on the results of these tests under the conditions investigated, it can be concluded that DDT of a stoichiometric hydrogen-oxygen mixture (and mixtures diluted with nitrogen and helium) within the 3013 containment system does not pose a threat to the structural integrity of the outer container.

  5. [Endolymphatic sac adenocarcinoma: case report].

    PubMed

    Silveira, Roberto Leal; Gusmão, Sebastião Silva; Pittella, José Eymard H; Santos, Sinval Pereira

    2002-09-01

    A case of endolymphatic sac adenocarcinoma is reported and the literature is reviewed. The clinical picture was presented by vertigo and progressive hearing loss caused by a tumor of the endolymphatic sac. The surgical removal was complete, via a retro and translabyrinthine approach. Endolymphatic sac tumors are locally invasive, involve the petrous bone and the mastoid. The radical surgery presents good outcome.

  6. Assessment of potential doses to workers during postulated accident conditions at the Waste Isolation Pilot Plant

    SciTech Connect

    Hoover, M.D.; Farrell, R.F.; Newton, G.J.

    1995-12-01

    The recent 1995 WIPP Safety Analysis Report (SAR) Update provided detailed analyses of potential radiation doses to members of the public at the site boundary during postulated accident scenarios at the U.S. Department of Energy`s Waste Isolation Pilot Plant (WIPP). The SAR Update addressed the complete spectrum of potential accidents associated with handling and emplacing transuranic waste at WIPP, including damage to waste drums from fires, punctures, drops, and other disruptions. The report focused on the adequacy of the multiple layers of safety practice ({open_quotes}defense-in-depth{close_quotes}) at WIPP, which are designed to (1) reduce the likelihood of accidents and (2) limit the consequences of those accidents. The safeguards which contribute to defense-in-depth at WIPP include a substantial array of inherent design features, engineered controls, and administrative procedures. The SAR Update confirmed that the defense-in-depth at WIPP is adequate to assure the protection of the public and environment. As a supplement to the 1995 SAR Update, we have conducted additional analyses to confirm that these controls will also provide adequate protection to workers at the WIPP. The approaches and results of the worker dose assessment are summarized here. In conformance with the guidance of DOE Standard 3009-94, we emphasize that use of these evaluation guidelines is not intended to imply that these numbers constitute acceptable limits for worker exposures under accident conditions. However, in conjunction with the extensive safety assessment in the 1995 SAR Update, these results indicate that the Carlsbad Area Office strategy for the assessment of hazards and accidents assures the protection of workers, members of the public, and the environment.

  7. Causal Factors and Adverse Conditions of Aviation Accidents and Incidents Related to Integrated Resilient Aircraft Control

    NASA Technical Reports Server (NTRS)

    Reveley, Mary S.; Briggs, Jeffrey L.; Evans, Joni K.; Sandifer, Carl E.; Jones, Sharon Monica

    2010-01-01

    The causal factors of accidents from the National Transportation Safety Board (NTSB) database and incidents from the Federal Aviation Administration (FAA) database associated with loss of control (LOC) were examined for four types of operations (i.e., Federal Aviation Regulation Part 121, Part 135 Scheduled, Part 135 Nonscheduled, and Part 91) for the years 1988 to 2004. In-flight LOC is a serious aviation problem. Well over half of the LOC accidents included at least one fatality (80 percent in Part 121), and roughly half of all aviation fatalities in the studied time period occurred in conjunction with LOC. An adverse events table was updated to provide focus to the technology validation strategy of the Integrated Resilient Aircraft Control (IRAC) Project. The table contains three types of adverse conditions: failure, damage, and upset. Thirteen different adverse condition subtypes were gleaned from the Aviation Safety Reporting System (ASRS), the FAA Accident and Incident database, and the NTSB database. The severity and frequency of the damage conditions, initial test conditions, and milestones references are also provided.

  8. Estimate of radionuclide release characteristics into containment under severe accident conditions. Final report

    SciTech Connect

    Nourbakhsh, H.P.

    1993-11-01

    A detailed review of the available light water reactor source term information is presented as a technical basis for development of updated source terms into the containment under severe accident conditions. Simplified estimates of radionuclide release and transport characteristics are specified for each unique combination of the reactor coolant and containment system combinations. A quantitative uncertainty analysis in the release to the containment using NUREG-1150 methodology is also presented.

  9. Shipping container response to severe highway and railway accident conditions: Appendices

    SciTech Connect

    Fischer, L.E.; Chou, C.K.; Gerhard, M.A.; Kimura, C.Y.; Martin, R.W.; Mensing, R.W.; Mount, M.E.; Witte, M.C.

    1987-02-01

    Volume 2 contains the following appendices: Severe accident data; truck accident data; railroad accident data; highway survey data and bridge column properties; structural analysis; thermal analysis; probability estimation techniques; and benchmarking for computer codes used in impact analysis. (LN)

  10. The Fuel Accident Condition Simulator (FACS) furnace system for high temperature performance testing of VHTR fuel

    SciTech Connect

    Paul A. Demkowicz; David V. Laug; Dawn M. Scates; Edward L. Reber; Lyle G. Roybal; John B. Walter; Jason M. Harp; Robert N. Morris

    2012-10-01

    The AGR-1 irradiation of TRISO-coated particle fuel specimens was recently completed and represents the most successful such irradiation in US history, reaching peak burnups of greater than 19% FIMA with zero failures out of 300,000 particles. An extensive post-irradiation examination (PIE) campaign will be conducted on the AGR-1 fuel in order to characterize the irradiated fuel properties, assess the in-pile fuel performance in terms of coating integrity and fission metals release, and determine the fission product retention behavior during high temperature safety testing. A new furnace system has been designed, built, and tested to perform high temperature accident tests. The Fuel Accident Condition Simulator furnace system is designed to heat fuel specimens at temperatures up to 2000 degrees C in helium while monitoring the release of volatile fission metals (e.g. Cs, Ag, Sr, and Eu), iodine, and fission gases (Kr, Xe). Fission gases released from the fuel to the sweep gas are monitored in real time using dual cryogenic traps fitted with high purity germanium detectors. Condensable fission products are collected on a plate attached to a water-cooled cold finger that can be exchanged periodically without interrupting the test. Analysis of fission products on the condensation plates involves dry gamma counting followed by chemical analysis of selected isotopes. This paper will describe design and operational details of the Fuel Accident Condition Simulator furnace system and the associated fission gas monitoring system, as well as preliminary system calibration results.

  11. Fission products behaviour in UO2 submitted to nuclear severe accident conditions

    NASA Astrophysics Data System (ADS)

    Geiger, E.; Bès, R.; Martin, P.; Pontillon, Y.; Solari, P. L.; Salome, M.

    2016-05-01

    The objective of this work was to study the molybdenum chemistry in UO2 based materials, known as SIMFUELS. These materials could be used as an alternative to irradiated nuclear fuels in the study of fission products behaviour during a nuclear severe accident. UO2 samples doped with 12 stable isotopes of fission products were submitted to annealing tests in conditions representative to intermediate steps of severe accidents. Samples were characterized by SEM-EDS and XAS. It was found that Mo chemistry seems to be more complex than what is normally estimated by thermodynamic calculations: XAS spectra indicate the presence of Mo species such as metallic Mo, MoO2, MoO3 and Cs2MoO4.

  12. a Study of the Interferences with the On-Line Radioiodine Measurement Under Nuclear Accident Conditions

    NASA Astrophysics Data System (ADS)

    Tseng, Tung-Tse

    In this research the interferences with the on -line detection of radioiodines, under nuclear accident conditions, were studied. The special tool employed for this research is the developed on-line radioiodine monitor (the Penn State Radioiodine Monitor), which is capable of detecting low levels of radioiodine on-line in air containing orders of magnitude higher levels of radioactive noble gases. Most of the data reported in this thesis were collected during a series of experiments called "Source -Term Experiment Program (STEP)." The experiments were conducted at the Argonne National Laboratory's TREAT reactor located at the Idaho National Engineering Laboratory (INEL). In these tests, fission products were released from the Light Water Reactor (LWR) test fuels as a result of simulating a reactor accident. The Penn State Monitor was then used to sample the fission products accumulated in a large container which simulated the reactor containment building. The test results proved that the Penn State Monitor was not affected significantly by the passage of large amounts of noble gases through the system. Also, it confirmed the predicted results that the operation of conventional on-line radioiodine detectors would, under nuclear accident conditions, be seriously impaired by the passage of high concentrations of radioactive noble gases through such systems. This work also demonstrated that under conditions of high noble gas concentrations and low radioiodine concentrations, the formation of noble-gas-decayed alkali metals can seriously interfere with the on-line detection of radioiodine, especially during the 24 hours immediately after the accident. The decayed alkali metal particulates were also found to be much more penetrating than the ordinary type of particulates, since a large fraction (15%) of the particulates were found to penetrate through the commonly used High Efficiency Particulate Air (HEPA) filter (rated >99.97% for 0.3 (mu)m particulate). Also, a

  13. Analysis 320 coal mine accidents using structural equation modeling with unsafe conditions of the rules and regulations as exogenous variables.

    PubMed

    Zhang, Yingyu; Shao, Wei; Zhang, Mengjia; Li, Hejun; Yin, Shijiu; Xu, Yingjun

    2016-07-01

    Mining has been historically considered as a naturally high-risk industry worldwide. Deaths caused by coal mine accidents are more than the sum of all other accidents in China. Statistics of 320 coal mine accidents in Shandong province show that all accidents contain indicators of "unsafe conditions of the rules and regulations" with a frequency of 1590, accounting for 74.3% of the total frequency of 2140. "Unsafe behaviors of the operator" is another important contributory factor, which mainly includes "operator error" and "venturing into dangerous places." A systems analysis approach was applied by using structural equation modeling (SEM) to examine the interactions between the contributory factors of coal mine accidents. The analysis of results leads to three conclusions. (i) "Unsafe conditions of the rules and regulations," affect the "unsafe behaviors of the operator," "unsafe conditions of the equipment," and "unsafe conditions of the environment." (ii) The three influencing factors of coal mine accidents (with the frequency of effect relation in descending order) are "lack of safety education and training," "rules and regulations of safety production responsibility," and "rules and regulations of supervision and inspection." (iii) The three influenced factors (with the frequency in descending order) of coal mine accidents are "venturing into dangerous places," "poor workplace environment," and "operator error."

  14. Analysis 320 coal mine accidents using structural equation modeling with unsafe conditions of the rules and regulations as exogenous variables.

    PubMed

    Zhang, Yingyu; Shao, Wei; Zhang, Mengjia; Li, Hejun; Yin, Shijiu; Xu, Yingjun

    2016-07-01

    Mining has been historically considered as a naturally high-risk industry worldwide. Deaths caused by coal mine accidents are more than the sum of all other accidents in China. Statistics of 320 coal mine accidents in Shandong province show that all accidents contain indicators of "unsafe conditions of the rules and regulations" with a frequency of 1590, accounting for 74.3% of the total frequency of 2140. "Unsafe behaviors of the operator" is another important contributory factor, which mainly includes "operator error" and "venturing into dangerous places." A systems analysis approach was applied by using structural equation modeling (SEM) to examine the interactions between the contributory factors of coal mine accidents. The analysis of results leads to three conclusions. (i) "Unsafe conditions of the rules and regulations," affect the "unsafe behaviors of the operator," "unsafe conditions of the equipment," and "unsafe conditions of the environment." (ii) The three influencing factors of coal mine accidents (with the frequency of effect relation in descending order) are "lack of safety education and training," "rules and regulations of safety production responsibility," and "rules and regulations of supervision and inspection." (iii) The three influenced factors (with the frequency in descending order) of coal mine accidents are "venturing into dangerous places," "poor workplace environment," and "operator error." PMID:27085591

  15. Status report of advanced cladding modeling work to assess cladding performance under accident conditions

    SciTech Connect

    B.J. Merrill; Shannon M. Bragg-Sitton

    2013-09-01

    Scoping simulations performed using a severe accident code can be applied to investigate the influence of advanced materials on beyond design basis accident progression and to identify any existing code limitations. In 2012 an effort was initiated to develop a numerical capability for understanding the potential safety advantages that might be realized during severe accident conditions by replacing Zircaloy components in light water reactors (LWRs) with silicon carbide (SiC) components. To this end, a version of the MELCOR code, under development at the Sandia National Laboratories in New Mexico (SNL/NM), was modified by replacing Zircaloy for SiC in the MELCOR reactor core oxidation and material properties routines. The modified version of MELCOR was benchmarked against available experimental data to ensure that present SiC oxidation theory in air and steam were correctly implemented in the code. Additional modifications have been implemented in the code in 2013 to improve the specificity in defining components fabricated from non-standard materials. An overview of these modifications and the status of their implementation are summarized below.

  16. Role of Winter Weather Conditions and Slipperiness on Tourists' Accidents in Finland.

    PubMed

    Lépy, Élise; Rantala, Sinikka; Huusko, Antti; Nieminen, Pentti; Hippi, Marjo; Rautio, Arja

    2016-01-01

    (1) BACKGROUND: In Finland, slippery snowy or icy ground surface conditions can be quite hazardous to human health during wintertime. We focused on the impacts of the variability in weather conditions on tourists' health via documented accidents during the winter season in the Sotkamo area. We attempted to estimate the slipping hazard in a specific context of space and time focusing on the weather and other possible parameters, responsible for fluctuations in the numbers of injuries/accidents; (2) METHODS: We used statistical distributions with graphical illustrations to examine the distribution of visits to Kainuu Hospital by non-local patients and their characteristics/causes; graphs to illustrate the distribution of the different characteristics of weather conditions; questionnaires and interviews conducted among health care and safety personnel in Sotkamo and Kuusamo; (3) RESULTS: There was a clear seasonal distribution in the numbers and types of extremity injuries of non-local patients. While the risk of slipping is emphasized, other factors leading to injuries are evaluated; and (4) CONCLUSIONS: The study highlighted the clear role of wintery weather conditions as a cause of extremity injuries even though other aspects must also be considered. Future scenarios, challenges and adaptive strategies are also discussed from the viewpoint of climate change. PMID:27537899

  17. Role of Winter Weather Conditions and Slipperiness on Tourists’ Accidents in Finland

    PubMed Central

    Lépy, Élise; Rantala, Sinikka; Huusko, Antti; Nieminen, Pentti; Hippi, Marjo; Rautio, Arja

    2016-01-01

    (1) Background: In Finland, slippery snowy or icy ground surface conditions can be quite hazardous to human health during wintertime. We focused on the impacts of the variability in weather conditions on tourists’ health via documented accidents during the winter season in the Sotkamo area. We attempted to estimate the slipping hazard in a specific context of space and time focusing on the weather and other possible parameters, responsible for fluctuations in the numbers of injuries/accidents; (2) Methods: We used statistical distributions with graphical illustrations to examine the distribution of visits to Kainuu Hospital by non-local patients and their characteristics/causes; graphs to illustrate the distribution of the different characteristics of weather conditions; questionnaires and interviews conducted among health care and safety personnel in Sotkamo and Kuusamo; (3) Results: There was a clear seasonal distribution in the numbers and types of extremity injuries of non-local patients. While the risk of slipping is emphasized, other factors leading to injuries are evaluated; and (4) Conclusions: The study highlighted the clear role of wintery weather conditions as a cause of extremity injuries even though other aspects must also be considered. Future scenarios, challenges and adaptive strategies are also discussed from the viewpoint of climate change. PMID:27537899

  18. Hypothetical accident condition thermal analysis and testing of a Type B drum package

    SciTech Connect

    Hensel, S.J.; Alstine, M.N. Van; Gromada, R.J.

    1995-07-01

    A thermophysical property model developed to analytically determine the thermal response of cane fiberboard when exposed to temperatures and heat fluxes associated with the 10 CFR 71 hypothetical accident condition (HAC) has been benchmarked against two Type B drum package fire test results. The model 9973 package was fire tested after a 30 ft. top down drop and puncture, and an undamaged model 9975 package containing a heater (21W) was fire tested to determine content heat source effects. Analysis results using a refined version of a previously developed HAC fiberboard model compared well against the test data from both the 9973 and 9975 packages.

  19. A radioactive waste transportation package monitoring system for normal transport and accident emergency response conditions

    SciTech Connect

    Brown, G. S.; Cashwell, J. W.; Apple, M. L.

    1991-01-01

    Shipments of radioactive material (RAM) constitute but a small fraction of the total hazardous materials shipped in the United States each year. Public perception, however, of the potential consequences of a release from a transportation package containing RAM has resulted in significant regulation of transport operations, both to ensure the integrity of a package in accident conditions and to place operational constraints on the shipper. Much of this attention has focused on shipments of spent nuclear fuel and high level wastes which, although comprising a very small number of total shipments, constitute a majority of the total curies transported on an annual basis. This report discusses the shipment of these highly radioactive materials.

  20. DYNAMIC ANALYSIS OF HANFORD UNIRRADIATED FUEL PACKAGE SUBJECTED TO SEQUENTIAL LATERAL LOADS IN HYPOTHETICAL ACCIDENT CONDITIONS

    SciTech Connect

    Wu, T

    2008-04-30

    Large fuel casks present challenges when evaluating their performance in the Hypothetical Accident Conditions (HAC) specified in the Code of Federal Regulations Title 10 part 71 (10CFR71). Testing is often limited by cost, difficulty in preparing test units and the limited availability of facilities which can carry out such tests. In the past, many casks were evaluated without testing by using simplified analytical methods. This paper presents a numerical technique for evaluating the dynamic responses of large fuel casks subjected to sequential HAC loading. A nonlinear dynamic analysis was performed for a Hanford Unirradiated Fuel Package (HUFP) [1] to evaluate the cumulative damage after the hypothetical accident Conditions of a 30-foot lateral drop followed by a 40-inch lateral puncture as specified in 10CFR71. The structural integrity of the containment vessel is justified based on the analytical results in comparison with the stress criteria, specified in the ASME Code, Section III, Appendix F [2], for Level D service loads. The analyzed cumulative damages caused by the sequential loading of a 30-foot lateral drop and a 40-inch lateral puncture are compared with the package test data. The analytical results are in good agreement with the test results.

  1. Experimental results from containment piping bellows subjected to severe accident conditions: Results from bellows tested in corroded conditions. Volume 2

    SciTech Connect

    Lambert, L.D.; Parks, M.B.

    1995-10-01

    Bellows are an integral part of the containment pressure boundary in nuclear power plants. They are used at piping penetrations to allow relative movement between piping and the containment wall, while minimizing the load imposed on the piping and wall. Piping bellows are primarily used in steel containments; however, they have received limited use in some concrete (reinforced and prestressed) containments. In a severe accident they may be subjected to pressure and temperature conditions that exceed the design values, along with a combination of axial and lateral deflections. A test program to determine the leak-tight capacity of containment penetration bellows is being conducted at Sandia National Laboratories under the sponsorship of the US Nuclear Regulatory Commission. Several different bellows geometries, representative of actual containment bellows, have been subjected to extreme deflections along with pressure and temperature loads. The bellows geometries and loading conditions are described along with the testing apparatus and procedures. A total of nineteen bellows have been tested. Thirteen bellows were tested in ``like-new`` condition (results reported in Volume 1), and six were tested in a corroded condition. The tests showed that bellows in ``like-new`` condition are capable of withstanding relatively large deformations, up to, or near, the point of full compression or elongation, before developing leakage, while those in a corroded condition did not perform as well, depending on the amount of corrosion. The corroded bellows test program and results are presented in this report.

  2. Oxidation of SiC cladding under Loss of Coolant Accident (LOCA) conditions in LWRs

    SciTech Connect

    Lee, Y.; Yue, C.; Arnold, R. P.; McKrell, T. J.; Kazimi, M. S.

    2012-07-01

    An experimental assessment of Silicon Carbide (SiC) cladding oxidation rate in steam under conditions representative of Loss of Coolant Accidents (LOCA) in light water reactors (LWRs) was conducted. SiC oxidation tests were performed with monolithic alpha phase tubular samples in a vertical quartz tube at a steam temperature of 1140 deg. C and steam velocity range of 1 to 10 m/sec, at atmospheric pressure. Linear weight loss of SiC samples due to boundary layer controlled reaction of silica scale (SiO{sub 2} volatilization) was experimentally observed. The weight loss rate increased with increasing steam flow rate. Over the range of test conditions, SiC oxidation rates were shown to be about 3 orders of magnitude lower than the oxidation rates of zircaloy 4. A SiC volatilization correlation for developing laminar flow in a vertical channel is formulated. (authors)

  3. Containment performance of prototypical reactor containments subjected to severe accident conditions

    SciTech Connect

    Klamerus, E.W.; Bohn, M.P.; Wesley, D.A.; Krishnaswamy, C.N.

    1996-12-01

    In SECY-90-016, the NTRC proposed a safety goal of a conditional containment failure probability (CCFP) of 0.1 and the alternative acceptance criteria allowed for steel containments, which specifies that the stresses should not exceed ASNE Level C allowables for severe accident pressures and temperatures. In this work, the need for an equivalent criterion for concrete containments was studied. Six surrogate containments were designed and analyzed in order to compare the margins between design pressure, pressure resulting in exceedance of Level C (or yield) stress limits, and ultimate pressure. For comparability, each containment has an identical internal volume and design pressure. Results from the analysis showed margins to yield are comparable and display a similar margin for both steel and concrete containments. In addition, the margin to failure, although slightly higher in the steel containments, were also comparable. Finally, a CCFP for code design was determined based on general membrane behavior and imposing an upper bound severe accident curve developed in the DCH studies. The resulting CCFP`s were less then 0.02 (or 2%) for all the surrogate containments studied, showing that these containment designs all achieved the NRC safety goal.

  4. Insights on fission products behaviour in nuclear severe accident conditions by X-ray absorption spectroscopy

    NASA Astrophysics Data System (ADS)

    Geiger, E.; Bès, R.; Martin, Ph; Pontillon, Y.; Ducros, G.; Solari, P. L.

    2016-04-01

    Many research programs have been carried out aiming to understand the fission products behaviour during a Nuclear Severe Accident. Most of these programs used highly radioactive irradiated nuclear fuel, which requires complex instrumentation. Moreover, the radioactive character of samples hinders an accurate chemical characterisation. In order to overcome these difficulties, SIMFUEL stand out as an alternative to perform complementary tests. A sample made of UO2 doped with 11 fission products was submitted to an annealing test up to 1973 K in reducing atmosphere. The sample was characterized before and after the annealing test using SEM-EDS and XAS at the MARS beam-line, SOLEIL Synchrotron. It was found that the overall behaviour of several fission products (such as Mo, Ba, Pd and Ru) was similar to that observed experimentally in irradiated fuels and consistent with thermodynamic estimations. The experimental approach presented in this work has allowed obtaining information on chemical phases evolution under nuclear severe accident conditions, that are yet difficult to obtain using irradiated nuclear fuel samples.

  5. Neutronics and Fuel Performance Evaluation of Accident Tolerant Fuel under Normal Operation Conditions

    SciTech Connect

    Xu Wu; Piyush Sabharwall; Jason Hales

    2014-07-01

    This report details the analysis of neutronics and fuel performance analysis for enhanced accident tolerance fuel, with Monte Carlo reactor physics code Serpent and INL’s fuel performance code BISON, respectively. The purpose is to evaluate two of the most promising candidate materials, FeCrAl and Silicon Carbide (SiC), as the fuel cladding under normal operating conditions. Substantial neutron penalty is identified when FeCrAl is used as monolithic cladding for current oxide fuel. From the reactor physics standpoint, application of the FeCrAl alloy as coating layer on surface of zircaloy cladding is possible without increasing fuel enrichment. Meanwhile, SiC brings extra reactivity and the neutron penalty is of no concern. Application of either FeCrAl or SiC could be favorable from the fuel performance standpoint. Detailed comparison between monolithic cladding and hybrid cladding (cladding + coating) is discussed. Hybrid cladding is more practical based on the economics evaluation during the transition from current UO2/zircaloy to Accident Tolerant Fuel (ATF) system. However, a few issues remain to be resolved, such as the creep behavior of FeCrAl, coating spallation, inter diffusion with zirconium, etc. For SiC, its high thermal conductivity, excellent creep resistance, low thermal neutron absorption cross section, irradiation stability (minimal swelling) make it an excellent candidate materials for future nuclear fuel/cladding system.

  6. Nuclear waste shipping container response to severe accident conditions, A brief critique of the modal study

    SciTech Connect

    Audin, L.

    1990-12-01

    The Modal Study (NUREG/CR-4829) attempts to upgrade the analysis of spent nuclear fuel transportation accidents, and to verify the validity of the present regulatory scheme of cask performance standards as a means to minimize risk. While an improvement over many prior efforts in this area (such as NUREG-0170), it unfortunately fails to create a realistic simulation either of a shipping cask, the severe conditions to which it could be subjected, or the potential damage to the spent fuel cargo during an accident. There are too many deficiencies in its analysis to allow acceptance of its results for the presumed cask design, and many pending changes in new containers, cargoes and shipping patterns will limit applicability of the Modal Study to future shipments. In essence, the Modal Study is a good start, but is too simplistic, incomplete, outdated and open to serious question to be used as the basis for any present-day environmental or risk assessment of spent fuel transportation. It needs to be redone, with peer review during its production and experimental verification of its assumptions, before it has any relevance to the shipments planned to Yucca Mountain. Finally, it must be expanded into a full risk assessment by inputing its radiological release fractions and probabilities into a valid dispersal simulation to properly determine the impact of its results. 51 refs.

  7. Thermal analysis of the 10-gallon and the 55-gallon DOT-6M containers with thermal boundary conditions corresponding to 10CFR71 normal transport and accident conditions

    SciTech Connect

    Sanchez, L.C.; Longenbaugh, R.S.; Moss, M.; Haseman, G.M.; Fowler, W.E.; Roth, E.P.

    1988-03-01

    This report describes the heat transfer analysis of the 10-gallon and 55-gallon 6M containers. The analysis was performed with boundary conditions corresponding to a normal transport condition and a hypothetical accident condition. Computational results indicated that the insulation material in the 6M containers will adequately protect the payload region of the 6M containers. 26 refs., 26 figs., 8 tabs.

  8. Development of yolk sac inversion in Galea spixii and Cavia porcellus (Rodentia, Caviidae).

    PubMed

    de Oliveira, M F; do Vale, A M; Favaron, P O; Vasconcelos, B G; de Oliveira, G B; Miglino, M A; Mess, A

    2012-10-01

    Caviomorph development includes an inverted yolk sac. Since principle processes are not understood, we investigated its differentiation in Galea and re-examined material from the guinea pig. Galea showed the typical caviomorph conditions in blastocyst development and the nature of the definitive yolk sac, formed of the visceral layer that became villous, proliferative, vascularized and attached to the uterus and placenta. In contrast to what was known before, in both species parts of the parietal yolk sac and a yolk sac cavity were temporarily present. Data suggest that early yolk sac development in caviomorphs is more complex than thought before.

  9. Experiments to evaluate behavior of containment piping bellows under severe accident conditions

    SciTech Connect

    Lambert, L.D.; Parks, M.B.

    1993-11-01

    Bellows are an integral part of the containment pressure boundary in nuclear power plants. They are used at piping penetrations to allow relative movement between piping and the containment wall. In a severe accident they may be subjected to high pressure and temperature, and a combination of axial and lateral deflections. A test program to determine the leak-tight capacity of containment penetration bellows is being conducted at Sandia National Laboratories, Albuquerque, New Mexico. Several different bellows geometries, representative of actual containment bellows, are being subjected to extreme deflections along with pressure and temperature loads. The bellows geometries and loading conditions are described along with the testing apparatus and procedures. A total of thirteen tests have been conducted. The tests showed that withstanding relatively large bellows are capable of deformations, up to, or near, the point of full compression before developing leakage. The test data is presented and discussed.

  10. Radioactive particulate release associated with the DOT specification 6M container under hypothetical accident conditions

    SciTech Connect

    Taylor, J.M.; Raney, P.J.

    1986-02-01

    A testing program was conducted to determine the leakage of depleted uranium dioxide powder (DUO) from the inner containment components of the US Department of Transportation's (DOT) specification 6M container under hypothetical accident conditions. Depleted uranium dioxide was selected as a surrogate for plutonium oxide because of the similarities in the powder characteristics, density and particle size, and because of the special handling and special facilities required for plutonium oxide. The DUO was packaged inside food pack cans in three different configurations inside the 2R vessel of the 6M container. The amount of DUO powder leakage ranged from none detectable (<2 x 10/sup -7/ g) to a high of 1 x 10/sup -3/ g. The combination of gravity, vibration and pressure produced the highest leakage of DUO. Containers that had hermetic seals (leak rates <6 x 10/sup -4/ atm cc/min) did not leak any detectable amount (<2 x 10/sup -7/ g) of DUO under the test conditions. Impact forces had no effect on the leakage of particles with the packaging configurations used. 23 refs., 24 figs., 3 tabs.

  11. Haemangiopericytoma of the lacrimal sac.

    PubMed

    Watanabe, Akihide; Wu, Albert; Sun, Michelle T; Inatani, Masaru; Katori, Nobutada; Selva, Dinesh

    2016-08-01

    Haemangiopericytomas (HPCs) are rare tumours which infrequently occur in the lacrimal sac. Only 8 cases of lacrimal sac HPC have previously been reported. The authors report 2 additional cases presenting clinically with epiphora and a mass. One case recurred 3 times during an 18-year period. The other case did not recur during 51 months of follow-up. The tumours showed immunohistochemical features consistent with a diagnosis of HPC. The authors recommend wide excision for these tumours and careful long-term follow-up to detect recurrence which is not uncommon. PMID:27322416

  12. Generation IV benchmarking of TRISO fuel performance models under accident conditions. Modeling input data

    SciTech Connect

    Blaise Collin

    2014-09-01

    This document presents the benchmark plan for the calculation of particle fuel performance on safety testing experiments that are representative of operational accidental transients. The benchmark is dedicated to the modeling of fission product release under accident conditions by fuel performance codes from around the world, and the subsequent comparison to post-irradiation experiment (PIE) data from the modeled heating tests. The accident condition benchmark is divided into three parts: the modeling of a simplified benchmark problem to assess potential numerical calculation issues at low fission product release; the modeling of the AGR-1 and HFR-EU1bis safety testing experiments; and, the comparison of the AGR-1 and HFR-EU1bis modeling results with PIE data. The simplified benchmark case, thereafter named NCC (Numerical Calculation Case), is derived from ''Case 5'' of the International Atomic Energy Agency (IAEA) Coordinated Research Program (CRP) on coated particle fuel technology [IAEA 2012]. It is included so participants can evaluate their codes at low fission product release. ''Case 5'' of the IAEA CRP-6 showed large code-to-code discrepancies in the release of fission products, which were attributed to ''effects of the numerical calculation method rather than the physical model''[IAEA 2012]. The NCC is therefore intended to check if these numerical effects subsist. The first two steps imply the involvement of the benchmark participants with a modeling effort following the guidelines and recommendations provided by this document. The third step involves the collection of the modeling results by Idaho National Laboratory (INL) and the comparison of these results with the available PIE data. The objective of this document is to provide all necessary input data to model the benchmark cases, and to give some methodology guidelines and recommendations in order to make all results suitable for comparison with each other. The participants should read this document

  13. Thermochemistry of Ruthenium Oxyhydroxide Species and Their Impact on Volatile Speciations in Severe Nuclear Accident Conditions.

    PubMed

    Miradji, Faoulat; Virot, François; Souvi, Sidi; Cantrel, Laurent; Louis, Florent; Vallet, Valérie

    2016-02-01

    Literature thermodynamic data of ruthenium oxyhydroxides reveal large uncertainties in some of the standard enthalpies of formation, motivating the use of high-level relativistic correlated quantum chemical methods to reduce the level of discrepancies. Reaction energies leading to the formation of all possible oxyhydroxide species RuOx(OH)y(H2O)z have been calculated for a series of reactions combining DFT (TPSSh-5%HF) geometries and partition functions, CCSD(T) energies extrapolated to the complete basis set limits. The highly accurate ab initio thermodynamic data were used as input data of thermodynamic equilibrium computations to derive the speciation of gaseous ruthenium species in the temperature, pressure and concentration conditions of severe nuclear accidents occurring in pressurized water reactors. At temperatures lower than 1000 K, gaseous ruthenium tetraoxide is the dominating species, between 1000 and 2000 K ruthenium trioxide becomes preponderant, whereas at higher temperatures gaseous ruthenium oxide, dioxide and even Ru in gaseous phase are formed. Although earlier studies predicted the formation of oxyhydroxides in significant quantities, the use of highly accurate ab initio thermodynamic data for ruthenium gaseous species leads to a more reliable inventory of gaseous ruthenium species in which gaseous oxyhydroxide ruthenium molecules are formed only in negligible amounts.

  14. Thermochemistry of Ruthenium Oxyhydroxide Species and Their Impact on Volatile Speciations in Severe Nuclear Accident Conditions.

    PubMed

    Miradji, Faoulat; Virot, François; Souvi, Sidi; Cantrel, Laurent; Louis, Florent; Vallet, Valérie

    2016-02-01

    Literature thermodynamic data of ruthenium oxyhydroxides reveal large uncertainties in some of the standard enthalpies of formation, motivating the use of high-level relativistic correlated quantum chemical methods to reduce the level of discrepancies. Reaction energies leading to the formation of all possible oxyhydroxide species RuOx(OH)y(H2O)z have been calculated for a series of reactions combining DFT (TPSSh-5%HF) geometries and partition functions, CCSD(T) energies extrapolated to the complete basis set limits. The highly accurate ab initio thermodynamic data were used as input data of thermodynamic equilibrium computations to derive the speciation of gaseous ruthenium species in the temperature, pressure and concentration conditions of severe nuclear accidents occurring in pressurized water reactors. At temperatures lower than 1000 K, gaseous ruthenium tetraoxide is the dominating species, between 1000 and 2000 K ruthenium trioxide becomes preponderant, whereas at higher temperatures gaseous ruthenium oxide, dioxide and even Ru in gaseous phase are formed. Although earlier studies predicted the formation of oxyhydroxides in significant quantities, the use of highly accurate ab initio thermodynamic data for ruthenium gaseous species leads to a more reliable inventory of gaseous ruthenium species in which gaseous oxyhydroxide ruthenium molecules are formed only in negligible amounts. PMID:26789932

  15. Cul-de-Sac Kids

    ERIC Educational Resources Information Center

    Hochschild, Thomas R., Jr.

    2013-01-01

    Previous research indicates that adults who live on cul-de-sac streets are more likely to have positive experiences with neighbors than residents of other street types (Brown and Werner, 1985; Hochschild Jr, 2011; Mayo Jr, 1979; Willmott, 1963). The present research ascertains whether street design has an impact on children's neighborhood…

  16. Early results from an experimental program to determine the behavior of containment piping penetration bellows subjected to severe accident conditions

    SciTech Connect

    Lambert, L.D.; Parks, M.B.

    1994-09-01

    Containment piping penetration bellows are an integral part of the pressure boundary in steel containments in the United States (US). Their purpose is to minimize loading on the containment shell caused by differential movement between the piping and the containment. This differential movement is typically caused by thermal gradients generated during startup and shutdown of the reactor, but can be caused by earthquake, a loss-of-coolant accident (LOCA), or ``severe`` accidents. In the event of a severe accident, the bellows would be subjected to pressure, temperature, and deflection well beyond the design basis. Most bellows are installed such that they would be subjected to elevated internal pressure, elevated temperature, axial compression, and lateral deflection during a severe accident. A few bellows would be subjected to external pressure and axial elongation, as well as elevated temperature and lateral deflection. The purpose of this experimental program is to examine the potential for leakage of containment bellows during a severe accident. The test series subjects bellows to various levels and combinations of internal pressure, elevated temperature, axial compression or elongation, and lateral deformation. The experiments are being conducted in two parts. For Part 1, all bellows specimens are tested in ``like-new`` condition, without regard for the possible degrading effect of corrosion that has been observed in some containment piping bellows in the US Part I testing, which included 13 bellows tests, has been completed. The second part of the experimental program, in which bellows are subjected to simulated corrosive environments prior to testing, has just just begun. The Part I experiments have shown that bellows in ``like-new`` condition can withstand elevated temperatures and pressures along with large deformations before leaking. In most cases, the like-new bellows were fully compressed without developing any leakage.

  17. Mitigative techniques and analysis of generic site conditions for ground-water contamination associated with severe accidents

    SciTech Connect

    Shafer, J.M.; Oberlander, P.L.; Skaggs, R.L.

    1984-04-01

    The purpose of this study is to evaluate the feasibility of using ground-water contaminant mitigation techniques to control radionuclide migration following a severe commercial nuclear power reactor accident. The two types of severe commercial reactor accidents investigated are: (1) containment basemat penetration of core melt debris which slowly cools and leaches radionuclides to the subsurface environment, and (2) containment basemat penetration of sump water without full penetration of the core mass. Six generic hydrogeologic site classifications are developed from an evaluation of reported data pertaining to the hydrogeologic properties of all existing and proposed commercial reactor sites. One-dimensional radionuclide transport analyses are conducted on each of the individual reactor sites to determine the generic characteristics of a radionuclide discharge to an accessible environment. Ground-water contaminant mitigation techniques that may be suitable, depending on specific site and accident conditions, for severe power plant accidents are identified and evaluated. Feasible mitigative techniques and associated constraints on feasibility are determined for each of the six hydrogeologic site classifications. The first of three case studies is conducted on a site located on the Texas Gulf Coastal Plain. Mitigative strategies are evaluated for their impact on contaminant transport and results show that the techniques evaluated significantly increased ground-water travel times. 31 references, 118 figures, 62 tables.

  18. The anuran vocal sac: a tool for multimodal signalling.

    PubMed

    Starnberger, Iris; Preininger, Doris; Hödl, Walter

    2014-11-01

    Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems.

  19. The anuran vocal sac: a tool for multimodal signalling

    PubMed Central

    Starnberger, Iris; Preininger, Doris; Hödl, Walter

    2014-01-01

    Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

  20. The anuran vocal sac: a tool for multimodal signalling.

    PubMed

    Starnberger, Iris; Preininger, Doris; Hödl, Walter

    2014-11-01

    Although in anurans the predominant mode of intra- and intersexual communication is vocalization, modalities used in addition to or instead of acoustic signals range from seismic and visual to chemical. In some cases, signals of more than one modality are produced through or by the anuran vocal sac. However, its role beyond acoustics has been neglected for some time and nonacoustic cues such as vocal sac movement have traditionally been seen as an epiphenomenon of sound production. The diversity in vocal sac coloration and shape found in different species is striking and recently its visual properties have been given a more important role in signalling. Chemosignals seem to be the dominant communication mode in newts, salamanders and caecilians and certainly play a role in the aquatic life phase of anurans, but airborne chemical signalling has received less attention. There is, however, increasing evidence that at least some terrestrial anuran species integrate acoustic, visual and chemical cues in species recognition and mate choice and a few secondarily mute anuran species seem to fully rely on volatile chemical cues produced in glands on the vocal sac. Within vertebrates, frogs in particular are suitable organisms for investigating multimodal communication by means of experiments, since they are tolerant of disturbance by observers and can be easily manipulated under natural conditions. Thus, the anuran vocal sac might be of great interest not only to herpetologists, but also to behavioural biologists studying communication systems. PMID:25389375

  1. Assessment on Integrity of BWR Internals Against Impact Load by Water Hammer Under Conditions of Reactivity Initiated Accidents

    SciTech Connect

    Azuma, Mie; Taniguchi, Atsushi; Hotta, Akitoshi; Ohta, Takeshi

    2005-03-15

    The integrity of the reactor pressure vessel (RPV) head and reactor internals was assessed by means of fluid and fluid-structural coupled analyses to evaluate the water hammer phenomenon arising from postulated high burnup fuel failure under reactivity initiated accident (RIA) conditions. The fluid viscosity effect on the water column burst as well as the complex three-dimensional flow paths caused by a core shroud and standpipes were considered in this study. It is shown that fluid viscosity becomes an influential factor to dissipate impacting kinetic energy. Integrity of the RPV head and the shroud head was ensured with a sufficient level of margin even under these excessively conservative RIA conditions.

  2. Progress in the studies of passive heat removal in the next European torus under accident conditions

    SciTech Connect

    Soria, A. ); Renda, V.; Papa, L. . Joint Research Centre); Fenoglio, F. )

    1989-12-01

    Within the framework of safety analysis for the next European torus, a decay heat hazards assessment is under way in Ispra. Undercooling accidents (loss-of-coolant and loss-of-flow accidents (LOCAs and LOFAs)) due to pump failure have been investigated assuming an automatic plasma shutdown in both cases. The passive heat removal mechanisms considered include radiation between components and residual cooling by the thermosyphon effect in the main cooling circuits. Conservative thermohydraulic calculations have been made to determine coolant velocity and temperature transients to avoid water boiling int he circuits. Results show that during a LOFA, water boiling can be avoided provided that the water inertia is large enough, and material melting temperatures are not reached during a LOCA.

  3. Rehabilitation of living conditions in territories contaminated by the Chernobyl accident: the ETHOS project.

    PubMed

    Lochard, Jacques

    2007-11-01

    The ETHOS Project, supported by the radiation protection research program of the European Commission (EC), was implemented in the mid-1990's with the support of the Belarus authorities as a pilot project to initiate a new approach for the rehabilitation of living conditions in the contaminated territories of the Republic. This initiative followed a series of studies performed in the context of the EC Community of Independent States cooperation program to evaluate the consequences of the Chernobyl accident (1991-1995), which clearly brought to the fore that a salient characteristic of the situation in these territories was the progressive and general loss of control of the population on its daily life. Furthermore, due to the economic difficulties during the years following the breakdown of the USSR, the population was developing private production and, in the absence of know-how and adequate means to control the radiological quality of foodstuffs, the level of internal exposure was rising significantly. The aim of the project was primarily to involve directly the population wishing to stay in the territories in the day-to-day management of the radiological situation with the goal of improving their protection and their living conditions. It was based on clear ethical principles and implemented by an interdisciplinary team of European experts with specific skills in radiation protection, agronomy, social risk management, communication, and cooperation in complex situations, with the support of local authorities and professionals. In a first phase (1996-1999), the ETHOS Project was implemented in a village located in the Stolyn District in the southern part of Belarus. During this phase, a few tens of villagers were involved in a step-by-step evaluation of the local radiological situation to progressively regain control of their daily life. In a second phase (1999-2001), the ETHOS Project was extended to four other localities of the District with the objective to

  4. Computational Assessment of the GT-MHR Graphite Core Support Structural Integrity in Air-Ingress Accident Condition

    SciTech Connect

    Jong B. Lim; Eung S. Kim; Chang H. Oh; Richard R. Schultz; David A. Petti

    2008-10-01

    The objective of this project was to perform stress analysis for graphite support structures of the General Atomics’ 600 MWth GT-MHR prismatic core design using ABAQUS ® (ver. 6.75) to assess their structural integrity in air-ingress accident conditions where the structure weakens over time due to oxidation damages. The graphite support structures of prismatic type GT-MHR was analyzed based on the change of temperature, burn-off and corrosion depth during the accident period predicted by GAMMA, a multi-dimensional gas multi-component mixture analysis code developed in the Republic of Korea (ROK)/United States (US) International –Nuclear Engineering Research Initiative (I-NERI) project. Both the loading and thermal stresses were analyzed, but the thermal stress was not significant, leaving the loading stress to be the major factor. The mechanical strengths are exceeded between 11 to 11.5 days after loss-of-coolant-accident (LOCA), corresponding to 5.5 to 6 days after the start of natural convection.

  5. Core cooling under accident conditions at the high-flux beam reactor

    SciTech Connect

    Tichler, P.; Cheng, L. ); Fauske, H. )

    1991-01-01

    The High-Flux Beam Reactor (HFBR) at Brookhaven National Laboratory (BNL) is cooled and moderated by heavy water and contains {sup 235}U in the form of narrow-channel, parallel-plate-type fuel elements. During normal operation, the flow direction is downward through the core. This flow direction is maintained at a reduced flow rate during routine shutdown and on loss of commercial power by means of redundant pumps and power supplies. However, in certain accident scenarios, e.g. loss-of-coolant accidents (LOCAs), all forced-flow cooling is lost. Although there was experimental evidence during the reactor design period (1958-1963) that the heat removal capacity in the fully developed natural circulation cooling mode was relatively high, it was not possible to make a confident prediction of the heat removal capacity during the transition from downflow to natural circulation. Accordingly, a test program was initiated using an electrically heated section to simulate the fuel channel and a cooling loop to simulate the balance of the primary cooling system.

  6. Core cooling under accident conditions at the high flux beam reactor (HFBR)

    SciTech Connect

    Tichler, P.; Cheng, L. ); Fauske, H. )

    1991-01-01

    In certain accident scenarios, e.g. loss of coolant accidents (LOCA) all forced flow cooling is lost. Decay heating causes a temperature increase in the core coolant and the resulting thermal buoyancy causes a reversal of the flow direction to a natural circulation mode. Although there was experimental evidence during the reactor design period (1958--1963) that the heat removal capacity in the fully developed natural circulation cooling mode was relatively high, it was not possible to make a confident prediction of the heat removal capacity during the transition from downflow to natural circulation. In a LOCA scenario where even limited fuel damage occurs and natural circulation is established, fission product gases could be carried from the damaged fuel by steam into areas where operator access is required to maintain the core in a coolable configuration. This would force evacuation of the building and lead to extensive core damage. As a result the HFBR was shut down by the Department of Energy (DOE) and an extensive review of the HFBR was initiated. In an effort to address this issue BNL developed a model designed to predict the heat removal limit during flow reversal that was found to be in good agreement with the test results. Currently a thermal-hydraulic test program is being developed to provide a more realistic and defensible estimate of the flow reversal heat removal limit so that the reactor power level can be increased.

  7. Diagnostic imaging features of normal anal sacs in dogs and cats.

    PubMed

    Jung, Yechan; Jeong, Eunseok; Park, Sangjun; Jeong, Jimo; Choi, Ul Soo; Kim, Min-Su; Kim, Namsoo; Lee, Kichang

    2016-09-30

    This study was conducted to provide normal reference features for canine and feline anal sacs using ultrasound, low-field magnetic resonance imaging (MRI) and radiograph contrast as diagnostic imaging tools. A total of ten clinically normal beagle dogs and eight clinically normally cats were included. General radiography with contrast, ultrasonography and low-field MRI scans were performed. The visualization of anal sacs, which are located at distinct sites in dogs and cats, is possible with a contrast study on radiography. Most surfaces of the anal sacs tissue, occasionally appearing as a hyperechoic thin line, were surrounded by the hypoechoic external sphincter muscle on ultrasonography. The normal anal sac contents of dogs and cats had variable echogenicity. Signals of anal sac contents on low-field MRI varied in cats and dogs, and contrast medium using T1-weighted images enhanced the anal sac walls more obviously than that on ultrasonography. In conclusion, this study provides the normal features of anal sacs from dogs and cats on diagnostic imaging. Further studies including anal sac evaluation are expected to investigate disease conditions.

  8. Diagnostic imaging features of normal anal sacs in dogs and cats

    PubMed Central

    Jung, Yechan; Jeong, Eunseok; Park, Sangjun; Jeong, Jimo; Choi, Ul Soo; Kim, Min-Su; Kim, Namsoo

    2016-01-01

    This study was conducted to provide normal reference features for canine and feline anal sacs using ultrasound, low-field magnetic resonance imaging (MRI) and radiograph contrast as diagnostic imaging tools. A total of ten clinically normal beagle dogs and eight clinically normally cats were included. General radiography with contrast, ultrasonography and low-field MRI scans were performed. The visualization of anal sacs, which are located at distinct sites in dogs and cats, is possible with a contrast study on radiography. Most surfaces of the anal sacs tissue, occasionally appearing as a hyperechoic thin line, were surrounded by the hypoechoic external sphincter muscle on ultrasonography. The normal anal sac contents of dogs and cats had variable echogenicity. Signals of anal sac contents on low-field MRI varied in cats and dogs, and contrast medium using T1-weighted images enhanced the anal sac walls more obviously than that on ultrasonography. In conclusion, this study provides the normal features of anal sacs from dogs and cats on diagnostic imaging. Further studies including anal sac evaluation are expected to investigate disease conditions. PMID:26645338

  9. VICTORIA: A mechanistic model of radionuclide behavior in the reactor coolant system under severe accident conditions

    SciTech Connect

    Heames, T.J. ); Williams, D.A.; Johns, N.A.; Chown, N.M. ); Bixler, N.E.; Grimley, A.J. ); Wheatley, C.J. )

    1990-10-01

    This document provides a description of a model of the radionuclide behavior in the reactor coolant system (RCS) of a light water reactor during a severe accident. This document serves as the user's manual for the computer code called VICTORIA, based upon the model. The VICTORIA code predicts fission product release from the fuel, chemical reactions between fission products and structural materials, vapor and aerosol behavior, and fission product decay heating. This document provides a detailed description of each part of the implementation of the model into VICTORIA, the numerical algorithms used, and the correlations and thermochemical data necessary for determining a solution. A description of the code structure, input and output, and a sample problem are provided. The VICTORIA code was developed upon a CRAY-XMP at Sandia National Laboratories in the USA and a CRAY-2 and various SUN workstations at the Winfrith Technology Centre in England. 60 refs.

  10. Formation and characterization of fission-product aerosols under postulated HTGR accident conditions

    SciTech Connect

    Tang, I.N.; Munkelwitz, H.R.

    1982-07-01

    The paper presents the results of an experimental investigation on the formation mechanism and physical characterization of simulated nuclear aerosols that could likely be released during an HTGR core heat-up accident. Experiments were carried out in a high-temperature flow system consisting essentially of an inductively heated release source, a vapor deposition tube, and a filter assembly for collecting particulate matter. Simulated fission products Sr and Ba as oxides are separately impregnated in H451 graphite wafers and released at elevated temperatures into a dry helium flow. In the presence of graphite, the oxides are quantitatively reduced to metals, which subsequently vaporize at temperatures much lower than required for the oxides alone to vaporize in the absence of graphite. A substantial fraction of the released material is associated with particulate matter, which is collected on filters located downstream at ambient temperature. The release and transport of simulated fission product Ag as metal are also investigated.

  11. Health conditions among workers who participated in the cleanup of the Chernobyl accident.

    PubMed

    Kamarli, Z; Abdulina, A

    1996-01-01

    People who took part in the Chernobyl accident cleanup have been registered upon their return to Kyrgyzstan since 1991, and their children since 1992. Later, citizens affected by the Semipalatinsk and Chelyabinsk contamination incidents were included for registration and health care purposes. The effects of the nuclear waste depositories in the Mailuu-Suu region were examined with the assistance of the Kansas University Medical Center (United States of America). All these investigations of affected people indicate apparent increases in a number of symptoms and illnesses when compared to the rest of the population. Sample sizes ranged from several hundred to several thousand. Above-normal radiation levels and/or the stress and fear of living in contaminated area can lead to significant increases in nervous disorders, cardiovascular diseases and other problems. The most significant increase was in the suicide rate.

  12. Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals

    PubMed Central

    Tresguerres, Martin; Barott, Katie L.; Barron, Megan E.; Roa, Jinae N.

    2014-01-01

    Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3−, and sAC has been confirmed to be a HCO3− sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3−-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H+ absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved. PMID:24574382

  13. Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.

    PubMed

    Tresguerres, Martin; Barott, Katie L; Barron, Megan E; Roa, Jinae N

    2014-03-01

    Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3(-), and sAC has been confirmed to be a HCO3(-) sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3(-)-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H(+) absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved. PMID:24574382

  14. Study of Air Ingress Across the Duct During the Accident Conditions

    SciTech Connect

    Hassan, Yassin

    2013-05-06

    The goal of this project is to study the fundamental physical phenomena associated with air ingress in very high temperature reactors (VHTRs). Air ingress may occur due to a rupture of primary piping and a subsequent breach in the primary pressure boundary in helium-cooled and graphite-moderated VHTRs. Significant air ingress is a concern because it introduces potential to expose the fuel, graphite support rods, and core to a risk of severe graphite oxidation. Two of the most probable air ingress scenarios involve rupture of a control rod or fuel access standpipe, and rupture in the main coolant pipe on the lower part of the reactor pressure vessel. Therefore, establishing a fundamental understanding of air ingress phenomena is critical in order to rationally evaluate safety of existing VHTRs and develop new designs that minimize these risks. But despite this importance, progress toward development these predictive capabilities has been slowed by the complex nature of the underlying phenomena. The combination of inter-diffusion among multiple species, molecular diffusion, natural convection, and complex geometries, as well as the multiple chemical reactions involved, impose significant roadblocks to both modeling and experiment design. The project team will employ a coordinated experimental and computational effort that will help gain a deeper understanding of multiphased air ingress phenomena. This project will enhance advanced modeling and simulation methods, enabling calculation of nuclear power plant transients and accident scenarios with a high degree of confidence. The following are the project tasks: Perform particle image velocimetry measurement of multiphase air ingresses; and, Perform computational fluid dynamics analysis of air ingress phenomena.

  15. Recent condition of Fukushima-Daiichi nuclear plant accident in Japan

    NASA Astrophysics Data System (ADS)

    Ohnishi, Takeo

    2012-07-01

    Japanese government pronounced that the second step had been succeeded in the cooling down of the reactors on the middle of Dec 2011 at Fukushima-Daiichi nuclear power plant. In future, government aims to take out fuels from 4 reactors and shields their units. The nuclear power plants in Japan are gradually decreasing, because the checking for them has been performed and the permission of the re-start of them are difficult to be gained. On January 1st 2012, only 7 units are operating in Japan, though the about 54 units were set before the accident. At the end of December 2011, most radiations are emitted from cesium. The radioactivity in air and land around the plant was daily reported in newspaper. Government often gave the information about some RI-contamination in foods. They were taken off from the markets. At now stage, the most important project is the decontamination of radioactive materials from houses, schools, public facilities and industries. Government will newly classify three evacuation areas from April 2012. At the end of March, evacuees under 20 mSv/year possibly can go back their homes (evacuation-free area). The environmental doses will be depressed by decontamination under 10 mSv/year. At the range of 20-50 mSv, people will be controlled to live these area, they can go back their houses temporally (evacuation area). Over 50 mSv/year, however, people can go back house until 5 years at least (prohibited area). In new radiation limitation for a risk of human health, government made 100 mSv and 20 mSv for life span for one year, respectively. The aim of decontamination was set up to 10 mSv for 1 year and 5 mSv for next stage. A target at school is under1 mSv for children. Government accepted a new severe limitation per1 Kg at four groups; milk of baby (100 Bq) and milk (100 Bq), drinking water (10 Bq) and food (100 Bq). Tokyo electric Power Company and government should pay the sufficient compensation to evacuees. In future, they should keep health

  16. SACS: Spitzer Archival Cluster Survey

    NASA Astrophysics Data System (ADS)

    Stern, Daniel

    Emerging from the cosmic web, galaxy clusters are the most massive gravitationally bound structures in the universe. Thought to have begun their assembly at z > 2, clusters provide insights into the growth of large-scale structure as well as the physics that drives galaxy evolution. Understanding how and when the most massive galaxies assemble their stellar mass, stop forming stars, and acquire their observed morphologies in these environments remain outstanding questions. The redshift range 1.3 < z < 2 is a key epoch in this respect: elliptical galaxies start to become the dominant population in cluster cores, and star formation in spiral galaxies is being quenched. Until recently, however, this redshift range was essentially unreachable with available instrumentation, with clusters at these redshifts exceedingly challenging to identify from either ground-based optical/nearinfrared imaging or from X-ray surveys. Mid-infrared (MIR) imaging with the IRAC camera on board of the Spitzer Space Telescope has changed the landscape. High-redshift clusters are easily identified in the MIR due to a combination of the unique colors of distant galaxies and a negative k-correction in the 3-5 μm range which makes such galaxies bright. Even 90-sec observations with Spitzer/IRAC, a depth which essentially all extragalactic observations in the archive achieve, is sufficient to robustly detect overdensities of L* galaxies out to z~2. Here we request funding to embark on a ambitious scientific program, the “SACS: Spitzer Archival Cluster Survey”, a comprehensive search for the most distant galaxy clusters in all Spitzer/IRAC extragalactic pointings available in the archive. With the SACS we aim to discover ~2000 of 1.3 < z < 2.5 clusters, thus provide the ultimate catalog for high-redshift MIR selected clusters: a lasting legacy for Spitzer. The study we propose will increase by more than a factor of 10 the number of high-redshift clusters discovered by all previous surveys

  17. 10 CFR 71.74 - Accident conditions for air transport of plutonium.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... conditions in the order indicated to determine their cumulative effect. (1) Impact at a velocity of not less... velocity not less than the calculated terminal free-fall velocity, at mean sea level, at a right angle onto... velocity of the package is less than 129 m/sec (422 ft/sec), or if a velocity not less than either 129...

  18. 10 CFR 71.74 - Accident conditions for air transport of plutonium.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... conditions in the order indicated to determine their cumulative effect. (1) Impact at a velocity of not less... velocity not less than the calculated terminal free-fall velocity, at mean sea level, at a right angle onto... velocity of the package is less than 129 m/sec (422 ft/sec), or if a velocity not less than either 129...

  19. Hypothetical accident conditions, free drop and thermal tests: Specification 6M

    SciTech Connect

    Blankenship, R.W.

    1980-05-01

    The 30 gallon Specification 6M shipping container with rolled-top food pack cans as inner containers is evaluated under conditions required by 10 CFR 71.42. One kilogram of depleted uranium as UO/sub 2/ was packaged in each of the inner containers. After completion of a free drop test and a simulated thermal test, the maximum observed leakage of UO/sub 2/ for the following week was 3.2 ..mu..g. This leakage is well below the allowable leakage per week for most plutonium isotopic mixtures. Using the examples provided, any plutonium isotopic mixture can be easily compared with the allowable leakage per week. Test conditions and results are reported.

  20. Creation of Computational Benchmarks for LEU and MOX Fuel Assemblies Under Accident Conditions

    SciTech Connect

    Pavlovitchev, A M; Kalashnikov, A G; Kalugin, M A; Lazarenko, A P; Maiorov, L V; Sidorenko, V D

    1999-11-01

    The result of VVER-1000 computational benchmarks, calculations obtained with the use of various Russian codes (such as MCU-RFFI/A, TVS-M and WIMS-ABBN) are presented. List of benchmarks includes LEU and MOX cells with fresh and spent fuel under various conditions (for calculation of kinetic parameters, Doppler coefficient, reactivity effect of decreasing the water density). Calculations results are compared with each other and results of this comparison are discussed.

  1. SAC Availability for the IRIS Community

    SciTech Connect

    Goldstein, P; Snoke, A

    2005-04-06

    SAC (also known as SAC2000) is a signal processing and analysis code that has been developed by Lawrence Livermore National Laboratory (LLNL) over the past 20+ years for a variety of seismic and geophysical research projects. SAC has evolved into a general purpose interactive program designed for the study of sequential signals, especially time-series data. Emphasis has been placed on analysis tools used by research seismologists in the detailed study of seismic events. Analysis capabilities include general arithmetic operations, Fourier transforms, three spectral estimation techniques, IIR and FIR filtering, signal stacking, decimation, interpolation, correlation, and seismic phase picking. SAC also contains an extensive graphics capability. SAC is used extensively by the seismic community because: (1) it has a broad range of well-tested, efficient data analysis capabilities (examples include: data inspection, phase picking, signal correction, quality control, unary and binary data operations, travel-time analysis, spectral analysis including high-resolution spectral estimation, spectrograms and binary sonograms, and array and three-component analysis), (2) it is easy to use and reliable, (3) it has a macro programming language that allows users to develop innovative new analysis techniques, (4) it has interfaces to the Unix operating system, Matlab (www.mathworks.com), and the Generic Mapping Tools (GMT) software (Wessel and Smith, 1991, 1998 and gmt.soest.hawaii.edu) that make it very flexible, allowing researchers to solve many research problems innovatively with minimal programming effort, and (5) the suite of analysis capabilities are integrated so that innovative processing schemes are easily implemented. SAC is also widely used because of its user oriented development philosophy, which has led to consistent, easy to use capabilities that are backward compatible. A sample of some of SAC's capabilities is displayed in Figure 1.

  2. TRUMP-BD: A computer code for the analysis of nuclear fuel assemblies under severe accident conditions

    SciTech Connect

    Lombardo, N.J.; Marseille, T.J.; White, M.D.; Lowery, P.S.

    1990-06-01

    TRUMP-BD (Boil Down) is an extension of the TRUMP (Edwards 1972) computer program for the analysis of nuclear fuel assemblies under severe accident conditions. This extension allows prediction of the heat transfer rates, metal-water oxidation rates, fission product release rates, steam generation and consumption rates, and temperature distributions for nuclear fuel assemblies under core uncovery conditions. The heat transfer processes include conduction in solid structures, convection across fluid-solid boundaries, and radiation between interacting surfaces. Metal-water reaction kinetics are modeled with empirical relationships to predict the oxidation rates of steam-exposed Zircaloy and uranium metal. The metal-water oxidation models are parabolic in form with an Arrhenius temperature dependence. Uranium oxidation begins when fuel cladding failure occurs; Zircaloy oxidation occurs continuously at temperatures above 13000{degree}F when metal and steam are available. From the metal-water reactions, the hydrogen generation rate, total hydrogen release, and temporal and spatial distribution of oxide formations are computed. Consumption of steam from the oxidation reactions and the effect of hydrogen on the coolant properties is modeled for independent coolant flow channels. Fission product release from exposed uranium metal Zircaloy-clad fuel is modeled using empirical time and temperature relationships that consider the release to be subject to oxidation and volitization/diffusion ( bake-out'') release mechanisms. Release of the volatile species of iodine (I), tellurium (Te), cesium (Ce), ruthenium (Ru), strontium (Sr), zirconium (Zr), cerium (Cr), and barium (Ba) from uranium metal fuel may be modeled.

  3. Molecular Dynamic Simulation of Sodium in 7-Pin LMFBR Bundle Under Hypothetical Accident Conditions

    SciTech Connect

    Bottoni, Maurizio; Bottoni, Claudio; Scanu, John

    2006-07-01

    In the frame of safety analysis of liquid metal fast breeder reactors (LMFBRs) under hypothetical Unprotected Loss of Flow (ULOF) conditions two-phase flow of sodium is simulated in a 7-pin bundle, with hexagonal lattice. Molecular dynamics, with the application of the Direct Simulation Monte Carlo (DSMC) method, and a macroscopic model describing rewetting sequences due to the flow of a sodium liquid film along the pin surfaces, are applied to simulate the coolant in the bundle. The pin surfaces and the inner surface of the hexagonal canning are treated in the Monte Carlo simulation as diffusively reflecting surfaces. Collisions of sodium molecules are computed with the 'hard-sphere' model. With respect to previous work the following improvements of the computational code were made: i) The full bundle is simulated, thus allowing for asymmetries, like a skewed power distribution, to be accounted for; ii) A pin model calculates detailed temperature distributions in the pins, so that temperature boundary conditions are computed and not imposed; iii) Post processing visualisation of computed results was developed. An out of pile sodium boiling experiment run at the Nuclear Research Center of Karlsruhe, Germany, is simulated and conclusions are drawn about the applicability of the methodology in computer codes dedicated to breeder reactors safety analysis. (authors)

  4. FASTGRASS: A mechanistic model for the prediction of Xe, I, Cs, Te, Ba, and Sr release from nuclear fuel under normal and severe-accident conditions

    SciTech Connect

    Rest, J.; Zawadzki, S.A. )

    1992-09-01

    The primary physical/chemical models that form the basis of the FASTGRASS mechanistic computer model for calculating fission-product release from nuclear fuel are described. Calculated results are compared with test data and the major mechanisms affecting the transport of fission products during steady-state and accident conditions are identified.

  5. Experimental results from containment piping bellows subjected to severe accident conditions. Volume 1, Results from bellows tested in `like-new` conditions

    SciTech Connect

    Lambert, L.D.; Parks, M.B.

    1994-09-01

    Bellows are an integral part of the containment pressure boundary in nuclear power plants. They are used at piping penetrations to allow relative movement between piping and the containment wall, while minimizing the load imposed on the piping and wall. Piping bellows are primarily used in steel containments; however, they have received limited use in some concrete (reinforced and prestressed) containments. In a severe accident they may be subjected to pressure and temperature conditions that exceed the design values, along with a combination of axial and lateral deflections. A test program to determine the leak-tight capacity of containment penetration bellows is being conducted under the sponsorship of the US Nuclear Regulatory Commission at Sandia National Laboratories. Several different bellows geometries, representative of actual containment bellows, have been subjected to extreme deflections along with pressure and temperature loads. The bellows geometries and loading conditions are described along with the testing apparatus and procedures. A total of thirteen bellows have been tested, all in the `like-new` condition. (Additional tests are planned of bellows that have been subjected to corrosion.) The tests showed that bellows are capable of withstanding relatively large deformations, up to, or near, the point of full compression or elongation, before developing leakage. The test data is presented and discussed.

  6. Cloud conditions for low atmospheric electricity during disturbed period after the Fukushima nuclear accident

    NASA Astrophysics Data System (ADS)

    Yatagai, Akiyo; Yamauchi, Masatoshi; Ishihara, Masahito; Watanabe, Akira; Murata, Ken T.

    2016-04-01

    The vertical (downward) component of the atmospheric electric field, or potential gradient (PG) under cloud generally reflects the electric charge distribution in the cloud. The PG data at Kakioka, 150 km southwest of the Fukushima Dai-ichi Nuclear Power Plant (FNPP1) suggested that this relation can be modified when the radioactive dust was floating in the air, and the exact relation between the weather and this modification could lead to new insight in plasma physics in the wet atmosphere. Unfortunately the detailed weather data was not available above Kakioka (only the precipitation data was available). Therefore, estimation of the cloud condition during March 2011 was strongly needed. We have developed various meteorological information links (http://www.chikyu.ac.jp/akiyo/firis/) and original radar and precipitation data will be released from the page. Here we present various radar images that we have prepared for March 2011. We prepared three-dimensional radar reflectivity of the C-band radar of JMA in every 10 minutes over all Kanto Plain centered at Tokyo and Fukushima prefecture centered at Sendai. We have released images of each altitude (1km interval) for 15th - 16thand 21th March (http://sc-web.nict.go.jp/fukushima/). The vertical structure of the rainfall is almost the same at 4km with the surface and sporadic high precipitation is observed at 6 km height for 15-16th. While, generally precipitation pattern that is similar to the surface is observed at 5km height on 21th. On the other hand, an X-band radar centered at Fukushima university is also used to know more localized raindrop patterns at zenith angle of 4 degree. We prepared 10-minutes/120m mesh precipitation patterns for March 15th, 16th, 17th, 18th, 20th, 21th, 22th and 23th. Quantitative estimate is difficult from this X-band radar, but localized structure, especially for the rain-band along Nakadori (middle valley in Fukushima prefecture), that is considered to determine the highly

  7. SAC-B, Argentine scientific satellite

    NASA Technical Reports Server (NTRS)

    Gulich, J. M.; White, C.

    1994-01-01

    The project and the missions of the Argentine scientific satellite, SAC-B, are summarized. SAC-B is an international cooperative project between NASA and the Secretariat of State of Science and Technology of the Argentine Republic. The objective of SAC-B is to advance the study of solar physics and astrophysics through the examination of solar flares, gamma ray burst sources and the diffuse soft X-ray cosmic background. The scientific payload comprises an instrument to measure the temporal evolution of X-ray emissions from solar flares as well as nonsolar gamma ray bursts, a combined soft X-ray and gamma ray burst detector, a diffuse X-ray background detector, and an energetic neutral atoms detector.

  8. A Surprise in the Lacrimal Sac

    PubMed Central

    Yuksel, Nilay; Akcay, Emine; Kilicarslan, Aydan; Ozen, Umut; Ozturk, Faruk

    2016-01-01

    To present a case with recurrent dacryocystitis as an unusual complication of medial orbital wall fracture repair with cartilage tissue graft. A 20-year-old male had facial trauma and underwent surgery to reconstruct right medial orbital wall fracture. During follow–up, he presented with continuous epiphora, mucopurulent discharge from the right eye. A thorough history taking indicated that medial orbital fracture was reconstructed with postauricular cartilage. We planned a standard external dacryocystorhinostomy (DCR). During the creation of lacrimal sac flaps, hard tissue was noted in the lacrimal sac. This tissue was excised and sent for pathological examination. The pathological examination revealed cartilage tissue. There were no further ipsilateral symptoms or complications after DCR. In patients with lacrimal system injury related to orbital wall fracture, iatrogenic foreign bodies in the lacrimal sac should be considered in patients with recurrent dacryocystitis who had reconstructive surgery for facial and orbital trauma. PMID:27555715

  9. Probabilities of Ground Impact Conditions of the New Horizons Spacecraft and RTG for Near Launch Pad Accidents

    NASA Astrophysics Data System (ADS)

    McGrath, Brian E.; Frostbutter, Dave A.; Chang, Yale

    2007-01-01

    As part of the Pluto New Horizons mission's safety effort, assessment of accidental ground impacts of the spacecraft (SC) and its components, including the radioisotope thermoelectric generator (RTG), near the launch pad are of particular interest as they determine the severity of the mechanical insult to the hardware. Two configurations are studied: the SC with RTG joined to the third stage STAR™ 48B solid rocket motor [Launch Vehicle (LV) payload], and the RTG joined to the RTG mounting fixture but separated from the SC after an at-altitude destruct action. The objective of the analyses conducted is to determine the probabilities of impact orientation and average impact velocity of these configurations for a near launch pad accident These are of interest because of the possibility that the STAR 48B solid rocket motor could impact on top of the RTG, and because the RTG/RTG mounting fixture impact orientations probabilities and velocities directly affect the mechanical response of the internal GPHS modules. The probabilities of impact orientation and impact velocity of the LV payload as a function of mission elapsed time at thrust termination are determined using a six degree of freedom motion simulation computer program coupled with a Monte Carlo method. The motion simulation accounts for the LV payload aerodynamic properties, mass properties, and the initial flight conditions (αt, γ, V, q and r). Baseline conditions for position, direction, velocity and angular rates, are obtained from the mission timeline information for the Atlas V 551 launch vehicle. The results from this new and unique approach contributed information to safety assessments for the launch approval process. As the environments associated with the RTG/RTG mounting fixture impact orientations probabilities and velocities were less severe than earlier assumptions, this contributed to a reduction in the estimated risk for the Pluto mission.

  10. Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation

    PubMed Central

    Monje-Casas, Fernando

    2015-01-01

    Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact on chromosome segregation. This is most evident in Saccharomyces cerevisiae, since in this organism the lack of Aurora B is lethal and leads to severe aneuploidy problems, while the SAC is dispensable under normal growth conditions and mutants in this checkpoint do not show evident chromosome segregation defects. We demonstrate that the efficient repair of incorrect chromosome attachments by Aurora B during the initial stages of spindle assembly in budding yeast determines the lack of chromosome segregation defects in SAC mutants, and propose that the differential time window that Aurora B kinase requires to establish chromosome biorientation is the key factor that determines why some cells are more dependent on a functional SAC than others. PMID:26661752

  11. XPS of oxygen atoms on Ag(111) and Ag(110) surfaces: accurate study with SAC/SAC-CI combined with dipped adcluster model.

    PubMed

    Ishikawa, Atsushi; Nakatsuji, Hiroshi

    2013-08-01

    O1s core-electron binding energies (CEBE) of the atomic oxygens on different Ag surfaces were investigated by the symmetry adapted cluster-configuration interaction (SAC-CI) method combined with the dipped adcluster model, in which the electron exchange between bulk metal and adsorbate is taken into account properly. Electrophilic and nucleophilic oxygens (O(elec) and O(nuc)) that might be important for olefin epoxidation in a low-oxygen coverage condition were focused here. We consider the O1s CEBE as a key property to distinguish the surface oxygen states, and series of calculation was carried out by the Hartree-Fock, Density functional theory, and SAC/SAC-CI methods. The experimental information and our SAC/SAC-CI results indicate that O(elec) is the atomic oxygen adsorbed on the fcc site of Ag(111) and that O(nuc) is the one on the reconstructed added-row site of Ag(110) and that one- and two-electron transfers occur, respectively, to the O(elec) and O(nuc) adclusters from the silver surface.

  12. Malignant melanoma of the lacrimal sac.

    PubMed

    Yamade, S; Kitagawa, A

    1978-01-01

    A case of malignant melanoma of the lacrimal sac in a 41-year-old woman is reported, which is propably the 12th one in the world literature. Dacryocystectomy is advisable at a localized stage. The importance of early diagnosis is discussed. PMID:714368

  13. Comparing and Contrasting NAEYC and SACS Accreditation

    ERIC Educational Resources Information Center

    Isaacs, Mary Ruth

    2010-01-01

    The purpose of this paper is to describe, compare, and contrast an early childhood departmental accreditation process from the National Association for the Education of Young Children (NAEYC) and a college/university-wide accreditation process from the Southern Association of Colleges and Schools (SACS). The history of higher education…

  14. Accidents at work and living conditions among solid waste segregators in the open dump of Distrito Federal.

    PubMed

    Hoefel, Maria da Graça; Carneiro, Fernando Ferreira; Santos, Leonor Maria Pacheco; Gubert, Muriel Bauerman; Amate, Elisa Maria; dos Santos, Wallace

    2013-09-01

    The work of recycling solid waste segregators allows a precarious livelihood, but triggers a disease process that exacerbates their health and well-being. This study aimed to estimate the prevalence of occupational accidents at the open dump in the Federal District and its associated factors. Most segregators have had an accident at work (55.5%), perceived the danger of their working environment (95.0%) and claimed they did not receive personal protective equipment (51.7%). Among other findings, 55.8% ate foods found in the trash, 50.0% experienced food insecurity at home and 44.8% received Bolsa Família. There was a statistically significant relationship between work accidents and perception of dangerous work environment, household food insecurity and the presence of fatigue, stress or sadness (p < 0.05). On the other hand, the fellowship between the segregators was associated with a lower prevalence of accidents (p < 0.006). Women are the majority of the segregators (56.5%) and reported more accidents than men (p < 0.025). We conclude that the solid waste segregators constitute a vulnerable community, not only from the perspective of labor, but also from the social and environmental circumstances. To reverse this situation, effective implementation of the National Policy of Solid Wastes is imperative, in association with affirmative policies to grant economic emancipation for this population. PMID:24896289

  15. Accidents at work and living conditions among solid waste segregators in the open dump of Distrito Federal.

    PubMed

    Hoefel, Maria da Graça; Carneiro, Fernando Ferreira; Santos, Leonor Maria Pacheco; Gubert, Muriel Bauerman; Amate, Elisa Maria; dos Santos, Wallace

    2013-09-01

    The work of recycling solid waste segregators allows a precarious livelihood, but triggers a disease process that exacerbates their health and well-being. This study aimed to estimate the prevalence of occupational accidents at the open dump in the Federal District and its associated factors. Most segregators have had an accident at work (55.5%), perceived the danger of their working environment (95.0%) and claimed they did not receive personal protective equipment (51.7%). Among other findings, 55.8% ate foods found in the trash, 50.0% experienced food insecurity at home and 44.8% received Bolsa Família. There was a statistically significant relationship between work accidents and perception of dangerous work environment, household food insecurity and the presence of fatigue, stress or sadness (p < 0.05). On the other hand, the fellowship between the segregators was associated with a lower prevalence of accidents (p < 0.006). Women are the majority of the segregators (56.5%) and reported more accidents than men (p < 0.025). We conclude that the solid waste segregators constitute a vulnerable community, not only from the perspective of labor, but also from the social and environmental circumstances. To reverse this situation, effective implementation of the National Policy of Solid Wastes is imperative, in association with affirmative policies to grant economic emancipation for this population.

  16. 75. SAC control center underground structure middle floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    75. SAC control center underground structure middle floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  17. 72. SAC control center underground structure lower floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. SAC control center underground structure lower floor plan, drawing number 32-02-03, dated 1 February 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  18. 77. SAC control center administrative section basement floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    77. SAC control center administrative section basement floor plan, drawing number not listed, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  19. 78. SAC control center aboveground addition partial first floor plan, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. SAC control center aboveground addition partial first floor plan, drawing number AW30-02-09, dated 15 October, 1962 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  20. 76. SAC control center underground structure upper floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    76. SAC control center underground structure upper floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  1. 79. SAC control center administration section first floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    79. SAC control center administration section first floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  2. 80. SAC control center administration section third floor plan, drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. SAC control center administration section third floor plan, drawing number 32-02-03, dated 1 February, 1955 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  3. 68. Aerial view of SAC command post, building 500, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. Aerial view of SAC command post, building 500, looking northeast, spring, 1957 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  4. 63. Aerial view of SAC command post construction, looking west ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. Aerial view of SAC command post construction, looking west - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  5. 67. Aerial view of SAC command post, building 500, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    67. Aerial view of SAC command post, building 500, looking northeast, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  6. 62. Aerial view of SAC command post, building 500, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    62. Aerial view of SAC command post, building 500, looking east - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  7. 3. Threequarter view of building 500 looking southeast from SAC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Three-quarter view of building 500 looking southeast from SAC Boulevard - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  8. 13. SAC command center, weather center, underground structure, building 501, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. SAC command center, weather center, underground structure, building 501, undated - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Command Center, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  9. Surveillance Analysis Computer System (SACS) software requirements specification (SRS)

    SciTech Connect

    Glasscock, J.A.; Flanagan, M.J.

    1995-09-01

    This document is the primary document establishing requirements for the Surveillance Analysis Computer System (SACS) Database, an Impact Level 3Q system. The purpose is to provide the customer and the performing organization with the requirements for the SACS Project.

  10. Aneurysm sac shrinkage after endovascular treatment of the aorta: beyond sac pressure and endoleaks.

    PubMed

    Georgakarakos, Efstratios; Georgiadis, George S; Ioannou, Christos V; Kapoulas, Konstantinos C; Trellopoulos, George; Lazarides, Miltos

    2012-06-01

    The isolation of the aneurysm sac from systemic pressure and its consequent shrinkage are considered criteria of success after endovascular repair (EVAR). However, the process of shrinkage does not solely depend on the intrasac pressure, the predictive role of which remains ambiguous. This brief review summarizes the additional pathophysiological mechanisms that regulate the biomechanical properties of the aneurysm wall and may interfere with the process of aneurysm sac shrinkage. PMID:22402935

  11. FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness

    PubMed Central

    Li, Han; Lin, Kexin; Shahmirzadi, Danial

    2016-01-01

    This study aims to quantify the effects of geometry and stiffness of aneurysms on the pulse wave velocity (PWV) and propagation in fluid–solid interaction (FSI) simulations of arterial pulsatile flow. Spatiotemporal maps of both the wall displacement and fluid velocity were generated in order to obtain the pulse wave propagation through fluid and solid media, and to examine the interactions between the two waves. The results indicate that the presence of abdominal aortic aneurysm (AAA) sac and variations in the sac modulus affect the propagation of the pulse waves both qualitatively (eg, patterns of change of forward and reflective waves) and quantitatively (eg, decreasing of PWV within the sac and its increase beyond the sac as the sac stiffness increases). The sac region is particularly identified on the spatiotemporal maps with a region of disruption in the wave propagation with multiple short-traveling forward/reflected waves, which is caused by the change in boundary conditions within the saccular region. The change in sac stiffness, however, is more pronounced on the wall displacement spatiotemporal maps compared to those of fluid velocity. We conclude that the existence of the sac can be identified based on the solid and fluid pulse waves, while the sac properties can also be estimated. This study demonstrates the initial findings in numerical simulations of FSI dynamics during arterial pulsations that can be used as reference for experimental and in vivo studies. Future studies are needed to demonstrate the feasibility of the method in identifying very mild sacs, which cannot be detected from medical imaging, where the material property degradation exists under early disease initiation. PMID:27478394

  12. Direct Effects of Microalgae and Protists on Herring (Clupea harengus) Yolk Sac Larvae

    PubMed Central

    Illing, Björn; Moyano, Marta; Niemax, Jan; Peck, Myron A.

    2015-01-01

    This study investigated effects of microalgae (Rhodomonas baltica) and heterotrophic protists (Oxyrrhis marina) on the daily growth, activity, condition and feeding success of Atlantic herring (Clupea harengus) larvae from hatch, through the end of the endogenous (yolk sac) period. Yolk sac larvae were reared in the presence and absence of microplankton and, each day, groups of larvae were provided access to copepods. Larvae reared with microalgae and protists exhibited precocious (2 days earlier) and ≥ 60% increased feeding incidence on copepods compared to larvae reared in only seawater (SW). In the absence and presence of microalgae and protists, life span and growth trajectories of yolk sac larvae were similar and digestive enzyme activity (trypsin) and nutritional condition (RNA-DNA ratio) markedly declined in all larvae directly after yolk sac depletion. Thus, microplankton promoted early feeding but was not sufficient to alter life span and growth during the yolk sac phase. Given the importance of early feeding, field programs should place greater emphasis on the protozooplankton-ichthyoplankton link to better understand match-mismatch dynamics and bottom-up drivers of year class success in marine fish. PMID:26035592

  13. Direct Effects of Microalgae and Protists on Herring (Clupea harengus) Yolk Sac Larvae.

    PubMed

    Illing, Björn; Moyano, Marta; Niemax, Jan; Peck, Myron A

    2015-01-01

    This study investigated effects of microalgae (Rhodomonas baltica) and heterotrophic protists (Oxyrrhis marina) on the daily growth, activity, condition and feeding success of Atlantic herring (Clupea harengus) larvae from hatch, through the end of the endogenous (yolk sac) period. Yolk sac larvae were reared in the presence and absence of microplankton and, each day, groups of larvae were provided access to copepods. Larvae reared with microalgae and protists exhibited precocious (2 days earlier) and ≥ 60% increased feeding incidence on copepods compared to larvae reared in only seawater (SW). In the absence and presence of microalgae and protists, life span and growth trajectories of yolk sac larvae were similar and digestive enzyme activity (trypsin) and nutritional condition (RNA-DNA ratio) markedly declined in all larvae directly after yolk sac depletion. Thus, microplankton promoted early feeding but was not sufficient to alter life span and growth during the yolk sac phase. Given the importance of early feeding, field programs should place greater emphasis on the protozooplankton-ichthyoplankton link to better understand match-mismatch dynamics and bottom-up drivers of year class success in marine fish.

  14. Direct Effects of Microalgae and Protists on Herring (Clupea harengus) Yolk Sac Larvae.

    PubMed

    Illing, Björn; Moyano, Marta; Niemax, Jan; Peck, Myron A

    2015-01-01

    This study investigated effects of microalgae (Rhodomonas baltica) and heterotrophic protists (Oxyrrhis marina) on the daily growth, activity, condition and feeding success of Atlantic herring (Clupea harengus) larvae from hatch, through the end of the endogenous (yolk sac) period. Yolk sac larvae were reared in the presence and absence of microplankton and, each day, groups of larvae were provided access to copepods. Larvae reared with microalgae and protists exhibited precocious (2 days earlier) and ≥ 60% increased feeding incidence on copepods compared to larvae reared in only seawater (SW). In the absence and presence of microalgae and protists, life span and growth trajectories of yolk sac larvae were similar and digestive enzyme activity (trypsin) and nutritional condition (RNA-DNA ratio) markedly declined in all larvae directly after yolk sac depletion. Thus, microplankton promoted early feeding but was not sufficient to alter life span and growth during the yolk sac phase. Given the importance of early feeding, field programs should place greater emphasis on the protozooplankton-ichthyoplankton link to better understand match-mismatch dynamics and bottom-up drivers of year class success in marine fish. PMID:26035592

  15. What is inside the hernia sac?

    PubMed Central

    Virgínia, Ana Araújo; Santos, Cláudia; Contente, Helena; Branco, Cláudia

    2016-01-01

    Most ovarian inguinal hernias occur in children and are frequently associated with congenital genitalia defects. The authors present the case of a multiparous 89-year-old woman, without any genitalia defect, who was brought to the emergency department with an irreducible inguinal hernia. The patient was proposed for emergency surgery during which we encountered an ovary and a fallopian tube inside the hernial sac. An oophorosalpingectomy and a Lichtenstein procedure were carried out and the postoperative period was uneventful. This case shows that, even though it is rare, a hernial sac may contain almost any intra-abdominal organ, including those least frequent such as the appendix, an ovary or the fallopian tubes. PMID:27511751

  16. Aquarius/SAC-D Mission Overview

    NASA Technical Reports Server (NTRS)

    Sen, Amit; Kim, Yunjin; Caruso, Daniel; Lagerloef, Gary; Colomb, Raul; Yueh, Simon; LeVine, David

    2006-01-01

    Aquarius/SAC-D is a cooperative international mission developed between the National Aeronautics and Space Administration (NASA) of United States of America (USA) and the Comision Nacional de Actividades Espaciales (CONAE) of Argentina. The overall mission objective is to contribute to the understanding of the total Earth system and the consequences of the natural and man-made changes in the environment of the planet. Major themes are: ocean surface salinity, water cycle, climate, natural hazards and cryosphere.

  17. VICTORIA: A mechanistic model of radionuclide behavior in the reactor coolant system under severe accident conditions. Revision 1

    SciTech Connect

    Heams, T J; Williams, D A; Johns, N A; Mason, A; Bixler, N E; Grimley, A J; Wheatley, C J; Dickson, L W; Osborn-Lee, I; Domagala, P; Zawadzki, S; Rest, J; Alexander, C A; Lee, R Y

    1992-12-01

    The VICTORIA model of radionuclide behavior in the reactor coolant system (RCS) of a light water reactor during a severe accident is described. It has been developed by the USNRC to define the radionuclide phenomena and processes that must be considered in systems-level models used for integrated analyses of severe accident source terms. The VICTORIA code, based upon this model, predicts fission product release from the fuel, chemical reactions involving fission products, vapor and aerosol behavior, and fission product decay heating. Also included is a detailed description of how the model is implemented in VICTORIA, the numerical algorithms used, and the correlations and thermochemical data necessary for determining a solution. A description of the code structure, input and output, and a sample problem are provided.

  18. Pollen tubes introduce Raspberry bushy dwarf virus into embryo sacs during fertilization processes.

    PubMed

    Isogai, Masamichi; Yoshida, Tetu; Shimura, Takuya; Yoshikawa, Nobuyuki

    2015-10-01

    We developed a fertilization method in which pollen tubes entered into embryo sacs without any need to contact surrounding female sporophytic cells by using Torenia fournieri (Torenia) plants under the condition of hindering movement of the virus from a stigma, which is the first infection site leading to systemic infection. When RBDV-infected Torenia pollen grains were used for the developed fertilization method, the virus was transmitted to the seeds by pollen tubes germinating from them. On the other hand, no seeds were infected with the virus when Torenia plants were pollinated with healthy Torenia pollen grains in combination with RBDV-infected raspberry pollen grains, which caused the virus infection in the stigma by penetration of their pollen tubes arrested in its style. Our results indicate that vertical transmission of RBDV by pollen occurs in the transport of the virus into embryo sacs by pollen tubes reaching the embryo sacs.

  19. Pollen tubes introduce Raspberry bushy dwarf virus into embryo sacs during fertilization processes.

    PubMed

    Isogai, Masamichi; Yoshida, Tetu; Shimura, Takuya; Yoshikawa, Nobuyuki

    2015-10-01

    We developed a fertilization method in which pollen tubes entered into embryo sacs without any need to contact surrounding female sporophytic cells by using Torenia fournieri (Torenia) plants under the condition of hindering movement of the virus from a stigma, which is the first infection site leading to systemic infection. When RBDV-infected Torenia pollen grains were used for the developed fertilization method, the virus was transmitted to the seeds by pollen tubes germinating from them. On the other hand, no seeds were infected with the virus when Torenia plants were pollinated with healthy Torenia pollen grains in combination with RBDV-infected raspberry pollen grains, which caused the virus infection in the stigma by penetration of their pollen tubes arrested in its style. Our results indicate that vertical transmission of RBDV by pollen occurs in the transport of the virus into embryo sacs by pollen tubes reaching the embryo sacs. PMID:26176979

  20. New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects.

    PubMed

    Dong, Daoyin; Reece, E Albert; Lin, Xue; Wu, Yanqing; AriasVillela, Natalia; Yang, Peixin

    2016-02-01

    Maternal diabetes mellitus is a significant risk factor for structural birth defects, including congenital heart defects and neural tube defects. With the rising prevalence of type 2 diabetes mellitus and obesity in women of childbearing age, diabetes mellitus-induced birth defects have become an increasingly significant public health problem. Maternal diabetes mellitus in vivo and high glucose in vitro induce yolk sac injuries by damaging the morphologic condition of cells and altering the dynamics of organelles. The yolk sac vascular system is the first system to develop during embryogenesis; therefore, it is the most sensitive to hyperglycemia. The consequences of yolk sac injuries include impairment of nutrient transportation because of vasculopathy. Although the functional relationship between yolk sac vasculopathy and structural birth defects has not yet been established, a recent study reveals that the quality of yolk sac vasculature is related inversely to embryonic malformation rates. Studies in animal models have uncovered key molecular intermediates of diabetic yolk sac vasculopathy, which include hypoxia-inducible factor-1α, apoptosis signal-regulating kinase 1, and its inhibitor thioredoxin-1, c-Jun-N-terminal kinases, nitric oxide, and nitric oxide synthase. Yolk sac vasculopathy is also associated with abnormalities in arachidonic acid and myo-inositol. Dietary supplementation with fatty acids that restore lipid levels in the yolk sac lead to a reduction in diabetes mellitus-induced malformations. Although the role of the human yolk in embryogenesis is less extensive than in rodents, nevertheless, human embryonic vasculogenesis is affected negatively by maternal diabetes mellitus. Mechanistic studies have identified potential therapeutic targets for future intervention against yolk sac vasculopathy, birth defects, and other complications associated with diabetic pregnancies.

  1. Periocular dirofilariasis mimicking lacrimal sac mucocoele.

    PubMed

    Pauly, Marian; Biswas, Jyotirmay; Hussain, Rameez N; Anantharaman, Giridhar

    2013-10-01

    Dirofilariasis is a zoonotic infection caused by filarial nematodes belonging to the genus dirofilariae. Dirofilaria is commonly seen in dogs, cats and other carnivorous animals world wide. Mosquitoes of the genus Culex, Anopheles and Aedes are the vectors and the humans are either incidental hosts or dead-end hosts. It affects lungs, liver and other visceral organs. Ocular involvement is rarely been reported. We present a case of 51-year-old female from Kerala, the southern State of India presented with a mass mimicking lacrimal sac mucocoele whose biopsy is proved to be dirofilariasis.

  2. Primary Nasopharngeal Yolk Sac Tumor: A Case Report.

    PubMed

    Arumugam, Dhanalakshmi; Thandavarayan, Pavithra; Chidambaram, Lalitha; Boj, Sudha; Marudasalam, Sumathi

    2016-05-01

    Yolk sac tumour also known as primitive endodermal tumour is the most common malignant germ cell tumour (GCT) in the paediatric age group. Most common sites of involvement are ovaries and testes, but rarely can occur in the extragonadal sites. In the head and neck region, yolk sac tumours have been reported in the nasopharynx, sinonasal tract, orbit, ear and parotid gland. Nasopharynx is an uncommon site for yolk sac tumour and very few cases of nasopharngeal pure yolk sac tumour have been reported so far. Yolk sac tumours are highly malignant and have a poor prognosis. This is a case of pure GCT in a three-year-old female child who presented with a rapidly growing nasopharyngeal mass. Histopathological examination followed by immunohistochemistry and serum AFP study clinched the diagnosis of yolk sac tumour. The tumour responded well to chemotherapy as evidenced by decrease in serum AFP levels. PMID:27437234

  3. Specific lignin accumulation in granulated juice sacs of Citrus maxima.

    PubMed

    Wu, Jia-Ling; Pan, Teng-Fei; Guo, Zhi-Xiong; Pan, Dong-Ming

    2014-12-17

    Juice sac granulation occurring in pummelo fruits [Citrus maxima (Burm.) Merr.] is an undesirable trait, and the underlying mechanism remains unresolved. Previous studies have shown that lignin metabolism is closely associated with the process of juice sac granulation. Here, a method suitable for lignin isolation from pummelo tissues is established. Acetylated lignins from different pummelo tissues and cultivars were analyzed by HSQC NMR. The results showed that lignins in granulated juice sacs were characterized by an extremely high abundance of guaiacyl units (91.13-96.82%), in contrast to lignins from other tissues, including leaves, stems, and segment membranes. The abnormally accumulated lignins in granulated juice sacs were specific and mainly polymerized from coniferyl alcohol. No significant difference was found in lignin types among various cultivars. These findings indicated that the mechanism of juice sac granulation might be similar among various cultivars, although very different degrees of juice sac granulation can be observed.

  4. Whisker Formation on SAC305 Soldered Assemblies

    NASA Astrophysics Data System (ADS)

    Meschter, S.; Snugovsky, P.; Bagheri, Z.; Kosiba, E.; Romansky, M.; Kennedy, J.; Snugovsky, L.; Perovic, D.

    2014-11-01

    This article describes the results of a whisker formation study on SAC305 assemblies, evaluating the effects of lead-frame materials and cleanliness in different environments: low-stress simulated power cycling (50-85°C thermal cycling), thermal shock (-55°C to 85°C), and high temperature/high humidity (85°C/85% RH). Cleaned and contaminated small outline transistors, large leaded quad flat packs (QFP), plastic leaded chip carrier packages, and solder balls with and without rare earth elements (REE) were soldered to custom designed test boards with Sn3Ag0.5Cu (SAC305) solder. After assembly, all the boards were cleaned, and half of them were recontaminated (1.56 µg/cm2 Cl-). Whisker length, diameter, and density were measured. Detailed metallurgical analysis on components before assembly and on solder joints before and after testing was performed. It was found that whiskers grow from solder joint fillets, where the thickness is less than 25 µm, unless REE was present. The influence of lead-frame and solder ball material, microstructure, cleanliness, and environment on whisker characteristics is discussed. This article provides detailed metallurgical observations and select whisker length data obtained during this multiyear testing program.

  5. Progressive myoclonus epilepsy associated with SACS gene mutations.

    PubMed

    Nascimento, Fábio A; Canafoglia, Laura; Aljaafari, Danah; Muona, Mikko; Lehesjoki, Anna-Elina; Berkovic, Samuel F; Franceschetti, Silvana; Andrade, Danielle M

    2016-08-01

    Pathogenic variants in the SACS gene (OMIM #604490) cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). ARSACS is a neurodegenerative early-onset progressive disorder, originally described in French Canadians, but later observed elsewhere.(1) Whole-exome sequencing of a large group of patients with unclassified progressive myoclonus epilepsies (PMEs) identified 2 patients bearing SACS gene mutations.(2) We detail the PME clinical features associated with SACS mutations and suggest the inclusion of the SACS gene in diagnostic screening of PMEs. PMID:27433545

  6. Regulation of the sacPA operon of Bacillus subtilis: identification of phosphotransferase system components involved in SacT activity.

    PubMed

    Arnaud, M; Vary, P; Zagorec, M; Klier, A; Debarbouille, M; Postma, P; Rapoport, G

    1992-05-01

    The sacT gene which controls the sacPA operon of Bacillus subtilis encodes a polypeptide homologous to the B. subtilis SacY and the Escherichia coli BglG antiterminators. Expression of the sacT gene is shown to be constitutive. The DNA sequence upstream from sacP contains a palindromic sequence which functions as a transcriptional terminator. We have previously proposed that SacT acts as a transcriptional antiterminator, allowing transcription of the sacPA operon. In strains containing mutations inactivating ptsH or ptsI, the expression of sacPA and sacB is constitutive. In this work, we show that this constitutivity is due to a fully active SacY antiterminator. In the wild-type sacT+ strain or in the sacT30 mutant, SacT requires both enzyme I and HPr of the phosphotransferase system (PTS) for antitermination. It appears that the PTS exerts different effects on the sacB gene and the sacPA operon. The general proteins of the PTS are not required for the activity of SacY while they are necessary for SacT activity. PMID:1577686

  7. Radiotherapy Accidents

    NASA Astrophysics Data System (ADS)

    Mckenzie, Alan

    A major benefit of a Quality Assurance system in a radiotherapy centre is that it reduces the likelihood of an accident. For over 20 years I have been the interface in the UK between the Institute of Physics and Engineering in Medicine and the media — newspapers, radio and TV — and so I have learned about radiotherapy accidents from personal experience. In some cases, these accidents did not become public and so the hospital cannot be identified. Nevertheless, lessons are still being learned.

  8. On the robustness of SAC silencing in closed mitosis

    NASA Astrophysics Data System (ADS)

    Ruth, Donovan; Liu, Jian

    Mitosis equally partitions sister chromatids to two daughter cells. This is achieved by properly attaching these chromatids via their kinetochores to microtubules that emanate from the spindle poles. Once the last kinetochore is properly attached, the spindle microtubules pull the sister chromatids apart. Due to the dynamic nature of microtubules, however, kinetochore-microtubule attachment often goes wrong. When this erroneous attachment occurs, it locally activates an ensemble of proteins, called the spindle assembly checkpoint proteins (SAC), which halts the mitotic progression until all the kinetochores are properly attached by spindle microtubules. The timing of SAC silencing thus determines the fidelity of chromosome segregation. We previously established a spatiotemporal model that addresses the robustness of SAC silencing in open mitosis for the first time. Here, we focus on closed mitosis by examining yeast mitosis as a model system. Though much experimental work has been done to study the SAC in cells undergoing closed mitosis, the processes responsible are not well understood. We leverage and extend our previous model to study SAC silencing mechanism in closed mitosis. We show that a robust signal of the SAC protein accumulation at the spindle pole body can be achieved. This signal is a nonlinear increasing function of number of kinetochore-microtubule attachments, and can thus serve as a robust trigger to time the SAC silencing. Together, our mechanism provides a unified framework across species that ensures robust SAC silencing and fidelity of chromosome segregation in mitosis. Intramural research program in NHLBI at NIH.

  9. Fibrous dysplasia-like tumor of the lacrimal sac.

    PubMed

    Scott, Garrett R; Frueh, Bartley R; Flint, Andrew; Elner, Victor M

    2008-01-01

    A 75-year-old woman developed epiphora and a slowly enlarging right medial canthal mass for 1 year. CT revealed a mass with ground-glass radiodensity and hazy borders in the lacrimal sac. At external dacryocystorhinostomy, a tan, gritty, spherical mass was easily removed from the sac lumen. Histopathologic characteristics were typical of fibrous dysplasia. The postoperative course was uneventful.

  10. Laparoscopic management of hydatid cyst in the lesser sac

    PubMed Central

    Sahoo, Manash Ranjan; Kumar, Saurabh; Panda, Srikanta; Shameel, P. Ahammed

    2016-01-01

    Hydatid cyst is a disease caused by Echinococcus granulosus. Various anatomical location of hydatid cyst has been described in literature. Liver is the most common site of hydatid cyst and lungs are the second most common site. Hydatid cyst of lesser sac is a rare entity. Here we present a rare case report of laparoscopic management of hydatid cyst in lesser sac. PMID:27073313

  11. Aircraft accident survivors as witnesses.

    PubMed

    Dodge, R E

    1983-02-01

    This is a study of the reliability of aircrash survivors as witnesses. Some of their statements are compared to known facts at the time of the crash, including the time of the accident and the weather conditions. Other facts are compared between the survivors, such as the mood of the passengers immediately post-crash. The KLM-Pan Am accident in the Canary Islands is used as the study accident. A suggestion for future use of survivors' statements is tendered.

  12. Differential air sac pressures in diving tufted ducks Aythya fuligula.

    PubMed

    Boggs, D F; Butler, P J; Wallace, S E

    1998-09-01

    The air in the respiratory system of diving birds contains a large proportion of the body oxygen stores, but it must be in the lungs for gas exchange with blood to occur. To test the hypothesis that locomotion induces mixing of air sac air with lung air during dives, we measured differential pressures between the interclavicular and posterior thoracic air sacs in five diving tufted ducks Aythya fuligula. The peak differential pressure between posterior thoracic and interclavicular air sacs, 0.49+/-0.13 kPa (mean +/- s.d.), varied substantially during underwater paddling as indicated by gastrocnemius muscle activity. These data support the hypothesis that locomotion, perhaps through associated abdominal muscle activity, intermittently compresses the posterior air sacs more than the anterior ones. The result is differential pressure fluctuations that might induce the movement of air between air sacs and through the lungs during dives. PMID:9716518

  13. Ground water in the Cul-de-Sac Plain, Haiti

    USGS Publications Warehouse

    Taylor, George C.; Lemoine, Rémy C.

    1949-01-01

    The Cul-de-Sac Plain is perhaps the most important agricultural area in Haiti because of its nearness and accessibility to Port-au-Prince, the nation's capital, metropolis, and principal seaport. Most of the agricultural produce consumed in Port-au-Prince as well as a considerable part of that exported from Haiti is grown in the plain. Because of variable and poorly distributed rainfall, high temperature, and high evaporation, semiarid climatic conditions prevail in the plain. Irrigation is, therefore, necessary for successful farming. There are no regulatory or storage facilities on the streams that enter the plain, but the mean and low-water stream flow and the discharge of springs are almost entirely appropriated for irrigation. Ground water has been utilized for irrigation to an increasing extent by the Haitian American Sugar Company, which has put down about 100 wells in the plain since 1919. Outside the existing irrigated areas of the plain are large tracts of potentially irrigable land that are uncultivated and agriculturally unproductive for lack of water. The object of the present study was to determine the possibilities of bringing these lands into cultivation by irrigation from wells. This study was part of a larger program of the Food Supply Division, Institute of Inter-American Affairs, to increase the production of food in Haiti. From September through November 1948 the senior author, a member of the U. S. Geological Survey, spent three months in the field in an investigation of the geology and ground-water resources of the Cul-de-Sac Plain. He was ably assisted by Mr. Rémy C. Lemoine, Haitian engineer-geologist, employed by the Food Supply Division. The field work included principally the geologic mapping of' the plain and the adjacent mountain borders, a ground-water inventory of existing wells and springs, and a general evaluation of significant geologic and hydrologic features.

  14. Ground water in the Cul-de-Sac Plain, Haiti

    USGS Publications Warehouse

    Taylor, George C.; Lemoine, Rémy C.

    1949-01-01

    The Cul-de-Sac Plain is perhaps the most important agricultural area in Haiti because of its nearness and accessibility to Port-au-Prince, the nation's capital, metropolis, and principal seaport. Most of the agricultural produce consumed in Port-au-Prince as well as a considerable part of that exported from Haiti is grown in the plain.Because of variable and poorly distributed rainfall, high temperature, and high evaporation, semiarid climatic conditions prevail in the plain. Irrigation is, therefore, necessary for successful farming. There are no regulatory or storage facilities on the streams that enter the plain, but the mean and low-water stream flow and the discharge of springs are almost entirely appropriated for irrigation. Ground water has been utilized for irrigation to an increasing extent by the Haitian American Sugar Company, which has put down about 100 wells in the plain since 1919.Outside the existing irrigated areas of the plain are large tracts of potentially irrigable land that are uncultivated and agriculturally unproductive for lack of water. The object of the present study was to determine the possibilities of bringing these lands into cultivation by irrigation from wells. This study was part of a larger program of the Food Supply Division, Institute of Inter-American Affairs, to increase the production of food in Haiti.From September through November 1948 the senior author, a member of the U. S. Geological Survey, spent three months in the field in an investigation of the geology and ground-water resources of the Cul-de-Sac Plain. He was ably assisted by Mr. Rémy C. Lemoine, Haitian engineer-geologist, employed by the Food Supply Division. The field work included principally the geologic mapping of' the plain and the adjacent mountain borders, a ground-water inventory of existing wells and springs, and a general evaluation of significant geologic and hydrologic features.

  15. Accident management information needs

    SciTech Connect

    Hanson, D.J.; Ward, L.W.; Nelson, W.R.; Meyer, O.R. )

    1990-04-01

    In support of the US Nuclear Regulatory Commission (NRC) Accident Management Research Program, a methodology has been developed for identifying the plant information needs necessary for personnel involved in the management of an accident to diagnose that an accident is in progress, select and implement strategies to prevent or mitigate the accident, and monitor the effectiveness of these strategies. This report describes the methodology and presents an application of this methodology to a Pressurized Water Reactor (PWR) with a large dry containment. A risk-important severe accident sequence for a PWR is used to examine the capability of the existing measurements to supply the necessary information. The method includes an assessment of the effects of the sequence on the measurement availability including the effects of environmental conditions. The information needs and capabilities identified using this approach are also intended to form the basis for more comprehensive information needs assessment performed during the analyses and development of specific strategies for use in accident management prevention and mitigation. 3 refs., 16 figs., 7 tabs.

  16. Primitive fitting based on the efficient multiBaySAC algorithm.

    PubMed

    Kang, Zhizhong; Li, Zhen

    2015-01-01

    Although RANSAC is proven to be robust, the original RANSAC algorithm selects hypothesis sets at random, generating numerous iterations and high computational costs because many hypothesis sets are contaminated with outliers. This paper presents a conditional sampling method, multiBaySAC (Bayes SAmple Consensus), that fuses the BaySAC algorithm with candidate model parameters statistical testing for unorganized 3D point clouds to fit multiple primitives. This paper first presents a statistical testing algorithm for a candidate model parameter histogram to detect potential primitives. As the detected initial primitives were optimized using a parallel strategy rather than a sequential one, every data point in the multiBaySAC algorithm was assigned to multiple prior inlier probabilities for initial multiple primitives. Each prior inlier probability determined the probability that a point belongs to the corresponding primitive. We then implemented in parallel a conditional sampling method: BaySAC. With each iteration of the hypothesis testing process, hypothesis sets with the highest inlier probabilities were selected and verified for the existence of multiple primitives, revealing the fitting for multiple primitives. Moreover, the updated version of the initial probability was implemented based on a memorable form of Bayes' Theorem, which describes the relationship between prior and posterior probabilities of a data point by determining whether the hypothesis set to which a data point belongs is correct. The proposed approach was tested using real and synthetic point clouds. The results show that the proposed multiBaySAC algorithm can achieve a high computational efficiency (averaging 34% higher than the efficiency of the sequential RANSAC method) and fitting accuracy (exhibiting good performance in the intersection of two primitives), whereas the sequential RANSAC framework clearly suffers from over- and under-segmentation problems. Future work will aim at further

  17. Primitive Fitting Based on the Efficient multiBaySAC Algorithm

    PubMed Central

    Kang, Zhizhong; Li, Zhen

    2015-01-01

    Although RANSAC is proven to be robust, the original RANSAC algorithm selects hypothesis sets at random, generating numerous iterations and high computational costs because many hypothesis sets are contaminated with outliers. This paper presents a conditional sampling method, multiBaySAC (Bayes SAmple Consensus), that fuses the BaySAC algorithm with candidate model parameters statistical testing for unorganized 3D point clouds to fit multiple primitives. This paper first presents a statistical testing algorithm for a candidate model parameter histogram to detect potential primitives. As the detected initial primitives were optimized using a parallel strategy rather than a sequential one, every data point in the multiBaySAC algorithm was assigned to multiple prior inlier probabilities for initial multiple primitives. Each prior inlier probability determined the probability that a point belongs to the corresponding primitive. We then implemented in parallel a conditional sampling method: BaySAC. With each iteration of the hypothesis testing process, hypothesis sets with the highest inlier probabilities were selected and verified for the existence of multiple primitives, revealing the fitting for multiple primitives. Moreover, the updated version of the initial probability was implemented based on a memorable form of Bayes’ Theorem, which describes the relationship between prior and posterior probabilities of a data point by determining whether the hypothesis set to which a data point belongs is correct. The proposed approach was tested using real and synthetic point clouds. The results show that the proposed multiBaySAC algorithm can achieve a high computational efficiency (averaging 34% higher than the efficiency of the sequential RANSAC method) and fitting accuracy (exhibiting good performance in the intersection of two primitives), whereas the sequential RANSAC framework clearly suffers from over- and under-segmentation problems. Future work will aim at further

  18. Operational conditions of storages for products of decontamination of the territories of Belarus after the accident at Chernobyl NPP and evaluation of their radioecological state

    SciTech Connect

    Skurat, V.V.; Shiryaeva, N.M.; Gvozdev, A.A.; Serebryanyi, G.Z.; Myshkina, N.K.; Starobinets, S.E.; Kotovich, V.V.

    1995-12-31

    As a result of carrying out the measures on decontamination of the territory of Belarus after the Chernobyl accident, the storages for radioactive products of decontamination have been arranged in the Republic. Up to now, 69 storage sites for radioactive products of decontamination have been examined and registered. Six of them, the most typical, with the highest activity, are under constant control with the help of the network of the hydrogeological observation holes. The analysis of the field conditions of the storage sites at the territory of Belarus has shown that there is the violation of requirements for safe storage practically for all storages. The evaluation of protection of the ground water against radioactive contamination has shown, that in 10--100 years, the contamination of the ground water with caesium-137 is possible in concentrations lower than the Republican permissible levels and with strontium in concentrations significantly exceeding the specified values.

  19. Licensing topical report: the measurement and modelling of time-dependent fission product release from failed HTGR fuel particles under accident conditions

    SciTech Connect

    Myers, B.F.; Morrissey, R.E.

    1980-04-01

    The release of fission products from failed fuel particles was measured under simulated accident (core heatup) conditions. A generic model and specific model parameters that describe delayed fission product release from the kernels of failed HTGR fuel particles were developed from the experimental results. The release of fission products was measured from laser-failed BISO ThO/sub 2/ and highly enriched (HEU) TRISO UC/sub 2/ particles that had been irradiated to a range of kernel burnups. The burnups were 0.25, 1.4, and 15.7% FIMA for ThO/sub 2/ particles and 23.5 and 74% FIMA for UC/sub 2/ particles. The fission products measured were nuclides of xenon, iodine, krypton, tellurium, and cesium.

  20. Estimation of thermal loads on the VVER vessel under conditions of inversion of the stratified molten pool in a severe accident

    NASA Astrophysics Data System (ADS)

    Loktionov, V. D.; Mukhtarov, E. S.

    2016-09-01

    Analysis of the thermal state of molten pools that can be formed on the vessel bottom of the VVER-600 medium-power reactor during a severe anticipated accident with melting of the core is represented. Two types of the molten pool of core materials, with the two-layer and inverse three-layer stratification, are considered. Thermal loads acting on the reactor vessel from the melt are estimated depending on its formation time. Features of the thermal state of the melt in the case of its inverse stratification are analyzed. It is shown that thermal loads on the reactor vessel exceed the critical heat flux (CHF) when forming the two-layer stratified molten pool 10 and 24 h after its shutdown, and the thermal load is close to the corresponding CHF or somewhat exceeds it in 72 h. In the case of the formation of the inverse structure of the melt, one can observe a decrease by more than 2.5 times (in comparison with the two-layer stratified structure) in the thermal load on the reactor vessel in the region of its contact with the upper layer of the steel melt. Analysis of results showed that maximum densities of heat flux to the reactor vessel from the bottom metallic layer with the melt inversion did not exceed corresponding CHFs 24 and 72 h after the reactor shutdown. Because the thermal load on the reactor vessel can be localized in the region of its bottom, where the CHF is relatively small, during the inverse stratification of the melt, there is a need to carry out further in-depth experimental and analytical investigations of conditions for formation of the stratified molten pool and to obtain corrected experimental CHFs for conditions and outlines of cooling the external surface of the VVER-600 vessel in a severe accident.

  1. Factors affecting vertical distribution of Fukushima accident-derived radiocesium in soil under different land-use conditions.

    PubMed

    Koarashi, Jun; Atarashi-Andoh, Mariko; Matsunaga, Takeshi; Sato, Tsutomu; Nagao, Seiya; Nagai, Haruyasu

    2012-08-01

    The Fukushima Dai-ichi nuclear power plant accident in Japan, triggered by a big earthquake and the resulting tsunami on 11 March 2011, caused a substantial release of radiocesium ((137)Cs and (134)Cs) and a subsequent contamination of soils in a range of terrestrial ecosystems. Identifying factors and processes affecting radiocesium retention in these soils is essential to predict how the deposited radiocesium will migrate through the soil profile and to other biological components. We investigated vertical distributions of radiocesium and physicochemical properties in soils (to 20 cm depth) at 15 locations under different land-use types (croplands, grasslands, and forests) within a 2 km × 2 km mesh area in Fukushima city. The total (137)Cs inventory deposited onto and into soil was similar (58.4±9.6 kBq m(-2)) between the three different land-use types. However, aboveground litter layer at the forest sites and herbaceous vegetation at the non-forested sites contributed differently to the total (137)Cs inventory. At the forest sites, 50-91% of the total inventory was observed in the litter layer. The aboveground vegetation contribution was in contrast smaller (<35%) at the other sites. Another remarkable difference was found in vertical distribution of (137)Cs in mineral soil layers; (137)Cs penetrated deeper in the forest soil profiles than in the non-forested soil profiles. We quantified (137)Cs retention at surface soil layers, and showed that higher (137)Cs retention can be explained in part by larger amounts of silt- and clay-sized particles in the layers. More importantly, the (137)Cs retention highly and negatively correlated with soil organic carbon content divided by clay content across all land-use types. The results suggest that organic matter inhibits strong adsorption of (137)Cs on clay minerals in surface soil layers, and as a result affects the vertical distribution and thus the mobility of (137)Cs in soil, particularly in the forest ecosystems.

  2. Bilateral congenital lacrimal sac mucoceles with nasal extension and drainage.

    PubMed

    Divine, R D; Anderson, R L; Bumsted, R M

    1983-02-01

    A newborn infant with bilateral mucoceles of the lacrimal sacs also had submucosal masses along the floor of the nose beneath the inferior turbinates communicating with the mucoceles. Drainage of the mucoceles was performed by needle aspiration and wide marsupialization of the nasal masses into the nose under direct visualization. To our knowledge, this is the first time that intranasal extension of mucoceles has been reported, and the first time that lacrimal sac mucoceles have been successfully treated via direct nasal drainage. We advocate careful nasal evaluation in cases of congenital lacrimal sac mucoceles to determine whether intranasal extension is common and whether intranasal drainage can be curative.

  3. 79. Sac digital network (Sacdin), summary fault indicator at top, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    79. Sac digital network (Sacdin), summary fault indicator at top, south side - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

  4. Automatic segmentation and classification of gestational sac based on mean sac diameter using medical ultrasound image

    NASA Astrophysics Data System (ADS)

    Khazendar, Shan; Farren, Jessica; Al-Assam, Hisham; Sayasneh, Ahmed; Du, Hongbo; Bourne, Tom; Jassim, Sabah A.

    2014-05-01

    Ultrasound is an effective multipurpose imaging modality that has been widely used for monitoring and diagnosing early pregnancy events. Technology developments coupled with wide public acceptance has made ultrasound an ideal tool for better understanding and diagnosing of early pregnancy. The first measurable signs of an early pregnancy are the geometric characteristics of the Gestational Sac (GS). Currently, the size of the GS is manually estimated from ultrasound images. The manual measurement involves multiple subjective decisions, in which dimensions are taken in three planes to establish what is known as Mean Sac Diameter (MSD). The manual measurement results in inter- and intra-observer variations, which may lead to difficulties in diagnosis. This paper proposes a fully automated diagnosis solution to accurately identify miscarriage cases in the first trimester of pregnancy based on automatic quantification of the MSD. Our study shows a strong positive correlation between the manual and the automatic MSD estimations. Our experimental results based on a dataset of 68 ultrasound images illustrate the effectiveness of the proposed scheme in identifying early miscarriage cases with classification accuracies comparable with those of domain experts using K nearest neighbor classifier on automatically estimated MSDs.

  5. Thermal state of the safety system, reactor, side reflector and shielding of the {open_quote}{open_quote}TOPAZ-2{close_quote}{close_quote} system under conditions of fire caused by a launcher accident at the launch pad

    SciTech Connect

    Grinberg, E.I.; Doschatov, V.V.; Nikolaev, V.S.; Sokolov, N.S.; Usov, V.A.

    1996-03-01

    The paper presents some results of calculational analyses performed to determine thermal state of the TOPAZ II safety system structure, radiation shielding, reactor without the side reflector, rods and inserts of the side reflector under conditions of fire at the launch pad when an accident occurs to a launch vehicle. {copyright} {ital 1996 American Institute of Physics.}

  6. Intraoperative Sac Pressure Measurement During Endovascular Abdominal Aortic Aneurysm Repair

    SciTech Connect

    Ishibashi, Hiroyuki; Ishiguchi, Tsuneo; Ohta, Takashi; Sugimoto, Ikuo; Iwata, Hirohide; Yamada, Tetsuya; Tadakoshi, Masao; Hida, Noriyuki; Orimoto, Yuki; Kamei, Seiji

    2010-10-15

    PurposeIntraoperative sac pressure was measured during endovascular abdominal aortic aneurysm repair (EVAR) to evaluate the clinical significance of sac pressure measurement.MethodsA microcatheter was placed in an aneurysm sac from the contralateral femoral artery, and sac pressure was measured during EVAR procedures in 47 patients. Aortic blood pressure was measured as a control by a catheter from the left brachial artery.ResultsThe systolic sac pressure index (SPI) was 0.87 {+-} 0.10 after main-body deployment, 0.63 {+-} 0.12 after leg deployment (P < 0.01), and 0.56 {+-} 0.12 after completion of the procedure (P < 0.01). Pulse pressure was 55 {+-} 21 mmHg, 23 {+-} 15 mmHg (P < 0.01), and 16 {+-} 12 mmHg (P < 0.01), respectively. SPI showed no significant differences between the Zenith and Excluder stent grafts (0.56 {+-} 0.13 vs. 0.54 {+-} 0.10, NS). Type I endoleak was found in seven patients (15%), and the SPI decreased from 0.62 {+-} 0.10 to 0.55 {+-} 0.10 (P = 0.10) after fixing procedures. Type II endoleak was found in 12 patients (26%) by completion angiography. The SPI showed no difference between type II endoleak positive and negative (0.58 {+-} 0.12 vs. 0.55 {+-} 0.12, NS). There were no significant differences between the final SPI of abdominal aortic aneurysms in which the diameter decreased in the follow-up and that of abdominal aortic aneurysms in which the diameter did not change (0.53 {+-} 0.12 vs. 0.57 {+-} 0.12, NS).ConclusionsSac pressure measurement was useful for instant hemodynamic evaluation of the EVAR procedure, especially in type I endoleaks. However, on the basis of this small study, the SPI cannot be used to reliably predict sac growth or regression.

  7. Percutaneous Treatment of an Infected Aneurysmal Sac Secondary to Aortoesophageal Fistula with a History of Stent-Graft Treatment for Thoracic Aortic Aneurysm

    SciTech Connect

    Numan, Furuzan Gulsen, Fatih; Cantasdemir, Murat; Solak, Serdar; Arbatli, Harun

    2012-06-15

    A 68-year-old man who was subjected to stent-grafting of a descending thoracic aortic aneurysm (TAA) 4 months previously was admitted to our hospital with constitutional symptoms, including high fever, sweating, nausea, vomiting, weight loss, and backache. An infected aneurysmal sac was suspected based on computed tomography (CT) findings, and an aortoesophageal fistula (AEF) was identified during esophagoscopy. CT-guided aspiration was performed using a 20-G Chiba needle, confirming the presence of infection. For treatment of the infected aneurysmal sac, CT-guided percutaneous catheter drainage in a prone position was performed under general anesthesia with left endobronchial intubation. Drainage catheter insertion was successfully performed using the Seldinger technique, which is not a standard treatment of an infected aneurysmal sac. Improvement in the patient's clinical condition was observed at follow-ups, and CT showed total regression of the collection in the aneurysmal sac.

  8. The sac Mutants of Chlamydomonas reinhardtii Reveal Transcriptional and Posttranscriptional Control of Cysteine Biosynthesis1

    PubMed Central

    Ravina, Cristina G.; Chang, Chwenn-In; Tsakraklides, George P.; McDermott, Jeffery P.; Vega, Jose M.; Leustek, Thomas; Gotor, Cecilia; Davies, John P.

    2002-01-01

    Algae and vascular plants are cysteine (Cys) prototrophs. They are able to import, reduce, and assimilate sulfate into Cys, methionine, and other organic sulfur-containing compounds. Characterization of genes encoding the enzymes required for Cys biosynthesis from the unicellular green alga Chlamydomonas reinhardtii reveals that transcriptional and posttranscriptional mechanisms regulate the pathway. The derived amino acid sequences of the C. reinhardtii genes encoding 5′-adenylylsulfate (APS) reductase and serine (Ser) acetyltransferase are orthologous to sequences from vascular plants. The Cys biosynthetic pathway of C. reinhardtii is regulated by sulfate availability. The steady-state level of transcripts and activity of ATP sulfurylase, APS reductase, Ser acetyltransferase, and O-acetyl-Ser (thiol) lyase increase when cells are deprived of sulfate. The sac1 mutation, which impairs C. reinhardtii ability to acclimate to sulfur-deficient conditions, prevents the increase in accumulation of the transcripts encoding these enzymes and also prevents the increase in activity of all the enzymes except APS reductase. The sac2 mutation, which does not affect accumulation of APS reductase transcripts, blocks the increase in APS reductase activity. These results suggest that APS reductase activity is regulated posttranscriptionally in a SAC2-dependent process. PMID:12481091

  9. Aquarius and the Aquarius/SAC-D Mission

    NASA Technical Reports Server (NTRS)

    LeVine, D. M.; Lagerloef, G. S. E.; Torrusio, S.

    2010-01-01

    Aquarius is a combination L-band radiometer and scatterometer designed to map the salinity field at the ocean surface from space. It will be flown on the Aquarius/SAC-D mission, a partnership between the USA space agency (NASA) and Argentine space agency (CONAE). The mission is composed of two parts: (a) The Aquarius instrument being developed as part of NASA.s Earth System Science Pathfinder (ESSP) program; and (b) SAC-D the fourth spacecraft service platform in the CONAE Satellite de Aplicaciones Cientificas (SAC) program. The primary focus of the mission is to monitor the seasonal and interannual variations of the salinity field in the open ocean. The mission also meets the needs of the Argentine space program for monitoring the environment and for hazard detection and includes several instruments related to these goals.

  10. [Spanish adaptation of Hobfoll's Strategic Approach to Coping Scale (SACS)].

    PubMed

    Pedrero Pérez, Eduardo J; Santed Germán, Miguel A; Pérez García, Ana M

    2012-01-01

    The present research adapted the Strategic Approach to Coping Scale (SACS), developed by Hobfoll and colleagues, to the Spanish population. SACS is an instrument derived from Hobfoll's Conservation of Resources Theory, which emphasises the contribution of social factors to coping processes. This instrument assesses coping strategies in 9-subscales, organised in three dimensions: orientation to the problem (active/passive), use of social resources (prosocial/antisocial), and orientation to others involved (direct/indirect). The Spanish version, administered to a non-clinical sample (N= 767), found 7-subscales structured in prosocial/antisocial, active/passive and reflexive/intuitive dimensions, with adequate reliability and construct validity. To conclude, the Spanish SACS is a potentially useful and reliable instrument for research and clinical purposes, mainly in areas in which social components need to be explicitly considered.

  11. Radiation accidents

    SciTech Connect

    Saenger, E.L.

    1986-09-01

    It is essential that emergency physicians understand ways to manage patients contaminated by radioactive materials and/or exposed to external radiation sources. Contamination accidents require careful surveys to identify the metabolic pathway of the radionuclides to guide prognosis and treatment. The level of treatment required will depend on careful surveys and meticulous decontamination. There is no specific therapy for the acute radiation syndrome. Prophylactic antibodies are desirable. For severely exposed patients treatment is similar to the supportive care given to patients undergoing organ transplantation. For high-dose extremity injury, no methods have been developed to reverse the fibrosing endarteritis that eventually leads to tissue death so frequently found with this type of injury. Although the Three Mile Island episode of March 1979 created tremendous public concern, there were no radiation injuries. The contamination outside the reactor building and the release of radioiodine were negligible. The accidental fuel element meltdown at Chernobyl, USSR, resulted in many cases of acute radiation syndrome. More than 100,000 people were exposed to high levels of radioactive fallout. The general principles outlined here are applicable to accidents of that degree of severity.

  12. Radiation accidents.

    PubMed

    Saenger, E L

    1986-09-01

    It is essential that emergency physicians understand ways to manage patients contaminated by radioactive materials and/or exposed to external radiation sources. Contamination accidents require careful surveys to identify the metabolic pathway of the radionuclides to guide prognosis and treatment. The level of treatment required will depend on careful surveys and meticulous decontamination. There is no specific therapy for the acute radiation syndrome. Prophylactic antibodies are desirable. For severely exposed patients treatment is similar to the supportive care given to patients undergoing organ transplantation. For high-dose extremity injury, no methods have been developed to reverse the fibrosing endarteritis that eventually leads to tissue death so frequently found with this type of injury. Although the Three Mile Island episode of March 1979 created tremendous public concern, there were no radiation injuries. The contamination outside the reactor building and the release of radioiodine were negligible. The accidental fuel element meltdown at Chernobyl, USSR, resulted in many cases of acute radiation syndrome. More than 100,000 people were exposed to high levels of radioactive fallout. The general principles outlined here are applicable to accidents of that degree of severity. PMID:3526994

  13. Analysis of containment performance and radiological consequences under severe accident conditions for the Advanced Neutron Source Reactor at the Oak Ridge National Laboratory

    SciTech Connect

    Kim, S.H.; Taleyarkhan, R.P.

    1994-01-01

    A severe accident study was conducted to evaluate conservatively scoped source terms and radiological consequences to support the Advanced Neutron Source (ANS) Conceptual Safety Analysis Report (CSAR). Three different types of severe accident scenarios were postulated with a view of evaluating conservatively scoped source terms. The first scenario evaluates maximum possible steaming loads and associated radionuclide transport, whereas the next scenario is geared towards evaluating conservative containment loads from releases of radionuclide vapors and aerosols with associated generation of combustible gases. The third scenario follows the prescriptions given by the 10 CFR 100 guidelines. It was included in the CSAR for demonstrating site-suitability characteristics of the ANS. Various containment configurations are considered for the study of thermal-hydraulic and radiological behaviors of the ANS containment. Severe accident mitigative design features such as the use of rupture disks were accounted for. This report describes the postulated severe accident scenarios, methodology for analysis, modeling assumptions, modeling of several severe accident phenomena, and evaluation of the resulting source term and radiological consequences.

  14. [Free radical lipid peroxidation in clean-up workers from the Chernobyl nuclear reactor accident depending on working conditions in the area of radioactive contamination].

    PubMed

    D'iakova, A M; Liasko, L I; Sushkevich, G N; Poluéktova, M V; Chirkova, T V

    1994-01-01

    Plasma lipids and antioxidant defense factors were examined 5-6 years after the exposure in 49 subjects who had taken part in decontamination of the territories after the Chernobyl accident against those in non-exposed donors. Elevated levels of heptane-soluble lipoperoxides and of dienketones were registered, though malonic dialdehyde changed little. The above parameters deviated from the control level more in subjects exposed to higher ecological risk. In this group of examinees the antioxidant activity failed to neutralize lipoperoxide excess under low activity of plasma catalase. Antioxidant drugs are recommended to manage disorders of lipoperoxide homeostasis in subjects exposed to radiation as a result of Chernobyl accident.

  15. Solutions Network Formulation Report. Reducing Light Pollution in U.S. Coastal Regions Using the High Sensitivity Cameras on the SAC-C and Aquarius/SAC-D Satellites

    NASA Technical Reports Server (NTRS)

    Andrews, Jane C.; Knowlton, Kelly

    2007-01-01

    Light pollution has significant adverse biological effects on humans, animals, and plants and has resulted in the loss of our ability to view the stars and planets of the universe. Over half of the U.S. population resides in coastal regions where it is no longer possible to see the stars and planets in the night sky. Forty percent of the entire U.S. population is never exposed to conditions dark enough for their eyes to convert to night vision capabilities. In coastal regions, urban lights shine far out to sea where they are augmented by the output from fishing boat, cruise ship and oil platform floodlights. The proposed candidate solution suggests using HSCs (high sensitivity cameras) onboard the SAC-C and Aquarius/SAC-D satellites to quantitatively evaluate light pollution at high spatial resolution. New products modeled after pre-existing, radiance-calibrated, global nighttime lights products would be integrated into a modified Garstang model where elevation, mountain screening, Rayleigh scattering, Mie scattering by aerosols, and atmospheric extinction along light paths and curvature of the Earth would be taken into account. Because the spatial resolution of the HSCs on SAC-C and the future Aquarius/SAC-D missions is greater than that provided by the DMSP (Defense Meteorological Satellite Program) OLS (Operational Linescan System) or VIIRS (Visible/Infrared Imager/Radiometer Suite), it may be possible to obtain more precise light intensity data for analytical DSSs and the subsequent reduction in coastal light pollution.

  16. Soil Moisture Retrieval Using the Aquarius/SAC-D Instruments

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Aquarius/SAC-D will share common elements with several current and future satellite missions that provide soil moisture. Passive microwave soil moisture retrieval using low frequencies is currently performed using Aqua Advanced Microwave Scanning Radiometer-E (AMSR-E) (C/X-band). This will extended ...

  17. Placentation in mammals: Definitive placenta, yolk sac, and paraplacenta.

    PubMed

    Carter, A M; Enders, A C

    2016-07-01

    An overview is given of variations in placentation with particular focus on yolk sac, paraplacenta, and other structures important to histotrophic nutrition. The placenta proper varies in general shape, internal structure, and the number of tissues in the interhemal barrier. Yolk sac membranes persist to term in insectivores, colugos, rodents, and lagomorphs. In the latter two orders, they are of known importance for maternal-fetal transfer of antibodies, vitamins, lipids, and proteins. The detached yolk sac of bats is also active throughout gestation. A vascular paraplacenta, or smooth chorioallantois, has known functions in ruminants and carnivores and is found in several other orders of mammal where its function has yet to be explored. In human gestation, the chorion (avascular chorioallantois) is important for hormone synthesis. The true chorion of squirrels and hedgehogs is avascular but may nevertheless allow transfer from mother to fetus through the exocelom. Hemophagous areas with columnar trophoblast are paraplacental structures in carnivores and elephants but occur also within the placenta as in hyenas and moles. In shrews, it is the yolk sac that ingests and processes red cells. Areolas and chorionic vesicles are other structures important for absorption of uterine secretions and ingestion of cellular debris. In conclusion, we find that paraplacental structures, while showing less variation than the placenta proper, contribute not just to the integrity of overall placentation, but in various ways to maternal-fetal interrelationships. PMID:27155730

  18. The annular hematoma of the shrew yolk-sac placenta.

    PubMed

    King, B F; Enders, A C; Wimsatt, W A

    1978-05-01

    The annular hematoma of the shrew, Blarina brevicauda, is a specialized portion of the yolk-sac wall. In this study, we have examined the fine structure of the different cellular components of the anular hematoma. Small pieces of the gestation sacs from seven pregnant shrews were fixed in glutaraldehyde and osmium tetroxide and processed for transmission electron microscopy. In the area of the trophoblastic curtain, the maternal capillary endothelial cells were hypertrophied and syncytial trophoblast surrounded the capillaries. Cellular trophoblast covered part of the luminal surface of the curtain region, whereas masses of apparently degenerating syncytium were present on other areas of the surface. Maternal erythrocytes, released into the uterine lumen from the curtain region, were phagocytized and degraded by the columnar cells of the trophoblastic annulus. No evidence of iron or pigment accumulation was evident in the parietal endodermal cells underlying the annular trophoblast. Parietal endodermal cells were characterized by cuboidal shape, widely dilated intercellular spaces, and cytoplasm containing granular endoplasmic reticulum. Endodermal cells of the visceral yolk-sac accumulated large numbers of electron-dense granules as well as glycogen in their cytoplasm. Hemopoietic areas and vitelline capillaries were found subjacent to the visceral endoderm. The various portions of the yolk-sac wall of Blarina appear to perform complementary functions which are probably important in maternal-fetal iron transfer. PMID:677046

  19. TMACS Test Procedure TP008: SACS Interface. Revision 5

    SciTech Connect

    Washburn, S.J.

    1994-05-31

    The TMACS Software Project Test Procedures translate the project`s acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure tests the TMACS SACS Interface functions.

  20. Accident Flying Squad

    PubMed Central

    Snook, Roger

    1972-01-01

    This paper describes the organization, evaluation, and costing of an independently financed and operated accident flying squad. 132 accidents involving 302 casualties were attended, six deaths were prevented, medical treatment contributed to the survival of a further four, and the condition or comfort of many other casualties was improved. The calls in which survival was influenced were evenly distributed throughout the three-and-a-half-year survey and seven of the 10 so aided were over 16 and under 30 years of age, all 10 being in the working age group. The time taken to provide the service was not excessive and the expense when compared with the overall saving was very small. The scheme was seen to be equally suitable for basing on hospital or general practice or both, and working as an integrated team with the ambulance service. The use of specialized transport was found to be unnecessary. Other benefits of the scheme included use of the experience of attending accidents to ensure relevant and realistic training for emergency service personnel, and an appreciation of the effect of ambulance design on the patient. ImagesFIG. 1FIG. 4 PMID:5069642

  1. Dynamics of yolk sac resorption and post-hatching development of the gastrointestinal tract in chickens, ducks and geese.

    PubMed

    Jamroz, D; Wertelecki, T; Wiliczkiewicz, A; Orda, J; Skorupińska, J

    2004-06-01

    Under similar environmental conditions, 100 male Shaver-Starbro hybrid chickens, 100 male Mulard cross-line ducklings and 100 male Landaise goslings kept in 30 metabolic cages from the first day of life (10 birds of each species separately per cage) were chosen for the study. The animals were fed semi ad libitum diets with crude protein content and energy density similar to that used for poultry species, avoiding feed residues. During the first 21 days of life they received starter diets and from day 22 to 42 grower diets. Maize accounted for 23-40% and barley constituted 10-18%. Wheat accounted for 20.0% in starter diets and 10-18% in grower diets. Resorption of yolk sac residues, performance, development of the intestinal tract in young chickens, ducklings and goslings were assessed. During the first 5 days of life intensive absorption of yolk sac ingredients was observed. On day 7, residues of the yolk sac were found in more than 30% of chickens compared with approximately 10% in geese. In ducklings residues of the yolk sac were not found. On day 16 unabsorbed yolk sacs were found in approximately 10% of chickens. Liver and pancreas weighed the highest in geese and in ducks; in chickens the weight of these organs was significantly lower (p < 0.01). The relative values calculated to 100 g of metabolic body weight show that the average small intestine in chickens was significantly longer (p < 0.01) than in ducks or geese. The intestinal tract developed earlier in the chicken than in the water fowl.

  2. Efficacy of Several Pesticide Products on Brown Widow Spider (Araneae: Theridiidae) Egg Sacs and Their Penetration Through the Egg Sac Silk.

    PubMed

    Vetter, Richard S; Tarango, Jacob; Campbell, Kathleen A; Tham, Christine; Hayashi, Cheryl Y; Choe, Dong-Hwan

    2016-02-01

    Information on pesticide effects on spiders is less common than for insects; similar information for spider egg sacs is scarcer in the open literature. Spider egg sacs are typically covered with a protective silk layer. When pesticides are directly applied to egg sacs, the silk might prevent active ingredients from reaching the eggs, blocking their insecticidal effect. We investigated the impact of six water-based pesticide sprays and four oil-based aerosol products against egg sacs of brown widow spiders, Latrodectus geometricus C. L. Koch. All water-based spray products except one failed to provide significant mortality to egg sacs, resulting in successful spiderling emergence from treated egg sacs at a similar rate to untreated egg sacs. In contrast to water-based sprays, oil-based aerosols provided almost complete control, with 94-100% prevention of spiderling emergence. Penetration studies using colored pesticide products indicated that oil-based aerosols were significantly more effective in penetrating egg sac silk than were the water-based sprays, delivering the active ingredients on most (>99%) of the eggs inside the sac. The ability of pesticides to penetrate spider egg sac silk and deliver lethal doses of active ingredients to the eggs is discussed in relation to the chemical nature of egg sac silk proteins. Our study suggests that pest management procedures primarily relying on perimeter application of water-based sprays might not provide satisfactory control of brown widow spider eggs. Determination of the most effective active ingredients and carrier characteristics warrant further research to provide more effective control options for spider egg sacs.

  3. Investigation of sulfonated aromatic compound (SAC) modification to nylon film. 2. Study of SAC sorption isotherm and atomic force microscopic characterization of nylon surfaces

    SciTech Connect

    Zhang, J.; Watson, B.A.; Keown, R.W.; Malone, C.P.; Barteau, M.A.

    1995-08-01

    Nylon 6 and nylon 66 films have been treated with aqueous sulfonated aromatic compound (SAC) solutions at concentrations ranging from 0.005 to 1.0 wt%. SAC uptakes at different treatment concentrations were measured and found to follow a BET isotherm. The surface morphologies of nylon film samples, including the original and SAC-treated films, have been characterized by atomic force microscopy (AFM). For untreated nylon 6 and nylon 66 films, AFM images show a randomly distributed fibrillar surface structure. Characteristic widths of fibrils in the nylon 66 and 6 films were 150-225 and 75-150 nm, respectively. For SAC-treated nylon films, the AFM images revealed that the surfaces of the films became covered with nodule-like features having a diameter range of 25-60 nm. AFM analysis provides evidence that SAC treatment deposited a surface coating on nylon films. AFM images of SAC-treated nylon films suggest a mechanism for stain resistance in which the SAC first forms a thin coating on the nylon via bondings between attractive groups in the SAC and nylon polymers. After treatment at increased SAC concentration, the surface is covered with nodule-like deposits which likely serve as a physical barrier to dye permeation. 20 refs., 8 figs.

  4. Thermal hydraulic features of the TMI accident

    NASA Astrophysics Data System (ADS)

    Tolman, B.

    1985-10-01

    The Three Mile island (TMI)-2 accident resulted in extensive core damage and recent data confirms that the reactor vessel was challenged from molten core materials. A hypothesized TMI accident scenario is presented that consistently explains the TMI data and is also consistent with research findings from independent severe fuel damage experiments. The TMI data will prove useful in confirming our understanding of severe core damage accidents under realistic reactor systems conditions. This understanding will aid in addressing safety and regulatory issues related to severe core damage accidents in light water reactors.

  5. [Adenocarcinoma of the endolymphatic sac in children. A case report].

    PubMed

    Facon, F; Bruzzo, M; Figarella-Branger, D; Girard, N; Chays, A; Magnan, J

    2002-01-01

    We report a case of an adenocarcinoma of the endolymphatic sac in a 13 years old child, which was fortuitously discovered at the time of radiological investigation of growth delay. Arising from the end of the endolymphatic sac, this rare tumour shares a similar clinic expression with other cerebellopontine angle pathologies. Radiological investigation reveals a moth eaten appearance to the posterior temporal bone and specific bony inclusions. With MRI there is an intense and/or intermediate signal on T1, a hyper signal on T2 and T1 enhancement with injection of gadolinium. Treatment is surgical and local recurrences are not uncommon. After histological confirmation, a search for Von Hippel-Lindau disease is mandatory because this tumour is not exceptional among this subset of patients. Diagnosis and therapeutic criteria will be highlighted by our case and a review of the literature.

  6. Reformatted planar 'Christmas tree' MR appearance of the endolymphatic sac.

    PubMed

    Oehler, M C; Chakeres, D W; Schmalbrock, P

    1995-08-01

    A high-resolution three-dimensional Fourier transform technique and prototype bilateral dual phased-array surface coil technique was used to make inner ear structures visible on MR. Multiplanar reformatted images, parallel to the plane of the vestibular aqueduct, allowed viewing of the entire endolymphatic sac/vestibular aqueduct on one section, producing a "Christmas tree" shape. The reformation was obtained using a double oblique angle, 45 degrees from true sagittal and 70 degrees from the orbital-meatal axis.

  7. Endoscopic examination of snakes by access through an air sac.

    PubMed

    Jekl, V; Knotek, Z

    2006-03-25

    Sixteen boa constrictors (Boa constrictor), three royal pythons (Python regius) and 15 Burmese pythons (Python molurus bivittatus) were examined endoscopically by access through the air sac. The snakes were immobilised in a ventral position using a half-open anaesthetic system with assisted ventilation and a mixture of isoflurane and oxygen. The rigid endoscope was introduced percutaneously and the internal structure of the lungs and the air sac, and the shape, size and external surface of the liver were visible in the cranial direction. In the smaller snakes the bifurcation and caudal part of the trachea could be viewed, provided the endoscope was positioned in a retrograde orientation. The caudal orientation of the endoscope made it possible to view the gall bladder and the size, shape and surface of the spleen. In some cases, the pancreas and the surface of the stomach and colon could be monitored. Endoscopy through the air sac also made it possible to check the major veins in the coelom. The snakes were monitored for at least 30 days after the intervention and no changes in their respiratory function or general health were observed.

  8. Solitary fibrous tumors arising in abdominal wall hernia sacs.

    PubMed

    Lee, J R; Hancock, S M; Martindale, R G

    2001-06-01

    Solitary fibrous tumor (SFT) of the peritoneum is an unusual spindle-cell neoplasm. SFT was originally described in the pleura; however it is now diagnosed in multiple extrathoracic sites. Most believe that the tumor is of mesenchymal origin and should be classified as a variant of fibroma. SFT of the pleura and peritoneum have also been called fibrous mesothelioma, and the cell of origin is felt to be a pluripotential submesothelial mesenchymal cell. Primary tumors arising in hernia sacs are rare, and we report on two patients with hernia SFT. The first is a 67-year-old man who had a diffusely thickened distal left inguinal hernia sac. Within the sac was copious myxoid material mimicking pseudomyxoma peritonei. Herniorrhaphy and orchiectomy were performed. The second is a 44-year-old woman with a midepigastric mass attached to a ventral hernia. Wide local excision was performed. Both tumors demonstrated plump spindle cells, one with myxoid background and the other with keloidal collagen. Calretinin immunostaining was positive in both tumors, whereas CD34 was negative. This suggests tumor origin from a submesothial pluripotential cell that maintains potential for mesothelial differentiation. Surgical excision is the treatment of choice with the degree of resectability being a powerful predictor of outcome.

  9. Carcinoma of the anal sac glands in ranch mink.

    PubMed

    Hadlow, W J

    1985-05-01

    During a 14-year period, carcinoma of the anal sac apocrine glands was found in 52 pastel and 8 sapphire mink (Mustela vison) kept for studies on slow viral diseases. The pastel mink varied in age from 72 to 135 months (mean age 108 months), the sapphire mink from 63 to 100 months (mean age 81 months). All but one pastel mink were females. The primary tumor varied in size from masses that caused bulges in the perineum to those that were found only after microscopic examination of the anal sac glands. Although the primary tumor grew mainly by expansion with little local infiltration, 41 of the 60 tumors had metastasized to the regional lymph nodes and sometimes also to more distant sites. The striking propensity of the carcinoma to metastasize while still small, even microscopic, often resulted in massive secondary growths, notably in the iliac lymph nodes. Hypercalcemia did not accompany the carcinoma. Its varied microscopic appearance included solid, glandular, squamous cell, and spindle or round cell components. Combinations of them formed mixed or complex histologic patterns, no doubt largely attributable to neoplastic proliferation of myoepithelial cells and squamous metaplasia of the apocrine gland epithelium. Although its cause remains obscure, the carcinoma appeared to arise from small foci of hyperplastic apocrine glands, sometimes in relation to both anal sacs. The tumor is a common and distinctive expression of neoplasia in older ranch mink.

  10. Educational report: A case of lacrimal sac rhinosporidiosis.

    PubMed

    Jamison, Aaron; Crofts, Kevin; Roberts, Fiona; Gregory, Maria Elena

    2016-10-01

    This article reports a presentation of lacrimal sac rhinosporidiosis and informs the reader of this uncommon but important diagnosis. A 36-year-old man from Pakistan presented with a 3-month history of swelling at the nasal aspect of the left lower lid. This was associated with occasional crepitus and slight localised discomfort, but no epiphora. There was a palpable fullness near the left medial canthus associated with telecanthus but a normal sac washout and normal eye examination otherwise. Previous medical history included an ipsilateral nasal polypectomy and inferior meatal antrostomy around 10 years previously, whilst living in Pakistan. Various imaging modalities were useful in identifying a soft tissue mass within the left nasolacrimal duct. Following excision biopsy, histological examination confirmed the presence of rhinosporidiosis, likely caused by the organism Rhinosporidium seeberi. Rhinosporidiosis should be considered as a potential cause in any case of lacrimal sac pathology. Imaging studies may be helpful in measuring the extent of disease, although histological examination is required to confirm the diagnosis. Although rare, the complications of rhinosporidiosis can be potentially blinding or fatal. As discussed in this case, the presence of telecanthus may represent a lacrimal system tumour, either malignant or benign, and should always prompt further investigation. PMID:27541939

  11. Oblique sectional planes of block plastinates eased by Sac Plastination.

    PubMed

    Kürtül, Ibrahim; Hammer, Niels; Rabi, Suganthy; Saito, Toshiyuki; Böhme, Jörg; Steinke, Hanno

    2012-07-01

    To find an oblique cutting plane of a plastinate, e.g. to cut gamma-nails in the femur, the Block Plastination technique was modified. After CT and MRI examination, the specimens were plastinated with the standard resin mixture E6/E12/E600. Instead of using a box to form a block during the casting and curing stage, we embedded the specimen in a sac made of polyester foil. A polymerized wooden block was attached to the specimen. The sac was wrapped with tape to the embedded specimen with the block. This approach limited the amount of required resin to the inner volume of the plastinate. Then, the plastination sac was put in the incubator for further polymerization and curing. When the foil was removed from the plastinated specimen, the wooden block served as a socket for the grip when sawing. The outer shape of the specimen remained visible. Doing so, the adequate cutting plane could be determined easily. PMID:22209028

  12. Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids

    PubMed Central

    2012-01-01

    Sac family phosphoinositide phosphatases comprise an evolutionarily conserved family of enzymes in eukaryotes. Our recently determined crystal structure of the Sac phosphatase domain of yeast Sac1, the founding member of the Sac family proteins, revealed a unique conformation of the catalytic P-loop and a large positively charged groove at the catalytic site. We now report a unique mechanism for the regulation of its phosphatase activity. Sac1 is an allosteric enzyme that can be activated by its product phosphatidylinositol or anionic phospholipid phosphatidylserine. The activation of Sac1 may involve conformational changes of the catalytic P-loop induced by direct binding with the regulatory anionic phospholipids in the large cationic catalytic groove. These findings highlight the fact that lipid composition of the substrate membrane plays an important role in the control of Sac1 function. PMID:22452743

  13. World commercial aircraft accidents

    SciTech Connect

    Kimura, C.Y.

    1993-01-01

    This report is a compilation of all accidents world-wide involving aircraft in commercial service which resulted in the loss of the airframe or one or more fatality, or both. This information has been gathered in order to present a complete inventory of commercial aircraft accidents. Events involving military action, sabotage, terrorist bombings, hijackings, suicides, and industrial ground accidents are included within this list. Included are: accidents involving world commercial jet aircraft, world commercial turboprop aircraft, world commercial pistonprop aircraft with four or more engines and world commercial pistonprop aircraft with two or three engines from 1946 to 1992. Each accident is presented with information in the following categories: date of the accident, airline and its flight numbers, type of flight, type of aircraft, aircraft registration number, construction number/manufacturers serial number, aircraft damage, accident flight phase, accident location, number of fatalities, number of occupants, cause, remarks, or description (brief) of the accident, and finally references used. The sixth chapter presents a summary of the world commercial aircraft accidents by major aircraft class (e.g. jet, turboprop, and pistonprop) and by flight phase. The seventh chapter presents several special studies including a list of world commercial aircraft accidents for all aircraft types with 100 or more fatalities in order of decreasing number of fatalities, a list of collision accidents involving commercial aircrafts, and a list of world commercial aircraft accidents for all aircraft types involving military action, sabotage, terrorist bombings, and hijackings.

  14. Economic aspects of technological accidents: An evaluation of the Exxon Valdez oil spill on southcentral Alaska

    SciTech Connect

    Cohen, M.J.

    1993-01-01

    The potential of natural disasters to generate short-term economic benefits for impacted populations has become an accepted social science notion. The economic dimensions of human-made disasters have not received sufficient examination to justify a conclusive determination. Two analyses are conducted to examine the economic aspects of the Exxon Valdez oil spill on the communities of southcentral Alaska. First, a stochastic time-series model is employed to forecast the aggregate earnings that would have been achieved in the absence of the oil spill. This evaluation indicates that while the accident's proceeds were not distributed evenly across all communities in the affected region, this catastrophic event generated substantial aggregate monetary benefits in the short term. This analysis is followed by an examination of the oil spill's ex-vessel revenue impacts on each of southcentral Alaska's major fishery products (chinook, sockeye, coho, pink, chum, king crab, tanner crab, Dungeness crab, Pacific herring sac roe, Pacific halibut, and sablefish). The economic boom motivated by the oil spill obscured a decline in the profitability of commercial fishing and exacerbated deterioration of international market conditions for the region's fishery products. The accident reduced ex-vessel revenue for southcentral Alaska's commercial fishers during 1989 by an estimated amount between $6.1-$43.6 million. This analysis indicates that the oil spill's ex-vessel revenue impacts in 1990 were between $11.2-$44.9 million. In both years ex-vessel revenue reductions were greatest for sockeye and pink salmon, while increased ex-vessel prices for Pacific halibut and sablefish marginally mitigated these declines. Employing 1988 as a baseline, these amounts represent between 1.6-11.1 percent of the ex-vessel value of southcentral Alaska's commercial fishing economy. This evaluation provides a bounded interval in which one measure of the accident's economic dimensions can be considered.

  15. Designing an Experimental "Accident"

    ERIC Educational Resources Information Center

    Picker, Lester

    1974-01-01

    Describes an experimental "accident" that resulted in much student learning, seeks help in the identification of nematodes, and suggests biology teachers introduce similar accidents into their teaching to stimulate student interest. (PEB)

  16. Handling of psilocybin and psilocin by everted sacs of rat jejunum and colon.

    PubMed

    Eivindvik, K; Rasmussen, K E; Sund, R B

    1989-01-01

    Psilocybin and psilocin at luminal concentrations of about 20 nmol/ml were incubated aerobically with everted sacs from rat jejunum and colon. When incubation was terminated, samples of the lumen and blood side solutions and of the intestinal tissue were analyzed for parent drug and metabolites by HPLC using a multidetector system. Both sacs caused hydrolysis of psilocybin to psilocin, but the rate was much faster in the jejunum than in the colon. Tissue uptake of intact psilocybin was negligible or absent, and no transfer to the contraside of the parent drug could be demonstrated. In contrast, psilocin, whether formed by hydrolysis or added as a substrate, was well taken up by both intestinal segments and transferred to the blood side. In the colonic psilocybin experiments, this uptake and transfer was limited by a low hydrolytic rate. The results indicate that psilocybin under in vivo conditions is absorbed predominantly as psilocin. No further metabolism of either drug was observed, as opposed to the complex metabolism pattern that has been reported for serotonin, a close chemical relative to psilocin.

  17. Sac Angiography and Glue Embolization in Emergency Endovascular Aneurysm Repair for Ruptured Abdominal Aortic Aneurysm

    SciTech Connect

    Koike, Yuya Nishimura, Jun-ichi Hase, Soichiro Yamasaki, Motoshige

    2015-04-15

    PurposeThe purpose of this study was to demonstrate a sac angiography technique and evaluate the feasibility of N-butyl cyanoacrylate (NBCA) embolization of the ruptured abdominal aortic aneurysm (AAA) sac in emergency endovascular aneurysm repair (EVAR) in hemodynamically unstable patients.MethodsA retrospective case series of three patients in whom sac angiography was performed during emergency EVAR for ruptured AAA was reviewed. After stent graft deployment, angiography within the sac of aneurysm (sac angiography) was performed by manually injecting 10 ml of contrast material through a catheter to identify the presence and site of active bleeding. In two patients, sac angiography revealed active extravasation of the contrast material, and NBCA embolization with a coaxial catheter system was performed to achieve prompt sealing.ResultsSac angiography was successful in all three patients. In the two patients who underwent NBCA embolization for aneurysm sac bleeding, follow-up computed tomography (CT) images demonstrated the accumulation of NBCA consistent with the bleeding site in preprocedural CT images.ConclusionsEVAR is associated with a potential risk of ongoing bleeding from type II or IV endoleaks into the disrupted aneurysm sac in patients with severe coagulopathy. Therefore, sac angiography and NBCA embolization during emergency EVAR may represent a possible technical improvement in the treatment of ruptured AAA in hemodynamically unstable patients.

  18. Rhinosporidiosis of lacrimal sac: An interesting case of orbital swelling

    PubMed Central

    Basu, Sandip Kanti; Bain, Jayanta; Maity, Kuntal; Chattopadhyay, Debarati; Baitalik, Debasis; Majumdar, Bijay Kumar; Gupta, Vivek; Kumar, Ashwini; Dalal, Bibhas Saha; Malik, Anu

    2016-01-01

    Rhinosporidiosis is a chronic localized granulomatous disease caused by Rhinosporidium seeberi, an aquatic protistan parasite belonging to a clade, Mesomycetozoea. Infestation of Rhinosporidiosis to the eye and adnexa is termed oculosporidiosis, in such cases, conjunctival mucosa is mostly involved; however in our case, it involved only the lacrimal sac and deeper periorbital tissue and presented as a case of orbital swelling. Surgical excision of the lesion was done, postoperatively dapsone therapy was given for 6 months, and the patient responded very well with no recurrence till date. PMID:27003980

  19. Venous Sac Embolization of Pulmonary Arteriovenous Malformation: Preliminary Experience Using Interlocking Detachable Coils

    SciTech Connect

    Takahashi, Koji; Tanimura, Keiichi; Honda, Masanori; Kikuno, Motoyuki; Toei, Hisao; Hyodoh, Hideki; Furuse, Makoto; Yamada, Tomonori; Aburano, Tamio

    1999-05-15

    Purpose: To evaluate the indication and advantages of venous sac embolization of pulmonary arteriovenous malformations (PAVMs) using interlocking detachable coils (IDCs). Methods: We performed percutaneous embolization in 12 PAVMs in four patients using IDCs, initially placed in the venous sac or at the feeding artery to prevent systemic migration of additional coils. We placed the IDCs in the venous sac in PAVMs with the following vascular architecture: the draining vein was larger than the feeding arteries and both vessels were interposed with the venous sac or there were short feeding arteries. Results: Complete occlusion was achieved in all 12 PAVMs without significant complications. We deployed IDCs in the venous sac in eight PAVMs and in the feeding artery in four. Conclusion: Venous sac embolization may be beneficial in PAVMs with large out-flow vessels or short feeding arteries. IDCs are suitable for this procedure.

  20. The SAC51 Family Plays a Central Role in Thermospermine Responses in Arabidopsis.

    PubMed

    Cai, Qingqing; Fukushima, Hiroko; Yamamoto, Mai; Ishii, Nami; Sakamoto, Tomoaki; Kurata, Tetsuya; Motose, Hiroyasu; Takahashi, Taku

    2016-08-01

    The acaulis5 (acl5) mutant of Arabidopsis thaliana is defective in the biosynthesis of thermospermine and shows a dwarf phenotype associated with excess xylem differentiation. SAC51 was identified from a dominant suppressor of acl5, sac51-d, and encodes a basic helix-loop-helix protein. The sac51-d mutant has a premature termination codon in an upstream open reading frame (uORF) that is conserved among all four members of the SAC51 family, SAC51 and SACL1-SACL3 This suggests that thermospermine cancels the inhibitory effect of the uORF in main ORF translation. Another suppressor, sac57-d, has a mutation in the conserved uORF of SACL3 To define further the function of the SAC51 family in the thermospermine response, we analyzed T-DNA insertion mutants of each gene. Although sacl1-1 may not be a null allele, the quadruple mutant showed a semi-dwarf phenotype but with an increased level of thermospermine and decreased sensitivity to exogenous thermospermine that normally represses xylem differentiation. The sac51-1 sacl3-1 double mutant was also insensitive to thermospermine. These results suggest that SAC51 and SACL3 play a key role in thermospermine-dependent negative control of thermospermine biosynthesis and xylem differentiation. Using 5' leader-GUS (β-glucuronidase) fusion constructs, however, we detected a significant enhancement of the GUS activity by thermospermine only in SAC51 and SACL1 constructs. Furthermore, while acl5-1 sac51-1 showed the acl5 dwarf phenotype, acl5-1 sacl3-1 exhibited an extremely tiny-plant phenotype. These results suggest a complex regulatory network for the thermospermine response in which SAC51 and SACL3 function in parallel pathways. PMID:27388339

  1. Pilot-error accidents: male vs female.

    PubMed

    Vail, G J; Ekman, L G

    1986-12-01

    In this study, general aviation accident records from the files of the National Transportation Safety Board (NTSB), have been analysed by gender to observe the number and rate of pilot-error related accidents from 1972 to 1981 inclusive. If both females and males have no difference in performance, then data would have indicated similarities of accident rates and types of injuries. Males had a higher rate of accidents than females, and a higher portion of the male accidents resulted in fatalities or serious injuries than for females. Type of certificate, age, total flight time, flight time in type of aircraft, phase of operation, category of flying, degree of injury, specific cause factors, cause factor miscellaneous acts/conditions were analysed, taking the total number of United States Active Civilian General Aviation Pilots into consideration. The data did indicate a difference in all variables.

  2. Ruptured yolk sacs and visceral fungi in emergent pink salmon alevins: histopathology and relation to marine survival.

    PubMed

    Marty, Gary D; Heintz, Ronald A

    2010-01-25

    Marine survival of anadromous salmon species is highly variable, and causes of this variability are often unknown. In the 1990s, cultured pink salmon Oncorhynchus gorbuscha alevins from 2 different regions in Alaska, USA, had years with increased postemergent mortality that could not be attributed to viruses, bacteria, or parasites. In both regions, lifetime marine survival of the most severely affected fish groups was as low as 1.1% in 1 region and 0.13% in the other region. To determine causes of morbidity, alevins from both regions were sampled for detailed histopathology (n = 144 and 36). Microscopic lesions associated with increased postemergent mortality included ruptured yolk sacs or 'coagulated yolk' (up to 38% of abnormal fish affected) and invasive fungi in the stomach or swimbladder (up to 39% of abnormal fish affected). The diagnosis of a ruptured yolk sac was based on the presence of yolk protein in the peritoneal cavity. Putative yolk proteins sometimes also distended peritoneal macrophages, systemic vessels, hepatocyte cytoplasm, splenic macrophages, and renal ducts. The most severe case of visceral fungi had hyphae invading from the stomach into the swimbladder and kidney. In the hatchery with the greatest postemergent mortality, 38% of the abnormal fish sampled had no significant microscopic lesions. We hypothesize that ruptured yolk sacs and visceral fungi occurred in fish that were predisposed to develop these lesions because of poor body condition. High prevalence of these lesions might be a useful marker for predicting poor marine survival. PMID:20225673

  3. Cross-analysis of hazmat road accidents using multiple databases.

    PubMed

    Trépanier, Martin; Leroux, Marie-Hélène; de Marcellis-Warin, Nathalie

    2009-11-01

    Road selection for hazardous materials transportation relies heavily on risk analysis. With risk being generally expressed as a product of the probability of occurrence and the expected consequence, one will understand that risk analysis is data intensive. However, various authors have noticed the lack of statistical reliability of hazmat accident databases due to the systematic underreporting of such events. Also, official accident databases alone are not always providing all the information required (economical impact, road conditions, etc.). In this paper, we attempt to integrate many data sources to analyze hazmat accidents in the province of Quebec, Canada. Databases on dangerous goods accidents, road accidents and work accidents were cross-analyzed. Results show that accidents can hardly be matched and that these databases suffer from underreporting. Police records seem to have better coverage than official records maintained by hazmat authorities. Serious accidents are missing from government's official databases (some involving deaths or major spills) even though their declaration is mandatory.

  4. Cross-analysis of hazmat road accidents using multiple databases.

    PubMed

    Trépanier, Martin; Leroux, Marie-Hélène; de Marcellis-Warin, Nathalie

    2009-11-01

    Road selection for hazardous materials transportation relies heavily on risk analysis. With risk being generally expressed as a product of the probability of occurrence and the expected consequence, one will understand that risk analysis is data intensive. However, various authors have noticed the lack of statistical reliability of hazmat accident databases due to the systematic underreporting of such events. Also, official accident databases alone are not always providing all the information required (economical impact, road conditions, etc.). In this paper, we attempt to integrate many data sources to analyze hazmat accidents in the province of Quebec, Canada. Databases on dangerous goods accidents, road accidents and work accidents were cross-analyzed. Results show that accidents can hardly be matched and that these databases suffer from underreporting. Police records seem to have better coverage than official records maintained by hazmat authorities. Serious accidents are missing from government's official databases (some involving deaths or major spills) even though their declaration is mandatory. PMID:19819367

  5. Drug uptake into everted intestinal sacs. I. Enhancement by hypertonicity.

    PubMed

    Hurwitz, A; Gutman, Y

    1979-01-01

    The transfer of the cationic drugs, pralidoxime (PAM) and tetraethylammonium, and anionic ampicillin from the mucosal-to-serosal sides of everted rat jejunal sacs is enhanced by mucosal hypertonicity. PAM uptake, which is proportional to initial mucosal concentrations up to 2.3 mM, is enhanced by mucosal hypertonicity due to addition of sodium, potassium, lithium and choline chloride, sodium sulfate, and the nonionic solutes, urea, sucrose, and mannitol. Bicarbonate, Tris, or phosphate buffer and the presence of magnesium and calcium do not affect this hypertonicity-induced acceleration of PAM passage. Serosal osmolality has no effect on transfer and mucosal hypertonicity is equally effective in the presence and absence of a transmural osmotic gradient. This observation and minimal changes in the concentration of inulin placed in the sacs suggest that fluid shifts and solvent drag are not responsible for the enhanced mucosal-to-serosal transfer of PAM from hypertonic buffer. Mucosal hypertonicity at 450 mosmol/kg causes reversible enhancement of PAM transfer, whereas the effect of 600 mosmol/kg cannot be reversed by replacing the tissue in isotonic buffer. The effect of osmotic manipulation on PAM transfer across the intestine thus differs from its effect on the passage of other ionized species and drugs across other epithelia. PMID:434150

  6. Glucocorticoid and progesterone receptors in yolk sac placenta.

    PubMed

    Carbone, J P; Baldridge, R C; Magen, A B; Andrew, C L; Koszalka, T R; Brent, R L

    1986-01-01

    The parietal yolk sac (PYS) of the rat fetus at the 14th day of gestation contains glucocorticoid as well as progesterone receptors; both are present in the trophoblast cell layer. Following heat activation the receptors are capable of binding to deoxyribonucleic acid- (DNA-)cellulose. Glucocorticoid receptors, but not progesterone receptors, are also present in the visceral yolk sac (VYS) at the 14th day of gestation. Greater amounts (some 250 femtomoles/mg cytosol protein) of a glucocorticoid receptor are present in the VYS on the 17th day of gestation. The Kd is approximately 4 X 10(-9) M; following activation it also binds to DNA-cellulose. The elution pattern of the activated VYS receptor from diethylaminoethyl-(DEAE-)Sephadex, however, is similar to that found with kidney and colon rather than that of liver (i.e., it resembles corticosteroid binder IB rather than binder II) indicating a possible role in transport. Although the receptors are separate entities, progesterone competes as effectively as corticosterone for binding to the glucocorticoid receptors in both the PYS and and VYS, thus raising the question of the possible effect of changes in progesterone concentrations on the functioning of glucocorticoids during development.

  7. [Absorption of extractive Polygonum orientale in rat everted gut sacs].

    PubMed

    Liu, Yue; Tang, Li; Cao, Xu; Zheng, Lin; Wang, Ai-Min; Huang, Yong

    2014-06-01

    Using in vitro everted gut to investigate the intestinal absorption of the extracts from Polygonum orientale at different concentration. UPLC-MS/MS was used to detect the content of protocatechuic acid, isoorientin, orientin, vitexin, cynaroside, quercitrin, kaempferol-rhamnoside in different intestinal segments, then compared the results with the absorption of chemical components of extractive P. orientale in each intestinal segments, and calculated the absorption parameter. We took the statistic analysis with SPSS statistic software. The influence significance of each factors were analyzed to describe the character of absorption. The absorption of each component is linearity in different intestinal segments and different dose, and the square of coeficient correlation exceed 0.95, which consistent with zero order rate process. The K(a) increase along with the raised dosage of the extractive P. orientale (R2 > 0.95), indicated it is the passive absorption; different intestinal segments have different absorption. And the absorption trend in intestinal is duodenum, jejunum, ileum are greater than the colon. As ingredients are selectively absorbed in intestinal sac, the everted intestinal sac method is selected to assess the intestinal absorption charcteristics of ingredients of extractive P. orientale. PMID:25272855

  8. Angiotropic lymphoma occurring in a lacrimal sac oncocytoma.

    PubMed

    O'Connor, S R; Tan, J H-Y; Walewska, R; Brown, L J R; Lauder, I

    2002-10-01

    This report describes a case of angiotropic variant of diffuse large B cell lymphoma within a benign oncocytoma of the lacrimal sac. The occurrence of this rare lymphoma within a benign neoplasm has not been documented previously. An 87 year old woman presented with a swelling over the area of the left lacrimal sac, which histological examination revealed to be an oncocytoma. Many small blood vessels within the tumour were filled with large cytologically atypical cells, which stained positively for leucocyte common antigen and a B cell antigen, CD20, confirming the presence of a large B cell non-Hodgkin's lymphoma of angiotropic type. Angiotropic lymphoma is a very rare and usually highly aggressive variant of non-Hodgkin's lymphoma, which classically involves the central nervous system and skin, but has been described within most organs. Its occurrence within a benign neoplasm is probably coincidental, although a close association between oncocytic epithelium and normal lymphoid cells is recognised in Warthin's tumour of salivary and lacrimal glands.

  9. Potentiodynamic polarization effect on phase and microstructure of SAC305 solder in hydrochloric acid solution

    NASA Astrophysics Data System (ADS)

    Zaini, Nurwahida Binti Mohd; Nazeri, Muhammad Firdaus Bin Mohd

    2016-07-01

    The corrosion analysis of SAC305 lead free solder was investigated in Hydrochloric acid (HCl) solution. Potentiodynamic polarization was used to polarize the SAC305. The effect of polarization on the phase and microstructure were compared to as-prepared SAC305 solder. Potentiodynamic polarization introduces mixed corrosion products on the surface of SAC305 solder. The XRD analysis confirms that the mixed corrosion products emerged on the surface after polarization by formation of SnO and SnO2 of which confirmed that dissolution of Sn was dominant during polarization. Microstructure analysis reveal the presence of gap and porosities produced limits the protection offered by the passivation film.

  10. The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines

    SciTech Connect

    Ikonomov, Ognian C. Filios, Catherine Sbrissa, Diego Chen, Xuequn Shisheva, Assia

    2013-10-18

    Highlights: •We assess PAS complex proteins and phosphoinositide levels in breast cancer cells. •Sac3 and ArPIKfyve are markedly elevated in triple-negative breast cancer cells. •Sac3 silencing inhibits proliferation in triple-negative breast cancer cell lines. •Phosphoinositide profiles are altered in breast cancer cells. •This is the first evidence linking high Sac3 with breast cancer cell proliferation. -- Abstract: The phosphoinositide 5-kinase PIKfyve and 5-phosphatase Sac3 are scaffolded by ArPIKfyve in the PIKfyve–ArPIKfyve–Sac3 (PAS) regulatory complex to trigger a unique loop of PtdIns3P–PtdIns(3,5)P{sub 2} synthesis and turnover. Whereas the metabolizing enzymes of the other 3-phosphoinositides have already been implicated in breast cancer, the role of the PAS proteins and the PtdIns3P–PtdIns(3,5)P{sub 2} conversion is unknown. To begin elucidating their roles, in this study we monitored the endogenous levels of the PAS complex proteins in cell lines derived from hormone-receptor positive (MCF7 and T47D) or triple-negative breast cancers (TNBC) (BT20, BT549 and MDA-MB-231) as well as in MCF10A cells derived from non-tumorigenic mastectomy. We report profound upregulation of Sac3 and ArPIKfyve in the triple negative vs. hormone-sensitive breast cancer or non-tumorigenic cells, with BT cell lines showing the highest levels. siRNA-mediated knockdown of Sac3, but not that of PIKfyve, significantly inhibited proliferation of BT20 and BT549 cells. In these cells, knockdown of ArPIKfyve had only a minor effect, consistent with a primary role for Sac3 in TNBC cell proliferation. Intriguingly, steady-state levels of PtdIns(3,5)P{sub 2} in BT20 and T47D cells were similar despite the 6-fold difference in Sac3 levels between these cell lines. However, steady-state levels of PtdIns3P and PtdIns5P, both regulated by the PAS complex, were significantly reduced in BT20 vs. T47D or MCF10A cell lines, consistent with elevated Sac3 affecting directly or

  11. Global estimates of fatal occupational accidents.

    PubMed

    Takala, J

    1999-09-01

    Data on occupational accidents are not available from all countries in the world. Furthermore, underreporting, limited coverage by reporting and compensation schemes, and non-harmonized accident recording and notification systems undermine efforts to obtain worldwide information on occupational accidents. This paper presents a method and new estimated global figures of fatal accidents at work by region. The fatal occupational accident rates reported to the International Labour Office are extended to the total employed workforce in countries and regions. For areas not covered by the reported information, rates from other countries that have similar or comparable conditions are applied. In 1994, an average estimated fatal occupational accident rate in the whole world was 14.0 per 100,000 workers, and the total estimated number of fatal occupational accidents was 335,000. The rates are different for individual countries and regions and for separate branches of economic activity. In conclusion, fatal occupational accident figures are higher than previously estimated. The new estimates can be gradually improved by obtaining and adding data from countries where information is not yet available. Sectoral estimates for at least key economic branches in individual countries would further increase the accuracy.

  12. Visualization of Traffic Accidents

    NASA Technical Reports Server (NTRS)

    Wang, Jie; Shen, Yuzhong; Khattak, Asad

    2010-01-01

    Traffic accidents have tremendous impact on society. Annually approximately 6.4 million vehicle accidents are reported by police in the US and nearly half of them result in catastrophic injuries. Visualizations of traffic accidents using geographic information systems (GIS) greatly facilitate handling and analysis of traffic accidents in many aspects. Environmental Systems Research Institute (ESRI), Inc. is the world leader in GIS research and development. ArcGIS, a software package developed by ESRI, has the capabilities to display events associated with a road network, such as accident locations, and pavement quality. But when event locations related to a road network are processed, the existing algorithm used by ArcGIS does not utilize all the information related to the routes of the road network and produces erroneous visualization results of event locations. This software bug causes serious problems for applications in which accurate location information is critical for emergency responses, such as traffic accidents. This paper aims to address this problem and proposes an improved method that utilizes all relevant information of traffic accidents, namely, route number, direction, and mile post, and extracts correct event locations for accurate traffic accident visualization and analysis. The proposed method generates a new shape file for traffic accidents and displays them on top of the existing road network in ArcGIS. Visualization of traffic accidents along Hampton Roads Bridge Tunnel is included to demonstrate the effectiveness of the proposed method.

  13. Chemical factors affecting fission product transport in severe LMFBR accidents

    SciTech Connect

    Wichner, R.P.; Jolley, R.L.; Gat, U.; Rodgers, B.R.

    1984-10-01

    This study was performed as a part of a larger evaluation effort on LMFBR accident, source-term estimation. Purpose was to provide basic chemical information regarding fission product, sodium coolant, and structural material interactions required to perform estimation of fission product transport under LMFBR accident conditions. Emphasis was placed on conditions within the reactor vessel; containment vessel conditions are discussed only briefly.

  14. Laser accidents: Being Prepared

    SciTech Connect

    Barat, K

    2003-01-24

    The goal of the Laser Safety Officer and any laser safety program is to prevent a laser accident from occurring, in particular an injury to a person's eyes. Most laser safety courses talk about laser accidents, causes, and types of injury. The purpose of this presentation is to present a plan for safety offices and users to follow in case of accident or injury from laser radiation.

  15. Contribution to the description of the absorber rod behavior in severe accident conditions: An experimental investigation of the Ag-Zr phase diagram

    NASA Astrophysics Data System (ADS)

    Decreton, A.; Benigni, P.; Rogez, J.; Mikaelian, G.; Barrachin, M.; Lomello-Tafin, M.; Antion, C.; Janghorban, A.; Fischer, E.

    2015-10-01

    Most pressurized water reactor (PWR) absorber rods are composed of an Ag-In-Cd (SIC) alloy inside a stainless steel (SS) cladding, themselves inserted into a Zircaloy tube. During a severe accident, the SIC alloy which melts at 800 °C does not practically interact with SS. However, the cladding failure results from its internal pressurization and its eutectic interaction with Zircaloy and occurs at temperatures greater than 1200 °C. The subsequent interaction between the SIC melt and the Zircaloy has a strong impact on the quantities of aerosols released into the primary circuit and finally on the iodine chemistry. Accurate knowledge of the Ag-Zr system is a prerequisite to address this issue. Within this concern, our experimental work is focused both on the investigation of the Ag-Zr phase diagram and on the determination of the thermodynamic properties of the intermetallic compounds in the system. Two intermetallic compounds (AgZr and AgZr2) were identified. Ag-Zr cast alloys with a Ag/Zr ratio of 1:1 elaborated using an arc-melting furnace, once annealed, contained only a single phase AgZr. From metallographic observations, it appears that AgZr2 likely forms by the peritectic reaction from liquid and the bcc (βZr) phase. The partial enthalpies of solution of silver and zirconium in aluminum were experimentally determined at 723 °C in order to determine the enthalpies of formation of the intermetallic compounds. For silver solution calorimetry in aluminum bath, our measurements were successful and in agreement with the previous data. Yet, this study shows that liquid aluminum should not be used as a solvent for zirconium below 1000 °C.

  16. Clearance of chlamydial elementary bodies from the conjunctival sac

    SciTech Connect

    Taylor, H.R.; Velez, V.L.

    1987-07-01

    The rate of disappearance of inactivated Chlamydia trachomatis elementary body (EB) preparations from the conjunctival sac was studied in monkeys. Direct fluorescent antibody (DFA) cytology showed that the majority of EB had been cleared from the eye within 24 hr of the inoculation of 1 X 10(6) inactivated EB, although small numbers of EB could be detected for up to 144 hr. The rate of clearance in normal and ocular immune animals did not differ, and formalin-killed and UV-inactivated EBs disappeared at a comparable rate. These studies suggest that chlamydial EB are cleared relatively quickly from the eye and support the notion that EBs detected by DFA cytology indicate the presence of current infection.

  17. Endometriosis within a left-sided inguinal hernia sac

    PubMed Central

    Albutt, Katherine; Glass, Charity; Odom, Stephen; Gupta, Alok

    2014-01-01

    Endometriosis is a common gynecologic disorder wherein ectopic endometrial glands and stroma are found at extrauterine sites. Extrapelvic endometriosis is a well-documented, yet rare, disease entity that can affect almost any organ system. Inguinal endometriosis is an extremely rare disease entity characterized by tender inguinal swelling. Here we report a case of a sudden-onset and acutely painful left inguinal hernia with concordant endometriosis. A review of the literature is presented. The presence of isolated endometriosis contained within a left-sided inguinal hernia sac has, to our knowledge, never been reported. Often diagnosed incidentally or on histologic examination, general surgeons should consider inguinal endometriosis in the differential diagnosis of inguinal masses, even in the absence of catamenial symptoms. Surgical excision, with gynecologic follow-up, is locally curative and the treatment of choice for inguinal endometriosis. PMID:24876515

  18. The influence of locomotion on air-sac pressures in little penguins.

    PubMed

    Boggs, D F; Baudinette, R V; Frappell, P B; Butler, P J

    2001-10-01

    Air-sac pressures have been reported to oscillate with wing beat in flying magpies and with foot paddling in diving ducks. We sought to determine the impact on air-sac pressure of wing beats during swimming and of the step cycle during walking in little penguins (Eudyptula minor). Fluctuations averaged 0.16+/-0.06 kPa in the interclavicular air sacs, but only 0.06+/-0.04 kPa in the posterior thoracic sac, generating a small differential pressure between sacs of 0.06+/-0.02 kPa (means +/- S.E.M., N=4). These fluctuations occurred at approximately 3 Hz and corresponded to wing beats during swimming, indicated by electromyograms from the pectoralis and supracoracoideus muscles. There was no abdominal muscle activity associated with swimming or exhalation, but the abdominal muscles were active with the step cycle in walking penguins, and oscillations in posterior air-sac pressure (0.08+/-0.038 kPa) occurred with steps. We conclude that high-frequency oscillations in differential air-sac pressure enhance access to and utilization of the O(2) stores in the air sacs during a dive. PMID:11707507

  19. Involvement of Sac1 phosphoinositide phosphatase in the metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae.

    PubMed

    Tani, Motohiro; Kuge, Osamu

    2014-04-01

    Sac1 is a phosphoinositide phosphatase that preferentially dephosphorylates phosphatidylinositol 4-phosphate. Mutation of SAC1 causes not only the accumulation of phosphoinositides but also reduction of the phosphatidylserine (PS) level in the yeast Saccharomyces cerevisiae. In this study, we characterized the mechanism underlying the PS reduction in SAC1-deleted cells. Incorporation of (32) P into PS was significantly delayed in sac1∆ cells. Such a delay was also observed in SAC1- and PS decarboxylase gene-deleted cells, suggesting that the reduction in the PS level is caused by a reduction in the rate of biosynthesis of PS. A reduction in the PS level was also observed with repression of STT4 encoding phosphatidylinositol 4-kinase or deletion of VPS34 encoding phophatidylinositol 3-kinase. However, the combination of mutations of SAC1 and STT4 or VPS34 did not restore the reduced PS level, suggesting that both the synthesis and degradation of phosphoinositides are important for maintenance of the PS level. Finally, we observed an abnormal PS distribution in sac1∆ cells when a specific probe for PS was expressed. Collectively, these results suggested that Sac1 is involved in the maintenance of a normal rate of biosynthesis and distribution of PS.

  20. Finite element analysis of stresses developed in the blood sac of a left ventricular assist device.

    PubMed

    Haut Donahue, T L; Dehlin, W; Gillespie, J; Weiss, W J; Rosenberg, G

    2009-05-01

    The goal of this research is to develop a 3D finite element (FE) model of a left ventricular assist device (LVAD) to predict stresses in the blood sac. The hyperelastic stress-strain curves for the segmented poly(ether polyurethane urea) (SPEUU) blood sac were determined in both tension and compression using a servo-hydraulic testing system at various strain rates. Over the range of strain rates studied, the sac was not strain rate sensitive, however the material response was different for tension versus compression. The experimental tension and compression properties were used in a FE model that consisted of the pusher plate, blood sac and pump case. A quasi-static analysis was used to allow for nonlinearities due to contact and material deformation. The 3D FE model showed that blood sac stresses are not adversely affected by the location of the inlet and outlet ports of the device and that over the systolic ejection phase of the simulation the prediction of blood sac stresses from the full 3D model and an axisymmetric model are the same. Minimizing stresses in the blood sac will increase the longevity of the blood sac in vivo. PMID:19131267

  1. 74. SAC control center addition sect 9top three floors, first ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. SAC control center addition sect 9-top three floors, first floor plan, drawing number AS-BLT.AW30-02-03, dated May, 1958 - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  2. Mammalian laryngseal air sacs add variability to the vocal tract impedance: Physical and computational modeling

    PubMed Central

    Riede, Tobias; Tokuda, Isao T.; Munger, Jacob B.; Thomson, Scott L.

    2008-01-01

    Cavities branching off the main vocal tract are ubiquitous in nonhumans. Mammalian air sacs exist in human relatives, including all four great apes, but only a substantially reduced version exists in humans. The present paper focuses on acoustical functions of the air sacs. The hypotheses are investigated on whether the air sacs affect amplitude of utterances and∕or position of formants. A multilayer synthetic model of the vocal folds coupled with a vocal tract model was utilized. As an air sac model, four configurations were considered: open and closed uniform tube-like side branches, a rigid cavity, and an inflatable cavity. Results suggest that some air sac configurations can enhance the sound level. Furthermore, an air sac model introduces one or more additional resonance frequencies, shifting formants of the main vocal tract to some extent but not as strongly as previously suggested. In addition, dynamic range of vocalization can be extended by the air sacs. A new finding is also an increased variability of the vocal tract impedance, leading to strong nonlinear source-filter interaction effects. The experiments demonstrated that air-sac-like structures can destabilize the sound source. The results were validated by a transmission line computational model. PMID:18647005

  3. TMI-2 accident: core heat-up analysis

    SciTech Connect

    Ardron, K.H.; Cain, D.G.

    1981-01-01

    This report summarizes NSAC study of reactor core thermal conditions during the accident at Three Mile Island, Unit 2. The study focuses primarily on the time period from core uncovery (approximately 113 minutes after turbine trip) through the initiation of sustained high pressure injection (after 202 minutes). The transient analysis is based upon established sequences of events; plant data; post-accident measurements; interpretation or indirect use of instrument responses to accident conditions.

  4. pH sensing via bicarbonate-regulated “soluble” adenylyl cyclase (sAC)

    PubMed Central

    Rahman, Nawreen; Buck, Jochen; Levin, Lonny R.

    2013-01-01

    Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3′, 5′ monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO−3) ions. In living cells, HCO−3 ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO−3, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role. PMID:24324443

  5. Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia

    NASA Technical Reports Server (NTRS)

    Yoshihara, T.; Kaname, H.; Narita, N.; Ishii, T.; Igarashi, M.; Fermin, C. D.

    1992-01-01

    The endolymphatic sac of chick embryos (from embryonic day 7 to 1-day-old chicks) was studied light- and electron-microscopically. At stage 30-31 (embryonic day 7-7.5), the epithelial cells of the endolymphatic sac were cuboidal to columnar in shape. Microvilli were relatively well developed. The intercellular space was wide. In the endolymphatic space of the endolymphatic sac, varying shapes and sizes of otoconia-like bodies were often observed. Intracytoplasmic phagosomes containing these bodies were rarely found. After stage 37 (embryonic day 11), otoconia-like bodies in the endolymphatic sac decreased in number and size. They were almost the same as the otoconia in the macular organs, ultrastructurally. These findings indicate that the endolymphatic sac of the chick embryos may possess the function of otoconial degradation and removal of calcium from otoconia.

  6. Civil aircraft accident investigation.

    PubMed

    Haines, Daniel

    2013-01-01

    This talk reviews some historic aircraft accidents and some more recent. It reflects on the division of accident causes, considering mechanical failures and aircrew failures, and on aircrew training. Investigation results may lead to improved aircraft design, and to appropriate crew training. PMID:24057309

  7. Anatomy of an Accident.

    ERIC Educational Resources Information Center

    Mobley, Michael

    1984-01-01

    The findings of industrial safety engineers in the areas of accident causation and prevention are wholly applicable to adventure programs. Adventure education instructors can use safety engineering concepts to assess the risk in a particular activity, understand factors that cause accidents, and intervene to minimize injuries and damages if…

  8. Farm accidents in children.

    PubMed Central

    Cameron, D.; Bishop, C.; Sibert, J. R.

    1992-01-01

    OBJECTIVE--To examine the problem of accidental injury to children on farms. DESIGN--Prospective county based study of children presenting to accident and emergency departments over 12 months with injuries sustained in a farm setting and nationwide review of fatal childhood farm accidents over the four years April 1986 to March 1990. SETTING--Accident and emergency departments in Aberystwyth, Carmarthen, Haverfordwest, and Llanelli and fatal accidents in England, Scotland, and Wales notified to the Health and Safety Executive register. SUBJECTS--Children aged under 16. MAIN OUTCOME MEASURE--Death or injury after farm related accidents. RESULTS--65 accidents were recorded, including 18 fractures. Nine accidents necessitated admission to hospital for a mean of two (range one to four) days. 13 incidents were related to tractors and other machinery; 24 were due to falls. None of these incidents were reported under the statutory notification scheme. 33 deaths were notified, eight related to tractors and allied machinery and 10 related to falling objects. CONCLUSIONS--Although safety is improving, the farm remains a dangerous environment for children. Enforcement of existing safety legislation with significant penalties and targeting of safety education will help reduce accident rates further. PMID:1638192

  9. Enhanced expression of an endoglucanase in Bacillus subtilis by using the sucrose-inducible sacB promoter and improved properties of the recombinant enzyme.

    PubMed

    Liu, Sen-Lin; Du, Kun

    2012-06-01

    An endoglucanase from Bacillus akibai I-1 was successfully overexpressed in Bacillus subtilis 168 and the expression level of the recombinant enzyme was greatly enhanced by using the sucrose-inducible sacB promoter. The endoglucanase activity in the culture supernatant of recombinant B. subtilis by using itself promoter (HpaII) in plasmid pMA5 was 3U/ml. Interestingly, with the addition of sacB promoter at downstream from the HpaII promoter or the replacement of HpaII promoter by the sacB promoter, the endoglucanase activities reached 62 and 60U/ml, respectively, under the optimal culture conditions. These results demonstrated that the sacB promoter might be more efficient for the expression of the endoglucanase than the HpaII promoter. More interestingly, the purified native enzyme had broad pH stability, good thermostability and resistibility to various metal ions and chelating agents examined, while the recombinant enzyme had improved resistibility to SDS, which was stable in 0.2% (w/v) laundry detergent and thus showed great potential in detergents industry.

  10. Bayes classifiers for imbalanced traffic accidents datasets.

    PubMed

    Mujalli, Randa Oqab; López, Griselda; Garach, Laura

    2016-03-01

    Traffic accidents data sets are usually imbalanced, where the number of instances classified under the killed or severe injuries class (minority) is much lower than those classified under the slight injuries class (majority). This, however, supposes a challenging problem for classification algorithms and may cause obtaining a model that well cover the slight injuries instances whereas the killed or severe injuries instances are misclassified frequently. Based on traffic accidents data collected on urban and suburban roads in Jordan for three years (2009-2011); three different data balancing techniques were used: under-sampling which removes some instances of the majority class, oversampling which creates new instances of the minority class and a mix technique that combines both. In addition, different Bayes classifiers were compared for the different imbalanced and balanced data sets: Averaged One-Dependence Estimators, Weightily Average One-Dependence Estimators, and Bayesian networks in order to identify factors that affect the severity of an accident. The results indicated that using the balanced data sets, especially those created using oversampling techniques, with Bayesian networks improved classifying a traffic accident according to its severity and reduced the misclassification of killed and severe injuries instances. On the other hand, the following variables were found to contribute to the occurrence of a killed causality or a severe injury in a traffic accident: number of vehicles involved, accident pattern, number of directions, accident type, lighting, surface condition, and speed limit. This work, to the knowledge of the authors, is the first that aims at analyzing historical data records for traffic accidents occurring in Jordan and the first to apply balancing techniques to analyze injury severity of traffic accidents.

  11. Nordic rattle: the hoarse vocalization and the inflatable laryngeal air sac of reindeer (Rangifer tarandus).

    PubMed

    Frey, Roland; Gebler, Alban; Fritsch, Guido; Nygrén, Kaarlo; Weissengruber, Gerald E

    2007-02-01

    Laryngeal air sacs have evolved convergently in diverse mammalian lineages including insectivores, bats, rodents, pinnipeds, ungulates and primates, but their precise function has remained elusive. Among cervids, the vocal tract of reindeer has evolved an unpaired inflatable ventrorostral laryngeal air sac. This air sac is not present at birth but emerges during ontogenetic development. It protrudes from the laryngeal vestibulum via a short duct between the epiglottis and the thyroid cartilage. In the female the growth of the air sac stops at the age of 2-3 years, whereas in males it continues to grow up to the age of about 6 years, leading to a pronounced sexual dimorphism of the air sac. In adult females it is of moderate size (about 100 cm3), whereas in adult males it is large (3000-4000 cm3) and becomes asymmetric extending either to the left or to the right side of the neck. In both adult females and males the ventral air sac walls touch the integument. In the adult male the air sac is laterally covered by the mandibular portion of the sternocephalic muscle and the skin. Both sexes of reindeer have a double stylohyoid muscle and a thyroepiglottic muscle. Possibly these muscles assist in inflation of the air sac. Head-and-neck specimens were subjected to macroscopic anatomical dissection, computer tomographic analysis and skeletonization. In addition, isolated larynges were studied for comparison. Acoustic recordings were made during an autumn round-up of semi-domestic reindeer in Finland and in a small zoo herd. Male reindeer adopt a specific posture when emitting their serial hoarse rutting calls. Head and neck are kept low and the throat region is extended. In the ventral neck region, roughly corresponding to the position of the large air sac, there is a mane of longer hairs. Neck swelling and mane spreading during vocalization may act as an optical signal to other males and females. The air sac, as a side branch of the vocal tract, can be considered as an

  12. Nordic rattle: the hoarse vocalization and the inflatable laryngeal air sac of reindeer (Rangifer tarandus)

    PubMed Central

    Frey, Roland; Gebler, Alban; Fritsch, Guido; Nygrén, Kaarlo; Weissengruber, Gerald E

    2007-01-01

    Laryngeal air sacs have evolved convergently in diverse mammalian lineages including insectivores, bats, rodents, pinnipeds, ungulates and primates, but their precise function has remained elusive. Among cervids, the vocal tract of reindeer has evolved an unpaired inflatable ventrorostral laryngeal air sac. This air sac is not present at birth but emerges during ontogenetic development. It protrudes from the laryngeal vestibulum via a short duct between the epiglottis and the thyroid cartilage. In the female the growth of the air sac stops at the age of 2–3 years, whereas in males it continues to grow up to the age of about 6 years, leading to a pronounced sexual dimorphism of the air sac. In adult females it is of moderate size (about 100 cm3), whereas in adult males it is large (3000–4000 cm3) and becomes asymmetric extending either to the left or to the right side of the neck. In both adult females and males the ventral air sac walls touch the integument. In the adult male the air sac is laterally covered by the mandibular portion of the sternocephalic muscle and the skin. Both sexes of reindeer have a double stylohyoid muscle and a thyroepiglottic muscle. Possibly these muscles assist in inflation of the air sac. Head-and-neck specimens were subjected to macroscopic anatomical dissection, computer tomographic analysis and skeletonization. In addition, isolated larynges were studied for comparison. Acoustic recordings were made during an autumn round-up of semi-domestic reindeer in Finland and in a small zoo herd. Male reindeer adopt a specific posture when emitting their serial hoarse rutting calls. Head and neck are kept low and the throat region is extended. In the ventral neck region, roughly corresponding to the position of the large air sac, there is a mane of longer hairs. Neck swelling and mane spreading during vocalization may act as an optical signal to other males and females. The air sac, as a side branch of the vocal tract, can be considered as

  13. Conjunctival sac bacterial flora isolated prior to cataract surgery

    PubMed Central

    Suto, Chikako; Morinaga, Masahiro; Yagi, Tomoko; Tsuji, Chieko; Toshida, Hiroshi

    2012-01-01

    Objective To determine the trends of conjunctival sac bacterial flora isolated from patients prior to cataract surgery. Subjects and methods The study comprised 579 patients (579 eyes) who underwent cataract surgery. Specimens were collected by lightly rubbing the inferior palpebral conjunctival sac with a sterile cotton swab 2 weeks before surgery, and then cultured for isolation of bacteria and antimicrobial sensitivity testing. The bacterial isolates and percentage of drug-resistant isolates were compared among age groups and according to whether or not patients had diabetes mellitus, hyperlipidemia, dialysis therapy, oral steroid use, dry eye syndrome, or allergic conjunctivitis. Results The bacterial isolation rate was 39.2%. There were 191 strains of Gram-positive cocci, accounting for the majority of all isolates (67.0%), among which methicillin-sensitive coagulase-negative staphylococci was the most frequent (127 strains, 44.5%), followed by methicillin-resistant coagulase-negative staphylococci (37 strains, 12.7%). All 76 Gram-positive bacillary isolates (26.7%) were from the genus Corynebacterium. Among the 16 Gram-negative bacillary isolates (5.9%), the most frequent was Escherichia coli (1.0%). The bacterial isolation rate was higher in patients >60 years old, and was lower in patients with dry eye syndrome, patients under topical treatment for other ocular disorders, and patients with hyperlipidemia. There was no significant difference in bacterial isolation rate with respect to the presence/absence of diabetes mellitus, steroid therapy, dialysis, or a history of allergic conjunctivitis. Methicillin-resistant coagulase-negative staphylococci showed a significantly higher detection rate in diabetic patients than nondiabetic patients (20.3% versus 7.0%, P < 0.05). The percentage of all isolates resistant to levofloxacin, cefmenoxime, and tobramycin was 14.0%, 15.2%, and 17.9%, respectively, with no significant differences among these drugs. Conclusion

  14. The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

    PubMed Central

    Wang, Jinzhi; Chen, Juxing; Enns, Caroline A.; Mayinger, Peter

    2013-01-01

    The lipid phosphatase Sac1 cycles between endoplasmic reticulum and cisternal Golgi compartments. In proliferating mammalian cells, a canonical dilysine motif at the C-terminus of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER. Starvation triggers accumulation of Sac1 at the Golgi. The mechanism responsible for Golgi retention of Sac1 is unknown. Here we show that the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization. A minimal construct containing only TM1 and the adjacent flanking sequences is concentrated at the Golgi. Transplanting TM1 into transferrin receptor 2 (TfR2) induces Golgi accumulation of this normally plasma membrane and endosomal protein, indicating that TM1 is sufficient for Golgi localization. In addition, we determined that the N-terminal cytoplasmic domain of SAC1 also promotes Golgi localization, even when TM1 is mutated or absent. We conclude that the distribution of SAC1 within the Golgi is controlled via both passive membrane thickness-dependent partitioning of TM1 and a retention mechanism that requires the N-terminal cytoplasmic region. PMID:23936490

  15. The Sac1 Phosphoinositide Phosphatase Regulates Golgi Membrane Morphology and Mitotic Spindle Organization in Mammals

    PubMed Central

    Liu, Yang; Boukhelifa, Malika; Tribble, Emily; Morin-Kensicki, Elizabeth; Uetrecht, Andrea; Bear, James E.

    2008-01-01

    Phosphoinositides (PIPs) are ubiquitous regulators of signal transduction events in eukaryotic cells. PIPs are degraded by various enzymes, including PIP phosphatases. The integral membrane Sac1 phosphatases represent a major class of such enzymes. The central role of lipid phosphatases in regulating PIP homeostasis notwithstanding, the biological functions of Sac1-phosphatases remain poorly characterized. Herein, we demonstrate that functional ablation of the single murine Sac1 results in preimplantation lethality in the mouse and that Sac1 insufficiencies result in disorganization of mammalian Golgi membranes and mitotic defects characterized by multiple mechanically active spindles. Complementation experiments demonstrate mutant mammalian Sac1 proteins individually defective in either phosphoinositide phosphatase activity, or in recycling of the enzyme from the Golgi system back to the endoplasmic reticulum, are nonfunctional proteins in vivo. The data indicate Sac1 executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles and that both enzymatic activity and endoplasmic reticulum localization are important Sac1 functional properties. PMID:18480408

  16. The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals.

    PubMed

    Liu, Yang; Boukhelifa, Malika; Tribble, Emily; Morin-Kensicki, Elizabeth; Uetrecht, Andrea; Bear, James E; Bankaitis, Vytas A

    2008-07-01

    Phosphoinositides (PIPs) are ubiquitous regulators of signal transduction events in eukaryotic cells. PIPs are degraded by various enzymes, including PIP phosphatases. The integral membrane Sac1 phosphatases represent a major class of such enzymes. The central role of lipid phosphatases in regulating PIP homeostasis notwithstanding, the biological functions of Sac1-phosphatases remain poorly characterized. Herein, we demonstrate that functional ablation of the single murine Sac1 results in preimplantation lethality in the mouse and that Sac1 insufficiencies result in disorganization of mammalian Golgi membranes and mitotic defects characterized by multiple mechanically active spindles. Complementation experiments demonstrate mutant mammalian Sac1 proteins individually defective in either phosphoinositide phosphatase activity, or in recycling of the enzyme from the Golgi system back to the endoplasmic reticulum, are nonfunctional proteins in vivo. The data indicate Sac1 executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles and that both enzymatic activity and endoplasmic reticulum localization are important Sac1 functional properties.

  17. Persistence of airline accidents.

    PubMed

    Barros, Carlos Pestana; Faria, Joao Ricardo; Gil-Alana, Luis Alberiko

    2010-10-01

    This paper expands on air travel accident research by examining the relationship between air travel accidents and airline traffic or volume in the period from 1927-2006. The theoretical model is based on a representative airline company that aims to maximise its profits, and it utilises a fractional integration approach in order to determine whether there is a persistent pattern over time with respect to air accidents and air traffic. Furthermore, the paper analyses how airline accidents are related to traffic using a fractional cointegration approach. It finds that airline accidents are persistent and that a (non-stationary) fractional cointegration relationship exists between total airline accidents and airline passengers, airline miles and airline revenues, with shocks that affect the long-run equilibrium disappearing in the very long term. Moreover, this relation is negative, which might be due to the fact that air travel is becoming safer and there is greater competition in the airline industry. Policy implications are derived for countering accident events, based on competition and regulation.

  18. SAC phosphoinositide phosphatases at the tonoplast mediate vacuolar function in Arabidopsis

    PubMed Central

    Nováková, Petra; Hirsch, Sibylle; Feraru, Elena; Tejos, Ricardo; van Wijk, Ringo; Viaene, Tom; Heilmann, Mareike; Lerche, Jennifer; De Rycke, Riet; Feraru, Mugurel I.; Grones, Peter; Van Montagu, Marc; Heilmann, Ingo; Munnik, Teun; Friml, Jiří

    2014-01-01

    Phosphatidylinositol (PtdIns) is a structural phospholipid that can be phosphorylated into various lipid signaling molecules, designated polyphosphoinositides (PPIs). The reversible phosphorylation of PPIs on the 3, 4, or 5 position of inositol is performed by a set of organelle-specific kinases and phosphatases, and the characteristic head groups make these molecules ideal for regulating biological processes in time and space. In yeast and mammals, PtdIns3P and PtdIns(3,5)P2 play crucial roles in trafficking toward the lytic compartments, whereas the role in plants is not yet fully understood. Here we identified the role of a land plant-specific subgroup of PPI phosphatases, the suppressor of actin 2 (SAC2) to SAC5, during vacuolar trafficking and morphogenesis in Arabidopsis thaliana. SAC2–SAC5 localize to the tonoplast along with PtdIns3P, the presumable product of their activity. In SAC gain- and loss-of-function mutants, the levels of PtdIns monophosphates and bisphosphates were changed, with opposite effects on the morphology of storage and lytic vacuoles, and the trafficking toward the vacuoles was defective. Moreover, multiple sac knockout mutants had an increased number of smaller storage and lytic vacuoles, whereas extralarge vacuoles were observed in the overexpression lines, correlating with various growth and developmental defects. The fragmented vacuolar phenotype of sac mutants could be mimicked by treating wild-type seedlings with PtdIns(3,5)P2, corroborating that this PPI is important for vacuole morphology. Taken together, these results provide evidence that PPIs, together with their metabolic enzymes SAC2–SAC5, are crucial for vacuolar trafficking and for vacuolar morphology and function in plants. PMID:24550313

  19. The effect of pigeon yolk sac fluid on the growth behavior of calcium carbonate crystals.

    PubMed

    Song, Juan; Cheng, Haixia; Shen, Xinyu; Tong, Hua

    2015-03-01

    Previous experiments have proved that thermodynamically unstable calcium carbonate vaterite can exist for long periods in the yolk sac of a pigeon embryo. The aim of this article was to demonstrate the effect of in vitro mineralization of yolk sac fluid on calcium carbonate by direct precipitation. Experiments were conducted using pigeon yolk sac fluid and using lecithin extracted from pigeon yolk sac fluid as a control to investigate the regulating effects of the organic components in the embryo on the formation of the calcium carbonate precipitate. Multiple characterization methods were employed to study the various morphological patterns, sizes, crystal growth, and crystal phase transformations of the calcium carbonate precipitates as regulated by the yolk sac fluid extracted at different stages of incubation. The experimental results demonstrate that as the incubation proceeds towards the later stages, the composition and environmental features of the yolk sac fluid become more favorable for the formation of relatively unstable calcium carbonate phases with high energies of the vaterite state. The experiments conducted with extracted lecithin as the template for crystal growth yielded similar results. A large amount of organic molecules with polar functional groups carried by the yolk sac fluid have strong effects and can both initially induce the crystallization and regulate the aggregation of calcium carbonate. Furthermore, this regulation process is found to be closely related to the lecithin contained in yolk sac fluid. These observations confirm the changes in yolk sac fluid composition during incubation have significant effects on the production of vaterite, which implicates the calcium transport during embryo growth.

  20. Primary yolk sac tumor of the gluteus: a case report and literature review

    PubMed Central

    Li, Bo; Jiang, Qianqian; Zhang, Shitai; Zhou, Yang; Zhang, Qing-Fu; OuYang, Ling

    2016-01-01

    Yolk sac tumor (YST) is a common malignant primitive germ cell tumor that often exhibits differentiation into endodermal structures. They most commonly occur in childhood and adolescence and are rare after the age of 40 years. Derived from the yolk sac during the embryonic period, YSTs can occur in the gonads and germ cells because the tumor cells migrate from the yolk sac toward the gonads. Here, we present a rare case of primary gluteus YST in a 3-year-old girl. She received BEP chemotherapy (bleomycin + etoposide + cisplatin) after surgical resection. There was no evidence of recurrence 7 months after primary treatment. PMID:27536133

  1. Primary yolk sac tumor of the gluteus: a case report and literature review.

    PubMed

    Li, Bo; Jiang, Qianqian; Zhang, Shitai; Zhou, Yang; Zhang, Qing-Fu; OuYang, Ling

    2016-01-01

    Yolk sac tumor (YST) is a common malignant primitive germ cell tumor that often exhibits differentiation into endodermal structures. They most commonly occur in childhood and adolescence and are rare after the age of 40 years. Derived from the yolk sac during the embryonic period, YSTs can occur in the gonads and germ cells because the tumor cells migrate from the yolk sac toward the gonads. Here, we present a rare case of primary gluteus YST in a 3-year-old girl. She received BEP chemotherapy (bleomycin + etoposide + cisplatin) after surgical resection. There was no evidence of recurrence 7 months after primary treatment. PMID:27536133

  2. Surveillance Analysis Computer System (SACS): Software requirements specification (SRS). Revision 2

    SciTech Connect

    Glasscock, J.A.

    1995-03-08

    This document is the primary document establishing requirements for the Surveillance Analysis Computer System (SACS) database, an Impact Level 3Q system. SACS stores information on tank temperatures, surface levels, and interstitial liquid levels. This information is retrieved by the customer through a PC-based interface and is then available to a number of other software tools. The software requirements specification (SRS) describes the system requirements for the SACS Project, and follows the Standard Engineering Practices (WHC-CM-6-1), Software Practices (WHC-CM-3-10) and Quality Assurance (WHC-CM-4-2, QR 19.0) policies.

  3. Accident resistant transport container

    DOEpatents

    Anderson, J.A.; Cole, K.K.

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  4. Accident resistant transport container

    DOEpatents

    Andersen, John A.; Cole, James K.

    1980-01-01

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  5. Safety Is No Accident.

    ERIC Educational Resources Information Center

    Christiansen, Monty L.

    1985-01-01

    Liability suits involving accidents in park and recreation areas are expensive and intangible costs are incalculable. Risk management practices related to park planning, personnel, and administrative practices are discussed. (MT)

  6. Anthropotechnological analysis of industrial accidents in Brazil.

    PubMed Central

    Binder, M. C.; de Almeida, I. M.; Monteau, M.

    1999-01-01

    The Brazilian Ministry of Labour has been attempting to modify the norms used to analyse industrial accidents in the country. For this purpose, in 1994 it tried to make compulsory use of the causal tree approach to accident analysis, an approach developed in France during the 1970s, without having previously determined whether it is suitable for use under the industrial safety conditions that prevail in most Brazilian firms. In addition, opposition from Brazilian employers has blocked the proposed changes to the norms. The present study employed anthropotechnology to analyse experimental application of the causal tree method to work-related accidents in industrial firms in the region of Botucatu, São Paulo. Three work-related accidents were examined in three industrial firms representative of local, national and multinational companies. On the basis of the accidents analysed in this study, the rationale for the use of the causal tree method in Brazil can be summarized for each type of firm as follows: the method is redundant if there is a predominance of the type of risk whose elimination or neutralization requires adoption of conventional industrial safety measures (firm representative of local enterprises); the method is worth while if the company's specific technical risks have already largely been eliminated (firm representative of national enterprises); and the method is particularly appropriate if the firm has a good safety record and the causes of accidents are primarily related to industrial organization and management (multinational enterprise). PMID:10680249

  7. Histological and histochemical analyses of the cuttlebone sac of the golden cuttlefish Sepia esculenta

    NASA Astrophysics Data System (ADS)

    Zheng, Xiaodong; Xiao, Shu; Wang, Zhaoping; Wang, Rucai

    2007-10-01

    The secretion function of mantle is closely related to shell formation in some bivalves and gastropods. Up to now, few researches have been reported for cuttlebone formation in the class Cephalopoda. In this study, the structure and secretion function of cuttlebone sac of the golden cuttlefish Sepia esculenta was analyzed using the histological and histochemical methods. The results showed that high and columnar cells located in sac epithelium, and flat cells existed near the base membrane. A lot of fibroblasts were found in the lateral mantle collective tissue. Some mucus, mucopolysaccharide and alkaline phosphatase (ALP) were found in the sac. The ultrastructural characteristics of Quasi-connective-tissue-calcium cells (QCTCC) were observed using a transmission electron microscope (TEM). The relationship between cuttlebone sac secretion function and shell formation was discussed.

  8. Evidence for Avian Intrathoracic Air Sacs in a New Predatory Dinosaur from Argentina

    PubMed Central

    Sereno, Paul C.; Martinez, Ricardo N.; Wilson, Jeffrey A.; Varricchio, David J.; Alcober, Oscar A.; Larsson, Hans C. E.

    2008-01-01

    Background Living birds possess a unique heterogeneous pulmonary system composed of a rigid, dorsally-anchored lung and several compliant air sacs that operate as bellows, driving inspired air through the lung. Evidence from the fossil record for the origin and evolution of this system is extremely limited, because lungs do not fossilize and because the bellow-like air sacs in living birds only rarely penetrate (pneumatize) skeletal bone and thus leave a record of their presence. Methodology/Principal Findings We describe a new predatory dinosaur from Upper Cretaceous rocks in Argentina, Aerosteon riocoloradensis gen. et sp. nov., that exhibits extreme pneumatization of skeletal bone, including pneumatic hollowing of the furcula and ilium. In living birds, these two bones are pneumatized by diverticulae of air sacs (clavicular, abdominal) that are involved in pulmonary ventilation. We also describe several pneumatized gastralia (“stomach ribs”), which suggest that diverticulae of the air sac system were present in surface tissues of the thorax. Conclusions/Significance We present a four-phase model for the evolution of avian air sacs and costosternal-driven lung ventilation based on the known fossil record of theropod dinosaurs and osteological correlates in extant birds: (1) Phase I—Elaboration of paraxial cervical air sacs in basal theropods no later than the earliest Late Triassic. (2) Phase II—Differentiation of avian ventilatory air sacs, including both cranial (clavicular air sac) and caudal (abdominal air sac) divisions, in basal tetanurans during the Jurassic. A heterogeneous respiratory tract with compliant air sacs, in turn, suggests the presence of rigid, dorsally attached lungs with flow-through ventilation. (3) Phase III—Evolution of a primitive costosternal pump in maniraptoriform theropods before the close of the Jurassic. (4) Phase IV—Evolution of an advanced costosternal pump in maniraptoran theropods before the close of the

  9. Calculation of relative tube/tube support plate displacements in steam generators under accident condition loads using non-linear dynamic analysis methodologies

    SciTech Connect

    Smith, R.E.; Waisman, R.; Hu, M.H.; Frick, T.M.

    1995-12-01

    A non-linear analysis has been performed to determine relative motions between tubes and tube support plates (TSP) during a steam line break (SLB) event for steam generators. The SLB event results in blowdown of steam and water out of the steam generator. The fluid blowdown generates pressure drops across the TSPS, resulting in out-of-plane motion. The SLB induced pressure loads are calculated with a computer program that uses a drift-flux modeling of the two-phase flow. In order to determine the relative tube/TSP motions, a nonlinear dynamic time-history analysis is performed using a structural model that considers all of the significant component members relative to the tube support system. The dynamic response of the structure to the pressure loads is calculated using a special purpose computer program. This program links the various substructures at common degrees of freedom into a combined mass and stiffness matrix. The program accounts for structural non-linearities, including potential tube and TSP interaction at any given tube position. The program also accounts for structural damping as part of the dynamic response. Incorporating all of the above effects, the equations of motion are solved to give TSP displacements at the reduced set of DOF. Using the displacement results from the dynamic analysis, plate stresses are then calculated using the detailed component models. Displacements form the dynamic analysis are imposed as boundary conditions at the DOF locations, and the finite element program then solves for the overall distorted geometry. Calculations are also performed to assure that assumptions regarding elastic response of the various structural members and support points are valid.

  10. Application of biomarkers to assess the condition of European Marine Sites.

    PubMed

    Hagger, Josephine A; Galloway, Tamara S; Langston, William J; Jones, Malcolm B

    2009-07-01

    A series of European Marine Sites has been designated as Special Areas of Conservation (SAC) in England. The aim of this study was to develop a practical methodology to assess the condition of SACs by applying a suite of biomarkers. Biomarkers were applied to the blue mussel Mytilus edulis and the shore crab Carcinus maenas from the Fal and Helford SAC (Cornwall). Individual biomarkers provided useful diagnostic information on the activity of certain classes of contaminants and an integrated Biomarker Response Index (BRI) was used to achieve a more holistic understanding of the condition of the SAC. The BRI indicated that the general health of both organisms was impacted in the upper part of the SAC (Fal Estuary) which correlated well with known chemical hotspots and sources of contamination. The BRI allows a pragmatic way to prioritise SAC sites that may require further investigative studies. PMID:19359075

  11. Deposition of anal-sac secretions by captive wolves (Canis lupus)

    USGS Publications Warehouse

    Asa, C.S.; Peterson, E.K.; Seal, U.S.; Mech, L.D.

    1985-01-01

    Deposition of anal-sac secretions by captive wolves was investigated by a labelling technique using protein-bound iodine125 and food dye. Wolves deposited secretions on some but not all scats. Adult males, especially the alpha male, deposited anal-sac secretions more frequently while defecating than did females or juveniles. Secretions sometimes also were deposited independently of defecation, suggesting a dual role in communication by these substances.

  12. HTGR severe accident sequence analysis

    SciTech Connect

    Harrington, R.M.; Ball, S.J.; Kornegay, F.C.

    1982-01-01

    Thermal-hydraulic, fission product transport, and atmospheric dispersion calculations are presented for hypothetical severe accident release paths at the Fort St. Vrain (FSV) high temperature gas cooled reactor (HTGR). Off-site radiation exposures are calculated for assumed release of 100% of the 24 hour post-shutdown core xenon and krypton inventory and 5.5% of the iodine inventory. The results show conditions under which dose avoidance measures would be desirable and demonstrate the importance of specific release characteristics such as effective release height. 7 tables.

  13. Sac1--Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus

    SciTech Connect

    Cai, Yiying; Deng, Yongqiang; Horenkamp, Florian; Reinisch, Karin M.; Burd, Christopher G.

    2014-08-25

    Sac1 is a phosphoinositide phosphatase of the endoplasmic reticulum and Golgi apparatus that controls organelle membrane composition principally via regulation of phosphatidylinositol 4-phosphate signaling. We present a characterization of the structure of the N-terminal portion of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologue of human GOLPH3. The interface involves the N-terminal subdomain of the Sac1 homology domain, within which mutations in the related Sac3/Fig4 phosphatase have been linked to Charcot–Marie–Tooth disorder CMT4J and amyotrophic lateral sclerosis. Disruption of the Sac1–Vps74 interface results in a broader distribution of phosphatidylinositol 4-phosphate within the Golgi apparatus and failure to maintain residence of a medial Golgi mannosyltransferase. The analysis prompts a revision of the membrane-docking mechanism for GOLPH3 family proteins and reveals how an effector of phosphoinositide signaling serves a dual function in signal termination.

  14. Accident progression event tree analysis for postulated severe accidents at N Reactor

    SciTech Connect

    Wyss, G.D.; Camp, A.L.; Miller, L.A.; Dingman, S.E.; Kunsman, D.M. ); Medford, G.T. )

    1990-06-01

    A Level II/III probabilistic risk assessment (PRA) has been performed for N Reactor, a Department of Energy (DOE) production reactor located on the Hanford reservation in Washington. The accident progression analysis documented in this report determines how core damage accidents identified in the Level I PRA progress from fuel damage to confinement response and potential releases the environment. The objectives of the study are to generate accident progression data for the Level II/III PRA source term model and to identify changes that could improve plant response under accident conditions. The scope of the analysis is comprehensive, excluding only sabotage and operator errors of commission. State-of-the-art methodology is employed based largely on the methods developed by Sandia for the US Nuclear Regulatory Commission in support of the NUREG-1150 study. The accident progression model allows complex interactions and dependencies between systems to be explicitly considered. Latin Hypecube sampling was used to assess the phenomenological and systemic uncertainties associated with the primary and confinement system responses to the core damage accident. The results of the analysis show that the N Reactor confinement concept provides significant radiological protection for most of the accident progression pathways studied.

  15. 29 CFR 1915.91 - Accident prevention signs and tags.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Working Conditions § 1915.91 Accident prevention signs and tags. The requirements applicable to shipyard employment under this section are identical to the requirements set forth at 29 CFR 1910.145 of this chapter. ... 29 Labor 7 2012-07-01 2012-07-01 false Accident prevention signs and tags. 1915.91 Section...

  16. 29 CFR 1915.91 - Accident prevention signs and tags.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Working Conditions § 1915.91 Accident prevention signs and tags. The requirements applicable to shipyard employment under this section are identical to the requirements set forth at 29 CFR 1910.145 of this chapter. ... 29 Labor 7 2013-07-01 2013-07-01 false Accident prevention signs and tags. 1915.91 Section...

  17. 29 CFR 1915.91 - Accident prevention signs and tags.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Working Conditions § 1915.91 Accident prevention signs and tags. The requirements applicable to shipyard employment under this section are identical to the requirements set forth at 29 CFR 1910.145 of this chapter. ... 29 Labor 7 2014-07-01 2014-07-01 false Accident prevention signs and tags. 1915.91 Section...

  18. Injuries are not accidents

    PubMed Central

    Gutiérrez, María Isabel

    2014-01-01

    Injuries are the result of an acute exposure to exhort of energy or a consequence of a deficiency in a vital element that exceeds physiological thresholds resulting threatens life. They are classified as intentional or unintentional. Injuries are considered a global health issue because they cause more than 5 million deaths per year worldwide and they are an important contributor to the burden of disease, especially affecting people of low socioeconomic status in low- and middle-income countries. A common misconception exists where injuries are thought to be the same as accidents; however, accidents are largely used as chance events, without taken in consideration that all these are preventable. This review discusses injuries and accidents in the context of road traffic and emphasizes injuries as preventable events. An understanding of the essence of injuries enables the standardization of terminology in public use and facilitates the development of a culture of prevention among all of us. PMID:25386040

  19. Accident prevention manual

    SciTech Connect

    Not Available

    1998-05-01

    Among the many common needs and goals are the safety and well-being of families, ourselves, fellow employees, and the continuing success of this organization. To these ends--minimizing human suffering and economic waste--the Bonneville Power Administration (BPA) Accident Prevention Program and this Accident Prevention Manual (APM) are dedicated. The BPA Accident Prevention Program is revised as necessary to ensure compliance with relevant Federal safety and health standards. The mandatory rules herein express minimum requirements for dealing with the principal hazards inherent in daily work activities. These and other written requirements, which neither can nor should provide complete coverage of all work situations, must be continually reinforced through the sound and mature safety judgments of all workers on each assigned task. In the event of conflicting judgments, the more conservative interpretation shall prevail pending review and resolution by management.

  20. A case study of electrostatic accidents in the process of oil-gas storage and transportation

    NASA Astrophysics Data System (ADS)

    Hu, Yuqin; Wang, Diansheng; Liu, Jinyu; Gao, Jianshen

    2013-03-01

    Ninety nine electrostatic accidents were reviewed, based on information collected from published literature. All the accidents over the last 30 years occurred during the process of oil-gas storage and transportation. Statistical analysis of these accidents was performed based on the type of complex conditions where accidents occurred, type of tanks and contents, and type of accidents. It is shown that about 85% of the accidents occurred in tank farms, gas stations or petroleum refineries, and 96% of the accidents included fire or explosion. The fishbone diagram was used to summarize the effects and the causes of the effects. The results show that three major reasons were responsible for accidents, including improper operation during loading and unloading oil, poor grounding and static electricity on human bodies, which accounted for 29%, 24% and 13% of the accidents, respectively. Safety actions are suggested to help operating engineers to handle similar situations in the future.

  1. Instrumentation availability during severe accidents for a boiling water reactor with a Mark I containment

    SciTech Connect

    Arcieri, W.C.; Hanson, D.J. )

    1992-02-01

    In support of the US Nuclear Regulatory Commission Accident Management Research Program, the availability of instruments to supply accident management information during a broad range of severe accidents is evaluated for a Boiling Water Reactor with a Mark I containment. Results from this evaluation include: (1) the identification of plant conditions that would impact instrument performance and information needs during severe accidents; (2) the definition of envelopes of parameters that would be important in assessing the performance of plant instrumentation for a broad range of severe accident sequences; and (3) assessment of the availability of plant instrumentation during severe accidents.

  2. The Fukushima radiation accident: consequences for radiation accident medical management.

    PubMed

    Meineke, Viktor; Dörr, Harald

    2012-08-01

    The March 2011 radiation accident in Fukushima, Japan, is a textbook example of a radiation accident of global significance. In view of the global dimensions of the accident, it is important to consider the lessons learned. In this context, emphasis must be placed on consequences for planning appropriate medical management for radiation accidents including, for example, estimates of necessary human and material resources. The specific characteristics of the radiation accident in Fukushima are thematically divided into five groups: the exceptional environmental influences on the Fukushima radiation accident, particular circumstances of the accident, differences in risk perception, changed psychosocial factors in the age of the Internet and globalization, and the ignorance of the effects of ionizing radiation both among the general public and health care professionals. Conclusions like the need for reviewing international communication, interfacing, and interface definitions will be drawn from the Fukushima radiation accident. PMID:22951483

  3. The Fukushima radiation accident: consequences for radiation accident medical management.

    PubMed

    Meineke, Viktor; Dörr, Harald

    2012-08-01

    The March 2011 radiation accident in Fukushima, Japan, is a textbook example of a radiation accident of global significance. In view of the global dimensions of the accident, it is important to consider the lessons learned. In this context, emphasis must be placed on consequences for planning appropriate medical management for radiation accidents including, for example, estimates of necessary human and material resources. The specific characteristics of the radiation accident in Fukushima are thematically divided into five groups: the exceptional environmental influences on the Fukushima radiation accident, particular circumstances of the accident, differences in risk perception, changed psychosocial factors in the age of the Internet and globalization, and the ignorance of the effects of ionizing radiation both among the general public and health care professionals. Conclusions like the need for reviewing international communication, interfacing, and interface definitions will be drawn from the Fukushima radiation accident.

  4. Saccharinato complexes of Ce(V) with 2-hydroxypyridine: Synthesis, spectroscopic and thermal characteristics of [Ce(sac) 2(SO 4)(H 2O) 4] and [Ce(sac) 2(SO 4)(PyOH) 2

    NASA Astrophysics Data System (ADS)

    Gaballa, Akmal S.; Teleb, Said M.; Müller, Thomas

    2008-10-01

    The synthesis of Ce(IV) complexes [Ce(sac) 2(SO 4)(H 2O) 4] ( 1) and [Ce(sac) 2 (SO 4)(PyOH) 2] ( 2) (sac = saccharinate, PyOH = 2-hydroxypyridine) starting with sodium saccharinate is described. Their vibrational and nuclear magnetic resonance ( 1H, 13C) spectra as well as their thermal mode of degradation were investigated. The data indicate that sac in complex 1 behaves as a monodentate ligand through the nitrogen atoms. Saccharinato ligand in complex 2 shows different mode of coordination, where it behaves as tridentate and binds Ce(IV) through its carbonylic oxygen, nitrogen and sulphonylic oxygen atoms. The most probable structure in complex 2 is that, units of [Ce(sac) 2(SO 4)(PyOH) 2] are linked by bridges of the O- of sac sulphonyl leading to polymeric chains.

  5. Saccharinato complexes of Ce(V) with 2-hydroxypyridine: synthesis, spectroscopic and thermal characteristics of [Ce(sac)2(SO4)(H2O)4] and [Ce(sac)2(SO4)(PyOH)2].

    PubMed

    Gaballa, Akmal S; Teleb, Said M; Müller, Thomas

    2008-10-01

    The synthesis of Ce(IV) complexes [Ce(sac)2(SO4)(H2O)4] (1) and [Ce(sac)2 (SO4)(PyOH)2] (2) (sac=saccharinate, PyOH=2-hydroxypyridine) starting with sodium saccharinate is described. Their vibrational and nuclear magnetic resonance (1H, 13C) spectra as well as their thermal mode of degradation were investigated. The data indicate that sac in complex 1 behaves as a monodentate ligand through the nitrogen atoms. Saccharinato ligand in complex 2 shows different mode of coordination, where it behaves as tridentate and binds Ce(IV) through its carbonylic oxygen, nitrogen and sulphonylic oxygen atoms. The most probable structure in complex 2 is that, units of [Ce(sac)2(SO4)(PyOH)2] are linked by bridges of the O- of sac sulphonyl leading to polymeric chains. PMID:18077205

  6. Accident tolerant fuels for LWRs: A perspective

    NASA Astrophysics Data System (ADS)

    Zinkle, S. J.; Terrani, K. A.; Gehin, J. C.; Ott, L. J.; Snead, L. L.

    2014-05-01

    The motivation for exploring the potential development of accident tolerant fuels in light water reactors to replace existing Zr alloy clad monolithic (U, Pu) oxide fuel is outlined. The evaluation includes a brief review of core degradation processes under design-basis and beyond-design-basis transient conditions. Three general strategies for accident tolerant fuels are being explored: modification of current state-of-the-art zirconium alloy cladding to further improve oxidation resistance (including use of coatings), replacement of Zr alloy cladding with an alternative oxidation-resistant high-performance cladding, and replacement of the monolithic ceramic oxide fuel with alternative fuel forms.

  7. Behavior of road accidents: Structural time series approach

    NASA Astrophysics Data System (ADS)

    Junus, Noor Wahida Md; Ismail, Mohd Tahir; Arsad, Zainudin

    2014-12-01

    Road accidents become a major issue in contributing to the increasing number of deaths. Few researchers suggest that road accidents occur due to road structure and road condition. The road structure and condition may differ according to the area and volume of traffic of the location. Therefore, this paper attempts to look up the behavior of the road accidents in four main regions in Peninsular Malaysia by employing a structural time series (STS) approach. STS offers the possibility of modelling the unobserved component such as trends and seasonal component and it is allowed to vary over time. The results found that the number of road accidents is described by a different model. Perhaps, the results imply that the government, especially a policy maker should consider to implement a different approach in ways to overcome the increasing number of road accidents.

  8. Development of Database for Accident Analysis in Indian Mines

    NASA Astrophysics Data System (ADS)

    Tripathy, Debi Prasad; Guru Raghavendra Reddy, K.

    2015-08-01

    Mining is a hazardous industry and high accident rates associated with underground mining is a cause of deep concern. Technological developments notwithstanding, rate of fatal accidents and reportable incidents have not shown corresponding levels of decline. This paper argues that adoption of appropriate safety standards by both mine management and the government may result in appreciable reduction in accident frequency. This can be achieved by using the technology in improving the working conditions, sensitising workers and managers about causes and prevention of accidents. Inputs required for a detailed analysis of an accident include information on location, time, type, cost of accident, victim, nature of injury, personal and environmental factors etc. Such information can be generated from data available in the standard coded accident report form. This paper presents a web based application for accident analysis in Indian mines during 2001-2013. An accident database (SafeStat) prototype based on Intranet of the TCP/IP agreement, as developed by the authors, is also discussed.

  9. Enhanced Accident Tolerant LWR Fuels: Metrics Development

    SciTech Connect

    Shannon Bragg-Sitton; Lori Braase; Rose Montgomery; Chris Stanek; Robert Montgomery; Lance Snead; Larry Ott; Mike Billone

    2013-09-01

    The Department of Energy (DOE) Fuel Cycle Research and Development (FCRD) Advanced Fuels Campaign (AFC) is conducting research and development on enhanced Accident Tolerant Fuels (ATF) for light water reactors (LWRs). This mission emphasizes the development of novel fuel and cladding concepts to replace the current zirconium alloy-uranium dioxide (UO2) fuel system. The overall mission of the ATF research is to develop advanced fuels/cladding with improved performance, reliability and safety characteristics during normal operations and accident conditions, while minimizing waste generation. The initial effort will focus on implementation in operating reactors or reactors with design certifications. To initiate the development of quantitative metrics for ATR, a LWR Enhanced Accident Tolerant Fuels Metrics Development Workshop was held in October 2012 in Germantown, MD. This paper summarizes the outcome of that workshop and the current status of metrics development for LWR ATF.

  10. Occupational accidents aboard merchant ships

    PubMed Central

    Hansen, H; Nielsen, D; Frydenberg, M

    2002-01-01

    Objectives: To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. Methods: The study is a historical follow up on occupational accidents among crew aboard Danish merchant ships in the period 1993–7. Data were extracted from the Danish Maritime Authority and insurance data. Exact data on time at risk were available. Results: A total of 1993 accidents were identified during a total of 31 140 years at sea. Among these, 209 accidents resulted in permanent disability of 5% or more, and 27 were fatal. The mean risk of having an occupational accident was 6.4/100 years at sea and the risk of an accident causing a permanent disability of 5% or more was 0.67/100 years aboard. Relative risks for notified accidents and accidents causing permanent disability of 5% or more were calculated in a multivariate analysis including ship type, occupation, age, time on board, change of ship since last employment period, and nationality. Foreigners had a considerably lower recorded rate of accidents than Danish citizens. Age was a major risk factor for accidents causing permanent disability. Change of ship and the first period aboard a particular ship were identified as risk factors. Walking from one place to another aboard the ship caused serious accidents. The most serious accidents happened on deck. Conclusions: It was possible to clearly identify work situations and specific risk factors for accidents aboard merchant ships. Most accidents happened while performing daily routine duties. Preventive measures should focus on workplace instructions for all important functions aboard and also on the prevention of accidents caused by walking around aboard the ship. PMID:11850550

  11. In Vivo and Cadaver Studies of the Canalicular/Lacrimal Sac Mucosal Folds

    PubMed Central

    You, Yongsheng; Cao, Jing; Zhang, Xiaogang; Wu, Wencan; Xiao, Tianlin

    2016-01-01

    Purpose. The study aimed to investigate canalicular/lacrimal sac mucosal folds (CLS-MFs) in vivo and in cadavers in order to explore their functional roles in the lacrimal drainage system. Method. The observations of CLS-MFs in vivo were performed on 16 patients with chronic dacryocystitis after undergoing an endonasal endoscopic dacryocystorhinostomy (EE-DCR). The lacrimal sacs and common canaliculi of 19 adult cadavers were dissected. The opening/closing of an orifice and mucosal fold was recorded. All of the specimens were subjected to a histological examination. Results. The upper and lower lacrimal canaliculi in all of the samples united to form a common canaliculus that opened to the lacrimal sac. CLS-MFs were observed in 10 of the 16 patients (62.5%) and 9 of the 19 cadavers (47.4%). The orifices or mucosal folds could be opened or closed when related muscles contracted or relaxed. Histological sections showed a mucosal fold at one side of an orifice. Conclusion. Common canaliculus is the most common type that the canaliculus opens to lacrimal sac. CLS-MFs exist in a certain ratio that can be opened/closed with the movement of the orifices. They may be involved in the drainage of tears or the pathogenesis of acute dacryocystitis or lacrimal sac mucocele. PMID:27242921

  12. Rectal sac distention is induced by 20-hydroxyecdysone in the pupa of Bombyx mori.

    PubMed

    Suzuki, Takumi; Sakurai, Sho; Iwami, Masafumi

    2009-03-01

    Holometabolous insects do not excrete but store metabolic wastes during the pupal period. The waste is called meconium and is purged after adult emergence. Although the contents of meconium are well-studied, the developmental and physiological regulation of meconium accumulation is poorly understood. In Bombyx mori, meconium is accumulated in the rectal sac; thereby, the rectal sac distends at the late pupal stage. Here, we show that rectal sac distention occurs between 4 and 5 days after pupation. The distention is halted by brain-removal just after larval-pupal ecdysis but not by brain-removal 1 day after pupation. In the pupae, brain-removal just after ecdysis kept the hemolymph ecdysteroid titer low during early and mid-pupal stages. An injection of 20-hydroxyecdysone (20E) evoked the distention that was halted by brain-removal in a dose-dependent manner. Therefore, brain-removal caused the lack of ecdysteroid, and rectal sac distention did not appear in the brain-removed pupae because of the lack of ecdysteroid. We conclude that rectal sac distention is one of the developmental events regulated by 20E during the pupal period in B. mori.

  13. Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy.

    PubMed

    Maharjan, Sony; Lee, Sujin; Agrawal, Vijayendra; Choi, Hyun-Jung; Maeng, Yong-Sun; Kim, Kyeojin; Kim, Nam-Jung; Suh, Young-Ger; Kwon, Young-Guen

    2011-04-25

    Endothelium integrity is important for the normal functioning of vessels, the disruption of which can lead to disease. The blood-retinal barrier required for normal retinal function is compromised in diabetic retinopathy, causing retinal vascular leakage. Previously, we demonstrated the ability of Sac-0601[((2R,3S)-3-acetoxy-6-((3S,10R,13R,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)-3,6-dihydro-2H-pyran-2-yl)methyl acetate], a pseudo-sugar derivative of cholesterol, to increase survival of retinal endothelial cells. In the present study, we evaluated the ability of Sac-0601 to prevent retinal vascular leakages in vitro and in vivo. Sac-0601 treatment blocked VEGF-induced formation of actin stress fibers and stabilized the cortical actin ring in retinal endothelial cells. It also inhibited degradation of occludin, an important tight junction protein, and blocked VEGF-induced disruption of its linear pattern at the cell border. The [(14)C] sucrose permeability assay demonstrated that Sac-0601 was able to prevent VEGF-induced retinal endothelial permeability. The compound inhibited the vascular leakage in retina of mice intravitreally injected with VEGF. And it also significantly reduced the leakage in retina of diabetic retinopathy mice model. Taken together, our findings suggest the potential therapeutic usefulness of Sac-0601 for retinal vascular permeability diseases.

  14. "Gestation sac" volumes as determined by sonar in the first trimester of pregnancy.

    PubMed

    Robinson, H P

    1975-02-01

    Sonar estimates of "gestation sac" volumes in the first trimester of pregnancy were made from a series of 319 measurements; the volumes estimated included the amniotic fluid, the extraembryonic coelom and the fetus. The technique employed involved the use of parallel section scans taken in series from one end of the gestation sac to the other, followed by planimetric measurements of the sac areas so produced. The potential errors which may be incurred in these measurements are discussed, and it is considered that the technique carries an overall possible error in the order of plus or minus 10 per cent. Growth curves produced from the measurements in this series show that the sac increases in volume from a mean of 1 ml. at 6 weeks to a mean of 100 ml. at 13 weeks, initially in an exponential fashion but latterly in a more linear manner. The mean values of the sonar gestation sac fluid volumes (after subtraction of the estimated fetal volume) in the 10 to 13 week range, show good correlation with those amniotic fluid values reported in the literature where direct measurements were made at the time of hysterotomy. As a method of assessing the maturity of a pregnancy this technique is of lesser value than the sonar measurement of fetal crown-rump length because of the relatively wider scatter of results. It has, however, found a useful place in clinical practice in the early sonar diagnosis of blighted ova or anembryonic pregnancies.

  15. A status report on the development of SAC2000: A new seismic analysis code

    SciTech Connect

    Goldstein, P.; Minner, L.

    1995-08-01

    We are developing a new Seismic Analysis Code (SAC2000) that will meet the research needs of the seismic research and treaty monitoring communities. Our first step in this development was to rewrite the original Seismic Analysis Code (SAC) -- a Fortran code that was approximately 140,000 lines long -- in the C programming language. This rewrite has resulted in a much more robust code that is faster, more efficient, and more portable than the original. We have implemented important processing capabilities such as convolution and binary monograms, and we have significantly enhanced several previously existing capabilities. For example, the spectrogram command now produces a correctly registered plot of the input time series and a color image of the output spectrogram. We have also added an image plotting capability with access to 17 predefined color tables or custom color tables. A rewritten version of the readcss command can now be used to access any of the documented css.3.0 database data formats, a capability that is particularly important to the Air Force Technical Applications Center (AFTAC) and the monitoring community. A much less visible, but extremely important contribution is the correction of numerous inconsistencies and errors that have evolved because of piecemeal development and limited maintenance since SAC was first written. We have also incorporated on-line documentation and have made SAC documentation available on the Internet via the world-wide-web at http://www-ep/tvp/sac.html.

  16. Developmental expression of otoconin-22 in the bullfrog endolymphatic sac and inner ear.

    PubMed

    Yaoi, Yuichi; Onda, Tomoaki; Hidaka, Yoshie; Yajima, Shinya; Suzuki, Masakazu; Tanaka, Shigeyasu

    2004-05-01

    In amphibians, calcium carbonate crystals are present in the endolymphatic sac and the inner ear. The formation of these crystals is considered to be facilitated by a protein called otoconin-22. We examined the spatial and temporal expression of otoconin-22 during the development of the bullfrog (Rana catesbeiana) using RT-PCR, in situ hybridization (ISH), and immunofluorescence techniques. By RT-PCR, otoconin-22 mRNA was first detected in embryos at Shumway stage 20, and this expression pattern continues in late stages. The first otoconin-22 mRNA-positive reaction was detected in stage 22 embryos in the placode of the endolymphatic sac. Otoconin-22 protein was observed in the epithelial cells of the endolymphatic sac at stage 24. On the other hand, a whole-mount ISH technique showed the first expression of otoconin-22 mRNA in the inner ear, in addition to the endolymphatic sac, at the mid-phase of Shumway stage 25. We discuss the role of otoconin-22 in the formation of calcium carbonate crystals in the endolymphatic sac and inner ear. PMID:15100243

  17. System response of a DOE Defense Program package in a transportation accident environment

    SciTech Connect

    Chen, T.F.; Hovingh, J.; Kimura, C.Y.

    1992-10-15

    The system response in a transportation accident environment is an element to be considered in an overall Transportation System Risk Assessment (TSRA) framework. The system response analysis uses the accident conditions and the subsequent accident progression analysis to develop the accident source term, which in turn, is used in the consequence analysis. This paper proposes a methodology for the preparation of the system response aspect of the TSRA.

  18. User's guide to SAC, a computer program for computing discharge by slope-area method

    USGS Publications Warehouse

    Fulford, Janice M.

    1994-01-01

    This user's guide contains information on using the slope-area program, SAC. SAC can be used to compute peak flood discharges from measurements of high-water marks along a stream reach. The Slope-area method used by the program is the U.S. Geological Survey (USGS) procedure presented in Techniques of Water Resources Investigations of the U.S. Geological Survey, beok 3, chapter A2, "Measurement of Peak Discharge by the Slope-Area Method." The program uses input files that have formats compatible with those used by the water-surface profile program (WSPRO) described in the Federal Highways Administration publication FHWA-IP-89-027. The guide briefly describes the slope-area method documents the input requirements and the output produced, and demonstrates use of SAC.

  19. Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography.

    PubMed

    Xu, Liang; Chen, Rongchang; Du, Guohao; Yang, Yiming; Wang, Feixiang; Deng, Biao; Xie, Honglan; Xiao, Tiqiao

    2016-01-01

    Air sacs are thought to be the bellows for insect respiration. However, their exact mechanism of action as a bellows remains unclear. A direct way to investigate this problem is in vivo observation of the changes in their three-dimensional structures. Therefore, four-dimensional X-ray phase contrast microtomography is employed to solve this puzzle. Quantitative analysis of three-dimensional image series reveals that the compression of the air sac during respiration in bell crickets exhibits obvious anisotropic characteristics both longitudinally and transversely. Volumetric changes of the tracheal trunks in the prothorax further strengthen the evidence of this finding. As a result, we conclude that the shrinkage and expansion of the insect air sac is anisotropic, contrary to the hypothesis of isotropy, thereby providing new knowledge for further research on the insect respiratory system. PMID:27580585

  20. [Chemotherapy of yolk sac tumor heterotransplanted to nude mice (author's transl)].

    PubMed

    Sawada, M; Hayakawa, K; Matsui, Y; Nishiura, H; Okudaira, Y

    1980-10-01

    Chemotherapy of yolk sac tumor heterotransplanted to nude mice was studied. 1. Yolk sac tumor of the ovary taken from a 38-year -old woman was transplanted to BALB/c female nude mice. The transplantable tumor cells produce a solid tumor, designated as YST-1 tumor. The YST-1 tumor cells preserve the histological appearance of a human yolk sac tumor and produce x-fetoprotein. The tumors on passage 8 were used for experimental chemotherapy. 2. Anticancer drugs clinically known to be effective for ovarian cancer, such as Adriamycin, Carbazilquinone, 5-Fluorouracil, Cyclophosphamide, Mitomycin C, Chromomycin A3, Vinblastine and Bleomycin were administered intraperitoneally to tumor-bearing nude mice. Tumor size was measured two or three times a week during the course of experiments. Therapeutic effects were evaluated by tumor size and relative tumor size before and after experiments. Among these drugs, Vinblastine and Bleomycin combination showed the significant effect arresting the growth of YST-1 tumor.

  1. A New Technique for Reduction the Phase Induced Intensity Noise in SAC-OCDMA Systems

    NASA Astrophysics Data System (ADS)

    Abd, Thanaa Hussein; Aljunid, Syed Alwee; Fadhil, Hilal Adnan

    2011-12-01

    A new code for reduction the phase induced intensity noise has been presented. The new code is proposed for Spectral Amplitude-Coding Optical Code Division Multiple Accesses (SAC-OCDMA). This new code family we call it Dynamic Cyclic Shift (DCS) code. The DCS code reduced the effect of Multi Access Interference (MAI) due to it is the property of variable cross correlation. We find that the performance of the DCS code is a batter than other SAC-OCDMA codes such as; Random Diagonal (RD) code, Modified Quadratic Congruence (MQC) code and Modified Frequency Hopping (MFH) code. Through the mathematical calculation and simulation analysis, for the bit-error rate of DCS code is significantly better than other SAC-OCDMA codes, the effect of Phase Induced Intensity Noise is reduced. In addition, proofof-principle simulations of 10 Gb/s for 20 km have been successfully demonstrated and achieved low BER compared to the other codes.

  2. Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography

    NASA Astrophysics Data System (ADS)

    Xu, Liang; Chen, Rongchang; Du, Guohao; Yang, Yiming; Wang, Feixiang; Deng, Biao; Xie, Honglan; Xiao, Tiqiao

    2016-09-01

    Air sacs are thought to be the bellows for insect respiration. However, their exact mechanism of action as a bellows remains unclear. A direct way to investigate this problem is in vivo observation of the changes in their three-dimensional structures. Therefore, four-dimensional X-ray phase contrast microtomography is employed to solve this puzzle. Quantitative analysis of three-dimensional image series reveals that the compression of the air sac during respiration in bell crickets exhibits obvious anisotropic characteristics both longitudinally and transversely. Volumetric changes of the tracheal trunks in the prothorax further strengthen the evidence of this finding. As a result, we conclude that the shrinkage and expansion of the insect air sac is anisotropic, contrary to the hypothesis of isotropy, thereby providing new knowledge for further research on the insect respiratory system.

  3. Amniote yolk sacs: diversity in reptiles and a hypothesis on their origin.

    PubMed

    Elinson, Richard P; Stewart, James R; Bonneau, Laurie J; Blackburn, Daniel G

    2014-01-01

    Oviparous amniotes produce a large yolky egg that gives rise to a free-living hatchling. Structural characteristics and functional attributes of the egg are best known for birds, which have a large mass of fluid yolk surrounded by an extraembryonic yolk sac. Yolk nutrients are delivered to the embryo via the vascular yolk sac. This developmental pattern and nutrient transport mechanism is thought to be representative of all other lineages of amniotes. Recent discovery of a snake with cellularized yolk organized around a meshwork of blood vessels reveals an additional pattern for yolk mobilization, which may also occur in other squamate reptiles (lizards and snakes). This complex yolk sac raises interesting questions about developmental mechanisms and suggests a possible model for the transition between the egg of anamniotes and that of amniotes.

  4. Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography

    PubMed Central

    Xu, Liang; Chen, Rongchang; Du, Guohao; Yang, Yiming; Wang, Feixiang; Deng, Biao; Xie, Honglan; Xiao, Tiqiao

    2016-01-01

    Air sacs are thought to be the bellows for insect respiration. However, their exact mechanism of action as a bellows remains unclear. A direct way to investigate this problem is in vivo observation of the changes in their three-dimensional structures. Therefore, four-dimensional X-ray phase contrast microtomography is employed to solve this puzzle. Quantitative analysis of three-dimensional image series reveals that the compression of the air sac during respiration in bell crickets exhibits obvious anisotropic characteristics both longitudinally and transversely. Volumetric changes of the tracheal trunks in the prothorax further strengthen the evidence of this finding. As a result, we conclude that the shrinkage and expansion of the insect air sac is anisotropic, contrary to the hypothesis of isotropy, thereby providing new knowledge for further research on the insect respiratory system. PMID:27580585

  5. Applying STAMP in Accident Analysis

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy; Daouk, Mirna; Dulac, Nicolas; Marais, Karen

    2003-01-01

    Accident models play a critical role in accident investigation and analysis. Most traditional models are based on an underlying chain of events. These models, however, have serious limitations when used for complex, socio-technical systems. Previously, Leveson proposed a new accident model (STAMP) based on system theory. In STAMP, the basic concept is not an event but a constraint. This paper shows how STAMP can be applied to accident analysis using three different views or models of the accident process and proposes a notation for describing this process.

  6. Design and Implementation of a Fuzzy Accident Detector

    NASA Astrophysics Data System (ADS)

    Jafari, Shahram; Arabnejad, Mohammad; Rashidi Moakhar, Ali

    A fuzzy accident detector has been proposed in this paper. The implemented controller ensures a reliable margin for the speed of a car. This is done by carefully observing the skills of the driver in controlling the automobile during a critical condition. Since x- and y- accelerations of the automobile change sharply during an accident, such conditions can be detected. The system also updates the speed limits in different locations on the road.

  7. Tractor accidents in Swedish traffic.

    PubMed

    Pinzke, Stefan; Nilsson, Kerstin; Lundqvist, Peter

    2012-01-01

    The objective of this study is to reach a better understanding of accidents on Swedish roads involving tractors and to suggest ways of preventing them. In an earlier study we analyzed police-reported fatal accidents and accidents that led to physical injuries from 1992 to 2005. During each year of this period, tractors were involved in 128 traffic accidents on average, an average of 7 people were killed, 44 sustained serious injuries, and 143 sustained slight injuries. The number of fatalities in these tractor accidents was about 1.3% of all deaths in traffic accidents in Sweden. Cars were most often involved in the tractor accidents (58%) and 15% were single vehicle accidents. The mean age of the tractor driver involved was 39.8 years and young drivers (15-24 years) were overrepresented (30%). We are now increasing the data collected with the years 2006-2010 in order to study the changes in the number of accidents. Special attention will be given to the younger drivers and to single vehicle accidents. Based on the results we aim to develop suggestions for reducing road accidents, e.g. including measures for making farm vehicles more visible and improvement of the training provided at driving schools. PMID:22317543

  8. Postcranial skeletal pneumaticity and air-sacs in the earliest pterosaurs

    PubMed Central

    Butler, Richard J.; Barrett, Paul M.; Gower, David J.

    2009-01-01

    Patterns of postcranial skeletal pneumatization (PSP) indicate that pterosaurs possessed components of a bird-like respiratory system, including a series of ventilatory air-sacs. However, the presence of PSP in the oldest known pterosaurs has not been unambiguously demonstrated by previous studies. Here we provide the first unequivocal documentation of PSP in Late Triassic and earliest Jurassic pterosaurs. This demonstrates that PSP and, by inference, air-sacs were probably present in the common ancestor of almost all known pterosaurs, and has broader implications for the evolution of respiratory systems in bird-line archosaurs, including dinosaurs. PMID:19411265

  9. Endolymphatic Sac Tumor Showing Increased Activity on 68Ga DOTATATE PET/CT.

    PubMed

    Papadakis, Georgios Z; Millo, Corina; Sadowski, Samira M; Bagci, Ulas; Patronas, Nicholas J

    2016-10-01

    Endolymphatic sac tumors (ELSTs) are rare tumors arising from the epithelium of the endolymphatic sac and duct that can be either sporadic or associated with von Hippel-Lindau (VHL) disease. We report a case of a VHL patient with histologically proven residual ELST who underwent Ga DOTATATE PET/CT showing increased activity (SUVmax, 6.29) by the ELST. The presented case of a VHL-associated ELST with increased Ga DOTATATE uptake indicates cell-surface expression of somatostatin receptors by this tumor, suggesting the potential application of somatostatin receptor imaging using Ga DOTA-conjugated peptides in the workup and management of these patients. PMID:27454593

  10. [Skateboard and rollerskate accidents].

    PubMed

    Lohmann, M; Petersen, A O; Pedersen, O D

    1990-05-28

    The increasing popularity of skateboards and rollerskates has resulted in an increased number of contacts with the casualty department in Denmark after accidents. As part of the Danish share in the EHLASS project (European Home and Leisure Surveillance System), 120,000 consecutive contacts with the casualty departments were reviewed. Out of these 516 were due to accidents with skateboards and rollerskates (181/335). A total of 194 of these injuries (38%) were fractures and 80% of these were in the upper limbs. Twenty fractures required reposition under general anaesthesia and two required osteosynthesis. Nine patients were admitted for observation for concussion. One patient had sustained rupture of the spleen and splenectomy was necessary. A total of 44 patients were admitted. None of the 516 patients had employed protective equipment on the injured region. Considerable reduction in the number of injuries could probably be produced by employment of suitable protective equipment.

  11. [Drowning accidents in childhood].

    PubMed

    Krandick, G; Mantel, K

    1990-09-30

    This is a report on five boys aged between 1 and 5 years who, after prolonged submersion in cold water, were treated at our department. On being taken out of the water, all the patients were clinically dead. After 1- to 3-hour successful cardiopulmonary resuscitation, with a rectal temperature of about 27 degrees C, they were rewarmed at a rate of 1 degree/hour. Two patients died within a few hours after the accident. One patient survived with an apallic syndrome, 2 children survived with no sequelae. In the event of a water-related accident associated with hypothermia, we consider suitable resuscitation to have preference over rewarming measures. The most important treatment guidelines and prognostic factors are discussed.

  12. Farm accidents in children.

    PubMed

    Cogbill, T H; Busch, H M; Stiers, G R

    1985-10-01

    During a 6 1/2 year period, 105 children were admitted to the hospital as the result of trauma that occurred on farms. The mechanism of injury was animal related in 42 (40%), tractor or wagon accident in 28 (26%), farm machinery in 21 (20%), fall from farm building in six (6%), and miscellaneous in eight (8%). Injury Severity Score was calculated for each patient. An Injury Severity Score of greater than or equal to 25 was determined for 11 children (11%). Life-threatening injuries, therefore, are frequently the result of childhood activities that take place in agricultural environments. The most common injuries were orthopedic, neurologic, thoracoabdominal, and maxillofacial. There was one death in the series, and only one survivor sustained major long-term disability. Such injuries are managed with optimal outcome in a regional trauma center. Educational programs with an emphasis on prevention and safety measures may reduce the incidence of farm accidents. PMID:4047799

  13. Severe Accident Test Station Design Document

    SciTech Connect

    Snead, Mary A.; Yan, Yong; Howell, Michael; Keiser, James R.; Terrani, Kurt A.

    2015-09-01

    The purpose of the ORNL severe accident test station (SATS) is to provide a platform for evaluation of advanced fuels under projected beyond design basis accident (BDBA) conditions. The SATS delivers the capability to map the behavior of advanced fuels concepts under accident scenarios across various temperature and pressure profiles, steam and steam-hydrogen gas mixtures, and thermal shock. The overall facility will include parallel capabilities for examination of fuels and irradiated materials (in-cell) and non-irradiated materials (out-of-cell) at BDBA conditions as well as design basis accident (DBA) or loss of coolant accident (LOCA) conditions. Also, a supporting analytical infrastructure to provide the data-needs for the fuel-modeling components of the Fuel Cycle Research and Development (FCRD) program will be put in place in a parallel manner. This design report contains the information for the first, second and third phases of design and construction of the SATS. The first phase consisted of the design and construction of an out-of-cell BDBA module intended for examination of non-irradiated materials. The second phase of this work was to construct the BDBA in-cell module to test irradiated fuels and materials as well as the module for DBA (i.e. LOCA) testing out-of-cell, The third phase was to build the in-cell DBA module. The details of the design constraints and requirements for the in-cell facility have been closely captured during the deployment of the out-of-cell SATS modules to ensure effective future implementation of the in-cell modules.

  14. Effects on accidents of periodic motor vehicle inspection in Norway.

    PubMed

    Christensen, Peter; Elvik, Rune

    2007-01-01

    An extensive programme of periodic motor vehicle inspection was introduced in Norway after 1995, when the treaty between Norway and the European Union (EU) granting Norway (not a member of the EU) access to the EU inner market took effect (The EEA treaty). This paper evaluates the effects on accidents of periodic inspections of cars. Trucks and buses were not included in the study. Negative binomial regression models were fitted to data on accidents and inspections created by merging data files provided by a major insurance company and by the Public Roads Administration. Technical defects prior to inspection were associated with an increased accident rate. Inspections were found to strongly reduce the number of technical defects in cars. Despite this, no effect of inspections on accident rate were found. This finding is inconsistent with the fact that technical defects appear to increase the accident rate; one would expect the repair of such defects to reduce the accident rate. Potential explanations of the findings in terms of behavioural adaptation among car owners are discussed. It is suggested that car owners adapt driving behaviour to the technical condition of the car and that the effect attributed to technical defects before inspection may in part be the result of a tendency for owners who are less concerned about safety to neglect the technical condition of their cars. These car owners might have had a higher accident rate than other car owners irrespective of the technical condition of the car.

  15. Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes.

    PubMed

    Aires, M B; Santos, J R A; Souza, K S; Farias, P S; Santos, A C V; Fioretto, E T; Maria, D A

    2015-08-01

    The function of the visceral yolk sac (VYS) is critical for embryo organogenesis until final fetal development in rats, and can be affected by conditions such as diabetes. In view of the importance of diabetes during pregnancy for maternal and neonatal health, the objective of this study was to assess fetal weight, VYS cell markers, and viability in female Wistar rats (200-250 g) with induced diabetes (alloxan, 37 mg/kg) on the 8th gestational day (gd 8). At gd 15, rats from control (n=5) and diabetic (n=5) groups were anesthetized and laparotomized to remove the uterine horns for weighing of fetuses and collecting the VYS. Flow cytometry was used for characterizing VYS cells, and for determining mitochondrial activity, cell proliferation, DNA ploidy, cell cycle phases, and caspase-3 activity. Fetal weight was reduced in the diabetic group. Expression of the cell markers CD34, VEGFR1, CD115, CD117, CD14, CCR2, CD90, CD44, STRO-1, OCT3/4, and Nanog was detected in VYS cells in both groups. In the diabetic group, significantly decreased expression of CD34 (P<0.05), CCR2 (P<0.001), and OCT3/4 (P<0.01), and significantly increased expression of CD90 (P<0.05), CD117 (P<0.01), and CD14 (P<0.05) were observed. VYS cells with inactive mitochondria, activated caspase-3, and low proliferation were present in the rats with diabetes. Severe hyperglycemia caused by maternal diabetes had negative effects on pregnancy, VYS cell viability, and the expression of cell markers. PMID:26176314

  16. The actin-related protein Sac1 is required for morphogenesis and cell wall integrity in Candida albicans.

    PubMed

    Zhang, Bing; Yu, Qilin; Jia, Chang; Wang, Yuzhou; Xiao, Chenpeng; Dong, Yijie; Xu, Ning; Wang, Lei; Li, Mingchun

    2015-08-01

    Candida albicans is a common pathogenic fungus and has aroused widespread attention recently. Actin cytoskeleton, an important player in polarized growth, protein secretion and organization of cell shape, displays irreplaceable role in hyphal development and cell integrity. In this study, we demonstrated a homologue of Saccharomyces cerevisiae Sac1, in C. albicans. It is a potential PIP phosphatase with Sac domain which is related to actin organization, hyphal development, biofilm formation and cell wall integrity. Deletion of SAC1 did not lead to insitiol-auxotroph phenotype in C. albicans, but this gene rescued the growth defect of S. cerevisiae sac1Δ in the insitiol-free medium. Hyphal induction further revealed the deficiency of sac1Δ/Δ in hyphal development and biofilm formation. Fluorescence observation and real time PCR (RT-PCR) analysis suggested both actin and the hyphal cell wall protein Hwp1 were overexpressed and mislocated in this mutant. Furthermore, cell wall integrity (CWI) was largely affected by deletion of SAC1, due to the hypersensitivity to cell wall stress, changed content and distribution of chitin in the mutant. As a result, the virulence of sac1Δ/Δ was seriously attenuated. Taken together, this study provides evidence that Sac1, as a potential PIP phosphatase, is essential for actin organization, hyphal development, CWI and pathogenicity in C. albicans.

  17. [Chernobyl nuclear power plant accident and Tokaimura criticality accident].

    PubMed

    Takada, Jun

    2012-03-01

    It is clear from inspection of historical incidents that the scale of disasters in a nuclear power plant accident is quite low level overwhelmingly compared with a nuclear explosion in nuclear war. Two cities of Hiroshima and Nagasaki were destroyed by nuclear blast with about 20 kt TNT equivalent and then approximately 100,000 people have died respectively. On the other hand, the number of acute death is 30 in the Chernobyl nuclear reactor accident. In this chapter, we review health hazards and doses in two historical nuclear incidents of Chernobyl and Tokaimura criticality accident and then understand the feature of the radiation accident in peaceful utilization of nuclear power.

  18. Modeling the Rate-Dependent Durability of Reduced-Ag SAC Interconnects for Area Array Packages Under Torsion Loads

    NASA Astrophysics Data System (ADS)

    Srinivas, Vikram; Menon, Sandeep; Osterman, Michael; Pecht, Michael G.

    2013-08-01

    Solder durability models frequently focus on the applied strain range; however, the rate of applied loading, or strain rate, is also important. In this study, an approach to incorporate strain rate dependency into durability estimation for solder interconnects is examined. Failure data were collected for SAC105 solder ball grid arrays assembled with SAC305 solder that were subjected to displacement-controlled torsion loads. Strain-rate-dependent (Johnson-Cook model) and strain-rate-independent elastic-plastic properties were used to model the solders in finite-element simulation. Test data were then used to extract damage model constants for the reduced-Ag SAC solder. A generalized Coffin-Manson damage model was used to estimate the durability. The mechanical fatigue durability curve for reduced-silver SAC solder was generated and compared with durability curves for SAC305 and Sn-Pb from the literature.

  19. The corn snake yolk sac becomes a solid tissue filled with blood vessels and yolk-rich endodermal cells

    PubMed Central

    Elinson, Richard P.; Stewart, James R.

    2014-01-01

    The amniote egg was a key innovation in vertebrate evolution because it supports an independent existence in terrestrial environments. The egg is provisioned with yolk, and development depends on the yolk sac for the mobilization of nutrients. We have examined the yolk sac of the corn snake Pantherophis guttatus by the dissection of living eggs. In contrast to the familiar fluid-filled sac of birds, the corn snake yolk sac invades the yolk mass to become a solid tissue. There is extensive proliferation of yolk-filled endodermal cells, which associate with a meshwork of blood vessels. These novel attributes of the yolk sac of corn snakes compared with birds suggest new pathways for the evolution of the amniote egg. PMID:24402715

  20. Effects of granulation on organic acid metabolism and its relation to mineral elements in Citrus grandis juice sacs.

    PubMed

    Wang, Xian-You; Wang, Ping; Qi, Yi-Ping; Zhou, Chen-Ping; Yang, Lin-Tong; Liao, Xin-Yan; Wang, Liu-Qing; Zhu, Dong-Huang; Chen, Li-Song

    2014-02-15

    We investigated the effects of granulation on organic acid metabolism and its relation to mineral elements in 'Guanximiyou' pummelo (Citrus grandis) juice sacs. Granulated juice sacs had decreased concentrations of citrate and isocitrate, thus lowering juice sac acidity. By contrast, malate concentration was higher in granulated juice sacs than in normal ones. The reduction in citrate concentration might be caused by increased degradation, as indicated by enhanced aconitase activity, whilst the increase in malate concentration might be caused by increased biosynthesis, as indicated by enhanced phosphoenolpyruvate carboxylase (PEPC). Real time quantitative reverse transcription PCR (qRT-PCR) analysis showed that the activities of most acid-metabolizing enzymes were regulated at the transcriptional level, whilst post-translational modifications might influence the PEPC activity. Granulation led to increased accumulation of mineral elements (especially phosphorus, magnesium, sulphur, zinc and copper) in juice sacs, which might be involved in the incidence of granulation in pummelo fruits.

  1. 2 CFR Appendix X to Part 200 - Data Collection Form (Form SF-SAC)

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Data Collection Form (Form SF-SAC) X Appendix X to Part 200 Grants and Agreements Office of Management and Budget Guidance for Grants and... PRINCIPLES, AND AUDIT REQUIREMENTS FOR FEDERAL AWARDS Pt. 200, App. X Appendix X to Part 200—Data...

  2. Yolk sac tumor of the seminal vesicles: A rare malignant cause of hematospermia.

    PubMed

    Gill, Jonathan D; Bhattarai, Selina; Patel, Chirag N; Paul, Alan B

    2015-01-01

    Extra-gonadal yolk sac tumors (YSTs) are rare and generally associated with poor outcomes. Involvement of the seminal vesicles is extremely rare with only one previously described case. We report a case of a primary YST of the seminal vesicles and discuss the management strategy.

  3. Ventilation patterns of the songbird lung/air sac system during different behaviors

    PubMed Central

    Mackelprang, Rebecca; Goller, Franz

    2013-01-01

    SUMMARY Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system. PMID:23788706

  4. Ventilation patterns of the songbird lung/air sac system during different behaviors.

    PubMed

    Mackelprang, Rebecca; Goller, Franz

    2013-10-01

    Unidirectional, continuous airflow through the avian lung is achieved through an elaborate air sac system with a sequential, posterior to anterior ventilation pattern. This classical model was established through various approaches spanning passively ventilated systems to mass spectrometry analysis of tracer gas flow into various air sacs during spontaneous breathing in restrained ducks. Information on flow patterns in other bird taxa is missing, and these techniques do not permit direct tests of whether the basic flow pattern can change during different behaviors. Here we use thermistors implanted into various locations of the respiratory system to detect small pulses of tracer gas (helium) to reconstruct airflow patterns in quietly breathing and behaving (calling, wing flapping) songbirds (zebra finch and yellow-headed blackbird). The results illustrate that the basic pattern of airflow in these two species is largely consistent with the model. However, two notable differences emerged. First, some tracer gas arrived in the anterior set of air sacs during the inspiration during which it was inhaled, suggesting a more rapid throughput through the lung than previously assumed. Second, differences in ventilation between the two anterior air sacs emerged during calling and wing flapping, indicating that adjustments in the flow pattern occur during dynamic behaviors. It is unclear whether this modulation in ventilation pattern is passive or active. This technique for studying ventilation patterns during dynamic behaviors proves useful for establishing detailed timing of airflow and modulation of ventilation in the avian respiratory system.

  5. Testicular yolk sac tumor and impaired spermatogenesis in a Holstein Friesian calf.

    PubMed

    Schindewolffs, Lia; Dierks, Claudia; Heppelmann, Maike; Gähle, Marion; Piechotta, Marion; Beineke, Andreas; Brehm, Ralph; Distl, Ottmar

    2015-01-01

    Yolk sac tumors are testicular germ-cell tumors of the non-seminoma type. In cattle, this neoplasm is very rare and to date has only been described three times. In human males, it usually occurs in infants and children. Immunohistochemistry provides solid criteria for diagnostics. Especially present pathognomonic Schiller-Duval bodies are helpful for identification. In this report, a 32-day-old Holstein Friesian calf presented with a highly enlarged right testis. Sonographic examination was performed and blood samples were taken to measure testosterone and estrogen levels. Furthermore, the testis was surgically removed and macroscopically, histologically, and immunohistochemically examined which lead to the diagnosis of testicular yolk sac tumor. The second testis was descended until the age of nine months and histology revealed impaired spermatogenesis. This report provides the first sonographic images of bovine testicular yolk sac tumor as well as the first information about hormone levels in calves with this neoplasm. It also shows the importance to combine anamnesis, histomorphological, and immunohistochemical findings in order to diagnose yolk sac tumors when pathognomonic structures are not present.

  6. 48 CFR 301.603-72 - FAC-C and HHS SAC certification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false FAC-C and HHS SAC certification requirements. 301.603-72 Section 301.603-72 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority,...

  7. 38 CFR Appendix A to Part 41 - Data Collection Form (Form SF-SAC)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Data Collection Form (Form SF-SAC) A Appendix A to Part 41 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Pt. 41, App. A,...

  8. Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor

    PubMed Central

    Boussios, Stergios; Moschetta, Michele; McLachlan, Jennifer; Banerjee, Susana

    2015-01-01

    Flagellate linear hyperpigmentation can rarely be caused by the chemotherapy agent, bleomycin. Herein, we describe the case of a 20-year-old woman treated with bleomycin for an ovarian yolk sac tumor and review the prominent features of this form of dermatitis. PMID:26798532

  9. Cells of the connective tissue differentiate and migrate into pollen sacs

    NASA Astrophysics Data System (ADS)

    Iqbal, M. C. M.; Wijesekara, Kolitha B.

    2002-01-01

    In angiosperms, archesporial cells in the anther primordium undergo meiosis to form haploid pollen, the sole occupants of anther sacs. Anther sacs are held together by a matrix of parenchyma cells, the connective tissue. Cells of the connective tissue are not known to differentiate. We report the differentiation of parenchyma cells in the connective tissue of two Gordonia species into pollen-like structures (described as pseudopollen), which migrate into the anther sacs before dehiscence. Pollen and pseudopollen were distinguishable by morphology and staining. Pollen were tricolpate to spherical while pseudopollen were less rigid and transparent with a ribbed surface. Both types were different in size, shape, staining and surface architecture. The ratio of the number of pseudopollen to pollen was 1:3. During ontogeny in the connective tissue, neither cell division nor tetrad formation was observed and hence pseudopollen were presumed to be diploid. Only normal pollen germinated on a germination medium. Fixed preparations in time seemed to indicate that pseudopollen migrate from the connective tissue into the anther sac.

  10. An observing system simulation experiment (OSSE) for the aquarius/SAC-D soil moisture product

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An Observing System Simulation Experiment for the Aquarius/SAC-D mission has been developed for assessing the accuracy of soil moisture retrievals from passive L-band remote sensing. The implementation of the OSSE is based on: a 1-km land surface model over the Red-Arkansas River Basin, a forward mi...

  11. Entire lacrimal sac within the ethmoid sinus: outcomes of powered endoscopic dacryocystorhinostomy

    PubMed Central

    Ali, Mohammad Javed; Singh, Swati; Naik, Milind N

    2016-01-01

    Background The aim of this study was to report the outcomes of powered endoscopic dacryocystorhinostomy (PEnDCR) in patients with lacrimal sac within the sinus. Materials and methods Retrospective analysis was performed on all patients who underwent PEnDCR and were intraoperatively documented to have complete lacrimal sac in sinus. Data collected included demographics, clinical presentations, associated lacrimal and nasal anomalies, intraoperative findings, intraoperative guidance, complications, postoperative ostium behavior, and anatomical and functional success. A minimum follow-up of 6 months postsurgery was considered for final analysis. Results A total of 17 eyes of 15 patients underwent PEnDCR using standard protocols, but with additional intraoperative guidance where required and careful maneuvering in the ethmoid sinus. The mean age of the patients was 37.2 (range 17–60) years. Of the unilateral cases, 69% (nine of 13) showed left-side predisposition; 80% of patients showed regurgitation on pressure over the lacrimal sac area. Associated lacrimal and nasal anomalies were observed in 13.3% (two of 15) and 40% (six of 15), respectively. At a mean follow-up of 6.6 months, anatomical and functional success were observed in 93.3% (14 of 15). One patient showed failure secondary to cicatricial closure of the ostium. Conclusion An entire sac within an ethmoid sinus poses a surgical challenge. Good sinus-surgery training, thorough knowledge of endoscopic anatomy, careful maneuvering, and use of intraoperative navigation guidance result in good outcomes with PEnDCR. PMID:27462137

  12. Regulation of ascorbic acid metabolism by blue LED light irradiation in citrus juice sacs.

    PubMed

    Zhang, Lancui; Ma, Gang; Yamawaki, Kazuki; Ikoma, Yoshinori; Matsumoto, Hikaru; Yoshioka, Terutaka; Ohta, Satoshi; Kato, Masaya

    2015-04-01

    In the present study, the effects of red and blue LED lights on the accumulation of ascorbic acid (AsA) were investigated in the juice sacs of three citrus varieties, Satsuma mandarin, Valencia orange, and Lisbon lemon. The results showed that the blue LED light treatment effectively increased the AsA content in the juice sacs of the three citrus varieties, whereas the red LED light treatment did not. By increasing the blue LED light intensity, the juice sacs of the three citrus varieties accumulated more AsA. Moreover, continuous irradiation with blue LED light was more effective than pulsed irradiation for increasing the AsA content in the juice sacs of the three citrus varieties. Gene expression results showed that the modulation of AsA accumulation by blue LED light was highly regulated at the transcription level. The up-regulation of AsA biosynthetic genes (CitVTC1, CitVTC2, CitVTC4, and CitGLDH), AsA regeneration genes (CitMDAR1, CitMDAR2, and CitDHAR) and two GSH-producing genes (CitGR and CitchGR) contributed to these increases in the AsA content in the three citrus varieties.

  13. Late Sac Behavior after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm

    PubMed Central

    Okada, Masahiro; Onohara, Toshihiro; Okamoto, Minoru; Yamamoto, Tsuyoshi; Shimoe, Yasushi; Yamashita, Masafumi; Takahashi, Toshiki; Kishimoto, Jyunji; Mizuno, Akihiro; Kei, Junichi; Nakai, Mikizou; Sakaki, Masayuki; Suhara, Hitoshi; Kasashima, Fuminori; Endo, Masamitsu; Nishina, Takeshi; Furuyama, Tadashi; Kawasaki, Masakazu; Iwata, Keiji; Marumoto, Akira; Urata, Yasuhisa; Sato, Katsutoshi; Ryugo, Masahiro

    2016-01-01

    Background: Sac behavior after endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs) is considered as a surrogate for the risk of late rupture. The purpose of the study is to assess the sac behavior of AAAs after EVAR. Methods and Results: Late sac enlargement (LSE) (≥5 mm) and late sac shrinkage (LSS) (≥5 mm) were analyzed in 589 consecutive patients who were registered at 14 national centers in Japan. The proportions of patients who had LSE at 1, 3 and 5 years were 2.6% ± 0.7%, 10.0% ± 1.6% and 19.0% ± 2.9%. The proportions of patients who had LSS at 1, 3 and 5 years were 50.1% ± 0.7%, 59.2% ± 2.3% and 61.7% ± 2.7%. Multiple logistic regression analysis identified two variables as a risk factor for LSE; persistent endoleak (Odds ratio 9.56 (4.84–19.49), P <0.001) and low platelet count (Odds ratio 0.92 (0.86–0.99), P = 0.0224). The leading cause of endoleak in patients with LSE was type II. Conclusions: The incidence of LSE is not negligible over 5 year period. Patients with persistent endoleak and/or low platelet count should carefully be observed for LSE. Clinical Trial Registration: UMIN-CTR (UMIN000008345). PMID:27375803

  14. Severe accident approach - final report. Evaluation of design measures for severe accident prevention and consequence mitigation.

    SciTech Connect

    Tentner, A. M.; Parma, E.; Wei, T.; Wigeland, R.; Nuclear Engineering Division; SNL; INL

    2010-03-01

    An important goal of the US DOE reactor development program is to conceptualize advanced safety design features for a demonstration Sodium Fast Reactor (SFR). The treatment of severe accidents is one of the key safety issues in the design approach for advanced SFR systems. It is necessary to develop an in-depth understanding of the risk of severe accidents for the SFR so that appropriate risk management measures can be implemented early in the design process. This report presents the results of a review of the SFR features and phenomena that directly influence the sequence of events during a postulated severe accident. The report identifies the safety features used or proposed for various SFR designs in the US and worldwide for the prevention and/or mitigation of Core Disruptive Accidents (CDA). The report provides an overview of the current SFR safety approaches and the role of severe accidents. Mutual understanding of these design features and safety approaches is necessary for future collaborations between the US and its international partners as part of the GEN IV program. The report also reviews the basis for an integrated safety approach to severe accidents for the SFR that reflects the safety design knowledge gained in the US during the Advanced Liquid Metal Reactor (ALMR) and Integral Fast Reactor (IFR) programs. This approach relies on inherent reactor and plant safety performance characteristics to provide additional safety margins. The goal of this approach is to prevent development of severe accident conditions, even in the event of initiators with safety system failures previously recognized to lead directly to reactor damage.

  15. Myocardial longitudinal peak systolic acceleration (pSac): relationship to ejection phase, pressure, and contractility.

    PubMed

    Odland, Hans Henrik; Brun, Henrik; Sejersted, Yngve; Dalen, Marit; Edvardsen, Thor; Saugstad, Ola Didrik; Thaulow, Erik

    2012-05-01

    Acceleration has been measured both noninvasively and invasively, during both isovolumic contraction and early ejection and has been shown to reflect contractility, especially through correlation with dP/dt(max) . In this study timing and amplitude of mitral valve annulus acceleration assessed by tissue Doppler were measured and related to diastolic and systolic events. Invasive load independent measures of contractility, based on pressure-volume relationships, were derived, and pacing was done to modulate and control heart rate. Peak systolic acceleration (pSac) of the mitral valve annulus was shown to occur slightly later but timely related to dP/dt(max) (P < 0.05), while peak preejection acceleration (pPac) was related to diastolic events. During inotropy and preload modulation dP/dt(max) was found to be the strongest determinant of pSac (β= 0.9 ± 0.1; P < 0.001 and β= 1.3 ± 0.4; P < 0.001, respectively, log-transformed variables). PSac increased with pacing at a higher rate (β= 0.1 ± 0.0 cm/sec(2), P = 0.03). Furthermore, pSac indexed to end-diastolic volume (EDV) was linearly correlated to load independent contractility parameters (E(max), R = 0.7; ESPVR, R = 0.7; and PRSW, R = 0.5), and proved stable toward changes in preload and afterload. The relation between dP/dt(max)/EDV and pSac/EDV was stable throughout the study. In conclusion we found that peak systolic longitudinal acceleration (pSac) of the mitral valve annulus during aortic valve opening is strongly associated with dP/dt(max). Indexed to EDV, pSac may represent a load independent noninvasive contractility parameter. We consider pSac a candidate marker of long-axis contractility which should be viewed upon as the long-axis contribution to dP/dt(max).

  16. SAC-SMA a priori parameter differences and their impact on distributed hydrologic model simulations

    NASA Astrophysics Data System (ADS)

    Zhang, Ziya; Koren, Victor; Reed, Seann; Smith, Michael; Zhang, Yu; Moreda, Fekadu; Cosgrove, Brian

    2012-02-01

    SummaryDeriving a priori gridded parameters is an important step in the development and deployment of an operational distributed hydrologic model. Accurate a priori parameters can reduce the manual calibration effort and/or speed up the automatic calibration process, reduce calibration uncertainty, and provide valuable information at ungauged locations. Underpinned by reasonable parameter data sets, distributed hydrologic modeling can help improve water resource and flood and flash flood forecasting capabilities. Initial efforts at the National Weather Service Office of Hydrologic Development (NWS OHD) to derive a priori gridded Sacramento Soil Moisture Accounting (SAC-SMA) model parameters for the conterminous United States (CONUS) were based on a relatively coarse resolution soils property database, the State Soil Geographic Database (STATSGO) (Soil Survey Staff, 2011) and on the assumption of uniform land use and land cover. In an effort to improve the parameters, subsequent work was performed to fully incorporate spatially variable land cover information into the parameter derivation process. Following that, finer-scale soils data (the county-level Soil Survey Geographic Database (SSURGO) ( Soil Survey Staff, 2011a,b), together with the use of variable land cover data, were used to derive a third set of CONUS, a priori gridded parameters. It is anticipated that the second and third parameter sets, which incorporate more physical data, will be more realistic and consistent. Here, we evaluate whether this is actually the case by intercomparing these three sets of a priori parameters along with their associated hydrologic simulations which were generated by applying the National Weather Service Hydrology Laboratory's Research Distributed Hydrologic Model (HL-RDHM) ( Koren et al., 2004) in a continuous fashion with an hourly time step. This model adopts a well-tested conceptual water balance model, SAC-SMA, applied on a regular spatial grid, and links to physically

  17. Crystal plasticity finite element analysis of deformation behaviour in SAC305 solder joint

    NASA Astrophysics Data System (ADS)

    Darbandi, Payam

    Due to the awareness of the potential health hazards associated with the toxicity of lead (Pb), actions have been taken to eliminate or reduce the use of Pb in consumer products. Among those, tin (Sn) solders have been used for the assembly of electronic systems. Anisotropy is of significant importance in all structural metals, but this characteristic is unusually strong in Sn, making Sn based solder joints one of the best examples of the influence of anisotropy. The effect of anisotropy arising from the crystal structure of tin and large grain microstructure on the microstructure and the evolution of constitutive responses of microscale SAC305 solder joints is investigated. Insights into the effects of key microstructural features and dominant plastic deformation mechanisms influencing the measured relative activity of slip systems in SAC305 are obtained from a combination of optical microscopy, orientation imaging microscopy (OIM), slip plane trace analysis and crystal plasticity finite element (CPFE) modeling. Package level SAC305 specimens were subjected to shear deformation in sequential steps and characterized using optical microscopy and OIM to identify the activity of slip systems. X-ray micro Laue diffraction and high energy monochromatic X-ray beam were employed to characterize the joint scale tensile samples to provide necessary information to be able to compare and validate the CPFE model. A CPFE model was developed that can account for relative ease of activating slip systems in SAC305 solder based upon the statistical estimation based on correlation between the critical resolved shear stress and the probability of activating various slip systems. The results from simulations show that the CPFE model developed using the statistical analysis of activity of slip system not only can satisfy the requirements associated with kinematic of plastic deformation in crystal coordinate systems (activity of slip systems) and global coordinate system (shape changes

  18. Electromigration effect on intermetallic growth and Young's modulus in SAC solder joint

    NASA Astrophysics Data System (ADS)

    Xu, Luhua; Pang, John H. L.; Ren, Fei; Tu, K. N.

    2006-12-01

    Solid-state intermetallic compound (IMC) growth behavior plays and important role in solder joint reliability of electronic packaging assemblies. The directional impact of electromigration (EM) on the growth of interfacial IMCs in Ni/SAC/Ni, Cu/SAC/Ni single BGA ball solder joint, and fine pitch ball-grid-array (FPBGA) at the anode and cathode sides is reported in this study. When the solder joint was subjected to a current density of 5,000 A/cm2 at 125°C or 150°C, IMC layer growth on the anode interface was faster than that on the cathode interface, and both were faster than isothermal aging due to the Joule heating effect. The EM affects the IMC growth rate, as well as the composition and mechanical properties. The Young’s modulus and hardness were measured by the nanoindentation continuous stiffness measurement (CSM) from planar IMC surfaces after EM exposure. Different values were observed at the anode and cathode. The energy-dispersive x-ray (EDX) line scan analysis was conducted at the interface from the cathode to anode to study the presence of species; Ni was found in the anode IMC at SAC/Cu in the Ni/SAC/Cu joint, but not detected when the current was reverse. Electron-probe microanalysis (EPMA) measurement on the Ni/SAC/Ni specimen also confirmed the polarized Ni and Cu distributions in cathode and anode IMCs, which were (Ni0.57Cu0.43)3Sn4 and (Cu0.73Ni0.27)6Sn5, respectively. Thus, the Young’s moduli of the IMC are 141 and 175 GPa, respectively.

  19. Transportation accidents/incidents involving radioactive materials (1971--1991)

    SciTech Connect

    Cashwell, C. E.; McClure, J. D.

    1992-01-01

    The Radioactive Materials Incident Report (RMIR) database contains information on transportation-related accidents and incidents involving radioactive materials that have occurred in the United States. The RMIR was developed at Sandia National Laboratories (SNL) to support its research and development program efforts for the US Department of Energy (DOE). This paper will address the following topics: background information on the regulations and process for reporting a hazardous materials transportation incident, overview data of radioactive materials transportation accidents and incidents, and additional information and summary data on how packagings have performed in accident conditions.

  20. [Principles of intervertebral disc assessment in private accident insurance].

    PubMed

    Steinmetz, M; Dittrich, V; Röser, K

    2015-09-01

    Due to the spread of intervertebral disc degeneration, insurance companies and experts are regularly confronted with related assessments of insured persons under their private accident insurance. These claims pose a particular challenge for experts, since, in addition to the clinical assessment of the facts, extensive knowledge of general accident insurance conditions, case law and current study findings is required. Each case can only be properly assessed through simultaneous consideration of both the medical and legal facts. These guidelines serve as the basis for experts and claims.managers with respect to the appropriate individual factual assessment of intervertebral disc degeneration in private accident insurance. PMID:26548005

  1. The Fukushima accident was preventable.

    PubMed

    Synolakis, Costas; Kânoğlu, Utku

    2015-10-28

    The 11 March 2011 tsunami was probably the fourth largest in the past 100 years and killed over 15 000 people. The magnitude of the design tsunami triggering earthquake affecting this region of Japan had been grossly underestimated, and the tsunami hit the Fukushima Dai-ichi nuclear power plant (NPP), causing the third most severe accident in an NPP ever. Interestingly, while the Onagawa NPP was also hit by a tsunami of approximately the same height as Dai-ichi, it survived the event 'remarkably undamaged'. We explain what has been referred to as the cascade of engineering and regulatory failures that led to the Fukushima disaster. One, insufficient attention had been given to evidence of large tsunamis inundating the region earlier, to Japanese research suggestive that large earthquakes could occur anywhere along a subduction zone, and to new research on mega-thrusts since Boxing Day 2004. Two, there were unexplainably different design conditions for NPPs at close distances from each other. Three, the hazard analysis to calculate the maximum probable tsunami at Dai-ichi appeared to have had methodological mistakes, which almost nobody experienced in tsunami engineering would have made. Four, there were substantial inadequacies in the Japan nuclear regulatory structure. The Fukushima accident was preventable, if international best practices and standards had been followed, if there had been international reviews, and had common sense prevailed in the interpretation of pre-existing geological and hydrodynamic findings. Formal standards are needed for evaluating the tsunami vulnerability of NPPs, for specific training of engineers and scientists who perform tsunami computations for emergency preparedness or critical facilities, as well as for regulators who review safety studies.

  2. The Fukushima accident was preventable.

    PubMed

    Synolakis, Costas; Kânoğlu, Utku

    2015-10-28

    The 11 March 2011 tsunami was probably the fourth largest in the past 100 years and killed over 15 000 people. The magnitude of the design tsunami triggering earthquake affecting this region of Japan had been grossly underestimated, and the tsunami hit the Fukushima Dai-ichi nuclear power plant (NPP), causing the third most severe accident in an NPP ever. Interestingly, while the Onagawa NPP was also hit by a tsunami of approximately the same height as Dai-ichi, it survived the event 'remarkably undamaged'. We explain what has been referred to as the cascade of engineering and regulatory failures that led to the Fukushima disaster. One, insufficient attention had been given to evidence of large tsunamis inundating the region earlier, to Japanese research suggestive that large earthquakes could occur anywhere along a subduction zone, and to new research on mega-thrusts since Boxing Day 2004. Two, there were unexplainably different design conditions for NPPs at close distances from each other. Three, the hazard analysis to calculate the maximum probable tsunami at Dai-ichi appeared to have had methodological mistakes, which almost nobody experienced in tsunami engineering would have made. Four, there were substantial inadequacies in the Japan nuclear regulatory structure. The Fukushima accident was preventable, if international best practices and standards had been followed, if there had been international reviews, and had common sense prevailed in the interpretation of pre-existing geological and hydrodynamic findings. Formal standards are needed for evaluating the tsunami vulnerability of NPPs, for specific training of engineers and scientists who perform tsunami computations for emergency preparedness or critical facilities, as well as for regulators who review safety studies. PMID:26392611

  3. A single bivalent efficiently inhibits cyclin B1 degradation and polar body extrusion in mouse oocytes indicating robust SAC during female meiosis I.

    PubMed

    Hoffmann, Steffen; Maro, Bernard; Kubiak, Jacek Z; Polanski, Zbigniew

    2011-01-01

    The Spindle Assembly Checkpoint (SAC) inhibits anaphase until microtubule-to-kinetochore attachments are formed, thus securing correct chromosome separation and preventing aneuploidy. Whereas in mitosis even a single unattached chromosome keeps the SAC active, the high incidence of aneuploidy related to maternal meiotic errors raises a concern about the lower efficiency of SAC in oocytes. Recently it was suggested that in mouse oocytes, contrary to somatic cells, not a single chromosome but a critical mass of chromosomes triggers efficient SAC pointing to the necessity of evaluating the robustness of SAC in oocytes. Two types of errors in chromosome segregation upon meiosis I related to SAC were envisaged: (1) SAC escape, when kinetochores emit SAC-activating signal unable to stop anaphase I; and (2) SAC deceive, when kinetochores do not emit the signal. Using micromanipulations and live imaging of the first polar body extrusion, as well as the dynamics of cyclin B1 degradation, here we show that in mouse oocytes a single bivalent keeps the SAC active. This is the first direct evaluation of SAC efficiency in mouse oocytes, which provides strong evidence that the robustness of SAC in mammalian oocytes is comparable to other cell types. Our data do not contradict the hypothesis of the critical mass of chromosomes necessary for SAC activation, but suggest that the same rule may govern SAC activity also in other cell types. We postulate that the innate susceptibility of oocytes to errors in chromosome segregation during the first meiotic division may not be caused by lower efficiency of SAC itself, but could be linked to high critical chromosome mass necessary to keep SAC active in oocyte of large size.

  4. Rear-end accident victims. Importance of understanding the accident.

    PubMed Central

    Sehmer, J. M.

    1993-01-01

    Family physicians regularly treat victims of rear-end vehicle accidents. This article describes how taking a detailed history of the accident and understanding the significance of the physical events is helpful in understanding and anticipating patients' morbidity and clinical course. Eight questions to ask patients are suggested to help physicians understand the severity of injury. PMID:8495140

  5. Radiation accident grips Goiania

    SciTech Connect

    Roberts, L.

    1987-11-20

    On 13 September two young scavengers in Goiania, Brazil, removed a stainless steel cylinder from a cancer therapy machine in an abandoned clinic, touching off a radiation accident second only to Chernobyl in its severity. On 18 September they sold the cylinder, the size of a 1-gallon paint can, to a scrap dealer for $25. At the junk yard an employee dismantled the cylinder and pried open the platinum capsule inside to reveal a glowing blue salt-like substance - 1400 curies of cesium-137. Fascinated by the luminescent powder, several people took it home with them. Some children reportedly rubbed in on their bodies like carnival glitter - an eerie image of how wrong things can go when vigilance over radioactive materials lapses. In all, 244 people in Goiania, a city of 1 million in central Brazil, were contaminated. The eventual toll, in terms of cancer or genetic defects, cannot yet be estimated. Parts of the city are cordoned off as radiation teams continue washing down buildings and scooping up radioactive soil. The government is also grappling with the political fallout from the accident.

  6. The effects of aircraft certification rules on general aviation accidents

    NASA Astrophysics Data System (ADS)

    Anderson, Carolina Lenz

    -Square test indicated that there was no significant difference in the number of accidents among the different certification categories when either Controlled Flight into Terrain or Structural Failure was listed as cause. However, there was a significant difference in the frequency of accidents with regard to Loss of Control and Engine Failure accidents. The results of the ANCOVA test indicated that there was no significant difference in the accident rate with regard to Loss of Control, Controlled Flight into Terrain, or Structural Failure accidents. There was, however, a significant difference in Engine Failure accidents between Experimental-Amateur Built and the other categories.The text mining analysis of the narrative causes of Loss of Control accidents indicated that only the Civil Air Regulations 3 category airplanes had clusters of words associated with visual flight into instrument meteorological conditions. Civil Air Regulations 3 airplanes were designed and manufactured prior to the 1960s and in most cases have not been retrofitted to take advantage of newer technologies that could help prevent Loss of Control accidents. The study indicated that General Aviation aircraft certification rules do not have a statistically significant effect on aircraft accidents except for Loss of Control and Engine Failure. According to the literature, government oversight could have become an obstacle in the implementation of safety enhancing equipment that could reduce Loss of Control accidents. Oversight should focus on ensuring that Experimental-Amateur Built aircraft owners perform a functional test that could prevent some of the Engine Failure accidents.

  7. Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.

    PubMed

    Ulbright, Thomas M

    2014-07-01

    Dr Robert E. Scully greatly advanced our understanding of germ cell neoplasia to the extent that it is difficult to narrow the discussion of his contributions to this topic so that it can be covered in a brief article. This article accordingly focuses on some of the recent developments concerning 2 of his major contributions in this area-the gonadoblastoma (GB) and variant morphologies of yolk sac tumor. GB was defined by Dr Scully in 1953 and its features elaborated in detail by him in 1970. This neoplasm occurred in young patients who often displayed phenotypic sex ambiguities and frequently presented with primary amenorrhea. It was bilateral in 40%, and consisted of circumscribed nests of small sex cord cells and germinoma-like cells admixed with round deposits of eosinophilic, hyaline, often calcified material. These nests were set in a spindle cell gonadal stroma with Leydig-like or lutein-like cells. Because of his work we now understand that this precursor to invasive germ cell tumors occurs in patients with a specific form of disorder of sex development, namely gonadal dysgenesis, and only in those who have a particular portion of the Y chromosome, the GB locus/TSPY gene, within the gonadal tissue. An essential element to the development of GB appears to be a defect in the genetic pathway that leads to the development of Sertoli cells. Improperly formed Sertoli cells predispose to "delayed maturation" of the gonocytes of the gonad and predispose them to undergo malignant transformation. "Undifferentiated gonadal tissue" has been proposed as the precursor to the development of GB and consists of an unorganized mixture of apparently non-neoplastic germ cells, germ cells with delayed maturation, and neoplastic germ cells with sex cord cells and gonadal stroma. Two variant morphologies of yolk sac tumor were also recognized by Dr Scully. In the hepatoid variant features similar to hepatocellular carcinoma occurred, although primitive glandular foci and lack of

  8. Explaining the road accident risk: weather effects.

    PubMed

    Bergel-Hayat, Ruth; Debbarh, Mohammed; Antoniou, Constantinos; Yannis, George

    2013-11-01

    This research aims to highlight the link between weather conditions and road accident risk at an aggregate level and on a monthly basis, in order to improve road safety monitoring at a national level. It is based on some case studies carried out in Work Package 7 on "Data analysis and synthesis" of the EU-FP6 project "SafetyNet-Building the European Road Safety Observatory", which illustrate the use of weather variables for analysing changes in the number of road injury accidents. Time series analysis models with explanatory variables that measure the weather quantitatively were used and applied to aggregate datasets of injury accidents for France, the Netherlands and the Athens region, over periods of more than 20 years. The main results reveal significant correlations on a monthly basis between weather variables and the aggregate number of injury accidents, but the magnitude and even the sign of these correlations vary according to the type of road (motorways, rural roads or urban roads). Moreover, in the case of the interurban network in France, it appears that the rainfall effect is mainly direct on motorways--exposure being unchanged, and partly indirect on main roads--as a result of changes in exposure. Additional results obtained on a daily basis for the Athens region indicate that capturing the within-the-month variability of the weather variables and including it in a monthly model highlights the effects of extreme weather. Such findings are consistent with previous results obtained for France using a similar approach, with the exception of the negative correlation between precipitation and the number of injury accidents found for the Athens region, which is further investigated. The outlook for the approach and its added value are discussed in the conclusion.

  9. German aircraft accident statistics, 1930

    NASA Technical Reports Server (NTRS)

    Weitzmann, Ludwig

    1932-01-01

    The investigation of all serious accidents, involving technical defects in the airplane or engine, is undertaken by the D.V.L. in conjunction with the imperial traffic minister and other interested parties. All accidents not clearly explained in the reports are subsequently cleared up.

  10. First Responders and Criticality Accidents

    SciTech Connect

    Valerie L. Putman; Douglas M. Minnema

    2005-11-01

    Nuclear criticality accident descriptions typically include, but do not focus on, information useful to first responders. We studied these accidents, noting characteristics to help (1) first responders prepare for such an event and (2) emergency drill planners develop appropriate simulations for training. We also provide recommendations to help people prepare for such events in the future.

  11. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells

    PubMed Central

    Sarkar, Shayan; Jain, Sumeet; Rai, Vineeta; Sahoo, Dipak K.; Raha, Sumita; Suklabaidya, Sujit; Senapati, Shantibhusan; Rangnekar, Vivek M.; Maiti, Indu B.; Dey, Nrisingha

    2015-01-01

    The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4) selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV) and apoplast signal peptide (aTP) in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR, and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER) was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT), apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era. PMID:26500666

  12. Transport aircraft accident dynamics

    NASA Technical Reports Server (NTRS)

    Cominsky, A.

    1982-01-01

    A study was carried out of 112 impact survivable jet transport aircraft accidents (world wide) of 27,700 kg (60,000 lb.) aircraft and up extending over the last 20 years. This study centered on the effect of impact and the follow-on events on aircraft structures and was confined to the approach, landing and takeoff segments of the flight. The significant characteristics, frequency of occurrence and the effect on the occupants of the above data base were studied and categorized with a view to establishing typical impact scenarios for use as a basis of verifying the effectiveness of potential safety concepts. Studies were also carried out of related subjects such as: (1) assessment of advanced materials; (2) human tolerance to impact; (3) merit functions for safety concepts; and (4) impact analysis and test methods.

  13. Evaluation Metrics Applied to Accident Tolerant Fuels

    SciTech Connect

    Shannon M. Bragg-Sitton; Jon Carmack; Frank Goldner

    2014-10-01

    The safe, reliable, and economic operation of the nation’s nuclear power reactor fleet has always been a top priority for the United States’ nuclear industry. Continual improvement of technology, including advanced materials and nuclear fuels, remains central to the industry’s success. Decades of research combined with continual operation have produced steady advancements in technology and have yielded an extensive base of data, experience, and knowledge on light water reactor (LWR) fuel performance under both normal and accident conditions. One of the current missions of the U.S. Department of Energy’s (DOE) Office of Nuclear Energy (NE) is to develop nuclear fuels and claddings with enhanced accident tolerance for use in the current fleet of commercial LWRs or in reactor concepts with design certifications (GEN-III+). Accident tolerance became a focus within advanced LWR research upon direction from Congress following the 2011 Great East Japan Earthquake, resulting tsunami, and subsequent damage to the Fukushima Daiichi nuclear power plant complex. The overall goal of ATF development is to identify alternative fuel system technologies to further enhance the safety, competitiveness and economics of commercial nuclear power. Enhanced accident tolerant fuels would endure loss of active cooling in the reactor core for a considerably longer period of time than the current fuel system while maintaining or improving performance during normal operations. The U.S. DOE is supporting multiple teams to investigate a number of technologies that may improve fuel system response and behavior in accident conditions, with team leadership provided by DOE national laboratories, universities, and the nuclear industry. Concepts under consideration offer both evolutionary and revolutionary changes to the current nuclear fuel system. Mature concepts will be tested in the Advanced Test Reactor at Idaho National Laboratory beginning in Summer 2014 with additional concepts being

  14. New Technologies for Weather Accident Prevention

    NASA Technical Reports Server (NTRS)

    Stough, H. Paul, III; Watson, James F., Jr.; Daniels, Taumi S.; Martzaklis, Konstantinos S.; Jarrell, Michael A.; Bogue, Rodney K.

    2005-01-01

    Weather is a causal factor in thirty percent of all aviation accidents. Many of these accidents are due to a lack of weather situation awareness by pilots in flight. Improving the strategic and tactical weather information available and its presentation to pilots in flight can enhance weather situation awareness and enable avoidance of adverse conditions. This paper presents technologies for airborne detection, dissemination and display of weather information developed by the National Aeronautics and Space Administration (NASA) in partnership with the Federal Aviation Administration (FAA), National Oceanic and Atmospheric Administration (NOAA), industry and the research community. These technologies, currently in the initial stages of implementation by industry, will provide more precise and timely knowledge of the weather and enable pilots in flight to make decisions that result in safer and more efficient operations.

  15. EPR Severe Accident Threats and Mitigation

    SciTech Connect

    Azarian, G.; Kursawe, H.M.; Nie, M.; Fischer, M.; Eyink, J.; Stoudt, R.H.

    2004-07-01

    Despite the extremely low EPR core melt frequency, an improved defence-in-depth approach is applied in order to comply with the EPR safety target: no stringent countermeasures should be necessary outside the immediate plant vicinity like evacuation, relocation or food control other than the first harvest in case of a severe accident. Design provisions eliminate energetic events and maintain the containment integrity and leak-tightness during the entire course of the accident. Based on scenarios that cover a broad range of physical phenomena and which provide a sound envelope of boundary conditions associated with each containment challenge, a selection of representative loads has been done, for which mitigation measures have to cope with. This paper presents the main critical threats and the approach used to mitigate those threats. (authors)

  16. Lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of dacryocystorhinostomy

    PubMed Central

    Olaleye, Oladejo; Salleh, Shizalia; David, Don; Bickerton, Richard

    2013-01-01

    This was an unusual case of lacrimal sac compression by an anterior ethmoidal mucocele presenting as a late complication of a dacryocystorhinostomy (DCR) that was jointly managed by ophthalmic and ENT surgeons via an endoscopic approach. A 22-year-old lady presented with a 12-month history of a painless lump in her left medial canthus area and a 6-month history of left intermittent epiphora. She had a DCR when she was 15 years old with initial symptom control until recent recurrence. There were no nasal or other eye symptoms. The rest of the eye and nasendoscopic examinations were unremarkable. An MRI scan suggested a dacryocystocele; however, a further CT scan revealed a 1.6 cm cystic lesion consistent with an anterior ethmoidal mucocele compressing the lacrimal sac. An endoscopic left anterior ethmoidectomy with marsupialisation of the mucocele was performed in combination with an endoscopic DCR. She made good post-operative recovery. PMID:24964413

  17. Multi-level security for computer networking: SAC digital network approach

    SciTech Connect

    Griess, W.; Poutre, D.L.

    1983-10-01

    For telecommunications systems simultaneously handling data of different security levels, multilevel secure (MLS) operation permits maximum use of resources by automatically providing protection to users with various clearances and needs-to-know. The strategic air command (SAC) is upgrading the primary record data system used to command and control its strategic forces. The upgrade, called the SAC Digital Network (SACDIN), is designed to provide multilevel security to support users and external interfaces, with allowed accesses ranging from unclassified to top secret. SACDIN implements a security kernel based upon the Bell and Lapadula security model. This study presents an overview of the SACDIN security architecture and describes the basic message flow across the MLS network. 7 references.

  18. Air sac adenocarcinoma of the sternum in a Quaker parrot (Myiopsitta monachus).

    PubMed

    Loukopoulos, Panayiotis; Okuni, Julius Boniface; Micco, Teresa; Garcia, Jorge P; Uzal, Francisco A; Diab, Santiago S

    2014-12-01

    Respiratory neoplasia is rarely reported in avian species. A 17-yr-old Quaker parrot (Myiopsitta monachus) was admitted with a 2-wk history of anorexia, depression, and respiratory distress. Clinical examination revealed a large, firm mass in the left pectoral muscle. Radiology showed a mass silhouetting the heart and the liver. Supportive treatment was provided, but the bird died during the seventh weekly visit to drain thoracic cavity fluid. Necropsy showed a white, 3 x 3 x 2-cm, hard, gritty sternal mass. Histology showed a nonencapsulated, moderately differentiated air sac carcinoma of the sternum. Immunohistochemically the neoplasm was cytokeratin positive and vimentin and calretinin negative. This is the first report of an air sac neoplasia in a Quaker parrot and one of few respiratory tumors in psittacines.

  19. Development of SAC-OCDMA in FSO with multi-wavelength laser source

    NASA Astrophysics Data System (ADS)

    Moghaddasi, Majid; Mamdoohi, Ghazaleh; Muhammad Noor, Ahmad Shukri; Mahdi, Mohd Adzir; Ahmad Anas, Siti Barirah

    2015-12-01

    We propose and demonstrate a free space optical network, based on spectral amplitude coding optical code division multiple access (SAC-OCDMA) with a multi-wavelength laser source. A detailed theoretical analysis that represents the characteristics of SAC-OCDMA system was developed. In addition to the impact of turbulence, influences of several system noises such as optical beat interference (OBI), relative intensity noise, and receiver noises, have been studied. From the numerical results, it was found that the influence of OBI is more dominant, especially at higher received power. Two different codes, namely, modified quadratic congruence and modified double weight, are then compared with the latter which provides better performance. A transmission distance of 2.6 km with 10 users and an 8 cm aperture diameter is advisable whenever the turbulence is moderate. These results can be improved when a beam divergence smaller than 1 mrad is utilized.

  20. Multi-level security for computer networking - SAC digital network approach

    NASA Astrophysics Data System (ADS)

    Griess, W.; Poutre, D. L.

    The functional features and architecture of the SACDIN (SAC digital network) are detailed. SACDIN is the new data transmission segment for directing SAC's strategic forces. The system has 135 processor nodes at 32 locations and processes, distributes and stores data of any level of security classification. The sophistication of access nodes is dependent on the location. A reference monitor mediates the multilevel security by implementation of the multi-state machine concept, i.e., the Bell-LaPadula model (1973, 1974), which concludes that a secure state can never lead to an unsecure state. The monitor is controlled by the internal access control mechanism, which resides in PROM. Details of the access process are provided, including message flow on trusted paths appropriate to the security clearance of the user.

  1. A Rare Case of Endolymphatic Sac Tumour: Clinicopathologic Study and Surgical Management

    PubMed Central

    Ferri, Emanuele; Amadori, Maurizio; Armato, Enrico; Pavon, Ida

    2014-01-01

    Objective. Endolymphatic sac tumor (ELST) is a rare neoplasm arising from the intrapetrous portion of the endolymphatic sac, either isolated or in association with the von Hippel-Lindau disease. We report a sporadic case of ELST with an overview of the literature and a discussion of clinic-radiological, histopathologic, and surgical findings. Case Report. A young woman presented with a progressive hearing loss in the left ear. Otoscopy showed a reddish, bleeding hypotympanic mass. CT demonstrated an expansile lytic mastoid lesion extending to the middle ear, with bone erosion. MRI confirmed a lesion of increased signal on T1-weighted sequences. The patient underwent a canal wall-down tympanoplasty with complete removal of the tumor. Histopathology was consistent with a papillary ELST. Immunohistochemistry was positive for cytokeratin and chromogranin A. Conclusion. This paper highlights the rarity of ELST, the need for an accurate neuroradiological and immunohistochemical study at the early stages, and the timeliness of surgical treatment. PMID:24991442

  2. An analysis of accident data for franchised public buses in Hong Kong.

    PubMed

    Evans, W A; Courtney, A J

    1985-10-01

    This paper analyses data on accidents involving franchised public buses operating in Hong Kong. The data were obtained from the Royal Hong Kong Police, the Hong Kong Government Transport Department, the two major franchised bus operators and international sources. The analysis includes an international comparison of accidents with emphasis on the situation in Hong Kong compared to urban areas in the United Kingdom. An attempt has been made to identify the characteristics of bus accidents; accident incidence has been related to time of day, day of the week, time of year, weather conditions, driver's age and experience, hours on duty and policy-reported cause. The results indicate that Hong Kong has a high accident rate compared to Japan, the U.K. and the U.S.A., with particularly high pedestrian involvement rates. Bus accidents peak at around 9:00 AM and 4:00 PM but the accident rate is high throughout the day. Monday and Saturday appear to have a higher than average accident rate. The variability of accident rate throughout the year does not seem to be significant and the accident rate does not appear to be influenced by weather conditions. Older, more experienced drivers generally have a safer driving record than their younger, less experienced colleagues. Accident occurrence is related to the time the driver has been on duty. The paper questions the reliability of police-reported accident causation data and suggests improvements in the design of the accident report form and in the training of police investigators. The relevance of the Hong Kong study for accident research in general is also discussed.

  3. An analysis of accident data for franchised public buses in Hong Kong.

    PubMed

    Evans, W A; Courtney, A J

    1985-10-01

    This paper analyses data on accidents involving franchised public buses operating in Hong Kong. The data were obtained from the Royal Hong Kong Police, the Hong Kong Government Transport Department, the two major franchised bus operators and international sources. The analysis includes an international comparison of accidents with emphasis on the situation in Hong Kong compared to urban areas in the United Kingdom. An attempt has been made to identify the characteristics of bus accidents; accident incidence has been related to time of day, day of the week, time of year, weather conditions, driver's age and experience, hours on duty and policy-reported cause. The results indicate that Hong Kong has a high accident rate compared to Japan, the U.K. and the U.S.A., with particularly high pedestrian involvement rates. Bus accidents peak at around 9:00 AM and 4:00 PM but the accident rate is high throughout the day. Monday and Saturday appear to have a higher than average accident rate. The variability of accident rate throughout the year does not seem to be significant and the accident rate does not appear to be influenced by weather conditions. Older, more experienced drivers generally have a safer driving record than their younger, less experienced colleagues. Accident occurrence is related to the time the driver has been on duty. The paper questions the reliability of police-reported accident causation data and suggests improvements in the design of the accident report form and in the training of police investigators. The relevance of the Hong Kong study for accident research in general is also discussed. PMID:4096796

  4. Intrinsic Levanase Activity of Bacillus subtilis 168 Levansucrase (SacB).

    PubMed

    Méndez-Lorenzo, Luz; Porras-Domínguez, Jaime R; Raga-Carbajal, Enrique; Olvera, Clarita; Rodríguez-Alegría, Maria Elena; Carrillo-Nava, Ernesto; Costas, Miguel; López Munguía, Agustín

    2015-01-01

    Levansucrase catalyzes the synthesis of fructose polymers through the transfer of fructosyl units from sucrose to a growing fructan chain. Levanase activity of Bacillus subtilis levansucrase has been described since the very first publications dealing with the mechanism of levan synthesis. However, there is a lack of qualitative and quantitative evidence regarding the importance of the intrinsic levan hydrolysis of B. subtilis levansucrase and its role in the levan synthesis process. Particularly, little attention has been paid to the long-term hydrolysis products, including its participation in the final levan molecules distribution. Here, we explored the hydrolytic and transferase activity of the B. subtilis levansucrase (SacB) when levans produced by the same enzyme are used as substrate. We found that levan is hydrolyzed through a first order exo-type mechanism, which is limited to a conversion extent of around 30% when all polymer molecules reach a structure no longer suitable to SacB hydrolysis. To characterize the reaction, Isothermal Titration Calorimetry (ITC) was employed and the evolution of the hydrolysis products profile followed by HPLC, GPC and HPAEC-PAD. The ITC measurements revealed a second step, taking place at the end of the reaction, most probably resulting from disproportionation of accumulated fructo-oligosaccharides. As levanase, levansucrase may use levan as substrate and, through a fructosyl-enzyme complex, behave as a hydrolytic enzyme or as a transferase, as demonstrated when glucose and fructose are added as acceptors. These reactions result in a wide variety of oligosaccharides that are also suitable acceptors for fructo-oligosaccharide synthesis. Moreover, we demonstrate that SacB in the presence of levan and glucose, through blastose and sucrose synthesis, results in the same fructooligosaccharides profile as that observed in sucrose reactions. We conclude that SacB has an intrinsic levanase activity that contributes to the final

  5. Amines in the marking fluid and anal sac secretion of the tiger, Panthera tigris.

    PubMed

    Banks, G R; Buglass, A J; Waterhouse, J S

    1992-01-01

    Analysis of the marking fluid of two tigers (one Bengal and one Sumatran) by GC using an amine-specific column and a nitrogen-specific detector has shown the presence of the following amines: ammonia, methylamine, dimethylamine, trimethylamine, triethylamine, propylamine, and butane-1,4-diamine (putrescine). In contrast to previously published reports, we were unable to detect 2-phenylethylamine. The anal sac secretion was found to have a similar amine content.

  6. KNApSAcK Metabolite Activity Database for retrieving the relationships between metabolites and biological activities.

    PubMed

    Nakamura, Yukiko; Afendi, Farit Mochamad; Parvin, Aziza Kawsar; Ono, Naoaki; Tanaka, Ken; Hirai Morita, Aki; Sato, Tetsuo; Sugiura, Tadao; Altaf-Ul-Amin, Md; Kanaya, Shigehiko

    2014-01-01

    Databases (DBs) are required by various omics fields because the volume of molecular biology data is increasing rapidly. In this study, we provide instructions for users and describe the current status of our metabolite activity DB. To facilitate a comprehensive understanding of the interactions between the metabolites of organisms and the chemical-level contribution of metabolites to human health, we constructed a metabolite activity DB known as the KNApSAcK Metabolite Activity DB. It comprises 9,584 triplet relationships (metabolite-biological activity-target species), including 2,356 metabolites, 140 activity categories, 2,963 specific descriptions of biological activities and 778 target species. Approximately 46% of the activities described in the DB are related to chemical ecology, most of which are attributed to antimicrobial agents and plant growth regulators. The majority of the metabolites with antimicrobial activities are flavonoids and phenylpropanoids. The metabolites with plant growth regulatory effects include plant hormones. Over half of the DB contents are related to human health care and medicine. The five largest groups are toxins, anticancer agents, nervous system agents, cardiovascular agents and non-therapeutic agents, such as flavors and fragrances. The KNApSAcK Metabolite Activity DB is integrated within the KNApSAcK Family DBs to facilitate further systematized research in various omics fields, especially metabolomics, nutrigenomics and foodomics. The KNApSAcK Metabolite Activity DB could also be utilized for developing novel drugs and materials, as well as for identifying viable drug resources and other useful compounds.

  7. Intrinsic Levanase Activity of Bacillus subtilis 168 Levansucrase (SacB)

    PubMed Central

    Raga-Carbajal, Enrique; Olvera, Clarita; Rodríguez-Alegría, Maria Elena; Carrillo-Nava, Ernesto; Costas, Miguel; López Munguía, Agustín

    2015-01-01

    Levansucrase catalyzes the synthesis of fructose polymers through the transfer of fructosyl units from sucrose to a growing fructan chain. Levanase activity of Bacillus subtilis levansucrase has been described since the very first publications dealing with the mechanism of levan synthesis. However, there is a lack of qualitative and quantitative evidence regarding the importance of the intrinsic levan hydrolysis of B. subtilis levansucrase and its role in the levan synthesis process. Particularly, little attention has been paid to the long-term hydrolysis products, including its participation in the final levan molecules distribution. Here, we explored the hydrolytic and transferase activity of the B. subtilis levansucrase (SacB) when levans produced by the same enzyme are used as substrate. We found that levan is hydrolyzed through a first order exo-type mechanism, which is limited to a conversion extent of around 30% when all polymer molecules reach a structure no longer suitable to SacB hydrolysis. To characterize the reaction, Isothermal Titration Calorimetry (ITC) was employed and the evolution of the hydrolysis products profile followed by HPLC, GPC and HPAEC-PAD. The ITC measurements revealed a second step, taking place at the end of the reaction, most probably resulting from disproportionation of accumulated fructo-oligosaccharides. As levanase, levansucrase may use levan as substrate and, through a fructosyl-enzyme complex, behave as a hydrolytic enzyme or as a transferase, as demonstrated when glucose and fructose are added as acceptors. These reactions result in a wide variety of oligosaccharides that are also suitable acceptors for fructo-oligosaccharide synthesis. Moreover, we demonstrate that SacB in the presence of levan and glucose, through blastose and sucrose synthesis, results in the same fructooligosaccharides profile as that observed in sucrose reactions. We conclude that SacB has an intrinsic levanase activity that contributes to the final

  8. Amines in the marking fluid and anal sac secretion of the tiger, Panthera tigris.

    PubMed

    Banks, G R; Buglass, A J; Waterhouse, J S

    1992-01-01

    Analysis of the marking fluid of two tigers (one Bengal and one Sumatran) by GC using an amine-specific column and a nitrogen-specific detector has shown the presence of the following amines: ammonia, methylamine, dimethylamine, trimethylamine, triethylamine, propylamine, and butane-1,4-diamine (putrescine). In contrast to previously published reports, we were unable to detect 2-phenylethylamine. The anal sac secretion was found to have a similar amine content. PMID:1388518

  9. Computed tomographic epidurography: an aid to understanding deformation of the lumbar dural sac by epidural injections.

    PubMed

    Fukushige, T; Kano, T; Sano, T; Irie, M

    1999-09-01

    Local anaesthetics injected into the epidural space may deform the dural sac to a variable degree, thereby contributing to variability in the extent of the block. We investigated deformation of the lumbar dural sac after injection into the lumbar epidural space. The subjects were 26 patients with low-back pain who underwent lumbar epidurography and computed tomographic (CT) epidurography, of whom seven also underwent myelography and computed tomographic myelography. The epidural space was entered via the sacral hiatus in 24 patients and through the L5/S1 interspace in two patients. Ten millilitres of local anaesthetic was then injected into the epidural space followed by 20 mL of contrast medium. Computed tomographic epidurography was undertaken approximately 30-min after the epidural injection at the mid-vertebral and mid-discal levels from the first lumbar through to the first sacral vertebrae. The dural sac usually showed an oval or hexagonal shape on the transverse views at the first and second lumbar vertebral levels, and the shape of an inverted triangle below the level of the third lumbar vertebra. A median line of translucency was also observed on the posteroanterior epidurographic view in 25 of the 26 patients. This line was though to be a manifestation of the dural deformation to the inverted triangle. Dural sac deformation usually shows a specific pattern, although there are individual variations. Dural deformability is an important consideration in any analysis of the spread of epidural block or of the changes of epidural pressure after epidural injection of local anaesthetics. PMID:10549463

  10. Effect of alternative aging and accident simulations on polymer properties

    SciTech Connect

    Bustard, L.D.; Chenion, J.; Carlin, F.; Alba, C.; Gaussens, G.; LeMeur, M.

    1985-05-01

    The influence of accident irradiation, steam, and chemical spray exposures on the behavior of twenty-three age-preconditioned polymer sample sets (twenty-one different materials) has been investigated. The test program varied the following conditions: (1) Accident simulations of irradiation and thermodynamic (steam and chemical spray) conditions were performed both sequentially and simultaneously. (2) Accident thermodynamic (steam and chemical spray) exposures were performed both with and without air present during the exposures. (3) Sequential accident irradiations were performed both at 28/sup 0/C and 70/sup 0/C. (4) Age preconditioning was performed both sequentially and simultaneously. (5) Sequential aging irradiations were performed both at 27/sup 0/C and 70/sup 0/C. (6) Sequential aging exposures were performed using two sequences: (1) thermal followed by irradiation and (2) irradiation followed by thermal. We report both general trends applicable to a majority of the tested materials as well as specific results for each polymer. Our data base consists of ultimate tensile properties at the completion of the accident exposure for three XLPO and XLPE, five EPR and EPDM, two CSPE (HYPALON), one CPE, one VAMAC, one polydiallylphtalate, and one PPS material. We also report bend test results at completion of the accident exposures for two TEFZEL materials and permanent set after compression results for three EPR, one VAMAC, one BUNA N, one SILICONE, and one VITON material.

  11. Silver(I)-saccharin coordination polymers with 2-pyridylmethanol and 2,6-pyridinedimethanol. Synthetic, spectroscopic, thermal and structural studies of [Ag(sac)( μ-mpy)] n and [Ag( μ-sac)(dmpy)] n

    NASA Astrophysics Data System (ADS)

    Hamamci, Sevim; Yilmaz, Veysel T.; Harrison, William T. A.; Thöne, Carsten

    2005-04-01

    Two new coordination polymers of saccharinato-silver(I) complexes with 2-pyridylmethanol (mpy) and 2,6-pyridinedimethanol (dmpy), [Ag(sac)( μ-mpy)] n ( 1) and [Ag( μ-sac)(dmpy)] n ( 2), (sac = saccharinate), have been synthesized and structurally characterized by elemental analysis, IR, thermal analysis and single crystal X-ray diffraction. Crystal data: 1, monoclinic, P2/c, with a=13.3584(14) Å, b=8.3040(10) Å, c=13.0430(14) Å, β=106.227(3)°, Z=4; 2, monoclinic, P2/n, with a=7.3538(1) Å, b=13.0444(3) Å, c=15.7315(3) Å, β=98.8976(13)°, Z=4. In 1, [Ag 2(sac) 2(mpy) 2] building blocks are connected into a two-dimensional framework by bridging OH groups of mpy, and they are further stacked by O sbnd H⋯O hydrogen bonds, and weak π(sac)⋯ π(py) and π(py)⋯ π(py) interactions to form a three-dimensional supramolecular framework. In 2, [Ag 2(sac)(dmpy)] units are linked by the O sulfonyl bridges of sac, leading to one-dimensional polymeric chains, which are reinforced by the O sbnd H⋯O hydrogen bonds and π(sac)⋯ π(py) interactions to generate a three-dimensional supramolecular network. The coordination polymers 1 and 2 exhibit three- and four- coordinated silver(I) centers, respectively, and the intra-chain Ag⋯Ag separations in 1 and 2 are 3.2988(4) and 4.1429(2) Å, respectively.

  12. Characterization of calcium carbonate crystals in pigeon yolk sacs with different incubation times.

    PubMed

    Song, Juan; Cheng, Haixia; Shen, Xinyu; Hu, Jingxiao; Tong, Hua

    2014-05-01

    Calcium carbonate crystals are known to form in the yolk sacs of fertile pigeon eggs at late stages of incubation. The composition and structure of these crystals were investigated, the crystallization environment was inspected, and the physical chemistry constants of the yolk fluid were determined through the incubation period. Polarized light microscopy was used to observe the generation and distribution of calcium carbonate crystals in the yolk sac. In addition, X-ray diffraction was employed to analyze the composition and crystal phase of the yolk sac. A decalcification and deproteination method was established to analyze the ultrastructure and composition of the crystals, as well as the internal relationship between inorganic and organic phases of the crystals. Additionally, scanning electron microscopy, transmission electron microscopy, X-ray energy dispersive spectroscopy, and Fourier transform infrared spectroscopy were used to evaluate the characteristics of the crystals. Our results demonstrated that the calcium carbonate crystals were mainly composed of vaterite and calcite, with vaterite being the major component. Vaterite, a type of biomaterial generated by an organic template control, presented as a concentric hierarchical spherical structure. The organic nature of the biomaterial prevented vaterite from transforming into calcite, which is more thermodynamically stable than vaterite. Additionally, the configuration, size, and aggregation of vaterite were also mediated by the organic template. This bio-vaterite was found during the incubation period and is valuable in calcium transport during embryonic development.

  13. Pathological, immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis

    PubMed Central

    Amin, Rowayda Mahmoud; Hussein, Faten Aly; Idriss, Hisham Farouk; Hanafy, Nesrine Fathy; Abdallah, Dina Mohamed

    2013-01-01

    AIM To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial infection and can result in dacryocystitis, which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery. The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system. Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious, inflammatory, traumatic, mechanical, toxic or neoplastic causes mimicking idiopathic inflammation. These cases are treated by dacryocystorhinostomy (DCR). METHODS The present study was conducted to determine the histopathologic, immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy. RESULTS Non-specific lacrimal sac pathology was present in all 33 cases and 81.8% of the cases showed moderate chronic inflammation with a chronic inflammatory score (CIS) ranging between 4 and 6, whereas 12.12% showed severe inflammatory changes with a CIS of 7. Mild degree of inflammation was seen in 6.06% with a CIS of 3. The total prevalence of gram-positive, gram-negative, and culture-negative samples were 59.4%, 37.5%, and 3% respectively. CONCLUSION Non-specific chronic inflammation with fibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens. PMID:24392331

  14. Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation

    NASA Technical Reports Server (NTRS)

    Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

    2002-01-01

    The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

  15. Heterogeneity of vocal sac inflation patterns in Odorrana tormota plays a role in call diversity.

    PubMed

    Zhang, Fang; Zhao, Juan; Chen, Pan; Chen, Zhuqing; Chen, Yuanyuan; Feng, Albert S

    2016-03-01

    Male concave-eared torrent frogs (Odorrana tormota) can emit at least eight distinct call-types. However, the mechanisms by which they are produced are not fully understood. Anatomical analysis revealed that the vocal sacs of male O. tormota comprise two physically distinct compartments (pars lateralis and pars ventralis), residing on two sides of the vocal slits. The goal of the present study was to test the hypothesis that the two compartments play a role in the production of the diverse call-types. For this, audio and video recordings of male vocalizations were made, and sounds were analyzed afterwards. Results showed that the vocal sac inflation pattern was heterogeneous, and the call duration was a major factor determining the differential inflation patterns. Short call-types (duration <200 ms) involved inflation of one of the compartments only; those having a fundamental frequency (F0) of >5000 Hz involved inflation of pars lateralis only, whereas those with an F0 of <4000 Hz (tone-pips and "infant" calls) involved inflation of pars ventralis only. Long call-types (duration >200 ms), e.g., shallow frequency modulation calls, staccato calls, and long calls, involved inflation of both compartments of the vocal sacs. These results give support to the working hypothesis.

  16. A case of congenital diaphragmatic hernia with a hernia sac attached to the liver: hints for an early embryological insult.

    PubMed

    Sharma, Shilpa; Jain, Rani; Singh, M K; Gupta, Devendra K

    2007-10-01

    We describe here the unusual operative findings in a case of congenital diaphragmatic hernia (CDH). A neonate antenatally diagnosed as having CDH was operated via a left subcostal incision. The operative findings included a large central diaphragmatic defect of 5 x 5 cm, lined by a thick sac. The contents of the hernia included the stomach, spleen, and loops of the small and large intestine. The left side of the liver was thinned out and forming a part of the dome of the sac of the CDH. Vessels of the hepatic tissue were in continuity with the sac. There were scattered liver tissues forming cords in the sac lining. These findings were confirmed by histopathologic examinations. These findings have not been reported earlier in humans and might help to elucidate the embryology of the development of the diaphragm. Our findings suggest that this kind of defect occurs early in development, and we hypothesize that it is associated with a poorer prognosis.

  17. A review of criticality accidents

    SciTech Connect

    Stratton, W R; Smith, D R

    1989-03-01

    Criticality accidents and the characteristics of prompt power excursions are discussed. Forty-one accidental power transients are reviewed. In each case where available, enough detail is given to help visualize the physical situation, the cause or causes of the accident, the history and characteristics of the transient, the energy release, and the consequences, if any, to personnel and property. Excursions associated with large power reactors are not included in this study, except that some information on the major accident at the Chernobyl reactor in April 1986 is provided in the Appendix. 67 refs., 21 figs., 2 tabs.

  18. Preliminary analysis of loss-of-coolant accident in Fukushima nuclear accident

    SciTech Connect

    Su'ud, Zaki; Anshari, Rio

    2012-06-06

    Loss-of-Coolant Accident (LOCA) in Boiling Water Reactor (BWR) especially on Fukushima Nuclear Accident will be discussed in this paper. The Tohoku earthquake triggered the shutdown of nuclear power reactors at Fukushima Nuclear Power station. Though shutdown process has been completely performed, cooling process, at much smaller level than in normal operation, is needed to remove decay heat from the reactor core until the reactor reach cold-shutdown condition. If LOCA happen at this condition, it will cause the increase of reactor fuel and other core temperatures and can lead to reactor core meltdown and exposure of radioactive material to the environment such as in the Fukushima Dai Ichi nuclear accident case. In this study numerical simulation has been performed to calculate pressure composition, water level and temperature distribution on reactor during this accident. There are two coolant regulating system that operational on reactor unit 1 at this accident, Isolation Condensers (IC) system and Safety Relief Valves (SRV) system. Average mass flow of steam to the IC system in this event is 10 kg/s and could keep reactor core from uncovered about 3,2 hours and fully uncovered in 4,7 hours later. There are two coolant regulating system at operational on reactor unit 2, Reactor Core Isolation Condenser (RCIC) System and Safety Relief Valves (SRV). Average mass flow of coolant that correspond this event is 20 kg/s and could keep reactor core from uncovered about 73 hours and fully uncovered in 75 hours later. There are three coolant regulating system at operational on reactor unit 3, Reactor Core Isolation Condenser (RCIC) system, High Pressure Coolant Injection (HPCI) system and Safety Relief Valves (SRV). Average mass flow of water that correspond this event is 15 kg/s and could keep reactor core from uncovered about 37 hours and fully uncovered in 40 hours later.

  19. Preliminary analysis of loss-of-coolant accident in Fukushima nuclear accident

    NASA Astrophysics Data System (ADS)

    Su'ud, Zaki; Anshari, Rio

    2012-06-01

    Loss-of-Coolant Accident (LOCA) in Boiling Water Reactor (BWR) especially on Fukushima Nuclear Accident will be discussed in this paper. The Tohoku earthquake triggered the shutdown of nuclear power reactors at Fukushima Nuclear Power station. Though shutdown process has been completely performed, cooling process, at much smaller level than in normal operation, is needed to remove decay heat from the reactor core until the reactor reach cold-shutdown condition. If LOCA happen at this condition, it will cause the increase of reactor fuel and other core temperatures and can lead to reactor core meltdown and exposure of radioactive material to the environment such as in the Fukushima Dai Ichi nuclear accident case. In this study numerical simulation has been performed to calculate pressure composition, water level and temperature distribution on reactor during this accident. There are two coolant regulating system that operational on reactor unit 1 at this accident, Isolation Condensers (IC) system and Safety Relief Valves (SRV) system. Average mass flow of steam to the IC system in this event is 10 kg/s and could keep reactor core from uncovered about 3,2 hours and fully uncovered in 4,7 hours later. There are two coolant regulating system at operational on reactor unit 2, Reactor Core Isolation Condenser (RCIC) System and Safety Relief Valves (SRV). Average mass flow of coolant that correspond this event is 20 kg/s and could keep reactor core from uncovered about 73 hours and fully uncovered in 75 hours later. There are three coolant regulating system at operational on reactor unit 3, Reactor Core Isolation Condenser (RCIC) system, High Pressure Coolant Injection (HPCI) system and Safety Relief Valves (SRV). Average mass flow of water that correspond this event is 15 kg/s and could keep reactor core from uncovered about 37 hours and fully uncovered in 40 hours later.

  20. Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors.

    PubMed

    Gonzalez-Roibon, Nilda; Katz, Betina; Chaux, Alcides; Sharma, Rajni; Munari, Enrico; Faraj, Sheila F; Illei, Peter B; Torbenson, Michael; Netto, George J

    2013-07-01

    SALL4 is a transcription factor that serves as a marker of yolk sac tumor. Yolk sac tumor and hepatocellular carcinoma share histologic, serologic, and immunohistochemical features. Previous studies have shown lack of SALL4 expression in hepatocellular carcinoma, suggesting utility in this differential diagnosis. Sixty-nine samples of hepatocellular carcinoma were retrieved from surgical pathology archives and used to construct 9 tissue microarrays. A germ cell tumor tissue microarray containing 10 yolk sac tumors was used for comparison. Extent, intensity, and pattern of nuclear SALL4 expression were assessed in each spot. Mean percentage of expression was calculated for each tumor and used during analysis. Optimal discriminatory extent of expression cutoff was determined by receiver operating characteristic curve analysis. Other potential discriminatory markers including Hep Par1 were also evaluated. Forty-six percent (32/69) of hepatocellular carcinoma and all yolk sac tumors revealed at least focal expression of SALL4. A unique punctuate/clumped pattern of nuclear staining was present in 94% (30/32) of hepatocellular carcinoma, whereas all yolk sac tumors displayed a diffuse finely granular nuclear staining pattern. A 25% extent of SALL4 expression cutoff was found to be optimal for the distinction of yolk sac tumor from hepatocellular carcinoma yielding a sensitivity of 100%, specificity of 92.8%, and a positive predictive value of 66.6% for yolk sac tumor diagnosis. The addition of Hep Par1 increased the specificity (99%) and positive predictive value (90%). This is the first report of SALL4 expression in hepatocellular carcinoma. Our finding should be taken into consideration in the differential diagnosis of hepatocellular carcinoma and yolk sac tumor. The unique punctuate/clumped pattern seen in hepatocellular carcinoma cases could be of further discriminatory value. PMID:23347651

  1. [Prevention of bicycle accidents].

    PubMed

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  2. [Prevention of bicycle accidents].

    PubMed

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  3. Ultrastructure of the endolymphatic sac in the larva of the japanese red-bellied newt Cynops pyrrhogaster

    NASA Technical Reports Server (NTRS)

    Gao, W.; Wiederhold, M.; Hejl, R.

    1998-01-01

    The ultrastructure of the endolymphatic sac (ES) of the late stage larva of the Japanese red-bellied newt, Cynops pyrrhogaster (stage 57), was examined by light and transmission electron microscopy. The two endolymphatic sacs are located at the dorsal-medial side of the otic vesicle on the dorsal-lateral side of the midbrain in the cranial cavity. The wall of the sac is composed of a layer of cubical epithelial cells with loose, interposed intercellular spaces. The sac contains a large luminal cavity, in which endolymph and numerous otoconia are present. The epithelial cells of different portions of the sac have a similar structure. These cells contain an abundance of cytoplasmic organelles, including ribosomes, Golgi complexes, and numerous vesicles. Two types of vesicles are found in the epithelial cells: the "floccular" vesicle and the "granular" vesicle. The floccular vesicles are located in the supra- and lateral-nuclear cytoplasm and contain floccular material. The granular vesicles have a fine granular substance and are usually situated apposed to the apical cell membrane. The granular vesicles are suggested to be secreted into the lumen, while the floccular vesicles are thought to be absorbed from the lumen and conveyed to the intercellular spaces by the epithelial cells. The apical surfaces of the epithelial cells bear numerous microvilli. Apparently floating cells, which bear long microvilli on the free surfaces, are observed in the lumen of the ES. Based on the fine structure, the function of the endolymphatic sac of the newt Cynops pyrrhogaster is discussed.

  4. Physiological requirements for 20-hydroxyecdysone-induced rectal sac distention in the pupa of the silkworm, Bombyx mori.

    PubMed

    Suzuki, Takumi; Sakurai, Sho; Iwami, Masafumi

    2010-06-01

    Successful insect development is achieved via appropriate fluctuation of ecdysteroid levels. When an insect's ecdysteroid level is disrupted, physiological and developmental defects occur. In the pupa of the silkworm, Bombyx mori, the rectal sac is an essential organ that operates as a repository for degraded ecdysteroids, and it can be distended by administration of 20-hydroxyecdysone (20E). Our previous study showed that rectal sac distention appears 4 days after 20E administration. Hemolymph ecdysteroid levels, however, decrease to lower level during this period. Thus, the timing of the rectal sac distention does not match with that of ecdysteroid elevation. Here, we examine how 20E induces rectal sac distention. A ligature experiment and ecdysteroid quantification showed that continuous 20E stimulation induces rectal sac distention. Thorax tissue contributed to the continuous 20E stimulation needed to induce distention. Ecdysteroid released from the thorax tissue may be converted to 20E by ecdysone 20-hydroxylase to produce continuous 20E stimulation. Thus, the ecdysone metabolic pathway plays a critical role in rectal sac distention.

  5. Transcript profiles of maize embryo sacs and preliminary identification of genes involved in the embryo sac–pollen tube interaction

    PubMed Central

    Wang, Shuai Shuai; Wang, Fang; Tan, Su Jian; Wang, Ming Xiu; Sui, Na; Zhang, Xian Sheng

    2014-01-01

    The embryo sac, the female gametophyte of flowering plants, plays important roles in the pollination and fertilization process. Maize (Zea mays L.) is a model monocot, but little is known about the interactions between its embryo sac and the pollen tube. In this study, we compared the transcript profiles of mature embryo sacs, mature embryo sacs 14–16 h after pollination, and mature nucelli. Comparing the transcript profiles of the embryo sacs before and after the entry of the pollen tube, we identified 3467 differentially expressed transcripts (3382 differentially expressed genes; DEGs). The DEGs were grouped into 22 functional categories. Among the DEGs, 221 genes were induced upon the entry of the pollen tube, and many of them encoded proteins involved in RNA binding, processing, and transcription, signaling, miscellaneous enzyme family processes, and lipid metabolism processes. Genes in the DEG dataset were grouped into 17 classes in a gene ontology enrichment analysis. The DEGs included many genes encoding proteins involved in protein amino acid phosphorylation and protein ubiquitination, implying that these processes might play important roles in the embryo sac–pollen tube interaction. Additionally, our analyses indicate that the expression of 112 genes encoding cysteine-rich proteins (CRPs) is induced during pollination and fertilization. The CRPs likely regulate pollen tube guidance and embryo sac development. These results provide important information on the genes involved in the embryo sac–pollen tube interaction in maize. PMID:25566277

  6. Influencing Factors for Abdominal Aortic Aneurysm Sac Shrinkage and Enlargement after EVAR: Clinical Reviews before Introduction of Preoperative Coil Embolization

    PubMed Central

    Hiraoka, Arudo; Totsugawa, Toshinori; Tamura, Kentaro; Ishida, Atsuhisa; Sakaguchi, Taichi; Yoshitaka, Hidenori

    2014-01-01

    Background: We previously reported effectiveness of coil embolization (CE) to aortic branched vessels before endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) because of significant shrinkage of aneurysmal sac. In this study, we investigated EVAR cases to clarify influential factors of aneurysmal shrinkage and enlargement. Methods: 148 consecutive cases before the introduction of CE were retrospectively reviewed based on the presence of PT2EL (persistent type 2 endoleak) and change in sac diameter after EVAR by multivariate analysis. Results: (A) PT2EL risk factors were patent inferior mesenteric artery (IMA) and thinner mural thrombus inside aneurysmal sac. (B) Sac enlargement risk factors were antiplatelet intake, PT2EL, and female gender. (C) Sac shrinkage predictive factors were the absences of thoracic aortic aneurysm, antiplatelet intake, PT2EL, and coronary artery disease. Conclusion: CE to IMA was considered to be effective because patent IMA and antiplatelet intake were significant risk factors for sac enlargement. So, more meticulous therapeutic strategy, including treatment priority (AAA first or CAD first) and choice of treatment (EVAR vs. AAA) based on anatomical features of AAA was required to improve late outcomes. PMID:25298830

  7. β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.

    PubMed

    Fujita, Atsushi; Uchida, Naoya; Haro-Mora, Juan J; Winkler, Thomas; Tisdale, John

    2016-06-01

    Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a potential alternative source for red blood cell transfusion. However, when using traditional methods with embryoid bodies, ES cell-derived erythroid cells predominantly express embryonic type ɛ-globin, with lesser fetal type γ-globin and very little adult type β-globin. Furthermore, no β-globin expression is detected in iPS cell-derived erythroid cells. ES cell-derived sacs (ES sacs) have been recently used to generate functional platelets. Due to its unique structure, we hypothesized that ES sacs serve as hemangioblast-like progenitors capable to generate definitive erythroid cells that express β-globin. With our ES sac-derived erythroid differentiation protocol, we obtained ∼120 erythroid cells per single ES cell. Both primitive (ɛ-globin expressing) and definitive (γ- and β-globin expressing) erythroid cells were generated from not only ES cells but also iPS cells. Primitive erythropoiesis is gradually switched to definitive erythropoiesis during prolonged ES sac maturation, concurrent with the emergence of hematopoietic progenitor cells. Primitive and definitive erythroid progenitor cells were selected on the basis of glycophorin A or CD34 expression from cells within the ES sacs before erythroid differentiation. This selection and differentiation strategy represents an important step toward the development of in vitro erythroid cell production systems from pluripotent stem cells. Further optimization to improve expansion should be required for clinical application. Stem Cells 2016;34:1541-1552.

  8. Penguin lungs and air sacs: implications for baroprotection, oxygen stores and buoyancy.

    PubMed

    Ponganis, P J; St Leger, J; Scadeng, M

    2015-03-01

    The anatomy and volume of the penguin respiratory system contribute significantly to pulmonary baroprotection, the body O2 store, buoyancy and hence the overall diving physiology of penguins. Therefore, three-dimensional reconstructions from computerized tomographic (CT) scans of live penguins were utilized to measure lung volumes, air sac volumes, tracheobronchial volumes and total body volumes at different inflation pressures in three species with different dive capacities [Adélie (Pygoscelis adeliae), king (Aptenodytes patagonicus) and emperor (A. forsteri) penguins]. Lung volumes scaled to body mass according to published avian allometrics. Air sac volumes at 30 cm H2O (2.94 kPa) inflation pressure, the assumed maximum volume possible prior to deep dives, were two to three times allometric air sac predictions and also two to three times previously determined end-of-dive total air volumes. Although it is unknown whether penguins inhale to such high volumes prior to dives, these values were supported by (a) body density/buoyancy calculations, (b) prior air volume measurements in free-diving ducks and (c) previous suggestions that penguins may exhale air prior to the final portions of deep dives. Based upon air capillary volumes, parabronchial volumes and tracheobronchial volumes estimated from the measured lung/airway volumes and the only available morphometry study of a penguin lung, the presumed maximum air sac volumes resulted in air sac volume to air capillary/parabronchial/tracheobronchial volume ratios that were not large enough to prevent barotrauma to the non-collapsing, rigid air capillaries during the deepest dives of all three species, and during many routine dives of king and emperor penguins. We conclude that volume reduction of airways and lung air spaces, via compression, constriction or blood engorgement, must occur to provide pulmonary baroprotection at depth. It is also possible that relative air capillary and parabronchial volumes are

  9. Penguin lungs and air sacs: implications for baroprotection, oxygen stores and buoyancy.

    PubMed

    Ponganis, P J; St Leger, J; Scadeng, M

    2015-03-01

    The anatomy and volume of the penguin respiratory system contribute significantly to pulmonary baroprotection, the body O2 store, buoyancy and hence the overall diving physiology of penguins. Therefore, three-dimensional reconstructions from computerized tomographic (CT) scans of live penguins were utilized to measure lung volumes, air sac volumes, tracheobronchial volumes and total body volumes at different inflation pressures in three species with different dive capacities [Adélie (Pygoscelis adeliae), king (Aptenodytes patagonicus) and emperor (A. forsteri) penguins]. Lung volumes scaled to body mass according to published avian allometrics. Air sac volumes at 30 cm H2O (2.94 kPa) inflation pressure, the assumed maximum volume possible prior to deep dives, were two to three times allometric air sac predictions and also two to three times previously determined end-of-dive total air volumes. Although it is unknown whether penguins inhale to such high volumes prior to dives, these values were supported by (a) body density/buoyancy calculations, (b) prior air volume measurements in free-diving ducks and (c) previous suggestions that penguins may exhale air prior to the final portions of deep dives. Based upon air capillary volumes, parabronchial volumes and tracheobronchial volumes estimated from the measured lung/airway volumes and the only available morphometry study of a penguin lung, the presumed maximum air sac volumes resulted in air sac volume to air capillary/parabronchial/tracheobronchial volume ratios that were not large enough to prevent barotrauma to the non-collapsing, rigid air capillaries during the deepest dives of all three species, and during many routine dives of king and emperor penguins. We conclude that volume reduction of airways and lung air spaces, via compression, constriction or blood engorgement, must occur to provide pulmonary baroprotection at depth. It is also possible that relative air capillary and parabronchial volumes are

  10. Chemical Stockpile Disposal Program rapid accident assessment

    SciTech Connect

    Chester, C.V.

    1990-08-01

    This report develops a scheme for the rapid assessment of a release of toxic chemicals resulting from an accident in one of the most chemical weapon demilitarization plants or storage areas. The system uses such inputs as chemical and pressure sensors monitoring the plant and reports of accidents radioed to the Emergency Operations Center by work parties or monitoring personnel. A size of release can be estimated from previous calculations done in the risk analysis, from back calculation from an open-air chemical sensor measurement, or from an estimated percentage of the inventory of agent at the location of the release. Potential consequences of the estimated release are calculated from real-time meteorological data, surrounding population data, and properties of the agent. In addition to the estimated casualties, area coverage and no-death contours vs time would be calculated. Accidents are assigned to one of four categories: community emergencies, which are involve a threat to off-site personnel; on-post emergencies, which involve a threat only to on-site personnel; advisory, which involves a potential for threat to on-site personnel; and chemical occurrence, which can produce an abnormal operating condition for the plant but no immediate threat to on-site personnel. 9 refs., 20 tabs.

  11. [Orofacial injuries in skateboard accidents].

    PubMed

    Frohberg, U; Bonsmann, M

    1992-04-01

    In a clinical study, 25 accidents involving injuries by a fall with a skateboard were investigated and classified in respect of epidemiology, accident mechanism and injury patterns in the facial region. Accident victims are predominantly boys between 7 and 9 years of age. A multiple trauma involving the teeth and the dental system in general and the soft parts of the face is defined as a characteristic orofacial injury pattern in skateboard accidents. The high proportion of damage to the front teeth poses problems of functional and aesthetic rehabilitation necessitating long-term treatment courses in children and adolescents. Effective prevention of facial injuries may be possible by evolving better facial protection systems and by creating areas of playgrounds where skateboarders can practise safely.

  12. Aircraft accidents : method of analysis

    NASA Technical Reports Server (NTRS)

    1929-01-01

    This report on a method of analysis of aircraft accidents has been prepared by a special committee on the nomenclature, subdivision, and classification of aircraft accidents organized by the National Advisory Committee for Aeronautics in response to a request dated February 18, 1928, from the Air Coordination Committee consisting of the Assistant Secretaries for Aeronautics in the Departments of War, Navy, and Commerce. The work was undertaken in recognition of the difficulty of drawing correct conclusions from efforts to analyze and compare reports of aircraft accidents prepared by different organizations using different classifications and definitions. The air coordination committee's request was made "in order that practices used may henceforth conform to a standard and be universally comparable." the purpose of the special committee therefore was to prepare a basis for the classification and comparison of aircraft accidents, both civil and military. (author)

  13. Vehicle accidents related to sleep: a review

    PubMed Central

    Horne, J.; Reyner, L.

    1999-01-01

    Falling asleep while driving accounts for a considerable proportion of vehicle accidents under monotonous driving conditions. Many of these accidents are related to work--for example, drivers of lorries, goods vehicles, and company cars. Time of day (circadian) effects are profound, with sleepiness being particularly evident during night shift work, and driving home afterwards. Circadian factors are as important in determining driver sleepiness as is the duration of the drive, but only duration of the drive is built into legislation protecting professional drivers. Older drivers are also vulnerable to sleepiness in the mid-afternoon. Possible pathological causes of driver sleepiness are discussed, but there is little evidence that this factor contributes greatly to the accident statistics. Sleep does not occur spontaneously without warning. Drivers falling asleep are unlikely to recollect having done so, but will be aware of the precursory state of increasing sleepiness; probably reaching a state of fighting off sleep before an accident. Self awareness of sleepiness is a better method for alerting the driver than automatic sleepiness detectors in the vehicle. None of these have been proved to be reliable and most have shortcomings. Putative counter measures to sleepiness, adopted during continued driving (cold air, use of car radio) are only effective for a short time. The only safe counter measure to driver sleepiness, particularly when the driver reaches the stage of fighting sleep, is to stop driving, and--for example, take a 30 minute break encompassing a short (< 15 minute) nap or coffee (about 150 mg caffeine), which are very effective particularly if taken together. Exercise is of little use. CONCLUSIONS: More education of employers and employees is needed about planning journeys, the dangers of driving while sleepy, and driving at vulnerable times of the day.   PMID:10472301

  14. Spine Immobilizer for Accident Victims

    NASA Technical Reports Server (NTRS)

    Vykukal, H. C.; Lampson, K.

    1983-01-01

    Proposed conformal bladder filled with tiny spheres called "microballoons," enables spine of accident victim to be rapidly immobilized and restrained and permit victim to be safely removed from accident scene in extremely short time after help arrives. Microballoons expand to form rigid mass when pressure within bladder is less than ambient. Bladder strapped to victim is also strapped to rescue chair. Void between bladder and chair is filled with cloth wedges.

  15. Nuclear fuel cycle facility accident analysis handbook

    SciTech Connect

    Ayer, J E; Clark, A T; Loysen, P; Ballinger, M Y; Mishima, J; Owczarski, P C; Gregory, W S; Nichols, B D

    1988-05-01

    The Accident Analysis Handbook (AAH) covers four generic facilities: fuel manufacturing, fuel reprocessing, waste storage/solidification, and spent fuel storage; and six accident types: fire, explosion, tornado, criticality, spill, and equipment failure. These are the accident types considered to make major contributions to the radiological risk from accidents in nuclear fuel cycle facility operations. The AAH will enable the user to calculate source term releases from accident scenarios manually or by computer. A major feature of the AAH is development of accident sample problems to provide input to source term analysis methods and transport computer codes. Sample problems and illustrative examples for different accident types are included in the AAH.

  16. Psychological Distress and Post-Traumatic Symptoms Following Occupational Accidents

    PubMed Central

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O.; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-01-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers. PMID:25379258

  17. Psychological distress and post-traumatic symptoms following occupational accidents.

    PubMed

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-12-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers.

  18. OFFSITE RADIOLOGICAL CONSEQUENCE ANALYSIS FOR THE BOUNDING FLAMMABLE GAS ACCIDENT

    SciTech Connect

    KRIPPS, L.J.

    2005-02-18

    This document quantifies the offsite radiological consequences of the bounding flammable gas accident for comparison with the 25 rem Evaluation Guideline established in DOE-STD-3009, Appendix A. The bounding flammable gas accident is a detonation in a SST. The calculation applies reasonably conservative input parameters in accordance with guidance in DOE-STD-3009, Appendix A. The purpose of this analysis is to calculate the offsite radiological consequence of the bounding flammable gas accident. DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', requires the formal quantification of a limited subset of accidents representing a complete set of bounding conditions. The results of these analyses are then evaluated to determine if they challenge the DOE-STD-3009-94, Appendix A, ''Evaluation Guideline,'' of 25 rem total effective dose equivalent in order to identify and evaluate safety-class structures, systems, and components. The bounding flammable gas accident is a detonation in a single-shell tank (SST). A detonation versus a deflagration was selected for analysis because the faster flame speed of a detonation can potentially result in a larger release of respirable material. A detonation in an SST versus a double-shell tank (DST) was selected as the bounding accident because the estimated respirable release masses are the same and because the doses per unit quantity of waste inhaled are greater for SSTs than for DSTs. Appendix A contains a DST analysis for comparison purposes.

  19. Psychological distress and post-traumatic symptoms following occupational accidents.

    PubMed

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-12-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers. PMID:25379258

  20. Severe accidents due to windsurfing in the Aegean Sea.

    PubMed

    Kalogeromitros, A; Tsangaris, H; Bilalis, D; Karabinis, A

    2002-06-01

    Windsurfing is a popular sport and has recently become an Olympic event. As an open-air water activity that requires the participant to be in perfect physical condition, windsurfers may be prone to accidents when certain basic rules or procedures are violated. The current study monitored severe injuries due to windsurfing over a period of 12 months in the Aegean Sea in Greece. Our study revealed 22 cases of severe accidents due to windsurfing, with a wide range of injuries including head injuries, spinal cord injuries, and severe fractures of the extremities. Prolonged hospitalization, severe disability and two deaths occurred as consequences of these accidents. The study examined the characteristics of these patients and the possible risk factors and conditions associated with the accidents. We also focused on the most common types of injuries and reviewed the mechanisms that may provoke them. Water sports and particularly windsurfing represent a major challenge for the emergency medical system, especially in the Aegean Sea. Hundreds of islands, kilometres of isolated coasts, millions of tourists, an extended summer period and rapidly changing weather create conditions that constantly test the efficacy of the emergency services. The development of an appropriate infrastructure and maximum control of the risk factors causing these accidents could reduce the morbidity and mortality that, unfortunately but rather predictably, accompany this popular summer activity. PMID:12131638

  1. [Road vehicle accidents during travel and their prevention].

    PubMed

    Murat, J E

    1997-01-01

    The number of road vehicle accidents during travel outside Europe and/or under difficult conditions increases about 5% every year. Road accidents account for a third to half of medical evacuations as well as for the most serious injuries. The risk of accidents and their potential gravity may be enhanced by the poor condition of roads and vehicles. Personal factors including fatigue, speed, alcohol, drugs, and poor vision also play a major role. Physicians should warn travelers planning road trips of all these hazards and of any specific local conditions prevailing in certain destinations. Prevention depends on the age of the traveler and on any disabilities that he/she might have. Packing a first aid kit and inspecting safety equipment before the trip and at regular intervals during the trip are indispensable. Knowledge of emergency first aid procedures is highly recommendable. While avoiding excessiveness of any kind, the physician should encourage suitable psychological and material preparation in function of travel plans. This preparation should be aimed at reducing the risk of road accident particularly in developing countries. Counseling can be useful in reducing the risk of road accidents particularly in developing countries.

  2. Aspects Concerning The Rules And The Investigation Of Traffic Accidents As Work Accidents

    NASA Astrophysics Data System (ADS)

    Tarnu, Lucian Ioan

    2015-07-01

    When Romania joined the European Union, it was imposed that the Romanian legislation in the field of the security and health at work be in line with the European one. The concept of health as it is defined by the International Body of Health, refers to a good physical, mental and social condition. The improvement of the activity of preventing the traffic accidents as work accidents must have as basis the correct and accurate evaluation of risks of getting injured. The goal of the activity of prevention and protection is to ensure the best working conditions, the prevention of accidents and occupational diseases and the adjustment to the scientific and technological progress. In the road transport sector, as in any other sector, it is very important to pay attention to working conditions to ensure a workforce motivated and well qualified. Some features make it a more difficult sector risk management than other sectors. However, if one takes into account how it works in practice this sector and the characteristics of drivers and how they work routinely, risks, dangers and threats can be managed efficiently and with great success.

  3. Accident Tolerant Fuel Analysis

    SciTech Connect

    Curtis Smith; Heather Chichester; Jesse Johns; Melissa Teague; Michael Tonks; Robert Youngblood

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced “RISMC toolkit” that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional “accident-tolerant” (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and

  4. [Accidents of fulguration].

    PubMed

    Virenque, C; Laguerre, J

    1976-01-01

    Fulguration, first electric accident in which the man was a victim, is to day better known. A clap of thunder is decomposed in two elements: lightning, and thunder. Lightning is caused by an electrical discharge, either within a cloud, or between two clouds, or, above all, between a cloud and the surface of the ground. Experimental equipments owned by the French Electricity Company and by the Atomic Energy Commission, have allowed to photograph lightnings and to measure certain physical characteristics (Intensity variable between 25 to 100 kA, voltage variable between 20 to 1 000 kV). The frequency of storms was learned: the isokeraunic level, in France, is about 20, meaning that thunder is heard twenty days during one year. Man may be stricken by thunder by direct hit, by sudden bursting, by earth current, or through various conductors. The electric charge which reached him may go to the earth directly by contact with the ground or may dissipate in the air through a bony promontory (elbow). The total number of victims, "wounded" or deceased, is not now known by statistics. Death comes by insulation breakdown of one of several anatomic cephalic formations: skull, meninx, brain. Many various lesions may happen in survivors: loss of consciousness, more or less long, sensorial or motion deficiencies. All these signs are momentary and generally reversible. Besides one may observe much more intense lesions on the skin: burns and, over all, characteristic aborescence (skin effect by high frequency current). The heart is protected, contrarily to what happens with industrial electrocution. The curative treatment is merely symptomatic : reanimation, surgery for burns or associated traumatic lesions. A prevention is researched to help the lonely man, in the country or in the mountains in the houses (lightning conductor, Faraday cage), in vehicles (aircraft, cars, ships). The mysterious and unforseeable character of lightning still stays, leaving a door opened for numerous

  5. Accident tolerant fuel analysis

    SciTech Connect

    Smith, Curtis; Chichester, Heather; Johns, Jesse; Teague, Melissa; Tonks, Michael Idaho National Laboratory; Youngblood, Robert

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced ''RISMC toolkit'' that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional ''accident-tolerant'' (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and

  6. Quantifying safety benefit of winter road maintenance: accident frequency modeling.

    PubMed

    Usman, Taimur; Fu, Liping; Miranda-Moreno, Luis F

    2010-11-01

    This research presents a modeling approach to investigate the association of the accident frequency during a snow storm event with road surface conditions, visibility and other influencing factors controlling for traffic exposure. The results have the premise to be applied for evaluating different maintenance strategies using safety as a performance measure. As part of this approach, this research introduces a road surface condition index as a surrogate measure of the commonly used friction measure to capture different road surface conditions. Data from various data sources, such as weather, road condition observations, traffic counts and accidents, are integrated and used to test three event-based models including the Negative Binomial model, the generalized NB model and the zero inflated NB model. These models are compared for their capability to explain differences in accident frequencies between individual snow storms. It was found that the generalized NB model best fits the data, and is most capable of capturing heterogeneity other than excess zeros. Among the main results, it was found that the road surface condition index was statistically significant influencing the accident occurrence. This research is the first showing the empirical relationship between safety and road surface conditions at a disaggregate level (event-based), making it feasible to quantify the safety benefits of alternative maintenance goals and methods.

  7. A study of carburetor/induction system icing in general aviation accidents

    NASA Technical Reports Server (NTRS)

    Obermayer, R. W.; Roe, W. T.

    1975-01-01

    An assessment of the frequency and severity of carburetor/induction icing in general-aviation accidents was performed. The available literature and accident data from the National Transportation Safety Board were collected. A computer analysis of the accident data was performed. Between 65 and 90 accidents each year involve carburetor/induction system icing as a probable cause/factor. Under conditions conducive to carburetor/induction icing, between 50 and 70 percent of engine malfunction/failure accidents (exclusive of those due to fuel exhaustion) are due to carburetor/induction system icing. Since the evidence of such icing may not remain long after an accident, it is probable that the frequency of occurrence of such accidents is underestimated; therefore, some extrapolation of the data was conducted. The problem of carburetor/induction system icing is particularly acute for pilots with less than 1000 hours of total flying time. The severity of such accidents is about the same as any accident resulting from a forced landing or precautionary landing. About 144 persons, on the average, are exposed to death and injury each year in accidents involving carburetor/induction icing as a probable cause/factor.

  8. Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)

    SciTech Connect

    Ostrow, Lyle W.; Suchyna, Thomas M.; Sachs, Frederick

    2011-06-24

    Highlights: {yields} Endothelin-1 expression by adult rat astrocytes correlates with cell proliferation. {yields} Stretch-induced ET-1 is inhibited by GsMtx-4, a specific inhibitor of Ca{sup 2+} permeant SACs. {yields} The less specific SAC inhibitor streptomycin also inhibits ET-1 secretion. {yields} Stretch-induced ET-1 production depends on a calcium influx. {yields} SAC pharmacology may provide a new class of therapeutic agents for CNS pathology. -- Abstract: The expression of endothelins (ETs) and ET-receptors is often upregulated in brain pathology. ET-1, a potent vasoconstrictor, also inhibits the expression of astrocyte glutamate transporters and is mitogenic for astrocytes, glioma cells, neurons, and brain capillary endothelia. We have previously shown that mechanical stress stimulates ET-1 production by adult rat astrocytes. We now show in adult astrocytes that ET-1 production is driven by calcium influx through stretch-activated ion channels (SACs) and the ET-1 production correlates with cell proliferation. Mechanical stimulation using biaxial stretch (<20%) of a rubber substrate increased ET-1 secretion, and 4 {mu}M GsMTx-4 (a specific inhibitor of SACs) inhibited secretion by 30%. GsMTx-4 did not alter basal ET-1 levels in the absence of stretch. Decreasing the calcium influx by lowering extracellular calcium also inhibited stretch-induced ET-1 secretion without effecting ET-1 secretion in unstretched controls. Furthermore, inhibiting SACs with the less specific inhibitor streptomycin also inhibited stretch-induced ET-1 secretion. The data can be explained with a simple model in which ET-1 secretion depends on an internal Ca{sup 2+} threshold. This coupling of mechanical stress to the astrocyte endothelin system through SACs has treatment implications, since all pathology deforms the surrounding parenchyma.

  9. Implications for accident management of adding water to a degrading reactor core

    SciTech Connect

    Kuan, P.; Hanson, D.J.; Pafford, D.J.; Quick, K.S.; Witt, R.J.

    1994-02-01

    This report evaluates both the positive and negative consequences of adding water to a degraded reactor core during a severe accident. The evaluation discusses the earliest possible stage at which an accident can be terminated and how plant personnel can best respond to undesired results. Specifically discussed are (a) the potential for plant personnel to add water for a range of severe accidents, (b) the time available for plant personnel to act, (c) possible plant responses to water added during the various stages of core degradation, (d) plant instrumentation available to understand the core condition and (e) the expected response of the instrumentation during the various stages of severe accidents.

  10. The acid-induced folded state of Sac7d is the native state.

    PubMed Central

    Bedell, J. L.; McCrary, B. S.; Edmondson, S. P.; Shriver, J. W.

    2000-01-01

    Sac7d unfolds at low pH in the absence of salt, with the greatest extent of unfolding obtained at pH 2. We have previously shown that the acid unfolded protein is induced to refold by decreasing the pH to 0 or by addition of salt (McCrary BS, Bedell J. Edmondson SP, Shriver JW, 1998, J Mol Biol 276:203-224). Both near-ultraviolet circular dichroism spectra and ANS fluorescence enhancements indicate that the acid- and salt-induced folded states have a native fold and are not molten globular. 1H,15N heteronuclear single quantum coherence NMR spectra confirm that the native, acid-, and salt-induced folded states are essentially identical. The most significant differences in amide 1H and 15N chemical shifts are attributed to hydrogen bonding to titrating carboxyl side chains and through-bond inductive effects. The 1H NMR chemical shifts of protons affected by ring currents in the hydrophobic core of the acid- and salt-induced folded states are identical to those observed in the native. The radius of gyration of the acid-induced folded state at pH 0 is shown to be identical to that of the native state at pH 7 by small angle X-ray scattering. We conclude that acid-induced collapse of Sac7d does not lead to a molten globule but proceeds directly to the native state. The folding of Sac7d as a function of pH and anion concentration is summarized with a phase diagram that is similar to those observed for other proteins that undergo acid-induced folding except that the A-state is encompassed by the native state. These results demonstrate that formation of a molten globule is not a general property of proteins that are refolded by acid. PMID:11106160

  11. Yolk sac mesenchymal progenitor cells from New World mice (Necromys lasiurus) with multipotent differential potential.

    PubMed

    Favaron, Phelipe Oliveira; Mess, Andrea; Will, Sônia Elisabete; Maiorka, Paulo César; de Oliveira, Moacir Franco; Miglino, Maria Angelica

    2014-01-01

    Fetal membranes are abundant, ethically acceptable and readily accessible sources of stem cells. In particular, the yolk sac is a source of cell lineages that do not express MHCs and are mainly free from immunological incompatibles when transferred to a recipient. Although data are available especially for hematopoietic stem cells in mice and human, whereas other cell types and species are dramatically underrepresented. Here we studied the nature and differentiation potential of yolk sac derived mesenchymal stem cells from a New World mouse, Necromys lasiurus. Explants from mid-gestation were cultured in DMEM-High glucose medium with 10% defined fetal bovine serum. The cells were characterized by standard methods including immunophenotyping by fluorescence and flow cytometry, growth and differentiation potential and tumorigenicity assays. The first adherent cells were observed after 7 days of cell culture and included small, elongated fibroblast-like cells (92.13%) and large, round epithelial-like cells with centrally located nuclei (6.5%). Only the fibroblast-like cells survived the first passages. They were positive to markers for mesenchymal stem cells (Stro-1, CD90, CD105, CD73) and pluripotency (Oct3/4, Nanog) as well as precursors of hematopoietic stem cells (CD117). In differentiation assays, they were classified as a multipotent lineage, because they differentiated into osteogenic, adipogenic, and chondrogenic lineages and, finally, they did not develop tumors. In conclusion, mesenchymal progenitor cells with multipotent differentiation potential and sufficient growth and proliferation abilities were able to be obtained from Necromys yolk sacs, therefore, we inferred that these cells may be promising for a wide range of applications in regenerative medicine.

  12. Multiscale Multiphysics Developments for Accident Tolerant Fuel Concepts

    SciTech Connect

    Gamble, K. A.; Hales, J. D.; Yu, J.; Zhang, Y.; Bai, X.; Andersson, D.; Patra, A.; Wen, W.; Tome, C.; Baskes, M.; Martinez, E.; Stanek, C. R.; Miao, Y.; Ye, B.; Hofman, G. L.; Yacout, A. M.; Liu, W.

    2015-09-01

    U3Si2 and iron-chromium-aluminum (Fe-Cr-Al) alloys are two of many proposed accident-tolerant fuel concepts for the fuel and cladding, respectively. The behavior of these materials under normal operating and accident reactor conditions is not well known. As part of the Department of Energy’s Accident Tolerant Fuel High Impact Problem program significant work has been conducted to investigate the U3Si2 and FeCrAl behavior under reactor conditions. This report presents the multiscale and multiphysics effort completed in fiscal year 2015. The report is split into four major categories including Density Functional Theory Developments, Molecular Dynamics Developments, Mesoscale Developments, and Engineering Scale Developments. The work shown here is a compilation of a collaborative effort between Idaho National Laboratory, Los Alamos National Laboratory, Argonne National Laboratory and Anatech Corp.

  13. [Sigmoidoperianal fistula associated with diverticulitis and Cul de Sac situation--diagnostics and therapy].

    PubMed

    Weyand, G; Rinast, E; Englert, A; Houf, M

    2002-07-01

    We report on the case of a 64-year-old female patient who presented herself in our outpatient clinic because of a perianal fistula with recurrent abscesses. We describe the step diagnostics and the surgical treatment of the causal sigmoido-perianal fistula with diverticulitis and Cul de sac situation. Clinical examination, fistulography, colonoscopy and MRT were part of the precise representation and preparation for the high anterior rectosigmoidal resection with simultaneous rectopexy according to Sudeck which were performed without complications. The sigmoidoperianal fistula must be taken into account as a differential diagnosis of a recalcitrant high perianal fistula. PMID:12122593

  14. Water quality in the Little Sac River basin near Springfield, Missouri, 1999-2001

    USGS Publications Warehouse

    Smith, Brenda J.

    2002-01-01

    The Little Sac River, north of Springfield, Missouri, flows through mainly agricultural and forest land. However, the quality of the river water is a concern because the river flows into Stockton Lake, which is a supplemental drinking water source for Springfield. Large bacterial densities and nutrient concentrations are primary concerns to the water quality of the river.A 29-river mile reach of the Little Sac River is on the 1998 list of waters of Missouri designated under section 303(d) of the Federal Clean Water Act because of fecal coliform densities larger than the Missouri Department of Natural Resources standard (hereinafter referred to as Missouri standard) of 200 colonies per 100 milliliters for whole-body contact recreation. During an investigation of the water quality in the Little Sac River by the U.S. Geological Survey, in cooperation with the Watershed Committee of the Ozarks, fecal coliform bacteria densities exceeded the Missouri standard (the standard applies from April 1 through October 31) in one sample from a site near Walnut Grove. At other sites on the Little Sac River, the Missouri standard was exceeded in two samples and equalled in one sample upstream from the Northwest Wastewater Treatment Plant (NW WTP) and in one sample immediately downstream from the NW WTP.Effluent from the NW WTP flows into the Little Sac River. Annually from April 1 through October 31, the effluent is disinfected to meet the Missouri standard for whole-body contact recreation. Fecal coliform bacteria densities in samples collected during this period generally were less than 100 colonies per 100 milliliters. For the rest of the year when the effluent was not disinfected, the bacteria densities in samples ranged from 50 (sample collected on November 1, 2000) to 10,100 colonies per 100 milliliters (both counts were non-ideal). When the effluent was disinfected and the fecal coliform bacteria density was small, samples from sites upstream and downstream from the NW WTP

  15. Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.

    PubMed

    Wallingford, Mary C; Giachelli, Cecilia M

    2014-08-01

    PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the YS VE. The remodeling defect is not due to an upstream cardiomyocyte requirement for PiT-1, as SM22αCre-specific KO of PiT-1 in the developing heart and the YS mesodermal layer (ME) does not recapitulate the PiT-1 global KO phenotype. Furthermore, we find that high levels of PiT-1 protein localize to the YS VE apical membrane. Together these data support that PiT-1 is likely required in YS VE. During normal development maternal immunoglobulin (IgG) is endocytosed into YS VE and accumulates in the apical side of the VE in a specialized lysosome termed the apical vacuole (AV). We have identified a reduction in PiT-1 KO VE cell height and a striking loss of IgG accumulation in the PiT-1 KO VE. The endocytosis genes Tfeb, Lamtor2 and Snx2 are increased at the RNA level. Lysotracker Red staining reveals a loss of distinct AVs, and yolk sacs incubated ex vivo with phRODO Green Dextran for Endocytosis demonstrate a functional loss of endocytosis. As yolk sac endocytosis is controlled in part by microautophagy, but expression of LC3 had not been examined, we investigated LC3 expression during yolk sac development and found stage-specific LC3 RNA expression that is predominantly from the YS VE layer at E9.5. Normalized LC3-II protein levels are decreased in the PiT-1 KO YS, supporting a requirement for PiT-1 in autophagy in the YS. Therefore, we propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the YS VE.

  16. Early sac shrinkage predicts a low risk of late complications after endovascular aortic aneurysm repair

    PubMed Central

    Bastos Gonçalves, F; Baderkhan, H; Verhagen, H J M; Wanhainen, A; Björck, M; Stolker, R J; Hoeks, S E; Mani, K

    2014-01-01

    Background Aneurysm shrinkage has been proposed as a marker of successful endovascular aneurysm repair (EVAR). Patients with early postoperative shrinkage may experience fewer subsequent complications, and consequently require less intensive surveillance. Methods Patients undergoing EVAR from 2000 to 2011 at three vascular centres (in 2 countries), who had two imaging examinations (postoperative and after 6–18 months), were included. Maximum diameter, complications and secondary interventions during follow-up were registered. Patients were categorized according to early sac dynamics. The primary endpoint was freedom from late complications. Secondary endpoints were freedom from secondary intervention, postimplant rupture and direct (type I/III) endoleaks. Results Some 597 EVARs (71·1 per cent of all EVARs) were included. No shrinkage was observed in 284 patients (47·6 per cent), moderate shrinkage (5–9 mm) in 142 (23·8 per cent) and major shrinkage (at least 10 mm) in 171 patients (28·6 per cent). Four years after the index imaging, the rate of freedom from complications was 84·3 (95 per cent confidence interval 78·7 to 89·8), 88·1 (80·6 to 95·5) and 94·4 (90·1 to 98·7) per cent respectively. No shrinkage was an independent risk factor for late complications compared with major shrinkage (hazard ratio (HR) 3·11; P < 0·001). Moderate compared with major shrinkage (HR 2·10; P = 0·022), early postoperative complications (HR 3·34; P < 0·001) and increasing abdominal aortic aneurysm baseline diameter (HR 1·02; P = 0·001) were also risk factors for late complications. Freedom from secondary interventions and direct endoleaks was greater for patients with major sac shrinkage. Conclusion Early change in aneurysm sac diameter is a strong predictor of late complications after EVAR. Patients with major sac shrinkage have a very low risk of complications for up to 5 years. This parameter may be used to tailor postoperative surveillance. PMID:24752772

  17. Use of inverted intestinal sacs to assess the effect of gastrointestinal insult on carcinogen absorption.

    PubMed

    Capel, I D; Cosier, R S; Pinnock, M H; Williams, D C

    1981-01-01

    Rats were subjected to various forms of treatment in the manner likely to induce gastrointestinal insult. These and control animals were sacrificed and, using inverted sacs, the rate of absorption of either dimethylnitrosamine and benzo(a)pyrene determined. The gastrointestinal injury resulting from the differing treatments did not significantly affect the absorption of benzo(a)pyrene, whereas that of dimethylnitrosamine was significantly increased after each incubation time, most notably by alcohol pretreatment. The results demonstrate that intestinal damage increases the absorption of some carcinogens.

  18. Traffic dynamics around weaving section influenced by accident: Cellular automata approach

    NASA Astrophysics Data System (ADS)

    Kong, Lin-Peng; Li, Xin-Gang; Lam, William H. K.

    2015-07-01

    The weaving section, as a typical bottleneck, is one source of vehicle conflicts and an accident-prone area. Traffic accident will block lanes and the road capacity will be reduced. Several models have been established to study the dynamics around traffic bottlenecks. However, little attention has been paid to study the complex traffic dynamics influenced by the combined effects of bottleneck and accident. This paper presents a cellular automaton model to characterize accident-induced traffic behavior around the weaving section. Some effective control measures are proposed and verified for traffic management under accident condition. The total flux as a function of inflow rates, the phase diagrams, the spatial-temporal diagrams, and the density and velocity profiles are presented to analyze the impact of accident. It was shown that the proposed control measures for weaving traffic can improve the capacity of weaving section under both normal and accident conditions; the accidents occurring on median lane in the weaving section are more inclined to cause traffic jam and reduce road capacity; the capacity of weaving section will be greatly reduced when the accident happens downstream the weaving section.

  19. Identification of severe accident uncertainties

    SciTech Connect

    Rivard, J.B.; Behr, V.L.; Easterling, R.G.; Griesmeyer, J.M.; Haskin, F.E.; Hatch, S.W.; Kolaczkowski, A.M.; Lipinski, R.J.; Sherman, M.P.; Taig, A.R.

    1984-09-01

    Understanding of severe accidents in light-water reactors is currently beset with uncertainty. Because the uncertainties that are present limit the capability to analyze the progression and possible consequences of such accidents, they restrict the technical basis for regulatory actions by the US Nuclear Regulatory Commission (NRC). It is thus necessary to attempt to identify the sources and quantify the influence of these uncertainties. As a part of ongoing NRC severe-accident programs at Sandia National Laboratories, a working group was formed to pool relevant knowledge and experience in assessing the uncertainties attending present (1983) knowledge of severe accidents. This initial report of the Severe Accident Uncertainty Analysis (SAUNA) working group has as its main goal the identification of a consolidated list of uncertainties that affect in-plant processes and systems. Many uncertainties have been identified. A set of key uncertainties summarizes many of the identified uncertainties. Quantification of the influence of these uncertainties, a necessary second step, is not attempted in the present report, although attempts are made qualitatively to demonstrate the relevance of the identified uncertainties.

  20. Macroscopic, cytological and bacteriological evaluation of anal sac content in normal dogs and in dogs with selected dermatological diseases.

    PubMed

    Pappalardo, Ersilia; Martino, Piera Anna; Noli, Chiara

    2002-12-01

    Macroscopic and cytological aspects of anal sac content were evaluated in 40 normal dogs and 10 dogs each with pyoderma, Malassezia dermatitis associated with atopic dermatitis and uncomplicated atopic dermatitis. Bacteria isolated from anal sacs were compared with those from abdominal skin and hair in 20 normal dogs and 10 dogs with pyoderma. There was no difference between the groups in anal sac dimension, or in the colour, consistency or presence of granules in their content. Extracellular bacteria were found in higher numbers in diseased animals, whereas intracellular bacteria were observed in 40% of dogs with pyoderma and in only 2.5% of normal dogs. Malassezia spp. were present in 15.7% of dogs, with no difference between groups. Neutrophils were observed in 12.5% of normal dogs, 30% of dogs with Malassezia dermatitis with underlying atopic dermatitis and in 70 and 80% of dogs with pyoderma and uncomplicated atopic dermatitis, respectively. Seven bacterial species were isolated from anal sacs, with no difference between normal dogs and dogs with pyoderma. In five normal animals and in four dogs with pyoderma the same bacterial strains were isolated from anal sacs and from abdominal skin and hair. PMID:12464064

  1. Severe accident simulation at Olkiuoto

    SciTech Connect

    Tirkkonen, H.; Saarenpaeae, T.; Cliff Po, L.C.

    1995-09-01

    A personal computer-based simulator was developed for the Olkiluoto nuclear plant in Finland for training in severe accident management. The generic software PCTRAN was expanded to model the plant-specific features of the ABB Atom designed BWR including its containment over-pressure protection and filtered vent systems. Scenarios including core heat-up, hydrogen generation, core melt and vessel penetration were developed in this work. Radiation leakage paths and dose rate distribution are presented graphically for operator use in diagnosis and mitigation of accidents. Operating on an graphically for operator use in diagnosis and mitigation of accidents. Operating on an 486 DX2-66, PCTRAN-TVO achieves a speed about 15 times faster than real-time. A convenient and user-friendly graphic interface allows full interactive control. In this paper a review of the component models and verification runs are presented.

  2. The child accident repeater: a review.

    PubMed

    Jones, J G

    1980-04-01

    The child accident repeater is defined as one who has at least three accidents that come to medical attention within a year. The accident situation has features in common with those of the child who has a single accident through simple "bad luck", but other factors predispose him to repeated injury. In the child who has a susceptible personality, a tendency for accident repetition may be due to a breakdown in adjustment to a stressful environment. Prevention of repeat accidents should involve the usual measures considered appropriate for all children as well as an attempt to provide treatment of significant maladjustment and modification of a stressful environment.

  3. Metastatic anal sac carcinoma with hypercalcaemia and associated hypertrophic osteopathy in a dog

    PubMed Central

    Giuliano, A.; Salgüero, R.; Dobson, J.

    2015-01-01

    A seven-year-old male neutered Irish setter was treated for a metastatic anal sac adenocarcinoma (ASAC) and hypercalcaemia by complete surgical excision of the primary tumour and partial excision of the sublumbar lymph nodes. Further enlargement of the sublumbar lymph nodes was linked to recurrent hypercalcaemia 3 months after surgical treatment. Medical treatment with Toceranib and Clodronate showed modest results in the treatment of the tumour and the hypercalcaemia. Radiotherapy of the sublumbar lymph nodes and later concurrent carboplatin chemotherapy resulted in partial tumour remission with marked reduction in size of the lymph nodes and normalization of the calcaemia. Unfortunately, concurrently with subsequent relapse of the hypercalaemia, the dog developed hypertrophic osteopathy (HO) and lumbar spinal metastasis and the dog was euthanized. To the authors’ knowledge, this is the second case of metastatic apocrine gland carcinoma of the anal sac associated with HO and the first case that describe the development of HO late in the stage of the disease. PMID:26623365

  4. A novel approach for noninvasive drug delivery and sensing through the amniotic sac.

    PubMed

    Azagury, Aharon; Amar-Lewis, Eliz; Mann, Ella; Goldbart, Riki; Traitel, Tamar; Jelinek, Raz; Hallak, Mordechai; Kost, Joseph

    2014-06-10

    Current invasive prenatal tests (amniocentesis and chorionic villus sampling) are known for their risk to the fetus. In the last decade, the use and awareness of these prenatal tests have increased, resulting in growing demand for a safe, non-invasive, and accurate prenatal test. Chemical penetration enhancers (CPEs) have long been used to increase transport phenomena across skin and other membranes (e.g., tympanic membrane). The amniotic sac membrane is called the chorioamnion (CA) membrane and serves as the physical barrier between the fetus and the mother. In this research, the effect of CPEs on human CA mass transport was evaluated both in vitro and ex vivo. The results show that the tested CPEs exhibit an enhancing effect on CA mass transport. Based on the permeability results, two mechanisms of action were suggested: "extractors" and "fluidizers". Fourier transform infrared (FTIR) and rapid colorimetric screening measurements supported the mechanisms, based on which, more potent compounds were designed and tested for their enhancing effect. The enhancing mass transport effect of CPEs on CA membrane may be used both for sampling of cell-free DNA and for noninvasively administering drugs and other biological agents to the amniotic sac. PMID:24685707

  5. Performance Analysis of SAC Optical PPM-CDMA System-Based Interference Rejection Technique

    NASA Astrophysics Data System (ADS)

    Alsowaidi, N.; Eltaif, Tawfig; Mokhtar, M. R.

    2016-03-01

    In this paper, we aim to theoretically analyse optical code division multiple access (OCDMA) system that based on successive interference cancellation (SIC) using pulse position modulation (PPM), considering the interference between the users, imperfection cancellation occurred during the cancellation process and receiver noises. Spectral amplitude coding (SAC) scheme is used to suppress the overlapping between the users and reduce the receiver noises effect. The theoretical analysis of the multiple access interference (MAI)-limited performance of this approach indicates the influence of the size of M-ary PPM on OCDMA system. The OCDMA system performance improves with increasing M-ary PPM. Therefore, it was found that the SIC/SAC-OCDMA system using PPM technique along with modified prime (MPR) codes used as signature sequence code offers significant improvement over the one without cancellation and it can support up to 103 users at the benchmarking value of bit error rate (BER) = 10-9 with prime number p = 11 while the system without cancellation scheme can support only up to 52 users.

  6. Perforating abomasal ulcer caused by yolk sac tumor in a Holstein calf.

    PubMed

    Sasaki, Hiromi; Goyama, Takashi; Noda, Yoichiro; Matsumoto, Kotaro; Kobayashi, Yoshiyasu; Inokuma, Hisashi

    2012-07-01

    A 2-month-old male Holstein calf showed clinical signs of abdominal bloating, melena, and pain and was suspected of having a perforating abomasal ulcer. Necropsy revealed a large mass located preferentially around the abomasum and a large perforating abomasal ulcer on the pyloric antrum. Milky white masses of various sizes were also found in the abdominal cavity that consisted of agglutinated nodules ranging in size from a pinhead to a golf ball and were distributed on the surfaces of the liver, reticulum, omasum, abomasum, and diaphragm. Microscopic examination revealed that the masses were composed primarily of hyaline matrices, epithelioid tumor cells, and large atypical cells with hyaline droplets and/or vacuoles. Stromal hyaline matrices and hyaline droplets of the large tumor cells stained positive with periodic acid-Schiff stain. Tumor cells showed a positive reaction to anti-human alpha-fetoprotein, which is a marker of yolk sac tumors. These findings strongly suggested that the masses found in the abdominal cavity were yolk sac tumor, a rare germ cell tumor in cattle.

  7. Squamous cell carcinoma of the anal sac in a spotted hyena (Crocuta crocuta).

    PubMed

    Goodnight, Andrea L; Traslavina, Ryan P; Emanuelson, Karen; Affolter, Verena K; Gaffney, Patricia M; Vernau, William; Williams, Colette; Wu, Connie I-kuan; Sturges, Beverly K; Lowenstine, Linda J

    2013-12-01

    A 25-yr-old spayed female spotted hyena (Crocuta crocuta) developed intermittent right pelvic limb lameness that persisted following conservative medical therapy. No obvious musculoskeletal lesions were noted on initial physical exam; however, spinal radiography was suspicious for possible intervertebral degenerative joint disease or discospondylitis. Despite prolonged medical therapy, the lameness progressed to minimal weight bearing and marked muscle atrophy of the right pelvic limb. Electromyography showed spontaneous activity in the muscles of right sciatic nerve distribution. Sensory and motor nerve conduction velocities in the right tibial and peroneal nerves were undetectable and markedly reduced, respectively. A magnetic resonance imaging (MRI) scan revealed a large, space-occupying mass on the right side of the sacrum and pelvis. Antemortem fine-needle aspiration of the mass and postmortem histopathology resulted in diagnosis of a high-grade squamous cell carcinoma of the anal sac. Squamous cell carcinoma of the anal sac is very rare in domestic dogs and previously unreported in spotted hyenas. PMID:24450071

  8. A novel approach for noninvasive drug delivery and sensing through the amniotic sac.

    PubMed

    Azagury, Aharon; Amar-Lewis, Eliz; Mann, Ella; Goldbart, Riki; Traitel, Tamar; Jelinek, Raz; Hallak, Mordechai; Kost, Joseph

    2014-06-10

    Current invasive prenatal tests (amniocentesis and chorionic villus sampling) are known for their risk to the fetus. In the last decade, the use and awareness of these prenatal tests have increased, resulting in growing demand for a safe, non-invasive, and accurate prenatal test. Chemical penetration enhancers (CPEs) have long been used to increase transport phenomena across skin and other membranes (e.g., tympanic membrane). The amniotic sac membrane is called the chorioamnion (CA) membrane and serves as the physical barrier between the fetus and the mother. In this research, the effect of CPEs on human CA mass transport was evaluated both in vitro and ex vivo. The results show that the tested CPEs exhibit an enhancing effect on CA mass transport. Based on the permeability results, two mechanisms of action were suggested: "extractors" and "fluidizers". Fourier transform infrared (FTIR) and rapid colorimetric screening measurements supported the mechanisms, based on which, more potent compounds were designed and tested for their enhancing effect. The enhancing mass transport effect of CPEs on CA membrane may be used both for sampling of cell-free DNA and for noninvasively administering drugs and other biological agents to the amniotic sac.

  9. Embryo sac formation and early embryo development in Agave tequilana (Asparagaceae).

    PubMed

    González-Gutiérrez, Alejandra G; Gutiérrez-Mora, Antonia; Rodríguez-Garay, Benjamín

    2014-01-01

    Agave tequilana is an angiosperm species that belongs to the family Asparagaceae (formerly Agavaceae). Even though there is information regarding to some aspects related to the megagametogenesis of A. tequilana, this is the first report describing the complete process of megasporogenesis, megagametogenesis, the early embryo and endosperm development process in detail. The objective of this work was to study and characterize all the above processes and the distinctive morphological changes of the micropylar and chalazal extremes after fertilization in this species. The agave plant material for the present study was collected from commercial plantations in the state of Jalisco, Mexico. Ovules and immature seeds, previously fixed in FAA and kept in ethanol 70%, were stained based on a tissue clarification technique by using a Mayer's-Hematoxylin solution. The tissue clarification technique was successfully used for the characterization of the megasporogenesis, megagametogenesis, mature embryo sac formation, the early embryo and endosperm development processes by studying intact cells. The embryo sac of A. tequilana was confirmed to be of the monosporic Polygonum-type and an helobial endosperm formation. Also, the time-lapse of the developmental processes studied was recorded. PMID:25332875

  10. Squamous cell carcinoma of the anal sac in a spotted hyena (Crocuta crocuta).

    PubMed

    Goodnight, Andrea L; Traslavina, Ryan P; Emanuelson, Karen; Affolter, Verena K; Gaffney, Patricia M; Vernau, William; Williams, Colette; Wu, Connie I-kuan; Sturges, Beverly K; Lowenstine, Linda J

    2013-12-01

    A 25-yr-old spayed female spotted hyena (Crocuta crocuta) developed intermittent right pelvic limb lameness that persisted following conservative medical therapy. No obvious musculoskeletal lesions were noted on initial physical exam; however, spinal radiography was suspicious for possible intervertebral degenerative joint disease or discospondylitis. Despite prolonged medical therapy, the lameness progressed to minimal weight bearing and marked muscle atrophy of the right pelvic limb. Electromyography showed spontaneous activity in the muscles of right sciatic nerve distribution. Sensory and motor nerve conduction velocities in the right tibial and peroneal nerves were undetectable and markedly reduced, respectively. A magnetic resonance imaging (MRI) scan revealed a large, space-occupying mass on the right side of the sacrum and pelvis. Antemortem fine-needle aspiration of the mass and postmortem histopathology resulted in diagnosis of a high-grade squamous cell carcinoma of the anal sac. Squamous cell carcinoma of the anal sac is very rare in domestic dogs and previously unreported in spotted hyenas.

  11. Giant pandas are not an evolutionary cul-de-sac: evidence from multidisciplinary research.

    PubMed

    Wei, Fuwen; Hu, Yibo; Yan, Li; Nie, Yonggang; Wu, Qi; Zhang, Zejun

    2015-01-01

    The giant panda (Ailuropoda melanoleuca) is one of the world's most endangered mammals and remains threatened by environmental and anthropogenic pressure. It is commonly argued that giant pandas are an evolutionary cul-de-sac because of their specialized bamboo diet, phylogenetic changes in body size, small population, low genetic diversity, and low reproductive rate. This notion is incorrect, arose from a poor understanding or appreciation of giant panda biology, and is in need of correction. In this review, we summarize research across morphology, ecology, and genetics to dispel the idea, once and for all, that giant pandas are evolutionary dead-end. The latest and most advanced research shows that giant pandas are successful animals highly adapted to a specialized bamboo diet via morphological, ecological, and genetic adaptations and coadaptation of gut microbiota. We also debunk misconceptions around population size, population growth rate, and genetic variation. During their evolutionary history spanning 8 My, giant pandas have survived diet specialization, massive bamboo flowering and die off, and rapid climate oscillations. Now, they are suffering from enormous human interference. Fortunately, continued conservation effort is greatly reducing impacts from anthropogenic interference and allowing giant panda populations and habitat to recover. Previous ideas of a giant panda evolutionary cul-de-sac resulted from an unsystematic and unsophisticated understanding of their biology and it is time to shed this baggage and focus on the survival and maintenance of this high-profile species. PMID:25274274

  12. Mechanical Properties of Laser-jetted SAC305 Solder on Coated Optical Surfaces

    NASA Astrophysics Data System (ADS)

    Mäusezahl, Max; Hornaff, Marcel; Burkhardt, Thomas; Beckert, Erik

    Micro-optical packaging methods using laser-based Solderjet Bumping are a versatile alternative to established adhesive bonding, featuring the advantages of metallic solder in optical systems. Yet, aging properties have often been studied only for certain use cases. To examine application independent, long-term material properties of SAC305, square substrates of two widely used soda-lime glasses and the ceramic Al2O3 have been coated with a thin metallic layer system to be receptive for metallic solder. Using Solderjet Bumping, SAC305 balls of 400 μm diameter have been processed with different parameters to form an array of solder bumps on each substrate. While aging for two months at elevated temperature and for over a year at room temperature, shear strengths and failure modes of the individual bumps have been measured and compared. The results show that the mechanical stability of such bumps will stabilize on a level known from research by the electronics industry while observing a considerable dependency on the used substrate material.

  13. [Spatial organization of the lesser peritoneal sac during the early stages of human ontogeny].

    PubMed

    Krutsiak, V N; Voĭtiv, Iu Ia

    1984-12-01

    In 63 series of histological sections of human embryos and prefetuses (4-13 weeks) and in 30 corpses of fetuses and stillborns it has been stated that during the 4th week certain changes occur resulting in formation of the lesser peritoneal sac. It further develops into 3 sections: vestibulum bursae omentalis, bursa omentalis proper and cavity of the omentum majus. Spatial-temporal organization of the lesser peritoneal sac is neither connected with development of separate organs or structures, nor with independent growth, but with the process of development of the whole organocomplex of the upper part of the abdominal cavity, formation of topography and organs' fixation, growth peculiarities of the dorsal mesogastrium. The bursa omentalis proper is forming at the expense of retransformation of the hepatogastric pocket, dependent on growth of the dorsal mesogastrium and on a change in the stomach position. The vestibulum bursae omentalis appears in connection with development and formation of the liver topography, lesser omentum and duodenum. The right pulmoesophagial pocket is interrupted by a developing diaphragm with formation of the superior torsion of the bursa omentalis. Disorders in fixation processes of the organs in the superior part of the abdominal cavity and formation of the bursa omentalis topography can serve as a morphological prerequisite for cysts developing in the retroperitoneal space and hernias of the foramen epiploicum.

  14. Fine-needle aspiration cytology of an endometrioid-like variant of yolk sac tumor.

    PubMed

    Strong, J W; Worsham, G F; Baker, A S; Hawk, J C; Austin, R M

    1992-01-01

    A 36-year-old male with a history of immature teratoma and embryonal carcinoma of the testis was admitted to the hospital for abdominal pain and fever. A CT scan revealed a large right abdominal mass. The patient's serum alpha-fetoprotein (AFP) was 46.8 ng/ml (reference < 25 ng/ml). Fine-needle aspiration (FNA) of the mass revealed malignant glandular cells. Chemotherapy was instituted, followed by resection of the large abdominal mass. The tumor was grossly encapsulated, consisting of large areas of necrotic, hemorrhagic tissue surrounded by smaller, multiloculated cysts. Microscopically, the tumor had a villoglandular pattern and variably stratified tall columnar cells. A prominent feature of the columnar cells was supranuclear and subnuclear vacuolization. Intracytoplasmic PAS-positive, diastase-resistant hyaline globules were occasionally present. AFP by immunoperoxidase was prominent within the tumor. This recurrence of the previously diagnosed testicular teratoma with embryonal carcinoma represents a yolk sac tumor with components strongly resembling endometrioid carcinoma, a variant only recently described in eight cases of ovarian origin (Clement et al.: Am J Surg Pathol 1987; 11(10):767-778). We believe this is the first reported case of an endometrioid-like variant of testicular yolk sac tumor and also the first report of the FNA cytology findings in this variant.

  15. Embryo sac formation and early embryo development in Agave tequilana (Asparagaceae).

    PubMed

    González-Gutiérrez, Alejandra G; Gutiérrez-Mora, Antonia; Rodríguez-Garay, Benjamín

    2014-01-01

    Agave tequilana is an angiosperm species that belongs to the family Asparagaceae (formerly Agavaceae). Even though there is information regarding to some aspects related to the megagametogenesis of A. tequilana, this is the first report describing the complete process of megasporogenesis, megagametogenesis, the early embryo and endosperm development process in detail. The objective of this work was to study and characterize all the above processes and the distinctive morphological changes of the micropylar and chalazal extremes after fertilization in this species. The agave plant material for the present study was collected from commercial plantations in the state of Jalisco, Mexico. Ovules and immature seeds, previously fixed in FAA and kept in ethanol 70%, were stained based on a tissue clarification technique by using a Mayer's-Hematoxylin solution. The tissue clarification technique was successfully used for the characterization of the megasporogenesis, megagametogenesis, mature embryo sac formation, the early embryo and endosperm development processes by studying intact cells. The embryo sac of A. tequilana was confirmed to be of the monosporic Polygonum-type and an helobial endosperm formation. Also, the time-lapse of the developmental processes studied was recorded.

  16. Giant pandas are not an evolutionary cul-de-sac: evidence from multidisciplinary research.

    PubMed

    Wei, Fuwen; Hu, Yibo; Yan, Li; Nie, Yonggang; Wu, Qi; Zhang, Zejun

    2015-01-01

    The giant panda (Ailuropoda melanoleuca) is one of the world's most endangered mammals and remains threatened by environmental and anthropogenic pressure. It is commonly argued that giant pandas are an evolutionary cul-de-sac because of their specialized bamboo diet, phylogenetic changes in body size, small population, low genetic diversity, and low reproductive rate. This notion is incorrect, arose from a poor understanding or appreciation of giant panda biology, and is in need of correction. In this review, we summarize research across morphology, ecology, and genetics to dispel the idea, once and for all, that giant pandas are evolutionary dead-end. The latest and most advanced research shows that giant pandas are successful animals highly adapted to a specialized bamboo diet via morphological, ecological, and genetic adaptations and coadaptation of gut microbiota. We also debunk misconceptions around population size, population growth rate, and genetic variation. During their evolutionary history spanning 8 My, giant pandas have survived diet specialization, massive bamboo flowering and die off, and rapid climate oscillations. Now, they are suffering from enormous human interference. Fortunately, continued conservation effort is greatly reducing impacts from anthropogenic interference and allowing giant panda populations and habitat to recover. Previous ideas of a giant panda evolutionary cul-de-sac resulted from an unsystematic and unsophisticated understanding of their biology and it is time to shed this baggage and focus on the survival and maintenance of this high-profile species.

  17. Yolk sac tumor of the external auditory canal: a case report and literature review.

    PubMed

    Shi, Huijuan; Tang, Qionglan; Zhen, Tiantian; Li, Hui; Zhang, Fenfen; Han, Anjia

    2015-01-01

    We report one case of yolk sac tumor of the ear and review the literature. The patient was a 9-month boy who scratched his right ear repeatedly one month ago. Computed tomography scan showed an irregular elongated mass image measuring 42×16 mm was found in the right external auditory canal. The tumor was located underneath of the epidermis with ulceration. Mild or moderate atypical round or oval tumor cells were arranged in nest and reticular pattern around vesicular or cystic spaces. Tumor cells had abundant eosinophilic or clear cytoplasm and marked nucleoli. Mitotic figures were about 7/10 HPF. Poorly formed Schiller-Duvall body was occasionally present. The stroma was loose and rich in capillaries. Hyaline globules could be found in the stroma. Immunohistochemistry staining showed that tumor cells were positive for cytokeratin, SALL4, glypican-3, focal positive for EMA, vimentin, CD10, and CD34, but negative for a-fetoprotein, HCG, PLAP. The serum α-fetoprotein was 664.60 ng/mL (normal, ≤ 25 ng/mL). Yolk sac tumor of the ear is extremely rare, especially α-fetoprotein negative expression in our case. The differential diagnosis includes embryonal rhabdomyosarcoma, paraganglioma, myoepithelioma, carcinoma of skin appendages, and metastatic renal cell carcinoma. PMID:26823835

  18. Investigation of the Challenger Accident

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The work of the Presidential Commission on the Space Shuttle Challenger Accident (hereafter referred to as the Rogers Commission) and the work of the National Aeronautics and Space Administration in investigating the causes of the accident were reviewed. In addition to reviewing the five volumes of the Rogers Commission, the entire direct on-line Rogers Commission data base, which included full-text and document retrieval capability was also reviewed. The findings and recommendations contained also include materials submitted for the record, staff investigations, interviews, and trips.

  19. Brookhaven lecture series No. 227: The Chernobyl accident

    SciTech Connect

    Kouts, H.

    1986-09-24

    This lecture discusses the events leading to, during, and following the Chernobyl Reactor number 4 accident. A description of the light water cooled, graphite moderated reactor, the reactor site conditions leading to meltdown is presented. The emission of radioactive effluents and the biological radiation effects is also discussed. (FI)

  20. New Technologies for Reducing Aviation Weather-Related Accidents

    NASA Technical Reports Server (NTRS)

    Stough, H. Paul, III; Watson, James F., III; Jarrell, Michael A.

    2006-01-01

    The National Aeronautics and Space Administration (NASA) has developed technologies to reduce aviation weather-related accidents. New technologies are presented for data-link and display of weather information to aircraft in flight, for detection of turbulence ahead of aircraft in flight, and for automated insitu reporting of atmospheric conditions from aircraft.

  1. Minimizing Accidents and Risks in High Adventure Outdoor Pursuits.

    ERIC Educational Resources Information Center

    Meier, Joel

    The fundamental dilemma in adventure programming is eliminating unreasonable risks to participants without also reducing levels of excitement, challenge, and stress. Most accidents are caused by a combination of unsafe conditions, unsafe acts, and error judgments. The best and only way to minimize critical human error in adventure programs is…

  2. 49 CFR 195.52 - Immediate notice of certain accidents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52... discovery of a release of the hazardous liquid or carbon dioxide transported resulting in an event described...) Resulted in either a fire or explosion not intentionally set by the operator; (3) Caused estimated...

  3. 49 CFR 195.52 - Telephonic notice of certain accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.52... release of the hazardous liquid or carbon dioxide transported resulting in an event described in § 195.50... fire or explosion not intentionally set by the operator; (3) Caused estimated property...

  4. [Diving accidents. Emergency treatment of serious diving accidents].

    PubMed

    Schröder, S; Lier, H; Wiese, S

    2004-11-01

    Decompression injuries are potentially life-threatening incidents mainly due to a rapid decline in ambient pressure. Decompression illness (DCI) results from the presence of gas bubbles in the blood and tissue. DCI may be classified as decompression sickness (DCS) generated from the liberation of gas bubbles following an oversaturation of tissues with inert gas and arterial gas embolism (AGE) mainly due to pulmonary barotrauma. People working under hyperbaric pressure, e.g. in a caisson for general construction under water, and scuba divers are exposed to certain risks. Diving accidents can be fatal and are often characterized by organ dysfunction, especially neurological deficits. They have become comparatively rare among professional divers and workers. However, since recreational scuba diving is gaining more and more popularity there is an increasing likelihood of severe diving accidents. Thus, emergency staff working close to areas with a high scuba diving activity, e.g. lakes or rivers, may be called more frequently to a scuba diving accident. The correct and professional emergency treatment on site, especially the immediate and continuous administration of normobaric oxygen, is decisive for the outcome of the accident victim. The definitive treatment includes rapid recompression with hyperbaric oxygen. The value of adjunctive medication, however, remains controversial.

  5. Les rivières et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac

    USGS Publications Warehouse

    Taylor, George C.; Lemoine, Rémy C.

    1949-01-01

    Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

  6. Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

    PubMed Central

    Huang, Hai; Kornberg, Thomas B

    2015-01-01

    The flight muscles, dorsal air sacs, wing blades, and thoracic cuticle of the Drosophila adult function in concert, and their progenitor cells develop together in the wing imaginal disc. The wing disc orchestrates dorsal air sac development by producing decapentaplegic and fibroblast growth factor that travel via specific cytonemes in order to signal to the air sac primordium (ASP). Here, we report that cytonemes also link flight muscle progenitors (myoblasts) to disc cells and to the ASP, enabling myoblasts to relay signaling between the disc and the ASP. Frizzled (Fz)-containing myoblast cytonemes take up Wingless (Wg) from the disc, and Delta (Dl)-containing myoblast cytonemes contribute to Notch activation in the ASP. Wg signaling negatively regulates Dl expression in the myoblasts. These results reveal an essential role for cytonemes in Wg and Notch signaling and for a signal relay system in the myoblasts. DOI: http://dx.doi.org/10.7554/eLife.06114.001 PMID:25951303

  7. Characteristics of indomethacin-saccharin (IMC-SAC) co-crystals prepared by an anti-solvent crystallization process.

    PubMed

    Chun, Nan-Hee; Wang, In-Chun; Lee, Min-Jeong; Jung, Yun-Taek; Lee, Sangkil; Kim, Woo-Sik; Choi, Guang J

    2013-11-01

    The creation of co-crystals of various insoluble drug substances has been extensively investigated as a promising approach to improve their pharmaceutical performance. In this study, co-crystal powders of indomethacin and saccharin (IMC-SAC) were prepared by an anti-solvent (water) addition and compared with co-crystals by evaporation method. No successful synthesis of a pharmaceutical co-crystal powder via an anti-solvent approach has been reported. Among solvents examined, methanol was practically the only one that resulted in the formation of highly pure IMC-SAC co-crystal powders by anti-solvent approach. The mechanism of a preferential formation of IMC-SAC co-crystal to IMC was explained with two aspects: phase solubility diagram and solution complexation concept. Accordingly, the anti-solvent approach can be considered as a competitive route for producing pharmaceutical co-crystal powders with acceptable properties.

  8. Histological Analyses Demonstrate the Temporary Contribution of Yolk Sac, Liver, and Bone Marrow to Hematopoiesis during Chicken Development

    PubMed Central

    Guedes, Priscila Tavares; de Oliveira, Barbara Cristina Euzébio Pereira Dias; Manso, Pedro Paulo de Abreu; Caputo, Luzia Fátima Gonçalves; Pelajo-Machado, Marcelo

    2014-01-01

    The use of avian animal models has contributed to the understanding of many aspects of the ontogeny of the hematopoietic system in vertebrates. However, specific events that occur in the model itself are still unclear. There is a lack of consensus, among previous studies, about which is the intermediate site responsible for expansion and differentiation of hematopoietic cells, and the liver's contribution to the development of this system. Here we aimed to evaluate the presence of hematopoiesis in the yolk sac and liver in chickens, from the stages of intra-aortic clusters in the aorta-genital ridges-mesonephros (AGM) region until hatching, and how it relates to the establishment of the bone marrow. Gallus gallus domesticus L. embryos and their respective yolk sacs at embryonic day 3 (E3) and up to E21 were collected and processed according to standard histological techniques for paraffin embedding. The slides were stained with hematoxylin-eosin, Lennert's Giemsa, and Sirius Red at pH 10.2, and investigated by light microscopy. This study demonstrated that the yolk sac was a unique hematopoietic site between E4 and E12. Hematopoiesis occurred in the yolk sac and bone marrow between E13 and E20. The liver showed granulocytic differentiation in the connective tissue of portal spaces at E15 and onwards. The yolk sac showed expansion of erythrocytic and granulocytic lineages from E6 to E19, and E7 to E20, respectively. The results suggest that the yolk sac is the major intermediate erythropoietic and granulopoietic site where expansion and differentiation occur during chicken development. The hepatic hematopoiesis is restricted to the portal spaces and represented by the granulocytic lineage. PMID:24621665

  9. Altered callose deposition during embryo sac formation of multi-pistil mutant (mp1) in Medicago sativa.

    PubMed

    Zhou, H C; Jin, L; Li, J; Wang, X J

    2016-01-01

    Whether callose deposition is the cause or result of ovule sterility in Medicago sativa remains controversial, because it is unclear when and where changes in callose deposition and dissolution occur during fertile and sterile embryo sac formation. Here, alfalfa spontaneous multi-pistil mutant (mp1) and wild-type plants were used to compare the dynamics of callose deposition during embryo sac formation using microscopy. The results showed that both mutant and wild-type plants experienced megasporogenesis and megagametogenesis, and there was no significant difference during megasporogenesis. In contrast to the wild-type plants, in which the mature embryo sac was observed after three continuous cycles of mitosis, functional megaspores of mutant plants developed abnormally after the second round of mitosis, leading to degeneration of synergid, central, and antipodal cells. Callose deposition in both mutant and wild-type plants was first observed in the walls of megasporocytes, and then in the megaspore tetrad walls. After meiosis, the callose wall began to degrade as the functional megaspore underwent mitosis, and almost no callose was observed in the mature embryo sac in wild-type plants. However, callose deposition was observed in mp1 plants around the synergid, and increased with the development of the embryo sac, and was mainly deposited at the micropylar end. Our results indicate that synergid, central, and antipodal cells, which are surrounded by callose, may degrade owing to lack of nutrition. Callose accumulation around the synergid and at the micropylar end may hinder signals required for the pollen tube to enter the embryo sac, leading to abortion. PMID:27323128

  10. Enlarging cells initiating apomixis in Hieracium praealtum transition to an embryo sac program prior to entering mitosis.

    PubMed

    Okada, Takashi; Hu, Yingkao; Tucker, Matthew R; Taylor, Jennifer M; Johnson, Susan D; Spriggs, Andrew; Tsuchiya, Tohru; Oelkers, Karsten; Rodrigues, Julio C M; Koltunow, Anna M G

    2013-09-01

    Hieracium praealtum forms seeds asexually by apomixis. During ovule development, sexual reproduction initiates with megaspore mother cell entry into meiosis and formation of a tetrad of haploid megaspores. The sexual pathway ceases when a diploid aposporous initial (AI) cell differentiates, enlarges, and undergoes mitosis, forming an aposporous embryo sac that displaces sexual structures. Embryo and endosperm development in aposporous embryo sacs is fertilization independent. Transcriptional data relating to apomixis initiation in Hieracium spp. ovules is scarce and the functional identity of the AI cell relative to other ovule cell types is unclear. Enlarging AI cells with undivided nuclei, early aposporous embryo sacs containing two to four nuclei, and random groups of sporophytic ovule cells not undergoing these events were collected by laser capture microdissection. Isolated amplified messenger RNA samples were sequenced using the 454 pyrosequencing platform and comparatively analyzed to establish indicative roles of the captured cell types. Transcriptome and protein motif analyses showed that approximately one-half of the assembled contigs identified homologous sequences in Arabidopsis (Arabidopsis thaliana), of which the vast majority were expressed during early Arabidopsis ovule development. The sporophytic ovule cells were enriched in signaling functions. Gene expression indicative of meiosis was notably absent in enlarging AI cells, consistent with subsequent aposporous embryo sac formation without meiosis. The AI cell transcriptome was most similar to the early aposporous embryo sac transcriptome when comparing known functional annotations and both shared expressed genes involved in gametophyte development, suggesting that the enlarging AI cell is already transitioning to an embryo sac program prior to mitotic division.

  11. 49 CFR 230.22 - Accident reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirements § 230.22 Accident reports. In the case of an accident due to failure, from any cause, of a steam locomotive boiler or any part or appurtenance thereof, resulting in serious injury or death to one or...

  12. Best practices to reduce the accident rate hotel

    NASA Astrophysics Data System (ADS)

    García Revilla, M. R.; Kahale Carrillo, D. T.

    2014-10-01

    Examining the available databases and existing tourism organizations can conclude that appear studies on accidents and their relationship with other variables. But in our case we want to assess this relationship in the performance of the hotel in relation to lower the accident rate. The Industrial Safety studies analyzing this accident causes (why they happen), their sources (committed activities), their agents (participants work means), its type (how the events occur or develop), all in order to develop prevention. In our case, as accidents happen because people commit wrongful acts or because the equipment, tools, machinery or workplaces are not in proper conditions, the preventive point of view we analyze through the incidence of workplace accidents hotel subsector. The crash occurs because there is a risk, so that adequate control of it would avoid despite individual factors. Absenteeism or absence from work was taken into account first by Dubois in 1977, as he realized the time lost in the nineteenth century due to the long working hours, which included the holidays. Motivation and job satisfaction were the elements that have been most important in the phenomenon of social psychology.

  13. Development of emergency response support system for accident management

    SciTech Connect

    Taminami, Tatsuya; Kubota, Ryuji; Kubota, Tadashi; Yamane, Noriyuki

    1997-12-01

    Specific measures for the accident management (AM) are proposed to prevent the severe accident and to mitigate their effects in order to upgrade the safety of nuclear power plants even further. To ensure accident management effective, it is essential to grasp the plant status accurately. In consideration of the above mentioned background, the Emergency Response Support System (ERSS) was developed as a computer assisted prototype system by a joint study of Japanese BWR group. This system judges and predicts the plant status at the emergency condition in a nuclear power plant. This system displays the results of judgment and prediction. The effectiveness of the system was verified through the test and good prospects for applying the system to a plant was obtained. 7 refs., 10 figs.

  14. Tourist visitation impacts of the accident at Three Mile Island

    SciTech Connect

    Himmelberger, J.J.; Ogneva-Himmelberger, Y.A.; Baughman, M.L.

    1993-12-31

    This paper analyzes tourist visitation impacts of the March 27, 1979 accident at Three Mile Island. A review of the literature, supplemented with recollections from Pennsylvanian public officials, are used to specify a conventional tourism impact model which holds that depressed 1979 summer tourism season was more influenced by gasoline shortages and possibly other confounding variables (such as rainy local weather conditions and a polio outbreak) than by the nuclear accident. Regression analysis using monthly visitation data for Hershey Chocolate World, Gettysburg National Park, The Pennsylvania Dutch Convention and Visitor Bureau, and several state parks as dependent variables provide support for this model. Potential tourism implications of an accident at Yucca Mountain are briefly discussed in light of our findings.

  15. Delta launch vehicle accident investigation

    NASA Astrophysics Data System (ADS)

    1986-03-01

    The text of the testimony given by several witnesses during the House hearings on the Delta launch vehicle accident of May 3, 1986 is given. Pre-launch procedures, failure analysis, the possibility of sabotage, and design and testing are among the topics discussed.

  16. Atypical presentation of sacrococcygeal yolk sac tumor in infant: beware of the injuries of the gluteal region.

    PubMed

    Esposito, Francesco; Di Serafino, Marco; Oresta, Patrizia

    2016-09-01

    Malignant sacrococcygeal yolk sac tumor is a rare extra-gonadal germ cell tumor of infancy and childhood. We report the case of a 14-month-old white female infant with a rapidly growing supra-gluteal mass at first misdiagnosed as hemangioma after a clinical assessment. The lesion was then classified as extra-gonadal yolk sac tumor due to alarming ultrasound features, later confirmed at MRI and pathology. This report remarks the need of a rigorous methodology in the ultrasound exploration of the gluteal region. PMID:27635156

  17. Determinants of injuries in passenger vessel accidents.

    PubMed

    Yip, Tsz Leung; Jin, Di; Talley, Wayne K

    2015-09-01

    This paper investigates determinants of crew and passenger injuries in passenger vessel accidents. Crew and passenger injury equations are estimated for ferry, ocean cruise, and river cruise vessel accidents, utilizing detailed data of individual vessel accidents that were investigated by the U.S. Coast Guard during the time period 2001-2008. The estimation results provide empirical evidence (for the first time in the literature) that crew injuries are determinants of passenger injuries in passenger vessel accidents.

  18. Determinants of injuries in passenger vessel accidents.

    PubMed

    Yip, Tsz Leung; Jin, Di; Talley, Wayne K

    2015-09-01

    This paper investigates determinants of crew and passenger injuries in passenger vessel accidents. Crew and passenger injury equations are estimated for ferry, ocean cruise, and river cruise vessel accidents, utilizing detailed data of individual vessel accidents that were investigated by the U.S. Coast Guard during the time period 2001-2008. The estimation results provide empirical evidence (for the first time in the literature) that crew injuries are determinants of passenger injuries in passenger vessel accidents. PMID:26070017

  19. [Risk factors for accidents during sports while serving in German armed forces].

    PubMed

    Gundlach, N; Sammito, S; Böckelmann, I

    2012-03-01

    In the German Armed Forces sports activities should bring the benefits of good health and trained fitness which are the hallmarks of sportsmen. In order to achieve this aim it is important to avoid accidents which negate the benefit of sports. Until today there appear to be no studies in existence which demonstrate the risk factors of sports activities undertaken while in military service. Equivalent studies on civilian sport activities are scarcely comparable. To find out risk factors for accidents with any period of recovery we followed sports accidents while on duty in a German barracks with 4,300 soldiers over a two-year period. Additionally we asked about the time needed for recovery from each accident, parameters of lifestyle, the body mass index and the possibility of a nightshift before each accident. We examined a minimum of 410 accidents. We found associations between the accidents studied and particular risk factors, including doing sports more than two times a week, being active in a fitness or sports club, having the accident together with another sportsman and doing a nightshift before the day of the accident. Bad ground conditions contributed to a large number of accidents. A body mass index of 25 and higher had a significantly prolonged time for recovery. To avoid accidents, sport and ground conditions should be adapted to each other. In addition, overweight people are not only compromised for cardiovascular and neurological diseases but also have a higher risk of needing a prolonged time for recovery, thus it is important that overweight should be avoided and not only just be treated.

  20. Ionic and potential changes of the endolymphatic sac induced by endolymph volume changes.

    PubMed

    Salt, A N; DeMott, J E

    2000-11-01

    The endolymphatic sac (ES) is believed to be the locus for endolymph volume regulation in the inner ear. It has recently been shown that induced endolymph volume changes in the cochlea result in anatomical changes in the ES, suggesting that function of the sac varies according to endolymph volume status. In the present study we have recorded luminal concentrations of K(+) and Na(+) from the ES and the endolymphatic sac potential (ESP) during cochlear endolymph volume changes. ES recordings were made by an extradural approach, thereby preserving normal cerebrospinal fluid resting pressure. Cochlear endolymph volume changes were generated by performing injections or withdrawals through a pipette inserted into endolymph by a round window approach. The pre-treatment concentrations of K(+) and Na(+) in the ES were found to be 8.4 mM (S.D. 3.3, n=8) and 128. 6 mM (S.D. 18.4, n=10) respectively, and the mean ESP was 14.4 mV (S. D. 5.2, n=18). Endolymphatic injections were found to produce a sustained increase in the K(+) content of the ES by an average of 19. 9 mM and to decrease Na(+) by 30.7 mM measured 50 min after the start of injection. The time for K(+) increase to occur was found to correlate with the injected volume, with larger injected volumes producing a more rapid increase. Endolymphatic withdrawals were found to induce a slow decline in endolymphatic K(+) by an average of 3.4 mM measured at 50 min after withdrawal, although no significant change of Na(+) was detected. Volume-induced ESP changes were highly variable. Injections produced a small increase in the mean ESP and withdrawals produced a small decrease but neither change was statistically significant and some animals showed potential changes in the opposite direction. These data show that a change in cochlear endolymph volume status results in a physiologic response of the ES which is sustained for a considerable period. If the ES plays a part in the restoration of normal endolymph volume, this process

  1. NASA Medical Response to Human Spacecraft Accidents

    NASA Technical Reports Server (NTRS)

    Patlach, Robert

    2010-01-01

    Manned space flight is risky business. Accidents have occurred and may occur in the future. NASA's manned space flight programs, with all their successes, have had three fatal accidents, one at the launch pad and two in flight. The Apollo fire and the Challenger and Columbia accidents resulted in a loss of seventeen crewmembers. Russia's manned space flight programs have had three fatal accidents, one ground-based and two in flight. These accidents resulted in the loss of five crewmembers. Additionally, manned spacecraft have encountered numerous close calls with potential for disaster. The NASA Johnson Space Center Flight Safety Office has documented more than 70 spacecraft incidents, many of which could have become serious accidents. At the Johnson Space Center (JSC), medical contingency personnel are assigned to a Mishap Investigation Team. The team deploys to the accident site to gather and preserve evidence for the Accident Investigation Board. The JSC Medical Operations Branch has developed a flight surgeon accident response training class to capture the lessons learned from the Columbia accident. This presentation will address the NASA Mishap Investigation Team's medical objectives, planned response, and potential issues that could arise subsequent to a manned spacecraft accident. Educational Objectives are to understand the medical objectives and issues confronting the Mishap Investigation Team medical personnel subsequent to a human space flight accident.

  2. 48 CFR 836.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Accident prevention. 836... prevention. The contracting officer must insert the clause at 852.236-87, Accident Prevention, in solicitations and contracts for construction that contain the clause at FAR 52.236-13, Accident Prevention....

  3. 48 CFR 636.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Accident prevention. 636... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 636.513 Accident prevention. (a) In... contracting activities shall insert DOSAR 652.236-70, Accident Prevention, in lieu of FAR clause...

  4. 48 CFR 1836.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accident prevention. 1836... 1836.513 Accident prevention. The contracting officer must insert the clause at 1852.223-70, Safety and Health, in lieu of FAR clause 52.236-13, Accident Prevention, and its Alternate I....

  5. 28 CFR 301.106 - Repetitious accidents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Repetitious accidents. 301.106 Section 301.106 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION General § 301.106 Repetitious accidents. If an inmate worker is involved in successive...

  6. 28 CFR 301.106 - Repetitious accidents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Repetitious accidents. 301.106 Section 301.106 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION General § 301.106 Repetitious accidents. If an inmate worker is involved in successive...

  7. Radiation protection issues on preparedness and response for a severe nuclear accident: experiences of the Fukushima accident.

    PubMed

    Homma, T; Takahara, S; Kimura, M; Kinase, S

    2015-06-01

    Radiation protection issues on preparedness and response for a severe nuclear accident are discussed in this paper based on the experiences following the accident at Fukushima Daiichi nuclear power plant. The criteria for use in nuclear emergencies in the Japanese emergency preparedness guide were based on the recommendations of International Commission of Radiological Protection (ICRP) Publications 60 and 63. Although the decision-making process for implementing protective actions relied heavily on computer-based predictive models prior to the accident, urgent protective actions, such as evacuation and sheltering, were implemented effectively based on the plant conditions. As there were no recommendations and criteria for long-term protective actions in the emergency preparedness guide, the recommendations of ICRP Publications 103, 109, and 111 were taken into consideration in determining the temporary relocation of inhabitants of heavily contaminated areas. These recommendations were very useful in deciding the emergency protective actions to take in the early stages of the Fukushima accident. However, some suggestions have been made for improving emergency preparedness and response in the early stages of a severe nuclear accident.

  8. Radiation protection issues on preparedness and response for a severe nuclear accident: experiences of the Fukushima accident.

    PubMed

    Homma, T; Takahara, S; Kimura, M; Kinase, S

    2015-06-01

    Radiation protection issues on preparedness and response for a severe nuclear accident are discussed in this paper based on the experiences following the accident at Fukushima Daiichi nuclear power plant. The criteria for use in nuclear emergencies in the Japanese emergency preparedness guide were based on the recommendations of International Commission of Radiological Protection (ICRP) Publications 60 and 63. Although the decision-making process for implementing protective actions relied heavily on computer-based predictive models prior to the accident, urgent protective actions, such as evacuation and sheltering, were implemented effectively based on the plant conditions. As there were no recommendations and criteria for long-term protective actions in the emergency preparedness guide, the recommendations of ICRP Publications 103, 109, and 111 were taken into consideration in determining the temporary relocation of inhabitants of heavily contaminated areas. These recommendations were very useful in deciding the emergency protective actions to take in the early stages of the Fukushima accident. However, some suggestions have been made for improving emergency preparedness and response in the early stages of a severe nuclear accident. PMID:25915551

  9. The contributions of sleep-related risk factors to diurnal car accidents.

    PubMed

    Lucidi, Fabio; Mallia, Luca; Violani, Cristiano; Giustiniani, Gabriele; Persia, Luca

    2013-03-01

    This study was intended to estimate the presence and number of individual sleep-related risk factors in a sample of diurnal car accidents and to analyze the extent to which these risk factors tended to be more represented in diurnal accidents involving only one vehicle, involving young drivers or occurring on non-urban roads. Two hundred fifty-three drivers involved in diurnal accidents were interviewed immediately after the accidents to assess their sleepiness-related personal conditions and the circumstances prior to the accident (i.e., individual sleep-related risk factors), such as poor sleep, changes in habitual sleeping patterns, prolonged wakefulness, self-reported acute sleepiness and daytime sleepiness, night-shift jobs and insomnia. A total of 12.3% of the drivers were classified as having at least one of the seven risk factors assessed in the study, supporting the general notion that drivers' sleepiness conditions are crucial, even in diurnal driving circumstances in which they are less likely to depend on chrono-biological processes. Furthermore, consistent with the guiding hypotheses, specific sleep-related risk factors were more evident in single (vs. multiple) car accidents, among young drivers and in car accidents occurring on non-urban roads. In summary, sleep-related risk factors seemed to have a negative impact on drivers' safety in circumstances of diurnal driving, especially when the accidents involved young individuals and occurred on non-urban roads. PMID:23246705

  10. The contributions of sleep-related risk factors to diurnal car accidents.

    PubMed

    Lucidi, Fabio; Mallia, Luca; Violani, Cristiano; Giustiniani, Gabriele; Persia, Luca

    2013-03-01

    This study was intended to estimate the presence and number of individual sleep-related risk factors in a sample of diurnal car accidents and to analyze the extent to which these risk factors tended to be more represented in diurnal accidents involving only one vehicle, involving young drivers or occurring on non-urban roads. Two hundred fifty-three drivers involved in diurnal accidents were interviewed immediately after the accidents to assess their sleepiness-related personal conditions and the circumstances prior to the accident (i.e., individual sleep-related risk factors), such as poor sleep, changes in habitual sleeping patterns, prolonged wakefulness, self-reported acute sleepiness and daytime sleepiness, night-shift jobs and insomnia. A total of 12.3% of the drivers were classified as having at least one of the seven risk factors assessed in the study, supporting the general notion that drivers' sleepiness conditions are crucial, even in diurnal driving circumstances in which they are less likely to depend on chrono-biological processes. Furthermore, consistent with the guiding hypotheses, specific sleep-related risk factors were more evident in single (vs. multiple) car accidents, among young drivers and in car accidents occurring on non-urban roads. In summary, sleep-related risk factors seemed to have a negative impact on drivers' safety in circumstances of diurnal driving, especially when the accidents involved young individuals and occurred on non-urban roads.

  11. Fukushima nuclear power plant accident was preventable

    NASA Astrophysics Data System (ADS)

    Kanoglu, Utku; Synolakis, Costas

    2015-04-01

    , insufficient attention was paid to evidence of large tsunamis inundating the region, i.e., AD 869 Jogan and 1677 Empo Boso-oki tsunamis, and the 1896 Sanriku tsunami maximum height in eastern Japan whose maximum runup was 38m. Two, the design safety conditions were different in Onagawa, Fukushima and Tokai NPPs. It is inconceivable to have had different earthquake scenarios for the NPPs at such close distance from each other. Three, studying the sub-standard TEPCO analysis performed only months before the accident shows that it is not the accuracy of numerical computations or the veracity of the computational model that doomed the NPP, but the lack of familiarity with the context of numerical predictions. Inundation projections, even if correct for one particular scenario, need to always be put in context of similar studies and events elsewhere. To put it in colloquial terms, following a recipe from a great cookbook and having great cookware does not always result in great food, if the cook is an amateur. The Fukushima accident was preventable. Had the plant's owner TEPCO and NISA followed international best practices and standards, they would had predicted the possibility of the plant being struck by the size of tsunami that materialized in 2011. If the EDGs had been relocated inland or higher, there would have been no loss of power. A clear chance to have reduced the impact of the tsunami at Fukushima was lost after the 2010 Chilean tsunami. Standards are not only needed for evaluating the vulnerability of NPPs against tsunami attack, but also for evaluating the competence of modelers and evaluators. Acknowledgment: This work is partially supported by the project ASTARTE (Assessment, STrategy And Risk Reduction for Tsunamis in Europe) FP7-ENV2013 6.4-3, Grant 603839 to the Technical University of Crete and the Middle East Technical University.

  12. Advanced sodium fast reactor accident source terms :

    SciTech Connect

    Powers, Dana Auburn; Clement, Bernard; Denning, Richard; Ohno, Shuji; Zeyen, Roland

    2010-09-01

    An expert opinion elicitation has been used to evaluate phenomena that could affect releases of radionuclides during accidents at sodium-cooled fast reactors. The intent was to identify research needed to develop a mechanistic model of radionuclide release for licensing and risk assessment purposes. Experts from the USA, France, the European Union, and Japan identified phenomena that could affect the release of radionuclides under hypothesized accident conditions. They qualitatively evaluated the importance of these phenomena and the need for additional experimental research. The experts identified seven phenomena that are of high importance and have a high need for additional experimental research: High temperature release of radionuclides from fuel during an energetic event Energetic interactions between molten reactor fuel and sodium coolant and associated transfer of radionuclides from the fuel to the coolant Entrainment of fuel and sodium bond material during the depressurization of a fuel rod with breached cladding Rates of radionuclide leaching from fuel by liquid sodium Surface enrichment of sodium pools by dissolved and suspended radionuclides Thermal decomposition of sodium iodide in the containment atmosphere Reactions of iodine species in the containment to form volatile organic iodides. Other issues of high importance were identified that might merit further research as development of the mechanistic model of radionuclide release progressed.

  13. Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.

    PubMed

    Akutsu, Noriyuki; Adachi, Yasushi; Isosaka, Mai; Mita, Hiroaki; Takagi, Hideyasu; Sasaki, Shigeru; Yamamoto, Hiroyuki; Arimura, Yoshiaki; Ishii, Yoshifumi; Masumori, Naoya; Endo, Takao; Shinomura, Yasuhisa

    2015-01-01

    Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma.

  14. Five new species of the Afrotropical dark sac spider genus Messapus Simon, 1898 (Araneae: Corinnidae).

    PubMed

    Haddad, Charles R; Mbo, Zingisile

    2015-12-11

    The Afrotropical dark sac spider genus Messapus Simon, 1898 (Corinnidae: Corinninae) currently only comprises two described species, the type species M. martini Simon, 1898 and M. natalis (Pocock, 1898), which have both recently been redescribed. The leg and setal morphology of Messapus is studied using scanning electron microscopy for the first time, for M. martini and M. tigris sp. n., and additional characters are provided to supplement a recent generic description. Five new species are described in the current paper: M. megae sp. n. (♂ ♀, from Zimbabwe), M. meridionalis sp. n. (♀, from South Africa), M. seiugatus sp. n. (♀, from Guinea), M. tigris sp. n. (♀, from Botswana and Namibia), and M. tropicus sp. n. (♂ ♀, from Democratic Republic of the Congo). All five species are arboreal spiders occurring on bark, lower foliage strata and the canopies of forest and savannah trees. An identification key to the seven species of the genus is provided.

  15. Amniotic Sac Herniation Through a Prior Cornual Scar in The Third Trimester

    PubMed Central

    Saad, Antonio F.; Costantine, Maged M.; Saade, George; Makhlouf, Michel

    2015-01-01

    Introduction Uterine rupture occurs in less than 0.1% of pregnancies. This complication can be detrimental to mother and fetus if not detected and managed in a timely manner. We report an unusual presentation of uterine scar rupture that was diagnosed on ultrasound in a completely stable patient with reassuring fetal status. Case Report A 24-year-old Gravida 5, Para 3 with history of cornual resection for ectopic pregnancy and two previous uterine ruptures presented at 30 weeks' gestation with worsening abdominal pain. Ultrasound identified herniation of the amniotic sac with fetal parts. The patient underwent cesarean delivery and cornual defect repair. Conclusion Close observation and early delivery remain vital to the patient's management. PMID:26495171

  16. Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.

    PubMed

    Akutsu, Noriyuki; Adachi, Yasushi; Isosaka, Mai; Mita, Hiroaki; Takagi, Hideyasu; Sasaki, Shigeru; Yamamoto, Hiroyuki; Arimura, Yoshiaki; Ishii, Yoshifumi; Masumori, Naoya; Endo, Takao; Shinomura, Yasuhisa

    2015-01-01

    Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma. PMID:26073245

  17. Response of the pigeon crop sac to mammotrophic hormones: Comparison between relaxin and prolactin

    SciTech Connect

    Bani, G.; Sacchi, T.B.; Bigazzi, M. )

    1990-10-01

    The effects of relaxin (RLX), a hormone that has previously been demonstrated to have mammotrophic properties, were studied in the pigeon crop sac, a well-known target organ for mammotrophic and lactogenic hormones, and compared with the effects produced by prolactin (PRL). The two hormones were injected directly over the crop at different doses and the response was evaluated after differing times of exposure. RLX causes a dose-related increase in wet and dry weights and ({sup 3}H)thymidine and ({sup 3}H)uridine uptake by the crop mucosa, as well as morphological changes indicating growth and differentiation of the epithelial cells similar to those occurring during physiological activation in incubation and hatching. At the doses assayed, the effects of RLX were nearly identical to those obtained following PRL in the short-term experiments, but differences in functional responses were found in the long-term experiment.

  18. Automatic measurement of early gestational sac diameters from one scan session

    NASA Astrophysics Data System (ADS)

    Zhang, Ling; Chen, Siping; Li, Shengli; Wang, Tianfu

    2011-03-01

    Gestational sac (GS) diameters are commonly measured by routine ultrasound in early pregnancy. However, manually searching for the standardized plane of GS (SPGS) and measuring the diameters are time-consuming. In this paper, we develop a three-stage automatic solution for this procedure. In order to precisely and efficiently locate the position of GS in each frame, a coarse to fine GS detection scheme based on AdaBoost algorithm is explored. Then, an efficient method based on local context information is introduced to reduce the false positives (FP) generated by the above detection process. Finally, a database (DB) guided spectral segmentation is proposed to separate GS region from the background for further diameters measurement. Experiments carried out on 31 videos show that by using the proposed methods, the number of SPGS searching error is only one, and the average measurement error is 0.059 for the length diameters and 0.083 for the depth diameters.

  19. Factors affecting stress assisted corrosion cracking of carbon steel under industrial boiler conditions

    NASA Astrophysics Data System (ADS)

    Yang, Dong

    Failure of carbon steel boiler tubes from waterside has been reported in the utility boilers and industrial boilers for a long time. In industrial boilers, most waterside tube cracks are found near heavy attachment welds on the outer surface and are typically blunt, with multiple bulbous features indicating a discontinuous growth. These types of tube failures are typically referred to as stress assisted corrosion (SAC). For recovery boilers in the pulp and paper industry, these failures are particularly important as any water leak inside the furnace can potentially lead to smelt-water explosion. Metal properties, environmental variables, and stress conditions are the major factors influencing SAC crack initation and propagation in carbon steel boiler tubes. Slow strain rate tests (SSRT) were conducted under boiler water conditions to study the effect of temperature, oxygen level, and stress conditions on crack initation and propagation on SA-210 carbon steel samples machined out of boiler tubes. Heat treatments were also performed to develop various grain size and carbon content on carbon steel samples, and SSRTs were conducted on these samples to examine the effect of microstructure features on SAC cracking. Mechanisms of SAC crack initation and propagation were proposed and validated based on interrupted slow strain tests (ISSRT). Water chemistry guidelines are provided to prevent SAC and fracture mechanics model is developed to predict SAC failure on industrial boiler tubes.

  20. Isolation and characterization of mesenchymal stem cells from the yolk sacs of bovine embryos.

    PubMed

    Mançanares, C A F; Oliveira, V C; Oliveira, L J; Carvalho, A F; Sampaio, R V; Mançanares, A C F; Souza, A F; Perecin, F; Meirelles, F V; Miglino, M A; Ambrósio, C E

    2015-10-01

    The yolk sac (YS) represents a promising source of stem cells for research because of the hematopoietic and mesenchymal cell niches that are present in this structure during the development of the embryo. In this study, we report on the isolation and characterization of YS tissue and mesenchymal stem cells (MSCs) derived from bovine YSs. Our results show that the YS is macroscopically located in the exocoelomic cavity in the ventral portion of the embryo and consists of a transparent membrane formed by a central sac-like portion and two ventrally elongated projections. Immunohistochemistry analyses were positive for OCT4, CD90, CD105, and CD44 markers in the YS of both gestational age groups. The MSCs of bovine YS were isolated using enzymatic digestion and were grown in vitro for at least 11 passages to verify their capacity to proliferate. These cells were also subjected to immunophenotypic characterization that revealed the presence of CD90, CD105, and CD79 and the absence of CD45, CD44, and CD79, which are positive and negative markers of MSCs, respectively. To prove their multipotency, the cells were induced to differentiate into three cell types, chondrocytes, osteoblasts, and adipocytes, which were stained with tissue-specific dyes (chondrogenic: Alcian Blue, osteogenic: Alizarin Red, and adipogenic: Oil Red O) to confirm differentiation. Gene expression analyses showed no differences in the patterns of gene expression between the groups or passages tested, with the exception of the expression of SOX2, which was slightly different in the G1P3 group compared to the other groups. Our results suggest that YS tissue from bovines can be used as a source of MSCs, which makes YS tissue-derived cells an interesting option for cell therapy and regenerative medicine.

  1. The secondary human yolk sac has an immunophenotype indicative of both hepatic and intestinal differentiation.

    PubMed

    Nogales, Francisco F; Dulcey, Isabel

    2012-01-01

    Although the microscopy of the secondary human yolk sac (SHYS) is well known, few studies have addressed its immunohistochemical profile. The SHYS is involved in the synthesis, absorption and transfer of various proteins and behaves as a temporary liver and intestine. The objective of this study was to evaluate the presence of immunohistochemical markers of hepatic and intestinal function in the SHYS. We performed a retrospective histological and immunohistochemical study of 26 SHYS from spontaneous abortions and tubal pregnancies, 15 of which were from the 7th to 8th week. The antibodies used were against alpha-foetoprotein (AFP), glypican 3 (GLP3), hepatocyte-paraffin-1 (HepPar-1), villin, CDX2, SALL4 and podoplanin (D2-40). Early SHYS from the 5th to the 8th week revealed a network of intracellular vesicles communicating with the lumen of endodermal tubules that were highlighted by intense membrane AFP expression. Endodermal cells consistently expressed AFP, GLP3, SALL4, hep-par-1, villin and CDX2, while mesothelial cells only expressed D2-40. The endodermal layer of the SHYS from the 5th to the 8th week revealed a transient canalicular network which was highlighted by strong membranous AFP expression; this may represent the substrate of a SHYS transport system during its period of maximal activity. The synthetic and transfer functions of the yolk sac endoderm were reflected in a hybrid immunophenotype in which proteins characteristic of hepatic function such as AFP, GLP3, SALL4 and hep-par-1 were coexpressed simultaneously with others such as villin and CDX2, indicative of an intestinal role. PMID:23124968

  2. Medical management principles for radiation accidents.

    PubMed

    Meineke, Viktor; van Beuningen, Dirk; Sohns, Torsten; Fliedner, Theodor M

    2003-03-01

    The medical management of radiation accidents requires intensive planning and action. This article looks at the medical management of recent radiation accidents to derive principles for structuring and organizing the treatment of patients who may have radiation-induced health impairments. Although the radiation accidents in Tokai-mura, Japan and Lilo, Georgia were small-scale accidents, they illustrate important and characteristic symptoms and clinical developments. There are lessons to be learned and conclusions to be drawn for the military medical officers concerned with problems of medical management after radiation accidents.

  3. 48 CFR 301.603-74 - Requirement for retention of FAC-C and HHS SAC certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Requirement for retention of FAC-C and HHS SAC certification. 301.603-74 Section 301.603-74 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career...

  4. Location and identification of the collagen found in the 14.5-d rat embryo visceral yolk sac

    PubMed Central

    1982-01-01

    The collagens associated with 14.5-d rat visceral yolk sacs were localized and identified by a variety of procedures. Morphological examination showed that both the visceral epithelium and mesothelium rested upon thin basement membranes, whereas the majority of the extracellular matrix consisted of a stroma containing occasional cells and abundant banded fibrils. Immunohistochemistry at the electron microscope level showed that the basement membranes specifically cross- reacted with antibodies directed against mouse basement membrane components, whereas the stroma specifically cross-reacted with antibodies directed against rat type I collagen. Extractions of acellular visceral yolk sacs and subsequent analyses showed that type I collagen components were prevalent. Furthermore, in vitro biosynthetic studies showed only the presence of type I procollagen components (or their conversion products) and alpha-fetoprotein. These findings, taken together with our previous studies on the 14.5-d rat parietal yolk sac, provide us with protein markers for studying the origin of cells in rat parietovisceral yolk sac carcinomas. PMID:7096438

  5. Combined anti-solvent and cooling method of manufacturing indomethacin-saccharin (IMC-SAC) co-crystal powders

    NASA Astrophysics Data System (ADS)

    Chun, Nan-Hee; Lee, Min-Jeong; Song, Geon-Hyung; Chang, Kwan-Young; Kim, Chang-Sam; Choi, Guang J.

    2014-12-01

    The anti-solvent approach has been demonstrated as one potential industrial method to produce pharmaceutical co-crystal powders with high purity. In this study, we combined the anti-solvent method with cooling to maximize the yield of the solution-based co-crystallization between indomethacin (IMC) and saccharin (SAC). The cooling start time was the key process parameter; other parameters were fixed based on results of preliminary work. Highly pure IMC-SAC co-crystal powders were produced via the combined method, regardless of the cooling start time, and the yield was substantially enhanced. However, some material properties, such as crystallinity and particle size, were affected by the cooling start time; i.e., whether cooling was started before nucleation (pre-nucleation cooling) or after nucleation (post-nucleation cooling). When pre-nucleation cooling was applied, a greater degree of supersaturation led to nucleation of α-IMC and IMC-SAC together. The metastable α-IMC eventually transitioned to stable IMC-SAC co-crystal particles, followed by crystal growth. When post-nucleation cooling was applied, the transient α-IMC was not detected during the entire process.

  6. Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis

    PubMed Central

    2014-01-01

    Abstract Tunicates have high capacities for regeneration but the underlying mechanisms and their relationship to life cycle progression are not well understood. Here we investigate the regeneration of distal structures in the ascidian tunicate Ciona intestinalis. Analysis of regenerative potential along the proximal−distal body axis indicated that distal organs, such as the siphons, their pigmented sensory organs, and the neural complex, could only be replaced from body fragments containing the branchial sac. Distal regeneration involves the formation of a blastema composed of cells that undergo cell proliferation prior to differentiation and cells that differentiate without cell proliferation. Both cell types originate in the branchial sac and appear in the blastema at different times after distal injury. Whereas the branchial sac stem cells are present in young animals, they are depleted in old animals that have lost their regeneration capacity. Thus Ciona adults contain a population of age‐related stem cells located in the branchial sac that are a source of precursors for distal body regeneration. PMID:25893097

  7. Identification of genes potentially related to biomineralization and immunity by transcriptome analysis of pearl sac in pearl oyster Pinctada martensii.

    PubMed

    Zhao, Xiaoxia; Wang, Qingheng; Jiao, Yu; Huang, Ronglian; Deng, Yuewen; Wang, Huan; Du, Xiaodong

    2012-12-01

    Pearl oyster Pinctada martensii is cultured for production of pearl in China. It needs to implant a mantle graft cut from a donor oyster and a seed nucleus into the gonad of the host oyster to produce a pearl. Pearl sac surrounding the nucleus is formed by the proliferation of the implanted mantle graft from the outer mantle epithelial cells in the host oyster. The pearl sac is responsible for production of a cultured pearl. A comprehensive transcriptome analysis on pearl sac will help to understand the mechanism on pearl formation and immune response of host oyster after nucleus implantation. In the present study, 39,400,004 reads were produced from the pearl sac using RNA-sequence technology and then assembled into 102,762 unigenes. More than 22.4% of these unigenes were possibly involved in approximately 219 known signaling pathways. A total of 37,188 unigenes were annotated based on sequences similarities with known proteins. Fifty-one biomineralization-related unigenes and 268 immune-related unigenes were not previously detected in P. martensii. The un-annotated unigenes may be some genes specifically existed in P. martensii. These annotated or un-annotated unigenes in the present studies were valuable for the future investigation on molecular mechanism of pearl formation and immune response of the species.

  8. The endolymphatic sac in patients with Ménière's disease: correlation between the MRI and the surgical findings.

    PubMed

    Kobayashi, M; Fukaya, T; Noda, M

    2000-10-01

    The endolymphatic sac (ES) is thought to have close relations to pathogenesis of endolymphatic hydrops. Here is reported a retrospective study of 41 patients (42 ears) with Meniere's disease who underwent MRI prior to endolymphatic sac surgery. Based on proton-density weighted image (PDI) and T2-weighted image (T2), the ES including an endolymphatic duct (ED) were estimated whether it was detectable or not. Fourteen ESs were detected on both images (Group A), 14 ESs were detected only on PDI (Group B), and the remaining 14 ESs were not detected on either image (Group D). The actual shape of the sac, obtained from surgical findings, was classified into three (normoplastic, atrophic, invisible). Seventeen ears showed normoplastic ESs and 14 showed atrophic ESs. ES was not detected in 11 ears during surgery, and these findings were compared with image classification. From the study data, normoplastic ESs tend to be observed on both images whereas atrophic or invisible sacs were hardly observed on T2. This classification of ES on MRI was thought to correlate with surgical findings and this correlation was statistically significant (Spearman's rank correlation coefficient. r(s) = 0.58, p < 0.01).

  9. Exploratory analysis of Spanish energetic mining accidents.

    PubMed

    Sanmiquel, Lluís; Freijo, Modesto; Rossell, Josep M

    2012-01-01

    Using data on work accidents and annual mining statistics, the paper studies work-related accidents in the Spanish energetic mining sector in 1999-2008. The following 3 parameters are considered: age, experience and size of the mine (in number of workers) where the accident took place. The main objective of this paper is to show the relationship between different accident indicators: risk index (as an expression of the incidence), average duration index for the age and size of the mine variables (as a measure of the seriousness of an accident), and the gravity index for the various sizes of mines (which measures the seriousness of an accident, too). The conclusions of this study could be useful to develop suitable prevention policies that would contribute towards a decrease in work-related accidents in the Spanish energetic mining industry. PMID:22721539

  10. The Concept of Accident Proneness: A Review

    PubMed Central

    Froggatt, Peter; Smiley, James A.

    1964-01-01

    The term accident proneness was coined by psychological research workers in 1926. Since then its concept—that certain individuals are always more likely than others to sustain accidents, even though exposed to equal risk—has been questioned but seldom seriously challenged. This article describes much of the work and theory on which this concept is based, details the difficulties encountered in obtaining valid information and the interpretative errors that can arise from the examination of imperfect data, and explains why accident proneness became so readily accepted as an explanation of the facts. A recent hypothesis of accident causation, namely that a person's accident liability may vary from time to time, is outlined, and the respective abilities of this and of accident proneness to accord with data from the more reliable literature are examined. The authors conclude that the hypothesis of individual variation in liability is more realistic and in better agreement with the data than is accident proneness. PMID:14106130

  11. A Demonstration of the System Assessment Capability (SAC) Rev. 1 Software for the Hanford Remediation Assessment Project

    SciTech Connect

    Eslinger, Paul W.; Kincaid, Charles T.; Nichols, William E.; Wurstner, Signe K.

    2006-11-06

    The System Assessment Capability (SAC) is a suite of interrelated computer codes that provides the capability to conduct large-scale environmental assessments on the Hanford Site. Developed by Pacific Northwest National Laboratory for the Department of Energy, SAC models the fate and transport of radioactive and chemical contaminants, starting with the inventory of those contaminants in waste sites, simulating transport through the environment, and continuing on through impacts to the environment and humans. Separate modules in the SAC address inventory, release from waste forms, water flow and mass transport in the vadose zone, water flow and mass transport in the groundwater, water flow and mass transport in the Columbia River, air transport, and human and ecological impacts. The SAC supports deterministic analyses as well as stochastic analyses using a Monte Carlo approach, enabling SAC users to examine the effect of uncertainties in a number of key parameters. The initial assessment performed with the SAC software identified a number of areas where both the software and the analysis approach could be improved. Since that time the following six major software upgrades have been made: (1) An air pathway model was added to support all-pathway analyses. (2) Models for releases from glass waste forms, buried graphite reactor cores, and buried naval reactor compartments were added. (3) An air-water dual-phase model was added to more accurately track the movement of volatile contaminants in the vadose zone. (4) The ability to run analyses was extended from 1,000 years to 10,000 years or longer after site closure. (5) The vadose zone flow and transport model was upgraded to support two-dimensional or three-dimensional analyses. (6) The ecological model and human risk models were upgraded so the concentrations of contaminants in food products consumed by humans are produced by the ecological model. This report documents the functions in the SAC software and provides a

  12. Source term estimation during incident response to severe nuclear power plant accidents

    SciTech Connect

    McKenna, T.J.; Glitter, J.G.

    1988-10-01

    This document presents a method of source term estimation that reflects the current understanding of source term behavior and that can be used during an event. The various methods of estimating radionuclide release to the environment (source terms) as a result of an accident at a nuclear power reactor are discussed. The major factors affecting potential radionuclide releases off site (source terms) as a result of nuclear power plant accidents are described. The quantification of these factors based on plant instrumentation also is discussed. A range of accident conditions from those within the design basis to the most severe accidents possible are included in the text. A method of gross estimation of accident source terms and their consequences off site is presented. 39 refs., 48 figs., 19 tabs.

  13. Accident/Mishap Investigation System

    NASA Technical Reports Server (NTRS)

    Keller, Richard; Wolfe, Shawn; Gawdiak, Yuri; Carvalho, Robert; Panontin, Tina; Williams, James; Sturken, Ian

    2007-01-01

    InvestigationOrganizer (IO) is a Web-based collaborative information system that integrates the generic functionality of a database, a document repository, a semantic hypermedia browser, and a rule-based inference system with specialized modeling and visualization functionality to support accident/mishap investigation teams. This accessible, online structure is designed to support investigators by allowing them to make explicit, shared, and meaningful links among evidence, causal models, findings, and recommendations.

  14. Evironmental health policy in ukraine after the Chernobyl accident

    SciTech Connect

    Page, G.W.; Bobyleva, O.A.; Naboka, M.V.

    1995-09-01

    The 1986 accident at the Chernobyl nuclear power plant in Ukraine produced severe environmental health problems. This paper reports on the environmental health conditions in Ukraine after the accident and the health policy approaches employed to respond to the environmental conditions and health problems. Crisis conditions and a period of rapid change in Ukraine contributed to the difficulties of developing and implementing policy to address serious environmental health problems. Despite these difficulties, Ukraine is taking effective action. The paper describes the primary environmental health problem areas and the efforts taken to solve them. The effect of intense public fear of radiation on policymaking is described. The paper discusses the ability of public fear to distort health policy towards certain problems, leaving problems of greater importance with fewer resources. 35 refs., 1 fig.

  15. Guidelines for Exposure Assessment in Health Risk Studies Following a Nuclear Reactor Accident

    PubMed Central

    Bouville, André; Linet, Martha S.; Hatch, Maureen; Mabuchi, Kiyohiko

    2013-01-01

    Background: Worldwide concerns regarding health effects after the Chernobyl and Fukushima nuclear power plant accidents indicate a clear need to identify short- and long-term health impacts that might result from accidents in the future. Fundamental to addressing this problem are reliable and accurate radiation dose estimates for the affected populations. The available guidance for activities following nuclear accidents is limited with regard to strategies for dose assessment in health risk studies. Objectives: Here we propose a comprehensive systematic approach to estimating radiation doses for the evaluation of health risks resulting from a nuclear power plant accident, reflected in a set of seven guidelines. Discussion: Four major nuclear reactor accidents have occurred during the history of nuclear power production. The circumstances leading to these accidents were varied, as were the magnitude of the releases of radioactive materials, the pathways by which persons were exposed, the data collected afterward, and the lifestyle factors and dietary consumption that played an important role in the associated radiation exposure of the affected populations. Accidents involving nuclear reactors may occur in the future under a variety of conditions. The guidelines we recommend here are intended to facilitate obtaining reliable dose estimations for a range of different exposure conditions. We recognize that full implementation of the proposed approach may not always be feasible because of other priorities during the nuclear accident emergency and because of limited resources in manpower and equipment. Conclusions: The proposed approach can serve as a basis to optimize the value of radiation dose reconstruction following a nuclear reactor accident. Citation: Bouville A, Linet MS, Hatch M, Mabuchi K, Simon SL. 2014. Guidelines for exposure assessment in health risk studies following a nuclear reactor accident. Environ Health Perspect 122:1–5; http://dx.doi.org/10

  16. [Myocardial infarction as work-related accident: medical and legal problems].

    PubMed

    Szozda, Ryszard; Procek, Marek

    2002-01-01

    An accident is a work-related event caused by an external factor. Therefore, myocardial infarction is also considered, in specific conditions, as a work-related accident. The aim of this study was to present the cause-effect relationship between myocardial infarction and working conditions in the context of a work-related accident characterized by: urgency of event, external factor and relation with working conditions. The attitude of the Supreme Court to the question of certification, highlighting the key issues and facilitating the understanding of the problem and opinions of legal experts on this matter is also discussed. Myocardial infarction as a work-related accident is an issue involving both law and medicine, particularly occupational medicine, that will have to tackle and solve this problem in its several dimensions, including periodical examinations.

  17. Temporal Statistic of Traffic Accidents in Turkey

    NASA Astrophysics Data System (ADS)

    Erdogan, S.; Yalcin, M.; Yilmaz, M.; Korkmaz Takim, A.

    2015-10-01

    Traffic accidents form clusters in terms of geographic space and over time which themselves exhibit distinct spatial and temporal patterns. There is an imperative need to understand how, where and when traffic accidents occur in order to develop appropriate accident reduction strategies. An improved understanding of the location, time and reasons for traffic accidents makes a significant contribution to preventing them. Traffic accident occurrences have been extensively studied from different spatial and temporal points of view using a variety of methodological approaches. In literature, less research has been dedicated to the temporal patterns of traffic accidents. In this paper, the numbers of traffic accidents are normalized according to the traffic volume and the distribution and fluctuation of these accidents is examined in terms of Islamic time intervals. The daily activities and worship of Muslims are arranged according to these time intervals that are spaced fairly throughout the day according to the position of the sun. The Islamic time intervals are never been used before to identify the critical hour for traffic accidents in the world. The results show that the sunrise is the critical time that acts as a threshold in the rate of traffic accidents throughout Turkey in Islamic time intervals.

  18. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

    PubMed

    Takayama, Naoya; Nishikii, Hidekazu; Usui, Joichi; Tsukui, Hiroko; Sawaguchi, Akira; Hiroyama, Takashi; Eto, Koji; Nakauchi, Hiromitsu

    2008-06-01

    Human embryonic stem cells (hESCs) could potentially represent an alternative source for blood transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis. When we cultured hESCs on either C3H10T1/2 or OP-9 cells to facilitate hematopoiesis, we found that exogenous administration of vascular endothelial growth factor promoted the emergence of sac-like structures, which we named embryonic stem cell-derived sacs (ES-sacs). These ES-sacs consisted of multiple cysts demarcated by cellular monolayers that retained some of the properties of endothelial cells. The spherical cells inside ES-sacs expressed primarily CD34, along with VE-cadherin, CD31, CD41a, and CD45, and were able to form hematopoietic colonies in semisolid culture and to differentiate into mature megakaryocytes by day 24 in the presence of thrombopoietin. Apparently, ES-sacs provide a suitable environment for hematopoietic progenitors. Relatively large numbers of mature megakaryocytes could be induced from the hematopoietic progenitors within ES-sacs, which were then able to release platelets that displayed integrin alpha IIb beta 3 activation and spreading in response to ADP or thrombin. This novel protocol thus provides a means of generating platelets from hESCs, which could serve as the basis for efficient production of platelets for clinical transfusion and studies of thrombopoiesis.

  19. Radiological dose assessment for bounding accident scenarios at the Critical Experiment Facility, TA-18, Los Alamos National Laboratory

    SciTech Connect

    1991-09-01

    A computer modeling code, CRIT8, was written to allow prediction of the radiological doses to workers and members of the public resulting from these postulated maximum-effect accidents. The code accounts for the relationships of the initial parent radionuclide inventory at the time of the accident to the growth of radioactive daughter products, and considers the atmospheric conditions at time of release. The code then calculates a dose at chosen receptor locations for the sum of radionuclides produced as a result of the accident. Both criticality and non-criticality accidents are examined.

  20. MSHA releases data on CM crushing accidents

    SciTech Connect

    2007-02-15

    The US Mine Safety and Health Administration (MHSA) recently formed a committee to identify norms and trends in remote control continuous miner crushing accidents. The final report found that these types of accidents commonly happen to experienced miners during routine mining activities, with the majority occurring while moving the miner from one face to another, place changing. Another common aspect of the accidents is that many of the victims are experienced miners who are newly employed at the mine where the accident occurred. Training all employees to stay outside the turning radius of an energized remote control continuous miner, establishing this as a safe operating procedure, and consistently enforcing this practice among miners will reduce these types of accidents. This article was excerpted from the 'Remote Control Continuous Mining Machine Crushing Accident Data Study' published in May 2006. The report may be found from the website: www.msha.gov. 4 figs., 1 tab.

  1. Accident analysis of heavy water cooled thorium breeder reactor

    NASA Astrophysics Data System (ADS)

    Yulianti, Yanti; Su'ud, Zaki; Takaki, Naoyuki

    2015-04-01

    power reactor has a peak value before reactor has new balance condition. The analysis showed that temperatures of fuel and claddings during accident are still below limitations which are in secure condition.

  2. Accident analysis of heavy water cooled thorium breeder reactor

    SciTech Connect

    Yulianti, Yanti; Su’ud, Zaki; Takaki, Naoyuki

    2015-04-16

    power reactor has a peak value before reactor has new balance condition. The analysis showed that temperatures of fuel and claddings during accident are still below limitations which are in secure condition.

  3. Estimation of Explosion Energy Yield at Chernobyl NPP Accident

    NASA Astrophysics Data System (ADS)

    Pakhomov, Sergey A.; Dubasov, Yuri V.

    2010-05-01

    The value of the 133Xe/133mXe isometric activity ratio for the stationary regime of reactor work is about 35, and that for an instant fission (explosion) is about 11, which allowed estimation of the nuclear component of the instant (explosion) energy release during the NPP accident. Atmospheric xenon samples were taken at the trajectory of accident product transfers (in the Cherepovetz area); these samples were measured by a gamma spectrometer, and the 133Xe/133mXe ratio was determined as an average value of 22.4. For estimations a mathematic model was elaborated considering both the value of instant released energy and the schedule of reactor power change before the accident, as well as different fractionation conditions on the isobaric chain. Comparison of estimated results with the experimental data showed the value of the instant specific energy release in the Chernobyl NPP accident to be 2·105-2·106 J/Wt or 6·1014-6·1015 J (100-1,000 kt). This result is matched up to a total reactor power of 3,200 MWt. However this estimate is not comparable with the actual explosion scale estimated as 10t TNT. This suggests a local character of the instant nuclear energy release and makes it possible to estimate the mass of fuel involved in this explosion process to be from 0.01 to 0.1% of total quantity.

  4. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents.

    PubMed

    Wojcik, A; Gregoire, E; Hayata, I; Roy, L; Sommer, S; Stephan, G; Voisin, P

    2004-01-01

    The analysis of chromosomal aberrations in peripheral blood of radiation accident victims is an established method of biological dosimetry. The dose estimate on the basis of an in vitro calibration curve is straightforward when the radiation exposure is homogeneous and the analysis not delayed. In recent years three radiation accidents occurred, where the irradiation or sampling conditions precluded a simple estimation of the dose. During the Georgian accident soldiers carried in their pockets small sources of 137Cs leading to partial and protracted body exposures. During the Tokai-mura accident, three employees involved in the process of 235U enrichment were exposed to very high doses of gamma rays and neutrons. During the Bialystok accident, five patients with breast cancer undergoing radiotherapy were exposed to a single dose of electrons which reached about 100 Gy. In the present paper the approaches chosen to estimate, by cytogenetic methods, the doses absorbed by the people involved in the accidents are described. PMID:15162038

  5. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents.

    PubMed

    Wojcik, A; Gregoire, E; Hayata, I; Roy, L; Sommer, S; Stephan, G; Voisin, P

    2004-01-01

    The analysis of chromosomal aberrations in peripheral blood of radiation accident victims is an established method of biological dosimetry. The dose estimate on the basis of an in vitro calibration curve is straightforward when the radiation exposure is homogeneous and the analysis not delayed. In recent years three radiation accidents occurred, where the irradiation or sampling conditions precluded a simple estimation of the dose. During the Georgian accident soldiers carried in their pockets small sources of 137Cs leading to partial and protracted body exposures. During the Tokai-mura accident, three employees involved in the process of 235U enrichment were exposed to very high doses of gamma rays and neutrons. During the Bialystok accident, five patients with breast cancer undergoing radiotherapy were exposed to a single dose of electrons which reached about 100 Gy. In the present paper the approaches chosen to estimate, by cytogenetic methods, the doses absorbed by the people involved in the accidents are described.

  6. Relative investment in egg load and poison sac in fig wasps: Implications for physiological mechanisms underlying seed and wasp production in figs

    NASA Astrophysics Data System (ADS)

    Martinson, Ellen O.; Jandér, K. Charlotte; Peng, Yan-Qiong; Chen, Huan-Huan; Machado, Carlos A.; Arnold, A. Elizabeth; Herre, Edward Allen

    2014-05-01

    Fig pollinating wasps and most non-pollinator wasps apply secretions from their poison sacs into oviposited flowers that appear necessary to the formation of the galls that their developing offspring consume. Thus, both eggs and poison sac secretions appear to be essential for wasp reproduction, but the relative investment in each is unknown. We measured relative investment in poison sac and egg production in pollinating and non-pollinating wasps associated with seven species of monoecious Panamanian figs representing both active and passive pollination syndromes. We then collected similar data for four fig hosts in China, where some wasp species in the genus Eupristina have lost the ability to pollinate ("cheaters"). All wasps examined possessed large poison sacs, and we found a strong positive correlation between poison sac size and absolute egg production. In the Panamanian species, the relative poison sac to egg investment was highest in the externally ovipositing non-pollinator wasps, followed by active pollinators, then by passive pollinators. Further, pollinator wasps of fig species with demonstrated host sanctions against "cheating" wasps showed higher investment in the poison sac than wasps of species without sanctions. In the Chinese samples, relative investment in the poison sac was indistinguishable between pollinators and "cheaters" associated with the same fig species. We suggest that higher relative investment in poison sac across fig wasp species reflects higher relative difficulty in initiating formation of galls and subsequently obtaining resources from the fig. We discuss the implications for the stability of the fig-wasp mutualism, and for the ability of non-pollinators to exploit this mutualism.

  7. Cardiac damage presenting late after road accidents.

    PubMed Central

    Mackintosh, A F; Fleming, H A

    1981-01-01

    Six examples of cardiac damage secondary to non-penetrating trauma in road accidents are described. In all six cases the lesion was not recognised at the time of the accident but became clinically important two days to 17 years later. As the patients were young or had unusual lesions, the damage could be attributed to the accident. In older patients with common cardiac problems the trauma might not be recognised as the underlying cause. PMID:7330802

  8. Transportation accident scenarios for commercial spent fuel

    SciTech Connect

    Wilmot, E L

    1981-02-01

    A spectrum of high severity, low probability, transportation accident scenarios involving commercial spent fuel is presented together with mechanisms, pathways and quantities of material that might be released from spent fuel to the environment. These scenarios are based on conclusions from a workshop, conducted in May 1980 to discuss transportation accident scenarios, in which a group of experts reviewed and critiqued available literature relating to spent fuel behavior and cask response in accidents.

  9. The effect of gamma-ray transport on afterheat calculations for accident analysis

    SciTech Connect

    Reyes, S.; Latkowski, J.F.; Sanz, J.

    2000-05-01

    Radioactive afterheat is an important source term for the release of radionuclides in fusion systems under accident conditions. Heat transfer calculations are used to determine time-temperature histories in regions of interest, but the true source term needs to be the effective afterheat, which considers the transport of penetrating gamma rays. Without consideration of photon transport, accident temperatures may be overestimated in others. The importance of this effect is demonstrated for a simple, one-dimensional problem. The significance of this effect depends strongly on the accident scenario being analyzed.

  10. RADIS - a regional nuclear accident consequence analysis model for Hong Kong

    SciTech Connect

    Yeung, Mankit Ray; Ching, E.M.K. )

    1993-02-01

    An atmospheric dispersion and consequence model called RADIS has been developed by the University of Hong Kong for nuclear accident consequence analysis. The model uses a two-dimensional plume trajectory derived from wind data for Hong Kong. Dose, health effects, and demographic models are also developed and implemented in RADIS so that accident consequences in 15 major population centers of Greater Hong Kong can be determined individually. In addition, benchmark testing results are give, and comparisons with the analytical solution and CRAC2 results are consistent and satisfactory. Sample calculational results for severe accident consequences are also presented to demonstrate the applicability of RADIS for dry and wet weather conditions.

  11. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect

    Ryan, G.W., Westinghouse Hanford

    1996-07-12

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  12. Industrial Safety and Accidents Prevention

    SciTech Connect

    Sajjad Akbar

    2006-07-01

    Accident Hazards, dangers, losses and risk are what we would to like to eliminate, minimize or avoid in industry. Modern industries have created many opportunities for these against which man's primitive instincts offer no protection. In today's complex industrial environment safety has become major preoccupation, especially after the realization that there is a clear economic incentive to do so. Industrial hazards may cause by human error or by physical or mechanical malfunction, it is very often possible to eliminate the worst consequences of human error by engineering modification. But the modification also needs checking very thoroughly to ensue that it has not introduced some new and unsuspected hazard. (author)

  13. Estimation Of 137Cs Using Atmospheric Dispersion Models After A Nuclear Reactor Accident

    NASA Astrophysics Data System (ADS)

    Simsek, V.; Kindap, T.; Unal, A.; Pozzoli, L.; Karaca, M.

    2012-04-01

    Nuclear energy will continue to have an important role in the production of electricity in the world as the need of energy grows up. But the safety of power plants will always be a question mark for people because of the accidents happened in the past. Chernobyl nuclear reactor accident which happened in 26 April 1986 was the biggest nuclear accident ever. Because of explosion and fire large quantities of radioactive material was released to the atmosphere. The release of the radioactive particles because of accident affected not only its region but the entire Northern hemisphere. But much of the radioactive material was spread over west USSR and Europe. There are many studies about distribution of radioactive particles and the deposition of radionuclides all over Europe. But this was not true for Turkey especially for the deposition of radionuclides released after Chernobyl nuclear reactor accident and the radiation doses received by people. The aim of this study is to determine the radiation doses received by people living in Turkish territory after Chernobyl nuclear reactor accident and use this method in case of an emergency. For this purpose The Weather Research and Forecasting (WRF) Model was used to simulate meteorological conditions after the accident. The results of WRF which were for the 12 days after accident were used as input data for the HYSPLIT model. NOAA-ARL's (National Oceanic and Atmospheric Administration Air Resources Laboratory) dispersion model HYSPLIT was used to simulate the 137Cs distrubition. The deposition values of 137Cs in our domain after Chernobyl Nuclear Reactor Accident were between 1.2E-37 Bq/m2 and 3.5E+08 Bq/m2. The results showed that Turkey was affected because of the accident especially the Black Sea Region. And the doses were calculated by using GENII-LIN which is multipurpose health physics code.

  14. The determinants of fishing vessel accident severity.

    PubMed

    Jin, Di

    2014-05-01

    The study examines the determinants of fishing vessel accident severity in the Northeastern United States using vessel accident data from the U.S. Coast Guard for 2001-2008. Vessel damage and crew injury severity equations were estimated separately utilizing the ordered probit model. The results suggest that fishing vessel accident severity is significantly affected by several types of accidents. Vessel damage severity is positively associated with loss of stability, sinking, daytime wind speed, vessel age, and distance to shore. Vessel damage severity is negatively associated with vessel size and daytime sea level pressure. Crew injury severity is also positively related to the loss of vessel stability and sinking.

  15. Aircraft Loss-of-Control Accident Analysis

    NASA Technical Reports Server (NTRS)

    Belcastro, Christine M.; Foster, John V.

    2010-01-01

    Loss of control remains one of the largest contributors to fatal aircraft accidents worldwide. Aircraft loss-of-control accidents are complex in that they can result from numerous causal and contributing factors acting alone or (more often) in combination. Hence, there is no single intervention strategy to prevent these accidents. To gain a better understanding into aircraft loss-of-control events and possible intervention strategies, this paper presents a detailed analysis of loss-of-control accident data (predominantly from Part 121), including worst case combinations of causal and contributing factors and their sequencing. Future potential risks are also considered.

  16. [SAFETY IN THE ELDERLY: HOME ACCIDENTS].

    PubMed

    Martín-Espinosa, Noelia M; Píriz-Campos, Rosa Ma; Cordeiro, Raú; Muñoz Bermejo, Laura; Casado Verdjo, Inés; Postigo Mota, Salvador

    2016-05-01

    Home accidents are more common in the elderly and they can have serious consequences to the injured person's health. At home, chances to suffer accidents of any type are higher, because it's the place where old people spend most of their daily time. It is important to point out that a high percentage of domestic accidents could be easily avoided by taking some simple cautions. The main aim of this paper is to know how we can prevent most common domestic accidents in the aged population: falls, burnings, poisonings and fire prevention. PMID:27405149

  17. The determinants of fishing vessel accident severity.

    PubMed

    Jin, Di

    2014-05-01

    The study examines the determinants of fishing vessel accident severity in the Northeastern United States using vessel accident data from the U.S. Coast Guard for 2001-2008. Vessel damage and crew injury severity equations were estimated separately utilizing the ordered probit model. The results suggest that fishing vessel accident severity is significantly affected by several types of accidents. Vessel damage severity is positively associated with loss of stability, sinking, daytime wind speed, vessel age, and distance to shore. Vessel damage severity is negatively associated with vessel size and daytime sea level pressure. Crew injury severity is also positively related to the loss of vessel stability and sinking. PMID:24473412

  18. Expression of the Bacillus subtilis sacB gene leads to sucrose sensitivity in the gram-positive bacterium Corynebacterium glutamicum but not in Streptomyces lividans.

    PubMed Central

    Jäger, W; Schäfer, A; Pühler, A; Labes, G; Wohlleben, W

    1992-01-01

    The expression of the structural gene (sacB) encoding Bacillus subtilis levansucrase in two gram-positive soil bacteria, Corynebacterium glutamicum ATCC 13032 and Streptomyces lividans 1326, was investigated. sacB expression in the presence of sucrose is lethal to C. glutamicum but not to S. lividans. While S. lividans secretes levansucrase into the medium, we could show that the enzyme is retained by C. glutamicum cells. Our results imply that the sacB gene can be used as a positive selection system in coryneform bacteria. PMID:1644774

  19. IMAGING DIAGNOSIS--USE OF RADIOGRAPHY AND COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF A MINERALIZED YOLK SAC IN A BROWN KIWI (APTERYX MANTELLI).

    PubMed

    Wightman, Paul; Cohen, Eli B; Hunter, Stuart; Gartrell, Brett

    2015-01-01

    A 12-day-old Brown Kiwi (Apteryx mantelli) was presented with anorexia, torticollis, head-tilt, and coelomic distension. Radiographs showed an ill-defined, fat-opaque, coelomic mass displacing viscera craniodorsally. Curvilinear mineral opacities were superimposed over the ventral aspect of the mass. Computed tomography demonstrated the presence of mineral within the periphery of a fat attenuating mass consistent with a retained yolk sac. A deutectomy (yolk sac excision) was performed. Histopathology of the excised tissue confirmed the diagnosis of a retained yolk sac with multifocal mineralization. PMID:25199884

  20. Experimental Model of Saccular Abdominal Aortic Aneurysm in Swines with Pericardium Sac

    PubMed Central

    Aquino, Maurício de Amorim; de Barros, Svetlana Maria Wanderley; Castro, Aldemar Araújo; Pitta, Guilherme Benjamin Brandão; Pereira, Adamastor Humberto

    2016-01-01

    Objective: To consider modifications in an experimental model of saccular aortic aneurysm, aiming at better reproducibility, to be used in the development of vascular prostheses. Methods: Experimental study in two phases, developed in the Center of Experimental Surgery and Bioterium (CCEB) of the University of Health Sciences of Alagoas (UNCISAL), with 11 hybrid swine, female, mean weight of 20 ± 5 kg, according to modifications in the Perini technique was performed. In the first phase, the aneurysm was confectioned with bovine pericardial patch. In the second phase, fifteen days later, the patency of the aneurysms was confirmed by Doppler ultrasonography. The described variables were aortic and aneurysm sac patency, incidence of rupture, morbidity and mortality. The statistical analysis program used was STATA v.8. Results: All animals survived to the procedures. Surgical mean time was 73 minutes. Aneurysm rupture, proximal or distal aortic thrombosis, visceral or legs ischemia weren't observed. Parietal thrombus formation was observed in all of the aneurysms, two of which (18%; IC 95% = 3.98 - 48.84) were occluded and nine (82%; IC 95% = 51.15 - 96.01) were patent. Conclusion: In this series, the modifications carried out in the technique related to the surgical approach, race, anesthesia, and imaging exams reproduced the experimental model, reducing its costs, without hindering the analysis of the variables. The satisfactory patency ratio allows the method to be used in experimental models for the development of vascular prostheses. PMID:27074279

  1. Impact of new technology weapons on SAC (Strategic Air Command) conventional air operations. Research report

    SciTech Connect

    Bodenheimer, C.E.

    1983-06-01

    Chapter I introduces the issue of conventional-response capability. The point stressed first is that the strategic bomber's primary mission is in support of the single integrated operations plan (SIOP) as a nuclear weapons delivery vehicle. However, as cited by Secretary of Defense Caspar Weinberger, we must have a rapid deployment conventional capability to areas where there are small if any U.S. forces present. The SAC strategic projection force (SPF) is available but with gravity weapons of World War II vintage. New technology can provide answers to the problem by providing highly accurate long-range conventional standoff weapons. Chapter II gives a basic historical perspective on the use of the strategic bomber in past wars. It discusses the development of strategy, weapons, and targets in World War II, Korean War, and Vietnam War. Chapter III presents a very brief look at current US policy, strategy, and guidance. Chapter IV covers the aircraft attrition issue in today's highly lethal defensive environment. Chapter V describes the development of air-to-ground weapons. Chapter VI addresses the potential for the future in the shifting balance of Soviet and US technology. The final chapter makes the point that a decision must be made on weapons-acquisition programs and bomber force structure. New technology-standoff conventional weapons could make AAA and SAM defenses a modern Maginot Line.

  2. Mass-marking of otoliths of lake trout sac fry by temperature manipulation

    USGS Publications Warehouse

    Bergstedt, Roger A.; Eshenroder, Randy L.; Bowen, Charles; Seelye, James G.; Locke, Jeffrey C.

    1990-01-01

    The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about 10 degrees C (from a base of 1-4 degrees C) over 14 h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98, and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of rings.

  3. Mass-marking of otoliths of lake trout sac fry by temperature manipulation

    USGS Publications Warehouse

    Bergstedt, R.A.; Eshenroder, R.L.; Bowen, C. II; Seelye, J.G.; Locke, J.C.; Parker, N.C.; Giorgi, A.E.; Heidenger, R.C.; Jester, D. B.; Prince, E.D.; Winans, G.A.

    1990-01-01

    The otoliths of 676,000 sac fry of lake trout Salvelinus namaycush in 1986, and of 1,100,000 in 1987, were marked by daily manipulation of water temperature. The fish were stocked into Lake Huron in the spring. Otolith marks consisted of groups of daily growth rings accentuated into recognizable patterns by steadily raising and lowering the temperature about IOA?C (from a base of 1-4A?C) over 14h. In 1987, groups of marked and control fish were held for 6 months. The otoliths were removed from samples of the fish, embedded in epoxy, thin-sectioned by grinding in the sagittal plane, etched, and viewed by using a combination of a compound microscope (400-1000x) and a video enhancement system. One or more readable otolith sections were obtained from 39 of a sample of 40 fish. Three independent readers examined 41 otoliths for marks and correctly classified the otoliths, with accuracies of 85, 98,and 100%, as being from marked or unmarked fish. The exact number of rings in a recognizable pattern sometimes differed from the number of temperature cycles to which the fish were exposed. Counts of daily rings within groups of six rings varied less than counts within groups of three rings.

  4. Migrating bullet in the thecal sac at the level of the conus medullaris without neurological deficit.

    PubMed

    Koban, Orkun; Çal, Hasan; Ekşi, Murat Şakir; Özcan-Ekşi, Emel Ece; Öğrenci, Ahmet

    2016-07-01

    Bullets can lodge in the organs, blood vessels or thecal sac. To our knowledge, a migrating bullet at the level of the conus medullaris without neurological deficit has never been reported. We present our patient along with a discussion of bullet migration in the spinal canal and its mechanisms, diagnosis and treatment. A 29-year-old man was admitted to the emergency department due to a gunshot wound in the right upper quadrant of his abdomen. He had no neurological deficit. Spinal CT scan and plain radiography showed the bullet had passed through the L2 vertebral body and had migrated downwards until it had lost its energy and come to rest in the spinal canal at the L3 vertebra level. There was a grade 5 injury to the pancreas head concomitant with mesenteric injury of the transverse colon, harboring a 0.5 cm hole. He had an emergent laparotomy to have a Roux-en-Y reconstruction and repair of the transverse colon. After his general status stabilized, he was taken back to the operating room to extract the bullet from the spinal canal. L3 and partial L2 laminectomy were performed. The dura was opened and the bullet was observed intrathecally. No cerebrospinal fluid fistula was observed. The surgeries and post-operative period were uneventful.

  5. [Pseudomyxoma peritonei spread into the right inguinal hernia sac--a case report].

    PubMed

    Cichon, Paulina; Drucis, Kamil; Kakol, Michal; Jastrzebski, Tomasz; Polec, Tomasz

    2013-10-01

    Pseudomyxoma peritonei (PMP) is a rare, progressive disease of unknown origin. The incidence is estimated at about 1-2/100,000,000 per year. The primary tumor site is usually discovered in the appendix or- in case of women--in ovaries, appearing as tumors of low malignancy. Making an accurate diagnosis causes difficulties--symptoms tend to be misleading, suggesting more frequent pathologies of the abdominal cavity. It is also not rare that the patient is for a long time asymptomatic. We present a case of a 68-year-old patient of the Surgical Oncology Department treated for pseudomyxoma peritonei, diagnosed incidentally at the time of clinical examination for the reasons of chronic hypertension. The symptoms reported by the patient did not suggest any neoplastic process of the peritoneal cavity. Systemic chemotherapy of two paths (a total number of 10 cycles) did not result and at the time of post-treatment control, due to no response to standard chemotherapy, it was decided to administer chemotherapy intraperitoneally in hyperthermia (HIPEC). During the operation, peritoneal cytoreduction prior to the scheduled HIPEC was performed; the right-sided inguinal hernia was repaired. Within the hernia sac the implanted myxoid cells were found, their presence inside was probably the main reason of clinical manifestation of the disease. PMID:24340893

  6. Integrated Phase Array Antenna/Solar Cell System for Flexible Access Communication (IA/SAC)

    NASA Technical Reports Server (NTRS)

    Clark, E. B.; Lee, R. Q.; Pal, A. T.; Wilt, D. M.; McElroy, B. D.; Mueller, C. H.

    2005-01-01

    This paper describes recent efforts to integrate advanced solar cells with printed planar antennas. Several previous attempts have been reported in the literature, but this effort is unique in several ways. It uses Gallium Arsenide (GaAs) multi-junction solar cell technology. The solar cells and antennas will be integrated onto a common GaAs substrate. When fully implemented, IA/SAC will be capable of dynamic beam steering. In addition, this program targets the X-band (8 - 12 GHz) and higher frequencies, as compared to the 2.2 - 2.9 GHz arrays targeted by other organizations. These higher operating frequencies enable a greater bandwidth and thus higher data transfer rates. The first phase of the effort involves the development of 2 x 2 cm GaAs Monolithically Integrated Modules (MIM) with integrated patch antennas on the opposite side of the substrate. Subsequent work will involve the design and development of devices having the GaAs MIMs and the antennas on the same side of the substrate. Results from the phase one efforts will be presented.

  7. [Absorption of aqueous extracts from Salviae Miltiorrhizae Radix et Rhizoma by everted intestinal sac method].

    PubMed

    Zhao, Jie; Xu, Xue-lin; Yi, Hong; Zhang, Hong-min; Liu, Xiao-qian; Zhu, Jing-jing; Wang, Zhi-min

    2015-08-01

    To study the absorptive characteristics of aqueous extracts from Salviae Miltiorrhizae Radix et Rhizoma by in vitro rat everted intestinal sac model. Three representative ingredients in aqueous extracts from Salviae Miltiorrhizae Radix et Rhizome--protocatechuic aldehyde (PAL), posmarinic acid (RA) and salvianolic acid B (SAB), were selected as the study objects. An UPLC method was established to determine and measure their cumulative absorption amount, in order to explain the absorption characteristics of ingredients in different intestinal sections. According to the experimental result, RA and SAB showed the passive absorption in ileum, which conformed to the first-order absorption rate; with low and medium doses, they showed a zero-order absorption rate in jejunum, which was reflected in the coexistence of both positive and passive absorptions; PAL showed a passive absorption manner both in ileum and jejunum. According to the experiment for absorption in different intestinal sections, RA and SAB were mainly absorbed in jejunum, while PAL was absorbed mainly in ileum. All of the three ingredients in aqueous extracts from Salviae Miltiorrhizae Radix et rhizome--PAL, RA and SAB could be absorbed in intestines, but with differences in the absorption rate and mechanism, which indicated that the intestinal absorption of aqueous extracts from Salviae Miltiorrhizae Radix et rhizome was selectivity, instead of a simple semi-permeable membrane penetration process.

  8. Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in sorghum ovules

    PubMed Central

    2011-01-01

    Background Genetically unreduced (2n) embryo sacs (ES) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n ES form precociously during ovule development. Whether meiosis and sexual ES formation also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction) has not been studied. We determined onset timing of meiosis and sexual ES formation for 569 Sorghum bicolor genotypes, many of which produced 2n ES facultatively. Results Genotype differences for onset timing of meiosis and sexual ES formation, relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic ES, which formed from nucellar cells (apospory) in some genotypes. Genotypes that produced these aposporous ES underwent meiosis and sexual ES formation precociously. Aposporous ES formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. Conclusions The present study adds meiosis and sexual ES formation to floral induction, apomictic ES formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction. PMID:21223576

  9. Fetus in fetu: a case with complete umbilical cord and fetal sac.

    PubMed

    Kang, Y K; Suh, Y L; Kim, C W; Chi, J G

    1994-01-01

    The authors present a retroperitoneal fetus in fetus in a 3-month-old girl. A 15-cm cystic mass with a monstrous fetuslike structure surrounded by a complete sac containing serous fluid was removed from the left retroperitoneal space. The draining vessel of the cystic mass was connected to the right renal vein of the host. The included fetus weighed 380 g. It had a well-developed umbilical cord, four extremities, head, buttock, and vertebral bodies with a meningomyelocele. The thoracic cavity of the included fetus had only a saclike foregut structure, but the abdominal cavity revealed a full length of intestine with a Meckel diverticulum, bilateral ovaries, urinary bladder, and cloaca with external opening. The cephalic end was composed of well-developed tooth germs, tongue and buccopharynx, mandible, maxilla, sphenoid bone, and salivary glands. Chromosomal study showed 46,XX with a normal G banding pattern. We report this case as an example of fetus in fetu with a complete umbilical cord and fetal membrane.

  10. Effect of blue LED light intensity on carotenoid accumulation in citrus juice sacs.

    PubMed

    Zhang, Lancui; Ma, Gang; Yamawaki, Kazuki; Ikoma, Yoshinori; Matsumoto, Hikaru; Yoshioka, Terutaka; Ohta, Satoshi; Kato, Masaya

    2015-09-01

    In the present study, the effects of blue LED light intensity on carotenoid accumulation and expression of genes related to carotenoid biosynthesis were investigated in the juice sacs of Satsuma mandarin (Citrus unshiu Marc.) and Valencia orange (Citrus sinensis Osbeck) in vitro. The results showed that 100 μmol m(-2)s(-1) blue LED light (100B) was effective for increasing carotenoid content, especially β-cryptoxanthin, in Satsuma mandarin after cultured in vitro for four weeks. In Valencia orange, in contrast, 50 μmol m(-2)s(-1) blue LED light (50B) treatment was effective for inducing carotenoid accumulation through increasing the contents of two major carotenoids, all-trans-violaxanthin and 9-cis-violaxanthin. In addition, gene expression results showed that the simultaneous increases in the expression of genes (CitPSY, CitPDS, CitZDS, CitLCYb2, and CitHYb) involved in producing β,β-xanthophylls were well consistent with the accumulation of β-cryptoxanthin in Satsuma mandarin under 100B, and violaxanthin in Valencia orange under 50B. The results presented herein contribute to further elucidating the regulatory mechanism of carotenoid accumulation by blue LED light.

  11. Occupational accidents and forensic medicine in Turkey.

    PubMed

    Ince, Haluk; Ince, Nurhan; Ozyildirim, Bedia Ayhan

    2006-01-01

    In Turkey, evaluation of the ratio of loss of working capacity is made according to various laws and regulations. These laws and regulations use different standards in computing the above-mentioned ratio depending on the professional status of the worker, whether he or she is a member of SSK (Social Security Institution) or ES (The Retirement Pension Institution) system. The aim of this study is to point out at the differences and deficiencies in computing the degree of disability and at the need to bring common standards to these computations. This prospective descriptive research is based on the cases of occupational accidents and occupational diseases brought to the 3rd specialized branch of the Institution of Forensic Medicine (which is the highest ruling instance concerning the decision on this field). Of the 164 accident cases included in this research, 95.1% are males, and 4.9% females. According to distribution by age of the cases, the modal group is respectively (30-39) years for men and (12-19) years for women. 43.8% of the injuries were localized at the hand or wrist. No meaningful statistical relationship could be found between the level of qualification of the workers (skilled-unskilled) and the proportion of those suffering from total disability. For the cases included in the categories 3, 4 and 5 is the ES system; the ratio of disability was similar to those computed according to the SSK system. In conclusion, we would like to insist on the need for our country to amend our laws and regulations according to changing and prevailing conditions and sex differentials and to bring homogeneous standards for all workers.

  12. Biorhythmic Cycles and the Incidence of Industrial Accidents

    ERIC Educational Resources Information Center

    Carvey, Davis W.; Nibler, Roger G.

    1977-01-01

    The biorhythm theory of accident explanation that has been increasingly popularized in the business press was empirically examined. Municipal employees involved in work-related vehicular accidents and in on-the-job accidents provided the data. Each accident was analyzed to determine whether or not the accident occurred on a biorhythmically…

  13. Generalized optical code construction for enhanced and Modified Double Weight like codes without mapping for SAC-OCDMA systems

    NASA Astrophysics Data System (ADS)

    Kumawat, Soma; Ravi Kumar, M.

    2016-07-01

    Double Weight (DW) code family is one of the coding schemes proposed for Spectral Amplitude Coding-Optical Code Division Multiple Access (SAC-OCDMA) systems. Modified Double Weight (MDW) code for even weights and Enhanced Double Weight (EDW) code for odd weights are two algorithms extending the use of DW code for SAC-OCDMA systems. The above mentioned codes use mapping technique to provide codes for higher number of users. A new generalized algorithm to construct EDW and MDW like codes without mapping for any weight greater than 2 is proposed. A single code construction algorithm gives same length increment, Bit Error Rate (BER) calculation and other properties for all weights greater than 2. Algorithm first constructs a generalized basic matrix which is repeated in a different way to produce the codes for all users (different from mapping). The generalized code is analysed for BER using balanced detection and direct detection techniques.

  14. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature

    PubMed Central

    Yim, Brandom; Gabig, Theodore G.

    2016-01-01

    We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities.

  15. Acoustic communication in the Greater Sage-Grouse (Centrocercus urophasianus) an examination into vocal sacs, sound propagation, and signal directionality

    NASA Astrophysics Data System (ADS)

    Dantzker, Marc Steven

    The thesis is an inquiry into the acoustic communication of a very unusual avian species, the Greater Sage-Grouse, Centrocercus urophasianus. One of the most outstanding features of this animal's dynamic mating display is its use of paired air sacs that emerge explosively from an esophageal pouch. My first line of inquiry into this system is a review of the form and function of similar vocal apparatuses, collectively called vocal sacs, in birds. Next, with a combination of mathematical models and field measurements, My collaborator and I investigate the acoustic environment where the Greater Sage-Grouse display. The complexities of this acoustic environment are relevant both to the birds and to the subsequent examinations of the display's properties. Finally, my collaborators and I examine a cryptic component of the acoustic display --- directionality --- which we measured simultaneously from multiple locations around free moving grouse on their mating grounds.

  16. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature

    PubMed Central

    Yim, Brandom; Gabig, Theodore G.

    2016-01-01

    We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities. PMID:27672460

  17. Take time to smell the frogs: vocal sac glands of reed frogs (Anura: Hyperoliidae) contain species-specific chemical cocktails

    PubMed Central

    Starnberger, Iris; Poth, Dennis; Peram, Pardha Saradhi; Schulz, Stefan; Vences, Miguel; Knudsen, Jette; Barej, Michael F; Rödel, Mark-Oliver; Walzl, Manfred; Hödl, Walter

    2013-01-01

    Males of all reed frog species (Anura: Hyperoliidae) have a prominent, often colourful, gular patch on their vocal sac, which is particularly conspicuous once the vocal sac is inflated. Although the presence, shape, and form of the gular patch are well-known diagnostic characters for these frogs, its function remains unknown. By integrating biochemical and histological methods, we found strong evidence that the gular patch is a gland producing volatile compounds, which might be emitted while calling. Volatile compounds were confirmed by gas chromatography–mass spectrometry in the gular glands in 11 species of the hyperoliid genera Afrixalus, Heterixalus, Hyperolius, and Phlyctimantis. Comparing the gular gland contents of 17 specimens of four sympatric Hyperolius species yielded a large variety of 65 compounds in species-specific combinations. We suggest that reed frogs might use a complex combination of at least acoustic and chemical signals in species recognition and mate choice. PMID:24277973

  18. Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature.

    PubMed

    Zarrabi, Kevin; Desai, Ved; Yim, Brandom; Gabig, Theodore G

    2016-01-01

    We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities. PMID:27672460

  19. Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension

    NASA Astrophysics Data System (ADS)

    Alonso, Rodrigo; Goller, Franz; Mindlin, Gabriel B.

    2014-03-01

    Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing tonal sounds such as domestic canaries (Serinus canaria), frequency modulation is determined by both the syringeal tension and the air sac pressure. For different models, we describe the structure of the isofrequency curves, which are sets of parameters leading to sounds presenting the same fundamental frequencies. We show how their shapes determine the relative roles of syringeal tension and air sac pressure in frequency modulation. Finally, we report experiments that allow us to unveil the features of the isofrequency curves.

  20. Fairy Chemicals, 2-Azahypoxanthine and 2-Aza-8-oxohypoxanthine, Regulate Carotenoid Accumulation in Citrus Juice Sacs in Vitro.

    PubMed

    Ma, Gang; Zhang, Lancui; Yamawaki, Kazuki; Yahata, Masaki; Choi, Jae-Hoon; Kawagishi, Hirokazu; Kato, Masaya

    2015-08-19

    "Fairy chemicals", 2-azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), are two novel plant-growth regulating compounds isolated from a fairy ring forming fungus, Lepista sordida. In the present study, the effects of AHX and AOH on the accumulation of carotenoids and expression of genes related to carotenoid metabolism were investigated in the juice sacs of Satsuma mandarin (Citrus unshiu Marc.) in vitro. The results showed that AHX and AOH regulated carotenoid metabolism in the citrus juice sacs. Carotenoid accumulation was induced by AHX in the second week and by AOH in the fourth week. In the meanwhile, the modification of carotenoid accumulation by the AHX and AOH treatments was highly regulated at the transcriptional level. The results presented herein provide new information on the functions of AHX and AOH in plants and contribute to elucidating the mechanisms by which AHX and AOH stimulate plant growth.