Cognitive functioning, subjective memory complaints and risky behaviour predict minor home injuries in elderly.

PubMed

Spano, Giuseppina; O Caffò, Alessandro; Bosco, Andrea

2017-11-27

Home accidents are one of the major causes of death, particularly in older people, young children and women. The first aim of this study was to explore the role of subjective memory complaints, cognitive functioning and risky behaviour as predictors of home injuries occurred in a year in a sample of healthy Italian older adults. The second aim was to investigate the role of risky behaviour as a mediator in the relationship between subjective and objective cognitive functioning and home injuries. One hundred thirty-three community-dwelling older people from southern Italy were administered a battery of tests to evaluate cognitive functioning, subjective memory complaints, and risky behaviour during home activities. Risky behaviour was evaluated using the Domestic Behaviour Questionnaire, created specifically for this purpose. The number of home injuries was recorded for a year throughout monthly telephone interviews. A path analysis was performed to test the following model: cognitive functioning and subjective memory complaints directly influence risky behaviour and number of accidents over a year; risky behaviour mediates the impact of cognitive functioning and subjective memory on number of accidents over a year. Path analysis confirmed the model tested except the role of risky behaviour as a mediator between cognitive functioning and home accidents. Risky behaviour could represent a further risk factor in cognitively intact older adults with subjective memory complaints. The assessment of both cognition and behaviour in elderly can make a valuable contribution in preventing home accidents in elderly.

Use of artificial intelligence in severe accident diagnosis for PWRs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Zheng; Okrent, D.; Kastenberg, W.E.

1995-12-31

A combination approach of an expert system and neural networks is used to implement a prototype severe accident diagnostic system which would monitor the progression of the severe accident and provide necessary plant status information to assist the plant staff in accident management during the accident. The station blackout accident in a pressurized water reactor (PWR) is used as the study case. The current phase of research focus is on distinguishing different primary system failure modes and following the accident transient before and up to vessel breach.

The potential of clustering methods to define intersection test scenarios: Assessing real-life performance of AEB.

PubMed

Sander, Ulrich; Lubbe, Nils

2018-04-01

Intersection accidents are frequent and harmful. The accident types 'straight crossing path' (SCP), 'left turn across path - oncoming direction' (LTAP/OD), and 'left-turn across path - lateral direction' (LTAP/LD) represent around 95% of all intersection accidents and one-third of all police-reported car-to-car accidents in Germany. The European New Car Assessment Program (Euro NCAP) have announced that intersection scenarios will be included in their rating from 2020; however, how these scenarios are to be tested has not been defined. This study investigates whether clustering methods can be used to identify a small number of test scenarios sufficiently representative of the accident dataset to evaluate Intersection Automated Emergency Braking (AEB). Data from the German In-Depth Accident Study (GIDAS) and the GIDAS-based Pre-Crash Matrix (PCM) from 1999 to 2016, containing 784 SCP and 453 LTAP/OD accidents, were analyzed with principal component methods to identify variables that account for the relevant total variances of the sample. Three different methods for data clustering were applied to each of the accident types, two similarity-based approaches, namely Hierarchical Clustering (HC) and Partitioning Around Medoids (PAM), and the probability-based Latent Class Clustering (LCC). The optimum number of clusters was derived for HC and PAM with the silhouette method. The PAM algorithm was both initiated with random start medoid selection and medoids from HC. For LCC, the Bayesian Information Criterion (BIC) was used to determine the optimal number of clusters. Test scenarios were defined from optimal cluster medoids weighted by their real-life representation in GIDAS. The set of variables for clustering was further varied to investigate the influence of variable type and character. We quantified how accurately each cluster variation represents real-life AEB performance using pre-crash simulations with PCM data and a generic algorithm for AEB intervention. The usage of different sets of clustering variables resulted in substantially different numbers of clusters. The stability of the resulting clusters increased with prioritization of categorical over continuous variables. For each different set of cluster variables, a strong in-cluster variance of avoided versus non-avoided accidents for the specified Intersection AEB was present. The medoids did not predict the most common Intersection AEB behavior in each cluster. Despite thorough analysis using various cluster methods and variable sets, it was impossible to reduce the diversity of intersection accidents into a set of test scenarios without compromising the ability to predict real-life performance of Intersection AEB. Although this does not imply that other methods cannot succeed, it was observed that small changes in the definition of a scenario resulted in a different avoidance outcome. Therefore, we suggest using limited physical testing to validate more extensive virtual simulations to evaluate vehicle safety. Copyright © 2018 Elsevier Ltd. All rights reserved.

Nuclear reactor safety research since three mile island.

PubMed

Mynatt, F R

1982-04-09

The Three Mile Island nuclear power plant accident has resulted in redirection of reactor safety research priorities. The small release to the environment of radioactive iodine-13 to 17 curies in a total radioactivity release of 2.4 million to 13 million curies-has led to a new emphasis on the physical chemistry of fission product behavior in accidents; the fact that the nuclear core was severely damaged but did not melt down has opened a new accident regime-that of the degraded core; the role of the operators in the progression and severity of the accident has shifted emphasis from equipment reliability to human reliability. As research progresses in these areas, the technical base for regulation and risk analysis will change substantially.

Workflow interruptions, cognitive failure and near-accidents in health care.

PubMed

Elfering, Achim; Grebner, Simone; Ebener, Corinne

2015-01-01

Errors are frequent in health care. A specific model was tested that affirms failure in cognitive action regulation to mediate the influence of nurses' workflow interruptions and safety conscientiousness on near-accidents in health care. One hundred and sixty-five nurses from seven Swiss hospitals participated in a questionnaire survey. Structural equation modelling confirmed the hypothesised mediation model. Cognitive failure in action regulation significantly mediated the influence of workflow interruptions on near-accidents (p < .05). An indirect path from conscientiousness to near-accidents via cognitive failure in action regulation was also significant (p < .05). Compliance with safety regulations was significantly related to cognitive failure and near-accidents; moreover, cognitive failure mediated the association between compliance and near-accidents (p < .05). Contrary to expectations, compliance with safety regulations was not related to workflow interruptions. Workflow interruptions caused by colleagues, patients and organisational constraints are likely to trigger errors in nursing. Work redesign is recommended to reduce cognitive failure and improve safety of nurses and patients.

The relationships between organizational and individual variables to on-the-job driver accidents and accident-free kilometres.

PubMed

Caird, J K; Kline, T J

2004-12-01

Highway fatalities are the leading cause of fatal work injuries in the US, accounting for approximately 1 in 4 of the 5900 job-related deaths during 2001. The present study focused on the contribution of organizational factors and driver behaviours to on-the-job driving accidents in a large Western Canadian corporation. A structural equation modelling (SEM) approach was used which allows researchers to test a complex set of relationships within a global theoretical framework. A number of scales were used to assess organizational support, driver errors, and driver behaviours. The sample of professional drivers that participated allowed the recording of on-the-job accidents and accident-free kilometres from their personnel files. The pattern of relationships in the fitted model, after controlling for exposure and social desirability, provides insight into the role of organizational support, planning, environment adaptations, fatigue, speed, errors and moving citations to on-the-job accidents and accident-free kilometres. For example, organizational support affected the capacity to plan. Time to plan work-related driving was found to predict accidents, fatigue and adaptations to the environment. Other interesting model paths, SEM limitations, future research and recommendations are elaborated.

Investigation and Implementation of Commercially Available Optically Stimulated Luminescence Dosimeters for Use in Fixed Nuclear Accident Dosimeter Systems.

PubMed

Georgeson, David L; Christiansen, Byron H

2018-06-01

Idaho National Laboratory transitioned from an external dosimetry system reliant on thermoluminescent dosimeters to one that uses optically stimulated luminescence dosimeters in 2010. This change not only affected the dosimeters worn by personnel, but those found in the nuclear-accident dosimeters used across Idaho National Laboratory. The elimination of on-site use and processing of thermoluminescent dosimeters impacted Idaho National Laboratory's ability to process nuclear-accident dosimeters in a timely manner. This change in processes drove Idaho National Laboratory to develop an alternative method for fixed nuclear-accident dosimeter gamma-dose analyses. This new method was driven by the need to establish a simple, cost-effective, and rapid-turnaround alternative to the thermoluminescent-dosimeter-based fixed nuclear-accident dosimeter system. An adaptation of existing technologies proved to be the most efficient path to this end. The purpose of this article is to delineate the technical basis for replacing the thermoluminescent dosimeter contained within the Idaho National Laboratory fixed nuclear-accident dosimeter system with optically stimulated luminescence-based Landauer, Inc., nanoDot dosimeters.

Research subjects for analytical estimation of core degradation at Fukushima-Daiichi nuclear power plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagase, F.; Ishikawa, J.; Kurata, M.

2013-07-01

Estimation of the accident progress and status inside the pressure vessels (RPV) and primary containment vessels (PCV) is required for appropriate conductance of decommissioning in the Fukushima-Daiichi NPP. For that, it is necessary to obtain additional experimental data and revised models for the estimation using computer codes with increased accuracies. The Japan Atomic Energy Agency (JAEA) has selected phenomena to be reviewed and developed, considering previously obtained information, conditions specific to the Fukushima-Daiichi NPP accident, and recent progress of experimental and analytical technologies. As a result, research and development items have been picked up in terms of thermal-hydraulic behavior inmore » the RPV and PCV, progression of fuel bundle degradation, failure of the lower head of RPV, and analysis of the accident. This paper introduces the selected phenomena to be reviewed and developed, research plans and recent results from the JAEA's corresponding research programs. (authors)« less

Development and application of the dynamic system doctor to nuclear reactor probabilistic risk assessments.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kunsman, David Marvin; Aldemir, Tunc; Rutt, Benjamin

2008-05-01

This LDRD project has produced a tool that makes probabilistic risk assessments (PRAs) of nuclear reactors - analyses which are very resource intensive - more efficient. PRAs of nuclear reactors are being increasingly relied on by the United States Nuclear Regulatory Commission (U.S.N.R.C.) for licensing decisions for current and advanced reactors. Yet, PRAs are produced much as they were 20 years ago. The work here applied a modern systems analysis technique to the accident progression analysis portion of the PRA; the technique was a system-independent multi-task computer driver routine. Initially, the objective of the work was to fuse the accidentmore » progression event tree (APET) portion of a PRA to the dynamic system doctor (DSD) created by Ohio State University. Instead, during the initial efforts, it was found that the DSD could be linked directly to a detailed accident progression phenomenological simulation code - the type on which APET construction and analysis relies, albeit indirectly - and thereby directly create and analyze the APET. The expanded DSD computational architecture and infrastructure that was created during this effort is called ADAPT (Analysis of Dynamic Accident Progression Trees). ADAPT is a system software infrastructure that supports execution and analysis of multiple dynamic event-tree simulations on distributed environments. A simulator abstraction layer was developed, and a generic driver was implemented for executing simulators on a distributed environment. As a demonstration of the use of the methodological tool, ADAPT was applied to quantify the likelihood of competing accident progression pathways occurring for a particular accident scenario in a particular reactor type using MELCOR, an integrated severe accident analysis code developed at Sandia. (ADAPT was intentionally created with flexibility, however, and is not limited to interacting with only one code. With minor coding changes to input files, ADAPT can be linked to other such codes.) The results of this demonstration indicate that the approach can significantly reduce the resources required for Level 2 PRAs. From the phenomenological viewpoint, ADAPT can also treat the associated epistemic and aleatory uncertainties. This methodology can also be used for analyses of other complex systems. Any complex system can be analyzed using ADAPT if the workings of that system can be displayed as an event tree, there is a computer code that simulates how those events could progress, and that simulator code has switches to turn on and off system events, phenomena, etc. Using and applying ADAPT to particular problems is not human independent. While the human resources for the creation and analysis of the accident progression are significantly decreased, knowledgeable analysts are still necessary for a given project to apply ADAPT successfully. This research and development effort has met its original goals and then exceeded them.« less

Major Accidents (Gray Swans) Likelihood Modeling Using Accident Precursors and Approximate Reasoning.

PubMed

Khakzad, Nima; Khan, Faisal; Amyotte, Paul

2015-07-01

Compared to the remarkable progress in risk analysis of normal accidents, the risk analysis of major accidents has not been so well-established, partly due to the complexity of such accidents and partly due to low probabilities involved. The issue of low probabilities normally arises from the scarcity of major accidents' relevant data since such accidents are few and far between. In this work, knowing that major accidents are frequently preceded by accident precursors, a novel precursor-based methodology has been developed for likelihood modeling of major accidents in critical infrastructures based on a unique combination of accident precursor data, information theory, and approximate reasoning. For this purpose, we have introduced an innovative application of information analysis to identify the most informative near accident of a major accident. The observed data of the near accident were then used to establish predictive scenarios to foresee the occurrence of the major accident. We verified the methodology using offshore blowouts in the Gulf of Mexico, and then demonstrated its application to dam breaches in the United Sates. © 2015 Society for Risk Analysis.

BNL severe-accident sequence experiments and analysis program. [PWR; BWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greene, G.A.; Ginsberg, T.; Tutu, N.K.

1983-01-01

In the analysis of degraded core accidents, the two major sources of pressure loading on light water reactor containments are: steam generation from core debris-water thermal interactions; and molten core-concrete interactions. Experiments are in progress at BNL in support of analytical model development related to aspects of the above containment loading mechanisms. The work supports development and evaluation of the CORCON (Muir, 1981) and MARCH (Wooton, 1980) computer codes. Progress in the two programs is described.

Traffic accidents in Iran, a decade of progress but still challenges ahead.

PubMed

Lankarani, Kamran B; Sarikhani, Yaser; Heydari, Seyed Taghi; Joulaie, Hasan; Maharlouei, Najmeh; Peimani, Payam; Ahmadi, Seyed Mehdi; Khorasani-Zavareh, Davoud; Soori, Hamid; Davoudi-Kiakalayeh, Ali; Masoumi, Gholamreza

2014-01-01

Iran has had incremental incidence of traffic accident mortality since introduction of mechanization about a century ago. But the newest data from Iran show decrease in the absolute number of deaths, death per 10,000 vehicles and death per 100, 000 populations. Despite its huge impact on health and economy, research in the field of traffic crashes is still scant and there are still deficiencies in problem oriented research on traffic accidents. Actual cooperation of policy makers, executive bodies and academician could build platform for intersectoral discussion of different aspects of traffic accidents and could reduce burden of traffic accidents.

Progress to extinction: increased specialisation causes the demise of animal clades.

PubMed

Raia, P; Carotenuto, F; Mondanaro, A; Castiglione, S; Passaro, F; Saggese, F; Melchionna, M; Serio, C; Alessio, L; Silvestro, D; Fortelius, M

2016-08-10

Animal clades tend to follow a predictable path of waxing and waning during their existence, regardless of their total species richness or geographic coverage. Clades begin small and undifferentiated, then expand to a peak in diversity and range, only to shift into a rarely broken decline towards extinction. While this trajectory is now well documented and broadly recognised, the reasons underlying it remain obscure. In particular, it is unknown why clade extinction is universal and occurs with such surprising regularity. Current explanations for paleontological extinctions call on the growing costs of biological interactions, geological accidents, evolutionary traps, and mass extinctions. While these are effective causes of extinction, they mainly apply to species, not clades. Although mass extinctions is the undeniable cause for the demise of a sizeable number of major taxa, we show here that clades escaping them go extinct because of the widespread tendency of evolution to produce increasingly specialised, sympatric, and geographically restricted species over time.

Progress to extinction: increased specialisation causes the demise of animal clades

NASA Astrophysics Data System (ADS)

Raia, P.; Carotenuto, F.; Mondanaro, A.; Castiglione, S.; Passaro, F.; Saggese, F.; Melchionna, M.; Serio, C.; Alessio, L.; Silvestro, D.; Fortelius, M.

2016-08-01

Animal clades tend to follow a predictable path of waxing and waning during their existence, regardless of their total species richness or geographic coverage. Clades begin small and undifferentiated, then expand to a peak in diversity and range, only to shift into a rarely broken decline towards extinction. While this trajectory is now well documented and broadly recognised, the reasons underlying it remain obscure. In particular, it is unknown why clade extinction is universal and occurs with such surprising regularity. Current explanations for paleontological extinctions call on the growing costs of biological interactions, geological accidents, evolutionary traps, and mass extinctions. While these are effective causes of extinction, they mainly apply to species, not clades. Although mass extinctions is the undeniable cause for the demise of a sizeable number of major taxa, we show here that clades escaping them go extinct because of the widespread tendency of evolution to produce increasingly specialised, sympatric, and geographically restricted species over time.

Fall-related accidents among hikers in the Austrian Alps: a 9-year retrospective study

PubMed Central

Faulhaber, Martin; Pocecco, Elena; Ruedl, Gerhard; Walter, Dagmar; Sterr, Regina; Ebner, Hans; Schobersberger, Wolfgang; Burtscher, Martin

2017-01-01

Objective To analyse the circumstances of fatal and non-fatal mountain hiking accidents caused by falls. Methods The study was designed as a retrospective analysis. Mountain hiking accidents caused by falls were documented during a 9-year period (2006–2014). After screening of all data for potential exclusion criteria the final sample size of 5368 accidents and 5665 victims was included into the analyses. Main outcome measures were details about accidents, victims, type of trail and surface. Results The annual number of accidents showed a continuous increase from 467 in 2006 to 700 in 2014. In total, 5.8% of all victims died during the 9-year period. 75.3% of the hikers fell during descent and 80.9% of the victims had their accident on a marked hiking trail or small path. The sex ratio for non-fatal accidents was 55% female and 45% male; for fatal accidents the female-to-male ratio was 28%:72%. Mean age of all victims was 52.5±17.5 years and victims of fatalities were about 5 years older compared with victims of non-fatal accidents (57.5±16.5 vs 52.2±17.5 years, P<0.01). Conclusion Descent is the most risky part for accidents caused by falls during mountain hiking. Male hikers are at greater risk for fatalities independent of age and this is associated with accidents occurring in pathless terrain. The death rate from falls was 6%. We recommend a critical self-assessment of the individual capabilities and mountain hiking skills and adequate planning of the hiking tours for mountain hikers. PMID:29259815

GIS-based accident location and analysis system (GIS-ALAS) : project report : phase I

DOT National Transportation Integrated Search

1998-04-06

This report summarizes progress made in Phase I of the geographic information system (GIS) based Accident Location and Analysis System (GIS-ALAS). The GIS-ALAS project builds on PC-ALAS, a locationally-referenced highway crash database query system d...

ATWS at Browns Ferry Unit One - accident sequence analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, R.M.; Hodge, S.A.

1984-07-01

This study describes the predicted response of Unit One at the Browns Ferry Nuclear Plant to a postulated complete failure to scram following a transient occurrence that has caused closure of all Main Steam Isolation Valves (MSIVs). This hypothetical event constitutes the most severe example of the type of accident classified as Anticipated Transient Without Scram (ATWS). Without the automatic control rod insertion provided by scram, the void coefficient of reactivity and the mechanisms by which voids are formed in the moderator/coolant play a dominant role in the progression of the accident. Actions taken by the operator greatly influence themore » quantity of voids in the coolant and the effect is analyzed in this report. The progression of the accident sequence under existing and under recommended procedures is discussed. For the extremely unlikely cases in which equipment failure and wrongful operator actions might lead to severe core damage, the sequence of emergency action levels and the associated timing of events are presented.« less

Flying qualities criteria for GA single pilot IFR operations

NASA Technical Reports Server (NTRS)

Bar-Gill, A.

1982-01-01

The flying qualities criteria in general aviation (GA) to decrease accidents are discussed. The following in-flight research is discussed: (1) identification of key aerodynamic configurations; (2) implementation of an in-flight simulator; (3) mission matrix design; (4) experimental systems; (5) data reduction; (6) optimal flight path reconstruction. Some of the accomplished work is reported: an integrated flight testing and flight path reconstruction methodology was developd, high accuracy in trajectory estimation was achieved with an experimental setup, and a part of the flight test series was flown.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rempe, Joy; Farmer, Mitchell; Corradini, Michael

The Three Mile Island Unit 2 (TMI-2) accident, which occurred on March 28, 1979, led industry and regulators to enhance strategies to protect against severe accidents in commercial nuclear power plants. Investigations in the years after the accident concluded that at least 45% of the core had melted and that nearly 19 tonnes of the core material had relocated to the lower head. Postaccident examinations indicate that about half of that material formed a solid layer near the lower head and above it was a layer of fragmented rubble. As discussed in this paper, numerous insights related to pressurized watermore » reactor accident progression were gained from postaccident evaluations of debris, reactor pressure vessel (RPV) specimens, and nozzles taken from the RPV. In addition, information gleaned from TMI-2 specimen evaluations and available data from plant instrumentation were used to improve severe accident simulation models that form the technical basis for reactor safety evaluations. Finally, the TMI-2 accident led the nuclear community to dedicate considerable effort toward understanding severe accident phenomenology as well as the potential for containment failure. Because available data suggest that significant amounts of fuel heated to temperatures near melting, the events at Fukushima Daiichi Units 1, 2, and 3 offer an unexpected opportunity to gain similar understanding about boiling water reactor accident progression. To increase the international benefit from such an endeavor, we recommend that an international effort be initiated to (a) prioritize data needs; (b) identify techniques, samples, and sample evaluations needed to address each information need; and (c) help finance acquisition of the required data and conduct of the analyses.« less

Comparative analysis of PA-31-350 Chieftain (N44LV) accident and NASA crash test data

NASA Technical Reports Server (NTRS)

Hayduk, R. J.

1979-01-01

A full scale, controlled crash test to simulate the crash of a Piper PA-31-350 Chieftain airplane is described. Comparisons were performed between the simulated crash and the actual crash in order to assess seat and floor behavior, and to estimate the acceleration levels experienced in the craft at the time of impact. Photographs, acceleration histories, and the tested airplane crash data is used to augment the accident information to better define the crash conditions. Measured impact parameters are presented along with flight path velocity and angle in relation to the impact surface.

US Efforts in Support of Examinations at Fukushima Daiichi – 2016 Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amway, P.; Andrews, N.; Bixby, Willis

Although it is clear that the accident signatures from each unit at the Fukushima Daiichi Nuclear Power Station (NPS) [Daiichi] differ, much is not known about the end-state of core materials within these units. Some of this uncertainty can be attributed to a lack of information related to cooling system operation and cooling water injection. There is also uncertainty in our understanding of phenomena affecting: a) in-vessel core damage progression during severe accidents in boiling water reactors (BWRs), and b) accident progression after vessel failure (ex-vessel progression) for BWRs and Pressurized Water Reactors (PWRs). These uncertainties arise due to limitedmore » full scale prototypic data. Similar to what occurred after the accident at Three Mile Island Unit 2, these Daiichi units offer the international community a means to reduce such uncertainties by obtaining prototypic data from multiple full-scale BWR severe accidents. Information obtained from Daiichi is required to inform Decontamination and Decommissioning activities, improving the ability of the Tokyo Electric Power Company Holdings (TEPCO) to characterize potential hazards and to ensure the safety of workers involved with cleanup activities. This document reports recent results from the US Forensics Effort to use information obtained by TEPCO to enhance the safety of existing and future nuclear power plant designs. This Forensics Effort, which is sponsored by the Reactor Safety Technologies Pathway of the Department of Energy Office of Nuclear Energy Light Water Reactor (LWR) Sustainability Program, consists of a group of US experts in LWR safety and plant operations that have identified examination needs and are evaluating TEPCO information from Daiichi that address these needs. Examples presented in this report demonstrate that significant safety insights are being obtained in the areas of component performance, fission product release and transport, debris end-state location, and combustible gas generation and transport. In addition to reducing uncertainties related to severe accident modeling progression, these insights are being used to update guidance for severe accident prevention, mitigation, and emergency planning. Furthermore, reduced uncertainties in modeling the events at Daiichi will improve the realism of reactor safety evaluations and inform future D&D activities by improving the capability for characterizing potential hazards to workers involved with cleanup activities.« less

[Implementation of safety devices: biological accident prevention].

PubMed

Catalán Gómez, M Teresa; Sol Vidiella, Josep; Castellà Castellà, Manel; Castells Bo, Carolina; Losada Pla, Nuria; Espuny, Javier Lluís

2010-04-01

Accidental exposures to blood and biological material were the most frequent and potentially serious accidents in healthcare workers, reported in the Prevention of Occupational Risks Unit within 2002. Evaluate the biological percutaneous accidents decrease after a progressive introduction of safety devices. Biological accidents produced between 2.002 and 2.006 were analyzed and reported by the injured healthcare workers to the Level 2b Hospital Prevention of Occupational Risk Unit with 238 beds and 750 employees. The key of the study was the safety devices (peripheral i.v. catheter, needleless i.v. access device and capillary blood collection lancet). Within 2002, 54 percutaneous biological accidents were registered and 19 in 2006, that represents a 64.8% decreased. There has been no safety devices accident reported involving these material. Accidents registered during the implantation period occurred because safety devices were not used at that time. Safety devices have proven to be effective in reducing needle stick percutaneous accidents, so that they are a good choice in the primary prevention of biological accidents contact.

The Viareggio LPG railway accident: event reconstruction and modeling.

PubMed

Brambilla, Sara; Manca, Davide

2010-10-15

This manuscript describes in detail the LPG accident occurred in Viareggio on June 2009 and its modeling. The accident investigation highlighted the uncertainty and complexity of assessing and modeling what happened in the congested environment close to the Viareggio railway station. Nonetheless, the analysis allowed comprehending the sequence of events, the way they influenced each other, and the different possible paths/evolutions. The paper describes suitable models for the quantitative assessment of the consequences of the most probable accidental dynamics and its outcomes. The main finding is that after about 80 s from the beginning of the release the dense-gas cloud reached the surrounding houses that were destroyed successively by internal explosions. This fact has two main implications. First, it shows that the adopted modeling framework can give a correct picture of what happened in Viareggio. Second, it confirms the need to develop effective mitigation measures because, in case of this kind of accidents, there is no time to apply any protective emergency plans/actions. 2010 Elsevier B.V. All rights reserved.

Public Attitudes to Technological Progress.

ERIC Educational Resources Information Center

Marshall, Eliot

1979-01-01

Discusses the probable changes in public attitudes toward science and technology as a result of the engineering accidents of 1979. Results of national polls conducted to identify public confidence in technological progress are included. (HM)

Features of the Asynchronous Correlation between the China Coal Price Index and Coal Mining Accidental Deaths.

PubMed

Huang, Yuecheng; Cheng, Wuyi; Luo, Sida; Luo, Yun; Ma, Chengchen; He, Tailin

2016-01-01

The features of the asynchronous correlation between accident indices and the factors that influence accidents can provide an effective reference for warnings of coal mining accidents. However, what are the features of this correlation? To answer this question, data from the China coal price index and the number of deaths from coal mining accidents were selected as the sample data. The fluctuation modes of the asynchronous correlation between the two data sets were defined according to the asynchronous correlation coefficients, symbolization, and sliding windows. We then built several directed and weighted network models, within which the fluctuation modes and the transformations between modes were represented by nodes and edges. Then, the features of the asynchronous correlation between these two variables could be studied from a perspective of network topology. We found that the correlation between the price index and the accidental deaths was asynchronous and fluctuating. Certain aspects, such as the key fluctuation modes, the subgroups characteristics, the transmission medium, the periodicity and transmission path length in the network, were analyzed by using complex network theory, analytical methods and spectral analysis method. These results provide a scientific reference for generating warnings for coal mining accidents based on economic indices.

Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation

NASA Technical Reports Server (NTRS)

Grantier, David

2003-01-01

This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

Reducing health care hazards: lessons from the commercial aviation safety team.

PubMed

Pronovost, Peter J; Goeschel, Christine A; Olsen, Kyle L; Pham, Julius C; Miller, Marlene R; Berenholtz, Sean M; Sexton, J Bryan; Marsteller, Jill A; Morlock, Laura L; Wu, Albert W; Loeb, Jerod M; Clancy, Carolyn M

2009-01-01

The movement to improve quality of care and patient safety has grown, but examples of measurable and sustained progress are rare. The slow progress made in health care contrasts with the success of aviation safety. After a tragic 1995 plane crash, the aviation industry and government created the Commercial Aviation Safety Team to reduce fatal accidents. This public-private partnership of safety officials and technical experts is responsible for the decreased average rate of fatal aviation accidents. We propose a similar partnership in the health care community to coordinate national efforts and move patient safety and quality forward.

MELCOR simulations of the severe accident at Fukushima Daiichi Unit 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardoni, Jeffrey; Gauntt, Randall; Kalinich, Donald

In response to the accident at the Fukushima Daiichi nuclear power station in Japan, the U.S. Nuclear Regulatory Commission and U.S. Department of Energy agreed to jointly sponsor an accident reconstruction study as a means of assessing the severe accident modeling capability of the MELCOR code. Objectives of the project included reconstruction of the accident progressions using computer models and accident data, and validation of the MELCOR code and the Fukushima models against plant data. A MELCOR 2.1 model of the Fukushima Daiichi Unit 3 reactor is developed using plant-specific information and accident-specific boundary conditions, which involve considerable uncertainty duemore » to the inherent nature of severe accidents. Publicly available thermal-hydraulic data and radioactivity release estimates have evolved significantly since the accidents. Such data are expected to continually change as the reactors are decommissioned and more measurements are performed. As a result, the MELCOR simulations in this work primarily use boundary conditions that are based on available plant data as of May 2012.« less

MELCOR simulations of the severe accident at Fukushima Daiichi Unit 3

DOE PAGES

Cardoni, Jeffrey; Gauntt, Randall; Kalinich, Donald; ...

2014-05-01

In response to the accident at the Fukushima Daiichi nuclear power station in Japan, the U.S. Nuclear Regulatory Commission and U.S. Department of Energy agreed to jointly sponsor an accident reconstruction study as a means of assessing the severe accident modeling capability of the MELCOR code. Objectives of the project included reconstruction of the accident progressions using computer models and accident data, and validation of the MELCOR code and the Fukushima models against plant data. A MELCOR 2.1 model of the Fukushima Daiichi Unit 3 reactor is developed using plant-specific information and accident-specific boundary conditions, which involve considerable uncertainty duemore » to the inherent nature of severe accidents. Publicly available thermal-hydraulic data and radioactivity release estimates have evolved significantly since the accidents. Such data are expected to continually change as the reactors are decommissioned and more measurements are performed. As a result, the MELCOR simulations in this work primarily use boundary conditions that are based on available plant data as of May 2012.« less

Do failures in non-technical skills contribute to fatal medical accidents in Japan? A review of the 2010–2013 national accident reports

PubMed Central

Uramatsu, Masashi; Fujisawa, Yoshikazu; Mizuno, Shinya; Souma, Takahiro; Komatsubara, Akinori; Miki, Tamotsu

2017-01-01

Objectives We sought to clarify how large a proportion of fatal medical accidents can be considered to be caused by poor non-technical skills, and to support development of a policy to reduce number of such accidents by making recommendations about possible training requirements. Design Summaries of reports of fatal medical accidents, published by the Japan Medical Safety Research Organization, were reviewed individually. Three experienced clinicians and one patient safety expert conducted the reviews to determine the cause of death. Views of the patient safety expert were given additional weight in the overall determination. Setting A total of 73 summary reports of fatal medical accidents were reviewed. These reports had been submitted by healthcare organisations across Japan to the Japan Medical Safety Research Organization between April 2010 and March 2013. Primary and secondary outcome measures The cause of death in fatal medical accidents, categorised into technical skills, non-technical skills and inevitable progress of disease were evaluated. Non-technical skills were further subdivided into situation awareness, decision making, communication, team working, leadership, managing stress and coping with fatigue. Results Overall, the cause of death was identified as non-technical skills in 34 cases (46.6%), disease progression in 33 cases (45.2%) and technical skills in two cases (5.5%). In two cases, no consensual determination could be achieved. Further categorisation of cases of non-technical skills were identified as 14 cases (41.2%) of problems with situation awareness, eight (23.5%) with team working and three (8.8%) with decision making. These three subcategories, or combinations of them, were identified as the cause of death in 33 cases (97.1%). Conclusions Poor non-technical skills were considered to be a significant cause of adverse events in nearly half of the fatal medical accidents examined. Improving non-technical skills may be effective for reducing accidents, and training in particular subcategories of non-technical skills may be especially relevant. PMID:28209605

Learning lessons from Natech accidents - the eNATECH accident database

NASA Astrophysics Data System (ADS)

Krausmann, Elisabeth; Girgin, Serkan

2016-04-01

When natural hazards impact industrial facilities that house or process hazardous materials, fires, explosions and toxic releases can occur. This type of accident is commonly referred to as Natech accident. In order to prevent the recurrence of accidents or to better mitigate their consequences, lessons-learned type studies using available accident data are usually carried out. Through post-accident analysis, conclusions can be drawn on the most common damage and failure modes and hazmat release paths, particularly vulnerable storage and process equipment, and the hazardous materials most commonly involved in these types of accidents. These analyses also lend themselves to identifying technical and organisational risk-reduction measures that require improvement or are missing. Industrial accident databases are commonly used for retrieving sets of Natech accident case histories for further analysis. These databases contain accident data from the open literature, government authorities or in-company sources. The quality of reported information is not uniform and exhibits different levels of detail and accuracy. This is due to the difficulty of finding qualified information sources, especially in situations where accident reporting by the industry or by authorities is not compulsory, e.g. when spill quantities are below the reporting threshold. Data collection has then to rely on voluntary record keeping often by non-experts. The level of detail is particularly non-uniform for Natech accident data depending on whether the consequences of the Natech event were major or minor, and whether comprehensive information was available for reporting. In addition to the reporting bias towards high-consequence events, industrial accident databases frequently lack information on the severity of the triggering natural hazard, as well as on failure modes that led to the hazmat release. This makes it difficult to reconstruct the dynamics of the accident and renders the development of equipment vulnerability models linking the natural-hazard severity to the observed damage almost impossible. As a consequence, the European Commission has set up the eNATECH database for the systematic collection of Natech accident data and near misses. The database exhibits the more sophisticated accident representation required to capture the characteristics of Natech events and is publicly accessible at http://enatech.jrc.ec.europa.eu. This presentation outlines the general lessons-learning process, introduces the eNATECH database and its specific structure, and discusses natural-hazard specific lessons learned and features common to Natech accidents triggered by different natural hazards.

Effects of the Fukushima Daiichi nuclear accident on goshawk reproduction

PubMed Central

Murase, Kaori; Murase, Joe; Horie, Reiko; Endo, Koichi

2015-01-01

Although the influence of nuclear accidents on the reproduction of top predators has not been investigated, it is important that we identify the effects of such accidents because humans are also top predators. We conducted field observation for 22 years and analysed the reproductive performance of the goshawk (Accipiter gentilis fujiyamae), a top avian predator in the North Kanto area of Japan, before and after the accidents at the Fukushima Daiichi nuclear power plant that occurred in 2011. The reproductive performance declined markedly compared with the pre-accident years and progressively decreased for the three post-accident study years. Moreover, it was suggested that these declines were primarily caused by an increase in the air dose rate of radio-active contaminants measured under the nests caused by the nuclear accidents, rather than by other factors. We consider the trends in the changes of the reproductive success rates and suggest that internal exposure may play an important role in the reproductive performance of the goshawk, as well as external exposure. PMID:25802117

Effects of the Fukushima Daiichi nuclear accident on goshawk reproduction.

PubMed

Murase, Kaori; Murase, Joe; Horie, Reiko; Endo, Koichi

2015-03-24

Although the influence of nuclear accidents on the reproduction of top predators has not been investigated, it is important that we identify the effects of such accidents because humans are also top predators. We conducted field observation for 22 years and analysed the reproductive performance of the goshawk (Accipiter gentilis fujiyamae), a top avian predator in the North Kanto area of Japan, before and after the accidents at the Fukushima Daiichi nuclear power plant that occurred in 2011. The reproductive performance declined markedly compared with the pre-accident years and progressively decreased for the three post-accident study years. Moreover, it was suggested that these declines were primarily caused by an increase in the air dose rate of radio-active contaminants measured under the nests caused by the nuclear accidents, rather than by other factors. We consider the trends in the changes of the reproductive success rates and suggest that internal exposure may play an important role in the reproductive performance of the goshawk, as well as external exposure.

Optimization of aeromedical base locations in New Mexico using a model that considers crash nodes and paths.

PubMed

Erdemir, Elif Tokar; Batta, Rajan; Spielman, Seth; Rogerson, Peter A; Blatt, Alan; Flanigan, Marie

2008-05-01

In a recent paper, Tokar Erdemir et al. (2008) introduce models for service systems with service requests originating from both nodes and paths. We demonstrate how to apply and extend their approach to an aeromedical base location application, with specific focus on the state of New Mexico (NM). The current aeromedical base locations of NM are selected without considering motor vehicle crash paths. Crash paths are the roads on which crashes occur, where each road segment has a weight signifying relative crash occurrence. We analyze the loss in accident coverage and location error for current aeromedical base locations. We also provide insights on the relevance of considering crash paths when selecting aeromedical base locations. Additionally, we look briefly at some of the tradeoff issues in locating additional trauma centers vs. additional aeromedical bases in the current aeromedical system of NM. Not surprisingly, tradeoff analysis shows that by locating additional aeromedical bases, we always attain the required coverage level with a lower cost than with locating additional trauma centers.

Lessons Learned Through the Follow-up of the Long-Term Effects of Over-Exposure to an Ir192 Industrial Radiography Source in Bangladesh

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jalil, A.; Rabbani, G.; Hossain, M. K.

2003-02-24

An industrial radiographer was accidentally over-exposed while taking the radiograph of weld-joints of gas pipe-lines in 1985 in Bangladesh. Symptoms of high radiation exposure occurred immediately after the accident and skin erythema developed leading to progressive tissue deterioration. The consequences of this over-exposure is being followed up to assess the long-term effects of ionizing radiation on the victim. Progressive tissue deteriorations have already led to multiple surgeries and successive amputations of the finger-tips so far. Lessons learned from this accident are also reported in this paper.

Energy absorption buildup factors, exposure buildup factors and Kerma for optically stimulated luminescence materials and their tissue equivalence for radiation dosimetry

NASA Astrophysics Data System (ADS)

Singh, Vishwanath P.; Badiger, N. M.

2014-11-01

Optically stimulated luminescence (OSL) materials are sensitive dosimetric materials used for precise and accurate dose measurement for low-energy ionizing radiation. Low dose measurement capability with improved sensitivity makes these dosimeters very useful for diagnostic imaging, personnel monitoring and environmental radiation dosimetry. Gamma ray energy absorption buildup factors and exposure build factors were computed for OSL materials using the five-parameter Geometric Progression (G-P) fitting method in the energy range 0.015-15 MeV for penetration depths up to 40 mean free path. The computed energy absorption buildup factor and exposure buildup factor values were studied as a function of penetration depth and incident photon energy. Effective atomic numbers and Kerma relative to air of the selected OSL materials and tissue equivalence were computed and compared with that of water, PMMA and ICRU standard tissues. The buildup factors and kerma relative to air were found dependent upon effective atomic numbers. Buildup factors determined in the present work should be useful in radiation dosimetry, medical diagnostics and therapy, space dosimetry, accident dosimetry and personnel monitoring.

Features of the Asynchronous Correlation between the China Coal Price Index and Coal Mining Accidental Deaths

PubMed Central

Huang, Yuecheng; Cheng, Wuyi; Luo, Sida; Luo, Yun; Ma, Chengchen; He, Tailin

2016-01-01

The features of the asynchronous correlation between accident indices and the factors that influence accidents can provide an effective reference for warnings of coal mining accidents. However, what are the features of this correlation? To answer this question, data from the China coal price index and the number of deaths from coal mining accidents were selected as the sample data. The fluctuation modes of the asynchronous correlation between the two data sets were defined according to the asynchronous correlation coefficients, symbolization, and sliding windows. We then built several directed and weighted network models, within which the fluctuation modes and the transformations between modes were represented by nodes and edges. Then, the features of the asynchronous correlation between these two variables could be studied from a perspective of network topology. We found that the correlation between the price index and the accidental deaths was asynchronous and fluctuating. Certain aspects, such as the key fluctuation modes, the subgroups characteristics, the transmission medium, the periodicity and transmission path length in the network, were analyzed by using complex network theory, analytical methods and spectral analysis method. These results provide a scientific reference for generating warnings for coal mining accidents based on economic indices. PMID:27902748

Progress towards understanding and predicting convection heat transfer in the turbine gas path

NASA Technical Reports Server (NTRS)

Simoneau, Robert J.; Simon, Frederick F.

1992-01-01

A new era is drawing in the ability to predict convection heat transfer in the turbine gas path. We feel that the technical community now has the capability to mount a major assault on this problem, which has eluded significant progress for a long time. We hope to make a case for this bold statement by reviewing the state of the art in three major heat transfer, configuration-specific experiments, whose data have provided the big picture and guided both the fundamental modeling research and the code development. Following that, we review progress and directions in the development of computer codes to predict turbine gas path heat transfer. Finally, we cite examples and make observations on the more recent efforts to do all this work in a simultaneous, interactive, and more synergistic manner. We conclude with an assessment of progress, suggestions for how to use the current state of the art, and recommendations for the future.

Inseparability of science history and discovery

NASA Astrophysics Data System (ADS)

Herndon, J. M.

2010-04-01

Science is very much a logical progression through time. Progressing along a logical path of discovery is rather like following a path through the wilderness. Occasionally the path splits, presenting a choice; the correct logical interpretation leads to further progress, the wrong choice leads to confusion. By considering deeply the relevant science history, one might begin to recognize past faltering in the logical progression of observations and ideas and, perhaps then, to discover new, more precise understanding. The following specific examples of science faltering are described from a historical perspective: (1) Composition of the Earth's inner core; (2) Giant planet internal energy production; (3) Physical impossibility of Earth-core convection and Earth-mantle convection, and; (4) Thermonuclear ignition of stars. For each example, a revised logical progression is described, leading, respectively, to: (1) Understanding the endo-Earth's composition; (2) The concept of nuclear georeactor origin of geo- and planetary magnetic fields; (3) The invalidation and replacement of plate tectonics; and, (4) Understanding the basis for the observed distribution of luminous stars in galaxies. These revised logical progressions clearly show the inseparability of science history and discovery. A different and more fundamental approach to making scientific discoveries than the frequently discussed variants of the scientific method is this: An individual ponders and through tedious efforts arranges seemingly unrelated observations into a logical sequence in the mind so that causal relationships become evident and new understanding emerges, showing the path for new observations, for new experiments, for new theoretical considerations, and for new discoveries. Science history is rich in "seemingly unrelated observations" just waiting to be logically and causally related to reveal new discoveries.

Insight from Fukushima Daiichi Unit 3 Investigations using MELCOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.; Francis, Matthew W.; Ott, Larry J.

During the emergency response period of the accidents that took place at Fukushima Daiichi in March of 2011, researchers at Oak Ridge National Laboratory (ORNL) conducted a number of studies using the MELCOR code to help understand what was occurring and what had occurred. During the post-accident period, the Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC) jointly sponsored a study of the Fukushima Daiichi accident with collaboration among Oak Ridge, Sandia, and Idaho national laboratories. The purpose of the study was to compile relevant data, reconstruct the accident progression using computer codes, assess the codes predictivemore » capabilities, and identify future data needs. The current paper summarizes some of the early MELCOR simulations and analyses conducted at ORNL of the Fukushima Daiichi Unit 3 accident. Extended analysis and discussion of the Unit 3 accident is also presented taking into account new knowledge and modeling refinements made since the joint DOE/NRC study.« less

Continuously improving safety of nuclear installations: An approach to be reinforced after the Fukushima accident

NASA Astrophysics Data System (ADS)

Repussard, Jacques; Schwarz, Michel

2012-05-01

After the Three Mile Island accident in 1979 and the Chernobyl accident in 1986, the Fukushima accident shows that the probability of a core meltdown accident in an LWR (Light Water Reactor) has been largely underestimated. The consequences of such an accident are unacceptable: except in the case of TMI2 (Three Mile Island 2) large areas around the damaged plants are contaminated for decades and populations have to be relocated for long periods. This article presents the French approach which consists in improving continuously the safety of the Nuclear Power Plants (NPP) on the basis of lessons learned from operating experience and from the progress in R&D (Research and Development). It details the key role played by IRSN (Institut de radioprotection et de sûreté nucléaire), the French TSO (Technical and scientific Safety Organization), and shows how the Fukushima accident contributes to this approach in improving NPP robustness. It concludes on the necessity to keep on networking TSOs, to share knowledge as well as R&D resources, with the ultimate goal of enhancing and harmonizing nuclear safety worldwide.

Do failures in non-technical skills contribute to fatal medical accidents in Japan? A review of the 2010-2013 national accident reports.

PubMed

Uramatsu, Masashi; Fujisawa, Yoshikazu; Mizuno, Shinya; Souma, Takahiro; Komatsubara, Akinori; Miki, Tamotsu

2017-02-16

We sought to clarify how large a proportion of fatal medical accidents can be considered to be caused by poor non-technical skills, and to support development of a policy to reduce number of such accidents by making recommendations about possible training requirements. Summaries of reports of fatal medical accidents, published by the Japan Medical Safety Research Organization, were reviewed individually. Three experienced clinicians and one patient safety expert conducted the reviews to determine the cause of death. Views of the patient safety expert were given additional weight in the overall determination. A total of 73 summary reports of fatal medical accidents were reviewed. These reports had been submitted by healthcare organisations across Japan to the Japan Medical Safety Research Organization between April 2010 and March 2013. The cause of death in fatal medical accidents, categorised into technical skills, non-technical skills and inevitable progress of disease were evaluated. Non-technical skills were further subdivided into situation awareness, decision making, communication, team working, leadership, managing stress and coping with fatigue. Overall, the cause of death was identified as non-technical skills in 34 cases (46.6%), disease progression in 33 cases (45.2%) and technical skills in two cases (5.5%). In two cases, no consensual determination could be achieved. Further categorisation of cases of non-technical skills were identified as 14 cases (41.2%) of problems with situation awareness, eight (23.5%) with team working and three (8.8%) with decision making. These three subcategories, or combinations of them, were identified as the cause of death in 33 cases (97.1%). Poor non-technical skills were considered to be a significant cause of adverse events in nearly half of the fatal medical accidents examined. Improving non-technical skills may be effective for reducing accidents, and training in particular subcategories of non-technical skills may be especially relevant. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Historic avalanches in the northern front range and the central and northern mountains of Colorado

Treesearch

M. Martinelli; Charles F. Leaf

1999-01-01

Newspaper accounts of avalanche accidents from the 1860s through 1950 have been compiled, summarized, and discussed. Many of the avalanches that caused fatalities came down rather small, innocuous-looking paths. Land use planners can use historical avalanche information as a reminder of the power of snow avalanches and to assure rational development in the future....

In-Flight Decision-Making by General Aviation Pilots Operating in Areas of Extreme Thunderstorms.

PubMed

Boyd, Douglas D

2017-12-01

General aviation (comprised mainly of noncommercial, light aircraft) accounts for 94% of civil aviation fatalities in the United States. Although thunderstorms are hazardous to light aircraft, little research has been undertaken on in-flight pilot decision-making regarding their avoidance. The study objectives were: 1) to determine if the thunderstorm accident rate has declined over the last two decades; and 2) assess in-flight (enroute/landing) airman decision-making regarding adherence to FAA separation minima from thunderstorms. Thunderstorm-related accidents were identified from the NTSB database. To determine en route/arriving aircraft real-time thunderstorm proximity/relative position and airplane location, using a flight-tracking (Flight Aware®) website, were overlaid on a graphical weather image. Statistics employed Poisson and Chi-squared analyses. The thunderstorm-related accident rate was undiminished over the 1996-2014 period. In a prospective analysis the majority (enroute 77%, landing 93%) of flights violated the FAA-recommended separation distance from extreme convection. Of these, 79 and 69% (en route and landing, respectively) selected a route downwind of the thunderstorm rather than a less hazardous upwind flight path. Using a mathematical product of binary (separation distance, relative aircraft-thunderstorm position) and nominal (thunderstorm-free egress area) parameters, airmen were more likely to operate in the thunderstorm hazard zone for landings than en route operations. The thunderstorm-related accident rate, carrying a 70% fatality rate, remains unabated, largely reflecting nonadherence to the FAA-recommended separation minima and selection of a more hazardous route (downwind) for circumnavigation of extreme convective weather. These findings argue for additional emphasis in ab initio pilot training/recurrency on thunderstorm hazards and safe practices (separation distance and flight path).Boyd DD. In-flight decision-making by general aviation pilots operating in areas of extreme thunderstorms. Aerosp Med Hum Perform. 2017; 88(12):1066-1072.

Emergency relief venting of the infrared telescope liquid helium dewar, second edition

NASA Technical Reports Server (NTRS)

Urban, E. W.

1981-01-01

An updated analysis is made of the emergency relief venting of the liquid helium dewar of the Spacelab 2 Infrared Telescope experiment in the event of a massive failure of the dewar guard vacuum. Such a failure, resulting from a major accident, could cause rapid heating and pressurization of the liquid helium in the dewar and lead to relief venting through the emergency relief system. The heat input from an accident is estimated for various fluid conditions in the dewar and the relief process considered as it takes place through one or both of the emergency relief paths. It was previously assumed that the burst diaphragms in the dewar relief paths would rupture at a pressure of 65 psi differential or 4.4 atmospheres. In fact, it has proved necessary to use burst diaphragms in the dewar which rupture at 115 psid or 7.8 atmospheres. An analysis of this case was carried out and shows that when the high pressure diaphragm rupture occurs, the dewar pressure falls within 8 s to below the 4.4 atmospheres for which the original analysis was performed, and thereafter it remains below that level.

Modeling of Individual and Organizational Factors Affecting Traumatic Occupational Injuries Based on the Structural Equation Modeling: A Case Study in Large Construction Industries.

PubMed

Mohammadfam, Iraj; Soltanzadeh, Ahmad; Moghimbeigi, Abbas; Akbarzadeh, Mehdi

2016-09-01

Individual and organizational factors are the factors influencing traumatic occupational injuries. The aim of the present study was the short path analysis of the severity of occupational injuries based on individual and organizational factors. The present cross-sectional analytical study was implemented on traumatic occupational injuries within a ten-year timeframe in 13 large Iranian construction industries. Modeling and data analysis were done using the structural equation modeling (SEM) approach and the IBM SPSS AMOS statistical software version 22.0, respectively. The mean age and working experience of the injured workers were 28.03 ± 5.33 and 4.53 ± 3.82 years, respectively. The portions of construction and installation activities of traumatic occupational injuries were 64.4% and 18.1%, respectively. The SEM findings showed that the individual, organizational and accident type factors significantly were considered as effective factors on occupational injuries' severity (P < 0.05). Path analysis of occupational injuries based on the SEM reveals that individual and organizational factors and their indicator variables are very influential on the severity of traumatic occupational injuries. So, these should be considered to reduce occupational accidents' severity in large construction industries.

Organisational Factors of Occupational Accidents with Movement Disturbance (OAMD) and Prevention

PubMed Central

LECLERCQ, Sylvie

2014-01-01

Workplace design and upkeep, or human factors, are frequently advanced for explaining so-called Occupational Slip, Trip and Fall Accidents (OSTFAs). Despite scientific progress, these accidents, and more broadly Occupational Accidents with Movement Disturbance (OAMDs), are also commonly considered to be “simple”. This paper aims to stimulate changes in such perceptions by focusing on organisational factors that often combine with other accident factors to cause movement disturbance and injury in work situations. These factors frequently lead to arbitration between production and safety, which involves implementation of controls by workers. These controls can lead to greater worker exposure to OAMD risk. We propose a model that focuses on such controls to account specifically for the need to confront production and safety logics within a company and to enhance the potential for appropriate prevention action. These are then integrated into the set of controls highlighted by work organisation model developed by the NIOSH. PMID:25345425

Fukushima Daiichi Unit 1 Uncertainty Analysis-Exploration of Core Melt Progression Uncertain Parameters-Volume II.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Denman, Matthew R.; Brooks, Dusty Marie

Sandia National Laboratories (SNL) has conducted an uncertainty analysi s (UA) on the Fukushima Daiichi unit (1F1) accident progression wit h the MELCOR code. Volume I of the 1F1 UA discusses the physical modeling details and time history results of the UA. Volume II of the 1F1 UA discusses the statistical viewpoint. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). The goal of this work was to perform a focused evaluation of uncertainty in core damage progression behavior and its effect on keymore » figures - of - merit (e.g., hydrogen production, fraction of intact fuel, vessel lower head failure) and in doing so assess the applicability of traditional sensitivity analysis techniques .« less

Categorizing accident sequences in the external radiotherapy for risk analysis

PubMed Central

2013-01-01

Purpose This study identifies accident sequences from the past accidents in order to help the risk analysis application to the external radiotherapy. Materials and Methods This study reviews 59 accidental cases in two retrospective safety analyses that have collected the incidents in the external radiotherapy extensively. Two accident analysis reports that accumulated past incidents are investigated to identify accident sequences including initiating events, failure of safety measures, and consequences. This study classifies the accidents by the treatments stages and sources of errors for initiating events, types of failures in the safety measures, and types of undesirable consequences and the number of affected patients. Then, the accident sequences are grouped into several categories on the basis of similarity of progression. As a result, these cases can be categorized into 14 groups of accident sequence. Results The result indicates that risk analysis needs to pay attention to not only the planning stage, but also the calibration stage that is committed prior to the main treatment process. It also shows that human error is the largest contributor to initiating events as well as to the failure of safety measures. This study also illustrates an event tree analysis for an accident sequence initiated in the calibration. Conclusion This study is expected to provide sights into the accident sequences for the prospective risk analysis through the review of experiences. PMID:23865005

Implementation of the Vehicle Black Box Using External Sensor and Networks

NASA Astrophysics Data System (ADS)

Back, Sung-Hyun; Kim, Jang-Ju; Kim, Mi-Jin; Kim, Hwa-Sun; Park, You-Sin; Jang, Jong-Wook

With the increasing uses of black boxes for vehicles, they are being widely studied and developed. Existing black boxes store only video and sound, and have limitations in accurately identifying accident contexts. Besides, data are lost if the black box in the vehicle is damaged. In this study, a smart black box was manufactured by storing the additional data, including on the tire pressure, in-vehicle data (e.g., head lamp operation), current location, travel path and speed, and video and sound, using OBD-II and GPS to improve the efficiency and accuracy of accident analysis. An external storage device was used for data backup via wireless LAN to allow checking of data even when the black box is damaged.

[A singular bullet run in a firearm wound in the neck. A case report].

PubMed

Martino, Antonio; De Rienzo, Dino; Evangelista, Marco; La Rocca, Francesco; Maharajan, Gautam; Martino, Giovanni; Sacco, Maria Lucia; Scaglione, Mariano

2009-01-01

The paper deals with the peculiarities of a firearm wound regarding the dynamic of the accident and particularly considering the path followed by the bullet. The patient's firearm wound is described on the basis of the instrumental examinations done. These last give us a precious help to confirm the thesis, already guessed on the clinical examination of an introduction and path followed through the digestive tract, and to show the dynamics and the still positions of the bullet inside the patient's body. The bullet was expelled spontaneously by defecation. After control of no internal damages this firearm wound has been treated simply as a normal tip wound.

Science as a Model for Rational, Legitimate Government

NASA Astrophysics Data System (ADS)

Branscomb, Lewis

2009-05-01

Before WWII science was largely dependent on support through teaching, and a few foundations. In the last half century, thanks to the contribution of applied science to winning the second world war, government became a deep-pockets source of support for science. While many academic scientists were deeply suspicious of government as a sponsor, the research universities saw an opportunity to build their institutions around government support. Government saw science as a means for sustaining its military primacy. Thus a marriage was consummated by partners -- science and politics -- who needed each other, but for quite different and to some degree conflicting motives. In the U.S. democracy, the relationship between science and politics has never been easy. The search for truth in science and for legitimacy in politics both require systems for generating public trust, but these systems are not the same, and indeed they are often incompatible. The most profound area of mismatch between science and politics is found not in conflicts over what kinds of research are deserving of public funding, but rather in conflicts over the advice government receives from scientific and technical experts. It is no accident that democratic America fostered progress in science and technology. Both American democracy and modern science are products of the Enlightenment, with its emphasis on reason and openness rather than on prejudice and traditional authority. American democracy has always benefited from a pragmatic willingness to learn from experience, very much as science relies on experiment. Progress in science is based transparency and accountability; these are also basic principles of democratic government. If science is corrupted by government, government itself is in danger of becoming corrupt. In recent years we seemed to be going down that path. It is no accident that President Obama and media commentators speak often of the ``new pragmatism,'' or that he appointed exceptionally well-qualified scientists to top posts in his government. Both democracy and science stand to benefit enormously when our political leaders understand that the ethos of science and ethics of democracy have common roots.

Critical factors and paths influencing construction workers' safety risk tolerances.

PubMed

Wang, Jiayuan; Zou, Patrick X W; Li, Penny P

2016-08-01

While workers' safety risk tolerances have been regarded as a main reason for their unsafe behaviors, little is known about why different people have different risk tolerances even when confronting the same situation. The aim of this research is to identify the critical factors and paths that influence workers' safety risk tolerance and to explore how they contribute to accident causal model from a system thinking perceptive. A number of methods were carried out to analyze the data collected through interviews and questionnaire surveys. In the first and second steps of the research, factor identification, factor ranking and factor analysis were carried out, and the results show that workers' safety risk tolerance can be influenced by four groups of factors, namely: (1) personal subjective perception; (2) work knowledge and experiences; (3) work characteristics; and (4) safety management. In the third step of the research, hypothetical influencing path model was developed and tested by using structural equation modeling (SEM). It is found that the effects of external factors (safety management and work characteristics) on risk tolerance are larger than that of internal factors (personal subjective perception and work knowledge & experiences). Specifically, safety management contributes the most to workers' safety risk tolerance through its direct effect and indirect effect; while personal subjective perception comes the second and can act as an intermedia for work characteristics. This research provides an in-depth insight of workers' unsafe behaviors by depicting the contributing factors as shown in the accident causal model developed in this research. Copyright © 2015 Elsevier Ltd. All rights reserved.

Elucidating the ensemble of functionally-relevant transitions in protein systems with a robotics-inspired method.

PubMed

Molloy, Kevin; Shehu, Amarda

2013-01-01

Many proteins tune their biological function by transitioning between different functional states, effectively acting as dynamic molecular machines. Detailed structural characterization of transition trajectories is central to understanding the relationship between protein dynamics and function. Computational approaches that build on the Molecular Dynamics framework are in principle able to model transition trajectories at great detail but also at considerable computational cost. Methods that delay consideration of dynamics and focus instead on elucidating energetically-credible conformational paths connecting two functionally-relevant structures provide a complementary approach. Effective sampling-based path planning methods originating in robotics have been recently proposed to produce conformational paths. These methods largely model short peptides or address large proteins by simplifying conformational space. We propose a robotics-inspired method that connects two given structures of a protein by sampling conformational paths. The method focuses on small- to medium-size proteins, efficiently modeling structural deformations through the use of the molecular fragment replacement technique. In particular, the method grows a tree in conformational space rooted at the start structure, steering the tree to a goal region defined around the goal structure. We investigate various bias schemes over a progress coordinate for balance between coverage of conformational space and progress towards the goal. A geometric projection layer promotes path diversity. A reactive temperature scheme allows sampling of rare paths that cross energy barriers. Experiments are conducted on small- to medium-size proteins of length up to 214 amino acids and with multiple known functionally-relevant states, some of which are more than 13Å apart of each-other. Analysis reveals that the method effectively obtains conformational paths connecting structural states that are significantly different. A detailed analysis on the depth and breadth of the tree suggests that a soft global bias over the progress coordinate enhances sampling and results in higher path diversity. The explicit geometric projection layer that biases the exploration away from over-sampled regions further increases coverage, often improving proximity to the goal by forcing the exploration to find new paths. The reactive temperature scheme is shown effective in increasing path diversity, particularly in difficult structural transitions with known high-energy barriers.

Assessing flight safety differences between the United States regional and major airlines

NASA Astrophysics Data System (ADS)

Sharp, Broderick H.

During 2008, the U.S. domestic airline departures exceeded 28,000 flights per day. Thirty-nine or less than 0.2 of 1% of these flights resulted in operational incidents or accidents. However, even a low percentage of airline accidents and incidents continue to cause human suffering and property loss. The charge of this study was the comparison of U.S. major and regional airline safety histories. The study spans safety events from January 1982 through December 2008. In this quantitative analysis, domestic major and regional airlines were statistically tested for their flight safety differences. Four major airlines and thirty-seven regional airlines qualified for the safety study which compared the airline groups' fatal accidents, incidents, non-fatal accidents, pilot errors, and the remaining six safety event probable cause types. The six other probable cause types are mechanical failure, weather, air traffic control, maintenance, other, and unknown causes. The National Transportation Safety Board investigated each airline safety event, and assigned a probable cause to each event. A sample of 500 events was randomly selected from the 1,391 airlines' accident and incident population. The airline groups' safety event probabilities were estimated using the least squares linear regression. A probability significance level of 5% was chosen to conclude the appropriate research question hypothesis. The airline fatal accidents and incidents probability levels were 1.2% and 0.05% respectively. These two research questions did not reach the 5% significance level threshold. Therefore, the airline groups' fatal accidents and non-destructive incidents probabilities favored the airline groups' safety differences hypothesis. The linear progression estimates for the remaining three research questions were 71.5% for non-fatal accidents, 21.8% for the pilot errors, and 7.4% significance level for the six probable causes. These research questions' linear regressions are greater than the 5% level. Consequently, these three research questions favored airline groups' safety similarities hypothesis. The study indicates the U.S. domestic major airlines were safer than the regional airlines. Ideas for potential airline safety progress can examine pilot fatigue, the airline groups' hiring policies, the government's airline oversight personnel, or the comparison of individual airline's operational policies.

A passively-safe fusion reactor blanket with helium coolant and steel structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crosswait, Kenneth Mitchell

1994-04-01

Helium is attractive for use as a fusion blanket coolant for a number of reasons. It is neutronically and chemically inert, nonmagnetic, and will not change phase during any off-normal or accident condition. A significant disadvantage of helium, however, is its low density and volumetric heat capacity. This disadvantage manifests itself most clearly during undercooling accident conditions such as a loss of coolant accident (LOCA) or a loss of flow accident (LOFA). This thesis describes a new helium-cooled tritium breeding blanket concept which performs significantly better during such accidents than current designs. The proposed blanket uses reduced-activation ferritic steel asmore » a structural material and is designed for neutron wall loads exceeding 4 MW/m{sup 2}. The proposed geometry is based on the nested-shell concept developed by Wong, but some novel features are used to reduce the severity of the first wall temperature excursion. These features include the following: (1) A ``beryllium-joint`` concept is introduced, which allows solid beryllium slabs to be used as a thermal conduction path from the first wall to the cooler portions of the blanket. The joint concept allows for significant swelling of the beryllium (10 percent or more) without developing large stresses in the blanket structure. (2) Natural circulation of the coolant in the water-cooled shield is used to maintain shield temperatures below 100 degrees C, thus maintaining a heat sink close to the blanket during the accident. This ensures the long-term passive safety of the blanket.« less

National and regional analysis of road accidents in Spain.

PubMed

Tolón-Becerra, A; Lastra-Bravo, X; Flores-Parra, I

2013-01-01

In Spain, the absolute fatality figures decreased almost 50 percent between 1998 and 2009. Despite this great effort, road mortality is still of great concern to political authorities. Further progress requires efficient road safety policy based on an optimal set of measures and targets that consider the initial conditions and characteristics in each region. This study attempts to analyze road accidents in Spain and its provinces in time and space during 1998-2009. First, we analyzed daily, monthly, and nationwide (NUTS 0) development of road accidents, the correlation between logarithmic transformations of road accidents and territorial and socioeconomic variables, the causality by simple linear regression of road accidents and territorial and socioeconomic variables, and preliminary frequency by fast Fourier transform. Then we analyzed the annual trend in accidents in the Spanish provinces (NUTS 3) and found a correlation between the logarithmic transformations of the mortality rate, fatalities per fatal accident, and accidents resulting in injuries per inhabitant variables and population, population density, gross domestic product (GDP), length of road network, and area. Finally, causality was analyzed by simple linear regression. The most outstanding results were the negative correlation between mortality rate and population density in Spanish provinces, which has increased over time, and that road accidents in Spain have an approximate periodicity of 57 days. The fast Fourier transform analysis of road accident frequency in Spain was useful in identifying the periodic, harmonic components of accidents and casualties. The periodicity observed both for the period 1998-2009 and by year showed that the highest intensity in road accidents was bimonthly, despite the lower number of accidents and casualties in the spectra of amplitude and power and efforts to reduce the intensity and concentration during off-season travel (summer and December).

Andy Gump Fracture of the Mandible in a Pediatric Patient.

PubMed

Mulinari-Santos, Gabriel; Lima, Valthierre Nunes; Palacio-Muñoz, Xiomara Mónica Johanna; Oliva, André Hergesel de; Momesso, Gustavo Antonio Correa; Polo, Tárik Ocon Braga; Souza, Francisley Ávila; Garcia-Júnior, Idelmo Rangel; Faverani, Leonardo Perez

2017-10-01

The mandibular fractures in pediatric patients are rare, and they can need a fast and safe treatment. We present a case of a pediatric patient with "Andy Gump" fracture, resulting in a retrognathic mandible, distress to breathe, and functional discomfort to the patient caused by a cycling accident. The treatment was successful with the fast release of airway path and use of titanium plates to fix the fracture.

Longitudinal study of appraisal at Three Mile Island: implications for life event research.

PubMed

Goldsteen, R; Schorr, J K; Goldsteen, K S

1989-01-01

This study tests a path model which indicates the occurrence of appraisal following the accident at Three Mile Island (TMI). The model posits a causal relationship between trust in TMI-related authorities, perceived danger, perceived harm to health, and psychological distress. The implications of the findings for life event research are discussed in terms of the etiological significance of meaning, event consequences, and control.

Collision avoidance using neural networks

NASA Astrophysics Data System (ADS)

Sugathan, Shilpa; Sowmya Shree, B. V.; Warrier, Mithila R.; Vidhyapathi, C. M.

2017-11-01

Now a days, accidents on roads are caused due to the negligence of drivers and pedestrians or due to unexpected obstacles that come into the vehicle’s path. In this paper, a model (robot) is developed to assist drivers for a smooth travel without accidents. It reacts to the real time obstacles on the four critical sides of the vehicle and takes necessary action. The sensor used for detecting the obstacle was an IR proximity sensor. A single layer perceptron neural network is used to train and test all possible combinations of sensors result by using Matlab (offline). A microcontroller (ARM Cortex-M3 LPC1768) is used to control the vehicle through the output data which is received from Matlab via serial communication. Hence, the vehicle becomes capable of reacting to any combination of real time obstacles.

Transcription and replication: breaking the rules of the road causes genomic instability.

PubMed

Poveda, Ana Maria; Le Clech, Mikael; Pasero, Philippe

2010-01-01

Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blocking fork progression and could be implicated in the development of cancer.

Opportunities and limitations for intersection collision intervention-A study of real world 'left turn across path' accidents.

PubMed

Sander, Ulrich

2017-02-01

Turning across the path of oncoming vehicle accidents are frequent and dangerous. To date not many car manufacturers have introduced Automated Emergency Braking (AEB) systems addressing this type of conflict situation, but it is foreseeable that these scenarios will be part of the Euro NCAP 2020 rating. Nine out of ten collisions are caused by the driver of the turning vehicle. An AEB system evaluating the ego and conflict vehicle driver's possibilities to avoid a pending crash by either braking or steering was specified for application in various constellations of vehicle collisions. In virtual simulation, AEB system parameters were varied, covering parameters that are relevant for driver comfort such as longitudinal and lateral acceleration (to define avoidance possibilities), expected steering maneuvers to avoid conflict, and intervention response characteristics (brake delay and ramp up) to assess the safety benefit. The reference simulation showed a potential of the AEB system in the turning vehicle to avoid approximately half of the collisions. An AEB system of the straight going vehicle was less effective. The effectiveness of the turning vehicle's AEB system increases if spatial limitations for the collision-avoidance steering maneuver are known. Such information could be provided by sensors detecting free space in or around the road environment or geographical information shared via vehicle to cloud communication. AEB interventions rarely result in collision avoidance for turning vehicles with speeds above 40km/h or for straight going vehicles with speeds above 60km/h. State of the art field-of-views of forward looking sensing systems designed for AEB rear-end interventions are capable of addressing turning across path situations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Risk factors for accident death in the U.S. Army, 2004-2009.

PubMed

Lewandowski-Romps, Lisa; Peterson, Christopher; Berglund, Patricia A; Collins, Stacey; Cox, Kenneth; Hauret, Keith; Jones, Bruce; Kessler, Ronald C; Mitchell, Colter; Park, Nansook; Schoenbaum, Michael; Stein, Murray B; Ursano, Robert J; Heeringa, Steven G

2014-12-01

Accidents are one of the leading causes of death among U.S. active-duty Army soldiers. Evidence-based approaches to injury prevention could be strengthened by adding person-level characteristics (e.g., demographics) to risk models tested on diverse soldier samples studied over time. To identify person-level risk indicators of accident deaths in Regular Army soldiers during a time frame of intense military operations, and to discriminate risk of not-line-of-duty from line-of-duty accident deaths. Administrative data acquired from multiple Army/Department of Defense sources for active duty Army soldiers during 2004-2009 were analyzed in 2013. Logistic regression modeling was used to identify person-level sociodemographic, service-related, occupational, and mental health predictors of accident deaths. Delayed rank progression or demotion and being male, unmarried, in a combat arms specialty, and of low rank/service length increased odds of accident death for enlisted soldiers. Unique to officers was high risk associated with aviation specialties. Accident death risk decreased over time for currently deployed, enlisted soldiers and increased for those never deployed. Mental health diagnosis was associated with risk only for previous and never-deployed, enlisted soldiers. Models did not discriminate not-line-of-duty from line-of-duty accident deaths. Adding more refined person-level and situational risk indicators to current models could enhance understanding of accident death risk specific to soldier rank and deployment status. Stable predictors could help identify high risk of accident deaths in future cohorts of Regular Army soldiers. Copyright © 2014 American Journal of Preventive Medicine. All rights reserved.

Risk Factors for Accident Death in the U.S. Army, 2004–2009

PubMed Central

Lewandowski-Romps, Lisa; Peterson, Christopher; Berglund, Patricia A.; Collins, Stacey; Cox, Kenneth; Hauret, Keith; Jones, Bruce; Kessler, Ronald C.; Mitchell, Colter; Park, Nansook; Schoenbaum, Michael; Stein, Murray B.; Ursano, Robert J.; Heeringa, Steven G.

2014-01-01

Background Accidents are one of the leading causes of death among U.S. active duty Army soldiers. Evidence-based approaches to injury prevention could be strengthened by adding person-level characteristics (e.g., demographics) to risk models tested on diverse soldier samples studied over time. Purpose To identify person-level risk indicators of accident deaths in Regular Army soldiers during a time frame of intense military operations, and to discriminate risk of not-line-of-duty (NLOD) from line-of-duty (LOD) accident deaths. Methods Administrative data acquired from multiple Army/Department of Defense sources for active duty Army soldiers during 2004–2009 were analyzed in 2013. Logistic regression modeling was used to identify person-level sociodemographic, service-related, occupational, and mental health predictors of accident deaths. Results Delayed rank progression or demotion and being male, unmarried, in a combat arms specialty, and of low rank/service length increased odds of accident death for enlisted soldiers. Unique to officers was high risk associated with aviation specialties. Accident death risk decreased over time for currently deployed, enlisted soldiers while increasing for those never deployed. Mental health diagnosis was associated with risk only for previous and never-deployed, enlisted soldiers. Models did not discriminate NLOD from LOD accident deaths. Conclusions Adding more refined person-level and situational risk indicators to current models could enhance understanding of accident death risk specific to soldier rank and deployment status. Stable predictors could help identify high risk of accident deaths in future cohorts of Regular Army soldiers. PMID:25441238

Light Water Reactor Sustainability Program Reactor Safety Technologies Pathway Technical Program Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corradini, M. L.; Peko, D.; Farmer, M.

In the aftermath of the March 2011 multi-unit accident at the Fukushima Daiichi nuclear power plant (Fukushima), the nuclear community has been reassessing certain safety assumptions about nuclear reactor plant design, operations and emergency actions, particularly with respect to extreme events that might occur and that are beyond each plant’s current design basis. Because of our significant domestic investment in nuclear reactor technology (99 operating reactors in the fleet of commercial LWRs with five under construction), the United States has been a major leader internationally in these activities. The U.S. nuclear industry is voluntarily pursuing a number of additional safetymore » initiatives. The NRC continues to evaluate and, where deemed appropriate, establish new requirements for ensuring adequate protection of public health and safety in the occurrence of low probability events at nuclear plants; (e.g., mitigation strategies for beyond design basis events initiated by external events like seismic or flooding initiators). The DOE has also played a major role in the U.S. response to the Fukushima accident. Initially, DOE worked with the Japanese and the international community to help develop a more complete understanding of the Fukushima accident progression and its consequences, and to respond to various safety concerns emerging from uncertainties about the nature of and the effects from the accident. DOE R&D activities are focused on providing scientific and technical insights, data, analyses methods that ultimately support industry efforts to enhance safety. These activities are expected to further enhance the safety performance of currently operating U.S. nuclear power plants as well as better characterize the safety performance of future U.S. plants. In pursuing this area of R&D, DOE recognizes that the commercial nuclear industry is ultimately responsible for the safe operation of licensed nuclear facilities. As such, industry is considered the primary “end user” of the results from this DOE-sponsored work. The response to the Fukushima accident has been global, and there is a continuing multinational interest in collaborations to better quantify accident consequences and to incorporate lessons learned from the accident. DOE will continue to seek opportunities to facilitate collaborations that are of value to the U.S. industry, particularly where the collaboration provides access to vital data from the accident or otherwise supports or leverages other important R&D work. The purpose of the Reactor Safety Technology R&D is to improve understanding of beyond design basis events and reduce uncertainty in severe accident progression, phenomenology, and outcomes using existing analytical codes and information gleaned from severe accidents, in particular the Fukushima Daiichi events. This information will be used to aid in developing mitigating strategies and improving severe accident management guidelines for the current light water reactor fleet.« less

Light Water Reactor Sustainability Program: Reactor Safety Technologies Pathway Technical Program Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corradini, M. L.

In the aftermath of the March 2011 multi-unit accident at the Fukushima Daiichi nuclear power plant (Fukushima), the nuclear community has been reassessing certain safety assumptions about nuclear reactor plant design, operations and emergency actions, particularly with respect to extreme events that might occur and that are beyond each plant’s current design basis. Because of our significant domestic investment in nuclear reactor technology (99 operating reactors in the fleet of commercial LWRs with five under construction), the United States has been a major leader internationally in these activities. The U.S. nuclear industry is voluntarily pursuing a number of additional safetymore » initiatives. The NRC continues to evaluate and, where deemed appropriate, establish new requirements for ensuring adequate protection of public health and safety in the occurrence of low probability events at nuclear plants; (e.g., mitigation strategies for beyond design basis events initiated by external events like seismic or flooding initiators). The DOE has also played a major role in the U.S. response to the Fukushima accident. Initially, DOE worked with the Japanese and the international community to help develop a more complete understanding of the Fukushima accident progression and its consequences, and to respond to various safety concerns emerging from uncertainties about the nature of and the effects from the accident. DOE R&D activities are focused on providing scientific and technical insights, data, analyses methods that ultimately support industry efforts to enhance safety. These activities are expected to further enhance the safety performance of currently operating U.S. nuclear power plants as well as better characterize the safety performance of future U.S. plants. In pursuing this area of R&D, DOE recognizes that the commercial nuclear industry is ultimately responsible for the safe operation of licensed nuclear facilities. As such, industry is considered the primary “end user” of the results from this DOE-sponsored work. The response to the Fukushima accident has been global, and there is a continuing multinational interest in collaborations to better quantify accident consequences and to incorporate lessons learned from the accident. DOE will continue to seek opportunities to facilitate collaborations that are of value to the U.S. industry, particularly where the collaboration provides access to vital data from the accident or otherwise supports or leverages other important R&D work. The purpose of the Reactor Safety Technology R&D is to improve understanding of beyond design basis events and reduce uncertainty in severe accident progression, phenomenology, and outcomes using existing analytical codes and information gleaned from severe accidents, in particular the Fukushima Daiichi events. This information will be used to aid in developing mitigating strategies and improving severe accident management guidelines for the current light water reactor fleet.« less

Elucidating the ensemble of functionally-relevant transitions in protein systems with a robotics-inspired method

PubMed Central

2013-01-01

Background Many proteins tune their biological function by transitioning between different functional states, effectively acting as dynamic molecular machines. Detailed structural characterization of transition trajectories is central to understanding the relationship between protein dynamics and function. Computational approaches that build on the Molecular Dynamics framework are in principle able to model transition trajectories at great detail but also at considerable computational cost. Methods that delay consideration of dynamics and focus instead on elucidating energetically-credible conformational paths connecting two functionally-relevant structures provide a complementary approach. Effective sampling-based path planning methods originating in robotics have been recently proposed to produce conformational paths. These methods largely model short peptides or address large proteins by simplifying conformational space. Methods We propose a robotics-inspired method that connects two given structures of a protein by sampling conformational paths. The method focuses on small- to medium-size proteins, efficiently modeling structural deformations through the use of the molecular fragment replacement technique. In particular, the method grows a tree in conformational space rooted at the start structure, steering the tree to a goal region defined around the goal structure. We investigate various bias schemes over a progress coordinate for balance between coverage of conformational space and progress towards the goal. A geometric projection layer promotes path diversity. A reactive temperature scheme allows sampling of rare paths that cross energy barriers. Results and conclusions Experiments are conducted on small- to medium-size proteins of length up to 214 amino acids and with multiple known functionally-relevant states, some of which are more than 13Å apart of each-other. Analysis reveals that the method effectively obtains conformational paths connecting structural states that are significantly different. A detailed analysis on the depth and breadth of the tree suggests that a soft global bias over the progress coordinate enhances sampling and results in higher path diversity. The explicit geometric projection layer that biases the exploration away from over-sampled regions further increases coverage, often improving proximity to the goal by forcing the exploration to find new paths. The reactive temperature scheme is shown effective in increasing path diversity, particularly in difficult structural transitions with known high-energy barriers. PMID:24565158

ADAPT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reynolds, John; Jankovsky, Zachary; Metzroth, Kyle G

2018-04-04

The purpose of the ADAPT code is to generate Dynamic Event Trees (DET) using a user specified set of simulators. ADAPT can utilize any simulation tool which meets a minimal set of requirements. ADAPT is based on the concept of DET which uses explicit modeling of the deterministic dynamic processes that take place during a nuclear reactor plant system (or other complex system) evolution along with stochastic modeling. When DET are used to model various aspects of Probabilistic Risk Assessment (PRA), all accident progression scenarios starting from an initiating event are considered simultaneously. The DET branching occurs at user specifiedmore » times and/or when an action is required by the system and/or the operator. These outcomes then decide how the dynamic system variables will evolve in time for each DET branch. Since two different outcomes at a DET branching may lead to completely different paths for system evolution, the next branching for these paths may occur not only at separate times, but can be based on different branching criteria. The computational infrastructure allows for flexibility in ADAPT to link with different system simulation codes, parallel processing of the scenarios under consideration, on-line scenario management (initiation as well as termination), analysis of results, and user friendly graphical capabilities. The ADAPT system is designed for a distributed computing environment; the scheduler can track multiple concurrent branches simultaneously. The scheduler is modularized so that the DET branching strategy can be modified (e.g. biasing towards the worst-case scenario/event). Independent database systems store data from the simulation tasks and the DET structure so that the event tree can be constructed and analyzed later. ADAPT is provided with a user-friendly client which can easily sort through and display the results of an experiment, precluding the need for the user to manually inspect individual simulator runs.« less

Environmental accident and its treatment in a developing country: a case study on China.

PubMed

Hou, Yu

2012-08-01

Along with their rapid progress, developing countries have had to deal with more environmental problems, which have been a cause for concern among policy makers and the public in general. This study cites two accidents that happened in China in 2006 that caused serious environmental problems in nearby communities and discusses the problems these accidents created and the resulting disputes among the concerned people. Pollution-causing accidents not only pose threats to the health of the victims but also give rise to environmental disputes that jeopardise national security and social stability. Conflicts normally ensue following a pollution-causing accident, which are more likely to happen within a development zone or industrial park. Few environmental conflicts in the past decades were resolved through litigation. Nevertheless, there are lapses in the regulatory system, which have to be addressed to ensure that the public's rights and interests are protected. Currently, reports on pollution-causing accidents are difficult to obtain and are often released very late. A majority of industrial firms operate without environmental clearance, thus highlighting the government's inefficiency in environmental management. It is about time that the Chinese government takes seriously the use of the Environmental Impact Assessment.

Extracting recurrent scenarios from narrative texts using a Bayesian network: application to serious occupational accidents with movement disturbance.

PubMed

Abdat, F; Leclercq, S; Cuny, X; Tissot, C

2014-09-01

A probabilistic approach has been developed to extract recurrent serious Occupational Accident with Movement Disturbance (OAMD) scenarios from narrative texts within a prevention framework. Relevant data extracted from 143 accounts was initially coded as logical combinations of generic accident factors. A Bayesian Network (BN)-based model was then built for OAMDs using these data and expert knowledge. A data clustering process was subsequently performed to group the OAMDs into similar classes from generic factor occurrence and pattern standpoints. Finally, the Most Probable Explanation (MPE) was evaluated and identified as the associated recurrent scenario for each class. Using this approach, 8 scenarios were extracted to describe 143 OAMDs in the construction and metallurgy sectors. Their recurrent nature is discussed. Probable generic factor combinations provide a fair representation of particularly serious OAMDs, as described in narrative texts. This work represents a real contribution to raising company awareness of the variety of circumstances, in which these accidents occur, to progressing in the prevention of such accidents and to developing an analysis framework dedicated to this kind of accident. Copyright © 2014 Elsevier Ltd. All rights reserved.

Learning from Automation Surprises and "Going Sour" Accidents: Progress on Human-Centered Automation

NASA Technical Reports Server (NTRS)

Woods, David D.; Sarter, Nadine B.

1998-01-01

Advances in technology and new levels of automation on commercial jet transports has had many effects. There have been positive effects from both an economic and a safety point of view. The technology changes on the flight deck also have had reverberating effects on many other aspects of the aviation system and different aspects of human performance. Operational experience, research investigations, incidents, and occasionally accidents have shown that new and sometimes surprising problems have arisen as well. What are these problems with cockpit automation, and what should we learn from them? Do they represent over-automation or human error? Or instead perhaps there is a third possibility - they represent coordination breakdowns between operators and the automation? Are the problems just a series of small independent glitches revealed by specific accidents or near misses? Do these glitches represent a few small areas where there are cracks to be patched in what is otherwise a record of outstanding designs and systems? Or do these problems provide us with evidence about deeper factors that we need to address if we are to maintain and improve aviation safety in a changing world? How do the reverberations of technology change on the flight deck provide insight into generic issues about developing human-centered technologies and systems (Winograd and Woods, 1997)? Based on a series of investigations of pilot interaction with cockpit automation (Sarter and Woods, 1992; 1994; 1995; 1997a, 1997 b), supplemented by surveys, operational experience and incident data from other studies (e.g., Degani et al., 1995; Eldredge et al., 1991; Tenney et al., 1995; Wiener, 1989), we too have found that the problems that surround crew interaction with automation are more than a series of individual glitches. These difficulties are symptoms that indicate deeper patterns and phenomena concerning human-machine cooperation and paths towards disaster. In addition, we find the same kinds of patterns behind results from studies of physician interaction with computer-based systems in critical care medicine (e.g., Moll van Charante et al., 1993; Obradovich and Woods, 1996; Cook and Woods, 1996). Many of the results and implications of this kind of research are synthesized and discussed in two comprehensive volumes, Billings (1996) and Woods et al. (1994). This paper summarizes the pattern that has emerged from our research, related research, incident reports, and accident investigations. It uses this new understanding of why problems arise to point to new investment strategies that can help us deal with the perceived "human error" problem, make automation more of a team player, and maintain and improve safety.

[Telemedicine today].

PubMed

Leis, A

2008-03-01

Modern communication and information technologies are ubiquitous nowadays, and the medical field is no exception. Telemedicine is a reasonable way to prevent accidents, communicate faster in an emergency, and improve medical care in the hospital. Home aftercare benefits from this development, too; the use of networks - started by the electronic health card - can help reduce costs. This article highlights these subjects and discusses national and international structures that promote the spread of health telematics. Barriers to this path are also shown.

JPRS Report, Science & Technology, Japan, 4th Intelligent Robots Symposium, Volume 2

DTIC Science & Technology

1989-03-16

accidents caused by strikes by robots,5 a quantitative model for safety evaluation,6 and evaluations of actual systems7 in order to contribute to...Mobile Robot Position Referencing Using Map-Based Vision Systems.... 160 Safety Evaluation of Man-Robot System 171 Fuzzy Path Pattern of Automatic...camera are made after the robot stops to prevent damage from occurring through obstacle interference. The position of the camera is indicated on the

Light-water-reactor safety research program. Quarterly progress report, July--September 1975

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1975-01-01

Progress is summarized in the following research and development areas: (1) loss-of-coolant accident research; heat transfer and fluid dynamics; (2) transient fuel response and fission-product release; and (3) mechanical properties of Zircaloy containing oxygen. Also included is an appendix on Kinetics of Fission Gas and Volatile Fission-product Behavior under Transient Conditions in LWR Fuel.

Relationships Among Tweets Related to Radiation: Visualization Using Co-Occurring Networks.

PubMed

Yagahara, Ayako; Hanai, Keiri; Hasegawa, Shin; Ogasawara, Katsuhiko

2018-03-15

After the Fukushima Daiichi nuclear accident on March 11, 2011, interest in, and fear of, radiation increased among citizens. When such accidents occur, appropriate risk communication must provided by the government. It is therefore necessary to understand the fears of citizens in the days after such accidents. This study aimed to identify the progression of people's concerns, specifically fear, from a study of radiation-related tweets in the days after the Fukushima Daiichi nuclear accident. From approximately 1.5 million tweets in Japanese including any of the phrases "radiation" (), "radioactivity" (), and "radioactive substance" () sent March 11-17, 2011, we extracted tweets that expressed fear. We then performed a morphological analysis on the extracted tweets. Citizens' fears were visualized by creating co-occurrence networks using co-occurrence degrees showing relationship strength. Moreover, we calculated the Jaccard coefficient, which is one of the co-occurrence indices for expressing the strength of the relationship between morphemes when creating networks. From the visualization of the co-occurrence networks, we found high citizen interest in "nuclear power plant" on March 11 and 12, "health" on March 12 and 13, "medium" on March 13 and 14, and "economy" on March 15. On March 16 and 17, citizens' interest changed to "lack of goods in the afflicted area." In each co-occurrence network, trending topics, citizens' fears, and opinions to the government were extracted. This study used Twitter to understand changes in the concerns of Japanese citizens during the week after the Fukushima Daiichi nuclear accident, with a focus specifically on citizens' fears. We found that immediately after the accident, the interest in the accident itself was high, and then interest shifted to concerns affecting life, such as health and economy, as the week progressed. Clarifying citizens' fears and the dissemination of information through mass media and social media can add to improved risk communication in the future. ©Ayako Yagahara, Keiri Hanai, Shin Hasegawa, Katsuhiko Ogasawara. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 15.03.2018.

Lessons Learned in Protection of the Public for the Accident at the Fukushima Daiichi Nuclear Power Plant.

PubMed

Callen, Jessica; Homma, Toshimitsu

2017-06-01

What insights can the accident at the Fukushima Daiichi nuclear power plant provide in the reality of decision making on actions to protect the public during a severe reactor and spent fuel pool emergency? In order to answer this question, and with the goal of limiting the consequences of any future emergencies at a nuclear power plant due to severe conditions, this paper presents the main actions taken in response to the emergency in the form of a timeline. The focus of this paper is those insights concerning the progression of an accident due to severe conditions at a light water reactor nuclear power plant that must be understood in order to protect the public.

Multi-phase model development to assess RCIC system capabilities under severe accident conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkland, Karen Vierow; Ross, Kyle; Beeny, Bradley

The Reactor Core Isolation Cooling (RCIC) System is a safety-related system that provides makeup water for core cooling of some Boiling Water Reactors (BWRs) with a Mark I containment. The RCIC System consists of a steam-driven Terry turbine that powers a centrifugal, multi-stage pump for providing water to the reactor pressure vessel. The Fukushima Dai-ichi accidents demonstrated that the RCIC System can play an important role under accident conditions in removing core decay heat. The unexpectedly sustained, good performance of the RCIC System in the Fukushima reactor demonstrates, firstly, that its capabilities are not well understood, and secondly, that themore » system has high potential for extended core cooling in accident scenarios. Better understanding and analysis tools would allow for more options to cope with a severe accident situation and to reduce the consequences. The objectives of this project were to develop physics-based models of the RCIC System, incorporate them into a multi-phase code and validate the models. This Final Technical Report details the progress throughout the project duration and the accomplishments.« less

Air oxidation of Zircaloy-4 in the 600-1000 °C temperature range: Modeling for ASTEC code application

NASA Astrophysics Data System (ADS)

Coindreau, O.; Duriez, C.; Ederli, S.

2010-10-01

Progress in the treatment of air oxidation of zirconium in severe accident (SA) codes are required for a reliable analysis of severe accidents involving air ingress. Air oxidation of zirconium can actually lead to accelerated core degradation and increased fission product release, especially for the highly-radiotoxic ruthenium. This paper presents a model to simulate air oxidation kinetics of Zircaloy-4 in the 600-1000 °C temperature range. It is based on available experimental data, including separate-effect experiments performed at IRSN and at Forschungszentrum Karlsruhe. The kinetic transition, named "breakaway", from a diffusion-controlled regime to an accelerated oxidation is taken into account in the modeling via a critical mass gain parameter. The progressive propagation of the locally initiated breakaway is modeled by a linear increase in oxidation rate with time. Finally, when breakaway propagation is completed, the oxidation rate stabilizes and the kinetics is modeled by a linear law. This new modeling is integrated in the severe accident code ASTEC, jointly developed by IRSN and GRS. Model predictions and experimental data from thermogravimetric results show good agreement for different air flow rates and for slow temperature transient conditions.

Multiple Damage Progression Paths in Model-Based Prognostics

NASA Technical Reports Server (NTRS)

Daigle, Matthew; Goebel, Kai Frank

2011-01-01

Model-based prognostics approaches employ domain knowledge about a system, its components, and how they fail through the use of physics-based models. Component wear is driven by several different degradation phenomena, each resulting in their own damage progression path, overlapping to contribute to the overall degradation of the component. We develop a model-based prognostics methodology using particle filters, in which the problem of characterizing multiple damage progression paths is cast as a joint state-parameter estimation problem. The estimate is represented as a probability distribution, allowing the prediction of end of life and remaining useful life within a probabilistic framework that supports uncertainty management. We also develop a novel variance control mechanism that maintains an uncertainty bound around the hidden parameters to limit the amount of estimation uncertainty and, consequently, reduce prediction uncertainty. We construct a detailed physics-based model of a centrifugal pump, to which we apply our model-based prognostics algorithms. We illustrate the operation of the prognostic solution with a number of simulation-based experiments and demonstrate the performance of the chosen approach when multiple damage mechanisms are active

Perceived Shrinkage of Motion Paths

ERIC Educational Resources Information Center

Sinico, Michele; Parovel, Giulia; Casco, Clara; Anstis, Stuart

2009-01-01

We show that human observers strongly underestimate a linear or circular trajectory that a luminous spot follows in the dark. At slow speeds, observers are relatively accurate, but, as the speed increases, the size of the path is progressively underestimated, by up to 35%. The underestimation imposes little memory load and does not require…

Social Cognitive Model of College Satisfaction: A Test of Measurement and Path Models

ERIC Educational Resources Information Center

Feldt, Ronald C.

2012-01-01

The study examined a model that integrates social-cognitive and trait-personality constructs to examine two domains of college satisfaction. Direct and indirect effects were observed for conscientiousness, perception of institutional resources, self-efficacy, and goal progress. Paths differed for personal and institutional satisfaction. Most…

Directors, Deans, Doctors, Divergers: The Four Career Paths of SSAOs

ERIC Educational Resources Information Center

Biddix, J. Patrick

2013-01-01

Career paths in student affairs generally follow a conventional course: graduate degree to entry-level position, progressive responsibility until middle management, and then a decision to remain, work to advance, or change fields. Studies on factors influencing career advancement have enlightened qualitative considerations individuals face when…

Techniques and Tools of NASA's Space Shuttle Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

McDanels, Steve J.

2005-01-01

The Space Shuttle Columbia accident investigation was a fusion of many disciplines into a single effort. From the recovery and reconstruction of the debris, Figure 1, to the analysis, both destructive and nondestructive, of chemical and metallurgical samples, Figure 2, a multitude of analytical techniques and tools were employed. Destructive and non-destructive testing were utilized in tandem to determine if a breach in the left wing of the Orbiter had occurred, and if so, the path of the resultant high temperature plasma flow. Nondestructive analysis included topometric scanning, laser mapping, and real-time radiography. These techniques were useful in constructing a three dimensional virtual representation of the reconstruction project, specifically the left wing leading edge reinforced carbon/carbon heat protectant panels. Similarly, they were beneficial in determining where sampling should be performed on the debris. Analytic testing included such techniques as Energy Dispersive Electron Microprobe Analysis (EMPA), Electron Spectroscopy Chemical Analysis (ESCA), and X-Ray dot mapping; these techniques related the characteristics of intermetallics deposited on the leading edge of the left wing adjacent to the location of a suspected plasma breach during reentry. The methods and results of the various analyses, along with their implications into the accident, are discussed, along with the findings and recommendations of the Columbia Accident Investigation Board. Likewise, NASA's Return To Flight efforts are highlighted.

United States Department of Energy severe accident research following the Fukushima Daiichi accidents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, M. T.; Corradini, M.; Rempe, J.

The U.S. Department of Energy (DOE) has played a major role in the U.S. response to the events at Fukushima Daiichi. During the first several weeks following the accident, U.S. assistance efforts were guided by results from a significant and diverse set of analyses. In the months that followed, a coordinated analysis activity aimed at gaining a more thorough understanding of the accident sequence was completed using laboratory-developed, system-level best-estimate accident analysis codes, while a parallel analysis was conducted by U.S. industry. A comparison of predictions for Unit 1 from these two studies indicated significant differences between MAAP and MELCORmore » results for key plant parameters, such as in-core hydrogen production. On that basis, a crosswalk was completed to determine the key modeling variations that led to these differences. In parallel with these activities, it became clear that there was a need to perform a technology gap evaluation on accident-tolerant components and severe accident analysis methodologies with the goal of identifying any data and/or knowledge gaps that may exist given the current state of light water reactor (LWR) severe accident research and augmented by insights from Fukushima. In addition, there is growing international recognition that data from Fukushima could significantly reduce uncertainties related to severe accident progression, particularly for boiling water reactors. On these bases, a group of U. S. experts in LWR safety and plant operations was convened by the DOE Office of Nuclear Energy (DOE-NE) to complete technology gap analysis and Fukushima forensics data needs identification activities. The results from these activities were used as the basis for refining DOE-NE's severe accident research and development (R&D) plan. Finally, this paper provides a high-level review of DOE-sponsored R&D efforts in these areas, including planned activities on accident-tolerant components and accident analysis methods.« less

United States Department of Energy severe accident research following the Fukushima Daiichi accidents

DOE PAGES

Farmer, M. T.; Corradini, M.; Rempe, J.; ...

2016-11-02

The U.S. Department of Energy (DOE) has played a major role in the U.S. response to the events at Fukushima Daiichi. During the first several weeks following the accident, U.S. assistance efforts were guided by results from a significant and diverse set of analyses. In the months that followed, a coordinated analysis activity aimed at gaining a more thorough understanding of the accident sequence was completed using laboratory-developed, system-level best-estimate accident analysis codes, while a parallel analysis was conducted by U.S. industry. A comparison of predictions for Unit 1 from these two studies indicated significant differences between MAAP and MELCORmore » results for key plant parameters, such as in-core hydrogen production. On that basis, a crosswalk was completed to determine the key modeling variations that led to these differences. In parallel with these activities, it became clear that there was a need to perform a technology gap evaluation on accident-tolerant components and severe accident analysis methodologies with the goal of identifying any data and/or knowledge gaps that may exist given the current state of light water reactor (LWR) severe accident research and augmented by insights from Fukushima. In addition, there is growing international recognition that data from Fukushima could significantly reduce uncertainties related to severe accident progression, particularly for boiling water reactors. On these bases, a group of U. S. experts in LWR safety and plant operations was convened by the DOE Office of Nuclear Energy (DOE-NE) to complete technology gap analysis and Fukushima forensics data needs identification activities. The results from these activities were used as the basis for refining DOE-NE's severe accident research and development (R&D) plan. Finally, this paper provides a high-level review of DOE-sponsored R&D efforts in these areas, including planned activities on accident-tolerant components and accident analysis methods.« less

System and Method for Aiding Pilot Preview, Rehearsal, Review, and Real-Time Visual Acquisition of Flight Mission Progress

NASA Technical Reports Server (NTRS)

Prinzel, III, Lawrence J. (Inventor); Pope, Alan T. (Inventor); Williams, Steven P. (Inventor); Bailey, Randall E. (Inventor); Arthur, Jarvis J. (Inventor); Kramer, Lynda J. (Inventor); Schutte, Paul C. (Inventor)

2012-01-01

Embodiments of the invention permit flight paths (current and planned) to be viewed from various orientations to provide improved path and terrain awareness via graphical two-dimensional or three-dimensional perspective display formats. By coupling the flight path information with a terrain database, uncompromising terrain awareness relative to the path and ownship is provided. In addition, missed approaches, path deviations, and any navigational path can be reviewed and rehearsed before performing the actual task. By rehearsing a particular mission, check list items can be reviewed, terrain awareness can be highlighted, and missed approach procedures can be discussed by the flight crew. Further, the use of Controller Pilot Datalink Communications enables data-linked path, flight plan changes, and Air Traffic Control requests to be integrated into the flight display of the present invention.

Nationwide Survey of Local Emergency Planning Committees

EPA Pesticide Factsheets

These 2008 and 1999 surveys track the progress of LEPCs by assessing their current activity; and probe current practices and preferences regarding issues such as communication, accident prevention, and Office of Emergency Management products and services.

Millimeter-wave studies

NASA Technical Reports Server (NTRS)

Allen, Kenneth C.

1988-01-01

Progress on millimeter-wave propagation experiments in Hawaii is reported. A short path for measuring attenuation in rain at 9.6, 28.8, 57.6, and 96.1 GHz is in operation. A slant path from Hilo to the top of Mauna Kea is scheduled. On this path, scattering from rain and clouds that may cause interference for satellites closely spaced in geosynchronous orbit will be measured at the same frequencies at 28.8 and 96.1 GHz. In addition the full transmission matrix will be measured at the same frequencies on the slant path. The technique and equipment used to measure the transmission matrix are described.

The Altimetric Wet Tropospheric Correction: Progress Since The ERS-1 Mission

NASA Astrophysics Data System (ADS)

Eymard, L.; Obligis, E.

2006-07-01

To correct for the path delay due to humidity in the troposphere, dedicated microwave radiometers have been added to altimeters on ESA and NASA/CNES missions. This paper presents the major issues with calibration and retrieval of the wet tropospheric path d elay s ince E RS1, a s w ell a s n ew developments for in-flight monitoring, retrieval of the path delay over the open ocean and in coastal regions.

Clear lens extraction for the treatment of persistent accommodative spasm after head trauma.

PubMed

McMurray, Catherine J; Burley, Celeste D; Elder, Mark J

2004-12-01

We report the case of a 28-year-old man with decreased visual acuity after closed head trauma sustained in a motor vehicle accident 16 weeks earlier. Several structures thought to be associated with the control of accommodation were injured. The patient had a persistent accommodative spasm causing up to 7.0 diopters of pseudomyopia. We present the patient's progress through the clinic, including manifest and cycloplegic refractions and results of a trial with atropine drops, and successful transition to bilateral pseudophakia 2 years and 9 months after the accident.

Providing Career Guidance to Adolescents through Digital Games: A Case Study

ERIC Educational Resources Information Center

Dunwell, Ian; Lameras, Petros; de Freitas, Sara; Petridis, Panos; Hendrix, Maurice; Arnab, Sylvester; Star, Kam

2014-01-01

In an evolving global workplace, it is increasingly important for graduates and school-leavers to possess an understanding of the job market, their relevant skills, and career progression paths. However, both the marketplace and career paths are becoming increasingly dynamic, with employees more frequently moving between sectors and positions than…

GEOSTAR-II: A Prototype Water Vapor Imager/Sounder for the Path Mission

NASA Technical Reports Server (NTRS)

Gaier, Todd; Lambrigtsen, Bjorn; Kangaslahti, Pekka; Lim, Boon; Tanner, Alan; Harding, Dennis; Owen, Heather; Soria, Mary; ODwyer, Ian; Ruf, Christopher;

Stochastic Cell Fate Progression in Embryonic Stem Cells

NASA Astrophysics Data System (ADS)

Zou, Ling-Nan; Doyle, Adele; Jang, Sumin; Ramanathan, Sharad

2013-03-01

Studies on the directed differentiation of embryonic stem (ES) cells suggest that some early developmental decisions may be stochastic in nature. To identify the sources of this stochasticity, we analyzed the heterogeneous expression of key transcription factors in single ES cells as they adopt distinct germ layer fates. We find that under sufficiently stringent signaling conditions, the choice of lineage is unambiguous. ES cells flow into differentiated fates via diverging paths, defined by sequences of transitional states that exhibit characteristic co-expression of multiple transcription factors. These transitional states have distinct responses to morphogenic stimuli; by sequential exposure to multiple signaling conditions, ES cells are steered towards specific fates. However, the rate at which cells travel down a developmental path is stochastic: cells exposed to the same signaling condition for the same amount of time can populate different states along the same path. The heterogeneity of cell states seen in our experiments therefore does not reflect the stochastic selection of germ layer fates, but the stochastic rate of progression along a chosen developmental path. Supported in part by the Jane Coffin Childs Fund

Study of the application of ERTS-A imagery to fracture-related mine safety hazards in the coal mining industry

NASA Technical Reports Server (NTRS)

Wier, C. E.; Wobber, F. J. (Principal Investigator); Russell, O. R.; Amato, R. V.

1972-01-01

The author has identified the following significant results. Various data compilation and analysis activities in support of ERTS-1 imagery interpretation are in progress or are completed. These include the compilation of mine accident data, areas of mine roof instability and the analysis of high altitude color infrared photography and low altitude color and color infrared photography which was acquired by NASA in support of the project. The photography reveals that many fracture lineaments are detectable through a varied thickness of glacial till. These data will be compiled on a series of 1:250,000 scale base maps and evaluated for a correlation between fracture zones and mine accidents and rooffalls. Due to high occurrence of cloud cover in the project area and to the delay in imagery shipments, little progress has been made in the analysis of ERTS-1 imagery.

Dynamics Modeling and Simulation of Large Transport Airplanes in Upset Conditions

NASA Technical Reports Server (NTRS)

Foster, John V.; Cunningham, Kevin; Fremaux, Charles M.; Shah, Gautam H.; Stewart, Eric C.; Rivers, Robert A.; Wilborn, James E.; Gato, William

2005-01-01

As part of NASA's Aviation Safety and Security Program, research has been in progress to develop aerodynamic modeling methods for simulations that accurately predict the flight dynamics characteristics of large transport airplanes in upset conditions. The motivation for this research stems from the recognition that simulation is a vital tool for addressing loss-of-control accidents, including applications to pilot training, accident reconstruction, and advanced control system analysis. The ultimate goal of this effort is to contribute to the reduction of the fatal accident rate due to loss-of-control. Research activities have involved accident analyses, wind tunnel testing, and piloted simulation. Results have shown that significant improvements in simulation fidelity for upset conditions, compared to current training simulations, can be achieved using state-of-the-art wind tunnel testing and aerodynamic modeling methods. This paper provides a summary of research completed to date and includes discussion on key technical results, lessons learned, and future research needs.

Analysis of Alerting System Failures in Commercial Aviation Accidents

NASA Technical Reports Server (NTRS)

Mumaw, Randall J.

2017-01-01

The role of an alerting system is to make the system operator (e.g., pilot) aware of an impending hazard or unsafe state so the hazard can be avoided or managed successfully. A review of 46 commercial aviation accidents (between 1998 and 2014) revealed that, in the vast majority of events, either the hazard was not alerted or relevant hazard alerting occurred but failed to aid the flight crew sufficiently. For this set of events, alerting system failures were placed in one of five phases: Detection, Understanding, Action Selection, Prioritization, and Execution. This study also reviewed the evolution of alerting system schemes in commercial aviation, which revealed naive assumptions about pilot reliability in monitoring flight path parameters; specifically, pilot monitoring was assumed to be more effective than it actually is. Examples are provided of the types of alerting system failures that have occurred, and recommendations are provided for alerting system improvements.

Quantitative modelling in cognitive ergonomics: predicting signals passed at danger.

PubMed

Moray, Neville; Groeger, John; Stanton, Neville

2017-02-01

This paper shows how to combine field observations, experimental data and mathematical modelling to produce quantitative explanations and predictions of complex events in human-machine interaction. As an example, we consider a major railway accident. In 1999, a commuter train passed a red signal near Ladbroke Grove, UK, into the path of an express. We use the Public Inquiry Report, 'black box' data, and accident and engineering reports to construct a case history of the accident. We show how to combine field data with mathematical modelling to estimate the probability that the driver observed and identified the state of the signals, and checked their status. Our methodology can explain the SPAD ('Signal Passed At Danger'), generate recommendations about signal design and placement and provide quantitative guidance for the design of safer railway systems' speed limits and the location of signals. Practitioner Summary: Detailed ergonomic analysis of railway signals and rail infrastructure reveals problems of signal identification at this location. A record of driver eye movements measures attention, from which a quantitative model for out signal placement and permitted speeds can be derived. The paper is an example of how to combine field data, basic research and mathematical modelling to solve ergonomic design problems.

Light Water Reactor Sustainability Program, U.S. Efforts in Support of Examinations at Fukushima Daiichi-2017 Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, Mitchell T.

Although the accident signatures from each unit at the Fukushima Daiichi Nuclear Power Station (NPS) [Daiichi] differ, much is not known about the end-state of core materials within these units. Some of this uncertainty can be attributed to a lack of information related to cooling system operation and cooling water injection. There is also uncertainty in our understanding of phenomena affecting: a) in-vessel core damage progression during severe accidents in boiling water reactors (BWRs), and b) accident progression after vessel failure (ex-vessel progression) for BWRs and Pressurized Water Reactors (PWRs). These uncertainties arise due to limited full scale prototypic data.more » Similar to what occurred after the accident at Three Mile Island Unit 2, these Daiichi units offer the international community a means to reduce such uncertainties by obtaining prototypic data from multiple full-scale BWR severe accidents. Information obtained from Daiichi is required to inform Decontamination and Decommissioning activities, improving the ability of the Tokyo Electric Power Company Holdings, Incorporated (TEPCO Holdings) to characterize potential hazards and to ensure the safety of workers involved with cleanup activities. This document, which has been updated to include FY2017 information, summarizes results from U.S. efforts to use information obtained by TEPCO Holdings to enhance the safety of existing and future nuclear power plant designs. This effort, which was initiated in 2014 by the Reactor Safety Technologies Pathway of the Department of Energy Office of Nuclear Energy Light Water Reactor (LWR) Sustainability Program, consists of a group of U.S. experts in LWR safety and plant operations that have identified examination needs and are evaluating TEPCO Holdings information from Daiichi that address these needs. Each year, annual reports include examples demonstrating that significant safety insights are being obtained in the areas of component performance, fission product release and transport, debris end-state location, and combustible gas generation and transport. In addition to reducing uncertainties related to severe accident modeling progression, these insights are being used to update guidance for severe accident prevention, mitigation, and emergency planning. Furthermore, reduced uncertainties in modeling the events at Daiichi will improve the realism of reactor safety evaluations and inform future D&D activities by improving the capability for characterizing potential hazards to workers involved with cleanup activities. Highlights in this FY2017 report include new insights with respect to the forces required to produce the observed Daiichi Unit 1 (1F1) shield plug endstate, the observed leakage from 1F1 components, and the amount of combustible gas generation required to produce the observed explosions in Daiichi Units 3 and 4 (1F3 and 1F4). This report contains an appendix with a list of examination needs that was updated after U.S. experts reviewed recently obtained information from examinations at Daiichi. Additional details for higher priority, near-term, examination activities are also provided. This report also includes an appendix with a description of an updated website that has been reformatted to better assist U.S. experts by providing information in an archived retrievable location, as well as an appendix summarizing U.S. Forensics activities to host the TMI-2 Knowledge Transfer and Relevance to Fukushima Meeting that was held in Idaho Falls, ID, on October 10-14, 2016.« less

Lessons from Fukushima for Improving the Safety of Nuclear Reactors

NASA Astrophysics Data System (ADS)

Lyman, Edwin

2012-02-01

The March 2011 accident at the Fukushima Daiichi nuclear power plant has revealed serious vulnerabilities in the design, operation and regulation of nuclear power plants. While some aspects of the accident were plant- and site-specific, others have implications that are broadly applicable to the current generation of nuclear plants in operation around the world. Although many of the details of the accident progression and public health consequences are still unclear, there are a number of lessons that can already be drawn. The accident demonstrated the need at nuclear plants for robust, highly reliable backup power sources capable of functioning for many days in the event of a complete loss of primary off-site and on-site electrical power. It highlighted the importance of detailed planning for severe accident management that realistically evaluates the capabilities of personnel to carry out mitigation operations under extremely hazardous conditions. It showed how emergency plans rooted in the assumption that only one reactor at a multi-unit site would be likely to experience a crisis fail miserably in the event of an accident affecting multiple reactor units simultaneously. It revealed that alternate water injection following a severe accident could be needed for weeks or months, generating large volumes of contaminated water that must be contained. And it reinforced the grim lesson of Chernobyl: that a nuclear reactor accident could lead to widespread radioactive contamination with profound implications for public health, the economy and the environment. While many nations have re-examined their policies regarding nuclear power safety in the months following the accident, it remains to be seen to what extent the world will take the lessons of Fukushima seriously and make meaningful changes in time to avert another, and potentially even worse, nuclear catastrophe.

Drug Violations and Aviation Accidents: Findings from the U.S. Mandatory Drug Testing Programs

PubMed Central

Li, Guohua; Baker, Susan P.; Zhao, Qi; Brady, Joanne E.; Lang, Barbara H.; Rebok, George W.; DiMaggio, Charles

2012-01-01

Aims To assess the role of drug violations in aviation accidents. Design Case-control analysis. Setting Commercial aviation in the United States. Participants Aviation employees who were tested for drugs during 1995 through 2005 under the post-accident testing program (cases, n=4,977) or under the random testing program (controls, n=1,129,922). Measurements Point prevalence of drug violations, odds ratio of accident involvement, and attributable risk in the population. A drug violation was defined as a confirmed positive test for marijuana (≥ 50 ng/ml), cocaine (≥ 300 ng/ml), amphetamines (≥1000 ng/ml), opiates (≥ 2000 ng/ml), or phencyclidine (≥ 25 ng/ml). Findings The prevalence of drug violations was 0.64% [95% confidence interval (CI), 0.62–0.65%] in random drug tests and 1.82% (95% CI, 1.47–2.24%) in post-accident tests. The odds of accident involvement for employees who tested positive for drugs was almost three times the odds for those who tested negative (odds ratio 2.90, 95% CI, 2.35–3.57), with an estimated attributable risk of 1.2%. Marijuana accounted for 67.3% of the illicit drugs detected. The proportion of illicit drugs represented by amphetamines increased progressively during the study period, from 3.4% in 1995 to 10.3% in 2005 (p<0.0001). Conclusions Use of illicit drugs by aviation employees is associated with a significantly increased risk of accident involvement. Due to the very low prevalence, drug violations contribute to only a small fraction of aviation accidents. PMID:21306594

Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades

PubMed Central

Li, Karl; Laird, Angela R.; Price, Larry R.; McKay, D. Reese; Blangero, John; Glahn, David C.; Fox, Peter T.

2016-01-01

The default mode network (DMN) is a set of regions that is tonically engaged during the resting state and exhibits task-related deactivation that is readily reproducible across a wide range of paradigms and modalities. The DMN has been implicated in numerous disorders of cognition and, in particular, in disorders exhibiting age-related cognitive decline. Despite these observations, investigations of the DMN in normal aging are scant. Here, we used blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) acquired during rest to investigate age-related changes in functional connectivity of the DMN in 120 healthy normal volunteers comprising six, 20-subject, decade cohorts (from 20–29 to 70–79). Structural equation modeling (SEM) was used to assess age-related changes in inter-regional connectivity within the DMN. SEM was applied both using a previously published, meta-analytically derived, node-and-edge model, and using exploratory modeling searching for connections that optimized model fit improvement. Although the two models were highly similar (only 3 of 13 paths differed), the sample demonstrated significantly better fit with the exploratory model. For this reason, the exploratory model was used to assess age-related changes across the decade cohorts. Progressive, highly significant changes in path weights were found in 8 (of 13) paths: four rising, and four falling (most changes were significant by the third or fourth decade). In all cases, rising paths and falling paths projected in pairs onto the same nodes, suggesting compensatory increases associated with age-related decreases. This study demonstrates that age-related changes in DMN physiology (inter-regional connectivity) are bidirectional, progressive, of early onset and part of normal aging. PMID:27378909

Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades.

PubMed

Li, Karl; Laird, Angela R; Price, Larry R; McKay, D Reese; Blangero, John; Glahn, David C; Fox, Peter T

2016-01-01

The default mode network (DMN) is a set of regions that is tonically engaged during the resting state and exhibits task-related deactivation that is readily reproducible across a wide range of paradigms and modalities. The DMN has been implicated in numerous disorders of cognition and, in particular, in disorders exhibiting age-related cognitive decline. Despite these observations, investigations of the DMN in normal aging are scant. Here, we used blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) acquired during rest to investigate age-related changes in functional connectivity of the DMN in 120 healthy normal volunteers comprising six, 20-subject, decade cohorts (from 20-29 to 70-79). Structural equation modeling (SEM) was used to assess age-related changes in inter-regional connectivity within the DMN. SEM was applied both using a previously published, meta-analytically derived, node-and-edge model, and using exploratory modeling searching for connections that optimized model fit improvement. Although the two models were highly similar (only 3 of 13 paths differed), the sample demonstrated significantly better fit with the exploratory model. For this reason, the exploratory model was used to assess age-related changes across the decade cohorts. Progressive, highly significant changes in path weights were found in 8 (of 13) paths: four rising, and four falling (most changes were significant by the third or fourth decade). In all cases, rising paths and falling paths projected in pairs onto the same nodes, suggesting compensatory increases associated with age-related decreases. This study demonstrates that age-related changes in DMN physiology (inter-regional connectivity) are bidirectional, progressive, of early onset and part of normal aging.

A path analysis model for explaining unsafe behavior in workplaces: the effect of perceived work pressure.

PubMed

Ghasemi, Fakhradin; Kalatpour, Omid; Moghimbeigi, Abbas; Mohhamadfam, Iraj

2018-06-01

Unsafe behavior is closely related to occupational accidents. Work pressure is one the main factors affecting employees' behavior. The aim of the present study was to provide a path analysis model for explaining how work pressure affects safety behavior. Using a self-administered questionnaire, six variables supposed to affect safety employees' behavior were measured. The path analysis model was constructed based on several hypotheses. The goodness of fit of the model was assessed using both absolute and comparative fit indices. Work pressure was determined not to influence safety behavior directly. However, it negatively influenced other variables. Group attitude and personal attitude toward safety were the main factors mediating the effect of work pressure on safety behavior. Among the variables investigated in the present study, group attitude, personal attitude and work pressure had the strongest effects on safety behavior. Managers should consider that in order to improve employees' safety behavior, work pressure should be reduced to a reasonable level, and concurrently a supportive environment, which ensures a positive group attitude toward safety, should be provided. Replication of the study is recommended.

Grid Visualization Tool

NASA Technical Reports Server (NTRS)

Chouinard, Caroline; Fisher, Forest; Estlin, Tara; Gaines, Daniel; Schaffer, Steven

2005-01-01

The Grid Visualization Tool (GVT) is a computer program for displaying the path of a mobile robotic explorer (rover) on a terrain map. The GVT reads a map-data file in either portable graymap (PGM) or portable pixmap (PPM) format, representing a gray-scale or color map image, respectively. The GVT also accepts input from path-planning and activity-planning software. From these inputs, the GVT generates a map overlaid with one or more rover path(s), waypoints, locations of targets to be explored, and/or target-status information (indicating success or failure in exploring each target). The display can also indicate different types of paths or path segments, such as the path actually traveled versus a planned path or the path traveled to the present position versus planned future movement along a path. The program provides for updating of the display in real time to facilitate visualization of progress. The size of the display and the map scale can be changed as desired by the user. The GVT was written in the C++ language using the Open Graphics Library (OpenGL) software. It has been compiled for both Sun Solaris and Linux operating systems.

A comparative study of road traffic accidents in West Malaysia.

PubMed Central

Silva, J. F.

1978-01-01

The problem of road traffic accidents in developing countries is now becoming a cause for concern. This is more so as preventive measures have not kept pace with economic progress and development. This paper reviews the present situation in West Malaysia, one of the better developed countries of the East, during the period 1970 to 1975. A comparative study has been made between the United States and Malaysia. To enable the urgency of the problem in developing countries to be appreciated the increases in the country's population and in the number of vehicles in use and their relation to the lesser increase in road mileage over the period of study have been discussed. The study has considered every aspect of the causative factors leading to traffic accidents, such as the effects of weather, seasonal variation, and road and lighting conditions. The common human errors leading to accidents have been discussed. Other factors, such as the ethnic distribution in Malaysia, and their relation to road accidents have shown the effect of the social structure on the problems. The data evaluated in this study make it clear that preventive measures are very necessary in underdeveloped as well as in developed countries. PMID:718073

A comparative study of road traffic accidents in West Malaysia.

PubMed

Silva, J F

1978-11-01

The problem of road traffic accidents in developing countries is now becoming a cause for concern. This is more so as preventive measures have not kept pace with economic progress and development. This paper reviews the present situation in West Malaysia, one of the better developed countries of the East, during the period 1970 to 1975. A comparative study has been made between the United States and Malaysia. To enable the urgency of the problem in developing countries to be appreciated the increases in the country's population and in the number of vehicles in use and their relation to the lesser increase in road mileage over the period of study have been discussed. The study has considered every aspect of the causative factors leading to traffic accidents, such as the effects of weather, seasonal variation, and road and lighting conditions. The common human errors leading to accidents have been discussed. Other factors, such as the ethnic distribution in Malaysia, and their relation to road accidents have shown the effect of the social structure on the problems. The data evaluated in this study make it clear that preventive measures are very necessary in underdeveloped as well as in developed countries.

Aspects Concerning The Rules And The Investigation Of Traffic Accidents As Work Accidents

NASA Astrophysics Data System (ADS)

Tarnu, Lucian Ioan

2015-07-01

When Romania joined the European Union, it was imposed that the Romanian legislation in the field of the security and health at work be in line with the European one. The concept of health as it is defined by the International Body of Health, refers to a good physical, mental and social condition. The improvement of the activity of preventing the traffic accidents as work accidents must have as basis the correct and accurate evaluation of risks of getting injured. The goal of the activity of prevention and protection is to ensure the best working conditions, the prevention of accidents and occupational diseases and the adjustment to the scientific and technological progress. In the road transport sector, as in any other sector, it is very important to pay attention to working conditions to ensure a workforce motivated and well qualified. Some features make it a more difficult sector risk management than other sectors. However, if one takes into account how it works in practice this sector and the characteristics of drivers and how they work routinely, risks, dangers and threats can be managed efficiently and with great success.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez, Salvador B.

SNL has a combination of experimental facilities, nuclear engineering, nuclear security, severe nuclear accidents, and nuclear safeguards expertise that can enable significant progress towards molten salts and fuels for Molten Salt Reactors (MSRs). The following areas and opportunities are discussed in more detail in this white paper.

Traffic accidents involving fatigue driving and their extent of casualties.

PubMed

Zhang, Guangnan; Yau, Kelvin K W; Zhang, Xun; Li, Yanyan

2016-02-01

The rapid progress of motorization has increased the number of traffic-related casualties. Although fatigue driving is a major cause of traffic accidents, the public remains not rather aware of its potential harmfulness. Fatigue driving has been termed as a "silent killer." Thus, a thorough study of traffic accidents and the risk factors associated with fatigue-related casualties is of utmost importance. In this study, we analyze traffic accident data for the period 2006-2010 in Guangdong Province, China. The study data were extracted from the traffic accident database of China's Public Security Department. A logistic regression model is used to assess the effect of driver characteristics, type of vehicles, road conditions, and environmental factors on fatigue-related traffic accident occurrence and severity. On the one hand, male drivers, trucks, driving during midnight to dawn, and morning rush hours are identified as risk factors of fatigue-related crashes but do not necessarily result in severe casualties. Driving at night without street-lights contributes to fatigue-related crashes and severe casualties. On the other hand, while factors such as less experienced drivers, unsafe vehicle status, slippery roads, driving at night with street-lights, and weekends do not have significant effect on fatigue-related crashes, yet accidents associated with these factors are likely to have severe casualties. The empirical results of the present study have important policy implications on the reduction of fatigue-related crashes as well as their severity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Remediation to restoration to revitalization: A path forward for AOCs progress report

EPA Science Inventory

At the 2016 Great Lakes Areas of Concern (AOC) Conference, researchers from the USEPA Office of Research and Development (ORD) sparked conversation about community revitalization and the different states of progress throughout the basin. The conversation was meant to provide AOC ...

Short communication: Genetic lag represents commercial herd genetic merit more accurately than the 4-path selection model.

PubMed

Dechow, C D; Rogers, G W

2018-05-01

Expectation of genetic merit in commercial dairy herds is routinely estimated using a 4-path genetic selection model that was derived for a closed population, but commercial herds using artificial insemination sires are not closed. The 4-path model also predicts a higher rate of genetic progress in elite herds that provide artificial insemination sires than in commercial herds that use such sires, which counters other theoretical assumptions and observations of realized genetic responses. The aim of this work is to clarify whether genetic merit in commercial herds is more accurately reflected under the assumptions of the 4-path genetic response formula or by a genetic lag formula. We demonstrate by tracing the transmission of genetic merit from parents to offspring that the rate of genetic progress in commercial dairy farms is expected to be the same as that in the genetic nucleus. The lag in genetic merit between the nucleus and commercial farms is a function of sire and dam generation interval, the rate of genetic progress in elite artificial insemination herds, and genetic merit of sires and dams. To predict how strategies such as the use of young versus daughter-proven sires, culling heifers following genomic testing, or selective use of sexed semen will alter genetic merit in commercial herds, genetic merit expectations for commercial herds should be modeled using genetic lag expectations. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

The Effect of Delamination on Damage Path and Failure Load Prediction for Notched Composite Laminates

NASA Technical Reports Server (NTRS)

Satyanarayana, Arunkumar; Bogert, Philip B.; Chunchu, Prasad B.

2007-01-01

The influence of delamination on the progressing damage path and initial failure load in composite laminates is investigated. Results are presented from a numerical and an experimental study of center-notched tensile-loaded coupons. The numerical study includes two approaches. The first approach considers only intralaminar (fiber breakage and matrix cracking) damage modes in calculating the progression of the damage path. In the second approach, the model is extended to consider the effect of interlaminar (delamination) damage modes in addition to the intralaminar damage modes. The intralaminar damage is modeled using progressive damage analysis (PDA) methodology implemented with the VUMAT subroutine in the ABAQUS finite element code. The interlaminar damage mode has been simulated using cohesive elements in ABAQUS. In the experimental study, 2-3 specimens each of two different stacking sequences of center-notched laminates are tensile loaded. The numerical results from the two different modeling approaches are compared with each other and the experimentally observed results for both laminate types. The comparisons reveal that the second modeling approach, where the delamination damage mode is included together with the intralaminar damage modes, better simulates the experimentally observed damage modes and damage paths, which were characterized by splitting failures perpendicular to the notch tips in one or more layers. Additionally, the inclusion of the delamination mode resulted in a better prediction of the loads at which the failure took place, which were higher than those predicted by the first modeling approach which did not include delaminations.

Measuring Progress in Chemical Safety: A Guide for Local Emergency Planning Committees and Similar Groups

EPA Pesticide Factsheets

LEPCs set goals and determine if their actions continue to achieve desired outcomes. Based on Guidance on Developing Safety Performance Indicators related to Chemical Accident Prevention, Preparedness and Response for Public Authorities and Communities.

Medical and psychological aspects of mass air transportation.

DOT National Transportation Integrated Search

1971-03-01

The increase in air transportation depends not only on the technological progress and the availability of more and larger aircraft, but also on the corresponding increase in flight safety. Since, in most of the aircraft accidents, pilot error is a co...

A Stochastic Sprint in the Vague Direction of Data Science: Perspectives from a Graduate Student and Aspiring Data Scientist.

NASA Astrophysics Data System (ADS)

Barberie, S. R.

2015-12-01

Since data science does not exist as a stand-alone discipline within major universities, learning data science, or even learning that data science exists is, for an aspiring researcher at the graduate or undergraduate level, something that only happens by accident. Here I present my own series of accidents that transformed me from a somewhat aimless graduate student into an aspiring data scientist and the challenges that that aspiration has created in fitting into traditional academic programs and finding a coherent path forward. I also present my current conundrum: with the clear intention of pursuing data science but an academic background in other subjects, where do I go from here? Do I start my education over, pursue professional certification courses and bootcamp programs, or engage in not-very-marketable self study? This career chasm creates a strange environment for aspiring data scientists where we have a destination, but not a clear road to get there. I also discuss how joining a data focused interest group called The Federation of Earth Science Information Partners (ESIP) bridged some of the gap left by Academia in allowing me to network and collaborate with real data scientists from a variety of backgrounds. Organizations like this may someday play an important role in helping aspiring data scientists find their place, although for the moment many gaps and obstacles still remain, and the path forward is far from clear.

Conceptual Soundness, Metric Development, Benchmarking, and Targeting for PATH Subprogram Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mosey. G.; Doris, E.; Coggeshall, C.

The objective of this study is to evaluate the conceptual soundness of the U.S. Department of Housing and Urban Development (HUD) Partnership for Advancing Technology in Housing (PATH) program's revised goals and establish and apply a framework to identify and recommend metrics that are the most useful for measuring PATH's progress. This report provides an evaluative review of PATH's revised goals, outlines a structured method for identifying and selecting metrics, proposes metrics and benchmarks for a sampling of individual PATH programs, and discusses other metrics that potentially could be developed that may add value to the evaluation process. The frameworkmore » and individual program metrics can be used for ongoing management improvement efforts and to inform broader program-level metrics for government reporting requirements.« less

Intelligent path loss prediction engine design using machine learning in the urban outdoor environment

NASA Astrophysics Data System (ADS)

Wang, Ruichen; Lu, Jingyang; Xu, Yiran; Shen, Dan; Chen, Genshe; Pham, Khanh; Blasch, Erik

2018-05-01

Due to the progressive expansion of public mobile networks and the dramatic growth of the number of wireless users in recent years, researchers are motivated to study the radio propagation in urban environments and develop reliable and fast path loss prediction models. During last decades, different types of propagation models are developed for urban scenario path loss predictions such as the Hata model and the COST 231 model. In this paper, the path loss prediction model is thoroughly investigated using machine learning approaches. Different non-linear feature selection methods are deployed and investigated to reduce the computational complexity. The simulation results are provided to demonstratethe validity of the machine learning based path loss prediction engine, which can correctly determine the signal propagation in a wireless urban setting.

Influence of Shear Stiffness Degradation on Crack Paths in Uni-Directional Composite Laminates

NASA Technical Reports Server (NTRS)

Satyanarayana, Arunkumar; Bogert, Phil B.

2017-01-01

Influence of shear stiffness degradation in an element, due to damage, on crack paths in uni-directional laminates has been demonstrated. A new shear stiffness degradation approach to improve crack path prediction has been developed and implemented in an ABAQUS/Explicit frame work using VUMAT. Three progressive failure analysis models, built-in ABAQUS (TradeMark), original COmplete STress Reduction (COSTR) and the modified COSTR damage models have been utilized in this study to simulate crack paths in five unidirectional notched laminates, 15deg, 30deg, 45deg, 60deg and 75deg under uniaxial tension load. Results such as crack paths and load vs. edge displacement curves are documented in this report. Modified COSTR damage model shows better accuracy in predicting crack paths in all the uni-directional laminates compared to the ABAQUS (TradeMark) and the original COSTR damage models.

Behavior Modification with an Aphasic Man

ERIC Educational Resources Information Center

Ince, Laurence P.

1973-01-01

Techniques based upon operant conditioning were employed with a male patient who had sustained a cerebrovascular accident with consequent right hemiplegia and expressive asphasia. A combination of positive verbal reinforcement and feedback of progress were utilized to improve language fluency and speed of typing. (Author)

Self-controlled learning benefits: exploring contributions of self-efficacy and intrinsic motivation via path analysis.

PubMed

Ste-Marie, Diane M; Carter, Michael J; Law, Barbi; Vertes, Kelly; Smith, Victoria

2016-09-01

Research has shown learning advantages for self-controlled practice contexts relative to yoked (i.e., experimenter-imposed) contexts; yet, explanations for this phenomenon remain relatively untested. We examined, via path analysis, whether self-efficacy and intrinsic motivation are important constructs for explaining self-controlled learning benefits. The path model was created using theory-based and empirically supported relationships to examine causal links between these psychological constructs and physical performance. We hypothesised that self-efficacy and intrinsic motivation would have greater predictive power for learning under self-controlled compared to yoked conditions. Participants learned double-mini trampoline progressions, and measures of physical performance, self-efficacy and intrinsic motivation were collected over two practice days and a delayed retention day. The self-controlled group (M = 2.04, SD = .98) completed significantly more skill progressions in retention than their yoked counterparts (M = 1.3, SD = .65). The path model displayed adequate fit, and similar significant path coefficients were found for both groups wherein each variable was predominantly predicted by its preceding time point (e.g., self-efficacy time 1 predicts self-efficacy time 2). Interestingly, the model was not moderated by group; thus, failing to support the hypothesis that self-efficacy and intrinsic motivation have greater predictive power for learning under self-controlled relative to yoked conditions.

Expedition 8 Crew Interviews: C. Michael Foale - CDR

NASA Technical Reports Server (NTRS)

2003-01-01

C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

BNL program in support of LWR degraded-core accident analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginsberg, T.; Greene, G.A.

1982-01-01

Two major sources of loading on dry watr reactor containments are steam generatin from core debris water thermal interactions and molten core-concrete interactions. Experiments are in progress at BNL in support of analytical model development related to aspects of the above containment loading mechanisms. The work supports development and evaluation of the CORCON (Muir, 1981) and MARCH (Wooton, 1980) computer codes. Progress in the two programs is described in this paper. 8 figures.

Comparison of Damage Path Predictions for Composite Laminates by Explicit and Standard Finite Element Analysis Tools

NASA Technical Reports Server (NTRS)

Bogert, Philip B.; Satyanarayana, Arunkumar; Chunchu, Prasad B.

2006-01-01

Splitting, ultimate failure load and the damage path in center notched composite specimens subjected to in-plane tension loading are predicted using progressive failure analysis methodology. A 2-D Hashin-Rotem failure criterion is used in determining intra-laminar fiber and matrix failures. This progressive failure methodology has been implemented in the Abaqus/Explicit and Abaqus/Standard finite element codes through user written subroutines "VUMAT" and "USDFLD" respectively. A 2-D finite element model is used for predicting the intra-laminar damages. Analysis results obtained from the Abaqus/Explicit and Abaqus/Standard code show good agreement with experimental results. The importance of modeling delamination in progressive failure analysis methodology is recognized for future studies. The use of an explicit integration dynamics code for simple specimen geometry and static loading establishes a foundation for future analyses where complex loading and nonlinear dynamic interactions of damage and structure will necessitate it.

Overview of lower length scale model development for accident tolerant fuels regarding U3Si2 fuel and FeCrAl cladding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yongfeng

2016-09-01

U3Si2 and FeCrAl have been proposed as fuel and cladding concepts, respectively, for accident tolerance fuels with higher tolerance to accident scenarios compared to UO2. However, a lot of key physics and material properties regarding their in-pile performance are yet to be explored. To accelerate the understanding and reduce the cost of experimental studies, multiscale modeling and simulation are used to develop physics-based materials models to assist engineering scale fuel performance modeling. In this report, the lower-length-scale efforts in method and material model development supported by the Accident Tolerance Fuel (ATF) high-impact-problem (HIP) under the NEAMS program are summarized. Significantmore » progresses have been made regarding interatomic potential, phase field models for phase decomposition and gas bubble formation, and thermal conductivity for U3Si2 fuel, and precipitation in FeCrAl cladding. The accomplishments are very useful by providing atomistic and mesoscale tools, improving the current understanding, and delivering engineering scale models for these two ATF concepts.« less

Road safety in Poland: magnitude, causes and injuries.

PubMed

Goniewicz, Krzysztof; Goniewicz, Mariusz; Pawłowski, Witold; Fiedor, Piotr; Lasota, Dorota

2017-01-01

Road accidents are a serious problem of the modern world. They are one of the main causes of injuries and are the third most frequent cause of death. Every year, about one million people, adults and children, die on the roads and several millions get injured. Mortality rate due to injuries from road accidents amounts to 2.2% of all deaths in the world. The research presents epidemiology of road accidents in the period 2004-2015 with particular emphasis on the key issues of road safety in Poland, related to the dangerous behaviour of road users (disregard toward traffic rules). Between years 2004 and 2015 on Polish roads took place more than 508000 accidents with 53155 fatalities and more then 572000 casualties. Despite the various measures which are taken to improve safety on Polish roads, the number of dead and wounded in the vehicle mishap is still large, and losses borne by society are high. To improve safety on Polish roads, it is necessary to continue multi- action plan to systematically progress in the level of road safety.

Phenomenology of BWR fuel assembly degradation

NASA Astrophysics Data System (ADS)

Kurata, Masaki; Barrachin, Marc; Haste, Tim; Steinbrueck, Martin

2018-03-01

Severe accidents occurred at the Fukushima-Daiichi Nuclear Power Station (FDNPS) which required an immediate re-examination of fuel degradation phenomenology. The present paper reviews the updated knowledge on the phenomenology of the fuel degradation, focusing mainly on the BWR fuel assembly degradation at the macroscopic scale and that of the individual interactions at the meso-scale. Oxidation of boron carbide (B4C) control rods potentially generates far larger amounts of heat and hydrogen under BWR accident conditions. All integral tests with B4C control rods or control blades have shown early failure, liquefaction, relocation and oxidation of B4C starting at temperatures around 1250 °C, well below the significant interaction temperatures of UO2-Zry. These interactions or reactions potentially influence the progress of fuel degradation in the early phase. The steam-starved conditions, which are being discussed as a likely scenario at the FDNPS accident, highly influence the individual interactions and potentially lead the fuel degradation in non-prototypical directions. The detailed phenomenology of individual interactions and their influence on the transient and on the late phase of the severe accidents are also discussed.

Effects of Security actions

NASA Astrophysics Data System (ADS)

Bergman, Ramona; Andersson-Sköld, Yvonne; Nyberg, Lars; Johansson, Magnus

2010-05-01

In a project funded by the Swedish Civil Contingencies Agency, the effort and work to reduce different kinds of accidents are being evaluated. The project wants to illuminate the links between actions and outcome, so we can learn from today's performance and in the future select more effective measures and overall deal with accidents more efficiently. The project ESS covers the field of frequent accidents such as sliding accidents at home, in house fires and less common accidents such as chemical and land fill accidents up to even more rare accidents such as natural accidents and hazards. In the ESS project SGI (Swedish geotechnical institute) will evaluate the work and effort concerning various natural hazards limited to landslides, erosion and flooding. The aim is to investigate how municipalities handle, especially prevention, of such natural disasters today. The project includes several aspects such as: • which are the driving forces for risk analysis in a municipality • do one use risk mapping (and what type) in municipal risk analysis • which aspects are most important when selecting preventive measures • in which way do one learn from past accidents • and from previous accidents elsewhere, by for example use existing databases • etc There are many aspects that play a role in a well-functioning safety promotion work. The overall goal is to examine present work and activities, highlight what is well functioning and identify weak points. The aim is to find out where more resources are needed and give suggestions for a more efficient security work. This includes identification of the most efficient "tools" in use or needed. Such tools can be education, directives, funding, more easily available maps and information regarding previous accidents and preventive measures etc. The project will result in recommendations for more effective ways to deal with landslides, erosion and flooding. Since different kinds of problems can occur depending on level of authority the investigation of the security work will be done with authorities on both regional and local scale. At the moment the investigation process are in progress and preliminary results will be presented.

True or false coral snake: is it worth the risk? A Micrurus corallinus case report.

PubMed

Strauch, Marcelo Abrahão; Souza, Guilherme Jones; Pereira, Jordana Nahar; Ramos, Tyelli Dos Santos; Cesar, Marcelo Oliveira; Tomaz, Marcelo Amorim; Monteiro-Machado, Marcos; Patrão-Neto, Fernando Chagas; Melo, Paulo A

2018-01-01

Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus , which together represent almost 80% of accidents. In addition to their less aggressive behavior, habits and morphology of coral snakes are determinant factors for such low incidence of accidents. Although Micrurus bites are rare, victims must be rescued and hospitalized in a short period of time, because this type of envenoming may evolve to a progressive muscle weakness and acute respiratory failure. We report an accident caused by Micrurus corallinus involving a 28-year-old Caucasian sailor man bitten on the hand. The accident occurred in a recreational camp because people believed the snake was not venomous. The victim presented neurological symptoms 2 h after the accident and was taken to the hospital, where he received antielapidic serum 10 h after the bite. After the antivenom treatment, the patient presented clinical evolution without complications and was discharged 4 days later. We reinforce that it is essential to have a health care structure suitable for the treatment of snakebite. Besides, the manipulation of these animals should only be carried out by a team of well-equipped and trained professionals, and even so with special attention.

Analysis of unmitigated large break loss of coolant accidents using MELCOR code

NASA Astrophysics Data System (ADS)

Pescarini, M.; Mascari, F.; Mostacci, D.; De Rosa, F.; Lombardo, C.; Giannetti, F.

2017-11-01

In the framework of severe accident research activity developed by ENEA, a MELCOR nodalization of a generic Pressurized Water Reactor of 900 MWe has been developed. The aim of this paper is to present the analysis of MELCOR code calculations concerning two independent unmitigated large break loss of coolant accident transients, occurring in the cited type of reactor. In particular, the analysis and comparison between the transients initiated by an unmitigated double-ended cold leg rupture and an unmitigated double-ended hot leg rupture in the loop 1 of the primary cooling system is presented herein. This activity has been performed focusing specifically on the in-vessel phenomenology that characterizes this kind of accidents. The analysis of the thermal-hydraulic transient phenomena and the core degradation phenomena is therefore here presented. The analysis of the calculated data shows the capability of the code to reproduce the phenomena typical of these transients and permits their phenomenological study. A first sequence of main events is here presented and shows that the cold leg break transient results faster than the hot leg break transient because of the position of the break. Further analyses are in progress to quantitatively assess the results of the code nodalization for accident management strategy definition and fission product source term evaluation.

Chemistry, manufacturing and control (CMC) and clinical trial technical support for influenza vaccine manufacturers.

PubMed

Wahid, Rahnuma; Holt, Renee; Hjorth, Richard; Berlanda Scorza, Francesco

2016-10-26

With the support of the Biomedical Advanced Research and Development Authority (BARDA) of the US Department of Health and Human Services, PATH has contributed to the World Health Organization's (WHO's) Global Action Plan for Influenza Vaccines (GAP) by providing technical and clinical assistance to several developing country vaccine manufacturers (DCVMs). GAP builds regionally based independent and sustainable influenza vaccine production capacity to mitigate the overall global shortage of influenza vaccines. The program also ensures adequate influenza vaccine manufacturing capacity in the event of an influenza pandemic. Since 2009, PATH has worked closely with two DCVMs in Vietnam: the Institute of Vaccines and Medical Biologicals (IVAC) and VABIOTECH. Beginning in 2013, PATH also began working with Torlak Institute in Serbia; Instituto Butantan in Brazil; Serum Institute of India Private Ltd. in India; and Changchun BCHT Biotechnology Co. (BCHT) in China. The DCVMs supported under the GAP program all had existing influenza vaccine manufacturing capability and required technical support from PATH to improve vaccine yield, process efficiency, and product formulation. PATH has provided customized technical support for the manufacturing process to each DCVM based on their respective requirements. Additionally, PATH, working with BARDA and WHO, supported several DCVMs in the clinical development of influenza vaccine candidates progressing toward national licensure or WHO prequalification. As a result of the activities outlined in this review, several companies were able to make excellent progress in developing state-of-the-art manufacturing processes and completing early phase clinical trials. Licensure trials are currently ongoing or planned for several DCVMs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Bioastronautics Roadmap: A Risk Reduction Strategy for Human Space Exploration

NASA Technical Reports Server (NTRS)

2005-01-01

The Bioastronautics Critical Path Roadmap is the framework used to identify and assess the risks to crews exposed to the hazardous environments of space. It guides the implementation of research strategies to prevent or reduce those risks. Although the BCPR identifies steps that must be taken to reduce the risks to health and performance that are associated with human space flight, the BCPR is not a "critical path" analysis in the strict engineering sense. The BCPR will evolve to accommodate new information and technology development and will enable NASA to conduct a formal critical path analysis in the future. As a management tool, the BCPR provides information for making informed decisions about research priorities and resource allocation. The outcome-driven nature of the BCPR makes it amenable for assessing the focus, progress and success of the Bioastronautics research and technology program. The BCPR is also a tool for communicating program priorities and progress to the research community and NASA management.

The synergic role of sociotechnical and personal characteristics on work injuries in mines.

PubMed

Paul, P S; Maiti, J

2008-05-01

Occupational injuries in mines are attributed to many factors. In this study, an attempt was made to identify the various factors related to work injuries in mines and to estimate their effects on work injuries to mine workers. An accident path model was developed to estimate the pattern and strength of relationships amongst the personal and sociotechnical variables in accident/injury occurrences. The input data for the model were the correlation matrix of 18 variables, which were collected from the case study mines. The case study results showed that there are sequential interactions amongst the sociotechnical and personal factors leading to accidents/injuries in mines. Amongst the latent endogenous constructs, job dissatisfaction and safe work behaviour show a significant positive and negative direct relationship with work injury, respectively. However, the construct safety environment has a significant negative indirect relationship with work injury. The safety environment is negatively affected by work hazards and positively affected by social support. The safety environment also shows a significant negative relationship with job stress and job dissatisfaction. However, negative personality has no significant direct or indirect effect on work injury, but it has a significant negative relationship with safe work behaviour. The endogenous construct negative personality is positively influenced by job stress and negatively influenced by social support.

Aircrew cooperation in the Royal Air Force

NASA Technical Reports Server (NTRS)

Adcock, C. B.

1987-01-01

The progressive introduction of modern, high performance aircraft, coupled with a significant increase in the complexity of the operational environment, has highlighted crew co-operation as a critical factor in aircraft safety. Investigation into recent MAC aircraft accidents supports the conclusion reached by NASA and other U.S. research institutions that a positive training program is required to improve resource management in the cockpit and prevent a breakdown under stress of the crew process. Past training and regulation has concentrated on the attainment of individual flying skills, but group skills have been neglected through lack of knowledge and understanding of the group process. This long-standing deficiency is now being addressed in the U.S. by the progressive and widespread introduction of theoretical and practical training programs to improve crew co-operation. The RAF should provide similar training for its aircrews through the adaptation and development of existing training resources. Better crew co-operation would not only reduce the number of RAF aircraft accidents but also improve the morale of the Service.

Radiological protection from radioactive waste management in existing exposure situations resulting from a nuclear accident.

PubMed

Sugiyama, Daisuke; Hattori, Takatoshi

2013-01-01

In environmental remediation after nuclear accidents, radioactive wastes have to be appropriately managed in existing exposure situations with contamination resulting from the emission of radionuclides by such accidents. In this paper, a framework of radiation protection from radioactive waste management in existing exposure situations for application to the practical and reasonable waste management in contaminated areas, referring to related ICRP recommendations was proposed. In the proposed concept, intermediate reference levels for waste management are adopted gradually according to the progress of the reduction in the existing ambient dose in the environment on the basis of the principles of justification and optimisation by taking into account the practicability of the management of radioactive waste and environmental remediation. It is essential to include the participation of relevant stakeholders living in existing exposure situations in the selection of reference levels for the existing ambient dose and waste management.

Radiological protection from radioactive waste management in existing exposure situations resulting from a nuclear accident

PubMed Central

Sugiyama, Daisuke; Hattori, Takatoshi

2013-01-01

In environmental remediation after nuclear accidents, radioactive wastes have to be appropriately managed in existing exposure situations with contamination resulting from the emission of radionuclides by such accidents. In this paper, a framework of radiation protection from radioactive waste management in existing exposure situations for application to the practical and reasonable waste management in contaminated areas, referring to related ICRP recommendations was proposed. In the proposed concept, intermediate reference levels for waste management are adopted gradually according to the progress of the reduction in the existing ambient dose in the environment on the basis of the principles of justification and optimisation by taking into account the practicability of the management of radioactive waste and environmental remediation. It is essential to include the participation of relevant stakeholders living in existing exposure situations in the selection of reference levels for the existing ambient dose and waste management. PMID:22719047

Risk-based Classification of Incidents

NASA Technical Reports Server (NTRS)

Greenwell, William S.; Knight, John C.; Strunk, Elisabeth A.

2003-01-01

As the penetration of software into safety-critical systems progresses, accidents and incidents involving software will inevitably become more frequent. Identifying lessons from these occurrences and applying them to existing and future systems is essential if recurrences are to be prevented. Unfortunately, investigative agencies do not have the resources to fully investigate every incident under their jurisdictions and domains of expertise and thus must prioritize certain occurrences when allocating investigative resources. In the aviation community, most investigative agencies prioritize occurrences based on the severity of their associated losses, allocating more resources to accidents resulting in injury to passengers or extensive aircraft damage. We argue that this scheme is inappropriate because it undervalues incidents whose recurrence could have a high potential for loss while overvaluing fairly straightforward accidents involving accepted risks. We then suggest a new strategy for prioritizing occurrences based on the risk arising from incident recurrence.

Conceptual design study of Fusion Experimental Reactor (FY86 FER): Safety

NASA Astrophysics Data System (ADS)

Seki, Yasushi; Iida, Hiromasa; Honda, Tsutomu

1987-08-01

This report describes the study on safety for FER (Fusion Experimental Reactor) which has been designed as a next step machine to the JT-60. Though the final purpose of this study is to have an image of design base accident, maximum credible accident and to assess their risk or probability, etc., as FER plant system, the emphasis of this years study is placed on fuel-gas circulation system where the tritium inventory is maximum. The report consists of two chapters. The first chapter summarizes the FER system and describes FMEA (Failure Mode and Effect Analysis) and related accident progression sequence for FER plant system as a whole. The second chapter of this report is focused on fuel-gas circulation system including purification, isotope separation and storage. Probability of risk is assessed by the probabilistic risk analysis (PRA) procedure based on FMEA, ETA and FTA.

Workplace safety in Bangladesh ready-made garment sector: 3 years after the Rana Plaza collapse.

PubMed

Barua, Uttama; Ansary, Mehedi Ahmed

2017-12-01

Workplace safety is one of the most important issues in industries worldwide, and is endangered by industrial accidents. Different industrial disasters have resulted in several initiatives worldwide to protect human life and reduce material damage, both nationally and internationally. In Bangladesh, the ready-made garment (RMG) industry is one of the most important export-oriented business sectors, which is facing challenges to ensure workplace safety. The Rana Plaza collapse in Bangladesh is the consequence of such non-compliance. The accident resulted in different local and global initiatives to address the challenges. This article reviews progress and achievement of the initiatives to reduce vulnerability in the Bangladesh RMG industry within 3 years after the deadly accident. In the long run, the challenge is to maintain momentum already created for achieving sustainability in the RMG sector in Bangladesh and maintaining compliance even after the end of support from external partners.

Analysis for the Progressive Failure Response of Textile Composite Fuselage Frames

NASA Technical Reports Server (NTRS)

Johnson, Eric R.; Boitnott, Richard L. (Technical Monitor)

2002-01-01

A part of aviation accident mitigation is a crashworthy airframe structure, and an important measure of merit for a crashworthy structure is the amount of kinetic energy that can be absorbed in the crush of the structure. Prediction of the energy absorbed from finite element analyses requires modeling the progressive failure sequence. Progressive failure modes may include material degradation, fracture and crack growth, and buckling and collapse. The design of crashworthy airframe components will benefit from progressive failure analyses that have been validated by tests. The subject of this research is the development of a progressive failure analysis for a textile composite, circumferential fuselage frame subjected to a quasi-static, crash-type load. The test data for the frame are reported, and these data are used to develop and to validate methods for the progressive failure response.

Apparatus for controlling nuclear core debris

DOEpatents

Jones, Robert D.

1978-01-01

Nuclear reactor apparatus for containing, cooling, and dispersing reactor debris assumed to flow from the core area in the unlikely event of an accident causing core meltdown. The apparatus includes a plurality of horizontally disposed vertically spaced plates, having depressions to contain debris in controlled amounts, and a plurality of holes therein which provide natural circulation cooling and a path for debris to continue flowing downward to the plate beneath. The uppermost plates may also include generally vertical sections which form annular-like flow areas which assist the natural circulation cooling.

Military Career Paths. Career Progression Patterns for Selected Occupations from the Military Career Guide.

ERIC Educational Resources Information Center

Military Entrance Processing Command (DOD), North Chicago, IL.

This document was developed in response to requests from guidance professionals for information about career progression in the military. It presents descriptions of typical career development patterns over a 20-year period for 25 enlisted and 13 officer occupations. The enlisted occupations are: administrative support specialists, air crew…

A Safe and Welcoming Place?: Workplace Progression for Women Staff.

ERIC Educational Resources Information Center

Gardiner, Jean; O'Rourke, Rebecca

1995-01-01

Interviews with seven women lecturers and five administrative/library staff at Leeds University uncovered the following: differential career paths for women and men; a link between the extent of career progression and working full or part time; and few opportunities for gender issues to be openly discussed in the academic workplace. (SK)

Some Tests and Calculations Pertaining to the Dive Path and to Wing and Tail Loads in the Accident to Eastern Airlines C54B Airplane, NC-88814, Near Bainbridge, Maryland, May 30, 1947

NASA Technical Reports Server (NTRS)

Rhode, Richard V.; Stokke, Allen R.; Rogin, Leo

1947-01-01

Several dive paths were calculated for a C54 airplane starting from level flight at an altitude of 4000 feet and from an initial indicated airspeed of 200 miles per hour. The results show that, within the limits of the possible paths permitted by the evidence of the crash at Bainbridge, the speed of impact would be about 370 miles per hour and the time to crash would be between 12 1/2 and 15 1/2 seconds. Tail load calculations indicate that, with moderate negative acceleration of the airplane, the tail would fail near the end of the dive in a manner consistent in several important respects with the evidence. A number of tests were made of the elevator tab control system to determine whether the tab would move by an amount sufficient to have caused the observed dive if the stored energy in the tab control cable were suddenly released. The results of these tests indicated that the probable tab movement is such as to be capable of causing a dive similar to the one observed at Bainbridge.

Severe Accident Sequence Analysis Program: Anticipated transient without scram simulations for Browns Ferry Nuclear Plant Unit 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dallman, R J; Gottula, R C; Holcomb, E E

1987-05-01

An analysis of five anticipated transients without scram (ATWS) was conducted at the Idaho National Engineering Laboratory (INEL). The five detailed deterministic simulations of postulated ATWS sequences were initiated from a main steamline isolation valve (MSIV) closure. The subject of the analysis was the Browns Ferry Nuclear Plant Unit 1, a boiling water reactor (BWR) of the BWR/4 product line with a Mark I containment. The simulations yielded insights to the possible consequences resulting from a MSIV closure ATWS. An evaluation of the effects of plant safety systems and operator actions on accident progression and mitigation is presented.

Proactive assessment of accident risk to improve safety on a system of freeways : [research brief].

DOT National Transportation Integrated Search

2012-05-01

As traffic safety on freeways continues to be a growing concern, much progress has been made in shifting from reactive (incident detection) to proactive (real-time crash risk assessment) traffic strategies. Reliable models that can take in real-time ...

Korean Air Lines Flight 007: Lessons from the Past and Insights for the Future

NASA Technical Reports Server (NTRS)

Degani, Asaf; Shafto, M. (Technical Monitor)

2001-01-01

The majority of the problems pilot encounter when using automated systems center around two factors: (1) the pilot has an incomplete and inadequate model of how the autopilot works; and (2) the displays and flight manuals, provided to the pilot, are inadequate for the task. The tragic accident of Korean Air Lines Flight 007, a Boeing 747 that deviated from its intended flight path, provides a compelling case-study of problems related to pilots' use of automated systems. This paper describes what had happened and exposes two types of human-automation interaction problems: (1) The pilots of KAL were not provided with adequate information about the actual behavior of the autopilot and its mode transition logic; and (2) The autopilot onboard KAL 007 did not provide adequate information to the flight crew about its active and armed modes. Both factors, according to the International Civil Aviation Organization (1993) report on the accident, contributed to the aircraft's lethal navigation error.

NSRD-10: Leak Path Factor Guidance Using MELCOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Louie, David; Humphries, Larry L.

Estimates of the source term from a U.S. Department of Energy (DOE) nuclear facility requires that the analysts know how to apply the simulation tools used, such as the MELCOR code, particularly for a complicated facility that may include an air ventilation system and other active systems that can influence the environmental pathway of the materials released. DOE has designated MELCOR 1.8.5, an unsupported version, as a DOE ToolBox code in its Central Registry, which includes a leak-path-factor guidance report written in 2004 that did not include experimental validation data. To continue to use this MELCOR version requires additional verificationmore » and validations, which may not be feasible from a project cost standpoint. Instead, the recent MELCOR should be used. Without any developer support and lack of experimental data validation, it is difficult to convince regulators that the calculated source term from the DOE facility is accurate and defensible. This research replaces the obsolete version in the 2004 DOE leak path factor guidance report by using MELCOR 2.1 (the latest version of MELCOR with continuing modeling development and user support) and by including applicable experimental data from the reactor safety arena and from applicable experimental data used in the DOE-HDBK-3010. This research provides best practice values used in MELCOR 2.1 specifically for the leak path determination. With these enhancements, the revised leak-path-guidance report should provide confidence to the DOE safety analyst who would be using MELCOR as a source-term determination tool for mitigated accident evaluations.« less

Obtaining parsimonious hydraulic conductivity fields using head and transport observations: A Bayesian geostatistical parameter estimation approach

NASA Astrophysics Data System (ADS)

Fienen, M.; Hunt, R.; Krabbenhoft, D.; Clemo, T.

2009-08-01

Flow path delineation is a valuable tool for interpreting the subsurface hydrogeochemical environment. Different types of data, such as groundwater flow and transport, inform different aspects of hydrogeologic parameter values (hydraulic conductivity in this case) which, in turn, determine flow paths. This work combines flow and transport information to estimate a unified set of hydrogeologic parameters using the Bayesian geostatistical inverse approach. Parameter flexibility is allowed by using a highly parameterized approach with the level of complexity informed by the data. Despite the effort to adhere to the ideal of minimal a priori structure imposed on the problem, extreme contrasts in parameters can result in the need to censor correlation across hydrostratigraphic bounding surfaces. These partitions segregate parameters into facies associations. With an iterative approach in which partitions are based on inspection of initial estimates, flow path interpretation is progressively refined through the inclusion of more types of data. Head observations, stable oxygen isotopes (18O/16O ratios), and tritium are all used to progressively refine flow path delineation on an isthmus between two lakes in the Trout Lake watershed, northern Wisconsin, United States. Despite allowing significant parameter freedom by estimating many distributed parameter values, a smooth field is obtained.

Obtaining parsimonious hydraulic conductivity fields using head and transport observations: A Bayesian geostatistical parameter estimation approach

USGS Publications Warehouse

Fienen, M.; Hunt, R.; Krabbenhoft, D.; Clemo, T.

2009-01-01

Flow path delineation is a valuable tool for interpreting the subsurface hydrogeochemical environment. Different types of data, such as groundwater flow and transport, inform different aspects of hydrogeologic parameter values (hydraulic conductivity in this case) which, in turn, determine flow paths. This work combines flow and transport information to estimate a unified set of hydrogeologic parameters using the Bayesian geostatistical inverse approach. Parameter flexibility is allowed by using a highly parameterized approach with the level of complexity informed by the data. Despite the effort to adhere to the ideal of minimal a priori structure imposed on the problem, extreme contrasts in parameters can result in the need to censor correlation across hydrostratigraphic bounding surfaces. These partitions segregate parameters into facies associations. With an iterative approach in which partitions are based on inspection of initial estimates, flow path interpretation is progressively refined through the inclusion of more types of data. Head observations, stable oxygen isotopes (18O/16O ratios), and tritium are all used to progressively refine flow path delineation on an isthmus between two lakes in the Trout Lake watershed, northern Wisconsin, United States. Despite allowing significant parameter freedom by estimating many distributed parameter values, a smooth field is obtained.

Travels of "Sound"

ERIC Educational Resources Information Center

Raghuraman, Renuka Sundaram

2009-01-01

Some children are born with a hearing loss. Other children, initially, hear normally, but progressively lose their hearing over time. Other reasons for hearing loss include illness, accidents, genes, trauma, or, simply, a fluke of nature. With the right tools and optimal intervention, most children adapt well and lead active lives just like anyone…

Analysis for the Progressive Failure Response of Textile Composite Fuselage Frames

NASA Technical Reports Server (NTRS)

Johnson, Eric R.; Boitnott, Richard L. (Technical Monitor)

2002-01-01

A part of aviation accident mitigation is a crash worthy airframe structure, and an important measure of merit for a crash worthy structure is the amount of kinetic energy that can be absorbed in the crush of the structure. Prediction of the energy absorbed from finite element analyses requires modeling the progressive failure sequence. Progressive failure modes may include material degradation, fracture and crack growth, and buckling and collapse. The design of crash worthy airframe components will benefit from progressive failure analyses that have been validated by tests. The subject of this research is the development of a progressive failure analysis for textile composite. circumferential fuselage frames subjected to a quasi-static, crash-type load. The test data for these frames are reported, and these data, along with stub column test data, are to be used to develop and to validate methods for the progressive failure response.

49 CFR 213.113 - Defective rails.

Code of Federal Regulations, 2014 CFR

2014-10-01

... across the web, originating from a bolt hole, and progressing on a path either inclined upward toward the... horizontally along the head/web or base/web fillet, or they may progress into and through the head or base to... depression is visible on the rail head only, the sagging or drooping is also visible in the head/web fillet...

Validity of thyroid cancer incidence data following the Chernobyl accident.

PubMed

Jargin, Sergei V

2011-12-01

The only clearly demonstrated cancer incidence increase that can be attributed to radiation from the Chernobyl accident is thyroid carcinoma in patients exposed during childhood or adolescence. Significant increases in thyroid disease were observed as soon as 4 y after the accident. The solid/follicular subtype of papillary carcinoma predominated in the early period after the accident. Morphological diagnosis of cancer in such cases, if no infiltrative growth is clearly visible, depends mainly on the nuclear criteria. Outdated equipment and insufficient quality of histological specimens impeded reliable evaluation of the nuclear criteria. Access to foreign professional literature has always been limited in the former Soviet Union. The great number of advanced tumors observed shortly after the accident can be explained by the screening effect (detection of previously neglected cancers) and by the fact that many patients were brought from non-contaminated areas and registered as Chernobyl victims. It is also worth noting that exaggeration of the Chernobyl cancer statistics facilitated the writing of dissertations, financing of research, and assistance from outside the former Soviet Union. "Chernobyl hysteria" impeded nuclear energy production in some countries, thus contributing to higher prices for fossil fuel. The concluding point is that since post-Chernobyl cancers tend on average to be in a later stage of tumor progression, some published data on molecular or immunohistochemical characteristics of Chernobyl-related cancers require reevaluation.

A model for the progressive failure of laminated composite structural components

NASA Technical Reports Server (NTRS)

Allen, D. H.; Lo, D. C.

1991-01-01

Laminated continuous fiber polymeric composites are capable of sustaining substantial load induced microstructural damage prior to component failure. Because this damage eventually leads to catastrophic failure, it is essential to capture the mechanics of progressive damage in any cogent life prediction model. For the past several years the authors have been developing one solution approach to this problem. In this approach the mechanics of matrix cracking and delamination are accounted for via locally averaged internal variables which account for the kinematics of microcracking. Damage progression is predicted by using phenomenologically based damage evolution laws which depend on the load history. The result is a nonlinear and path dependent constitutive model which has previously been implemented to a finite element computer code for analysis of structural components. Using an appropriate failure model, this algorithm can be used to predict component life. In this paper the model will be utilized to demonstrate the ability to predict the load path dependence of the damage and stresses in plates subjected to fatigue loading.

Navigation skill impairment: Another dimension of the driving difficulties in minimal hepatic encephalopathy.

PubMed

Bajaj, Jasmohan S; Hafeezullah, Muhammad; Hoffmann, Raymond G; Varma, Rajiv R; Franco, Jose; Binion, David G; Hammeke, Thomas A; Saeian, Kia

2008-02-01

Patients with minimal hepatic encephalopathy (MHE) have attention, response inhibition, and working memory difficulties that are associated with driving impairment and high motor vehicle accident risk. Navigation is a complex system needed for safe driving that requires functioning working memory and other domains adversely affected by MHE. The aim of this study was to determine the effect of MHE on navigation skills and correlate them with psychometric impairment. Forty-nine nonalcoholic patients with cirrhosis (34 MHE+, 15 MHE-; divided on the basis of a battery of block design, digit symbol, and number connection test A) and 48 age/education-matched controls were included. All patients underwent the psychometric battery and inhibitory control test (ICT) (a test of response inhibition) and driving simulation. Driving simulation consisted of 4 parts: (1) training; (2) driving (outcome being accidents); (3) divided attention (outcome being missed tasks); and (4) navigation, driving along a marked path on a map in a "virtual city" (outcome being illegal turns). Illegal turns were significantly higher in MHE+ (median 1; P = 0.007) compared with MHE-/controls (median 0). Patients who were MHE+ missed more divided attention tasks compared with others (median MHE+ 1, MHE-/controls 0; P = 0.001). Similarly, accidents were higher in patients who were MHE+ (median 2.5; P = 0.004) compared with MHE- (median 1) or controls (median 2). Accidents and illegal turns were significantly correlated (P = 0.001, r = 0.51). ICT impairment was the test most correlated with illegal turns (r = 0.6) and accidents (r = 0.44), although impairment on the other tests were also correlated with illegal turns. Patients positive for MHE have impaired navigation skills on a driving simulator, which is correlated with impairment in response inhibition (ICT) and attention. This navigation difficulty may pose additional driving problems, compounding the pre-existing deleterious effect of attention deficits.

The effects of aircraft certification rules on general aviation accidents

NASA Astrophysics Data System (ADS)

Anderson, Carolina Lenz

The purpose of this study was to analyze the frequency of general aviation airplane accidents and accident rates on the basis of aircraft certification to determine whether or not differences in aircraft certification rules had an influence on accidents. In addition, the narrative cause descriptions contained within the accident reports were analyzed to determine whether there were differences in the qualitative data for the different certification categories. The certification categories examined were: Federal Aviation Regulations Part 23, Civil Air Regulations 3, Light Sport Aircraft, and Experimental-Amateur Built. The accident causes examined were those classified as: Loss of Control, Controlled Flight into Terrain, Engine Failure, and Structural Failure. Airworthiness certification categories represent a wide diversity of government oversight. Part 23 rules have evolved from the initial set of simpler design standards and have progressed into a comprehensive and strict set of rules to address the safety issues of the more complex airplanes within the category. Experimental-Amateur Built airplanes have the least amount of government oversight and are the fastest growing segment. The Light Sport Aircraft category is a more recent certification category that utilizes consensus standards in the approval process. Civil Air Regulations 3 airplanes were designed and manufactured under simpler rules but modifying these airplanes has become lengthy and expensive. The study was conducted using a mixed methods methodology which involves both quantitative and qualitative elements. A Chi-Square test was used for a quantitative analysis of the accident frequency among aircraft certification categories. Accident rate analysis of the accidents among aircraft certification categories involved an ANCOVA test. The qualitative component involved the use of text mining techniques for the analysis of the narrative cause descriptions contained within the accident reports. The Chi-Square test indicated that there was no significant difference in the number of accidents among the different certification categories when either Controlled Flight into Terrain or Structural Failure was listed as cause. However, there was a significant difference in the frequency of accidents with regard to Loss of Control and Engine Failure accidents. The results of the ANCOVA test indicated that there was no significant difference in the accident rate with regard to Loss of Control, Controlled Flight into Terrain, or Structural Failure accidents. There was, however, a significant difference in Engine Failure accidents between Experimental-Amateur Built and the other categories.The text mining analysis of the narrative causes of Loss of Control accidents indicated that only the Civil Air Regulations 3 category airplanes had clusters of words associated with visual flight into instrument meteorological conditions. Civil Air Regulations 3 airplanes were designed and manufactured prior to the 1960s and in most cases have not been retrofitted to take advantage of newer technologies that could help prevent Loss of Control accidents. The study indicated that General Aviation aircraft certification rules do not have a statistically significant effect on aircraft accidents except for Loss of Control and Engine Failure. According to the literature, government oversight could have become an obstacle in the implementation of safety enhancing equipment that could reduce Loss of Control accidents. Oversight should focus on ensuring that Experimental-Amateur Built aircraft owners perform a functional test that could prevent some of the Engine Failure accidents.

Comparison of MELCOR and SCDAP/RELAP5 results for a low-pressure, short-term station blackout at Browns Ferry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carbajo, J.J.

1995-12-31

This study compares results obtained with two U.S. Nuclear Regulatory Commission (NRC)-sponsored codes, MELCOR version 1.8.3 (1.8PQ) and SCDAP/RELAP5 Mod3.1 release C, for the same transient - a low-pressure, short-term station blackout accident at the Browns Ferry nuclear plant. This work is part of MELCOR assessment activities to compare core damage progression calculations of MELCOR against SCDAP/RELAP5 since the two codes model core damage progression very differently.

Cranial injury caused by penetrating non-missile foreign body: an autopsy case.

PubMed

Eren, B; Türkmen, N; Toprak Ergönen, A; Gündogmus, U N

2012-10-01

Presented case was 32-year-old male marble worker, who underwent industrial accident at workplace. On gross physical examination; on forehead region round skin wound in 0.9 cm diameter was detected, radiological examination showed the image of metallic object. in the skull cavity. Brain dissection showed obvious brain injury, haemorrahge explaining the pattern of injury caused by the metallic bodys path, from left frontal lobe to the left cerebellar hemisphere was identified. We presented rare case of penetrating injury of the cranial region caused by non-missile foreign body. cranial injury - non-missile foreign body - autopsy.

[Stingrays in rivers in southeastern Brazil: occurrence localities and impact on the population].

PubMed

Garrone Neto, Domingos; Haddad Junior, Vidal

2010-01-01

In this paper, our aim was to describe the process of colonization of the upper Paraná basin, southeastern Brazil, by stingrays, showing the current situation, likely trend and impact caused and discussing some management actions and mitigation measures. Interviews were held with riverbank people and health professionals, to gather information on occurrences of stingrays and accidents associated with these animals, along with underwater observations and collection of specimens, between 2004 and 2009 in localities in the States of São Paulo, Paraná and Mato Grosso do Sul, in the southeastern, southern and part of the central-western regions of Brazil. Three species of stingrays were identified in the study area, thus demonstrating that they were using the paths opened by the Tietê-Paraná Waterway to disperse. Sixteen victims of accidents involving these animals were found, mainly bathers and fishermen. Attention was drawn to the fact that these cases had not been reported, yet they presented high morbidity with notable temporary incapacity for work. This is the first report on biological invasion involving species of elasmobranchs in the literature and, because stingrays are colonizing densely populated areas and are expanding their range of distribution each year, it can be expected that their negative interactions with humans will intensify, with important changes in the epidemiological profile of accidents due to venomous animals occurring in southeastern Brazil.

Evidence for self-refraction in a convergence zone: NPE (Nonlinear progressive wave equation) model results

NASA Technical Reports Server (NTRS)

Mcdonald, B. Edward; Plante, Daniel R.

1989-01-01

The nonlinear progressive wave equation (NPE) model was developed by the Naval Ocean Research and Development Activity during 1982 to 1987 to study nonlinear effects in long range oceanic propagation of finite amplitude acoustic waves, including weak shocks. The NPE model was applied to propagation of a generic shock wave (initial condition provided by Sandia Division 1533) in a few illustrative environments. The following consequences of nonlinearity are seen by comparing linear and nonlinear NPE results: (1) a decrease in shock strength versus range (a well-known result of entropy increases at the shock front); (2) an increase in the convergence zone range; and (3) a vertical meandering of the energy path about the corresponding linear ray path. Items (2) and (3) are manifestations of self-refraction.

The Long Path to Higher Education for African Americans

ERIC Educational Resources Information Center

Duster, Troy

2009-01-01

When one considers the possibilities for a new progressive era in American higher education, the author contends that it is wise to review the past because there are lessons to be learned. In fact, the latter part of the 20th century was one of great progress for diversity in higher education, generally speaking, and for African Americans in…

Analysis of accidents and injuries on motorcycles in Mexico.

PubMed

Berrones-Sanz, Luis David

2017-01-01

To analyze the type of injuries and the characteristics and geographical distribution of road accidents where motorcycles were involved in Mexico. A descriptive analysis of second-hand information sources was conducted, including the number of accidents (N = 41,881), total number of injured people (N = 13,916) and medical expenses (N = 9,111) associated to motorcycle accidents during 2014. Motorcycles represent 13.14% of the total number of deaths in road accidents in Mexico, and the Southeast region of Mexico registers the highest proportion of fatal injuries. Of the total number of motorcycles, 1.84% (95% confidence interval [CI]: 1.83-1.86) were involved in a collision. 3.64 (95% CI: 3.39-3.89) people died and 105.5 (95% CI: 104.1-106.8) were injured in every 10,000. Out of the total number of injuries, 76.6% were male and 53.74% were women. 55.1% of deaths were caused by intracranial trauma. Only 16.6% wore a helmet at the time of the accident, and those not wearing a helmet had a 2.11 (odds ratio [OR]: 2.1; CI 95%: 1.8-2.4) higher chance of head injury. Regarding the severity of the crash, those occurred in suburban areas (OR: 6.58; CI 95%: 5.69-7.60), in unpaved surfaces (OR: 4.13; CI 95%: 3.04-5.61), after low alcohol consumption (OR: 1.89; CI 95%: 1.46-2.44), at night (OR: 2.24; CI 95%: 1.95-2.57) and on weekends (OR: 1.65; CI 95%: 1.44-1.90), had the highest chance of turning into a fatal accident. In spite of the progress made in terms of road safety, motorcycle accidents are still increasing, and the use of a helmet is still proportionally low. More information on these groups and risk factors needs to be available so people are better informed. Also, regulations need improvements regarding the use of security equipment like helmets in order to reduce injuries and fatal accidents.

Improving Freight Fire Safety: Analysis and Testing of Real Engine Conditions to Progress Development of Mist-controlling Additives for Fire Mitigation

DOT National Transportation Integrated Search

2009-12-01

The formation of a fuel mist resulting from high shear stresses acting on the fuel during violent sloshing and tank rupture under the energy of a crash severely increases the occurrence and intensity of fires in transportation related accidents. In o...

Access and Opportunities to Learn Are Not Accidents: Engineering Mathematical Progress in Your School

ERIC Educational Resources Information Center

Tate. William F., IV

2005-01-01

This monograph represents an effort to build upon and extend beyond the literature on school mathematics as discussed in "Mathematics and Science: Critical Filters for the Future." Three significant changes in the political and educational landscape since 1985 are discussed. The first change is the introduction of mathematics standards…

Toward an Understanding of Adolescent Parasuicide.

ERIC Educational Resources Information Center

Greenlee, Lynn Franklin, Jr.

In the 1960s suicide was the fifth leading cause of death among adolescents. In the 1980s suicide is second only to accidents as a cause of adolescent death. In their 1966 study of 50 adolescents who had attempted suicide, Teicher and Jacobs conceptualized suicide as the end product of progressive isolation from meaningful relationships. From…

[Increasing Number of Road Traffic Fatalities in Germany - Turnaround or Snap-Shot].

PubMed

Brand, S; Schmucker, U; Lob, G; Haasper, C; Juhra, C; Hell, W; Rieth, P; Matthes, G

2017-04-01

Introduction: For the first time since 20 years, the number of road accident fatalities in 2011 increased on German roads compared to earlier periods. Methods and Results: The presented paper submitted by the expert group for accident prevention investigates and discusses possible reasons for the observed increase in road traffic fatalities. Results: Climate changes as well as changes in economic environment, and technological progress in car and passenger safety are identified as possible reasons for the observed increase. Discussion: Mentioning the "Decade of Action for Road Safety" initiated by the UNO and coordinated by the WHO, the overall goal is a worldwide reduction of accident related road fatalities. But prognostic calculations predict an asymptotic approximation to a limit of road fatalities. To achieve a reduction by half until 2020 intense collaboration and disproportional expenditure are necessary. Conclusion: From the authors' point of view the current increase of traffic fatalities in Germany is rated as a snapshot rather than a turnaround. Georg Thieme Verlag KG Stuttgart · New York.

Assessment of Technogenic Accident Risk of Industrial Building Structures

NASA Astrophysics Data System (ADS)

Baiburin, D. A.; Baiburin, A. Kh

2017-11-01

A methodology for assessing the risk of an industrial building accident was developed taking into account the damage caused by various localization of collapse. Before the beginning of the survey of a facility technical condition, groups including the same type of building structures are selected. Further, assessment is made for the reduction in their load-carrying capacity from the strength and stability conditions taking into account defects. The characteristics of the influence of defects and structural damage on a building safety is the degree of compliance with the standards expressed by the reliability level. Reliability levels assignment is carried out on the basis of calculations, operating experience and inspection of a particular type of structure according to the formalized rules. The risk of collapse according to a separate scenario is calculated for structures that are capable and incapable of causing a progressive ossification. The results of the technique application are based on the analysis of the accident risk at the welding shop “Vysota (Height) 239” of the Chelyabinsk Pipe Rolling Plant.

Epidemiological patterns of ocular trauma.

PubMed

Thylefors, B

1992-05-01

Ocular trauma is the cause of blindness in approximately half a million people worldwide, and many more have suffered partial loss of sight. Trauma is often the most important cause of unilateral loss of vision, particularly in developing countries. There is a cumulative risk of ocular trauma and visual loss during life, but the true incidence of accidents involving the eyes is not known. Males tend to have more eye trauma than females, and this is already apparent from childhood; lower socioeconomic classes are also more associated with ocular trauma. The setting for the occurrence of trauma is most commonly the workplace and, increasingly, road accidents. On the other hand, domestic accidents are probably under-reported. Of particular importance in some developing countries is the occurrence of superficial corneal trauma in agricultural work, often leading to rapidly progressing corneal ulceration and visual loss. The impact of ocular trauma, in terms of need for medical care, loss of income and cost of rehabilitation services when indicated, clearly makes the strengthening of preventive measures very worthwhile.

From Devastation to Recovery and Revival in the Aftermath of Fukushima's Nuclear Power Plants Accident.

PubMed

Ohto, Hitoshi; Yasumura, Seiji; Maeda, Masaharu; Kainuma, Hiroshi; Fujimori, Keiya; Nollet, Kenneth E

2017-03-01

Japan's earthquake, tsunami, and subsequent Fukushima nuclear power plant accident in March 2011 forced the evacuation of 185 000 residents. Psychological and social impacts exacerbated by long-term evacuation and widespread rumors have influenced residents' physical and mental health, despite the fact that no direct fatalities occurred from radiation exposure. However, during the 5 years following the accident, steady recovery in industrial and economic activity has lessened previously widespread, deeply rooted stigma and self-stigma among a significant number of affected victims. More than 21 000 of 62 800 people who evacuated from Fukushima are gradually returning, and concurrently, Fukushima's economic and social recovery are progressing, as can be seen from remarkable increases in residential construction, recovering agricultural production, job growth, and industrial output. Although post-disaster interventions such as seminars and dialogues with residents are credited with building resilience, a significant proportion of people in the area have depressive tendencies and loss of purpose.

Nuclear reactor pressure vessel support system

DOEpatents

Sepelak, George R.

1978-01-01

A support system for nuclear reactor pressure vessels which can withstand all possible combinations of stresses caused by a postulated core disrupting accident during reactor operation. The nuclear reactor pressure vessel is provided with a flange around the upper periphery thereof, and the flange includes an annular vertical extension formed integral therewith. A support ring is positioned atop of the support ledge and the flange vertical extension, and is bolted to both members. The plug riser is secured to the flange vertical extension and to the top of a radially outwardly extension of the rotatable plug. This system eliminates one joint through which fluids contained in the vessel could escape by making the fluid flow path through the joint between the flange and the support ring follow the same path through which fluid could escape through the plug risers. In this manner, the sealing means to prohibit the escape of contained fluids through the plug risers can also prohibit the escape of contained fluid through the securing joint.

The relationship between social capital and traffic law violations: Israeli Arabs as a case study.

PubMed

Obeid, Samira; Gitelman, Victoria; Baron-Epel, Orna

2014-10-01

Social aspects of a community may be correlated with driver's involvement in road traffic accidents. This study focused on examining this association in the context of the social capital theory. A survey of 600 Arab drivers living in 19 towns and villages was conducted using a face-to-face interview. Structural equation modeling was applied to explore paths of associations between the model components. Most of the proposed relationships in the path model were found to be significant, where the model explained 37% of the variation. The results indicate that only volunteering and reciprocity have direct correlations with traffic law violations. While the other correlations (except political involvement), were mediated by attitudes toward traffic laws violation. Hence, it can be concluded that it is not always possible to generalize the positive mechanisms of the social capital theory, and in certain populations such as the Arab minority it can give undesirable results. Copyright © 2014 Elsevier Ltd. All rights reserved.

Autonomous Control Modes and Optimized Path Guidance for Shipboard Landing in High Sea States

DTIC Science & Technology

2016-04-28

Contract # N00014-14-C-0004 Autonomous Control Modes and Optimized Path Guidance for Shipboard Landing in High Sea States Progress Report...Aviation (ONR BAA12-SN-0028). This project addresses the Sea Based Aviation (SBA) initiative in Advanced Handling Qualities for Rotorcraft. Landing a...and a degraded visual environment, workload during the landing task begins to approach the limits of a human pilot’s capability. It is a similarly

Multivariate statistical analysis and hydrogeochemical modelling of seawater-freshwater mixing along selected flow paths: Case of Korba coastal aquifer Tunisia

NASA Astrophysics Data System (ADS)

Slama, Fairouz; Bouhlila, Rachida

2017-11-01

Groundwater sampling and piezometric measurements were carried out along two flow paths (corresponding to two transects) in Korba coastal plain (Northeast of Tunisia). The study aims to identify hydrochemical processes occurring when seawater and freshwater mix. Those processes can be used as indicators of seawater intrusion progression and freshwater flushing into seawater accompanying Submarine Groundwater Discharge (SGD). Seawater fractions in the groundwater were calculated using the chloride concentration. Hierarchical cluster analysis (HCA) was applied to isolate wells potentially affected by seawater. In addition, PHREEQC was used to simulate the theoretical mixing between two end members: seawater and a fresh-brackish groundwater sample. Geochemical conventional diagrams showed that the groundwater chemistry is explained by a mixing process between two end members. Results also revealed the presence of other geochemical processes, correlated to the hydrodynamic flow paths. Direct cation exchange was linked to seawater intrusion, and reverse cation exchange was associated to the freshwater flushing into seawater. The presence of these processes indicated that seawater intrusion was in progress. An excess of Ca, that could not be explained by only cation exchange processes, was observed in both transects. Dedolomitization combined to gypsum leaching is the possible explanation of the groundwater Ca enrichment. Finally, redox processes were also found to contribute to the groundwater composition along flow paths.

Bridging the Gap: The 'Soft Path' for Improving Resilience and Adaptability of Water Systems (Invited)

NASA Astrophysics Data System (ADS)

Gleick, P. H.

2010-12-01

The failure of traditional water management systems in the 20th century -- what I call the "hard path for water" -- is evident in several ways, including the persistent inability to meet basic human needs for safe water and adequate sanitation for vast populations, ongoing and accelerating aquatic ecosystem collapses , and growing political disputes over water allocation, management, and use, even in regions where substantial investment in water has been made. Progress in resolving these problems, especially in the face of unavoidable climate changes, growing populations, and constrained financial systems, will require bridging hydrologic and social sciences in new ways. Integrating social and cultural knowledge with new economic and technological tools and classical hydrologic and climatological sciences can produce a new “soft path for water” that offers the opportunity to move toward sustainable water systems. This talk will define the soft path for water and offer examples of innovative steps already being taken along that path in the western United States, South Africa, India, and elsewhere.

The Happy and Suffering Student? Rousseau's "Emile" and the Path Not Taken in Progressive Educational Thought

ERIC Educational Resources Information Center

Mintz, Avi I.

2012-01-01

One of the mantras of progressive education is that genuine learning ought to be exciting and pleasurable, rather than joyless and painful. To a significant extent, Jean-Jacques Rousseau is associated with this mantra. In a theme of "Emile" that is often neglected in the educational literature, however, Rousseau stated that "to suffer is the first…

Cancer rates after the Three Mile Island nuclear accident and proximity of residence to the plant.

PubMed Central

Hatch, M C; Wallenstein, S; Beyea, J; Nieves, J W; Susser, M

1991-01-01

BACKGROUND: In the light of a possible link between stress and cancer promotion or progression, and of previously reported distress in residents near the Three Mile Island (TMI) nuclear power plant, we attempted to evaluate the impact of the March 1979 accident on community cancer rates. METHODS: Proximity of residence to the plant, which related to distress in previous studies, was taken as a possible indicator of accident stress; the postaccident pattern in cancer rates was examined in 69 "study tracts" within a 10-mile radius of TMI, in relation to residential proximity. RESULTS: A modest association was found between postaccident cancer rates and proximity (OR = 1.4; 95% CI = 1.3, 1.6). After adjusting for a gradient in cancer risk prior to the accident, the odds ratio contrasting those closest to the plant with those living farther out was 1.2 (95% CI = 1.0, 1.4). A postaccident increase in cancer rates near the Three Mile Island plant was notable in 1982, persisted for another year, and then declined. Radiation emissions, as modeled mathematically, did not account for the observed increase. CONCLUSION: Interpretation in terms of accident stress is limited by the lack of an individual measure of stress and by uncertainty about whether stress has a biological effect on cancer in humans. An alternative mechanism for the cancer increase near the plant is through changes in care-seeking and diagnostic practice arising from postaccident concern. PMID:2029040

Cancer rates after the Three Mile Island nuclear accident and proximity of residence to the plant.

PubMed

Hatch, M C; Wallenstein, S; Beyea, J; Nieves, J W; Susser, M

1991-06-01

In the light of a possible link between stress and cancer promotion or progression, and of previously reported distress in residents near the Three Mile Island (TMI) nuclear power plant, we attempted to evaluate the impact of the March 1979 accident on community cancer rates. Proximity of residence to the plant, which related to distress in previous studies, was taken as a possible indicator of accident stress; the postaccident pattern in cancer rates was examined in 69 "study tracts" within a 10-mile radius of TMI, in relation to residential proximity. A modest association was found between postaccident cancer rates and proximity (OR = 1.4; 95% CI = 1.3, 1.6). After adjusting for a gradient in cancer risk prior to the accident, the odds ratio contrasting those closest to the plant with those living farther out was 1.2 (95% CI = 1.0, 1.4). A postaccident increase in cancer rates near the Three Mile Island plant was notable in 1982, persisted for another year, and then declined. Radiation emissions, as modeled mathematically, did not account for the observed increase. Interpretation in terms of accident stress is limited by the lack of an individual measure of stress and by uncertainty about whether stress has a biological effect on cancer in humans. An alternative mechanism for the cancer increase near the plant is through changes in care-seeking and diagnostic practice arising from postaccident concern.

Characterization of the Space Shuttle Ascent Debris using CFD Methods

NASA Technical Reports Server (NTRS)

Murman, Scott M.; Aftosmis, Michael J.; Rogers, Stuart E.

2005-01-01

After video analysis of space shuttle flight STS-107's ascent showed that an object shed from the bipod-ramp region impacted the left wing, a transport analysis was initiated to determine a credible flight path and impact velocity for the piece of debris. This debris transport analysis was performed both during orbit, and after the subsequent re-entry accident. The analysis provided an accurate prediction of the velocity a large piece of foam bipod ramp would have as it impacted the wing leading edge. This prediction was corroborated by video analysis and fully-coupled CFD/six degree of freedom (DOF) simulations. While the prediction of impact velocity was accurate enough to predict critical damage in this case, one of the recommendations of the Columbia Accident Investigation Board (CAIB) for return-to-flight (RTF) was to analyze the complete debris environment experienced by the shuttle stack on ascent. This includes categorizing all possible debris sources, their probable geometric and aerodynamic characteristics, and their potential for damage. This paper is chiefly concerned with predicting the aerodynamic characteristics of a variety of potential debris sources (insulating foam and cork, nose-cone ablator, ice, ...) for the shuttle ascent configuration using CFD methods. These aerodynamic characteristics are used in the debris transport analysis to predict flight path, impact velocity and angle, and provide statistical variation to perform risk analyses where appropriate. The debris aerodynamic characteristics are difficult to determine using traditional methods, such as static or dynamic test data, due to the scaling requirements of simulating a typical debris event. The use of CFD methods has been a critical element for building confidence in the accuracy of the debris transport code by bridging the gap between existing aerodynamic data and the dynamics of full-scale, in-flight events.

AWE: Aviation Weather Data Visualization Environment

NASA Technical Reports Server (NTRS)

Spirkovska, Lilly; Lodha, Suresh K.; Norvig, Peter (Technical Monitor)

2000-01-01

Weather is one of the major causes of aviation accidents. General aviation (GA) flights account for 92% of all the aviation accidents, In spite of all the official and unofficial sources of weather visualization tools available to pilots, there is an urgent need for visualizing several weather related data tailored for general aviation pilots. Our system, Aviation Weather Data Visualization Environment AWE), presents graphical displays of meteorological observations, terminal area forecasts, and winds aloft forecasts onto a cartographic grid specific to the pilot's area of interest. Decisions regarding the graphical display and design are made based on careful consideration of user needs. Integral visual display of these elements of weather reports is designed for the use of GA pilots as a weather briefing and route selection tool. AWE provides linking of the weather information to the flight's path and schedule. The pilot can interact with the system to obtain aviation-specific weather for the entire area or for his specific route to explore what-if scenarios and make "go/no-go" decisions. The system, as evaluated by some pilots at NASA Ames Research Center, was found to be useful.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrews, Nathan; Faucett, Christopher; Haskin, Troy Christopher

Following the conclusion of the first phase of the crosswalk analysis, one of the key unanswered questions was whether or not the deviations found would persist during a partially recovered accident scenario, similar to the one that occurred in TMI - 2. In particular this analysis aims to compare the impact of core degradation morphology on quenching models inherent within the two codes and the coolability of debris during partially recovered accidents. A primary motivation for this study is the development of insights into how uncertainties in core damage progression models impact the ability to assess the potential for recoverymore » of a degraded core. These quench and core recovery models are of the most interest when there is a significant amount of core damage, but intact and degraded fuel still remain in the cor e region or the lower plenum. Accordingly this analysis presents a spectrum of partially recovered accident scenarios by varying both water injection timing and rate to highlight the impact of core degradation phenomena on recovered accident scenarios. This analysis uses the newly released MELCOR 2.2 rev. 966 5 and MAAP5, Version 5.04. These code versions, which incorporate a significant number of modifications that have been driven by analyses and forensic evidence obtained from the Fukushima - Daiichi reactor site.« less

Radiation Doses and Associated Risk From the Fukushima Nuclear Accident.

PubMed

Ishikawa, Tetsuo

2017-03-01

The magnitude of dose due to the Fukushima Daiichi Accident was estimated by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2013 report published in April 2014. Following this, the UNSCEAR white paper, which comprises a digest of new information for the 2013 Fukushima report, was published in October 2015. Another comprehensive report on radiation dose due to the accident is the International Atomic Energy Agency (IAEA) report on the Fukushima Daiichi Accident published in August 2015. Although the UNSCEAR and IAEA publications well summarize doses received by residents, they review only literature published before the end of December 2014 and the end of March 2015, respectively. However, some studies on dose estimation have been published since then. In addition, the UNSCEAR 2013 report states it was likely that some overestimation had been introduced generally by the methodology used by the Committee. For example, effects of decontamination were not considered in the lifetime external dose estimated. Decontamination is in progress for most living areas in Fukushima Prefecture, which could reduce long-term external dose to residents. This article mainly reviews recent English language articles that may add new information to the UNSCEAR and IAEA publications. Generally, recent articles suggest lower doses than those presented by the UNSCEAR 2013 report.

Autonomous Control Modes and Optimized Path Guidance for Shipboard Landing in High Sea States

DTIC Science & Technology

2017-04-15

50 0 50 Singular Values Frequency (rad/s) S in g u la r V a lu e s ( d B ) controller . The non -output variables can be estimated by reliable linear...Contract # N00014-14-C-0004 Autonomous Control Modes and Optimized Path Guidance for Shipboard Landing in High Sea States Progress Report...recovery of a VTOL UAV. There is a clear need for additional levels of stability and control augmentation and, ultimately, fully autonomous landing

Prediction of trauma-specific death rates of pedestrians of Fars Province, Iran.

PubMed

Akbari, Maryam; Tabrizi, Reza; Heydari, Seyed Taghi; Sekhavati, Eghbal; Moosazadeh, Mahmood; Lankarani, Kamran Bagheri

2015-09-01

Pedestrians are the most vulnerable group to accidents among road users. Due to the well-known concerns and complications of accidents involving pedestrians, the aim of this study was to identify the rate of such accidents for five-year period. We analyzed all fatalities among pedestrians caused by traffic accidents during years of 2009-2013 in Fars Province in Iran. The study was a cross-sectional study in which logistic regression analysis was used to predict the death rate among pedestrians. Sensitivity analysis using the Monte Carlo method was used to increase the accuracy of the results. Then, we predicted the death rates for the years 2014-2018 predicted and compared the results with the actual data from the previous five-year period (2009-2013). During 2009-2013, 1723 out of 8689 (20.3%) of the people killed in traffic accidents were pedestrians. The death rate for male pedestrians in 2011 was estimated to be 10.86 per 100,000 (with an uncertainty interval of 95% giving a range of 9.85-12.05 per 100,000). Compared to the data for 2006, this represented a decrease of 20% (with a mean decrease of 4% per year). Based on these data, the death date in 2018n was projected to be 8.08 per 100,000 (with an uncertainty interval of 95% giving a range of 7.26-8.87). Similar data and analysis for women indicated that the reduction in the rate of fatalities has been smaller than that for men in recent years, i.e., 2.2% versus 4%. Although great progress has been made in reducing traffic accidents, to date, the death rate is still high among pedestrians. It is essential to continue to find ways to reduce traffic accidents and the pedestrians' deaths associated with them, especially among the elderly, who make up a disproportionate fraction of the deaths.

Prediction of trauma-specific death rates of pedestrians of Fars Province, Iran

PubMed Central

Akbari, Maryam; Tabrizi, Reza; Heydari, Seyed Taghi; Sekhavati, Eghbal; Moosazadeh, Mahmood; Lankarani, Kamran Bagheri

2015-01-01

Introduction: Pedestrians are the most vulnerable group to accidents among road users. Due to the well-known concerns and complications of accidents involving pedestrians, the aim of this study was to identify the rate of such accidents for five-year period. Methods: We analyzed all fatalities among pedestrians caused by traffic accidents during years of 2009–2013 in Fars Province in Iran. The study was a cross-sectional study in which logistic regression analysis was used to predict the death rate among pedestrians. Sensitivity analysis using the Monte Carlo method was used to increase the accuracy of the results. Then, we predicted the death rates for the years 2014–2018 predicted and compared the results with the actual data from the previous five-year period (2009–2013). Results: During 2009–2013, 1723 out of 8689 (20.3%) of the people killed in traffic accidents were pedestrians. The death rate for male pedestrians in 2011 was estimated to be 10.86 per 100,000 (with an uncertainty interval of 95% giving a range of 9.85–12.05 per 100,000). Compared to the data for 2006, this represented a decrease of 20% (with a mean decrease of 4% per year). Based on these data, the death date in 2018n was projected to be 8.08 per 100,000 (with an uncertainty interval of 95% giving a range of 7.26–8.87). Similar data and analysis for women indicated that the reduction in the rate of fatalities has been smaller than that for men in recent years, i.e., 2.2% versus 4%. Conclusion: Although great progress has been made in reducing traffic accidents, to date, the death rate is still high among pedestrians. It is essential to continue to find ways to reduce traffic accidents and the pedestrians’ deaths associated with them, especially among the elderly, who make up a disproportionate fraction of the deaths. PMID:26435824

Safety in New Zealand's adventure tourism industry: the client accident experience of adventure tourism operators.

PubMed

Bentley , T A; Page, S J; Laird, I S

2000-01-01

Injuries and fatalities among participants of adventure tourism activities have the potential to seriously impact on New Zealand's tourism industry. However, the absence of statistics for tourist accidents in New Zealand, and the lack of detailed academic research into adventure tourism safety, means the extent of the problem is unknown. The aims of the present study were to determine the incidence of client injuries across a range of adventure tourism activity sectors, and to identify common accident events and contributory risk factors. A postal questionnaire survey of New Zealand adventure tourism operators was used. Operators were asked to provide information related to their business; the number of recorded client injuries during the preceding 12 month period, January to December 1998; common accident and injury events associated with their activity; and perceived risk factors for accidents in their sector of the adventure tourism industry. The survey was responded to by 142 New Zealand adventure tourism operators. The operators' reported client injury experience suggests the incidence of serious client injuries is very low. Highest client injury incidence rates were found for activities that involved the risk of falling from a moving vehicle or animal (e.g., cycle tours, quad biking, horse riding, and white-water rafting). Slips, trips, and falls on the level were common accident events across most sectors of the industry. Perceived accident/incident causes were most commonly related to the client, and in particular, failure to attend to and follow instructions. The prevalence of client injuries in activity sectors not presently covered by government regulation, suggests policy makers should look again at extending codes of practice to a wider range of adventure tourism activities. Further research considering adventure tourism involvement in overseas visitor hospitalized injuries in New Zealand, is currently in progress. This will provide supporting evidence for the risk associated with participation in a range of commercial and independently undertaken adventure activities.

Re-evaluation of P-T paths across the Himalayan Main Central Thrust

NASA Astrophysics Data System (ADS)

Catlos, E. J.; Harrison, M.; Kelly, E. D.; Ashley, K.; Lovera, O. M.; Etzel, T.; Lizzadro-McPherson, D. J.

2016-12-01

The Main Central Thrust (MCT) is the dominant crustal thickening structure in the Himalayas, juxtaposing high-grade Greater Himalayan Crystalline rocks over the lower-grade Lesser Himalaya Formations. The fault is underlain by a 2 to 12-km-thick sequence of deformed rocks characterized by an apparent inverted metamorphic gradient, termed the MCT shear zone. Garnet-bearing rocks sampled from across the MCT along the Marysandi River in central Nepal contain monazite that decrease in age from Early Miocene (ca. 20 Ma) in the hanging wall to Late Miocene-Pliocene (ca. 7 Ma and 3 Ma) towards structurally lower levels in the shear zone. We obtained high-resolution garnet-zoning pressure-temperature (P-T) paths from 11 of the same rocks used for monazite geochronology using a recently-developed semi-automated Gibbs-free-energy-minimization technique. Quartz-in-garnet Raman barometry refined the locations of the paths. Diffusional re-equilibration of garnet zoning in hanging wall samples prevented accurate path determinations from most Greater Himalayan Crystalline samples, but one that shows a bell-shaped Mn zoning profile shows a slight decrease in P (from 8.2 to 7.6kbar) with increase in T (from 590 to 640ºC). Three MCT shear zone samples were modeled: one yields a simple path increasing in both P and T (6 to 7kbar, 540 to 580ºC); the others yield N-shaped paths that occupy similar P-T space (4 to 5.5 kbar, 500 to 560ºC). Five lower lesser Himalaya garnet-bearing rocks were modeled. One yields a path increasing in both P-T (6 to 7 kbar, 525 to 550ºC) but others show either sharp compression/decompression or N-shape paths (within 4.5-6 kbar and 530-580ºC). The lowermost sample decreases in P (5.5 to 5 kbar) over increasing T (540 to 580°C). No progressive change is seen from one type of path to another within the Lesser Himalayan Formations to the MCT zone. The results using the modeling approach yield lower P-T conditions compared to the Gibbs method and lower core/rim P-T conditions compared to traditional thermometers and barometers. Inclusion barometry suggests that baric estimates from the modeling may be underestimated by 2-4 kbar. Despite uncertainty, path shapes are consistent with a model in which the MCT shear zone experienced a progressive accretion of footwall slivers.

Probe for optically monitoring progress of in-situ vitrification of soil

DOEpatents

Timmerman, Craig L.; Oma, Kenton H.; Davis, Karl C.

1988-01-01

A detector system for sensing the progress of an ISV process along an expected path comprises multiple sensors each having an input port. The input ports are distributed along the expected path of the ISV process between a starting location and an expected ending location. Each sensor generates an electrical signal representative of the temperature in the vicinity of its input port. A signal processor is coupled to the sensors to receive an electrical signal generated by a sensor, and generate a signal which is encoded with information which identifies the sensor and whether the ISV process has reached the sensor's input port. A transmitter propagates the encoded signal. The signal processor and the transmitter are below ground at a location beyond the expected ending location of the ISV process in the direction from the starting location to the expected ending location. A signal receiver and a decoder are located above ground for receiving the encoded signal propagated by the transmitter, decoding the encoded signal and providing a human-perceptible indication of the progress of the ISV process.

Probe for optically monitoring progress of in-situ vitrification of soil

DOEpatents

Timmerman, C.L.; Oma, K.H.; Davis, K.C.

1988-08-09

A detector system for sensing the progress of an ISV process along an expected path comprises multiple sensors each having an input port. The input ports are distributed along the expected path of the ISV process between a starting location and an expected ending location. Each sensor generates an electrical signal representative of the temperature in the vicinity of its input port. A signal processor is coupled to the sensors to receive an electrical signal generated by a sensor, and generate a signal which is encoded with information which identifies the sensor and whether the ISV process has reached the sensor's input port. A transmitter propagates the encoded signal. The signal processor and the transmitter are below ground at a location beyond the expected ending location of the ISV process in the direction from the starting location to the expected ending location. A signal receiver and a decoder are located above ground for receiving the encoded signal propagated by the transmitter, decoding the encoded signal and providing a human-perceptible indication of the progress of the ISV process. 7 figs.

Congenitally blind individuals rapidly adapt to coriolis force perturbations of their reaching movements

NASA Technical Reports Server (NTRS)

DiZio, P.; Lackner, J. R.

2000-01-01

Reaching movements made to visual targets in a rotating room are initially deviated in path and endpoint in the direction of transient Coriolis forces generated by the motion of the arm relative to the rotating environment. With additional reaches, movements become progressively straighter and more accurate. Such adaptation can occur even in the absence of visual feedback about movement progression or terminus. Here we examined whether congenitally blind and sighted subjects without visual feedback would demonstrate adaptation to Coriolis forces when they pointed to a haptically specified target location. Subjects were tested pre-, per-, and postrotation at 10 rpm counterclockwise. Reaching to straight ahead targets prerotation, both groups exhibited slightly curved paths. Per-rotation, both groups showed large initial deviations of movement path and curvature but within 12 reaches on average had returned to prerotation curvature levels and endpoints. Postrotation, both groups showed mirror image patterns of curvature and endpoint to the per-rotation pattern. The groups did not differ significantly on any of the performance measures. These results provide compelling evidence that motor adaptation to Coriolis perturbations can be achieved on the basis of proprioceptive, somatosensory, and motor information in the complete absence of visual experience.

Severe tracheal stenosis with tracheopathia osteoplastica-like changes due to traumatic blunt injury.

PubMed

Kakinuma, Kazutaka; Morikawa, Kei; Miyamoto, Yasuhiro; Saji, Hisashi; Mineshita, Masamichi; Miyazawa, Teruomi

2014-12-01

A 17-year-old man was injured in a motorcycle accident, leading to a complex cerebral contusion and hepatic injury. Approximately one month after being discharged from the hospital, the patient experienced gradually progressive dyspnea on exertion. Chest computed tomography revealed severe upper tracheal stenosis; thus, emergency tracheotomy and subsequent tracheoplasty were performed. Microscopically, the deformation of tracheal cartilage and extensive interstitial ossification/fibro-elastic changes were observed. To our knowledge, this is the first report documenting the ossification of the trachea that rapidly progressed after injury, which was confirmed by surgical resection of the upper trachea.

A Numerical Model of Exchange Chromatography Through 3D Lattice Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salloum, Maher; Robinson, David B.

Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3D printers. It contains an array of regular three-dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of one-dimensional flow paths that resemble more traditional honeycombmore » monoliths. A reaction front moves through the columns and then elutes. Here, the front is sharper at all flow rates for the structure with three-dimensional flow paths, and this structure is more robust to channel width defects than the one-dimensional array.« less

A Numerical Model of Exchange Chromatography Through 3D Lattice Structures

DOE PAGES

Salloum, Maher; Robinson, David B.

2018-01-30

Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3D printers. It contains an array of regular three-dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of one-dimensional flow paths that resemble more traditional honeycombmore » monoliths. A reaction front moves through the columns and then elutes. Here, the front is sharper at all flow rates for the structure with three-dimensional flow paths, and this structure is more robust to channel width defects than the one-dimensional array.« less

NASA Space Launch System (SLS) Progress Report

NASA Technical Reports Server (NTRS)

Williams, Tom

2012-01-01

The briefing objectives are: (1) Explain the SLS current baseline architecture and the SLS block-upgrade approach. (2) Summarize the SLS evolutionary path in relation to the Advanced Booster and Advanced Development NASA Research Announcements.

LMFBR fuel assembly design for HCDA fuel dispersal

DOEpatents

Lacko, Robert E.; Tilbrook, Roger W.

1984-01-01

A fuel assembly for a liquid metal fast breeder reactor having an upper axial blanket region disposed in a plurality of zones within the fuel assembly. The characterization of a zone is dependent on the height of the axial blanket region with respect to the active fuel region. The net effect of having a plurality of zones is to establish a dispersal flow path for the molten materials resulting during a core meltdown accident. Upward flowing molten material can escape from the core region and/or fuel assembly without solidifying on the surface of fuel rods due to the heat sink represented by blanket region pellets.

Study on the Transient Process of 500kV Substations Secondary Equipment

NASA Astrophysics Data System (ADS)

Li, Hongbo; Li, Pei; Zhang, Yanyan; Niu, Lin; Gao, Nannan; Si, Tailong; Guo, Jiadong; Xu, Min-min; Li, Guofeng; Guo, Liangfeng

2017-05-01

By analyzing on the reason of the lightning accident occur in the substation, the way of lightning incoming surge invading the secondary system is summarized. The interference source acts on the secondary system through various coupling paths. It mainly consists of four ways: the conductance coupling mode, the Capacitive Coupling Mode, the inductive coupling mode, The Radiation Interference Model. Then simulated the way with the program-ATP. At last, from the three aspects of low-voltage power supply system, the impact potential distribution of grounding grid, the secondary system and the computer system. The lightning protection measures is put forward.

Reconstruction for proton computed tomography by tracing proton trajectories: A Monte Carlo study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Tianfang; Liang Zhengrong; Singanallur, Jayalakshmi V.

Proton computed tomography (pCT) has been explored in the past decades because of its unique imaging characteristics, low radiation dose, and its possible use for treatment planning and on-line target localization in proton therapy. However, reconstruction of pCT images is challenging because the proton path within the object to be imaged is statistically affected by multiple Coulomb scattering. In this paper, we employ GEANT4-based Monte Carlo simulations of the two-dimensional pCT reconstruction of an elliptical phantom to investigate the possible use of the algebraic reconstruction technique (ART) with three different path-estimation methods for pCT reconstruction. The first method assumes amore » straight-line path (SLP) connecting the proton entry and exit positions, the second method adapts the most-likely path (MLP) theoretically determined for a uniform medium, and the third method employs a cubic spline path (CSP). The ART reconstructions showed progressive improvement of spatial resolution when going from the SLP [2 line pairs (lp) cm{sup -1}] to the curved CSP and MLP path estimates (5 lp cm{sup -1}). The MLP-based ART algorithm had the fastest convergence and smallest residual error of all three estimates. This work demonstrates the advantage of tracking curved proton paths in conjunction with the ART algorithm and curved path estimates.« less

Investigation of Containment Flooding Strategy for Mark-III Nuclear Power Plant with MAAP4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su Weinian; Wang, S.-J.; Chiang, S.-C

2005-06-15

Containment flooding is an important strategy for severe accident management of a conventional boiling water reactor (BWR) system. The purpose of this work is to investigate the containment flooding strategy of the Mark-III system after a reactor pressure vessel (RPV) breach. The Kuosheng Power Plant is a typical BWR-6 nuclear power plant (NPP) with Mark-III containment. The Severe Accident Management Guideline (SAMG) of the Kuosheng NPP has been developed based on the BWR Owners Group (BWROG) Emergency Procedure and Severe Accident Guidelines, Rev. 2. Therefore, the Kuosheng NPP is selected as the plant for study, and the MAAP4 code ismore » chosen as the tool for analysis. A postulated specific station blackout sequence for the Kuosheng NPP is cited as a reference case for this analysis. Because of the design features of Mark-III containment, the debris in the reactor cavity may not be submerged after an RPV breach when one follows the containment flooding strategy as suggested in the BWROG generic guideline, and the containment integrity could be challenged eventually. A more specific containment flooding strategy with drywell venting after an RPV breach is investigated, and a more stable plant condition is achieved with this strategy. Accordingly, the containment flooding strategy after an RPV breach will be modified for the Kuosheng SAMG, and these results are applicable to typical Mark-III plants with drywell vent path.« less

Behavior analysis, mentalism, and the path to social justice

PubMed Central

Moore, J.

2003-01-01

Traditional psychology is mentalistic in the sense that it appeals to inner causes in the explanation of behavior. Two examples of mentalism in traditional psychology are (a) dispositional attributions and (b) conventional treatments of intelligence. These examples may be linked to such pernicious social -isms as racism and sexism by noting that some individuals justify engaging in discriminatory conduct toward others by appealing to some deficient inner quality of those being discriminated against. This sort of mentalistic appeal ultimately prevents some members of our society from being integrated into society and from progressing down the path of social justice. Behavior analysis offers a constructional alternative to the mentalistic views of traditional psychology and allows our society as a whole to move down the path. PMID:22478401

Progress Is No Accident: Why ESEA Can't Backtrack on High School Graduation Rates

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2015

2015-01-01

In conjunction with the White House Next Gen High School Summit on November 10, a new report finds that the number of high school dropouts decreased from 1 million in 2008 to approximately 750,000 in 2012. The report, released by the Alliance for Excellent Education, America's Promise Alliance, Civic Enterprises, and Everyone Graduates Center,…

Altitude valve for railway suspension control system

NASA Astrophysics Data System (ADS)

Zhang, Xuan; Zhang, Lihao; Li, Qingxuan; Chen, WanSong

2017-09-01

With the variation of people and material during vehicle service, the gravity of vehicle could be unbalanced. As a result it might cause accident. In order to solve this problem, altitude valve is assembled on board. It can adjust the gravity of vehicle by the intake and outlet progress of the spring in the altitude valve to prevent the tilt of vehicles.

Towards Community Employment: A Comprehensive Data-Based Training System for Mentally Retarded Adults.

ERIC Educational Resources Information Center

Dardig, Jill C.; Jewett, Robert J.

1979-01-01

The article describes the efforts of Project PATH (Progressive Approach to Training and Habilitation) to design a comprehensive training program for moderately and severely retarded adults in a sheltered workshop setting. (SBH)

KENNEDY SPACE CENTER, FLA. - Suzy Cunningham sings the national anthem to kick off Center Director Jim Kennedy’s first all-hands meeting conducted for employees. She is senior spaceport manager, NASA/Air Force Spaceport Planning and Customer Service Office. Making presentations were Dr. Woodrow Whitlow Jr., KSC deputy director; Tim Wilson, assistant chief engineer for Shuttle; and Bill Pickavance, vice president and deputy program manager, Florida operations, United Space Alliance. Representatives from the Shuttle program and contractor team were on hand to discuss the Columbia Accident Investigation Board report and where KSC stands in its progress toward return to flight.

NASA Image and Video Library

2003-09-17

KENNEDY SPACE CENTER, FLA. - Suzy Cunningham sings the national anthem to kick off Center Director Jim Kennedy’s first all-hands meeting conducted for employees. She is senior spaceport manager, NASA/Air Force Spaceport Planning and Customer Service Office. Making presentations were Dr. Woodrow Whitlow Jr., KSC deputy director; Tim Wilson, assistant chief engineer for Shuttle; and Bill Pickavance, vice president and deputy program manager, Florida operations, United Space Alliance. Representatives from the Shuttle program and contractor team were on hand to discuss the Columbia Accident Investigation Board report and where KSC stands in its progress toward return to flight.

[Prognosis in pediatric traumatic brain injury. A dynamic cohort study].

PubMed

Vázquez-Solís, María G; Villa-Manzano, Alberto I; Sánchez-Mosco, Dalia I; Vargas-Lares, José de Jesús; Plascencia-Fernández, Irma

2013-01-01

traumatic brain injury is a main cause of hospital admission and death in children. Our objective was to identify prognostic factors of pediatric traumatic brain injury. this was a dynamic cohort study of traumatic brain injury with 6 months follow-up. The exposition was: mild or moderate/severe traumatic brain injury, searching for prognosis (morbidity-mortality and decreased Glasgow scale). Relative risk and logistic regression was estimated for prognostic factors. we evaluated 440 patients with mild traumatic brain injury and 98 with moderate/severe traumatic brain injury. Morbidity for mild traumatic brain injury was 1 %; for moderate/severe traumatic brain injury, 5 %. There were no deaths. Prognostic factors for moderate/severe traumatic brain injury were associated injuries (RR = 133), fractures (RR = 60), street accidents (RR = 17), night time accidents (RR = 2.3) and weekend accidents (RR = 2). Decreased Glasgow scale was found in 9 %, having as prognostic factors: visible injuries (RR = 3), grown-up supervision (RR = 2.5) and time of progress (RR = 1.6). there should be a prognosis established based on kinetic energy of the injury and not only with Glasgow Scale.

Monitoring of the degradation in the rat's articular cartilage inducing osteoarthritis using common-path Fourier-domain optical coherence tomography

NASA Astrophysics Data System (ADS)

Shin, D. H.; Park, S. H.; Kim, B. Y.; Lee, M. Y.; Baik, H. K.; Seo, J. H.; Kang, J. U.; Song, C. G.

2013-03-01

The objective of this experiment is to evaluate the utility and limitations of optical coherence tomography (OCT) for real-time, high-resolution structural analysis. We monitored the degradation of the rat's articular cartilage inducing osteoarthritis (OA) and the change of the rat's articular cartilage recovery by treatment medication, using our developed common-path Fourier-domain (CP-FD) OCT. Also, we have done a comparative analysis the rat's articular cartilage and OA grade. To observe the progression of OA, we induced OA by injecting the monosodium iodoacetate (MIA) into the right knee joint. After the injection of MIA, we sacrificed the rats at intervals of 3 days and obtained OCT and histological images. OCT and histological images showed the OA progress of similar pattern. These results illustrated the potential for non-invasive diagnosis about the grade of OA using CP-FD OCT.

Modeling Progressive Damage Using Local Displacement Discontinuities Within the FEAMAC Multiscale Modeling Framework

NASA Technical Reports Server (NTRS)

Ranatunga, Vipul; Bednarcyk, Brett A.; Arnold, Steven M.

2010-01-01

A method for performing progressive damage modeling in composite materials and structures based on continuum level interfacial displacement discontinuities is presented. The proposed method enables the exponential evolution of the interfacial compliance, resulting in unloading of the tractions at the interface after delamination or failure occurs. In this paper, the proposed continuum displacement discontinuity model has been used to simulate failure within both isotropic and orthotropic materials efficiently and to explore the possibility of predicting the crack path, therein. Simulation results obtained from Mode-I and Mode-II fracture compare the proposed approach with the cohesive element approach and Virtual Crack Closure Techniques (VCCT) available within the ABAQUS (ABAQUS, Inc.) finite element software. Furthermore, an eccentrically loaded 3-point bend test has been simulated with the displacement discontinuity model, and the resulting crack path prediction has been compared with a prediction based on the extended finite element model (XFEM) approach.

Towards a Drug Development Path that Targets Metastatic Progression in Osteosarcoma

PubMed Central

Khanna, Chand; Fan, Timothy M.; Gorlick, Richard; Helman, Lee J; Kleinerman, Eugenie S.; Adamson, Peter C.; Houghton, Peter J.; Tap, William D.; Welch, Danny R.; Steeg, Patricia S.; Merlino, Glenn; Sorensen, Poul HB; Kirsch, David G.; Janeway, Katherine A.; Weigel, Brenda; Randall, R. Lor; Meltzer, Paul; Withrow, Stephen J; Paoloni, Melissa; Kaplan, Rosandra N.; Teicher, Beverly A.; Seibel, Nita L.; Üren, Aykut; Patel, Shreyaskumar R.; Trent, Jeffrey; Savage, Sharon A.; Mirabello, Lisa; Reinke, Denise; Barkauskas, Donald A.; Krailo, Mark; Smith, Malcolm A.; Bernstein, Mark

2014-01-01

Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in osteosarcoma patients. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for osteosarcoma patients in over 30 years. Based on our growing understanding of metastasis biology, it is now reasonable and essential that we focus on developing therapeutics that target metastatic progression. To advance this agenda a meeting of key opinion leaders and experts in the metastasis and osteosarcoma communities was convened in Bethesda Maryland. The goal of this meeting was to provide a “Perspective” that would establish a preclinical translational path that could support the early evaluation of potential therapeutic agents that uniquely target the metastatic phenotype. Although focused on osteosarcoma the need for this perspective is shared among many cancer types. The consensus achieved from the meeting included the following: That the biology of metastatic progression is associated with metastasis-specific targets/processes that may not influence grossly detectable lesions; targeting of metastasis-specific processes is feasible; rigorous preclinical data is needed to support translation of metastasis-specific agents into human trials where regression of measurable disease is not an expected outcome; preclinical data should include an understanding of mechanism of action, validation of pharmacodynamic markers of effective exposure and response, the use of several murine models of effectiveness, and where feasible the inclusion of the dog with naturally occurring osteosarcoma to define the activity of new drugs in the micro-metastatic disease setting. PMID:24803583

Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson’s Disease 1

PubMed Central

Stephenson, Diane; Hu, Michele T.; Romero, Klaus; Breen, Kieran; Burn, David; Ben-Shlomo, Yoav; Bhattaram, Atul; Isaac, Maria; Venuto, Charles; Kubota, Ken; Little, Max A.; Friend, Stephen; Lovestone, Simon; Morris, Huw R.; Grosset, Donald; Sutherland, Margaret; Gallacher, John; Williams-Gray, Caroline; Bain, Lisa J.; Avilés, Enrique; Marek, Ken; Toga, Arthur W.; Stark, Yafit; Forrest Gordon, Mark; Ford, Steve

2015-01-01

Abstract Parkinson’s disease is a complex heterogeneous disorder with urgent need for disease-modifying therapies. Progress in successful therapeutic approaches for PD will require an unprecedented level of collaboration. At a workshop hosted by Parkinson’s UK and co-organized by Critical Path Institute’s (C-Path) Coalition Against Major Diseases (CAMD) Consortiums, investigators from industry, academia, government and regulatory agencies agreed on the need for sharing of data to enable future success. Government agencies included EMA, FDA, NINDS/NIH and IMI (Innovative Medicines Initiative). Emerging discoveries in new biomarkers and genetic endophenotypes are contributing to our understanding of the underlying pathophysiology of PD. In parallel there is growing recognition that early intervention will be key for successful treatments aimed at disease modification. At present, there is a lack of a comprehensive understanding of disease progression and the many factors that contribute to disease progression heterogeneity. Novel therapeutic targets and trial designs that incorporate existing and new biomarkers to evaluate drug effects independently and in combination are required. The integration of robust clinical data sets is viewed as a powerful approach to hasten medical discovery and therapies, as is being realized across diverse disease conditions employing big data analytics for healthcare. The application of lessons learned from parallel efforts is critical to identify barriers and enable a viable path forward. A roadmap is presented for a regulatory, academic, industry and advocacy driven integrated initiative that aims to facilitate and streamline new drug trials and registrations in Parkinson’s disease. PMID:26406139

Technical Development Path for Gas Foil Bearings

NASA Technical Reports Server (NTRS)

Dellacorte, Christopher

2016-01-01

Foil gas bearings are in widespread commercial use in air cycle machines, turbocompressors and microturbine generators and are emerging in more challenging applications such as turbochargers, auxiliary power units and propulsion gas turbines. Though not well known, foil bearing technology is well over fifty years old. Recent technological developments indicate that their full potential has yet to be realized. This paper investigates the key technological developments that have characterized foil bearing advances. It is expected that a better understanding of foil gas bearing development path will aid in future development and progress towards more advanced applications.

A study of methods to predict and measure the transmission of sound through the walls of light aircraft

NASA Technical Reports Server (NTRS)

Bernhard, R. J.; Bolton, J. S.; Gardner, B.; Mickol, J.; Mollo, C.; Bruer, C.

1986-01-01

Progress was made in the following areas: development of a numerical/empirical noise source identification procedure using bondary element techniques; identification of structure-borne noise paths using structural intensity and finite element methods; development of a design optimization numerical procedure to be used to study active noise control in three-dimensional geometries; measurement of dynamic properties of acoustical foams and incorporation of these properties in models governing three-dimensional wave propagation in foams; and structure-borne sound path identification by use of the Wigner distribution.

Wheelchair Navigation System for Disabled and Elderly People

PubMed Central

Kim, Eun Yi

2016-01-01

An intelligent wheelchair (IW) system is developed in order to support safe mobility for disabled or elderly people with various impairments. The proposed IW offers two main functions: obstacle detection and avoidance, and situation recognition. First, through a combination of a vision sensor and eight ultrasonic ones, it detects diverse obstacles and produces occupancy grid maps (OGMs) that describe environmental information, including the positions and sizes of obstacles, which is then given to the learning-based algorithm. By learning the common patterns among OGMs assigned to the same directions, the IW can automatically find paths to prevent collisions with obstacles. Second, it distinguishes a situation whereby the user is standing on a sidewalk, traffic intersection, or roadway through analyzing the texture and shape of the images, which aids in preventing any accidents that would result in fatal injuries to the user, such as collisions with vehicles. From the experiments that were performed in various environments, we can prove the following: (1) the proposed system can recognize different types of outdoor places with 98.3% accuracy; and (2) it can produce paths that avoid obstacles with 92.0% accuracy. PMID:27801852

Second-Guessing Scientists and Engineers: Post Hoc Criticism and the Reform of Practice in Green Chemistry and Engineering.

PubMed

Lynch, William T

2015-10-01

The article examines and extends work bringing together engineering ethics and Science and Technology Studies, which had built upon Diane Vaughan's analysis of the Challenger shuttle accident as a test case. Reconsidering the use of her term "normalization of deviance," the article argues for a middle path between moralizing against and excusing away engineering practices contributing to engineering disaster. To explore an illustrative pedagogical case and to suggest avenues for constructive research developing this middle path, it examines the emergence of green chemistry and green engineering. Green chemistry began when Paul Anastas and John Warner developed a set of new rules for chemical synthesis that sought to learn from missed opportunities to avoid environmental damage in the twentieth century, an approach that was soon extended to engineering as well. Examination of tacit assumptions about historical counterfactuals in recent, interdisciplinary discussions of green chemistry illuminate competing views about the field's prospects. An integrated perspective is sought, addressing how both technical practice within chemistry and engineering and the influence of a wider "social movement" can play a role in remedying environmental problems.

IDAHO NATIONAL LABORATORY TRANSPORTATION TASK REPORT ON ACHIEVING MODERATOR EXCLUSION AND SUPPORTING STANDARDIZED TRANSPORTATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

D.K. Morton

2011-09-01

Following the defunding of the Yucca Mountain Project, it is reasonable to assume that commercial used fuel will remain in storage for the foreseeable future. This report proposes supplementing the ongoing research and development work related to potential degradation of used fuel, baskets, poisons, and storage canisters during an extended period of storage with a parallel path. This parallel path can assure criticality safety during transportation by implementing a concept that achieves moderator exclusion (no in-leakage of moderator into the used fuel cavity). Using updated risk assessment insights for additional technical justification and relying upon a component inside of themore » transportation cask that provides a watertight function, a strong argument can be made that moderator intrusion is not credible and should not be a required assumption for criticality evaluations during normal conditions of transportation. A demonstrating testing program supporting a detailed analytical effort as well as updated risk assessment insights can provide the basis for moderator exclusion during hypothetical accident conditions. This report also discusses how this engineered concept can support the goal of standardized transportation.« less

An unusual occupational accident: fall into a sewage plant tank with lethal outcome.

PubMed

Padosch, Stephan A; Dettmeyer, Reinhard B; Kröner, Lars U; Preuss, Johanna; Madea, Burkhard

2005-04-20

Occupational accidents, often presenting with lethal outcomes, are a rarely reported issue in forensic literature. However, these incidents are part of medicolegal casework with special regard to reconstruction, liabilities and insurance law-related issues, respectively. We report on a lethal occupational accident in a metropolitan sewage plant. When performing routine controls, a technician fell into an overflow sewer and was immediately pulled into a 30 cm diameter drain. Rescue efforts were initiated immediately, but had to be terminated due to gas warning. Rescue teams continued the search, however, the body remained undiscoverable. Forty-eight hours later, the cadaver was found in an adjacent digester tank, from where it was finally rescued. It was concluded, that the body had been transported between the overflow sewer and the digester tank through a 120 m pipeline with several 90 degrees bendings and branch connections with a minimum diameter of 25 cm at the discharge valve. On medicolegal examination, the cadaver showed marked signs of advanced decomposition caused by anaerobic microorganisms in the 37 degrees C biomass environment. Moreover, as a consequence of the passage of the pipeline system, signs of massive trauma (several comminuted and compound fractures) were disclosed at autopsy. To us, this is the first report on a lethal occupational accident in a sewage plant; our observations demonstrate the rapid progress of putrefaction in a warm anaerobic bacterial environment and the massive trauma sustained.

The bi-directional leader observation in positive cloud-to-ground lightning flashes during summer thunderstorm season

NASA Astrophysics Data System (ADS)

Nakamura, Y.; Manabu, A.; Morimoto, T.; Ushio, T.; Kawasaki, Z.; Miki, M.; Shimizu, M.

2009-12-01

In this paper, we present observations of positive cloud-to-ground (+CG) lightning flashes obtained with the VHF BDITF (VHF Broadband Digital InTerFerometer) and the ALPS (Automatic Lightning Discharge Progressing Feature Observation System). The VHF BDITF observed two- (2D) and three-dimensional (3D) developments of lightning flashes with high time resolution. The ALPS observed the luminous propagation of the local process at low altitudes within its observational range. At 2028:59 JST on 8 August, 2008, we observed the 3D spatiotemporal development channels of +CG lightning flash with the VHF BDITF and the RS with the lightning location and protection (LLP) system. This flash is divided before and after the RS. In the former stage, the in-cloud negative breakdown (NB) progress about 15 km horizontally between 6 and 10 km high. The LLP system detects the RS near the initiation point of that negative breakdown (NB) at the end of the former stage. In the latter stage, the new NB runs through the same path as the first NB before the RS. The luminous intensity of the RS near the ground obtained with the ALPS is synchronized with the development of the new NB. The time variation of luminous intensity by the ALPS has two peaks. The time difference of these peaks is corresponding to the blank of the VHF radiation. Since the new NB following the RS runs through the path of the first NB, the positive breakdown (PB), which is not visualized by the VHF BDITF, could be considered to progress from the starting point of the first NB and touches to the ground. The RS current propagates and penetrates in the opposite direction as visualized subsequent NB. This suggests the first NB and the PB progress together. This +CG lightning flash has the bi-directional leader. To assume the path of the PB is straight line, the velocity of the PB is about 4 × 104 m/s.

Cumulative Significance of Hyporheic Exchange and Biogeochemical Processing in River Networks

NASA Astrophysics Data System (ADS)

Harvey, J. W.; Gomez-Velez, J. D.

2014-12-01

Biogeochemical reactions in rivers that decrease excessive loads of nutrients, metals, organic compounds, etc. are enhanced by hydrologic interactions with microbially and geochemically active sediments of the hyporheic zone. The significance of reactions in individual hyporheic flow paths has been shown to be controlled by the contact time between river water and sediment and the intrinsic reaction rate in the sediment. However, little is known about how the cumulative effects of hyporheic processing in large river basins. We used the river network model NEXSS (Gomez-Velez and Harvey, submitted) to simulate hyporheic exchange through synthetic river networks based on the best available models of network topology, hydraulic geometry and scaling of geomorphic features, grain size, hydraulic conductivity, and intrinsic reaction rates of nutrients and metals in river sediment. The dimensionless reaction significance factor, RSF (Harvey et al., 2013) was used to quantify the cumulative removal fraction of a reactive solute by hyporheic processing. SF scales reaction progress in a single pass through the hyporheic zone with the proportion of stream discharge passing through the hyporheic zone for a specified distance. Reaction progress is optimal where the intrinsic reaction timescale in sediment matches the residence time of hyporheic flow and is less efficient in longer residence time hyporheic flow as a result of the decreasing proportion of river flow that is processed by longer residence time hyporheic flow paths. In contrast, higher fluxes through short residence time hyporheic flow paths may be inefficient because of the repeated surface-subsurface exchanges required to complete the reaction. Using NEXSS we found that reaction efficiency may be high in both small streams and large rivers, although for different reasons. In small streams reaction progress generally is dominated by faster pathways of vertical exchange beneath submerged bedforms. Slower exchange beneath meandering river banks mainly has importance only in large rivers. For solutes entering networks in proportion to water inputs it is the lower order streams that tend to dominate cumulative reaction progress.

Time optimized path-choice in the termite hunting ant Megaponera analis.

PubMed

Frank, Erik T; Hönle, Philipp O; Linsenmair, K Eduard

2018-05-10

Trail network systems among ants have received a lot of scientific attention due to their various applications in problem solving of networks. Recent studies have shown that ants select the fastest available path when facing different velocities on different substrates, rather than the shortest distance. The progress of decision-making by these ants is determined by pheromone-based maintenance of paths, which is a collective decision. However, path optimization through individual decision-making remains mostly unexplored. Here we present the first study of time-optimized path selection via individual decision-making by scout ants. Megaponera analis scouts search for termite foraging sites and lead highly organized raid columns to them. The path of the scout determines the path of the column. Through installation of artificial roads around M. analis nests we were able to influence the pathway choice of the raids. After road installation 59% of all recorded raids took place completely or partly on the road, instead of the direct, i.e. distance-optimized, path through grass from the nest to the termites. The raid velocity on the road was more than double the grass velocity, the detour thus saved 34.77±23.01% of the travel time compared to a hypothetical direct path. The pathway choice of the ants was similar to a mathematical model of least time allowing us to hypothesize the underlying mechanisms regulating the behavior. Our results highlight the importance of individual decision-making in the foraging behavior of ants and show a new procedure of pathway optimization. © 2018. Published by The Company of Biologists Ltd.

Light-Water-Reactor safety research program. Quarterly progress report, January--March 1977

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The report summarizes the Argonne National Laboratory work performed during January, February, and March 1977 on water-reactor-safety problems. The following research and development areas are covered: (1) loss-of-coolant accident research: heat transfer and fluid dynamics; (2) transient fuel response and fission-product release program; (3) mechanical properties of zircaloy containing oxygen; and (4) steam-explosion studies.

Effect of a limited-enforcement intelligent tutoring system in dermatopathology on student errors, goals and solution paths.

PubMed

Payne, Velma L; Medvedeva, Olga; Legowski, Elizabeth; Castine, Melissa; Tseytlin, Eugene; Jukic, Drazen; Crowley, Rebecca S

2009-11-01

Determine effects of a limited-enforcement intelligent tutoring system in dermatopathology on student errors, goals and solution paths. Determine if limited enforcement in a medical tutoring system inhibits students from learning the optimal and most efficient solution path. Describe the type of deviations from the optimal solution path that occur during tutoring, and how these deviations change over time. Determine if the size of the problem-space (domain scope), has an effect on learning gains when using a tutor with limited enforcement. Analyzed data mined from 44 pathology residents using SlideTutor-a Medical Intelligent Tutoring System in Dermatopathology that teaches histopathologic diagnosis and reporting skills based on commonly used diagnostic algorithms. Two subdomains were included in the study representing sub-algorithms of different sizes and complexities. Effects of the tutoring system on student errors, goal states and solution paths were determined. Students gradually increase the frequency of steps that match the tutoring system's expectation of expert performance. Frequency of errors gradually declines in all categories of error significance. Student performance frequently differs from the tutor-defined optimal path. However, as students continue to be tutored, they approach the optimal solution path. Performance in both subdomains was similar for both errors and goal differences. However, the rate at which students progress toward the optimal solution path differs between the two domains. Tutoring in superficial perivascular dermatitis, the larger and more complex domain was associated with a slower rate of approximation towards the optimal solution path. Students benefit from a limited-enforcement tutoring system that leverages diagnostic algorithms but does not prevent alternative strategies. Even with limited enforcement, students converge toward the optimal solution path.

Everything You Always Wanted to Know About Maturity Models

DTIC Science & Technology

2014-01-23

path of experience, wisdom, perfection, or acculturation . Depicts an evolutionary progression of an attribute, characteristic, pattern, or...Processes are acculturated , defined, measured, and governed • Defined Level 3 •Managed Level 2 • Performed Level 1 • Incomplete Level 0

Traveling in the dark: the legibility of a regular and predictable structure of the environment extends beyond its borders.

PubMed

Yaski, Osnat; Portugali, Juval; Eilam, David

2012-04-01

The physical structure of the surrounding environment shapes the paths of progression, which in turn reflect the structure of the environment and the way that it shapes behavior. A regular and coherent physical structure results in paths that extend over the entire environment. In contrast, irregular structure results in traveling over a confined sector of the area. In this study, rats were tested in a dark arena in which half the area contained eight objects in a regular grid layout, and the other half contained eight objects in an irregular layout. In subsequent trials, a salient landmark was placed first within the irregular half, and then within the grid. We hypothesized that rats would favor travel in the area with regular order, but found that activity in the area with irregular object layout did not differ from activity in the area with grid layout, even when the irregular half included a salient landmark. Thus, the grid impact in one arena half extended to the other half and overshadowed the presumed impact of the salient landmark. This could be explained by mechanisms that control spatial behavior, such as grid cells and odometry. However, when objects were spaced irregularly over the entire arena, the salient landmark became dominant and the paths converged upon it, especially from objects with direct access to the salient landmark. Altogether, three environmental properties: (i) regular and predictable structure; (ii) salience of landmarks; and (iii) accessibility, hierarchically shape the paths of progression in a dark environment. Copyright © 2012 Elsevier B.V. All rights reserved.

NASA Structural Analysis Report on the American Airlines Flight 587 Accident - Local Analysis of the Right Rear Lug

NASA Technical Reports Server (NTRS)

Raju, Ivatury S; Glaessgen, Edward H.; Mason, Brian H; Krishnamurthy, Thiagarajan; Davila, Carlos G

2005-01-01

A detailed finite element analysis of the right rear lug of the American Airlines Flight 587 - Airbus A300-600R was performed as part of the National Transportation Safety Board s failure investigation of the accident that occurred on November 12, 2001. The loads experienced by the right rear lug are evaluated using global models of the vertical tail, local models near the right rear lug, and a global-local analysis procedure. The right rear lug was analyzed using two modeling approaches. In the first approach, solid-shell type modeling is used, and in the second approach, layered-shell type modeling is used. The solid-shell and the layered-shell modeling approaches were used in progressive failure analyses (PFA) to determine the load, mode, and location of failure in the right rear lug under loading representative of an Airbus certification test conducted in 1985 (the 1985-certification test). Both analyses were in excellent agreement with each other on the predicted failure loads, failure mode, and location of failure. The solid-shell type modeling was then used to analyze both a subcomponent test conducted by Airbus in 2003 (the 2003-subcomponent test) and the accident condition. Excellent agreement was observed between the analyses and the observed failures in both cases. From the analyses conducted and presented in this paper, the following conclusions were drawn. The moment, Mx (moment about the fuselage longitudinal axis), has significant effect on the failure load of the lugs. Higher absolute values of Mx give lower failure loads. The predicted load, mode, and location of the failure of the 1985-certification test, 2003-subcomponent test, and the accident condition are in very good agreement. This agreement suggests that the 1985-certification and 2003- subcomponent tests represent the accident condition accurately. The failure mode of the right rear lug for the 1985-certification test, 2003-subcomponent test, and the accident load case is identified as a cleavage-type failure. For the accident case, the predicted failure load for the right rear lug from the PFA is greater than 1.98 times the limit load of the lugs. I.

Characteristics of Hydrogen Monitoring Systems for Severe Accident Management at a Nuclear Power Plant

NASA Astrophysics Data System (ADS)

Petrosyan, V. G.; Yeghoyan, E. A.; Grigoryan, A. D.; Petrosyan, A. P.; Movsisyan, M. R.

2018-02-01

One of the main objectives of severe accident management at a nuclear power plant is to protect the integrity of the containment, for which the most serious threat is possible ignition of the generated hydrogen. There should be a monitoring system providing information support of NPP personnel, ensuring data on the current state of a containment gaseous environment and trends in its composition changes. Monitoring systems' requisite characteristics definition issues are considered by the example of a particular power unit. Major characteristics important for proper information support are discussed. Some features of progression of severe accident scenarios at considered power unit are described and a possible influence of the hydrogen concentration monitoring system performance on the information support reliability in a severe accident is analyzed. The analysis results show that the following technical characteristics of the combustible gas monitoring systems are important for the proper information support of NPP personnel in the event of a severe accident at a nuclear power plant: measured parameters, measuring ranges and errors, update rate, minimum detectable concentration of combustible gas, monitoring reference points, environmental qualification parameters of the system components. For NPP power units with WWER-440/270 (230) type reactors, which have a relatively small containment volume, the update period for measurement results is a critical characteristic of the containment combustible gas monitoring system, and the choice of monitoring reference points should be focused not so much on the definition of places of possible hydrogen pockets but rather on the definition of places of a possible combustible mixture formation. It may be necessary for the above-mentioned power units to include in the emergency operating procedures measures aimed at a timely heat removal reduction from the containment environment if there are signs of a severe accident phase approaching to prevent a combustible mixture formation in the containment.

Clinical aspects of the health disturbances in Chernobyl Nuclear Power Plant accident clean-up workers (liquidators) from Latvia.

PubMed

Eglite, M E; Zvagule, T J; Rainsford, K D; Reste, J D; Curbakova, E V; Kurjane, N N

2009-06-01

The health status of some 6,000 workers from Latvia who went to clean-up the Chernobyl Nuclear Power Plant (CNPP) site following the explosion on 26 April 1986 has been analyzed. The data on these workers have been recorded in the Latvian State Register of Occupational disease patients and people exposed to ionizing radiation due to Chernobyl NPP accident (Latvian State Register) that was established in 1994. From these data, estimates have been made of external ionizing radiation to which these workers were exposed together with observations on the impact of exposure to heavy metals (especially lead and zinc) and radioactive isotopes released during the reactor 'meltdown'. These factors along with psycho-emotional and social-economic stresses account for a marked excess of mortality and morbidity in the group of CNPP accident clean-up workers compared with that of the non-exposed normal Latvian population adjusted for age and sex. The number of diseases or conditions in the CNPP accident clean-up workers has progressively risen from an average of 1.3 in 1986 to 10.9 in 2007. This exceeds for the Latvian population when adjusted for age and sex. The most serious conditions affect the nervous, digestive, respiratory, cardiovascular, endocrine (especially thyroid) and immunological systems. While the morbidity associated with diseases of the respiratory and digestive systems has decreased in recent years that in the other systems is increasing. In recent years, there has been an increased occurrence of cancers affecting the thyroid, prostate and stomach. Clinical and laboratory investigations suggest that surviving CNPP accident clean-up workers exhibit signs of immuno-inflammatory reactions causing premature aging with evidence of autoimmune diseases and immunological deficiencies or abnormalities. It is suggested that the CNPP accident clean-up workers may have a specific syndrome, the 'Chernobyl post-radiation neurosomatic polypathy', due to sustained oxidant stress injury, as a result of exposure to radiation and lead.

Development of Thin-Walled Magnesium Alloy Extrusions for Improved Crash Performance Based Upon Texture Control

NASA Astrophysics Data System (ADS)

Williams, Bruce W.; Agnew, Sean R.; Klein, Robert W.; McKinley, Jonathan

Recent investigations suggest that it is possible to achieve dramatic modifications to both strength and ductility of magnesium alloys through a combination of alloying, grain refinement, and texture control. The current work explores the possibility of altering the texture in extruded thin-walled magnesium alloy tubes for improved ductility during axial crush in which energy is absorbed through progressive buckling. The texture evolution was predicted using the viscoplastic self-consistent (VPSC) crystal plasticity model, with strain path input from continuum-based finite element simulations of extrusion. A limited diversity of textures can be induced by altering the strain path through the extrusion die design. In some cases, such as for simple bar extrusion, the textures predicted can be connected with simple shape change. In other cases, a subtle influence of strain path involving shear-reverse-shear is predicted. The most promising textures predicted for a variety of strain paths are selected for subsequent experimental study.

Office of Biological and Physical Research: Overview Transitioning to the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Crouch, Roger

2004-01-01

Viewgraphs on NASA's transition to its vision for space exploration is presented. The topics include: 1) Strategic Directives Guiding the Human Support Technology Program; 2) Progressive Capabilities; 3) A Journey to Inspire, Innovate, and Discover; 4) Risk Mitigation Status Technology Readiness Level (TRL) and Countermeasures Readiness Level (CRL); 5) Biological And Physical Research Enterprise Aligning With The Vision For U.S. Space Exploration; 6) Critical Path Roadmap Reference Missions; 7) Rating Risks; 8) Current Critical Path Roadmap (Draft) Rating Risks: Human Health; 9) Current Critical Path Roadmap (Draft) Rating Risks: System Performance/Efficiency; 10) Biological And Physical Research Enterprise Efforts to Align With Vision For U.S. Space Exploration; 11) Aligning with the Vision: Exploration Research Areas of Emphasis; 12) Code U Efforts To Align With The Vision For U.S. Space Exploration; 13) Types of Critical Path Roadmap Risks; and 14) ISS Human Support Systems Research, Development, and Demonstration. A summary discussing the vision for U.S. space exploration is also provided.

Concentrations and speciation of arsenic along a groundwater flow-path in the Upper Floridan aquifer, Florida, USA

NASA Astrophysics Data System (ADS)

Haque, S. E.; Johannesson, K. H.

2006-05-01

Arsenic (As) concentrations and speciation were determined in groundwaters along a flow-path in the Upper Floridan aquifer (UFA) to investigate the biogeochemical “evolution“ of As in this relatively pristine aquifer. Dissolved inorganic As species were separated in the field using anion-exchange chromatography and subsequently analyzed by inductively coupled plasma mass spectrometry. Total As concentrations are higher in the recharge area groundwaters compared to down-gradient portions of UFA. Redox conditions vary from relatively oxic to anoxic along the flow-path. Mobilization of As species in UFA groundwaters is influenced by ferric iron reduction and subsequent dissolution, sulfate reduction, and probable pyrite precipitation that are inferred from the data to occur along distinct regions of the flow-path. In general, the distribution of As species are consistent with equilibrium thermodynamics, such that arsenate dominates in more oxidizing waters near the recharge area, and arsenite predominates in the progressively reducing groundwaters beyond the recharge area.

CFIT Prevention Using Synthetic Vision

NASA Technical Reports Server (NTRS)

Arthur, Jarvis J., III; Prinzel, Lawrence J., III; Kramer, Lynda J.; Bailey, Randall E.; Parrish, Russell V.

2003-01-01

In commercial aviation, over 30-percent of all fatal accidents worldwide are categorized as Controlled Flight Into Terrain (CFIT) accidents where a fully functioning airplane is inadvertently flown into the ground, water, or an obstacle. An experiment was conducted at NASA Langley Research Center investigating the presentation of a synthetic terrain database scene to the pilot on a Primary Flight Display (PFD). The major hypothesis for the experiment is that a synthetic vision system (SVS) will improve the pilot s ability to detect and avoid a potential CFIT compared to conventional flight instrumentation. All display conditions, including the baseline, contained a Terrain Awareness and Warning System (TAWS) and Vertical Situation Display (VSD) enhanced Navigation Display (ND). Sixteen pilots each flew 22 approach - departure maneuvers in Instrument Meteorological Conditions (IMC) to the terrain challenged Eagle County Regional Airport (EGE) in Colorado. For the final run, the flight guidance cues were altered such that the departure path went into the terrain. All pilots with a SVS enhanced PFD (12 of 16 pilots) noticed and avoided the potential CFIT situation. All of the pilots who flew the anomaly with the baseline display configuration (which included a TAWS and VSD enhanced ND) had a CFIT event.

Virtual reality technology prevents accidents in extreme situations

NASA Astrophysics Data System (ADS)

Badihi, Y.; Reiff, M. N.; Beychok, S.

2012-03-01

This research is aimed at examining the added value of using Virtual Reality (VR) in a driving simulator to prevent road accidents, specifically by improving drivers' skills when confronted with extreme situations. In an experiment, subjects completed a driving scenario using two platforms: A 3-D Virtual Reality display system using an HMD (Head-Mounted Display), and a standard computerized display system based on a standard computer monitor. The results show that the average rate of errors (deviating from the driving path) in a VR environment is significantly lower than in the standard one. In addition, there was no compensation between speed and accuracy in completing the driving mission. On the contrary: The average speed was even slightly faster in the VR simulation than in the standard environment. Thus, generally, despite the lower rate of deviation in VR setting, it is not achieved by driving slower. When the subjects were asked about their personal experiences from the training session, most of the subjects responded that among other things, the VR session caused them to feel a higher sense of commitment to the task and their performance. Some of them even stated that the VR session gave them a real sensation of driving.

Containment Sodium Chemistry Models in MELCOR.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Louie, David; Humphries, Larry L.; Denman, Matthew R

To meet regulatory needs for sodium fast reactors’ future development, including licensing requirements, Sandia National Laboratories is modernizing MELCOR, a severe accident analysis computer code developed for the U.S. Nuclear Regulatory Commission (NRC). Specifically, Sandia is modernizing MELCOR to include the capability to model sodium reactors. However, Sandia’s modernization effort primarily focuses on the containment response aspects of the sodium reactor accidents. Sandia began modernizing MELCOR in 2013 to allow a sodium coolant, rather than water, for conventional light water reactors. In the past three years, Sandia has been implementing the sodium chemistry containment models in CONTAIN-LMR, a legacy NRCmore » code, into MELCOR. These chemistry models include spray fire, pool fire and atmosphere chemistry models. Only the first two chemistry models have been implemented though it is intended to implement all these models into MELCOR. A new package called “NAC” has been created to manage the sodium chemistry model more efficiently. In 2017 Sandia began validating the implemented models in MELCOR by simulating available experiments. The CONTAIN-LMR sodium models include sodium atmosphere chemistry and sodium-concrete interaction models. This paper presents sodium property models, the implemented models, implementation issues, and a path towards validation against existing experimental data.« less

Survey of Thermal-Fluids Evaluation and Confirmatory Experimental Validation Requirements of Accident Tolerant Cladding Concepts with Focus on Boiling Heat Transfer Characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Nicholas R.; Wysocki, Aaron J.; Terrani, Kurt A.

The U.S. Department of Energy Office of Nuclear Energy (DOE-NE) Advanced Fuels Campaign (AFC) is working closely with the nuclear industry to develop fuel and cladding candidates with potentially enhanced accident tolerance, also known as accident tolerant fuel (ATF). Thermal-fluids characteristics are a vital element of a holistic engineering evaluation of ATF concepts. One vital characteristic related to boiling heat transfer is the critical heat flux (CHF). CHF plays a vital role in determining safety margins during normal operation and also in the progression of potential transient or accident scenarios. This deliverable is a scoping survey of thermal-fluids evaluation andmore » confirmatory experimental validation requirements of accident tolerant cladding concepts with a focus on boiling heat transfer characteristics. The key takeaway messages of this report are: 1. CHF prediction accuracy is important and the correlations may have significant uncertainty. 2. Surface conditions are important factors for CHF, primarily the wettability that is characterized by contact angle. Smaller contact angle indicates greater wettability, which increases the CHF. Surface roughness also impacts wettability. Results in the literature for pool boiling experiments indicate changes in CHF by up to 60% for several ATF cladding candidates. 3. The measured wettability of FeCrAl (i.e., contact angle and roughness) indicates that CHF should be investigated further through pool boiling and flow boiling experiments. 4. Initial measurements of static advancing contact angle and surface roughness indicate that FeCrAl is expected to have a higher CHF than Zircaloy. The measured contact angle of different FeCrAl alloy samples depends on oxide layer thickness and composition. The static advancing contact angle tends to decrease as the oxide layer thickness increases.« less

Longitudinal Associations Between PTSD Symptoms and Dyadic Conflict Communication Following a Severe Motor Vehicle Accident.

PubMed

Fredman, Steffany J; Beck, J Gayle; Shnaider, Philippe; Le, Yunying; Pukay-Martin, Nicole D; Pentel, Kimberly Z; Monson, Candice M; Simon, Naomi M; Marques, Luana

2017-03-01

There are well-documented associations between posttraumatic stress disorder (PTSD) symptoms and intimate relationship impairments, including dysfunctional communication at times of relationship conflict. To date, the extant research on the associations between PTSD symptom severity and conflict communication has been cross-sectional and focused on military and veteran couples. No published work has evaluated the extent to which PTSD symptom severity and communication at times of relationship conflict influence each other over time or in civilian samples. The current study examined the prospective bidirectional associations between PTSD symptom severity and dyadic conflict communication in a sample of 114 severe motor vehicle accident (MVA) survivors in a committed intimate relationship at the time of the accident. PTSD symptom severity and dyadic conflict communication were assessed at 4 and 16weeks post-MVA, and prospective associations were examined using path analysis. Total PTSD symptom severity at 4weeks prospectively predicted greater dysfunctional communication at 16weeks post-MVA but not vice versa. Examination at the level of PTSD symptom clusters revealed that effortful avoidance at 4weeks prospectively predicted greater dysfunctional communication at 16weeks, whereas dysfunctional communication 4weeks after the MVA predicted more severe emotional numbing at 16weeks. Findings highlight the role of PTSD symptoms in contributing to dysfunctional communication and the importance of considering PTSD symptom clusters separately when investigating the dynamic interplay between PTSD symptoms and relationship functioning over time, particularly during the early posttrauma period. Clinical implications for the prevention of chronic PTSD and associated relationship problems are discussed. Copyright © 2016. Published by Elsevier Ltd.

[Peripheral vertigo versus central vertigo. Application of the HINTS protocol].

PubMed

Batuecas-Caletrío, Ángel; Yáñez-González, Raquel; Sánchez-Blanco, Carmen; González-Sánchez, Enrique; Benito, José; Gómez, José Carlos; Santa Cruz-Ruiz, Santiago

2014-10-16

One of the most important dilemmas concerning vertigo in emergency departments is its differential diagnosis. There are highly sensitive warning signs in the examination that can put us on the path towards finding ourselves before a case of central vertigo. To determine how effective the application of the HINTS protocol is in the diagnosis of cerebrovascular accidents that mimics peripheral vertigo. We conducted a descriptive observation-based study on patients admitted to hospital with a diagnosis of acute vestibular syndrome in the emergency department. All the patients were monitored on a day-to-day basis until their symptoms improved, with information about nystagmus, the oculocephalic manoeuvre and the skew test. The results from the magnetic resonance imaging study were compared with the alteration of any of those three signs during the time the patient was hospitalised. Altogether 91 patients were examined, with a mean age of 55.8 years. A cerebrovascular accident was observed in eight cases. Of these (mean age: 71 years), in seven of them there were alterations in some of the HINTS signs, and in one case the study was normal (sensitivity: 0.88; specificity: 0.96). All of them had some vascular risk factor. Faced with a patient who visits the emergency department with an acute vestibular syndrome, a suitably directed examination is essential to be able to establish the differential diagnosis between peripheral and central pathology, since some cerebrovascular accidents can present with the appearance of acute vertigo. Applying a protocol like HINTS makes it possible to suspect the central pathology with a high degree of sensitivity and specificity.

Science Within Man's Grasp: a Precondition to Progress

ERIC Educational Resources Information Center

de Roulet, Lionel

1972-01-01

Everyone should be aware of the explosive growth of science with its effects in daily life and the sweeping changes it will produce in the near future. Achievement of this aim calls for action along the dual paths of popularization and education. (DF)

Developmental Neurotoxicity Testing: A Path Forward

EPA Science Inventory

Great progress has been made over the past 40 years in understanding the hazards of exposure to a small number of developmental neurotoxicants. Lead, PCBs, and methylmercury are all good examples of science-based approaches to characterizing the hazard to the developing nervous s...

Nuclear safety. Technical progress journal, October 1996--December 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The five papers in this issue address various issues associated with the behavior of high burnup fuels, especially under reactivity initiated accident (RIA) conditions. The mechanisms and parameters that have an effect on the fuel behavior are detailed, based on tests and analyses. The ultimate goal of the research reported is the development of new regulatory criteria for high burnup fuel under design basis accident conditions. Specific topics of the papers, which are abstracted individually in the database, are: (1) regulatory assessment of test data for RIAs, (2) high burnup fuel transient behavior under RIA conditions, (3) NSRR/RIA experiments withmore » high burnup PWR fuels, (4) the Russian RIA research program, and (5) RIA simulation experiments on the intermediate and high burnup test rods. The papers are contributed from the United States, France, Japan, and Russia.« less

Crew/Automation Interaction in Space Transportation Systems: Lessons Learned from the Glass Cockpit

NASA Technical Reports Server (NTRS)

Rudisill, Marianne

2000-01-01

The progressive integration of automation technologies in commercial transport aircraft flight decks - the 'glass cockpit' - has had a major, and generally positive, impact on flight crew operations. Flight deck automation has provided significant benefits, such as economic efficiency, increased precision and safety, and enhanced functionality within the crew interface. These enhancements, however, may have been accrued at a price, such as complexity added to crew/automation interaction that has been implicated in a number of aircraft incidents and accidents. This report briefly describes 'glass cockpit' evolution. Some relevant aircraft accidents and incidents are described, followed by a more detailed description of human/automation issues and problems (e.g., crew error, monitoring, modes, command authority, crew coordination, workload, and training). This paper concludes with example principles and guidelines for considering 'glass cockpit' human/automation integration within space transportation systems.

Acoustics Discipline Overview

NASA Technical Reports Server (NTRS)

Envia, Edmane; Thomas, Russell

2007-01-01

As part of the Fundamental Aeronautics Program Annual Review, a summary of the progress made in 2007 in acoustics research under the Subsonic Fixed Wing project is given. The presentation describes highlights from in-house and external activities including partnerships and NRA-funded research with industry and academia. Brief progress reports from all acoustics Phase 1 NRAs are also included as are outlines of the planned activities for 2008 and all Phase 2 NRAs. N+1 and N+2 technology paths outlined for Subsonic Fixed Wing noise targets. NRA Round 1 progressing with focus on prediction method advancement. NRA Round 2 initiating work focused on N+2 technology, prediction methods, and validation. Excellent partnerships in progress supporting N+1 technology targets and providing key data sets.

Severe Accident Scoping Simulations of Accident Tolerant Fuel Concepts for BWRs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.

2015-08-01

Accident-tolerant fuels (ATFs) are fuels and/or cladding that, in comparison with the standard uranium dioxide Zircaloy system, can tolerate loss of active cooling in the core for a considerably longer time period while maintaining or improving the fuel performance during normal operations [1]. It is important to note that the currently used uranium dioxide Zircaloy fuel system tolerates design basis accidents (and anticipated operational occurrences and normal operation) as prescribed by the US Nuclear Regulatory Commission. Previously, preliminary simulations of the plant response have been performed under a range of accident scenarios using various ATF cladding concepts and fully ceramicmore » microencapsulated fuel. Design basis loss of coolant accidents (LOCAs) and station blackout (SBO) severe accidents were analyzed at Oak Ridge National Laboratory (ORNL) for boiling water reactors (BWRs) [2]. Researchers have investigated the effects of thermal conductivity on design basis accidents [3], investigated silicon carbide (SiC) cladding [4], as well as the effects of ATF concepts on the late stage accident progression [5]. These preliminary analyses were performed to provide initial insight into the possible improvements that ATF concepts could provide and to identify issues with respect to modeling ATF concepts. More recently, preliminary analyses for a range of ATF concepts have been evaluated internationally for LOCA and severe accident scenarios for the Chinese CPR1000 [6] and the South Korean OPR-1000 [7] pressurized water reactors (PWRs). In addition to these scoping studies, a common methodology and set of performance metrics were developed to compare and support prioritizing ATF concepts [8]. A proposed ATF concept is based on iron-chromium-aluminum alloys (FeCrAl) [9]. With respect to enhancing accident tolerance, FeCrAl alloys have substantially slower oxidation kinetics compared to the zirconium alloys typically employed. During a severe accident, FeCrAl would tend to generate heat and hydrogen from oxidation at a slower rate compared to the zirconium-based alloys in use today. The previous study, [2], of the FeCrAl ATF concept during station blackout (SBO) severe accident scenarios in BWRs was based on simulating short term SBO (STSBO), long term SBO (LTSBO), and modified SBO scenarios occurring in a BWR-4 reactor with MARK-I containment. The analysis indicated that FeCrAl had the potential to delay the onset of fuel failure by a few hours depending on the scenario, and it could delay lower head failure by several hours. The analysis demonstrated reduced in-vessel hydrogen production. However, the work was preliminary and was based on limited knowledge of material properties for FeCrAl. Limitations of the MELCOR code were identified for direct use in modeling ATF concepts. This effort used an older version of MELCOR (1.8.5). Since these analyses, the BWR model has been updated for use in MELCOR 1.8.6 [10], and more representative material properties for FeCrAl have been modeled. Sections 2 4 present updated analyses for the FeCrAl ATF concept response during severe accidents in a BWR. The purpose of the study is to estimate the potential gains afforded by the FeCrAl ATF concept during BWR SBO scenarios.« less

Theoretical analysis of the time-resolved binary (e, 2e) binding energy spectra on three-body photodissociation of acetone at 195 nm

NASA Astrophysics Data System (ADS)

Yamazaki, M.; Nakayama, S.; Zhu, C. Y.; Takahashi, M.

2017-11-01

We report on theoretical progress in time-resolved (e, 2e) electron momentum spectroscopy of photodissociation dynamics of the deuterated acetone molecule at 195 nm. We have examined the predicted minimum energy reaction path to investigate whether associated (e, 2e) calculations meet the experimental results. A noticeable difference between the experiment and calculations has been found at around binding energy of 10 eV, suggesting that the observed difference may originate, at least partly, in ever-unconsidered non-minimum energy paths.

Theory and Practice of Sustainable Development: Path to Managing Rural Grass-roots Party Organization from the Perspective of Impetus

NASA Astrophysics Data System (ADS)

Zhong, Xianzhe

2018-02-01

Impetus is the most fundamental guarantee for the survival and progress of organization. The rural grass-roots party organization should serve as a battle fortress of party helping realize the purpose of party in the village. Therefore, to strengthen the management of rural party branches, it is imperative to optimize their impetus, stepping on the basic paths: developing and utilizing material force, and digging and stimulating spiritual force for rural grass-roots party organization construction; adhering to the dialectical view on impetus to highlight both material and spiritual motivations.

Universal Health Coverage - The Critical Importance of Global Solidarity and Good Governance Comment on "Ethical Perspective: Five Unacceptable Trade-offs on the Path to Universal Health Coverage".

PubMed

Reis, Andreas A

2016-06-07

This article provides a commentary to Ole Norheim' s editorial entitled "Ethical perspective: Five unacceptable trade-offs on the path to universal health coverage." It reinforces its message that an inclusive, participatory process is essential for ethical decision-making and underlines the crucial importance of good governance in setting fair priorities in healthcare. Solidarity on both national and international levels is needed to make progress towards the goal of universal health coverage (UHC). © 2016 by Kerman University of Medical Sciences.

Long-time Dynamics of Stochastic Wave Breaking

NASA Astrophysics Data System (ADS)

Restrepo, J. M.; Ramirez, J. M.; Deike, L.; Melville, K.

2017-12-01

A stochastic parametrization is proposed for the dynamics of wave breaking of progressive water waves. The model is shown to agree with transport estimates, derived from the Lagrangian path of fluid parcels. These trajectories are obtained numerically and are shown to agree well with theory in the non-breaking regime. Of special interest is the impact of wave breaking on transport, momentum exchanges and energy dissipation, as well as dispersion of trajectories. The proposed model, ensemble averaged to larger time scales, is compared to ensemble averages of the numerically generated parcel dynamics, and is then used to capture energy dissipation and path dispersion.

Driver fatigue and highway driving: a simulator study.

PubMed

Ting, Ping-Huang; Hwang, Jiun-Ren; Doong, Ji-Liang; Jeng, Ming-Chang

2008-06-09

Long duration of driving is a significant cause of fatigue-related accidents on motorways or major roadways. The fatigue caused by driving for extended periods acutely impairs driver alertness and performance and can compromise transportation safety. This study quantitatively measured the progression of driver fatigue and identified the conservative safe duration of continuous highway driving. Thirty young male subjects were analyzed during 90 min of laboratory-simulated highway driving. Sleepiness ratings (SSS) and reaction time (RT) tests were used to assess impairment of driver alertness and vigilance. Additionally, various measures of driving performance recorded throughout the experiment were used to measure temporal deterioration of driver performance from alert to fatigued using principal component analysis (PCA). The analytical results revealed that SSS scores, reaction times (RTs) and unstable driving performance significantly increased over time, indicating that excessive driving time is a significant fatigue factor and potential cause of fatigue-related accidents. Moreover, the analytical results indicated that 80 min was the safe limit for monotonous highway driving. Based on the experimental findings of this study, public awareness of the adverse affects of driver fatigue during long-distance driving should be enhanced. This study provides explicit information of fatigue development that can be used to prevent fatigue-related accidents.

Flex Sensor Based Biofeedback Monitoring for Post-Stroke Fingers Myopathy Patients

NASA Astrophysics Data System (ADS)

Garda, Y. R.; Caesarendra, W.; Tjahjowidodo, T.; Turnip, A.; Wahyudati, S.; Nurhasanah, L.; Sutopo, D.

2018-04-01

Hands are one of the crucial parts of the human body in carrying out daily activities. Accidents on the hands decreasing in motor skills of the hand so that therapy is necessary to restore motor function of the hand. In addition to accidents, hand disabilities can be caused by certain diseases, e.g. stroke. Stroke is a partial destruction of the brain. It occurs if the arteries that drain blood to the brain are blocked, or if torn or leak. The purpose of this study to make biofeedback monitoring equipment for post-stroke hands myopathy patients. Biofeedback is an alternative method of treatment that involves measuring body functions measured subjects such as skin temperature, sweat activity, blood pressure, heart rate and hand paralysis due to stroke. In this study, the sensor used for biofeedback monitoring tool is flex sensor. Flex sensor is a passive resistive device that changes its resistance as the sensor is bent. Flex sensor converts the magnitude of the bend into electrical resistance, the greater the bend the greater the resistance value. The monitoring used in this biofeedback monitoring tool uses Graphical User Interface (GUI) in C# programming language. The motivation of the study is to monitor and record the progressive improvement of the hand therapy. Patients who experienced post-stroke can see the therapy progress quantitatively.

The occupational impact of sleep quality and insomnia symptoms.

PubMed

Kucharczyk, Erica R; Morgan, Kevin; Hall, Andrew P

2012-12-01

While the importance of assessing the occupational consequences of insomnia is emphasized in clinical nosologies and research guidelines, there is little consensus on which aspects of occupational performance should be assessed, the most methodologically justifiable measures of insomnia and work performance, and how outcomes should be reported. The present review was designed to summarize and methodologically critique the assessment of those aspects of occupational performance most impacted by (or most frequently associated with) insomnia symptoms. The 30 studies which met the review inclusion criteria broadly addressed six domains of occupational functioning: absenteeism; workplace accidents; productivity; punctuality; job satisfaction and career progression. Collectively, study outcomes support the conclusions that insomnia symptoms: are consistently associated with excess absenteeism; elevate accident risk in the workplace; reduce subjectively experienced workplace productivity (at least in the shorter term); inhibit career progression; and can degrade job satisfaction. Study outcomes do not support the conclusion that people with insomnia are significantly less punctual than other workers. The overall value of the occupational sleep-health literature, however, is limited by a lack of comparability among studies. In particular, there is a clear need to standardize definitions of sleep and occupational outcomes, and to recognize the confounding influence of health variables on occupational performance and sleep. Copyright © 2012 Elsevier Ltd. All rights reserved.

Computational Aerodynamics of Shuttle Orbiter Damage Scenarios in Support of the Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Bibb, Karen L.; Prabhu, Ramadas K.

2004-01-01

In support of the Columbia Accident Investigation, inviscid computations of the aerodynamic characteristics for various Shuttle Orbiter damage scenarios were performed using the FELISA unstructured CFD solver. Computed delta aerodynamics were compared with the reconstructed delta aerodynamics in order to postulate a progression of damage through the flight trajectory. By performing computations at hypervelocity flight and CF4 tunnel conditions, a bridge was provided between wind tunnel testing in Langley's 20-Inch CF4 facility and the flight environment experienced by Columbia during re-entry. The rapid modeling capability of the unstructured methodology allowed the computational effort to keep pace with the wind tunnel and, at times, guide the wind tunnel efforts. These computations provided a detailed view of the flowfield characteristics and the contribution of orbiter components (such as the vertical tail and wing) to aerodynamic forces and moments that were unavailable from wind tunnel testing. The damage scenarios are grouped into three categories. Initially, single and multiple missing full RCC panels were analyzed to determine the effect of damage location and magnitude on the aerodynamics. Next is a series of cases with progressive damage, increasing in severity, in the region of RCC panel 9. The final group is a set of wing leading edge and windward surface deformations that model possible structural deformation of the wing skin due to internal heating of the wing structure. By matching the aerodynamics from selected damage scenarios to the reconstructed flight aerodynamics, a progression of damage that is consistent with the flight data, debris forensics, and wind tunnel data is postulated.

Posttraumatic cerebral infarction due to progressive occlusion of the internal carotid artery after minor head injury in childhood: a case report.

PubMed

Matsumoto, Hiroaki; Kohno, Kanehisa

2011-07-01

Although minor head injury in childhood is a common occurrence and usually no complications, posttraumatic cerebral infarction has rarely been reported. Such infarction is characterized by occlusion of the lateral lenticulostriate artery. The authors report an atypical case of posttraumatic occlusion of the internal carotid artery (ICA) after minor head injury in childhood. A healthy 16-year-old boy was hit on the head by a pitch while playing baseball. He developed a transient ischemic attack involving the left extremities 15 min after the accident. Initial magnetic resonance imaging revealed neither hemorrhage nor infarction, and MR angiography demonstrated mild stenosis of the right carotid fork. Conservative therapy was started. However, 24 h after the accident, he suddenly developed left hemiparesis. Emergent neuroimaging demonstrated progressive occlusion of the supraclinoid portion of the right ICA and cerebral infarction of the deep white matter in the right frontal lobe. The hemiparesis deteriorated and the infarction area continued to expand on a daily. The patient underwent emergent superficial temporally artery-middle cerebral artery (STA-MCA) bypass. Intraoperative observation demonstrated that the supraclinoid portion of the right ICA was not thrombosed but pale with low tension and did not appear dissected. He fully recovered by 2 weeks after the operation. Postoperative investigations showed gradual improvement of the ICA occlusion. Minor head injury can cause cerebral infarction in childhood, although this is rare. If conservative therapy cannot prevent progressive cerebral infarction, STA-MCA bypass should be considered in case of the ICA occlusion.

Environmental policies to enhance technological change in the electricity sector

NASA Astrophysics Data System (ADS)

Sunol Del Rio, Eric

International agreements on climate change mitigation set quantitative carbon emission reduction targets in a country for a given year with respect to a given base year. A central question is then on what time do the new clean and costly technologies need to start functioning to comply with the agreed targets, and under what incentive does the market implement them. The planner's economic problem is to design an incentive that makes the new clean technology less costly than the vintage polluting facility, at the precise time in order to comply with the agreements at minimum cost. Chapter 1 reviews the literature on efficient allocation of pollution, discussing its validity to explain induced technological change. It then presents a simple model of technological change showing that market power determes the optimal adoption time of a new technology. Chapter 2 analyzes the effectiveness of carbon costs in accelerating technological change under different paths of technological progress. Furthermore, the paper examines the influence of market conditions. It shows that emission charges do reduce the firm's optimal adoption time when investment cost paths for the new technology are convex. On the contrary, emission charges may delay the optimal the switching time of a technology when the investment cost path is concave. Chapter 3 explores the results of Chapter 2 in an agent-based model. Simulations of firms adjusting their output a la Cournot show that the effectiveness of carbon costs in accelerating technological change is highly dependant on the number of firms in the market. Moreover, the shape of the technological progress curve is determinant: the effects of carbon charges are not linear on carbon price, and become more uncertain the more concave the investment cost path is. These results show that policies aiming at internalizing pollution costs enhance technological change at very different rates, depending on the actual market conditions in the industry and the dynamics of technological progress. This has profound implications in policy design: not only do carbon charges need to be used with precaution in oligopolistic industries, but also its effectiveness depends on the inner dynamics of cleaner technological alternatives.

Structural Analysis for the American Airlines Flight 587 Accident Investigation: Global Analysis

NASA Technical Reports Server (NTRS)

Young, Richard D.; Lovejoy, Andrew E.; Hilburger, Mark W.; Moore, David F.

2005-01-01

NASA Langley Research Center (LaRC) supported the National Transportation Safety Board (NTSB) in the American Airlines Flight 587 accident investigation due to LaRC's expertise in high-fidelity structural analysis and testing of composite structures and materials. A Global Analysis Team from LaRC reviewed the manufacturer s design and certification procedures, developed finite element models and conducted structural analyses, and participated jointly with the NTSB and Airbus in subcomponent tests conducted at Airbus in Hamburg, Germany. The Global Analysis Team identified no significant or obvious deficiencies in the Airbus certification and design methods. Analysis results from the LaRC team indicated that the most-likely failure scenario was failure initiation at the right rear main attachment fitting (lug), followed by an unstable progression of failure of all fin-to-fuselage attachments and separation of the VTP from the aircraft. Additionally, analysis results indicated that failure initiates at the final observed maximum fin loading condition in the accident, when the VTP was subjected to loads that were at minimum 1.92 times the design limit load condition for certification. For certification, the VTP is only required to support loads of 1.5 times design limit load without catastrophic failure. The maximum loading during the accident was shown to significantly exceed the certification requirement. Thus, the structure appeared to perform in a manner consistent with its design and certification, and failure is attributed to VTP loads greater than expected.

Whiplash injuries of the temporomandibular joint in motor vehicle accidents: speculations and facts.

PubMed

McKay, D C; Christensen, L V

1998-10-01

Referring to the temporomandibular joint (TMJ) of the human mandibular locomotor system, it has been asserted that displacement of the TMJ disc and inflammation of TMJ tissues are the results of acute and indirect trauma to the TMJ; on occasion this is allegedly experienced in motor vehicle accidents and commonly known as a TMJ whiplash injury. It is postulated that the TMJ whiplash injury is released in the occupant or occupants of a target vehicle when its rear end is impacted by the front end of a bullet vehicle. On the basis of detailed analyses of TMJ trauma/pain histories and TMJ magnetic resonance images, presented as circumstantial evidence in favour of the postulated TMJ whiplash injury, and detailed analyses of the mathematical biophysics of the mandibular locomotor system as well as direct experimental evidence, it is concluded that the postulated TMJ whiplash injury does not exist as a single and independent disease entity caused by motor vehicle accidents. If TMJ disc displacement and inflammation are present, they are expressions of an insidious and progressive pre-existing (pre-accident) disease entity that is comprised of TMJ synovitis/osteoarthritis (phase of inflammation with presence of immune system cells), TMJ internal derangement (phase of disc displacement and deformation with presence of proteinases), and TMJ osteoarthrosis (phase of degeneration with absence of immune system cells). For the asserted TMJ whiplash manoeuvre and ensuing injury to occur as postulated, the laws of physics and biology would have to be suspended.

Mortality from accidents, disease, suicide and homicide in the British fishing industry from 1900 to 2010.

PubMed

Roberts, Stephen E; Carter, Tim

2015-01-01

To establish the causes of mortality in the British fishing industry from 1900 up to 2010, to investigate long term trends in mortality and to identify causal factors in the mortality patterns and rates. A longitudinal study, based on examinations of official death inquiry files, marine accident investigation files and reports, death registers and annual death returns. Mortality rates from accidents while working at sea remain high in the British fishing industry. Over the twentieth century there has been a progressive fall in the numbers of deaths, much of this relates to changes in fishing methods and in the types of vessels used. However in recent years, and with a fleet of smaller vessels, the mortality rates from accidents have shown little change and a larger proportion of deaths than in the past have arisen from personal injuries and drowning as compared to vessel losses. Disease makes a relatively small contribution to mortality at sea and this has dwindled with the decline in distant water fishing. Suicide and homicide both feature in a small way, but rates cannot readily be compared with those ashore. The pattern of change in vessels, fisheries and fishing techniques over the study period are complex. However, improved injury and drowning prevention is the most important way to reduce deaths, coupled with attention to vessel stability and maintenance. The social, economic and organisational features of the fishing industry mean that securing improvements in these areas is a major challenge.

[Traumas in road accidents].

PubMed

Picardi, Nicola

2005-01-01

Road accidents are nowadays one of the most important cause of injuries, deaths and definitive invalidity, except the war casualties. All the developed countries are affected by this problems, and all the efforts are in progress to make aware the people, mostly the drivers, of all the possible preventive measures. Not all the accident are per se cause of death or invalidity, and there are a lot of evitable deaths and definite morbidity, but an incongruous help can worsen the outcome or menace the final validity and life itself. The injuries affect in different ways the driver and the passenger, and the same safety devices designed to protect the travellers, as safety belts and air bags, can hit them with peculiar mechanisms. A particular attention must be paid to the children, too often transported without the correct safety measures. Very important are the correct steps of the first aid, the succession of the treatment manoeuvres, and the environment were the patients can and must be treated. The Trauma Center represents an ideal solution for the best treatment, but its organization is far from simple, particularly in our country so different in the various regions as population, road, towns and villages distribution, especially in the mountainous districts. Every effort must be done to organize al the best the first, second and definite aid and treatment, together with the active and passive safety devices, and with a correct road education, to stop the true epidemic impact of the road accidents.

Core-melt source reduction system

DOEpatents

Forsberg, C.W.; Beahm, E.C.; Parker, G.W.

1995-04-25

A core-melt source reduction system for ending the progression of a molten core during a core-melt accident and resulting in a stable solid cool matrix. The system includes alternating layers of a core debris absorbing material and a barrier material. The core debris absorbing material serves to react with and absorb the molten core such that containment overpressurization and/or failure does not occur. The barrier material slows the progression of the molten core debris through the system such that the molten core has sufficient time to react with the core absorbing material. The system includes a provision for cooling the glass/molten core mass after the reaction such that a stable solid cool matrix results. 4 figs.

Core-melt source reduction system

DOEpatents

Forsberg, Charles W.; Beahm, Edward C.; Parker, George W.

1995-01-01

A core-melt source reduction system for ending the progression of a molten core during a core-melt accident and resulting in a stable solid cool matrix. The system includes alternating layers of a core debris absorbing material and a barrier material. The core debris absorbing material serves to react with and absorb the molten core such that containment overpressurization and/or failure does not occur. The barrier material slows the progression of the molten core debris through the system such that the molten core has sufficient time to react with the core absorbing material. The system includes a provision for cooling the glass/molten core mass after the reaction such that a stable solid cool matrix results.

Origins of Protein Functions in Cells

NASA Technical Reports Server (NTRS)

Seelig, Burchard; Pohorille, Andrzej

2011-01-01

In modern organisms proteins perform a majority of cellular functions, such as chemical catalysis, energy transduction and transport of material across cell walls. Although great strides have been made towards understanding protein evolution, a meaningful extrapolation from contemporary proteins to their earliest ancestors is virtually impossible. In an alternative approach, the origin of water-soluble proteins was probed through the synthesis and in vitro evolution of very large libraries of random amino acid sequences. In combination with computer modeling and simulations, these experiments allow us to address a number of fundamental questions about the origins of proteins. Can functionality emerge from random sequences of proteins? How did the initial repertoire of functional proteins diversify to facilitate new functions? Did this diversification proceed primarily through drawing novel functionalities from random sequences or through evolution of already existing proto-enzymes? Did protein evolution start from a pool of proteins defined by a frozen accident and other collections of proteins could start a different evolutionary pathway? Although we do not have definitive answers to these questions yet, important clues have been uncovered. In one example (Keefe and Szostak, 2001), novel ATP binding proteins were identified that appear to be unrelated in both sequence and structure to any known ATP binding proteins. One of these proteins was subsequently redesigned computationally to bind GTP through introducing several mutations that introduce targeted structural changes to the protein, improve its binding to guanine and prevent water from accessing the active center. This study facilitates further investigations of individual evolutionary steps that lead to a change of function in primordial proteins. In a second study (Seelig and Szostak, 2007), novel enzymes were generated that can join two pieces of RNA in a reaction for which no natural enzymes are known. Recently it was found that, as in the previous case, the proteins have a structure unknown among modern enzymes. In this case, in vitro evolution started from a small, non-enzymatic protein. A similar selection process initiated from a library of random polypeptides is in progress. These results not only allow for estimating the occurrence of function in random protein assemblies but also provide evidence for the possibility of alternative protein worlds. Extant proteins might simply represent a frozen accident in the world of possible proteins. Alternative collections of proteins, even with similar functions, could originate alternative evolutionary paths.

Sustainability Takes Time

ERIC Educational Resources Information Center

Downey, Peter R.

2004-01-01

This is a story of transformation at Sheffield Hallam University, UK. It describes the progress and thinking along the path to introducing the university's vision of sustainability since the conclusion of EMSU 1999. It describes how sustainable practice has been incorporated within the formal democratic structures of the university, and describes…

The Long and Winding Path (from Instructional Design to Performance Technology).

ERIC Educational Resources Information Center

Carr, Clay; Totzke, Larry

1995-01-01

Presents a case study based on experiences at Amway Corporation that explains how the Human Resources Development Department progressed from providing training to providing a broader range of human performance technology interventions. Strategic planning is described, including identifying incentives and required competencies, providing for…

Remediation of radiocesium-contaminated liquid waste, soil, and ash: a mini review since the Fukushima Daiichi Nuclear Power Plant accident.

PubMed

Ding, Dahu; Zhang, Zhenya; Lei, Zhongfang; Yang, Yingnan; Cai, Tianming

2016-02-01

The radiation contamination after the Fukushima Daiichi Nuclear Power Plant accident attracts considerable concern all over the world. Many countries, areas, and oceans are greatly affected by the emergency situation other than Japan. An effective remediation strategy is in a highly urgent demand. Though plenty of works have been carried out, progressive achievements have not yet been well summarized. Here, we review the recent advances on the remediation of radiocesium-contaminated liquid waste, soil, and ash. The overview of the radiation contamination is firstly given. Afterwards, the current remediation strategies are critically reviewed in terms of the environmental medium. Special attentions are paid on the adsorption/ion exchange and electrically switched ion exchange methods. Finally, the present review outlines the possible works to do for the large-scale application of the novel remediation strategies.

Rehabilitation R and D Progress Reports, 1991

DTIC Science & Technology

1991-01-01

FES) is a challeng- work of our group , we are addressing the problem ing problem. A crucial difficulty is controlling the of designing a functional FES... control data. Background infor- research to design and evaluate interventions which mation will be obtained on the visual, sensory, help to reduce the...the senior was randomly Larger scale research is planned to investigate assigned to either a control or service group . the incidence of minor accidents

Regulating the path from legacy recognition, through recovery to release from regulatory control.

PubMed

Sneve, Malgorzata Karpow; Smith, Graham

2015-04-01

Past development of processes and technologies using radioactive material led to construction of many facilities worldwide. Some of these facilities were built and operated before the regulatory infrastructure was in place to ensure adequate control of radioactive material during operation and decommissioning. In other cases, controls were in place but did not meet modern standards, leading to what is now considered to have been inadequate control. Accidents and other events have occurred resulting in loss of control of radioactive material and unplanned releases to the environment. The legacy from these circumstances is that many countries have areas or facilities at which abnormal radiation conditions exist at levels that give rise to concerns about environmental and human health of potential interest to regulatory authorities. Regulation of these legacy situations is complex. This paper examines the regulatory challenges associated with such legacy management and brings forward suggestions for finding the path from: legacy recognition; implementation, as necessary, of urgent mitigation measures; development of a longer-term management strategy, through to release from regulatory control. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Ground-based Photon Path Measurements from Solar Absorption Spectra of the O2 A-band

NASA Technical Reports Server (NTRS)

Yang, Z.; Wennberg, P. O.; Cageao, R. P.; Pongetti, T. J.; Toon, G. C.; Sander, S. P.

2005-01-01

High-resolution solar absorption spectra obtained from Table Mountain Facility (TMF, 34.38degN, 117.68degW, 2286 m elevation) have been analyzed in the region of the O2 A-band. The photon paths of direct sunlight in clear sky cases are retrieved from the O2 absorption lines and compared with ray-tracing calculations based on the solar zenith angle and surface pressure. At a given zenith angle, the ratios of retrieved to geometrically derived photon paths are highly precise (approx.0.2%), but they vary as the zenith angle changes. This is because current models of the spectral lineshape in this band do not properly account for the significant absorption that exists far from the centers of saturated lines. For example, use of a Voigt function with Lorentzian far wings results in an error in the retrieved photon path of as much as 5%, highly correlated with solar zenith angle. Adopting a super-Lorentz function reduces, but does not completely eliminate this problem. New lab measurements of the lineshape are required to make further progress.

Three Case Studies in Making Fair Choices on the Path to Universal Health Coverage.

PubMed

Voorhoeve, Alex; Edejer, Tessa T T; Kapiriri, Lydia; Norheim, Ole F; Snowden, James; Basenya, Olivier; Bayarsaikhan, Dorjsuren; Chentaf, Ikram; Eyal, Nir; Folsom, Amanda; Tun Hussein, Rozita Halina; Morales, Cristian; Ostmann, Florian; Ottersen, Trygve; Prakongsai, Phusit; Saenz, Carla; Saleh, Karima; Sommanustweechai, Angkana; Wikler, Daniel; Zakariah, Afisah

2016-12-01

The goal of achieving Universal Health Coverage (UHC) can generally be realized only in stages. Moreover, resource, capacity, and political constraints mean governments often face difficult trade-offs on the path to UHC. In a 2014 report, Making fair choices on the path to UHC , the WHO Consultative Group on Equity and Universal Health Coverage articulated principles for making such trade-offs in an equitable manner. We present three case studies which illustrate how these principles can guide practical decision-making. These case studies show how progressive realization of the right to health can be effectively guided by priority-setting principles, including generating the greatest total health gain, priority for those who are worse off in a number of dimensions (including health, access to health services, and social and economic status), and financial risk protection. They also demonstrate the value of a fair and accountable process of priority setting.

Three Case Studies in Making Fair Choices on the Path to Universal Health Coverage

PubMed Central

Edejer, Tessa T.T.; Kapiriri, Lydia; Norheim, Ole F.; Snowden, James; Basenya, Olivier; Bayarsaikhan, Dorjsuren; Chentaf, Ikram; Eyal, Nir; Folsom, Amanda; Tun Hussein, Rozita Halina; Morales, Cristian; Ostmann, Florian; Ottersen, Trygve; Prakongsai, Phusit; Saenz, Carla; Saleh, Karima; Sommanustweechai, Angkana; Wikler, Daniel; Zakariah, Afisah

2016-01-01

Abstract The goal of achieving Universal Health Coverage (UHC) can generally be realized only in stages. Moreover, resource, capacity, and political constraints mean governments often face difficult trade-offs on the path to UHC. In a 2014 report, Making fair choices on the path to UHC, the WHO Consultative Group on Equity and Universal Health Coverage articulated principles for making such trade-offs in an equitable manner. We present three case studies which illustrate how these principles can guide practical decision-making. These case studies show how progressive realization of the right to health can be effectively guided by priority-setting principles, including generating the greatest total health gain, priority for those who are worse off in a number of dimensions (including health, access to health services, and social and economic status), and financial risk protection. They also demonstrate the value of a fair and accountable process of priority setting. PMID:28559673

An iterative learning control method with application for CNC machine tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, D.I.; Kim, S.

1996-01-01

A proportional, integral, and derivative (PID) type iterative learning controller is proposed for precise tracking control of industrial robots and computer numerical controller (CNC) machine tools performing repetitive tasks. The convergence of the output error by the proposed learning controller is guaranteed under a certain condition even when the system parameters are not known exactly and unknown external disturbances exist. As the proposed learning controller is repeatedly applied to the industrial robot or the CNC machine tool with the path-dependent repetitive task, the distance difference between the desired path and the actual tracked or machined path, which is one ofmore » the most significant factors in the evaluation of control performance, is progressively reduced. The experimental results demonstrate that the proposed learning controller can improve machining accuracy when the CNC machine tool performs repetitive machining tasks.« less

Redefining "Early Career" in Academia: A Collective Narrative Approach

ERIC Educational Resources Information Center

Bosanquet, Agnes; Mailey, Alana; Matthews, Kelly E.; Lodge, Jason M.

2017-01-01

"Early career" in academia is typically defined in terms of research capability in the five years following PhD completion, with career progression from post-doctoral appointment to tenure, promotion and beyond. This ideal path assumes steady employment and continuous research development. With academic work increasingly casualised,…

Cueing Animations: Dynamic Signaling Aids Information Extraction and Comprehension

ERIC Educational Resources Information Center

Boucheix, Jean-Michel; Lowe, Richard K.; Putri, Dian K.; Groff, Jonathan

2013-01-01

The effectiveness of animations containing two novel forms of animation cueing that target relations between event units rather than individual entities was compared with that of animations containing conventional entity-based cueing or no cues. These relational event unit cues ("progressive path" and "local coordinated" cues) were specifically…

It's No Secret: Progress Prized in Brownsville

ERIC Educational Resources Information Center

Zehr, Mary Ann

2008-01-01

This article features Brownsville Independent School District which was awarded the prestigious 2008 Broad Prize for Urban Education for being the nation's most improved urban school district. The Texas border district sees teacher training and data-based instruction as paths to learning gains--and the $1 million Broad award adds validation. In…

Canada's Composite Learning Index: A Path Towards Learning Communities

ERIC Educational Resources Information Center

Cappon, Paul; Laughlin, Jarrett

2013-01-01

In the development of learning cities/communities, benchmarking progress is a key element. Not only does it permit cities/communities to assess their current strengths and weaknesses, it also engenders a dialogue within and between cities/communities on the means of enhancing learning conditions. Benchmarking thereby is a potentially motivational…

Career Counseling in a Volatile Job Market: Tiedeman's Perspective Revisited

ERIC Educational Resources Information Center

Duys, David K.; Ward, Janice E.; Maxwell, Jane A.; Eaton-Comerford, Leslie

2008-01-01

This article explores implications of Tiedeman's original theory for career counselors. Some components of the theory seem to be compatible with existing volatile job market conditions. Notions of career path recycling, development in reverse, nonlinear progress, and parallel streams in career development are explored. Suggestions are made for…

Developing an Action Concept Inventory

ERIC Educational Resources Information Center

McGinness, Lachlan P.; Savage, C. M.

2016-01-01

We report on progress towards the development of an Action Concept Inventory (ACI), a test that measures student understanding of action principles in introductory mechanics and optics. The ACI also covers key concepts of many-paths quantum mechanics, from which classical action physics arises. We used a multistage iterative development cycle for…

Challenges on the Path to Implementation

ERIC Educational Resources Information Center

Martineau, Joseph A.; Wyse, Adam E.

2015-01-01

This article is a commentary of a paper by Derek C. Briggs and Frederick A. Peck, "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth," which describes an elegant potential framework for at least beginning to address three priorities in large-scale assessment that have not been…

Interior-Point Methods for Linear Programming: A Review

ERIC Educational Resources Information Center

Singh, J. N.; Singh, D.

2002-01-01

The paper reviews some recent advances in interior-point methods for linear programming and indicates directions in which future progress can be made. Most of the interior-point methods belong to any of three categories: affine-scaling methods, potential reduction methods and central path methods. These methods are discussed together with…

Motorcycle right-of-way accidents--a literature review.

PubMed

Pai, Chih-Wei

2011-05-01

The most typical automobile-motorcycle collision take places when an automobile manoeuvres into the path of an approaching motorcycle by violating the motorcycle's right of way (ROW). The present paper provides a comprehensive review of past research that examined motorcycle ROW accidents. Articles and publications were selected for relevance and research strength through a comprehensive search of major databases such as Transportation Research Information Services (TRIS), Compendex, and Medline. Two major causes of such a crash scenario are the lack of motorcycle conspicuity and motorist's speed/distance judgment error, respectively. A substantial number of studies have manipulated physical characteristics of motorcycles and motorcyclists to enhance conspicuity, along with research addressing motorists' gap-acceptance behaviours and arrival time judgments when confronting motorcycles. Although various conspicuity aids have proven effective, some researchers reported that motorcyclist's/motorcycle's brightness per se may be less important as a determinant of conspicuity than brightness contrast between the motorcyclists and the surroundings. Larger vehicles tended to be judged to arrive sooner than motorcycles. Such a speed/distance judgment error is likely attributable to some psychological effects such that larger automobiles appear more threatening than motorcycles. Older motorists particularly have difficulties in accurately estimating the distance and the speed of an approaching motorcycle. Research examining the effects of conspicuity measures on motorists' speed/distance judgments when confronting motorcycles has been rather inconclusive. Past research offers valuable insight into the underlying motorcycle ROW crash mechanisms. However, with ageing society and a rapid change in traffic composition (e.g., more larger motorcycles) in recent years, prior research findings should be updated. The present study finally provides recommendations for future research on motorcycle ROW accidents. Copyright © 2010 Elsevier Ltd. All rights reserved.

A progress report on the development of an augmentor wing jet STOL research aircraft.

NASA Technical Reports Server (NTRS)

Quigley, H. C.; Sinclair, S. R. M.; Nark, T. C., Jr.; O'Keefe, J. V.

1971-01-01

The development of the aircraft has progressed to the point where the design of the modifications to the de Havilland C-8A Buffalo is complete and the engines are being tested. The predicted performance shows that the aircraft will be able to take off and land in less than 1500 ft. Simulation studies indicate that the handling qualities of the aircraft, with stability augmentation, will be acceptable for STOL research missions. Special techniques were required, however, for flight path control and transition from cruise to landing configuration .

Progress in wet-coated organic light-emitting devices for lighting

NASA Astrophysics Data System (ADS)

Liu, Jie; Ye, Qing; Lewis, Larry N.; Duggal, Anil R.

2007-09-01

Here we present recent progress in developing efficient wet-coated organic light-emitting devices (OLEDs) for lighting applications. In particular, we describe a novel approach for building efficient wet-coated dye-doped blue phosphorescent devices. Further, a novel approach for achieving arbitrary emission patterning for OLEDs is discussed. This approach utilizes a photo-induced chemical doping strategy for selectively activating charge injection materials, thus enabling devices with arbitrary emission patterning. This approach may provide a simple, low cost path towards specialty lighting and signage applications for OLED technology.

Structural Analysis of the Right Rear Lug of American Airlines Flight 587

NASA Technical Reports Server (NTRS)

Raju, Ivatury S.; Glaessgen, Edward H.; Mason, Brian H.; Krishnamurthy, Thiagarajan; Davila, Carlos G.

2006-01-01

A detailed finite element analysis of the right rear lug of the American Airlines Flight 587 - Airbus A300-600R was performed as part of the National Transportation Safety Board s failure investigation of the accident that occurred on November 12, 2001. The loads experienced by the right rear lug are evaluated using global models of the vertical tail, local models near the right rear lug, and a global-local analysis procedure. The right rear lug was analyzed using two modeling approaches. In the first approach, solid-shell type modeling is used, and in the second approach, layered-shell type modeling is used. The solid-shell and the layered-shell modeling approaches were used in progressive failure analyses (PFA) to determine the load, mode, and location of failure in the right rear lug under loading representative of an Airbus certification test conducted in 1985 (the 1985-certification test). Both analyses were in excellent agreement with each other on the predicted failure loads, failure mode, and location of failure. The solid-shell type modeling was then used to analyze both a subcomponent test conducted by Airbus in 2003 (the 2003-subcomponent test) and the accident condition. Excellent agreement was observed between the analyses and the observed failures in both cases. The moment, Mx (moment about the fuselage longitudinal axis), has significant effect on the failure load of the lugs. Higher absolute values of Mx give lower failure loads. The predicted load, mode, and location of the failure of the 1985- certification test, 2003-subcomponent test, and the accident condition are in very good agreement. This agreement suggests that the 1985-certification and 2003-subcomponent tests represent the accident condition accurately. The failure mode of the right rear lug for the 1985-certification test, 2003-subcomponent test, and the accident load case is identified as a cleavage-type failure. For the accident case, the predicted failure load for the right rear lug from the PFA is greater than 1.98 times the limit load of the lugs.

Aspects of Synthetic Vision Display Systems and the Best Practices of the NASA's SVS Project

NASA Technical Reports Server (NTRS)

Bailey, Randall E.; Kramer, Lynda J.; Jones, Denise R.; Young, Steven D.; Arthur, Jarvis J.; Prinzel, Lawrence J.; Glaab, Louis J.; Harrah, Steven D.; Parrish, Russell V.

2008-01-01

NASA s Synthetic Vision Systems (SVS) Project conducted research aimed at eliminating visibility-induced errors and low visibility conditions as causal factors in civil aircraft accidents while enabling the operational benefits of clear day flight operations regardless of actual outside visibility. SVS takes advantage of many enabling technologies to achieve this capability including, for example, the Global Positioning System (GPS), data links, radar, imaging sensors, geospatial databases, advanced display media and three dimensional video graphics processors. Integration of these technologies to achieve the SVS concept provides pilots with high-integrity information that improves situational awareness with respect to terrain, obstacles, traffic, and flight path. This paper attempts to emphasize the system aspects of SVS - true systems, rather than just terrain on a flight display - and to document from an historical viewpoint many of the best practices that evolved during the SVS Project from the perspective of some of the NASA researchers most heavily involved in its execution. The Integrated SVS Concepts are envisagements of what production-grade Synthetic Vision systems might, or perhaps should, be in order to provide the desired functional capabilities that eliminate low visibility as a causal factor to accidents and enable clear-day operational benefits regardless of visibility conditions.

Conduction of Electrical Current to and Through the Human Body: A Review

PubMed Central

Fish, Raymond M.; Geddes, Leslie A.

2009-01-01

Objective: The objective of this article is to explain ways in which electric current is conducted to and through the human body and how this influences the nature of injuries. Methods: This multidisciplinary topic is explained by first reviewing electrical and pathophysiological principles. There are discussions of how electric current is conducted through the body via air, water, earth, and man-made conductive materials. There are also discussions of skin resistance (impedance), internal body resistance, current path through the body, the let-go phenomenon, skin breakdown, electrical stimulation of skeletal muscles and nerves, cardiac dysrhythmias and arrest, and electric shock drowning. After the review of basic principles, a number of clinically relevant examples of accident mechanisms and their medical effects are discussed. Topics related to high-voltage burns include ground faults, ground potential gradient, step and touch potentials, arcs, and lightning. Results: The practicing physician will have a better understanding of electrical mechanisms of injury and their expected clinical effects. Conclusions: There are a variety of types of electrical contact, each with important characteristics. Understanding how electric current reaches and travels through the body can help the clinician understand how and why specific accidents occur and what medical and surgical problems may be expected. PMID:19907637

Flight Simulator Evaluation of Synthetic Vision Display Concepts to Prevent Controlled Flight Into Terrain (CFIT)

NASA Technical Reports Server (NTRS)

Arthur, Jarvis J., III; Prinzel, Lawrence J., III; Kramer, Lynda J.; Parrish, Russell V.; Bailey, Randall E.

2004-01-01

In commercial aviation, over 30-percent of all fatal accidents worldwide are categorized as Controlled Flight Into Terrain (CFIT) accidents, where a fully functioning airplane is inadvertently flown into the ground. The major hypothesis for a simulation experiment conducted at NASA Langley Research Center was that a Primary Flight Display (PFD) with synthetic terrain will improve pilots ability to detect and avoid potential CFITs compared to conventional instrumentation. All display conditions, including the baseline, contained a Terrain Awareness and Warning System (TAWS) and Vertical Situation Display (VSD) enhanced Navigation Display (ND). Each pilot flew twenty-two approach departure maneuvers in Instrument Meteorological Conditions (IMC) to the terrain challenged Eagle County Regional Airport (EGE) in Colorado. For the final run, flight guidance cues were altered such that the departure path went into terrain. All pilots with a synthetic vision system (SVS) PFD (twelve of sixteen pilots) noticed and avoided the potential CFIT situation. The four pilots who flew the anomaly with the conventional baseline PFD configuration (which included a TAWS and VSD enhanced ND) had a CFIT event. Additionally, all the SVS display concepts enhanced the pilot s situational awareness, decreased workload and improved flight technical error (FTE) compared to the baseline configuration.

Space Shuttle Solid Rocket Booster Debris Assessment

NASA Technical Reports Server (NTRS)

Kendall, Kristin; Kanner, Howard; Yu, Weiping

2006-01-01

The Space Shuttle Columbia Accident revealed a fundamental problem of the Space Shuttle Program regarding debris. Prior to the tragedy, the Space Shuttle requirement stated that no debris should be liberated that would jeopardize the flight crew and/or mission success. When the accident investigation determined that a large piece of foam debris was the primary cause of the loss of the shuttle and crew, it became apparent that the risk and scope of - damage that could be caused by certain types of debris, especially - ice and foam, were not fully understood. There was no clear understanding of the materials that could become debris, the path the debris might take during flight, the structures the debris might impact or the damage the impact might cause. In addition to supporting the primary NASA and USA goal of returning the Space Shuttle to flight by understanding the SRB debris environment and capability to withstand that environment, the SRB debris assessment project was divided into four primary tasks that were required to be completed to support the RTF goal. These tasks were (1) debris environment definition, (2) impact testing, (3) model correlation and (4) hardware evaluation. Additionally, the project aligned with USA's corporate goals of safety, customer satisfaction, professional development and fiscal accountability.

Middle ear osteoma causing progressive facial nerve weakness: a case report.

PubMed

Curtis, Kate; Bance, Manohar; Carter, Michael; Hong, Paul

2014-09-18

Facial nerve weakness is most commonly due to Bell's palsy or cerebrovascular accidents. Rarely, middle ear tumor presents with facial nerve dysfunction. We report a very unusual case of middle ear osteoma in a 49-year-old Caucasian woman causing progressive facial nerve deficit. A subtle middle ear lesion was observed on otoscopy and computed tomographic images demonstrated an osseous middle ear tumor. Complete surgical excision resulted in the partial recovery of facial nerve function. Facial nerve dysfunction is rarely caused by middle ear tumors. The weakness is typically due to a compressive effect on the middle ear portion of the facial nerve. Early recognition is crucial since removal of these lesions may lead to the recuperation of facial nerve function.

A study of finite element modeling for simulation of vehicle rollover

NASA Astrophysics Data System (ADS)

Lin, Zhigui; Liu, Changye; Lv, Juncheng; Jia, Ligang; Sun, Haichao; Chen, Tao

2017-04-01

At present, the automobile ownership has been a very large figure, and growing rapidly with the social progress and development. Automobile has been one of the most important transportation in people's life. Accordingly, there are a large number of fatalities and serious injuries in traffic accident every year. Vehicle safety has been paid more and more attentions in recent years. There are several kinds of traffic accidents including frontal crash, side crash, etc., while rollover crash is a special kind. The vehicle rollover has the lowest incidence in the all kinds of traffic accidents but has the highest rate of seriously injuries, most of which lead to death. For these reasons, it is very necessary to study the vehicle rollover crash. However, it's so hard that there are a small amount of literatures studying rollover due to its variety, large degree of freedom, and difficulty to repeat and control. The method to investigate rollover crash contains experiment, the finite element method and rigid-body-based models. The finite element method contains many advantages such as low cost, repeatability, detailed data and so on, but the limitation is obvious. A test and simulation has been accomplished to study the FEM for vehicle rollover crash particularly in this paper.

MELCOR computer code manuals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summers, R.M.; Cole, R.K. Jr.; Smith, R.C.

1995-03-01

MELCOR is a fully integrated, engineering-level computer code that models the progression of severe accidents in light water reactor nuclear power plants. MELCOR is being developed at Sandia National Laboratories for the U.S. Nuclear Regulatory Commission as a second-generation plant risk assessment tool and the successor to the Source Term Code Package. A broad spectrum of severe accident phenomena in both boiling and pressurized water reactors is treated in MELCOR in a unified framework. These include: thermal-hydraulic response in the reactor coolant system, reactor cavity, containment, and confinement buildings; core heatup, degradation, and relocation; core-concrete attack; hydrogen production, transport, andmore » combustion; fission product release and transport; and the impact of engineered safety features on thermal-hydraulic and radionuclide behavior. Current uses of MELCOR include estimation of severe accident source terms and their sensitivities and uncertainties in a variety of applications. This publication of the MELCOR computer code manuals corresponds to MELCOR 1.8.3, released to users in August, 1994. Volume 1 contains a primer that describes MELCOR`s phenomenological scope, organization (by package), and documentation. The remainder of Volume 1 contains the MELCOR Users Guides, which provide the input instructions and guidelines for each package. Volume 2 contains the MELCOR Reference Manuals, which describe the phenomenological models that have been implemented in each package.« less

Chernobyl Studies Project: Working group 7.0, Environmental transport and health effects. Progress report, March--September 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anspaugh, L.R.; Hendrickson, S.M.

1994-12-01

In April 1988, the US and the former-USSR signed a Memorandum of Cooperation (MOC) for Civilian Nuclear Reactor Safety; this MOC was a direct result of the accident at the Chernobyl Nuclear Power Plant Unit 4 and the following efforts by the two countries to implement a joint program to improve the safety of nuclear power plants and to understand the implications of environmental releases. A Joint Coordinating Committee for Civilian Nuclear Reactor Safety (JCCCNRS) was formed to implement the MOC. The JCCCNRS established many working groups; most of these were the responsibility of the Nuclear Regulatory Commission, as farmore » as the US participation was concerned. The lone exception was Working Group 7 on Environmental Transport and Health Effects, for which the US participation was the responsibility of the US Department of Energy (DOE). The purpose of Working Group 7 was succintly stated to be, ``To develop jointly methods to project rapidly the health effects of any future nuclear reactor accident.`` To implement the work DOE then formed two subworking groups: 7.1 to address Environmental Transport and 7.2 to address Health Effects. Thus, the DOE-funded Chernobyl Studies Project began. The majority of the initial tasks for this project are completed or near completion. The focus is now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are currently working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, M. T.

The overall objective of the current work is to carry out a scoping analysis to determine the impact of ATF on late phase accident progression; in particular, the molten core-concrete interaction portion of the sequence that occurs after the core debris fails the reactor vessel and relocates into containment. This additional study augments previous work by including kinetic effects that govern chemical reaction rates during core-concrete interaction. The specific ATF considered as part of this study is SiC-clad UO 2.

[Preventing occupational eye trauma (Geneva, Switzerland)].

PubMed

Ngondi, C Emole; Chastonay, P; Dosso, A

2010-01-01

Occupational eye trauma causes injuries with often serious socioprofessional, medical-legal, and economic consequences, not only for workers themselves, but also for employers. In spite of today's legislation and the efforts to encourage prevention, the frequency of occupational ocular accidents remains relatively high despite how easy it is to protect the eyes. In this study, the reasons that these accidents persist despite the progress made in preventive measures was investigated. From January to July 2005, we analyzed the parameters related to 175 occupational eye injuries. All patients agreed to take part in this study, which was carried out in the emergency unit of the Ophthalmology Clinic at Geneva University Hospital. Additional data was collected in companies. Construction workers were the most exposed (41.1%). The activity with the greatest risk was grinding (19.4%). The most affected structure of the eye was the cornea (84%), 72.6% patients were not equipped with ocular protection at the time of the accident, and 17.4% wore poorly adapted eye protection. This can be explained by negligence, lack of awareness, etc. Overall, workers, employers, and the legislation in force are all responsible. Our results are comparable with those found in the literature, with certain particularities because heavy industry was underrepresented in our sample. Analysis of the law on the prevention of occupational accidents and diseases shows that the worker is not sufficiently aware of his responsibilities. To our knowledge, the legal aspects treated herein have not been studied. As done in certain studies, we emphasize the importance of preventive ophthalmologic examinations as well as improvement of both working conditions and worker awareness in the workplace. Primary prevention must be reinforced. Information campaigns within the workplace aimed at workers and revision of the laws on occupational safety are some of the recommendations that are proposed to control occupational ocular accidents. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

Channel movement of meandering Indiana streams

USGS Publications Warehouse

Daniel, James F.

1971-01-01

Because of the consistency of yearly above-average discharge volumes, it was possible to develop a general relation between path-length increase per thousand cubic-feet-per-second-days per square mile of drainage area above average discharge and the width-depth ratio of the channel. Little progress was made toward defining relationships for rotation and translation.

Women's Equality in the Workplace: Personal Comments of a Business Lawyer

ERIC Educational Resources Information Center

Baker, Ann G.

2016-01-01

In recent years, female enrollments have increased exponentially in many areas of higher education studies. Consequently, women are everywhere present in their chosen career paths, though too few arrive at top-level posts. However, the workplace (particularly the private sector) has not kept pace with this progress in terms of gender-sensitive…

Exploration of Individual Study Paths of Successful First-Year Students: An Interview Study

ERIC Educational Resources Information Center

Lindblom-Ylänne, Sari; Haarala-Muhonen, Anne; Postareff, Liisa; Hailikari, Telle

2017-01-01

The aim of the present study was to explore the individual profiles of successful, rapidly progressing first-year university students. The participants numbered 38 humanities and law students, who volunteered to be interviewed. The interview data were analysed using abductive content analysis. Two student profiles were distinguished:…

Tenure Tensions: Out in the Enchanted Forest

ERIC Educational Resources Information Center

Tyler, Jo A.

2010-01-01

The tenure track in higher education represents a path shrouded in a fair degree of mystery. This essay provides the perspective of a middle-aged, second-career tenure track faculty member on the vagaries of progressing down the track as an out lesbian. Three dialectics that build tension into the process--covering-creating, evaluation-liberation,…

Reaping the Benefits of Parent Education

ERIC Educational Resources Information Center

Haakmat, Martha

2015-01-01

Martha Haakmat writes in this article that in some ways she understands why parents might have a harder time understanding why Montessori is education at its best, especially as their children progress past preschool. Haakmat goes on to say that the learning path at Montessori schools is more proactive. Montessori schools ask that parents partner…

Achieving Sustainability through Targeted Curriculum Change. Strategies for Transformative Change

ERIC Educational Resources Information Center

Audant, B.; Kirby, C.

2016-01-01

Integrated academic skills instruction was one of the core elements of the CareerPATH consortium that provided math, reading, writing, and English language skills instruction "contextualized" to occupational training. Its goal was to engage adult learners and accelerate their progress in college and careers. The focus of this brief is…

The effects of progressing and nonprogressing Mycobacterium avium ssp. paratuberculosis infection on milk production in dairy cows

USDA-ARS?s Scientific Manuscript database

Longitudinal data from three commercial dairy herds in the northeast United States, collected from 2004 to 2011, were analyzed to determine the effect of Johne’s disease status and path on milk production. Disease status, as indicated by Mycobacterium avium subsp. paratuberculosis test results, was ...

Integration of an Intelligent Tutoring System in a Course of Computer Network Design

ERIC Educational Resources Information Center

Verdú, Elena; Regueras, Luisa M.; Gal, Eran; de Castro, Juan P.; Verdú, María J.; Kohen-Vacs, Dan

2017-01-01

INTUITEL is a research project aiming to offer a personalized learning environment. The INTUITEL approach includes an Intelligent Tutoring System that gives students recommendations and feedback about what the best learning path is for them according to their profile, learning progress, context and environmental influences. INTUITEL combines…

Histories of Colorism and Implications for Education

ERIC Educational Resources Information Center

Keith, Verna M.; Monroe, Carla R.

2016-01-01

In this article, we consider how colorist ideologies and practices unsettle arguments that celebrate racial gains in education, particularly as related to divides that have narrowed since the Civil Rights Movement of the 1950s and 1960s. Although outcomes based on race may document some general paths of improvement, progress and success can be…

Paving the Path to Success. Data for Action 2014. Summary

ERIC Educational Resources Information Center

Data Quality Campaign, 2014

2014-01-01

At the federal level, leaders can promote policies that reduce burdens on states, encourage collaboration across agencies, and help build the capacity of stakeholders to use data while ensuring the privacy of student information. The annual "Data for Action" survey measures states' progress toward achieving the 10 State Actions to Ensure…

Balancing the Equation: Do Course Variations in Algebra 1 Provide Equal Student Outcomes?

ERIC Educational Resources Information Center

Kenfield, Danielle M.

2013-01-01

Historically, algebra has served as a gatekeeper that divides students into academic programs with varying opportunities to learn and controls access to higher education and career opportunities. Successful completion of Algebra 1 demonstrates mathematical proficiency and allows access to a sequential and progressive path of advanced study that…

Clinical Trials Offer a Path to Better Care for AYAs with Cancer

Cancer.gov

The slow progress against adolescent and young adult cancers is due, in part, to this populations lack of participation in clinical trials. Researchers are testing innovative ways to enroll more AYAs in clinical trials—using expanded access, patient navigation, community outreach, and collaborations between academic and community doctors.

The Employment Retention and Advancement Project: Paths to Advancement for Single Parents

ERIC Educational Resources Information Center

Miller, Cynthia; Deitch, Victoria; Hill, Aaron

2010-01-01

Between 2000 and 2003, the Employment Retention and Advancement (ERA) project identified and implemented a diverse set of innovative models designed to promote employment stability and wage or earnings progression among low-income individuals, mostly current or former welfare recipients. The project's goal was to determine which strategies could…

The Employment Retention and Advancement Project: Paths to Advancement for Single Parents. Executive Summary

ERIC Educational Resources Information Center

Miller, Cynthia; Deitch, Victoria; Hill, Aaron

2010-01-01

Between 2000 and 2003, the Employment Retention and Advancement (ERA) project identified and implemented a diverse set of innovative models designed to promote employment stability and wage or earnings progression among low-income individuals, mostly current or former welfare recipients. The project's goal was to determine which strategies could…

Reaction chemistry in rechargeable Li-O2 batteries.

PubMed

Lim, Hee-Dae; Lee, Byungju; Bae, Youngjoon; Park, Hyeokjun; Ko, Youngmin; Kim, Haegyeom; Kim, Jinsoo; Kang, Kisuk

2017-05-22

The seemingly simple reaction of Li-O 2 batteries involving lithium and oxygen makes this chemistry attractive for high-energy-density storage systems; however, achieving this reaction in practical rechargeable Li-O 2 batteries has proven difficult. The reaction paths leading to the final Li 2 O 2 discharge products can be greatly affected by the operating conditions or environment, which often results in major side reactions. Recent research findings have begun to reveal how the reaction paths may be affected by the surrounding conditions and to uncover the factors contributing to the difficulty in achieving the reactions of lithium and oxygen. This progress report describes the current state of understanding of the electrode reaction mechanisms in Li-O 2 batteries; the factors that affect reaction pathways; and the effect of cell components such as solvents, salts, additives, and catalysts on the discharge product and its decomposition during charging. This comprehensive review of the recent progress in understanding the reaction chemistry of the Li-O 2 system will serve as guidelines for future research and aid in the development of reliable high-energy-density rechargeable Li-O 2 batteries.

The role of Fenton reaction in ROS-induced toxicity underlying atherosclerosis - modeled and analyzed using a Petri net-based approach.

PubMed

Formanowicz, Dorota; Radom, Marcin; Rybarczyk, Agnieszka; Formanowicz, Piotr

2018-03-01

The superoxide-driven Fenton reaction plays an important role in the transformation of poorly reactive radicals into highly reactive ones. These highly reactive species (ROS), especially hydroxyl radicals can lead to many disturbances contributing to the endothelial dysfunction being a starting point for atherosclerosis. Although, iron has been identified as a possible culprit influencing formation of ROS, its significance in this process is still debatable. To better understand this phenomenon, the influence of blockade of Fenton reaction in a proposed Petri net-based model of the selected aspects of the iron ROS-induced toxicity in atherosclerosis has been evaluated. As a result of the blockade of iron ions formation in the model, even up to 70% of the paths leading to the progression of atherosclerosis in this model has been blocked. In addition, after adding to the model, the blockade of the lipids peroxidation paths, progression of atherosclerotic plaque has been not observed. This allowed to conclude that the superoxide-driven Fenton reaction plays a significant role in the atherosclerosis. Copyright © 2018 Elsevier B.V. All rights reserved.

Deep dysphasic performance in non-fluent progressive aphasia: a case study.

PubMed

Tree, J J; Perfect, T J; Hirsh, K W; Copstick, S

2001-01-01

We present a patient (PW) with non-fluent progressive aphasia, characterized by severe word finding difficulties and frequent phonemic paraphasias in spontaneous speech. It has been suggested that such patients have insufficient access to phonological information for output and cannot construct the appropriate sequence of selected phonemes for articulation. Consistent with such a proposal, we found that PW was impaired on a variety of verbal tasks that demand access to phonological representations (reading, repetition, confrontational naming and rhyme judgement); she also demonstrated poor performance on syntactic and grammatical processing tasks. However, examination of PW's repetition performance also revealed that she made semantic paraphasias and that her performance was influenced by imageability and lexical status. Her auditory-verbal short-term memory was also severely compromised. These features are consistent with 'deep dysphasia', a disorder reported in patients suffering from stroke or cerebrovascular accident, and rarely reported in the context of non-fluent progressive aphasia. PW's pattern of performance is evaluated in terms of current models of both non-fluent progressive aphasia and deep dysphasia.

Barriers and constraints: women physicists' perceptions of career progress

NASA Astrophysics Data System (ADS)

Hodgson, Barbara; Scanlon, Eileen; Whitelegg, Elizabeth

2000-11-01

Researchers in the area of women in science are trying to understand how the participation of women in science can be increased and also what prevents women from developing scientific careers. Past influential work supports the importance of taking the perspective of women's education and career paths as a whole, emphasizing the importance of structural and social factors in career progress. This paper reports some outcomes from an interview study with women PhD physicists working in a variety of science-related careers. Our aim is to explore and document the career experience of women scientists and to identify barriers and constraints to women's participation in science careers and to investigate ways in which educational experiences contribute to career progress.

Cognitive and psychological reactions of the general population three months after the 2011 Tohoku earthquake and tsunami.

PubMed

Kyutoku, Yasushi; Tada, Ryoko; Umeyama, Takahiko; Harada, Kenji; Kikuchi, Senichiro; Watanabe, Eiju; Liegey-Dougall, Angela; Dan, Ippeita

2012-01-01

The largest earthquake on record in Japan (magnitude 9.0) occurred on March 11, 2011, and the subsequent tsunami devastated the Pacific coast of Northern Japan. These further triggered the Fukushima I nuclear power plant accidents. Such a hugely complex disaster inevitably has negative psychological effects on general populations as well as on the direct victims. While previous disaster studies enrolled descriptive approaches focusing on direct victims, the structure of the psychological adjustment process of people from the general population has remained uncertain. The current study attempted to establish a path model that sufficiently reflects the early psychological adaptation process of the general population to large-scale natural disasters. Participants from the primary disaster area (n = 1083) and other areas (n = 2372) voluntarily participated in an online questionnaire study. By constructing path models using a structural equation model procedure (SEM), we examined the structural relationship among psychological constructs known related to disasters. As post-traumatic stress symptoms (PTS) were significantly more present in people in the primarily affected area than in those in secondary- or non-affected areas, the path models were constructed for the primary victims. The parsimoniously depicted model with the best fit was achieved for the psychological-adjustment centered model with quality of life (QoL) as a final outcome. The paths to QoL via negative routes (from negative cognitive appraisal, PTS, and general stress) were dominant, suggesting the importance of clinical intervention for reducing negative cognitive appraisal, and for caring for general stress and PTS to maintain QoL at an early stage of psychological adaptation to a disaster. The model also depicted the presence of a positive route where positive cognitive appraisal facilitates post-traumatic growth (PTG) to achieve a higher QoL, suggesting the potential importance of positive psychological preventive care for unexpected natural disasters.

Cognitive and Psychological Reactions of the General Population Three Months After the 2011 Tohoku Earthquake and Tsunami

PubMed Central

Kyutoku, Yasushi; Tada, Ryoko; Umeyama, Takahiko; Harada, Kenji; Kikuchi, Senichiro; Watanabe, Eiju; Liegey-Dougall, Angela; Dan, Ippeita

2012-01-01

Background The largest earthquake on record in Japan (magnitude 9.0) occurred on March 11, 2011, and the subsequent tsunami devastated the Pacific coast of Northern Japan. These further triggered the Fukushima I nuclear power plant accidents. Such a hugely complex disaster inevitably has negative psychological effects on general populations as well as on the direct victims. While previous disaster studies enrolled descriptive approaches focusing on direct victims, the structure of the psychological adjustment process of people from the general population has remained uncertain. The current study attempted to establish a path model that sufficiently reflects the early psychological adaptation process of the general population to large-scale natural disasters. Methods and Findings Participants from the primary disaster area (n = 1083) and other areas (n = 2372) voluntarily participated in an online questionnaire study. By constructing path models using a structural equation model procedure (SEM), we examined the structural relationship among psychological constructs known related to disasters. As post-traumatic stress symptoms (PTS) were significantly more present in people in the primarily affected area than in those in secondary- or non-affected areas, the path models were constructed for the primary victims. The parsimoniously depicted model with the best fit was achieved for the psychological-adjustment centered model with quality of life (QoL) as a final outcome. Conclusion The paths to QoL via negative routes (from negative cognitive appraisal, PTS, and general stress) were dominant, suggesting the importance of clinical intervention for reducing negative cognitive appraisal, and for caring for general stress and PTS to maintain QoL at an early stage of psychological adaptation to a disaster. The model also depicted the presence of a positive route where positive cognitive appraisal facilitates post-traumatic growth (PTG) to achieve a higher QoL, suggesting the potential importance of positive psychological preventive care for unexpected natural disasters. PMID:22347421

Sense and avoid technologies with applications to unmanned aircraft systems: Review and prospects

NASA Astrophysics Data System (ADS)

Yu, Xiang; Zhang, Youmin

2015-04-01

Unmanned Aircraft Systems (UASs) are becoming ever more promising over the last decade. The Sense and Avoid (S&A) system plays a profoundly important role in integrating UASs into the National Airspace System (NAS) with reliable and safe operations. After analyzing the manner of S&A system, this paper systematically presents an overview on the recent progress in S&A technologies in the sequence of fundamental functions/components of S&A in sensing techniques, decision making, path planning, and path following. The approaches to these four aspects are outlined and summarized, based on which the existing challenges and potential solutions are highlighted for facilitating the development of S&A systems.

Behavior of a nuclear steel containment equipment hatch at large strain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fanous, F.; Greimann, L.

1988-05-01

During a severe accident, buckling of a steel containment hatch door, large deformation and ovaling of the hatch sleeve are potential causes of mismatch at the sealing surface which can result in a leakage path. A three-dimensional nonlinear finite element analysis of a typical steel containment/sleeve/hatch assembly that includes containment stiffeners, pretensioned swing bolts, and hatch door geometric imperfection is presented. The analysis was carried out to the nonlinear range up to large strains. The results indicated that the buckling load occurs at pressure, far above that which causes gross yielding of the shell plate. Although buckling of the hatchmore » door increased the relative motions of the hatch sleeve and the hatch door, the motions remained sufficiently small to prevent leakage.« less

High Temperature Chemistry in the Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Jacobson, Nathan; Opila, Elizabeth; Tallant, David; Simpson, Regina

2004-01-01

Initial estimates on the temperature and conditions of the breach in Columbia's wing focused on analyses of the slag deposits. These deposits are complex mixtures of the reinforced carbon/carbon (RCC) constituents, insulation material, and wing structural materials. However it was possible to clearly discern melted/solidified Cerachrome(R) insulation, indicating the temperatures had exceeded 1760 C. Current research focuses on the carbon/carbon in the path from the breach. Carbon morphology indicates heavy oxidation and erosion. Raman spectroscopy yielded further temperature estimates. A technique developed at Sandia National Laboratories is based on crystallite size in carbon chars. Lower temperatures yield nanocrystalline graphite; whereas higher temperatures yield larger graphite crystals. By comparison to standards the temperatures on the recovered RCC fragments were estimated to have been greater than 2700 C.

Synthetic and Enhanced Vision System for Altair Lunar Lander

NASA Technical Reports Server (NTRS)

Prinzell, Lawrence J., III; Kramer, Lynda J.; Norman, Robert M.; Arthur, Jarvis J., III; Williams, Steven P.; Shelton, Kevin J.; Bailey, Randall E.

2009-01-01

Past research has demonstrated the substantial potential of synthetic and enhanced vision (SV, EV) for aviation (e.g., Prinzel & Wickens, 2009). These augmented visual-based technologies have been shown to significantly enhance situation awareness, reduce workload, enhance aviation safety (e.g., reduced propensity for controlled flight -into-terrain accidents/incidents), and promote flight path control precision. The issues that drove the design and development of synthetic and enhanced vision have commonalities to other application domains; most notably, during entry, descent, and landing on the moon and other planetary surfaces. NASA has extended SV/EV technology for use in planetary exploration vehicles, such as the Altair Lunar Lander. This paper describes an Altair Lunar Lander SV/EV concept and associated research demonstrating the safety benefits of these technologies.

The Application of Electron Microscopy Techniques to the Space Shuttle Columbia Accident Investigation

NASA Technical Reports Server (NTRS)

Shah, Sandeep; Jerman, Greg

2005-01-01

The Space Shuttle Columbia was returning from a 16-day research mission, STS- 107, with nominal system performance prior to the beginning of the entry interface into earth's upper atmosphere. Approximately one minute and twenty four seconds into the peak heating region of the entry interface, an off-nominal temperature rise was observed in the left main landing gear brake line. Nearly seven minutes later, all contact was lost with Columbia. Debris was observed periodically exiting the Shuttle's flight path throughout the reentry profile over California, Nevada, and New Mexico, until its final breakup over Texas. During the subsequent investigation, electron microscopy techniques were crucial in revealing the location of the fatal damage that resulted in the loss of Columbia and her crew.

Addison's disease.

PubMed

Sarkar, Soumya Brata; Sarkar, Subrata; Ghosh, Supratim; Bandyopadhyay, Subhankar

2012-10-01

Addison's disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison's disease. Classically, hyperpigmentation is associated with the disease, and intraoral pigmentation is perceived as the initial sign and develops earlier than the dermatological pigmentation. The symptoms of the disease usually progress slowly and an event of illness or accident can make the condition worse and may lead to a life-threatening crisis. In this case, several oral as well as systemic manifestation of the Addison's disease was encountered.

Addison's disease

PubMed Central

Sarkar, Soumya Brata; Sarkar, Subrata; Ghosh, Supratim; Bandyopadhyay, Subhankar

2012-01-01

Addison's disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison's disease. Classically, hyperpigmentation is associated with the disease, and intraoral pigmentation is perceived as the initial sign and develops earlier than the dermatological pigmentation. The symptoms of the disease usually progress slowly and an event of illness or accident can make the condition worse and may lead to a life-threatening crisis. In this case, several oral as well as systemic manifestation of the Addison's disease was encountered. PMID:23633816

United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

DTIC Science & Technology

2013-09-01

hreatens the well being of our community, whether through noi se and emissions or the risk of accidents from an under- test ed and flawed design . The...such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...appear in the report, e.g. 001; AFAPL30480105. 6. AUTHOR(S). Enter name(s) of person(s) responsible for writing the report, performing the research

The path towards sustainable energy

NASA Astrophysics Data System (ADS)

Chu, Steven; Cui, Yi; Liu, Nian

2017-01-01

Civilization continues to be transformed by our ability to harness energy beyond human and animal power. A series of industrial and agricultural revolutions have allowed an increasing fraction of the world population to heat and light their homes, fertilize and irrigate their crops, connect to one another and travel around the world. All of this progress is fuelled by our ability to find, extract and use energy with ever increasing dexterity. Research in materials science is contributing to progress towards a sustainable future based on clean energy generation, transmission and distribution, the storage of electrical and chemical energy, energy efficiency, and better energy management systems.

The path towards sustainable energy.

PubMed

Chu, Steven; Cui, Yi; Liu, Nian

2016-12-20

Civilization continues to be transformed by our ability to harness energy beyond human and animal power. A series of industrial and agricultural revolutions have allowed an increasing fraction of the world population to heat and light their homes, fertilize and irrigate their crops, connect to one another and travel around the world. All of this progress is fuelled by our ability to find, extract and use energy with ever increasing dexterity. Research in materials science is contributing to progress towards a sustainable future based on clean energy generation, transmission and distribution, the storage of electrical and chemical energy, energy efficiency, and better energy management systems.

A study of methods to predict and measure the transmission of sound through the walls of light aircraft

NASA Technical Reports Server (NTRS)

Bernhard, R. J.; Bolton, J. S.

1988-01-01

The objectives are: measurement of dynamic properties of acoustical foams and incorporation of these properties in models governing three-dimensional wave propagation in foams; tests to measure sound transmission paths in the HP137 Jetstream 3; and formulation of a finite element energy model. In addition, the effort to develop a numerical/empirical noise source identification technique was completed. The investigation of a design optimization technique for active noise control was also completed. Monthly progress reports which detail the progress made toward each of the objectives are summarized.

[Not Available].

PubMed

Yanashima, Ryoji; Kitagawa, Noriyuki; Matsubara, Yoshiya; Weatheritt, Robert; Oka, Kotaro; Kikuchi, Shinichi; Tomita, Masaru; Ishizaki, Shun

2009-01-01

The scale-free and small-world network models reflect the functional units of networks. However, when we investigated the network properties of a signaling pathway using these models, no significant differences were found between the original undirected graphs and the graphs in which inactive proteins were eliminated from the gene expression data. We analyzed signaling networks by focusing on those pathways that best reflected cellular function. Therefore, our analysis of pathways started from the ligands and progressed to transcription factors and cytoskeletal proteins. We employed the Python module to assess the target network. This involved comparing the original and restricted signaling cascades as a directed graph using microarray gene expression profiles of late onset Alzheimer's disease. The most commonly used method of shortest-path analysis neglects to consider the influences of alternative pathways that can affect the activation of transcription factors or cytoskeletal proteins. We therefore introduced included k-shortest paths and k-cycles in our network analysis using the Python modules, which allowed us to attain a reasonable computational time and identify k-shortest paths. This technique reflected results found in vivo and identified pathways not found when shortest path or degree analysis was applied. Our module enabled us to comprehensively analyse the characteristics of biomolecular networks and also enabled analysis of the effects of diseases considering the feedback loop and feedforward loop control structures as an alternative path.

ICT Is Not Participation Is Not Democracy - eParticipation Development Models Revisited

NASA Astrophysics Data System (ADS)

Grönlund, Åke

There exist several models to describe “progress” in eParticipation. Models are typically ladder type and share two assumptions; progress is equalled with more sophisticated use of technology, and direct democracy is seen as the most advanced democracy model. None of the assumptions are true, considering democratic theory, and neither is fruitful as the simplification disturbs analysis and hence obscures actual progress made. The models convey a false impression of progress, but neither the goal, nor the path or the stakeholders driving the development are clearly understood, presented or evidenced. This paper analyses commonly used models based on democratic theory and eParticipation practice, and concludes that all are biased and fail to distinguish between the three dimensions an eParticipation progress model must include; relevance to democracy by any definition, applicability to different processes, (capacity building as well as decision making), and measuring different levels of participation without direct democracy bias.

Design of An 18 MW Beam Dump for 500 GeV Electron/Positron Beams at An ILC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amann, John; /SLAC; Arnold, Ray

This article presents a report on the progress made in designing 18 MW water based Beam Dumps for electrons or positrons for an International Linear Collider (ILC). Multi-dimensional technology issues have to be addressed for the successful design of the Beam Dump. They include calculations of power deposition by the high energy electron/positron beam bunch trains, computational fluid dynamic analysis of turbulent water flow, mechanical design, process flow analysis, hydrogen/oxygen recombiners, handling of radioactive 7Be and 3H, design of auxiliary equipment, provisions for accident scenarios, remote window exchanger, radiation shielding, etc. The progress made to date is summarized, the currentmore » status, and also the issues still to be addressed.« less

A Novel Anti-Beta2-Microglobulin Antibody Inhibition of Androgen Receptor Expression, Survival, and Progression in Prostate Cancer Cells

DTIC Science & Technology

2009-05-31

Konaka H, Sodek J, Zhau HE, Chung LW. Human Osteocalcin and Bone Sialoprotein Mediating Osteomimicry of Prostate Cancer Cells: Role of cAMP... sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling path- way. Cancer Res 2005;65:2303^13

Cosmic ray astroparticle physics: current status and future perspectives

NASA Astrophysics Data System (ADS)

Donato, Fiorenza

2017-02-01

The data we are receiving from galactic cosmic rays are reaching an unprecedented precision, over very wide energy ranges. Nevertheless, many problems are still open, while new ones seem to appear when data happen to be redundant. We will discuss some paths to possible progress in the theoretical modeling and experimental exploration of the galactic cosmic radiation.

Food Business Entrepreneurship

NASA Astrophysics Data System (ADS)

Weber, Peter

Though not a very traditional career path for food scientists, one option is to go into business for yourself by starting a food business. Food business entrepreneurship is a difficult career that entails long work hours, extensive decision making, and tasks that require knowledge beyond food science. However, there is high potential for rewards, including financial rewards, career progression, and personal flexibility.

Race for Results: Building a Path to Opportunity for All Children

ERIC Educational Resources Information Center

Annie E. Casey Foundation, 2014

2014-01-01

In this policy report, the Annie E. Casey Foundation explores the intersection of kids, race, and opportunity. The report features the new Race for Results index, which compares how children are progressing on key milestones across racial and ethnic groups at the national and state level. The index is based on 12 indicators that measure a…

The Reality of "New" Careers for Men and for Women

ERIC Educational Resources Information Center

Ackah, Carol; Heaton, Norma

2004-01-01

The research for this paper focused on the career paths and career progression of men and women in management occupations. The study set out to explore the extent to which the traditional career has been replaced by the so-called "boundaryless" career. In particular it sought to establish whether such new career patterns have been more…

Markov Model of Accident Progression at Fukushima Daiichi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuadra A.; Bari R.; Cheng, L-Y

2012-11-11

On March 11, 2011, a magnitude 9.0 earthquake followed by a tsunami caused loss of offsite power and disabled the emergency diesel generators, leading to a prolonged station blackout at the Fukushima Daiichi site. After successful reactor trip for all operating reactors, the inability to remove decay heat over an extended period led to boil-off of the water inventory and fuel uncovery in Units 1-3. A significant amount of metal-water reaction occurred, as evidenced by the quantities of hydrogen generated that led to hydrogen explosions in the auxiliary buildings of the Units 1 & 3, and in the de-fuelled Unitmore » 4. Although it was assumed that extensive fuel damage, including fuel melting, slumping, and relocation was likely to have occurred in the core of the affected reactors, the status of the fuel, vessel, and drywell was uncertain. To understand the possible evolution of the accident conditions at Fukushima Daiichi, a Markov model of the likely state of one of the reactors was constructed and executed under different assumptions regarding system performance and reliability. The Markov approach was selected for several reasons: It is a probabilistic model that provides flexibility in scenario construction and incorporates time dependence of different model states. It also readily allows for sensitivity and uncertainty analyses of different failure and repair rates of cooling systems. While the analysis was motivated by a need to gain insight on the course of events for the damaged units at Fukushima Daiichi, the work reported here provides a more general analytical basis for studying and evaluating severe accident evolution over extended periods of time. This work was performed at the request of the U.S. Department of Energy to explore 'what-if' scenarios in the immediate aftermath of the accidents.« less

[Upper limb work-related musculoskeletal disorders (UL-WMSDs) in a large factory of the upholstered furniture industry: risk management].

PubMed

Nicoletti, S; Castoro, V; Iacobellis, M; Loizzo, N; Monopoli, L

2008-01-01

The industrial production of upholstered furniture exposes workers to significant risk of occupational disorders due to ergonomics-related problems, such as repetitive strain and movements of the upper limb, manual load lifting, prolonged static postures. This paper describes the main measures taken by the biggest company in the "sofa sector" in southern Italy in order to solve such problems in the years 1996-2004. the classic instruments of ergonomics were used such as risk assessment, medical surveillance, training and information programmes, technological reorganization of the manufacturing process and of single working tasks. The accident rate (number of accidents per million working hours) which showed an increasing trend in the previous years, rose from a value of 31 in 1996 to 51 in the years 1999-2000 (with a percentage of accidents related to load lifting in the range 25-35%). At the same time the incidence rate of work-related upper limb musculoskeletal disorders (UL-WMSDs) in the population of workers (which had increased in the meantime from 2500 to 3500 employees) reached nearly 5% in 2001, with peaks of 8-9% in the work tasks with higher exposure. Accident rates progressively fell in the following three years until a value of 20 was reached in 2004 and 2005, while the mean incidence rate of WMSDs reached a value of nearly 1%. The data need to be compared with the trends in the other companies of the sector in the same period, with an average incidence rate of WMSDs around 2% and a generally increasing trend. Ergonomic interventions not only concur in the management and control of negative events for workers health but also in achieving advantages in terms of lower costs and greater productivity.

Delayed-onset post-traumatic headache after a motor vehicle collision: a case report

PubMed Central

Stupar, Maja; Kim, Peter SY

2007-01-01

Introduction Headaches are common after a motor vehicle accident (MVA). Post-traumatic headaches share many clinical symptoms including the clinical course of primary headaches. Secondary headaches (including those resulting from a subdural hematoma) are not as common, but should be considered in cases of post-traumatic events particularly if clinical symptoms progress. Clinical Features A case of a patient with a post-traumatic subdural hematoma demonstrates the importance of carefully examining, properly diagnosing and managing patients that experience headaches after MVAs. This patient presented with uncomplicated low back pain, neck pain and headache which progressed at one month to include focal neurological deficits. Since clinical examination alone may not be sufficient to diagnose secondary headaches, immediate referral to the emergency department may be required. Conclusion Primary contact practitioners should be aware of the various causes of headaches that result after a MVA. Headaches, which do not respond or progress, should be followed aggressively to determine their source. PMID:17657301

Symbology Development for General Aviation Synthetic Vision Primary Flight Displays for the Approach and Missed-Approach Modes of Flight

NASA Technical Reports Server (NTRS)

Bartolone, Anthony P.; Hughes, Monica F.; Wong, Douglas T.; Takallu, Mohammad A.

2004-01-01

Spatial disorientation induced by inadvertent flight into instrument meteorological conditions (IMC) continues to be a leading cause of fatal accidents in general aviation. The Synthetic Vision Systems General Aviation (SVS-GA) research element, an integral part of NASA s Aviation Safety and Security Program (AvSSP), is investigating a revolutionary display technology designed to mitigate low visibility events such as controlled flight into terrain (CFIT) and low-visibility loss of control (LVLoC). The integrated SVS Primary Flight Display (SVS-PFD) utilizes computer generated 3-dimensional imagery of the surrounding terrain augmented with flight path guidance symbology. This unique combination will provide GA pilots with an accurate representation of their environment and projection of their flight path, regardless of time of day or out-the-window (OTW) visibility. The initial Symbology Development for Head-Down Displays (SD-HDD) simulation experiment examined 16 display configurations on a centrally located high-resolution PFD installed in NASA s General Aviation Work Station (GAWS) flight simulator. The results of the experiment indicate that situation awareness (SA) can be enhanced without having a negative impact on flight technical error (FTE), by providing a general aviation pilot with an integrated SVS display to use when OTW visibility is obscured.

Advanced Pathway Guidance Evaluations on a Synthetic Vision Head-Up Display

NASA Technical Reports Server (NTRS)

Kramer, Lynda J.; Prinzel, Lawrence J., III; Arthur, Jarvis J., III; Bailey, Randall E.

2005-01-01

NASA's Synthetic Vision Systems (SVS) project is developing technologies with practical applications to potentially eliminate low visibility conditions as a causal factor to civil aircraft accidents while replicating the operational benefits of clear day flight operations, regardless of the actual outside visibility condition. A major thrust of the SVS project involves the development/demonstration of affordable, certifiable display configurations that provide intuitive out-the-window terrain and obstacle information with advanced guidance for commercial and business aircraft. This experiment evaluated the influence of different pathway and guidance display concepts upon pilot situation awareness (SA), mental workload, and flight path tracking performance for Synthetic Vision display concepts using a Head-Up Display (HUD). Two pathway formats (dynamic and minimal tunnel presentations) were evaluated against a baseline condition (no tunnel) during simulated instrument meteorological conditions approaches to Reno-Tahoe International airport. Two guidance cues (tadpole, follow-me aircraft) were also evaluated to assess their influence. Results indicated that the presence of a tunnel on an SVS HUD had no effect on flight path performance but that it did have significant effects on pilot SA and mental workload. The dynamic tunnel concept with the follow-me aircraft guidance symbol produced the lowest workload and provided the highest SA among the tunnel concepts evaluated.

Pathway Design Effects on Synthetic Vision Head-Up Displays

NASA Technical Reports Server (NTRS)

Kramer, Lynda J.; Prinzel, Lawrence J., III; Arthur, Jarvis J., III; Bailey, Randall E.

2004-01-01

NASA s Synthetic Vision Systems (SVS) project is developing technologies with practical applications that will eliminate low visibility conditions as a causal factor to civil aircraft accidents while replicating the operational benefits of clear day flight operations, regardless of the actual outside visibility condition. A major thrust of the SVS project involves the development/demonstration of affordable, certifiable display configurations that provide intuitive out-the-window terrain and obstacle information with advanced pathway guidance for transport aircraft. This experiment evaluated the influence of different tunnel and guidance concepts upon pilot situation awareness (SA), mental workload, and flight path tracking performance for Synthetic Vision display concepts using a Head-Up Display (HUD). Two tunnel formats (dynamic, minimal) were evaluated against a baseline condition (no tunnel) during simulated IMC approaches to Reno-Tahoe International airport. Two guidance cues (tadpole, follow-me aircraft) were also evaluated to assess their influence on the tunnel formats. Results indicated that the presence of a tunnel on an SVS HUD had no effect on flight path performance but that it did have significant effects on pilot SA and mental workload. The dynamic tunnel concept with the follow-me aircraft guidance symbol produced the lowest workload and provided the highest SA among the tunnel concepts evaluated.

Modeling of Individual and Organizational Factors Affecting Traumatic Occupational Injuries Based on the Structural Equation Modeling: A Case Study in Large Construction Industries

PubMed Central

Mohammadfam, Iraj; Soltanzadeh, Ahmad; Moghimbeigi, Abbas; Akbarzadeh, Mehdi

2016-01-01

Background Individual and organizational factors are the factors influencing traumatic occupational injuries. Objectives The aim of the present study was the short path analysis of the severity of occupational injuries based on individual and organizational factors. Materials and Methods The present cross-sectional analytical study was implemented on traumatic occupational injuries within a ten-year timeframe in 13 large Iranian construction industries. Modeling and data analysis were done using the structural equation modeling (SEM) approach and the IBM SPSS AMOS statistical software version 22.0, respectively. Results The mean age and working experience of the injured workers were 28.03 ± 5.33 and 4.53 ± 3.82 years, respectively. The portions of construction and installation activities of traumatic occupational injuries were 64.4% and 18.1%, respectively. The SEM findings showed that the individual, organizational and accident type factors significantly were considered as effective factors on occupational injuries’ severity (P < 0.05). Conclusions Path analysis of occupational injuries based on the SEM reveals that individual and organizational factors and their indicator variables are very influential on the severity of traumatic occupational injuries. So, these should be considered to reduce occupational accidents’ severity in large construction industries. PMID:27800465

Regulatory Concerns on the In-Containment Water Storage System of the Korean Next Generation Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahn, Hyung-Joon; Lee, Jae-Hun; Bang, Young-Seok

2002-07-15

The in-containment water storage system (IWSS) is a newly adopted system in the design of the Korean Next Generation Reactor (KNGR). It consists of the in-containment refueling water storage tank, holdup volume tank, and cavity flooding system (CFS). The IWSS has the function of steam condensation and heat sink for the steam release from the pressurizer and provides cooling water to the safety injection system and containment spray system in an accident condition and to the CFS in a severe accident condition. With the progress of the KNGR design, the Korea Institute of Nuclear Safety has been developing Safety andmore » Regulatory Requirements and Guidances for safety review of the KNGR. In this paper, regarding the IWSS of the KNGR, the major contents of the General Safety Criteria, Specific Safety Requirements, Safety Regulatory Guides, and Safety Review Procedures were introduced, and the safety review items that have to be reviewed in-depth from the regulatory viewpoint were also identified.« less

Oxidative status assessment of the endemic bivalve Pinna nobilis affected by the oil spill from the sinking of the Don Pedro.

PubMed

Capó, Xavier; Tejada, Silvia; Box, Antonio; Deudero, Salud; Sureda, Antoni

2015-09-01

Several biomarkers were determined to evaluate the effects of the Don Pedro spillage on the digestive gland of the fan mussel Pinna nobilis (Linnaeus, 1758). Two areas in the southeast of Ibiza Island (Western Mediterranean) were selected; one affected by the oil spill (Talamanca) and one did not affected (Espardell). Mussels were sampled one, six and twelve months after the accident. PAH levels were elevated in P. nobilis from the affected area one month after the accident and, although they were decreasing gradually, they were always higher than in the control area. An increase in enzyme activities, reduced glutathione and lipid peroxidation were evidenced one month after the spillage, with no changes in acetylcholinesterase. All biomarkers progressively returned to basal levels one year after the oil spill. In conclusion, the Don Pedro oil spill induced an acute situation of oxidative stress on P. nobilis that were recovered twelve months later. Copyright © 2015 Elsevier Ltd. All rights reserved.

Mines Systems Safety Improvement Using an Integrated Event Tree and Fault Tree Analysis

NASA Astrophysics Data System (ADS)

Kumar, Ranjan; Ghosh, Achyuta Krishna

2017-04-01

Mines systems such as ventilation system, strata support system, flame proof safety equipment, are exposed to dynamic operational conditions such as stress, humidity, dust, temperature, etc., and safety improvement of such systems can be done preferably during planning and design stage. However, the existing safety analysis methods do not handle the accident initiation and progression of mine systems explicitly. To bridge this gap, this paper presents an integrated Event Tree (ET) and Fault Tree (FT) approach for safety analysis and improvement of mine systems design. This approach includes ET and FT modeling coupled with redundancy allocation technique. In this method, a concept of top hazard probability is introduced for identifying system failure probability and redundancy is allocated to the system either at component or system level. A case study on mine methane explosion safety with two initiating events is performed. The results demonstrate that the presented method can reveal the accident scenarios and improve the safety of complex mine systems simultaneously.

[Neuropathology and pregnancy. 189 consecutive cases (1971--1976) (author's transl)].

PubMed

Faguer, C; Darbois, Y; Pathier, D; Barrat, J; Hervet, E

1978-09-01

The authors report 189 case histories of pregnant women who had a neurological disorder, which either existed before the pregnancy or were discovered during the pregnancy. The most frequent aetiological conditions were, epilepsy, psychoses, vascular accidents, tumours and disseminated sclerosis. Pregnancy and neuropathology are an association for which the prognosis as a whole is good and linked to the time in the pregnancy when the neurological condition, whether it is stable or not, is discovered. The combination is absolutely compatible with the normal progress of pregnancy so long as the appropriate treatment is continued during the pregnancy. Cerebral vascular accidents that occur in pregnancy make the prognosis very much worse. In these circumstances neurosurgery may give some hope. This applies also for cerebral tumours, among which pituitary adenoma is becoming more and more frequent. Psychopathies can be a very baffling chapter when they are combined with pregnancy. Finally disseminated sclerosis, once it has been stabilised, is perfectly compatible with the normal outcome for a pregnancy.

Back to the future: A practice led transition program from Assistant in Nursing to Enrolled Nurse.

PubMed

Faithfull-Byrne, Annette; Thompson, Lorraine; Welch, Tony; Williamson, Moira; Schafer, Keppel; Hallinan, Claire

2017-01-01

Continuing professional development is an essential element in professional nursing practice. In our Hospital and Health service, a gap in existing nursing pathways was identified for Assistants in Nursing (AINs), who wished to further their career in nursing and progress to Enrolled Nurse (EN). There is also little in the literature that addresses Assistants in Nursing wishing to progress their career to Enrolled Nurses. This article describes a quality improvement project designed to address this gap. The project was a collaborative venture between a Queensland Hospital and Health Service and an Institute of Tertiary and Further Education (TAFE). The focus was on creating a flexible career path for Assistants in Nursing, wishing to become Enrolled Nurses. The project resulted in the Diploma of Nursing program (theory and practice) being delivered within the hospital setting by nurse educators and clinical nurse consultants. This is unusual in that the program is normally delivered in the tertiary setting, by academic staff from the Institute of Further Education. Program implementation is described along with the challenges encountered. Outcomes from the project were: 78% completion rate; 100% employment on completion of their course of study; and 18% progressing to further their education such as Advance Enrolled Nurse or Registered Nurse. Student satisfaction regarding the program was also positive. The initiative established a local career path for Assistants in Nursing wishing to progress to Enrolled Nurse. This quality project demonstrates that collaborative ventures between the tertiary sector and hospital and health services, can create innovative flexible solutions for staff wishing to further their career in nursing. Copyright © 2016 Elsevier Ltd. All rights reserved.

MELCOR computer code manuals: Primer and user`s guides, Version 1.8.3 September 1994. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summers, R.M.; Cole, R.K. Jr.; Smith, R.C.

1995-03-01

MELCOR is a fully integrated, engineering-level computer code that models the progression of severe accidents in light water reactor nuclear power plants. MELCOR is being developed at Sandia National Laboratories for the US Nuclear Regulatory Commission as a second-generation plant risk assessment tool and the successor to the Source Term Code Package. A broad spectrum of severe accident phenomena in both boiling and pressurized water reactors is treated in MELCOR in a unified framework. These include: thermal-hydraulic response in the reactor coolant system, reactor cavity, containment, and confinement buildings; core heatup, degradation, and relocation; core-concrete attack; hydrogen production, transport, andmore » combustion; fission product release and transport; and the impact of engineered safety features on thermal-hydraulic and radionuclide behavior. Current uses of MELCOR include estimation of severe accident source terms and their sensitivities and uncertainties in a variety of applications. This publication of the MELCOR computer code manuals corresponds to MELCOR 1.8.3, released to users in August, 1994. Volume 1 contains a primer that describes MELCOR`s phenomenological scope, organization (by package), and documentation. The remainder of Volume 1 contains the MELCOR Users` Guides, which provide the input instructions and guidelines for each package. Volume 2 contains the MELCOR Reference Manuals, which describe the phenomenological models that have been implemented in each package.« less

An inverse method to estimate emission rates based on nonlinear least-squares-based ensemble four-dimensional variational data assimilation with local air concentration measurements.

PubMed

Geng, Xiaobing; Xie, Zhenghui; Zhang, Lijun; Xu, Mei; Jia, Binghao

2018-03-01

An inverse source estimation method is proposed to reconstruct emission rates using local air concentration sampling data. It involves the nonlinear least squares-based ensemble four-dimensional variational data assimilation (NLS-4DVar) algorithm and a transfer coefficient matrix (TCM) created using FLEXPART, a Lagrangian atmospheric dispersion model. The method was tested by twin experiments and experiments with actual Cs-137 concentrations measured around the Fukushima Daiichi Nuclear Power Plant (FDNPP). Emission rates can be reconstructed sequentially with the progression of a nuclear accident, which is important in the response to a nuclear emergency. With pseudo observations generated continuously, most of the emission rates were estimated accurately, except under conditions when the wind blew off land toward the sea and at extremely slow wind speeds near the FDNPP. Because of the long duration of accidents and variability in meteorological fields, monitoring networks composed of land stations only in a local area are unable to provide enough information to support an emergency response. The errors in the estimation compared to the real observations from the FDNPP nuclear accident stemmed from a shortage of observations, lack of data control, and an inadequate atmospheric dispersion model without improvement and appropriate meteorological data. The proposed method should be developed further to meet the requirements of a nuclear emergency response. Copyright © 2017 Elsevier Ltd. All rights reserved.

Qualification of Daiichi Units 1, 2, and 3 Data for Severe Accident Evaluations - Process and Illustrative Examples from Prior TMI-2 Evaluations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rempe, Joy Lynn; Knudson, Darrell Lee

2014-09-01

The accidents at the Three Mile Island Unit 2 (TMI-2) Pressurized Water Reactor (PWR) and the Daiichi Units 1, 2, and 3 Boiling Water Reactors (BWRs) provide unique opportunities to evaluate instrumentation exposed to severe accident conditions. Conditions associated with the release of coolant and the hydrogen burn that occurred during the TMI-2 accident exposed instrumentation to harsh conditions, including direct radiation, radioactive contamination, and high humidity with elevated temperatures and pressures. As part of a program initiated in 2012 by the Department of Energy Office of Nuclear Energy (DOE-NE), a review was completed to gain insights from prior TMI-2more » sensor survivability and data qualification efforts. This initial review focused on the set of sensors deemed most important by post-TMI-2 instrumentation evaluation programs. Instrumentation evaluation programs focused on data required by TMI-2 operators to assess the condition of the reactor and containment and the effect of mitigating actions taken by these operators. In addition, prior efforts focused on sensors providing data required for subsequent forensic evaluations and accident simulations. To encourage the potential for similar activities to be completed for qualifying data from Daiichi Units 1, 2, and 3, this report provides additional details related to the formal process used to develop a qualified TMI-2 data base and presents data qualification details for three parameters: primary system pressure; containment building temperature; and containment pressure. As described within this report, sensor evaluations and data qualification required implementation of various processes, including comparisons with data from other sensors, analytical calculations, laboratory testing, and comparisons with sensors subjected to similar conditions in large-scale integral tests and with sensors that were similar in design to instruments easily removed from the TMI-2 plant for evaluations. As documented in this report, results from qualifying data for these parameters led to key insights related to TMI-2 accident progression. Hence, these selected examples illustrate the types of activities completed in the TMI-2 data qualification process and the importance of such a qualification effort. These details are documented in this report to facilitate implementation of similar process using data and examinations at the Daiichi Units 1, 2, and 3 reactors so that BWR-specific benefits can be obtained.« less

A Formal Methods Approach to the Analysis of Mode Confusion

NASA Technical Reports Server (NTRS)

Butler, Ricky W.; Miller, Steven P.; Potts, James N.; Carreno, Victor A.

2004-01-01

The goal of the new NASA Aviation Safety Program (AvSP) is to reduce the civil aviation fatal accident rate by 80% in ten years and 90% in twenty years. This program is being driven by the accident data with a focus on the most recent history. Pilot error is the most commonly cited cause for fatal accidents (up to 70%) and obviously must be given major consideration in this program. While the greatest source of pilot error is the loss of situation awareness , mode confusion is increasingly becoming a major contributor as well. The January 30, 1995 issue of Aviation Week lists 184 incidents and accidents involving mode awareness including the Bangalore A320 crash 2/14/90, the Strasbourg A320 crash 1/20/92, the Mulhouse-Habsheim A320 crash 6/26/88, and the Toulouse A330 crash 6/30/94. These incidents and accidents reveal that pilots sometimes become confused about what the cockpit automation is doing. Consequently, human factors research is an obvious investment area. However, even a cursory look at the accident data reveals that the mode confusion problem is much deeper than just training deficiencies and a lack of human-oriented design. This is readily acknowledged by human factors experts. It seems that further progress in human factors must come through a deeper scrutiny of the internals of the automation. It is in this arena that formal methods can contribute. Formal methods refers to the use of techniques from logic and discrete mathematics in the specification, design, and verification of computer systems, both hardware and software. The fundamental goal of formal methods is to capture requirements, designs and implementations in a mathematically based model that can be analyzed in a rigorous manner. Research in formal methods is aimed at automating this analysis as much as possible. By capturing the internal behavior of a flight deck in a rigorous and detailed formal model, the dark corners of a design can be analyzed. This paper will explore how formal models and analyses can be used to help eliminate mode confusion from flight deck designs and at the same time increase our confidence in the safety of the implementation. The paper is based upon interim results from a new project involving NASA Langley and Rockwell Collins in applying formal methods to a realistic business jet Flight Guidance System (FGS).

Thermodynamic evaluation of the solidification phase of molten core-concrete under estimated Fukushima Daiichi nuclear power plant accident conditions

NASA Astrophysics Data System (ADS)

Kitagaki, Toru; Yano, Kimihiko; Ogino, Hideki; Washiya, Tadahiro

2017-04-01

The solidification phases of molten core-concrete under the estimated molten core-concrete interaction (MCCI) conditions in the Fukushima Daiichi Nuclear Power Plant Unit 1 were predicted using the thermodynamic equilibrium calculation tool, FactSage 6.2, and the NUCLEA database in order to contribute toward the 1F decommissioning work and to understand the accident progression via the analytical results for the 1F MCCI products. We showed that most of the U and Zr in the molten core-concrete forms (U,Zr)O2 and (Zr,U)SiO4, and the formation of other phases with these elements is limited. However, the formation of (Zr,U)SiO4 requires a relatively long time because it involves a change in the crystal structure from fcc-(U,Zr)O2 to tet-(U,Zr)O2, followed by the formation of (Zr,U)SiO4 by reaction with SiO2. Therefore, the formation of (Zr,U)SiO4 is limited under quenching conditions. Other common phases are the oxide phases, CaAl2Si2O8, SiO2, and CaSiO3, and the metallic phases of the Fe-Si and Fe-Ni alloys. The solidification phenomenon of the crust under quenching conditions and that of the molten pool under thermodynamic equilibrium conditions in the 1F MCCI progression are discussed.

Thermal-Hydraulics Phenomena Important in Modeling and Simulation of Liquid-Fuel Molten Salt Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bajorek, Stephen; Diamond, David J.

This paper discusses liquid-fuel molten salt reactors, how they will operate under normal, transient, and accident conditions, and the results of an expert elicitation to determine the corresponding thermalhydraulic phenomena important to understanding their behavior. Identifying these phenomena will enable the U.S. Nuclear Regulatory Commission (NRC) to develop or identify modeling functionalities and tools required to carry out confirmatory analyses that examine the validity and accuracy of an applicant’s calculations and help determine the margin of safety in plant design. NRC frequently does an expert elicitation using a Phenomena Identification and Ranking Table (PIRT) to identify and evaluate the statemore » of knowledge of important modeling phenomena. However, few details about the design of these reactors and the sequence of events during accidents are known, so the process used was considered a preliminary PIRT. A panel met to define phenomena that would need to be modeled and considered the impact/importance of each phenomenon with respect to specific figures-of-merit (FoMs) (e.g., salt temperature, velocity, and composition). Each FoM reflected a potential impact on radionuclide release or loss of a barrier to release. The panel considered what the path forward might be with respect to being able to model the phenomenon in a simulation code. Results are explained for both thermal and fast spectrum designs.« less

Neutronics Phenomena Important in Modeling and Simulation of Liquid-Fuel Molten Salt Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diamond, David J.

This paper discusses liquid-fuel molten salt reactors, how they will operate under normal, transient, and accident conditions, and the results of an expert elicitation to determine the corresponding neutronic phenomena important to understanding their behavior. Identifying these phenomena will enable the U.S. Nuclear Regulatory Commission (NRC) to develop or identify modeling functionalities and tools required to carry out confirmatory analyses that examine the validity and accuracy of applicants’ calculations and help determine the margin of safety in plant design. NRC frequently does an expert elicitation using a Phenomena Identification and Ranking Table (PIRT) to identify and evaluate the state ofmore » knowledge of important modeling phenomena. However, few details about the design of these reactors and the sequence of events during accidents are known, so the process used was considered a preliminary PIRT. A panel met to define phenomena that would need to be modeled and considered the impact/importance of each phenomenon with respect to specific figures-of-merit (FoMs) (e.g., power distribution, fluence, kinetics parameters and reactivity). Each FoM reflected a potential impact on radionuclide release or loss of a barrier to release. The panel considered what the path forward might be with respect to being able to model the phenomenon in a simulation code. Results are explained for both thermal and fast spectrum designs.« less

Landscape and flux reveal a new global view and physical quantification of mammalian cell cycle

PubMed Central

Li, Chunhe; Wang, Jin

2014-01-01

Cell cycles, essential for biological function, have been investigated extensively. However, enabling a global understanding and defining a physical quantification of the stability and function of the cell cycle remains challenging. Based upon a mammalian cell cycle gene network, we uncovered the underlying Mexican hat landscape of the cell cycle. We found the emergence of three local basins of attraction and two major potential barriers along the cell cycle trajectory. The three local basins of attraction characterize the G1, S/G2, and M phases. The barriers characterize the G1 and S/G2 checkpoints, respectively, of the cell cycle, thus providing an explanation of the checkpoint mechanism for the cell cycle from the physical perspective. We found that the progression of a cell cycle is determined by two driving forces: curl flux for acceleration and potential barriers for deceleration along the cycle path. Therefore, the cell cycle can be promoted (suppressed), either by enhancing (suppressing) the flux (representing the energy input) or by lowering (increasing) the barrier along the cell cycle path. We found that both the entropy production rate and energy per cell cycle increase as the growth factor increases. This reflects that cell growth and division are driven by energy or nutrition supply. More energy input increases flux and decreases barrier along the cell cycle path, leading to faster oscillations. We also identified certain key genes and regulations for stability and progression of the cell cycle. Some of these findings were evidenced from experiments whereas others lead to predictions and potential anticancer strategies. PMID:25228772

Search strategies of Wikipedia readers.

PubMed

Rodi, Giovanna Chiara; Loreto, Vittorio; Tria, Francesca

2017-01-01

The quest for information is one of the most common activity of human beings. Despite the the impressive progress of search engines, not to miss the needed piece of information could be still very tough, as well as to acquire specific competences and knowledge by shaping and following the proper learning paths. Indeed, the need to find sensible paths in information networks is one of the biggest challenges of our societies and, to effectively address it, it is important to investigate the strategies adopted by human users to cope with the cognitive bottleneck of finding their way in a growing sea of information. Here we focus on the case of Wikipedia and investigate a recently released dataset about users' click on the English Wikipedia, namely the English Wikipedia Clickstream. We perform a semantically charged analysis to uncover the general patterns followed by information seekers in the multi-dimensional space of Wikipedia topics/categories. We discover the existence of well defined strategies in which users tend to start from very general, i.e., semantically broad, pages and progressively narrow down the scope of their navigation, while keeping a growing semantic coherence. This is unlike strategies associated to tasks with predefined search goals, namely the case of the Wikispeedia game. In this case users first move from the 'particular' to the 'universal' before focusing down again to the required target. The clear picture offered here represents a very important stepping stone towards a better design of information networks and recommendation strategies, as well as the construction of radically new learning paths.

Search strategies of Wikipedia readers

PubMed Central

2017-01-01

The quest for information is one of the most common activity of human beings. Despite the the impressive progress of search engines, not to miss the needed piece of information could be still very tough, as well as to acquire specific competences and knowledge by shaping and following the proper learning paths. Indeed, the need to find sensible paths in information networks is one of the biggest challenges of our societies and, to effectively address it, it is important to investigate the strategies adopted by human users to cope with the cognitive bottleneck of finding their way in a growing sea of information. Here we focus on the case of Wikipedia and investigate a recently released dataset about users’ click on the English Wikipedia, namely the English Wikipedia Clickstream. We perform a semantically charged analysis to uncover the general patterns followed by information seekers in the multi-dimensional space of Wikipedia topics/categories. We discover the existence of well defined strategies in which users tend to start from very general, i.e., semantically broad, pages and progressively narrow down the scope of their navigation, while keeping a growing semantic coherence. This is unlike strategies associated to tasks with predefined search goals, namely the case of the Wikispeedia game. In this case users first move from the ‘particular’ to the ‘universal’ before focusing down again to the required target. The clear picture offered here represents a very important stepping stone towards a better design of information networks and recommendation strategies, as well as the construction of radically new learning paths. PMID:28152030

From goal motivation to goal progress: the mediating role of coping in the Self-Concordance Model.

PubMed

Gaudreau, Patrick; Carraro, Natasha; Miranda, Dave

2012-01-01

The present studies examined the mediating role of self-regulatory mechanisms in the relationship between goal motivation and goal progress in the Self-Concordance Model. First, a systematic review, using meta-analytical path analysis, supported the mediating role of effort and action planning in the positive association between autonomous goal motivation and goal progress. Second, results from two additional empirical studies, using structural equation modeling, lent credence to the mediating role of coping in the relationship between goal motivation and goal progress of university students. Autonomous goal motivation was positively associated with task-oriented coping, which predicted greater goal progress during midterm exams (Study 1, N=702) and at the end of the semester in a different sample (Study 2, N=167). Controlled goal motivation was associated with greater disengagement-oriented coping (Study 1 and Study 2) and lesser use of task-oriented coping (Study 2), which reduced goal progress. These results held up after controlling for perceived stress (Study 2). Our findings highlight the importance of coping in the "inception-to-attainment" goal process because autonomous goal motivation indirectly rather than directly predicts goal progress of university students through their usage of task-oriented coping.

NASA's Radioisotope Power Systems - Plans

NASA Technical Reports Server (NTRS)

Hamley, John A.; Mccallum, Peter W.; Sandifer, Carl E., II; Sutliff, Thomas J.; Zakrajsek, June F.

2015-01-01

NASA's Radioisotope Power Systems (RPS) Program continues to plan and implement content to enable planetary exploration where such systems could be needed, and to prepare more advanced RPS technology for possible infusion into future power systems. The 2014-2015 period saw significant changes, and strong progress. Achievements of near-term objectives have enabled definition of a clear path forward in which payoffs from research investments and other sustaining efforts can be applied. The future implementation path is expected to yield a higher-performing thermoelectric generator design, a more isotope-fuel efficient system concept design, and a robust RPS infrastructure maintained effectively within both NASA and the Department of Energy. This paper describes recent work with an eye towards the future plans that result from these achievements.

Analysis and elimination of a bias in targeted molecular dynamics simulations of conformational transitions: application to calmodulin.

PubMed

Ovchinnikov, Victor; Karplus, Martin

2012-07-26

The popular targeted molecular dynamics (TMD) method for generating transition paths in complex biomolecular systems is revisited. In a typical TMD transition path, the large-scale changes occur early and the small-scale changes tend to occur later. As a result, the order of events in the computed paths depends on the direction in which the simulations are performed. To identify the origin of this bias, and to propose a method in which the bias is absent, variants of TMD in the restraint formulation are introduced and applied to the complex open ↔ closed transition in the protein calmodulin. Due to the global best-fit rotation that is typically part of the TMD method, the simulated system is guided implicitly along the lowest-frequency normal modes, until the large spatial scales associated with these modes are near the target conformation. The remaining portion of the transition is described progressively by higher-frequency modes, which correspond to smaller-scale rearrangements. A straightforward modification of TMD that avoids the global best-fit rotation is the locally restrained TMD (LRTMD) method, in which the biasing potential is constructed from a number of TMD potentials, each acting on a small connected portion of the protein sequence. With a uniform distribution of these elements, transition paths that lack the length-scale bias are obtained. Trajectories generated by steered MD in dihedral angle space (DSMD), a method that avoids best-fit rotations altogether, also lack the length-scale bias. To examine the importance of the paths generated by TMD, LRTMD, and DSMD in the actual transition, we use the finite-temperature string method to compute the free energy profile associated with a transition tube around a path generated by each algorithm. The free energy barriers associated with the paths are comparable, suggesting that transitions can occur along each route with similar probabilities. This result indicates that a broad ensemble of paths needs to be calculated to obtain a full description of conformational changes in biomolecules. The breadth of the contributing ensemble suggests that energetic barriers for conformational transitions in proteins are offset by entropic contributions that arise from a large number of possible paths.

Scientific realism and wishful thinking in soil hydrology

NASA Astrophysics Data System (ADS)

Flühler, H.

2009-04-01

In our field we often learn - or could have learned - more from failures than from successes provided we had postulated testable hypotheses to be accepted or rejected. In soil hydrology, hypotheses are testable if independent information quantifying the pertinent system features is at hand. This view on how to operate is an idealized concept of how we could or should have worked. In reality, the path to success is more tortuous and we usually progress differently obeying to other professional musts. Although we missed some shortcuts over the past few decades, we definitely made significant progress in understanding vadose zone progresses, but we could have advanced our system understanding faster by more rigorously questioning the fundamental assumptions. I will try to illustrate the tortuous path of learning and identify some causes of the slowed-down learning curve. In the pioneering phase of vadose zone research many models have been mapped in our minds and implemented on our computers. Many of them are now well established, powerful and represent the state-of-the-art even when they do not work. Some of them are based on erroneous or misleading concepts. Even when based on adequate concepts they might have been applied in the wrong context or inadequate models may have lead to apparent success. I address this process of collective learning with the intention that we spend more time and efforts to find the right question instead of improving tools, which are questionably suitable for solving the main problems.

Prospects for School Mathematics. Seventy-Five Years of Progress.

ERIC Educational Resources Information Center

Carl, Iris M., Ed.

This book offers a broad view for a varied audience of what the vision expressed in all three National Council of Teachers of Mathematics' Standards documents will look like when aligned with practice and outlines ways in which desired changes can be realized. Six sections and 21 chapters in the book are: Section I--History: (1) "Paths to the…

Employment Policy for the Hard-to-Employ: The Path of Progress. A Statement by the Program Committee.

ERIC Educational Resources Information Center

Committee for Economic Development, New York, NY.

At a time of high unemployment and increasingly constrained public resources, more and more attention is being focused on how to further the private sector's involvement in expanding opportunities for individuals, especially the hard-to-employ, to obtain long-term productive employment. Although at least 12 pieces of federal legislation that…

The Role of Students' Attitudes and Test-Taking Motivation on the Validity of College Institutional Accountability Tests: A Path Analytic Model

ERIC Educational Resources Information Center

Zilberberg, Anna; Finney, Sara J.; Marsh, Kimberly R.; Anderson, Robin D.

2014-01-01

Given worldwide prevalence of low-stakes testing for monitoring educational quality and students' progress through school (e.g., Trends in International Mathematics and Science Study, Program for International Student Assessment), interpretability of resulting test scores is of global concern. The nonconsequential nature of low-stakes tests…

English Language Publishing in Chemical Engineering Journals from an Indian Academic's Point of View--A Broad Scientific Perspective

ERIC Educational Resources Information Center

Palit, Sukanchan

2016-01-01

Scientific vision and scientific understanding in today's world are in the path of new glory. Chemical Engineering science is witnessing drastic and rapid changes. The metamorphosis of human civilization in this century is faced with vicious challenges. Progress of Chemical Engineering science, the vision of technology and the broad chemical…

Women: The Path to Equal Employment. Research Report No. 56.

ERIC Educational Resources Information Center

Humphrey, Melvin

A study of female employment in the private sector between 1966 and 1975 was done (1) to measure the progress of women toward fair-share goals in level of employment, job quality, and salary level and (2) to project when employment gaps will close. The data utilized was reported by those employers who are required to and did file Employer…

Career Development and Promotion in an Academic Health Center.

PubMed

Christophersen, Edward R

2017-03-01

This paper examines the successive stages of the career path for psychologists who commit to spending their professional lives working in academic health centers. Key factors for success at each stage are described, as are the steps required for progressing to subsequent stages of professional development. The paper breaks new ground by including consideration of a post-retirement stage, "Professor Emeritus status."

Stackable Credentials: Do They Have Labor Market Value? CCRC Working Paper No. 97

ERIC Educational Resources Information Center

Bailey, Thomas; Belfield, Clive R.

2017-01-01

Stackable credentials--sequential postsecondary awards that allow individuals to progress on a career path--have been suggested as a way to enhance the labor market prospects of middle-skill workers. Yet, thus far, little evidence has been provided on the economic value of these credentials. Here, we report a series of estimates on the association…

The path towards sustainable energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, Steven; Cui, Yi; Liu, Nian

Civilization continues to be transformed by our ability to harness energy beyond human and animal power. A series of industrial and agricultural revolutions have allowed an increasing fraction of the world population to heat and light their homes, fertilize and irrigate their crops, connect to one another and travel around the world. All of this progress is fuelled by our ability to find, extract and use energy with ever increasing dexterity. Lastly, research in materials science is contributing to progress towards a sustainable future based on clean energy generation, transmission and distribution, the storage of electrical and chemical energy, energymore » efficiency, and better energy management systems.« less

The path towards sustainable energy

DOE PAGES

Chu, Steven; Cui, Yi; Liu, Nian

2016-12-20

Civilization continues to be transformed by our ability to harness energy beyond human and animal power. A series of industrial and agricultural revolutions have allowed an increasing fraction of the world population to heat and light their homes, fertilize and irrigate their crops, connect to one another and travel around the world. All of this progress is fuelled by our ability to find, extract and use energy with ever increasing dexterity. Lastly, research in materials science is contributing to progress towards a sustainable future based on clean energy generation, transmission and distribution, the storage of electrical and chemical energy, energymore » efficiency, and better energy management systems.« less

[Infectious pathology: vulvovaginitis, sexually transmitted diseases, pelvic inflammatory disease, tubo-ovarian abscesses].

PubMed

Ibarrola Vidaurre, M; Benito, J; Azcona, B; Zubeldía, N

2009-01-01

Sexually transmitted diseases are those where the principal path of infection is through intimate contact. Numerous patients attend Accidents and emergencies for this reason, both because of the clinical features and because of social implications. The most frequent symptoms are lower abdominal pain, vaginal bleeding or excessive or troubling vaginal flow. Vulvovaginites are one of the principal problems in the everyday clinical practice of gynaecology. A genital ulcer whose principal aetiology is herpes, followed by syphilis and chancroid, increases the risk of contracting HIV infection and alters the course of other sexually transmitted diseases. Inflammatory pelvic disease encompasses infections of the upper female genital tract. The importance of early diagnosis and suitable treatment is both due to the complications in its acute phase and to its sequels, which include chronic pain and sterility.

Communicating Geographical Risks in Crisis Management: The Need for Research.

PubMed

French, Simon; Argyris, Nikolaos; Haywood, Stephanie M; Hort, Matthew C; Smith, Jim Q

2017-10-23

In any crisis, there is a great deal of uncertainty, often geographical uncertainty or, more precisely, spatiotemporal uncertainty. Examples include the spread of contamination from an industrial accident, drifting volcanic ash, and the path of a hurricane. Estimating spatiotemporal probabilities is usually a difficult task, but that is not our primary concern. Rather, we ask how analysts can communicate spatiotemporal uncertainty to those handling the crisis. We comment on the somewhat limited literature on the representation of spatial uncertainty on maps. We note that many cognitive issues arise and that the potential for confusion is high. We note that in the early stages of handling a crisis, the uncertainties involved may be deep, i.e., difficult or impossible to quantify in the time available. In such circumstance, we suggest the idea of presenting multiple scenarios. © 2017 Society for Risk Analysis.

Multichannel Spectrometer of Time Distribution

NASA Astrophysics Data System (ADS)

Akindinova, E. V.; Babenko, A. G.; Vakhtel, V. M.; Evseev, N. A.; Rabotkin, V. A.; Kharitonova, D. D.

2015-06-01

For research and control of characteristics of radiation fluxes, radioactive sources in particular, for example, in paper [1], a spectrometer and methods of data measurement and processing based on the multichannel counter of time intervals of accident events appearance (impulses of particle detector) MC-2A (SPC "ASPECT") were created. The spectrometer has four independent channels of registration of time intervals of impulses appearance and correspondent amplitude and spectrometric channels for control along the energy spectra of the operation stationarity of paths of each of the channels from the detector to the amplifier. The registration of alpha-radiation is carried out by the semiconductor detectors with energy resolution of 16-30 keV. Using a spectrometer there have been taken measurements of oscillations of alpha-radiation 239-Pu flux intensity with a subsequent autocorrelative statistical analysis of the time series of readings.

Under pressure: progressively enlarging facial mass following high-pressure paint injection injury.

PubMed

Mushtaq, Jameel; Walker, Abigail; Hunter, Ben

2016-01-19

High-pressure paint injection injuries are relatively rare industrial accidents and almost exclusively occur on the non-dominant hand. A rarely documented complication of these injuries is the formation of a foreign body granuloma. We report a case of a 33-year-old man presenting with extensive facial scarring and progressive right paranasal swelling 7 years after a high-pressure paint injury. After imaging investigations, an excision of the mass and revision of scarring was performed. Access to the mass was gained indirectly through existing scarring over the nose to ensure an aesthetic result. Histological analysis revealed a florid granulomatous foreign body reaction to retained paint. To the best of our knowledge, this is the first reported case of a facial high-pressure paint injury with consequent formation of a foreign body granuloma. 2016 BMJ Publishing Group Ltd.

Virtually driving: are the driving environments "real enough" for exposure therapy with accident victims? An explorative study.

PubMed

Walshe, David; Lewis, Elizabeth; O'Sullivan, Kathleen; Kim, Sun I

2005-12-01

There is a small but growing body of research supporting the effectiveness of computer-generated environments in exposure therapy for driving phobia. However, research also suggests that difficulties can readily arise whereby patients do not immerse in simulated driving scenes. The simulated driving environments are not "real enough" to undertake exposure therapy. This sets a limitation to the use of virtual reality (VR) exposure therapy as a treatment modality for driving phobia. The aim of this study was to investigate if a clinically acceptable immersion/presence rate of >80% could be achieved for driving phobia subjects in computer generated environments by modifying external factors in the driving environment. Eleven patients referred from the Accident and Emergency Department of a general hospital or from their General Practitioner following a motor vehicle accident, who met DSM-IV criteria for Specific Phobia-driving were exposed to a computer-generated driving environment using computer driving games (London Racer/Midtown Madness). In an attempt to make the driving environments "real enough," external factors were modified by (a) projection of images onto a large screen, (b) viewing the scene through a windscreen, (c) using car seats for both driver and passenger, and (d) increasing vibration sense through use of more powerful subwoofers. Patients undertook a trial session involving driving through computer environments with graded risk of an accident. "Immersion/presence" was operationally defined as a subjective rating by the subject that the environment "feels real," together with an increase in subjective units of distress (SUD) ratings of >3 and/or an increase of heart rate of >15 beats per minute (BPM). Ten of 11 (91%) of the driving phobic subjects met the criteria for immersion/presence in the driving environment enabling progression to VR exposure therapy. These provisional findings suggest that the paradigm adopted in this study might be an effective and relatively inexpensive means of developing driving environments "real enough," to make VR exposure therapy a viable treatment modality for driving phobia following a motor vehicle accident (MVA).

Statistical Analysis of the Links between Blocking and Nor'easters

NASA Astrophysics Data System (ADS)

Booth, J. F.; Pfahl, S.

2015-12-01

Nor'easters can be loosely defined as extratropical cyclones that develop as they progress northward along the eastern coast of North America. The path makes it possible for these storms to generate storm surge along the coastline and/or heavy precipitation or snow inland. In the present analysis, the path of the storms is investigated relative to the behavior of upstream blocking events over the North Atlantic Ocean. For this analysis, two separate Lagrangian tracking methods are used to identify the extratropical cyclone paths and the blocking events. Using the cyclone paths, Nor'easters are identified and blocking statistics are calculated for the days prior to, during and following the occurrence of the Nor'easters. The path, strength and intensification rates of the cyclones are compared with the strength and location of the blocks. In the event that a Nor'easter occurs, the likelihood of the presence of block at the southeast tip of Greenland is statistically significantly increased, i.e., the presence of a block concurrent with a Nor'easter happens more often than by random coincidence. However no significant link between the strength of the storms and the strength of the block is identified. These results suggest that the presence of the block mainly affects the path of the Nor'easters. On the other hand, in the event of blocking at the southeast tip of Greenland, the likelihood of a Nor'easter, as opposed to a different type of storm is no greater than what one might expect from randomly sampling cyclone tracks. The results confirm a long held understanding in forecast meteorology that upstream blocking is a necessary but not sufficient condition for generating a Nor'easter.

Operative treatment of sternal fractures.

PubMed

Al-Qudah, Abdullah

2006-10-01

Four patients with displaced sternal fractures complained of intractable pain following road traffic accidents. They all had bone deformities, but only one had associated traumatic injuries. All patients underwent operative reduction and fixation of the fractured sternum using a T-shaped compression-tension stainless steel plate and screws. Pain relief was often dramatic and all patients progressed to sternal union. None required reoperation. No infections occurred. Two plates have subsequently been removed. On follow-up, all patients had excellent results. Sternal plating, which is based on the tension-band principle, is an effective treatment for displaced sternal fractures.

[Hepatic artery pseudoaneurysm following blunt abdominal injury].

PubMed

Kargl, S; Breitwieser, J; Gitter, R; Pumberger, W

2012-12-01

Posttraumatic hepatic artery pseudoaneurysms are a rare but life-threatening complication of blunt abdominal trauma with liver damage. We report the case of a child who developed a pseudoaneurysm of the right hepatic artery after a bicycle accident with central liver rupture. After an episode of hemodynamically relevant hemobilia due to delayed bleeding, the asymptomatic pseudoaneurysm was diagnosed coincidentally by ultrasound. Because of the progression in size angiographic coiling was performed and led to thrombotic occlusion of the pseudoaneurysm. After a symptom-free period of 1 month the child required surgery because of acute cholecystitis.

Research on International Space Station - Building a Partnership for the Future

NASA Technical Reports Server (NTRS)

Gindl, Heinz; Scheimann, Jens; Shirakawa, Masaki; Suvorov, Vadim; Uri, John J.

2004-01-01

As its name implies, the International Space Station is a platform where the research programs of 16 partner nations are conducted. While each partner pursues its own research priorities, cooperation and coordination of the various national and agency research programs occurs at multiple levels, from strategic through tactical planning to experiment operations. Since 2000, a significant number of experiments have been carried out in the Russian ISS utilization program, which consists of the Russian national program of fundamental and applied research in 11 research areas and international cooperative programs and contract activities. The US research program began with simple payloads in 2000 and was significantly expanded with the addition of the US Laboratory module Destiny in 2001, and its outfitting with seven research racks to date. The Canadian Space Agency (CSA), the European Space Agency (ESA) and the Japan Aerospace Exploration Agency (JAXA) have made use of international cooperative arrangements with both the US and Russia to implement a variety of investigations in diverse research areas, and in the case of ESA included the flights of crewmembers to ISS as part of Soyuz Science Missions. In the future, ESA and JAXA will add their own research modules, Columbus and Kibo, respectively, to expand research capabilities both inside and outside ISS. In the aftermath of the Columbia accident and the temporary grounding of the Space Shuttle fleet, all ISS logistics have relied on Russian Progress and Sopz vehicles. The Russian national program has continued as before the Shuttle accident, as have international cooperative programs and contract activities, both during long-duration expeditions and visiting taxi missions. In several instances, Russian international cooperative activities with JAXA and ESA have also involved the use of US facilities and crewmembers in successful truly multilateral efforts. The US research program was rapidly refocused after the Shuttle accident to rely on greatly reduced upmass, and for the first time in the ISS program, US research hardware was launched on Progress vehicles and returned with crews on Soyuz spacecraft. It is hoped that these small but significant steps in international cooperation will lead to even greater endeavors once the remaining research modules are added to ISS.

Atmospheric radioactivity of Cs-134/137 observed at Namie, Fukushima: seasonal variation and contribution of biological re-suspension.

NASA Astrophysics Data System (ADS)

Kita, K.

2015-12-01

Radionuclides emitted by the accident in Fukushima dai-ichi nuclear power plant (FNDPP) have been deposited on the soil, ocean and vegetation. Even after about 4 years since the FNDPP accident significant activities of the radionuclides have been observed over severely contaminated areas. Re-suspension of radioactive cesium from the soil and vegetation to the atmosphere has been one of significant paths for its diffusion after the accident. Although the quantitative understanding of the re-suspensions is important for the prediction of future transition of radionuclides, its mechanism, identification of aerosol species which bring radioactive cesium, and the resuspension flux have not been understood in Fukushima. 　We are continuously measuring atmospheric concentration of Cs-134/137 radioactivity at Tsushima, Namie-town, located about 30km northwest from FNDPP with high-volume air samplers. It showed clear seasonal variation: it increase from April to June, and decreased from September to December. In winter and spring, it was weakly but positively correlated with the surface wind speed. On the contrary, it did not depend on the wind speed in summer and autumn. It also has different diurnal variation: higher activities were observed in daytime in winter/spring, while the activities were obviously higher in nighttime in summer/autumn. The size distribution of aerosols contributing to the Cs-134/137 re-suspension has been measured using cascade impactors attached with high-volume air samplers, and it also shows different features in winter/spring and summer/autumn. These results indicate that the mechanism of the Cs-134/137 re-suspension is different with the season in Fukushima. Scanning electron microscope observation showed that most of suspended coarse particles were soil particles in spring and biogenic particles in autumn. Details on the Cs-134/137 re-suspension mechanisms revealed by our observations and contribution of biogenic emission will be presented in the meeting.

Association Between Receptivity to Tobacco Advertising and Progression to Tobacco Use in Youth and Young Adults in the PATH Study.

PubMed

Pierce, John P; Sargent, James D; Portnoy, David B; White, Martha; Noble, Madison; Kealey, Sheila; Borek, Nicolette; Carusi, Charles; Choi, Kelvin; Green, Victoria R; Kaufman, Annette R; Leas, Eric; Lewis, M Jane; Margolis, Katherine A; Messer, Karen; Shi, Yuyan; Silveira, Marushka L; Snyder, Kimberly; Stanton, Cassandra A; Tanski, Susanne E; Bansal-Travers, Maansi; Trinidad, Dennis; Hyland, Andrew

2018-03-26

Cigarette marketing contributes to initiation of cigarette smoking among young people, which has led to restrictions on use of cigarette advertising. However, little is known about other tobacco advertising and progression to tobacco use in youth and young adults. To investigate whether receptivity to tobacco advertising among youth and young adults is associated with progression (being a susceptible never user or ever user) to use of the product advertised, as well as conventional cigarette smoking. The Population Assessment of Tobacco and Health (PATH) Study at wave 1 (2013-2014) and 1-year follow-up at wave 2 (2014-2015) was conducted in a US population-based sample of never tobacco users aged 12 to 24 years from wave 1 of the PATH Study (N = 10 989). Household interviews using audio computer-assisted self-interviews were conducted. Advertising for conventional cigarettes, electronic cigarettes (e-cigarettes), cigars, and smokeless tobacco products at wave 1. Progression to susceptibility or ever tobacco use at 1-year follow-up in wave 2. Of the 10 989 participants (5410 male [weighted percentage, 48.3%]; 5579 female [weighted percentage, 51.7%]), receptivity to any tobacco advertising at wave 1 was high for those aged 12 to 14 years (44.0%; 95% confidence limit [CL], 42.6%-45.4%) but highest for those aged 18 to 21 years (68.7%; 95% CL, 64.9%-72.2%). e-Cigarette advertising had the highest receptivity among all age groups. For those aged 12 to 17 years, susceptibility to use a product at wave 1 was significantly associated with product use at wave 2 for conventional cigarettes, e-cigarettes, cigars, and smokeless tobacco products. Among committed never users aged 12 to 17 years at wave 1, any receptivity was associated with progression toward use of the product at wave 2 (conventional cigarettes: adjusted odds ratio [AOR], 1.43; 95% CL, 1.23-1.65; e-cigarettes: AOR, 1.62; 95% CL, 1.41-1.85; cigars: AOR, 2.01; 95% CL, 1.62-2.49; and smokeless (males only): AOR, 1.42; 95% CL, 1.07-1.89) and with use of the product (conventional cigarettes: AOR, 1.54; 95% CL, 1.03-2.32; e-cigarettes: AOR, 1.45; 95% CL, 1.19-1.75; cigars: AOR, 2.07; 95% CL, 1.26-3.40). Compared with those not receptive to any product advertising, receptivity to e-cigarette advertising, but not to cigarette advertising, was independently associated with those aged 12 to 21 years having used a cigarette at wave 2 (AOR, 1.60; 95% CL, 1.08-2.38). Receptivity to tobacco advertising was significantly associated with progression toward use in adolescents. Receptivity was highest for e-cigarette advertising and was associated with trying a cigarette.

Applying the Rule Space Model to Develop a Learning Progression for Thermochemistry

NASA Astrophysics Data System (ADS)

Chen, Fu; Zhang, Shanshan; Guo, Yanfang; Xin, Tao

2017-12-01

We used the Rule Space Model, a cognitive diagnostic model, to measure the learning progression for thermochemistry for senior high school students. We extracted five attributes and proposed their hierarchical relationships to model the construct of thermochemistry at four levels using a hypothesized learning progression. For this study, we developed 24 test items addressing the attributes of exothermic and endothermic reactions, chemical bonds and heat quantity change, reaction heat and enthalpy, thermochemical equations, and Hess's law. The test was administered to a sample base of 694 senior high school students taught in 3 schools across 2 cities. Results based on the Rule Space Model analysis indicated that (1) the test items developed by the Rule Space Model were of high psychometric quality for good analysis of difficulties, discriminations, reliabilities, and validities; (2) the Rule Space Model analysis classified the students into seven different attribute mastery patterns; and (3) the initial hypothesized learning progression was modified by the attribute mastery patterns and the learning paths to be more precise and detailed.

The James Webb Space Telescope: Observatory Status and the Path to Launch

NASA Technical Reports Server (NTRS)

McElwain, Michael; Bowers, Chuck; Clampin, Mark; Niedner, Mal

2016-01-01

JWST will carry out transformative science from the very early universe and across cosmic time. JWST OTE and ISIM have been combined to form OTIS, which will commence environmental testing. The full JWST team has made tremendous progress since the last AT+I meeting in 2014.JWST on track following 2011 replan and remains on schedule to launch in October 2018.

Band-Limited Masks and Direct Imaging of Exoplanets

NASA Technical Reports Server (NTRS)

Kuchner, Marc J.

2009-01-01

Band-limited masks have become the baseline design for what is now called "classical TPF" and also the N|RCamcomnagraphonJW8 .This technology remains one of the most promising paths for direct detection ofmxop|anedm and disks. I'll describe some of the latest progress in the implementation of this technique and what we have learned about where it can and can not be effectively applied.

Joint Services Electronics Program.

DTIC Science & Technology

1987-04-30

the specific objectives and progress in each work unit are reported. The focus of the JSEP project on transport properties of 1- dimensional...path. The properties of carrier transport and storage in various regions of these ultra-small, 3- dimensionally confined structures are not well...capabilities of MBE to grow and investigate the transport in these materials. SUMMARY OF RESEARCH: 1. One Dimensional Electron Transport One of the major goals

Divine Interventions: Needs Analysis for Post-Graduate Academic Literacy and Curriculum Development, in a South African School of Theology

ERIC Educational Resources Information Center

Jackson, Fiona

2005-01-01

This paper provides a critical exploration of work in progress to develop a genre based academic support that promotes post-graduate academic literacies among new EIL and EAL Hons and Masters students in the School of Theology, University of Natal, Pietermaritzburg. It traces the path of an action research project, using an eclectic needs analysis…

Automation Improvements for Synchrotron Based Small Angle Scattering Using an Inexpensive Robotics Platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quintana, John P.

This paper reports on the progress toward creating semi-autonomous motion control platforms for beamline applications using the iRobot Create registered platform. The goal is to create beamline research instrumentation where the motion paths are based on the local environment rather than position commanded from a control system, have low integration costs and also be scalable and easily maintainable.

Learning from the unexpected in life and DNA self-assembly

PubMed Central

2015-01-01

Summary The greatest lessons in life and science often arise from the unexpected. Thus, rather than viewing these experiences as hindering our progress, they should be embraced and appreciated for their ability to lead to new discoveries. In this perspective, I will discuss the unexpected events that have shaped my career path and the early stages of my independent research program. PMID:26877793

Users Manual for the Dynamic Student Flow Model.

DTIC Science & Technology

1981-07-31

populations within each pipeline are reasonably homogeneous and the pipeline curriculum provides a structured path along which the student must progress...curriculum is structured, student populations are non-homogeneous. They are drawn from diverse sources such as the Naval Aca- demy, NROTC and the Aviation...Officer Candidate program in numbers subjectively determined to provide the best population for subsequent flight training. His- torically, different

Path of infectious diseases in Brazil in the last 50 years: an ongoing challenge

PubMed Central

Waldman, Eliseu Alves; Sato, Ana Paula Sayuri

2016-01-01

ABSTRACT In this article, we comment on the main features of infectious diseases in Brazil in the last 50 years, highlighting how much of this path Revista de Saúde Pública could portray. From 1967 to 2016, 1,335 articles focusing on infectious diseases were published in Revista de Saúde Pública. Although the proportion of articles on the topic have decreased from about 50.0% to 15.0%, its notability remained and reflected the growing complexity of the research required for its control. It is noteworthy that studies design and analysis strategies progressively became more sophisticated, following the great development of epidemiology in Brazil in the recent decades. Thus, the journal has followed the success of public health interventions that permitted to control or eliminate numerous infectious diseases – which were responsible, in the past, for high rates of morbidity and mortality –, and also followed the reemergence of diseases already controlled and the emergence of until then unknown diseases, with a strong impact on the Brazilian population, establishing a little predictable and very challenging path. PMID:28099652

Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers.

PubMed

Nivaskumar, Mangayarkarasi; Bouvier, Guillaume; Campos, Manuel; Nadeau, Nathalie; Yu, Xiong; Egelman, Edward H; Nilges, Michael; Francetic, Olivera

2014-05-06

The closely related bacterial type II secretion (T2S) and type IV pilus (T4P) systems are sophisticated machines that assemble dynamic fibers promoting protein transport, motility, or adhesion. Despite their essential role in virulence, the molecular mechanisms underlying helical fiber assembly remain unknown. Here, we use electron microscopy and flexible modeling to study conformational changes of PulG pili assembled by the Klebsiella oxytoca T2SS. Neural network analysis of 3,900 pilus models suggested a transition path toward low-energy conformations driven by progressive increase in fiber helical twist. Detailed predictions of interprotomer contacts along this path were tested by site-directed mutagenesis, pilus assembly, and protein secretion analyses. We demonstrate that electrostatic interactions between adjacent protomers (P-P+1) in the membrane drive pseudopilin docking, while P-P+3 and P-P+4 contacts determine downstream fiber stabilization steps. These results support a model of a spool-like assembly mechanism for fibers of the T2SS-T4P superfamily. Copyright © 2014 Elsevier Ltd. All rights reserved.

Distinct docking and stabilization steps of the pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers

PubMed Central

Nivaskumar, Mangayarkarasi; Bouvier, Guillaume; Campos, Manuel; Nadeau, Nathalie; Yu, Xiong; Egelman, Edward H.; Nilges, Michael; Francetic, Olivera

2014-01-01

SUMMARY The closely related bacterial type II secretion (T2S) and type IV pilus (T4P) systems are sophisticated machines that assemble dynamic fibers promoting protein transport, motility or adhesion. Despite their essential role in virulence, the molecular mechanisms underlying helical fiber assembly remain unknown. Here we use electron microscopy and flexible modeling to study conformational changes of PulG pili assembled by the Klebsiella oxytoca T2SS. Neural network analysis of 3900 pilus models suggested a transition path towards low-energy conformations driven by progressive increase in fiber helical twist. Detailed predictions of inter-protomer contacts along this path were tested by site-directed mutagenesis, pilus assembly and protein secretion analyses. We demonstrate that electrostatic interactions between adjacent protomers (P-P+1) in the membrane drive pseudopilin docking, while P-P+3 and P-P+4 contacts determine downstream fiber stabilization steps. These results support a new model of a spool-like assembly mechanism for fibers of the T2SS-T4P superfamily. PMID:24685147

The role of PRA in the safety assessment of VVER Nuclear Power Plants in Ukraine.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kot, C.

1999-05-10

Ukraine operates thirteen (13) Soviet-designed pressurized water reactors, VVERS. All Ukrainian plants are currently operating with annually renewable permits until they update their safety analysis reports (SARs), in accordance with new SAR content requirements issued in September 1995, by the Nuclear Regulatory Authority and the Government Nuclear Power Coordinating Committee of Ukraine. The requirements are in three major areas: design basis accident (DBA) analysis, probabilistic risk assessment (PRA), and beyond design-basis accident (BDBA) analysis. The last two requirements, on PRA and BDBA, are new, and the DBA requirements are an expanded version of the older SAR requirements. The US Departmentmore » of Energy (USDOE), as part of its Soviet-Designed Reactor Safety activities, is providing assistance and technology transfer to Ukraine to support their nuclear power plants (NPPs) in developing a Western-type technical basis for the new SARs. USDOE sponsored In-Depth Safety Assessments (ISAs) are in progress at three pilot nuclear reactor units in Ukraine, South Ukraine Unit 1, Zaporizhzhya Unit 5, and Rivne Unit 1, and a follow-on study has been initiated at Khmenytskyy Unit 1. The ISA projects encompass most areas of plant safety evaluation, but the initial emphasis is on performing a detailed, plant-specific Level 1 Internal Events PRA. This allows the early definition of the plant risk profile, the identification of risk significant accident sequences and plant vulnerabilities and provides guidance for the remainder of the safety assessments.« less

Distributed Water Pollution Source Localization with Mobile UV-Visible Spectrometer Probes in Wireless Sensor Networks.

PubMed

Ma, Junjie; Meng, Fansheng; Zhou, Yuexi; Wang, Yeyao; Shi, Ping

2018-02-16

Pollution accidents that occur in surface waters, especially in drinking water source areas, greatly threaten the urban water supply system. During water pollution source localization, there are complicated pollutant spreading conditions and pollutant concentrations vary in a wide range. This paper provides a scalable total solution, investigating a distributed localization method in wireless sensor networks equipped with mobile ultraviolet-visible (UV-visible) spectrometer probes. A wireless sensor network is defined for water quality monitoring, where unmanned surface vehicles and buoys serve as mobile and stationary nodes, respectively. Both types of nodes carry UV-visible spectrometer probes to acquire in-situ multiple water quality parameter measurements, in which a self-adaptive optical path mechanism is designed to flexibly adjust the measurement range. A novel distributed algorithm, called Dual-PSO, is proposed to search for the water pollution source, where one particle swarm optimization (PSO) procedure computes the water quality multi-parameter measurements on each node, utilizing UV-visible absorption spectra, and another one finds the global solution of the pollution source position, regarding mobile nodes as particles. Besides, this algorithm uses entropy to dynamically recognize the most sensitive parameter during searching. Experimental results demonstrate that online multi-parameter monitoring of a drinking water source area with a wide dynamic range is achieved by this wireless sensor network and water pollution sources are localized efficiently with low-cost mobile node paths.

Distributed Water Pollution Source Localization with Mobile UV-Visible Spectrometer Probes in Wireless Sensor Networks

PubMed Central

Zhou, Yuexi; Wang, Yeyao; Shi, Ping

2018-01-01

Pollution accidents that occur in surface waters, especially in drinking water source areas, greatly threaten the urban water supply system. During water pollution source localization, there are complicated pollutant spreading conditions and pollutant concentrations vary in a wide range. This paper provides a scalable total solution, investigating a distributed localization method in wireless sensor networks equipped with mobile ultraviolet-visible (UV-visible) spectrometer probes. A wireless sensor network is defined for water quality monitoring, where unmanned surface vehicles and buoys serve as mobile and stationary nodes, respectively. Both types of nodes carry UV-visible spectrometer probes to acquire in-situ multiple water quality parameter measurements, in which a self-adaptive optical path mechanism is designed to flexibly adjust the measurement range. A novel distributed algorithm, called Dual-PSO, is proposed to search for the water pollution source, where one particle swarm optimization (PSO) procedure computes the water quality multi-parameter measurements on each node, utilizing UV-visible absorption spectra, and another one finds the global solution of the pollution source position, regarding mobile nodes as particles. Besides, this algorithm uses entropy to dynamically recognize the most sensitive parameter during searching. Experimental results demonstrate that online multi-parameter monitoring of a drinking water source area with a wide dynamic range is achieved by this wireless sensor network and water pollution sources are localized efficiently with low-cost mobile node paths. PMID:29462929

Health transition: examples from the western Pacific.

PubMed

Baker, P T; Garruto, R M

1992-12-01

The Industrial Revolution ushered in a rapid transition from agriculture to industrialization. Some biological effects of this transition included increasing life expectancy, reduced infant mortality, and some decline in fertility. Reduced infant mortality first brought about an increase in life expectancy, but as humans were able to control infectious diseases, child and adult mortality also decreased. Now, accidents and chronic diseases are responsible for most mortality in many age groups. This shift from infectious diseases to accidents and chronic diseases is called the health transition. Japan and US are Pacific Basin countries which have relatively high life expectancy and low infant mortality (1988, 75.54 years vs. 71.38 years, and 4.4 vs. 9.9, respectively). These figures suggest that these countries rather advanced in the health transition. Japan may have better life expectancy than the US because of the effect of environmental factors, ethnic diversity, and health care differentials by social class on cardiovascular disease and cancer mortality. China and Thailand hold intermediate positions (67.98 years (1985-1990) vs. 63.82 years (1985-1986), and 32.4 vs. 39, respectively). Some research indicates that urban conditions and factory work increase the cardiovascular disease risk among the Chinese. Recent research suggests that access to immunization and modern medical care for acute disease are the only critical variables of the health transition rather than other variables. Papua New Guinea is not progressing very well (53.18 years and 58). Papua New Guinea has not yet been able to control infectious diseases, especially malaria. This comparison illustrates that populations progress through the health transition at different rates.

From Confrontation to Cooperation: 8th International Seminar on Nuclear War

NASA Astrophysics Data System (ADS)

Zichichi, A.; Dardo, M.

1992-09-01

The Table of Contents for the full book PDF is as follows: * OPENING SESSION * A. Zichichi: Opening Statements * R. Nicolosi: Opening Statements * MESSAGES * CONTRIBUTIONS * "The Contribution of the Erice Seminars in East-West-North-South Scientific Relations" * 1. LASER TECHNOLOGY * "Progress in laser technology" * "Progress in laboratory high gain ICF: prospects for the future" * "Applications of laser in metallurgy" * "Laser tissue interactions in medicine and surgery" * "Laser fusion" * "Compact X-ray lasers in the laboratory" * "Alternative method for inertial confinement" * "Laser technology in China" * 2. NUCLEAR AND CHEMICAL SAFETY * "Reactor safety and reactor design" * "Thereotical analysis and numerical modelling of heat transfer and fuel migration in underlying soils and constructive elements of nuclear plants during an accident release from the core" * "How really to attain reactor safely" * "The problem of chemical weapons" * "Long terms genetic effects of nuclear and chemical accidents" * "Features of the brain which are of importance in understanding the mode of operation of toxic substances and of radiation" * "CO2 and ultra safe reactors" * 3. USE OF MISSILES * "How to convert INF technology for peaceful scientific purposes" * "Beating words into plowshares: a proposal for the peaceful uses of retired nuclear warheads" * "Some thoughts on the peaceful use of retired nuclear warheads" * "Status of the HEFEST project" * 4. OZONE * "Status of the ozone layer problem" * 5. CONVENTIONAL AND NUCLEAR FORCE RESTRUCTURING IN EUROPE * 6. CONFLICT AVOIDANCE MODEL * 7. GENERAL DISCUSSION OF THE WORLD LAB PROJECTS * "East-West-North-South Collaboration in Subnuclear Physics" * "Status of the World Lab in the USSR" * CLOSING SESSION

The power of simplification: Operator interface with the AP1000{sup R} during design-basis and beyond design-basis events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, M. G.; Mouser, M. R.; Simon, J. B.

2012-07-01

The AP1000{sup R} plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and cost. The passive safety features are designed to function without safety-grade support systems such as component cooling water, service water, compressed air or HVAC. The AP1000 passive safety features achieve and maintain safe shutdown in case of a design-basis accident for 72 hours without need for operator action, meeting the expectations provided in the European Utility Requirements and the Utility Requirement Document for passive plants. Limited operator actions may be required to maintain safe conditionsmore » in the spent fuel pool (SFP) via passive means. This safety approach therefore minimizes the reliance on operator action for accident mitigation, and this paper examines the operator interaction with the Human-System Interface (HSI) as the severity of an accident increases from an anticipated transient to a design basis accident and finally, to a beyond-design-basis event. The AP1000 Control Room design provides an extremely effective environment for addressing the first 72 hours of design-basis events and transients, providing ease of information dissemination and minimal reliance upon operator actions. Symptom-based procedures including Emergency Operating Procedures (EOPs), Abnormal Operating Procedures (AOPs) and Alarm Response Procedures (ARPs) are used to mitigate design basis transients and accidents. Use of the Computerized Procedure System (CPS) aids the operators during mitigation of the event. The CPS provides cues and direction to the operators as the event progresses. If the event becomes progressively worse or lasts longer than 72 hours, and depending upon the nature of failures that may have occurred, minimal operator actions may be required outside of the control room in areas that have been designed to be accessible using components that have been designed to be reliable in these conditions. The primary goal of any such actions is to maintain or refill the passive inventory available to cool the core, containment and spent fuel pool in the safety-related and seismically qualified Passive Containment Cooling Water Storage Tank (PCCWST). The seismically-qualified, ground-mounted Passive Containment Cooling Ancillary Water Storage Tank (PCCAWST) is also available for this function as appropriate. The primary effect of these actions would be to increase the coping time for the AP1000 during design basis events, as well as events such as those described above, from 72 hours without operator intervention to 7 days with minimal operator actions. These Operator actions necessary to protect the health and safety of the public are addressed in the Post-72 Hour procedures, as well as some EOPs, AOPs, ARPs and the Severe Accident Management Guidelines (SAMGs). Should the event continue to become more severe and plant conditions degrade further with indications of inadequate core cooling, the SAMGs provide guidance for strategies to address these hypothetical severe accident conditions. The AP1000 SAMG diagnoses and actions are prioritized to first utilize the AP1000 features that are expected to retain a damaged core inside the reactor vessel. Only one strategy is undertaken at any time. This strategy will be followed and its effectiveness evaluated before other strategies are undertaken. This is a key feature of both the symptom-oriented AP1000 EOPs and the AP1000 SAMGs which maximizes the probability of retaining a damaged core inside the reactor vessel and containment while minimizing the chances for confusion and human errors during implementation. The AP1000 SAMGs are simple and straight-forward and have been developed with considerable input from human factors and plant operations experts. Most importantly, and different from severe accident management strategies for other plants, the AP1000 SAMGs do not require diagnosis of the location of the core (i.e., whether reactor vessel failure has occurred). This is a fundamental consequence of the AP1000 In-Vessel Retention approach, which allows severe accident management to be based on fundamental principles (e.g. provide coolant as close as possible to the core) that do not change during a specific event. This eliminates the need for one of the more difficult diagnostic requirements, since reactor vessel failure does not directly relate to any measurable plant parameter, and differs from other designs in that an engineered failure of the pressure vessel' (e.g. core catcher) is never required. (authors)« less

Utilizing HDTV as Data for Space Flight

NASA Technical Reports Server (NTRS)

Grubbs, Rodney; Lindblom, Walt

2006-01-01

In the aftermath of the Space Shuttle Columbia accident February 1, 2003, the Columbia Accident Investigation Board recognized the need for better video data from launch, on-orbit, and landing to assess the status and safety of the shuttle orbiter fleet. The board called on NASA to improve its imagery assets and update the Agency s methods for analyzing video. This paper will feature details of several projects implemented prior to the return to flight of the Space Shuttle, including an airborne HDTV imaging system called the WB-57 Ascent Video Experiment, use of true 60 Hz progressive scan HDTV for ground and airborne HDTV camera systems, and the decision to utilize a wavelet compression system for recording. This paper will include results of compression testing, imagery from the launch of STS-114, and details of how commercial components were utilized to image the shuttle launch from an aircraft flying at 400 knots at 60,000 feet altitude. The paper will conclude with a review of future plans to expand on the upgrades made prior to return to flight.

Cement dust exposition and bronchioalveolitis. A case report.

PubMed

Soto-de la Fuente, Andrés Eduardo; Méndez-Vargas, María Martha; Báez-Revueltas, Fabiola Berenice; Soto-Vera, Eduardo Andrés

2015-01-01

The goal of the current investigation was to report an unusual case of a worker acutely exposed to big amounts of cement dust. This exposure caused chemical bronchioalveolitis and dermatitis due to chromium contact. This person suffered the exposure when a cement deposit exploded at work. This exposed the worker to big amounts of cement dust. After the accident, the individual suffered dyspnea and bilateral basal pulmonary crackles. The subject also presented an atypical restrictive pattern, which could also be seen on X-rays as 1/1 q/q images of the classification of 2000 of the International Labour Organization (ILO), and a bulging of a pulmonary artery. A restrictive pattern pure atypical was observed, and arterial blood gas with hipoxemia. A treatment with steroids was prescribed and the worker showed some improvement. There is high risk of developing pulmonary fibrosis with the progressive evolution in stages of the bronchioalveolitis, even when the subject is isolated. Therefore, it would be very convenient to create a specialized medical center where workers that have this kind of accidents can have the proper care by qualified personnel.

Design rules for quantum imaging devices: experimental progress using CMOS single-photon detectors

NASA Astrophysics Data System (ADS)

Charbon, Edoardo; Gunther, Neil J.; Boiko, Dmitri L.; Beretta, Giordano B.

2006-08-01

We continue our previous program1 where we introduced a set of quantum-based design rules directed at quantum engineers who design single-photon quantum communications and quantum imaging devices. Here, we report on experimental progress using SPAD (single photon avalanche diode) arrays of our design and fabricated in CMOS (complementary metal oxide semiconductor) technology. Emerging high-resolution imaging techniques based on SPAD arrays have proven useful in a variety of disciplines including bio-fluorescence microscopy and 3D vision systems. They have also been particularly successful for intra-chip optical communications implemented entirely in CMOS technology. More importantly for our purposes, a very low dark count allows SPADs to detect rare photon events with a high dynamic range and high signal-to-noise ratio. Our CMOS SPADs support multi-channel detection of photon arrivals with picosecond accuracy, several million times per second, due to a very short detection cycle. The tiny chip area means they are suitable for highly miniaturized quantum imaging devices and that is how we employ them in this paper. Our quantum path integral analysis of the Young-Afshar-Wheeler interferometer showed that Bohr's complementarity principle was not violated due the previously overlooked effect of photon bifurcation within the lens--a phenomenon consistent with our quantum design rules--which accounts for the loss of which-path information in the presence of interference. In this paper, we report on our progress toward the construction of quantitative design rules as well as some proposed tests for quantum imaging devices using entangled photon sources with our SPAD imager.

Progressing from programmatic to discovery research: a case example with the overjustification effect.

PubMed

Roane, Henry S; Fisher, Wayne W; McDonough, Erin M

2003-01-01

Scientific research progresses along planned (programmatic research) and unplanned (discovery research) paths. In the current investigation, we attempted to conduct a single-case evaluation of the overjustification effect (i.e., programmatic research). Results of the initial analysis were contrary to the overjustification hypothesis in that removal of the reward contingency produced an increase in responding. Based on this unexpected finding, we conducted subsequent analyses to further evaluate the mechanisms underlying these results (i.e., discovery research). Results of the additional analyses suggested that the reward contingency functioned as punishment (because the participant preferred the task to the rewards) and that withdrawal of the contingency produced punishment contrast.

Progressing from programmatic to discovery research: a case example with the overjustification effect.

PubMed Central

Roane, Henry S; Fisher, Wayne W; McDonough, Erin M

2003-01-01

Scientific research progresses along planned (programmatic research) and unplanned (discovery research) paths. In the current investigation, we attempted to conduct a single-case evaluation of the overjustification effect (i.e., programmatic research). Results of the initial analysis were contrary to the overjustification hypothesis in that removal of the reward contingency produced an increase in responding. Based on this unexpected finding, we conducted subsequent analyses to further evaluate the mechanisms underlying these results (i.e., discovery research). Results of the additional analyses suggested that the reward contingency functioned as punishment (because the participant preferred the task to the rewards) and that withdrawal of the contingency produced punishment contrast. PMID:12723865

High-dose neutron detector project update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menlove, Howard Olsen; Henzlova, Daniela

These are the slides for a progress review meeting by the sponsor. This is an update on the high-dose neutron detector project. In summary, improvements in both boron coating and signal amplification have been achieved; improved boron coating materials and procedures have increased efficiency by ~ 30-40% without the corresponding increase in the detector plate area; low dead-time via thin cell design (~ 4 mm gas gaps) and fast amplifiers; prototype PDT 8” pod has been received and testing is in progress; significant improvements in efficiency and stability have been verified; use commercial PDT 10B design and fabrication to obtainmore » a faster path from the research to practical high-dose neutron detector.« less

Feasibility of Whole-Body Functional Mouse Imaging Using Helical Pinhole SPECT

PubMed Central

Metzler, Scott D.; Vemulapalli, Sreekanth; Jaszczak, Ronald J.; Akabani, Gamal; Chin, Bennett B.

2010-01-01

Purpose Detailed in vivo whole-body biodistributions of radiolabeled tracers may characterize the longitudinal progression of disease, and changes with therapeutic interventions. Small-animal imaging in mice is particularly attractive due to the wide array of well characterized genetically and surgically created models of disease. Single Photon Emission Computed Tomography (SPECT) imaging using pinhole collimation provides high resolution and sensitivity, but conventional methods using circular acquisitions result in severe image truncation and incomplete sampling of data which prevent the accurate determination of whole-body radiotracer biodistributions. This study describes the feasibility of helical acquisition paths to mitigate these effects. Procedures Helical paths of pinhole apertures were implemented using an external robotic stage aligned with the axis of rotation (AOR) of the scanner. Phantom and mouse scans were performed using helical paths and either circular or bi-circular orbits at the same radius of rotation (ROR). The bi-circular orbits consisted of two 360-degree scans separated by an axial shift to increase the axial field of view (FOV) and to improve the complete-sampling properties. Results Reconstructions of phantoms and mice acquired with helical paths show good image quality and are visually free of both truncation and axial-blurring artifacts. Circular orbits yielded reconstructions with both artifacts and a limited effective FOV. The bi-circular scans enlarged the axial FOV, but still suffered from truncation and sampling artifacts. Conclusions Helical paths can provide complete sampling data and large effective FOV, yielding 3D full-body in vivo biodistributions while still maintaining a small distance from the aperture to the object for good sensitivity and resolution. PMID:19521736

Argillite And Crystalline Disposal Research: Accomplishments And Path-Forward.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, Kevin A.; Jove-Colon, Carlos F.; Wang, Yifeng

The intention of this document is to provide a path-forward for research and development (R&D) for two host rock media-specific (argillite and crystalline) disposal research work packages within the Used Fuel Disposition Campaign (UFDC). The two work packages, Argillite Disposal R&D and Crystalline Disposal R&D, support the achievement of the overarching mission and objectives of the Department of Energy Office of Nuclear Energy Fuel Cycle Technologies Program. These two work packages cover many of the fundamental technical issues that will have multiple implications to other disposal research work packages by bridging knowledge gaps to support the development of the safetymore » case. The path-forward begins with the assumption of target dates that are set out in the January 2013 DOE Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (http://energy.gov/downloads/strategy-management-and-disposal-used-nuclear-fuel-and-high-levelradioactive- waste). The path-forward will be maintained as a living document and will be updated as needed in response to available funding and the progress of multiple R&D tasks in the Used Fuel Disposition Campaign and the Fuel Cycle Technologies Program. This path forward is developed based on the report of “Used Fuel Disposition Campaign Disposal Research and Development Roadmap (FCR&D-USED- 2011-000065 REV0)” (DOE, 2011). This document delineates the goals and objectives of the UFDC R&D program, needs for generic disposal concept design, and summarizes the prioritization of R&D issues.« less

Human-like robots as platforms for electroactive polymers (EAP)

NASA Astrophysics Data System (ADS)

Bar-Cohen, Yoseph

2008-03-01

Human-like robots, which have been a science fiction for many years, are increasingly becoming an engineering reality thanks to many technology advances in recent years. Humans have always sought to imitate the human appearance, functions and intelligence and as the capability progresses they may become our household appliance or even companion. Biomimetic technologies are increasingly becoming common tools to support the development of such robots. As artificial muscles, electroactive polymers (EAP) are offering important actuation capability for making such machines lifelike. The current limitations of EAP are hampering the possibilities that can be adapted in such robots but progress is continually being made. As opposed to other human made machines and devices, this technology raises various questions and concerns that need to be addressed. These include the need to prevent accidents, deliberate harm, or their use in crimes. In this paper the state-of-the-art and the challenges will be reviewed.

Fukushima Daiichi unit 1 uncertainty analysis--Preliminary selection of uncertain parameters and analysis methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardoni, Jeffrey N.; Kalinich, Donald A.

2014-02-01

Sandia National Laboratories (SNL) plans to conduct uncertainty analyses (UA) on the Fukushima Daiichi unit (1F1) plant with the MELCOR code. The model to be used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). However, that study only examined a handful of various model inputs and boundary conditions, and the predictions yielded only fair agreement with plant data and current release estimates. The goal of this uncertainty study is to perform a focused evaluation of uncertainty in core melt progression behavior and its effect on keymore » figures-of-merit (e.g., hydrogen production, vessel lower head failure, etc.). In preparation for the SNL Fukushima UA work, a scoping study has been completed to identify important core melt progression parameters for the uncertainty analysis. The study also lays out a preliminary UA methodology.« less

Quantifying the dilution of the radiocesium contamination in Fukushima coastal river sediment (2011-2015)

NASA Astrophysics Data System (ADS)

Evrard, Olivier; Laceby, J. Patrick; Onda, Yuichi; Wakiyama, Yoshifumi; Jaegler, Hugo; Lefèvre, Irène

2016-10-01

Fallout from the Fukushima Dai-ichi nuclear power plant accident resulted in a 3000-km2 radioactive contamination plume. Here, we model the progressive dilution of the radiocesium contamination in 327 sediment samples from two neighboring catchments with different timing of soil decontamination. Overall, we demonstrate that there has been a ~90% decrease of the contribution of upstream contaminated soils to sediment transiting the coastal plains between 2012 (median - M - contribution of 73%, mean absolute deviation - MAD - of 27%) and 2015 (M 9%, MAD 6%). The occurrence of typhoons and the progress of decontamination in different tributaries of the Niida River resulted in temporary increases in local contamination. However, the much lower contribution of upstream contaminated soils to coastal plain sediment in November 2015 demonstrates that the source of the easily erodible, contaminated material has potentially been removed by decontamination, diluted by subsoils, or eroded and transported to the Pacific Ocean.

Helicopter synthetic vision based DVE processing for all phases of flight

NASA Astrophysics Data System (ADS)

O'Brien, Patrick; Baughman, David C.; Wallace, H. Bruce

2013-05-01

Helicopters experience nearly 10 times the accident rate of fixed wing platforms, due largely to the nature of their mission, frequently requiring operations in close proximity to terrain and obstacles. Degraded visual environments (DVE), including brownout or whiteout conditions generated by rotor downwash, result in loss of situational awareness during the most critical phase of flight, and contribute significantly to this accident rate. Considerable research into sensor and system solutions to address DVE has been conducted in recent years; however, the promise of a Synthetic Vision Avionics Backbone (SVAB) extends far beyond DVE, enabling improved situational awareness and mission effectiveness during all phases of flight and in all visibility conditions. The SVAB fuses sensor information with high resolution terrain databases and renders it in synthetic vision format for display to the crew. Honeywell was awarded the DARPA MFRF Technical Area 2 contract in 2011 to develop an SVAB1. This work includes creation of a common sensor interface, development of SVAB hardware and software, and flight demonstration on a Black Hawk helicopter. A "sensor agnostic" SVAB allows platform and mission diversity with efficient upgrade path, even while research continues into new and improved sensors for use in DVE conditions. Through careful integration of multiple sources of information such as sensors, terrain and obstacle databases, mission planning information, and aircraft state information, operations in all conditions and phases of flight can be enhanced. This paper describes the SVAB and its functionality resulting from the DARPA contract as well as Honeywell RD investment.

Explosion/Blast Dynamics for Constellation Launch Vehicles Assessment

NASA Technical Reports Server (NTRS)

Baer, Mel; Crawford, Dave; Hickox, Charles; Kipp, Marlin; Hertel, Gene; Morgan, Hal; Ratzel, Arthur; Cragg, Clinton H.

2009-01-01

An assessment methodology is developed to guide quantitative predictions of adverse physical environments and the subsequent effects on the Ares-1 crew launch vehicle associated with the loss of containment of cryogenic liquid propellants from the upper stage during ascent. Development of the methodology is led by a team at Sandia National Laboratories (SNL) with guidance and support from a number of National Aeronautics and Space Administration (NASA) personnel. The methodology is based on the current Ares-1 design and feasible accident scenarios. These scenarios address containment failure from debris impact or structural response to pressure or blast loading from an external source. Once containment is breached, the envisioned assessment methodology includes predictions for the sequence of physical processes stemming from cryogenic tank failure. The investigative techniques, analysis paths, and numerical simulations that comprise the proposed methodology are summarized and appropriate simulation software is identified in this report.

Neutron Characterization of Encapsulated ATF-1/LANL-1 Mockup Fuel Capsules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vogel, Sven C.; Borges, Nicholas Paul; Losko, Adrian Simon

Twenty pellets of mock-up accident tolerant fuels UN-U3Si5 were produced at LANL and loaded in two rodlet/capsule assemblies. Tomographic imaging and diffraction measurements were performed to characterize these samples at the Flight-Path 5 and HIPPO beam lines at LANSCE/LANL between November 2016 and January 2017 as well as in August 2017. The entire ~10 cm long, ~1 cm diameter fuel volume could be characterized, however due to time constraints only 2 mm slices in 4mm increments were characterized with neutron diffraction and a 28mm subset of the entire sample was characterized with energy-resolved neutron imaging. The double encapsulation of themore » fuel into two steel containers does not pose a problem for the neutron analysis and the methods could be applied to enriched as well irradiated fuels.« less

Parametric and experimentally informed BWR Severe Accident Analysis Utilizing FeCrAl - M3FT-17OR020205041

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ott, Larry J.; Howell, Michael; Robb, Kevin R.

Iron-chromium-aluminum (FeCrAl) alloys are being considered as advanced fuel cladding concepts with enhanced accident tolerance. At high temperatures, FeCrAl alloys have slower oxidation kinetics and higher strength compared with zirconium-based alloys. FeCrAl could be used for fuel cladding and spacer or mixing vane grids in light water reactors and/or as channel box material in boiling water reactors (BWRs). There is a need to assess the potential gains afforded by the FeCrAl accident-tolerant-fuel (ATF) concept over the existing zirconium-based materials employed today. To accurately assess the response of FeCrAl alloys under severe accident conditions, a number of FeCrAl properties and characteristicsmore » are required. These include thermophysical properties as well as burst characteristics, oxidation kinetics, possible eutectic interactions, and failure temperatures. These properties can vary among different FeCrAl alloys. Oak Ridge National Laboratory has pursued refined values for the oxidation kinetics of the B136Y FeCrAl alloy (Fe-13Cr-6Al wt %). This investigation included oxidation tests with varying heating rates and end-point temperatures in a steam environment. The rate constant for the low-temperature oxidation kinetics was found to be higher than that for the commercial APMT FeCrAl alloy (Fe-21Cr-5Al-3Mo wt %). Compared with APMT, a 5 times higher rate constant best predicted the entire dataset (root mean square deviation). Based on tests following heating rates comparable with those the cladding would experience during a station blackout, the transition to higher oxidation kinetics occurs at approximately 1,500°C. A parametric study varying the low-temperature FeCrAl oxidation kinetics was conducted for a BWR plant using FeCrAl fuel cladding and channel boxes using the MELCOR code. A range of station blackout severe accident scenarios were simulated for a BWR/4 reactor with Mark I containment. Increasing the FeCrAl low-temperature oxidation rate constant (3 times and 10 times that of the rate constant for APMT) had a negligible impact on the early stages of the accident and minor impacts on the accident progression after the first relocation of the fuel. At temperatures below 1,500°C, increasing the rate constant for APMT by a factor of 10 still resulted in only minor FeCrAl oxidation. In general, the gains afforded by the FeCrAl enhanced ATF concept with respect to accident sequence timing and combustible gas generation are consistent with previous efforts. Compared with the traditional Zircaloy-based cladding and channel box system, the FeCrAl concept could provide a few extra hours of time for operators to take mitigating actions and/or for evacuations to take place. A coolable core geometry is retained longer, enhancing the ability to stabilize an accident. For example, a station blackout was simulated in which cooling water injection was lost 36 hours after shutdown. The timing to first fuel relocation was delayed by approximately 5 h for the FeCrAl ATF concept compared with that of the traditional Zircaloy-based cladding and channel box system.« less

Social inequalities in the face of scientific and technological development: an antinomy or an historic problem?

PubMed

Delgado, Guilherme Costa

2017-07-01

This paper aims to conduct a conceptual analysis of the relationship between scientific and technical progress and social equality, or the reduction of inequalities. We examine this relationship by drawing on three theoretical perspectives: 1) ethical economics, championed by classical economic thinkers and centered on utilitarian self-interest, 2) Mainstream theories of economic development espousing the endogenous link between labor productivity growth and technical progress, 3) the critique of theories of economic development that emerged in the second half of the twentieth century, including Celso Furtado's critique of the theory of underdevelopment, emphasizing the prevalence of egalitarian tendencies, and ecological economics, which suggest alternative paths to those set by "classical" theories of development. The fundamental antinomy posed by the title of this article, characterized by an intrinsic contradiction between technical progress and social equality, strictly presupposes the ethical economics perspective, dominated by the social relations that constitute the "social order".

Progress toward Topology Optimization (TO) for Additive Manufacturing (AM) and Fatigue

DTIC Science & Technology

2017-06-15

traditional manufacturing processes due to cost, tool-path constraints, or operator limitations. While AM significantly widens the design space for TO... manufacturing constraints and limitations remain1 and should be addressed in the design process. An objective of this work is to consider manufacturing ...account for AM limitations within the design . The limitations of interest in this work are the production of support material and enclosed pores. Both

Career Progression Systems in the Internal Labor Market of the Foodservice Industry and the Role of the National Restaurant Association. Final Report.

ERIC Educational Resources Information Center

Smith, Leonard; Pezzullo, Caroline

The lack of visible career paths was universally recognized as a major factor leading to the extraordinarily high rate of turnover and absenteeism in the foodservice industry. The report evaluates the potential of a National Trade Association as a vehicle for improvements in this area and focuses on National Restaurant Association (NRA) efforts in…

Emerging immunotherapies for rheumatoid arthritis

PubMed Central

Reynolds, Gary; Cooles, Faye AH; Isaacs, John D; Hilkens, Catharien MU

2014-01-01

Novel treatments in development for rheumatoid arthritis target 3 broad areas: cytokines, cells, and signaling pathways. Therapies from each domain share common advantages (for example previously demonstrated efficacy, potential long-term immunomodulation, and oral administration respectively) that have stimulated research in each area but also common obstacles to their development. In this review recent progress in each area will be discussed alongside the factors that have impeded their path to clinical use. PMID:24535556

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhinefrank, Kenneth; Lamb, Bradford; Prudell, Joseph

This Project aims to satisfy objectives of the DOE’s Water Power Program by completing a system detailed design (SDD) and other important activities in the first phase of a utility-scale grid-connected ocean wave energy demonstration. In early 2012, Columbia Power (CPwr) had determined that further cost and performance optimization was necessary in order to commercialize its StingRAY wave energy converter (WEC). CPwr’s progress toward commercialization, and the requisite technology development path, were focused on transitioning toward a commercial-scale demonstration. This path required significant investment to be successful, and the justification for this investment required improved annual energy production (AEP) andmore » lower capital costs. Engineering solutions were developed to address these technical and cost challenges, incorporated into a proposal to the US Department of Energy (DOE), and then adapted to form the technical content and statement of project objectives of the resulting Project (DE-EE0005930). Through Project cost-sharing and technical collaboration between DOE and CPwr, and technical collaboration with Oregon State University (OSU), National Renewable Energy Lab (NREL) and other Project partners, we have demonstrated experimentally that these conceptual improvements have merit and made significant progress towards a certified WEC system design at a selected and contracted deployment site at the Wave Energy Test Site (WETS) at the Marine Corps Base in Oahu, HI (MCBH).« less

Speciation analysis of I-127,129 in the crop field soil contaminated by the Fukushima Dai-ichi nuclear power plant accident with newly developed chemical separation techniques

NASA Astrophysics Data System (ADS)

Honda, Maki; Matsuzaki, Hiroyuki; Saito, Takumi; Nagai, Hisao

2014-05-01

In previous study, we investigated the depth profile of the accident derived I-129 and downward migration speed in soils of near-field of Fukushima Dai-ichi Nuclear Power Plant, including crop fields and man-made fields. I-129 in soil was measured by AMS and stable iodine (I-127) was measured by ICP-MS at MALT (Micro Analysis Laboratory, Tandem accelerator), The University of Tokyo. It was found that I-129 was concentrated near surface but distributed deeper compared with Cs-137. It was also found that I-129 seems to move downward more quickly than Cs-137. To investigate the adsorption mechanism and the elemental process of migration of the accident derived I-129 in soil, it is important to know what kind of component the I-129 combines with. Recent studies on the X-ray absorption fine structure (XAFS), especially near edge structure (XANES), reported that the stable iodine (I-127) in soil existed as an organic component. However, it had not yet been proved that it was also the case with the accident derived I-129 because it had been incorporated in the soil system only recently and the abundance of I-129 in soil was more than 8 orders of magnitude smaller than sub-ppm level stable iodine (I-127). In this study a progressive sequential extraction method including the dialysis and the dynamic headspace method was newly developed to obtain only the iodine sticking to the soil organic component. The stable iodine can be quantified by direct analysis of the fraction and I-129 can be quantified by AMS method of the fraction added with carrier. The fraction of the organic component for I-127 and I-129 can be evaluated respectively by comparing with the other fraction and/or with the total concentration obtained by the bulk analysis (e.g. by the pyrohydrolysis).

Geometric and Road Environmental Effects against Total Number of Traffic Accidents in Kendari

NASA Astrophysics Data System (ADS)

Kurdin, M. Akbar; Welendo, La; Annisa, Nur

2017-05-01

From the large number of traffic accidents that occurred, the carrying of Kendari as the biggest contributor to accidents in the Southeast. The number of accidents in Kendari row since 2011 was recorded at 18 accidents due to the influence of geometric road, in 2012 registered at 13 accident and in 2013 amounted to 6 accidents, with accident data because of the influence Geometric recorded for 3 consecutive years the biggest contributor to accidents because of the influence of geometric is Abeli districts. This study aimed to determine the road which common point of accident-prone (Black spot) in Kecamatan Abeli as accident-prone areas in Kendari, analyze the influence of geometric and road environment against accidents on roads in Kecamatan Abeli, provide alternative treatment based on the causes of accidents on the location of the accident-prone points (blackspot) to reduce the rate of traffic accidents. From the results of a study of 6 curve the accident-prone locations, that the curve I, II, and VI is the “Black Spot” influenced by the amount and condition of traffic accidents, while at the curve II, a traffic accident that occurred also be caused by unsafe geometric where the type of geometric should be changed from Spiral-Spiral type to Spiral-Circle-Spiral type. This indicates geometric effect on the number of accidents.

Resource recycling technique of abandoned TNT-RDX-AL mixed explosive

NASA Astrophysics Data System (ADS)

Chen, Siyang; Ding, Yukui

2017-08-01

TNT-RDX-AL mixed explosive is a kind of high energy mixed explosive. It has the detonation characteristics even when reaching the scrapping standard. Inappropriate disposal often causes serious accident. Employing the resource recycling technique, the abandoned TNT-RDX-AL mixed explosive can be recycled. This paper summarized the progress of recycling of abandoned mixed explosive. What's more, three kinds of technological process of resource recycling abandoned TNT-RDX-AL mixed explosives are introduced. The author analysis of the current recovery processes and provided a reference for the recycling of the other same type explosive.

[Experience of Regional Vascular Centre in assisting patients with severe cerebrovascular accidents in Novosibirsk].

PubMed

Doronin, B M; Marushak, A A; Popova, T F; Gribacheva, I A; Petrova, E V

2016-01-01

The analysis of the work of the neurological department of the Novosibirsk regional vascular center of City Clinical Hospital #1 for the period from 2013 to 2015 was done. We analyzed the annual reports of the regional vascular center, dynamics of cerebrovascular disease patterns, lethality, about the provision of medical care to patients with stroke, the use of high-tech methods of diagnosis and treatment. Ascertain the progress achieved and the perspectives of further improving the quality of care to patients with stroke due to wider use of methods of rehabilitation in the acute stage of stroke.

[Trampoline therapy with brain-injured children and adolescents (author's transl)].

PubMed

Erichsen, H; Böttcher, H

1976-05-01

Trampoline therapy is a useful part of the medical rehabilitation treatment of brain-injured children and adolescents, if the basic principles of accident prevention are observed. The therapy should only consist of systematically organised exercise series and be carried out by adequately trained sport teachers, medical paedagogues or physical therapists. In the "Jugendwerk Gailingen" an improvement of the standing balance and movement co-ordination was achieved in more than 20 patients with hemiparesis and tetraparesis. Only little progress was achieved in atactic and athetoid patients. It is important to stress the positive psychological effects of the trampoline therapy.

Restoration of Function With Acupuncture Following Severe Traumatic Brain Injury: A Case Report.

PubMed

Wolf, Jacob; Sparks, Linda; Deng, Yong; Langland, Jeffrey

2015-11-01

This case report illustrates the improvement of an acupuncture-treated patient who incurred a severe traumatic brain injury (TBI) from a snowboarding accident. Over 4 years, the patient progressed from initially not being able to walk, having difficulty with speech, and suffering from poor eyesight to where he has now regained significant motor function, speech, and vision and has returned to snowboarding. A core acupuncture protocol plus specific points added to address the patient's ongoing concerns was used. This case adds to the medical literature by demonstrating the potential role of acupuncture in TBI treatment.

Using chemical, hydrologic, and age dating analysis to delineate redox processes and flow paths in the riparian zone of a glacial outwash aquifer‐stream system

USGS Publications Warehouse

Puckett, Larry J.; Cowdery, Timothy K.; McMahon, Peter B.; Tornes, Lan H.; Stoner, Jeffrey D.

2002-01-01

A combination of chemical and dissolved gas analyses, chlorofluorocarbon age dating, and hydrologic measurements were used to determine the degree to which biogeochemical processes in a riparian wetland were responsible for removing NO3−from groundwaters discharging to the Otter Tail River in west central Minnesota. An analysis of river chemistry and flow data revealed that NO3− concentrations in the river increased in the lower half of the 8.3 km study reach as the result of groundwater discharge to the river. Groundwater head measurements along a study transect through the riparian wetland revealed a zone of groundwater discharge extending out under the river. On the basis of combined chemical, dissolved gas, age date, and hydrologic results, it was determined that water chemistry under the riparian wetland was controlled largely by upgradient groundwaters that followed flow paths up to 16 m deep and discharged under the wetland, creating a pattern of progressively older, more chemically reduced, low NO3− water the farther one progressed from the edge of the wetland toward the river. These findings pose challenges for researchers investigating biogeochemical processes in riparian buffer zones because the progressively older groundwaters entered the aquifer in earlier years when less NO3− fertilizer was being used. NO3− concentrations originally present in the groundwater had also decreased in the upgradient aquifer as a result of denitrification and progressively stronger reducing conditions there. The resulting pattern of decreasing NO3− concentrations across the riparian zone may be incorrectly interpreted as evidence of denitrification losses there instead of in the upgradient aquifer. Consequently, it is important to understand the hydrogeologic setting and age structure of the groundwaters being sampled in order to avoid misinterpreting biogeochemical processes in riparian zones.

Issues for Future Nuclear Arms Control

NASA Astrophysics Data System (ADS)

Davis, Jay

2011-04-01

Ratification of the New START treaty may open the door to a path of progressive negotiations that could lead to systematic reduction of the numbers of deployed and reserve nuclear weapons. Those negotiations will require more than merely resolving technical, operational and policy questions. Their success will also demand adding successively larger numbers of partners and the building of trust among parties who have not been involved in such agreements before. At some point, questions of conventional arms limitations and larger confidence building steps will inevitably arise. Jay Davis, who last year chaired an APS/POPA study of technology issues for future nuclear arms control agreements, will outline the path, opportunities, and obstacles that lie ahead. Davis was an UNSCOM inspector in Iraq after the First Gulf War and the first director of the Defense Threat Reduction Agency.

Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling

PubMed Central

Woo, Sang-Mi; Park, Sunju; Shin, Yong Cheol; Ko, Seong-Gyu

2014-01-01

Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path. PMID:24976685

Vulnerability assessment of chemical industry facilities in South Korea based on the chemical accident history

NASA Astrophysics Data System (ADS)

Heo, S.; Lee, W. K.; Jong-Ryeul, S.; Kim, M. I.

2016-12-01

The use of chemical compounds are keep increasing because of their use in manufacturing industry. Chemical accident is growing as the consequence of the chemical use increment. Devastating damages from chemical accidents are far enough to aware people's cautious about the risk of the chemical accident. In South Korea, Gumi Hydrofluoric acid leaking accident triggered the importance of risk management and emphasized the preventing the accident over the damage reducing process after the accident occurs. Gumi accident encouraged the government data base construction relate to the chemical accident. As the result of this effort Chemical Safety-Clearing-house (CSC) have started to record the chemical accident information and damages according to the Harmful Chemical Substance Control Act (HCSC). CSC provide details information about the chemical accidents from 2002 to present. The detail informations are including title of company, address, business type, accident dates, accident types, accident chemical compounds, human damages inside of the chemical industry facilities, human damage outside of the chemical industry facilities, financial damages inside of the chemical industry facilities, and financial damages outside of the chemical industry facilities, environmental damages and response to the chemical accident. Collected the chemical accident history of South Korea from 2002 to 2015 and provide the spatial information to the each accident records based on their address. With the spatial information, compute the data on ArcGIS for the spatial-temporal analysis. The spatial-temporal information of chemical accident is organized by the chemical accident types, damages, and damages on environment and conduct the spatial proximity with local community and environmental receptors. Find the chemical accident vulnerable area of South Korea from 2002 to 2015 and add the vulnerable area of total period to examine the historically vulnerable area from the chemical accident in South Korea.

Subjective health legacy of the Chornobyl accident: a comparative study of 19-year olds in Kyiv

PubMed Central

2009-01-01

Background Since the Chornobyl accident in 1986, the physical health of exposed children in Ukraine has been monitored, but their perceived health has not been studied. This study examines health perceptions of Ukrainian adolescents exposed to radioactive fallout in utero or as infants, and the epidemiologic and Chornobyl-related influences on self-reported health. Method We assessed three groups of 19-year olds in Kyiv: 262 evacuees from contaminated areas near the plant; 261 classmate controls; and 325 population-based controls. The evacuees and classmates were previously assessed at age 11. Structured interviews were conducted with the adolescents and their mothers (N = 766), followed by general physical examinations (N = 722) and blood tests (N = 707). Proportional odds logistic regression and multi-group path analysis were the major statistical tests. Results The examination and blood test results were similar across groups except for a significantly elevated rate of thyroid enlargement found by palpation in evacuees (17.8%) compared former classmates (8.7%) and population-based controls (8.0%). In addition, four evacuees and one population control had had a thyroidectomy. Compared to controls, the evacuees rated their health the least positively and reported more medically diagnosed illnesses during the 5 years preceding the interview, particularly thyroid disease, migraine headache, and vascular dystony. The consistent risk factors (p < 0.001) for these subjective health reports were evacuee status, female gender, multiple hospitalizations, and health risk perception regarding Chornobyl. All three groups of mothers rated their children's health more negatively than the adolescents themselves, and maternal ratings were uniquely associated with the adolescents' health reports in the adjusted models. In the longitudinal evacuee and classmate subsamples, path analysis showed that mothers' health ratings when the children were age 11 predicted their later evaluations which in turn were associated with the adolescent self-reports. Conclusion The more negative self-evaluations of the evacuees were linked to a number of risk factors, including multiple hospitalizations, health risk perceptions, and epidemiologic risk factors. The increased rate of thyroid cancer and other diagnoses no doubt contributed to the evacuees' less positive subjective health. The strong effect of the mothers' perceptions argues in favor of developing risk communication programs for families rather than for mothers or adolescents as separate target groups. PMID:19919706

Optical effects produced by running onboard engines of low-earth-orbit spacecraft

NASA Astrophysics Data System (ADS)

Beletskiy, A. B.; Mihalev, A. V.; Hahinov, V. V.; Lebedev, V. P.

2016-12-01

This paper presents results of optical observations made during Radar-Progress Experiment performed on April 17, 2013 and July 30, 2014 after approach-correction engines (ACE) of Progress M-17M and Progress M-23M cargo spacecraft in the thermosphere had been started. A region of enhanced emission intensity was recorded during engine operation. This may have been related to the scatter of twilight solar emission along the cargo spacecraft exhaust and to the emergence of additional atomic oxygen [OI] emission at 630 nm. The maximum dimension of the observed emission region was ~330-350 km and ~250-270 km along and across the orbit respectively. For the first time after ACE had been started, an expansion rate of emission region was ~ 7 and ~ 3.5 km/s along and across the orbit respectively. The maximum intensity of the disturbance area for Progress M-17M is estimated as ~40-60 R at 2 nm. Progress M-23M Space Experiment recorded a minor disturbance of atmospheric [OI] 630.0 nm emissions, both in near and in far cargo spacecraft flight paths, which might have been associated with the ACE exhaust gas injection.

2014 Trans-Atlantic Research and Development Interchange ...

EPA Pesticide Factsheets

The Trans-Atlantic Research and Development Interchange on Sustainability (TARDIS) has been bringing together a select group of scientists and engineers for in-depth discussions on sustainability on a bi-annual basis since 2004. TARDIS 2014 included twenty eight individuals from across the globe discussing issues related to progress towards sustainability. The discussion included policies, technologies, societal structure and norms, business practices and culture, and time-frames. As discussed later, the focus was on four questions: (1) what progress has been accomplished in sustainability? (2) why has there not been more progress in moving societies towards sustainability? (3) what are the road-blocks to progress towards sustainability? (4) what are the policies, technologies, and other changes that are needed to make further progress towards sustainability? One salient conclusion from TARDIS 2014 is that while sustainability has entered mainstream thinking, significant social, economic, technological, and business barriers remain to further progress towards a sustainable path as discussed throughout this report. The Trans-Atlantic Research and Development Interchange on Sustainability is a bi-annual workshop alternatively held in the United States and Austria. The purpose is to bring the best thinkers from across the globe to discuss, explore, and clarify major issues related to sustainability. A report summarizing teh finding and discussions is prepared and d

Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI).

PubMed

Nalls, Mike A; Keller, Margaux F; Hernandez, Dena G; Chen, Lan; Stone, David J; Singleton, Andrew B

2016-01-01

The Parkinson's Progression Marker Initiative is an international multicenter study whose main goal is investigating markers for Parkinson's disease (PD) progression as part of a path to a treatment for the disease. This manuscript describes the baseline genetic architecture of this study, providing not only a catalog of disease-linked variants and mutations, but also quantitative measures with which to adjust for population structure. Three hundred eighty-three newly diagnosed typical PD cases, 65 atypical PD and 178 healthy controls, from the Parkinson's Progression Marker Initiative study have been genotyped on the NeuroX or Immunochip arrays. These data are freely available to all researchers interested in pursuing PD research within the Parkinson's Progression Marker Initiative. The Parkinson's Progression Marker Initiative represents a study population with low genetic heterogeneity. We recapitulate known PD associations from large-scale genome-wide association studies and refine genetic risk score models for PD predictability (area under the curve, ∼0.74). We show the presence of six LRRK2 p.G2019S and nine GBA p.N370S mutation carriers. The Parkinson's Progression Marker Initiative study and its genetic data are useful in studies of PD biomarkers. The genetic architecture described here will be useful in the analysis of myriad biological and clinical traits within this study. © 2015 International Parkinson and Movement Disorder Society.

Valve and dash-pot assembly

DOEpatents

Chang, Shih-Chih

1986-01-01

A dash-pot valve comprising a cylinder submerged in the fluid of a housing and having a piston attached to a plunger projecting into the path of closing movement of a pivotal valve member. A vortex chamber in said cylinder is provided with tangentially directed inlets to generate vortex flow upon retraction of said plunger and effect increasing resistance against said piston to progressively retard the closing rate of said valve member toward its seat.

Improved valve and dash-pot assembly

DOEpatents

Chang, S.C.

1985-04-23

A dash-pot valve comprises a cylinder submerged in the fluid of a housing and have a piston attached to a plunger projecting into the path of closing movement of a pivotal valve member. A vortex chamber in said cylinder is provided with targentially directed inlets to generate vortex flow upon retraction of said plunger and effect increasing resistance against said piston to progressively retard the closing rate of said valve member toward its seat.

Seismic Attenuation, Event Discrimination, Magnitude and Yield Estimation, and Capability Analysis

DTIC Science & Technology

2011-09-01

waves are subject to path-dependent variations in amplitudes. We see geographic similarities between the crustal shear-wave attenuation and the...either Sn or Lg depending on tectonic region, distance, and frequency. Over the past year, we have made great progress on the calibration of surface...between the crustal shear-wave attenuation and the results from the coda attenuation. Calibration of coda in the Middle East and other areas is

49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

Code of Federal Regulations, 2014 CFR

2014-10-01

... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's official public docket files of its accident investigations, or its computerized accident database(s) shall be...

49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

Code of Federal Regulations, 2012 CFR

2012-10-01

... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's official public docket files of its accident investigations, or its computerized accident database(s) shall be...

49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

Code of Federal Regulations, 2010 CFR

2010-10-01

... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's official public docket files of its accident investigations, or its computerized accident database(s) shall be...

49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

Code of Federal Regulations, 2013 CFR

2013-10-01

... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's official public docket files of its accident investigations, or its computerized accident database(s) shall be...

49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

Code of Federal Regulations, 2011 CFR

2011-10-01

... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's official public docket files of its accident investigations, or its computerized accident database(s) shall be...

Results of an academic promotion and career path survey of faculty at the Johns Hopkins University School of Medicine.

PubMed

Thomas, Patricia A; Diener-West, Marie; Canto, Marcia I; Martin, Don R; Post, Wendy S; Streiff, Michael B

2004-03-01

Clinician-educator faculty are increasing in numbers in academic medical centers, but their academic advancement is slower than that of research faculty. The authors sought to quantify the magnitude of this difference in career advancement and to explore the characteristics of faculty that might explain the difference. In 1999, a questionnaire was administered to all MD faculty at the rank of instructor and above (259) in the Department of Medicine at the Johns Hopkins University School of Medicine. A total of 180 (69%) faculty returned questionnaires. Of these, 178 identified with one of four career paths: basic researcher (46), clinical researcher (69), academic clinician (38), or teacher-clinician (25). Career path did not differ by age, gender, rank, years on faculty, hours worked per week, family responsibility, or global work satisfaction. After adjusting for age, gender, time at rank, and work satisfaction, the odds of being at a higher rank were 85% less for academic clinicians (odds ratio,.15; 95% confidence interval, 0.06-0.40) and 69% less for teacher-clinicians (odds ratio,.31; 95% confidence interval, 0.11-0.88) than for basic researchers. Clinical researchers did not differ from basic researchers in the likelihood of being at higher rank. Similarly, compared with basic research faculty, the adjusted odds of being more satisfied with progress towards academic promotion were 92% lower for academic clinicians and 87% lower for teacher-clinicians. Clinician-educator faculty were less likely to be at higher rank at this institution than were faculty in research paths. Differences in rank may be explained by lower rank at hire for faculty in these career paths, time available for scholarly activities, or other resources available to support scholarship. Retaining clinician-educators will require further exploration of barriers to promotion inherent to these career paths and methods of modifying these barriers.

[Occupational accidents in an oil refinery in Brazil].

PubMed

Souza, Carlos Augusto Vaz de; Freitas, Carlos Machado de

2002-10-01

Work in oil refineries involves the risk of minor to major accidents. National data show the impact of accidents on this industry. A study was carried out to describe accident profile and evaluate the adequacy of accident reporting system. Data on all accidents reported in an oil refinery in the state of Rio de Janeiro for the year 1997 were organized and analyzed. The study population consisted of 153 injury cases, 83 hired and 69 contracted workers. The variables were: type of accident, operation mode and position of the worker injured. Among hired workers, minor accidents predominated (54.2%) and they occurred during regular operation activities (62.9%). Among contracted workers, there also predominated minor accidents (75.5%) in a higher percentage, but they occurred mainly during maintenance activities (96.8%). The study results showed that there is a predominance of accidents in lower hierarchy workers, and these accidents occur mainly during maintenance activities. There is a need to improve the company's accident reporting system and accident investigation procedures.

Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain.

PubMed

Gatchel, Robert J; Bevers, Kelley; Licciardone, John C; Su, Jianzhong; Du, Ying; Brotto, Marco

2018-05-17

Traditionally, there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory, where an injury leads to acute episodes, subacute stages, and progresses to a chronic pain condition. However, it appears that pain progression is much more complicated and individualized than this original unsupported assumption. It is now becoming apparent that, while this linear progression may occur, it is not the only path that pain, specifically low-back pain, follows. It is clear there is a definite need to evaluate how low-back pain trajectories are classified and, subsequently, how we can more effectively intervene during these progression stages. In order to better understand and manage pain conditions, we must examine the different pain trajectories, and develop a standard by which to use these classifications, so that clinicians can better identify and predict patient-needs and customize treatments for maximum efficacy. The present article examines the most recent trajectory research, and highlights the importance of developing a broader model for patient evaluation.

Recent Progresses of Microwave Marine Remote Sensing

NASA Astrophysics Data System (ADS)

Yang, Jingsong; Ren, Lin; Zheng, Gang; Wang, He; He, Shuangyan; Wang, Juan; Li, Xiaohui

2016-08-01

It is presented in this paper the recent progresses of Dragon 3 Program (ID. 10412) in the field of microwave marine remote sensing including (1) ocean surface wind fields from full polarization synthetic aperture radars (SAR), (2) joint retrieval of directional ocean wave spectra from SAR and wave spectrometer, (3) error analysis on ENVISAT ASAR wave mode significant wave height (SWH) retrievals using triple collocation model, (4) typhoon observation from SAR and optical sensors, (5) ocean internal wave observation from SAR and optical sensors, (6) ocean eddy observation from SAR and optical sensors, (7) retrieval models of water vapor and wet tropospheric path delay for the HY-2A calibration microwave radiometer, (8) calibration of SWH from HY-2A satellite altimeter.

Beller Lecture: Is Understanding the Past in Its Own Terms Understanding?

NASA Astrophysics Data System (ADS)

Wootton, David

History of Science is in a state of intellectual confusion symbolized by its hostility to what is called ``Whig history''. The fundamental issue is whether it is legitimate to use hindsight in the writing of history. In this lecture I will defend retrospective history in three key respects: a) retrospection is generally a legitimate procedure in historical writing, primarily because historical outcomes are often unintended and unpredictable; b) retrospection is particularly legitimate where science is concerned because scientific development is path dependent; c) restrospection is particularly legitimate in history of science because science progresses, and progress can only be identified retrospectively. Defending retrospection is entirely compatible with recognizing that science is culturally specific; thus retrospection need not involve anachronism. See www.inventionofscience.com

Study of gamma ray energy absorption and exposure buildup factors for ferrites by geometric progression fitting method

NASA Astrophysics Data System (ADS)

Raut, S. D.; Awasarmol, V. V.; Shaikh, S. F.; Ghule, B. G.; Ekar, S. U.; Mane, R. S.; Pawar, P. P.

2018-04-01

The gamma ray energy absorption and exposure buildup factors (EABF and EBF) were calculated for ferrites such as cobalt ferrite (CoFe2O4), zinc ferrite (ZnFe2O4), nickel ferrite (NiFe2O4) and magnesium ferrite (MgFe2O4) using five parametric geometric progression (G-P fitting) formula in the energy range 0.015-15.00 MeV up to the penetration depth 40 mean free path (mfp). The obtained data of absorption and exposure buildup factors have been studied as a function of incident photon energy and penetration depth. The obtained EABF and EBF data are useful for radiation dosimetry and radiation therapy.

Chornobyl Nuclear Power Plant - An Overview of the Current Efforts to Stabilize the Chornobyl Shelter and Establish an Environmentally Safe Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Couch, Daniel P.; Gronier, Serge; Heriot, Ian D.

2005-08-08

Chornobyl Nuclear Power Plant ? An Overview of the Current Efforts to Stabilize the Chornobyl Shelter and Establish an Environmentally Safe Site Abstract?The 1986 accident at the Chornobyl Nuclear Power Plant in Ukraine resulted in the destruction of the reactor core and most of the reactor building. The Chornobyl accident released an enormous quantity of radionuclides into the environment, significantly contaminating a large region around the plant. Within seven months of the accident, the damaged Unit 4 was encased in a massive concrete and steel enclosure known as the Shelter. Deterioration of the Shelter over time poses increasing risks. Themore » Shelter is subject to structural damage or collapse due to wind, snow loading, or seismic activity. Collapse could lead to the release of radioactive fallout. Leakage of rainwater into the Shelter has caused the accumulation of a large quantity of highly radioactive liquid, corrosion of extremely contaminated nuclear fuel debris, and creation of hazardous radioactive dust. To address these concerns, the government of Ukraine, the G7 nations, and additional donor countries adopted the Shelter Implementation Plan (SIP) in 1997. The SIP's objectives are to reduce the risk and potential consequences of accidental collapse of the Shelter; improve nuclear, industrial and environmental safety; and develop a long-term strategy for conversion to an environmentally safe site. Implementation of the SIP has made significant progress that will lead to the construction of a new confinement facility by 2009. (Full paper available by contacting lead author, Dan Couch)« less

Developing an eHealth Tool to Support Patient Empowerment at Home.

PubMed

Schildmeijer, Kristina; Wannheden, Carolina; Nilsson, Lina; Frykholm, Oscar; Hellström, Amanda; Flink, Maria; Ekstedt, Mirjam

2018-01-01

In previous research we have learned that patients with chronic or complex diseases often experience difficulties when transitioning from hospital care to self-care in their home. We address these difficulties by developing an eHealth tool for patients - ePATH (electronic Patient Activation in Treatment at Home) - intended to empower each patient to manage their individual situation. We have employed a user-centered design process involving both patients and healthcare personnel to specify the content and functionality of ePATH. The system is deployed as a web application with secure login for patients. In this article, we describe the main content and functionality of the system that makes it possible for a patient to manage symptoms development in relation to treatment progression Interactive functionality, e.g., reminders and social support, is included to make the ePATH a useful and informative bridge between patients, next-of-kin and different caregivers. One lesson learned is that it is necessary to incorporate motivational components in the development of an eHealth tool to successfully overcome the "intention-behavior" gap. The self-determination theory of motivation can be used to ensure that important aspects are not missed.

Data Science in Radiology: A Path Forward.

PubMed

Aerts, Hugo J W L

2018-02-01

Artificial intelligence (AI), especially deep learning, has the potential to fundamentally alter clinical radiology. AI algorithms, which excel in quantifying complex patterns in data, have shown remarkable progress in applications ranging from self-driving cars to speech recognition. The AI application within radiology, known as radiomics, can provide detailed quantifications of the radiographic characteristics of underlying tissues. This information can be used throughout the clinical care path to improve diagnosis and treatment planning, as well as assess treatment response. This tremendous potential for clinical translation has led to a vast increase in the number of research studies being conducted in the field, a number that is expected to rise sharply in the future. Many studies have reported robust and meaningful findings; however, a growing number also suffer from flawed experimental or analytic designs. Such errors could not only result in invalid discoveries, but also may lead others to perpetuate similar flaws in their own work. This perspective article aims to increase awareness of the issue, identify potential reasons why this is happening, and provide a path forward. Clin Cancer Res; 24(3); 532-4. ©2017 AACR . ©2017 American Association for Cancer Research.

Long Open Path Fourier Transform Spectroscopy Measurements of Greenhouse Gases in the Near Infrared

NASA Astrophysics Data System (ADS)

Griffith, D. W. T.

2015-12-01

Atmospheric composition measurements are an important tool to quantify local and regional emissions and sinks of greenhouse gases. Most in situ measurements are made at a point, but how representative are such measurements in an inhomogeneous environment? Open path Fourier Transform Spectroscopy (FTS) measurements potentially offer spatial averaging and continuous measurements of several trace gases (including CO2, CH4, CO and N2O) simultaneously in the same airmass. Spatial averaging over kilometre scales is a better fit to the finest scale atmospheric models becoming available, and helps bridge the gap between models and in situ measurements. In this paper we assess the precision, accuracy and reliability of long open path measurements by Fourier Transform Spectroscopy in the near infrared from a 5-month continuous record of measurements over a 1.5 km pathlength. Direct open-atmosphere measurements of trace gases CO2, CH4, CO and N2O as well as O2 were retrieved from several absorption bands between 4000 and 8000 cm-1 (2.5 - 1.25 micron). At one end of the path an in situ FTIR analyser simultaneously collected well calibrated measurements of the same species for comparison with the open path-integrated measurements. The measurements ran continuously from June - November 2014. We introduce the open path FTS measurement system and present an analysis of the results, including assessment of precision, accuracy relative to co-incident in situ measurements, reliability. Short term precision of the open path measurement of CO2 was better than 1 ppm for 5 minute averages and thus sufficient for studies in urban and other non-background environments. Measurement bias relative to calibrated in situ measurements was stable across the measurement period. The system operated reliably with data losses mainly due to weather events such as rain and fog preventing transmission of the IR beam. In principle the system can be improved to provide longer pathlengths and higher precision, and we present recent progress in improving the original measurements.

Progress In Developing An In-Pile Acoustically Telemetered Sensor Infrastructure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, James A.; Garrett, Steven L.; Heibel, Michael D.

2016-09-01

A salient grand challenge for a number of Department of Energy programs such as Fuels Cycle Research and Development ( includes Accident Tolerant Fuel research and the Transient Reactor Test Facility Restart experiments), Light Water Sustainability, and Advanced Reactor Technologies is to enhance our fundamental understanding of fuel and materials behavior under irradiation. Robust and accurate in-pile measurements will be instrumental to develop and validate a computationally predictive multi-scale understanding of nuclear fuel and materials. This sensing technology will enable the linking of fundamental micro-structural evolution mechanisms to the macroscopic degradation of fuels and materials. The in situ sensors andmore » measurement systems will monitor local environmental parameters as well as characterize microstructure evolution during irradiation. One of the major road blocks in developing practical robust, and cost effective in-pile sensor systems, are instrument leads. If a wireless telemetry infrastructure can be developed for in-pile use, in-core measurements would become more attractive and effective. Thus to be successful in accomplishing effective in-pile sensing and microstructure characterization an interdisciplinary measurement infrastructure needs to be developed in parallel with key sensing technology. For the discussion in this research, infrastructure is defined as systems, technology, techniques, and algorithms that may be necessary in the delivery of beneficial and robust data from in-pile devices. The architecture of a system’s infrastructure determines how well it operates and how flexible it is to meet future requirements. The limiting path for the effective deployment of the salient sensing technology will not be the sensors themselves but the infrastructure that is necessary to communicate data from in-pile to the outside world in a non-intrusive and reliable manner. This article gives a high level overview of a promising telemetry infrastructure based on acoustic wireless transmission of data that is being developed and tested by the INL, Penn State and Westinghouse.« less

Revolution of Alzheimer Precision Neurology Passageway of Systems Biology and Neurophysiology.

PubMed

Hampel, Harald; Toschi, Nicola; Babiloni, Claudio; Baldacci, Filippo; Black, Keith L; Bokde, Arun L W; Bun, René S; Cacciola, Francesco; Cavedo, Enrica; Chiesa, Patrizia A; Colliot, Olivier; Coman, Cristina-Maria; Dubois, Bruno; Duggento, Andrea; Durrleman, Stanley; Ferretti, Maria-Teresa; George, Nathalie; Genthon, Remy; Habert, Marie-Odile; Herholz, Karl; Koronyo, Yosef; Koronyo-Hamaoui, Maya; Lamari, Foudil; Langevin, Todd; Lehéricy, Stéphane; Lorenceau, Jean; Neri, Christian; Nisticò, Robert; Nyasse-Messene, Francis; Ritchie, Craig; Rossi, Simone; Santarnecchi, Emiliano; Sporns, Olaf; Verdooner, Steven R; Vergallo, Andrea; Villain, Nicolas; Younesi, Erfan; Garaci, Francesco; Lista, Simone

2018-03-16

The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an "omics"-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical, and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer's disease. The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group "Alzheimer Precision Medicine" (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development toward breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND.

Revolution of Alzheimer Precision Neurology: Passageway of Systems Biology and Neurophysiology

PubMed Central

Hampel, Harald; Toschi, Nicola; Babiloni, Claudio; Baldacci, Filippo; Black, Keith L.; Bokde, Arun L.W.; Bun, René S.; Cacciola, Francesco; Cavedo, Enrica; Chiesa, Patrizia A.; Colliot, Olivier; Coman, Cristina-Maria; Dubois, Bruno; Duggento, Andrea; Durrleman, Stanley; Ferretti, Maria-Teresa; George, Nathalie; Genthon, Remy; Habert, Marie-Odile; Herholz, Karl; Koronyo, Yosef; Koronyo-Hamaoui, Maya; Lamari, Foudil; Langevin, Todd; Lehéricy, Stéphane; Lorenceau, Jean; Neri, Christian; Nisticò, Robert; Nyasse-Messene, Francis; Ritchie, Craig; Rossi, Simone; Santarnecchi, Emiliano; Sporns, Olaf; Verdooner, Steven R.; Vergallo, Andrea; Villain, Nicolas; Younesi, Erfan; Garaci, Francesco; Lista, Simone

2018-01-01

The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer’s disease (AD). The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group “Alzheimer Precision Medicine” (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development towards breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND. PMID:29562524

Analysis of National Major Work Safety Accidents in China, 2003–2012

PubMed Central

YE, Yunfeng; ZHANG, Siheng; RAO, Jiaming; WANG, Haiqing; LI, Yang; WANG, Shengyong; DONG, Xiaomei

2016-01-01

Background: This study provides a national profile of major work safety accidents in China, which cause more than 10 fatalities per accident, intended to provide scientific basis for prevention measures and strategies to reduce major work safety accidents and deaths. Methods: Data from 2003–2012 Census of major work safety accidents were collected from State Administration of Work Safety System (SAWS). Published literature and statistical yearbook were also included to implement information. We analyzed the frequency of accidents and deaths, trend, geographic distribution and injury types. Additionally, we discussed the severity and urgency of emergency rescue by types of accidents. Results: A total of 877 major work safety accidents were reported, resulting in 16,795 deaths and 9,183 injuries. The numbers of accidents and deaths, mortality rate and incidence of major accidents have declined in recent years. The mortality rate and incidence was 0.71 and 1.20 per 106 populations in 2012, respectively. Transportation and mining contributed to the highest number of major accidents and deaths. Major aviation and railway accidents caused more casualties per incident, while collapse, machinery, electrical shock accidents and tailing dam accidents were the most severe situation that resulted in bigger proportion of death. Conclusion: Ten years’ major work safety accident data indicate that the frequency of accidents and number of eaths was declined and several safety concerns persist in some segments. PMID:27057515

Accident history, risk perception and traffic safe behaviour.

PubMed

Ngueutsa, Robert; Kouabenan, Dongo Rémi

2017-09-01

This study clarifies the associations between accident history, perception of the riskiness of road travel and traffic safety behaviours by taking into account the number and severity of accidents experienced. A sample of 525 road users in Cameroon answered a questionnaire comprising items on perception of risk, safe behaviour and personal accident history. Participants who reported involvement in more than three accidents or involvement in a severe accident perceived road travel as less risky and also reported behaving less safely compared with those involved in fewer, or less severe accidents. The results have practical implications for the prevention of traffic accidents. Practitioner Summary: The associations between accident history, perceived risk of road travel and safe behaviour were investigated using self-report questionnaire data. Participants involved in more than three accidents, or in severe accidents, perceived road travel as less risky and also reported more unsafe behaviour compared with those involved in fewer, or less severe accidents. Campaigns targeting people with a less serious, less extensive accident history should aim to increase awareness of hazards and the potential severity of their consequences, as well as emphasising how easy it is to take the recommended preventive actions. Campaigns targeting those involved in more frequent accidents, and survivors of serious accidents, should address feelings of invulnerability and helplessness.

Estimation of fatality and injury risk by means of in-depth fatal accident investigation data.

PubMed

Yannis, George; Papadimitriou, Eleonora; Dupont, Emmanuelle; Martensen, Heike

2010-10-01

In this article the factors affecting fatality and injury risk of road users involved in fatal accidents are analyzed by means of in-depth accident investigation data, with emphasis on parameters not extensively explored in previous research. A fatal accident investigation (FAI) database is used, which includes intermediate-level in-depth data for a harmonized representative sample of 1300 fatal accidents in 7 European countries. The FAI database offers improved potential for analysis, because it includes information on a number of variables that are seldom available, complete, or accurately recorded in road accident databases. However, the fact that only fatal accidents are examined requires for methodological adjustments, namely, the correction for two types of effects on a road user's baseline risk: "accident size" effects, and "relative vulnerability" effects. Fatality and injury risk can be then modeled through multilevel logistic regression models, which account for the hierarchical dependences of the road accident process. The results show that the baseline fatality risk of road users involved in fatal accidents decreases with accident size and increases with the vulnerability of the road user. On the contrary, accident size increases nonfatal injury risk of road users involved in fatal accidents. Other significant effects on fatality and injury risk in fatal accidents include road user age, vehicle type, speed limit, the chain of accident events, vehicle maneuver, and safety equipment. In particular, the presence and use of safety equipment such as seat belt, antilock braking system (ABS), and electronic stability program (ESP) are protection factors for car occupants, especially for those seated at the front seats. Although ABS and ESP systems are typically associated with positive effects on accident occurrence, the results of this research revealed significant related effects on accident severity as well. Moreover, accident consequences are more severe when the most harmful event of the accident occurs later within the accident chain.

Developing techniques for cause-responsibility analysis of occupational accidents.

PubMed

Jabbari, Mousa; Ghorbani, Roghayeh

2016-11-01

The aim of this study was to specify the causes of occupational accidents, determine social responsibility and the role of groups involved in work-related accidents. This study develops occupational accidents causes tree, occupational accidents responsibility tree, and occupational accidents component-responsibility analysis worksheet; based on these methods, it develops cause-responsibility analysis (CRA) techniques, and for testing them, analyzes 100 fatal/disabling occupational accidents in the construction setting that were randomly selected from all the work-related accidents in Tehran, Iran, over a 5-year period (2010-2014). The main result of this study involves two techniques for CRA: occupational accidents tree analysis (OATA) and occupational accidents components analysis (OACA), used in parallel for determination of responsible groups and responsibilities rate. From the results, we find that the management group of construction projects has 74.65% responsibility of work-related accidents. The developed techniques are purposeful for occupational accidents investigation/analysis, especially for the determination of detailed list of tasks, responsibilities, and their rates. Therefore, it is useful for preventing work-related accidents by focusing on the responsible group's duties. Copyright © 2016 Elsevier Ltd. All rights reserved.

Workplace accidents in materials transfer in Finland.

PubMed

Perttula, Pia; Salminen, Simo

2012-01-01

The aim of this study was to show the proportion of workplace accidents related to materials transfer and to decide whether they were more serious than other kinds of workplace accidents. The research material for this study were statistics and data, available in Finland, regarding workplace accidents and fatal accidents. Twenty-five percent of studied fatal accidents were related to materials transfer; 26.9-27.7% of all workplace accidents in Finland in 2003-2007 were workplace accidents related to materials transfer. Over half (54.7%) of workplace accidents related to materials transfer caused disabilities lasting over 3 days. Most accidents related to materials transfer occurred to men aged 20-49 years. The most common types of injuries were dislocations, sprains and strains.

Space Shuttle Columbia and Fukushima Nuclear Plant, Similarities and Differences in Organizational Accidents and Lessons Learned

NASA Astrophysics Data System (ADS)

Mitsui, Masami; Takeuchi, Nobuo; Kawada, Yasuhiro; Kobayashi, Royoji; Nogami, Manami; Miki, Masami

2013-09-01

When records of success are accumulating, we should be most alert to maintain the safety culture we labored to establish and nurture.Space Shuttle Columbia Accident in 2002 and Fukushima Nuclear Power Station Accident in 2011 are seemingly unrelated. But, by studying the accident reports issued after these accidents, the authors found that the organizational causes that led to the accidents were surprisingly similar. The causes of these accidents were rooted in the history and culture of the respective organizations.In this paper, the authors will discuss differences and similarities in these two accidents based on the reports submitted by the accident investigation boards of these two accidents. This will be followed by the lessons learned the authors derived.

Sleepy driver near-misses may predict accident risks.

PubMed

Powell, Nelson B; Schechtman, Kenneth B; Riley, Robert W; Guilleminault, Christian; Chiang, Rayleigh Ping-ying; Weaver, Edward M

2007-03-01

To quantify the prevalence of self-reported near-miss sleepy driving accidents and their association with self-reported actual driving accidents. A prospective cross-sectional internet-linked survey on driving behaviors. Dateline NBC News website. Results are given on 35,217 (88% of sample) individuals with a mean age of 37.2 +/- 13 years, 54.8% women, and 87% white. The risk of at least one accident increased monotonically from 23.2% if there were no near-miss sleepy accidents to 44.5% if there were > or = 4 near-miss sleepy accidents (P < 0.0001). After covariate adjustments, subjects who reported at least one near-miss sleepy accident were 1.13 (95% CI, 1.10 to 1.16) times as likely to have reported at least one actual accident as subjects reporting no near-miss sleepy accidents (P < 0.0001). The odds of reporting at least one actual accident in those reporting > or = 4 near-miss sleepy accidents as compared to those reporting no near-miss sleepy accidents was 1.87 (95% CI, 1.64 to 2.14). Furthermore, after adjustments, the summary Epworth Sleepiness Scale (ESS) score had an independent association with having a near-miss or actual accident. An increase of 1 unit of ESS was associated with a covariate adjusted 4.4% increase of having at least one accident (P < 0.0001). A statistically significant dose-response was seen between the numbers of self-reported sleepy near-miss accidents and an actual accident. These findings suggest that sleepy near-misses may be dangerous precursors to an actual accident.

Modeling secondary accidents identified by traffic shock waves.

PubMed

Junhua, Wang; Boya, Liu; Lanfang, Zhang; Ragland, David R

2016-02-01

The high potential for occurrence and the negative consequences of secondary accidents make them an issue of great concern affecting freeway safety. Using accident records from a three-year period together with California interstate freeway loop data, a dynamic method for more accurate classification based on the traffic shock wave detecting method was used to identify secondary accidents. Spatio-temporal gaps between the primary and secondary accident were proven be fit via a mixture of Weibull and normal distribution. A logistic regression model was developed to investigate major factors contributing to secondary accident occurrence. Traffic shock wave speed and volume at the occurrence of a primary accident were explicitly considered in the model, as a secondary accident is defined as an accident that occurs within the spatio-temporal impact scope of the primary accident. Results show that the shock waves originating in the wake of a primary accident have a more significant impact on the likelihood of a secondary accident occurrence than the effects of traffic volume. Primary accidents with long durations can significantly increase the possibility of secondary accidents. Unsafe speed and weather are other factors contributing to secondary crash occurrence. It is strongly suggested that when police or rescue personnel arrive at the scene of an accident, they should not suddenly block, decrease, or unblock the traffic flow, but instead endeavor to control traffic in a smooth and controlled manner. Also it is important to reduce accident processing time to reduce the risk of secondary accident. Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparisons of Traffic Collisions between Expressways and Rural Roads in Truck Drivers.

PubMed

Lee, Sangbok; Jeong, Byung Yong

2016-03-01

Truck driving is known as one of the occupations with the highest accident rate. This study investigates the characteristics of traffic collisions according to road types (expressway and rural road). Classifying 267 accidents into expressway and rural road, we analyzed them based on driver characteristics (age, working experience, size of employment), time characteristics (day of accident, time, weather), and accident characteristics (accident causes, accident locations, accident types, driving conditions). When we compared the accidents by road conditions, no differences were found between the driver characteristics. However, from the accident characteristics, the injured person distributions were different by the road conditions. In particular, driving while drowsy is shown to be highly related with the accident characteristics. This study can be used as a guideline and a base line to develop a plan of action to prevent traffic accidents. It can also help to prepare formal regulations about a truck driver's vehicle maintenance and driving attitude for a precaution on road accidents.

Accidents in Germany: evaluation of the german telephone health survey 2004.

PubMed

Saß, Anke-Christine

2008-09-01

In the year 2006 there were over 19 000 fatal accidents in Germany and estimates put the number of accidental injuries at more than 8 million. Detailed information on the pattern of accidents is indispensable for the definition of priorities in accident prevention. The German Telephone Health Survey 2004 provides representative cross-sectional data on the health of German residents from 18 years of age (n = 7341). Questions on the prevalence of accidents (13 items) were selected for analysis. Every tenth interviewee reported being injured in an accident in the previous 12 months. Men, particularly young men, are at greater risk of accidents than women. Almost one third of all accidents occurred at home. Social status had no influence on the probability of having an accident, but did affect where the accident happened. The survey yields information on the overall pattern of non-fatal accidents in Germany. The data point to target groups for accident prevention measures.

Occurrence and countermeasures of urban power grid accident

NASA Astrophysics Data System (ADS)

Wei, Wang; Tao, Zhang

2018-03-01

With the advance of technology, the development of network communication and the extensive use of power grids, people can get to know power grid accidents around the world through the network timely. Power grid accidents occur frequently. Large-scale power system blackout and casualty accidents caused by electric shock are also fairly commonplace. All of those accidents have seriously endangered the property and personal safety of the country and people, and the development of society and economy is severely affected by power grid accidents. Through the researches on several typical cases of power grid accidents at home and abroad in recent years and taking these accident cases as the research object, this paper will analyze the three major factors that cause power grid accidents at present. At the same time, combining with various factors and impacts caused by power grid accidents, the paper will put forward corresponding solutions and suggestions to prevent the occurrence of the accident and lower the impact of the accident.

Comparisons of Traffic Collisions between Expressways and Rural Roads in Truck Drivers

PubMed Central

Lee, Sangbok; Jeong, Byung Yong

2015-01-01

Background Truck driving is known as one of the occupations with the highest accident rate. This study investigates the characteristics of traffic collisions according to road types (expressway and rural road). Methods Classifying 267 accidents into expressway and rural road, we analyzed them based on driver characteristics (age, working experience, size of employment), time characteristics (day of accident, time, weather), and accident characteristics (accident causes, accident locations, accident types, driving conditions). Results When we compared the accidents by road conditions, no differences were found between the driver characteristics. However, from the accident characteristics, the injured person distributions were different by the road conditions. In particular, driving while drowsy is shown to be highly related with the accident characteristics. Conclusion This study can be used as a guideline and a base line to develop a plan of action to prevent traffic accidents. It can also help to prepare formal regulations about a truck driver's vehicle maintenance and driving attitude for a precaution on road accidents. PMID:27014489

Open-path FTIR data reduction algorithm with atmospheric absorption corrections: the NONLIN code

NASA Astrophysics Data System (ADS)

Phillips, William; Russwurm, George M.

1999-02-01

This paper describes the progress made to date in developing, testing, and refining a data reduction computer code, NONLIN, that alleviates many of the difficulties experienced in the analysis of open path FTIR data. Among the problems that currently effect FTIR open path data quality are: the inability to obtain a true I degree or background, spectral interferences of atmospheric gases such as water vapor and carbon dioxide, and matching the spectral resolution and shift of the reference spectra to a particular field instrument. This algorithm is based on a non-linear fitting scheme and is therefore not constrained by many of the assumptions required for the application of linear methods such as classical least squares (CLS). As a result, a more realistic mathematical model of the spectral absorption measurement process can be employed in the curve fitting process. Applications of the algorithm have proven successful in circumventing open path data reduction problems. However, recent studies, by one of the authors, of the temperature and pressure effects on atmospheric absorption indicate there exist temperature and water partial pressure effects that should be incorporated into the NONLIN algorithm for accurate quantification of gas concentrations. This paper investigates the sources of these phenomena. As a result of this study a partial pressure correction has been employed in NONLIN computer code. Two typical field spectra are examined to determine what effect the partial pressure correction has on gas quantification.

Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways.

PubMed

Pey, Jon; Valgepea, Kaspar; Rubio, Angel; Beasley, John E; Planes, Francisco J

2013-12-08

The study of cellular metabolism in the context of high-throughput -omics data has allowed us to decipher novel mechanisms of importance in biotechnology and health. To continue with this progress, it is essential to efficiently integrate experimental data into metabolic modeling. We present here an in-silico framework to infer relevant metabolic pathways for a particular phenotype under study based on its gene/protein expression data. This framework is based on the Carbon Flux Path (CFP) approach, a mixed-integer linear program that expands classical path finding techniques by considering additional biophysical constraints. In particular, the objective function of the CFP approach is amended to account for gene/protein expression data and influence obtained paths. This approach is termed integrative Carbon Flux Path (iCFP). We show that gene/protein expression data also influences the stoichiometric balancing of CFPs, which provides a more accurate picture of active metabolic pathways. This is illustrated in both a theoretical and real scenario. Finally, we apply this approach to find novel pathways relevant in the regulation of acetate overflow metabolism in Escherichia coli. As a result, several targets which could be relevant for better understanding of the phenomenon leading to impaired acetate overflow are proposed. A novel mathematical framework that determines functional pathways based on gene/protein expression data is presented and validated. We show that our approach is able to provide new insights into complex biological scenarios such as acetate overflow in Escherichia coli.

A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin

PubMed Central

Doctrow, Susan R.; Lopez, Argelia; Schock, Ashley M.; Duncan, Nathan E.; Jourdan, Megan M.; Olasz, Edit B.; Moulder, John E.; Fish, Brian L.; Mäder, Marylou; Lazar, Jozef; Lazarova, Zelmira

2012-01-01

In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 h after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 h after exposure. PMID:23190879

A Progressive Damage Methodology for Residual Strength Predictions of Center-Crack Tension Composite Panels

NASA Technical Reports Server (NTRS)

Coats, Timothy William

1996-01-01

An investigation of translaminate fracture and a progressive damage methodology was conducted to evaluate and develop a residual strength prediction capability for laminated composites with through penetration notches. This is relevant to the damage tolerance of an aircraft fuselage that might suffer an in-flight accident such as an uncontained engine failure. An experimental characterization of several composite materials systems revealed an R-curve type of behavior. Fractographic examinations led to the postulate that this crack growth resistance could be due to fiber bridging, defined here as fractured fibers of one ply bridged by intact fibers of an adjacent ply. The progressive damage methodology is currently capable of predicting the initiation and growth of matrix cracks and fiber fracture. Using two difference fiber failure criteria, residual strength was predicted for different size panel widths and notch lengths. A ply discount fiber failure criterion yielded extremely conservative results while an elastic-perfectly plastic fiber failure criterion showed that the fiber bridging concept is valid for predicting residual strength for tensile dominated failure loads. Furthermore, the R-curves predicted by the model using the elastic-perfectly plastic fiber criterion compared very well with the experimental R-curves.

Path integral molecular dynamics for exact quantum statistics of multi-electronic-state systems.

PubMed

Liu, Xinzijian; Liu, Jian

2018-03-14

An exact approach to compute physical properties for general multi-electronic-state (MES) systems in thermal equilibrium is presented. The approach is extended from our recent progress on path integral molecular dynamics (PIMD), Liu et al. [J. Chem. Phys. 145, 024103 (2016)] and Zhang et al. [J. Chem. Phys. 147, 034109 (2017)], for quantum statistical mechanics when a single potential energy surface is involved. We first define an effective potential function that is numerically favorable for MES-PIMD and then derive corresponding estimators in MES-PIMD for evaluating various physical properties. Its application to several representative one-dimensional and multi-dimensional models demonstrates that MES-PIMD in principle offers a practical tool in either of the diabatic and adiabatic representations for studying exact quantum statistics of complex/large MES systems when the Born-Oppenheimer approximation, Condon approximation, and harmonic bath approximation are broken.

Path integral molecular dynamics for exact quantum statistics of multi-electronic-state systems

NASA Astrophysics Data System (ADS)

Liu, Xinzijian; Liu, Jian

2018-03-01

An exact approach to compute physical properties for general multi-electronic-state (MES) systems in thermal equilibrium is presented. The approach is extended from our recent progress on path integral molecular dynamics (PIMD), Liu et al. [J. Chem. Phys. 145, 024103 (2016)] and Zhang et al. [J. Chem. Phys. 147, 034109 (2017)], for quantum statistical mechanics when a single potential energy surface is involved. We first define an effective potential function that is numerically favorable for MES-PIMD and then derive corresponding estimators in MES-PIMD for evaluating various physical properties. Its application to several representative one-dimensional and multi-dimensional models demonstrates that MES-PIMD in principle offers a practical tool in either of the diabatic and adiabatic representations for studying exact quantum statistics of complex/large MES systems when the Born-Oppenheimer approximation, Condon approximation, and harmonic bath approximation are broken.

Auto-rickshaw: an automated crystal structure determination platform as an efficient tool for the validation of an X-ray diffraction experiment.

PubMed

Panjikar, Santosh; Parthasarathy, Venkataraman; Lamzin, Victor S; Weiss, Manfred S; Tucker, Paul A

2005-04-01

The EMBL-Hamburg Automated Crystal Structure Determination Platform is a system that combines a number of existing macromolecular crystallographic computer programs and several decision-makers into a software pipeline for automated and efficient crystal structure determination. The pipeline can be invoked as soon as X-ray data from derivatized protein crystals have been collected and processed. It is controlled by a web-based graphical user interface for data and parameter input, and for monitoring the progress of structure determination. A large number of possible structure-solution paths are encoded in the system and the optimal path is selected by the decision-makers as the structure solution evolves. The processes have been optimized for speed so that the pipeline can be used effectively for validating the X-ray experiment at a synchrotron beamline.

HARPA: A versatile three-dimensional Hamiltonian ray-tracing program for acoustic waves in the atmosphere above irregular terrain

NASA Astrophysics Data System (ADS)

Jones, R. M.; Riley, J. P.; Georges, T. M.

1986-08-01

The modular FORTRAN 77 computer program traces the three-dimensional paths of acoustic rays through continuous model atmospheres by numerically integrating Hamilton's equations (a differential expression of Fermat's principle). The user specifies an atmospheric model by writing closed-form formulas for its three-dimensional wind and temperature (or sound speed) distribution, and by defining the height of the reflecting terrain vs. geographic latitude and longitude. Some general-purpose models are provided, or users can readily design their own. In addition to computing the geometry of each raypath, HARPA can calculate pulse travel time, phase time, Doppler shift (if the medium varies in time), absorption, and geometrical path length. The program prints a step-by-step account of a ray's progress. The 410-page documentation describes the ray-tracing equations and the structure of the program, and provides complete instructions, illustrated by a sample case.

Planning for execution monitoring on a planetary rover

NASA Technical Reports Server (NTRS)

Gat, Erann; Firby, R. James; Miller, David P.

1990-01-01

A planetary rover will be traversing largely unknown and often unknowable terrain. In addition to geometric obstacles such as cliffs, rocks, and holes, it may also have to deal with non-geometric hazards such as soft soil and surface breakthroughs which often cannot be detected until rover is in imminent danger. Therefore, the rover must monitor its progress throughout a traverse, making sure to stay on course and to detect and act on any previously unseen hazards. Its onboard planning system must decide what sensors to monitor, what landmarks to take position readings from, and what actions to take if something should go wrong. The planning systems being developed for the Pathfinder Planetary Rover to perform these execution monitoring tasks are discussed. This system includes a network of planners to perform path planning, expectation generation, path analysis, sensor and reaction selection, and resource allocation.

Imaging open-path Fourier transform infrared spectrometer for 3D cloud profiling

NASA Astrophysics Data System (ADS)

Rentz Dupuis, Julia; Mansur, David J.; Engel, James R.; Vaillancourt, Robert; Todd, Lori; Mottus, Kathleen

2008-04-01

OPTRA and University of North Carolina are developing an imaging open-path Fourier transform infrared (I-OP-FTIR) spectrometer for 3D profiling of chemical and biological agent simulant plumes released into test ranges and chambers. An array of I-OP-FTIR instruments positioned around the perimeter of the test site, in concert with advanced spectroscopic algorithms, enables real time tomographic reconstruction of the plume. The approach will be considered as a candidate referee measurement for test ranges and chambers. This Small Business Technology Transfer (STTR) effort combines the instrumentation and spectroscopic capabilities of OPTRA, Inc. with the computed tomographic expertise of the University of North Carolina, Chapel Hill. In this paper, we summarize progress to date and overall system performance projections based on the instrument, spectroscopy, and tomographic reconstruction accuracy. We then present a preliminary optical design of the I-OP-FTIR.

NASA/FAA Tailplane Icing Program: Flight Test Report

NASA Technical Reports Server (NTRS)

Ratvasky, Thomas P.; VanZante, Judith Foss; Sim, Alex

2000-01-01

This report presents results from research flights that explored the characteristics of an ice-contaminated tailplane using various simulated ice shapes attached to the leading edge of the horizontal tailplane. A clean leading edge provided the baseline case, then three ice shapes were flown in order of increasing severity. Flight tests included both steady state and dynamic maneuvers. The steady state points were 1G wings level and steady heading sideslips. The primary dynamic maneuvers were pushovers to various G-levels; elevator doublets; and thrust transitions. These maneuvers were conducted for a full range of flap positions and aircraft angle of attack where possible. The analysis of this data set has clearly demonstrated the detrimental effects of ice contamination on aircraft stability and controllability. Paths to tailplane stall were revealed through parameter isolation and transition studies. These paths are (1) increasing ice shape severity, (2) increasing flap deflection, (3) high or low speeds, depending on whether the aircraft is in a steady state (high speed) or pushover maneuver (low speed), and (4) increasing thrust. The flight research effort was very comprehensive, but did not examine effects of tailplane design and location, or other aircraft geometry configuration effects. However, this effort provided the role of some of the parameters in promoting tailplane stall. The lessons learned will provide guidance to regulatory agencies, aircraft manufacturers, and operators on ice-contaminated tailplane stall in the effort to increase aviation safety and reduce the fatal accident rate.

Using GPS telemetry to determine roadways most susceptible to deer-vehicle collisions

USGS Publications Warehouse

Kramer, David W.; Prebyl, Thomas J.; Stickles, James H.; Osborn, David A.; Irwin, Brian J.; Nibbelink, Nathan P.; Warren, Robert J.; Miller, Karl V.

2016-01-01

More than 1 million wildlife-vehicle collisions occur annually in the United States. The majority of these accidents involve white-tailed deer (Odocoileus virginianus) and result in >US $4.6 billion in damage and >200 human fatalities. Prior research has used collision locations to assess sitespecific as well as landscape features that contribute to risk of deer-vehicle collisions. As an alternative approach, we calculated road-crossing locations from 25 GPS-instrumented white-tailed deer near Madison, Georgia (n=154,131 hourly locations). We identified crossing locations by creating movement paths between subsequent GPS points and then intersecting the paths with road locations. Using AIC model selection, we determined whether 10 local and landscape variables were successful at identifying areas where higher frequencies of deer crossings were likely to occur. Our findings indicate that traffic volume, distance to riparian areas, and the amount of forested area influenced the frequency of road crossings. Roadways that were predominately located in wooded landscapes and 200–300 m from riparian areas were crossed frequently. Additionally, we found that areas of low traffic volume (e.g., county roads) had the highest frequencies of deer crossings. Analyses utilizing only records of deer-vehicle collision locations cannot separate the relative contribution of deer crossing rates and traffic volume. Increased frequency of road crossings by deer in low-traffic, forested areas may lead to a greater risk of deer-vehicle collision than suggested by evaluations of deer-vehicle collision frequency alone.

Altered brain structural connectivity in post-traumatic stress disorder: a diffusion tensor imaging tractography study.

PubMed

Long, Zhiliang; Duan, Xujun; Xie, Bing; Du, Handan; Li, Rong; Xu, Qiang; Wei, Luqing; Zhang, Shao-xiang; Wu, Yi; Gao, Qing; Chen, Huafu

2013-09-25

Post-traumatic stress disorder (PTSD) is characterized by dysfunction of several discrete brain regions such as medial prefrontal gyrus with hypoactivation and amygdala with hyperactivation. However, alterations of large-scale whole brain topological organization of structural networks remain unclear. Seventeen patients with PTSD in motor vehicle accident survivors and 15 normal controls were enrolled in our study. Large-scale structural connectivity network (SCN) was constructed using diffusion tensor tractography, followed by thresholding the mean factional anisotropy matrix of 90 brain regions. Graph theory analysis was then employed to investigate their aberrant topological properties. Both patient and control group showed small-world topology in their SCNs. However, patients with PTSD exhibited abnormal global properties characterized by significantly decreased characteristic shortest path length and normalized characteristic shortest path length. Furthermore, the patient group showed enhanced nodal centralities predominately in salience network including bilateral anterior cingulate and pallidum, and hippocampus/parahippocamus gyrus, and decreased nodal centralities mainly in medial orbital part of superior frontal gyrus. The main limitation of this study is the small sample of PTSD patients, which may lead to decrease the statistic power. Consequently, this study should be considered an exploratory analysis. These results are consistent with the notion that PTSD can be understood by investigating the dysfunction of large-scale, spatially distributed neural networks, and also provide structural evidences for further exploration of neurocircuitry models in PTSD. © 2013 Elsevier B.V. All rights reserved.

Simulation Modeling Requirements for Loss-of-Control Accident Prevention of Turboprop Transport Aircraft

NASA Technical Reports Server (NTRS)

Crider, Dennis; Foster, John V.

2012-01-01

In-flight loss of control remains the leading contributor to aviation accident fatalities, with stall upsets being the leading causal factor. The February 12, 2009. Colgan Air, Inc., Continental Express flight 3407 accident outside Buffalo, New York, brought this issue to the forefront of public consciousness and resulted in recommendations from the National Transportation Safety Board to conduct training that incorporates stalls that are fully developed and develop simulator standards to support such training. In 2010, Congress responded to this accident with Public Law 11-216 (Section 208), which mandates full stall training for Part 121 flight operations. Efforts are currently in progress to develop recommendations on implementation of stall training for airline pilots. The International Committee on Aviation Training in Extended Envelopes (ICATEE) is currently defining simulator fidelity standards that will be necessary for effective stall training. These recommendations will apply to all civil transport aircraft including straight-wing turboprop aircraft. Government-funded research over the previous decade provides a strong foundation for stall/post-stall simulation for swept-wing, conventional tail jets to respond to this mandate, but turboprops present additional and unique modeling challenges. First among these challenges is the effect of power, which can provide enhanced flow attachment behind the propellers. Furthermore, turboprops tend to operate for longer periods in an environment more susceptible to ice. As a result, there have been a significant number of turboprop accidents as a result of the early (lower angle of attack) stalls in icing. The vulnerability of turboprop configurations to icing has led to studies on ice accumulation and the resulting effects on flight behavior. Piloted simulations of these effects have highlighted the important training needs for recognition and mitigation of icing effects, including the reduction of stall margins. This paper addresses simulation modeling requirements that are unique to turboprop transport aircraft and highlights the growing need for aerodynamic models suitable for stall training for these configurations. A review of prominent accidents that involved aerodynamic stall is used to illustrate various modeling features unique to turboprop configurations and the impact of stall behavior on susceptibility to loss of control that has led to new training requirements. This is followed by an overview of stability and control behavior of straight-wing turboprops, the related aerodynamic characteristics, and a summary of recent experimental studies on icing effects. In addition, differences in flight dynamics behavior between swept-wing jets and straight-wing turboprop configurations are discussed to compare and contrast modeling requirements. Specific recommendations for aerodynamic models along with further research needs and data measurements are also provided. 1

49 CFR 655.44 - Post-accident testing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the employer is unable to perform a post-accident test within the required period noted in paragraphs... 49 Transportation 7 2011-10-01 2011-10-01 false Post-accident testing. 655.44 Section 655.44... of Testing § 655.44 Post-accident testing. (a) Accidents. (1) Fatal accidents. (i) As soon as...

41 CFR 101-39.407 - Accident records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Accident records. 101-39...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.4-Accidents and Claims § 101-39.407 Accident records. If GSA's records of vehicle accidents indicate that a particular activity has had an unusually high accident frequency...

The relationship between safety climate and recent accidents: behavioral learning and cognitive attributions.

PubMed

Desai, Vinit M; Roberts, Karlene H; Ciavarelli, Anthony P

2006-01-01

The association between accidents and subsequent work unit safety perceptions was assessed to address cognitive and behavioral changes following accidents. Many studies attempt to predict accident rates using measures of work unit safety, but effects vary considerably. Conversely, this study examined whether recent accidents may be positively associated with work unit safety perceptions, as suggested by behavioral learning mechanisms (increases in safety investments following accidents) or cognitive mechanisms (defensive attributions regarding accident causality). Lagged squadron-level accident experience was correlated with work unit safety perceptions obtained through a 61-question safety climate survey administered to 6,361 individuals in U.S. Navy flight squadrons. Positive associations between minor or intermediately severe accidents and future safety climate scores were found, although no effect was found for major accidents. We suggest that accident history should be considered when examining work unit safety perceptions because recent accidents may be associated with higher safety climate scores. We did not find that this varies systematically with accident severity, and longitudinal research on additional samples is needed to further test this possibility. This research may be used to refine measurement of work unit safety and to examine impacts of accidents or safety violations on workers' cognitive processes and group behavioral changes.

[Analysis of work accidents during the years 1999-2006 in a hospital company in Lombardia].

PubMed

Melloni, P; Antoniazzi, E; Somenzi, V; Galli, L; Fazioli, R; Mottinelli, A; Franzosi, C; Cirla, A M; Gobba, E

2007-01-01

This study describe accidents occurred in the period between 1999 and 2006 in the Hospital of Cremona, in which about 2400 subjects operate. The analysis of Accident Register showed a reduction of about 30% of the total number of accidents during the examined period and a non homogeneous distribution of the various types of accidents. The most frequent accidents were prick (25.8%), trauma (22.9%) and "in itinere" accidents (7.8%). One type of accident has been little considered up to now: the aggressions. Professional nurses were the most frequently involved and the most affected units were those that belong to the Internal Medicine Department. "In itinere" accidents had the longest average prognosis (11.6 days). The repetition of accidents occurred to the same operator hasn't been analysed before now: a professional nurse had nine accidents (of various type) in the seven years considered. Probably the reduction of accident must be attributed to the effectiveness of the prevention activities undertaken during the reviewed period. Biological accidents, for which it was possible to implement prevention programs, have been markedly reduced; it was not the same for "In Itinere" accidents, that depend significantly on external factors that are not easily dismissed.

Secondary school accident reporting in one education authority.

PubMed

Williams, W R; Latif, A H A; Sibert, J

2002-01-01

Secondary schools appear to have very different accident rates when they are compared on the basis of accident report returns. The variation may be as a result of real differences in accident rates or different reporting procedures. This study investigates accident reporting from secondary schools and, in particular, the role of the school nurse. Accident form returns covering a 2-year period were collected for statistical analysis from 13 comprehensive schools in one local education authority in Wales. School sites were visited in the following school year to obtain information about accident records held on site and accident reporting procedures. The main factors determining the number of school accident reports submitted to the education authority relate to differences in recording and reporting procedures, such as the employment of a nurse and the policy of the head teacher/safety officer on submitting accident returns. Accident and emergency department referrals from similar schools may show significant differences in specific injuries and their causes. The level of school accident activity cannot be gauged from reports submitted to the education authority. Lack of incentives for collecting good accident data, in conjunction with the degree of complacency in the current system, suggest that future accident rates and reporting activity are unlikely to change.

A Comparative Analysis of Attitudes on Communication Toward Stem Cell Research and Regenerative Medicine Between the Public and the Scientific Community

PubMed Central

Inoue, Yusuke; Ikka, Tsunakuni; Kishimoto, Atsuo

2018-01-01

Abstract Owing to the rapid progress in stem cell research (SCR) and regenerative medicine (RM), society's expectation and interest in these fields are increasing. For effective communication on issues concerning SCR and RM, surveys for understanding the interests of stakeholders is essential. For this purpose, we conducted a large‐scale survey with 2,160 public responses and 1,115 responses from the member of the Japanese Society for Regenerative Medicine. Results showed that the public is more interested in the post‐realization aspects of RM, such as cost of care, countermeasures for risks and accidents, and clarification of responsibility and liability, than in the scientific aspects; the latter is of greater interest only to scientists. Our data indicate that an increased awareness about RM‐associated social responsibility and regulatory framework is required among scientists, such as those regarding its benefits, potential accidents, abuse, and other social consequences. Awareness regarding the importance of communication and education for scientists are critical to bridge the gaps in the interests of the public and scientists. Stem Cells Translational Medicine 2018;7:251–257 PMID:29372590

How Thailand's greater convergence created sustainable funding for emerging health priorities caused by globalization.

PubMed

Charoenca, Naowarut; Kungskulniti, Nipapun; Mock, Jeremiah; Hamann, Stephen; Vathesatogkit, Prakit

2015-01-01

Global health is shifting gradually from a limited focus on individual communicable disease goals to the formulation of broader sustainable health development goals. A major impediment to this shift is that most low- and middle-income countries (LMICs) have not established adequate sustainable funding for health promotion and health infrastructure. In this article, we analyze how Thailand, a middle-income country, created a mechanism for sustainable funding for health. We analyzed the progression of tobacco control and health promotion policies over the past three decades within the wider political-economic and sociocultural context. We constructed a parallel longitudinal analysis of statistical data on one emerging priority - road accidents - to determine whether policy shifts resulted in reduced injuries, hospitalizations and deaths. In Thailand, the convergence of priorities among national interest groups for sustainable health development created an opportunity to use domestic tax policy and to create a semi-autonomous foundation (ThaiHealth) to address a range of pressing health priorities, including programs that substantially reduced road accidents. Thailand's strategic process to develop a domestic mechanism for sustainable funding for health may provide LMICs with a roadmap to address emerging health priorities, especially those caused by modernization and globalization.

VVER Reactor Safety in Eastern Europe and Former Soviet Union

NASA Astrophysics Data System (ADS)

Papadopoulou, Demetra

2012-02-01

VVER Soviet-designed reactors that operate in Eastern Europe and former Soviet republics have heightened international concern for years due to major safety deficiencies. The governments of countries with VVER reactors have invested millions of dollars toward improving the safety of their nuclear power plants. Most of these reactors will continue to operate for the foreseeable future since they provide urgently-needed electrical power. Given this situation, this paper assesses the radiological consequences of a major nuclear accident in Eastern Europe. The paper also chronicles the efforts launched by the international nuclear community to improve the safety of the reactors and notes the progress made so far through extensive collaborative efforts in Armenia, Bulgaria, the Czech Republic, Hungary, Kazakhstan, Lithuania, Russia, Slovakia, and Ukraine to reduce the risks of nuclear accidents. Western scientific and technical staff collaborated with these countries to improve the safety of their reactor operations by strengthening the ability of the regulator to perform its oversight function, installing safety equipment and technologies, investing time in safety training, and working diligently to establish an enduring safety culture. Still, continued safety improvement efforts are necessary to ensure safe operating practices and achieve timely phase-out of older plants.

[Driving ability and dementia].

PubMed

Lukas, Albert; Nikolaus, Thorsten

2009-06-01

Physiological changes in cognitive competence in the elderly are clearly different to pathological changes such as dementia. Diagnosing dementia is not to be equated with absolute driving inability. During the course of dementia, the risk of an accident increases significantly. Detailed observation and regular checks serve to determine the appropriate time to hand in the driving licence. The basis of each decision should be a detailed history of the person and his or her immediate family. Attention should be paid to incorrect driving practise, unusual behaviour and uncertainty whilst driving as well as involvement in any accidents. An MMSE score below 24 or a CCT score up to 3 should result in an additional assessment being carried out, e.g. neuro-psychological tests, driving simulator or, if necessary on-road tests performed with specialists. Also helpful is the determination of functional status. Limitations in ADL or IADL function normally indicate an advanced stage of dementia. Due to the progression of the illness, the possibility of handing in the driving licence should be addressed as soon as possible. In this context, it is helpful to consider alternative forms of transportation. Individual wishes and needs must to be balanced against general road safety requirements.

Occupational accidents aboard merchant ships

PubMed Central

Hansen, H; Nielsen, D; Frydenberg, M

2002-01-01

Objectives: To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. Methods: The study is a historical follow up on occupational accidents among crew aboard Danish merchant ships in the period 1993–7. Data were extracted from the Danish Maritime Authority and insurance data. Exact data on time at risk were available. Results: A total of 1993 accidents were identified during a total of 31 140 years at sea. Among these, 209 accidents resulted in permanent disability of 5% or more, and 27 were fatal. The mean risk of having an occupational accident was 6.4/100 years at sea and the risk of an accident causing a permanent disability of 5% or more was 0.67/100 years aboard. Relative risks for notified accidents and accidents causing permanent disability of 5% or more were calculated in a multivariate analysis including ship type, occupation, age, time on board, change of ship since last employment period, and nationality. Foreigners had a considerably lower recorded rate of accidents than Danish citizens. Age was a major risk factor for accidents causing permanent disability. Change of ship and the first period aboard a particular ship were identified as risk factors. Walking from one place to another aboard the ship caused serious accidents. The most serious accidents happened on deck. Conclusions: It was possible to clearly identify work situations and specific risk factors for accidents aboard merchant ships. Most accidents happened while performing daily routine duties. Preventive measures should focus on workplace instructions for all important functions aboard and also on the prevention of accidents caused by walking around aboard the ship. PMID:11850550

Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilization.

PubMed

Simpson, Rachel M; Bruno, Andrew E; Chen, Runpu; Lott, Kaylen; Tylec, Brianna L; Bard, Jonathan E; Sun, Yijun; Buck, Michael J; Read, Laurie K

2017-07-27

Uridine insertion/deletion RNA editing is an essential process in kinetoplastid parasites whereby mitochondrial mRNAs are modified through the specific insertion and deletion of uridines to generate functional open reading frames, many of which encode components of the mitochondrial respiratory chain. The roles of numerous non-enzymatic editing factors have remained opaque given the limitations of conventional methods to interrogate the order and mechanism by which editing progresses and thus roles of individual proteins. Here, we examined whole populations of partially edited sequences using high throughput sequencing and a novel bioinformatic platform, the Trypanosome RNA Editing Alignment Tool (TREAT), to elucidate the roles of three proteins in the RNA Editing Mediator Complex (REMC). We determined that the factors examined function in the progression of editing through a gRNA; however, they have distinct roles and REMC is likely heterogeneous in composition. We provide the first evidence that editing can proceed through numerous paths within a single gRNA and that non-linear modifications are essential, generating commonly observed junction regions. Our data support a model in which RNA editing is executed via multiple paths that necessitate successive re-modification of junction regions facilitated, in part, by the REMC variant containing TbRGG2 and MRB8180. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.