Science.gov

Sample records for accidents involving large

  1. Differences in rural and urban driver-injury severities in accidents involving large-trucks: an exploratory analysis.

    PubMed

    Khorashadi, Ahmad; Niemeier, Debbie; Shankar, Venky; Mannering, Fred

    2005-09-01

    This study explores the differences between urban and rural driver injuries (both passenger-vehicle and large-truck driver injuries) in accidents that involve large trucks (in excess of 10,000 pounds). Using 4 years of California accident data, and considering four driver-injury severity categories (no injury, complaint of pain, visible injury, and severe/fatal injury), a multinomial logit analysis of the data was conducted. Significant differences with respect to various risk factors including driver, vehicle, environmental, road geometry and traffic characteristics were found to exist between urban and rural models. For example, in rural accidents involving tractor-trailer combinations, the probability of drivers' injuries being severe/fatal increased about 26% relative to accidents involving single-unit trucks. In urban areas, this same probability increased nearly 700%. In accidents where alcohol or drug use was identified as being the primary cause of the accident, the probability of severe/fatal injury increased roughly 250% percent in rural areas and nearly 800% in urban areas. While many of the same variables were found to be significant in both rural and urban models (although often with quite different impact), there were 13 variables that significantly influenced driver-injury severity in rural but not urban areas, and 17 variables that significantly influenced driver-injury severity in urban but not rural areas. We speculate that the significant differences between rural and urban injury severities may be at least partially attributable to the different perceptual, cognitive and response demands placed on drivers in rural versus urban areas.

  2. An analysis of aircraft accidents involving fires

    NASA Technical Reports Server (NTRS)

    Lucha, G. V.; Robertson, M. A.; Schooley, F. A.

    1975-01-01

    All U. S. Air Carrier accidents between 1963 and 1974 were studied to assess the extent of total personnel and aircraft damage which occurred in accidents and in accidents involving fire. Published accident reports and NTSB investigators' factual backup files were the primary sources of data. Although it was frequently not possible to assess the relative extent of fire-caused damage versus impact damage using the available data, the study established upper and lower bounds for deaths and damage due specifically to fire. In 12 years there were 122 accidents which involved airframe fires. Eighty-seven percent of the fires occurred after impact, and fuel leakage from ruptured tanks or severed lines was the most frequently cited cause. A cost analysis was performed for 300 serious accidents, including 92 serious accidents which involved fire. Personal injury costs were outside the scope of the cost analysis, but data on personnel injury judgements as well as settlements received from the CAB are included for reference.

  3. Truck accident involving unirradiated nuclear fuel

    SciTech Connect

    Carlson, R.W.; Fischer, L.E.

    1992-07-01

    In the early morning of Dec. 16, 1991, a severe accident occurred when a passenger vehicle traveling in the wrong direction collided with a tractor trailer carrying 24 nuclear fuel assemblies in 12 containers on Interstate 1-91 in Springfield, Massachusetts. This paper documents the mechanical circumstances of the accident and the physical environment to which the containers were exposed and the response of the containers and their contents. The accident involved four impacts where the truck was struck by the car, impacted on the center guardrail, impacted on the outer concrete barrier and came to rest against the center guardrail. The impacts were followed by a fire that began in the engine compartment, spread to the.tractor and cab, and eventually spread to the trailer and payload. The fire lasted for about three hours and the packages were involved in the fire for about two hours. As a result of the fire, the tractor-trailer was completely destroyed and the packages were exposed to flames with temperatures between 1300{degrees}F and 1800{degrees}F. The fuel assemblies remained intact during the accident and there was no release of any radioactive material during the accident. This was a very severe accident; however, the injuries were minor and at no time was the public health and safety at risk.

  4. Truck accident involving unirradiated nuclear fuel

    SciTech Connect

    Carlson, R.W.; Fischer, L.E.

    1992-07-01

    In the early morning of Dec. 16, 1991, a severe accident occurred when a passenger vehicle traveling in the wrong direction collided with a tractor trailer carrying 24 nuclear fuel assemblies in 12 containers on Interstate 1-91 in Springfield, Massachusetts. This paper documents the mechanical circumstances of the accident and the physical environment to which the containers were exposed and the response of the containers and their contents. The accident involved four impacts where the truck was struck by the car, impacted on the center guardrail, impacted on the outer concrete barrier and came to rest against the center guardrail. The impacts were followed by a fire that began in the engine compartment, spread to the.tractor and cab, and eventually spread to the trailer and payload. The fire lasted for about three hours and the packages were involved in the fire for about two hours. As a result of the fire, the tractor-trailer was completely destroyed and the packages were exposed to flames with temperatures between 1300[degrees]F and 1800[degrees]F. The fuel assemblies remained intact during the accident and there was no release of any radioactive material during the accident. This was a very severe accident; however, the injuries were minor and at no time was the public health and safety at risk.

  5. Prediction of police officers' traffic accident involvement using behavioral observations.

    PubMed

    Gully, S M; Whitney, D J; Vanosdall, F E

    1995-06-01

    The current study used scores on the Driver Performance Measurement (DPM) test and data gathered over four years on accident type and frequency from 47 police officers to provide evidence that cognitive-behavioral observations of driving patterns can lead to predictions of subsequent accident involvement. Results indicate that after controlling for age and experience, scores on the DPM test predicted involvement in preventable accidents but not unpreventable accidents. Implications for future research involving the observation of cognitive-behavioral sequences are discussed. PMID:7639919

  6. Tragic Car Accident Involves ESO Employees

    NASA Astrophysics Data System (ADS)

    2000-06-01

    Saturday, May 27, turned into a tragic day for ESO. The team installing TIMMI2 at La Silla, went on an excursion to the Elqui valley, 70 km east of the city of La Serena and suffered a serious car accident, crashing against another car driving from the opposite direction.

  7. Transportation accidents/incidents involving radioactive materials (1971--1991)

    SciTech Connect

    Cashwell, C. E.; McClure, J. D.

    1992-01-01

    The Radioactive Materials Incident Report (RMIR) database contains information on transportation-related accidents and incidents involving radioactive materials that have occurred in the United States. The RMIR was developed at Sandia National Laboratories (SNL) to support its research and development program efforts for the US Department of Energy (DOE). This paper will address the following topics: background information on the regulations and process for reporting a hazardous materials transportation incident, overview data of radioactive materials transportation accidents and incidents, and additional information and summary data on how packagings have performed in accident conditions.

  8. Who's Liable? Accidents Involving Young Children.

    ERIC Educational Resources Information Center

    Beebe, Robert J.

    1994-01-01

    Over the past few years both administrators and teachers have found themselves involved in an increasing number of law suits. When students are injured on school grounds, parents often place the blame of negligence on the teacher, so many teachers find themselves involved in lengthy court battles over the issue of liability. Teachers and…

  9. The Epidemiology and Prevention of Traffic Accidents Involving Child Pedestrians

    PubMed Central

    Read, John H.; Bradley, Eleanor J.; Morison, Joan D.; Lewall, David; Clarke, David A.

    1963-01-01

    A study of 713 motor vehicle accidents involving 749 children in the city of Vancouver is reported. A control group of 110 children who did not have accidents was included in the concurrent study. Factors investigated were the driver, the vehicle, the weather, the time of day, the day of week, the month, the width of roadway, the location of the accident, the child's age, sex, personality, school record, and family background, the type of injury, and the ambulance and hospital service received. Boys were more commonly involved than girls, and most accidents occurred in the 3 to 7 year age group. Head injuries prevailed in the younger age groups and decreased steadily with the age of the child. Specific epidemic areas in the city were identified and selective enforcement was suggested as a possible countermeasure. Hospital records seldom provided a detailed history of the events leading up to the accident. In order to apply the preventive techniques of education and enforcement it was suggested that in each pedestrian traffic accident the driver should be required to accompany the victim to the site of medical care. ImagesFig. 4 PMID:14055829

  10. The five-factor model, conscientiousness, and driving accident involvement.

    PubMed

    Arthur, W; Graziano, W G

    1996-09-01

    Personality researchers and theorists are approaching consensus on the basic structure and constructs of personality. Despite the apparent consensus on the emergent five-factor model (Goldberg, 1992, 1993), less is known about external correlates of separate factors. This research examined the relations between Conscientiousness, one dimension of the model, and driving accident involvement. Using multiple measures in independent samples drawn from college students (N = 227) and a temporary employment agency (N = 250), the results generally demonstrate a significant inverse relation between Conscientiousness and driving accident involvement; individuals who rate themselves as more self-disciplined, responsible, reliable, and dependable are less likely to be involved in driving accidents than those who rate themselves lower on these attributes. The findings are consistent with other research demonstrating the relations among Conscientiousness and other tasks and job performance. Suggestions for future research are discussed. PMID:8776881

  11. Drinking reasons, drinking locations, and automobile accident involvement among collegians.

    PubMed

    Pang, M G; Wells-Parker, E; McMillen, D L

    1989-03-01

    Multiple regression analysis was used to examine the relationship of five drinking reason factors to drinking locations and consumption variables within a random sample of drinking college students surveyed by telephone. Hypotheses relating self-reported accident involvement after drinking and two specific reason factors - Opposite Sex/Drunkenness and Pleasure - were tested. Both Pleasure and Opposite Sex/Drunkenness were directly related to quantity consumed and to drinking in several away-from-home locations. Opposite Sex/Drunkenness reasons and frequency of drinking in cars significantly contributed to identifying males who reported accident involvement following drinking.

  12. Drug Use among Iranian Drivers Involved in Fatal Car Accidents

    PubMed Central

    Assari, Shervin; Moghani Lankarani, Maryam; Dejman, Masoumeh; Farnia, Marzieh; Alasvand, Ramin; Sehat, Mahmood; Roshanpazooh, Mohsen; Tavakoli, Mahmood; Jafari, Firoozeh; Ahmadi, Khodabakhsh

    2014-01-01

    Background: Although the problem of substance use among drivers is not limited to certain parts of the world, most epidemiological reports on this topic have been published from industrial world. Aim: To investigate pattern of drug use among Iranian drivers who were involved in fatal road accidents. Methods: This study enrolled 51 Iranian adults who were involved in fatal vehicle accidents and were imprisoned thereafter. Data came from a national survey of drug abuse that was done among Iranian prisoners. The survey collected data at the entry to seven prisons in different regions of the country during a 4-month period in 2008. Self-reported lifetime, last year, and last month drug use was measured. Commercial substance screening tests were applied to detect recent substance use (opioids, cannabinoids, methamphetamines, and benzodiazepines). Results: The commercial substance screening test showed three distinct patterns of recent illicit drug use: opioids (37.3%), cannabinoids (2.0%), opioids and cannabinoids (13.7%). 29.4% were also positive for benzodiazepines. The substance use screening test detected 23.5% of participants who had used drugs but did not disclose any substance use. Conclusion: Opioids are the most common illicit drugs being used by Iranian drivers who are involved in fatal car accidents. The high rate of substance use prior to fatal car accidents in Iran advocates for the need for drug use control policies and programs as major strategies for injury prevention in Iran. There is also a need for substance screening among all drivers involved in fatal car accidents in Iran, as more than 20% of users may not disclose substance use. PMID:25221521

  13. A comparison of the hazard perception ability of accident-involved and accident-free motorcycle riders.

    PubMed

    Cheng, Andy S K; Ng, Terry C K; Lee, Hoe C

    2011-07-01

    Hazard perception is the ability to read the road and is closely related to involvement in traffic accidents. It consists of both cognitive and behavioral components. Within the cognitive component, visual attention is an important function of driving whereas driving behavior, which represents the behavioral component, can affect the hazard perception of the driver. Motorcycle riders are the most vulnerable types of road user. The primary purpose of this study was to deepen our understanding of the correlation of different subtypes of visual attention and driving violation behaviors and their effect on hazard perception between accident-free and accident-involved motorcycle riders. Sixty-three accident-free and 46 accident-involved motorcycle riders undertook four neuropsychological tests of attention (Digit Vigilance Test, Color Trails Test-1, Color Trails Test-2, and Symbol Digit Modalities Test), filled out the Chinese Motorcycle Rider Driving Violation (CMRDV) Questionnaire, and viewed a road-user-based hazard situation with an eye-tracking system to record the response latencies to potentially dangerous traffic situations. The results showed that both the divided and selective attention of accident-involved motorcycle riders were significantly inferior to those of accident-free motorcycle riders, and that accident-involved riders exhibited significantly higher driving violation behaviors and took longer to identify hazardous situations compared to their accident-free counterparts. However, the results of the regression analysis showed that aggressive driving violation CMRDV score significantly predicted hazard perception and accident involvement of motorcycle riders. Given that all participants were mature and experienced motorcycle riders, the most plausible explanation for the differences between them is their driving style (influenced by an undesirable driving attitude), rather than skill deficits per se. The present study points to the importance of

  14. Health Physics Code System for Evaluating Accidents Involving Radioactive Materials.

    SciTech Connect

    2014-10-01

    Version 03 The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculational tool for evaluating accidents involving radioactive materials. HOTSPOT codes provide a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. The developer's website is: http://www.llnl.gov/nhi/hotspot/. Four general programs, PLUME, EXPLOSION, FIRE, and RESUSPENSION, calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosive release, fuel fire, or an area contamination event. Additional programs deal specifically with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. The FIDLER program can calibrate radiation survey instruments for ground survey measurements and initial screening of personnel for possible plutonium uptake in the lung. The HOTSPOT codes are fast, portable, easy to use, and fully documented in electronic help files. HOTSPOT supports color high resolution monitors and printers for concentration plots and contours. The codes have been extensively used by the DOS community since 1985. Tables and graphical output can be directed to the computer screen, printer, or a disk file. The graphical output consists of dose and ground contamination as a function of plume centerline downwind distance, and radiation dose and ground contamination contours. Users have the option of displaying scenario text on the plots. HOTSPOT 3.0.1 fixes three significant Windows 7 issues: � Executable installed properly under "Program Files/HotSpot 3.0". Installation package now smaller: removed dependency on older Windows DLL files which previously needed to \\ � Forms now properly scale based on DPI instead of font for users who change their screen resolution to something other than 100%. This is a more common feature in Windows 7.

  15. Health Physics Code System for Evaluating Accidents Involving Radioactive Materials.

    2014-10-01

    Version 03 The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculational tool for evaluating accidents involving radioactive materials. HOTSPOT codes provide a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. The developer's website is: http://www.llnl.gov/nhi/hotspot/. Four general programs, PLUME, EXPLOSION, FIRE, and RESUSPENSION, calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosivemore » release, fuel fire, or an area contamination event. Additional programs deal specifically with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. The FIDLER program can calibrate radiation survey instruments for ground survey measurements and initial screening of personnel for possible plutonium uptake in the lung. The HOTSPOT codes are fast, portable, easy to use, and fully documented in electronic help files. HOTSPOT supports color high resolution monitors and printers for concentration plots and contours. The codes have been extensively used by the DOS community since 1985. Tables and graphical output can be directed to the computer screen, printer, or a disk file. The graphical output consists of dose and ground contamination as a function of plume centerline downwind distance, and radiation dose and ground contamination contours. Users have the option of displaying scenario text on the plots. HOTSPOT 3.0.1 fixes three significant Windows 7 issues: � Executable installed properly under "Program Files/HotSpot 3.0". Installation package now smaller: removed dependency on older Windows DLL files which previously needed to \\ � Forms now properly scale based on DPI instead of font for users who change their screen resolution to something other than 100%. This is a more common feature in Windows 7

  16. Zagreb and Tenerife: Airline Accidents Involving Linguistic Factors

    ERIC Educational Resources Information Center

    Cookson, Simon

    2009-01-01

    The International Civil Aviation Organization (ICAO) is currently implementing a program to improve the language proficiency of pilots and air traffic controllers worldwide. In justifying the program, ICAO has cited a number of airline accidents that were at least partly caused by language factors. Two accidents cited by ICAO are analysed in this…

  17. Evacuation areas for transportation accidents involving propellant tank pressure bursts

    NASA Technical Reports Server (NTRS)

    Siewert, R. D.

    1972-01-01

    Evacuation areas are defined for those transportation accidents where volatile chemical propellant tanks are exposed to fire in the wreckage and eventually explode with consequent risks from fragments in surrounding populated areas. An evacuation area with a minimum radius of 600 m (2000 ft) is recommended to limit the statistical probability of fatality to one in 100 such accidents. The result was made possible by the derivation of a distribution function of distances reached by fragments from bursting chemical car tanks. Data concerning fragments was obtained from reports or tank car pressure bursts between 1958 and 1971.

  18. Temperature of aircraft cargo flame exposure during accidents involving fuel spills

    SciTech Connect

    Mansfield, J.A.

    1993-01-01

    This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

  19. Accident involvement among learner drivers--an analysis of the consequences of supervised practice.

    PubMed

    Gregersen, Nils Petter; Nyberg, Anders; Berg, Hans-Yngve

    2003-09-01

    It is a well-known fact that experience is important for safe driving. Previously, this presented a problem since experience was mostly gained during the most dangerous period of driving-the first years with a licence. In many countries, this "experience paradox" has been addressed by providing increased opportunities to gain experience through supervised practice. One question, however, which still needs to be answered is what has been lost and what has been gained through supervised practice. Does this method lead to fewer accidents after licensing and/or has the number of accidents in driving practice increased? There were three aims in the study. The first was to calculate the size of the accident problem in terms of the number of accidents, health risk and accident risk during practising. The second aim was to evaluate the solution of the "experience paradox" that supervised practice suggests by calculating the costs in terms of accidents during driving practice and the benefits in terms of reduced accident involvement after obtaining a licence. The third aim was to analyse conflict types that occur during driving practice. National register data on licence holders and police-reported injury accidents and self-reported exposure were used. The results show that during the period 1994-2000, 444 driving practice injury accidents were registered, compared to 13657 accidents during the first 2 years with a licence. The health risk during the period after licensing was 33 times higher and the accident risk 10 times higher than the corresponding risk during practice. The cost-benefit analysis showed that the benefits in terms of accident reduction after licensing were 30 times higher than the costs in terms of driving practice accidents. It is recommended that measures to reduce such accidents should focus on better education of the lay instructor, but not on introducing measures to reduce the amount of lay-instructed practice. PMID:12850073

  20. 49 CFR 234.7 - Accidents involving grade crossing signal failure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (activation failure report) and 49 CFR 225.11 (accident/ incident report). (b) Each telephone report must... 49 Transportation 4 2010-10-01 2010-10-01 false Accidents involving grade crossing signal failure... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE...

  1. 49 CFR 234.7 - Accidents involving grade crossing signal failure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (activation failure report) and 49 CFR 225.11 (accident/ incident report). (b) Each telephone report must... 49 Transportation 4 2011-10-01 2011-10-01 false Accidents involving grade crossing signal failure... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE...

  2. Human Factors in Accidents Involving Remotely Piloted Aircraft

    NASA Technical Reports Server (NTRS)

    Merlin, Peter William

    2013-01-01

    This presentation examines human factors that contribute to RPA mishaps and provides analysis of lessons learned. RPA accident data from U.S. military and government agencies were reviewed and analyzed to identify human factors issues. Common contributors to RPA mishaps fell into several major categories: cognitive factors (pilot workload), physiological factors (fatigue and stress), environmental factors (situational awareness), staffing factors (training and crew coordination), and design factors (human machine interface).

  3. Protective Behaviour of Citizens to Transport Accidents Involving Hazardous Materials: A Discrete Choice Experiment Applied to Populated Areas nearby Waterways

    PubMed Central

    de Bekker-Grob, Esther W.; Bergstra, Arnold D.; Bliemer, Michiel C. J.; Trijssenaar-Buhre, Inge J. M.; Burdorf, Alex

    2015-01-01

    Background To improve the information for and preparation of citizens at risk to hazardous material transport accidents, a first important step is to determine how different characteristics of hazardous material transport accidents will influence citizens’ protective behaviour. However, quantitative studies investigating citizens’ protective behaviour in case of hazardous material transport accidents are scarce. Methods A discrete choice experiment was conducted among subjects (19–64 years) living in the direct vicinity of a large waterway. Scenarios were described by three transport accident characteristics: odour perception, smoke/vapour perception, and the proportion of people in the environment that were leaving at their own discretion. Subjects were asked to consider each scenario as realistic and to choose the alternative that was most appealing to them: staying, seeking shelter, or escaping. A panel error component model was used to quantify how different transport accident characteristics influenced subjects’ protective behaviour. Results The response was 44% (881/1,994). The predicted probability that a subject would stay ranged from 1% in case of a severe looking accident till 62% in case of a mild looking accident. All three transport accident characteristics proved to influence protective behaviour. Particularly a perception of strong ammonia or mercaptan odours and visible smoke/vapour close to citizens had the strongest positive influence on escaping. In general, ‘escaping’ was more preferred than ‘seeking shelter’, although stated preference heterogeneity among subjects for these protective behaviour options was substantial. Males were less willing to seek shelter than females, whereas elderly people were more willing to escape than younger people. Conclusion Various characteristics of transport accident involving hazardous materials influence subjects’ protective behaviour. The preference heterogeneity shows that information needs

  4. A statistical description of the types and severities of accidents involving tractor semi-trailers

    SciTech Connect

    Clauss, D.B.; Wilson, R.K.; Blower, D.F.; Campbell, K.L.

    1994-06-01

    This report provides a statistical description of the types and severities of tractor semi-trailer accidents involving at least one fatality. The data were developed for use in risk assessments of hazardous materials transportation. Several accident databases were reviewed to determine their suitability to the task. The TIFA (Trucks Involved in Fatal Accidents) database created at the University of Michigan Transportation Research Institute was extensively utilized. Supplementary data on collision and fire severity, which was not available in the TIFA database, were obtained by reviewing police reports for selected TIFA accidents. The results are described in terms of frequencies of different accident types and cumulative distribution functions for the peak contact velocity, rollover skid distance, fire temperature, fire size, fire separation, and fire duration.

  5. A highway accident involving unirradiated nuclear fuel in Springfield, Massachusetts, on December 16, 1991

    SciTech Connect

    Carlson, R.W.; Fischer, L.E.

    1992-06-01

    In the early morning of Dec. 16, 1991, a severe accident occurred when a passenger vehicle traveling in the wrong direction collided with a tractor trailer carrying 24 unirradiated nuclear fuel assemblies in 12 containers on Interstate I-91 in Springfield, Massachusetts. The purpose of this report is to document the mechanical circumstances of the severe accident, confirm the nature and quantity of the radioactive materials involved, and assess the physical environment to which the containers were exposed and the response of the containers and their contents. The report consists of five major sections. The first section describes the circumstances and conditions of the accident and the finding of facts. The second describes the containers, the unirradiated nuclear fuel assemblies, and the tie down arrangement used for the trailer. The third describes the damage sustained during the accident to the tractor, trailer, containers, and unirradiated nuclear fuel assemblies. The fourth evaluates the accident environment and its effects on the containers and their contents. The final section gives conclusions derived from the analysis and fact finding investigation. During this severe accident, only minor injuries occurred, and at no time was the public health and safety at risk.

  6. Guidelines for the management of accidents involving microorganisms: a WHO Memorandum*

    PubMed Central

    1980-01-01

    The response to an emergency resulting from an accident involving microorganisms, whether in a laboratory or during needs to be graded according to the degree of hazard to human or animal health created by the circumstances of the accident and the properties of the organisms concerned. A categorization of microorganisms by risk groups is proposed for the purposes of accident management, and the factors influencing assignment to risk groups are described. Organizational responsibilities at government health authority and local levels are outlined and emphasis is placed on contingency planning. Medical surveillance is proposed for persons who work in laboratories with dangerous microorganisms, as a means of recognizing accidents that might otherwise go undetected. The response to exposure in a laboratory or transport-associated accident includes emergency safety measures at the site, hazard assessment, and action by the public health or veterinary authorities. The management of exposed persons is considered in relation to the immediate post-exposure period, the potential incubation period, and the onset of illness. Prophylactic treatment, surveillance, and the transport and isolation of infected persons are described. A distinction is drawn between the consequences of accidents recognized at the time of their occurrence and those that are only recognized by onset of illness in the exposed persons. PMID:6994911

  7. 49 CFR 234.7 - Accidents involving grade crossing signal failure.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Reports and Plans § 234.7 Accidents involving... railroad equipment and an automobile, bus, truck, motorcycle, bicycle, farm vehicle, or pedestrian at...

  8. 49 CFR 234.7 - Accidents involving grade crossing signal failure.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... be filed with FRA pursuant to § 234.9 of this part (activation failure report) and 49 CFR 225.11... 49 Transportation 4 2013-10-01 2013-10-01 false Accidents involving grade crossing signal failure... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL...

  9. 49 CFR 234.7 - Accidents involving grade crossing signal failure.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... be filed with FRA pursuant to § 234.9 of this part (activation failure report) and 49 CFR 225.11... 49 Transportation 4 2012-10-01 2012-10-01 false Accidents involving grade crossing signal failure... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL...

  10. Anatomy of Sodium Hypochlorite Accidents Involving Facial Ecchymosis – A Review

    PubMed Central

    Zhu, Wan-chun; Gyamfi, Jacqueline; Niu, Li-na; Schoeffel, G. John; Liu, Si-ying; Santarcangelo, Filippo; Khan, Sara; Tay, Kelvin C-Y.; Pashley, David H.; Tay, Franklin R.

    2013-01-01

    Objectives Root canal treatment forms an essential part of general dental practice. Sodium hypochlorite (NaOCl) is the most commonly used irrigant in endodontics due to its ability to dissolve organic soft tissues in the root canal system and its action as a potent antimicrobial agent. Although NaOCl accidents created by extrusion of the irrigant through root apices are relatively rare and are seldom life-threatening, they do create substantial morbidity when they occur. Methods To date, NaOCl accidents have only been published as isolated case reports. Although previous studies have attempted to summarise the symptoms involved in these case reports, there was no endeavor to analyse the distribution of soft tissue distribution in those reports. In this review, the anatomy of a classical NaOCl accident that involves facial swelling and ecchymosis is discussed. Results By summarising the facial manifestations presented in previous case reports, a novel hypothesis that involves intravenous infusion of extruded NaOCl into the facial vein via non-collapsible venous sinusoids within the cancellous bone is presented. Conclusions Understanding the mechanism involved in precipitating a classic NaOCl accident will enable the profession to make the best decision regarding the choice of irrigant delivery techniques in root canal débridement, and for manufacturers to design and improve their irrigation systems to achieve maximum safety and efficient cleanliness of the root canal system. PMID:23994710

  11. 31 CFR 576.508 - Judicial process in legal proceedings involving ecological accidents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Judicial process in legal proceedings involving ecological accidents. 576.508 Section 576.508 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  12. 31 CFR 576.508 - Judicial process in legal proceedings involving ecological accidents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Judicial process in legal proceedings involving ecological accidents. 576.508 Section 576.508 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  13. 31 CFR 576.508 - Judicial process in legal proceedings involving ecological accidents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Judicial process in legal proceedings involving ecological accidents. 576.508 Section 576.508 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  14. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect

    Not Available

    1999-01-01

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  15. A Comprehensive Review of Rollover Accidents Involving Vehicles Equipped with Electronic Stability Control (ESC) Systems

    PubMed Central

    Padmanaban, Jeya; Shields, Leland E.; Scheibe, Robert R.; Eyges, Vitaly E.

    2008-01-01

    This study investigated 478 police accident reports from 9 states to examine and characterize rollover crashes involving ESC-equipped vehicles. The focus was on the sequence of critical events leading to loss of control and rollover, and the interactions between the accident, driver, and environment. Results show that, while ESC is effective in reducing loss of control leading to certain rollover crashes, its effectiveness is diminished in others, particularly when the vehicle departs the roadway or when environmental factors such as slick road conditions or driver factors such as speeding, distraction, fatigue, impairment, or overcorrection are present. PMID:19026219

  16. 36 CFR 3.5 - Do I have to report an accident involving a vessel to the National Park Service?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... accident involving a vessel to the National Park Service? 3.5 Section 3.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.5 Do I have to report an accident involving a vessel to the National Park Service? (a) The operator of a...

  17. 36 CFR 3.5 - Do I have to report an accident involving a vessel to the National Park Service?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... accident involving a vessel to the National Park Service? 3.5 Section 3.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.5 Do I have to report an accident involving a vessel to the National Park Service? (a) The operator of a...

  18. 36 CFR 3.5 - Do I have to report an accident involving a vessel to the National Park Service?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... accident involving a vessel to the National Park Service? 3.5 Section 3.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.5 Do I have to report an accident involving a vessel to the National Park Service? (a) The operator of a...

  19. 36 CFR 3.5 - Do I have to report an accident involving a vessel to the National Park Service?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... accident involving a vessel to the National Park Service? 3.5 Section 3.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.5 Do I have to report an accident involving a vessel to the National Park Service? (a) The operator of a...

  20. 36 CFR 3.5 - Do I have to report an accident involving a vessel to the National Park Service?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accident involving a vessel to the National Park Service? 3.5 Section 3.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.5 Do I have to report an accident involving a vessel to the National Park Service? (a) The operator of a...

  1. Accidents at Work and Costs Analysis: A Field Study in a Large Italian Company

    PubMed Central

    BATTAGLIA, Massimo; FREY, Marco; PASSETTI, Emilio

    2014-01-01

    Accidents at work are still a heavy burden in social and economic terms, and action to improve health and safety standards at work offers great potential gains not only to employers, but also to individuals and society as a whole. However, companies often are not interested to measure the costs of accidents even if cost information may facilitate preventive occupational health and safety management initiatives. The field study, carried out in a large Italian company, illustrates technical and organisational aspects associated with the implementation of an accident costs analysis tool. The results indicate that the implementation (and the use) of the tool requires a considerable commitment by the company, that accident costs analysis should serve to reinforce the importance of health and safety prevention and that the economic dimension of accidents is substantial. The study also suggests practical ways to facilitate the implementation and the moral acceptance of the accounting technology. PMID:24869894

  2. [Analysis of accidents for magnetically induced displacement of the large ferromagnetic material in magnetic resonance systems].

    PubMed

    Yamatani, Yuya; Doi, Tsukasa; Ueyama, Tsuyoshi; Nishiki, Shigeo; Ogura, Akio; Kawamitsu, Hideaki; Tsuchihashi, Toshio; Okuaki, Tomoyuki; Matsuda, Tsuyoshi

    2013-01-01

    To improve magnetic resonance (MR) safety, we surveyed the accidents caused by large ferromagnetic materials brought into MR systems accidentally. We sent a questionnaire to 700 Japanese medical institutions and received 405 valid responses (58%). A total of 97 accidents in 77 institutions were observed and we analyzed them regarding incidental rate, the detail situation and environmental factors. The mean accident rate of each institute was 0.7/100,000 examinations, which was widely distributed (0-25.6/100,000) depending on the institute. In this survey, relatively small institutes with less than 500 beds tend to have these accidents more frequently (p<0.01). The institutes in which daily MR examination counts are more than 10 patients have fewer accidents than those with less than 10 daily examinations. The institutes with 6-10 MR examinations daily have significantly more accidents than that with more than 10 daily MR examinations (p<0.01). The main mental factors of the accidents were considered to be "prejudice" and "carelessness" but some advocate "ignorance." Though we could not find significant reduction in the institutes that have lectures and training for MR safety, we should continue lectures and training for MR safety to reduce accidents due to "ignorance."

  3. Highway accident involving radiopharmaceuticals near Brookhaven, Mississippi on December 3, 1983

    SciTech Connect

    Mohr, P.B.; Mount, M.E.; Schwartz, M.W.

    1985-04-01

    A rear-end collision occurred between a passenger automobile and a luggage trailer carrying 84 packages, 76 of which contained radiopharmaceuticals, on US Highway 84 near Brookhaven, Mississippi on the afternoon of December 3, 1983. The purpose of this report is to document the mechanical circumstances of the accident, confirm the nature and quantity of radioactive materials involved, and assess the nature of the physical environment to which the packages were exposed and the response of the packages. The report consists of three major sections. The first deals wth the nature and circumstances of the accident and findings of fact. The second gives an accounting and description of the materials involved and the consequences of their exposure. The third gives an assessment and analysis of the mechanisms of damage and the conclusions which may be drawn from the investigation. 4 refs., 24 figs., 4 tabs.

  4. Statistical aspects of carbon fiber risk assessment modeling. [fire accidents involving aircraft

    NASA Technical Reports Server (NTRS)

    Gross, D.; Miller, D. R.; Soland, R. M.

    1980-01-01

    The probabilistic and statistical aspects of the carbon fiber risk assessment modeling of fire accidents involving commercial aircraft are examined. Three major sources of uncertainty in the modeling effort are identified. These are: (1) imprecise knowledge in establishing the model; (2) parameter estimation; and (3)Monte Carlo sampling error. All three sources of uncertainty are treated and statistical procedures are utilized and/or developed to control them wherever possible.

  5. Root causes and impacts of severe accidents at large nuclear power plants.

    PubMed

    Högberg, Lars

    2013-04-01

    The root causes and impacts of three severe accidents at large civilian nuclear power plants are reviewed: the Three Mile Island accident in 1979, the Chernobyl accident in 1986, and the Fukushima Daiichi accident in 2011. Impacts include health effects, evacuation of contaminated areas as well as cost estimates and impacts on energy policies and nuclear safety work in various countries. It is concluded that essential objectives for reactor safety work must be: (1) to prevent accidents from developing into severe core damage, even if they are initiated by very unlikely natural or man-made events, and, recognizing that accidents with severe core damage may nevertheless occur; (2) to prevent large-scale and long-lived ground contamination by limiting releases of radioactive nuclides such as cesium to less than about 100 TBq. To achieve these objectives the importance of maintaining high global standards of safety management and safety culture cannot be emphasized enough. All three severe accidents discussed in this paper had their root causes in system deficiencies indicative of poor safety management and poor safety culture in both the nuclear industry and government authorities.

  6. Root causes and impacts of severe accidents at large nuclear power plants.

    PubMed

    Högberg, Lars

    2013-04-01

    The root causes and impacts of three severe accidents at large civilian nuclear power plants are reviewed: the Three Mile Island accident in 1979, the Chernobyl accident in 1986, and the Fukushima Daiichi accident in 2011. Impacts include health effects, evacuation of contaminated areas as well as cost estimates and impacts on energy policies and nuclear safety work in various countries. It is concluded that essential objectives for reactor safety work must be: (1) to prevent accidents from developing into severe core damage, even if they are initiated by very unlikely natural or man-made events, and, recognizing that accidents with severe core damage may nevertheless occur; (2) to prevent large-scale and long-lived ground contamination by limiting releases of radioactive nuclides such as cesium to less than about 100 TBq. To achieve these objectives the importance of maintaining high global standards of safety management and safety culture cannot be emphasized enough. All three severe accidents discussed in this paper had their root causes in system deficiencies indicative of poor safety management and poor safety culture in both the nuclear industry and government authorities. PMID:23423737

  7. Factors affecting the probability of bus drivers being at-fault in bus-involved accidents.

    PubMed

    Goh, Kelvin; Currie, Graham; Sarvi, Majid; Logan, David

    2014-05-01

    Previous research has provided little insight into factors that influence the probability of bus drivers being at-fault in bus-involved accidents. In this study, an analysis was conducted on accident data compiled by a bus company that include an assessment on whether the bus driver was deemed by the company to hold primary responsibility for accident occurrence. Using a mixed logit modelling approach, roadway/environmental, vehicle and driver related variables that were identified to be influential were road type, speed limit, traffic/lighting conditions, bus priority, bus age/length and driver's age/gender/experience/historic at-fault accident record. Results were indicative of possible confined road-space issues that bus drivers face along routes with roadside traffic friction and point to the provision of exclusive right of way for buses as a possible way to address this. Results also suggest benefits in assigning routes comprising mainly divided roads as well as newer and shorter buses to less experienced drivers.

  8. Vulnerable Children; Three Studies of Children in Conflict: Accident Involved Children, Sexually Assualted Children and Children with Asthma.

    ERIC Educational Resources Information Center

    Burton, Lindy

    Three retrospective studies related children's socially inappropriate behavior to needs for approval and self assurance. Four girls and 16 boys (a sex difference of p=.006) involved in road accidents, aged 5 to 15, who were consecutively admitted to a hospital for arm and leg fractures were matched with controls. The accident children shared a…

  9. Accidents involving motorcyclists and cyclists in the municipality of São Paulo: characterization and trends☆☆☆

    PubMed Central

    Rodrigues, Cintia Leci; de Eston Armond, Jane; Gorios, Carlos; Souza, Patricia Colombo

    2014-01-01

    Objective To describe the characteristics of motorcycle and bicycle accident victims, according to notifications of suspected and confirmed accidents that have occurred in the municipality of São Paulo. Method This was a descriptive epidemiological study. It covered all accidents (12,924) that occurred involving motorcycles (11,366) and bicycles (1558) between January 2011 and October 2013. Data in the Health Department's information system for surveillance of violence and accidents (SIVVA) was surveyed. Results Motorcycle accidents accounted for 52.1% of the cases notified and bicycles, 7.1%. Males predominated in both types of accidents: 81.6% and 80.6%, respectively. In the motorcycle accidents, the predominant age group among the victims was from 20 to 24 years. Both types of accidents occurred during the daytime (7:00–18:00 h): 37.4% and 27.0% respectively. Among the motorcycle accidents, the driver had been using alcohol in 3% and it was not possible to identify whether this had occurred in 67%. Conclusions Public policies prioritizing financial and human resources applied toward reducing these types of accidents need to be brought in. PMID:26229868

  10. Impact of spatial kinetics in severe accident analysis for a large HWR

    SciTech Connect

    Morris, E.E.

    1994-03-01

    The impact on spatial kinetics on the analysis of severe accidents initiated by the unprotected withdrawal of one or more control rods is investigated for a large heavy water reactor. Large inter- and intra-assembly power shifts are observed, and the importance of detailed geometrical modeling of fuel assemblies is demonstrated. Neglect of space-time effects is shown to lead to erroneous estimates of safety margins, and of accident consequences in the event safety margins are exceeded. The results and conclusions are typical of what would be expected for any large, loosely coupled core.

  11. 25 CFR 170.904 - Who responds to an accident involving a radioactive or hazardous materials shipment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Hazardous and Nuclear Waste Transportation § 170.904 Who responds to an accident involving a radioactive or hazardous... Radiological Assistance Program team that may include nuclear engineers, health physicists,...

  12. 25 CFR 170.904 - Who responds to an accident involving a radioactive or hazardous materials shipment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Hazardous and Nuclear Waste Transportation § 170.904 Who responds to an accident involving a radioactive or hazardous... Radiological Assistance Program team that may include nuclear engineers, health physicists,...

  13. 25 CFR 170.904 - Who responds to an accident involving a radioactive or hazardous materials shipment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Hazardous and Nuclear Waste Transportation § 170.904 Who responds to an accident involving a radioactive or hazardous... Radiological Assistance Program team that may include nuclear engineers, health physicists,...

  14. 25 CFR 170.904 - Who responds to an accident involving a radioactive or hazardous materials shipment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Hazardous and Nuclear Waste Transportation § 170.904 Who responds to an accident involving a radioactive or hazardous... Radiological Assistance Program team that may include nuclear engineers, health physicists,...

  15. 25 CFR 170.904 - Who responds to an accident involving a radioactive or hazardous materials shipment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Miscellaneous Provisions Hazardous and Nuclear Waste Transportation § 170.904 Who responds to an accident involving a radioactive or hazardous... Radiological Assistance Program team that may include nuclear engineers, health physicists,...

  16. Report on a workshop on transportation-accident scenarios involving spent fuel

    SciTech Connect

    Wilmot, E L; McClure, J D; Luna, R E

    1981-02-01

    Much confusion and skepticism resulted from the scenarios for transportation accidents involving spent fuel that have been presented in environmental impact statements because the supporting assumptions and conclusions from the scenarios did not always appear to be consistent. As a result, the Transportation Technology Center gathered a group whose participants were experts in disciplines related to the transport of spent fuel to consider the scenarios. The group made a number of recommendations about scenario development and about areas in need of further study. This report documents the discussions held and the recommendations and conclusions of the group.

  17. Development of a Gravid Uterus Model for the Study of Road Accidents Involving Pregnant Women.

    PubMed

    Auriault, F; Thollon, L; Behr, M

    2016-01-01

    Car accident simulations involving pregnant women are well documented in the literature and suggest that intra-uterine pressure could be responsible for the phenomenon of placental abruption, underlining the need for a realistic amniotic fluid model, including fluid-structure interactions (FSI). This study reports the development and validation of an amniotic fluid model using an Arbitrary Lagrangian Eulerian formulation in the LS-DYNA environment. Dedicated to the study of the mechanisms responsible for fetal injuries resulting from road accidents, the fluid model was validated using dynamic loading tests. Drop tests were performed on a deformable water-filled container at acceleration levels that would be experienced in a gravid uterus during a frontal car collision at 25 kph. During the test device braking phase, container deformation induced by inertial effects and FSI was recorded by kinematic analysis. These tests were then simulated in the LS-DYNA environment to validate a fluid model under dynamic loading, based on the container deformations. Finally, the coupling between the amniotic fluid model and an existing finite-element full-body pregnant woman model was validated in terms of pressure. To do so, experimental test results performed on four postmortem human surrogates (PMHS) (in which a physical gravid uterus model was inserted) were used. The experimental intra-uterine pressure from these tests was compared to intra uterine pressure from a numerical simulation performed under the same loading conditions. Both free fall numerical and experimental responses appear strongly correlated. The relationship between the amniotic fluid model and pregnant woman model provide intra-uterine pressure values correlated with the experimental test responses. The use of an Arbitrary Lagrangian Eulerian formulation allows the analysis of FSI between the amniotic fluid and the gravid uterus during a road accident involving pregnant women. PMID:26592419

  18. Development of a Gravid Uterus Model for the Study of Road Accidents Involving Pregnant Women.

    PubMed

    Auriault, F; Thollon, L; Behr, M

    2016-01-01

    Car accident simulations involving pregnant women are well documented in the literature and suggest that intra-uterine pressure could be responsible for the phenomenon of placental abruption, underlining the need for a realistic amniotic fluid model, including fluid-structure interactions (FSI). This study reports the development and validation of an amniotic fluid model using an Arbitrary Lagrangian Eulerian formulation in the LS-DYNA environment. Dedicated to the study of the mechanisms responsible for fetal injuries resulting from road accidents, the fluid model was validated using dynamic loading tests. Drop tests were performed on a deformable water-filled container at acceleration levels that would be experienced in a gravid uterus during a frontal car collision at 25 kph. During the test device braking phase, container deformation induced by inertial effects and FSI was recorded by kinematic analysis. These tests were then simulated in the LS-DYNA environment to validate a fluid model under dynamic loading, based on the container deformations. Finally, the coupling between the amniotic fluid model and an existing finite-element full-body pregnant woman model was validated in terms of pressure. To do so, experimental test results performed on four postmortem human surrogates (PMHS) (in which a physical gravid uterus model was inserted) were used. The experimental intra-uterine pressure from these tests was compared to intra uterine pressure from a numerical simulation performed under the same loading conditions. Both free fall numerical and experimental responses appear strongly correlated. The relationship between the amniotic fluid model and pregnant woman model provide intra-uterine pressure values correlated with the experimental test responses. The use of an Arbitrary Lagrangian Eulerian formulation allows the analysis of FSI between the amniotic fluid and the gravid uterus during a road accident involving pregnant women.

  19. 48 CFR 252.228-7005 - Accident reporting and investigation involving aircraft, missiles, and space launch vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... investigation involving aircraft, missiles, and space launch vehicles. 252.228-7005 Section 252.228-7005 Federal... investigation involving aircraft, missiles, and space launch vehicles. As prescribed in 228.370(d), use the following clause: Accident Reporting and Investigation Involving Aircraft, Missiles, and Space...

  20. Analysis of injuries among pilots involved in fatal general aviation airplane accidents.

    PubMed

    Wiegmann, Douglas A; Taneja, Narinder

    2003-07-01

    The purpose of this study was to analyze patterns of injuries sustained by pilots involved in fatal general aviation (GA) airplane accidents. Detailed information on the pattern and nature of injuries was retrieved from the Federal Aviation Administration's autopsy database for pilots involved in fatal GA airplane accidents from 1996 to 1999. A review of 559 autopsies revealed that blunt trauma was the primary cause of death in 86.0% (N=481) of the autopsies. The most commonly occurring bony injuries were fracture of the ribs (72.3%), skull (55.1%), facial bones (49.4%), tibia (37.9%) and pelvis (36.0%). Common organ injuries included laceration of the liver (48.1%), lung (37.6%) heart (35.6%), and spleen (30.1%), and hemorrhage of the brain (33.3%) and lung (32.9%). A fractured larynx was observed in 14.7% of the cases, a finding that has not been reported in literature until now. It was observed that individuals who sustained brain hemorrhage were also more likely to have fractures of the facial bones rather than skull fractures. PMID:12729820

  1. Accident Sequence Precursor Program Large Early Release Frequency Model Development

    SciTech Connect

    Brown, T.D.; Brownson, D.A.; Duran, F.A.; Gregory, J.J.; Rodrick, E.G.

    1999-01-04

    The objectives for the ASP large early release frequency (LERF) model development work is to build a Level 2 containment response model that would capture all of the events necessary to define LERF as outlined in Regulatory Guide 1.174, can be directly interfaced with the existing Level 1 models, is technically correct, can be readily modified to incorporate new information or to represent another plant, and can be executed in SAPHIRE. The ASP LERF models being developed will meet these objectives while providing the NRC with the capability to independently assess the risk impact of plant-specific changes proposed by the utilities that change the nuclear power plants' licensing basis. Together with the ASP Level 1 models, the ASP LERF models provide the NRC with the capability of performing equipment and event assessments to determine their impact on a plant's LERF for internal events during power operation. In addition, the ASP LERF models are capable of being updated to reflect changes in information regarding the system operations and phenomenological events, and of being updated to assess the potential for early fatalities for each LERF sequence. As the ASP Level 1 models evolve to include more analysis capabilities, the LERF models will also be refined to reflect the appropriate level of detail needed to demonstrate the new capabilities. An approach was formulated for the development of detailed LERF models using the NUREG-1150 APET models as a guide. The modifications to the SAPHIRE computer code have allowed the development of these detailed models and the ability to analyze these models in a reasonable time. Ten reference LERF plant models, including six PWR models and four BWR models, which cover a wide variety of containment and nuclear steam supply systems designs, will be complete in 1999. These reference models will be used as the starting point for developing the LERF models for the remaining nuclear power plants.

  2. A visual warning system to reduce struck-by or pinning accidents involving mobile mining equipment

    PubMed Central

    Sammarco, J.; Gallagher, S.; Mayton, A.; Srednicki, J.

    2015-01-01

    This paper describes an experiment to examine whether a visual warning system can improve detection of moving machine hazards that could result in struck-by or pinning accidents. Thirty-six participants, twelve each in one of three age groups, participated in the study. A visual warning system capable of providing four different modes of warning was installed on a continuous mining machine that is used to mine coal. The speed of detecting various machine movements was recorded with and without the visual warning system. The average speed of detection for forward and reverse machine movements was reduced by 75% when using the flashing mode of the visual warning system. This translated to 0.485 m of machine travel for the fast speed condition of 19.8 m/min, which is significant in the context of the confined spaces of a mine. There were no statistically significant differences among age groups in the ability to detect machine movements for the visual warning modes in this study. The visual warning system shows promise as a safety intervention for reducing struck-by or pinning accidents involving continuous mining machines. The methods and results of this study could be applied to other moving machinery used in mining or other industries where moving machinery poses struck-by or pinning hazards. PMID:22503737

  3. Assessing injury severity in bicyclists involved in traffic accidents to more effectively prevent fatal bicycle injuries in Japan.

    PubMed

    Gomei, Sayaka; Hitosugi, Masahito; Ikegami, Keiichi; Tokudome, Shogo

    2013-10-01

    The objective of this study was to clarify the relationship between injury severity in bicyclists involved in traffic accidents and patient outcome or type of vehicle involved in order to propose effective measures to prevent fatal bicycle injuries. Hospital records were reviewed for all patients from 2007 to 2010 who had been involved in a traffic accident while riding a bicycle and were subsequently transferred to the Shock Trauma Center of Dokkyo Medical University Koshigaya Hospital. Patient outcomes and type of vehicle that caused the injury were examined. The mechanism of injury, Abbreviated Injury Scale (AIS) score, and Injury Severity Score (ISS) of the patient were determined. A total of 115 patients' records were reviewed. The mean patient age was 47.1 ± 27.4 years. The average ISS was 23.9, with an average maximum AIS (MAIS) score of 3.7. The ISS, MAIS score, head AIS score, and chest AIS score were well correlated with patient outcome. The head AIS score was significantly higher in patients who had died (mean of 4.4); however, the ISS, MAIS score, and head AIS score did not differ significantly according to the type of vehicle involved in the accident. The mean head AIS scores were as high as 2.4 or more for accidents involving any type of vehicle. This study provides useful information for forensic pathologists who suspect head injuries in bicyclists involved in traffic accidents. To effectively reduce bicyclist fatalities from traffic accidents, helmet use should be required for all bicyclists.

  4. Airborne mercury pollution from a large oil spill accident on the west coast of Korea.

    PubMed

    Pandey, Sudhir Kumar; Kim, Ki-Hyun; Yim, Un-Hyuk; Jung, Myung-Chae; Kang, Chang-Hee

    2009-05-15

    Atmospheric mercury pollution was recognized after a large oil spill on the west coast of Korea on 7 December 2007. In this study, the concentrations of gaseous elemental mercury (GEM: Hg(0)) in air were measured both shortly after the oil spill ( approximately 100h) and 1month after the accident near the accident site. When the Hg concentration levels were compared between two seashore sites and two parallel sites offshore, the values tend to decrease further offshore. The unusual rise in Hg concentration levels observed on the seashore area shortly after the accident (mean of 16.4+/-9.85ngm(-3)) dropped dramatically after 1month with active cleanup activities (2.99+/-1.40ngm(-3)). Because of the connection between crude oil and Hg (one of the major impurities), the unusual rise in the atmospheric Hg after the oil spill can be explained by the active evasion of Hg from the spilled crude oil. Although Hg levels determined a few days after the accident did not exceed the reference exposure limits (REL) proposed by several agencies, the early build-up of elemental mercury level due to the oil spill might have exerted certain impacts on the surrounding environments.

  5. [Prevention of road accidents involving non-motorized traffic participants (pedestrians and cyclists) in Germany].

    PubMed

    Zwipp, H; Ernstberger, A; Groschupf, V; Günther, K P; Haase, M; Haasper, C; Hagemeister, C; Hannawald, L; Juhra, C; Leser, H; Lob, G; Maier, R; Seeck, A; Winkler, R; Otte, D

    2012-06-01

    During a 1-day workshop organized by the German Society of Orthopaedics and Traumatology (DGOU) 15 German accident researchers used different approaches to improve the effectiveness of accident prevention for pedestrians and bicyclists on German roads. The main results of this analysis show: Fatal injuries of pedestrians have been significantly reduced by 82% between 1970 (n=6.056) and 2007 (n=695). Similarly, fatalities of bicyclists have been reduced during the same time period from 1,835 to 425 which amount to almost 80%. However, the total number of injured cyclists increased almost twice, i.e. from 40,531 (in 1979) to 78,579 (in 2007) a fact that needs to be analyzed in more detail. Although scientifically proven to provide protection against severe head injuries, helmets are worn less frequently by adolescents and women as compared to younger children and men. Fatalities of bicyclists might be reduced by using Dobli mirrors which allow the truck driver to see the bicyclist when turning right. Recently developed sensors are able to detect pedestrians walking closely (<2.5 m) and warn the truck driver acoustically. Bicycle lanes should be planned for one direction only, separated from the pedestrian way and large enough (2.0 m are safer than 1.6 m). Traffic education for school beginners and younger children should be repeated to be effective. Training for elderly bicyclists in cities with heavy traffic would also be reasonable. Active security systems in cars like ESP (electronic stability program), BAS (brake assist system), special light systems for curves, and night vision utilities are most effective to prevent collision with pedestrians and bicyclists. TV spots for bicyclists could help to point out dangerous situations and the proven benefits of wearing a helmet in the same way as previous campaigns, e.g."The 7th Sense" for car drivers. PMID:22159502

  6. 48 CFR 252.228-7005 - Accident reporting and investigation involving aircraft, missiles, and space launch vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Accident reporting and investigation involving aircraft, missiles, and space launch vehicles. 252.228-7005 Section 252.228-7005 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS...

  7. 48 CFR 252.228-7005 - Accident reporting and investigation involving aircraft, missiles, and space launch vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Accident reporting and investigation involving aircraft, missiles, and space launch vehicles. 252.228-7005 Section 252.228-7005 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS...

  8. 48 CFR 252.228-7005 - Accident reporting and investigation involving aircraft, missiles, and space launch vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Accident reporting and investigation involving aircraft, missiles, and space launch vehicles. 252.228-7005 Section 252.228-7005 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS...

  9. 48 CFR 252.228-7005 - Accident reporting and investigation involving aircraft, missiles, and space launch vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Accident reporting and investigation involving aircraft, missiles, and space launch vehicles. 252.228-7005 Section 252.228-7005 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS...

  10. [Accidents involving children and adolescents: from epidemiological findings to preventive action].

    PubMed

    Manciaux, M; Jeanneret, O

    1983-01-01

    It is generally accepted that improving epidemiological knowledge of accidents in childhood and adolescence leads to a better implementation of more efficient prevention programs. Nevertheless, it is not yet generally admitted that any new preventive measure addressing these accidents has to be evaluated by competent epidemiologists. Obviously, there are exceptions regarding these two rules. Four examples of successful implementation are presented in this paper: safety packaging of aspirin; fences around private swimming pools; changes in minimal drinking and driving age in adolescence; bicycle accidents. The discussion is focused on four intervention levels suggested for the epidemiologists. PMID:6669771

  11. Sustained improvement of attitudes about epilepsy following a reduction in media coverage of car accidents involving persons with epilepsy.

    PubMed

    Okumura, Akihisa; Nakazawa, Mika; Abe, Shinpei; Ikeno, Mitsuru; Igarashi, Ayuko; Shimizu, Toshiaki

    2015-07-01

    To evaluate changes in the attitudes of nonmedical students about epilepsy, the present study compared the results of a questionnaire that was completed in three different time periods: before media coverage of car accidents associated with epilepsy, during a period of abundant media coverage about epilepsy-related accidents, and after media coverage of epilepsy-related accidents. The nonmedical students who completed the questionnaire were divided into three groups: Years 08-10 (preaccident era), Years 11-12 (media coverage era), and Years 13-14 (postmedia coverage era). The rates of students who had read or heard about epilepsy and of students who did not think that epilepsy was a mental disorder increased annually throughout the study period. There was an improvement in attitudes about epilepsy after the media coverage era, and this change was not altered even after a decrease in the media coverage of epilepsy-related car accidents. Additionally, the rate of positive answers did not differ between Years 11-12 and Years 13-14. These findings demonstrate that the familiarity with and improved attitudes about epilepsy were sustained even after the media coverage of car accidents involving persons with epilepsy had decreased.

  12. The Implications of Handling Qualities in Civil Helicopter Accidents Involving Hover and Low Speed Flight

    NASA Technical Reports Server (NTRS)

    Dugan, Daniel C.; Delamer, Kevin J.

    2005-01-01

    Because of increasing accident rates in Army helicopters in hover and low speed flight, a study was made in 1999 of accidents which could be attributed to inadequate stability augmentation. A study of civil helicopter accidents from 1993-2004 was then undertaken to pursue the issue of poor handling qualities in helicopters which, in almost all cases, had no stability augmentation. The vast majority of the mishaps studied occurred during daylight in visual meteorological condition, reducing the impact of degraded visual environments (DVE) on the results. Based on the Cooper-Harper Rating Scale, the handling qualities of many of the helicopters studied could be described as having from "very objectionable" to "major" deficiencies. These costly deficiencies have resulted in unnecessary loss of life, injury, and high dollar damage. Low cost and lightweight augmentation systems for helicopters have been developed in the past and are still being investigated. They offer the potential for significant reductions in the accident rate.

  13. [Role of collision velocity in traffic accidents involving automobiles and pedestrians].

    PubMed

    Varga, T; Horváth, J

    1990-01-01

    On the basis of facts of the investigation and medical as well as technical experts' opinion on traffic accidents that happened between cars and pedestrians in Budapest in 1986, the authors studied the role of the travelling speed and collision speed in the severity of injuries suffered. They concluded that a 20% reduction of the 60 km per hour speed limit currently valid in inhabited areas in Hungary, i.e. compliance with the European standard, would reduce the number of fatal traffic accidents by as much as 40%, and the mean severity score of injuries suffered would decrease from ISS 26.90 to ISS 19.96. PMID:2241820

  14. A Statistical Description of the Types and Severities of Accidents Involving Tractor Semi-Trailers, Updated Results for 1992-1996

    SciTech Connect

    BLOWER,DANIEL F.; CLAUSS,DAVID B.

    1999-10-01

    This report provides a statistical description of the types and severities of tractor semi-trailer accidents involving at least one fatality. The data were developed for use in risk assessments of hazardous materials transportation. A previous study (SAND93-2580) reviewed the availability of accident data, identified the TIFA (Trucks Involved in Fatal Accidents) as the best source of accident data for accidents involving heavy trucks, and provided statistics on accident data collected between 1980 and 1990. The current study is an extension of the previous work and describes data collected for heavy truck accidents occurring between 1992 and 1996. The TIFA database created at the University of Michigan Transportation Research Institute was extensively utilized. Supplementary data on collision and fire severity, which was not available in the TIFA database, were obtained by reviewing police reports and interviewing responders and witnesses for selected TEA accidents. The results are described in terms of frequencies of different accident types and cumulative distribution functions for the peak contact velocity, rollover skid distance, effective fire temperature, fire size, fire separation, and fire duration.

  15. TRANSIENT ACCIDENT ANALYSIS OF THE GLOVEBOX SYSTEM IN A LARGE PROCESS ROOM

    SciTech Connect

    Lee, S

    2008-01-11

    Local transient hydrogen concentrations were evaluated inside a large process room when the hydrogen gas was released by three postulated accident scenarios associated with the process tank leakage and fire leading to a loss of gas confinement. The three cases considered in this work were fire in a room, loss of confinement from a process tank, and loss of confinement coupled with fire event. Based on these accident scenarios in a large and unventilated process room, the modeling calculations of the hydrogen migration were performed to estimate local transient concentrations of hydrogen due to the sudden leakage and release from a glovebox system associated with the process tank. The modeling domain represented the major features of the process room including the principal release or leakage source of gas storage system. The model was benchmarked against the literature results for key phenomena such as natural convection, turbulent behavior, gas mixing due to jet entrainment, and radiation cooling because these phenomena are closely related to the gas driving mechanisms within a large air space of the process room. The modeling results showed that at the corner of the process room, the gas concentrations migrated by the Case 2 and Case 3 scenarios reached the set-point value of high activity alarm in about 13 seconds, while the Case 1 scenario takes about 90 seconds to reach the concentration. The modeling results were used to estimate transient radioactive gas migrations in an enclosed process room installed with high activity alarm monitor when the postulated leakage scenarios are initiated without room ventilation.

  16. Large-Break Loss-of-Coolant Accident Testing and Simulation for 200-MWe Simplified Boiling Water Reactor

    SciTech Connect

    Revankar, S.T.; Xu, Y.; Yoon, H.J.; Ishii, M.

    2002-07-01

    The performance of the safety systems of a new design of the 200-MWe simplified boiling water reactor during a large-break, loss-of-coolant accident transient was investigated through code modeling and integral system testing. The accident considered was a break in the main steam line which is the major design basis accident. RELAP5/MOD3 best estimate reactor thermalhydraulic code was used and its applicability to the reactor safety system evaluation was examined. The integral tests were performed to assess the safety systems and the response of the emergency core cooling systems to accident conditions in a scaled facility called PUMA. The details of the safety system behavior are presented. The integral test simulations examined code applicability at the scaled facility level as well as prototype key safety system performance. (authors)

  17. Large vessel involvement by IgG4-related disease

    PubMed Central

    Perugino, Cory A.; Wallace, Zachary S.; Meyersohn, Nandini; Oliveira, George; Stone, James R.; Stone, John H.

    2016-01-01

    Abstract Objectives: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs and lead to tumefactive, tissue-destructive lesions. Reports have described inflammatory aortitis and periaortitis, the latter in the setting of retroperitoneal fibrosis (RPF), but have not distinguished adequately between these 2 manifestations. The frequency, radiologic features, and response of vascular complications to B cell depletion remain poorly defined. We describe the clinical features, radiology findings, and treatment response in a cohort of 36 patients with IgG4-RD affecting large blood vessels. Methods: Clinical records of all patients diagnosed with IgG4-RD in our center were reviewed. All radiologic studies were reviewed. We distinguished between primary large blood vessel inflammation and secondary vascular involvement. Primary involvement was defined as inflammation in the blood vessel wall as a principal focus of disease. Secondary vascular involvement was defined as disease caused by the effects of adjacent inflammation on the blood vessel wall. Results: Of the 160 IgG4-RD patients in this cohort, 36 (22.5%) had large-vessel involvement. The mean age at disease onset of the patients with large-vessel IgG4-RD was 54.6 years. Twenty-eight patients (78%) were male and 8 (22%) were female. Thirteen patients (36%) had primary IgG4-related vasculitis and aortitis with aneurysm formation comprised the most common manifestation. This affected 5.6% of the entire IgG4-RD cohort and was observed in the thoracic aorta in 8 patients, the abdominal aorta in 4, and both the thoracic and abdominal aorta in 3. Three of these aneurysms were complicated by aortic dissection or contained perforation. Periaortitis secondary to RPF accounted for 27 of 29 patients (93%) of secondary vascular involvement by IgG4-RD. Only 5 patients demonstrated evidence of both primary and secondary blood vessel involvement. Of those treated with

  18. A review of suspected cases of driving under the influence of drugs (DUID) involved in traffic accidents in Istanbul (Turkey).

    PubMed

    Acar, Fatih; Asirdizer, Mahmut; Aker, Rezzan Gulhan; Kucukibrahimoglu, E Esra; Ates, Ismail; Erol, Yeter; Sahin, Aysegul

    2013-08-01

    Nowadays traffic accidents, which have high mortality and morbidity, are an important public health problem. The association between the use of alcohol and/or drugs by drivers and the increased risk of traffic accidents with a high risk of death and injury has been well described in the literature. This study aimed to review the incidence of cases of driving under the influence of drugs (DUID) among all cases of driving under the influence (DUI) of alcohol and/or other drugs involved in traffic accidents and to evaluate the type of the psychoactive drugs (with or without alcohol) detected in blood samples in Istanbul and its surrounding area. This study is the first investigation on the subject of DUID cases in Turkey. The reports of the Istanbul Toxicology Department of the Council of Forensic Medicine (Turkey) on suspected DUID cases involved in traffic accidents between 1 July 2010 and 30 June 2011 were retrospectively reviewed for alcohol and/or drug use. Alcohol analysis was requested in 4274 suspected DUI cases, whereas drug along with alcohol analysis was requested in only 91. The rate of suspected DUID cases (n = 91) among the suspected DUI cases (n = 4274) was only 2.1% and in this study, we evaluated only the DUID cases in detail. Alcohol was present in 44% of suspected DUID cases. Psychoactive drugs were present in 15.4% of cases. The incidence among 46 confirmed DUID cases was found to be 17.4% for cannabis, 8.7% for benzodiazepines, 4.3% for barbiturates, 4.3% for antidepressants, 2.2% for cocaine and 2.2% for amphetamines. Although there is a zero-tolerance approach for DUID in the Turkish regulations, it is not well recognised and not inspected by police and legal authorities who are responsible for taking measures in traffic accidents and for routine traffic controls in Turkey. It is concluded that psychoactive drugs should be checked as well as alcohol in all traffic accident cases and roadside controls. PMID:23910848

  19. Hybrid and electric low-noise cars cause an increase in traffic accidents involving vulnerable road users in urban areas.

    PubMed

    Brand, Stephan; Petri, Maximilian; Haas, Philipp; Krettek, Christian; Haasper, Carl

    2013-01-01

    Due to resource scarcity, the number of low-noise and electric cars is expected to increase rapidly. The frequent use of these cars will lead to a significant reduction of traffic related noise and pollution. On the other hand, due to the adaption and conditioning of vulnerable road users the number of traffic accidents involving pedestrians and bicyclists is postulated to increase as well. Children, older people with reduced eyesight and the blind are especially reliant on a combination of acoustic and visual warning signals with approaching or accelerating vehicles. This is even more evident in urban areas where the engine sound is the dominating sound up to 30 kph (kilometres per hour). Above this, tyre-road interaction is the main cause of traffic noise. With the missing typical engine sound a new sound design is necessary to prevent traffic accidents in urban areas. Drivers should not be able to switch the sound generator off.

  20. Hybrid and electric low-noise cars cause an increase in traffic accidents involving vulnerable road users in urban areas.

    PubMed

    Brand, Stephan; Petri, Maximilian; Haas, Philipp; Krettek, Christian; Haasper, Carl

    2013-01-01

    Due to resource scarcity, the number of low-noise and electric cars is expected to increase rapidly. The frequent use of these cars will lead to a significant reduction of traffic related noise and pollution. On the other hand, due to the adaption and conditioning of vulnerable road users the number of traffic accidents involving pedestrians and bicyclists is postulated to increase as well. Children, older people with reduced eyesight and the blind are especially reliant on a combination of acoustic and visual warning signals with approaching or accelerating vehicles. This is even more evident in urban areas where the engine sound is the dominating sound up to 30 kph (kilometres per hour). Above this, tyre-road interaction is the main cause of traffic noise. With the missing typical engine sound a new sound design is necessary to prevent traffic accidents in urban areas. Drivers should not be able to switch the sound generator off. PMID:23083396

  1. Anaplastic Large Cell Lymphoma Involving Anterior Segment of the Eye

    PubMed Central

    Park, Choul Yong; Hwang, Sang Won; Kim, Do Yeun; Huh, Hee Jin

    2014-01-01

    A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure. PMID:24505208

  2. Persons with Mild or Moderate Alzheimer's Disease Learn to Use Urine Alarms and Prompts to Avoid Large Urinary Accidents

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Bosco, Andrea; Zonno, Nadia; Badagliacca, Francesco

    2011-01-01

    This study assessed whether three patients with Alzheimer's disease could learn to use urine alarms and caregivers' prompts to eliminate large urinary accidents. As soon as the patient began to release urine, the alarm system presented auditory and vibratory signals. In relation to those signals, the caregiver would prompt/encourage the patient to…

  3. AP600 large-break loss-of-collant-accident developmental assessment plan for TRAC-PF1/MOD2

    SciTech Connect

    Knight, T.D.

    1996-07-01

    The Westinghouse AP600 reactor is an advanced pressurized water reactor with passive safety systems to protect the plant against possible accidents and transients. The design has been submitted to the U.S. NRC for design certification. The NRC has selected the Transient Reactor Analysis Code (TRAC)-PF1/MOD2 for performing large break loss-of coolant-accident (LBLOCA) analysis to support the certification effort. This document defines the tests to be used in the current phase of developmental assessment related to AP600 LBLOCA.

  4. Preservation of Involved Teeth Associated with Large Dentigerous Cysts

    PubMed Central

    Guven, Yeliz; Kasimoglu, Yelda; Soluk Tekkesin, Merva; Ulug, Dicle; Cankaya, Abdulkadir Burak; Tuna, Elif Bahar; Gencay, Koray; Aktoren, Oya

    2014-01-01

    Dentigerous cysts (DCs) are benign odontogenic cysts that are associated with the crowns of permanent teeth. The purpose of this study is to describe the management of DCs in four children. Four boys aged between 7 and 9 years were referred to our clinics with the complaints of intraoral alveolar swelling or facial asymmetry on the affected area. The panoramic radiographies showed large, well-defined radiolucent lesions associated with the deciduous teeth and displaced tooth buds. The treatment consisted of the extraction of the involved deciduous tooth and marsupialization of the cyst to allow eruption of the permanent tooth. Permanent teeth displaced by the DCs in three cases erupted spontaneously within one-year period. The case with horizontally displaced permanent tooth was managed by replantation. This is the first time that underlying permanent tooth in a DC case was intentionally replanted. PMID:27355026

  5. Results of the intercalibration study of laboratories involved in assessing the environmental consequences of the Chernobyl accident.

    PubMed

    Cooper, E L; Valkovic, V; Strachnov, V; Dekner, R; Danesi, P R

    1992-01-01

    Within the framework of the International Chernobyl Project, the IAEA's Seibersdorf Laboratories organized an intercalibration exercise among some of the laboratories which were involved in assessing the environmental contamination in the USSR due to the accident. The objective was to assess the reliability of the radioanalytical data for food and environmental samples, which were used to assess the doses. In the initial study reference materials from the stocks of the IAEA's Analytical Quality Control Services (AQCS) were re-labelled and submitted to 71 laboratories as blind samples. These natural matrix materials included samples of milk (containing 2 different levels of radioactivity), soil, air filters and clover. The concentrations of radionuclides in these samples were known from previous intercalibration exercises. The overall range in performance was broad, which is similar to what has been observed in previous international intercomparisons. The results obtained by gamma-ray spectrometry tended to be somewhat underestimated, on average. On the other hand, the laboratories showed an overall tendency to overestimate 90Sr and possibly 239Pu, which were analysed radiochemically. The intercalibration exercise is continuing with nine materials, including: soil, grass, hay and milk powder contaminated with fallout from the Chernobyl accident. These materials, which were prepared by laboratories in the USSR, are now being tested by AQCS prior to future intercomparison exercises. Work with these materials is expected to continue for several years.

  6. Accident analysis of large-scale technological disasters applied to an anaesthetic complication.

    PubMed

    Eagle, C J; Davies, J M; Reason, J

    1992-02-01

    The occurrence of serious accidents in complex industrial systems such as at Three Mile Island and Bhopal has prompted development of new models of causation and investigation of disasters. These analytical models have potential relevance in anaesthesia. We therefore applied one of the previously described systems to the investigation of an anaesthetic accident. The model chosen describes two kinds of failures, both of which must be sought. The first group, active failures, consists of mistakes made by practitioners in the provision of care. The second group, latent failures, represents flaws in the administrative and productive system. The model emphasizes the search for latent failures and shows that prevention of active failures alone is insufficient to avoid further accidents if latent failures persist unchanged. These key features and the utility of this model are illustrated by application to a case of aspiration of gastric contents. While four active failures were recognized, an equal number of latent failures also became apparent. The identification of both types of failures permitted the formulation of recommendations to avoid further occurrences. Thus this model of accident causation can provide a useful mechanism to investigate and possibly prevent anaesthetic accidents. PMID:1544192

  7. The Sheffield experiment: the effects of centralising accident and emergency services in a large urban setting

    PubMed Central

    Simpson, A; Wardrope, J; Burke, D

    2001-01-01

    Objectives—To assess the effects of centralisation of accident and emergency (A&E) services in a large urban setting. The end points were the quality of patient care judged by time to see a doctor or nurse practitioner, time to admission and the cost of the A&E service as a whole. Methods—Sheffield is a large industrial city with a population of 471 000. In 1994 Sheffield health authority took a decision to centralise a number of services including the A&E services. This study presents data collected over a three year period before, during and after the centralisation of adult A&E services from two sites to one site and the centralisation of children's A&E services to a separate site. A minor injury unit was also established along with an emergency admissions unit. The study used information from the A&E departments' computer system and routinely available financial data. Results—There has been a small decrease in the number of new patient attendances using the Sheffield A&E system. Most patients go to the correct department. The numbers of acute admissions through the adult A&E have doubled. Measures of process efficiency show some improvement in times to admission. There has been measurable deterioration in the time to be seen for minor injuries in the A&E departments. This is partly offset by the very good waiting time to be seen in the minor injuries unit. The costs of providing the service within Sheffield have increased. Conclusion—Centralisation of A&E services in Sheffield has led to concentration of the most ill patients in a single adult department and separate paediatric A&E department. Despite a greatly increased number of admissions at the adult site this change has not resulted in increased waiting times for admission because of the transfer of adequate beds to support the changes. There has however been a deterioration in the time to see a clinician, especially in the A&E departments. The waiting times at the minor injury unit are very short

  8. Functional involvement of human discs large tumor suppressor in cytokinesis

    SciTech Connect

    Unno, Kenji; Hanada, Toshihiko; Chishti, Athar H.

    2008-10-15

    Cytokinesis is the final step of cell division that completes the separation of two daughter cells. We found that the human discs large (hDlg) tumor suppressor homologue is functionally involved in cytokinesis. The guanylate kinase (GUK) domain of hDlg mediates the localization of hDlg to the midbody during cytokinesis, and over-expression of the GUK domain in U2OS and HeLa cells impaired cytokinesis. Mouse embryonic fibroblasts (MEFs) derived from dlg mutant mice contained an increased number of multinucleated cells and showed reduced proliferation in culture. A kinesin-like motor protein, GAKIN, which binds directly to the GUK domain of hDlg, exhibited a similar intracellular distribution pattern with hDlg throughout mitosis and localized to the midbody during cytokinesis. However, the targeting of hDlg and GAKIN to the midbody appeared to be independent of each other. The midbody localization of GAKIN required its functional kinesin-motor domain. Treatment of cells with the siRNA specific for hDlg and GAKIN caused formation of multinucleated cells and delayed cytokinesis. Together, these results suggest that hDlg and GAKIN play functional roles in the maintenance of midbody architecture during cytokinesis.

  9. Functional involvement of human discs large tumor suppressor in cytokinesis

    PubMed Central

    Unno, Kenji; Hanada, Toshihiko; Chishti, Athar H.

    2008-01-01

    Cytokinesis is the final step of cell division that completes the separation of two daughter cells. We found that the human discs large (hDlg) tumor suppressor homologue is functionally involved in cytokinesis. The guanylate kinase (GUK) domain of hDlg mediates the localization of hDlg to the midbody during cytokinesis, and over-expression of the GUK domain in U2OS and HeLa cells impaired cytokinesis. Mouse embryonic fibroblasts (MEFs) derived from dlg mutant mice contained an increased number of multinucleated cells and showed reduced proliferation in culture. A kinesin-like motor protein, GAKIN, which binds directly to the GUK domain of hDlg, exhibited a similar intracellular distribution pattern with hDlg throughout mitosis and localized to the midbody during cytokinesis. However, the targeting of hDlg and GAKIN to the midbody appeared to be independent of each other. The midbody localization of GAKIN required its functional kinesin-motor domain. Treatment of cells with the siRNA specific for hDlg and GAKIN caused formation of multinucleated cells and delayed cytokinesis. Together, these results suggest that hDlg and GAKIN play functional roles in the maintenance of midbody architecture during cytokinesis. PMID:18760273

  10. Large break loss of coolant severe accident sequences at the HFIR (High Flux Isotope Reactor)

    SciTech Connect

    Simpson, D.B.; Greene, S.R.

    1990-01-01

    An assessment of many potential HFIR severe accident phenomena was conducted during the HFIR design effort, and many severe accident mitigating features were designed into the plant. These evaluation typically incorporated a bounding'' or highly conservative analysis approach and employed tools and techniques representative of the state of knowledge in the mid-1960s. Recently, programs to address severe accident issues were initiated at the Oak Ridge National Laboratory (ORNL) to support the HFIR probabilistic risk assessment (PRA) and equipment qualification and accident management studies. This paper presents the results of environment condition calculations conducted to evaluate a response of HFIR's heat exchanger cell environment to a double-ended rupture of a 0.25 m diameter coolant loop downstream of the circulating pump and check valve. The confinement calculations were performed using an atmospheric fission product source for the heat exchanger cell consistent with, but more conservative than that stipulated in Regulatory Guide 1.89. The results of the calculations indicate that the heat exchanger cell atmospheric temperature peaks at 377 K 225 seconds into the transient and then begins decreasing at approximately 1.7 K per minute. 8 refs., 5 figs.

  11. Accident management information needs

    SciTech Connect

    Hanson, D.J.; Ward, L.W.; Nelson, W.R.; Meyer, O.R. )

    1990-04-01

    In support of the US Nuclear Regulatory Commission (NRC) Accident Management Research Program, a methodology has been developed for identifying the plant information needs necessary for personnel involved in the management of an accident to diagnose that an accident is in progress, select and implement strategies to prevent or mitigate the accident, and monitor the effectiveness of these strategies. This report describes the methodology and presents an application of this methodology to a Pressurized Water Reactor (PWR) with a large dry containment. A risk-important severe accident sequence for a PWR is used to examine the capability of the existing measurements to supply the necessary information. The method includes an assessment of the effects of the sequence on the measurement availability including the effects of environmental conditions. The information needs and capabilities identified using this approach are also intended to form the basis for more comprehensive information needs assessment performed during the analyses and development of specific strategies for use in accident management prevention and mitigation. 3 refs., 16 figs., 7 tabs.

  12. Investigation of large transit vehicle accidents and establishing appropriate protection for wheelchair riders.

    PubMed

    Shaw, Greg

    2008-01-01

    Securing wheelchairs and restraining wheelchair riders on buses is difficult for many wheelchair riders and transit providers. This study examined injury-producing events aboard large transit buses in general in an attempt to better understand the potential risks and required protection for wheelchair users. The study found that few injuries and fatalities occur on large transit buses. Examination of the relatively few injury-producing events advanced the understanding of these events in terms of acceleration/deceleration magnitude and direction. Low acceleration/deceleration, or low-g, events such as those involving abrupt braking or turning occur frequently and are associated with approximately half of onboard passenger injuries. Unfortunately, the actual frequency of high-g events was not determined. Most of the injurious events involved the bus rapidly decelerating because of frontal impacts with another vehicle or roadside object. Further study is needed to determine the magnitude and frequency of high-g events. This information is necessary to determine the level of protection commensurate with real-world risk necessary for wheelchair riders in the transit bus environment and may ultimately facilitate the development of easier-to-use safety systems that secure and restrain wheelchairs and their riders.

  13. A Randomised Controlled Trial to Determine the Effectiveness of an Early Psychological Intervention with Children Involved in Road Traffic Accidents

    ERIC Educational Resources Information Center

    Stallard, Paul; Velleman, Richard; Salter, Emma; Howse, Imogen; Yule, William; Taylor, Gordon

    2006-01-01

    Objective: To determine whether an early intervention using a psychological debriefing format is effective in preventing psychological distress in child road traffic accident survivors. Design: Randomised controlled trial. Setting: Accident and Emergency Department, Royal United Hospital, Bath. Subjects: 158 children aged 7-18. Follow-up…

  14. Potential health risks from postulated accidents involving the Pu-238 RTG (radioisotope thermoelectric generator) on the Ulysses solar exploration mission

    SciTech Connect

    Goldman, M. ); Nelson, R.C. ); Bollinger, L. ); Hoover, M.D. . Inhalation Toxicology Research Inst.); Templeton, W. ); Anspaugh, L. (Lawren

    1990-11-02

    Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later times after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher. 83 refs.

  15. Potential health risks from postulated accidents involving the Pu-238 RTG on the Ulysses solar exploration mission

    NASA Technical Reports Server (NTRS)

    Goldman, Marvin; Hoover, Mark D.; Nelson, Robert C.; Templeton, William; Bollinger, Lance; Anspaugh, Lynn

    1991-01-01

    Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later time after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher.

  16. Wind-drag estimation in a traffic accident involving a motor scooter and a tractor-trailer.

    PubMed

    Park, Chan-Seong; Jeon, Seung-Won; Lee, Kyu-Jung; Kim, Jun-Suk; Oh, Jae-Geun; Park, Jong-Chan; Lee, Hong-Seok; Choi, Young-Shik

    2012-07-01

    This case report describes a noncontact traffic accident involving a motor scooter and a tractor-trailer with a focus on the wind-drag effect. We used load cells to measure the drag force acting on a substantially similar motor scooter when a substantially similar tractor-trailer passes by it, taking into consideration various speeds of the tractor-trailer and distances between the two vehicles. A three-dimensional steady-state flow analysis was also performed by using the CFX program for computational fluid dynamics to examine the streamlines and the pressure distribution around the tractor-trailer at various speeds. From the experiment, for a separation distance of 1.0 m (3.28 ft) and a speed of 90 km/h (55.9 mph), the maximum resultant drag force is 124.5 N (28 lb); this constitutes a degree of force that could abruptly disrupt the stability in maneuvering by an operator who is unaware of the approaching tractor-trailer. In addition, a single equation that relates the tractor-trailer speed to the drag force that acts on the motor scooter was derived on the basis of the Reynolds number (Re) and the wind-drag coefficient (C(d)): C(d) = 1.298 × 10(-7) Re.

  17. Student projects involving novel interaction with large displays.

    PubMed

    Dias, Paulo; Sousa, Tiago; Parracho, Joao; Cardoso, Igor; Monteiro, Andre; Sousa Santos, Beatriz

    2014-01-01

    DETI-Interact is an interactive system that offers information relevant to students in the lobby of the University of Aveiro's Department of Electronics, Telecommunications and Informatics (DETI). The project started in 2009 with a master's thesis addressing interaction with public displays through Android smartphones. Since then, it has evolved considerably; it currently allows gesture interaction based on a Kinect sensor. Meanwhile, it has involved third-year students, master's students, and undergraduate students participating in a research initiation program. PMID:24808202

  18. World commercial aircraft accidents

    SciTech Connect

    Kimura, C.Y.

    1993-01-01

    This report is a compilation of all accidents world-wide involving aircraft in commercial service which resulted in the loss of the airframe or one or more fatality, or both. This information has been gathered in order to present a complete inventory of commercial aircraft accidents. Events involving military action, sabotage, terrorist bombings, hijackings, suicides, and industrial ground accidents are included within this list. Included are: accidents involving world commercial jet aircraft, world commercial turboprop aircraft, world commercial pistonprop aircraft with four or more engines and world commercial pistonprop aircraft with two or three engines from 1946 to 1992. Each accident is presented with information in the following categories: date of the accident, airline and its flight numbers, type of flight, type of aircraft, aircraft registration number, construction number/manufacturers serial number, aircraft damage, accident flight phase, accident location, number of fatalities, number of occupants, cause, remarks, or description (brief) of the accident, and finally references used. The sixth chapter presents a summary of the world commercial aircraft accidents by major aircraft class (e.g. jet, turboprop, and pistonprop) and by flight phase. The seventh chapter presents several special studies including a list of world commercial aircraft accidents for all aircraft types with 100 or more fatalities in order of decreasing number of fatalities, a list of collision accidents involving commercial aircrafts, and a list of world commercial aircraft accidents for all aircraft types involving military action, sabotage, terrorist bombings, and hijackings.

  19. Integrating engineering principles into the medico-legal investigation of a rare fatal rollover car accident involving complex dynamics.

    PubMed

    Grassi, Vincenzo M; Castagnola, Flaminia; Miscusi, Massimo; De-Giorgio, Fabio

    2016-09-01

    Rollover car accidents can be the result of forceful steering or hitting an obstacle that acts like a ramp. Mortality from this type of car accident is particularly high, especially when occupants are thrown out of the vehicle. We report a case of a 67-year-old man who died after a rollover accident that occurred when he was driving a car equipped with a glass moonroof. He was found inside his car with his safety belt correctly fastened and the roof shattered. At autopsy, a wide avulsion injury of the head was observed, which was associated with an atlanto-axial dislocation and full-thickness fracture of the cervical body and posterior facet joints of the seventh cervical vertebra. The data collected at the scene of the accident were integrated with the autopsy results to yield a forensic engineering reconstruction. This reconstruction elucidated the dynamics of the event and correctly ascribed the lesions observed at autopsy to the phases of the rollover. Afterward, an analysis of the scientific literature concerning rollover crash tests was conducted to understand why the driver sustained fatal injuries even though his seatbelt was properly fastened.

  20. Integrating engineering principles into the medico-legal investigation of a rare fatal rollover car accident involving complex dynamics.

    PubMed

    Grassi, Vincenzo M; Castagnola, Flaminia; Miscusi, Massimo; De-Giorgio, Fabio

    2016-09-01

    Rollover car accidents can be the result of forceful steering or hitting an obstacle that acts like a ramp. Mortality from this type of car accident is particularly high, especially when occupants are thrown out of the vehicle. We report a case of a 67-year-old man who died after a rollover accident that occurred when he was driving a car equipped with a glass moonroof. He was found inside his car with his safety belt correctly fastened and the roof shattered. At autopsy, a wide avulsion injury of the head was observed, which was associated with an atlanto-axial dislocation and full-thickness fracture of the cervical body and posterior facet joints of the seventh cervical vertebra. The data collected at the scene of the accident were integrated with the autopsy results to yield a forensic engineering reconstruction. This reconstruction elucidated the dynamics of the event and correctly ascribed the lesions observed at autopsy to the phases of the rollover. Afterward, an analysis of the scientific literature concerning rollover crash tests was conducted to understand why the driver sustained fatal injuries even though his seatbelt was properly fastened. PMID:27406628

  1. H. R. 3124: A bill to require the Secretary of Transportation to take actions to protect against railroad accidents involving hazardous materials, introduced in the US House of Representatives, One Hundred Second Congress, First Session, July 31, 1991

    SciTech Connect

    Not Available

    1991-01-01

    This bill was introduced into the US House of Representatives on July 31, 1991 to require the Secretary of Transportation to take actions to protect against railroad accidents involving hazardous materials. One of the main aspects of this legislation is to identify railroad routes which present the greatest danger of accidents and to find alternative routes.

  2. Hazard Prevention Regarding Occupational Accidents Involving Blue-Collar Foreign Workers: A Perspective of Taiwanese Manpower Agencies.

    PubMed

    Chang, Huan-Cheng; Wang, Mei-Chin; Liao, Hung-Chang; Cheng, Shu-Fang; Wang, Ya-Huei

    2016-01-01

    Since 1989, blue-collar foreign workers have been permitted to work in Taiwanese industries. Most blue-collar foreign workers apply for jobs in Taiwan through blue-collar foreign workers' agencies. Because blue-collar foreign workers are not familiar with the language and culture in Taiwan, in occupational accident education and hazard prevention, the agencies play an important role in the coordination and translation between employees and blue-collar foreign workers. The purpose of this study is to establish the agencies' role in the occupational accidents education and hazard prevention for blue-collar foreign workers in Taiwan. This study uses a qualitative method-grounded theory-to collect, code, and analyze the data in order to understand the agencies' role in occupational accident education and hazard prevention for blue-collar foreign workers in Taiwan. The results show that the duty of agencies in occupational accident education and hazard prevention includes selecting appropriate blue-collar foreign workers, communicating between employees and blue-collar foreign workers, collecting occupational safety and health information, assisting in the training of occupational safety and health, and helping blue-collar foreign workers adapt to their lives in Taiwan. Finally, this study suggests seven important points and discusses the implementation process necessary to improve governmental policies. The government and employees should pay attention to the education/training of occupational safety and health for blue-collar foreign workers to eliminate unsafe behavior in order to protect the lives of blue-collar foreign workers. PMID:27420085

  3. Hazard Prevention Regarding Occupational Accidents Involving Blue-Collar Foreign Workers: A Perspective of Taiwanese Manpower Agencies.

    PubMed

    Chang, Huan-Cheng; Wang, Mei-Chin; Liao, Hung-Chang; Cheng, Shu-Fang; Wang, Ya-Huei

    2016-07-13

    Since 1989, blue-collar foreign workers have been permitted to work in Taiwanese industries. Most blue-collar foreign workers apply for jobs in Taiwan through blue-collar foreign workers' agencies. Because blue-collar foreign workers are not familiar with the language and culture in Taiwan, in occupational accident education and hazard prevention, the agencies play an important role in the coordination and translation between employees and blue-collar foreign workers. The purpose of this study is to establish the agencies' role in the occupational accidents education and hazard prevention for blue-collar foreign workers in Taiwan. This study uses a qualitative method-grounded theory-to collect, code, and analyze the data in order to understand the agencies' role in occupational accident education and hazard prevention for blue-collar foreign workers in Taiwan. The results show that the duty of agencies in occupational accident education and hazard prevention includes selecting appropriate blue-collar foreign workers, communicating between employees and blue-collar foreign workers, collecting occupational safety and health information, assisting in the training of occupational safety and health, and helping blue-collar foreign workers adapt to their lives in Taiwan. Finally, this study suggests seven important points and discusses the implementation process necessary to improve governmental policies. The government and employees should pay attention to the education/training of occupational safety and health for blue-collar foreign workers to eliminate unsafe behavior in order to protect the lives of blue-collar foreign workers.

  4. Hazard Prevention Regarding Occupational Accidents Involving Blue-Collar Foreign Workers: A Perspective of Taiwanese Manpower Agencies

    PubMed Central

    Chang, Huan-Cheng; Wang, Mei-Chin; Liao, Hung-Chang; Cheng, Shu-Fang; Wang, Ya-huei

    2016-01-01

    Since 1989, blue-collar foreign workers have been permitted to work in Taiwanese industries. Most blue-collar foreign workers apply for jobs in Taiwan through blue-collar foreign workers’ agencies. Because blue-collar foreign workers are not familiar with the language and culture in Taiwan, in occupational accident education and hazard prevention, the agencies play an important role in the coordination and translation between employees and blue-collar foreign workers. The purpose of this study is to establish the agencies’ role in the occupational accidents education and hazard prevention for blue-collar foreign workers in Taiwan. This study uses a qualitative method—grounded theory—to collect, code, and analyze the data in order to understand the agencies’ role in occupational accident education and hazard prevention for blue-collar foreign workers in Taiwan. The results show that the duty of agencies in occupational accident education and hazard prevention includes selecting appropriate blue-collar foreign workers, communicating between employees and blue-collar foreign workers, collecting occupational safety and health information, assisting in the training of occupational safety and health, and helping blue-collar foreign workers adapt to their lives in Taiwan. Finally, this study suggests seven important points and discusses the implementation process necessary to improve governmental policies. The government and employees should pay attention to the education/training of occupational safety and health for blue-collar foreign workers to eliminate unsafe behavior in order to protect the lives of blue-collar foreign workers. PMID:27420085

  5. Environmental measurements during the TMI-2 accident

    SciTech Connect

    Hull, A.P.

    1988-01-01

    Although the environmental consequences of the TMI accident were relatively insignificant, it was a major test of the ability of the involved state and federal radiological agencies to make a coordinated environmental monitoring response. This was accomplished largely on an ad hoc basis under the leadership of DOE. With some fine tuning, it is the basis for today's integrated FRMAP monitoring plan, which would be put into operation should another major accident occur at a US nuclear facility.

  6. Assessment of a large break loss of coolant accident scenario requiring operator action to initiate safety injection

    SciTech Connect

    Grendys, R.C.; Nissley, M.E.; Baker, D.C.

    1996-11-01

    As part of the licensing basis for a nuclear power plant, the acceptability of the Emergency Core Cooling Systems (ECCS) following a postulated Loss-of-Coolant Accident (LOCA) as described in the Code of Federal Regulations (CFR), Title 10, Chapter 1, Part 50.46, must be verified. The LOCA analysis is performed with an acceptable ECCS Evaluation Model and results must show compliance with the 10 CFR 50.46 acceptance criteria. Westinghouse Electric Corporation performs Large and Small Break LOCA and LOCA-related analyses to support the licensing basis of various nuclear power plants and also performs evaluations against the licensing basis analyses as required. Occasionally, the need arises for the holder of an operating license of a nuclear power plant to submit a Licensee Event Report (LER) to the US Nuclear Regulatory Commission (USNRC) for any event of the type described in the Code of Federal Regulations, Title 10, Chapter 1, Part 50.73. To support the LER, a Justification for Past Operation (JPO) may be performed to assess the safety consequences and implications of the event based on previous operating conditions. This paper describes the work performed for the Large Break LOCA to assess the impact of an event discovered by Florida Power and Light and reported in LER-94-005-02. For this event, it was determined that under certain circumstances, operator action would have been required to initiate safety injection (SI), thus challenging the acceptability of the ECCS. This event was specifically addressed for the Large Break LOCA by using an advanced thermal hydraulic analysis methodology with realistic input assumptions.

  7. Establishment of new regulations for radiological protection for decontamination work involving radioactive fallout emitted by the Fukushima Daiichi APP accident.

    PubMed

    Yasui, Shojiro

    2013-01-01

    In response to the accident at the Fukushima Daiichi Atomic Power Plant (APP) on March 11, 2011, the Japanese government decided to carry out decontamination projects around the plant. For the radiological protection of the decontamination workers, the Japanese government needed to establish new regulations because the existing regulation did not fit into "existing exposure situations" in which radioactive sources were scattered and spread in a wide area around the plant. The new regulations aim to set the appropriate protection standards in accordance with the risk of the ambient dose rate, radioactivity concentration, and type of radio nucleolus resulting from the APP accident, which is equivalent to or more than the typical protection required in planned situations. To maintain practicability, the Japanese government employed a validated and simplified measurement methodology for the internal exposure, ambient dose rate, and radioactivity concentration, considering restrictions in human resources and shortages of supplies in the affected areas. The article also identifies key challenges which require further research. PMID:23915240

  8. Advanced Neutron Source Reactor (ANSR) phenomena identification and ranking (PIR) for large break loss of coolant accidents (LBLOCA)

    SciTech Connect

    Ruggles, A. E.; Cheng, L. Y.; Dimenna, R. A.; Griffith, P.; Wilson, G. E.

    1994-06-01

    A team of experts in reactor analysis conducted a phenomena identification and ranking (PIR) exercise for a large break loss-of-coolant accident (LBLOCA) in the Advanced Neutron source Reactor (ANSR). The LBLOCA transient is broken into two separate parts for the PIR exercise. The first part considers the initial depressurization of the system that follows the opening of the break. The second part of the transient includes long-term decay heat removal after the reactor is shut down and the system is depressurized. A PIR is developed for each part of the LBLOCA. The ranking results are reviewed to establish if models in the RELAP5-MOD3 thermalhydraulic code are adequate for use in ANSR LBLOCA simulations. Deficiencies in the RELAP5-MOD3 code are identified and existing data or models are recommended to improve the code for this application. Experiments were also suggested to establish models for situations judged to be beyond current knowledge. The applicability of the ANSR PIR results is reviewed for the entire set of transients important to the ANSR safety analysis.

  9. Road accidents caused by drivers falling asleep.

    PubMed

    Sagberg, F

    1999-11-01

    About 29600 Norwegian accident-involved drivers received a questionnaire about the last accident reported to their insurance company. About 9200 drivers (31%) returned the questionnaire. The questionnaire contained questions about sleep or fatigue as contributing factors to the accident. In addition, the drivers reported whether or not they had fallen asleep some time whilst driving. and what the consequences had been. Sleep or drowsiness was a contributing factor in 3.9% of all accidents, as reported by drivers who were at fault for the accident. This factor was strongly over-represented in night-time accidents (18.6%), in running-off-the-road accidents (8.3%), accidents after driving more than 150 km on one trip (8.1%), and personal injury accidents (7.3%). A logistic regression analysis showed that the following additional factors made significant and independent contributions to increasing the odds of sleep involvement in an accident: dry road, high speed limit, driving one's own car, not driving the car daily, high education, and few years of driving experience. More male than female drivers were involved in sleep-related accidents, but this seems largely to be explained by males driving relatively more than females on roads with high speed limits. A total of 10% of male drivers and 4% of females reported to have fallen asleep while driving during the last 12 months. A total of 4% of these events resulted in an accident. The most frequent consequence of falling asleep--amounting to more than 40% of the reported incidents--was crossing of the right edge-line before awaking, whereas crossing of the centreline was reported by 16%. Drivers' lack of awareness of important precursors of falling asleep--like highway hypnosis, driving without awareness, and similar phenomena--as well as a reluctance to discontinue driving despite feeling tired are pointed out as likely contributors to sleep-related accidents. More knowledge about the drivers' experiences immediately

  10. Safety Is No Accident.

    ERIC Educational Resources Information Center

    Christiansen, Monty L.

    1985-01-01

    Liability suits involving accidents in park and recreation areas are expensive and intangible costs are incalculable. Risk management practices related to park planning, personnel, and administrative practices are discussed. (MT)

  11. A Deployable In Vivo EPR Tooth Dosimeter for Triage After a Radiation Event Involving Large Populations.

    PubMed

    Williams, Benjamin B; Dong, Ruhong; Flood, Ann Barry; Grinberg, Oleg; Kmiec, Maciej; Lesniewski, Piotr N; Matthews, Thomas P; Nicolalde, Roberto J; Raynolds, Tim; Salikhov, Ildar K; Swartz, Harold M

    2011-09-01

    In order to meet the potential need for emergency large-scale retrospective radiation biodosimetry following an accident or attack, we have developed instrumentation and methodology for in vivo electron paramagnetic resonance spectroscopy to quantify concentrations of radiation-induced radicals within intact teeth. This technique has several very desirable characteristics for triage, including independence from confounding biologic factors, a non-invasive measurement procedure, the capability to make measurements at any time after the event, suitability for use by non-expert operators at the site of an event, and the ability to provide immediate estimates of individual doses. Throughout development there has been a particular focus on the need for a deployable system, including instrumental requirements for transport and field use, the need for high throughput, and use by minimally trained operators.Numerous measurements have been performed using this system in clinical and other non-laboratory settings, including in vivo measurements with unexposed populations as well as patients undergoing radiation therapies. The collection and analyses of sets of three serially-acquired spectra with independent placements of the resonator, in a data collection process lasting approximately five minutes, provides dose estimates with standard errors of prediction of approximately 1 Gy. As an example, measurements were performed on incisor teeth of subjects who had either received no irradiation or 2 Gy total body irradiation for prior bone marrow transplantation; this exercise provided a direct and challenging test of our capability to identify subjects who would be in need of acute medical care.

  12. New regulations for radiation protection for work involving radioactive fallout emitted by the TEPCO Fukushima Daiichi APP accident--disposal of contaminated soil and wastes.

    PubMed

    Yasui, Shojiro

    2014-01-01

    The accident at the Fukushima Daiichi Atomic Power Plant that accompanied the Great East Japan Earthquake on March 11, 2011, released a large amount of radioactive material. To rehabilitate the contaminated areas, the government of Japan decided to carry out decontamination work and manage the waste resulting from decontamination. In the summer of 2013, the Ministry of the Environment planned to begin a full-scale process for waste disposal of contaminated soil and wastes removed as part of the decontamination work. The existing regulations were not developed to address such a large amount of contaminated wastes. The Ministry of Health, Labour and Welfare (MHLW), therefore, had to amend the existing regulations for waste disposal workers. The amendment of the general regulation targeted the areas where the existing exposure situation overlaps the planned exposure situation. The MHLW established the demarcation lines between the two regulations to be applied in each situation. The amendment was also intended to establish provisions for the operation of waste disposal facilities that handle large amounts of contaminated materials. Deliberation concerning the regulation was conducted when the facilities were under design; hence, necessary adjustments should be made as needed during the operation of the facilities. PMID:24856781

  13. New regulations for radiation protection for work involving radioactive fallout emitted by the TEPCO Fukushima Daiichi APP accident--disposal of contaminated soil and wastes.

    PubMed

    Yasui, Shojiro

    2014-01-01

    The accident at the Fukushima Daiichi Atomic Power Plant that accompanied the Great East Japan Earthquake on March 11, 2011, released a large amount of radioactive material. To rehabilitate the contaminated areas, the government of Japan decided to carry out decontamination work and manage the waste resulting from decontamination. In the summer of 2013, the Ministry of the Environment planned to begin a full-scale process for waste disposal of contaminated soil and wastes removed as part of the decontamination work. The existing regulations were not developed to address such a large amount of contaminated wastes. The Ministry of Health, Labour and Welfare (MHLW), therefore, had to amend the existing regulations for waste disposal workers. The amendment of the general regulation targeted the areas where the existing exposure situation overlaps the planned exposure situation. The MHLW established the demarcation lines between the two regulations to be applied in each situation. The amendment was also intended to establish provisions for the operation of waste disposal facilities that handle large amounts of contaminated materials. Deliberation concerning the regulation was conducted when the facilities were under design; hence, necessary adjustments should be made as needed during the operation of the facilities.

  14. Tractor accidents in Swedish traffic.

    PubMed

    Pinzke, Stefan; Nilsson, Kerstin; Lundqvist, Peter

    2012-01-01

    The objective of this study is to reach a better understanding of accidents on Swedish roads involving tractors and to suggest ways of preventing them. In an earlier study we analyzed police-reported fatal accidents and accidents that led to physical injuries from 1992 to 2005. During each year of this period, tractors were involved in 128 traffic accidents on average, an average of 7 people were killed, 44 sustained serious injuries, and 143 sustained slight injuries. The number of fatalities in these tractor accidents was about 1.3% of all deaths in traffic accidents in Sweden. Cars were most often involved in the tractor accidents (58%) and 15% were single vehicle accidents. The mean age of the tractor driver involved was 39.8 years and young drivers (15-24 years) were overrepresented (30%). We are now increasing the data collected with the years 2006-2010 in order to study the changes in the number of accidents. Special attention will be given to the younger drivers and to single vehicle accidents. Based on the results we aim to develop suggestions for reducing road accidents, e.g. including measures for making farm vehicles more visible and improvement of the training provided at driving schools. PMID:22317543

  15. Cardiac Involvement in Non-Hodgkin Lymphoma, an Incidental Large Atrial Mass: A Case Report

    PubMed Central

    Aledavood, Seyed Amir; Emadi Torghabeh, Ali; Homaee Shandiz, Fateme; Memar, Bahram

    2015-01-01

    Introduction: Cardiac involvement as an initial presentation of malignant lymphoma has been a rare occurrence. Case Presentation: We have reported a 78 year old man with complaint of abdominal pain and vomiting. In patients preoperative evaluation for surgical management of an intra-abdominal mass, a large intracardiac mass has found incidentally during the echocardiography. Pathologic biopsy of right atrial mass that has removed by open heart surgery shown: non Hodgkin-B cell lymphoma. Bone marrow biopsy was taken and was positive for lymphomatous involvement. Conclusions: The patient has treated by CHOP chemotherapy regiment successfully and after completion of treatment, there was complete response. PMID:26634111

  16. Statistical evaluation of design-error related accidents

    SciTech Connect

    Ott, K.O.; Marchaterre, J.F.

    1980-01-01

    In a recently published paper (Campbell and Ott, 1979), a general methodology was proposed for the statistical evaluation of design-error related accidents. The evaluation aims at an estimate of the combined residual frequency of yet unknown types of accidents lurking in a certain technological system. Here, the original methodology is extended, as to apply to a variety of systems that evolves during the development of large-scale technologies. A special categorization of incidents and accidents is introduced to define the events that should be jointly analyzed. The resulting formalism is applied to the development of the nuclear power reactor technology, considering serious accidents that involve in the accident-progression a particular design inadequacy.

  17. Crash involvement of large trucks by configuration: a case-control study.

    PubMed Central

    Stein, H S; Jones, I S

    1988-01-01

    For a two-year period, large truck crashes on the interstate system in Washington State were investigated using a case-control method. For each large truck involved in a crash, three trucks were randomly selected for inspection from the traffic stream at the same time and place as the crash but one week later. The effects of truck and driver characteristics on crashes were assessed by comparing their relative frequency among the crash-involved and comparison sample trucks. Double trailer trucks were consistently overinvolved in crashes by a factor of two to three in both single and multiple vehicle crashes. Single unit trucks pulling trailers also were overinvolved. Doubles also had a higher frequency of jackknifing compared to tractor-trailers. The substantial overinvolvement of doubles in crashes was found regardless of driver age, hours of driving, cargo weight, or type of fleet. Younger drivers, long hours of driving, and operating empty trucks were also associated with higher crash involvement. PMID:3354729

  18. [Environmental, social, and roadway vulnerability in accidents involving transportation of hazardous products: a case study of the BR-101 highway between Osório and Torres in Rio Grande do Sul State, Brazil].

    PubMed

    Tinoco, Maria Auxiliadora Cannarozzo; Nodari, Christine Tessele; Pereira, Kimberllyn Rosa da Silva

    2016-01-01

    This study aimed to assess the environmental and social vulnerability and identify critical highway stretches for accidents involving transportation of hazardous products on the BR-101 highway between the cities of Osório and Torres in Rio Grande do Sul State, Brazil. The study's approach consisted of a multiple-criteria analysis combining highway safety analysis and environmental and social vulnerability analysis in the occurrence of accidents with hazardous products, plus cartographic analysis techniques. Thirty-eight kilometers of the highway showed high vulnerability, of which 8 kilometers with critical vulnerability, associated with bridges over rivers, water uptake points, a tunnel, environmental preservation areas, and an urban area. These stretches should be prioritized when developing action plans for accident mitigation and development of public policies for this highway. This proved to be an unprecedented approach when compared to existing studies and a potentially useful tool for decision-making in emergency operations. PMID:27653196

  19. New regulations for radiation protection for work involving radioactive fallout emitted by the TEPCO Fukushima Daiichi APP accident: application expansion to recovery and reconstruction work.

    PubMed

    Yasui, Shojiro

    2014-01-01

    The accident at the Fukushima Daiichi Atomic Power Plant that accompanied the Great East Japan Earthquake on March 11, 2011 released a large amount of radioactive material. To rehabilitate the contaminated areas, the government of Japan decided to carry out decontamination work. In April 2012, the Nuclear Emergency Response Headquarters (NERH) started dividing the restricted areas into three sub-areas based on the ambient dose rate. In accordance with the rearrangement of the restricted area, NERH decided to allow resumption of business activities, including manufacturing and farming, as well as operation of hospitals, welfare facilities, and shops and related subordinate tasks, such as maintenance, repair, and transportation. As a result, the government needed regulations for radiation protection for workers engaged in those activities. The issues that arose in the deliberation of the regulations were distilled into two points: 1) whether radiation protection systems established for a planned exposure situation should apply to construction and agricultural work activities in an existing exposure situation, and 2) how to simplify the regulation in accordance with the nature of the work activities. Further research and development concerning the following issues are warranted: a) the relationship between the radioactive concentrations of materials handled and the risk of internal exposure, and b) the relationship between the radioactive concentration of the soil and the surface contamination level.

  20. Large vessel vasculitis without temporal artery involvement: isolated form of giant cell arteritis?

    PubMed

    Lambert, M; Weber, A; Boland, B; De Plaen, J F; Donckier, J

    1996-03-01

    Diffuse arterial involvement in giant cell arteritis (GCA) is well recognized. By contrast, GCA clinically isolated to large vessels without cephalic, rheumatologic or systemic symptoms represents a much rarer manifestation of the disease. We report the cases of 4 elderly women presenting with a diffuse and symptomatic occlusive disease without the typical signs of temporal arteritis, in whom biological, angiographic or pathological findings were suggestive of GCA. Medium to high dose oral corticosteroids were given to the 4 patients, in combination with various revascularization procedures, allowing a fair clinical response. Large vessel arteritis should be considered in elderly women with diffuse non-atherosclerotic occlusive disease and elevated erythrocyte sedimentation rate, even if typical features of GCA are lacking. In those cases, a long-term treatment with corticosteroids is mandatory, but surgical or angioplastic revascularization is often required. PMID:8777852

  1. Fluid–structure interaction involving large deformations: 3D simulations and applications to biological systems

    PubMed Central

    Tian, Fang-Bao; Dai, Hu; Luo, Haoxiang; Doyle, James F.; Rousseau, Bernard

    2013-01-01

    Three-dimensional fluid–structure interaction (FSI) involving large deformations of flexible bodies is common in biological systems, but accurate and efficient numerical approaches for modeling such systems are still scarce. In this work, we report a successful case of combining an existing immersed-boundary flow solver with a nonlinear finite-element solid-mechanics solver specifically for three-dimensional FSI simulations. This method represents a significant enhancement from the similar methods that are previously available. Based on the Cartesian grid, the viscous incompressible flow solver can handle boundaries of large displacements with simple mesh generation. The solid-mechanics solver has separate subroutines for analyzing general three-dimensional bodies and thin-walled structures composed of frames, membranes, and plates. Both geometric nonlinearity associated with large displacements and material nonlinearity associated with large strains are incorporated in the solver. The FSI is achieved through a strong coupling and partitioned approach. We perform several validation cases, and the results may be used to expand the currently limited database of FSI benchmark study. Finally, we demonstrate the versatility of the present method by applying it to the aerodynamics of elastic wings of insects and the flow-induced vocal fold vibration. PMID:24415796

  2. Fluid-structure interaction involving large deformations: 3D simulations and applications to biological systems

    NASA Astrophysics Data System (ADS)

    Tian, Fang-Bao; Dai, Hu; Luo, Haoxiang; Doyle, James F.; Rousseau, Bernard

    2014-02-01

    Three-dimensional fluid-structure interaction (FSI) involving large deformations of flexible bodies is common in biological systems, but accurate and efficient numerical approaches for modeling such systems are still scarce. In this work, we report a successful case of combining an existing immersed-boundary flow solver with a nonlinear finite-element solid-mechanics solver specifically for three-dimensional FSI simulations. This method represents a significant enhancement from the similar methods that are previously available. Based on the Cartesian grid, the viscous incompressible flow solver can handle boundaries of large displacements with simple mesh generation. The solid-mechanics solver has separate subroutines for analyzing general three-dimensional bodies and thin-walled structures composed of frames, membranes, and plates. Both geometric nonlinearity associated with large displacements and material nonlinearity associated with large strains are incorporated in the solver. The FSI is achieved through a strong coupling and partitioned approach. We perform several validation cases, and the results may be used to expand the currently limited database of FSI benchmark study. Finally, we demonstrate the versatility of the present method by applying it to the aerodynamics of elastic wings of insects and the flow-induced vocal fold vibration.

  3. Diffuse large B-cell lymphoma involving the central nervous system.

    PubMed

    Gualco, Gabriela; Weiss, Lawrence M; Barber, Glen N; Bacchi, Carlos E

    2011-02-01

    Lymphomas involving the central nervous system are recognized increasingly in immunocompetent as well as immunosuppressed individuals, and the majority of the cases are diffuse large B-cell lymphoma (DLBCL). The aim of this study was to compare the immunophenotype, clinicopathological features, and association with Epstein-Barr virus (EBV) of DLBCL of the central nervous system (CNS) in 3 different clinical situations: primary, in immunocompetent patients; "primary," in immunosuppressed patients; and in patients with secondary involvement by systemic lymphoma. The authors reviewed the clinicopathological features, morphology, immunophenotype (according to germinal-center B-cell-like and nongerminal B-cell-like subtypes), and association with EBV in 36 cases of DLBCL of the CNS, including 25 primary cases, 5 associated with immunosuppression, and 6 cases with secondary involvement. Survival was evaluated in 15 cases of primary CNS lymphomas. Of the 36 patients, 19 were male and 18 female. Only 2 cases of lymphomas were EBV-positive; both occurred in immunosuppressed patients. Separation into germinal-center and non-germinal center subtypes by an immunohistochemistry panel showed that 68% of primary, 80% of secondary, and 83% of the cases associated with immunosuppression were of non-germinal-center subtype, respectively. Patients with non-germinal-center immunophenotype showed significantly worse survival than those with CNS lymphomas of the germinal-center subtype.

  4. Detailed deposition density maps constructed by large-scale soil sampling for gamma-ray emitting radioactive nuclides from the Fukushima Dai-ichi Nuclear Power Plant accident.

    PubMed

    Saito, Kimiaki; Tanihata, Isao; Fujiwara, Mamoru; Saito, Takashi; Shimoura, Susumu; Otsuka, Takaharu; Onda, Yuichi; Hoshi, Masaharu; Ikeuchi, Yoshihiro; Takahashi, Fumiaki; Kinouchi, Nobuyuki; Saegusa, Jun; Seki, Akiyuki; Takemiya, Hiroshi; Shibata, Tokushi

    2015-01-01

    Soil deposition density maps of gamma-ray emitting radioactive nuclides from the Fukushima Dai-ichi Nuclear Power Plant (NPP) accident were constructed on the basis of results from large-scale soil sampling. In total 10,915 soil samples were collected at 2168 locations. Gamma rays emitted from the samples were measured by Ge detectors and analyzed using a reliable unified method. The determined radioactivity was corrected to that of June 14, 2011 by considering the intrinsic decay constant of each nuclide. Finally the deposition maps were created for (134)Cs, (137)Cs, (131)I, (129m)Te and (110m)Ag. The radioactivity ratio of (134)Cs-(137)Cs was almost constant at 0.91 regardless of the locations of soil sampling. The radioactivity ratios of (131)I and (129m)Te-(137)Cs were relatively high in the regions south of the Fukushima NPP site. Effective doses for 50 y after the accident were evaluated for external and inhalation exposures due to the observed radioactive nuclides. The radiation doses from radioactive cesium were found to be much higher than those from the other radioactive nuclides. PMID:24703526

  5. Identification and Ranking of Phenomena Leading to Peak Cladding Temperatures in Boiling Water Reactors During Large Break Loss of Coolant Accident Transients

    SciTech Connect

    Ratnayake, Ruwan K.; Ergun, S.; Hochreiter, L.E.; Baratta, A.J.

    2002-07-01

    In the licensing and validation process of best estimate codes for the analysis of nuclear reactors and postulated accident scenarios, the identification and quantification of the calculational uncertainty is required. One of the most important aspects in this process is the identification and recognition of the crucial contributing phenomena to the overall code uncertainty. The establishment of Phenomena Identification and Ranking Tables (PIRT) provides a vehicle to assist in assessing the capabilities of the computer code, and to guide the uncertainty analysis of the calculated results. The process used in this work to identify the phenomena was reviewing both licensing and best estimate calculations, as well as experiments, which had been performed for BWR LOCA analyses. The initial PIRT was developed by a group of analysts and was compared to existing BWR LOCA PIRTs as well as BWR LOCA analyses. The initial PIRT was then independently reviewed by a second panel of experts for the selected ranking of phenomena, identification of phenomena which were ignored, as well as the basis and rationale for the ranking of the phenomena. The differences between the two groups were then resolved. PIRTs have been developed for BWR types 4 and 5/6 for the Large Break Loss of Coolant Accidents (LB-LOCA). The ranking and the corresponding rationale for each phenomenon is included in tables together with the assessed uncertainty of the code capability to predict the phenomena. (authors)

  6. Detailed deposition density maps constructed by large-scale soil sampling for gamma-ray emitting radioactive nuclides from the Fukushima Dai-ichi Nuclear Power Plant accident.

    PubMed

    Saito, Kimiaki; Tanihata, Isao; Fujiwara, Mamoru; Saito, Takashi; Shimoura, Susumu; Otsuka, Takaharu; Onda, Yuichi; Hoshi, Masaharu; Ikeuchi, Yoshihiro; Takahashi, Fumiaki; Kinouchi, Nobuyuki; Saegusa, Jun; Seki, Akiyuki; Takemiya, Hiroshi; Shibata, Tokushi

    2015-01-01

    Soil deposition density maps of gamma-ray emitting radioactive nuclides from the Fukushima Dai-ichi Nuclear Power Plant (NPP) accident were constructed on the basis of results from large-scale soil sampling. In total 10,915 soil samples were collected at 2168 locations. Gamma rays emitted from the samples were measured by Ge detectors and analyzed using a reliable unified method. The determined radioactivity was corrected to that of June 14, 2011 by considering the intrinsic decay constant of each nuclide. Finally the deposition maps were created for (134)Cs, (137)Cs, (131)I, (129m)Te and (110m)Ag. The radioactivity ratio of (134)Cs-(137)Cs was almost constant at 0.91 regardless of the locations of soil sampling. The radioactivity ratios of (131)I and (129m)Te-(137)Cs were relatively high in the regions south of the Fukushima NPP site. Effective doses for 50 y after the accident were evaluated for external and inhalation exposures due to the observed radioactive nuclides. The radiation doses from radioactive cesium were found to be much higher than those from the other radioactive nuclides.

  7. Aggressive/hostile personality traits and injury accidents: an eight-year prospective study of a large cohort of French employees -- the GAZEL cohort

    PubMed Central

    Nabi, Hermann; Consoli, Silla M.; Chiron, Mireille; Lafont, Sylviane; Zins, Marie; Lagarde, Emmanuel; Chastang, Jean-François

    2006-01-01

    Background Aggressiveness on the roads and/or anger behind the wheel are considered to be a major traffic safety problem in several countries. However, the psychological mechanisms of anger and/or aggression on the roads remain largely unclear. This study examines a large cohort of French employees followed over the 1994–2001 period to establish whether psychometric measures of aggression/hostility were significantly associated with an increased risk of injury accidents (I-A). Methods A total of 11 754 participants aged from 39 to 54 in 1993 were included in this study. Aggression/hostility was measured in 1993 using the French version of the Buss-Durkee Hostility Inventory (BDHI). Driving behaviors and I-A were recorded in 2001. Sociodemographic and alcohol consumption data were available from the cohort annual follow-up. The relationship between aggression/hostility scores and I-A was assessed using Negative Binomial regression models with time-dependent covariates. Results The overall BDHI scoring was not statistically predictive of subsequent I-A: adjusted rate ratios (aRR) = 1.02, 95% confidence interval (CI) 0.81–1.28 for participants with intermediate scores and 1.25, 95% CI 0.98–1.61 for those with high scores, both compared to those with low scores. The only BDHI subscales found to be associated with I-A were “irritability” (aRR = 1.33, 95% CI 1.02–1.75 for participants with high scores) and “negativism” (aRR = 1.32, 95% CI 1.01–1.71 for participants with high scores). Conclusion Overall aggression/hostility personality traits did not predict injury accidents in this large cohort of French employees, suggesting that aggressiveness on the roads and/or anger behind the wheel extends beyond the individual’s general propensity for aggression. PMID:16332284

  8. Biorhythmic Cycles and the Incidence of Industrial Accidents

    ERIC Educational Resources Information Center

    Carvey, Davis W.; Nibler, Roger G.

    1977-01-01

    The biorhythm theory of accident explanation that has been increasingly popularized in the business press was empirically examined. Municipal employees involved in work-related vehicular accidents and in on-the-job accidents provided the data. Each accident was analyzed to determine whether or not the accident occurred on a biorhythmically…

  9. Establishment of the central radiation dose registration system for decontamination work involving radioactive fallout emitted by the Fukushima Daiichi APP accident.

    PubMed

    Yasui, Shojiro

    2016-10-01

    With respect to radiation protection for decontamination efforts involving radioactive fallout emitted by the accident at the Fukushima Daiichi Atomic Power Plant, new regulations were established and obligated employers to monitor, record, and store of workers' dose records, and to check their past dose records at the time of employment. However, cumulative doses may not be properly maintained if a worker declares incorrect values for past doses. In response, with facilitation from the Ministry of Health, Labour and Welfare, primary contractors of decontamination works decided to establish a central dose registration system. There are four major issues in the design of the system to be resolved, included the following: primary contractors (a) do not have a legal responsibility to perform dose control for subcontractors, (b) do not have the right to control decontamination sites, (c) often organize joint ventures, and (d) correspond to a wide range of ambient dose rates. To resolve the issues, requirements of the system included the following: (a) centralize the operation of radiation passbooks, which records past doses and the results of medical examinations to each worker; (b) develop a database system that could register all dose data and accept inquiry from primary contractors; (c) establish a permanent data storage system for transferred records; and (d) provide graded type of services that are appropriate to the risk of radiation exposure. The system started its operation in December 2013 and provided dose distributions in April and July 2015. The average yearly dose in 2014 was 0.7 mSv, which increased by 0.2 mSv from 0.5 mSv in 2012 and 2013. However, no cumulative dose from 2012-2014 exceeded 20 mSv, which was far below than the dose limits (100 mSv/5 years and 50 mSv/year). Although current dose distributions of decontamination workers were within appropriate levels, careful monitoring of dose distribution is necessary for preserving the proper

  10. Establishment of the central radiation dose registration system for decontamination work involving radioactive fallout emitted by the Fukushima Daiichi APP accident.

    PubMed

    Yasui, Shojiro

    2016-10-01

    With respect to radiation protection for decontamination efforts involving radioactive fallout emitted by the accident at the Fukushima Daiichi Atomic Power Plant, new regulations were established and obligated employers to monitor, record, and store of workers' dose records, and to check their past dose records at the time of employment. However, cumulative doses may not be properly maintained if a worker declares incorrect values for past doses. In response, with facilitation from the Ministry of Health, Labour and Welfare, primary contractors of decontamination works decided to establish a central dose registration system. There are four major issues in the design of the system to be resolved, included the following: primary contractors (a) do not have a legal responsibility to perform dose control for subcontractors, (b) do not have the right to control decontamination sites, (c) often organize joint ventures, and (d) correspond to a wide range of ambient dose rates. To resolve the issues, requirements of the system included the following: (a) centralize the operation of radiation passbooks, which records past doses and the results of medical examinations to each worker; (b) develop a database system that could register all dose data and accept inquiry from primary contractors; (c) establish a permanent data storage system for transferred records; and (d) provide graded type of services that are appropriate to the risk of radiation exposure. The system started its operation in December 2013 and provided dose distributions in April and July 2015. The average yearly dose in 2014 was 0.7 mSv, which increased by 0.2 mSv from 0.5 mSv in 2012 and 2013. However, no cumulative dose from 2012-2014 exceeded 20 mSv, which was far below than the dose limits (100 mSv/5 years and 50 mSv/year). Although current dose distributions of decontamination workers were within appropriate levels, careful monitoring of dose distribution is necessary for preserving the proper

  11. Radiotherapy Accidents

    NASA Astrophysics Data System (ADS)

    Mckenzie, Alan

    A major benefit of a Quality Assurance system in a radiotherapy centre is that it reduces the likelihood of an accident. For over 20 years I have been the interface in the UK between the Institute of Physics and Engineering in Medicine and the media — newspapers, radio and TV — and so I have learned about radiotherapy accidents from personal experience. In some cases, these accidents did not become public and so the hospital cannot be identified. Nevertheless, lessons are still being learned.

  12. German aircraft accident statistics, 1930

    NASA Technical Reports Server (NTRS)

    Weitzmann, Ludwig

    1932-01-01

    The investigation of all serious accidents, involving technical defects in the airplane or engine, is undertaken by the D.V.L. in conjunction with the imperial traffic minister and other interested parties. All accidents not clearly explained in the reports are subsequently cleared up.

  13. 50 CFR 25.72 - Reporting of accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., but in no event later than 24 hours after the accident, by the persons involved, to the refuge manager... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Reporting of accidents. 25.72 Section 25... Reporting of accidents. Accidents involving damage to property, injury to the public or injury to...

  14. 50 CFR 25.72 - Reporting of accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., but in no event later than 24 hours after the accident, by the persons involved, to the refuge manager... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Reporting of accidents. 25.72 Section 25... Reporting of accidents. Accidents involving damage to property, injury to the public or injury to...

  15. The child accident repeater: a review.

    PubMed

    Jones, J G

    1980-04-01

    The child accident repeater is defined as one who has at least three accidents that come to medical attention within a year. The accident situation has features in common with those of the child who has a single accident through simple "bad luck", but other factors predispose him to repeated injury. In the child who has a susceptible personality, a tendency for accident repetition may be due to a breakdown in adjustment to a stressful environment. Prevention of repeat accidents should involve the usual measures considered appropriate for all children as well as an attempt to provide treatment of significant maladjustment and modification of a stressful environment.

  16. MESORAD dose assessment of the Chernobyl reactor accident

    SciTech Connect

    Ramsdell, J.V.; Hubbe, J.M.; Athey, G.F.; Davis, W.E.

    1989-12-01

    An accident involving Unit 4 of the Chernobylskaya Atomic Energy Station resulted in the release of a large amount of radioactive material to the atmosphere. This report describes the results of an assessment of the doses near the site (within 80 km) made at the Pacific Northwest Laboratory using the MESORAD Dose Assessment model. 6 refs., 10 figs., 5 tabs.

  17. 28 CFR 301.106 - Repetitious accidents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Repetitious accidents. 301.106 Section 301.106 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION General § 301.106 Repetitious accidents. If an inmate worker is involved in successive...

  18. 28 CFR 301.106 - Repetitious accidents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Repetitious accidents. 301.106 Section 301.106 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION General § 301.106 Repetitious accidents. If an inmate worker is involved in successive...

  19. A Scoping Analysis Of The Impact Of SiC Cladding On Late-Phase Accident Progression Involving Core–Concrete Interaction

    SciTech Connect

    Farmer, M. T.

    2015-11-01

    The overall objective of the current work is to carry out a scoping analysis to determine the impact of ATF on late phase accident progression; in particular, the molten core-concrete interaction portion of the sequence that occurs after the core debris fails the reactor vessel and relocates into containment. This additional study augments previous work by including kinetic effects that govern chemical reaction rates during core-concrete interaction. The specific ATF considered as part of this study is SiC-clad UO2.

  20. THREE-YEAR RETENTION OF RADIOACTIVE CAESIUM IN THE BODY OF TEPCO WORKERS INVOLVED IN THE FUKUSHIMA DAIICHI NUCLEAR POWER STATION ACCIDENT.

    PubMed

    Nakano, T; Tani, K; Kim, E; Kurihara, O; Sakai, K; Akashi, M

    2016-09-01

    Direct measurements of seven highly exposed workers at the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station accident have been performed continuously since June 2011. Caesium clearance in the monitored workers is in agreement with the biokinetic models proposed by the International Commission on Radiological Protection. After 500 d from the initial measurement, however, the caesium clearance slowed. It was thought to be unlikely that additional Cs intake had occurred after the initial intake, as activity in foods was kept low. And, the contribution from the detector over the chest was enhanced with time. This indicates that insoluble Cs particles were inhaled and a long metabolic rate showed.

  1. THREE-YEAR RETENTION OF RADIOACTIVE CAESIUM IN THE BODY OF TEPCO WORKERS INVOLVED IN THE FUKUSHIMA DAIICHI NUCLEAR POWER STATION ACCIDENT.

    PubMed

    Nakano, T; Tani, K; Kim, E; Kurihara, O; Sakai, K; Akashi, M

    2016-09-01

    Direct measurements of seven highly exposed workers at the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station accident have been performed continuously since June 2011. Caesium clearance in the monitored workers is in agreement with the biokinetic models proposed by the International Commission on Radiological Protection. After 500 d from the initial measurement, however, the caesium clearance slowed. It was thought to be unlikely that additional Cs intake had occurred after the initial intake, as activity in foods was kept low. And, the contribution from the detector over the chest was enhanced with time. This indicates that insoluble Cs particles were inhaled and a long metabolic rate showed. PMID:26979805

  2. Injuries are not accidents

    PubMed Central

    Gutiérrez, María Isabel

    2014-01-01

    Injuries are the result of an acute exposure to exhort of energy or a consequence of a deficiency in a vital element that exceeds physiological thresholds resulting threatens life. They are classified as intentional or unintentional. Injuries are considered a global health issue because they cause more than 5 million deaths per year worldwide and they are an important contributor to the burden of disease, especially affecting people of low socioeconomic status in low- and middle-income countries. A common misconception exists where injuries are thought to be the same as accidents; however, accidents are largely used as chance events, without taken in consideration that all these are preventable. This review discusses injuries and accidents in the context of road traffic and emphasizes injuries as preventable events. An understanding of the essence of injuries enables the standardization of terminology in public use and facilitates the development of a culture of prevention among all of us. PMID:25386040

  3. Risk factors and patterns of lymph node involvement in primary gastric large B-cell lymphoma: implications for target definition

    PubMed Central

    Zhang, Ximei; Wang, Peiguo; Zhao, Lujun; Yuan, Zhiyong; Wang, Ping

    2016-01-01

    Background The aim of this study was to identify the appropriate radiation volume for primary gastric diffuse large B-cell lymphoma (PG-DLBCL). Methods We retrospectively analyzed the clinical and pathological findings of 68 patients treated with total gastrectomy and D2 lymphadenectomy. Results There were 23, 14, and 29 patients with stage I, stage II, and stage IIE disease, respectively, and 30 patients had lymph node involvement. Primary tumor location, as well as the depth of invasion, was significantly associated with lymph node involvement. When the tumor was limited to the muscularis, the involved lymph nodes were found to be perigastric nodes. For tumors invading beyond the muscularis, regional lymph nodes were involved. Conclusion The optimal radiation volume for patients with PG-DLBCL is largely dependent on the primary location and depth of invasion. Larger series and longer follow-up are needed to further delineate the radiation volumes for PG-DLBCL. PMID:27536138

  4. Oranges and Peaches: Understanding Communication Accidents in the Reference Interview.

    ERIC Educational Resources Information Center

    Dewdney, Patricia; Michell, Gillian

    1996-01-01

    Librarians often have communication "accidents" with reference questions as initially presented. This article presents linguistic analysis of query categories, including: simple failures of hearing, accidents involving pronunciation or homophones, accidents where users repeat earlier misinterpretations to librarians, and accidents where users…

  5. Large Scale Identification of Genes Involved in Cell Surface Biosynthesis and Architecture in Saccharomyces Cerevisiae

    PubMed Central

    Lussier, M.; White, A. M.; Sheraton, J.; di-Paolo, T.; Treadwell, J.; Southard, S. B.; Horenstein, C. I.; Chen-Weiner, J.; Ram, AFJ.; Kapteyn, J. C.; Roemer, T. W.; Vo, D. H.; Bondoc, D. C.; Hall, J.; Wei Zhong, W.; Sdicu, A. M.; Davies, J.; Klis, F. M.; Robbins, P. W.; Bussey, H.

    1997-01-01

    The sequenced yeast genome offers a unique resource for the analysis of eukaryotic cell function and enables genome-wide screens for genes involved in cellular processes. We have identified genes involved in cell surface assembly by screening transposon-mutagenized cells for altered sensitivity to calcofluor white, followed by supplementary screens to further characterize mutant phenotypes. The mutated genes were directly retrieved from genomic DNA and then matched uniquely to a gene in the yeast genome database. Eighty-two genes with apparent perturbation of the cell surface were identified, with mutations in 65 of them displaying at least one further cell surface phenotype in addition to their modified sensitivity to calcofluor. Fifty of these genes were previously known, 17 encoded proteins whose function could be anticipated through sequence homology or previously recognized phenotypes and 15 genes had no previously known phenotype. PMID:9335584

  6. [Orofacial injuries in skateboard accidents].

    PubMed

    Frohberg, U; Bonsmann, M

    1992-04-01

    In a clinical study, 25 accidents involving injuries by a fall with a skateboard were investigated and classified in respect of epidemiology, accident mechanism and injury patterns in the facial region. Accident victims are predominantly boys between 7 and 9 years of age. A multiple trauma involving the teeth and the dental system in general and the soft parts of the face is defined as a characteristic orofacial injury pattern in skateboard accidents. The high proportion of damage to the front teeth poses problems of functional and aesthetic rehabilitation necessitating long-term treatment courses in children and adolescents. Effective prevention of facial injuries may be possible by evolving better facial protection systems and by creating areas of playgrounds where skateboarders can practise safely.

  7. Piercing tool, Transportation Accident Resistant Container (TARC)

    SciTech Connect

    Lari, P.

    1994-08-01

    Transportation Accident Resistant Containers (TARC)s are used for enhanced safety during movement of nuclear weapons. Its design features a tough stainless steel outer skin, redwood for impact mitigation and fire protection and a rugged aluminum inner container. Redwood absorbs impact energy by crushing, similar to the way foam crushes in other containers. Redwood also functions to insulate the weapon from heat and fire. When a TARC is involved in a fire, the redwood will slowly burn forming a good insulating char. The redwood can continue to smolder once the fire is out. To ensure the smolder is extinguished, water can be directed into any accident caused hole in the skin. If no hole exists, it may be necessary to create one. This document discusses tool selection, testing, and a simple but effective method of creating an access hole in the outer skin large enough to apply fire fighting techniques.

  8. Using Quality Circles to Enhance Student Involvement and Course Quality in a Large Undergraduate Food Science and Human Nutrition Course

    ERIC Educational Resources Information Center

    Schmidt, S. J.; Parmer, M. S.; Bohn, D. M.

    2005-01-01

    Large undergraduate classes are a challenge to manage, to engage, and to assess, yet such formidable classes can flourish when student participation is facilitated. One method of generating authentic student involvement is implementation of quality circles by means of a Student Feedback Committee (SFC), which is a volunteer problem-solving and…

  9. A review of criticality accidents

    SciTech Connect

    Stratton, W R; Smith, D R

    1989-03-01

    Criticality accidents and the characteristics of prompt power excursions are discussed. Forty-one accidental power transients are reviewed. In each case where available, enough detail is given to help visualize the physical situation, the cause or causes of the accident, the history and characteristics of the transient, the energy release, and the consequences, if any, to personnel and property. Excursions associated with large power reactors are not included in this study, except that some information on the major accident at the Chernobyl reactor in April 1986 is provided in the Appendix. 67 refs., 21 figs., 2 tabs.

  10. Definition Study for Space Shuttle Experiments Involving Large, Steerable Millimeter-Wave Antenna Arrays

    NASA Technical Reports Server (NTRS)

    Levis, C. A.

    1976-01-01

    The potential uses and techniques for the shuttle spacelab Millimeter Wave Large Aperture Antenna Experiment (MWLAE) are documented. Potential uses are identified: applications to radio astronomy, the sensing of atmospheric turbulence by its effect on water vapor line emissions, and the monitoring of oil spills by multifrequency radiometry. IF combining is preferable to RF combining with respect to signal to noise ratio for communications receiving antennas of the size proposed for MWLAE. A design approach using arrays of subapertures is proposed to reduce the number of phase shifters and mixers for uses which require a filled aperture. Correlation radiometry and a scheme utilizing synchronous Dicke switches and IF combining are proposed as potential solutions.

  11. Multivariate statistical analysis software technologies for astrophysical research involving large data bases

    NASA Technical Reports Server (NTRS)

    Djorgovski, Stanislav

    1992-01-01

    The existing and forthcoming data bases from NASA missions contain an abundance of information whose complexity cannot be efficiently tapped with simple statistical techniques. Powerful multivariate statistical methods already exist which can be used to harness much of the richness of these data. Automatic classification techniques have been developed to solve the problem of identifying known types of objects in multi parameter data sets, in addition to leading to the discovery of new physical phenomena and classes of objects. We propose an exploratory study and integration of promising techniques in the development of a general and modular classification/analysis system for very large data bases, which would enhance and optimize data management and the use of human research resources.

  12. Multivariate statistical analysis software technologies for astrophysical research involving large data bases

    NASA Technical Reports Server (NTRS)

    Djorgovski, George

    1993-01-01

    The existing and forthcoming data bases from NASA missions contain an abundance of information whose complexity cannot be efficiently tapped with simple statistical techniques. Powerful multivariate statistical methods already exist which can be used to harness much of the richness of these data. Automatic classification techniques have been developed to solve the problem of identifying known types of objects in multiparameter data sets, in addition to leading to the discovery of new physical phenomena and classes of objects. We propose an exploratory study and integration of promising techniques in the development of a general and modular classification/analysis system for very large data bases, which would enhance and optimize data management and the use of human research resource.

  13. The Undergraduate ALFALFA Team: A Model for Involving Undergraduates in Large Astronomy Collaborations

    NASA Astrophysics Data System (ADS)

    Craig, David W.; Koopmann, Rebecca A.; Haynes, Martha P.; Undergraduate ALFALFA Team, ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) has allowed faculty and students from a wide range of public and private colleges and especially those with small astronomy programs to learn how science is accomplished in a large collaboration while contributing to the scientific goals of a legacy radio astronomy survey. This effort has been made possible through the collaboration of the ALFALFA PIs and graduate students, Arecibo Observatory staff, and the faculty at 19 undergraduate-focussed institutions. In this talk, we will discuss how the UAT model works for the ALFALFA project and lessons learned from our efforts over the 8 years of grant funding. We will provide suggestions on how the model could be applied to other legacy projects, particularly in such areas as online collaboration and software usage by undergraduates. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005.

  14. Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules.

    PubMed

    Li, Lin; Alper, Joshua; Alexov, Emil

    2016-01-01

    Many biological phenomena involve the binding of proteins to a large object. Because the electrostatic forces that guide binding act over large distances, truncating the size of the system to facilitate computational modeling frequently yields inaccurate results. Our multiscale approach implements a computational focusing method that permits computation of large systems without truncating the electrostatic potential and achieves the high resolution required for modeling macromolecular interactions, all while keeping the computational time reasonable. We tested our approach on the motility of various kinesin motor domains. We found that electrostatics help guide kinesins as they walk: N-kinesins towards the plus-end, and C-kinesins towards the minus-end of microtubules. Our methodology enables computation in similar, large systems including protein binding to DNA, viruses, and membranes. PMID:26988596

  15. Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules

    NASA Astrophysics Data System (ADS)

    Li, Lin; Alper, Joshua; Alexov, Emil

    2016-03-01

    Many biological phenomena involve the binding of proteins to a large object. Because the electrostatic forces that guide binding act over large distances, truncating the size of the system to facilitate computational modeling frequently yields inaccurate results. Our multiscale approach implements a computational focusing method that permits computation of large systems without truncating the electrostatic potential and achieves the high resolution required for modeling macromolecular interactions, all while keeping the computational time reasonable. We tested our approach on the motility of various kinesin motor domains. We found that electrostatics help guide kinesins as they walk: N-kinesins towards the plus-end, and C-kinesins towards the minus-end of microtubules. Our methodology enables computation in similar, large systems including protein binding to DNA, viruses, and membranes.

  16. Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules

    PubMed Central

    Li, Lin; Alper, Joshua; Alexov, Emil

    2016-01-01

    Many biological phenomena involve the binding of proteins to a large object. Because the electrostatic forces that guide binding act over large distances, truncating the size of the system to facilitate computational modeling frequently yields inaccurate results. Our multiscale approach implements a computational focusing method that permits computation of large systems without truncating the electrostatic potential and achieves the high resolution required for modeling macromolecular interactions, all while keeping the computational time reasonable. We tested our approach on the motility of various kinesin motor domains. We found that electrostatics help guide kinesins as they walk: N-kinesins towards the plus-end, and C-kinesins towards the minus-end of microtubules. Our methodology enables computation in similar, large systems including protein binding to DNA, viruses, and membranes. PMID:26988596

  17. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.

    PubMed

    Campos, Alline Cristina; Moreira, Fabricio Araújo; Gomes, Felipe Villela; Del Bel, Elaine Aparecida; Guimarães, Francisco Silveira

    2012-12-01

    Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ(9)-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis. Although the pharmacological effects of CBD in different biological systems have been extensively investigated by in vitro studies, the mechanisms responsible for its therapeutic potential are still not clear. Here, we review recent in vivo studies indicating that these mechanisms are not unitary but rather depend on the behavioural response being measured. Acute anxiolytic and antidepressant-like effects seem to rely mainly on facilitation of 5-HT1A-mediated neurotransmission in key brain areas related to defensive responses, including the dorsal periaqueductal grey, bed nucleus of the stria terminalis and medial prefrontal cortex. Other effects, such as anti-compulsive, increased extinction and impaired reconsolidation of aversive memories, and facilitation of adult hippocampal neurogenesis could depend on potentiation of anandamide-mediated neurotransmission. Finally, activation of TRPV1 channels may help us to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD. Considering its safety profile and wide range of therapeutic potential, however, further studies are needed to investigate the involvement of other possible mechanisms (e.g. inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca(2+)) increase, etc.), on CBD behavioural effects. PMID:23108553

  18. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.

    PubMed

    Campos, Alline Cristina; Moreira, Fabricio Araújo; Gomes, Felipe Villela; Del Bel, Elaine Aparecida; Guimarães, Francisco Silveira

    2012-12-01

    Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ(9)-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis. Although the pharmacological effects of CBD in different biological systems have been extensively investigated by in vitro studies, the mechanisms responsible for its therapeutic potential are still not clear. Here, we review recent in vivo studies indicating that these mechanisms are not unitary but rather depend on the behavioural response being measured. Acute anxiolytic and antidepressant-like effects seem to rely mainly on facilitation of 5-HT1A-mediated neurotransmission in key brain areas related to defensive responses, including the dorsal periaqueductal grey, bed nucleus of the stria terminalis and medial prefrontal cortex. Other effects, such as anti-compulsive, increased extinction and impaired reconsolidation of aversive memories, and facilitation of adult hippocampal neurogenesis could depend on potentiation of anandamide-mediated neurotransmission. Finally, activation of TRPV1 channels may help us to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD. Considering its safety profile and wide range of therapeutic potential, however, further studies are needed to investigate the involvement of other possible mechanisms (e.g. inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca(2+)) increase, etc.), on CBD behavioural effects.

  19. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

    PubMed Central

    Campos, Alline Cristina; Moreira, Fabricio Araújo; Gomes, Felipe Villela; Del Bel, Elaine Aparecida; Guimarães, Francisco Silveira

    2012-01-01

    Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ9-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis. Although the pharmacological effects of CBD in different biological systems have been extensively investigated by in vitro studies, the mechanisms responsible for its therapeutic potential are still not clear. Here, we review recent in vivo studies indicating that these mechanisms are not unitary but rather depend on the behavioural response being measured. Acute anxiolytic and antidepressant-like effects seem to rely mainly on facilitation of 5-HT1A-mediated neurotransmission in key brain areas related to defensive responses, including the dorsal periaqueductal grey, bed nucleus of the stria terminalis and medial prefrontal cortex. Other effects, such as anti-compulsive, increased extinction and impaired reconsolidation of aversive memories, and facilitation of adult hippocampal neurogenesis could depend on potentiation of anandamide-mediated neurotransmission. Finally, activation of TRPV1 channels may help us to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD. Considering its safety profile and wide range of therapeutic potential, however, further studies are needed to investigate the involvement of other possible mechanisms (e.g. inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca2+) increase, etc.), on CBD behavioural effects. PMID:23108553

  20. Radiation accidents

    SciTech Connect

    Saenger, E.L.

    1986-09-01

    It is essential that emergency physicians understand ways to manage patients contaminated by radioactive materials and/or exposed to external radiation sources. Contamination accidents require careful surveys to identify the metabolic pathway of the radionuclides to guide prognosis and treatment. The level of treatment required will depend on careful surveys and meticulous decontamination. There is no specific therapy for the acute radiation syndrome. Prophylactic antibodies are desirable. For severely exposed patients treatment is similar to the supportive care given to patients undergoing organ transplantation. For high-dose extremity injury, no methods have been developed to reverse the fibrosing endarteritis that eventually leads to tissue death so frequently found with this type of injury. Although the Three Mile Island episode of March 1979 created tremendous public concern, there were no radiation injuries. The contamination outside the reactor building and the release of radioiodine were negligible. The accidental fuel element meltdown at Chernobyl, USSR, resulted in many cases of acute radiation syndrome. More than 100,000 people were exposed to high levels of radioactive fallout. The general principles outlined here are applicable to accidents of that degree of severity.

  1. Radiation accidents.

    PubMed

    Saenger, E L

    1986-09-01

    It is essential that emergency physicians understand ways to manage patients contaminated by radioactive materials and/or exposed to external radiation sources. Contamination accidents require careful surveys to identify the metabolic pathway of the radionuclides to guide prognosis and treatment. The level of treatment required will depend on careful surveys and meticulous decontamination. There is no specific therapy for the acute radiation syndrome. Prophylactic antibodies are desirable. For severely exposed patients treatment is similar to the supportive care given to patients undergoing organ transplantation. For high-dose extremity injury, no methods have been developed to reverse the fibrosing endarteritis that eventually leads to tissue death so frequently found with this type of injury. Although the Three Mile Island episode of March 1979 created tremendous public concern, there were no radiation injuries. The contamination outside the reactor building and the release of radioiodine were negligible. The accidental fuel element meltdown at Chernobyl, USSR, resulted in many cases of acute radiation syndrome. More than 100,000 people were exposed to high levels of radioactive fallout. The general principles outlined here are applicable to accidents of that degree of severity. PMID:3526994

  2. Project of a Large Superconductor Detector Involving Directed Diffusion of Hot Electrons and Microcalorimeter

    SciTech Connect

    Shpinel, V.S.

    2005-12-01

    In recent years, radically new detectors for soft x rays and gamma rays were developed on the basis of superconducting tunnel junctions. These detectors made it possible to attain a very high resolution, but their largest area is overly small for employing them in nuclear spectroscopy. This study is devoted to the problem of designing a superconductor detector whose dimensions are sufficiently large for detecting gamma rays and which is suitable for applications in various fields of science. The detector consists of three units: an absorber, a hot-electron calorimeter, and a tunnel-junction (normal metal-insulator-superconductor) thermometer. The absorber has a multilayer structure consisting of thin superconductor layers arranged in the order of variation of the superconductor energy gap. This structure specifies the direction of hot-electron diffusion. Since quasiparticles diffuse in a specific direction, the diffusion time becomes shorter than that in the case of conventional diffusion. It is necessary that this time be shorter than the time of electron-phonon interaction. Calculations of the diffusion time for the particular structure in question and data from the literature on electron-phonon interaction show that the operating area of the detector can be about 3 to 4 mm{sup 2} and that its thickness can be about 1 mm. These dimensions can be considerably increased in the case of especially pure superconductors.

  3. Regional contraction of brain surface area involves three large-scale networks in schizophrenia.

    PubMed

    Palaniyappan, Lena; Mallikarjun, Pavan; Joseph, Verghese; White, Thomas P; Liddle, Peter F

    2011-07-01

    In schizophrenia, morphological changes in the cerebral cortex have been primarily investigated using volumetric or cortical thickness measurements. In healthy subjects, as the brain size increases, the surface area expands disproportionately when compared to the scaling of cortical thickness. In this structural MRI study, we investigated the changes in brain surface area in schizophrenia by constructing relative areal contraction/expansion maps showing group differences in surface area using Freesurfer software in 57 patients and 41 controls. We observed relative areal contraction affecting Default Mode Network, Central Executive Network and Salience Network, in addition to other regions in schizophrenia. We confirmed the surface area reduction across these three large-scale brain networks by undertaking further region-of-interest analysis of surface area. We also observed a significant hemispheric asymmetry in the surface area changes, with the left hemisphere showing a greater reduction in the areal contraction maps. Our findings suggest that a fundamental disturbance in cortical expansion is likely in individuals who develop schizophrenia. PMID:21497489

  4. Typical accidents encountered by assembly workers: six scenarios for safety planning identified using multivariate methods.

    PubMed

    Laflamme, L; Backström, T; Döös, M

    1993-08-01

    This study highlights the most typical accidents encountered by assembly workers employed in a variety of different workshops at a large automobile and truck factory in Sweden. Following site visits and the collection of data from accident registers, statistics on 28 accident characteristics were compiled on the basis of the 145 accidents involving assemblers in 1986 and 1987. For data treatment, two statistical methods complemented one another: the factorial analysis of correspondence (FAC) and the hierarchical ascendant classification (HAC). Six typical accident profiles were extensively portrayed, quantified, and illustrated graphically: overexertion; falls and stumbling; injuries related to the handling of tools; superficial wounds to the (left) hand; cuts/pinches from moving machine parts and the handling of objects; miscellaneous blows from work pieces. The distribution of these types of accidents across the workshops was studied. It is emphasized that the search for typical accident patterns using multivariate statistical methods helps to structure and define the accident problems of a target group and therefore provides benefits for the evaluation of the need for preventive measures. PMID:8357453

  5. Multivariate statistical analysis software technologies for astrophysical research involving large data bases

    NASA Technical Reports Server (NTRS)

    Djorgovski, S. George

    1994-01-01

    We developed a package to process and analyze the data from the digital version of the Second Palomar Sky Survey. This system, called SKICAT, incorporates the latest in machine learning and expert systems software technology, in order to classify the detected objects objectively and uniformly, and facilitate handling of the enormous data sets from digital sky surveys and other sources. The system provides a powerful, integrated environment for the manipulation and scientific investigation of catalogs from virtually any source. It serves three principal functions: image catalog construction, catalog management, and catalog analysis. Through use of the GID3* Decision Tree artificial induction software, SKICAT automates the process of classifying objects within CCD and digitized plate images. To exploit these catalogs, the system also provides tools to merge them into a large, complete database which may be easily queried and modified when new data or better methods of calibrating or classifying become available. The most innovative feature of SKICAT is the facility it provides to experiment with and apply the latest in machine learning technology to the tasks of catalog construction and analysis. SKICAT provides a unique environment for implementing these tools for any number of future scientific purposes. Initial scientific verification and performance tests have been made using galaxy counts and measurements of galaxy clustering from small subsets of the survey data, and a search for very high redshift quasars. All of the tests were successful, and produced new and interesting scientific results. Attachments to this report give detailed accounts of the technical aspects for multivariate statistical analysis of small and moderate-size data sets, called STATPROG. The package was tested extensively on a number of real scientific applications, and has produced real, published results.

  6. Multivariate Statistical Analysis Software Technologies for Astrophysical Research Involving Large Data Bases

    NASA Technical Reports Server (NTRS)

    Djorgovski, S. G.

    1994-01-01

    We developed a package to process and analyze the data from the digital version of the Second Palomar Sky Survey. This system, called SKICAT, incorporates the latest in machine learning and expert systems software technology, in order to classify the detected objects objectively and uniformly, and facilitate handling of the enormous data sets from digital sky surveys and other sources. The system provides a powerful, integrated environment for the manipulation and scientific investigation of catalogs from virtually any source. It serves three principal functions: image catalog construction, catalog management, and catalog analysis. Through use of the GID3* Decision Tree artificial induction software, SKICAT automates the process of classifying objects within CCD and digitized plate images. To exploit these catalogs, the system also provides tools to merge them into a large, complex database which may be easily queried and modified when new data or better methods of calibrating or classifying become available. The most innovative feature of SKICAT is the facility it provides to experiment with and apply the latest in machine learning technology to the tasks of catalog construction and analysis. SKICAT provides a unique environment for implementing these tools for any number of future scientific purposes. Initial scientific verification and performance tests have been made using galaxy counts and measurements of galaxy clustering from small subsets of the survey data, and a search for very high redshift quasars. All of the tests were successful and produced new and interesting scientific results. Attachments to this report give detailed accounts of the technical aspects of the SKICAT system, and of some of the scientific results achieved to date. We also developed a user-friendly package for multivariate statistical analysis of small and moderate-size data sets, called STATPROG. The package was tested extensively on a number of real scientific applications and has

  7. Mild clinical involvement in two males with a large FMR1 premutation

    SciTech Connect

    Hagerman, R.; O`Connor, R.; Staley, L.

    1994-09-01

    Both male and female individuals who carry the FMR1 premutation are considered to be clinically unaffected and have been reported to have normal transcription of their FMR1 gene and normal FMR1 protein (FMRP) production. We have evaluated two males who are mildly affected clinically with features of fragile X syndrome and demonstrate a large premutation on DNA studies. The first patient is a 2 year 8 month old boy who demonstrated the fragile X chromosome in 3% of his lymphocytes on cytogenetic testing. His physical features include mildly prominent ears and hyperextensible finger joints. He has language delays along with behavioral problems including tantrums and attention deficit. Developmental testing revealed a mental scale of 116 on the Bayley Scales of Infant Development, which is in the normal range. DNA testing demonstrated a premutation with 161 CGG repeats. This premutation was methylated in a small percent of his cells (<2%). These findings were observed in both blood leukocytes and buccal cells. Protein studies of transformed lymphocytes from this boy showed approximately 50 to 70% of the normal level of FMRP. The second patient is a 14 year old male who was cytogenetically negative for fragile X expression. His physical exam demonstrates a long face, a high palate and macroorchidism, (testicular volume of approximately 35 ml). His overall full scale IQ on the WISC-III is 73. He has language deficits and visual spatial perceptual deficits which have caused significant learning problems in school. Behaviorally he has problems with shyness and social anxiety, although he does not have attention deficit hyperactivity disorder. DNA testing revealed an FMR1 mutation of approximately 210 CGG repeats that is methylated in 4.7% of his cells.

  8. Transportation accident scenarios for commercial spent fuel

    SciTech Connect

    Wilmot, E L

    1981-02-01

    A spectrum of high severity, low probability, transportation accident scenarios involving commercial spent fuel is presented together with mechanisms, pathways and quantities of material that might be released from spent fuel to the environment. These scenarios are based on conclusions from a workshop, conducted in May 1980 to discuss transportation accident scenarios, in which a group of experts reviewed and critiqued available literature relating to spent fuel behavior and cask response in accidents.

  9. World commercial aircraft accidents. Second edition, 1946--1992

    SciTech Connect

    Kimura, C.Y.

    1993-01-01

    This report is a compilation of all accidents world-wide involving aircraft in commercial service which resulted in the loss of the airframe or one or more fatality, or both. This information has been gathered in order to present a complete inventory of commercial aircraft accidents. Events involving military action, sabotage, terrorist bombings, hijackings, suicides, and industrial ground accidents are included within this list. Included are: accidents involving world commercial jet aircraft, world commercial turboprop aircraft, world commercial pistonprop aircraft with four or more engines and world commercial pistonprop aircraft with two or three engines from 1946 to 1992. Each accident is presented with information in the following categories: date of the accident, airline and its flight numbers, type of flight, type of aircraft, aircraft registration number, construction number/manufacturers serial number, aircraft damage, accident flight phase, accident location, number of fatalities, number of occupants, cause, remarks, or description (brief) of the accident, and finally references used. The sixth chapter presents a summary of the world commercial aircraft accidents by major aircraft class (e.g. jet, turboprop, and pistonprop) and by flight phase. The seventh chapter presents several special studies including a list of world commercial aircraft accidents for all aircraft types with 100 or more fatalities in order of decreasing number of fatalities, a list of collision accidents involving commercial aircrafts, and a list of world commercial aircraft accidents for all aircraft types involving military action, sabotage, terrorist bombings, and hijackings.

  10. Source terms for plutonium aerosolization from nuclear weapon accidents

    SciTech Connect

    Stephens, D.R.

    1995-07-01

    The source term literature was reviewed to estimate aerosolized and respirable release fractions for accidents involving plutonium in high-explosive (HE) detonation and in fuel fires. For HE detonation, all estimates are based on the total amount of Pu. For fuel fires, all estimates are based on the amount of Pu oxidized. I based my estimates for HE detonation primarily upon the results from the Roller Coaster experiment. For hydrocarbon fuel fire oxidation of plutonium, I based lower bound values on laboratory experiments which represent accident scenarios with very little turbulence and updraft of a fire. Expected values for aerosolization were obtained from the Vixen A field tests, which represent a realistic case for modest turbulence and updraft, and for respirable fractions from some laboratory experiments involving large samples of Pu. Upper bound estimates for credible accidents are based on experiments involving combustion of molten plutonium droplets. In May of 1991 the DOE Pilot Safety Study Program established a group of experts to estimate the fractions of plutonium which would be aerosolized and respirable for certain nuclear weapon accident scenarios.

  11. Accident Flying Squad

    PubMed Central

    Snook, Roger

    1972-01-01

    This paper describes the organization, evaluation, and costing of an independently financed and operated accident flying squad. 132 accidents involving 302 casualties were attended, six deaths were prevented, medical treatment contributed to the survival of a further four, and the condition or comfort of many other casualties was improved. The calls in which survival was influenced were evenly distributed throughout the three-and-a-half-year survey and seven of the 10 so aided were over 16 and under 30 years of age, all 10 being in the working age group. The time taken to provide the service was not excessive and the expense when compared with the overall saving was very small. The scheme was seen to be equally suitable for basing on hospital or general practice or both, and working as an integrated team with the ambulance service. The use of specialized transport was found to be unnecessary. Other benefits of the scheme included use of the experience of attending accidents to ensure relevant and realistic training for emergency service personnel, and an appreciation of the effect of ambulance design on the patient. ImagesFIG. 1FIG. 4 PMID:5069642

  12. Normal Accident at Three Mile Island.

    ERIC Educational Resources Information Center

    Perrow, Charles

    1981-01-01

    Discusses some aspects of the accident at the Three Mile Island nuclear power plant. Explains a number of factors involved including the type of accident, warnings, design and equipment failure, operator error, and negative synergy. Presents alternatives to systems with catastrophic potential. (MK)

  13. 22 CFR 102.8 - Reporting accidents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Accidents Abroad § 102.8 Reporting accidents. (a) To airline and Civil Aeronautics Administration representatives. If a scheduled United States air carrier is involved the airline representatives concerned will... promptly to the nearest office of the airline concerned and to the nearest office of the Civil...

  14. 22 CFR 102.8 - Reporting accidents.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Accidents Abroad § 102.8 Reporting accidents. (a) To airline and Civil Aeronautics Administration representatives. If a scheduled United States air carrier is involved the airline representatives concerned will... promptly to the nearest office of the airline concerned and to the nearest office of the Civil...

  15. Statistical process control charts for attribute data involving very large sample sizes: a review of problems and solutions.

    PubMed

    Mohammed, Mohammed A; Panesar, Jagdeep S; Laney, David B; Wilson, Richard

    2013-04-01

    The use of statistical process control (SPC) charts in healthcare is increasing. The primary purpose of SPC is to distinguish between common-cause variation which is attributable to the underlying process, and special-cause variation which is extrinsic to the underlying process. This is important because improvement under common-cause variation requires action on the process, whereas special-cause variation merits an investigation to first find the cause. Nonetheless, when dealing with attribute or count data (eg, number of emergency admissions) involving very large sample sizes, traditional SPC charts often produce tight control limits with most of the data points appearing outside the control limits. This can give a false impression of common and special-cause variation, and potentially misguide the user into taking the wrong actions. Given the growing availability of large datasets from routinely collected databases in healthcare, there is a need to present a review of this problem (which arises because traditional attribute charts only consider within-subgroup variation) and its solutions (which consider within and between-subgroup variation), which involve the use of the well-established measurements chart and the more recently developed attribute charts based on Laney's innovative approach. We close by making some suggestions for practice. PMID:23365140

  16. Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure

    PubMed Central

    Christophersen, Olav Albert

    2012-01-01

    There are several animal experiments showing that high doses of ionizing radiation lead to strongly enhanced leakage of taurine from damaged cells into the extracellular fluid, followed by enhanced urinary excretion. This radiation-induced taurine depletion can itself have various harmful effects (as will also be the case when taurine depletion is due to other causes, such as alcohol abuse or cancer therapy with cytotoxic drugs), but taurine supplementation has been shown to have radioprotective effects apparently going beyond what might be expected just as a consequence of correcting the harmful consequences of taurine deficiency per se. The mechanisms accounting for the radioprotective effects of taurine are, however, very incompletely understood. In this article an attempt is made to survey various mechanisms that potentially might be involved as parts of the explanation for the overall beneficial effect of high levels of taurine that has been found in experiments with animals or isolated cells exposed to high doses of ionizing radiation. It is proposed that taurine may have radioprotective effects by a combination of several mechanisms: (1) during the exposure to ionizing radiation by functioning as an antioxidant, but perhaps more because it counteracts the prooxidant catalytic effect of iron rather than functioning as an important scavenger of harmful molecules itself, (2) after the ionizing radiation exposure by helping to reduce the intensity of the post-traumatic inflammatory response, and thus reducing the extent of tissue damage that develops because of severe inflammation rather than as a direct effect of the ionizing radiation per se, (3) by functioning as a growth factor helping to enhance the growth rate of leukocytes and leukocyte progenitor cells and perhaps also of other rapidly proliferating cell types, such as enterocyte progenitor cells, which may be important for immunological recovery and perhaps also for rapid repair of various damaged

  17. Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure

    PubMed Central

    Christophersen, Olav Albert

    2012-01-01

    There are several animal experiments showing that high doses of ionizing radiation lead to strongly enhanced leakage of taurine from damaged cells into the extracellular fluid, followed by enhanced urinary excretion. This radiation-induced taurine depletion can itself have various harmful effects (as will also be the case when taurine depletion is due to other causes, such as alcohol abuse or cancer therapy with cytotoxic drugs), but taurine supplementation has been shown to have radioprotective effects apparently going beyond what might be expected just as a consequence of correcting the harmful consequences of taurine deficiency per se. The mechanisms accounting for the radioprotective effects of taurine are, however, very incompletely understood. In this article an attempt is made to survey various mechanisms that potentially might be involved as parts of the explanation for the overall beneficial effect of high levels of taurine that has been found in experiments with animals or isolated cells exposed to high doses of ionizing radiation. It is proposed that taurine may have radioprotective effects by a combination of several mechanisms: (1) during the exposure to ionizing radiation by functioning as an antioxidant, but perhaps more because it counteracts the prooxidant catalytic effect of iron rather than functioning as an important scavenger of harmful molecules itself, (2) after the ionizing radiation exposure by helping to reduce the intensity of the post-traumatic inflammatory response, and thus reducing the extent of tissue damage that develops because of severe inflammation rather than as a direct effect of the ionizing radiation per se, (3) by functioning as a growth factor helping to enhance the growth rate of leukocytes and leukocyte progenitor cells and perhaps also of other rapidly proliferating cell types, such as enterocyte progenitor cells, which may be important for immunological recovery and perhaps also for rapid repair of various damaged

  18. 43 CFR 15.13 - Report of accidents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Report of accidents. 15.13 Section 15.13 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.13 Report of accidents. Accidents involving injury to life or property shall be reported as soon as...

  19. 43 CFR 15.13 - Report of accidents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Report of accidents. 15.13 Section 15.13 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.13 Report of accidents. Accidents involving injury to life or property shall be reported as soon as...

  20. 43 CFR 15.13 - Report of accidents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Report of accidents. 15.13 Section 15.13 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.13 Report of accidents. Accidents involving injury to life or property shall be reported as soon as...

  1. 43 CFR 15.13 - Report of accidents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Report of accidents. 15.13 Section 15.13 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.13 Report of accidents. Accidents involving injury to life or property shall be reported as soon as...

  2. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Post-accident testing. 382.303 Section 382.303... ALCOHOL USE AND TESTING Tests Required § 382.303 Post-accident testing. (a) As soon as practicable... functions with respect to the vehicle, if the accident involved the loss of human life; or (2) Who...

  3. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Post-accident testing. 382.303 Section 382.303... ALCOHOL USE AND TESTING Tests Required § 382.303 Post-accident testing. (a) As soon as practicable... functions with respect to the vehicle, if the accident involved the loss of human life; or (2) Who...

  4. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Post-accident testing. 382.303 Section 382.303... ALCOHOL USE AND TESTING Tests Required § 382.303 Post-accident testing. (a) As soon as practicable... functions with respect to the vehicle, if the accident involved the loss of human life; or (2) Who...

  5. 43 CFR 15.13 - Report of accidents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Report of accidents. 15.13 Section 15.13 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.13 Report of accidents. Accidents involving injury to life or property shall be reported as soon as...

  6. Involving parents from the start: Formative evaluation for a large RCT with Botswana Junior Secondary School students

    PubMed Central

    Miller, Kim S.; Chirwa-Motswere, Catherine; Winskell, Kate; Stallcup, Elizabeth

    2016-01-01

    While HIV prevention research conducted among adolescent populations may encounter parental resistance, the active engagement of parents from inception to trial completion may alleviate opposition. In preparation for implementing a large randomized controlled trial (RCT) examining the efficacy of a behavioural intervention targeting adolescent sexual risk behaviours, a formative evaluation was undertaken to assess parental reactions to the proposed trial. Six focus groups were conducted with parents of adolescents (aged 13–17) from rural, peri-urban, and urban Botswana junior secondary schools. Focus groups explored comprehension and acceptability among parents of the forthcoming trial including HSV-2 testing, the return of results to the adolescent (not the parent), trial information materials and the parental consent process. Parents welcomed the study and understood and accepted its moral and ethical considerations. Their reactions regarding return of HSV-2 results only to adolescents (not the parent) were mixed. Parents understood the consent process and most agreed to consent, while indicating their desire to remain informed and involved throughout the RCT. The FGDs provided valuable information and insights that helped strengthen the study. As a result of parents’ feedback, counselling procedures were strengthened and direct linkages to local services and care were made. Informational materials were revised to increase clarity, and materials and procedures were developed to encourage and support parental involvement and parent-child dialogue. Ultimately, parental feedback led to a decision by the Government of Botswana to allow parents to access their child’s HSV-2 test results. PMID:27002354

  7. Pulmonary lymphangioleiomyomatosis: unusual manifestations of multiple large pulmonary nodules with retroperitoneal lymph node involvement mimicking metastatic malignancy.

    PubMed

    Kim, Hye-Jung; Lee, Chang-Hoon; Kim, Yong-A; Han, Daehee; Moon, Hyeon Jong; Cheon, Hey Won; Chung, Hee Soon; Kim, Deog Kyeom

    2009-01-01

    Pulmonary lymphangioleiomyomatosis (LAM) is a rare, idiopathic disorder that predominantly affects the lung parenchyma of women of childbearing age. While the characteristic radiographic finding of pulmonary LAM consists of multiple well-defined thin-walled cysts, we describe a very unusual case of pulmonary LAM with multiple bilateral large pulmonary nodules and retroperitoneal involvement mimicking metastatic malignancy. A 48-year-old woman who had never smoked with a history of bilateral pneumothorax presented with progressive exertional dyspnea and abdominal discomfort. Imaging studies revealed multiple enlarged retroperitoneal lymph nodes, ascites and bilateral multiple large pulmonary nodules ranging from 3 to 18 mm in diameter. Exploratory laparoscopic surgery for intra-abdominal lesions and video-assisted thoracoscopic wedge resection of lung nodules were carried out to rule out metastatic malignancy. Pathology showed benign looking smooth muscle cell proliferation and immunoreactivity for α-smooth muscle actin and HMB-45 in both specimens. After treatment with GnRH antagonist, the patient was well over a 6-month period without evidence of disease progression.

  8. Designing an Experimental "Accident"

    ERIC Educational Resources Information Center

    Picker, Lester

    1974-01-01

    Describes an experimental "accident" that resulted in much student learning, seeks help in the identification of nematodes, and suggests biology teachers introduce similar accidents into their teaching to stimulate student interest. (PEB)

  9. Large-eddy simulation of turbulent winds during the Fukushima Daiichi Nuclear Power Plant accident by coupling with a meso-scale meteorological simulation model

    NASA Astrophysics Data System (ADS)

    Nakayama, H.; Takemi, T.; Nagai, H.

    2015-06-01

    A significant amount of radioactive material was accidentally discharged into the atmosphere from the Fukushima Dai-ichi Nuclear Power Plant from 12 March 2011, which produced high contaminated areas over a wide region in Japan. In conducting regional-scale atmospheric dispersion simulations, the computer-based nuclear emergency response system WSPEEDI-II developed by Japan Atomic Energy Agency was used. Because this system is driven by a meso-scale meteorological (MM) model, it is difficult to reproduce small-scale wind fluctuations due to the effects of local terrain variability and buildings within a nuclear facility that are not explicitly represented in MM models. In this study, we propose a computational approach to couple an LES-based CFD model with a MM model for detailed simulations of turbulent winds with buoyancy effects under real meteorological conditions using turbulent inflow technique. Compared to the simple measurement data, especially, the 10 min averaged wind directions of the LES differ by more than 30 degrees during some period of time. However, distribution patterns of wind speeds, directions, and potential temperature are similar to the MM data. This implies that our coupling technique has potential performance to provide detailed data on contaminated area in the nuclear accidents.

  10. Preliminary evaluation of the Accident Response Mobile Manipulation System for accident site salvage operations

    SciTech Connect

    Trujillo, J.M.; Morse, W.D.; Jones, D.P.

    1994-10-01

    This paper describes and evaluates operational experiences with the Accident Response Mobile Manipulation System (ARMMS) during simulated accident site salvage operations which might involve nuclear weapons. The ARMMS is based upon a teleoperated mobility platform with two Schilling Titan 7F Manipulators.

  11. Involved-Lesion Radiation Therapy After Chemotherapy in Limited-Stage Head-and-Neck Diffuse Large B Cell Lymphoma

    SciTech Connect

    Yu, Jeong Il; Nam, Heerim; Ahn, Yong Chan; Kim, Won Seog; Park, Keunchil; Kim, Seok Jin

    2010-10-01

    Purpose: To report treatment outcomes after combined-modality therapy in patients with Stage I/II head-and-neck (HN) diffuse large B cell lymphoma (DLBL). Methods and Materials: Eighty-six eligible patients received sequential chemotherapy and involved-lesion radiation therapy from 1995 to 2006. After a median of four cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or rituximab-plus-CHOP chemotherapy, a median of 41.4 Gy was delivered to the known initial gross lesion with adequate margin (2 to 3 cm). Results: After a median follow-up of 57 months, eight treatment failures were observed: distant metastasis in 8 patients; and locoregional failure in 4 patients. Among the 4 patients with locoregional failure, 3 presented with in-field failures, and 1 both in-field and out-of-field failure (contralateral neck). Rates of overall survival (OS) and freedom from progression (FFP) at 10 years were 74.1% and 88.9%, respectively. There was no severe side effect except 1 patient with Grade 3 mucositis during and after completion of radiation therapy. Multivariate analyses showed that absence of B symptom (p = 0.022) and normal lactate dehydrogenase (p = 0.017) were related to favorable OS, age >60 years (p = 0.033) was related to favorable FFP, and international prognostic index of 0 or 1 was related to favorable OS (p = 0.003) and FFP (p = 0.03). Conclusion: This study demonstrated that patients with Stage I/II HN DLBL did not need whole-neck irradiation. Involved-lesion radiation therapy might reduce radiation toxicity with favorable treatment results.

  12. Spectroscopic evidence of large aspherical β-NAT particles involved in denitrification in the December 2011 Arctic stratosphere

    NASA Astrophysics Data System (ADS)

    Woiwode, Wolfgang; Höpfner, Michael; Bi, Lei; Pitts, Michael C.; Poole, Lamont R.; Oelhaf, Hermann; Molleker, Sergej; Borrmann, Stephan; Klingebiel, Marcus; Belyaev, Gennady; Ebersoldt, Andreas; Griessbach, Sabine; Grooß, Jens-Uwe; Gulde, Thomas; Krämer, Martina; Maucher, Guido; Piesch, Christof; Rolf, Christian; Sartorius, Christian; Spang, Reinhold; Orphal, Johannes

    2016-07-01

    We analyze polar stratospheric cloud (PSC) signatures in airborne MIPAS-STR (Michelson Interferometer for Passive Atmospheric Sounding - STRatospheric aircraft) observations in the spectral regions from 725 to 990 and 1150 to 1350 cm-1 under conditions suitable for the existence of nitric acid trihydrate (NAT) above northern Scandinavia on 11 December 2011. The high-resolution infrared limb emission spectra of MIPAS-STR show a characteristic "shoulder-like" signature in the spectral region around 820 cm-1, which is attributed to the ν2 symmetric deformation mode of NO3- in β-NAT. Using radiative transfer calculations involving Mie and T-Matrix methods, the spectral signatures of spherical and aspherical particles are simulated. The simulations are constrained using collocated in situ particle measurements. Simulations assuming highly aspherical spheroids with aspect ratios (AR) of 0.1 or 10.0 and a lognormal particle mode with a mode radius of 4.8 µm reproduce the observed spectra to a high degree. A smaller lognormal mode with a mode radius of 2.0 µm, which is also taken into account, plays only a minor role. Within the scenarios analyzed, the best overall agreement is found for elongated spheroids with AR = 0.1. Simulations of spherical particles and spheroids with AR = 0.5 and 2.0 return results very similar to each other and do not allow us to reproduce the signature around 820 cm-1. The observed "shoulder-like" signature is explained by the combination of the absorption/emission and scattering characteristics of large highly aspherical β-NAT particles. The size distribution supported by our results corresponds to ˜ 9 ppbv of gas-phase equivalent HNO3 at the flight altitude of ˜ 18.5 km. The results are compared with the size distributions derived from the in situ observations, a corresponding Chemical Lagrangian Model of the Stratosphere (CLaMS) simulation, and excess gas-phase HNO3 observed in a nitrification layer directly below the observed PSC. The

  13. Human Factors in Cabin Accident Investigations

    NASA Technical Reports Server (NTRS)

    Chute, Rebecca D.; Rosekind, Mark R. (Technical Monitor)

    1996-01-01

    Human factors has become an integral part of the accident investigation protocol. However, much of the investigative process remains focussed on the flight deck, airframe, and power plant systems. As a consequence, little data has been collected regarding the human factors issues within and involving the cabin during an accident. Therefore, the possibility exists that contributing factors that lie within that domain may be overlooked. The FAA Office of Accident Investigation is sponsoring a two-day workshop on cabin safety accident investigation. This course, within the workshop, will be of two hours duration and will explore relevant areas of human factors research. Specifically, the three areas of discussion are: Information transfer and resource management, fatigue and other physical stressors, and the human/machine interface. Integration of these areas will be accomplished by providing a suggested checklist of specific cabin-related human factors questions for investigators to probe following an accident.

  14. Routine methods for post-transportation accident recovery of spent fuel casks

    SciTech Connect

    Shappert, L.B.; Pope, R.B. ); Best, R.E. ); Jones, R.H. , Los Gatos, CA )

    1991-01-01

    Spent fuel casks and other large radioactive material packages have been examined to determine whether the designs are adequate to allow the casks to be recovered using conventional recovery methods following a transportation accident. Casks and similar packages are typically designed with, and handled by, trunnions that support the package during transport. These trunnions are considered the best cask feature with which to grapple the cask once it is no longer in its usual shipping mode. Following a transport accident, the trunnions may be buried or entangled so that they are not readily accessible to initiate the recovery process. To evaluate the effectiveness of applying traditional recovery methods to spent fuel casks, a workshop was held in which a series of accidents involving casks were postulated; the modes of transportation considered included truck, rail, and barge. These participants knowledgeable in transport, handling, and, in some cases, recovery of large, heavy containers attended. Participants concluded that the physical recovery of a cask involved in an accident, irrespective of where the accident occurs, would be a straightforward rigging operation and that the addition of specific recovery features (e.g., additional trunnions) to the cask appears unnecessary.

  15. Routine methods for post-transportation accident recovery of spent fuel casks

    SciTech Connect

    Shappert, L.B.; Pope, R.B.; Best, R.E.; Jones, R.H.

    1991-12-31

    Spent fuel casks and other large radioactive material packages have been examined to determine whether the designs are adequate to allow the casks to be recovered using conventional recovery methods following a transportation accident. Casks and similar packages are typically designed with, and handled by, trunnions that support the package during transport. These trunnions are considered the best cask feature with which to grapple the cask once it is no longer in its usual shipping mode. Following a transport accident, the trunnions may be buried or entangled so that they are not readily accessible to initiate the recovery process. To evaluate the effectiveness of applying traditional recovery methods to spent fuel casks, a workshop was held in which a series of accidents involving casks were postulated; the modes of transportation considered included truck, rail, and barge. These participants knowledgeable in transport, handling, and, in some cases, recovery of large, heavy containers attended. Participants concluded that the physical recovery of a cask involved in an accident, irrespective of where the accident occurs, would be a straightforward rigging operation and that the addition of specific recovery features (e.g., additional trunnions) to the cask appears unnecessary.

  16. An operational centre for managing major chemical industrial accidents.

    PubMed

    Kiranoudis, C T; Kourniotis, S P; Christolis, M; Markatos, N C; Zografos, K G; Giannouli, I M; Androutsopoulos, K N; Ziomas, I; Kosmidis, E; Simeonidis, P; Poupkou, N

    2002-01-28

    The most important characteristic of major chemical accidents, from a societal perspective, is their tendency to produce off-site effects. The extent and severity of the accident may significantly affect the population and the environment of the adjacent areas. Following an accident event, effort should be made to limit such effects. Management decisions should be based on rational and quantitative information based on the site specific circumstances and the possible consequences. To produce such information we have developed an operational centre for managing large-scale industrial accidents. Its architecture involves an integrated framework of geographical information system (GIS) and RDBMS technology systems equipped with interactive communication capabilities. The operational centre was developed for Windows 98 platforms, for the region of Thriasion Pedion of West Attica, where the concentration of industrial activity and storage of toxic chemical is immense within areas of high population density. An appropriate case study is given in order to illuminate the use and necessity of the operational centre. PMID:11744201

  17. Cross-analysis of hazmat road accidents using multiple databases.

    PubMed

    Trépanier, Martin; Leroux, Marie-Hélène; de Marcellis-Warin, Nathalie

    2009-11-01

    Road selection for hazardous materials transportation relies heavily on risk analysis. With risk being generally expressed as a product of the probability of occurrence and the expected consequence, one will understand that risk analysis is data intensive. However, various authors have noticed the lack of statistical reliability of hazmat accident databases due to the systematic underreporting of such events. Also, official accident databases alone are not always providing all the information required (economical impact, road conditions, etc.). In this paper, we attempt to integrate many data sources to analyze hazmat accidents in the province of Quebec, Canada. Databases on dangerous goods accidents, road accidents and work accidents were cross-analyzed. Results show that accidents can hardly be matched and that these databases suffer from underreporting. Police records seem to have better coverage than official records maintained by hazmat authorities. Serious accidents are missing from government's official databases (some involving deaths or major spills) even though their declaration is mandatory.

  18. Cross-analysis of hazmat road accidents using multiple databases.

    PubMed

    Trépanier, Martin; Leroux, Marie-Hélène; de Marcellis-Warin, Nathalie

    2009-11-01

    Road selection for hazardous materials transportation relies heavily on risk analysis. With risk being generally expressed as a product of the probability of occurrence and the expected consequence, one will understand that risk analysis is data intensive. However, various authors have noticed the lack of statistical reliability of hazmat accident databases due to the systematic underreporting of such events. Also, official accident databases alone are not always providing all the information required (economical impact, road conditions, etc.). In this paper, we attempt to integrate many data sources to analyze hazmat accidents in the province of Quebec, Canada. Databases on dangerous goods accidents, road accidents and work accidents were cross-analyzed. Results show that accidents can hardly be matched and that these databases suffer from underreporting. Police records seem to have better coverage than official records maintained by hazmat authorities. Serious accidents are missing from government's official databases (some involving deaths or major spills) even though their declaration is mandatory. PMID:19819367

  19. Developing techniques for cause-responsibility analysis of occupational accidents.

    PubMed

    Jabbari, Mousa; Ghorbani, Roghayeh

    2016-11-01

    The aim of this study was to specify the causes of occupational accidents, determine social responsibility and the role of groups involved in work-related accidents. This study develops occupational accidents causes tree, occupational accidents responsibility tree, and occupational accidents component-responsibility analysis worksheet; based on these methods, it develops cause-responsibility analysis (CRA) techniques, and for testing them, analyzes 100 fatal/disabling occupational accidents in the construction setting that were randomly selected from all the work-related accidents in Tehran, Iran, over a 5-year period (2010-2014). The main result of this study involves two techniques for CRA: occupational accidents tree analysis (OATA) and occupational accidents components analysis (OACA), used in parallel for determination of responsible groups and responsibilities rate. From the results, we find that the management group of construction projects has 74.65% responsibility of work-related accidents. The developed techniques are purposeful for occupational accidents investigation/analysis, especially for the determination of detailed list of tasks, responsibilities, and their rates. Therefore, it is useful for preventing work-related accidents by focusing on the responsible group's duties.

  20. An Application of CICCT Accident Categories to Aviation Accidents in 1988-2004

    NASA Technical Reports Server (NTRS)

    Evans, Joni K.

    2007-01-01

    Interventions or technologies developed to improve aviation safety often focus on specific causes or accident categories. Evaluation of the potential effectiveness of those interventions is dependent upon mapping the historical aviation accidents into those same accident categories. To that end, the United States civil aviation accidents occurring between 1988 and 2004 (n=26,117) were assigned accident categories based upon the taxonomy developed by the CAST/ICAO Common Taxonomy Team (CICTT). Results are presented separately for four main categories of flight rules: Part 121 (large commercial air carriers), Scheduled Part 135 (commuter airlines), Non-Scheduled Part 135 (on-demand air taxi) and Part 91 (general aviation). Injuries and aircraft damage are summarized by year and by accident category.

  1. [Clinical examinations for the traffic accident patients].

    PubMed

    Hitosugi, Masahito

    2008-11-30

    Traffic accident is a leading cause of unintentional death and about six-thousands annually died in Japan. As about one-million of persons suffer from traffic injuries, most of them seek medical attention. Therefore, medical staffs have to find the injuries accurately and treat immediately. Furthermore, the cause of accident should also be considered; why the accident was occurred, human error of the driver? To solve these problems, clinical examinations were needed. Medical staffs have to understand the characteristics of the traffic injuries: severe and multiple blunt injuries, popular injuries can be estimated with considering the pattern of the accident. Because some of the accidents are occurred when the driver is under the influence of alcohol and other drugs, screening of these subjects should be performed. Because the public is largely unaware of the preventable nature of traffic injuries, in addition to diagnose and treat accurately, we medical staffs have to attend on the primary prevention of the traffic injuries.

  2. Involved Field Radiation After Autologous Stem Cell Transplant for Diffuse Large B-Cell Lymphoma in the Rituximab Era

    SciTech Connect

    Biswas, Tithi; Dhakal, Sughosh; Chen Rui; Hyrien, Ollivier; Bernstein, Steven; Friedberg, Jonathan W.; Fisher, Richard I.; Liesveld, Jane; Phillips, Gordon; Constine, Louis S.

    2010-05-01

    Purpose: For patients with recurrent or refractory large B-cell non-Hodgkin's lymphoma, high-dose chemotherapy and autologous stem cell transplant (ASCT) is the treatment of choice. We evaluated the role of involved field radiation therapy (IFRT) post-ASCT for patients initially induced with cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) or, more recently, rituximab-CHOP (R-CHOP). Materials and Methods: Between May 1992 and April 2005, 176 patients underwent ASCT for recurrent or refractory large B-cell non-Hodgkin's lymphoma; 164 patients were evaluable for endpoint analysis. Fifty percent of the CHOP group (n = 131), and 39% of the R-CHOP group (n = 33), received IFRT. Follow-up from the time of transplant was a median/mean of 1.7/3 years (range, 0.03-13 years). Results: The 5-year overall survival (OS) and disease-specific survival (DSS) improved with IFRT in both the R-CHOP (p = 0.006 and 0.02, respectively) and CHOP (p = 0.02 and p = 0.04, respectively) groups. IFRT was associated with a 10% (p = 0.17) reduction in local failure, alone or with a distant site. On univariate analysis, IFRT was associated with superior OS (hazard ratio [HR] = 0.50 [95% CI 0.32, 0.78]; p = 0.002) and DSS (HR = 0.53 [95% CI 0.33, 0.86]; p = 0.009). Presence of B symptoms was adverse (p = 0.03). On multivariate analysis, only IFRT was associated with significant improvement in OS (HR = 0.35 [0.18, 0.68]; p = 0.002) and DSS (HR = 0.39 [95% CI 0.18, 0.84]; p = 0.01). Conclusions: Recognizing that positive and negative patient selection bias exists for the use of IFRT post-ASCT, patients initially treated with CHOP or R-CHOP and who undergo ASCT for recurrent or refractory disease may benefit from subsequent IFRT presumably due to enhanced local control that can translate into a survival advantage.

  3. Analysis of surface powered haulage accidents, January 1990--July 1996

    SciTech Connect

    Fesak, G.M.; Breland, R.M.; Spadaro, J.

    1996-12-31

    This report addresses surface haulage accidents that occurred between January 1990 and July 1996 involving haulage trucks (including over-the-road trucks), front-end-loaders, scrapers, utility trucks, water trucks, and other mobile haulage equipment. The study includes quarries, open pits and surface coal mines utilizing self-propelled mobile equipment to transport personnel, supplies, rock, overburden material, ore, mine waste, or coal for processing. A total of 4,397 accidents were considered. This report summarizes the major factors that led to the accidents and recommends accident prevention methods to reduce the frequency of these accidents.

  4. Safety analysis of surface haulage accidents

    SciTech Connect

    Randolph, R.F.; Boldt, C.M.K.

    1996-12-31

    Research on improving haulage truck safety, started by the U.S. Bureau of Mines, is being continued by its successors. This paper reports the orientation of the renewed research efforts, beginning with an update on accident data analysis, the role of multiple causes in these accidents, and the search for practical methods for addressing the most important causes. Fatal haulage accidents most often involve loss of control or collisions caused by a variety of factors. Lost-time injuries most often involve sprains or strains to the back or multiple body areas, which can often be attributed to rough roads and the shocks of loading and unloading. Research to reduce these accidents includes improved warning systems, shock isolation for drivers, encouraging seatbelt usage, and general improvements to system and task design.

  5. Natural hazard impacts on transport systems: analyzing the data base of transport accidents in Russia

    NASA Astrophysics Data System (ADS)

    Petrova, Elena

    2015-04-01

    We consider a transport accident as any accident that occurs during transportation of people and goods. It comprises of accidents involving air, road, rail, water, and pipeline transport. With over 1.2 million people killed each year, road accidents are one of the world's leading causes of death; another 20-50 million people are injured each year on the world's roads while walking, cycling, or driving. Transport accidents of other types including air, rail, and water transport accidents are not as numerous as road crashes, but the relative risk of each accident is much higher because of the higher number of people killed and injured per accident. Pipeline ruptures cause large damages to the environment. That is why safety and security are of primary concern for any transport system. The transport system of the Russian Federation (RF) is one of the most extensive in the world. It includes 1,283,000 km of public roads, more than 600,000 km of airlines, more than 200,000 km of gas, oil, and product pipelines, 115,000 km of inland waterways, and 87,000 km of railways. The transport system, especially the transport infrastructure of the country is exposed to impacts of various natural hazards and weather extremes such as heavy rains, snowfalls, snowdrifts, floods, earthquakes, volcanic eruptions, landslides, snow avalanches, debris flows, rock falls, fog or icing roads, and other natural factors that additionally trigger many accidents. In June 2014, the Ministry of Transport of the RF has compiled a new version of the Transport Strategy of the RF up to 2030. Among of the key pillars of the Strategy are to increase the safety of the transport system and to reduce negative environmental impacts. Using the data base of technological accidents that was created by the author, the study investigates temporal variations and regional differences of the transport accidents' risk within the Russian federal regions and a contribution of natural factors to occurrences of different

  6. Visualization of Traffic Accidents

    NASA Technical Reports Server (NTRS)

    Wang, Jie; Shen, Yuzhong; Khattak, Asad

    2010-01-01

    Traffic accidents have tremendous impact on society. Annually approximately 6.4 million vehicle accidents are reported by police in the US and nearly half of them result in catastrophic injuries. Visualizations of traffic accidents using geographic information systems (GIS) greatly facilitate handling and analysis of traffic accidents in many aspects. Environmental Systems Research Institute (ESRI), Inc. is the world leader in GIS research and development. ArcGIS, a software package developed by ESRI, has the capabilities to display events associated with a road network, such as accident locations, and pavement quality. But when event locations related to a road network are processed, the existing algorithm used by ArcGIS does not utilize all the information related to the routes of the road network and produces erroneous visualization results of event locations. This software bug causes serious problems for applications in which accurate location information is critical for emergency responses, such as traffic accidents. This paper aims to address this problem and proposes an improved method that utilizes all relevant information of traffic accidents, namely, route number, direction, and mile post, and extracts correct event locations for accurate traffic accident visualization and analysis. The proposed method generates a new shape file for traffic accidents and displays them on top of the existing road network in ArcGIS. Visualization of traffic accidents along Hampton Roads Bridge Tunnel is included to demonstrate the effectiveness of the proposed method.

  7. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... functions with respect to the vehicle, if the accident involved the loss of human life; or (2) Who receives... performing safety-sensitive functions with respect to the vehicle, if the accident involved the loss of human... section. (g)(1) The results of a breath or blood test for the use of alcohol, conducted by Federal,...

  8. 49 CFR 382.303 - Post-accident testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... functions with respect to the vehicle, if the accident involved the loss of human life; or (2) Who receives... performing safety-sensitive functions with respect to the vehicle, if the accident involved the loss of human... section. (g)(1) The results of a breath or blood test for the use of alcohol, conducted by Federal,...

  9. 32 CFR 634.28 - Traffic accident investigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.28 Traffic... accidents described in this section: (a) Accidents involving Government vehicles or Government property on the installation involving a fatality, personal injury, or estimated property damage in the...

  10. Laser accidents: Being Prepared

    SciTech Connect

    Barat, K

    2003-01-24

    The goal of the Laser Safety Officer and any laser safety program is to prevent a laser accident from occurring, in particular an injury to a person's eyes. Most laser safety courses talk about laser accidents, causes, and types of injury. The purpose of this presentation is to present a plan for safety offices and users to follow in case of accident or injury from laser radiation.

  11. Learning lessons from Natech accidents - the eNATECH accident database

    NASA Astrophysics Data System (ADS)

    Krausmann, Elisabeth; Girgin, Serkan

    2016-04-01

    When natural hazards impact industrial facilities that house or process hazardous materials, fires, explosions and toxic releases can occur. This type of accident is commonly referred to as Natech accident. In order to prevent the recurrence of accidents or to better mitigate their consequences, lessons-learned type studies using available accident data are usually carried out. Through post-accident analysis, conclusions can be drawn on the most common damage and failure modes and hazmat release paths, particularly vulnerable storage and process equipment, and the hazardous materials most commonly involved in these types of accidents. These analyses also lend themselves to identifying technical and organisational risk-reduction measures that require improvement or are missing. Industrial accident databases are commonly used for retrieving sets of Natech accident case histories for further analysis. These databases contain accident data from the open literature, government authorities or in-company sources. The quality of reported information is not uniform and exhibits different levels of detail and accuracy. This is due to the difficulty of finding qualified information sources, especially in situations where accident reporting by the industry or by authorities is not compulsory, e.g. when spill quantities are below the reporting threshold. Data collection has then to rely on voluntary record keeping often by non-experts. The level of detail is particularly non-uniform for Natech accident data depending on whether the consequences of the Natech event were major or minor, and whether comprehensive information was available for reporting. In addition to the reporting bias towards high-consequence events, industrial accident databases frequently lack information on the severity of the triggering natural hazard, as well as on failure modes that led to the hazmat release. This makes it difficult to reconstruct the dynamics of the accident and renders the development of

  12. Two-tier Haddon matrix approach to fault analysis of accidents and cybernetic search for relationship to effect operational control: a case study at a large construction site.

    PubMed

    Mazumdar, Atmadeep; Sen, Krishna Nirmalya; Lahiri, Balendra Nath

    2007-01-01

    The Haddon matrix is a potential tool for recognizing hazards in any operating engineering system. This paper presents a case study of operational hazards at a large construction site. The fish bone structure helps to visualize and relate the chain of events, which led to the failure of the system. The two-tier Haddon matrix approach helps to analyze the problem and subsequently prescribes preventive steps. The cybernetic approach has been undertaken to establish the relationship among event variables and to identify the ones with most potential. Those event variables in this case study, based on the cybernetic concepts like control responsiveness and controllability salience, are (a) uncontrolled swing of sheet contributing to energy, (b) slippage of sheet from anchor, (c) restricted longitudinal and transverse swing or rotation about the suspension, (d) guilt or uncertainty of the crane driver, (e) safe working practices and environment.

  13. Chernobyl accident: A comprehensive risk assessment

    SciTech Connect

    Vargo, G.J.; Poyarkov, V.; Baryakhtar, V.; Kukhar, V.; Los, I.

    1999-11-01

    The authors, all of whom are Ukrainian and Russian scientists involved with Chernobyl nuclear power plant since the April 1986 accident, present a comprehensive review of the accident. In addition, they present a risk assessment of the remains of the destroyed reactor and its surrounding shelter, Chernobyl radioactive waste storage and disposal sites, and environmental contamination in the region. The authors explore such questions as the risks posed by a collapse of the shelter, radionuclide migration from storage and disposal facilities in the exclusion zone, and transfer from soil to vegetation and its potential regional impact. The answers to these questions provide a scientific basis for the development of countermeasures against the Chernobyl accident in particular and the mitigation of environmental radioactive contamination in general. They also provide an important basis for understanding the human health and ecological risks posed by the accident.

  14. Chernobyl accident: A comprehensive risk assessment

    SciTech Connect

    Vargo, G.J.; Poyarkov, V.; Baryakhtar, V.; Kukhar, V.; Los, I.

    1999-01-01

    The authors, all of whom are Ukrainian and Russian scientists involved with Chernobyl nuclear power plant since the April 1986 accident, present a comprehensive review of the accident. In addition, they present a risk assessment of the remains of the destroyed reactor and its surrounding shelter, Chernobyl radioactive waste storage and disposal sites, and environmental contamination in the region. The authors explore such questions as the risks posed by a collapse of the shelter, radionuclide migration from storage and disposal facilities in the exclusion zone, and transfer from soil to vegetation and its potential regional impact. The answers to these questions provide a scientific basis for the development of countermeasures against the Chernobyl accident in particular and the mitigation of environmental radioactive contamination in general. They also provide an important basis for understanding the human health and ecological risks posed by the accident.

  15. Bayes classifiers for imbalanced traffic accidents datasets.

    PubMed

    Mujalli, Randa Oqab; López, Griselda; Garach, Laura

    2016-03-01

    Traffic accidents data sets are usually imbalanced, where the number of instances classified under the killed or severe injuries class (minority) is much lower than those classified under the slight injuries class (majority). This, however, supposes a challenging problem for classification algorithms and may cause obtaining a model that well cover the slight injuries instances whereas the killed or severe injuries instances are misclassified frequently. Based on traffic accidents data collected on urban and suburban roads in Jordan for three years (2009-2011); three different data balancing techniques were used: under-sampling which removes some instances of the majority class, oversampling which creates new instances of the minority class and a mix technique that combines both. In addition, different Bayes classifiers were compared for the different imbalanced and balanced data sets: Averaged One-Dependence Estimators, Weightily Average One-Dependence Estimators, and Bayesian networks in order to identify factors that affect the severity of an accident. The results indicated that using the balanced data sets, especially those created using oversampling techniques, with Bayesian networks improved classifying a traffic accident according to its severity and reduced the misclassification of killed and severe injuries instances. On the other hand, the following variables were found to contribute to the occurrence of a killed causality or a severe injury in a traffic accident: number of vehicles involved, accident pattern, number of directions, accident type, lighting, surface condition, and speed limit. This work, to the knowledge of the authors, is the first that aims at analyzing historical data records for traffic accidents occurring in Jordan and the first to apply balancing techniques to analyze injury severity of traffic accidents.

  16. Civil aircraft accident investigation.

    PubMed

    Haines, Daniel

    2013-01-01

    This talk reviews some historic aircraft accidents and some more recent. It reflects on the division of accident causes, considering mechanical failures and aircrew failures, and on aircrew training. Investigation results may lead to improved aircraft design, and to appropriate crew training. PMID:24057309

  17. Anatomy of an Accident.

    ERIC Educational Resources Information Center

    Mobley, Michael

    1984-01-01

    The findings of industrial safety engineers in the areas of accident causation and prevention are wholly applicable to adventure programs. Adventure education instructors can use safety engineering concepts to assess the risk in a particular activity, understand factors that cause accidents, and intervene to minimize injuries and damages if…

  18. Farm accidents in children.

    PubMed Central

    Cameron, D.; Bishop, C.; Sibert, J. R.

    1992-01-01

    OBJECTIVE--To examine the problem of accidental injury to children on farms. DESIGN--Prospective county based study of children presenting to accident and emergency departments over 12 months with injuries sustained in a farm setting and nationwide review of fatal childhood farm accidents over the four years April 1986 to March 1990. SETTING--Accident and emergency departments in Aberystwyth, Carmarthen, Haverfordwest, and Llanelli and fatal accidents in England, Scotland, and Wales notified to the Health and Safety Executive register. SUBJECTS--Children aged under 16. MAIN OUTCOME MEASURE--Death or injury after farm related accidents. RESULTS--65 accidents were recorded, including 18 fractures. Nine accidents necessitated admission to hospital for a mean of two (range one to four) days. 13 incidents were related to tractors and other machinery; 24 were due to falls. None of these incidents were reported under the statutory notification scheme. 33 deaths were notified, eight related to tractors and allied machinery and 10 related to falling objects. CONCLUSIONS--Although safety is improving, the farm remains a dangerous environment for children. Enforcement of existing safety legislation with significant penalties and targeting of safety education will help reduce accident rates further. PMID:1638192

  19. Establishing User Needs--A Large-Scale Study into the Requirements of Those Involved in the Research Process

    ERIC Educational Resources Information Center

    Grimshaw, Shirley; Wilson, Ian

    2009-01-01

    The aim of the project was to develop a set of online tools, systems and processes that would facilitate research at the University of Nottingham. The tools would be delivered via a portal, a one-stop place providing a Virtual Research Environment for all those involved in the research process. A predominantly bottom-up approach was used with…

  20. Accidents related to manure in eastern Switzerland: an epidemiological study.

    PubMed Central

    Knoblauch, A; Steiner, B; Bachmann, S; Trachsler, G; Burgheer, R; Osterwalder, J

    1996-01-01

    OBJECTIVES: Liquid manure systems and manure pits are major hazards in the agricultural workplace. The incidence of accidents related to manure is unknown. The objective of this study was to survey the liquid manure facilities of farms in eastern Switzerland and find the incidence of accidents related to manure in the region. METHODS: Retrospective cohort study and cross sectional survey of 210 farms in eastern Switzerland. RESULTS: The incidence of accidents related to manure was found to be 10.4/1000 person-years. Most accidents were categorised as minor--that is, had a benign outcome for the people involved or involved animals only. One in 33 of the farms surveyed was the scene of an accident related to manure each year. CONCLUSIONS: The medical literature on accidents related to manure mostly reports accidents with catastrophic outcomes. This study shows that this type of accident is only the tip of the iceberg. Most of the accidents reported in this study belong to a category that has hitherto been un-noticed and unreported. The term "accident related to manure" covers a broad range of events, and those resulting in serious human illness or death represent only a small part of this spectrum. A wide variety of liquid manure systems were found on the farms surveyed. Very few liquid manure facilities conformed to published safety standards. PMID:8882112

  1. A comparison of two micro-beam X-ray emission techniques for actinide elemental distribution in microscopic particles originating from the hydrogen bombs involved in the Palomares (Spain) and Thule (Greenland) accidents

    NASA Astrophysics Data System (ADS)

    Jimenez-Ramos, M. C.; Eriksson, M.; García-López, J.; Ranebo, Y.; García-Tenorio, R.; Betti, M.; Holm, E.

    2010-09-01

    In order to validate and to gain confidence in two micro-beam techniques: particle induced X-ray emission with nuclear microprobe technique (μ-PIXE) and synchrotron radiation induced X-ray fluorescence in a confocal alignment (confocal SR μ-XRF) for characterization of microscopic particles containing actinide elements (mixed plutonium and uranium) a comparative study has been performed. Inter-comparison of the two techniques is essential as the X-ray production cross-sections for U and Pu are different for protons and photons and not well defined in the open literature, especially for Pu. The particles studied consisted of nuclear weapons material, and originate either in the so called Palomares accident in Spain, 1966 or in the Thule accident in Greenland, 1968. In the determination of the average Pu/U mass ratios (not corrected by self-absorption) in the analysed microscopic particles the results from both techniques show a very good agreement. In addition, the suitability of both techniques for the analysis with good resolution (down to a few μm) of the Pu/U distribution within the particles has been proved. The set of results obtained through both techniques has allowed gaining important information concerning the characterization of the remaining fissile material in the areas affected by the aircraft accidents. This type of information is essential for long-term impact assessments of contaminated sites.

  2. [Prevention of bicycle accidents].

    PubMed

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  3. [Prevention of bicycle accidents].

    PubMed

    Zwipp, H; Barthel, P; Bönninger, J; Bürkle, H; Hagemeister, C; Hannawald, L; Huhn, R; Kühn, M; Liers, H; Maier, R; Otte, D; Prokop, G; Seeck, A; Sturm, J; Unger, T

    2015-04-01

    For a very precise analysis of all injured bicyclists in Germany it would be important to have definitions for "severely injured", "seriously injured" and "critically injured". By this, e.g., two-thirds of surgically treated bicyclists who are not registered by the police could become available for a general analysis. Elderly bicyclists (> 60 years) are a minority (10 %) but represent a majority (50 %) of all fatalities. They profit most by wearing a helmet and would be less injured by using special bicycle bags, switching on their hearing aids and following all traffic rules. E-bikes are used more and more (145 % more in 2012 vs. 2011) with 600,000 at the end of 2011 and are increasingly involved in accidents but still have a lack of legislation. So even for pedelecs 45 with 500 W and a possible speed of 45 km/h there is still no legislative demand for the use of a protecting helmet. 96 % of all injured cyclists in Germany had more than 0.5 ‰ alcohol in their blood, 86 % more than 1.1 ‰ and 59 % more than 1.7 ‰. Fatalities are seen in 24.2 % of cases without any collision partner. Therefore the ADFC calls for a limit of 1.1 ‰. Some virtual studies conclude that integrated sensors in bicycle helmets which would interact with sensors in cars could prevent collisions or reduce the severity of injury by stopping the cars automatically. Integrated sensors in cars with opening angles of 180° enable about 93 % of all bicyclists to be detected leading to a high rate of injury avoidance and/or mitigation. Hanging lamps reduce with 35 % significantly bicycle accidents for children, traffic education for children and special trainings for elderly bicyclists are also recommended as prevention tools. As long as helmet use for bicyclists in Germany rates only 9 % on average and legislative orders for using a helmet will not be in force in the near future, coming up campaigns seem to be necessary to be promoted by the Deutscher

  4. Persistence of airline accidents.

    PubMed

    Barros, Carlos Pestana; Faria, Joao Ricardo; Gil-Alana, Luis Alberiko

    2010-10-01

    This paper expands on air travel accident research by examining the relationship between air travel accidents and airline traffic or volume in the period from 1927-2006. The theoretical model is based on a representative airline company that aims to maximise its profits, and it utilises a fractional integration approach in order to determine whether there is a persistent pattern over time with respect to air accidents and air traffic. Furthermore, the paper analyses how airline accidents are related to traffic using a fractional cointegration approach. It finds that airline accidents are persistent and that a (non-stationary) fractional cointegration relationship exists between total airline accidents and airline passengers, airline miles and airline revenues, with shocks that affect the long-run equilibrium disappearing in the very long term. Moreover, this relation is negative, which might be due to the fact that air travel is becoming safer and there is greater competition in the airline industry. Policy implications are derived for countering accident events, based on competition and regulation.

  5. Hepatic Resection as a Safe and Effective Treatment for Hepatocellular Carcinoma Involving a Single Large Tumor, Multiple Tumors, or Macrovascular Invasion

    PubMed Central

    Zhong, Jian-Hong; Rodríguez, A. Chapin; Ke, Yang; Wang, Yan-Yan; Wang, Lin; Li, Le-Qun

    2015-01-01

    Abstract This systematic review examined whether the available evidence justifies using hepatic resection (HR) during later stages of hepatocellular carcinoma (HCC), which contravenes treatment guidelines but is current practice at many medical centers. Official guidelines and retrospective studies recommend different roles for HR for patients with large/multinodular HCC or with HCC involving macrovascular invasion (MVI). Several databases were systematically searched for studies examining the safety and efficacy of HR for treating HCC involving a single large tumor (>5 cm) or multiple tumors, or for treating HCC involving MVI. We identified 50 studies involving 14 808 patients that investigated the use of HR to treat large/multinodular HCC, and 24 studies with 4389 patients that investigated HR to treat HCC with MVI. Median in-hospital mortality for patients with either type of HCC was significantly lower in Asian studies (2.7%) than in non-Asian studies (7.3%, P < 0.001). Median overall survival (OS) was significantly higher for all Asian patients with large/multinodular HCC than for all non-Asian patients at both 1 year (81% vs 65%, P < 0.001) and 5 years (42% vs 32%, P < 0.001). Similar results were obtained for median disease-free survival at 1 year (61% vs 50%, P < 0.001) and 5 years (26% vs 24%, P < 0.001). However, median OS was similar for Asian and non-Asian patients with HCC involving MVI at 1 year (50% vs 52%, P = 0.45) and 5 years (18% vs 14%, P = 0.94). There was an upward trend in 5-year OS in patients with either type of HCC. HR is reasonably safe and effective at treating large/multinodular HCC and HCC with MVI. The available evidence argues for expanding the indications for HR in official treatment guidelines. PMID:25621684

  6. Radiation accidents and their management: emphasis on the role of nuclear medicine professionals

    PubMed Central

    Novruzov, Fuad; Vinjamuri, Sobhan

    2014-01-01

    Large-scale radiation accidents are few in number, but those that have occurred have subsequently led to strict regulation in most countries. Here, different accident scenarios involving exposure to radiation have been reviewed. A triage of injured persons has been summarized and guidance on management has been provided in accordance with the early symptoms. Types of casualty to be expected in atomic blasts have been discussed. Management at the scene of an accident has been described, with explanation of the role of the radiation protection officer, the nature of contaminants, and monitoring for surface contamination. Methods for early diagnosis of radiation injuries have been then described. The need for individualization of treatment according to the nature and grade of the combined injuries has been emphasized, and different approaches to the treatment of internal contamination have been presented. The role of nuclear medicine professionals, including physicians and physicists, has been reviewed. It has been concluded that the management of radiation accidents is a very challenging process and that nuclear medicine physicians have to be well organized in order to deliver suitable management in any type of radiation accident. PMID:25004166

  7. Radiation accidents and their management: emphasis on the role of nuclear medicine professionals.

    PubMed

    Bomanji, Jamshed B; Novruzov, Fuad; Vinjamuri, Sobhan

    2014-10-01

    Large-scale radiation accidents are few in number, but those that have occurred have subsequently led to strict regulation in most countries. Here, different accident scenarios involving exposure to radiation have been reviewed. A triage of injured persons has been summarized and guidance on management has been provided in accordance with the early symptoms. Types of casualty to be expected in atomic blasts have been discussed. Management at the scene of an accident has been described, with explanation of the role of the radiation protection officer, the nature of contaminants, and monitoring for surface contamination. Methods for early diagnosis of radiation injuries have been then described. The need for individualization of treatment according to the nature and grade of the combined injuries has been emphasized, and different approaches to the treatment of internal contamination have been presented. The role of nuclear medicine professionals, including physicians and physicists, has been reviewed. It has been concluded that the management of radiation accidents is a very challenging process and that nuclear medicine physicians have to be well organized in order to deliver suitable management in any type of radiation accident.

  8. An unusually large aggressive adenomatoid odontogenic tumor of maxilla involving the third molar: A clinical case report

    PubMed Central

    Dhupar, Vikas; Akkara, Francis; Khandelwal, Pulkit

    2016-01-01

    Adenomatoid odontogenic tumor (AOT) is a rare tumor comprising only 3% of all odontogenic tumors. It is a benign, encapsulated, noninvasive, nonaggressive, slowly growing odontogenic lesion associated with an impacted tooth. These lesions may go unnoticed for years. The usual treatment is enucleation and curettage, and the lesion does not recur. Here, we present a rare case of an unusually large aggressive AOT of maxilla associated with impacted third molar. The authors also discuss clinical, radiographic, histopathologic, and therapeutic features of the case. Subtotal maxillectomy with simultaneous reconstruction of the surgical defect with temporalis myofascial flap was planned and carried out. PMID:27095910

  9. Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study.

    PubMed

    Williams, Denise; Mori, Tetsuya; Reiter, Alfred; Woessman, Wilhelm; Rosolen, Angelo; Wrobel, Grazyna; Zsiros, Jozsef; Uyttebroeck, Anne; Marky, Ildiko; Le Deley, Marie-Cécile; Brugières, Laurence

    2013-10-01

    In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi-agent chemotherapy, including high dose methotrexate, Ara-C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25-75%) and 74% (45-91%), respectively with a median follow up of 4.1 years. PMID:23720354

  10. 36 CFR 4.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Report of motor vehicle... INTERIOR VEHICLES AND TRAFFIC SAFETY § 4.4 Report of motor vehicle accident. (a) The operator of a motor... section do not relieve the operator and occupants of a motor vehicle involved in an accident of...

  11. 36 CFR 4.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Report of motor vehicle... INTERIOR VEHICLES AND TRAFFIC SAFETY § 4.4 Report of motor vehicle accident. (a) The operator of a motor... section do not relieve the operator and occupants of a motor vehicle involved in an accident of...

  12. 36 CFR 4.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Report of motor vehicle... INTERIOR VEHICLES AND TRAFFIC SAFETY § 4.4 Report of motor vehicle accident. (a) The operator of a motor... section do not relieve the operator and occupants of a motor vehicle involved in an accident of...

  13. 36 CFR 1004.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Report of motor vehicle accident. 1004.4 Section 1004.4 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in...

  14. 36 CFR 4.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INTERIOR VEHICLES AND TRAFFIC SAFETY § 4.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an accident resulting in property damage, personal injury or death shall report the... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Report of motor...

  15. 36 CFR 4.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR VEHICLES AND TRAFFIC SAFETY § 4.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an accident resulting in property damage, personal injury or death shall report the... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Report of motor...

  16. The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

    PubMed Central

    Papait, Roberto; Pistore, Christian; Grazini, Ursula; Babbio, Federica; Cogliati, Sara; Pecoraro, Daniela; Brino, Laurent; Morand, Anne-Laure; Dechampesme, Anne-Marie; Spada, Fabio; Leonhardt, Heinrich; McBlane, Fraser; Oudet, Pierre

    2008-01-01

    Heterochromatic chromosomal regions undergo large-scale reorganization and progressively aggregate, forming chromocenters. These are dynamic structures that rapidly adapt to various stimuli that influence gene expression patterns, cell cycle progression, and differentiation. Np95-ICBP90 (m- and h-UHRF1) is a histone-binding protein expressed only in proliferating cells. During pericentromeric heterochromatin (PH) replication, Np95 specifically relocalizes to chromocenters where it highly concentrates in the replication factories that correspond to less compacted DNA. Np95 recruits HDAC and DNMT1 to PH and depletion of Np95 impairs PH replication. Here we show that Np95 causes large-scale modifications of chromocenters independently from the H3:K9 and H4:K20 trimethylation pathways, from the expression levels of HP1, from DNA methylation and from the cell cycle. The PHD domain is essential to induce this effect. The PHD domain is also required in vitro to increase access of a restriction enzyme to DNA packaged into nucleosomal arrays. We propose that the PHD domain of Np95-ICBP90 contributes to the opening and/or stabilization of dense chromocenter structures to support the recruitment of modifying enzymes, like HDAC and DNMT1, required for the replication and formation of PH. PMID:18508923

  17. Muted protein is involved in the targeting of CD63 to large dense-core vesicles of chromaffin cells.

    PubMed

    Zhenhua, Hao; Wei, Li

    2016-08-01

    Large dense-core vesicles (LDCVs) are characterized as a class of lysosome-related organelles (LROs), which undergo regulated release and play important roles in development, metabolism and homeostasis. The Muted protein is a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), which functions in the biogenesis of lysosomes and LROs. CD63 is a membrane component of lysosomes and LROs. Whether and how CD63 is sorted into LDCVs is largely unknown. In this study, we aim to identify the localization of CD63 in chromaffin cells by colocalization, living cell imaging and cell fractionation. We found that a proportion of CD63-YFP colocalized with NPY-dsRed labeled LDCVs. By sucrose density gradient fractionation, a proportion of CD63 was found to be highly enriched in LDCVs fractions. The Muted mutant mouse is a model of Hermansky-Pudlak syndrome (HPS). We also found that the level of CD63 was significantly decreased in Muted-deficient adrenal glands, suggesting that the Muted protein is important for the steady-state level of CD63. Our results suggest that CD63 is a membrane component of LDCVs and the stability of CD63 is dependent on the Muted protein, which provides a clue to the pathogenesis of LRO defects in HPS. PMID:27531610

  18. Differences in passenger car and large truck involved crash frequencies at urban signalized intersections: an exploratory analysis.

    PubMed

    Dong, Chunjiao; Clarke, David B; Richards, Stephen H; Huang, Baoshan

    2014-01-01

    The influence of intersection features on safety has been examined extensively because intersections experience a relatively large proportion of motor vehicle conflicts and crashes. Although there are distinct differences between passenger cars and large trucks-size, operating characteristics, dimensions, and weight-modeling crash counts across vehicle types is rarely addressed. This paper develops and presents a multivariate regression model of crash frequencies by collision vehicle type using crash data for urban signalized intersections in Tennessee. In addition, the performance of univariate Poisson-lognormal (UVPLN), multivariate Poisson (MVP), and multivariate Poisson-lognormal (MVPLN) regression models in establishing the relationship between crashes, traffic factors, and geometric design of roadway intersections is investigated. Bayesian methods are used to estimate the unknown parameters of these models. The evaluation results suggest that the MVPLN model possesses most of the desirable statistical properties in developing the relationships. Compared to the UVPLN and MVP models, the MVPLN model better identifies significant factors and predicts crash frequencies. The findings suggest that traffic volume, truck percentage, lighting condition, and intersection angle significantly affect intersection safety. Important differences in car, car-truck, and truck crash frequencies with respect to various risk factors were found to exist between models. The paper provides some new or more comprehensive observations that have not been covered in previous studies.

  19. Helicopter sling load accident/incident survey: 1968 - 1974

    NASA Technical Reports Server (NTRS)

    Shaughnessy, J. D.; Pardue, M. D.

    1977-01-01

    During the period considered a mean of eleven accidents per year occurred and a mean of eleven persons were killed or seriously injured per year. Forty-one percent of the accidents occurred during hover, and 63 percent of the accidents had pilot error listed as a cause/factor. Many accidents involved pilots losing control of the helicopter or allowing a collision with obstructions to occur. There was a mean of 58 incidents each year and 51 percent of these occurred during cruise.

  20. Dose estimates in a loss of lead shielding truck accident.

    SciTech Connect

    Dennis, Matthew L.; Osborn, Douglas M.; Weiner, Ruth F.; Heames, Terence John

    2009-08-01

    The radiological transportation risk & consequence program, RADTRAN, has recently added an updated loss of lead shielding (LOS) model to it most recent version, RADTRAN 6.0. The LOS model was used to determine dose estimates to first-responders during a spent nuclear fuel transportation accident. Results varied according to the following: type of accident scenario, percent of lead slump, distance to shipment, and time spent in the area. This document presents a method of creating dose estimates for first-responders using RADTRAN with potential accident scenarios. This may be of particular interest in the event of high speed accidents or fires involving cask punctures.

  1. Accident resistant transport container

    DOEpatents

    Anderson, J.A.; Cole, K.K.

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  2. Accident resistant transport container

    DOEpatents

    Andersen, John A.; Cole, James K.

    1980-01-01

    The invention relates to a container for the safe air transport of plutonium having several intermediate wood layers and a load spreader intermediate an inner container and an outer shell for mitigation of shock during a hypothetical accident.

  3. Mathematical analysis and simulations involving chemotherapy and surgery on large human tumours under a suitable cell-kill functional response.

    PubMed

    Rodrigues, Diego Samuel; de Arruda Mancera, Paulo Fernando

    2013-02-01

    Dosage and frequency of treatment schedules are important for successful chemotherapy. However, in this work we argue that cell-kill response and tumoral growth should not be seen as separate and therefore are essential in a mathematical cancer model. This paper presents a mathematical model for sequencing of cancer chemotherapy and surgery. Our purpose is to investigate treatments for large human tumours considering a suitable cell-kill dynamics. We use some biological and pharmacological data in a numerical approach, where drug administration occurs in cycles (periodic infusion) and surgery is performed instantaneously. Moreover, we also present an analysis of stability for a chemotherapeutic model with continuous drug administration. According to Norton and Simon [22], our results indicate that chemotherapy is less efficient in treating tumours that have reached a plateau level of growing and that a combination with surgical treatment can provide better outcomes.

  4. New investigations around CYP11A1 and its possible involvement in an androstenone QTL characterised in Large White pigs

    PubMed Central

    2011-01-01

    Background Previously, in boars with extreme androstenone levels, differential expression of the CYP11A1 gene in the testes has been characterised. CYP11A1 is located in a region where a QTL influencing boar fat androstenone levels has been detected in a Large White pig population. Clarifying the role of CYP11A1 in boar taint is important because it catalyses the initial step of androstenone synthesis and also of steroid synthesis. Results A genome-wide association study located CYP11A1 at approximately 1300 kb upstream from SNP H3GA0021967, defining the centre of the region containing the QTL for androstenone variation. In this study, we partially sequenced the CYP11A1 gene and identified several new single nucleotide polymorphisms (SNP) within it. Characterisation of one animal, heterozygous for CYP11A1 testicular expression but homozygous for a haplotype of a large region containing CYP11A1, revealed that variation of CYP11A1 expression is probably regulated by a mutation located downstream from the SNP H3GA0021967. We analysed CYP11A1 expression in LW families according to haplotypes of the QTL region's centre. Effects of haplotypes on CYP11A1 expression and on androstenone accumulation were not concordant. Conclusion This study shows that testicular expression of CYP11A1 is not solely responsible for the QTL influencing boar fat androstenone levels. As a conclusion, we propose to refute the hypothesis that a single mutation located near the centre of the QTL region could control androstenone accumulation in fat by regulating the CYP11A1 expression. PMID:21504607

  5. Anthropotechnological analysis of industrial accidents in Brazil.

    PubMed Central

    Binder, M. C.; de Almeida, I. M.; Monteau, M.

    1999-01-01

    The Brazilian Ministry of Labour has been attempting to modify the norms used to analyse industrial accidents in the country. For this purpose, in 1994 it tried to make compulsory use of the causal tree approach to accident analysis, an approach developed in France during the 1970s, without having previously determined whether it is suitable for use under the industrial safety conditions that prevail in most Brazilian firms. In addition, opposition from Brazilian employers has blocked the proposed changes to the norms. The present study employed anthropotechnology to analyse experimental application of the causal tree method to work-related accidents in industrial firms in the region of Botucatu, São Paulo. Three work-related accidents were examined in three industrial firms representative of local, national and multinational companies. On the basis of the accidents analysed in this study, the rationale for the use of the causal tree method in Brazil can be summarized for each type of firm as follows: the method is redundant if there is a predominance of the type of risk whose elimination or neutralization requires adoption of conventional industrial safety measures (firm representative of local enterprises); the method is worth while if the company's specific technical risks have already largely been eliminated (firm representative of national enterprises); and the method is particularly appropriate if the firm has a good safety record and the causes of accidents are primarily related to industrial organization and management (multinational enterprise). PMID:10680249

  6. A framework for the assessment of severe accident management strategies

    SciTech Connect

    Kastenberg, W.E.; Apostolakis, G.; Dhir, V.K.

    1993-09-01

    Severe accident management can be defined as the use of existing and/or altemative resources, systems and actors to prevent or mitigate a core-melt accident. For each accident sequence and each combination of severe accident management strategies, there may be several options available to the operator, and each involves phenomenological and operational considerations regarding uncertainty. Operational uncertainties include operator, system and instrumentation behavior during an accident. A framework based on decision trees and influence diagrams has been developed which incorporates such criteria as feasibility, effectiveness, and adverse effects, for evaluating potential severe accident management strategies. The framework is also capable of propagating both data and model uncertainty. It is applied to several potential strategies including PWR cavity flooding, BWR drywell flooding, PWR depressurization and PWR feed and bleed.

  7. Cellular phones and traffic accidents: an epidemiological approach.

    PubMed

    Violanti, J M; Marshall, J R

    1996-03-01

    Using epidemiological case-control design and logistic regression techniques, this study examined the association of cellular phone use in motor vehicles and traffic accident risk. The amount of time per month spent talking on a cellular phone and 18 other driver inattention factors were examined. Data were obtained from: (1) a case group of 100 randomly selected drivers involved in accidents within the past 2 years, and (2) a control group of 100 randomly selected licensed drivers not involved in accidents within the past 10 years. Groups were matched on geographic residence. Approximately 13% (N = 7) of the accident and 9% (N = 7) of the non-accident group reported use of cellular phones while driving. Data was obtained from Department of Motor Vehicles accident reports and survey information from study subjects. We hypothesized that increased use of cellular phones while driving was associated with increased odds of a traffic accident. Results indicated that talking more than 50 minutes per month on cellular phones in a vehicle was associated with a 5.59-fold increased risk in a traffic accident. The combined use of cellular phones and motor and cognitive activities while driving were also associated with increased traffic accident risk. Readers should be cautioned that this study: (1) consists of a small sample, (2) reveals statistical associations and not causal relationships, and (3) does not conclude that talking on cellular phones while driving is inherently dangerous.

  8. The Impact of In-Vehicle Cell-Phone Use on Accidents or Near-Accidents among College Students.

    ERIC Educational Resources Information Center

    Seo, Dong-Chul; Torabi, Mohammad R.

    2004-01-01

    With in-vehicle use of cell phones rapidly increasing, the safety of young drivers, who represent 14% of licensed drivers but 26% of drivers involved in fatal crashes, may be disproportionately threatened. The authors used a questionnaire to examine the association between in-vehicle cell-phone use and accidents or near-accidents among 1,291…

  9. Transcriptomic and proteomic responses of Serratia marcescens to spaceflight conditions involve large-scale changes in metabolic pathways

    NASA Astrophysics Data System (ADS)

    Wang, Yajuan; Yuan, Yanting; Liu, Jinwen; Su, Longxiang; Chang, De; Guo, Yinghua; Chen, Zhenhong; Fang, Xiangqun; Wang, Junfeng; Li, Tianzhi; Zhou, Lisha; Fang, Chengxiang; Yang, Ruifu; Liu, Changting

    2014-04-01

    The microgravity environment of spaceflight expeditions has been associated with altered microbial responses. This study explores the characterization of Serratia marcescensis grown in a spaceflight environment at the phenotypic, transcriptomic and proteomic levels. From November 1, 2011 to November 17, 2011, a strain of S. marcescensis was sent into space for 398 h on the Shenzhou VIII spacecraft, and ground simulation was performed as a control (LCT-SM213). After the flight, two mutant strains (LCT-SM166 and LCT-SM262) were selected for further analysis. Although no changes in the morphology, post-culture growth kinetics, hemolysis or antibiotic sensitivity were observed, the two mutant strains exhibited significant changes in their metabolic profiles after exposure to spaceflight. Enrichment analysis of the transcriptome showed that the differentially expressed genes of the two spaceflight strains and the ground control strain mainly included those involved in metabolism and degradation. The proteome revealed that changes at the protein level were also associated with metabolic functions, such as glycolysis/gluconeogenesis, pyruvate metabolism, arginine and proline metabolism and the degradation of valine, leucine and isoleucine. In summary S. marcescens showed alterations primarily in genes and proteins that were associated with metabolism under spaceflight conditions, which gave us valuable clues for future research.

  10. Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes.

    PubMed

    Ribas, Gloria; González-Neira, Anna; Salas, Antonio; Milne, Roger L; Vega, Ana; Carracedo, Begoña; González, Emilio; Barroso, Eva; Fernández, Lara P; Yankilevich, Patricio; Robledo, Mercedes; Carracedo, Angel; Benítez, Javier

    2006-02-01

    One of the many potential uses of the HapMap project is its application to the investigation of complex disease aetiology among a wide range of populations. This study aims to assess the transferability of HapMap SNP data to the Spanish population in the context of cancer research. We have carried out a genotyping study in Spanish subjects involving 175 candidate cancer genes using an indirect gene-based approach and compared results with those for HapMap CEU subjects. Allele frequencies were very consistent between the two samples, with a high positive correlation (R) of 0.91 (P<1x10(-6)). Linkage disequilibrium patterns and block structures across each gene were also very similar, with disequilibrium coefficient (r (2)) highly correlated (R=0.95, P<1x10(-6)). We found that of the 21 genes that contained at least one block larger than 60 kb, nine (ATM, ATR, BRCA1, ERCC6, FANCC, RAD17, RAD50, RAD54B and XRCC4) belonged to the GO category "DNA repair". Haplotype frequencies per gene were also highly correlated (mean R=0.93), as was haplotype diversity (R=0.91, P<1x10(-6)). "Yin yang" haplotypes were observed for 43% of the genes analysed and 18% of those were identical to the ancestral haplotype (identified in Chimpazee). Finally, the portability of tagSNPs identified in the HapMap CEU data using pairwise r (2) thresholds of 0.8 and 0.5 was assessed by applying these to the Spanish and current HapMap data for 66 genes. In general, the HapMap tagSNPs performed very well. Our results show generally high concordance with HapMap data in allele frequencies and haplotype distributions and confirm the applicability of HapMap SNP data to the study of complex diseases among the Spanish population.

  11. The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates.

    PubMed

    Wilson, Corey J; Das, Payel; Clementi, Cecilia; Matthews, Kathleen S; Wittung-Stafshede, Pernilla

    2005-10-11

    To probe the experimental folding behavior of a large protein with complex topology, we created a monomeric variant of the lactose repressor protein (MLAc), a well characterized tetrameric protein that regulates transcription of the lac operon. Purified MLAc is folded, fully functional, and binds the inducer isopropyl beta-d-thiogalactoside with the same affinity as wild-type LacI. Equilibrium unfolding of MLAc induced by the chemical denaturant urea is a reversible, apparent two-state process (pH 7.5, 20 degrees C). However, time-resolved experiments demonstrate that unfolding is single-exponential, whereas refolding data indicate two transient intermediates. The data reveal the initial formation of a burst-phase (tau < ms) intermediate that corresponds to approximately 50% of the total secondary-structure content. This step is followed by a rearrangement reaction that is rate-limited by an unfolding process (tau approximately 3 s; pH 7.5, 20 degrees C) and results in a second intermediate. This MLAc intermediate converts to the native structure (tau approximately 30 s; pH 7.5, 20 degrees C). Remarkably, the experimental folding-energy landscape for MLAc is in excellent agreement with theoretical predictions using a simple topology-based C(alpha)-model as presented in a companion article in this issue. PMID:16203983

  12. The importance of large scale flood over the regular sedimentation in delta development: A case study involving Wax lake delta

    NASA Astrophysics Data System (ADS)

    Ullah, M. S.; Kolker, A.; Li, C.

    2011-12-01

    It has been widely hypothesized that catastrophic floods can play an important role in the development of a young and growing delta. This study examines the nature and rate of sediment deposition in the Wax lake delta in the Atchafalaya Basin of Louisiana during the Mississippi River flood of from April, 2011 to June, 2011. We hypothesize that the deposition rate that results from large scales floods in the Mississippi/Atchafalaya river outlets have a greater impact in the Wax lake delta development than the deposition rates that result from typical yearly sedimentation. Preliminary results from the cosmogenic 7Be counts from sediment collected from the delta show distinct regional and local sediment deposition patterns during the flood, and rates that are significantly higher when compared to the sedimentation rate of the last few decades. This application of cosmogenic 7Be to distinguish the sediment deposition rate provides a first-order understanding of the deltaic evolution and stratigraphic sequence development in a high-discharge setting.

  13. T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells.

    PubMed

    Azzaoui, Imane; Uhel, Fabrice; Rossille, Delphine; Pangault, Celine; Dulong, Joelle; Le Priol, Jerome; Lamy, Thierry; Houot, Roch; Le Gouill, Steven; Cartron, Guillaume; Godmer, Pascal; Bouabdallah, Krimo; Milpied, Noel; Damaj, Gandhi; Tarte, Karin; Fest, Thierry; Roussel, Mikael

    2016-08-25

    In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogeneous population described in inflammatory and infectious diseases and in numerous tumors including multiple myeloma, chronic lymphocytic leukemia, and DLBCL. However, their mechanisms of action remain unclear. We broadly assessed the presence and mechanisms of suppression of MDSC subsets in DLBCL. First, a myeloid suppressive signature was identified by gene expression profiling in DLBCL peripheral blood. Accordingly, we identified, in a cohort of 66 DLBCL patients, an increase in circulating G-MDSC (Lin(neg)HLA-DR(neg)CD33(pos)CD11b(pos)) and M-MDSC (CD14(pos)HLA-DR(low)) counts. Interestingly, only M-MDSC number was correlated with the International Prognostic Index, event-free survival, and number of circulating Tregs. Furthermore, T-cell proliferation was restored after monocyte depletion. Myeloid-dependent T-cell suppression was attributed to a release of interleukin-10 and S100A12 and increased PD-L1 expression. In summary, we identified expanded MDSC subsets in DLBCL, as well as new mechanisms of immunosuppression in DLBCL. PMID:27338100

  14. Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells

    PubMed Central

    Aranda, Sergi; Rutishauser, Dorothea; Ernfors, Patrik

    2014-01-01

    Pluripotency of embryonic stem cells (ESCs) is maintained by transcriptional activities and chromatin modifying complexes highly organized within the chromatin. Although much effort has been focused on identifying genome-binding sites, little is known on their dynamic association with chromatin across cell divisions. Here, we used a modified version of the iPOND (isolation of proteins at nascent DNA) technology to identify a large protein network enriched at nascent DNA in ESCs. This comprehensive and unbiased proteomic characterization in ESCs reveals that, in addition to the core replication machinery, proteins relevant for pluripotency of ESCs are present at DNA replication sites. In particular, we show that the chromatin remodeller HDAC1–NuRD complex is enriched at nascent DNA. Interestingly, an acute block of HDAC1 in ESCs leads to increased acetylation of histone H3 lysine 9 at nascent DNA together with a concomitant loss of methylation. Consistently, in contrast to what has been described in tumour cell lines, these chromatin marks were found to be stable during cell cycle progression of ESCs. Our results are therefore compatible with a rapid deacetylation-coupled methylation mechanism during the replication of DNA in ESCs that may participate in the preservation of pluripotency of ESCs during replication. PMID:24852249

  15. School Bus Accidents: Reducing Incidents and Injuries

    ERIC Educational Resources Information Center

    Mahoney, Daniel

    2009-01-01

    The number of children injured in nonfatal school bus accidents annually is more than double the number previously estimated. In Ohio alone, approximately 20,800 children younger than 18 were occupants of school buses that were involved in crashes in 2003 and 2004 (McGeehan 2007). Among those children, most had minor or no injuries. However, there…

  16. 49 CFR 659.33 - Accident notification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Agency § 659.33 Accident notification. (a) The oversight agency must require the rail transit agency to notify the oversight agency within two (2) hours of any incident involving a rail transit vehicle or taking place on rail transit-controlled property where one or more of the following occurs: (1)...

  17. 49 CFR 659.33 - Accident notification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Agency § 659.33 Accident notification. (a) The oversight agency must require the rail transit agency to notify the oversight agency within two (2) hours of any incident involving a rail transit vehicle or taking place on rail transit-controlled property where one or more of the following occurs: (1)...

  18. 49 CFR 659.33 - Accident notification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Agency § 659.33 Accident notification. (a) The oversight agency must require the rail transit agency to notify the oversight agency within two (2) hours of any incident involving a rail transit vehicle or taking place on rail transit-controlled property where one or more of the following occurs: (1)...

  19. 49 CFR 659.33 - Accident notification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Agency § 659.33 Accident notification. (a) The oversight agency must require the rail transit agency to notify the oversight agency within two (2) hours of any incident involving a rail transit vehicle or taking place on rail transit-controlled property where one or more of the following occurs: (1)...

  20. 49 CFR 659.33 - Accident notification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Agency § 659.33 Accident notification. (a) The oversight agency must require the rail transit agency to notify the oversight agency within two (2) hours of any incident involving a rail transit vehicle or taking place on rail transit-controlled property where one or more of the following occurs: (1)...

  1. Accident Tolerant Fuel Analysis

    SciTech Connect

    Curtis Smith; Heather Chichester; Jesse Johns; Melissa Teague; Michael Tonks; Robert Youngblood

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced “RISMC toolkit” that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional “accident-tolerant” (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and

  2. Accident tolerant fuel analysis

    SciTech Connect

    Smith, Curtis; Chichester, Heather; Johns, Jesse; Teague, Melissa; Tonks, Michael Idaho National Laboratory; Youngblood, Robert

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced ''RISMC toolkit'' that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional ''accident-tolerant'' (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and

  3. A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement.

    PubMed

    Bosch, Rosa; Moreno, María José; Dieguez-Gonzalez, Rebeca; Céspedes, María Virtudes; Gallardo, Alberto; Trias, Manuel; Grañena, Albert; Sierra, Jorge; Casanova, Isolda; Mangues, Ramon

    2013-08-01

    Central nervous system dissemination is a relatively uncommon but almost always fatal complication in diffuse large B-cell lymphoma patients. Optimal therapy for central nervous involvement in this malignancy has not been established. In this paper, we aimed to evaluate the therapeutic effect of E7123, a celecoxib derivative that inhibits focal adhesion signaling, in a novel xenograft model of diffuse large B-cell lymphoma with central nervous system involvement. Cells obtained after disaggregation of HT subcutaneous tumors (HT-SC cells) were intravenously injected in NOD/SCID mice. These mice received oral vehicle or 75 mg/kg of E7123 daily until they were euthanized for weight loss or signs of sickness. The antitumor effect of E7123 was validated in an independent experiment using a bioluminescent mouse model. Intravenously injected HT-SC cells showed higher take rate and higher central nervous system tropism (associated with increased expression of β1-integrin and p130Cas proteins) than HT cells. The oral administration of E7123 significantly increased survival time in 2 independent experiments using mice injected with unmodified or bioluminescent HT-SC cells. We have developed a new xenograft model of diffuse large B-cell lymphoma with central nervous system involvement that can be used in the pre-clinical evaluation of new drugs for this malignancy. E7123 is a new, well-tolerated and orally available therapeutic agent that merits further investigation since it may improve current management of diffuse large B-cell lymphoma patients with central nervous system involvement.

  4. The effectiveness of antilock braking systems in reducing accidents in Great Britain.

    PubMed

    Broughton, Jeremy; Baughan, Chris

    2002-05-01

    Antilock braking systems (ABS) are fitted to many new cars with the aims of improving their ability to steer while braking heavily and of reducing stopping distances on some road surfaces. This paper presents the findings of a project that assessed the effectiveness of ABS in reducing accidents in Great Britain. A large postal survey was carried out of the owners of modern cars. asking for details of any accidents in which they had been involved during the previous year as well as factors that might influence their likelihood of being involved in an accident. Questions were also asked to test respondents' knowledge of ABS. ABS cars ditfered in several respects from non-ABS cars, as did the two groups of drivers. Consequently, a sophisticated statistical analysis was required to provide unbiased estimates of the effectiveness of ABS. Various results did not achieve statistical significance, but the overall stability of the results indicates that real effects have been measured. They confirm that ABS does have the potential to reduce the number of accidents, but show that this has not been fully achieved. One reason may be that many drivers have little or no knowledge of ABS.

  5. Accident progression event tree analysis for postulated severe accidents at N Reactor

    SciTech Connect

    Wyss, G.D.; Camp, A.L.; Miller, L.A.; Dingman, S.E.; Kunsman, D.M. ); Medford, G.T. )

    1990-06-01

    A Level II/III probabilistic risk assessment (PRA) has been performed for N Reactor, a Department of Energy (DOE) production reactor located on the Hanford reservation in Washington. The accident progression analysis documented in this report determines how core damage accidents identified in the Level I PRA progress from fuel damage to confinement response and potential releases the environment. The objectives of the study are to generate accident progression data for the Level II/III PRA source term model and to identify changes that could improve plant response under accident conditions. The scope of the analysis is comprehensive, excluding only sabotage and operator errors of commission. State-of-the-art methodology is employed based largely on the methods developed by Sandia for the US Nuclear Regulatory Commission in support of the NUREG-1150 study. The accident progression model allows complex interactions and dependencies between systems to be explicitly considered. Latin Hypecube sampling was used to assess the phenomenological and systemic uncertainties associated with the primary and confinement system responses to the core damage accident. The results of the analysis show that the N Reactor confinement concept provides significant radiological protection for most of the accident progression pathways studied.

  6. Immediate medical consequences of nuclear accidents: lessons from Chernobyl

    SciTech Connect

    Gale, R.P.

    1987-08-07

    The immediate medical response to the nuclear accident at the Chernobyl nuclear power station involved containment of the radioactivity and evacuation of the nearby population. The next step consisted of assessment of the radiation dose received by individuals, based on biological dosimetry, and treatment of those exposed. Medical care involved treatment of skin burns; measures to support bone marrow failure, gastrointestinal tract injury, and other organ damage (i.e., infection prophylaxis and transfusions) for those with lower radiation dose exposure; and bone marrow transplantation for those exposed to a high dose of radiation. At Chernobyl, two victims died immediately and 29 died of radiation or thermal injuries in the next three months. The remaining victims of the accident are currently well. A nuclear accident anywhere is a nuclear accident everywhere. Prevention and cooperation in response to these accidents are essential goals.

  7. Lessons learned from early criticality accidents

    SciTech Connect

    Malenfant, R.E.

    1996-06-01

    Four accidents involving the approach to criticality occurred during the period July, 1945, through May, 1996. These have been described in the format of the OPERATING EXPERIENCE WEEKLY SUMMARY which is distributed by the Office of Nuclear and Facility Safety. Although the lessons learned have been incorporated in standards, codes, and formal procedures during the last fifty years, this is their first presentation in this format. It is particularly appropriate that they be presented in the forum of the Nuclear Criticality Technology Safety Project Workshop closest to the fiftieth anniversary of the last of the four accidents, and that which was most instrumental in demonstrating the need to incorporate lessons learned.

  8. Reconfigurable mobile manipulation for accident response

    SciTech Connect

    ANDERSON,ROBERT J.; MORSE,WILLIAM D.; SHIREY,DAVID L.; CDEBACA,DANIEL M.; HOFFMAN JR.,JOHN P.; LUCY,WILLIAM E.

    2000-06-06

    The need for a telerobotic vehicle with hazard sensing and integral manipulation capabilities has been identified for use in transportation accidents where nuclear weapons are involved. The Accident Response Mobile Manipulation System (ARMMS) platform has been developed to provide remote dexterous manipulation and hazard sensing for the Accident Response Group (ARG) at Sandia National Laboratories. The ARMMS' mobility platform is a military HMMWV [High Mobility Multipurpose Wheeled Vehicle] that is teleoperated over RF or Fiber Optic communication channels. ARMMS is equipped with two high strength Schilling Titan II manipulators and a suite of hazardous gas and radiation sensors. Recently, a modular telerobotic control architecture call SMART (Sandia Modular Architecture for Robotic and Teleoperation) has been applied to ARMMS. SMART enables input devices and many system behaviors to be rapidly configured in the field for specific mission needs. This paper summarizes current SMART developments applied to ARMMS.

  9. Accident prevention manual

    SciTech Connect

    Not Available

    1998-05-01

    Among the many common needs and goals are the safety and well-being of families, ourselves, fellow employees, and the continuing success of this organization. To these ends--minimizing human suffering and economic waste--the Bonneville Power Administration (BPA) Accident Prevention Program and this Accident Prevention Manual (APM) are dedicated. The BPA Accident Prevention Program is revised as necessary to ensure compliance with relevant Federal safety and health standards. The mandatory rules herein express minimum requirements for dealing with the principal hazards inherent in daily work activities. These and other written requirements, which neither can nor should provide complete coverage of all work situations, must be continually reinforced through the sound and mature safety judgments of all workers on each assigned task. In the event of conflicting judgments, the more conservative interpretation shall prevail pending review and resolution by management.

  10. Applicability of health physics lessons learned from the Three Mile Island Unit 2 accident to the Fukushima Daiichi accident.

    PubMed

    Bevelacqua, J J

    2012-02-01

    The TMI-2 and Fukushima Daiichi accidents appear to be dissimilar because they involve different reactor types. However, the health physics related lessons learned from TMI-2 are applicable, and can enhance the Fukushima Daiichi recovery effort. PMID:22230016

  11. NASA Medical Response to Human Spacecraft Accidents

    NASA Technical Reports Server (NTRS)

    Patlach, Robert

    2011-01-01

    This slide presentation reviews NASA's role in the response to spacecraft accidents that involve human fatalities or injuries. Particular attention is given to the work of the Mishap Investigation Team (MIT), the first response to the accidents and the interface to the accident investigation board. The MIT does not investigate the accident, but the objective of the MIT is to gather, guard, preserve and document the evidence. The primary medical objectives of the MIT is to receive, analyze, identify, and transport human remains, provide assistance in the recovery effort, and to provide family Casualty Coordinators with latest recovery information. The MIT while it does not determine the cause of the accident, it acts as the fact gathering arm of the Mishap Investigation Board (MIB), which when it is activated may chose to continue to use the MIT as its field investigation resource. The MIT membership and the specific responsibilities and tasks of the flight surgeon is reviewed. The current law establishing the process is also reviewed.

  12. Single pilot IFR accident data analysis

    NASA Technical Reports Server (NTRS)

    Harris, D. F.; Morrisete, J. A.

    1982-01-01

    The aircraft accident data recorded and maintained by the National Transportation Safety Board for 1964 to 1979 were analyzed to determine what problems exist in the general aviation single pilot instrument flight rules environment. A previous study conducted in 1978 for the years 1964 to 1975 provided a basis for comparison. The purpose was to determine what changes, if any, have occurred in trends and cause-effect relationships reported in the earlier study. The increasing numbers have been tied to measures of activity to produce accident rates which in turn were analyzed in terms of change. Where anomalies or unusually high accident rates were encountered, further analysis was conducted to isolate pertinent patterns of cause factors and/or experience levels of involved pilots. The bulk of the effort addresses accidents in the landing phase of operations. A detailed analysis was performed on controlled/uncontrolled collisions and their unique attributes delineated. Estimates of day vs. night general aviation activity and accident rates were obtained.

  13. The Fukushima radiation accident: consequences for radiation accident medical management.

    PubMed

    Meineke, Viktor; Dörr, Harald

    2012-08-01

    The March 2011 radiation accident in Fukushima, Japan, is a textbook example of a radiation accident of global significance. In view of the global dimensions of the accident, it is important to consider the lessons learned. In this context, emphasis must be placed on consequences for planning appropriate medical management for radiation accidents including, for example, estimates of necessary human and material resources. The specific characteristics of the radiation accident in Fukushima are thematically divided into five groups: the exceptional environmental influences on the Fukushima radiation accident, particular circumstances of the accident, differences in risk perception, changed psychosocial factors in the age of the Internet and globalization, and the ignorance of the effects of ionizing radiation both among the general public and health care professionals. Conclusions like the need for reviewing international communication, interfacing, and interface definitions will be drawn from the Fukushima radiation accident. PMID:22951483

  14. The Fukushima radiation accident: consequences for radiation accident medical management.

    PubMed

    Meineke, Viktor; Dörr, Harald

    2012-08-01

    The March 2011 radiation accident in Fukushima, Japan, is a textbook example of a radiation accident of global significance. In view of the global dimensions of the accident, it is important to consider the lessons learned. In this context, emphasis must be placed on consequences for planning appropriate medical management for radiation accidents including, for example, estimates of necessary human and material resources. The specific characteristics of the radiation accident in Fukushima are thematically divided into five groups: the exceptional environmental influences on the Fukushima radiation accident, particular circumstances of the accident, differences in risk perception, changed psychosocial factors in the age of the Internet and globalization, and the ignorance of the effects of ionizing radiation both among the general public and health care professionals. Conclusions like the need for reviewing international communication, interfacing, and interface definitions will be drawn from the Fukushima radiation accident.

  15. Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.

    PubMed

    Matsumoto, Kenjiro; Umemoto, Hiroyuki; Mori, Tomohisa; Akatsu, Ryuya; Saito, Shinichiro; Tashima, Kimihito; Shibasaki, Masahiro; Kato, Shinichi; Suzuki, Tsutomu; Horie, Syunji

    2016-01-15

    Constipation is the most common side effect of morphine. Morphine acts centrally and on peripheral sites within the enteric nervous system. There are a few comprehensive studies on morphine-induced constipation in the small and large intestine by the activation of central and peripheral μ-opioid receptors. We investigated the differences in the inhibition of the small and large intestinal transit in normal and morphine-tolerant mice. Morphine reduced the geometric center in the fluorescein isothiocyanate-dextran assay and prolonged the bead expulsion time in a dose-dependent manner. The inhibitory effects of morphine were blocked by μ-opioid antagonist β-funaltrexamine, but not by δ- and κ-opioid antagonists. The peripheral opioid receptor antagonist, naloxone methiodide, partially blocked morphine's effect in the small intestine and completely blocked its effect in the large intestine. The intracerebroventricular administration of naloxone significantly reversed the delay of small intestinal transit but did not affect morphine-induced inhibition of large intestinal transit. Naloxone methiodide completely reversed the inhibition of large intestinal transit in normal and morphine-tolerant mice. Naloxone methiodide partially reversed the morphine-induced inhibition of small intestinal transit in normal mice but completely reversed the effects of morphine in tolerant mice. Chronic treatment with morphine results in tolerance to its inhibitory effect on field-stimulated contraction in the isolated small intestine but not in the large intestine. These results suggest that peripheral and central opioid receptors are involved in morphine-induced constipation in the small and large intestine during the early stage of treatment, but the peripheral receptors mainly regulate constipation during long-term morphine treatment.

  16. Unusual involvement of scalp and bilateral kidneys in an aggressive mediastinal diffuse large B cell lymphoma: documentation by FDG-PET imaging.

    PubMed

    Basu, Sandip; Ramani, S K; Lad, S

    2009-09-01

    In the present communication, an unusual combination of scalp soft tissue and underlying brain involvement with intact skull bone coupled with bilateral renal involvement from a mediastinal diffuse large B cell lymphoma (DLBL) is presented. A 45-year-old man, a diagnosed case of mediastinal DLBL with bilateral lung involvement, was treated with conventional 6 cycles of chemotherapy and local external radiotherapy with initial good treatment response evidenced by considerable regression in mass size and regression in pulmonary lesions. Three months later, he returned with complaints of soft tissue swelling over the scalp; one of them in the high parietal bone and the other over the occipital region. A whole body FDG-PET at this time showed 2 moderate-sized foci in the scalp (with preservation of both tables of skull bone) and corresponding large foci in the brain parenchyma beneath, a superior mediastinal focus, a few foci in the apical and lower zone of left lung, extensive irregular uptake in the right pleura and the right lung parenchyma coupled with a loculated effusion in its lower zone and studded foci of hypermetabolism throughout the bilaterally enlarged kidneys. CT of the head confirmed the FDG-PET findings and histopathology of the biopsy from the scalp swelling was suggestive of DLBL. Ultrasound imaging of the abdomen showed lobulated bilaterally enlarged kidneys with multiple hypoechoic areas within them. The patient underwent palliative local external radiotherapy to the brain and systemic chemotherapy with poor clinical results with raised serum beta-2 microglobulin and serum LDH levels and deranged renal function. The patient died within a month after the FDG-PET study. The event of scalp and bilateral renal involvement from DLBL is rare in lymphoma literature and this report highlights that such unusual events can occur as part of widespread dissemination and underscores the importance of whole-body imaging with FDG-PET. PMID:19692836

  17. A Review of Criticality Accidents 2000 Revision

    SciTech Connect

    Thomas P. McLaughlin; Shean P. Monahan; Norman L. Pruvost; Vladimir V. Frolov; Boris G. Ryazanov; Victor I. Sviridov

    2000-05-01

    Criticality accidents and the characteristics of prompt power excursions are discussed. Sixty accidental power excursions are reviewed. Sufficient detail is provided to enable the reader to understand the physical situation, the chemistry and material flow, and when available the administrative setting leading up to the time of the accident. Information on the power history, energy release, consequences, and causes are also included when available. For those accidents that occurred in process plants, two new sections have been included in this revision. The first is an analysis and summary of the physical and neutronic features of the chain reacting systems. The second is a compilation of observations and lessons learned. Excursions associated with large power reactors are not included in this report.

  18. Occupational accidents aboard merchant ships

    PubMed Central

    Hansen, H; Nielsen, D; Frydenberg, M

    2002-01-01

    Objectives: To investigate the frequency, circumstances, and causes of occupational accidents aboard merchant ships in international trade, and to identify risk factors for the occurrence of occupational accidents as well as dangerous working situations where possible preventive measures may be initiated. Methods: The study is a historical follow up on occupational accidents among crew aboard Danish merchant ships in the period 1993–7. Data were extracted from the Danish Maritime Authority and insurance data. Exact data on time at risk were available. Results: A total of 1993 accidents were identified during a total of 31 140 years at sea. Among these, 209 accidents resulted in permanent disability of 5% or more, and 27 were fatal. The mean risk of having an occupational accident was 6.4/100 years at sea and the risk of an accident causing a permanent disability of 5% or more was 0.67/100 years aboard. Relative risks for notified accidents and accidents causing permanent disability of 5% or more were calculated in a multivariate analysis including ship type, occupation, age, time on board, change of ship since last employment period, and nationality. Foreigners had a considerably lower recorded rate of accidents than Danish citizens. Age was a major risk factor for accidents causing permanent disability. Change of ship and the first period aboard a particular ship were identified as risk factors. Walking from one place to another aboard the ship caused serious accidents. The most serious accidents happened on deck. Conclusions: It was possible to clearly identify work situations and specific risk factors for accidents aboard merchant ships. Most accidents happened while performing daily routine duties. Preventive measures should focus on workplace instructions for all important functions aboard and also on the prevention of accidents caused by walking around aboard the ship. PMID:11850550

  19. South African underwater diving accidents, 1969-1976.

    PubMed

    Landsberg, P G

    1976-12-25

    Since 1969 a survey of diving accidents involving South African amateur divers was undertaken. The South African Underwater Union diving accident report form was used, and various State agents (SA Police and inquest courts) and individual divers and club instructors were questioned. This survey covers the period up to the end of June 1976. Data acquired during the 8-year period 1969 - 1976 are compared. A conservative estimate from the number of certificates issued to club divers indicates a 25% increase in diver population, while the number of fatilities has decreased from 0,1% in 1971 to 0,016% in 1976, indicating the importance of accident reporting in determining safety trends. In general, a change in pattern is observed during the last 4 years, showing more SCUBA than breath-hold fatalities. The formation of the Decompression Sickness and Diving Accidents Investigation Panel as a further measure to decrease fatal diving accidents is discussed.

  20. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.

    PubMed

    Schaffer, Bethany E; Levin, Rebecca S; Hertz, Nicholas T; Maures, Travis J; Schoof, Michael L; Hollstein, Pablo E; Benayoun, Bérénice A; Banko, Max R; Shaw, Reuben J; Shokat, Kevan M; Brunet, Anne

    2015-11-01

    AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism and has been increasingly involved in non-metabolic processes and diseases. However, AMPK's direct substrates in non-metabolic contexts are largely unknown. To better understand the AMPK network, we use a chemical genetics screen coupled to a peptide capture approach in whole cells, resulting in identification of direct AMPK phosphorylation sites. Interestingly, the high-confidence AMPK substrates contain many proteins involved in cell motility, adhesion, and invasion. AMPK phosphorylation of the RHOA guanine nucleotide exchange factor NET1A inhibits extracellular matrix degradation, an early step in cell invasion. The identification of direct AMPK phosphorylation sites also facilitates large-scale prediction of AMPK substrates. We provide an AMPK motif matrix and a pipeline to predict additional AMPK substrates from quantitative phosphoproteomics datasets. As AMPK is emerging as a critical node in aging and pathological processes, our study identifies potential targets for therapeutic strategies. PMID:26456332

  1. Risk and preventive factors for fatalities in All-terrain Vehicle Accidents in New Zealand.

    PubMed

    Shulruf, Boaz; Balemi, Andrew

    2010-03-01

    All-Terrain Vehicles (ATVs) have been used in agriculture for a few decades now. Yet despite their invaluable contribution to the productivity of the agricultural industry they are associated with a large number of accidents, many of which result in a severe or fatal outcome. The main objective of this study was to identify the risk factors for ATV-related fatal injuries in order to support the design of effective interventions. Using data held by the Department of Labour, the current study analysed 355 cases of serious harm accidents associated with ATVs including 45 fatalities. The findings suggest that injuries are more likely to occur when accidents involve any of the following: children under the age of 10; four-wheel drive ATVs; driving downhill; driving on a sealed road; driving backwards; or if the ATV rolls sideways. A fatal outcome is more likely to occur when ATV accidents end up with the vehicle rolling over and pinning the driver underneath. Fatalities were also associated with injuries to the head, neck and chest. Being employed; and/or having formal training; and/or having brakes and tyres well maintained on the ATV; and/or having no fluid load on the ATV reduced the risk for fatality. Since the likelihood of a fatal outcome was found to be related to human behaviour and ATV rollover, it is suggested that interventions should mainly address these two issues.

  2. Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature

    PubMed Central

    Yu, Lu; Yan, Lin Li; Yang, Shou Jing

    2014-01-01

    Sarcomatoid variant of anaplastic large cell lymphoma (ALCL) is one of the rarest histologic variants of ALCL that consists of large, bizarre, often spindle-shaped, neoplastic cells resembling a soft tissue sarcoma. We report here such a case of ALCL with both pulmonary and multiple nodal involvement in a 47-year-old woman who initially presented with fever, cough, sputum, itching skin, and weight loss. The initial transbronchial lung biopsy showed discohesive pleomorphic malignant cells in a strong inflammatory milieu reminiscent of inflammatory malignant fibrous histiocytoma (MFH). Subsequent cervical lymph node biopsy revealed a spindle cell sarcoma predominantly composed of plump spindle and oval neoplastic cells in interweaving fascicles, with sparse inflammatory infiltrates, resembling pleomorphic-storiform type of MFH. However, these tumor cells in the lung and node lesions revealed essentially similar immunohistochemical features that were positive for CD30, EMA, TIA-1, granzyme B, and fascin, but negative for anaplastic lymphoma kinase (ALK), and T- or B-lineage-specific marker. The spindled cells stains diffuse strong positive for smooth muscle actin (SMA), along with vimentin. Further studies showed that the tumor produced large quantities of the proinflammatory cytokines interleukin-2 (IL-2), IL-6, and IL-8, which we believe may contribute to the pathogenesis of sarcomatoid transformation of this tumor, and was associated with the patient’s inflammatory symptoms. To the best of our knowledge, this is the first reported case of sarcomatoid variant of ALK-negative ALCL with null cell phenotype and in situ production of proinflammatory cytokines presenting as multiple nodes and pulmonary involvement. PMID:25197351

  3. Applying STAMP in Accident Analysis

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy; Daouk, Mirna; Dulac, Nicolas; Marais, Karen

    2003-01-01

    Accident models play a critical role in accident investigation and analysis. Most traditional models are based on an underlying chain of events. These models, however, have serious limitations when used for complex, socio-technical systems. Previously, Leveson proposed a new accident model (STAMP) based on system theory. In STAMP, the basic concept is not an event but a constraint. This paper shows how STAMP can be applied to accident analysis using three different views or models of the accident process and proposes a notation for describing this process.

  4. Commercial SNF Accident Release Fractions

    SciTech Connect

    J. Schulz

    2004-11-05

    The purpose of this analysis is to specify and document the total and respirable fractions for radioactive materials that could be potentially released from an accident at the repository involving commercial spent nuclear fuel (SNF) in a dry environment. The total and respirable release fractions are used to support the preclosure licensing basis for the repository. The total release fraction is defined as the fraction of total commercial SNF assembly inventory, typically expressed as an activity inventory (e.g., curies), of a given radionuclide that is released to the environment from a waste form. Radionuclides are released from the inside of breached fuel rods (or pins) and from the detachment of radioactive material (crud) from the outside surfaces of fuel rods and other components of fuel assemblies. The total release fraction accounts for several mechanisms that tend to retain, retard, or diminish the amount of radionuclides that are available for transport to dose receptors or otherwise can be shown to reduce exposure of receptors to radiological releases. The total release fraction includes a fraction of airborne material that is respirable and could result in inhalation doses; this subset of the total release fraction is referred to as the respirable release fraction. Accidents may involve waste forms characterized as: (1) bare unconfined intact fuel assemblies, (2) confined intact fuel assemblies, or (3) canistered failed commercial SNF. Confined intact commercial SNF assemblies at the repository are contained in shipping casks, canisters, or waste packages. Four categories of failed commercial SNF are identified: (1) mechanically and cladding-penetration damaged commercial SNF, (2) consolidated/reconstituted assemblies, (3) fuel rods, pieces, and debris, and (4) nonfuel components. It is assumed that failed commercial SNF is placed into waste packages with a mesh screen at each end (CRWMS M&O 1999). In contrast to bare unconfined fuel assemblies, the

  5. Fatal aviation accidents in Lower Saxony from 1979 to 1996.

    PubMed

    Ast, F W; Kernbach-Wighton, G; Kampmann, H; Koops, E; Püschel, K; Tröger, H D; Kleemann, W J

    2001-06-01

    So far no national or regional studies have been published in Germany regarding the number of fatal aviation accidents and results of autopsy findings. Therefore, we evaluated all fatal aviation accidents occurring in Lower Saxony from 1979 to 1996. A total of 96 aviation accidents occurred in this period involving 73 aeroplanes. The crashes resulted in the death of 154 people ranging in age from 19 to 68 years. The greatest number of victims in a single crash of an aircraft was (n=7). Other types of fatal accidents were crashes of aircraft and helicopter while on the ground (n=5), hot-air balloons (n=2), parachutes (n=10), hang glider accidents (n=5) and the striking of a bystander by a model airplane. Autopsies were performed on 68 of the 154 victims (44.2%), including 39 of the 73 pilots (53.4%). Some of the autopsies yielded findings relevant to the cause of the accident: gunshot wounds, the presence of alcohol or drugs in blood and preexisting diseases. Our findings emphasize the need for autopsy on all aviation accident victims, especially pilots, as this is the only reliable method to uncover all factors contributing to an accident.

  6. Fatal aviation accidents in Lower Saxony from 1979 to 1996.

    PubMed

    Ast, F W; Kernbach-Wighton, G; Kampmann, H; Koops, E; Püschel, K; Tröger, H D; Kleemann, W J

    2001-06-01

    So far no national or regional studies have been published in Germany regarding the number of fatal aviation accidents and results of autopsy findings. Therefore, we evaluated all fatal aviation accidents occurring in Lower Saxony from 1979 to 1996. A total of 96 aviation accidents occurred in this period involving 73 aeroplanes. The crashes resulted in the death of 154 people ranging in age from 19 to 68 years. The greatest number of victims in a single crash of an aircraft was (n=7). Other types of fatal accidents were crashes of aircraft and helicopter while on the ground (n=5), hot-air balloons (n=2), parachutes (n=10), hang glider accidents (n=5) and the striking of a bystander by a model airplane. Autopsies were performed on 68 of the 154 victims (44.2%), including 39 of the 73 pilots (53.4%). Some of the autopsies yielded findings relevant to the cause of the accident: gunshot wounds, the presence of alcohol or drugs in blood and preexisting diseases. Our findings emphasize the need for autopsy on all aviation accident victims, especially pilots, as this is the only reliable method to uncover all factors contributing to an accident. PMID:11348795

  7. The effects of aircraft certification rules on general aviation accidents

    NASA Astrophysics Data System (ADS)

    Anderson, Carolina Lenz

    The purpose of this study was to analyze the frequency of general aviation airplane accidents and accident rates on the basis of aircraft certification to determine whether or not differences in aircraft certification rules had an influence on accidents. In addition, the narrative cause descriptions contained within the accident reports were analyzed to determine whether there were differences in the qualitative data for the different certification categories. The certification categories examined were: Federal Aviation Regulations Part 23, Civil Air Regulations 3, Light Sport Aircraft, and Experimental-Amateur Built. The accident causes examined were those classified as: Loss of Control, Controlled Flight into Terrain, Engine Failure, and Structural Failure. Airworthiness certification categories represent a wide diversity of government oversight. Part 23 rules have evolved from the initial set of simpler design standards and have progressed into a comprehensive and strict set of rules to address the safety issues of the more complex airplanes within the category. Experimental-Amateur Built airplanes have the least amount of government oversight and are the fastest growing segment. The Light Sport Aircraft category is a more recent certification category that utilizes consensus standards in the approval process. Civil Air Regulations 3 airplanes were designed and manufactured under simpler rules but modifying these airplanes has become lengthy and expensive. The study was conducted using a mixed methods methodology which involves both quantitative and qualitative elements. A Chi-Square test was used for a quantitative analysis of the accident frequency among aircraft certification categories. Accident rate analysis of the accidents among aircraft certification categories involved an ANCOVA test. The qualitative component involved the use of text mining techniques for the analysis of the narrative cause descriptions contained within the accident reports. The Chi

  8. [Skateboard and rollerskate accidents].

    PubMed

    Lohmann, M; Petersen, A O; Pedersen, O D

    1990-05-28

    The increasing popularity of skateboards and rollerskates has resulted in an increased number of contacts with the casualty department in Denmark after accidents. As part of the Danish share in the EHLASS project (European Home and Leisure Surveillance System), 120,000 consecutive contacts with the casualty departments were reviewed. Out of these 516 were due to accidents with skateboards and rollerskates (181/335). A total of 194 of these injuries (38%) were fractures and 80% of these were in the upper limbs. Twenty fractures required reposition under general anaesthesia and two required osteosynthesis. Nine patients were admitted for observation for concussion. One patient had sustained rupture of the spleen and splenectomy was necessary. A total of 44 patients were admitted. None of the 516 patients had employed protective equipment on the injured region. Considerable reduction in the number of injuries could probably be produced by employment of suitable protective equipment.

  9. [Drowning accidents in childhood].

    PubMed

    Krandick, G; Mantel, K

    1990-09-30

    This is a report on five boys aged between 1 and 5 years who, after prolonged submersion in cold water, were treated at our department. On being taken out of the water, all the patients were clinically dead. After 1- to 3-hour successful cardiopulmonary resuscitation, with a rectal temperature of about 27 degrees C, they were rewarmed at a rate of 1 degree/hour. Two patients died within a few hours after the accident. One patient survived with an apallic syndrome, 2 children survived with no sequelae. In the event of a water-related accident associated with hypothermia, we consider suitable resuscitation to have preference over rewarming measures. The most important treatment guidelines and prognostic factors are discussed.

  10. Farm accidents in children.

    PubMed

    Cogbill, T H; Busch, H M; Stiers, G R

    1985-10-01

    During a 6 1/2 year period, 105 children were admitted to the hospital as the result of trauma that occurred on farms. The mechanism of injury was animal related in 42 (40%), tractor or wagon accident in 28 (26%), farm machinery in 21 (20%), fall from farm building in six (6%), and miscellaneous in eight (8%). Injury Severity Score was calculated for each patient. An Injury Severity Score of greater than or equal to 25 was determined for 11 children (11%). Life-threatening injuries, therefore, are frequently the result of childhood activities that take place in agricultural environments. The most common injuries were orthopedic, neurologic, thoracoabdominal, and maxillofacial. There was one death in the series, and only one survivor sustained major long-term disability. Such injuries are managed with optimal outcome in a regional trauma center. Educational programs with an emphasis on prevention and safety measures may reduce the incidence of farm accidents. PMID:4047799

  11. Bus accident analysis of routes with/without bus priority.

    PubMed

    Goh, Kelvin Chun Keong; Currie, Graham; Sarvi, Majid; Logan, David

    2014-04-01

    This paper summarises findings on road safety performance and bus-involved accidents in Melbourne along roads where bus priority measures had been applied. Results from an empirical analysis of the accident types revealed significant reduction in the proportion of accidents involving buses hitting stationary objects and vehicles, which suggests the effect of bus priority in addressing manoeuvrability issues for buses. A mixed-effects negative binomial (MENB) regression and back-propagation neural network (BPNN) modelling of bus accidents considering wider influences on accident rates at a route section level also revealed significant safety benefits when bus priority is provided. Sensitivity analyses done on the BPNN model showed general agreement in the predicted accident frequency between both models. The slightly better performance recorded by the MENB model results suggests merits in adopting a mixed effects modelling approach for accident count prediction in practice given its capability to account for unobserved location and time-specific factors. A major implication of this research is that bus priority in Melbourne's context acts to improve road safety and should be a major consideration for road management agencies when implementing bus priority and road schemes.

  12. Assessment of possible consequences of a hypothetical reactivity accident associated with a {open_quotes}Topaz-2{close_quotes} spacecraft reactor entering water

    SciTech Connect

    Glushkov, E.S.; Ermoshin, M.Yu.; Ponomarev-Stepnoi; Skorlygin, V.V.

    1994-12-01

    An accident analysis for a Russian Topaz-2 nuclear reactor is summarized. The accident scenario involves emergency return from orbit, severe damage to reactor structural elements, and subsequent falling of the reactor core into the ocean. The thermionic converter reactor, used in spacecraft, has a large neutron leakage which decreases when water enters the inner core cavity. Preliminary results of numerical modeling, summarized in the article, show that the possible consequences of the hypothetical accidental submersion are limited. 8 refs., 2 figs., 2 tabs.

  13. Extension of ship accident analysis to multiple-package shipments

    SciTech Connect

    Mills, G.S.; Neuhauser, K.S.

    1997-11-01

    Severe ship accidents and the probability of radioactive material release from spent reactor fuel casks were investigated previously. Other forms of RAM, e.g., plutonium oxide powder, may be shipped in large numbers of packagings rather than in one to a few casks. These smaller, more numerous packagings are typically placed in ISO containers for ease of handling, and several ISO containers may be placed in one of several holds of a cargo ship. In such cases, the size of a radioactive release resulting from a severe collision with another ship is determined not by the likelihood of compromising a single, robust package but by the probability that a certain fraction of 10`s or 100`s of individual packagings is compromised. The previous analysis involved a statistical estimation of the frequency of accidents which would result in damage to a cask located in one of seven cargo holds in a collision with another ship. The results were obtained in the form of probabilities (frequencies) of accidents of increasing severity and of release fractions for each level of severity. This paper describes an extension of the same general method in which the multiple packages are assumed to be compacted by an intruding ship`s bow until there is no free space in the hold. At such a point, the remaining energy of the colliding ship is assumed to be dissipated by progressively crushing the RAM packagings and the probability of a particular fraction of package failures is estimated by adaptation of the statistical method used previously. The parameters of a common, well characterized packaging, the 6M with 2R inner containment vessel, were employed as an illustrative example of this analysis method. However, the method is readily applicable to other packagings for which crush strengths have been measured or can be estimated with satisfactory confidence.

  14. Studies on BVD involving establishment of sentinel calves and assessment of herd immunity in a large dairy farm in Saudi Arabia.

    PubMed

    Abu Elzein, Eltayb; Alkhalyifa, Mofeed

    2012-03-01

    Little information is published, so far, regarding bovine viral diarrhea (BVD) in Saudi Arabia and the Gulf region. This study is the first of its kind in the country. Its aim was to explore the BVD situation in a large dairy farm, which has been experiencing reproduction problems suggestive of BVD virus infection, albeit the practice of routine vaccination. The study took two pathways; the first involved establishment of a cohort of sentinel calves so as: (a) to note the BVD virus activity in the farm by following the time lapse and pattern for waning of the maternally derived antibodies and detection of any subsequent seroconversion and (b) to look for any clinical signs suggestive of BVD virus infection in these calves. The second pathway was to assess the level of herd immunity in the different age groups of lactating cows and maiden heifers. The obtained results were discussed, and control strategies were outlined.

  15. The Fukushima accident was preventable.

    PubMed

    Synolakis, Costas; Kânoğlu, Utku

    2015-10-28

    The 11 March 2011 tsunami was probably the fourth largest in the past 100 years and killed over 15 000 people. The magnitude of the design tsunami triggering earthquake affecting this region of Japan had been grossly underestimated, and the tsunami hit the Fukushima Dai-ichi nuclear power plant (NPP), causing the third most severe accident in an NPP ever. Interestingly, while the Onagawa NPP was also hit by a tsunami of approximately the same height as Dai-ichi, it survived the event 'remarkably undamaged'. We explain what has been referred to as the cascade of engineering and regulatory failures that led to the Fukushima disaster. One, insufficient attention had been given to evidence of large tsunamis inundating the region earlier, to Japanese research suggestive that large earthquakes could occur anywhere along a subduction zone, and to new research on mega-thrusts since Boxing Day 2004. Two, there were unexplainably different design conditions for NPPs at close distances from each other. Three, the hazard analysis to calculate the maximum probable tsunami at Dai-ichi appeared to have had methodological mistakes, which almost nobody experienced in tsunami engineering would have made. Four, there were substantial inadequacies in the Japan nuclear regulatory structure. The Fukushima accident was preventable, if international best practices and standards had been followed, if there had been international reviews, and had common sense prevailed in the interpretation of pre-existing geological and hydrodynamic findings. Formal standards are needed for evaluating the tsunami vulnerability of NPPs, for specific training of engineers and scientists who perform tsunami computations for emergency preparedness or critical facilities, as well as for regulators who review safety studies.

  16. The Fukushima accident was preventable.

    PubMed

    Synolakis, Costas; Kânoğlu, Utku

    2015-10-28

    The 11 March 2011 tsunami was probably the fourth largest in the past 100 years and killed over 15 000 people. The magnitude of the design tsunami triggering earthquake affecting this region of Japan had been grossly underestimated, and the tsunami hit the Fukushima Dai-ichi nuclear power plant (NPP), causing the third most severe accident in an NPP ever. Interestingly, while the Onagawa NPP was also hit by a tsunami of approximately the same height as Dai-ichi, it survived the event 'remarkably undamaged'. We explain what has been referred to as the cascade of engineering and regulatory failures that led to the Fukushima disaster. One, insufficient attention had been given to evidence of large tsunamis inundating the region earlier, to Japanese research suggestive that large earthquakes could occur anywhere along a subduction zone, and to new research on mega-thrusts since Boxing Day 2004. Two, there were unexplainably different design conditions for NPPs at close distances from each other. Three, the hazard analysis to calculate the maximum probable tsunami at Dai-ichi appeared to have had methodological mistakes, which almost nobody experienced in tsunami engineering would have made. Four, there were substantial inadequacies in the Japan nuclear regulatory structure. The Fukushima accident was preventable, if international best practices and standards had been followed, if there had been international reviews, and had common sense prevailed in the interpretation of pre-existing geological and hydrodynamic findings. Formal standards are needed for evaluating the tsunami vulnerability of NPPs, for specific training of engineers and scientists who perform tsunami computations for emergency preparedness or critical facilities, as well as for regulators who review safety studies. PMID:26392611

  17. Comprehensive analysis of single- and multi-vehicle large truck at-fault crashes on rural and urban roadways in Alabama.

    PubMed

    Islam, Samantha; Jones, Steven L; Dye, Daniel

    2014-06-01

    The research described in this paper analyzed injury severities at a disaggregate level for single-vehicle (SV) and multi-vehicle (MV) large truck at-fault accidents for rural and urban locations in Alabama. Given the occurrence of a crash, four separate random parameter logit models of injury severity (with possible outcomes of major, minor, and possible or no injury) were estimated. The models identified different sets of factors that can lead to effective policy decisions aimed at reducing large truck-at-fault accidents for respective locations. The results of the study clearly indicated that there are differences between the influences of a variety of variables on the injury severities resulting from urban vs. rural SV and MV large truck at-fault accidents. The results showed that some variables were significant only in one type of accident model (SV or MV) but not in the other accident model. Again, some variables were found to be significant in one location (rural or urban) but not in other locations. The study also identified important factors that significantly impact the injury severity resulting from SV and MV large truck at-fault accidents in urban and rural locations based on the estimated values of average direct pseudo-elasticity. A careful study of the results of this study will help policy makers and transportation agencies identify location specific recommendations to increase safety awareness related to large truck involved accidents and to improve overall highway safety.

  18. Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

    PubMed

    Colomba, A; Courilleau, D; Ramel, D; Billadeau, D D; Espinos, E; Delsol, G; Payrastre, B; Gaits-Iacovoni, F

    2008-04-24

    The majority of anaplastic large cell lymphomas (ALCLs) express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, which is oncogenic due to its constitutive tyrosine kinase activity. Transformation by NPM-ALK not only increases proliferation, but also modifies cell shape and motility in both lymphoid and fibroblastic cells. We report that the Rac1 GTPase, a known cytoskeletal regulator, is activated by NPM-ALK in ALCL cell lines (Karpas 299 and Cost) and transfected cells (lymphoid Ba/F3 cells, NIH-3T3 fibroblasts). We have identified Vav3 as one of the exchange factors involved in Rac1 activation. Stimulation of Vav3 and Rac1 by NPM-ALK is under the control of Src kinases. It involves formation of a signaling complex between NPM-ALK, pp60(c-src), Lyn and Vav3, in which Vav3 associates with tyrosine 343 of NPM-ALK via its SH2 domain. Moreover, Vav3 is phosphorylated in NPM-ALK positive biopsies from patients suffering from ALCL, demonstrating the pathological relevance of this observation. The use of Vav3-specific shRNA and a dominant negative Rac1 mutant demonstrates the central role of GTPases in NPM-ALK elicited motility and invasion.

  19. Primary diffuse large B-cell lymphoma of the dura with skull and scalp involvement: A case report and brief review of the literature

    PubMed Central

    LV, ZHONG-WEN; CHENG, KAI-LIANG; TIAN, HONG-JI; HAN, XUE-MEI

    2016-01-01

    Primary dural lymphoma (PDL) refers to a lymphoma with epidural or subdural involvement and is a rare subtype of primary central nervous system lymphoma. Diffuse large B-cell lymphoma (DLBCL) presenting as PDL is extremely rare. The present study reports a case of PDL with skull and scalp involvement in a 56-year-old man. Magnetic resonance imaging (MRI) revealed that the tumor was located under the right parietal inner plate and was attached to the dura mater. Following contrast-enhanced MRI, markedly enhanced tumor signals were observed, and mild homogeneous enhancement was observed in the diploë and soft tissues under the scalp, near the parietal bone. Under general anesthesia, the patient underwent craniotomy and tumor resection. The postoperative pathological diagnosis was DLBCL. Tumors were additionally identified inside the skull and subcutaneous tissues. The patient was administered chemotherapy postoperatively, and the prognosis subsequent to the 4-year follow-up was favorable. Primary malignant lymphoma should be considered in the differential diagnosis of scalp masses and meningeal lesions. Early diagnosis and individualized treatment is closely associated with a favorable outcome. PMID:27284359

  20. A Reasoned Action Model of Male Client Involvement in Commercial Sex Work in Kibera, A Large Informal Settlement in Nairobi, Kenya

    PubMed Central

    Roth, Eric Abella; Ngugi, Elizabeth; Benoit, Cecilia; Jansson, Mikael; Hallgrimsdottir, Helga

    2015-01-01

    Male clients of female sex workers (FSWs) are epidemiologically important because they can form bridge groups linking high- and low-risk subpopulations. However, because male clients are hard to locate, they are not frequently studied. Recent research emphasizes searching for high-risk behavior groups in locales where new sexual partnerships form and the threat of HIV transmission is high. Sub-Saharan Africa public drinking venues satisfy these criteria. Accordingly, this study developed and implemented a rapid assessment methodology to survey men in bars throughout the large informal settlement of Kibera, Nairobi, Kenya, with the goal of delineating cultural and economic rationales associated with male participation in commercial sex. The study sample consisted of 220 male patrons of 110 bars located throughout Kibera’s 11 communities. Logistic regression analysis incorporating a modified Reasoned Action Model indicated that a social norm condoning commercial sex among male peers and the cultural belief that men should practice sex before marriage support commercial sex involvement. Conversely, lacking money to drink and/or pay for sexual services were barriers to male commercial sex involvement. Results are interpreted in light of possible harm reduction programs focusing on FSWs’ male clients. PMID:26778847

  1. Chemical Stockpile Disposal Program rapid accident assessment

    SciTech Connect

    Chester, C.V.

    1990-08-01

    This report develops a scheme for the rapid assessment of a release of toxic chemicals resulting from an accident in one of the most chemical weapon demilitarization plants or storage areas. The system uses such inputs as chemical and pressure sensors monitoring the plant and reports of accidents radioed to the Emergency Operations Center by work parties or monitoring personnel. A size of release can be estimated from previous calculations done in the risk analysis, from back calculation from an open-air chemical sensor measurement, or from an estimated percentage of the inventory of agent at the location of the release. Potential consequences of the estimated release are calculated from real-time meteorological data, surrounding population data, and properties of the agent. In addition to the estimated casualties, area coverage and no-death contours vs time would be calculated. Accidents are assigned to one of four categories: community emergencies, which are involve a threat to off-site personnel; on-post emergencies, which involve a threat only to on-site personnel; advisory, which involves a potential for threat to on-site personnel; and chemical occurrence, which can produce an abnormal operating condition for the plant but no immediate threat to on-site personnel. 9 refs., 20 tabs.

  2. ATMOSPHERIC MODELING IN SUPPORT OF A ROADWAY ACCIDENT

    SciTech Connect

    Buckley, R.; Hunter, C.

    2010-10-21

    The United States Forest Service-Savannah River (USFS) routinely performs prescribed fires at the Savannah River Site (SRS), a Department of Energy (DOE) facility located in southwest South Carolina. This facility covers {approx}800 square kilometers and is mainly wooded except for scattered industrial areas containing facilities used in managing nuclear materials for national defense and waste processing. Prescribed fires of forest undergrowth are necessary to reduce the risk of inadvertent wild fires which have the potential to destroy large areas and threaten nuclear facility operations. This paper discusses meteorological observations and numerical model simulations from a period in early 2002 of an incident involving an early-morning multicar accident caused by poor visibility along a major roadway on the northern border of the SRS. At the time of the accident, it was not clear if the limited visibility was due solely to fog or whether smoke from a prescribed burn conducted the previous day just to the northwest of the crash site had contributed to the visibility. Through use of available meteorological information and detailed modeling, it was determined that the primary reason for the low visibility on this night was fog induced by meteorological conditions.

  3. Recommendations for Injury Prevention in Transport Aviation Accidents

    NASA Technical Reports Server (NTRS)

    Grierson, Anita E.; Jones, Lisa E.

    2001-01-01

    In 1996, a national objective was established to reduce the rate of fatal accidents in aviation. To assist in determining the best methods for improving aircraft crash survivability, a combined approach was used involving database research and the examination of case studies of transport aviation accidents. The results of the study include recommendations for maintaining occupiable space, enhancing occupant restraint, managing energy transferred to the occupant, improving egress, and increasing post-crash survival.

  4. 1976 Hanford americium-exposure incident: accident description

    SciTech Connect

    McMurray, B J

    1982-01-01

    An accident is described, involving the explosion of an ion-exchange column containing about 100 g of /sup 241/Am. A chemical operator was injured in this accident, receiving acid burns and superficial cuts on the upper part of his body. From 1 to 5 curies of /sup 241/Am is estimated to have been deposited on the injured worker and on his clothing.

  5. Studies on the Coordination of Ribosomal Protein Assembly Events Involved in Processing and Stabilization of Yeast Early Large Ribosomal Subunit Precursors

    PubMed Central

    Sauert, Martina; Martín-Marcos, Pilar; Tamame, Mercedes; Tschochner, Herbert; Griesenbeck, Joachim; Milkereit, Philipp

    2015-01-01

    Cellular production of ribosomes involves the formation of highly defined interactions between ribosomal proteins (r-proteins) and ribosomal RNAs (rRNAs). Moreover in eukaryotic cells, efficient ribosome maturation requires the transient association of a large number of ribosome biogenesis factors (RBFs) with newly forming ribosomal subunits. Here, we investigated how r-protein assembly events in the large ribosomal subunit (LSU) rRNA domain II are coordinated with each other and with the association of RBFs in early LSU precursors of the yeast Saccharomyces cerevisiae. Specific effects on the pre-ribosomal association of RBFs could be observed in yeast mutants blocked in LSU rRNA domain II assembly. Moreover, formation of a cluster of r-proteins was identified as a downstream event in LSU rRNA domain II assembly. We analyzed in more detail the functional relevance of eukaryote specific bridges established by this r-protein cluster between LSU rRNA domain II and VI and discuss how they can support the stabilization and efficient processing of yeast early LSU precursor RNAs. PMID:26642313

  6. Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type.

    PubMed

    Yamane, Hiromichi; Ohsawa, Masahiro; Shiote, Yasuhiro; Umemura, Shigeki; Suwaki, Toshimitsu; Shirakawa, Atsuko; Kamei, Haruhito; Takigawa, Nagio; Kiura, Katsuyuki

    2011-12-01

    We describe a case of pulmonary diffuse large B-cell lymphoma (DLBCL), which was thought to arise from extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 68-year-old woman presented with a 2-month history of cough and bloody sputum. The chest X-ray and computed tomography revealed a mass with cavitation in the right lower lobe. Transbronchial biopsy specimens revealed a granulomatous infiltration without malignant cells. However, diagnosis of MALT lymphoma was established from gastric biopsy specimen. Subsequently, a right lower lobectomy was performed because of hemoptysis. Examination of the resected specimen revealed a diffuse large B-cell lymphoma, which was considered to have transformed from MALT lymphoma, because both lung and stomach lesions had the chromosomal translocation t(11;18)(q21;q21) in common. In addition, there were no nodules, masses, alveolar or interstitial infiltrates in the lung fields, which are usually observed in the case of marginal zone B-cell lymphoma of bronchial mucosa-associated lymphoid tissue. These findings indicate that involvement of DLBCL have to be considered in patients with MALT lymphoma and cavitary lesion of the lung. PMID:26189744

  7. [Chernobyl nuclear power plant accident and Tokaimura criticality accident].

    PubMed

    Takada, Jun

    2012-03-01

    It is clear from inspection of historical incidents that the scale of disasters in a nuclear power plant accident is quite low level overwhelmingly compared with a nuclear explosion in nuclear war. Two cities of Hiroshima and Nagasaki were destroyed by nuclear blast with about 20 kt TNT equivalent and then approximately 100,000 people have died respectively. On the other hand, the number of acute death is 30 in the Chernobyl nuclear reactor accident. In this chapter, we review health hazards and doses in two historical nuclear incidents of Chernobyl and Tokaimura criticality accident and then understand the feature of the radiation accident in peaceful utilization of nuclear power.

  8. Dynamics Modeling and Simulation of Large Transport Airplanes in Upset Conditions

    NASA Technical Reports Server (NTRS)

    Foster, John V.; Cunningham, Kevin; Fremaux, Charles M.; Shah, Gautam H.; Stewart, Eric C.; Rivers, Robert A.; Wilborn, James E.; Gato, William

    2005-01-01

    As part of NASA's Aviation Safety and Security Program, research has been in progress to develop aerodynamic modeling methods for simulations that accurately predict the flight dynamics characteristics of large transport airplanes in upset conditions. The motivation for this research stems from the recognition that simulation is a vital tool for addressing loss-of-control accidents, including applications to pilot training, accident reconstruction, and advanced control system analysis. The ultimate goal of this effort is to contribute to the reduction of the fatal accident rate due to loss-of-control. Research activities have involved accident analyses, wind tunnel testing, and piloted simulation. Results have shown that significant improvements in simulation fidelity for upset conditions, compared to current training simulations, can be achieved using state-of-the-art wind tunnel testing and aerodynamic modeling methods. This paper provides a summary of research completed to date and includes discussion on key technical results, lessons learned, and future research needs.

  9. [Radiation emergency medical preparedness in Japan--lessons learned from the Fukushima accident].

    PubMed

    Akashi, Makoto; Tominaga, Takako; Takabatake, Takashi; Michikawa, Yuichi; Hachiya, Misao

    2012-03-01

    Although radiation exposure accidents fortunately occur only rarely, potential sources for exposure accidents can be found anywhere. When persons are accidentally exposed to radiation, physicians may be involved in their assessment and care; of course, their early diagnosis and dose assessment are crucial. After the criticality accident at Tokaimura in 1999, the system of radiation emergency medical preparedness has been further strengthened for nuclear facilities in Japan. In the revised system, hospitals involved were classified into three levels, depending on their locations and capabilities. The Great East Japan Earthquake attacked the Pacific coast area of eastern Japan on 11 March 2011. This earthquake and tsunami caused serious damage to the nuclear power plants of Tokyo Electric Power Co.(TEPCO) in Fukushima Prefecture; a large amount of radionuclides such as iodine and cesium were released into the environment. Since the revised system was focused on treatment of heavily exposed patients and knowledge on radiation was not enough for medical staff, many problems were raised at hospitals and fire departments in this disaster.

  10. Aircraft accident survivors as witnesses.

    PubMed

    Dodge, R E

    1983-02-01

    This is a study of the reliability of aircrash survivors as witnesses. Some of their statements are compared to known facts at the time of the crash, including the time of the accident and the weather conditions. Other facts are compared between the survivors, such as the mood of the passengers immediately post-crash. The KLM-Pan Am accident in the Canary Islands is used as the study accident. A suggestion for future use of survivors' statements is tendered.

  11. Longitudinal review of state-level accident statistics for carriers of interstate freight

    SciTech Connect

    Saricks, C.; Kvitek, T.

    1994-03-01

    State-level accident rates by mode of freight transport have been developed and refined for application to the US Department of Energy`s (DOE`s) environmental mitigation program, which may involve large-quantity shipments of hazardous and mixed wastes from DOE facilities. These rates reflect multi-year data for interstate-registered highway earners, American Association of Railroads member carriers, and coastal and internal waterway barge traffic. Adjustments have been made to account for the share of highway combination-truck traffic actually attributable to interstate-registered carriers and for duplicate or otherwise inaccurate entries in the public-use accident data files used. State-to-state variation in rates is discussed, as is the stability of rates over time. Computed highway rates have been verified with actual carriers of high- and low-level nuclear materials, and the most recent truck accident data have been used, to ensure that the results are of the correct order of magnitude. Study conclusions suggest that DOE use the computed rates for the three modes until (1) improved estimation techniques for highway combination-truck miles by state become available; (2) continued evolution of the railroad industry significantly increases the consolidation of interstate rail traffic onto fewer high-capacity trunk lines; or (3) a large-scale off-site waste shipment campaign is imminent.

  12. Involvement of large-conductance Ca(2+) -activated K(+) channels in both nitric oxide and endothelium-derived hyperpolarization-type relaxation in human penile small arteries.

    PubMed

    Király, István; Pataricza, János; Bajory, Zoltán; Simonsen, Ulf; Varro, András; Papp, Julius Gy; Pajor, Lászlo; Kun, Attila

    2013-07-01

    Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is little information on the role of BKC a channels located in penile vascular smooth muscle. This study was designed to investigate the involvement of BKC a channels in endothelium-dependent and endothelium-independent relaxation of human intracavernous penile arteries. In human intracavernous arteries obtained in connection with transsexual operations, change in isometric force was recorded in microvascular myographs, and endothelium-dependent [nitric oxide (NO) and endothelium-derived hyperpolarization (EDH)-type] and endothelium-independent (NO-donor) relaxations were measured in contracted arteries. In penile small arteries contracted with phenylephrine, acetylcholine evoked NO- and EDH-type relaxations, which were sensitive to iberiotoxin (IbTX), a selective blocker of BKC a channels. Iberiotoxin also inhibited relaxations induced by a NO-donor, sodium nitroprusside. NS11021, a selective opener of BKC a channels, evoked pronounced relaxations that were inhibited in the presence of IbTX. NS13558, a BKC a -inactive analogue of NS11021, failed to relax human penile small arteries. Our results show that BKC a channels are involved in both NO- and EDH-type relaxation of intracavernous penile arteries obtained from healthy men. The effect of a selective opener of BKC a channels also suggests that direct activation of the channel may be an advantageous approach for treatment of impaired endothelium-dependent relaxation often associated with erectile dysfunction.

  13. Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy.

    PubMed

    Maciocia, Paul; Badat, Mohsin; Cheesman, Simon; D'Sa, Shirley; Joshi, Rahul; Lambert, Jonathan; Mohamedbhai, Sajir; Pule, Martin; Linch, David; Ardeshna, Kirit

    2016-02-01

    Diffuse large B-cell lymphoma with secondary involvement of the central nervous system (SCNS-DLBCL) is a rare condition carrying a poor prognosis. No optimal therapeutic regimen has been identified. We retrospectively analysed 23 patients with SCNS-DLBCL treated with R-IDARAM (rituximab 375 mg/m(2) IV day 1; methotrexate 12·5 mg by intrathecal injection day 1; idarubicin 10 mg/m(2) /day IV days 1 and 2; dexamethasone 100 mg/day IV infusion over 12 h days 1-3; cytosine arabinoside 1000 mg/m(2) /day IV over 1 h days 1 and 2; and methotrexate 2000 mg/m(2) IV over 2 h day 3. Ten out of 23 (44%) patients had CNS involvement at initial presentation ('new disease'), 10/23 (44%) had relapsed disease and 3/23 (13%) had primary refractory disease. 14/23 (61%) of patients responded - 6 (26%) complete response, 8 (35%) partial response. Grade 3-4 haematological toxicity was seen in all cycles, with no grade 3-4 or long-term neurological toxicity. Median follow-up for surviving patients was 49 months. At 2 years, estimated progression-free survival (PFS) was 39% and overall survival (OS) was 52%. Encouraging outcomes were reported in patients with new disease, with 5-year estimated PFS of 50% and OS 75%. R-IDARAM is a well-tolerated regimen with encouraging efficacy in patients with SCNS-DLBCL, although patients with relapsed or refractory disease continue to fare poorly. PMID:26684148

  14. Analysis of Occupational Accident Fatalities and Injuries Among Male Group in Iran Between 2008 and 2012

    PubMed Central

    Alizadeh, Seyed Shamseddin; Mortazavi, Seyed Bagher; Sepehri, Mohammad Mehdi

    2015-01-01

    Background: Because of occupational accidents, permanent disabilities and deaths occur and economic and workday losses emerge. Objectives: The purpose of the present study was to investigate the factors responsible for occupational accidents occurred in Iran. Patients and Methods: The current study analyzed 1464 occupational accidents recorded by the Ministry of Labor and Social Affairs’ offices in Iran during 2008 - 2012. At first, general understanding of accidents was obtained using descriptive statistics. Afterwards, the chi-square test and Cramer’s V statistic (Vc) were used to determine the association between factors influencing the type of injury as occupational accident outcomes. Results: There was no significant association between marital status and time of day with the type of injury. However, activity sector, cause of accident, victim’s education, age of victim and victim’s experience were significantly associated with the type of injury. Conclusions: Successful accident prevention relies largely on knowledge about the causes of accidents. In any accident control activity, particularly in occupational accidents, correctly identifying high-risk groups and factors influencing accidents is the key to successful interventions. Results of this study can cause to increase accident awareness and enable workplace’s management to select and prioritize problem areas and safety system weakness in workplaces. PMID:26568848

  15. 36 CFR 1004.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Report of motor vehicle... SAFETY § 1004.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an... by this section do not relieve the operator and occupants of a motor vehicle involved in an...

  16. 36 CFR 1004.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Report of motor vehicle... SAFETY § 1004.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an... by this section do not relieve the operator and occupants of a motor vehicle involved in an...

  17. 36 CFR 1004.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Report of motor vehicle... SAFETY § 1004.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an... by this section do not relieve the operator and occupants of a motor vehicle involved in an...

  18. 36 CFR 1004.4 - Report of motor vehicle accident.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Report of motor vehicle... SAFETY § 1004.4 Report of motor vehicle accident. (a) The operator of a motor vehicle involved in an... by this section do not relieve the operator and occupants of a motor vehicle involved in an...

  19. [Risk-taking behavior and accidents in adolescence in developed countries].

    PubMed

    Tursz, A; Courtecuisse, V; Jeanneret, O; Sand, A

    1986-01-01

    Injuries due to accidents are the primary cause of fatalities among adolescents. Between the ages of 10 and 19, mortality caused by accidents augments significantly, and there is an excess of male mortality, increasing with age. This mortality has remained virtually unchanged over the past 25 years, except for a small narrowing of rate differences by sex. Traffic accidents, particularly those involving motorcycles, are the leading cause of accident fatalities. Though not easily assessed, morbidity due to accidents is probably very high, especially among males. Sports accidents are the most frequent. Adolescents appear to be particularly exposed to some risks, but also tend to be careless about safety. Risk-taking is a source of rewards: pleasure, self-affirmation, sense of independence; but it is described by some authors as self-destructiveness, death from accidents reflecting suicidal tendencies. Paradoxical results of prevention have been observed in this age group.

  20. Presence of a Large β(1-3)Glucan Linked to Chitin at the Saccharomyces cerevisiae Mother-Bud Neck Suggests Involvement in Localized Growth Control

    PubMed Central

    Blanco, Noelia; Arroyo, Javier

    2012-01-01

    Previous results suggested that the chitin ring present at the yeast mother-bud neck, which is linked specifically to the nonreducing ends of β(1-3)glucan, may help to suppress cell wall growth at the neck by competing with β(1-6)glucan and thereby with mannoproteins for their attachment to the same sites. Here we explored whether the linkage of chitin to β(1-3)glucan may also prevent the remodeling of this polysaccharide that would be necessary for cell wall growth. By a novel mild procedure, β(1-3)glucan was isolated from cell walls, solubilized by carboxymethylation, and fractionated by size exclusion chromatography, giving rise to a very high-molecular-weight peak and to highly polydisperse material. The latter material, soluble in alkali, may correspond to glucan being remodeled, whereas the large-size fraction would be the final cross-linked structural product. In fact, the β(1-3)glucan of buds, where growth occurs, is solubilized by alkali. A gas1 mutant with an expected defect in glucan elongation showed a large increase in the polydisperse fraction. By a procedure involving sodium hydroxide treatment, carboxymethylation, fractionation by affinity chromatography on wheat germ agglutinin-agarose, and fractionation by size chromatography on Sephacryl columns, it was shown that the β(1-3)glucan attached to chitin consists mostly of high-molecular-weight material. Therefore, it appears that linkage to chitin results in a polysaccharide that cannot be further remodeled and does not contribute to growth at the neck. In the course of these experiments, the new finding was made that part of the chitin forms a noncovalent complex with β(1-3)glucan. PMID:22366124

  1. Presence of a large β(1-3)glucan linked to chitin at the Saccharomyces cerevisiae mother-bud neck suggests involvement in localized growth control.

    PubMed

    Cabib, Enrico; Blanco, Noelia; Arroyo, Javier

    2012-04-01

    Previous results suggested that the chitin ring present at the yeast mother-bud neck, which is linked specifically to the nonreducing ends of β(1-3)glucan, may help to suppress cell wall growth at the neck by competing with β(1-6)glucan and thereby with mannoproteins for their attachment to the same sites. Here we explored whether the linkage of chitin to β(1-3)glucan may also prevent the remodeling of this polysaccharide that would be necessary for cell wall growth. By a novel mild procedure, β(1-3)glucan was isolated from cell walls, solubilized by carboxymethylation, and fractionated by size exclusion chromatography, giving rise to a very high-molecular-weight peak and to highly polydisperse material. The latter material, soluble in alkali, may correspond to glucan being remodeled, whereas the large-size fraction would be the final cross-linked structural product. In fact, the β(1-3)glucan of buds, where growth occurs, is solubilized by alkali. A gas1 mutant with an expected defect in glucan elongation showed a large increase in the polydisperse fraction. By a procedure involving sodium hydroxide treatment, carboxymethylation, fractionation by affinity chromatography on wheat germ agglutinin-agarose, and fractionation by size chromatography on Sephacryl columns, it was shown that the β(1-3)glucan attached to chitin consists mostly of high-molecular-weight material. Therefore, it appears that linkage to chitin results in a polysaccharide that cannot be further remodeled and does not contribute to growth at the neck. In the course of these experiments, the new finding was made that part of the chitin forms a noncovalent complex with β(1-3)glucan.

  2. Rear-end accident victims. Importance of understanding the accident.

    PubMed Central

    Sehmer, J. M.

    1993-01-01

    Family physicians regularly treat victims of rear-end vehicle accidents. This article describes how taking a detailed history of the accident and understanding the significance of the physical events is helpful in understanding and anticipating patients' morbidity and clinical course. Eight questions to ask patients are suggested to help physicians understand the severity of injury. PMID:8495140

  3. Radiation accident grips Goiania

    SciTech Connect

    Roberts, L.

    1987-11-20

    On 13 September two young scavengers in Goiania, Brazil, removed a stainless steel cylinder from a cancer therapy machine in an abandoned clinic, touching off a radiation accident second only to Chernobyl in its severity. On 18 September they sold the cylinder, the size of a 1-gallon paint can, to a scrap dealer for $25. At the junk yard an employee dismantled the cylinder and pried open the platinum capsule inside to reveal a glowing blue salt-like substance - 1400 curies of cesium-137. Fascinated by the luminescent powder, several people took it home with them. Some children reportedly rubbed in on their bodies like carnival glitter - an eerie image of how wrong things can go when vigilance over radioactive materials lapses. In all, 244 people in Goiania, a city of 1 million in central Brazil, were contaminated. The eventual toll, in terms of cancer or genetic defects, cannot yet be estimated. Parts of the city are cordoned off as radiation teams continue washing down buildings and scooping up radioactive soil. The government is also grappling with the political fallout from the accident.

  4. Spatio-temporal patterns of hazards and their use in risk assessment and mitigation. Case study of road accidents in Romania

    NASA Astrophysics Data System (ADS)

    Catalin Stanga, Iulian

    2013-04-01

    the spatial or temporal clustering of crash accidents. Since the 1990's, Geographical Informational Systems (GIS) became a very important tool for traffic and road safety management, allowing not only the spatial and multifactorial analysis, but also graphical and non-graphical outputs. The current paper presents an accessible GIS methodology to study the spatio-temporal pattern of injury related road accidents, to identify the high density accidents zones, to make a cluster analysis, to create multicriterial typologies, to identify spatial and temporal similarities and to explain them. In this purpose, a Geographical Information System was created, allowing a complex analysis that involves not only the events, but also a large set of interrelated and spatially linked attributes. The GIS includes the accidents as georeferenced point elements with a spatially linked attribute database: identification information (date, location details); accident type; main, secondary and aggravating causes; data about driver; vehicle information; consequences (damages, injured peoples and fatalities). Each attribute has its own number code that allows both the statistical analysis and the spatial interrogation. The database includes those road accidents that led to physical injuries and loss of human lives between 2007 and 2012 and the spatial analysis was realized using TNTmips 7.3 software facilities. Data aggregation and processing allowed creating the spatial pattern of injury related road accidents through Kernel density estimation at three different levels (national - Romania; county level - Iasi County; local level - Iasi town). Spider graphs were used to create the temporal pattern or road accidents at three levels (daily, weekly and monthly) directly related to their causes. Moreover the spatial and temporal database relates the natural hazards (glazed frost, fog, and blizzard) with the human made ones, giving the opportunity to evaluate the nature of uncertainties in risk

  5. Spatio-temporal patterns of hazards and their use in risk assessment and mitigation. Case study of road accidents in Romania

    NASA Astrophysics Data System (ADS)

    Catalin Stanga, Iulian

    2013-04-01

    the spatial or temporal clustering of crash accidents. Since the 1990's, Geographical Informational Systems (GIS) became a very important tool for traffic and road safety management, allowing not only the spatial and multifactorial analysis, but also graphical and non-graphical outputs. The current paper presents an accessible GIS methodology to study the spatio-temporal pattern of injury related road accidents, to identify the high density accidents zones, to make a cluster analysis, to create multicriterial typologies, to identify spatial and temporal similarities and to explain them. In this purpose, a Geographical Information System was created, allowing a complex analysis that involves not only the events, but also a large set of interrelated and spatially linked attributes. The GIS includes the accidents as georeferenced point elements with a spatially linked attribute database: identification information (date, location details); accident type; main, secondary and aggravating causes; data about driver; vehicle information; consequences (damages, injured peoples and fatalities). Each attribute has its own number code that allows both the statistical analysis and the spatial interrogation. The database includes those road accidents that led to physical injuries and loss of human lives between 2007 and 2012 and the spatial analysis was realized using TNTmips 7.3 software facilities. Data aggregation and processing allowed creating the spatial pattern of injury related road accidents through Kernel density estimation at three different levels (national - Romania; county level - Iasi County; local level - Iasi town). Spider graphs were used to create the temporal pattern or road accidents at three levels (daily, weekly and monthly) directly related to their causes. Moreover the spatial and temporal database relates the natural hazards (glazed frost, fog, and blizzard) with the human made ones, giving the opportunity to evaluate the nature of uncertainties in risk

  6. Central nervous system involvement in diffuse large B-cell lymphoma: an analysis of risks and prevention strategies in the post-rituximab era.

    PubMed

    Fletcher, Christopher D; Kahl, Brad S

    2014-10-01

    Central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma (DLBCL) occurs infrequently (approximately 5%), but is almost universally fatal. Controversy exists regarding which factors most reliably identify high risk patients in the post-rituximab era. Clarification is also needed regarding the value of prophylaxis strategies when contemporary rituximab-based chemotherapy regimens (chemoimmunotherapy) are used. A systematic review with focus on the era of chemoimmunotherapy has been performed. Involvement of > 1 extranodal site plus an elevated lactate dehydrogenase level identifies individuals at highest risk (> 20%) for CNS recurrence who merit additional evaluation. Only certain solitary extranodal sites (testis, kidney and breast, but not bones, orbit or epidural space) appear to confer higher risk in patients receiving chemoimmunotherapy. Data from studies employing modern regimens suggest that intrathecal prophylaxis is ineffective even for high risk populations. Systemic prophylaxis (e.g. high dose methotrexate) may be useful, but does not have strong support in the literature. A significant portion of patients with high risk features (˜25%) may already have subclinical CNS disease, which requires alternative detection and treatment strategies. Flow cytometry is a promising approach with increased sensitivity. Widespread use of this approach could redefine what risk and prophylaxis mean. An algorithm for incorporating risk factors, evaluation and treatment is presented.

  7. The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease.

    PubMed Central

    Bürglen, L; Seroz, T; Miniou, P; Lefebvre, S; Burlet, P; Munnich, A; Pequignot, E V; Egly, J M; Melki, J

    1997-01-01

    Mutations of the survival motor neurone gene (SMN) are associated with spinal muscular atrophy (SMA), a frequent lethal autosomal recessive disorder. In spite of this, no phenotype-genotype correlation was observed, since the SMN gene is lacking in the majority of patients affected with either the severe form (type I) or the milder forms (types II and III). Here, we show that the gene encoding p44, a subunit of the basal transcription factor TFIIH, is duplicated in the SMA region and that the p44 gene products (p44t and p44c) differ by three amino acid changes. Gene analysis of a total of 94 unrelated SMA patients revealed that the p44t gene is involved in large-scale deletions associated with Werdnig-Hoffmann disease (type I). The TFIIH polypeptide composition as well as transcription and DNA repair activities are normal in patients lacking the p44t gene on both mutant chromosomes, suggesting that the p44t gene is not critical for the development of SMA. Images Figure 1 Figure 2 PMID:8981949

  8. Detection of an early adult T-cell leukemia-lymphoma clone in lymph nodes with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma involvement.

    PubMed

    Tokunaga, Masahito; Yoshida, Noriaki; Nakano, Nobuaki; Kubota, Ayumu; Takeuchi, Shogo; Takatsuka, Yoshifusa; Seto, Masao; Utsunomiya, Atae

    2016-04-01

    A 58-year-old man was admitted to our hospital with systemic lymphadenopathy and was diagnosed with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALCL) by lymph node biopsy. Although he was a human T-cell leukemia virus type I (HTLV-1) carrier, Southern blot analysis of the lymph node did not show monoclonal integration of HTLV-1 provirus deoxyribonucleic acid (DNA). He achieved complete remission after chemotherapy and subsequently, autologous peripheral blood stem cell transplantation (auto-PBSCT) was performed. Fifteen months after the auto-PBSCT, abnormal lymphocytes in the peripheral blood gradually increased. Southern blot analysis revealed monoclonal integration of HTLV-1 provirus DNA and monoclonal rearrangement of TRB. He was diagnosed with chronic type adult T-cell leukemia-lymphoma (ATL), which immediately progressed to the acute type. He died of tumor progression despite intensive chemotherapy. We analyzed genomic alterations of the ALCL and ATL cells using array comparative genomic hybridization. We found that the genomic alteration pattern differed between the two diseases. T-cell receptor clonality analysis using polymerase chain reaction (PCR) showed that the T-cell clone of the ATL was present in the lymph nodes with ALCL involvement, but not in peripheral blood. This finding suggests that lymph nodes can serve as a niche for ATL development.

  9. An analysis of accident data for franchised public buses in Hong Kong.

    PubMed

    Evans, W A; Courtney, A J

    1985-10-01

    This paper analyses data on accidents involving franchised public buses operating in Hong Kong. The data were obtained from the Royal Hong Kong Police, the Hong Kong Government Transport Department, the two major franchised bus operators and international sources. The analysis includes an international comparison of accidents with emphasis on the situation in Hong Kong compared to urban areas in the United Kingdom. An attempt has been made to identify the characteristics of bus accidents; accident incidence has been related to time of day, day of the week, time of year, weather conditions, driver's age and experience, hours on duty and policy-reported cause. The results indicate that Hong Kong has a high accident rate compared to Japan, the U.K. and the U.S.A., with particularly high pedestrian involvement rates. Bus accidents peak at around 9:00 AM and 4:00 PM but the accident rate is high throughout the day. Monday and Saturday appear to have a higher than average accident rate. The variability of accident rate throughout the year does not seem to be significant and the accident rate does not appear to be influenced by weather conditions. Older, more experienced drivers generally have a safer driving record than their younger, less experienced colleagues. Accident occurrence is related to the time the driver has been on duty. The paper questions the reliability of police-reported accident causation data and suggests improvements in the design of the accident report form and in the training of police investigators. The relevance of the Hong Kong study for accident research in general is also discussed.

  10. An analysis of accident data for franchised public buses in Hong Kong.

    PubMed

    Evans, W A; Courtney, A J

    1985-10-01

    This paper analyses data on accidents involving franchised public buses operating in Hong Kong. The data were obtained from the Royal Hong Kong Police, the Hong Kong Government Transport Department, the two major franchised bus operators and international sources. The analysis includes an international comparison of accidents with emphasis on the situation in Hong Kong compared to urban areas in the United Kingdom. An attempt has been made to identify the characteristics of bus accidents; accident incidence has been related to time of day, day of the week, time of year, weather conditions, driver's age and experience, hours on duty and policy-reported cause. The results indicate that Hong Kong has a high accident rate compared to Japan, the U.K. and the U.S.A., with particularly high pedestrian involvement rates. Bus accidents peak at around 9:00 AM and 4:00 PM but the accident rate is high throughout the day. Monday and Saturday appear to have a higher than average accident rate. The variability of accident rate throughout the year does not seem to be significant and the accident rate does not appear to be influenced by weather conditions. Older, more experienced drivers generally have a safer driving record than their younger, less experienced colleagues. Accident occurrence is related to the time the driver has been on duty. The paper questions the reliability of police-reported accident causation data and suggests improvements in the design of the accident report form and in the training of police investigators. The relevance of the Hong Kong study for accident research in general is also discussed. PMID:4096796

  11. [Analisys of work-related accidents and incidents in an oil refinery in Rio de Janeiro].

    PubMed

    de Souza, Carlos Augusto Vaz; de Freitas, Carlos Machado

    2003-01-01

    Accidents in the chemical industry can have serious consequences for workers, communities, and the environment and are thus highly relevant to public health. This article is the result of an occupational surveillance project involving several public institutions. We analyze 800 work-related accidents that resulted in injuries, environmental damage, or loss of production in 1997 in an oil refinery located in Rio de Janeiro, Brazil. The methodology was based on managerial and organizational approaches to accident investigation, with the European Union reporting system as the reference. The results highlight various limitations in the process of reporting and investigating accidents, as well as a certain hierarchy of accidents, with more attention given to accidents involving loss of production and less to those resulting in injuries, particularly among outsourced workers. PMID:14666211

  12. First Responders and Criticality Accidents

    SciTech Connect

    Valerie L. Putman; Douglas M. Minnema

    2005-11-01

    Nuclear criticality accident descriptions typically include, but do not focus on, information useful to first responders. We studied these accidents, noting characteristics to help (1) first responders prepare for such an event and (2) emergency drill planners develop appropriate simulations for training. We also provide recommendations to help people prepare for such events in the future.

  13. Lockout/tagout accident investigation.

    PubMed

    White, James R

    2014-08-01

    When I was in boot camp, our drill instructor told us that assume makes an ass out of u and me. It was true then, and it is true today. In this instance, assumptions came into play several times, both by the worker and by the companies involved. The good news is that it did not result in a fatality, but that does not relieve the pain and suffering that the employee had to endure. This same type of scenario is likely repeated at many job sites throughout the United States. Multiple contractors, dozens--maybe hundreds--of workers, power system equipment and devices; all of these have to be taken into consideration when performing maintenance activities. It can become a blur. People are people, and people make mistakes. That is why we have OSHA regulations, NFPA 70E, company procedures, policies, etc. Most if not all of us have either been involved in accidents or know people who have been. It's not like it's a secret that people make mistakes, but talk to some and they seem to think only others have that failing. Safety is not about just any one procedure or rule. It's about slowing down, making a plan, and executing that plan. There are plenty of tools available to help us: policies, procedures, codes, standards, federal regulations, and state and local laws. I am not about to say that the worker involved in this incident was not taking safety seriously, but he failed to follow some fundamental safety rules like test-before-touch. If he had taken just that one step, there would be nothing to write about. PMID:25188988

  14. A study of carburetor/induction system icing in general aviation accidents

    NASA Technical Reports Server (NTRS)

    Obermayer, R. W.; Roe, W. T.

    1975-01-01

    An assessment of the frequency and severity of carburetor/induction icing in general-aviation accidents was performed. The available literature and accident data from the National Transportation Safety Board were collected. A computer analysis of the accident data was performed. Between 65 and 90 accidents each year involve carburetor/induction system icing as a probable cause/factor. Under conditions conducive to carburetor/induction icing, between 50 and 70 percent of engine malfunction/failure accidents (exclusive of those due to fuel exhaustion) are due to carburetor/induction system icing. Since the evidence of such icing may not remain long after an accident, it is probable that the frequency of occurrence of such accidents is underestimated; therefore, some extrapolation of the data was conducted. The problem of carburetor/induction system icing is particularly acute for pilots with less than 1000 hours of total flying time. The severity of such accidents is about the same as any accident resulting from a forced landing or precautionary landing. About 144 persons, on the average, are exposed to death and injury each year in accidents involving carburetor/induction icing as a probable cause/factor.

  15. Risk assessment of maintenance operations: the analysis of performing task and accident mechanism.

    PubMed

    Carrillo-Castrillo, Jesús A; Rubio-Romero, Juan Carlos; Guadix, Jose; Onieva, Luis

    2015-01-01

    Maintenance operations cover a great number of occupations. Most small and medium-sized enterprises lack the appropriate information to conduct risk assessments of maintenance operations. The objective of this research is to provide a method based on the concepts of task and accident mechanisms for an initial risk assessment by taking into consideration the prevalence and severity of the maintenance accidents reported. Data were gathered from 11,190 reported accidents in maintenance operations in the manufacturing sector of Andalusia from 2003 to 2012. By using a semi-quantitative methodology, likelihood and severity were evaluated based on the actual distribution of accident mechanisms in each of the tasks. Accident mechanisms and tasks were identified by using those variables included in the European Statistics of Accidents at Work methodology. As main results, the estimated risk of the most frequent accident mechanisms identified for each of the analysed tasks is low and the only accident mechanisms with medium risk are accidents when lifting or pushing with physical stress on the musculoskeletal system in tasks involving carrying, and impacts against objects after slipping or stumbling for tasks involving movements. The prioritisation of public preventive actions for the accident mechanisms with a higher estimated risk is highly recommended.

  16. Hydrogen Peroxide Accidents and Incidents: What We Can Learn From History

    NASA Technical Reports Server (NTRS)

    Greene, Ben; Baker, David L.; Frazier, Wayne

    2005-01-01

    Historical accidents and incidents involving hydrogen peroxide are reviewed and presented. These hydrogen peroxide events are associated with storage, transportation, handling, and disposal and they include exposures, fires, and explosions. Understanding the causes and effects of these accident and incident examples may aid personnel currently working with hydrogen peroxide to mitigate and perhaps avoid similar situations. Lessons learned, best practices, and regulatory compliance information related to the cited accidents and incidents are also discussed.

  17. Transport aircraft accident dynamics

    NASA Technical Reports Server (NTRS)

    Cominsky, A.

    1982-01-01

    A study was carried out of 112 impact survivable jet transport aircraft accidents (world wide) of 27,700 kg (60,000 lb.) aircraft and up extending over the last 20 years. This study centered on the effect of impact and the follow-on events on aircraft structures and was confined to the approach, landing and takeoff segments of the flight. The significant characteristics, frequency of occurrence and the effect on the occupants of the above data base were studied and categorized with a view to establishing typical impact scenarios for use as a basis of verifying the effectiveness of potential safety concepts. Studies were also carried out of related subjects such as: (1) assessment of advanced materials; (2) human tolerance to impact; (3) merit functions for safety concepts; and (4) impact analysis and test methods.

  18. The generation of aerosols by accidents which may occur during plant-scale production of micro-organisms.

    PubMed Central

    Ashcroft, J.; Pomeroy, N. P.

    1983-01-01

    Experiments have been performed to simulate accidents which may occur during large-scale production of micro-organisms. Four types of accident, which were considered to be the most likely to result in the greatest hazard to health, were simulated using a bacterial model. The accidents were all concerned with faults occurring in the operation of the microbial fermenter. Gross contamination of surfaces occurred in all experiments, but only three types of accident produced a measurable aerosol. PMID:6350448

  19. U.S. Civil Rotorcraft Accidents, 1963 through 1997

    NASA Technical Reports Server (NTRS)

    Harris, Franklin D.; Kasper, Eugene F.

    1998-01-01

    The U.S. National Transportation Safety Board (NTSB) has recorded 8,436 rotorcraft accidents during the period mid - 1963 through the end of 1997. Review and analysis of the NTSB summary narrative for each accident has been completed. In addition, FAA (Federal Aviation Administration) counts of the growing registered rotorcraft fleet over this period has obtained. Taken together, a large and informative data base is now available, which indicates that the accident rate (on a per airframe basis) has changed very little since the mid 1970s. The data base, even in the summary form provided by this paper, offers suggestions for safer designs and improved flight operations. For analysis purposes, each accident has been placed in one of 21 top level categories as defined by the NTSB. Analysis of this grouping shows that 70 percent of rotorcraft accidents are associated with four categories. The accident count in these top four categories are: (1) 2,408 Loss of engine power (2) 1,322 In flight collision with object (3) 1,114 Loss of control (4) 1,083 Airframe/component/system failure or malfunction. Single engine rotorcraft dominate these accident statistics because of their sheer numbers over the study period. One-third of the loss of engine power accidents with these aircraft is fuel/air mixture related and fuel exhaustion is a common event. This appears to be the case whether a piston or turbine engine is installed. This paper provides similar study results in the other major mishap categories. It shows that both minor and major design and flight operations changes can -- and should -- be made to reduce rotorcraft accidents in the future. The paper outlines these changes and suggests how they may be made.

  20. Large fractions of CO2-fixing microorganisms in pristine limestone aquifers appear to be involved in the oxidation of reduced sulfur and nitrogen compounds

    USGS Publications Warehouse

    Herrmann, Martina; Rusznyák, Anna; Akob, Denise M.; Schulze, Isabel; Opitz, Sebastian; Totsche, Kai Uwe; Küsel, Kirsten

    2015-01-01

    The traditional view of the dependency of subsurface environments on surface-derived allochthonous carbon inputs is challenged by increasing evidence for the role of lithoautotrophy in aquifer carbon flow. We linked information on autotrophy (Calvin-Benson-Bassham cycle) with that from total microbial community analysis in groundwater at two superimposed—upper and lower—limestone groundwater reservoirs (aquifers). Quantitative PCR revealed that up to 17% of the microbial population had the genetic potential to fix CO2 via the Calvin cycle, with abundances of cbbM and cbbL genes, encoding RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) forms I and II, ranging from 1.14 × 103 to 6 × 106 genes liter−1 over a 2-year period. The structure of the active microbial communities based on 16S rRNA transcripts differed between the two aquifers, with a larger fraction of heterotrophic, facultative anaerobic, soil-related groups in the oxygen-deficient upper aquifer. Most identified CO2-assimilating phylogenetic groups appeared to be involved in the oxidation of sulfur or nitrogen compounds and harbored both RubisCO forms I and II, allowing efficient CO2 fixation in environments with strong oxygen and CO2 fluctuations. The genera Sulfuricellaand Nitrosomonas were represented by read fractions of up to 78 and 33%, respectively, within the cbbM and cbbL transcript pool and accounted for 5.6 and 3.8% of 16S rRNA sequence reads, respectively, in the lower aquifer. Our results indicate that a large fraction of bacteria in pristine limestone aquifers has the genetic potential for autotrophic CO2 fixation, with energy most likely provided by the oxidation of reduced sulfur and nitrogen compounds.

  1. Additional Survival Benefit of Involved-Lesion Radiation Therapy After R-CHOP Chemotherapy in Limited Stage Diffuse Large B-Cell Lymphoma

    SciTech Connect

    Kwon, Jeanny; Kim, Il Han; Kim, Byoung Hyuck; Kim, Tae Min; Heo, Dae Seog

    2015-05-01

    Purpose: The purpose of this study was to evaluate the role of involved-lesion radiation therapy (ILRT) after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy in limited stage diffuse large B-cell lymphoma (DLBCL) by comparing outcomes of R-CHOP therapy alone with R-CHOP followed by ILRT. Methods and Materials: We identified 198 patients treated with R-CHOP (median, 6 cycles) for pathologically confirmed DLBCL of limited stage from July 2004 to December 2012. Clinical characteristics of these patients were 33% with stage I and 66.7% with stage II; 79.8% were in the low or low-intermediate risk group; 13.6% had B symptoms; 29.8% had bulky tumors (≥7 cm); and 75.3% underwent ≥6 cycles of R-CHOP therapy. RT was given to 43 patients (21.7%) using ILRT technique, which included the prechemotherapy tumor volume with a median margin of 2 cm (median RT dose: 36 Gy). Results: After a median follow-up of 40 months, 3-year progression-free survival (PFS) and overall survival (OS) were 85.8% and 88.9%, respectively. Multivariate analysis showed ≥6 cycles of R-CHOP (PFS, P=.004; OS, P=.004) and ILRT (PFS, P=.021; OS, P=.014) were favorable prognosticators of PFS and OS. A bulky tumor (P=.027) and response to R-CHOP (P=.012) were also found to be independent factors of OS. In subgroup analysis, the effect of ILRT was prominent in patients with a bulky tumor (PFS, P=.014; OS, P=.030) or an elevated level of serum lactate dehydrogenase (LDH; PFS, P=.004; OS, P=.012). Conclusions: Our results suggest that ILRT after R-CHOP therapy improves PFS and OS in patients with limited stage DLBCL, especially in those with bulky disease or an elevated serum LDH level.

  2. Large fractions of CO2-fixing microorganisms in pristine limestone aquifers appear to be involved in the oxidation of reduced sulfur and nitrogen compounds.

    PubMed

    Herrmann, Martina; Rusznyák, Anna; Akob, Denise M; Schulze, Isabel; Opitz, Sebastian; Totsche, Kai Uwe; Küsel, Kirsten

    2015-04-01

    The traditional view of the dependency of subsurface environments on surface-derived allochthonous carbon inputs is challenged by increasing evidence for the role of lithoautotrophy in aquifer carbon flow. We linked information on autotrophy (Calvin-Benson-Bassham cycle) with that from total microbial community analysis in groundwater at two superimposed-upper and lower-limestone groundwater reservoirs (aquifers). Quantitative PCR revealed that up to 17% of the microbial population had the genetic potential to fix CO2 via the Calvin cycle, with abundances of cbbM and cbbL genes, encoding RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) forms I and II, ranging from 1.14 × 10(3) to 6 × 10(6) genes liter(-1) over a 2-year period. The structure of the active microbial communities based on 16S rRNA transcripts differed between the two aquifers, with a larger fraction of heterotrophic, facultative anaerobic, soil-related groups in the oxygen-deficient upper aquifer. Most identified CO2-assimilating phylogenetic groups appeared to be involved in the oxidation of sulfur or nitrogen compounds and harbored both RubisCO forms I and II, allowing efficient CO2 fixation in environments with strong oxygen and CO2 fluctuations. The genera Sulfuricella and Nitrosomonas were represented by read fractions of up to 78 and 33%, respectively, within the cbbM and cbbL transcript pool and accounted for 5.6 and 3.8% of 16S rRNA sequence reads, respectively, in the lower aquifer. Our results indicate that a large fraction of bacteria in pristine limestone aquifers has the genetic potential for autotrophic CO2 fixation, with energy most likely provided by the oxidation of reduced sulfur and nitrogen compounds.

  3. High total metabolic tumor volume in PET/CT predicts worse prognosis in diffuse large B cell lymphoma patients with bone marrow involvement in rituximab era.

    PubMed

    Song, Moo-Kon; Yang, Deok-Hwan; Lee, Gyeong-Won; Lim, Sung-Nam; Shin, Seunghyeon; Pak, Kyoung June; Kwon, Seong Young; Shim, Hye Kyung; Choi, Bong-Hoi; Kim, In-Suk; Shin, Dong-Hoon; Kim, Seong-Geun; Oh, So-Yeon

    2016-03-01

    Bone marrow involvement (BMI) in diffuse large B cell lymphoma (DLBCL) was naively regarded as an adverse clinical factor. However, it has been unknown which factor would separate clinical outcomes in DLBCL patients with BMI. Recently, metabolic tumor volume (MTV) on positron emission tomography/computed tomography (PET/CT) was suggested to predict prognosis in several lymphoma types. Therefore, we investigated whether MTV would separate the outcomes in DLBCL patients with BMI. MTV on PET/CT was defined as an initial tumor burden as target lesion ≥ standard uptake value, 2.5 in 107 patients with BMI. Intramedullary (IM) MTV was defined as extent of BMI and total MTV was as whole tumor burden. 260.5 cm(3) and 601.2 cm(3) were ideal cut-off values for dividing high and low MTV status in the IM and total lymphoma lesions in Receiver Operating Curve analysis. High risk NCCN-IPI (p<0.001, p<0.001), bulky disease (p=0.011, p=0.005), concordant subtype (p=0.025, p=0.029), high IM MTV status (p<0.001, p<0.001), high total MTV status (p<0.001, p<0.001), and ≥ 2CAs in BM (p=0.037, p=0.033) were significantly associated with progression-free survival (PFS) and overall survival (OS) than other groups. In multivariate analysis, high risk NCCN-IPI (PFS, p=0.006; OS, p=0.013), concordant subtype (PFS, p=0.005; OS, p=0.007), and high total MTV status (PFS, p<0.001; OS, p<0.001) had independent clinical impacts. MTV had prognostic significances for survivals in DLBCL with BMI. PMID:26851438

  4. An analysis of pilot error-related aircraft accidents

    NASA Technical Reports Server (NTRS)

    Kowalsky, N. B.; Masters, R. L.; Stone, R. B.; Babcock, G. L.; Rypka, E. W.

    1974-01-01

    A multidisciplinary team approach to pilot error-related U.S. air carrier jet aircraft accident investigation records successfully reclaimed hidden human error information not shown in statistical studies. New analytic techniques were developed and applied to the data to discover and identify multiple elements of commonality and shared characteristics within this group of accidents. Three techniques of analysis were used: Critical element analysis, which demonstrated the importance of a subjective qualitative approach to raw accident data and surfaced information heretofore unavailable. Cluster analysis, which was an exploratory research tool that will lead to increased understanding and improved organization of facts, the discovery of new meaning in large data sets, and the generation of explanatory hypotheses. Pattern recognition, by which accidents can be categorized by pattern conformity after critical element identification by cluster analysis.

  5. [Accidents with venomous and poisonous animals in Central Europe].

    PubMed

    Bodio, Mauro; Junghanss, Thomas

    2009-05-01

    Central Europe is largely safe from accidents with venomous and poisonous animals. The regions where European vipers are regularly found are shrinking. Today accidents with jellyfish and stings of venomous fish afflicted during leisure activities at the sea side play the dominant role. Life threatening accidents in Europe are mainly due to exotic snakes held in captivity. A system useful in daily medical practice is explained to classify and stage accidents due to poisonous and venomous animals. The important poisonous and venomous animals of Central Europe and the specific therapeutics, the antivenoms, are covered. The antivenom depot "Antivenin-CH" of the Swiss Toxicology Information Centre in Zurich and the MRITox in Munich with the antivenom registry Munich AntiVenom INdex (MAVIN) are presented.

  6. An Analysis of U.S. Civil Rotorcraft Accidents by Cost and Injury (1990-1996)

    NASA Technical Reports Server (NTRS)

    Iseler, Laura; DeMaio, Joe; Rutkowski, Michael (Technical Monitor)

    2002-01-01

    A study of rotorcraft accidents was conducted to identify safety issues and research areas that might lead to a reduction in rotorcraft accidents and fatalities. The primary source of data was summaries of National Transportation Safety Board (NTSB) accident reports. From 1990 to 1996, the NTSB documented 1396 civil rotorcraft accidents in the United States in which 491 people were killed. The rotorcraft data were compared to airline and general aviation data to determine the relative safety of rotorcraft compared to other segments of the aviation industry. In depth analysis of the rotorcraft data addressed demographics, mission, and operational factors. Rotorcraft were found to have an accident rate about ten times that of commercial airliners and about the same as that of general aviation. The likelihood that an accident would be fatal was about equal for all three classes of operation. The most dramatic division in rotorcraft accidents is between flights flown by private pilots versus professional pilots. Private pilots, flying low cost aircraft in benign environments, have accidents that are due, in large part, to their own errors. Professional pilots, in contrast, are more likely to have accidents that are a result of exacting missions or use of specialized equipment. For both groups judgement error is more likely to lead to a fatal accident than are other types of causes. Several approaches to improving the rotorcraft accident rate are recommended. These mostly address improvement in the training of new pilots and improving the safety awareness of private pilots.

  7. Analysing factors related to slipping, stumbling, and falling accidents at work: Application of data mining methods to Finnish occupational accidents and diseases statistics database.

    PubMed

    Nenonen, Noora

    2013-03-01

    The utilisation of data mining methods has become common in many fields. In occupational accident analysis, however, these methods are still rarely exploited. This study applies methods of data mining (decision tree and association rules) to the Finnish national occupational accidents and diseases statistics database to analyse factors related to slipping, stumbling, and falling (SSF) accidents at work from 2006 to 2007. SSF accidents at work constitute a large proportion (22%) of all accidents at work in Finland. In addition, they are more likely to result in longer periods of incapacity for work than other workplace accidents. The most important factor influencing whether or not an accident at work is related to SSF is the specific physical activity of movement. In addition, the risk of SSF accidents at work seems to depend on the occupation and the age of the worker. The results were in line with previous research. Hence the application of data mining methods was considered successful. The results did not reveal anything unexpected though. Nevertheless, because of the capability to illustrate a large dataset and relationships between variables easily, data mining methods were seen as a useful supplementary method in analysing occupational accident data.

  8. Risk Estimation Methodology for Launch Accidents.

    SciTech Connect

    Clayton, Daniel James; Lipinski, Ronald J.; Bechtel, Ryan D.

    2014-02-01

    As compact and light weight power sources with reliable, long lives, Radioisotope Power Systems (RPSs) have made space missions to explore the solar system possible. Due to the hazardous material that can be released during a launch accident, the potential health risk of an accident must be quantified, so that appropriate launch approval decisions can be made. One part of the risk estimation involves modeling the response of the RPS to potential accident environments. Due to the complexity of modeling the full RPS response deterministically on dynamic variables, the evaluation is performed in a stochastic manner with a Monte Carlo simulation. The potential consequences can be determined by modeling the transport of the hazardous material in the environment and in human biological pathways. The consequence analysis results are summed and weighted by appropriate likelihood values to give a collection of probabilistic results for the estimation of the potential health risk. This information is used to guide RPS designs, spacecraft designs, mission architecture, or launch procedures to potentially reduce the risk, as well as to inform decision makers of the potential health risks resulting from the use of RPSs for space missions.

  9. Psychological Distress and Post-Traumatic Symptoms Following Occupational Accidents

    PubMed Central

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O.; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-01-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers. PMID:25379258

  10. Psychological distress and post-traumatic symptoms following occupational accidents.

    PubMed

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-12-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers.

  11. Psychological distress and post-traumatic symptoms following occupational accidents.

    PubMed

    Ghisi, Marta; Novara, Caterina; Buodo, Giulia; Kimble, Matthew O; Scozzari, Simona; Di Natale, Arianna; Sanavio, Ezio; Palomba, Daniela

    2013-12-01

    Depression and post-traumatic stress disorder frequently occur as a consequence of occupational accidents. To date, research has been primarily focused on high-risk workers, such as police officers or firefighters, and has rarely considered individuals whose occupational environment involves the risk of severe, but not necessarily life-threatening, injury. Therefore, the present study was aimed at assessing the psychological consequences of accidents occurring in several occupational settings (e.g., construction and industry). Thirty-eight victims of occupational accidents (injured workers) and 38 gender-, age-, and years of education-matched workers who never experienced a work accident (control group) were recruited. All participants underwent a semi-structured interview administered by a trained psychologist, and then were requested to fill in the questionnaires. Injured workers reported more severe anxious, post-traumatic and depressive symptoms, and poorer coping skills, as compared to controls. In the injured group low levels of resilience predicted post-traumatic symptomatology, whereas the degree of physical injury and the length of time since the accident did not play a predictive role. The results suggest that occupational accidents may result in a disabling psychopathological condition, and that a brief psychological evaluation should be included in the assessment of seriously injured workers. PMID:25379258

  12. Sleep apnea and occupational accidents: Are oral appliances the solution?

    PubMed Central

    Rabelo Guimarães, Maria De Lourdes; Hermont, Ana Paula

    2014-01-01

    Background: Dental practitioners have a key role in the quality of life and prevention of occupational accidents of workers with Obstructive Sleep Apnea Syndrome (OSAS). Aim: The aim of this study was to review the impact of OSAS, the Continuous Positive Airway Pressure (CPAP) therapy, and the evidence regarding the use of oral appliances (OA) on the health and safety of workers. Materials and Methods: Searches were conducted in MEDLINE (PubMed), Lilacs and Sci ELO. Articles published from January 1980 to June 2014 were included. Results: The research retrieved 2188 articles and 99 met the inclusion criteria. An increase in occupational accidents due to reduced vigilance and attention in snorers and patients with OSAS was observed. Such involvements were related to excessive daytime sleepiness and neurocognitive function impairments. The use of OA are less effective when compared with CPAP, but the results related to excessive sleepiness and cognitive performance showed improvements similar to CPAP. Treatments with OA showed greater patient compliance than the CPAP therapy. Conclusion: OSAS is a prevalent disorder among workers, leads to increased risk of occupational accidents, and has a significant impact on the economy. The CPAP therapy reduces the risk of occupational accidents. The OA can improve the work performance; but there is no scientific evidence associating its use with occupational accidents reduction. Future research should focus on determining the cost-effectiveness of OA as well as its influence and efficacy in preventing occupational accidents. PMID:25568596

  13. ABCG2 is a Direct Transcriptional Target of Hedgehog Signaling and Involved in Stroma-Induced Drug Tolerance in Diffuse Large B-Cell Lymphoma

    PubMed Central

    Singh, Rajesh R; Kunkalla, Kranthi; Qu, Changju; Schlette, Ellen; Neelapu, Sattva S; Samaniego, Felipe; Vega, Francisco

    2011-01-01

    Successful treatment of diffuse large B-cell lymphoma (DLBCL) is frequently hindered by development of resistance to conventional chemotherapy resulting in disease relapse and high mortality. High expression of anti-apoptotic and/or drug transporter proteins induced by oncogenic signaling pathways has been implicated in the development of chemoresistance in cancer. Previously, our studies showed high expression of ATP-binding cassette drug transporter ABCG2 in DLBCL correlated inversely with disease-free and failure-free survival. In this study, we have implicated activated hedgehog (Hh) signaling pathway as a key factor behind high ABCG2 expression in DLBCL through direct upregulation of ABCG2 gene transcription. We have identified a single binding site for GLI transcription factors in the ABCG2 promoter and established its functionality using luciferase reporter, site-directed mutagenesis and chromatin-immunoprecipitation assays. Furthermore, in DLBCL tumor samples, significantly high ABCG2 and GLI1 levels were found in DLBCL tumors with lymph node involvement in comparison to DLBCL tumor cells collected from pleural and/or peritoneal effusions. This suggests a role for the stromal microenvironment in maintaining high levels of ABCG2 and GLI1. Accordingly, in vitro co-culture of DLBCL cells with HS-5 stromal cells increased ABCG2 mRNA and protein levels by paracrine activation of Hh signaling. In addition to ABCG2, co-culture of DLBCL cells with HS-5 cells also resulted in increase expression of the antiapoptotic proteins BCL2, BCL-xL and BCL2A1 and in induced chemotolerance to doxorubicin and methotrexate, drugs routinely used for the treatment of DLBCL. Similarly, activation of Hh signaling in DLBCL cell lines with recombinant Shh N-terminal peptide resulted in increased expression of BCL2 and ABCG2 associated with increased chemotolerance. Finally, functional inhibition of ABCG2 drug efflux activity with fumitremorgin (FTC) or inhibition of Hh signaling with

  14. REAC/TS Radiation Accident Registry: An Overview

    SciTech Connect

    Doran M. Christensen, DO, REAC /TS Associate Director and Staff Physician Becky Murdock, REAC/TS Registry and Health Physics Technician

    2012-12-12

    Over the past four years, REAC/TS has presented a number of case reports from its Radiation Accident Registry. Victims of radiological or nuclear incidents must meet certain dose criteria for an incident to be categorized as an “accident” and be included in the registry. Although the greatest numbers of “accidents” in the United States that have been entered into the registry involve radiation devices, the greater percentage of serious accidents have involved sealed sources of one kind or another. But if one looks at the kinds of accident scenarios that have resulted in extreme consequence, i.e., death, the greater share of deaths has occurred in medical settings.

  15. Blood lead concentration after a shotgun accident.

    PubMed Central

    Gerhardsson, Lars; Dahlin, Lars; Knebel, Richard; Schütz, Andrejs

    2002-01-01

    In an accidental shooting, a man in his late forties was hit in his left shoulder region by about 60 lead pellets from a shotgun. He had injuries to the vessels, the clavicle, muscles, and nerves, with total paralysis of the left arm due to axonal injury. After several surgical revisions and temporary cover with split skin, reconstructive surgery was carried out 54 days after the accident. The brachial plexus was swollen, but the continuity of the nerve trunks was not broken (no neuroma present). We determined the blood lead (BPb) concentration during a follow-up period of 12 months. The BPb concentration increased considerably during the first months. Although 30 lead pellets were removed during the reconstructive surgery, the BPb concentration continued to rise, and reached a peak of 62 microg/dL (3.0 micromol/L) on day 81. Thereafter it started to decline. Twelve months after the accident, BPb had leveled off at about 30 microg/dL. At that time, muscle and sensory functions had partially recovered. The BPb concentration exceeded 30 microg/dL for 9 months, which may have influenced the recovery rate of nerve function. Subjects with a large number of lead pellets or fragments embedded in the body after shooting accidents should be followed for many years by regular determinations of BPb. To obtain a more stable basis for risk assessment, the BPb concentrations should be corrected for variations in the subject's hemoglobin concentration or erythrocyte volume fraction. PMID:11781173

  16. Revised accident source terms for light-water reactors

    SciTech Connect

    Soffer, L.

    1995-02-01

    This paper presents revised accident source terms for light-water reactors incorporating the severe accident research insights gained in this area over the last 15 years. Current LWR reactor accident source terms used for licensing date from 1962 and are contained in Regulatory Guides 1.3 and 1.4. These specify that 100% of the core inventory of noble gases and 25% of the iodine fission products are assumed to be instantaneously available for release from the containment. The chemical form of the iodine fission products is also assumed to be predominantly elemental iodine. These assumptions have strongly affected present nuclear air cleaning requirements by emphasizing rapid actuation of spray systems and filtration systems optimized to retain elemental iodine. A proposed revision of reactor accident source terms and some im implications for nuclear air cleaning requirements was presented at the 22nd DOE/NRC Nuclear Air Cleaning Conference. A draft report was issued by the NRC for comment in July 1992. Extensive comments were received, with the most significant comments involving (a) release fractions for both volatile and non-volatile species in the early in-vessel release phase, (b) gap release fractions of the noble gases, iodine and cesium, and (c) the timing and duration for the release phases. The final source term report is expected to be issued in late 1994. Although the revised source terms are intended primarily for future plants, current nuclear power plants may request use of revised accident source term insights as well in licensing. This paper emphasizes additional information obtained since the 22nd Conference, including studies on fission product removal mechanisms, results obtained from improved severe accident code calculations and resolution of major comments, and their impact upon the revised accident source terms. Revised accident source terms for both BWRS and PWRS are presented.

  17. The contributions of sleep-related risk factors to diurnal car accidents.

    PubMed

    Lucidi, Fabio; Mallia, Luca; Violani, Cristiano; Giustiniani, Gabriele; Persia, Luca

    2013-03-01

    This study was intended to estimate the presence and number of individual sleep-related risk factors in a sample of diurnal car accidents and to analyze the extent to which these risk factors tended to be more represented in diurnal accidents involving only one vehicle, involving young drivers or occurring on non-urban roads. Two hundred fifty-three drivers involved in diurnal accidents were interviewed immediately after the accidents to assess their sleepiness-related personal conditions and the circumstances prior to the accident (i.e., individual sleep-related risk factors), such as poor sleep, changes in habitual sleeping patterns, prolonged wakefulness, self-reported acute sleepiness and daytime sleepiness, night-shift jobs and insomnia. A total of 12.3% of the drivers were classified as having at least one of the seven risk factors assessed in the study, supporting the general notion that drivers' sleepiness conditions are crucial, even in diurnal driving circumstances in which they are less likely to depend on chrono-biological processes. Furthermore, consistent with the guiding hypotheses, specific sleep-related risk factors were more evident in single (vs. multiple) car accidents, among young drivers and in car accidents occurring on non-urban roads. In summary, sleep-related risk factors seemed to have a negative impact on drivers' safety in circumstances of diurnal driving, especially when the accidents involved young individuals and occurred on non-urban roads. PMID:23246705

  18. The contributions of sleep-related risk factors to diurnal car accidents.

    PubMed

    Lucidi, Fabio; Mallia, Luca; Violani, Cristiano; Giustiniani, Gabriele; Persia, Luca

    2013-03-01

    This study was intended to estimate the presence and number of individual sleep-related risk factors in a sample of diurnal car accidents and to analyze the extent to which these risk factors tended to be more represented in diurnal accidents involving only one vehicle, involving young drivers or occurring on non-urban roads. Two hundred fifty-three drivers involved in diurnal accidents were interviewed immediately after the accidents to assess their sleepiness-related personal conditions and the circumstances prior to the accident (i.e., individual sleep-related risk factors), such as poor sleep, changes in habitual sleeping patterns, prolonged wakefulness, self-reported acute sleepiness and daytime sleepiness, night-shift jobs and insomnia. A total of 12.3% of the drivers were classified as having at least one of the seven risk factors assessed in the study, supporting the general notion that drivers' sleepiness conditions are crucial, even in diurnal driving circumstances in which they are less likely to depend on chrono-biological processes. Furthermore, consistent with the guiding hypotheses, specific sleep-related risk factors were more evident in single (vs. multiple) car accidents, among young drivers and in car accidents occurring on non-urban roads. In summary, sleep-related risk factors seemed to have a negative impact on drivers' safety in circumstances of diurnal driving, especially when the accidents involved young individuals and occurred on non-urban roads.

  19. Emergency response to a highway accident in Springfield, Massachusetts, on December 16, 1991

    SciTech Connect

    Not Available

    1992-06-01

    On December 16, 1991, a truck carrying unirradiated (fresh) nuclear fuel was involved in an accident on US Interstate 91, in Springfield, Massachusetts. This report describes the emergency response measures undertaken by local, State, Federal, and private parties. The report also discusses lessons learned'' from the response to the accident and suggests areas where improvements might be made.

  20. Emergency response to a highway accident in Springfield, Massachusetts, on December 16, 1991

    SciTech Connect

    Not Available

    1992-06-01

    On December 16, 1991, a truck carrying unirradiated (fresh) nuclear fuel was involved in an accident on US Interstate 91, in Springfield, Massachusetts. This report describes the emergency response measures undertaken by local, State, Federal, and private parties. The report also discusses ``lessons learned`` from the response to the accident and suggests areas where improvements might be made.

  1. Aircraft accidents : method of analysis

    NASA Technical Reports Server (NTRS)

    1929-01-01

    This report on a method of analysis of aircraft accidents has been prepared by a special committee on the nomenclature, subdivision, and classification of aircraft accidents organized by the National Advisory Committee for Aeronautics in response to a request dated February 18, 1928, from the Air Coordination Committee consisting of the Assistant Secretaries for Aeronautics in the Departments of War, Navy, and Commerce. The work was undertaken in recognition of the difficulty of drawing correct conclusions from efforts to analyze and compare reports of aircraft accidents prepared by different organizations using different classifications and definitions. The air coordination committee's request was made "in order that practices used may henceforth conform to a standard and be universally comparable." the purpose of the special committee therefore was to prepare a basis for the classification and comparison of aircraft accidents, both civil and military. (author)

  2. Spine Immobilizer for Accident Victims

    NASA Technical Reports Server (NTRS)

    Vykukal, H. C.; Lampson, K.

    1983-01-01

    Proposed conformal bladder filled with tiny spheres called "microballoons," enables spine of accident victim to be rapidly immobilized and restrained and permit victim to be safely removed from accident scene in extremely short time after help arrives. Microballoons expand to form rigid mass when pressure within bladder is less than ambient. Bladder strapped to victim is also strapped to rescue chair. Void between bladder and chair is filled with cloth wedges.

  3. Nuclear fuel cycle facility accident analysis handbook

    SciTech Connect

    Ayer, J E; Clark, A T; Loysen, P; Ballinger, M Y; Mishima, J; Owczarski, P C; Gregory, W S; Nichols, B D

    1988-05-01

    The Accident Analysis Handbook (AAH) covers four generic facilities: fuel manufacturing, fuel reprocessing, waste storage/solidification, and spent fuel storage; and six accident types: fire, explosion, tornado, criticality, spill, and equipment failure. These are the accident types considered to make major contributions to the radiological risk from accidents in nuclear fuel cycle facility operations. The AAH will enable the user to calculate source term releases from accident scenarios manually or by computer. A major feature of the AAH is development of accident sample problems to provide input to source term analysis methods and transport computer codes. Sample problems and illustrative examples for different accident types are included in the AAH.

  4. Study of evacuation times based on general accident history

    SciTech Connect

    Mills, G.S.; Neuhauser, K.S.; Smith, J.D.

    1995-12-01

    The RADTRAN 4 computer code, which calculates estimates of accident dose-risk corresponding to specified transportation scenarios, ascribes doses to potentially exposed members of the public. These persons are modeled as not being evacuated from the affected area for 24 hours following a release of radioactive material. Anecdotal evidence has suggested that this value may be unnecessarily conservative; consequently risk estimates are unnecessarily high. An initial survey of recent trucking accidents, reported in newspapers and other periodicals (1988 through 1994), that involved evacuation of the general population in the affected areas was undertaken to establish the actual time required for such evacuations. Accidents involving hazardous materials other than those which are radioactive (e.g., gasoline, insecticides, other chemicals) but also requiring evacuations of nearby residents were included in the survey. However, the resultant set of sufficiently documented trucking incidents yielded rather sparse data [1]. When the probability density distribution of the truck accident data was compared with that resulting from addition of four other (rail and fixed site) incidents, there was no statistically significant difference between them. Therefore, in order to improve the statistical significance of the data set, i.e., maximize the number of pertinent samples, a search for evacuations resulting from all types of accidents was performed. This resulted in many more references; a set of 48 incidents which could be adequately verified was compiled and merged with the original two data sets for a total of 66 evacuation accounts.

  5. Short sleep duration and long spells of driving are associated with the occurrence of Japanese drivers' rear-end collisions and single-car accidents.

    PubMed

    Abe, Takashi; Komada, Yoko; Nishida, Yasushi; Hayashida, Kenichi; Inoue, Yuichi

    2010-06-01

    Sleepiness and fatigue are important risk factors for traffic accidents. However, the relation between the accident type and lack of sleep as well as spells of driving has not been examined sufficiently. This study aimed to clarify that short sleep duration and long spells of driving are more associated with rear-end collisions and single-car accidents as compared with accidents of other types in cases of people who cause accidents. After removing drunken driving as a cause of accidents, 1772 parties involved in accidents were questioned. The quantities of rear-end collisions and single-car accidents were, respectively, 240 and 293. Logistic regression analysis showed that short nocturnal sleep (<6 h) and 10-min increments of spells of driving were significantly associated not only with rear-end collisions but also with single-car accidents as compared with accidents of other types. Furthermore, younger age (accidents as compared with accidents of other types. To prevent such accidents, countermeasures must be considered in light of the characteristics of drivers involved in each type of accident described above.

  6. [Minor and major work accidents in a Puglia business in the food sector: a 10-year study].

    PubMed

    Di Lorenzo, L; Zocchetti, C; Platania, A; De Francesco, G; De Metrio, R; Pirris, A; Gigante, M R

    1998-01-01

    with injuries notified to INAIL ("major" accidents), mostly involved upper limbs; "franchises" were mostly head interested. About 50% of all causes of occupational accidents were mainly associated with unsafe environmental and working situations, whereas the remaining 50% were mainly associated with unsafe behaviour by workers. Heavy smokers showed a higher frequency of "major" accidents. As alcohol consumption rose, she did number of accidents with absence from work. "Minor" accidents, particularly the "medicated" ones, represented the greatest part of occupational injuries. All the considered causes and circumstances contributed to determine the different kinds of accidents. Thereby, it appears necessary for prevention purposes to obtain information about any kind of injury in the different manufacturing sectors. Finally, it seems dutiful to inform workers about the relationships between life habits and occupational accidents. PMID:10217938

  7. [Minor and major work accidents in a Puglia business in the food sector: a 10-year study].

    PubMed

    Di Lorenzo, L; Zocchetti, C; Platania, A; De Francesco, G; De Metrio, R; Pirris, A; Gigante, M R

    1998-01-01

    with injuries notified to INAIL ("major" accidents), mostly involved upper limbs; "franchises" were mostly head interested. About 50% of all causes of occupational accidents were mainly associated with unsafe environmental and working situations, whereas the remaining 50% were mainly associated with unsafe behaviour by workers. Heavy smokers showed a higher frequency of "major" accidents. As alcohol consumption rose, she did number of accidents with absence from work. "Minor" accidents, particularly the "medicated" ones, represented the greatest part of occupational injuries. All the considered causes and circumstances contributed to determine the different kinds of accidents. Thereby, it appears necessary for prevention purposes to obtain information about any kind of injury in the different manufacturing sectors. Finally, it seems dutiful to inform workers about the relationships between life habits and occupational accidents.

  8. [Accidents and their health effects in firemen of rescue and firefighting teams].

    PubMed

    Szubert, Z; Sobala, W

    2000-01-01

    Accidents, traumas and poisoning are the most frequent causes of health impairments among firemen, determined by the nature of their occupation. Their work is directly related with the exposure to various harmful chemical and physical factors, involving at the same time mental stress during rescue and firefighting actions. The aim of the analysis performed was to determine the accident rate, range and causes of accident-related absenteeism among firemen of the rescue and firefighting brigades, as well as to indicate major traumas resulting from accidents at work. The study was carried out in a group of 1503 firemen (7% of the total number of firemen in Poland) employed in the rescue and firefighting brigades, selected at random throughout the country. Workers' personal data, as well as the data on the number of accidents and the number of days of work disability during the years 1994-97 were analysed. Accidents and accident-related absenteeism by age, certified causes and sites (body parts) of traumas were also analysed using the following parameters: the accident rate (the number of accidents per 1000 workers), accident severity rate (the number of work disability days per one accident), and absenteeism rate (the number of accident-related work disability days per 100 employed). In the period under study (1994-97) 352 accidents, involving 301 persons were registered. Thus, the accident rate was 70.3. These accidents were responsible for the period of work disability three times higher (293.5 days/100 workers) than that observed in the male population employed in the national economy, and eight times higher (770.2 days/100 workers) in the 50-59 age group. Dislocations and distortions were the most frequent causes of accident-related absenteeism--48, whereas fractures occupied the second place--25%. Burns were classified among the most severe injuries, resulting in more than 90 days of absenteeism annually, but they made only 7% of absenteeism with frequency rate of

  9. Van Accidents Raise Questions about Teams' Safety on the Road.

    ERIC Educational Resources Information Center

    Willdorf, Nina

    2000-01-01

    Examines factors involved in the greater numbers of traffic accidents as college sports teams travel more frequently and further to compete in intercollegiate events. Suggests that athletes in non-income-generating sports and/or in lower divisions of the National Collegiate Athletic Association are at greater risk because they are more likely to…

  10. 32 CFR 634.29 - Traffic accident investigation reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... resulted in a fatality, personal injury, or estimated damage to Government vehicles or property in excess... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Traffic Supervision § 634.29 Traffic... vehicle involved in an accident, as described in § 634.28, on the installation, must immediately...

  11. [Accidents of fulguration].

    PubMed

    Virenque, C; Laguerre, J

    1976-01-01

    Fulguration, first electric accident in which the man was a victim, is to day better known. A clap of thunder is decomposed in two elements: lightning, and thunder. Lightning is caused by an electrical discharge, either within a cloud, or between two clouds, or, above all, between a cloud and the surface of the ground. Experimental equipments owned by the French Electricity Company and by the Atomic Energy Commission, have allowed to photograph lightnings and to measure certain physical characteristics (Intensity variable between 25 to 100 kA, voltage variable between 20 to 1 000 kV). The frequency of storms was learned: the isokeraunic level, in France, is about 20, meaning that thunder is heard twenty days during one year. Man may be stricken by thunder by direct hit, by sudden bursting, by earth current, or through various conductors. The electric charge which reached him may go to the earth directly by contact with the ground or may dissipate in the air through a bony promontory (elbow). The total number of victims, "wounded" or deceased, is not now known by statistics. Death comes by insulation breakdown of one of several anatomic cephalic formations: skull, meninx, brain. Many various lesions may happen in survivors: loss of consciousness, more or less long, sensorial or motion deficiencies. All these signs are momentary and generally reversible. Besides one may observe much more intense lesions on the skin: burns and, over all, characteristic aborescence (skin effect by high frequency current). The heart is protected, contrarily to what happens with industrial electrocution. The curative treatment is merely symptomatic : reanimation, surgery for burns or associated traumatic lesions. A prevention is researched to help the lonely man, in the country or in the mountains in the houses (lightning conductor, Faraday cage), in vehicles (aircraft, cars, ships). The mysterious and unforseeable character of lightning still stays, leaving a door opened for numerous

  12. [Accidents between motorcycles: analysis of cases that occurred in the state of Paraná between July 2010 and June 2011].

    PubMed

    Golias, Andrey Rogério Campos; Caetano, Rosângela

    2013-05-01

    Statistics for accidents between two motorcycles have been overlooked in the vast number of traffic accidents in Brazil, though they deserve closer analysis. This study sought to conduct an epidemiological analysis into accidents between two motorcycles compared with other accidents based on data in the state of Paraná. Information from the Fire Department site was collected for a period of one year (July 2010 to June 2011), reporting the number and type of accident, day of the week, time, number of victims, gender, age and severity of injuries. Accidents involving two motorcycles represented 3.4% of traffic accidents and 6.2% of accidents involving motorcycles; and the victims of these accidents accounted respectively for 4.4% of victims of traffic accidents and 8.5% victims of motorcycle accidents. Accidents occurring on Saturdays involving males aged between 20 and 29 were more common. Among the ten most populated cities in the state, some revealed high accident rate between two motorcycles, which appears to be related to the total number of motorcycles in the cities concerned. Thus, constant analysis of these indices is essential together with the implementation of measures to ensure safer highway traffic. PMID:23670451

  13. Organizational culture during the accident response process

    SciTech Connect

    Shurberg, D.A.; Haber, S.B. )

    1992-01-01

    A large volume of literature hypothesizes a direct relationship between organizational culture and organizational effectiveness. Culture data have been collected by the authors and others at nuclear power plants (NPPs) and other organizations that demand high reliability. In this paper, the literature and data are used to explore a critical dimension of the accident response process in an NPP: the transition from an anticipatory strategy to an ad hoc strategy. In particular, the effect of organizational culture on the implementation of each of these strategies is examined.

  14. [An investigative report concerning safety and management in the magnetic resonance environment: there are more accidents than expected].

    PubMed

    Doi, Tsukasa; Yamatani, Yuya; Ueyama, Tsuyoshi; Nishiki, Shigeo; Ogura, Akio; Kawamitsu, Hideaki; Tsuchihashi, Toshio; Okuaki, Tomoyuki; Matsuda, Tsuyoshi; Kumashiro, Masayuki

    2011-01-01

    Using a questionnaire, we surveyed 2,500 facilities in Japan to clarify medical accidents concerning the magnetic resonance device and its environment. Data derived from 1,319 valid responses (52.8%), allowed us to analyze the situation of (or the reason for) the occurrence of the accidents and their environmental factors. Five hundred and nine facilities (39% of all facilities) had the experience of magnetically induced displacement of the large ferromagnetic material. Intravenous (I.V.) drip stands were involved the largest number of them: 31% (228 cases). Oxygen bottles had the second largest number of incidents: 20%. There were also many incidents involving various materials brought in by non-medical staff (e.g. stepladder for construction). About 20% of the accidents occurred outside of working hours. Patients in 12% of the facilities (154 facilities) experienced burns. In 39 of the cases, burns were received to the inside of the thighs. In 38 of the cases, patients received burns from an electrical cable touching the skin. There were also frequent incidents of burning regarding the boa. We received reports of burns and pain from the halo vest even though it's required to be worn for MR safety. Regarding incidents of contraindications, 280 patients with pacemakers were brought into the magnetic resonance (MR) inspection room. Twelve percent of the facilities experienced natural quench. Lack of training for the staff who introduce and operate high magnetic field devices are considered involving frequently occurring accidents of attractions and burns at hospitals with over 500 beds caused by carrying in materials.

  15. A survey of accidents occurring during the transport of hazardous substances by road and rail.

    PubMed

    Oggero, A; Darbra, R M; Muñoz, M; Planas, E; Casal, J

    2006-05-20

    A study of 1932 accidents that occurred during the transport of hazardous substances by road and rail from the beginning of the 20th century to July 2004 was carried out. The results obtained show an increase in the frequency of accidents over time. More than half of the accidents happened on roads (63%). The most frequent accidents were releases (78%), followed by fires (28%), explosions (14%) and gas clouds (6%). The various causes of the accidents, the type of substance involved and the consequences for the population (number of people killed, injured or evacuated) were also analysed. Among the diverse measures taken to improve this situation, the training of professional people involved in transportation seems to be of major importance.

  16. EPIDEMIOLOGICAL PROFILE OF SNAKEBITE ACCIDENTS IN A METROPOLITAN AREA OF NORTHEAST BRAZIL

    PubMed Central

    Albuquerque, Polianna L.M.M.; Silva, Geraldo B.; Jacinto, Camilla N.; Lima, Caroline B.; Lima, Juliana B.; Veras, Maria do Socorro B.; Daher, Elizabeth F.

    2013-01-01

    SUMMARY The aim of this study was to describe the epidemiological profile of snakebite accidents reported by the toxicological assistance center in Fortaleza, Ceará, Brazil. Database information on snakebite accidents was analyzed regarding the period from January 2003 to December 2011. A total of 1063 cases were found. The accidents occurred during the rainy months (March, April and May), in urban areas (52.3%), affecting individuals younger than 50 years and predominantly among males (70.7%). The lower limbs were the most frequently affected body area (33.7%). Most accidents involved non-venomous snakes (76.1%). The genus Bothrops was the main one involved in venomous accidents (83%). It is expected that this study can be used as the substrate to improve healthcare surveillance and implementing better measures for the treatment of this population. PMID:24037290

  17. A Kinetics Demonstration Involving a Green-Red-Green Color Change Resulting from a Large-Amplitude pH Oscillation

    ERIC Educational Resources Information Center

    Pfennig, Brian W.; Roberts, Richard T.

    2006-01-01

    An attempt is made to provide chemistry teachers with a chemical demonstration of a clock reaction for the winter holiday season that changes in color from green to red to green again which is used as didactic tool to introduce students to many of the basic principles of kinetics. The reaction involves the oxidation of iodide ion with persulfate…

  18. Faculty Roles, Responsibilities, and Involvement in Campus Safety Initiatives as Perceived by Faculty and Administrators: A Case Study at a Large State University

    ERIC Educational Resources Information Center

    Rollings, Meda Janeen

    2010-01-01

    The study addressed the problem of campus safety and the extent to which faculty and administrators are aware of institutional security policies. Further, the research compared perceptions of administrators and faculty regarding faculty awareness of and involvement in campus safety policy initiatives. The research sought to determine if the…

  19. Consequences of severe nuclear accidents in Europe

    NASA Astrophysics Data System (ADS)

    Seibert, Petra; Arnold, Delia; Mraz, Gabriele; Arnold, Nikolaus; Gufler, Klaus; Kromp-Kolb, Helga; Kromp, Wolfgang; Sutter, Philipp

    2013-04-01

    A first part of the presentation is devoted to the consequences of the severe accident in the 1986 Chernobyl NPP. It lead to a substantial radioactive contaminated of large parts of Europe and thus raised the awareness for off-site nuclear accident consequences. Spatial patterns of the (transient) contamination of the air and (persistent) contamination of the ground were studied by both measurements and model simulations. For a variety of reasons, ground contamination measurements have variability at a range of spatial scales. Results will be reviewed and discussed. Model simulations, including inverse modelling, have shown that the standard source term as defined in the ATMES study (1990) needs to be updated. Sensitive measurements of airborne activities still reveal the presence of low levels of airborne radiocaesium over the northern hemisphere which stems from resuspension. Over time scales of months and years, the distribution of radionuclides in the Earth system is constantly changing, for example relocated within plants, between plants and soil, in the soil, and into water bodies. Motivated by the permanent risk of transboundary impacts from potential major nuclear accidents, the multidisciplinary project flexRISK (see http://flexRISK.boku.ac.at) has been carried out from 2009 to 2012 in Austria to quantify such risks and hazards. An overview of methods and results of flexRISK is given as a second part of the presentation. For each of the 228 NPPs, severe accidents were identified together with relevant inventories, release fractions, and release frequencies. Then, Europe-wide dispersion and dose calculations were performed for 2788 cases, using the Lagrangian particle model FLEXPART. Maps of single-case results as well as various aggregated risk parameters were produced. It was found that substantial consequences (intervention measures) are possible for distances up to 500-1000 km, and occur more frequently for a distance range up to 100-300 km, which is in

  20. Accidents in Malaysian construction industry: statistical data and court cases.

    PubMed

    Chong, Heap Yih; Low, Thuan Siang

    2014-01-01

    Safety and health issues remain critical to the construction industry due to its working environment and the complexity of working practises. This research attempts to adopt 2 research approaches using statistical data and court cases to address and identify the causes and behavior underlying construction safety and health issues in Malaysia. Factual data on the period of 2000-2009 were retrieved to identify the causes and agents that contributed to health issues. Moreover, court cases were tabulated and analyzed to identify legal patterns of parties involved in construction site accidents. Approaches of this research produced consistent results and highlighted a significant reduction in the rate of accidents per construction project in Malaysia.

  1. Analysis and Management of Large-Scale Activities Based on Interface

    NASA Astrophysics Data System (ADS)

    Yang, Shaofan; Ji, Jingwei; Lu, Ligang; Wang, Zhiyi

    Based on the concepts of system safety engineering, life-cycle and interface that comes from American system safety standard MIL-STD-882E, and apply them to the process of risk analysis and management of large-scale activities. Identify the involved personnel, departments, funds and other contents throughout the life cycle of large-scale activities. Recognize and classify the ultimate risk sources of people, objects and environment of large-scale activities from the perspective of interface. Put forward the accident cause analysis model according to the previous large-scale activities' accidents and combine with the analysis of the risk source interface. Analyze the risks of each interface and summary various types of risks the large-scale activities faced. Come up with the risk management consciousness, policies and regulations, risk control and supervision departments improvement ideas.

  2. Identification of severe accident uncertainties

    SciTech Connect

    Rivard, J.B.; Behr, V.L.; Easterling, R.G.; Griesmeyer, J.M.; Haskin, F.E.; Hatch, S.W.; Kolaczkowski, A.M.; Lipinski, R.J.; Sherman, M.P.; Taig, A.R.

    1984-09-01

    Understanding of severe accidents in light-water reactors is currently beset with uncertainty. Because the uncertainties that are present limit the capability to analyze the progression and possible consequences of such accidents, they restrict the technical basis for regulatory actions by the US Nuclear Regulatory Commission (NRC). It is thus necessary to attempt to identify the sources and quantify the influence of these uncertainties. As a part of ongoing NRC severe-accident programs at Sandia National Laboratories, a working group was formed to pool relevant knowledge and experience in assessing the uncertainties attending present (1983) knowledge of severe accidents. This initial report of the Severe Accident Uncertainty Analysis (SAUNA) working group has as its main goal the identification of a consolidated list of uncertainties that affect in-plant processes and systems. Many uncertainties have been identified. A set of key uncertainties summarizes many of the identified uncertainties. Quantification of the influence of these uncertainties, a necessary second step, is not attempted in the present report, although attempts are made qualitatively to demonstrate the relevance of the identified uncertainties.

  3. Accident-precipitating factors for crashes in turbine-powered general aviation aircraft.

    PubMed

    Boyd, Douglas D; Stolzer, Alan

    2016-01-01

    General aviation (14CFR Part 91) accounts for 83% of civil aviation fatalities. While much research has focused on accident causes/pilot demographics in this aviation sector, studies to identify factors leading up to the crash (accident-precipitating factors) are few. Such information could inform on pre-emptive remedial action. With this in mind and considering the paucity of research on turbine-powered aircraft accidents the study objectives were to identify accident-precipitating factors and determine if the accident rate has changed over time for such aircraft operating under 14CFR Part 91. The NTSB Access database was queried for accidents in airplanes (<12,501lb) powered by 1-2 turbine engines and occurring between 1989 and 2013. We developed and utilized an accident-precipitating factor taxonomy. Statistical analyses employed logistic regression, contingency tables and a generalized linear model with Poisson distribution. The "Checklist/Flight Manual Not Followed" was the most frequent accident-precipitating factor category and carried an excess risk (OR 2.34) for an accident with a fatal and/or serious occupant injury. This elevated risk reflected an over-representation of accidents with fatal and/or serious injury outcomes (p<0.001) in the "non-adherence to V Speeds" sub-category. For accidents grouped in the "Inadequate Pre-Flight Planning/Inspection/Procedure" the "inadequate weather planning" sub-category accounted (p=0.036) for the elevated risk (OR 2.22) of an accident involving fatal and/or serious injuries. The "Violation FARs/AIM Deviation" category was also associated with a greater risk for fatal and/or serious injury (OR 2.59) with "Descent below the MDA/failure to execute the missed approach" representing the largest sub-category. Accidents in multi-engine aircraft are more frequent than their single engine counterparts and the decline (50%) in the turbine aircraft accident rate over the study period was likely due, in part, to a 6-fold

  4. Accident-precipitating factors for crashes in turbine-powered general aviation aircraft.

    PubMed

    Boyd, Douglas D; Stolzer, Alan

    2016-01-01

    General aviation (14CFR Part 91) accounts for 83% of civil aviation fatalities. While much research has focused on accident causes/pilot demographics in this aviation sector, studies to identify factors leading up to the crash (accident-precipitating factors) are few. Such information could inform on pre-emptive remedial action. With this in mind and considering the paucity of research on turbine-powered aircraft accidents the study objectives were to identify accident-precipitating factors and determine if the accident rate has changed over time for such aircraft operating under 14CFR Part 91. The NTSB Access database was queried for accidents in airplanes (<12,501lb) powered by 1-2 turbine engines and occurring between 1989 and 2013. We developed and utilized an accident-precipitating factor taxonomy. Statistical analyses employed logistic regression, contingency tables and a generalized linear model with Poisson distribution. The "Checklist/Flight Manual Not Followed" was the most frequent accident-precipitating factor category and carried an excess risk (OR 2.34) for an accident with a fatal and/or serious occupant injury. This elevated risk reflected an over-representation of accidents with fatal and/or serious injury outcomes (p<0.001) in the "non-adherence to V Speeds" sub-category. For accidents grouped in the "Inadequate Pre-Flight Planning/Inspection/Procedure" the "inadequate weather planning" sub-category accounted (p=0.036) for the elevated risk (OR 2.22) of an accident involving fatal and/or serious injuries. The "Violation FARs/AIM Deviation" category was also associated with a greater risk for fatal and/or serious injury (OR 2.59) with "Descent below the MDA/failure to execute the missed approach" representing the largest sub-category. Accidents in multi-engine aircraft are more frequent than their single engine counterparts and the decline (50%) in the turbine aircraft accident rate over the study period was likely due, in part, to a 6-fold

  5. Large national series of patients with Xq28 duplication involving MECP2: Delineation of brain MRI abnormalities in 30 affected patients.

    PubMed

    El Chehadeh, Salima; Faivre, Laurence; Mosca-Boidron, Anne-Laure; Malan, Valérie; Amiel, Jeanne; Nizon, Mathilde; Touraine, Renaud; Prieur, Fabienne; Pasquier, Laurent; Callier, Patrick; Lefebvre, Mathilde; Marle, Nathalie; Dubourg, Christèle; Julia, Sophie; Sarret, Catherine; Francannet, Christine; Laffargue, Fanny; Boespflug-Tanguy, Odile; David, Albert; Isidor, Bertrand; Le Caignec, Cédric; Vigneron, Jacqueline; Leheup, Bruno; Lambert, Laetitia; Philippe, Christophe; Cuisset, Jean-Marie; Andrieux, Joris; Plessis, Ghislaine; Toutain, Annick; Goldenberg, Alice; Cormier-Daire, Valérie; Rio, Marlène; Bonnefont, Jean-Paul; Thevenon, Julien; Echenne, Bernard; Journel, Hubert; Afenjar, Alexandra; Burglen, Lydie; Bienvenu, Thierry; Addor, Marie-Claude; Lebon, Sébastien; Martinet, Danièle; Baumann, Clarisse; Perrin, Laurence; Drunat, Séverine; Jouk, Pierre-Simon; Devillard, Françoise; Coutton, Charles; Lacombe, Didier; Delrue, Marie-Ange; Philip, Nicole; Moncla, Anne; Badens, Catherine; Perreton, Nathalie; Masurel, Alice; Thauvin-Robinet, Christel; Des Portes, Vincent; Guibaud, Laurent

    2016-01-01

    Xq28 duplications encompassing MECP2 have been described in male patients with a severe neurodevelopmental disorder associated with hypotonia and spasticity, severe learning disability, stereotyped movements, and recurrent pulmonary infections. We report on standardized brain magnetic resonance imaging (MRI) data of 30 affected patients carrying an Xq28 duplication involving MECP2 of various sizes (228 kb to 11.7 Mb). The aim of this study was to seek recurrent malformations and attempt to determine whether variations in imaging features could be explained by differences in the size of the duplications. We showed that 93% of patients had brain MRI abnormalities such as corpus callosum abnormalities (n = 20), reduced volume of the white matter (WM) (n = 12), ventricular dilatation (n = 9), abnormal increased hyperintensities on T2-weighted images involving posterior periventricular WM (n = 6), and vermis hypoplasia (n = 5). The occipitofrontal circumference varied considerably between >+2SD in five patients and <-2SD in four patients. Among the nine patients with dilatation of the lateral ventricles, six had a duplication involving L1CAM. The only patient harboring bilateral posterior subependymal nodular heterotopia also carried an FLNA gene duplication. We could not demonstrate a correlation between periventricular WM hyperintensities/delayed myelination and duplication of the IKBKG gene. We thus conclude that patients with an Xq28 duplication involving MECP2 share some similar but non-specific brain abnormalities. These imaging features, therefore, could not constitute a diagnostic clue. The genotype-phenotype correlation failed to demonstrate a relationship between the presence of nodular heterotopia, ventricular dilatation, WM abnormalities, and the presence of FLNA, L1CAM, or IKBKG, respectively, in the duplicated segment.

  6. Large national series of patients with Xq28 duplication involving MECP2: Delineation of brain MRI abnormalities in 30 affected patients.

    PubMed

    El Chehadeh, Salima; Faivre, Laurence; Mosca-Boidron, Anne-Laure; Malan, Valérie; Amiel, Jeanne; Nizon, Mathilde; Touraine, Renaud; Prieur, Fabienne; Pasquier, Laurent; Callier, Patrick; Lefebvre, Mathilde; Marle, Nathalie; Dubourg, Christèle; Julia, Sophie; Sarret, Catherine; Francannet, Christine; Laffargue, Fanny; Boespflug-Tanguy, Odile; David, Albert; Isidor, Bertrand; Le Caignec, Cédric; Vigneron, Jacqueline; Leheup, Bruno; Lambert, Laetitia; Philippe, Christophe; Cuisset, Jean-Marie; Andrieux, Joris; Plessis, Ghislaine; Toutain, Annick; Goldenberg, Alice; Cormier-Daire, Valérie; Rio, Marlène; Bonnefont, Jean-Paul; Thevenon, Julien; Echenne, Bernard; Journel, Hubert; Afenjar, Alexandra; Burglen, Lydie; Bienvenu, Thierry; Addor, Marie-Claude; Lebon, Sébastien; Martinet, Danièle; Baumann, Clarisse; Perrin, Laurence; Drunat, Séverine; Jouk, Pierre-Simon; Devillard, Françoise; Coutton, Charles; Lacombe, Didier; Delrue, Marie-Ange; Philip, Nicole; Moncla, Anne; Badens, Catherine; Perreton, Nathalie; Masurel, Alice; Thauvin-Robinet, Christel; Des Portes, Vincent; Guibaud, Laurent

    2016-01-01

    Xq28 duplications encompassing MECP2 have been described in male patients with a severe neurodevelopmental disorder associated with hypotonia and spasticity, severe learning disability, stereotyped movements, and recurrent pulmonary infections. We report on standardized brain magnetic resonance imaging (MRI) data of 30 affected patients carrying an Xq28 duplication involving MECP2 of various sizes (228 kb to 11.7 Mb). The aim of this study was to seek recurrent malformations and attempt to determine whether variations in imaging features could be explained by differences in the size of the duplications. We showed that 93% of patients had brain MRI abnormalities such as corpus callosum abnormalities (n = 20), reduced volume of the white matter (WM) (n = 12), ventricular dilatation (n = 9), abnormal increased hyperintensities on T2-weighted images involving posterior periventricular WM (n = 6), and vermis hypoplasia (n = 5). The occipitofrontal circumference varied considerably between >+2SD in five patients and <-2SD in four patients. Among the nine patients with dilatation of the lateral ventricles, six had a duplication involving L1CAM. The only patient harboring bilateral posterior subependymal nodular heterotopia also carried an FLNA gene duplication. We could not demonstrate a correlation between periventricular WM hyperintensities/delayed myelination and duplication of the IKBKG gene. We thus conclude that patients with an Xq28 duplication involving MECP2 share some similar but non-specific brain abnormalities. These imaging features, therefore, could not constitute a diagnostic clue. The genotype-phenotype correlation failed to demonstrate a relationship between the presence of nodular heterotopia, ventricular dilatation, WM abnormalities, and the presence of FLNA, L1CAM, or IKBKG, respectively, in the duplicated segment. PMID:26420639

  7. Jerky driving--An indicator of accident proneness?

    PubMed

    Bagdadi, Omar; Várhelyi, András

    2011-07-01

    This study uses continuously logged driving data from 166 private cars to derive the level of jerks caused by the drivers during everyday driving. The number of critical jerks found in the data is analysed and compared with the self-reported accident involvement of the drivers. The results show that the expected number of accidents for a driver increases with the number of critical jerks caused by the driver. Jerk analyses make it possible to identify safety critical driving behaviour or "accident prone" drivers. They also facilitate the development of safety measures such as active safety systems or advanced driver assistance systems, ADAS, which could be adapted for specific groups of drivers or specific risky driving behaviour.

  8. Source term and radiological consequences of the Chernobyl accident

    SciTech Connect

    Mourad, R.; Snell, V.

    1987-01-01

    The objective of this work is to assess the source term and to evaluate the maximum hypothetical individual doses in European countries (including the Soviet Union) from the Chernobyl accident through the analyses of measurements of meteorological data, radiation fields, and airborne and deposited activity in these countries. Applying this information to deduce the source term involves a reversal of the techniques of nuclear accident analysis, which estimate the off-site consequences of postulated accidents. In this study the authors predict the quantities of radionuclides that, if released at Chernobyl and following the calculated trajectories, would explain and unify the observed radiation levels and radionuclide concentrations as measured by European countries and the Soviet Union. The simulation uses the PEAR microcomputer program following the methodology described in Canadian Standards Association standard N288.2. The study was performed before the Soviets published their estimate of the source term and the two results are compared.

  9. School sports accidents: analysis of causes, modes, and frequencies.

    PubMed

    Kelm, J; Ahlhelm, F; Pape, D; Pitsch, W; Engel, C

    2001-01-01

    About 5% of all school children are seriously injured during physical education every year. Because of its influence on children's attitude toward sports and the economic aspects, an evaluation of causes and medical consequences is necessary. In this study, 213 school sports accidents were investigated. Besides diagnosis, the localization of injuries, as well as the duration of the sick leave were documented. Average age of injured students was 13 years. Most of the injured students blamed themselves for the accident. The most common injuries were sprains, contusions, and fractures. Main reasons for the accidents were faults in basic motion training. Playing soccer and basketball were the most frequent reasons for injuries. The upper extremity was more frequently involved than the lower extremity. Sports physicians and teachers should work out a program outlining the individual needs and capabilities of the injured students to reintegrate them into physical education.

  10. Any Questions? An Application of Weick's Model of Organizing to Increase Student Involvement in the Large-Lecture Classroom

    ERIC Educational Resources Information Center

    Ledford, Christy J. W.; Saperstein, Adam K.; Cafferty, Lauren A.; McClintick, Stacey H.; Bernstein, Ethan M.

    2015-01-01

    Microblogs, with their interactive nature, can engage students in community building and sensemaking. Using Weick's model of organizing as a framework, we integrated the use of micromessaging to increase student engagement in the large-lecture classroom. Students asked significantly more questions and asked a greater diversity of questions…

  11. N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit.

    PubMed

    Das, Benu Brata; Sen, Nilkantha; Dasgupta, Somdeb Bose; Ganguly, Agneyo; Majumder, Hemanta K

    2005-04-22

    Leishmania donovani topoisomerase I is an unusual bisubunit enzyme. We have demonstrated earlier that the large and small subunit could be reconstituted in vitro to show topoisomerase I activity. We extend our biochemical study to evaluate the role of the large subunit in topoisomerase activity. The large subunit (LdTOP1L) shows a substantial degree of homology with the core DNA binding domain of the topoisomerase IB family. Two N-terminal truncation constructs, LdTOP1Delta39L (lacking amino acids 1-39) and LdTOP1Delta99L (lacking amino acids 1-99) of the large subunit were generated and mixed with intact small subunit (LdTOP1S). Our observations reveal that residues within amino acids 1-39 of the large subunit have significant roles in modulating topoisomerase I activity (i.e. in vitro DNA relaxation, camptothecin sensitivity, cleavage activity, and DNA binding affinity). Interestingly, the mutant LdTOP1Delta99LS was unable to show topoisomerase I activity. Investigation of the loss of activity indicates that LdTOP1Delta99L was unable to pull down glutathione S-transferase-LdTOP1S in an Ni(2+)-nitrilotriacetic acid co-immobilization experiment. For further analysis, we co-expressed LdTOP1L and LdTOP1S in Escherichia coli BL21(DE3)pLysS cells. The lysate shows topoisomerase I activity. Immunoprecipitation revealed that LdTOP1L could interact with LdTOP1S, indicating the subunit interaction in bacterial cells, whereas immunoprecipitation of bacterial lysate co-expressing LdTOP1Delta99L and LdTOP1S reveals that LdTOP1Delta99L was significantly deficient at interacting with LdTOP1S to reconstitute topoisomerase I activity. This study demonstrates that heterodimerization between the large and small subunits of the bisubunit enzyme appears to be an absolute requirement for topoisomerase activity. The residue within amino acids 1-39 from the N-terminal end of the large subunit regulates DNA topology during relaxation by controlling noncovalent DNA binding or by

  12. Fatigue failure of metal components as a factor in civil aircraft accidents

    NASA Technical Reports Server (NTRS)

    Holshouser, W. L.; Mayner, R. D.

    1972-01-01

    A review of records maintained by the National Transportation Safety Board showed that 16,054 civil aviation accidents occurred in the United States during the 3-year period ending December 31, 1969. Material failure was an important factor in the cause of 942 of these accidents. Fatigue was identified as the mode of the material failures associated with the cause of 155 accidents and in many other accidents the records indicated that fatigue failures might have been involved. There were 27 fatal accidents and 157 fatalities in accidents in which fatigue failures of metal components were definitely identified. Fatigue failures associated with accidents occurred most frequently in landing-gear components, followed in order by powerplant, propeller, and structural components in fixed-wing aircraft and tail-rotor and main-rotor components in rotorcraft. In a study of 230 laboratory reports on failed components associated with the cause of accidents, fatigue was identified as the mode of failure in more than 60 percent of the failed components. The most frequently identified cause of fatigue, as well as most other types of material failures, was improper maintenance (including inadequate inspection). Fabrication defects, design deficiencies, defective material, and abnormal service damage also caused many fatigue failures. Four case histories of major accidents are included in the paper as illustrations of some of the factors invovled in fatigue failures of aircraft components.

  13. Woodworking injuries: a comparative study of work-related and hobby-related accidents.

    PubMed

    Loisel, F; Bonin, S; Jeunet, L; Pauchot, J; Tropet, Y; Obert, L

    2014-10-01

    The primary objective of this study was to describe the injury characteristics and demographics of patients injured during woodworking activities, upon their arrival to the emergency department in a regional of France where this industry is prevalent. The secondary objective was to compare patient and injury characteristics for work-related and hobby-related accidents. A cohort of 87 patients who had suffered a woodworking accident over a two-year period was evaluated; 79 were available for follow-up. The context and circumstances of the accident, nature and location of the injuries and patient demographics were recorded. Hobby-related accidents accounted for two-thirds of the accidents (51/79). Most of the injured workers were either loggers (35%) or carpenters (46%). The hand was injured in 53 cases (67%). Work-related accidents resulted in significantly more serious consequences in terms of hospital stay, work stoppage, resumption of work or retraining than hobby-related accidents. For the workplace accidents, 86% occurred on new machines; more than 25% of the machines involved in accidents at home were over 15 years. Sixty-eight per cent of workers were wearing their safety gear, while only 31% of those injured during recreational woodworking wore the appropriate gear. Several elements of prevention should be improved: information about the need to maintain the equipment, protect the worker with suitable clothing, and learn which maneuvers are considered hazardous. Safety gear should be regularly inspected in the workplace.

  14. Summary of the SRS Severe Accident Analysis Program, 1987--1992

    SciTech Connect

    Long, T.A.; Hyder, M.L.; Britt, T.E.; Allison, D.K.; Chow, S.; Graves, R.D.; DeWald, A.B. Jr.; Monson, P.R. Jr.; Wooten, L.A.

    1992-11-01

    The Severe Accident Analysis Program (SAAP) is a program of experimental and analytical studies aimed at characterizing severe accidents that might occur in the Savannah River Site Production Reactors. The goals of the Severe Accident Analysis Program are: To develop an understanding of severe accidents in SRS reactors that is adequate to support safety documentation for these reactors, including the Safety Analysis Report (SAR), the Probabilistic Risk Assessment (PRA), and other studies evaluating the safety of reactor operation; To provide tools and bases for the evaluation of existing or proposed safety related equipment in the SRS reactors; To provide bases for the development of accident management procedures for the SRS reactors; To develop and maintain on the site a sufficient body of knowledge, including documents, computer codes, and cognizant engineers and scientists, that can be used to authoritatively resolve questions or issues related to reactor accidents. The Severe Accident Analysis Program was instituted in 1987 and has already produced a substantial amount of information, and specialized calculational tools. Products of the Severe Accident Analysis Program (listed in Section 9 of this report) have been used in the development of the Safety Analysis Report (SAR) and the Probabilistic Risk Assessment (PRA), and in the development of technical specifications for the SRS reactors. A staff of about seven people is currently involved directly in the program and in providing input on severe accidents to other SRS activities.

  15. Epidemiology of Accidents in Tile Factories of Mangalore City in Karnataka

    PubMed Central

    Kumar, S Ganesh; Rathnakar, UP; Harsha Kumar, HN

    2010-01-01

    Background: Occupational accidents are a major point of concern in industries. The academic community should take the first step to address the long-neglected concerns of occupational safety. Objective: To assess the prevalence and pattern of occupational accidents. Materials and Methods: A record-based, cross-sectional study was done in three tile factories of Mangalore city, in Karnataka. A total of 416 workers were analyzed for the year 2004, and data regarding age, sex, job duration, type and nature of injury, body parts involved, and time of injury were collected in a prestructured proforma. Statistical Analysis: Proportions, Chi-square test, Univariate and Multivariate analysis. Results: The overall prevalence rate of accidents was found to be 18.5%. It was found that almost around 86% of the accidents had affected the limbs (upper limb 24.7%, lower limb 61%), around half (52%) of the injuries were contributed by superficial injuries, 40% of accidents were due to stepping/striking against objects and while handling. Hand tools and machinery in motion contributed to around 20% of the accidents. Accidents were more common among the younger age group and less-experienced workers. Multiple logistic regression analyses revealed that the age group of 30-39 years had an independent significant association with accidents (OR = 0.21, P = 0.04). Conclusion: Accidents in tile industries are an important occupational health problem in this area of the country. There is a need for proper safety training of the workers. PMID:20606926

  16. Severe accident simulation at Olkiuoto

    SciTech Connect

    Tirkkonen, H.; Saarenpaeae, T.; Cliff Po, L.C.

    1995-09-01

    A personal computer-based simulator was developed for the Olkiluoto nuclear plant in Finland for training in severe accident management. The generic software PCTRAN was expanded to model the plant-specific features of the ABB Atom designed BWR including its containment over-pressure protection and filtered vent systems. Scenarios including core heat-up, hydrogen generation, core melt and vessel penetration were developed in this work. Radiation leakage paths and dose rate distribution are presented graphically for operator use in diagnosis and mitigation of accidents. Operating on an graphically for operator use in diagnosis and mitigation of accidents. Operating on an 486 DX2-66, PCTRAN-TVO achieves a speed about 15 times faster than real-time. A convenient and user-friendly graphic interface allows full interactive control. In this paper a review of the component models and verification runs are presented.

  17. Safety analysis results for cryostat ingress accidents in ITER

    SciTech Connect

    Merrill, B.J.; Cadwallader, L.C.; Petti, D.A.

    1996-12-31

    Accidents involving the ingress of air or water into the cryostat of the International Thermonuclear Experimental Reactor (ITER) tokamak design have been analyzed with a modified version of the MELCOR code for the ITER Non-site Specific Safety Report (NSSR-1). The air ingress accident is the result of a postulated breach of the cryostat boundary into an adjoining room. MELCOR results for this accident demonstrate that the condensed air mass and increased heat loads are not a magnet safety concern, but that the partial vacuum in the adjoining room must be accommodated in the building design. The water ingress accident is the result of a postulated magnet arc that results in melting of a Primary Heat Transport System (PHTS) coolant pipe, discharging PHTS water and PHTS water activated corrosion products and HTO into the cryostat. MELCOR results for this accident demonstrate that the condensed water mass and increased heat loads are not a magnet safety concern, that the cryostat pressure remains below design limits, and that the corrosion product and HTO releases are well within the ITER release limits.

  18. Readmissions due to traffic accidents at a general hospital 1

    PubMed Central

    Paiva, Luciana; Monteiro, Damiana Aparecida Trindade; Pompeo, Daniele Alcalá; Ciol, Márcia Aparecida; Dantas, Rosana Aparecida Spadotti; Rossi, Lídia Aparecida

    2015-01-01

    Abstract Objective: to verify the occurrence and the causes of hospital readmissions within a year after discharge from hospitalizations due to traffic accidents. Methods: victims of multiple traumas due to traffic accidents were included, who were admitted to an Intensive Care Unit. Sociodemographic data, accident circumstances, body regions affected and cause of readmission were collected from the patient histories. Results: among the 109 victims of traffic accidents, the majority were young and adult men. Most hospitalizations due to accidents involved motorcycle drivers (56.9%). The causes of the return to the hospital were: need to continue the surgical treatment (63.2%), surgical site infection (26.3%) and fall related to the physical sequelae of the trauma (10.5%). The rehospitalization rate corresponded to 174/1,000 people/year. Conclusion: the hospital readmission rate in the study population is similar to the rates found in other studies. Victims of severe limb traumas need multiple surgical procedures, lengthier hospitalizations and extended rehabilitation. PMID:26444172

  19. Review of Global Menace of Road Accidents with Special Reference to Malaysia- A Social Perspective

    PubMed Central

    Kareem, Abdul

    2003-01-01

    Road accident is ‘a global tragedy’ with ever-rising trend. The goal of this article includes review of the causes and nature of accidents, statistical data regarding road accidents and the economical impact. 1.17 million deaths occur each year worldwide due to road accidents 70 % of which occur in developing countries. 65% of deaths involve pedestrians, 35 % of which are children. Estimates suggest that 23–34 million people are injured worldwide every year in road crashes - a value almost twice that previously estimated. It is estimated that more than 200 U.S. citizens die each year due to road accidents abroad. Every year in Europe, more than 50,000 peoples are killed in road accidents, and more than 150,000 remain disabled. It is a sad fact that the total number of road accidents in Malaysia exceeded 223,000 in 1999. On the average, 16 persons died from these road accidents, every single day in 1999. Lack of attention, reckless driving, lack of proper protection, speeding, bad personal habits, social and behavioral misconduct and inconsiderate drivers of larger vehicles are some of the problems that cause accidents. In Malaysia, motorcycle fatal accidents (60%) warrant a high degree of concern. Young children and senior citizens are found to be in the vulnerable age group. In Malaysia, in 1999 alone, general insurers paid RM1.67 billion or an average of RM4.6 million a day on motor claims. It is now recognized that road traffic accidents represent a major public health problem, because of the high number of victims involved and because of the seriousness of the consequences for themselves and for their families. PMID:23386795

  20. Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex.

    PubMed Central

    Tan, T H; Wallis, J; Levine, A J

    1986-01-01

    An expression vector utilizing the enhancer and promoter region of the simian virus 40 (SV40) DNA regulating a murine p53 cDNA clone was constructed. The vector produced murine p53 protein in monkey cells identified by five different monoclonal antibodies, three of which were specific for the murine form of p53. The murine p53 produced in monkey cells formed an oligomeric protein complex with the SV40 large tumor antigen. A large number of deletion mutations, in-frame linker insertion mutations, and linker insertion mutations resulting in a frameshift mutation were constructed in the cDNA coding portion of the p53 protein expression vector. The wild-type and mutant p53 cDNA vectors were expressed in monkey cells producing the SV40 large T antigen. The conformation and levels of p53 protein and its ability to form protein complexes with the SV40 T antigen were determined by using five different monoclonal antibodies with quite distinct epitope recognition sites. Insertion mutations between amino acid residues 123 and 215 (of a total of 390 amino acids) eliminated the ability of murine p53 to bind to the SV40 large T antigen. Deletion (at amino acids 11 through 33) and insertion mutations (amino acids 222 through 344) located on either side of this T-antigen-binding protein domain produced a murine p53 protein that bound to the SV40 large T antigen. The same five insertion mutations that failed to bind with the SV40 large T antigen also failed to react with a specific monoclonal antibody, PAb246. In contrast, six additional deletion and insertion mutations that produced p53 protein that did bind with T antigen were each recognized by PAb246. The proposed epitope for PAb246 has been mapped adjacent (amino acids 88 through 109) to the T-antigen-binding domain (amino acids 123 through 215) localized by the mutations mapped in this study. Finally, some insertion mutations that produced a protein that failed to bind to the SV40 T antigen appeared to have an enhanced

  1. Open water scuba diving accidents at Leicester: five years' experience.

    PubMed Central

    Hart, A J; White, S A; Conboy, P J; Bodiwala, G; Quinton, D

    1999-01-01

    OBJECTIVES: The aim of this study was to determine the incidence, type, outcome, and possible risk factors of diving accidents in each year of a five year period presenting from one dive centre to a large teaching hospital accident and emergency (A&E) department. METHODS: All patients included in this study presented to the A&E department at a local teaching hospital in close proximity to the largest inland diving centre in the UK. Our main outcome measures were: presenting symptoms, administration of recompression treatment, mortality, and postmortem examination report where applicable. RESULTS: Overall, 25 patients experienced a serious open water diving accident at the centre between 1992 and 1996 inclusive. The percentage of survivors (n = 18) with symptoms of decompression sickness receiving recompression treatment was 52%. All surviving patients received medical treatment for at least 24 hours before discharge. The median depth of diving accidents was 24 metres (m) (range 7-36 m). During the study period, 1992-96, the number of accidents increased from one to 10 and the incidence of diving accidents increased from four per 100,000 to 15.4 per 100,000. Over the same time period the number of deaths increased threefold. CONCLUSIONS: The aetiology of the increase in the incidence of accidents is multifactorial. Important risk factors were thought to be: rapid ascent (in 48% of patients), cold water, poor visibility, the number of dives per diver, and the experience of the diver. It is concluded that there needs to be an increased awareness of the management of diving injuries in an A&E department in close proximity to an inland diving centre. PMID:10353047

  2. Investigation of the Challenger Accident

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The work of the Presidential Commission on the Space Shuttle Challenger Accident (hereafter referred to as the Rogers Commission) and the work of the National Aeronautics and Space Administration in investigating the causes of the accident were reviewed. In addition to reviewing the five volumes of the Rogers Commission, the entire direct on-line Rogers Commission data base, which included full-text and document retrieval capability was also reviewed. The findings and recommendations contained also include materials submitted for the record, staff investigations, interviews, and trips.

  3. Methods for nuclear air-cleaning-system accident-consequence assessment

    SciTech Connect

    Andrae, R.W.; Bolstad, J.W.; Gregory, W.S.

    1982-01-01

    This paper describes a multilaboratory research program that is directed toward addressing many questions that analysts face when performing air cleaning accident consequence assessments. The program involves developing analytical tools and supportive experimental data that will be useful in making more realistic assessments of accident source terms within and up to the atmospheric boundaries of nuclear fuel cycle facilities. The types of accidents considered in this study includes fires, explosions, spills, tornadoes, criticalities, and equipment failures. The main focus of the program is developing an accident analysis handbook (AAH). We will describe the contents of the AAH, which include descriptions of selected nuclear fuel cycle facilities, process unit operations, source-term development, and accident consequence analyses. Three computer codes designed to predict gas and material propagation through facility air cleaning systems are described. These computer codes address accidents involving fires (FIRAC), explosions (EXPAC), and tornadoes (TORAC). The handbook relies on many illustrative examples to show the analyst how to approach accident consequence assessments. We will use the FIRAC code and a hypothetical fire scenario to illustrate the accident analysis capability.

  4. Atomic-orbital close-coupling calculations for collisions involving fusion relevant highly charged impurity ions using very large basis sets

    SciTech Connect

    Igenbergs, Katharina; Wallerberger, Markus; Schweinzer, Josef; Aumayr, Friedrich

    2012-05-25

    The atomic-orbital close-coupling formalism is a well-known method for the semiclassical treatment of ion-atom collisions. Cross sections for these kinds of collisions are mainly needed in the analysis of certain spectroscopic data from nuclear fusion experiments as well as astrophysical data. We shall outline how the computational implementation can be improved in such a way that collisions involving heavy, highly charged impurity ions, such as Ar{sup 18+} can be treated. Furthermore we show and discuss exemplary results.

  5. [Diving accidents. Emergency treatment of serious diving accidents].

    PubMed

    Schröder, S; Lier, H; Wiese, S

    2004-11-01

    Decompression injuries are potentially life-threatening incidents mainly due to a rapid decline in ambient pressure. Decompression illness (DCI) results from the presence of gas bubbles in the blood and tissue. DCI may be classified as decompression sickness (DCS) generated from the liberation of gas bubbles following an oversaturation of tissues with inert gas and arterial gas embolism (AGE) mainly due to pulmonary barotrauma. People working under hyperbaric pressure, e.g. in a caisson for general construction under water, and scuba divers are exposed to certain risks. Diving accidents can be fatal and are often characterized by organ dysfunction, especially neurological deficits. They have become comparatively rare among professional divers and workers. However, since recreational scuba diving is gaining more and more popularity there is an increasing likelihood of severe diving accidents. Thus, emergency staff working close to areas with a high scuba diving activity, e.g. lakes or rivers, may be called more frequently to a scuba diving accident. The correct and professional emergency treatment on site, especially the immediate and continuous administration of normobaric oxygen, is decisive for the outcome of the accident victim. The definitive treatment includes rapid recompression with hyperbaric oxygen. The value of adjunctive medication, however, remains controversial.

  6. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents.

    PubMed

    Wojcik, A; Gregoire, E; Hayata, I; Roy, L; Sommer, S; Stephan, G; Voisin, P

    2004-01-01

    The analysis of chromosomal aberrations in peripheral blood of radiation accident victims is an established method of biological dosimetry. The dose estimate on the basis of an in vitro calibration curve is straightforward when the radiation exposure is homogeneous and the analysis not delayed. In recent years three radiation accidents occurred, where the irradiation or sampling conditions precluded a simple estimation of the dose. During the Georgian accident soldiers carried in their pockets small sources of 137Cs leading to partial and protracted body exposures. During the Tokai-mura accident, three employees involved in the process of 235U enrichment were exposed to very high doses of gamma rays and neutrons. During the Bialystok accident, five patients with breast cancer undergoing radiotherapy were exposed to a single dose of electrons which reached about 100 Gy. In the present paper the approaches chosen to estimate, by cytogenetic methods, the doses absorbed by the people involved in the accidents are described. PMID:15162038

  7. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents.

    PubMed

    Wojcik, A; Gregoire, E; Hayata, I; Roy, L; Sommer, S; Stephan, G; Voisin, P

    2004-01-01

    The analysis of chromosomal aberrations in peripheral blood of radiation accident victims is an established method of biological dosimetry. The dose estimate on the basis of an in vitro calibration curve is straightforward when the radiation exposure is homogeneous and the analysis not delayed. In recent years three radiation accidents occurred, where the irradiation or sampling conditions precluded a simple estimation of the dose. During the Georgian accident soldiers carried in their pockets small sources of 137Cs leading to partial and protracted body exposures. During the Tokai-mura accident, three employees involved in the process of 235U enrichment were exposed to very high doses of gamma rays and neutrons. During the Bialystok accident, five patients with breast cancer undergoing radiotherapy were exposed to a single dose of electrons which reached about 100 Gy. In the present paper the approaches chosen to estimate, by cytogenetic methods, the doses absorbed by the people involved in the accidents are described.

  8. Fukushima nuclear power plant accident was preventable

    NASA Astrophysics Data System (ADS)

    Kanoglu, Utku; Synolakis, Costas

    2015-04-01

    On 11 March 2011, the fourth largest earthquake in recorded history triggered a large tsunami, which will probably be remembered from the dramatic live pictures in a country, which is possibly the most tsunami-prepared in the world. The earthquake and tsunami caused a major nuclear power plant (NPP) accident at the Fukushima Dai-ichi, owned by Tokyo Electric Power Company (TEPCO). The accident was likely more severe than the 1979 Three Mile Island and less severe than the Chernobyl 1986 accidents. Yet, after the 26 December 2004 Indian Ocean tsunami had hit the Madras Atomic Power Station there had been renewed interest in the resilience of NPPs to tsunamis. The 11 March 2011 tsunami hit the Onagawa, Fukushima Dai-ichi, Fukushima Dai-ni, and Tokai Dai-ni NPPs, all located approximately in a 230km stretch along the east coast of Honshu. The Onagawa NPP was the closest to the source and was hit by an approximately height of 13m tsunami, of the same height as the one that hit the Fukushima Dai-ichi. Even though the Onagawa site also subsided by 1m, the tsunami did not reach to the main critical facilities. As the International Atomic Energy Agency put it, the Onagawa NPP survived the event "remarkably undamaged." At Fukushima Dai-ichi, the three reactors in operation were shut down due to strong ground shaking. The earthquake damaged all offsite electric transmission facilities. Emergency diesel generators (EDGs) provided back up power and started cooling down the reactors. However, the tsunami flooded the facilities damaging 12 of its 13 EDGs and caused a blackout. Among the consequences were hydrogen explosions that released radioactive material in the environment. It is unfortunately clear that TEPCO and Japan's principal regulator Nuclear and Industrial Safety Agency (NISA) had failed in providing a professional hazard analysis for the plant, even though their last assessment had taken place only months before the accident. The main reasons are the following. One

  9. A comparative analysis of accident risks in fossil, hydro, and nuclear energy chains

    SciTech Connect

    Burgherr, P.; Hirschberg, S.

    2008-07-01

    This study presents a comparative assessment of severe accident risks in the energy sector, based on the historical experience of fossil (coal, oil, natural gas, and LPG (Liquefied Petroleum Gas)) and hydro chains contained in the comprehensive Energy-related Severe Accident Database (ENSAD), as well as Probabilistic Safety Assessment (PSA) for the nuclear chain. Full energy chains were considered because accidents can take place at every stage of the chain. Comparative analyses for the years 1969-2000 included a total of 1870 severe ({>=} 5 fatalities) accidents, amounting to 81,258 fatalities. Although 79.1% of all accidents and 88.9% of associated fatalities occurred in less developed, non-OECD countries, industrialized OECD countries dominated insured losses (78.0%), reflecting their substantially higher insurance density and stricter safety regulations. Aggregated indicators and frequency-consequence (F-N) curves showed that energy-related accident risks in non-OECD countries are distinctly higher than in OECD countries. Hydropower in non-OECD countries and upstream stages within fossil energy chains are most accident-prone. Expected fatality rates are lowest for Western hydropower and nuclear power plants; however, the maximum credible consequences can be very large. Total economic damages due to severe accidents are substantial, but small when compared with natural disasters. Similarly, external costs associated with severe accidents are generally much smaller than monetized damages caused by air pollution.

  10. Injuries are not accidents: towards a culture of prevention.

    PubMed

    Bonilla-Escobar, Francisco Javier; Gutiérrez, María Isabel

    2014-01-01

    Injuries are the result of an acute exposure to exhort of energy or a consequence of a deficiency in a vital element that exceeds physiological thresholds resulting threatens life. They are classified as intentional or unintentional. Injuries are considered a global health issue because they cause more than 5 million deaths per year worldwide and they are an important contributor to the burden of disease, especially affecting people of low socioeconomic status in low- and middle-income countries. A common misconception exists where injuries are thought to be the same as accidents; however, accidents are largely used as chance events, without taken in consideration that all these are preventable. This review discusses injuries and accidents in the context of road traffic and emphasizes injuries as preventable events. An understanding of the essence of injuries enables the standardization of terminology in public use and facilitates the development of a culture of prevention among all of us.

  11. Accident rates and types among self-employed private forest owners.

    PubMed

    Lindroos, Ola; Burström, Lage

    2010-11-01

    Half of all Swedish forests are owned by private individuals, and at least 215,000 people work in these privately owned forest holdings. However, only lethal accidents are systematically monitored among self-employed forest workers. Therefore, data from the registries of the Swedish Work Environment Authority, the Labor Insurance Organization and the regional University Hospital in Umeå were gathered to allow us to perform a more in-depth assessment of the rate and types of accidents that occurred among private forest owners. We found large differences between the registries in the type and number of accidents that were reported. We encountered difficulties in defining "self-employed forest worker" and also in determining whether the accidents that did occur happened during work or leisure time. Consequently, the estimates for the accident rate that we obtained varied from 32 to > or = 4300 injured persons per year in Sweden, depending on the registry that was consulted, the definition of the sample population that was used, and the accident severity definition that was employed. Nevertheless, the different registries gave a consistent picture of the types of accidents that occur while individuals are participating in self-employed forestry work. Severe accidents were relatively common, as self-employed forestry work fatalities constituted 7% of the total number of fatalities in the work authority registry. Falling trees were associated with many of these fatal accidents as well as with accidents that resulted in severe non-fatal injuries. Thus, unsafe work methods appeared more related to the occurrence of an accident than the equipment that was being used at the time of the accident (e.g., a chainsaw). Improvement of the workers' skills should therefore be considered to be an important prevention measure that should be undertaken in this field. The challenges in improving the safety in these smallest of companies, which fall somewhere between the purview of

  12. Columbia Accident Investigation Board. Volume One

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Columbia Accident Investigation Board's independent investigation into the February 1, 2003, loss of the Space Shuttle Columbia and its seven-member crew lasted nearly seven months. A staff of more than 120, along with some 400 NASA engineers, supported the Board's 13 members. Investigators examined more than 30,000 documents, conducted more than 200 formal interviews, heard testimony from dozens of expert witnesses, and reviewed more than 3,000 inputs from the general public. In addition, more than 25,000 searchers combed vast stretches of the Western United States to retrieve the spacecraft's debris. In the process, Columbia's tragedy was compounded when two debris searchers with the U.S. Forest Service perished in a helicopter accident. This report concludes with recommendations, some of which are specifically identified and prefaced as 'before return to flight.' These recommendations are largely related to the physical cause of the accident, and include preventing the loss of foam, improved imaging of the Space Shuttle stack from liftoff through separation of the External Tank, and on-orbit inspection and repair of the Thermal Protection System. The remaining recommendations, for the most part, stem from the Board's findings on organizational cause factors. While they are not 'before return to flight' recommendations, they can be viewed as 'continuing to fly' recommendations, as they capture the Board's thinking on what changes are necessary to operate the Shuttle and future spacecraft safely in the mid- to long-term. These recommendations reflect both the Board's strong support for return to flight at the earliest date consistent with the overriding objective of safety, and the Board's conviction that operation of the Space Shuttle, and all human space-flight, is a developmental activity with high inherent risks.

  13. Preliminary dose assessment of the Chernobyl accident

    SciTech Connect

    Hull, A.P.

    1987-01-01

    From the major accident at Unit 4 of the Chernobyl nuclear power station, a plume of airborne radioactive fission products was initially carried northwesterly toward Poland, thence toward Scandinavia and into Central Europe. Reports of the levels of radioactivity in a variety of media and of external radiation levels were collected in the Department of Energy's Emergency Operations Center and compiled into a data bank. Portions of these and other data which were obtained directly from published and official reports were utilized to make a preliminary assessment of the extent and magnitude of the external dose to individuals downwind from Chernobyl. Radioactive /sup 131/I was the predominant fission product. The time of arrival of the plume and the maximum concentrations of /sup 131/I in air, vegetation and milk and the maximum reported depositions and external radiation levels have been tabulated country by country. A large amount of the total activity in the release was apparently carried to a significant elevation. The data suggest that in areas where rainfall occurred, deposition levels were from ten to one-hundred times those observed in nearby ''dry'' locations. Sufficient spectral data were obtained to establish average release fractions and to establish a reference spectra of the other nuclides in the release. Preliminary calculations indicated that the collective dose equivalent to the population in Scandinavia and Central Europe during the first year after the Chernobyl accident would be about 8 x 10/sup 6/ person-rem. From the Soviet report, it appears that a first year population dose of about 2 x 10/sup 7/ person-rem (2 x 10/sup 5/ Sv) will be received by the population who were downwind of Chernobyl within the U.S.S.R. during the accident and its subsequent releases over the following week. 32 refs., 14 figs., 20 tabs.

  14. Radiation damage aspects of the chernobyl accident

    NASA Astrophysics Data System (ADS)

    Parmentier, N.; Nenot, J. C.

    During the night of 25 to 26 April 1986, the most severe nuclear accident occurred at the Chernobyl power station, about 150km north of Kiev, in the Ukraine. It resulted in the irradiation of 237 workers at dose levels justifying medical care. The most severe cases (115) were hospitalized in Moscow, with 20 patients with doses higher than 6 Gy. In most cases, the treatment was classical, based on transfusion of red cells and platelets, and heavy supportive therapy. For 19 patients with severe aplasia, transplantations of bone marrow (13) or foetal liver (6) were decided. Of these patients only one survived, which justifies the statement from U.S.S.R. physicians: after an accident the indications of grafting are limited and its risks may not justify its use. Most of the complications were related to radiation burns which involved 56 victims and resulted in fatal outcomes in at least 19 patients. The population was evacuated from a 30 km zone around the site; based on direct measurements and calculations, the collective dose was evaluated at 1.6 × 10 4 man Sv, with an individual average lower than 250 mSv. The European part of U.S.S.R. with 75 million persons is supposed to have received a collective dose likely to increase the natural mortality by less than 0.1%. The numbers with cancer in the Northern Hemisphere might increase by 0.004% over the next 50 years.

  15. 49 CFR 230.22 - Accident reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirements § 230.22 Accident reports. In the case of an accident due to failure, from any cause, of a steam locomotive boiler or any part or appurtenance thereof, resulting in serious injury or death to one or...

  16. Thyroid consequences of the Chernobyl nuclear accident.

    PubMed

    Pacini, F; Vorontsova, T; Molinaro, E; Shavrova, E; Agate, L; Kuchinskaya, E; Elisei, R; Demidchik, E P; Pinchera, A

    1999-12-01

    It is well recognized that the use of external irradiation of the head and neck to treat patients with various non-thyroid disorders increases their risk of developing papillary thyroid carcinoma years after radiation exposure. An increased risk of thyroid cancer has also been reported in survivors of the atomic bombs in Japan, as well as in Marshall Island residents exposed to radiation during the testing of hydrogen bombs. More recently, exposure to radioactive fallout as a result of the Chernobyl nuclear reactor accident has clearly caused an enormous increase in the incidence of childhood thyroid carcinoma in Belarus, Ukraine, and, to a lesser extent, in the Russian Federation, starting in 1990. When clinical and epidemiological features of thyroid carcinomas diagnosed in Belarus after the Chernobyl accident are compared with those of naturally occurring thyroid carcinomas in patients of the same age group in Italy and France, it becomes apparent that the post-Chernobyl thyroid carcinomas were much less influenced by gender, virtually always papillary (solid and follicular variants), more aggressive at presentation and more frequently associated with thyroid autoimmunity. Gene mutations involving the RET proto-oncogene, and less frequently TRK, have been shown to be causative events specific for papillary cancer. RET activation was found in nearly 70% of the patients who developed papillary thyroid carcinomas following the Chernobyl accident. In addition to thyroid cancer, radiation-induced thyroid diseases include benign thyroid nodules, hypothyroidism and autoimmune thyroiditis, with or without thyroid insufficiency, as observed in populations after environmental exposure to radioisotopes of iodine and in the survivors of atomic bomb explosions. On this basis, the authors evaluated thyroid autoimmune phenomena in normal children exposed to radiation after the Chernobyl accident. The results demonstrated an increased prevalence of circulating thyroid

  17. Thyroid consequences of the Chernobyl nuclear accident.

    PubMed

    Pacini, F; Vorontsova, T; Molinaro, E; Shavrova, E; Agate, L; Kuchinskaya, E; Elisei, R; Demidchik, E P; Pinchera, A

    1999-12-01

    It is well recognized that the use of external irradiation of the head and neck to treat patients with various non-thyroid disorders increases their risk of developing papillary thyroid carcinoma years after radiation exposure. An increased risk of thyroid cancer has also been reported in survivors of the atomic bombs in Japan, as well as in Marshall Island residents exposed to radiation during the testing of hydrogen bombs. More recently, exposure to radioactive fallout as a result of the Chernobyl nuclear reactor accident has clearly caused an enormous increase in the incidence of childhood thyroid carcinoma in Belarus, Ukraine, and, to a lesser extent, in the Russian Federation, starting in 1990. When clinical and epidemiological features of thyroid carcinomas diagnosed in Belarus after the Chernobyl accident are compared with those of naturally occurring thyroid carcinomas in patients of the same age group in Italy and France, it becomes apparent that the post-Chernobyl thyroid carcinomas were much less influenced by gender, virtually always papillary (solid and follicular variants), more aggressive at presentation and more frequently associated with thyroid autoimmunity. Gene mutations involving the RET proto-oncogene, and less frequently TRK, have been shown to be causative events specific for papillary cancer. RET activation was found in nearly 70% of the patients who developed papillary thyroid carcinomas following the Chernobyl accident. In addition to thyroid cancer, radiation-induced thyroid diseases include benign thyroid nodules, hypothyroidism and autoimmune thyroiditis, with or without thyroid insufficiency, as observed in populations after environmental exposure to radioisotopes of iodine and in the survivors of atomic bomb explosions. On this basis, the authors evaluated thyroid autoimmune phenomena in normal children exposed to radiation after the Chernobyl accident. The results demonstrated an increased prevalence of circulating thyroid

  18. Genes involved in nonpermissive temperature-induced cell differentiation in Sertoli TTE3 cells bearing temperature-sensitive simian virus 40 large T-antigen

    SciTech Connect

    Tabuchi, Yoshiaki . E-mail: ytabu@ms.toyama-mpu.ac.jp; Kondo, Takashi; Suzuki, Yoshihisa; Obinata, Masuo

    2005-04-15

    Sertoli TTE3 cells, derived from transgenic mice bearing temperature-sensitive simian virus 40 large T (tsSV40LT)-antigen, proliferated continuously at a permissive temperature (33 deg C) whereas inactivation of the large T-antigen by a nonpermissive temperature (39 deg C) led to differentiation as judged by elevation of transferrin. To clarify the detailed mechanisms of differentiation, we investigated the time course of changes in gene expression using cDNA microarrays. Of the 865 genes analyzed, 14 genes showed increased levels of expression. Real-time quantitative PCR revealed that the mRNA levels of p21{sup waf1}, milk fat globule membrane protein E8, heat-responsive protein 12, and selenoprotein P were markedly elevated. Moreover, the differentiated condition induced by the nonpermissive temperature significantly increased mRNA levels of these four genes in several cell lines from the transgenic mice bearing the oncogene. The present results regarding changes in gene expression will provide a basis for a further understanding of molecular mechanisms of differentiation in both Sertoli cells and cell lines transformed by tsSV40LT-antigen.

  19. A review of accidents, prevention and mitigation options related to hazardous gases

    SciTech Connect

    Fthenakis, V.M.

    1993-05-01

    Statistics on industrial accidents are incomplete due to lack of specific criteria on what constitutes a release or accident. In this country, most major industrial accidents were related to explosions and fires of flammable materials, not to releases of chemicals into the environment. The EPA in a study of 6,928 accidental releases of toxic chemicals revealed that accidents at stationary facilities accounted for 75% of the total number of releases, and transportation accidents for the other 25%. About 7% of all reported accidents (468 cases) resulted in 138 deaths and 4,717 injuries ranging from temporary respiratory problems to critical injuries. In-plant accidents accounted for 65% of the casualties. The most efficient strategy to reduce hazards is to choose technologies which do not require the use of large quantities of hazardous gases. For new technologies this approach can be implemented early in development, before large financial resources and efforts are committed to specific options. Once specific materials and options have been selected, strategies to prevent accident initiating events need to be evaluated and implemented. The next step is to implement safety options which suppress a hazard when an accident initiating event occurs. Releases can be prevented or reduced with fail-safe equipment and valves, adequate warning systems and controls to reduce and interrupt gas leakage. If an accident occurs and safety systems fail to contain a hazardous gas release, then engineering control systems will be relied on to reduce/minimize environmental releases. As a final defensive barrier, the prevention of human exposure is needed if a hazardous gas is released, in spite of previous strategies. Prevention of consequences forms the final defensive barrier. Medical facilities close by that can accommodate victims of the worst accident can reduce the consequences of personnel exposure to hazardous gases.

  20. Delta launch vehicle accident investigation

    NASA Astrophysics Data System (ADS)

    1986-03-01

    The text of the testimony given by several witnesses during the House hearings on the Delta launch vehicle accident of May 3, 1986 is given. Pre-launch procedures, failure analysis, the possibility of sabotage, and design and testing are among the topics discussed.

  1. Determinants of injuries in passenger vessel accidents.

    PubMed

    Yip, Tsz Leung; Jin, Di; Talley, Wayne K

    2015-09-01

    This paper investigates determinants of crew and passenger injuries in passenger vessel accidents. Crew and passenger injury equations are estimated for ferry, ocean cruise, and river cruise vessel accidents, utilizing detailed data of individual vessel accidents that were investigated by the U.S. Coast Guard during the time period 2001-2008. The estimation results provide empirical evidence (for the first time in the literature) that crew injuries are determinants of passenger injuries in passenger vessel accidents.

  2. Determinants of injuries in passenger vessel accidents.

    PubMed

    Yip, Tsz Leung; Jin, Di; Talley, Wayne K

    2015-09-01

    This paper investigates determinants of crew and passenger injuries in passenger vessel accidents. Crew and passenger injury equations are estimated for ferry, ocean cruise, and river cruise vessel accidents, utilizing detailed data of individual vessel accidents that were investigated by the U.S. Coast Guard during the time period 2001-2008. The estimation results provide empirical evidence (for the first time in the literature) that crew injuries are determinants of passenger injuries in passenger vessel accidents. PMID:26070017

  3. Analysis of Surface Water Pollution Accidents in China: Characteristics and Lessons for Risk Management

    NASA Astrophysics Data System (ADS)

    Yao, Hong; Zhang, Tongzhu; Liu, Bo; Lu, Feng; Fang, Shurong; You, Zhen

    2016-04-01

    Understanding historical accidents is important for accident prevention and risk mitigation; however, there are no public databases of pollution accidents in China, and no detailed information regarding such incidents is readily available. Thus, 653 representative cases of surface water pollution accidents in China were identified and described as a function of time, location, materials involved, origin, and causes. The severity and other features of the accidents, frequency and quantities of chemicals involved, frequency and number of people poisoned, frequency and number of people affected, frequency and time for which pollution lasted, and frequency and length of pollution zone were effectively used to value and estimate the accumulated probabilities. The probabilities of occurrences of various types based on origin and causes were also summarized based on these observations. The following conclusions can be drawn from these analyses: (1) There was a high proportion of accidents involving multi-district boundary regions and drinking water crises, indicating that more attention should be paid to environmental risk prevention and the mitigation of such incidents. (2) A high proportion of accidents originated from small-sized chemical plants, indicating that these types of enterprises should be considered during policy making. (3) The most common cause (49.8 % of the total) was intentional acts (illegal discharge); accordingly, efforts to increase environmental consciousness in China should be enhanced.

  4. Analysis of Surface Water Pollution Accidents in China: Characteristics and Lessons for Risk Management.

    PubMed

    Yao, Hong; Zhang, Tongzhu; Liu, Bo; Lu, Feng; Fang, Shurong; You, Zhen

    2016-04-01

    Understanding historical accidents is important for accident prevention and risk mitigation; however, there are no public databases of pollution accidents in China, and no detailed information regarding such incidents is readily available. Thus, 653 representative cases of surface water pollution accidents in China were identified and described as a function of time, location, materials involved, origin, and causes. The severity and other features of the accidents, frequency and quantities of chemicals involved, frequency and number of people poisoned, frequency and number of people affected, frequency and time for which pollution lasted, and frequency and length of pollution zone were effectively used to value and estimate the accumulated probabilities. The probabilities of occurrences of various types based on origin and causes were also summarized based on these observations. The following conclusions can be drawn from these analyses: (1) There was a high proportion of accidents involving multi-district boundary regions and drinking water crises, indicating that more attention should be paid to environmental risk prevention and the mitigation of such incidents. (2) A high proportion of accidents originated from small-sized chemical plants, indicating that these types of enterprises should be considered during policy making. (3) The most common cause (49.8% of the total) was intentional acts (illegal discharge); accordingly, efforts to increase environmental consciousness in China should be enhanced.

  5. An Efficient Large-Scale Retroviral Transduction Method Involving Preloading the Vector into a RetroNectin-Coated Bag with Low-Temperature Shaking

    PubMed Central

    Dodo, Katsuyuki; Chono, Hideto; Saito, Naoki; Tanaka, Yoshinori; Tahara, Kenichi; Nukaya, Ikuei; Mineno, Junichi

    2014-01-01

    In retroviral vector-mediated gene transfer, transduction efficiency can be hampered by inhibitory molecules derived from the culture fluid of virus producer cell lines. To remove these inhibitory molecules to enable better gene transduction, we had previously developed a transduction method using a fibronectin fragment-coated vessel (i.e., the RetroNectin-bound virus transduction method). In the present study, we developed a method that combined RetroNectin-bound virus transduction with low-temperature shaking and applied this method in manufacturing autologous retroviral-engineered T cells for adoptive transfer gene therapy in a large-scale closed system. Retroviral vector was preloaded into a RetroNectin-coated bag and incubated at 4°C for 16 h on a reciprocating shaker at 50 rounds per minute. After the supernatant was removed, activated T cells were added to the bag. The bag transduction method has the advantage of increasing transduction efficiency, as simply flipping over the bag during gene transduction facilitates more efficient utilization of the retroviral vector adsorbed on the top and bottom surfaces of the bag. Finally, we performed validation runs of endoribonuclease MazF-modified CD4+ T cell manufacturing for HIV-1 gene therapy and T cell receptor-modified T cell manufacturing for MAGE-A4 antigen-expressing cancer gene therapy and achieved over 200-fold (≥1010) and 100-fold (≥5×109) expansion, respectively. In conclusion, we demonstrated that the large-scale closed transduction system is highly efficient for retroviral vector-based T cell manufacturing for adoptive transfer gene therapy, and this technology is expected to be amenable to automation and improve current clinical gene therapy protocols. PMID:24454964

  6. An efficient large-scale retroviral transduction method involving preloading the vector into a RetroNectin-coated bag with low-temperature shaking.

    PubMed

    Dodo, Katsuyuki; Chono, Hideto; Saito, Naoki; Tanaka, Yoshinori; Tahara, Kenichi; Nukaya, Ikuei; Mineno, Junichi

    2014-01-01

    In retroviral vector-mediated gene transfer, transduction efficiency can be hampered by inhibitory molecules derived from the culture fluid of virus producer cell lines. To remove these inhibitory molecules to enable better gene transduction, we had previously developed a transduction method using a fibronectin fragment-coated vessel (i.e., the RetroNectin-bound virus transduction method). In the present study, we developed a method that combined RetroNectin-bound virus transduction with low-temperature shaking and applied this method in manufacturing autologous retroviral-engineered T cells for adoptive transfer gene therapy in a large-scale closed system. Retroviral vector was preloaded into a RetroNectin-coated bag and incubated at 4°C for 16 h on a reciprocating shaker at 50 rounds per minute. After the supernatant was removed, activated T cells were added to the bag. The bag transduction method has the advantage of increasing transduction efficiency, as simply flipping over the bag during gene transduction facilitates more efficient utilization of the retroviral vector adsorbed on the top and bottom surfaces of the bag. Finally, we performed validation runs of endoribonuclease MazF-modified CD4(+) T cell manufacturing for HIV-1 gene therapy and T cell receptor-modified T cell manufacturing for MAGE-A4 antigen-expressing cancer gene therapy and achieved over 200-fold (≥ 10(10)) and 100-fold (≥ 5 × 10(9)) expansion, respectively. In conclusion, we demonstrated that the large-scale closed transduction system is highly efficient for retroviral vector-based T cell manufacturing for adoptive transfer gene therapy, and this technology is expected to be amenable to automation and improve current clinical gene therapy protocols.

  7. NASA Medical Response to Human Spacecraft Accidents

    NASA Technical Reports Server (NTRS)

    Patlach, Robert

    2010-01-01

    Manned space flight is risky business. Accidents have occurred and may occur in the future. NASA's manned space flight programs, with all their successes, have had three fatal accidents, one at the launch pad and two in flight. The Apollo fire and the Challenger and Columbia accidents resulted in a loss of seventeen crewmembers. Russia's manned space flight programs have had three fatal accidents, one ground-based and two in flight. These accidents resulted in the loss of five crewmembers. Additionally, manned spacecraft have encountered numerous close calls with potential for disaster. The NASA Johnson Space Center Flight Safety Office has documented more than 70 spacecraft incidents, many of which could have become serious accidents. At the Johnson Space Center (JSC), medical contingency personnel are assigned to a Mishap Investigation Team. The team deploys to the accident site to gather and preserve evidence for the Accident Investigation Board. The JSC Medical Operations Branch has developed a flight surgeon accident response training class to capture the lessons learned from the Columbia accident. This presentation will address the NASA Mishap Investigation Team's medical objectives, planned response, and potential issues that could arise subsequent to a manned spacecraft accident. Educational Objectives are to understand the medical objectives and issues confronting the Mishap Investigation Team medical personnel subsequent to a human space flight accident.

  8. 48 CFR 836.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Accident prevention. 836... prevention. The contracting officer must insert the clause at 852.236-87, Accident Prevention, in solicitations and contracts for construction that contain the clause at FAR 52.236-13, Accident Prevention....

  9. 48 CFR 636.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Accident prevention. 636... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 636.513 Accident prevention. (a) In... contracting activities shall insert DOSAR 652.236-70, Accident Prevention, in lieu of FAR clause...

  10. 48 CFR 1836.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accident prevention. 1836... 1836.513 Accident prevention. The contracting officer must insert the clause at 1852.223-70, Safety and Health, in lieu of FAR clause 52.236-13, Accident Prevention, and its Alternate I....

  11. Legal considerations on the liability of damage compensation in medical accidents in China.

    PubMed

    Shen, Xiuqin; Chen, Xiaoyang

    2008-12-01

    In the past years, there has been an increasing number of medical accidents in various places around the country. Some of them often led to medical litigations. The responsibility of medical accident compensation is the key factor, which involves either the harmony between physician-patient relationship, or the realization of patients' rights. Though relevant legal provisions on the responsibility of medical accidents have been made in national law, regulation and some judicial interpretation, there exist so many problems in reality, such as the uniformity of law application, compensational rate and the deficiency of compensational scope and method. Therefore, in this article, the author tries to analysis the attribute of medical accident compensation, relevant laws and regulations and the problems in practical life, and to put forward advice on how to perfect medical accident legislation.

  12. Tire blow-outs and motorway accidents.

    PubMed

    Martin, Jean-Louis; Laumon, Bernard

    2005-03-01

    During the period from 1996 to 2002, 60,397 vehicles were involved in crashes with property damage and/or injury on a French motorway network of 2000 km. It was observed that 6.7% of these accidents involved tire blow-outs. In 87% of cases, only one vehicle was involved in the accident. Tire blow-outs occurred in 6.5% of cars that represented more than 80% of the vehicles involved in crashes. The occurrence of this phenomenon is very high for vans (22%), though it concerns trucks less (2.5%). The proportion of tire blow-outs decreased from 1997, when it was 8.0%, to 5.9% in 2002. However, two main facts require examination: (1) On inter-urban motorways, crashes involving blow-outs of rear tires occur four times more frequently than for blow-outs of front tires. (2) The frequency of tire blow-outs is especially high for vans, and almost always involves rear tires. This higher frequency for rear tires is the result of two phenomena, which are indistinguishable given the data available: firstly, a four-wheel vehicle is more difficult to control if a blow-out occurs on a rear tire (confirmed experimentally); secondly, rear tires may be in poor condition more often than front tires, and so more prone to blow-outs. Consequently, users are strongly recommended to install the best tires on rear wheels. In practice, if only the front tires are replaced, which often occurs because they tend to be worn out more quickly than the rear ones (especially for front wheel drive vehicles), it is necessary to move the rear tires to the front and fit the new ones on the rear wheels. Very interesting technological developments are in progress that should reduce the number of tire blow-outs. However, considering the time necessary to renew the number of cars on the roads, this very simple and inexpensive recommendation should apply to all cars and especially to vans. PMID:15823875

  13. Industrial Accidents Triggered by Natural Hazards: an Emerging Risk Issue

    NASA Astrophysics Data System (ADS)

    Renni, Elisabetta; Krausmann, Elisabeth; Basco, Anna; Salzano, Ernesto; Cozzani, Valerio

    2010-05-01

    Natural disasters such as earthquakes, tsunamis, flooding or hurricanes have recently and dramatically hit several countries worldwide. Both direct and indirect consequences involved the population, causing on the one hand a high number of fatalities and on the other hand so relevant economical losses that the national gross product may be affected for many years. Loss of critical industrial infrastructures (electricity generation and distribution, gas pipelines, oil refineries, etc.) also occurred, causing further indirect damage to the population. In several cases, accident scenarios with large releases of hazardous materials were triggered by these natural events, causing so-called "Natech events", in which the overall damage resulted from the simultaneous consequences of the natural event and of the release of hazardous substances. Toxic releases, large fires and explosions, as well as possible long-term environmental pollution, economical losses, and overloading of emergency systems were recognised by post-event studies as the main issues of these Natech scenarios. In recent years the increasing frequency and severity of some natural hazards due to climate change has slowly increased the awareness of Natech risk as an emerging risk among the stakeholders. Indeed, the iNTeg-Risk project, co-funded by the European Commission within the 7th Framework Program specifically addresses these scenarios among new technological issues on public safety. The present study, in part carried out within the iNTeg-Risk project, was aimed at the analysis and further development of methods and tools for the assessment and mitigation of Natech accidents. Available tools and knowledge gaps in the assessment of Natech scenarios were highlighted. The analysis mainly addressed the potential impact of flood, lightning and earthquake events on industrial installations where hazardous substances are present. Preliminary screening methodologies and more detailed methods based on

  14. Accident management information needs

    SciTech Connect

    Hanson, D.J.; Ward, L.W.; Nelson, W.R.; Meyer, O.R. )

    1990-04-01

    The tables contained in this Appendix A describe the information needs for a pressurized water reactor (PWR) with a large, dry containment. To identify these information needs, the branch points in the safety objective trees were examined to decide what information is necessary to (a) determine the status of the safety functions in the plant, i.e., whether the safety functions are being adequately maintained within predetermined limits, (b) identify plant behavior (mechanisms) or precursors to this behavior which indicate that a challenge to plant safety is occurring or is imminent, and (c) select strategies that will prevent or mitigate this plant behavior and monitor the implementation and effectiveness of these strategies. The information needs for the challenges to the safety functions are not examined since the summation of the information needs for all mechanisms associated with a challenge comprise the information needs for the challenge itself.

  15. Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth.

    PubMed

    Riera, Ludovica; Lasorsa, Elena; Ambrogio, Chiara; Surrenti, Nadia; Voena, Claudia; Chiarle, Roberto

    2010-08-20

    Most anaplastic large cell lymphomas (ALCL) express oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. Frequently ALCL carry the t(2;5) translocation, which fuses the ALK gene to the nucleophosmin (NPM1) gene. The transforming activity mediated by NPM-ALK fusion induces different pathways that control proliferation and survival of lymphoma cells. Grb2 is an adaptor protein thought to play an important role in ALK-mediated transformation, but its interaction with NPM-ALK, as well as its function in regulating ALCL signaling pathways and cell growth, has never been elucidated. Here we show that active NPM-ALK, but not a kinase-dead mutant, bound and induced Grb2 phosphorylation in tyrosine 160. An intact SH3 domain at the C terminus of Grb2 was required for Tyr(160) phosphorylation. Furthermore, Grb2 did not bind to a single region but rather to different regions of NPM-ALK, mainly Tyr(152-156), Tyr(567), and a proline-rich region, Pro(415-417). Finally, shRNA knockdown experiments showed that Grb2 regulates primarily the NPM-ALK-mediated phosphorylation of SHP2 and plays a key role in ALCL cell growth.

  16. Gypsum amendment to rice paddy soil stimulated bacteria involved in sulfur cycling but largely preserved the phylogenetic composition of the total bacterial community.

    PubMed

    Wörner, Susanne; Zecchin, Sarah; Dan, Jianguo; Todorova, Nadezhda Hristova; Loy, Alexander; Conrad, Ralf; Pester, Michael

    2016-06-01

    Rice paddies are indispensable for human food supply but emit large amounts of the greenhouse gas methane. Sulfur cycling occurs at high rates in these water-submerged soils and controls methane production, an effect that is increased by sulfate-containing fertilizers or soil amendments. We grew rice plants until their late vegetative phase with and without gypsum (CaSO4 ·2H2 O) amendment and identified responsive bacteria by 16S rRNA gene amplicon sequencing. Gypsum amendment decreased methane emissions by up to 99% but had no major impact on the general phylogenetic composition of the bacterial community. It rather selectively stimulated or repressed a small number of 129 and 27 species-level operational taxonomic units (OTUs) (out of 1883-2287 observed) in the rhizosphere and bulk soil, respectively. Gypsum-stimulated OTUs were affiliated with several potential sulfate-reducing (Syntrophobacter, Desulfovibrio, unclassified Desulfobulbaceae, unclassified Desulfobacteraceae) and sulfur-oxidizing taxa (Thiobacillus, unclassified Rhodocyclaceae), while gypsum-repressed OTUs were dominated by aerobic methanotrophs (Methylococcaceae). Abundance correlation networks suggested that two abundant (>1%) OTUs (Desulfobulbaceae, Rhodocyclaceae) were central to the reductive and oxidative parts of the sulfur cycle. PMID:27085098

  17. Analysis of Crew Fatigue in AIA Guantanamo Bay Aviation Accident

    NASA Technical Reports Server (NTRS)

    Rosekind, Mark R.; Gregory, Kevin B.; Miller, Donna L.; Co, Elizabeth L.; Lebacqz, J. Victor; Statler, Irving C. (Technical Monitor)

    1994-01-01

    Flight operations can engender fatigue, which can affect flight crew performance, vigilance, and mood. The National Transportation Safety Board (NTSB) requested the NASA Fatigue Countermeasures Program to analyze crew fatigue factors in an aviation accident that occurred at Guantanamo Bay, Cuba. There are specific fatigue factors that can be considered in such investigations: cumulative sleep loss, continuous hours of wakefulness prior to the incident or accident, and the time of day at which the accident occurred. Data from the NTSB Human Performance Investigator's Factual Report, the Operations Group Chairman's Factual Report, and the Flight 808 Crew Statements were analyzed, using conservative estimates and averages to reconcile discrepancies among the sources. Analysis of these data determined the following: the entire crew displayed cumulative sleep loss, operated during an extended period of continuous wakefulness, and obtained sleep at times in opposition to the circadian disposition for sleep, and that the accident occurred in the afternoon window of physiological sleepiness. In addition to these findings, evidence that fatigue affected performance was suggested by the cockpit voice recorder (CVR) transcript as well as in the captain's testimony. Examples from the CVR showed degraded decision-making skills, fixation, and slowed responses, all of which can be affected by fatigue; also, the captain testified to feeling "lethargic and indifferent" just prior to the accident. Therefore, the sleep/wake history data supports the hypothesis that fatigue was a factor that affected crewmembers' performance. Furthermore, the examples from the CVR and the captain's testimony support the hypothesis that the fatigue had an impact on specific actions involved in the occurrence of the accident.

  18. Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3

    PubMed Central

    1987-01-01

    Continuous cell lines could be reproducibly established by culturing spleen cells from adult mice injected with MLV-producer cells or directly infected with Mo-MLV with rIL-2, whereas the culture of normal splenic cells with rIL-2 induced only transient and limited proliferation resulting in no such lines. All of the lines showed morphological characteristics as LGL with Thy-1+,Lyt-1-,L3T4-,Lyt-2- ,AsGM1+,FcR gamma+ phenotype without exception, and most of them exhibited typical NK-patterned cytotoxicity. Analysis of reverse transcriptase activity of the culture supernatants as well as Southern hybridization of the DNA from the lines using an Mo-MLV-specific cDNA probe indicated no evidence of retroviral replication or proviral integration, suggesting that the generation of cell lines reflected a reactive process and viral infection was not directly responsible. It was subsequently revealed that Thy-1+,Lyt-1+,Lyt-2- spleen cells from mice infected with Mo-MLV in vivo spontaneously produced surprising amounts of IL-3 in vitro, leading to the possibility that IL-3 was responsible for the generation of lines. The possibility was directly supported by the observation that continuous lines with identical characteristics could be generated completely in vitro by sequential stimulation with rIL-3 and rIL-2 from normal spleen cells without any involvement of Mo-MLV. The C beta gene of TCR was shown to be rearranged in all the lines examined, indicating the LGL lines were all genetically committed to T cell lineage. Unlike the situation in normal splenic populations expanded by rIL-2, where the expression of IL-2-R was progressively lost, constitutive expression of high-affinity-IL-2-R was observed in all the lines and thus, this was considered to explain the unlimited proliferation of them in response to rIL-2 alone. These results suggested the probable role of IL-3 in the regulation of growth and differentiation of a set of LGL committed to T cell lineage. The possible

  19. H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation.

    PubMed Central

    Martinelli, R; Heintz, N

    1994-01-01

    H1TF2 is a CCAAT transcription factor that binds to the histone H1 subtype-specific consensus sequence, which has previously been shown to be necessary for temporal regulation of histone H1 transcription during the cell cycle (F. La Bella, P. Gallinari, J. McKinney, and N. Heintz, Genes Dev. 3:1982-1990, 1989). In this study, we report that H1TF2 is a heteromeric CCAAT-binding protein composed of two polypeptide doublets of 33 and 34 kDa and 43 and 44 kDa that are not antigenically related. The 33- and 34-kDa species were not detected in our previous studies (P. Gallinari, F. La Bella, and N. Heintz, Mol. Cell. Biol. 9:1566-1575, 1989) because of technical problems in detection of these heavily glycosylated subunits. The cloning of H1TF2A, the large subunit of this factor, reveals it to be a glutamine-rich protein with extremely limited similarity to previously cloned CCAAT-binding proteins. A monospecific antiserum produced against bacterially synthesized H1TF2A was used to establish that HeLa cell H1TF2A is phosphorylated in vivo and that, in contrast to the H2b transcription factor Oct1 (S. B. Roberts, N. Segil, and N. Heintz, Science 253:1022-1026, 1991; N. Segil, S. B. Roberts, and N. Heintz, Cold Spring Harbor Symp. Quant. Biol. 56:285-292, 1991), no gross change in H1TF2A phosphorylation is evident during the cell cycle. Further immunoprecipitation studies demonstrated that H1TF2 is heterodimeric in the absence of DNA in vivo and identified several H1TF2-interacting proteins that may play a role in H1TF2 function in vivo. Images PMID:7969168

  20. Medical management principles for radiation accidents.

    PubMed

    Meineke, Viktor; van Beuningen, Dirk; Sohns, Torsten; Fliedner, Theodor M

    2003-03-01

    The medical management of radiation accidents requires intensive planning and action. This article looks at the medical management of recent radiation accidents to derive principles for structuring and organizing the treatment of patients who may have radiation-induced health impairments. Although the radiation accidents in Tokai-mura, Japan and Lilo, Georgia were small-scale accidents, they illustrate important and characteristic symptoms and clinical developments. There are lessons to be learned and conclusions to be drawn for the military medical officers concerned with problems of medical management after radiation accidents.

  1. [Determinant factors and conduct in post-accident with biological material among pre-hospital professionals].

    PubMed

    Paiva, Maria Henriqueta Rocha Siqueira; Oliveira, Adriana Cristina

    2011-01-01

    This transversal study was carried out with a multiprofessional team in the pre-hospital care in Minas Gerais, Brazil. It aimed to estimate the incidence of occupational accidents by exposure to biological material and post-accidents conductsta. Descriptive analysis and logistic regression were used. Incidence of accidents was 19.8%: 39,1% perforating-cutting materials and 56.5% body fluids. Doctors (33.3%) and drivers (24.0%) were most involved. Inadequate subsequent measures were highly prevalent: no medical assessment (69.6%), no work accident communication issued (91.3%), no measures (52.2%) and no serological follow-up (52.2%). Variables associated with accidents were: age >31 years old (OR = 3,02; IC95%: 1,25 - 7,33; p = 0,014) and working in basic support units (OR = 5,36; IC95%: 1,51 19,08; p = 0,010). The implementation of post-accidents protocols is suggested in order to reduce accidents and under-notification, and increase post-accident follow-up.

  2. Exploratory analysis of Spanish energetic mining accidents.

    PubMed

    Sanmiquel, Lluís; Freijo, Modesto; Rossell, Josep M

    2012-01-01

    Using data on work accidents and annual mining statistics, the paper studies work-related accidents in the Spanish energetic mining sector in 1999-2008. The following 3 parameters are considered: age, experience and size of the mine (in number of workers) where the accident took place. The main objective of this paper is to show the relationship between different accident indicators: risk index (as an expression of the incidence), average duration index for the age and size of the mine variables (as a measure of the seriousness of an accident), and the gravity index for the various sizes of mines (which measures the seriousness of an accident, too). The conclusions of this study could be useful to develop suitable prevention policies that would contribute towards a decrease in work-related accidents in the Spanish energetic mining industry. PMID:22721539

  3. The Concept of Accident Proneness: A Review

    PubMed Central

    Froggatt, Peter; Smiley, James A.

    1964-01-01

    The term accident proneness was coined by psychological research workers in 1926. Since then its concept—that certain individuals are always more likely than others to sustain accidents, even though exposed to equal risk—has been questioned but seldom seriously challenged. This article describes much of the work and theory on which this concept is based, details the difficulties encountered in obtaining valid information and the interpretative errors that can arise from the examination of imperfect data, and explains why accident proneness became so readily accepted as an explanation of the facts. A recent hypothesis of accident causation, namely that a person's accident liability may vary from time to time, is outlined, and the respective abilities of this and of accident proneness to accord with data from the more reliable literature are examined. The authors conclude that the hypothesis of individual variation in liability is more realistic and in better agreement with the data than is accident proneness. PMID:14106130

  4. [Risk factors for accidents during sports while serving in German armed forces].

    PubMed

    Gundlach, N; Sammito, S; Böckelmann, I

    2012-03-01

    In the German Armed Forces sports activities should bring the benefits of good health and trained fitness which are the hallmarks of sportsmen. In order to achieve this aim it is important to avoid accidents which negate the benefit of sports. Until today there appear to be no studies in existence which demonstrate the risk factors of sports activities undertaken while in military service. Equivalent studies on civilian sport activities are scarcely comparable. To find out risk factors for accidents with any period of recovery we followed sports accidents while on duty in a German barracks with 4,300 soldiers over a two-year period. Additionally we asked about the time needed for recovery from each accident, parameters of lifestyle, the body mass index and the possibility of a nightshift before each accident. We examined a minimum of 410 accidents. We found associations between the accidents studied and particular risk factors, including doing sports more than two times a week, being active in a fitness or sports club, having the accident together with another sportsman and doing a nightshift before the day of the accident. Bad ground conditions contributed to a large number of accidents. A body mass index of 25 and higher had a significantly prolonged time for recovery. To avoid accidents, sport and ground conditions should be adapted to each other. In addition, overweight people are not only compromised for cardiovascular and neurological diseases but also have a higher risk of needing a prolonged time for recovery, thus it is important that overweight should be avoided and not only just be treated.

  5. A multidisciplinary approach to providing care to adolescents with spinal cord trauma resulting from all-terrain vehicle accidents.

    PubMed

    Rhodes, Leslie N; Weatherford, Blakely; Locke, Lindsey N; Chung, Hoi Sing; Tidwell, Chrisla; Paton, Elizabeth; Lee, Shirleatha

    2015-01-01

    All-terrain vehicle accidents that affect the spine can lead to complex injuries in adolescents. This requires that many subspecialties work together on a multidisciplinary team to improve patient outcomes. Our case presentation will examine the multidisciplinary approach to care required for an 11-year-old adolescent involved in an all-terrain vehicle accident that resulted in traumatic spinal cord injury.

  6. Causal Factors and Adverse Events of Aviation Accidents and Incidents Related to Integrated Vehicle Health Management

    NASA Technical Reports Server (NTRS)

    Reveley, Mary S.; Briggs, Jeffrey L.; Evans, Joni K.; Jones, Sharon M.; Kurtoglu, Tolga; Leone, Karen M.; Sandifer, Carl E.

    2011-01-01

    Causal factors in aviation accidents and incidents related to system/component failure/malfunction (SCFM) were examined for Federal Aviation Regulation Parts 121 and 135 operations to establish future requirements for the NASA Aviation Safety Program s Integrated Vehicle Health Management (IVHM) Project. Data analyzed includes National Transportation Safety Board (NSTB) accident data (1988 to 2003), Federal Aviation Administration (FAA) incident data (1988 to 2003), and Aviation Safety Reporting System (ASRS) incident data (1993 to 2008). Failure modes and effects analyses were examined to identify possible modes of SCFM. A table of potential adverse conditions was developed to help evaluate IVHM research technologies. Tables present details of specific SCFM for the incidents and accidents. Of the 370 NTSB accidents affected by SCFM, 48 percent involved the engine or fuel system, and 31 percent involved landing gear or hydraulic failure and malfunctions. A total of 35 percent of all SCFM accidents were caused by improper maintenance. Of the 7732 FAA database incidents affected by SCFM, 33 percent involved landing gear or hydraulics, and 33 percent involved the engine and fuel system. The most frequent SCFM found in ASRS were turbine engine, pressurization system, hydraulic main system, flight management system/flight management computer, and engine. Because the IVHM Project does not address maintenance issues, and landing gear and hydraulic systems accidents are usually not fatal, the focus of research should be those SCFMs that occur in the engine/fuel and flight control/structures systems as well as power systems.

  7. [Characteristics of occupational accidents in the building industry and public works in Senegal].

    PubMed

    Mbaye, I; Fall, M C; Sarr, E H; Ouatara, B; Sow, M L

    2001-01-01

    The objectives of this study were to appreciate the magnitude of work accidents in a building construction sector, to specify their type and characteristics. A retrospective study was undergone in a big building construction industry in Senegal. Data were collected from records of accidents reported to the Social Security Administration between 1994--1996. We looked for characteristics of accidents as well as workers involved in accident. 244 accidents were collected in a three years period, i e 81.5/year, 132 work injuries involved temporaryworkers. 55.73% occurred in chantiers, and 1/3 in working room. Moving and handle objects generated most accidents (36,47%). Wounds and contusions were the most frequent lesion (51,62.%). Arms and feets were concerned in 51.63%, and ocular lesions were noticed in 13.94%. These accidents generate an overall number of 3055 days lost. Work injuries in the building construction sector in Senegal are identical to those described in othercountries. Prevention measures requires improvement of working conditions, education of workers and availability of personal protective equipment's. PMID:15773178

  8. Accident/Mishap Investigation System

    NASA Technical Reports Server (NTRS)

    Keller, Richard; Wolfe, Shawn; Gawdiak, Yuri; Carvalho, Robert; Panontin, Tina; Williams, James; Sturken, Ian

    2007-01-01

    InvestigationOrganizer (IO) is a Web-based collaborative information system that integrates the generic functionality of a database, a document repository, a semantic hypermedia browser, and a rule-based inference system with specialized modeling and visualization functionality to support accident/mishap investigation teams. This accessible, online structure is designed to support investigators by allowing them to make explicit, shared, and meaningful links among evidence, causal models, findings, and recommendations.

  9. Office of Inspector General report on inspection of selected issues regarding the Department of Energy accident investigation program

    SciTech Connect

    1999-04-01

    One method used by the Department of Energy (DOE) to promote worker safety is through the Department`s accident investigation program. The objectives of the program are, among other things, to enhance safety and health of employees, to prevent the recurrence of accidents, and to reduce accident fatality rates and promote a downward trend in the number and severity of accidents. The Assistant Secretary, Office of Environment, Safety and Health (EH), through the EH Office of the Deputy Assistant Secretary for Oversight, is responsible for implementation of the Department`s accident investigation program. As part of the inspection, the authors reviewed an April 1997 EH accident investigation report regarding an accident involving a Lockheed Martin Energy Systems (LMES) welder, who suffered fatal burns when his clothing caught fire while he was using a cutting torch at the Oak Ridge K-25 Site. They also reviewed reports of other accident investigations conducted by EH and DOE field organizations. Based on the review of these reports, the authors identified issues concerning the adequacy of the examination and reporting by accident investigation boards of specific management systems and organizations as a possible accident root cause. The inspection also identified issues concerning worker safety that they determined required immediate management attention, such as whether occurrences were being reported in the appropriate management systems and whether prompt consideration was being given to implementing revisions of national standards when the revisions increased worker safety.

  10. Accident analysis of the windowless target system

    SciTech Connect

    Bianchi, F.; Ferri, R.

    2006-07-01

    Transmutation systems are able to reduce the radio-toxicity and amount of High-Level Wastes (HLW), which are the main concerns related to the peaceful use of nuclear energy, and therefore they should make nuclear energy more easily acceptable by population. A transmutation system consists of a sub-critical fast reactor, an accelerator and a Target System, where the spallation reactions needed to sustain the chain reaction take place. Three options were proposed for the Target System within the European project PDS-XADS (Preliminary Design Studies on an Experimental Accelerator Driven System): window, windowless and solid. This paper describes the constraints taken into account in the design of the windowless Target System for the large Lead-Bismuth-Eutectic cooled XADS and deals with the results of the calculations performed to assess the behaviour of the target during some accident sequences related to pump trips. (authors)

  11. Accident analysis of heavy water cooled thorium breeder reactor

    NASA Astrophysics Data System (ADS)

    Yulianti, Yanti; Su'ud, Zaki; Takaki, Naoyuki

    2015-04-01

    Thorium has lately attracted considerable attention because it is accumulating as a by-product of large scale rare earth mining. The objective of research is to analyze transient behavior of a heavy water cooled thorium breeder that is designed by Tokai University and Tokyo Institute of Technology. That is oxide fueled, PWR type reactor with heavy water as primary coolant. An example of the optimized core has relatively small moderator to fuel volume ratio (MFR) of 0.6 and the characteristics of the core are burn-up of 67 GWd/t, breeding ratio of 1.08, burn-up reactivity loss during cycles of < 0.2% dk/k, and negative coolant reactivity coefficient. One of the nuclear reactor accidents types examined here is Unprotected Transient over Power (UTOP) due to withdrawing of the control rod that result in the positive reactivity insertion so that the reactor power will increase rapidly. Another accident type is Unprotected Loss of Flow (ULOF) that caused by failure of coolant pumps. To analyze the reactor accidents, neutron distribution calculation in the nuclear reactor is the most important factor. The best expression for the neutron distribution is the Boltzmann transport equation. However, solving this equation is very difficult so that the space-time diffusion equation is commonly used. Usually, space-time diffusion equation is solved by employing a point kinetics approach. However, this approach is less accurate for a spatially heterogeneous nuclear reactor and the nuclear reactor with quite large reactivity input. Direct method is therefore used to solve space-time diffusion equation which consider spatial factor in detail during nuclear reactor accident simulation. Set of equations that obtained from full implicit finite-difference method is solved by using iterative methods. The indication of UTOP accident is decreasing macroscopic absorption cross-section that results large external reactivity, and ULOF accident is indicated by decreasing coolant flow. The

  12. Accident analysis of heavy water cooled thorium breeder reactor

    SciTech Connect

    Yulianti, Yanti; Su’ud, Zaki; Takaki, Naoyuki

    2015-04-16

    Thorium has lately attracted considerable attention because it is accumulating as a by-product of large scale rare earth mining. The objective of research is to analyze transient behavior of a heavy water cooled thorium breeder that is designed by Tokai University and Tokyo Institute of Technology. That is oxide fueled, PWR type reactor with heavy water as primary coolant. An example of the optimized core has relatively small moderator to fuel volume ratio (MFR) of 0.6 and the characteristics of the core are burn-up of 67 GWd/t, breeding ratio of 1.08, burn-up reactivity loss during cycles of < 0.2% dk/k, and negative coolant reactivity coefficient. One of the nuclear reactor accidents types examined here is Unprotected Transient over Power (UTOP) due to withdrawing of the control rod that result in the positive reactivity insertion so that the reactor power will increase rapidly. Another accident type is Unprotected Loss of Flow (ULOF) that caused by failure of coolant pumps. To analyze the reactor accidents, neutron distribution calculation in the nuclear reactor is the most important factor. The best expression for the neutron distribution is the Boltzmann transport equation. However, solving this equation is very difficult so that the space-time diffusion equation is commonly used. Usually, space-time diffusion equation is solved by employing a point kinetics approach. However, this approach is less accurate for a spatially heterogeneous nuclear reactor and the nuclear reactor with quite large reactivity input. Direct method is therefore used to solve space-time diffusion equation which consider spatial factor in detail during nuclear reactor accident simulation. Set of equations that obtained from full implicit finite-difference method is solved by using iterative methods. The indication of UTOP accident is decreasing macroscopic absorption cross-section that results large external reactivity, and ULOF accident is indicated by decreasing coolant flow. The

  13. Risk analysis of emergent water pollution accidents based on a Bayesian Network.

    PubMed

    Tang, Caihong; Yi, Yujun; Yang, Zhifeng; Sun, Jie

    2016-01-01

    To guarantee the security of water quality in water transfer channels, especially in open channels, analysis of potential emergent pollution sources in the water transfer process is critical. It is also indispensable for forewarnings and protection from emergent pollution accidents. Bridges above open channels with large amounts of truck traffic are the main locations where emergent accidents could occur. A Bayesian Network model, which consists of six root nodes and three middle layer nodes, was developed in this paper, and was employed to identify the possibility of potential pollution risk. Dianbei Bridge is reviewed as a typical bridge on an open channel of the Middle Route of the South to North Water Transfer Project where emergent traffic accidents could occur. Risk of water pollutions caused by leakage of pollutants into water is focused in this study. The risk for potential traffic accidents at the Dianbei Bridge implies a risk for water pollution in the canal. Based on survey data, statistical analysis, and domain specialist knowledge, a Bayesian Network model was established. The human factor of emergent accidents has been considered in this model. Additionally, this model has been employed to describe the probability of accidents and the risk level. The sensitive reasons for pollution accidents have been deduced. The case has also been simulated that sensitive factors are in a state of most likely to lead to accidents. PMID:26433361

  14. Risk analysis of emergent water pollution accidents based on a Bayesian Network.

    PubMed

    Tang, Caihong; Yi, Yujun; Yang, Zhifeng; Sun, Jie

    2016-01-01

    To guarantee the security of water quality in water transfer channels, especially in open channels, analysis of potential emergent pollution sources in the water transfer process is critical. It is also indispensable for forewarnings and protection from emergent pollution accidents. Bridges above open channels with large amounts of truck traffic are the main locations where emergent accidents could occur. A Bayesian Network model, which consists of six root nodes and three middle layer nodes, was developed in this paper, and was employed to identify the possibility of potential pollution risk. Dianbei Bridge is reviewed as a typical bridge on an open channel of the Middle Route of the South to North Water Transfer Project where emergent traffic accidents could occur. Risk of water pollutions caused by leakage of pollutants into water is focused in this study. The risk for potential traffic accidents at the Dianbei Bridge implies a risk for water pollution in the canal. Based on survey data, statistical analysis, and domain specialist knowledge, a Bayesian Network model was established. The human factor of emergent accidents has been considered in this model. Additionally, this model has been employed to describe the probability of accidents and the risk level. The sensitive reasons for pollution accidents have been deduced. The case has also been simulated that sensitive factors are in a state of most likely to lead to accidents.

  15. Accidents and close call situations connected to the use of mobile phones.

    PubMed

    Korpinen, Leena; Pääkkönen, Rauno

    2012-03-01

    The aim of our work was to study the accidents and close call situations connected to the use of mobile phones. We have analyzed how the accidents/close call situations are connected to background information, in particular age, gender and self-reported symptoms. The study was carried out as a cross-sectional study by posting the questionnaire to 15,000 working-age Finns. The responses (6121) were analyzed using the logistic regression models. Altogether 13.7% of respondents had close call situations and 2.4% had accidents at leisure, in which the mobile phone had a partial effect, and at work the amounts were 4.5% and 0.4% respectively, during the last 12 months. Essentially, we found that: (1) men tend to have more close calls and accidents while on a mobile phone, (2) younger people tend to have more accidents and close calls while on a mobile phone, but it does not appear to be large enough to warrant intervention, (3) employed people tend to have more problems with mobile phone usage and accidents/close calls, and (4) there was a slight increase in mobile-phone-related accidents/close calls if the respondent also reported sleep disturbances and minor aches and pains. In the future, it is important to take into account and study how symptoms can increase the risk of accidents or close call situations in which a mobile phone has a partial effect. PMID:22269487

  16. A traffic accident caused by fatigue failure of axle.

    PubMed

    Park, Chan-Seong; Lee, Sang-Hoon; Lee, Kyu-Jung

    2007-09-01

    An investigation of a traffic accident involving a tractor-trailer and a passenger car that were traveling at high speed is presented. The cause was the fracture of a trailer axle. The investigation showed that the fracture was because of the fatigue failure. In addition, cracks were found in the remaining three trailer wheels. Hardness measurements showed that, because of inadequate heat treatment of the metal, they were prone to failure.

  17. Accident data study of concrete construction companies' similarities and differences between qualified and non-qualified workers in Spain.

    PubMed

    López-Arquillos, Antonio; Rubio-Romero, Juan Carlos; Gibb, Alistair

    2015-01-01

    The aim of this paper is to discuss findings from an analysis of accidents in concrete construction companies in Spain and to compare the accident rates of qualified and non-qualified workers. A total of 125,021 accidents between 2003 and 2008 involving both blue-collar and white-collar workers were analysed, comparing the variables of occupation, age, company staff, length of service, location of the accident, together with the severity of the accidents. Results showed that lack of experience in the first month is more significant in non-qualified workers and experienced supervisors and that head injuries are more likely to lead to fatalities. The most remarkable similarity was that fatal accidents to and from the worksite are a problem common to both groups of workers.

  18. [Mortality due to bicycle accidents in Pernambuco, Brazil].

    PubMed

    Galvão, Pauliana Valéria Machado; Pestana, Luciana Pinto; Pestana, Valter Mário; Spíndola, Michelline Oliveira Pedrosa; Campello, Reginaldo Inojosa Carneiro; de Souza, Eliane Helena Alvim

    2013-05-01

    The scope of this paper was to conduct a quantitative analysis of deaths resulting from bicycle accidents in the state of Pernambuco by studying secondary data between 2001 and 2010. The sample consisted of all the Deaths recorded in the Mortality Information System of the Unified Health System Database that reported bicycle accidents between 2001 and 2010. Descriptive measures were determined for all variables. Socio-demographic variables were paired with the basic cause of death in order to find a statistical correlation. In Pernambuco, the aforementioned information system recorded 517 deaths resulting from bicycle accidents, with greater frequency in men between 25 and 59 years of age, Afro-Brazilians, single and of unknown schooling. The mean age was 36.82 years (SD = 17.026), and the minimum and maximum age of 4 and 86 years old, respectively. The findings highlight the need for the creation of adequate infrastructure and effective legal measures to prevent traffic accidents involving this type of vehicle, relying on the evidence of distribution of cases in most Pernambuco municipalities.

  19. Estimation of Explosion Energy Yield at Chernobyl NPP Accident

    NASA Astrophysics Data System (ADS)

    Pakhomov, Sergey A.; Dubasov, Yuri V.

    2010-05-01

    The value of the 133Xe/133mXe isometric activity ratio for the stationary regime of reactor work is about 35, and that for an instant fission (explosion) is about 11, which allowed estimation of the nuclear component of the instant (explosion) energy release during the NPP accident. Atmospheric xenon samples were taken at the trajectory of accident product transfers (in the Cherepovetz area); these samples were measured by a gamma spectrometer, and the 133Xe/133mXe ratio was determined as an average value of 22.4. For estimations a mathematic model was elaborated considering both the value of instant released energy and the schedule of reactor power change before the accident, as well as different fractionation conditions on the isobaric chain. Comparison of estimated results with the experimental data showed the value of the instant specific energy release in the Chernobyl NPP accident to be 2·105-2·106 J/Wt or 6·1014-6·1015 J (100-1,000 kt). This result is matched up to a total reactor power of 3,200 MWt. However this estimate is not comparable with the actual explosion scale estimated as 10t TNT. This suggests a local character of the instant nuclear energy release and makes it possible to estimate the mass of fuel involved in this explosion process to be from 0.01 to 0.1% of total quantity.

  20. On Involvement.

    ERIC Educational Resources Information Center

    Greene, Michael B.

    Involvement Ratings In Settings (IRIS), a multi-dimensional non-verbal scale of involvement adaptable to a time-sampling method of data collection, was constructed with the aid of the videotapes of second-grade Follow Through classrooms made by CCEP. Scales were defined through observations of involved and alienated behavior, and the IRIS was…

  1. Genitalia burn: accident or violence? Concerns that transcend injury treatment

    PubMed Central

    Ferreira, Ana Lúcia; Ferreira, Juliana Montez; da Silva, Paula Marques C.; Constancio, Dilene Francisco

    2014-01-01

    OBJECTIVE: To describe a case of genital burn which raised the suspicion of maltreatment (sexual abuse and neglect by lack of supervision). CASE DESCRIPTION: An infant was taken to the Emergency Room of a pediatric hospital with an extensive burn in the vulva and perineum. The mother claimed the burn had been caused by a sodium-hydroxide-based product. However, the injury severity led to the suspicion of sexual abuse, which was then ruled out by a multidisciplinary team, based on the consistent report by the mother. Besides, the lesion type matched those caused by the chemical agent involved in the accident and the family context was evaluated and considered adequate. The patient had a favorable outcome and was discharged after four days of hospitalization. Outpatient follow-up during six months after the accident enabled the team to rule out neglect by lack of supervision. COMMENTS: Accidents and violence are frequent causes of physical injuries in children, and the differential diagnosis between them can be a challenge for healthcare workers, especially in rare clinical conditions involving patients who cannot speak for themselves. The involvement of a multidisciplinary trained team helps to have an adequate approach, ensuring child protection and developing a bond with the family; the latter is essential for a continued patient follow-up. PMID:25119763

  2. Temporal Statistic of Traffic Accidents in Turkey

    NASA Astrophysics Data System (ADS)

    Erdogan, S.; Yalcin, M.; Yilmaz, M.; Korkmaz Takim, A.

    2015-10-01

    Traffic accidents form clusters in terms of geographic space and over time which themselves exhibit distinct spatial and temporal patterns. There is an imperative need to understand how, where and when traffic accidents occur in order to develop appropriate accident reduction strategies. An improved understanding of the location, time and reasons for traffic accidents makes a significant contribution to preventing them. Traffic accident occurrences have been extensively studied from different spatial and temporal points of view using a variety of methodological approaches. In literature, less research has been dedicated to the temporal patterns of traffic accidents. In this paper, the numbers of traffic accidents are normalized according to the traffic volume and the distribution and fluctuation of these accidents is examined in terms of Islamic time intervals. The daily activities and worship of Muslims are arranged according to these time intervals that are spaced fairly throughout the day according to the position of the sun. The Islamic time intervals are never been used before to identify the critical hour for traffic accidents in the world. The results show that the sunrise is the critical time that acts as a threshold in the rate of traffic accidents throughout Turkey in Islamic time intervals.

  3. Guidelines for Exposure Assessment in Health Risk Studies Following a Nuclear Reactor Accident

    PubMed Central

    Bouville, André; Linet, Martha S.; Hatch, Maureen; Mabuchi, Kiyohiko

    2013-01-01

    Background: Worldwide concerns regarding health effects after the Chernobyl and Fukushima nuclear power plant accidents indicate a clear need to identify short- and long-term health impacts that might result from accidents in the future. Fundamental to addressing this problem are reliable and accurate radiation dose estimates for the affected populations. The available guidance for activities following nuclear accidents is limited with regard to strategies for dose assessment in health risk studies. Objectives: Here we propose a comprehensive systematic approach to estimating radiation doses for the evaluation of health risks resulting from a nuclear power plant accident, reflected in a set of seven guidelines. Discussion: Four major nuclear reactor accidents have occurred during the history of nuclear power production. The circumstances leading to these accidents were varied, as were the magnitude of the releases of radioactive materials, the pathways by which persons were exposed, the data collected afterward, and the lifestyle factors and dietary consumption that played an important role in the associated radiation exposure of the affected populations. Accidents involving nuclear reactors may occur in the future under a variety of conditions. The guidelines we recommend here are intended to facilitate obtaining reliable dose estimations for a range of different exposure conditions. We recognize that full implementation of the proposed approach may not always be feasible because of other priorities during the nuclear accident emergency and because of limited resources in manpower and equipment. Conclusions: The proposed approach can serve as a basis to optimize the value of radiation dose reconstruction following a nuclear reactor accident. Citation: Bouville A, Linet MS, Hatch M, Mabuchi K, Simon SL. 2014. Guidelines for exposure assessment in health risk studies following a nuclear reactor accident. Environ Health Perspect 122:1–5; http://dx.doi.org/10

  4. Cellular automata model simulating traffic car accidents in the on-ramp system

    NASA Astrophysics Data System (ADS)

    Echab, H.; Lakouari, N.; Ez-Zahraouy, H.; Benyoussef, A.

    2015-01-01

    In this paper, using Nagel-Schreckenberg model we study the on-ramp system under the expanded open boundary condition. The phase diagram of the two-lane on-ramp system is computed. It is found that the expanded left boundary insertion strategy enhances the flow in the on-ramp lane. Furthermore, we have studied the probability of the occurrence of car accidents. We distinguish two types of car accidents: the accident at the on-ramp site (Prc) and the rear-end accident in the main road (Pac). It is shown that car accidents at the on-ramp site are more likely to occur when traffic is free on road A. However, the rear-end accidents begin to occur above a critical injecting rate αc1. The influence of the on-ramp length (LB) and position (xC0) on the car accidents probabilities is studied. We found that large LB or xC0 causes an important decrease of the probability Prc. However, only large xC0 provokes an increase of the probability Pac. The effect of the stochastic randomization is also computed.

  5. Road rage and road traffic accidents among commercial vehicle drivers in Lahore, Pakistan.

    PubMed

    Shaikh, M A; Shaikh, I A; Siddiqui, Z

    2012-04-01

    Road rage and road traffic accidents increase the burden of morbidity and mortality in a population. A cross-sectional survey with convenience sampling was conducted among commercial vehicle drivers in Lahore, Pakistan (n = 901) to record their behaviours/experiences regarding road rage and road traffic accidents. Respondents were asked about incidents of shouting/cursing/rude gestures or threats to physically hurt the person/vehicle, by others or themselves, in the previous 24 hours or 3 months, and their involvement in road traffic accidents in the previous 12 months. Auto-rickshaw drivers were significantly more likely to report various road rage experiences/behaviours and involvement in accidents compared with bus and wagon drivers. A total of 112 respondents (12.4%) reported being involved in a road traffic accident in the previous 12 months but traffic police did not record the accident in 52.7% of cases. The results of this study underline the need to improve road safety in Pakistan.

  6. Industrial accidents are related to relative body weight: the Israeli CORDIS study.

    PubMed Central

    Froom, P; Melamed, S; Kristal-Boneh, E; Gofer, D; Ribak, J

    1996-01-01

    OBJECTIVES: The accident rate might be influenced by intrinsic characteristics of the workers, by risks inherent in the work environment, or a combination of these factors. As increased weight may be associated with sleep disturbances and fatigue, a high body mass index (BMI) might be an independent risk factor for accidents in industrial workers. METHODS: 3801 men were examined and followed up for two years for the occurrence of accidents. The objective environmental conditions were recorded and translated into a single score of ergonomic stress levels. Height and weight were recorded, as were possible confounding factors including measures of fatigue, type A personality, total night time sleep, job satisfaction, somatic complaints, smoking, and education levels. RESULTS: Both BMI and ergonomic stress levels independently predicted involvement in accidents (two or more) with those in the highest BMI quartile who worked in an environment with high ergonomic stress levels having a 4-6 times increased risk of accidents compared with those in the lowest BMI quartile who worked in an environment with low ergonomic stress levels (95% confidence interval (95% CI) 2.4-9.0, P < 0.001). Although increasing somatic complaints and a low educational level also were predictors of accidents, they did not mediate the effect of the BMI on the accident rate. Increasing age, less smoking, and decreased sleep hours were significantly associated with an increased BMI, but the association of BMI and involvement in accidents also could not be explained by those factors or the other confounders. CONCLUSIONS: BMI independently influences the accident rate. Further studies warranted to confirm these findings and to explore mechanisms supporting biological plausibility. PMID:9004929

  7. Distribution of Causes in Selected US Aviation Accident Reports Between 1996 and 2003

    NASA Technical Reports Server (NTRS)

    Holloway, C. M.; Johnson, C. W.

    2004-01-01

    This paper describes the results of an independent analysis of the probable and contributory causes of selected aviation accidents in the United States between 1996 and 2003. The purpose of the study was to assess the comparative frequency of a variety of causal factors in the reporting of these adverse events. Although our results show that more of these high consequence accidents were attributed to human error than to any other single factor, a large number of reports also mentioned wider systemic issues, including the managerial and regulatory context of aviation operations. These wider issues are more likely to appear as contributory rather than primary causes in this set of accident reports.

  8. MSHA releases data on CM crushing accidents

    SciTech Connect

    2007-02-15

    The US Mine Safety and Health Administration (MHSA) recently formed a committee to identify norms and trends in remote control continuous miner crushing accidents. The final report found that these types of accidents commonly happen to experienced miners during routine mining activities, with the majority occurring while moving the miner from one face to another, place changing. Another common aspect of the accidents is that many of the victims are experienced miners who are newly employed at the mine where the accident occurred. Training all employees to stay outside the turning radius of an energized remote control continuous miner, establishing this as a safe operating procedure, and consistently enforcing this practice among miners will reduce these types of accidents. This article was excerpted from the 'Remote Control Continuous Mining Machine Crushing Accident Data Study' published in May 2006. The report may be found from the website: www.msha.gov. 4 figs., 1 tab.

  9. Estimation Of 137Cs Using Atmospheric Dispersion Models After A Nuclear Reactor Accident

    NASA Astrophysics Data System (ADS)

    Simsek, V.; Kindap, T.; Unal, A.; Pozzoli, L.; Karaca, M.

    2012-04-01

    Nuclear energy will continue to have an important role in the production of electricity in the world as the need of energy grows up. But the safety of power plants will always be a question mark for people because of the accidents happened in the past. Chernobyl nuclear reactor accident which happened in 26 April 1986 was the biggest nuclear accident ever. Because of explosion and fire large quantities of radioactive material was released to the atmosphere. The release of the radioactive particles because of accident affected not only its region but the entire Northern hemisphere. But much of the radioactive material was spread over west USSR and Europe. There are many studies about distribution of radioactive particles and the deposition of radionuclides all over Europe. But this was not true for Turkey especially for the deposition of radionuclides released after Chernobyl nuclear reactor accident and the radiation doses received by people. The aim of this study is to determine the radiation doses received by people living in Turkish territory after Chernobyl nuclear reactor accident and use this method in case of an emergency. For this purpose The Weather Research and Forecasting (WRF) Model was used to simulate meteorological conditions after the accident. The results of WRF which were for the 12 days after accident were used as input data for the HYSPLIT model. NOAA-ARL's (National Oceanic and Atmospheric Administration Air Resources Laboratory) dispersion model HYSPLIT was used to simulate the 137Cs distrubition. The deposition values of 137Cs in our domain after Chernobyl Nuclear Reactor Accident were between 1.2E-37 Bq/m2 and 3.5E+08 Bq/m2. The results showed that Turkey was affected because of the accident especially the Black Sea Region. And the doses were calculated by using GENII-LIN which is multipurpose health physics code.

  10. Cardiac damage presenting late after road accidents.

    PubMed Central

    Mackintosh, A F; Fleming, H A

    1981-01-01

    Six examples of cardiac damage secondary to non-penetrating trauma in road accidents are described. In all six cases the lesion was not recognised at the time of the accident but became clinically important two days to 17 years later. As the patients were young or had unusual lesions, the damage could be attributed to the accident. In older patients with common cardiac problems the trauma might not be recognised as the underlying cause. PMID:7330802

  11. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect

    Ryan, G.W., Westinghouse Hanford

    1996-07-12

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  12. Industrial Safety and Accidents Prevention

    SciTech Connect

    Sajjad Akbar

    2006-07-01

    Accident Hazards, dangers, losses and risk are what we would to like to eliminate, minimize or avoid in industry. Modern industries have created many opportunities for these against which man's primitive instincts offer no protection. In today's complex industrial environment safety has become major preoccupation, especially after the realization that there is a clear economic incentive to do so. Industrial hazards may cause by human error or by physical or mechanical malfunction, it is very often possible to eliminate the worst consequences of human error by engineering modification. But the modification also needs checking very thoroughly to ensue that it has not introduced some new and unsuspected hazard. (author)

  13. HTGR severe accident sequence analysis

    SciTech Connect

    Harrington, R.M.; Ball, S.J.; Kornegay, F.C.

    1982-01-01

    Thermal-hydraulic, fission product transport, and atmospheric dispersion calculations are presented for hypothetical severe accident release paths at the Fort St. Vrain (FSV) high temperature gas cooled reactor (HTGR). Off-site radiation exposures are calculated for assumed release of 100% of the 24 hour post-shutdown core xenon and krypton inventory and 5.5% of the iodine inventory. The results show conditions under which dose avoidance measures would be desirable and demonstrate the importance of specific release characteristics such as effective release height. 7 tables.

  14. The determinants of fishing vessel accident severity.

    PubMed

    Jin, Di

    2014-05-01

    The study examines the determinants of fishing vessel accident severity in the Northeastern United States using vessel accident data from the U.S. Coast Guard for 2001-2008. Vessel damage and crew injury severity equations were estimated separately utilizing the ordered probit model. The results suggest that fishing vessel accident severity is significantly affected by several types of accidents. Vessel damage severity is positively associated with loss of stability, sinking, daytime wind speed, vessel age, and distance to shore. Vessel damage severity is negatively associated with vessel size and daytime sea level pressure. Crew injury severity is also positively related to the loss of vessel stability and sinking.

  15. Thermal hydraulic features of the TMI accident

    NASA Astrophysics Data System (ADS)

    Tolman, B.

    1985-10-01

    The Three Mile island (TMI)-2 accident resulted in extensive core damage and recent data confirms that the reactor vessel was challenged from molten core materials. A hypothesized TMI accident scenario is presented that consistently explains the TMI data and is also consistent with research findings from independent severe fuel damage experiments. The TMI data will prove useful in confirming our understanding of severe core damage accidents under realistic reactor systems conditions. This understanding will aid in addressing safety and regulatory issues related to severe core damage accidents in light water reactors.

  16. Aircraft Loss-of-Control Accident Analysis

    NASA Technical Reports Server (NTRS)

    Belcastro, Christine M.; Foster, John V.

    2010-01-01

    Loss of control remains one of the largest contributors to fatal aircraft accidents worldwide. Aircraft loss-of-control accidents are complex in that they can result from numerous causal and contributing factors acting alone or (more often) in combination. Hence, there is no single intervention strategy to prevent these accidents. To gain a better understanding into aircraft loss-of-control events and possible intervention strategies, this paper presents a detailed analysis of loss-of-control accident data (predominantly from Part 121), including worst case combinations of causal and contributing factors and their sequencing. Future potential risks are also considered.

  17. [SAFETY IN THE ELDERLY: HOME ACCIDENTS].

    PubMed

    Martín-Espinosa, Noelia M; Píriz-Campos, Rosa Ma; Cordeiro, Raú; Muñoz Bermejo, Laura; Casado Verdjo, Inés; Postigo Mota, Salvador

    2016-05-01

    Home accidents are more common in the elderly and they can have serious consequences to the injured person's health. At home, chances to suffer accidents of any type are higher, because it's the place where old people spend most of their daily time. It is important to point out that a high percentage of domestic accidents could be easily avoided by taking some simple cautions. The main aim of this paper is to know how we can prevent most common domestic accidents in the aged population: falls, burnings, poisonings and fire prevention. PMID:27405149

  18. The determinants of fishing vessel accident severity.

    PubMed

    Jin, Di

    2014-05-01

    The study examines the determinants of fishing vessel accident severity in the Northeastern United States using vessel accident data from the U.S. Coast Guard for 2001-2008. Vessel damage and crew injury severity equations were estimated separately utilizing the ordered probit model. The results suggest that fishing vessel accident severity is significantly affected by several types of accidents. Vessel damage severity is positively associated with loss of stability, sinking, daytime wind speed, vessel age, and distance to shore. Vessel damage severity is negatively associated with vessel size and daytime sea level pressure. Crew injury severity is also positively related to the loss of vessel stability and sinking. PMID:24473412

  19. [Medicolegal and compensation scientific approach to automobile accident].

    PubMed

    Yamanouchi, Haruo

    2002-09-01

    Multiple injuries are frequently observed over the whole body of traffic victims in medico-legal autopsy cases. The assessment of a traffic casualty must include not only the victim but also the vehicle and the circumstances of the accident. Only consideration of all available data permits a better assessment of the mechanism of the crash and causation of injuries. J. M. Thevenet drove the first car carried from France to Japan on February 6, 1898. On October 28th, 1905, the first death by a road traffic accident occurred in Osaka. We performed a retrospective analysis of 279 traffic fatalities examined by medico-legal autopsy in Niigata that occurred over a twenty-two-year period from 1980 to 2001. All persons who had an ICD-10 code were grouped by 153 pedestrians, 43 pedal cyclists, 20 motorcycle riders, 45 car occupants, 11 occupants of pick-up trucks or vans, 4 occupants of heavy transport vehicles and 3 others. The average of ISS (injury scale score) is 40.7 in pedestrians, 26.7 in pedal cyclists, 32.4 in motorcycle riders, 25.1 in car occupants, 16.5 in occupants of pick-up trucks or vans, 24.0 in heavy transport vehicles and 69.0 in others. Rib fractures were observed in 170 cases (60.9%) and the frequency of other injuries was shown in Table 2. Criminal Punishment for drivers involved in 261 traffic accidents amounted to 35 sentences of imprisonment (13.4%), 46 suspension of execution of sentence (17.6%) and 60 sentence of fine (23.0%). Forty prone pedestrians run over by cars showed high ethanol levels in their blood. It was necessary to identify the driver of a vehicle in twelve car accidents and simulation with a computer is very useful. The average of ISS was 34.0 in ten drivers and 22.0 in fourteen fellow passengers. Four sudden natural deaths of drivers at the wheel, eight cases of death immediately after and from one day to five months after road traffic accidents, nine suicides and one intentional accident are excluded from traffic death. Both a

  20. [Medicolegal and compensation scientific approach to automobile accident].

    PubMed

    Yamanouchi, Haruo

    2002-09-01

    Multiple injuries are frequently observed over the whole body of traffic victims in medico-legal autopsy cases. The assessment of a traffic casualty must include not only the victim but also the vehicle and the circumstances of the accident. Only consideration of all available data permits a better assessment of the mechanism of the crash and causation of injuries. J. M. Thevenet drove the first car carried from France to Japan on February 6, 1898. On October 28th, 1905, the first death by a road traffic accident occurred in Osaka. We performed a retrospective analysis of 279 traffic fatalities examined by medico-legal autopsy in Niigata that occurred over a twenty-two-year period from 1980 to 2001. All persons who had an ICD-10 code were grouped by 153 pedestrians, 43 pedal cyclists, 20 motorcycle riders, 45 car occupants, 11 occupants of pick-up trucks or vans, 4 occupants of heavy transport vehicles and 3 others. The average of ISS (injury scale score) is 40.7 in pedestrians, 26.7 in pedal cyclists, 32.4 in motorcycle riders, 25.1 in car occupants, 16.5 in occupants of pick-up trucks or vans, 24.0 in heavy transport vehicles and 69.0 in others. Rib fractures were observed in 170 cases (60.9%) and the frequency of other injuries was shown in Table 2. Criminal Punishment for drivers involved in 261 traffic accidents amounted to 35 sentences of imprisonment (13.4%), 46 suspension of execution of sentence (17.6%) and 60 sentence of fine (23.0%). Forty prone pedestrians run over by cars showed high ethanol levels in their blood. It was necessary to identify the driver of a vehicle in twelve car accidents and simulation with a computer is very useful. The average of ISS was 34.0 in ten drivers and 22.0 in fourteen fellow passengers. Four sudden natural deaths of drivers at the wheel, eight cases of death immediately after and from one day to five months after road traffic accidents, nine suicides and one intentional accident are excluded from traffic death. Both a

  1. Application of a human error framework to conduct train accident/incident investigations.

    PubMed

    Reinach, Stephen; Viale, Alex

    2006-03-01

    Accident/incident investigations are an important qualitative approach to understanding and managing transportation safety. To better understand potential safety implications of recently introduced remote control locomotive (RCL) operations in railroad yard switching, researchers investigated six railroad accidents/incidents. To conduct the investigations, researchers first modified the human factors analysis and classification system (HFACS) to optimize its applicability to the railroad industry (HFACS-RR) and then developed accident/incident data collection and analysis tools based on HFACS-RR. A total of 36 probable contributing factors were identified among the six accidents/incidents investigated. Each accident/incident was associated with multiple contributing factors, and, for each accident/incident, active failures and latent conditions were identified. The application of HFACS-RR and a theoretically driven approach to investigating accidents/incidents involving human error ensured that all levels of the system were considered during data collection and analysis phases of the investigation and that investigations were systematic and thorough. Future work is underway to develop a handheld software tool that incorporates these data collection and analysis tools.

  2. The Chernobyl accident 20 years on: an assessment of the health consequences and the international response.

    PubMed

    Baverstock, Keith; Williams, Dillwyn

    2007-01-01

    Twenty years after the Chernobyl accident the WHO and the International Atomic Energy Authority issued a reassuring statement about the consequences. Our objectives in this study were to evaluate the health impact of the Chernobyl accident, assess the international response to the accident, and consider how to improve responses to future accidents. So far, radiation to the thyroid from radioisotopes of iodine has caused several thousand cases of thyroid cancer but very few deaths; exposed children were most susceptible. The focus on thyroid cancer has diverted attention from possible nonthyroid effects. The international response to the accident was inadequate and uncoordinated, and has been unjustifiably reassuring. Accurate assessment in future health effects is not currently possible in the light of dose uncertainties, current debates over radiation actions, and the lessons from the late consequences of atomic bomb exposure. Because of the uncertainties from and the consequences of the accident, it is essential that investigations of its effects should be broadened and supported for the long term. The United Nations should initiate an independent review of the actions and assignments of the agencies concerned, with recommendations for dealing with future international-scale accidents. These should involve independent scientists and ensure cooperation rather than rivalry. PMID:17680126

  3. Hazards to children in traffic. A paediatrician looks at road accidents.

    PubMed Central

    Jackson, R H

    1978-01-01

    An overall view is presented of the hazards to children in traffic. The importance of the developmental aspects of childhood accidents is stressed, and a plea is made for doctors working with children to recognise the part they could play in reducing the number of road accidents to children by their understanding of child development and behaviour. It is an aspect of preventive paediatrics that is largely neglected at present. PMID:727795

  4. Decreasing number of young licence holders and reduced number of accidents. A description of trends in Sweden.

    PubMed

    Murray, Asa

    2003-11-01

    The following study compares rates of licence holders and rates of car accidents in two age cohorts born in Sweden in 1972 and 1977, respectively. The research material consists of all accidents with injury which these young people have been involved in as car drivers at age 16-21. The periods concerned are 1988-1993 and 1993-1998, respectively. In the respective periods altogether 2082 and 1453 car accidents leading to injury were recorded. The results show a lower rate of licence holders and a lower rate of car accidents in the later age cohort. Particularly the rate of fatal accidents and accidents leading to serious injury was lower. Comparing the earlier with the later age cohort, the reduction of accidents was greatest in the most densely built-up counties of Sweden and in the groups with the highest risk, namely those age and socio-economic groups who had the highest rate of fatalities and accidents leading to serious injury. Factors behind the decrease in the rates of licence holders and the rates of car accidents are discussed. Recession in the economy and less interest in car driving among young people are factors which are suggested as explanations.

  5. Relationship between Recent Flight Experience and Pilot Error General Aviation Accidents

    NASA Astrophysics Data System (ADS)

    Nilsson, Sarah J.

    Aviation insurance agents and fixed-base operation (FBO) owners use recent flight experience, as implied by the 90-day rule, to measure pilot proficiency in physical airplane skills, and to assess the likelihood of a pilot error accident. The generally accepted premise is that more experience in a recent timeframe predicts less of a propensity for an accident, all other factors excluded. Some of these aviation industry stakeholders measure pilot proficiency solely by using time flown within the past 90, 60, or even 30 days, not accounting for extensive research showing aeronautical decision-making and situational awareness training decrease the likelihood of a pilot error accident. In an effort to reduce the pilot error accident rate, the Federal Aviation Administration (FAA) has seen the need to shift pilot training emphasis from proficiency in physical airplane skills to aeronautical decision-making and situational awareness skills. However, current pilot training standards still focus more on the former than on the latter. The relationship between pilot error accidents and recent flight experience implied by the FAA's 90-day rule has not been rigorously assessed using empirical data. The intent of this research was to relate recent flight experience, in terms of time flown in the past 90 days, to pilot error accidents. A quantitative ex post facto approach, focusing on private pilots of single-engine general aviation (GA) fixed-wing aircraft, was used to analyze National Transportation Safety Board (NTSB) accident investigation archival data. The data were analyzed using t-tests and binary logistic regression. T-tests between the mean number of hours of recent flight experience of tricycle gear pilots involved in pilot error accidents (TPE) and non-pilot error accidents (TNPE), t(202) = -.200, p = .842, and conventional gear pilots involved in pilot error accidents (CPE) and non-pilot error accidents (CNPE), t(111) = -.271, p = .787, indicate there is no

  6. Estimating cost ratio distribution between fatal and non-fatal road accidents in Malaysia

    NASA Astrophysics Data System (ADS)

    Hamdan, Nurhidayah; Daud, Noorizam

    2014-07-01

    Road traffic crashes are a global major problem, and should be treated as a shared responsibility. In Malaysia, road accident tragedies kill 6,917 people and injure or disable 17,522 people in year 2012, and government spent about RM9.3 billion in 2009 which cost the nation approximately 1 to 2 percent loss of gross domestic product (GDP) reported annually. The current cost ratio for fatal and non-fatal accident used by Ministry of Works Malaysia simply based on arbitrary value of 6:4 or equivalent 1.5:1 depends on the fact that there are six factors involved in the calculation accident cost for fatal accident while four factors for non-fatal accident. The simple indication used by the authority to calculate the cost ratio is doubted since there is lack of mathematical and conceptual evidence to explain how this ratio is determined. The main aim of this study is to determine the new accident cost ratio for fatal and non-fatal accident in Malaysia based on quantitative statistical approach. The cost ratio distributions will be estimated based on Weibull distribution. Due to the unavailability of official accident cost data, insurance claim data both for fatal and non-fatal accident have been used as proxy information for the actual accident cost. There are two types of parameter estimates used in this study, which are maximum likelihood (MLE) and robust estimation. The findings of this study reveal that accident cost ratio for fatal and non-fatal claim when using MLE is 1.33, while, for robust estimates, the cost ratio is slightly higher which is 1.51. This study will help the authority to determine a more accurate cost ratio between fatal and non-fatal accident as compared to the official ratio set by the government, since cost ratio is an important element to be used as a weightage in modeling road accident related data. Therefore, this study provides some guidance tips to revise the insurance claim set by the Malaysia road authority, hence the appropriate method

  7. ARGX-87: Accident Response Group Exercise, 1987: A Broken Arrow mini exercise. [Training

    SciTech Connect

    Schuld, E.P.; Cruff, D.F.

    1987-07-01

    A Broken Arrow mini exercise dubbed ''Accident Response Group Exercise - 1987'' (ARGX-87) was conducted on June 1, 1987 at the Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories, Livermore (SNLL). The exercise started at 0445 PDT with a call from the Department of Energy (DOE) - EOC in Washington, DC, to the Albuquerque Operations (AL - ) - EOC. AL, in turn, called the Laboratory off-hour emergency number (Fire Dispatcher), who called the Laboratory Emergency Duty Officer (LEDO). The LEDO then contacted the Accident Response Group (ARG) Senior Scientific Advisor. Calls were placed to assemble appropriate members of the ARG in the ALERT Center. No phone number for SNLL was available at the Albuquerque Operations EOC, so a controller injected a message to SNLL to get them involved in the exercise. The messages received at the Laboratory identified the Air Force line item weapon system involved in the accident and the accident location. As people arrived at the ALERT Center they began discussing the details of the accident. They also started working the deployment logistics and other issues. Travel arrangements for the HOT SPOT equipment and ARG personnel were made for immediate deployment to the accident site in North Dakota. The exercise was terminated at 0840 as planned. While certain procedural deficiencies were noted, the exercise was considered a valuable learning experience. The results and observations from this experience will be used to refine the operating procedures and the training program.

  8. Accident investigation reporting deficiencies related to organizational factors in machinery space fires and explosions.

    PubMed

    Schröder-Hinrichs, Jens U; Baldauf, Michael; Ghirxi, Kevin T

    2011-05-01

    Careful accident investigation provides opportunities to review safety arrangements in socio-technical systems. There is consensus that human intervention is involved in the majority of accidents. Ever cautious of the consequences attributed to such a claim vis-à-vis the apportionment of blame, several authors have highlighted the importance of investigating organizational factors in this respect. Specific regulations to limit what were perceived as unsuitable organizational influences in shipping operations were adopted by the International Maritime Organization (IMO). Guidance is provided for the investigation of human and organizational factors involved in maritime accidents. This paper presents a review of 41 accident investigation reports related to machinery space fires and explosions. The objective was to find out if organizational factors are identified during maritime accident investigations. An adapted version of the Human Factor Analysis and Classification System (HFACS) with minor modifications related to machinery space features was used for this review. The results of the review show that organizational factors were not identified by maritime accident investigators to the extent expected had the IMO guidelines been observed. Instead, contributing factors at the lower end of organizational echelons are over-represented. PMID:21376918

  9. Overview: cerebrovascular accident and the hospitalized elderly--a multidimensional clinical problem.

    PubMed

    Goodstein, R K

    1983-02-01

    A cerebrovascular accident is unwelcome at any age, but for the elderly it involves concerns. The abrupt onset of a cerebrovascular accident signals anew the already present fears of loss of control, death, insanity, disfigurement, loss of physical function, and sexual impairment. The accident can also result in worry about the possibility of explosive recurrence, disruption of thoughts and emotions, lengthy treatment away from home, and exhaustion of retirement funds. Therapeutic endeavors must be eclectic and individually tailored to address the special needs of the elderly patient, the highly technical and diverse health care team, the worried family, and the depression, delirium, and subtle clinical syndromes manifesting as poor patient motivation that often accompany a cerebrovascular accident.

  10. [Myocardial infarction as work-related accident: medical and legal problems].

    PubMed

    Szozda, Ryszard; Procek, Marek

    2002-01-01

    An accident is a work-related event caused by an external factor. Therefore, myocardial infarction is also considered, in specific conditions, as a work-related accident. The aim of this study was to present the cause-effect relationship between myocardial infarction and working conditions in the context of a work-related accident characterized by: urgency of event, external factor and relation with working conditions. The attitude of the Supreme Court to the question of certification, highlighting the key issues and facilitating the understanding of the problem and opinions of legal experts on this matter is also discussed. Myocardial infarction as a work-related accident is an issue involving both law and medicine, particularly occupational medicine, that will have to tackle and solve this problem in its several dimensions, including periodical examinations.

  11. Overview of BWR Severe Accident Sequence Analyses at Oak Ridge National Laboratory

    SciTech Connect

    Hodge, S.A.

    1983-01-01

    Since its inception in October 1980, the Severe Accident Sequence Analysis (SASA) program at Oak Ridge National Laboratory (ORNL) has completed four studies including Station Blackout, Scram Discharge Volume Break, Loss of Decay Heat Removal, and Loss of Injection accident sequences for the Browns Ferry Nuclear Plant. The accident analyses incorporated in a SASA study provide much greater detail than that practically achievable in a Probabilistic Risk Assessment (PRA). When applied to the candidate dominant accident sequences identified by a PRA, the detailed SASA results determine if factors neglected by the PRA would have a significant effect on the order of dominant sequences. Ongoing SASA work at ORNL involves the analysis of Anticipated Transients Without Scram (ATWS) sequences for Browns Ferry.

  12. Key factors contributing to accident severity rate in construction industry in Iran: a regression modelling approach.

    PubMed

    Soltanzadeh, Ahmad; Mohammadfam, Iraj; Moghimbeigi, Abbas; Ghiasvand, Reza

    2016-03-01

    Construction industry involves the highest risk of occupational accidents and bodily injuries, which range from mild to very severe. The aim of this cross-sectional study was to identify the factors associated with accident severity rate (ASR) in the largest Iranian construction companies based on data about 500 occupational accidents recorded from 2009 to 2013. We also gathered data on safety and health risk management and training systems. Data were analysed using Pearson's chi-squared coefficient and multiple regression analysis. Median ASR (and the interquartile range) was 107.50 (57.24- 381.25). Fourteen of the 24 studied factors stood out as most affecting construction accident severity (p<0.05). These findings can be applied in the design and implementation of a comprehensive safety and health risk management system to reduce ASR. PMID:27092639

  13. Impact of gender, age and experience of pilots on general aviation accidents.

    PubMed

    Bazargan, Massoud; Guzhva, Vitaly S

    2011-05-01

    General aviation (GA) accounts for more than 82% of all air transport-related accidents and air transport-related fatalities in the U.S. In this study, we conduct a series of statistical analyses to investigate the significance of a pilot's gender, age and experience in influencing the risk for pilot errors and fatalities in GA accidents. There is no evidence from the Chi-square tests and logistic regression models that support the likelihood of an accident caused by pilot error to be related to pilot gender. However, evidence is found that male pilots, those older than 60 years of age, and with more experience, are more likely to be involved in a fatal accident.

  14. Organisational Factors of Occupational Accidents with Movement Disturbance (OAMD) and Prevention

    PubMed Central

    LECLERCQ, Sylvie

    2014-01-01

    Workplace design and upkeep, or human factors, are frequently advanced for explaining so-called Occupational Slip, Trip and Fall Accidents (OSTFAs). Despite scientific progress, these accidents, and more broadly Occupational Accidents with Movement Disturbance (OAMDs), are also commonly considered to be “simple”. This paper aims to stimulate changes in such perceptions by focusing on organisational factors that often combine with other accident factors to cause movement disturbance and injury in work situations. These factors frequently lead to arbitration between production and safety, which involves implementation of controls by workers. These controls can lead to greater worker exposure to OAMD risk. We propose a model that focuses on such controls to account specifically for the need to confront production and safety logics within a company and to enhance the potential for appropriate prevention action. These are then integrated into the set of controls highlighted by work organisation model developed by the NIOSH. PMID:25345425

  15. Iodine chemical forms in LWR severe accidents

    SciTech Connect

    Weber, C.F.; Beahm, E.C.; Kress, T.S.

    1991-01-01

    Calculated data from seven severe accident sequences in light water reactor plants were used to assess the chemical forms of iodine in containment. In most of the calculations for the seven sequences, iodine entering containment from the reactor coolant system was almost entirely in the form of CsI with very small contributions of I or HI. The largest fraction of iodine in forms other than CsI was a total of 3.2% as I plus HI. Within the containment, the CsI will deposit onto walls and other surfaces, as well as in water pools, largely in the form of iodide (I{sup {minus}}). The radiation-induced conversion of I{sup {minus}} in water pools into I{sub 2} is strongly dependent on pH. In systems where the pH was controlled above 7, little additional elemental iodine would be produced in the containment atmosphere. When the pH falls below 7, it may be assumed that it is not being controlled and large fractions of iodine as I{sub 2} within the containment atmosphere may be produced. 17 refs., 5 tabs.

  16. Iodine chemical forms in LWR severe accidents

    SciTech Connect

    Beahm, E.C.; Weber, C.F.; Kress, T.S.; Parker, G.W.

    1991-01-01

    Calculated data from seven severe accident sequences in light-water reactor plants were used to assess the chemical forms of iodine in containment. In most of the calculations for the seven sequences, iodine entering containment from the reactor coolant system was almost entirely in the form of CsI with very small contributions of I or HI. The largest fraction of iodine in forms other than CsI was a total of 3.2% as I plus HI. Within the containment, the CsI will deposit onto walls and other surfaces, as well as in water pools, largely in the form of iodide (I{sup {minus}}). The radiation induced conversion of I{sup {minus}} in water pools into I{sub 2} is strongly dependent on pH. In systems where the pH was controlled above 7, little additional elemental iodine would be produced in the containment atmosphere. When the pH falls below 7, it may be assumed that it is not being controlled, and large fractions of iodine as I{sub 2} within the containment atmosphere may be produced. 16 refs.

  17. Typical patterns in road-traffic accidents during driver training: an explorative Swedish national study.

    PubMed

    Berg, Hans-Yngve; Gregersen, Nils P; Laflamme, Lucie

    2004-07-01

    A new law came into force in Sweden on 1 September 1993, which makes instructor-assisted driving practice possible at the age of 16 years instead of the previous 17 years and 6 months. When the age limit was reduced, the possibility that this would lead to more road-traffic accidents (RTA) during driving practice was discussed. The aim of this study was to highlight typical road-traffic accident patterns and to discuss their potential for improved training and targeted prevention. A total of 11 variables (41 categories) descriptive of the 1081 RTA involving novice drivers and police registered during the period 1994-1999 were analysed simultaneously using in turn, two multivariate analysis techniques: the Factorial Analysis of Correspondence (FAC) and the Hierarchical Ascendant Classification (HAC). Four accident classes were identified and quantified, of which the first two were more typical of rural areas: (1). accidents in rural areas on straight stretches and related to speed limit 70 km/h (n = 306); (2). accidents in rural areas on straight stretches and high-speed related (n = 97); (3). accidents in built-up areas, low-speed related and of the type rear-end (n = 289); and (4). accidents in built-up areas, at road junctions and low-speed related (n = 380). Together, these classes point to a variety of opportunities to develop ways of working with targeted prevention. Instead of adopting a general attempt to counteract the relationship between individual variables and accidents, it is possible instead to focus on a whole context and its relationship with its typical accidents and any resulting injuries. This, in its turn, allows greater specificity in the build up of the Swedish licence and training regulations and its corresponding course curriculum. PMID:15094413

  18. A Serious Game for Traffic Accident Investigators

    ERIC Educational Resources Information Center

    Binsubaih, Ahmed; Maddock, Steve; Romano, Daniela

    2006-01-01

    In Dubai, traffic accidents kill one person every 37 hours and injure one person every 3 hours. Novice traffic accident investigators in the Dubai police force are expected to "learn by doing" in this intense environment. Currently, they use no alternative to the real world in order to practice. This paper argues for the use of an alternative…

  19. 48 CFR 36.513 - Accident prevention.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Accident prevention. 36.513 Section 36.513 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL... prevention. (a) The contracting officer shall insert the clause at 52.236-13, Accident Prevention,...

  20. Global estimates of fatal occupational accidents.

    PubMed

    Takala, J

    1999-09-01

    Data on occupational accidents are not available from all countries in the world. Furthermore, underreporting, limited coverage by reporting and compensation schemes, and non-harmonized accident recording and notification systems undermine efforts to obtain worldwide information on occupational accidents. This paper presents a method and new estimated global figures of fatal accidents at work by region. The fatal occupational accident rates reported to the International Labour Office are extended to the total employed workforce in countries and regions. For areas not covered by the reported information, rates from other countries that have similar or comparable conditions are applied. In 1994, an average estimated fatal occupational accident rate in the whole world was 14.0 per 100,000 workers, and the total estimated number of fatal occupational accidents was 335,000. The rates are different for individual countries and regions and for separate branches of economic activity. In conclusion, fatal occupational accident figures are higher than previously estimated. The new estimates can be gradually improved by obtaining and adding data from countries where information is not yet available. Sectoral estimates for at least key economic branches in individual countries would further increase the accuracy.