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  1. International Research Results and Accomplishments From the International Space Station

    NASA Technical Reports Server (NTRS)

    Ruttley, Tara M.; Robinson, Julie A.; Tate-Brown, Judy; Perkins, Nekisha; Cohen, Luchino; Marcil, Isabelle; Heppener, Marc; Hatton, Jason; Tasaki, Kazuyuki; Umemura, Sayaka; Karabadzhak, Georgy; Sorokin, Igor V.; Cotronei, Vittorio; Sabbagh, Jean

    2016-01-01

    In 2016, the International Space Station (ISS) partnership published the first-ever compilation of international ISS research publications resulting from research performed on the ISS through 2011. The International Space Station Research Accomplishments: An Analysis of Results From 2000-2011 is a collection of summaries of over 1,200 journal publications that describe ISS research in the areas of biology and biotechnology; Earth and space science; educational activities and outreach; human research; physical sciences; technology development and demonstration; and, results from ISS operations. This paper will summarize the ISS results publications obtained through 2011 on behalf of the ISS Program Science Forum that is made up of senior science representatives across the international partnership. NASA's ISS Program Science office maintains an online experiment database (www.nasa.gov/issscience) that tracks and communicates ISS research activities across the entire ISS partnership, and it is continuously updated. It captures ISS experiment summaries and results and includes citations to the journals, conference proceedings, and patents as they become available. The International Space Station Research Accomplishments: An Analysis of Results From 2000-2011 is a testament to the research that was underway even as the ISS laboratory was being built. It reflects the scientific knowledge gained from ISS research, and how it impact the fields of science in both space and traditional science disciplines on Earth. Now, during a time when utilization is at its busiest, and with extension of the ISS through at least 2024, the ISS partners work together to track the accomplishments and the new knowledge gained in a way that will impact humanity like no laboratory on Earth. The ISS Program Science Forum will continue to capture and report on these results in the form of journal publications, conference proceedings, and patents. We anticipate that successful ISS research will

  2. Apollo experience report: Electronic systems test program accomplishments and results

    NASA Technical Reports Server (NTRS)

    Ohnesorge, T. E.

    1972-01-01

    A chronological record is presented of the Electronic Systems Test Program from its conception in May 1963 to December 1969. The original concept of the program, which was primarily a spacecraft/Manned Space Flight Network communications system compatibility and performance evaluation, is described. The evolution of these concepts to include various levels of test detail, as well as systems level design verification testing, is discussed. Actual implementation of these concepts is presented, and the facility to support the program is described. Test results are given, and significant contributions to the lunar landing mission are underlined. Plans for modifying the facility and the concepts, based on Apollo experience, are proposed.

  3. International Research Results and Accomplishments From the International Space Station - A New Compilation

    NASA Technical Reports Server (NTRS)

    Ruttley, Tara; Robinson, Julie A.; Tate-Brown, Judy; Perkins, Nekisha; Cohen, Luchino; Marcil, Isabelle; Heppener, Marc; Hatton, Jason; Tasaki, Kazuyuki; Umemura, Sayaka; Karabadzhak, Georgy; Sorokin, Igor V.; Cotronei, Vittorio; Jean, Sabbagh

    2016-01-01

    In 2016, the International Space Station (ISS) partnership published the first-ever compilation of international ISS research publications resulting from research performed on the ISS through 2011 (Expeditions 0 through 30). International Space Station Research Accomplishments: An Analysis of Results. From 2000-2011 is a collection of over 1,200 journal publications that describe ISS research in the areas of biology and biotechnology; Earth and space science; educational activities and outreach; human research; physical sciences; technology development and demonstration; and, results from ISS operations. This paper will summarize the ISS results publications obtained through 2011 on behalf of the ISS Program Science Forum that is made up of senior science representatives across the international partnership. NASA's ISS Program Science office maintains an online experiment database (www.nasa.gov/iss- science) that tracks and communicates ISS research activities across the entire ISS partnership, and it is continuously updated by cooperation and linking with the results tracking activities of each partner. It captures ISS experiment summaries and results and includes citations to the journals, conference proceedings, and patents as they become available. This content is obtained through extensive and regular journal and patent database searches, and input provided by the ISS international partners ISS scientists themselves. The International Space Station Research Accomplishments: An Analysis of Results From 2000-2011 is a testament to the research that was underway even as the ISS laboratory was being built. It rejects the scientific knowledge gained from ISS research, and how it impact the fields of science in both space and traditional science disciplines on Earth. Now, during a time when utilization is at its busiest, and with extension of the ISS through at least 2024, the ISS partners work together to track the accomplishments and the new knowledge gained in a

  4. Accomplishments '70.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Stanford Center for Research and Development in Teaching.

    This annual report examines the accomplishments during 1970 of three programs. The first program was to improve the organizational and administrative environment for teaching. Its subsidiary projects were 1) the organizational context of teaching; 2) professional socialization of the teacher; 3) attitudes of teachers toward their occupation; 4)…

  5. International Space Station Science Research Accomplishments During the Assembly Years: An Analysis of Results from 2000-2008

    NASA Technical Reports Server (NTRS)

    Evans, Cynthia A.; Robinson, Julie A.; Tate-Brown, Judy; Thumm, Tracy; Crespo-Richey, Jessica; Baumann, David; Rhatigan, Jennifer

    2009-01-01

    This report summarizes research accomplishments on the International Space Station (ISS) through the first 15 Expeditions. When research programs for early Expeditions were established, five administrative organizations were executing research on ISS: bioastronautics research, fundamental space biology, physical science, space product development, and space flight. The Vision for Space Exploration led to changes in NASA's administrative structures, so we have grouped experiments topically by scientific themes human research for exploration, physical and biological sciences, technology development, observing the Earth, and educating and inspiring the next generation even when these do not correspond to the administrative structure at the time at which they were completed. The research organizations at the time at which the experiments flew are preserved in the appendix of this document. These investigations on the ISS have laid the groundwork for research planning for Expeditions to come. Humans performing scientific investigations on ISS serve as a model for the goals of future Exploration missions. The success of a wide variety of investigations is an important hallmark of early research on ISS. Of the investigations summarized here, some are completed with results released, some are completed with preliminary results, and some remain ongoing.

  6. Why different gas flux velocity parameterizations result in so similar flux results in the North Atlantic?

    NASA Astrophysics Data System (ADS)

    Piskozub, Jacek; Wróbel, Iwona

    2016-04-01

    The North Atlantic is a crucial region for both ocean circulation and the carbon cycle. Most of ocean deep waters are produced in the basin making it a large CO2 sink. The region, close to the major oceanographic centres has been well covered with cruises. This is why we have performed a study of net CO2 flux dependence upon the choice of gas transfer velocity k parameterization for this very region: the North Atlantic including European Arctic Seas. The study has been a part of a ESA funded OceanFlux GHG Evolution project and, at the same time, a PhD thesis (of I.W) funded by Centre of Polar Studies "POLAR-KNOW" (a project of the Polish Ministry of Science). Early results have been presented last year at EGU 2015 as a PICO presentation EGU2015-11206-1. We have used FluxEngine, a tool created within an earlier ESA funded project (OceanFlux Greenhouse Gases) to calculate the North Atlantic and global fluxes with different gas transfer velocity formulas. During the processing of the data, we have noticed that the North Atlantic results for different k formulas are more similar (in the sense of relative error) that global ones. This was true both for parameterizations using the same power of wind speed and when comparing wind squared and wind cubed parameterizations. This result was interesting because North Atlantic winds are stronger than the global average ones. Was the flux result similarity caused by the fact that the parameterizations were tuned to the North Atlantic area where many of the early cruises measuring CO2 fugacities were performed? A closer look at the parameterizations and their history showed that not all of them were based on North Atlantic data. Some of them were tuned to the South Ocean with even stronger winds while some were based on global budgets of 14C. However we have found two reasons, not reported before in the literature, for North Atlantic fluxes being more similar than global ones for different gas transfer velocity parametrizations

  7. Fewer Doses of HPV Vaccine Result in Immune Response Similar to Three-Dose Regimen

    MedlinePlus

    ... Releases NCI News Note Fewer doses of HPV vaccine result in immune response similar to three-dose ... that two doses of a human papillomavirus (HPV) vaccine, trademarked as Cervarix, resulted in similar serum antibody ...

  8. Wind Program Accomplishments

    SciTech Connect

    Wind Program

    2012-05-24

    This fact sheet describes some of the accomplishments of DOE's Wind Program through its investments in technology development and market barrier reduction, and how those accomplishments are supporting the advancement of renewable energy generated using the United States' abundant wind resources.

  9. Fewer doses of HPV vaccine result in immune response similar to three-dose regimen

    Cancer.gov

    NCI scientists report that two doses of a human papillomavirus (HPV) vaccine, trademarked as Cervarix, resulted in similar serum antibody levels against two of the most carcinogenic types of HPV (16 and 18), compared to a standard three dose regimen.

  10. A Uniqueness Result for Self-Similar Profiles to Smoluchowski's Coagulation Equation Revisited

    NASA Astrophysics Data System (ADS)

    Niethammer, B.; Throm, S.; Velázquez, J. J. L.

    2016-07-01

    In this note we indicate how to correct the proof of a uniqueness result in [6] for self-similar solutions to Smoluchowski's coagulation equation for kernels K=K(x,y) that are homogeneous of degree zero and close to constant in the sense that begin{aligned} -\\varepsilon le K(x,y)-2 le \\varepsilon Big ( Big (x/yBig )^{α } + Big (y/xBig )^{α }Big ) for α in [0,1/2). Under the additional assumption, in comparison to [6], that K has an analytic extension to mathbb {C}{setminus } (-infty ,0] and that the precise asymptotic behaviour of K at the origin is prescribed, we prove that self-similar solutions with given mass are unique if \\varepsilon is sufficiently small. The complete details of the proof are available in [4]. In addition, we give here the proof of a uniqueness result for a related but simpler problem that appears in the description of self-similar solutions for x → infty.

  11. The Spacelab Accomplishments Forum

    NASA Technical Reports Server (NTRS)

    Emond, J. (Editor); Bennett, N. (Compiler); McCauley, D. (Compiler); Murphy, K. (Compiler)

    2000-01-01

    This document is a record of the Spacelab Accomplishments Forum held in March 1999. Presentations made at the Forum covered the design, engineering, utilization, and science associated with Spacelab, as well as the international associations and impact of Spacelab and its use in the design and utilization of the International Space Station. Topics included Earth observations, space science, life science, commercial uses, microgravity science, and international participation.

  12. Similarity-based restoration of metrical information: different listening experiences result in different perceptual inferences.

    PubMed

    Creel, Sarah C

    2012-09-01

    How do perceivers apply knowledge to instances they have never experienced before? On one hand, listeners might use idealized representations that do not contain specific details. On the other, they might recognize and process information based on more detailed memory representations. The current study examined the latter possibility with respect to musical meter perception, previously thought to be computed based on highly-idealized (isochronous) internal representations. In six experiments, listeners heard sets of metrically-ambiguous melodies. Each melody was played in a simultaneous musical context with unambiguous metrical cues (3/4 or 6/8). Cross-melody similarity was manipulated by pairing certain cues-timbre (musical instrument) and motif content (2-6-note patterns)-with each meter, or distributing cues across meters. After multiple exposures, listeners heard each melody without context, and judged metrical continuations (all Experiments) or familiarity (Experiments 5-6). Responses were assessed for "metrical restoration"-the tendency to make metrical judgments that fit the melody's previously-heard metrical context. Cross-melody similarity affected the presence and degree of metrical restoration, and timbre affected familiarity. Results suggest that metrical processing may be calculated based on fairly detailed representations rather than idealized isochronous pulses, and is dissociated somewhat from familiarity judgments. Implications for theories of meter perception are discussed. PMID:22659582

  13. Life sciences accomplishments

    NASA Technical Reports Server (NTRS)

    1985-01-01

    From its inception, the main charter of Life Sciences has been to define biomedical requirements for the design and development of spacecraft systems and to participate in NASA's scientific exploration of the universe. The role of the Life Sciences Division is to: (1) assure the health, well being and productivity of all individuals who fly in space; (2) study the origin, evolution, and distribution of life in the universe; and (3) to utilize the space environment as a tool for research in biology and medicine. The activities, programs, and accomplishments to date in the efforts to achieve these goals are detailed and the future challenges that face the division as it moves forward from the shuttle era to a permanent manned presence in space space station's are examined.

  14. Implantation of peritoneal catheters by laparotomy: nephrologists obtained similar results to general surgeons

    PubMed Central

    Restrepo, Cesar A; Buitrago, Carlos Alberto; Holguin, Cielo

    2014-01-01

    Purpose To analyze the complications and costs of minilaparotomies performed by a nephrologist (group A) compared with conventional laparotomies performed by a surgeon (group B) for peritoneal catheter implantation. Setting Two university hospitals (Santa Sofia and Caldas) in Manizales, Caldas, Colombia. Methods The study included stage 5 chronic kidney disease patients, with indication of renal replacement therapy, who were candidates for peritoneal dialysis and gave informed consent for a peritoneal catheter implant. Minilaparotomies were performed by a nephrologist in a minor surgery room under local anesthesia. Conventional laparotomies were performed by a surgeon in an operating room under general anesthesia. Results Two nephrologists inserted 157 peritoneal catheters, and seven general surgeons inserted 185 peritoneal catheters. The groups had similar characteristics: the mean age was 55 years, 49.5% were men, and the primary diagnoses were diabetic nephropathy, hypertensive nephropathy, and unknown etiology. The implant was successful for 98.09% of group A and 99.46% of group B. There was no procedure-related mortality. The most frequent complications in the first 30 days postsurgery in group A versus group B, respectively, were: peritonitis (6.37% versus 3.78%), exit-site infection (3.82% versus 2.16%), tunnel infection (0% versus 0.54%), catheter entrapment by omentum (1.27% versus 3.24%), peritoneal effluent spillover (1.91% versus 2.16%), draining failure (4.46% versus 6.49%), hematoma (0% versus 1.08%), catheter migration with kinking (3.18% versus 2.70%), hemoperitoneum (1.27% versus 0%), and hollow viscera accidental puncture (1.91% versus 0.54%). There were no statistically significant differences in the number of complications between groups. In 2013, the cost of a surgeon-implanted peritoneal dialysis catheter in Colombia was US $366 (666,000 COP), whereas the cost of a nephrologist-implanted catheter was US $198 (356,725 COP). Conclusion

  15. Life Sciences Accomplishments 1994

    NASA Technical Reports Server (NTRS)

    Burnell, Mary Lou (Editor)

    1993-01-01

    proposals for ground-based and flight research for all programs. Areas of particular interest to NASA were defined Proposals due April 29, 1994, will be peer reviewed - externally for scientific merit. This annual NRA process is now the mechanism for recruiting both extramural and intramural investigations. As an overview of LBSAD activities in 1993, this accomplishments document covers each of the major organizational components of the Division and the accomplishments of each. The second section is a review of the Space Life Sciences Research programs Space Biology, Space Physiology and Countermeasures, Radiation Health, Environmental Health, Space Human Factors, Advanced Life Support, and Global Monitoring and Disease Prediction, The third section, Research in Space Flight, describes the substantial contributions of the Spacelab Life Sciences 2 (SLS-2) mission to life sciences research and the significant contributions of the other missions flown in 1993, along with plans for future missions. The Division has greatly expanded and given high priority to its Education and Outreach Programs, which are presented in the fourth section. The fifth and final section, Partners for Space, shows the Divisions Cooperative efforts with other national and international agencies to achieve common goals, along with the accomplishments of joint research and analysis programs.

  16. EFRC CMSNF Major Accomplishments

    SciTech Connect

    D. Hurley; Todd R. Allen

    2014-09-01

    The mission of the Center for Material Science of Nuclear Fuels (CMSNF) has been to develop a first-principles-based understanding of thermal transport in the most widely used nuclear fuel, UO2, in the presence of defect microstructure associated with radiation environments. The overarching goal within this mission was to develop an experimentally validated multiscale modeling capability directed toward a predictive understanding of the impact of radiation and fission-product induced defects and microstructure on thermal transport in nuclear fuel. Implementation of the mission was accomplished by integrating the physics of thermal transport in crystalline solids with microstructure science under irradiation through multi institutional experimental and computational materials theory teams from Idaho National Laboratory, Oak Ridge National Laboratory, Purdue University, the University of Florida, the University of Wisconsin, and the Colorado School of Mines. The Center’s research focused on five major areas: (i) The fundamental aspects of anharmonicity in UO2 crystals and its impact on thermal transport; (ii) The effects of radiation microstructure on thermal transport in UO2; (iii) The mechanisms of defect clustering in UO2 under irradiation; (iv) The effect of temperature and oxygen environment on the stoichiometry of UO2; and (v) The mechanisms of growth of dislocation loops and voids under irradiation. The Center has made important progress in each of these areas, as summarized below.

  17. Transmutation Fuels Campaign FY-09 Accomplishments Report

    SciTech Connect

    Lori Braase

    2009-09-01

    This report summarizes the fiscal year 2009 (FY-08) accomplishments for the Transmutation Fuels Campaign (TFC). The emphasis is on the accomplishments and relevance of the work. Detailed description of the methods used to achieve the highlighted results and the associated support tasks are not included in this report.

  18. Results of analysis of galaxy clusters from the standpoint of similarity and dimensional theory

    NASA Astrophysics Data System (ADS)

    Golitsyn, G. S.

    2016-01-01

    Studies of galaxy clusters enable the evolution of the Universe at various stages of its life to be traced. The luminosities, sizes, temperatures, and masses of clusters are measured during their observations. Clusters are bound by gravitation with the universal constant G into a single whole. All these quantities are defined by three units of measurement: mass, length, and time. Therefore, there are two dimensionless parameters in the system usually called similarity parameters. One of them is the virial ratio of the potential and kinetic energies.

  19. Distinct stress conditions result in aggregation of proteins with similar properties

    PubMed Central

    Weids, Alan J.; Ibstedt, Sebastian; Tamás, Markus J.; Grant, Chris M.

    2016-01-01

    Protein aggregation is the abnormal association of proteins into larger aggregate structures which tend to be insoluble. This occurs during normal physiological conditions and in response to age or stress-induced protein misfolding and denaturation. In this present study we have defined the range of proteins that aggregate in yeast cells during normal growth and after exposure to stress conditions including an oxidative stress (hydrogen peroxide), a heavy metal stress (arsenite) and an amino acid analogue (azetidine-2-carboxylic acid). Our data indicate that these three stress conditions, which work by distinct mechanisms, promote the aggregation of similar types of proteins probably by lowering the threshold of protein aggregation. The proteins that aggregate during physiological conditions and stress share several features; however, stress conditions shift the criteria for protein aggregation propensity. This suggests that the proteins in aggregates are intrinsically aggregation-prone, rather than being proteins which are affected in a stress-specific manner. We additionally identified significant overlaps between stress aggregating yeast proteins and proteins that aggregate during ageing in yeast and C. elegans. We suggest that similar mechanisms may apply in disease- and non-disease settings and that the factors and components that control protein aggregation may be evolutionary conserved. PMID:27086931

  20. NASA space biology accomplishments, 1982

    NASA Technical Reports Server (NTRS)

    Halstead, T. W.; Pleasant, L. G.

    1983-01-01

    Summaries of NASA's Space Biology Program projects are provided. The goals, objectives, accomplishments, and future plans of each project are described in this publication as individual technical summaries.

  1. Are lorazepam-induced deficits in attention similar to those resulting from aging?

    PubMed

    Fluck, E; Fernandes, C; File, S E

    2001-04-01

    The purpose of this experiment was to compare, in three tasks of attention, the impairment caused by lorazepam (1 and 2.5 mg) administered to young volunteers with the impairment that results from aging. Performance on digit cancellation (DC), digit-symbol substitution (DSS), and Paced Auditory Serial Addition Task (PASAT) was significantly impaired by lorazepam (2.5 mg) and was significantly worse in the middle-aged group (mean +/- SEM, aged 58.9+/-0.8 years) compared with the younger, IQ-matched group (20.7+/-0.2 years). However, there were interesting differences in the extent of impairments among the three tests. In the DC test, lorazepam (2.5 mg) produced a significantly greater impairment than was seen in either the middle-aged men or middle-aged women. However, in the DSS test, the middle-aged women were significantly more impaired than either the middle-aged men or the young volunteers tested after lorazepam (2.5 mg). In the PASAT, both the lorazepam (2.5 mg) group and the middle-aged women were more impaired than the middle-aged men. These results raise the important possibility of gender differences in age-related decline of attentional processes.

  2. Subduction in fancy: stripping young slabs as a result of similar crust-mantle rheologies

    NASA Astrophysics Data System (ADS)

    Agard, Philippe; Yamato, Philippe; Soret, Mathieu; Prigent, Cécile; Guillot, Stéphane; Plunder, Alexis; Dubacq, Benoît; Monié, Patrick; Chauvet, Alain

    2016-04-01

    Understanding subduction rheology in both space and time has been a challenge since the advent of plate tectonics. We herein focus on "subduction infancy", which corresponds to the first ~0-2 My immediately following subduction nucleation, when a newly born slab penetrates into the overriding plate mantle and heats up. The only remnants of this critical, yet elusive, geodynamic step are thin metamorphic soles, commonly found beneath pristine, 100-1000 km long portions of oceanic lithosphere emplaced on top of continents (i.e., ophiolites). In this study, we show how, during subduction infancy, transient mechanical properties of both the mantle and crust across the subduction plate interface (during ~100s ky) control and hinder the penetration of tectonic plates into the mantle, and how this results in strong peaks of resistance and even slicing of their surface - leaving behind thin, chopped-off metamorphic slivers (i.e., metamorphic soles). These findings constrain the mechanical behaviour of the subduction plate interface (with implications for coupling processes and earthquake generation) as well as the properties of the crust and mantle. They also highlight the role of fluids in enabling subduction to overcome this early resistance.

  3. Hipparcos: mission accomplished

    NASA Astrophysics Data System (ADS)

    1993-08-01

    During the last few months of its life, as the high radiation environment to which the satellite was exposed took its toll on the on-board system, Hipparcos was operated with only two of the three gyroscopes normally required for such a satellite, following an ambitious redesign of the on-board and on-ground systems. Plans were in hand to operate the satellite without gyroscopes at all, and the first such "gyro- less" data had been acquired, when communication failure with the on-board computers on 24 June 1993 put an end to the relentless flow of 24000 bits of data that have been sent down from the satellite each second, since launch. Further attempts to continue operations proved unsuccessful, and after a short series of sub-systems tests, operations were terminated four years and a week after launch. An enormous wealth of scientific data was gathered by Hipparcos. Even though data analysis by the scientific teams involved in the programme is not yet completed, it is clear that the mission has been an overwhelming success. "The ESA advisory bodies took a calculated risk in selecting this complex but fundamental programme" said Dr. Roger Bonnet, ESA's Director of Science, "and we are delighted to have been able to bring it to a highly successful conclusion, and to have contributed unique information that will take a prominent place in the history and development of astrophysics". Extremely accurate positions of more than one hundred thousand stars, precise distance measurements (in most cases for the first time), and accurate determinations of the stars' velocity through space have been derived. The resulting HIPPARCOS Star Catalogue, expected to be completed in 1996, will be of unprecedented accuracy, achieving results some 10-100 times more accurate than those routinely determined from ground-based astronomical observatories. A further star catalogue, the Thyco Star Catalogue of more than a million stars, is being compiled from additional data accumulated by the

  4. Hipparcos: mission accomplished

    NASA Astrophysics Data System (ADS)

    1993-08-01

    During the last few months of its life, as the high radiation environment to which the satellite was exposed took its toll on the on-board system, Hipparcos was operated with only two of the three gyroscopes normally required for such a satellite, following an ambitious redesign of the on-board and on-ground systems. Plans were in hand to operate the satellite without gyroscopes at all, and the first such "gyro- less" data had been acquired, when communication failure with the on-board computers on 24 June 1993 put an end to the relentless flow of 24000 bits of data that have been sent down from the satellite each second, since launch. Further attempts to continue operations proved unsuccessful, and after a short series of sub-systems tests, operations were terminated four years and a week after launch. An enormous wealth of scientific data was gathered by Hipparcos. Even though data analysis by the scientific teams involved in the programme is not yet completed, it is clear that the mission has been an overwhelming success. "The ESA advisory bodies took a calculated risk in selecting this complex but fundamental programme" said Dr. Roger Bonnet, ESA's Director of Science, "and we are delighted to have been able to bring it to a highly successful conclusion, and to have contributed unique information that will take a prominent place in the history and development of astrophysics". Extremely accurate positions of more than one hundred thousand stars, precise distance measurements (in most cases for the first time), and accurate determinations of the stars' velocity through space have been derived. The resulting HIPPARCOS Star Catalogue, expected to be completed in 1996, will be of unprecedented accuracy, achieving results some 10-100 times more accurate than those routinely determined from ground-based astronomical observatories. A further star catalogue, the Thyco Star Catalogue of more than a million stars, is being compiled from additional data accumulated by the

  5. ADVANCED FUELS CAMPAIGN 2013 ACCOMPLISHMENTS

    SciTech Connect

    Not Listed

    2013-10-01

    The mission of the Advanced Fuels Campaign (AFC) is to perform Research, Development, and Demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This includes development of a state-of-the art Research and Development (R&D) infrastructure to support the use of “goal-oriented science-based approach.” In support of the Fuel Cycle Research and Development (FCRD) program, AFC is responsible for developing advanced fuels technologies to support the various fuel cycle options defined in the Department of Energy (DOE) Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. Accomplishments made during fiscal year (FY) 2013 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the technical contact is provided for each section.

  6. Joint Winter Runway Friction Program Accomplishments

    NASA Technical Reports Server (NTRS)

    Yager, Thomas J.; Wambold, James C.; Henry, John J.; Andresen, Arild; Bastian, Matthew

    2002-01-01

    The major program objectives are: (1) harmonize ground vehicle friction measurements to report consistent friction value or index for similar contaminated runway conditions, for example, compacted snow, and (2) establish reliable correlation between ground vehicle friction measurements and aircraft braking performance. Accomplishing these objectives would give airport operators better procedures for evaluating runway friction and maintaining acceptable operating conditions, providing pilots information to base go/no go decisions, and would contribute to reducing traction-related aircraft accidents.

  7. Advanced Fuels Campaign 2012 Accomplishments

    SciTech Connect

    Not Listed

    2012-11-01

    The Advanced Fuels Campaign (AFC) under the Fuel Cycle Research and Development (FCRD) program is responsible for developing fuels technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The fiscal year 2012 (FY 2012) accomplishments are highlighted below. Kemal Pasamehmetoglu is the National Technical Director for AFC.

  8. Infant Mortality: 1989 Research Accomplishments.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

    Collected in this document are reports of the National Institutes of Health's 1989 accomplishments in research on the problem of infant mortality. Reports are provided by the: (1) National Institute of Child Health and Human Development; (2) National Cancer Institute; (3) National Heart, Lung, and Blood Institute; (4) National Institute of…

  9. The Joint Accomplishment of Identity

    ERIC Educational Resources Information Center

    Hand, Victoria; Gresalfi, Melissa

    2015-01-01

    Identity has become a central concept in the analysis of learning from social perspectives. In this article, we draw on a situative perspective to conceptualize identity as a "joint accomplishment" between individuals and their interactions with norms, practices, cultural tools, relationships, and institutional and cultural contexts.…

  10. Space Biophysics: Accomplishments, Trends, Challenges

    NASA Technical Reports Server (NTRS)

    Smith, Jeffrey D.

    2015-01-01

    Physics and biology are inextricably linked. All the chemical and biological processes of life are dutifully bound to follow the rules and laws of physics. In space, these physical laws seem to turn on their head and biological systems, from microbes to humans, adapt and evolve in myriad ways to cope with the changed physical influences of the space environment. Gravity is the most prominent change in space that influences biology. In microgravity, the physical processes of sedimentation, density-driven convective flow, influence of surface tension and fluid pressure profoundly influence biology at the molecular and cellular level as well as at the whole-body level. Gravity sensing mechanisms are altered, structural and functional components of biology (such as bone and muscle) are reduced and changes in the way fluids and gasses behave also drive the way microbial systems and biofilms grow as well as the way plants and animals adapt. The radiation environment also effects life in space. Solar particle events and high energy cosmic radiation can cause serious damage to DNA and other biomolecules. The results can cause mutation, cellular damage or death, leading to health consequences of acute radiation damage or long-term health consequences such as increased cancer risk. Space Biophysics is the study and utilization of physical changes in space that cause changes in biological systems. The unique physical environment in space has been used successfully to grow high-quality protein crystals and 3D tissue cultures that could not be grown in the presence of unidirectional gravitational acceleration here on Earth. All biological processes that change in space have their root in a biophysical alteration due to microgravity and/or the radiation environment of space. In order to fully-understand the risks to human health in space and to fully-understand how humans, plants, animals and microbes can safely and effectively travel and eventually live for long periods beyond

  11. A blended design in acute care training: similar learning results, less training costs compared with a traditional format.

    PubMed

    Dankbaar, Mary E W; Storm, Diana J; Teeuwen, Irene C; Schuit, Stephanie C E

    2014-09-01

    Introduction There is a demand for more attractive and efficient training programmes in postgraduate health care training. This retrospective study aims to show the effectiveness of a blended versus traditional face-to-face training design. For nurses in postgraduate Acute and Intensive Care training, the effectiveness of a blended course design was compared with a traditional design. Methods In a first pilot study 57 students took a traditional course (2-h lecture and 2-h workshop) and 46 students took a blended course (2-h lecture and 2-h online self-study material). Test results were compared for both groups. After positive results in the pilot study, the design was replicated for the complete programme in Acute and Intensive Care. Now 16 students followed the traditional programme (11 days face-to-face education) and 31 students did the blended programme (7 days face-to-face and 40 h online self-study). An evaluation was done after the pilot and course costs were calculated. Results Results show that the traditional and blended groups were similar regarding the main characteristics and did not differ in learning results for both the pilot and the complete programme. Student evaluations of both designs were positive; however, the blended group were more confident that they had achieved the learning objectives. Training costs were reduced substantially. Conclusion The blended training design offers an effective and attractive training solution, leading to a significant reduction in costs.

  12. Low-Energy Nuclear Reactions Resulting as Picometer Interactions with Similarity to K-Shell Electron Capture

    NASA Astrophysics Data System (ADS)

    Hora, H.; Miley, G. H.; Li, X. Z.; Kelly, J. C.; Osman, F.

    2006-02-01

    Since the appeal by Brian Josephson at the meeting of the Nobel Laureates July 2004, it seems to be indicated to summarize the following serious, reproducible and confirmed observations on reactions of protons or deuterons incorporated in host metals such as palladium. Some reflections to Rutherford's discovery of nuclear physics, the Cockroft-Oliphant discovery of anomalous low-energy fusion reactions and the chemist Hahn's discovery of fission had to be included. Using gaseous atmosphere or discharges between palladium targets, rather significant results were seen e.g. from the "life after death" heat production of such high values per host atom that only nuclear reactions can be involved. This supports the earlier evaluation of neutron generation in fully reversible experiments with gas discharges hinting that a reasonable screening effect - preferably in the swimming electron layer - may lead to reactions at nuclear distances d of picometers with reaction probability times U of about megaseconds similar to the K-shell capture radioactivity. Further electrolytic experiments led to low-energy nuclear reactions (LENR) where the involvement of pollution could be excluded from the appearance of very seldom rare earth elements. A basically new theory for DD cross-sections is used to confirm the picometer-megasecond reactions of cold fusion. Other theoretical aspects are given from measured heavy element distributions similar to the standard abundance distribution, SAD, in the Universe with consequences on endothermic heavy nuclei generation, magic numbers and to quark-gluon plasmas.

  13. Advanced Fuels Campaign FY 2011 Accomplishments Report

    SciTech Connect

    Not Listed

    2011-11-01

    One of the major research and development (R&D) areas under the Fuel Cycle Research and Development (FCRD) program is advanced fuels development. The Advanced Fuels Campaign (AFC) has the responsibility to develop advanced fuel technologies for the Department of Energy (DOE) using a science-based approach focusing on developing a microstructural understanding of nuclear fuels and materials. Accomplishments made during fiscal year (FY 20) 2011 are highlighted in this report, which focuses on completed work and results. The process details leading up to the results are not included; however, the technical contact is provided for each section. The order of the accomplishments in this report is consistent with the AFC work breakdown structure (WBS).

  14. Activities and Accomplishments of ICAM

    NASA Technical Reports Server (NTRS)

    Tiwari, S. N.

    1997-01-01

    A brief historical background on establishing the Institute for Computational and Applied Mechanics (ICAM) is presented and basic goals and objectives are discussed. It is emphasized that the goal of the ICAM has been to develop and maintain a self-sustaining center of excellence in computational methods at Old Dominion University (ODU). Information is provided on funding sources and budget disposition, recent activities and accomplishments, list of graduate students supported on the program, and number of students who received graduate degrees (M.S. as well as Ph.D.). Information is also provided on research coordination with various scientists and engineers, and on different reports specifically written for ICAM. ICAM has been supported, in part, by NASA Langley Research Center through Grant NAG-1-363. This report constitutes the final report for ICAM for the period ending December 1996. The grant has been monitored by the University Affairs Officers at NASA Langley.

  15. FY005 Accomplishments for Colony Project

    SciTech Connect

    Jones, T; Kale, L; Moreira, J; Mendes, C; Chakravorty, S; Inglett, T; Tauferner, A

    2005-07-05

    The Colony Project is developing operating system and runtime system technology to enable efficient general purpose environments on tens of thousands of processors. To accomplish this, we are investigating memory management techniques, fault management strategies, and parallel resource management schemes. Recent results show promising findings for scalable strategies based on processor virtualization, in-memory checkpointing, and parallel aware modifications to full featured operating systems.

  16. NASA total quality management 1989 accomplishments report

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Described here are the accomplishments of NASA as a result of the use of Total Quality Management (TQM). The principles in practice which led to these process refinements are important cultural elements to any organization's productivity and quality efforts. The categories of TQM discussed here are top management leadership and support, strategic planning, focus on the customer, employee training and recognition, employee empowerment and teamwork, measurement and analysis, and quality assurance.

  17. Two Measurement Methods of Leaf Dry Matter Content Produce Similar Results in a Broad Range of Species

    PubMed Central

    Vaieretti, María Victoria; Díaz, Sandra; Vile, Denis; Garnier, Eric

    2007-01-01

    Background and Aims Leaf dry matter content (LDMC) is widely used as an indicator of plant resource use in plant functional trait databases. Two main methods have been proposed to measure LDMC, which basically differ in the rehydration procedure to which leaves are subjected after harvesting. These are the ‘complete rehydration’ protocol of Garnier et al. (2001, Functional Ecology 15: 688–695) and the ‘partial rehydration’ protocol of Vendramini et al. (2002, New Phytologist 154: 147–157). Methods To test differences in LDMC due to the use of different methods, LDMC was measured on 51 native and cultivated species representing a wide range of plant families and growth forms from central-western Argentina, following the complete rehydration and partial rehydration protocols. Key Results and Conclusions The LDMC values obtained by both methods were strongly and positively correlated, clearly showing that LDMC is highly conserved between the two procedures. These trends were not altered by the exclusion of plants with non-laminar leaves. Although the complete rehydration method is the safest to measure LDMC, the partial rehydration procedure produces similar results and is faster. It therefore appears as an acceptable option for those situations in which the complete rehydration method cannot be applied. Two notes of caution are given for cases in which different datasets are compared or combined: (1) the discrepancy between the two rehydration protocols is greatest in the case of high-LDMC (succulent or tender) leaves; (2) the results suggest that, when comparing many studies across unrelated datasets, differences in the measurement protocol may be less important than differences among seasons, years and the quality of local habitats. PMID:17353207

  18. The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques.

    PubMed

    Turner, C H; Rho, J; Takano, Y; Tsui, T Y; Pharr, G M

    1999-04-01

    Acoustic microscopy (30-60 microm resolution) and nanoindentation (1-5 microm resolution) are techniques that can be used to evaluate the elastic properties of human bone at a microstructural level. The goals of the current study were (1) to measure and compare the Young's moduli of trabecular and cortical bone tissues from a common human donor, and (2) to compare the Young's moduli of bone tissue measured using acoustic microscopy to those measured using nanoindentation. The Young's modulus of cortical bone in the longitudinal direction was about 40% greater than (p<0.01) the Young's modulus in the transverse direction. The Young's modulus of trabecular bone tissue was slightly higher than the transverse Young's modulus of cortical bone, but substantially lower than the longitudinal Young's modulus of cortical bone. These findings were consistent for both measurement methods and suggest that elasticity of trabecular tissue is within the range of that of cortical bone tissue. The calculation of Young's modulus using nanoindentation assumes that the material is elastically isotropic. The current results, i.e., the average anisotropy ratio (E(L)/E(T)) for cortical bone determined by nanoindentation was similar to that determined by the acoustic microscope, suggest that this assumption does not limit nanoindentation as a technique for measurement of Young's modulus in anisotropic bone.

  19. 454 Pyrosequencing and Sanger sequencing of tropical mycorrhizal fungi provide similar results but reveal substantial methodological biases.

    PubMed

    Tedersoo, Leho; Nilsson, R Henrik; Abarenkov, Kessy; Jairus, Teele; Sadam, Ave; Saar, Irja; Bahram, Mohammad; Bechem, Eneke; Chuyong, George; Kõljalg, Urmas

    2010-10-01

    • Compared with Sanger sequencing-based methods, pyrosequencing provides orders of magnitude more data on the diversity of organisms in their natural habitat, but its technological biases and relative accuracy remain poorly understood. • This study compares the performance of pyrosequencing and traditional sequencing for species' recovery of ectomycorrhizal fungi on root tips in a Cameroonian rain forest and addresses biases related to multi-template PCR and pyrosequencing analyses. • Pyrosequencing and the traditional method yielded qualitatively similar results, but there were slight, but significant, differences that affected the taxonomic view of the fungal community. We found that most pyrosequencing singletons were artifactual and contained a strongly elevated proportion of insertions compared with natural intra- and interspecific variation. The alternative primers, DNA extraction methods and PCR replicates strongly influenced the richness and community composition as recovered by pyrosequencing. • Pyrosequencing offers a powerful alternative for the identification of ectomycorrhizal fungi in pooled root samples, but requires careful selection of molecular tools. A well-populated backbone database facilitates the detection of biological and technical artifacts. The pyrosequencing pipeline is available at http://unite.ut.ee/454pipeline.tgz.

  20. Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef Cattle

    PubMed Central

    Brito Lopes, Fernando; da Silva, Marcelo Corrêa; Magnabosco, Cláudio Ulhôa; Goncalves Narciso, Marcelo; Sainz, Roberto Daniel

    2016-01-01

    This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs). Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age) and carcass traits (longissimus muscle area (LMA), back-fat thickness (BF), and rump fat thickness (RF)), registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance) EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3) (P < 0.001). Estimates of genetic correlation among growth and carcass traits and the estimates of heritability were moderate to high, suggesting that a correlated response approach is suitable for practical decision making. Estimates of correlation between selection indices and the multivariate index (LD1) were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs). Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection. PMID:26789008

  1. Basic energy sciences: Summary of accomplishments

    NASA Astrophysics Data System (ADS)

    1990-05-01

    For more than four decades, the Department of Energy, including its predecessor agencies, has supported a program of basic research in nuclear- and energy related sciences, known as Basic Energy Sciences. The purpose of the program is to explore fundamental phenomena, create scientific knowledge, and provide unique user facilities necessary for conducting basic research. Its technical interests span the range of scientific disciplines: physical and biological sciences, geological sciences, engineering, mathematics, and computer sciences. Its products and facilities are essential to technology development in many of the more applied areas of the Department's energy, science, and national defense missions. The accomplishments of Basic Energy Sciences research are numerous and significant. Not only have they contributed to Departmental missions, but have aided significantly the development of technologies which now serve modern society daily in business, industry, science, and medicine. In a series of stories, this report highlights 22 accomplishments, selected because of their particularly noteworthy contributions to modern society. A full accounting of all the accomplishments would be voluminous. Detailed documentation of the research results can be found in many thousands of articles published in peer-reviewed technical literature.

  2. Basic Energy Sciences: Summary of Accomplishments

    DOE R&D Accomplishments Database

    1990-05-01

    For more than four decades, the Department of Energy, including its predecessor agencies, has supported a program of basic research in nuclear- and energy-related sciences, known as Basic Energy Sciences. The purpose of the program is to explore fundamental phenomena, create scientific knowledge, and provide unique user'' facilities necessary for conducting basic research. Its technical interests span the range of scientific disciplines: physical and biological sciences, geological sciences, engineering, mathematics, and computer sciences. Its products and facilities are essential to technology development in many of the more applied areas of the Department's energy, science, and national defense missions. The accomplishments of Basic Energy Sciences research are numerous and significant. Not only have they contributed to Departmental missions, but have aided significantly the development of technologies which now serve modern society daily in business, industry, science, and medicine. In a series of stories, this report highlights 22 accomplishments, selected because of their particularly noteworthy contributions to modern society. A full accounting of all the accomplishments would be voluminous. Detailed documentation of the research results can be found in many thousands of articles published in peer-reviewed technical literature.

  3. Technical Report --Final Work Accomplishment

    SciTech Connect

    Kim, Eun Heui

    2007-11-19

    The main goal of this project was to understand the solution structure of nonlinear boundary value problems arising in self-similar solutions of nonlinear systems of multidimensional conservation laws. This project further extended to study on biocomplex systems including Morphogen gradients systems (reaction-diffusion systems) and tumor growth and its treatment model problems (free boundary, conservation of mass and reaction-diffusion systems). The list of publications and the summary of those publications are listed.

  4. Gender-Role Orientation, Creative Accomplishments and Cognitive Styles.

    ERIC Educational Resources Information Center

    Hittner, James B.; Daniels, Jennifer R.

    2002-01-01

    This study examined the association of gender-role orientation to creative accomplishments and cognitive styles in 127 college students. Results indicated that the gender role orientation of instrumentality was positively associated with creative accomplishments in the business venture domain and that androgynous, versus non-androgynous,…

  5. Advanced Fuels Campaign FY 2010 Accomplishments Report

    SciTech Connect

    Lori Braase

    2010-12-01

    The Fuel Cycle Research and Development (FCRD) Advanced Fuels Campaign (AFC) Accomplishment Report documents the high-level research and development results achieved in fiscal year 2010. The AFC program has been given responsibility to develop advanced fuel technologies for the Department of Energy (DOE) using a science-based approach focusing on developing a microstructural understanding of nuclear fuels and materials. The science-based approach combines theory, experiments, and multi-scale modeling and simulation aimed at a fundamental understanding of the fuel fabrication processes and fuel and clad performance under irradiation. The scope of the AFC includes evaluation and development of multiple fuel forms to support the three fuel cycle options described in the Sustainable Fuel Cycle Implementation Plan4: Once-Through Cycle, Modified-Open Cycle, and Continuous Recycle. The word “fuel” is used generically to include fuels, targets, and their associated cladding materials. This document includes a brief overview of the management and integration activities; but is primarily focused on the technical accomplishments for FY-10. Each technical section provides a high level overview of the activity, results, technical points of contact, and applicable references.

  6. Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men.

    PubMed

    Mitchell, Cameron J; McGregor, Robin A; D'Souza, Randall F; Thorstensen, Eric B; Markworth, James F; Fanning, Aaron C; Poppitt, Sally D; Cameron-Smith, David

    2015-10-21

    The differential ability of various milk protein fractions to stimulate muscle protein synthesis (MPS) has been previously described, with whey protein generally considered to be superior to other fractions. However, the relative ability of a whole milk protein to stimulate MPS has not been compared to whey. Sixteen healthy middle-aged males ingested either 20 g of milk protein (n = 8) or whey protein (n = 8) while undergoing a primed constant infusion of ring (13)C₆ phenylalanine. Muscle biopsies were obtained 120 min prior to consumption of the protein and 90 and 210 min afterwards. Resting myofibrillar fractional synthetic rates (FSR) were 0.019% ± 0.009% and 0.021% ± 0.018% h(-1) in the milk and whey groups respectively. For the first 90 min after protein ingestion the FSR increased (p < 0.001) to 0.057% ± 0.018% and 0.052% ± 0.024% h(-1) in the milk and whey groups respectively with no difference between groups (p = 0.810). FSR returned to baseline in both groups between 90 and 210 min after protein ingestion. Despite evidence of increased rate of digestion and leucine availability following the ingestion of whey protein, there was similar activation of MPS in middle-aged men with either 20 g of milk protein or whey protein.

  7. Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men

    PubMed Central

    Mitchell, Cameron J.; McGregor, Robin A.; D’Souza, Randall F.; Thorstensen, Eric B.; Markworth, James F.; Fanning, Aaron C.; Poppitt, Sally D.; Cameron-Smith, David

    2015-01-01

    The differential ability of various milk protein fractions to stimulate muscle protein synthesis (MPS) has been previously described, with whey protein generally considered to be superior to other fractions. However, the relative ability of a whole milk protein to stimulate MPS has not been compared to whey. Sixteen healthy middle-aged males ingested either 20 g of milk protein (n = 8) or whey protein (n = 8) while undergoing a primed constant infusion of ring 13C6 phenylalanine. Muscle biopsies were obtained 120 min prior to consumption of the protein and 90 and 210 min afterwards. Resting myofibrillar fractional synthetic rates (FSR) were 0.019% ± 0.009% and 0.021% ± 0.018% h−1 in the milk and whey groups respectively. For the first 90 min after protein ingestion the FSR increased (p < 0.001) to 0.057% ± 0.018% and 0.052% ± 0.024% h−1 in the milk and whey groups respectively with no difference between groups (p = 0.810). FSR returned to baseline in both groups between 90 and 210 min after protein ingestion. Despite evidence of increased rate of digestion and leucine availability following the ingestion of whey protein, there was similar activation of MPS in middle-aged men with either 20 g of milk protein or whey protein. PMID:26506377

  8. Glasshouse vs field experiments: do they yield ecologically similar results for assessing N impacts on peat mosses?

    PubMed

    Limpens, J; Granath, G; Aerts, R; Heijmans, M M P D; Sheppard, L J; Bragazza, L; Williams, B L; Rydin, H; Bubier, J; Moore, T; Rochefort, L; Mitchell, E A D; Buttler, A; van den Berg, L J L; Gunnarsson, U; Francez, A-J; Gerdol, R; Thormann, M; Grosvernier, P; Wiedermann, M M; Nilsson, M B; Hoosbeek, M R; Bayley, S; Nordbakken, J-F; Paulissen, M P C P; Hotes, S; Breeuwer, A; Ilomets, M; Tomassen, H B M; Leith, I; Xu, B

    2012-07-01

    • Peat bogs have accumulated more atmospheric carbon (C) than any other terrestrial ecosystem today. Most of this C is associated with peat moss (Sphagnum) litter. Atmospheric nitrogen (N) deposition can decrease Sphagnum production, compromising the C sequestration capacity of peat bogs. The mechanisms underlying the reduced production are uncertain, necessitating multifactorial experiments. • We investigated whether glasshouse experiments are reliable proxies for field experiments for assessing interactions between N deposition and environment as controls on Sphagnum N concentration and production. We performed a meta-analysis over 115 glasshouse experiments and 107 field experiments. • We found that glasshouse and field experiments gave similar qualitative and quantitative estimates of changes in Sphagnum N concentration in response to N application. However, glasshouse-based estimates of changes in production--even qualitative assessments-- diverged from field experiments owing to a stronger N effect on production response in absence of vascular plants in the glasshouse, and a weaker N effect on production response in presence of vascular plants compared to field experiments. • Thus, although we need glasshouse experiments to study how interacting environmental factors affect the response of Sphagnum to increased N deposition, we need field experiments to properly quantify these effects. PMID:22537052

  9. Prepubertal goat oocytes from large follicles result in similar blastocyst production and embryo ploidy than those from adult goats.

    PubMed

    Romaguera, R; Moll, X; Morató, R; Roura, M; Palomo, M J; Catalá, M G; Jiménez-Macedo, A R; Hammami, S; Izquierdo, D; Mogas, T; Paramio, M T

    2011-07-01

    Developmental competence of oocytes from prepubertal females is lower than those from adult females. Oocyte development competence is positively related to follicular diameter. Most of the follicles of prepubertal goat ovaries are smaller than 3 mm. The aim of this study was to compare oocytes of two follicle sizes (< 3 mm and ≥ 3 mm) from prepubertal goats with oocytes from adult goats in relation to their in vitro production and quality of blastocysts. Oocytes from prepubertal goats were obtained from slaughterhouse ovaries and selected according to the follicle diameter whereas oocytes from adult goats were recovered in vivo by LOPU technique without prior selection of follicle size. COCs were IVM for 27 h, IVF at the conventional conditions with fresh semen and presumptive zygotes were cultured in SOF medium for 8 days. Blastocysts obtained were vitrified and after warming their blastocoele re-expansion and the ploidy by FISH technique were assessed. We found significant differences between blastocysts yield of oocytes recovered from follicles smaller than 3 mm of prepubertal goats compared to those from adult goats (5.45% vs 20. 83%, respectively) however, these differences disappear if oocytes were recovered form large follicles (18.07%). A total of 28 blastocysts were analysed and 96.43% showed mixoploidy. Age did not affect the number of embryos with abnormal ploidy or blastocyst re-expansion after warming. Furthermore, the percentage of diploid blastomeres per embryo was similar in the 3 groups studied, adult, prepubertal from follicles ≥ 3 mm and < 3 mm (68.6%, 80.8% and 73.6%, respectively). In conclusion, IVP of blastocysts coming from follicles larger than 3 mm of goats 45 days old were not different to the blastocysts produced from adult goats, both in terms of quantity and quality.

  10. Memories of traumatic events in childhood fade after experiencing similar less stressful events: results from two natural experiments.

    PubMed

    Weems, Carl F; Russell, Justin D; Banks, Donice M; Graham, Rebecca A; Neill, Erin L; Scott, Brandon G

    2014-10-01

    The long-term stability of youth reports of traumatic events is largely unknown. Translational animal research suggests that there may be an alteration of memories for traumatic events via memory reconsolidation processes, whereas clinical research suggests memory alteration may occur through augmentation by negative emotions. In this report, 2 natural experiments test reconsolidation model and augmentation model predictions about the course of traumatic memories in youth. Data are from 2 prospective studies that assessed reports of an initial traumatic event (Hurricane Katrina) and tested recall both pre and post a similar event (Hurricane Gustav). In the 1st (Sample 1; n = 94, initial Grade 9 followed to 11), youth were assessed at 4 time points: Times 1-3 were 13, 20, and 26 months post-Katrina and then Time 4 was 5 months post-Hurricane Gustav. In the 2nd (Sample 2; n = 141, Grades 4 through 8), youth were assessed at 12 months pre-Gustav (Time 1; 24 months post-Katrina) and then again at 1 month (Time 2) and 8 months (Time 3) post-Gustav. Those with relatively high Gustav exposure showed more stability in their reports of Katrina exposure events, whereas in those with low Gustav exposure, reports of Katrina events decreased. Time spans between recall, age, gender, symptoms of posttraumatic stress disorder, or cognitive/learning ability did not explain changes in the reports. The study provides the 1st long-term data on the consistency of youth reports of disaster-related experiences and provides initial evidence for the ecological validity of memory reconsolidation theory applied to traumatic events in youth. PMID:25068536

  11. Memories of traumatic events in childhood fade after experiencing similar less stressful events: results from two natural experiments.

    PubMed

    Weems, Carl F; Russell, Justin D; Banks, Donice M; Graham, Rebecca A; Neill, Erin L; Scott, Brandon G

    2014-10-01

    The long-term stability of youth reports of traumatic events is largely unknown. Translational animal research suggests that there may be an alteration of memories for traumatic events via memory reconsolidation processes, whereas clinical research suggests memory alteration may occur through augmentation by negative emotions. In this report, 2 natural experiments test reconsolidation model and augmentation model predictions about the course of traumatic memories in youth. Data are from 2 prospective studies that assessed reports of an initial traumatic event (Hurricane Katrina) and tested recall both pre and post a similar event (Hurricane Gustav). In the 1st (Sample 1; n = 94, initial Grade 9 followed to 11), youth were assessed at 4 time points: Times 1-3 were 13, 20, and 26 months post-Katrina and then Time 4 was 5 months post-Hurricane Gustav. In the 2nd (Sample 2; n = 141, Grades 4 through 8), youth were assessed at 12 months pre-Gustav (Time 1; 24 months post-Katrina) and then again at 1 month (Time 2) and 8 months (Time 3) post-Gustav. Those with relatively high Gustav exposure showed more stability in their reports of Katrina exposure events, whereas in those with low Gustav exposure, reports of Katrina events decreased. Time spans between recall, age, gender, symptoms of posttraumatic stress disorder, or cognitive/learning ability did not explain changes in the reports. The study provides the 1st long-term data on the consistency of youth reports of disaster-related experiences and provides initial evidence for the ecological validity of memory reconsolidation theory applied to traumatic events in youth.

  12. Correlation Between Geometric Similarity of Ice Shapes and the Resulting Aerodynamic Performance Degradation: A Preliminary Investigation Using WIND

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Chung, James

    1999-01-01

    Aerodynamic performance calculations were performed using WIND on ten experimental ice shapes and the corresponding ten ice shapes predicted by LEWICE 2.0. The resulting data for lift coefficient and drag coefficient are presented. The difference in aerodynamic results between the experimental ice shapes and the LEWICE ice shapes were compared to the quantitative difference in ice shape geometry presented in an earlier report. Correlations were generated to determine the geometric features which have the most effect on performance degradation. Results show that maximum lift and stall angle can be correlated to the upper horn angle and the leading edge minimum thickness. Drag coefficient can be correlated to the upper horn angle and the frequency-weighted average of the Fourier coefficients. Pitching moment correlated with the upper horn angle and to a much lesser extent to the upper and lower horn thicknesses.

  13. Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation

    SciTech Connect

    Corral, J.; Forster, A.; Thompson, S.; Rabbitts, T.H. ); Lampert, F. ); Kaneko, Y. ); Slater, R.; Kroes, W.G. ); Van Der Schoot, C.E. ); Ludwig, W.D. ); Karpas, A. ); Pocock, C.; Cotter, F. )

    1993-09-15

    The MLL gene, on human chromosome 11q23, undergoes chromosomal translocation in acute leukemias, resulting in gene fusion with AF4 (chromosome 4) and ENL (chromosome 19). The authors report here translocation of MLL with nine different chromosomes and two paracentric chromosome 11 deletions in early B cell, B- or T-cell lineage, or nonlymphocytic acute leukemias. The mRNA translocation junction from 22t(4;11) patients, including six adult leukemias, and nine t(11;19) tumors reveals a remarkable conservation of breakpoints within MLL, AF4, or ENL genes, irrespective of tumor phenotype. Typically, the breakpoints are upstream of the zinc-finger region of MLL, and deletion of this region can accompany translocation, supporting the der(11) chromosome as the important component in leukemogenesis. Partial sequence of a fusion between MLL and the AFX1 gene from chromosome X shows the latter to be rich in Ser/Pro codons, like the ENL mRNA. These data suggest that the heterogeneous 11q23 abnormalities might cause attachment of Ser/Pro-rich segments to the NH[sub 2] terminus of MLL, lacking the zinc-finger region, and that translocation occurs in early hematopoietic cells, before commitment to distinct lineages. 36 refs., 2 figs.

  14. Wind Energy Program: Top 10 Program Accomplishments

    SciTech Connect

    2009-01-18

    Brochure on the top accomplishments of the Wind Energy Program, including the development of large wind machines, small machines for the residential market, wind tunnel testing, computer codes for modeling wind systems, high definition wind maps, and successful collaborations.

  15. Accomplishments of Science by the Year 2000

    NASA Technical Reports Server (NTRS)

    Bergman, J.

    1985-01-01

    Current and projected accomplishments in science and technology are examined from a social and political perspective. It is observed that the present level of research and development in the United States is inadequate for many possible advancements to occur.

  16. A small spacecraft mission with large accomplishments

    NASA Astrophysics Data System (ADS)

    Baker, Daniel N.; Mason, Glenn M.; Mazur, Joseph E.

    2012-08-01

    A remarkable era of space research will end soon when, after 20 years of space-based observations, the Solar, Anomalous, and Magnetospheric Particle Explorer (SAMPEX) spacecraft will reenter Earth's atmosphere. This will result from the resurgence of the Sun's activity and the related increase of atmospheric drag produced by increasing solar ultraviolet radiation. The best estimate is that SAMPEX will succumb to drag forces (and burn up on reentry) in late September 2012, but this could occur as early as August or as late as December 2012 [see Baker et al., 2012]. SAMPEX has been a pacesetting mission since its inception. It was selected in 1989 for flight as NASA's first spacecraft in the "Small Explorer" (SMEX) program [Baker et al., 1993]. The SMEX program was intended both to accomplish forefront science (at a very affordable cost) as well as to provide a training ground in the best space development practices for a new generation of scientists, engineers, and managers. As its full name suggests, SAMPEX was always intended to perform multiple duties and was geared toward making measurements in space of moderate to very high energy particles [see Baker et al., 1993]. A few of the key contributions made by the SAMPEX program are summarized below.

  17. Engineering Accomplishments in the Construction of NCSX

    SciTech Connect

    G. H. Neilson; P.J. Heitzenroeder; B.E. Nelson; W.T. Reiersen; A. Brooks; T.G. Brown; J.H. Chrzanowski; M.J. Cole; F. Dahlgren; T. Dodson; L.E. Dudek; R.A. Ellis; H.M. Fan; P.J. Fogarty; K.D. Freudenberg; P.L. Goranson; J.H. Harris; M.R. Kalish; G. Labik; J.F. Lyon; N. Pomphrey; C.D. Priniski; S. Raftopoulos; D.J. Rej; W.R. Sands; R.T. Simmons; B.E. Stratton; R.L. Strykowsky; M.E. Viola; D.E. Williamson; M.C. Zarnstorff

    2008-09-01

    The National Compact Stellarator Experiment (NCSX) was designed to test a compact, quasiaxisymmetric stellarator configuration. Flexibility and accurate realization of its complex 3D geometry were key requirements affecting the design and construction. While the project was terminated before completing construction, there were significant engineering accomplishments in design, fabrication, and assembly. The design of the stellarator core device was completed. All of the modular coils, toroidal field coils, and vacuum vessel sectors were fabricated. Critical assembly steps were demonstrated. Engineering advances were made in the application of CAD modeling, structural analysis, and accurate fabrication of complex-shaped components and subassemblies. The engineering accomplishments of the project are summarized

  18. Accomplished Teachers Implementation of Quality Teaching Practices

    ERIC Educational Resources Information Center

    Chen, Weiyun; Hammond-Bennett, Austin; Upton, Ashely; Mason, Steve

    2014-01-01

    The purpose of this study was to describe how accomplished teachers implement the quality of teaching practices in their daily lessons. The participants were four elementary physical education teachers (one male, three female). The data sources consisted of videotape of the teachers teaching 12 lessons, transcription of the taped lessons,…

  19. Acoustics Division recent accomplishments and research plans

    NASA Technical Reports Server (NTRS)

    Clark, L. R.; Morgan, H. G.

    1986-01-01

    The research program currently being implemented by the Acoustics Division of NASA Langley Research Center is described. The scope, focus, and thrusts of the research are discussed and illustrated for each technical area by examples of recent technical accomplishments. Included is a list of publications for the last two calendar years. The organization, staff, and facilities are also briefly described.

  20. Biomass Program 2007 Accomplishments - Report Introduction

    SciTech Connect

    none,

    2009-10-27

    The Office of Energy Efficiency and Renewable Energy's (EERE’s) Biomass Program works with industry, academia and its national laboratory partners on a balanced portfolio of research in biomass feedstocks and conversion technologies. This document provides the introduction to the 2007 Program Accomplishments Report.

  1. Biomass Program 2007 Accomplishments - Full Report

    SciTech Connect

    none,

    2009-10-27

    The Office of Energy Efficiency and Renewable Energy's (EERE’s) Biomass Program works with industry, academia and its national laboratory partners on a balanced portfolio of research in biomass feedstocks and conversion technologies. This document provides Program accomplishments for 2007.

  2. Accomplishing Multiple Goals through Community Connections

    ERIC Educational Resources Information Center

    Stone, Jody

    2007-01-01

    With schools being asked to accomplish more and more, it is increasingly important to, whenever possible, address multiple goals in teaching. Educating the whole child dictates that we find ways to ensure our graduates are well-rounded, independent thinkers capable of becoming well-adjusted, contributing adults. Thus community service has become a…

  3. 2014 Survey of States: Initiatives, Trends, and Accomplishments

    ERIC Educational Resources Information Center

    Shyyan, Vitaliy; Lazarus, Sheryl S.; Thurlow, Martha L.

    2015-01-01

    This report summarizes the fourteenth survey of states by the National Center on Educational Outcomes (NCEO) at the University of Minnesota. Results are presented for the 50 regular states and eight of the 11 unique states. The purpose of this report is to provide a snapshot of the new initiatives, trends, accomplishments, and emerging issues…

  4. Enhanced surveillance program FY1998 accomplishments

    SciTech Connect

    Kass, J

    1998-10-01

    This report highlights the accomplishments of the Enhanced Surveillance Program (ESP), the highest-priority research and development effort in stockpile management today. This is volume one of eleven, the unclassified summary of selected program highlights. These highlights fall into the following focus areas: pits, high explosives, organics, dynamics, diagnostics, systems, secondaries, materials-aging models, non-nuclear components, and routine surveillance testing system upgrades. Principal investigators from around the DOE complex contributed to this report.

  5. NASA total quality management 1990 accomplishments report

    NASA Technical Reports Server (NTRS)

    1991-01-01

    NASA's efforts in Total Quality Management are based on continuous improvement and serve as a foundation for NASA's present and future endeavors. Given here are numerous examples of quality strategies that have proven effective and efficient in a time when cost reduction is critical. These accomplishment benefit our Agency and help to achieve our primary goal, keeping American in the forefront of the aerospace industry.

  6. Significant Accomplishments in Science and Technology

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The proceedings of a symposium on significant accomplishments in science and technology are presented. The symposium was held at the Goddard Space Flight Center in December 1973. The subjects discussed are as follows: (1) cometary physics, (2) X-ray and gamma ray astronomy, (3) solar and terrestrial physics, (4) spacecraft technology, (5) Earth Resources Technology Satellite, (6) earth and ocean physics, (6) communications and navigation, (7) mission operations and data systems, and (8) networks systems and operations.

  7. Light Water Reactor Sustainability Accomplishments Report

    SciTech Connect

    McCarthy, Kathryn A.

    2015-02-01

    Welcome to the 2014 Light Water Reactor Sustainability (LWRS) Program Accomplishments Report, covering research and development highlights from 2014. The LWRS Program is a U.S. Department of Energy research and development program to inform and support the long-term operation of our nation’s commercial nuclear power plants. The research uses the unique facilities and capabilities at the Department of Energy national laboratories in collaboration with industry, academia, and international partners. Extending the operating lifetimes of current plants is essential to supporting our nation’s base load energy infrastructure, as well as reaching the Administration’s goal of reducing greenhouse gas emissions to 80% below 1990 levels by the year 2050. The purpose of the LWRS Program is to provide technical results for plant owners to make informed decisions on long-term operation and subsequent license renewal, reducing the uncertainty, and therefore the risk, associated with those decisions. In January 2013, 104 nuclear power plants operated in 31 states. However, since then, five plants have been shut down (several due to economic reasons), with additional shutdowns under consideration. The LWRS Program aims to minimize the number of plants that are shut down, with R&D that supports long-term operation both directly (via data that is needed for subsequent license renewal), as well indirectly (with models and technology that provide economic benefits). The LWRS Program continues to work closely with the Electric Power Research Institute (EPRI) to ensure that the body of information needed to support SLR decisions and actions is available in a timely manner. This report covers selected highlights from the three research pathways in the LWRS Program: Materials Aging and Degradation, Risk-Informed Safety Margin Characterization, and Advanced Instrumentation, Information, and Control Systems Technologies, as well as a look-ahead at planned activities for 2015. If you

  8. Advanced Fuels Campaign FY 2015 Accomplishments Report

    SciTech Connect

    Braase, Lori Ann; Carmack, William Jonathan

    2015-10-29

    The mission of the Advanced Fuels Campaign (AFC) is to perform research, development, and demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This report is a compilation of technical accomplishment summaries for FY-15. Emphasis is on advanced accident-tolerant LWR fuel systems, advanced transmutation fuels technologies, and capability development.

  9. Sandia technology engineering and science accomplishments

    SciTech Connect

    Not Available

    1993-03-01

    Sandia is a DOE multiprogram engineering and science laboratory with major facilities at Albuquerque, New Mexico, and Livermore, California, and a test range near Tonapah, Nevada. We have major research and development responsibilities for nuclear weapons, arms control, energy, the environment, economic competitiveness, and other areas of importance to the needs of the nation. Our principal mission is to support national defense policies by ensuring that the nuclear weapon stockpile meets the highest standards of safety, reliability, security, use control, and military performance. Selected unclassified technical activities and accomplishments are reported here. Topics include advanced manufacturing technologies, intelligent machines, computational simulation, sensors and instrumentation, information management, energy and environment, and weapons technology.

  10. Similar names for similar biologics.

    PubMed

    Casadevall, Nicole; Felix, Thomas; Strober, Bruce E; Warnock, David G

    2014-10-01

    Approval of the first biosimilar in the USA may occur by the end of 2014, yet a naming approach for biosimilars has not been determined. Biosimilars are highly similar to their biologic reference product but are not identical to it, because of their structural complexity and variations in manufacturing processes among companies. There is a need for a naming approach that can distinguish a biosimilar from its reference product and other biosimilars and ensure accurate tracing of adverse events (AEs) to the administered product. In contrast, generic small-molecule drugs are identical to their reference product and, therefore, share the same nonproprietary name. Clinical trials required to demonstrate biosimilarity for approval may not detect rare AEs or those occurring after prolonged use, and the incidence of such events may differ between a biosimilar and its reference product. The need for precise biologic identification is further underscored by the possibility of biosimilar interchangeability, a US designation that will allow substitution without prescriber intervention. For several biologics, the US Food and Drug Administration (FDA) has used a naming approach that adds a prefix to a common root nonproprietary name, enabling healthcare providers to distinguish between products, avoid medication errors, and facilitate pharmacovigilance. We recommend that the FDA implement a biosimilars naming policy that likewise would add a distinguishable prefix or suffix to the root nonproprietary name of the reference product. This approach would ensure that a biosimilar could be distinguished from its reference product and other biosimilars in patient records and pharmacovigilance databases/reports, facilitating accurate attribution of AEs. PMID:25001080

  11. Low Cost Methods to Accomplish Aeronomy Science

    NASA Astrophysics Data System (ADS)

    Swenson, G. R.

    2013-12-01

    Accomplishment of aeronomy science using low cost methods involves a number of innovative considerations. These methods will be discussed. They include making broad use of internet to control and operate distributed sensors. Sensor controls should be simple and most important reliable. Imagers are a common sensor for optical systems and include common computer interfaces and menu driven operations which often don't require special software or engineering development. Small, inexpensive but reliable satellite systems are evolving in the Cubesat community. Effective use of students is invaluable, giving them responsibility to operate instrumentation and to routinely archive the data. Management of students is especially important in the early phase of their training to insure quality performance. These ideas will be elaborated on, and most importantly, the science motive is the most important driver for what is done.

  12. Health and Environmental Research. Summary of Accomplishments

    DOE R&D Accomplishments Database

    1984-04-01

    This is a short account of a 40-year-old health and environmental research program performed in national laboratories, universities, and research institutes. Under the sponsorship of the federal agencies that were consecutively responsible for the national energy mission, this research program has contributed to the understanding of the human health and environmental effects of emergining energy technologies. In so doing, it has also evolved several nuclear techniques for the diagnosis and treatment of human ills. The form of this presentation is through examples of significant, tangible accomplishments in each of these areas at certain times to illustrate the role and impact of the research program. The narrative of this research program concludes with a perspective of its past and a prospectus on its future.

  13. NASA total quality management 1989 accomplishments report

    NASA Technical Reports Server (NTRS)

    Tai, Betty P. (Editor); Stewart, Lynne M. (Editor)

    1990-01-01

    NASA and contractor employees achieved many notable improvements in 1989. The highlights of those improvements, described in this seventh annual Accomplishments Report, demonstrate that the people who support NASA's activities are getting more involved in quality and continuous improvement efforts. Their gains solidly support NASA's and this Nation's goal to remain a leader in space exploration and in world-wide market competition, and, when communicated to others through avenues such as this report, foster improvement efforts across government and industry. The principles in practice which led to these process refinements are important cultural elements to any organization's productivity and quality efforts. The categories in this report reflect NASA principles set forth in the 1980's and are more commonly known today as Total Quality Management (TQM): top management leadership and support; strategic planning; focus on the customer; employee training and recognition; employee empowerment and teamwork; measurement and analysis; and quality assurance.

  14. Health and environmental research. Summary of accomplishments

    SciTech Connect

    Not Available

    1984-04-01

    This is a short account of a 40-year-old health and environmental research program performed in national laboratories, universities, and research institutes. Under the sponsorship of the federal agencies that were consecutively responsible for the national energy mission, this research program has contributed to the understanding of the human health and environmental effects of emergining energy technologies. In so doing, it has also evolved several nuclear techniques for the diagnosis and treatment of human ills. The form of this presentation is through examples of significant, tangible accomplishments in each of these areas at certain times to illustrate the role and impact of the research program. The narrative of this research program concludes with a perspective of its past and a prospectus on its future.

  15. Psychotherapy reflections: what I seek to accomplish in psychotherapy sessions.

    PubMed

    Tryon, Georgiana Shick

    2013-09-01

    I discuss the three things that I want to accomplish in each psychotherapy session from the theoretical orientation of a cognitive-behavioral psychotherapist. They are to establish collaboration, goal consensus, and engagement with the patient. I indicate my approach to these therapy elements in the beginning, middle, and end of sessions, and provide background information and theory, fabricated case examples, and research results for each element.

  16. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals.

    PubMed

    Martins, Catia; Kazakova, Irina; Ludviksen, Marit; Mehus, Ingar; Wisloff, Ulrik; Kulseng, Bard; Morgan, Linda; King, Neil

    2016-06-01

    This study aimed to determine the effects of 12 weeks of isocaloric programs of high-intensity intermittent training (HIIT) or moderate-intensity continuous training (MICT) or a short-duration HIIT (1/2HIIT) inducing only half the energy deficit on a cycle ergometer, on body weight and composition, cardiovascular fitness, resting metabolism rate (RMR), respiratory exchange ratio (RER), nonexercise physical activity (PA) levels and fasting and postprandial insulin response in sedentary obese individuals. Forty-six sedentary obese individuals (30 women), with a mean BMI of 33.3 ± 2.9 kg/m2 and a mean age of 34.4 ± 8.8 years were randomly assigned to one of the three training groups: HIIT (n = 16), MICT (n = 14) or 1/2HIIT (n = 16) and exercise was performed 3 times/week for 12 weeks. Overall, there was a significant reduction in body weight, waist (p < .001) and hip (p < .01) circumference,, trunk and leg fat mass (FM; p < .01) and an increase in trunk and leg fat free mass (FFM; p < .01) and cardiovascular fitness (VO2max in ml/kg/min; p < .001) with exercise. However, no significant differences were observed between groups. There was no significant change in RMR, RER, nonexercise PA levels, fasting insulin or insulin sensitivity with exercise or between groups. There was a tendency for a reduction in AUC insulin with exercise (p = .069), but no differences between groups. These results indicate that isocaloric training protocols of HIIT or MICT (or 1/2HIIT inducing only half the energy deficit) exert similar metabolic and cardiovascular improvements in sedentary obese individuals.

  17. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals.

    PubMed

    Martins, Catia; Kazakova, Irina; Ludviksen, Marit; Mehus, Ingar; Wisloff, Ulrik; Kulseng, Bard; Morgan, Linda; King, Neil

    2016-06-01

    This study aimed to determine the effects of 12 weeks of isocaloric programs of high-intensity intermittent training (HIIT) or moderate-intensity continuous training (MICT) or a short-duration HIIT (1/2HIIT) inducing only half the energy deficit on a cycle ergometer, on body weight and composition, cardiovascular fitness, resting metabolism rate (RMR), respiratory exchange ratio (RER), nonexercise physical activity (PA) levels and fasting and postprandial insulin response in sedentary obese individuals. Forty-six sedentary obese individuals (30 women), with a mean BMI of 33.3 ± 2.9 kg/m2 and a mean age of 34.4 ± 8.8 years were randomly assigned to one of the three training groups: HIIT (n = 16), MICT (n = 14) or 1/2HIIT (n = 16) and exercise was performed 3 times/week for 12 weeks. Overall, there was a significant reduction in body weight, waist (p < .001) and hip (p < .01) circumference,, trunk and leg fat mass (FM; p < .01) and an increase in trunk and leg fat free mass (FFM; p < .01) and cardiovascular fitness (VO2max in ml/kg/min; p < .001) with exercise. However, no significant differences were observed between groups. There was no significant change in RMR, RER, nonexercise PA levels, fasting insulin or insulin sensitivity with exercise or between groups. There was a tendency for a reduction in AUC insulin with exercise (p = .069), but no differences between groups. These results indicate that isocaloric training protocols of HIIT or MICT (or 1/2HIIT inducing only half the energy deficit) exert similar metabolic and cardiovascular improvements in sedentary obese individuals. PMID:26479856

  18. Fort Collins Science Center: 2006 Accomplishments

    USGS Publications Warehouse

    Wilson, Juliette T.

    2007-01-01

    In Fiscal Year 2006 (FY06), the U.S. Geological Survey (USGS) Fort Collins Science Center (FORT) continued research vital to U.S. Department of the Interior (DOI) science and management needs and associated USGS programmatic goals. FORT work also supported the science needs of other governmental departments and agencies as well as private cooperators. Specifically, FORT scientific research and technical assistance focused on client and partner agency needs and goals in the areas of biological information management, fisheries and aquatic systems, invasive species, status and trends of biological resources, terrestrial ecosystems, and wildlife resources. Highlights of FORT project accomplishments are described below under the USGS science program area with which each task is most closely associated.2 The work of FORT’s five branches (in 2006: Aquatic Systems and Technology Applications, Ecosystem Dynamics, Invasive Species Science, Policy Analysis and Science Assistance, and Species and Habitats of Federal Interest) often involves major partnerships with other agencies or cooperation with other USGS disciplines (Geology, Geography, Water Resources).

  19. Impacting Teachers' Understanding of Geometric Similarity: Results from Field Testing of the Learning and Teaching Geometry Professional Development Materials

    ERIC Educational Resources Information Center

    Seago, Nanette M.; Jacobs, Jennifer K.; Heck, Daniel J.; Nelson, Courtney L.; Malzahn, Kristen A.

    2014-01-01

    The main goal of the Learning and Teaching Geometry project is to build professional development materials that provide opportunities for teachers to learn about mathematical similarity through the use of videocases, in which specific and increasingly complex mathematical ideas are presented within the dynamics of classroom practice. The central…

  20. Lunabotics Mining Competition: Inspiration Through Accomplishment

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.

    2011-01-01

    NASA's Lunabotics Mining Competition is designed to promote the development of interest in space activities and STEM (Science, Technology, Engineering, and Mathematics) fields. The competition uses excavation, a necessary first step towards extracting resources from the regolith and building bases on the moon. The unique physical properties of lunar regolith and the reduced 1/6th gravity, vacuum environment make excavation a difficult technical challenge. Advances in lunar regolith mining have the potential to significantly contribute to our nation's space vision and NASA space exploration operations. The competition is conducted annually by NASA at the Kennedy Space Center Visitor Complex. The teams that can use telerobotic or autonomous operation to excavate a lunar regolith geotechnical simulant, herein after referred to as Black Point-1 (or BP-1) and score the most points (calculated as an average of two separate 10-minute timed competition attempts) will eam points towards the Joe Kosmo Award for Excellence and the scores will reflect ranking in the on-site mining category of the competition. The minimum excavation requirement is 10.0 kg during each competition attempt and the robotic excavator, referred to as the "Lunabot", must meet all specifications. This paper will review the achievements of the Lunabotics Mining Competition in 2010 and 2011, and present the new rules for 2012. By providing a framework for robotic design and fabrication, which culminates in a live competition event, university students have been able to produce sophisticated lunabots which are tele-operated. Multi-disciplinary teams are encouraged and the extreme sense of accomplishment provides a unique source of inspiration to the participating students, which has been shown to translate into increased interest in STEM careers. Our industrial sponsors (Caterpillar, Newmont Mining, Harris, Honeybee Robotics) have all stated that there is a strong need for skills in the workforce related

  1. Some History and Accomplishments of the IUSS

    NASA Astrophysics Data System (ADS)

    Brevik, Eric C.; Hartemink, Alfred E.

    2013-04-01

    Urban Soils) and three standing committees (Committee on awards and prizes, Committee on budget and finances, and Committee on statutes and byelaws). Membership in ISSS/IUSS increased from around 550 after WWII to over 60,000 today. The IUSS also provides Honorary Membership to soil scientists who have significant accomplishments in the field; to date 87 soil scientists have been so recognized from all over the globe. The IUSS is the most important global link to the world's leading soil science and soil scientists.

  2. APPLYING SIMPLE TECHNOLOGY ACCOMPLISHES VISUAL INSPECTION CHALLENGES

    SciTech Connect

    Robinson, C

    2007-07-21

    This paper discusses the successful implementation of simple video technologies at the Savannah River Site (SRS) to perform complex visual inspection, monitoring, and surveillance tasks. Because SRS facilities are similar to those of an industrial plant, the environmental and accessibility considerations for remote viewing are the primary determining factors in the selection of technology. The constraints and challenges associated with remote viewing are discussed, and examples of applications are given.

  3. The mastodon mitochondrial genome: a mammoth accomplishment.

    PubMed

    Roca, Alfred L

    2008-02-01

    The mitochondrial genome of an American mastodon was recently sequenced and used to root a phylogenetic analysis that included full mitochondrial genome sequences from woolly mammoths and the two living elephant genera. The study definitively established that mammoth and Asian elephant mitochondrial DNA lineages are more closely related than either is to African elephants. However, it also suggests that a complex evolutionary picture could ultimately emerge and points to similarities between the early evolution of the Elephantidae and that of the gorilla-human-chimpanzee clade. PMID:18192067

  4. Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism

    PubMed Central

    Meneely, Kathleen M.; Luo, Qianyi; Riley, Andrew P.; Taylor, Byron; Roy, Anuradha; Stein, Ross L.; Prisinzano, Thomas E.; Lamb, Audrey L.

    2014-01-01

    Antibiotic resistance is a growing health concern, and new avenues of antimicrobial drug design are being actively sought. One suggested pathway to be targeted for inhibitor design is that of iron scavenging through siderophores. Here we present a high throughput screen to the isochorismate-pyruvate lyase of Pseudomonas aeruginosa, an enzyme required for the production of the siderophore pyochelin. Compounds identified in the screen are high nanomolar to low micromolar inhibitors of the enzyme and produce growth inhibition in PAO1 P. aeruginosa in the millimolar range under iron-limiting conditions. The identified compounds were also tested for enzymatic inhibition of E. coli chorismate mutase, a protein of similar fold and similar chemistry, and of Y. enterocolitica salicylate synthase, a protein of differing fold but catalyzing the same lyase reaction. In both cases, subsets of the inhibitors from the screen were found to be inhibitory to enzymatic activity (mutase or synthase) in the micromolar range and capable of growth inhibition in their respective organisms (E. coli or Y. enterocolitica). PMID:25282647

  5. Oocyte maturation and fertilization in marine nemertean worms: using similar sorts of signaling pathways as in mammals, but often with differing results.

    PubMed

    Stricker, Stephen A; Cline, Cory; Goodrich, David

    2013-08-01

    In marine worms belonging to the phylum Nemertea, oocyte maturation and fertilization are regulated by the same general kinds of signals that control such processes in mammals. However, unlike mammalian oocytes that develop within follicles, nemertean oocytes characteristically lack a surrounding sheath of follicle cells and often respond differently to maturation-related cues than do mammalian oocytes. For example, elevators of cyclic adenosine monophosphate (cAMP) or cyclic guanosine monophosphate (cGMP) levels promote the resumption of meiotic maturation (=germinal vesicle breakdown, GVBD) in nemertean oocytes, whereas increasing intraoocytic cAMP and cGMP typically blocks GVBD in mammals. Similarly, AMP-activated kinase (AMPK) signaling keeps nemertean oocytes from maturing, but in mouse oocytes, AMPK activation triggers GVBD. In addition, protein kinase C (PKC) activity is required for seawater-induced GVBD in nemerteans, whereas some PKCs have been shown to inhibit GVBD in mammals. Furthermore, although fertilization causes both types of oocytes to reorganize their endoplasmic reticulum and generate calcium oscillations that can involve soluble sperm factor activity and inositol 1,4,5-trisphosphate signaling, some discrepancies in the spatiotemporal patterns and underlying mechanisms of fertilization are also evident in nemerteans versus mammals. Thus, to characterize differences and similarities in gamete biology more fully, aspects of oocyte maturation and fertilization in marine nemertean worms are reviewed and briefly compared with related findings that have been published for mammalian oocytes. In addition, possible causes of the alternative responses displayed by oocytes in these two animal groups are addressed.

  6. Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.

    PubMed

    Meneely, Kathleen M; Luo, Qianyi; Riley, Andrew P; Taylor, Byron; Roy, Anuradha; Stein, Ross L; Prisinzano, Thomas E; Lamb, Audrey L

    2014-11-01

    Antibiotic resistance is a growing health concern, and new avenues of antimicrobial drug design are being actively sought. One suggested pathway to be targeted for inhibitor design is that of iron scavenging through siderophores. Here we present a high throughput screen to the isochorismate-pyruvate lyase of Pseudomonas aeruginosa, an enzyme required for the production of the siderophore pyochelin. Compounds identified in the screen are high nanomolar to low micromolar inhibitors of the enzyme and produce growth inhibition in PAO1 P. aeruginosa in the millimolar range under iron-limiting conditions. The identified compounds were also tested for enzymatic inhibition of Escherichia coli chorismate mutase, a protein of similar fold and similar chemistry, and of Yersinia enterocolitica salicylate synthase, a protein of differing fold but catalyzing the same lyase reaction. In both cases, subsets of the inhibitors from the screen were found to be inhibitory to enzymatic activity (mutase or synthase) in the micromolar range and capable of growth inhibition in their respective organisms (E. coli or Y. enterocolitica). PMID:25282647

  7. Material Recovery and Waste Form Development FY 2015 Accomplishments Report

    SciTech Connect

    Todd, Terry Allen; Braase, Lori Ann

    2015-11-01

    The Material Recovery and Waste Form Development (MRWFD) Campaign under the U.S. Department of Energy (DOE) Fuel Cycle Technologies (FCT) Program is responsible for developing advanced separation and waste form technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The FY 2015 Accomplishments Report provides a highlight of the results of the research and development (R&D) efforts performed within the MRWFD Campaign in FY-14. Each section contains a high-level overview of the activities, results, technical point of contact, applicable references, and documents produced during the fiscal year. This report briefly outlines campaign management and integration activities, but primarily focuses on the many technical accomplishments made during FY-15. The campaign continued to utilize an engineering driven-science-based approach to maintain relevance and focus. There was increased emphasis on development of technologies that support near-term applications that are relevant to the current once-through fuel cycle.

  8. X-RAY SELECTED AGN HOST GALAXIES ARE SIMILAR TO INACTIVE GALAXIES OUT TO z = 3: RESULTS FROM CANDELS/CDF-S

    SciTech Connect

    Rosario, D. J.; Wuyts, S.; Nandra, K.; Mozena, M.; Faber, S. M.; Koo, D. C.; Koekemoer, A.; Ferguson, H.; Grogin, N.; McGrath, E.; Hathi, N. P.; Dekel, A.; Donley, J.; Dunlop, J. S.; Giavalisco, M.; Guo, Y.; Kocevski, D. D.; Laird, E.; Rangel, C.; Newman, J.; and others

    2013-01-20

    We use multi-band spatially resolved photometry from the Cosmic Assembly Near-IR Deep Legacy Survey in the 4 Ms Chandra Deep Field-South to explore the nuclear and extended colors, color gradients, and stellar populations of the host galaxies of X-ray selected active galactic nuclei (AGNs) out to z = 3. Based on a study of their central light, we develop X-ray based criteria to exclude objects with strong AGN contamination. We use stellar masses from the FIREWORKS database to understand and account for stellar mass selection effects and carefully study, for the first time, the resolved host galaxy properties of AGNs at z {approx} 2 in their rest-frame optical light without substantial nuclear contamination. AGN hosts span a sizable range of stellar masses, colors, and color gradients at these redshifts. Their colors, color gradients, and stellar population properties are very similar to inactive galaxies of the same stellar mass. At z {approx} 1, we find a slightly narrower range in host colors compared to inactive galaxies, as well as hints of more recent star formation. These differences are weaker or non-existent among AGN hosts at z {approx} 2. We discuss the importance of AGN-driven feedback in the quenching of galaxies at z {approx}> 1 and speculate on possible evolution in the relationship between black hole accretion and the host galaxy toward high redshifts.

  9. Acute and fractionated exposure to high-LET (56)Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis.

    PubMed

    Rivera, Phillip D; Shih, Hung-Ying; Leblanc, Junie A; Cole, Mara G; Amaral, Wellington Z; Mukherjee, Shibani; Zhang, Shichuan; Lucero, Melanie J; Decarolis, Nathan A; Chen, Benjamin P C; Eisch, Amelia J

    2013-12-01

    Astronauts on multi-year interplanetary missions will be exposed to a low, chronic dose of high-energy, high-charge particles. Studies in rodents show acute, nonfractionated exposure to these particles causes brain changes such as fewer adult-generated hippocampal neurons and stem cells that may be detrimental to cognition and mood regulation and thus compromise mission success. However, the influence of a low, chronic dose of these particles on neurogenesis and stem cells is unknown. To examine the influence of galactic cosmic radiation on neurogenesis, adult-generated stem and progenitor cells in Nestin-CreER(T2)/R26R-YFP transgenic mice were inducibly labeled to allow fate tracking. Mice were then sham exposed or given one acute 100 cGy (56)Fe-particle exposure or five fractionated 20 cGy (56)Fe-particle exposures. Adult-generated hippocampal neurons and stem cells were quantified 24 h or 3 months later. Both acute and fractionated exposure decreased the amount of proliferating cells and immature neurons relative to sham exposure. Unexpectedly, neither acute nor fractionated exposure decreased the number of adult neural stem cells relative to sham expsoure. Our findings show that single and fractionated exposures of (56)Fe-particle irradiation are similarly detrimental to adult-generated neurons. Implications for future missions and ground-based studies in space radiation are discussed. PMID:24320054

  10. Acute and Fractionated Exposure to High-LET 56Fe HZE-Particle Radiation Both Result in Similar Long-Term Deficits in Adult Hippocampal Neurogenesis

    PubMed Central

    Rivera, Phillip D.; Shih, Hung-Ying; LeBlanc, Junie A.; Cole, Mara G.; Amaral, Wellington Z.; Mukherjee, Shibani; Zhang, Shichuan; Lucero, Melanie J.; DeCarolis, Nathan A.; Chen, Benjamin P. C.; Eisch, Amelia J.

    2014-01-01

    Astronauts on multi-year interplanetary missions will be exposed to a low, chronic dose of high-energy, high-charge particles. Studies in rodents show acute, nonfractionated exposure to these particles causes brain changes such as fewer adult-generated hippocampal neurons and stem cells that may be detrimental to cognition and mood regulation and thus compromise mission success. However, the influence of a low, chronic dose of these particles on neurogenesis and stem cells is unknown. To examine the influence of galactic cosmic radiation on neurogenesis, adult-generated stem and progenitor cells in Nestin-CreERT2/R26R-YFP transgenic mice were inducibly labeled to allow fate tracking. Mice were then sham exposed or given one acute 100 cGy 56Fe-particle exposure or five fractionated 20 cGy 56Fe-particle exposures. Adult-generated hippocampal neurons and stem cells were quantified 24 h or 3 months later. Both acute and fractionated exposure decreased the amount of proliferating cells and immature neurons relative to sham exposure. Unexpectedly, neither acute nor fractionated exposure decreased the number of adult neural stem cells relative to sham expsoure. Our findings show that single and fractionated exposures of 56Fe-particle irradiation are similarly detrimental to adult-generated neurons. Implications for future missions and ground-based studies in space radiation are discussed. PMID:24320054

  11. Marking Student Programs Using Graph Similarity

    ERIC Educational Resources Information Center

    Naude, Kevin A.; Greyling, Jean H.; Vogts, Dieter

    2010-01-01

    We present a novel approach to the automated marking of student programming assignments. Our technique quantifies the structural similarity between unmarked student submissions and marked solutions, and is the basis by which we assign marks. This is accomplished through an efficient novel graph similarity measure ("AssignSim"). Our experiments…

  12. Exposure of first-feeding cod larvae to dispersed crude oil results in similar transcriptional and metabolic responses as food deprivation.

    PubMed

    Hansen, Bjørn Henrik; Lie, Kai K; Størseth, Trond R; Nordtug, Trond; Altin, Dag; Olsvik, Pål A

    2016-01-01

    Exposure of first-feeding cod larvae (Gadus morhua) to dispersed oil results in reduced feeding during an important transition period. First-feeding cod larvae were subjected to a 4-d treatment of food deprivation and sampled for microarray analyses. These microarray data were combined with data from cod larvae treated with mechanically and chemically dispersed oil in an attempt to understand to what extent starvation might explain some of the effects observed in first-feeding cod larvae during oil exposure. Transcriptional profiling of cod larvae suggested that the influence of oil exposure was almost as dramatic as being completely deprived of food. Protein and cellular degradation and loss of amino acids and glucose appear to be concomitant responses to both oil exposure and starvation. Fluorescence imaging of gut content indicated low uptake of food, and reduced growth (decrease in dry weight and in carbon and nitrogen content) was also noted in oil-exposed larvae, providing phenotypic anchoring of microarray data. The study displays the importance in combining use of high-throughput molecular tools with assessment of fitness-related endpoints in order to provide a greater understanding of toxicant-induced responses. This combined-approach investigation suggests that reduction of food uptake is an important process to be included when predicting effects of accidental oil spills. Finally, when comparing data from two oil treatments, exposure to chemically dispersed oil did not appear to result in greater toxicity than exposure to mechanically dispersed oil.

  13. Exposure of first-feeding cod larvae to dispersed crude oil results in similar transcriptional and metabolic responses as food deprivation.

    PubMed

    Hansen, Bjørn Henrik; Lie, Kai K; Størseth, Trond R; Nordtug, Trond; Altin, Dag; Olsvik, Pål A

    2016-01-01

    Exposure of first-feeding cod larvae (Gadus morhua) to dispersed oil results in reduced feeding during an important transition period. First-feeding cod larvae were subjected to a 4-d treatment of food deprivation and sampled for microarray analyses. These microarray data were combined with data from cod larvae treated with mechanically and chemically dispersed oil in an attempt to understand to what extent starvation might explain some of the effects observed in first-feeding cod larvae during oil exposure. Transcriptional profiling of cod larvae suggested that the influence of oil exposure was almost as dramatic as being completely deprived of food. Protein and cellular degradation and loss of amino acids and glucose appear to be concomitant responses to both oil exposure and starvation. Fluorescence imaging of gut content indicated low uptake of food, and reduced growth (decrease in dry weight and in carbon and nitrogen content) was also noted in oil-exposed larvae, providing phenotypic anchoring of microarray data. The study displays the importance in combining use of high-throughput molecular tools with assessment of fitness-related endpoints in order to provide a greater understanding of toxicant-induced responses. This combined-approach investigation suggests that reduction of food uptake is an important process to be included when predicting effects of accidental oil spills. Finally, when comparing data from two oil treatments, exposure to chemically dispersed oil did not appear to result in greater toxicity than exposure to mechanically dispersed oil. PMID:27484138

  14. Structures and Dynamics Division research and technology plans for FY 1894 and accomplishments for FY 1982

    NASA Technical Reports Server (NTRS)

    Bales, K. S.

    1984-01-01

    The Objectives, Expected Results, Approach, and Fiscal Year FY 1984 Milestones for the Structures and Dynamics Division's research programs are examined. The FY 1983 Accomplishments are presented where applicable.

  15. E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke.

    PubMed

    Martin, Elizabeth M; Clapp, Phillip W; Rebuli, Meghan E; Pawlak, Erica A; Glista-Baker, Ellen; Benowitz, Neal L; Fry, Rebecca C; Jaspers, Ilona

    2016-07-01

    Exposure to cigarette smoke is known to result in impaired host defense responses and immune suppressive effects. However, the effects of new and emerging tobacco products, such as e-cigarettes, on the immune status of the respiratory epithelium are largely unknown. We conducted a clinical study collecting superficial nasal scrape biopsies, nasal lavage, urine, and serum from nonsmokers, cigarette smokers, and e-cigarette users and assessed them for changes in immune gene expression profiles. Smoking status was determined based on a smoking history and a 3- to 4-wk smoking diary and confirmed using serum cotinine and urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels. Total RNA from nasal scrape biopsies was analyzed using the nCounter Human Immunology v2 Expression panel. Smoking cigarettes or vaping e-cigarettes resulted in decreased expression of immune-related genes. All genes with decreased expression in cigarette smokers (n = 53) were also decreased in e-cigarette smokers. Additionally, vaping e-cigarettes was associated with suppression of a large number of unique genes (n = 305). Furthermore, the e-cigarette users showed a greater suppression of genes common with those changed in cigarette smokers. This was particularly apparent for suppressed expression of transcription factors, such as EGR1, which was functionally associated with decreased expression of 5 target genes in cigarette smokers and 18 target genes in e-cigarette users. Taken together, these data indicate that vaping e-cigarettes is associated with decreased expression of a large number of immune-related genes, which are consistent with immune suppression at the level of the nasal mucosa.

  16. The gender similarities hypothesis.

    PubMed

    Hyde, Janet Shibley

    2005-09-01

    The differences model, which argues that males and females are vastly different psychologically, dominates the popular media. Here, the author advances a very different view, the gender similarities hypothesis, which holds that males and females are similar on most, but not all, psychological variables. Results from a review of 46 meta-analyses support the gender similarities hypothesis. Gender differences can vary substantially in magnitude at different ages and depend on the context in which measurement occurs. Overinflated claims of gender differences carry substantial costs in areas such as the workplace and relationships. PMID:16173891

  17. The gender similarities hypothesis.

    PubMed

    Hyde, Janet Shibley

    2005-09-01

    The differences model, which argues that males and females are vastly different psychologically, dominates the popular media. Here, the author advances a very different view, the gender similarities hypothesis, which holds that males and females are similar on most, but not all, psychological variables. Results from a review of 46 meta-analyses support the gender similarities hypothesis. Gender differences can vary substantially in magnitude at different ages and depend on the context in which measurement occurs. Overinflated claims of gender differences carry substantial costs in areas such as the workplace and relationships.

  18. Recent NASA research accomplishments aboard the ISS.

    PubMed

    Pellis, Neal R; North, Regina M

    2004-01-01

    The activation of the US Laboratory Module "Destiny" on the International Space Station (ISS) in February 2001 launched a new era in microgravity research. Destiny provides the environment to conduct long-term microgravity research utilizing human intervention to assess, report, and modify experiments real time. As the only available pressurized space platform, ISS maximizes today's scientific resources and substantially increases the opportunity to obtain much longed-for answers on the effects of microgravity and long-term exposure to space. In addition, it evokes unexpected questions and results while experiments are still being conducted, affording time for changes and further investigation. While building and outfitting the ISS is the main priority during the current ISS assembly phase, seven different space station crews have already spent more than 2000 crew hours on approximately 80 scientific investigations, technology development activities, and educational demonstrations.

  19. Glacier Monitoring: Opportunities, Accomplishments, and Limitations.

    NASA Astrophysics Data System (ADS)

    Meier, M. F.; Dyurgerov, M. B.

    2001-12-01

    Glaciers and ice caps, exclusive of the two major ice sheets, have been monitored for more than a century. Initially sparked by interest in the effect of glaciers on the landscape and their sensitive response to changes of climate, glacier study is now additionally motivated because of impacts on cold-regions ecology and hydrology as well as global sea-level rise. Glacier observations in many areas provide the only real data on climate change in the mountains. A substantial number of mass balance programs were initiated during the 1960s that improved our understanding of spatial and temporal changes in climate, and provided a basis for projecting future changes to glaciers and sea level. These results show a general increase in both snow accumulation and ice melting during the last 40 years (but with net wastage predominating), and a marked increase in the sensitivity of ice wastage to air temperature since the late 1980s. The World Data Center system provided unrestricted exchange of data among glaciologists during the `cold war.' The World Glacier Monitoring Service together with the National Snow and Ice Data Center and several individuals now provide ready access to glacier data. Remaining problems include inadequate access to digital data, a size bias to small glaciers, some traditional methodologies which limit the usefulness of the results, slow incorporation of new technologies, complexity of incorporating glacier dynamics in mass balance analysis, and insufficient attention by some investigators to reporting observational error. Perhaps the most difficult problems are the extension of limited data to the synthesis of broad regional or global conclusions, and a general dwindling of support for monitoring activities.

  20. Silencing of a metaphase I-specific gene results in a phenotype similar to that of the Pairing homeologous 1 (Ph1) gene mutations.

    PubMed

    Bhullar, Ramanjot; Nagarajan, Ragupathi; Bennypaul, Harvinder; Sidhu, Gaganpreet K; Sidhu, Gaganjot; Rustgi, Sachin; von Wettstein, Diter; Gill, Kulvinder S

    2014-09-30

    Although studied extensively since 1958, the molecular mode of action of the Pairing homeologous 1 (Ph1) gene is still unknown. In polyploid wheat, the diploid-like chromosome pairing is principally controlled by the Ph1 gene via preventing homeologous chromosome pairing (HECP). Here, we report a candidate Ph1 gene (C-Ph1) present in the Ph1 locus, transient as well as stable silencing of which resulted in a phenotype characteristic of the Ph1 gene mutants, including HECP, multivalent formation, and disrupted chromosome alignment on the metaphase I (MI) plate. Despite a highly conserved DNA sequence, the C-Ph1 gene homeologues showed a dramatically different structure and expression pattern, with only the 5B copy showing MI-specific expression, further supporting our claim for the Ph1 gene. In agreement with the previous reports about the Ph1 gene, the predicted protein of the 5A copy of the C-Ph1 gene is truncated, and thus perhaps less effective. The 5D copy is expressed around the onset of meiosis; thus, it may function during the earlier stages of chromosome pairing. Along with alternate splicing, the predicted protein of the 5B copy is different from the protein of the other two copies because of an insertion. These structural and expression differences among the homeologues concurred with the previous observations about Ph1 gene function. Stable RNAi silencing of the wheat gene in Arabidopsis showed multivalents and centromere clustering during meiosis I. PMID:25232038

  1. Lunabotics Mining Competition: Inspiration through Accomplishment

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.

    2012-01-01

    Space Mining for resources such as water ice, and regolith, which contain many elements in the form of metals, minerals, volatiles and other compounds, is a necessary step in Space Resource Utilization. One of the primary goals is to extract propellants from the regolith such as oxygen and hydrogen which could then be used for in-space transportation. In addition, the space mining system can be used for various construction tasks that can benefit human and robotic exploration as well as scientific investigations based on the exposed topography. The National Aeronautics & Space Administration (NASA) Lunabotics Mining Competition is a university-level competition designed to engage and retain students in science, technology, engineering and mathematics (STEM). NASA will directly benefit from the competition by encouraging the development of innovative lunar excavation concepts from universities which may result in clever ideas and solutions which could be applied to an actual lunar excavation device or payload. The challenge is for students to design and build a remote controlled or autonomous excavator, called a lunabot, that can collect and deposit a minimum of 10 kilograms of lunar simulant within 15 minutes. The complexities of the challenge include the abrasive characteristics of the lunar simulant, the weight and size limitations of the lunabot, and the ability to control the lunabot from a remote control center or operate autonomously. This paper will present an update of the results and lessons learned during the first and second annual Lunabotics Mining Competitions held in May 2010 and May 2011. It will also preview the 2012 competition with a review of the revised rules. In 2010,22 United States (US) universities competed, and in May 2011 the competition was opened to international participation. In 2011, 36 teams actually competed from 26 USA states and 4 foreign countries (India, Bangladesh, Colombia and Canada). This combined total directly inspired an

  2. Overview and accomplishments of the Borexino experiment

    NASA Astrophysics Data System (ADS)

    Ranucci, G.; Agostini, M.; Appel, S.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Chepurnov, A.; D'Angelo, D.; Davini, S.; Derbin, A.; Di Noto, L.; Drachnev, I.; Etenko, A.; Fomenko, K.; Franco, D.; Gabriele, F.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Goeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jedrzejczak, K.; Kaiser, M.; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lehnert, B.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Neumair, B.; Oberauer, L.; Obolensky, M.; Ortica, F.; Pallavicini, M.; Papp, L.; Perasso, L.; Pocar, A.; Razeto, A.; Re, A.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Semenov, D.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Vishneva, A.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

    2016-02-01

    The Borexino experiment is running at the Laboratori del Gran Sasso in Italy since 2007. Its technical distinctive feature is the unprecedented ultralow background of the inner scintillating core, which is the basis of the outstanding achievements accumulated by the experiment. In this talk, after recalling the main features of the detector, the impressive solar data gathered so far by the experiment will be summarized, with special emphasis to the most recent and prominent result concerning the detection of the fundamental pp solar neutrino flux, which is the direct probe of the engine mechanism powering our star. Such a milestone measurement puts Borexino in the unique situation of being the only experiment able to do solar neutrino spectroscopy over the entire solar spectrum; the counterpart of this peculiar status in the oscillation interpretation of the data is the capability of Borexino alone to perform the full validation across the solar energy range of the MSW-LMA paradigm. The talk will be concluded highlighting the perspectives for the final stage of the solar program of the experiment, centered on the goal to fully complete the solar spectroscopy with the missing piece of the CNO neutrinos. If successful, such a measurement would represent the final crowning of the long quest of Borexino to unravel all the properties of the neutrinos from the Sun.

  3. Research Progress and Accomplishments on ISS

    NASA Technical Reports Server (NTRS)

    Roe, Lesa B.; Uri, John J.

    2002-01-01

    The first research payloads reached the International Space Station (ISS) more than two years ago, with research operating continuously since March 2001. Seven research racks are currently on-orbit, with three more arriving soon to expand science capabilities. Through the first five expeditions, 60 unique NASA-managed investigations from 11 nations have been supported, many continuing into later missions. More than 90,000 experiment hours have been completed, and more than 1,000 hours of crew time have been dedicated to research, numbers that grow daily. The multidisciplinary program includes research in life sciences, physical sciences, biotechnology, Earth sciences, technology demonstrations as well as commercial endeavors and educational activities. The Payload Operations and Integration Center monitors the onboard activities around the clock, working with numerous Principal Investigators and Payload Developers at their remote sites. Future years will see expansion of the station with research modules provided by the European Space Agency and Japan, which will be outfitted with additional research racks. The first research payloads arrived at ISS more than two years ago, and continuous science has been ongoing for more than one and a half years. During this time, the research capabilities have been tremendously increased, even as assembly of the overall platform continues. Despite significant challenges along the way, ISS continues to successfully support a large number of investigations in a variety of research disciplines. The results of some of the early investigations are reaching the publication stage. The near future looms with new challenges, but experience to date and dedicated efforts give reason to be optimistic that the challenges will be overcome and that new and greater successes will be added to past ones.

  4. OTEC mooring system development: recent accomplishments. Technical report

    SciTech Connect

    Ross, J.M.; Wood, W.A.

    1981-10-01

    The mooring system for a floating OTEC platform consists of a seafloor foundation, a platform foundation, and a connecting line. This paper introduces the OTEC mooring system with a brief historical overview, reviews developmental work accomplished during the past year, and then presents a new look at life cycle costs for an example mooring system. Since June 1980, a significant effort within the OTEC Program has been directed toward the further development of mooring systems. The effort has included work leading to a better understanding of anchoring capabilities and problems, refinement of an existing mooring analytical model, a review of OTEC past mooring designs, and the production of a mooring system technology development plan. A major finding of the past year was a new upward estimate of mooring system lifetime costs as a result of downward-revised estimates of wire rope service life.

  5. Space directorate research and technology accomplishments for FY 1988

    NASA Technical Reports Server (NTRS)

    Avery, Don E. (Compiler)

    1989-01-01

    The major accomplishments and test highlights for FY 1988 that occurred in the Space Dirctorate are given. Accomplishments and test highlights are presented by Division and Branch. The presented information will be useful in program coordination with government organizations, universities, and industry in areas of mutual interest.

  6. Use of Information Systems to Acknowledge Instructional Accomplishments of Schools.

    ERIC Educational Resources Information Center

    Moncrief, Michael H.

    This paper describes the components of an Instructional Accomplishment Information (IAI) system, discusses general procedures for using the information reports to communicate instructional accomplishments to appropriate audiences, compares IAI information and standardized tests in a public relations context, and notes the role of educational…

  7. Space directorate research and technology accomplishments for fiscal year 1987

    NASA Technical Reports Server (NTRS)

    Avery, Don E.

    1988-01-01

    The major accomplishments and test highlights of the Space Directorate of NASA Langley Research Center for FY87 are presented. Accomplishments and test highlights are listed by Division and Branch. This information should be useful in coordinating programs with government organizations, universities, and industry in areas of mutual interest.

  8. The relations of daily task accomplishment satisfaction with changes in affect: a multilevel study in nurses.

    PubMed

    Gabriel, Allison S; Diefendorff, James M; Erickson, Rebecca J

    2011-09-01

    Focusing on a sample of nurses, this investigation examined the relationships of daily task accomplishment satisfaction (for direct and indirect care tasks) with changes in positive and negative affect from preshift to postshift. Not accomplishing tasks to one's satisfaction was conceptualized as a daily workplace stressor that should increase daily negative affect and decrease daily positive affect from preshift to postshift. Further, because of the greater centrality of direct care nursing tasks to nursing work role identities (relative to indirect care tasks), we expected that task accomplishment satisfaction (or lack thereof) for these tasks would have stronger effects on changes in affect than would task accomplishment satisfaction for indirect care tasks. We also examined 2 person-level resources, collegial nurse-physician relations and psychological resilience, as moderators of the relationships among these daily variables, with the expectation that these resources would buffer the harmful effects of low task accomplishment satisfaction on nurse affect. Results supported almost all of the proposed effects, though the cross-level interactions were observed only for the effects of indirect care task accomplishment satisfaction on affect and not for direct care task accomplishment satisfaction on affect. PMID:21639600

  9. Marine hydrogeology: recent accomplishments and future opportunities

    NASA Astrophysics Data System (ADS)

    Fisher, A. T.

    2005-03-01

    Marine hydrogeology is a broad-ranging scientific discipline involving the exploration of fluid-rock interactions below the seafloor. Studies have been conducted at seafloor spreading centers, mid-plate locations, and in plate- and continental-margin environments. Although many seafloor locations are remote, there are aspects of marine systems that make them uniquely suited for hydrologic analysis. Newly developed tools and techniques, and the establishment of several multidisciplinary programs for oceanographic exploration, have helped to push marine hydrogeology forward over the last several decades. Most marine hydrogeologic work has focused on measurement or estimation of hydrogeologic properties within the shallow subsurface, but additional work has emphasized measurements of local and global fluxes, fluid source and sink terms, and quantitative links between hydrogeologic, chemical, tectonic, biological, and geophysical processes. In addition to summarizing selected results from a small number of case studies, this paper includes a description of several new experiments and programs that will provide outstanding opportunities to address fundamental hydrogeologic questions within the seafloor during the next 20-30 years. L'hydrogéologie marine est une large discipline scientifique impliquant l' exploration des interactions entre les fluides et les roches sous les fonds marins. Des études ont été menées dans les différents environnements sous-marins (zone abyssale, plaque océanique, marges continentales). Bien que de nombreux fonds marins soient connus, il existe des aspects des systèmes marins qui les rendent inadaptés à l'analyse hydrologique. De nouveaux outils et techniques, et la mise en oeuvre de nombreux programmes multidisciplinaires d'exploration océanographique, ont aidé à pousser en avant l'hydrogéologie marine ces dix dernières années. La plus part des études hydrogéologiques se sont concentrées jusqu'à présent sur la mesure ou

  10. IMHEX fuel cell repeat component manufacturing continuous improvement accomplishments

    SciTech Connect

    Jakaitis, L.A.; Petraglia, V.J.; Bryson, E.S.

    1996-12-31

    M-C Power is taking a power generation technology that has been proven in the laboratory and is making it a commercially competitive product. There are many areas in which this technology required scale up and refinement to reach the market entry goals for the IMHEX{reg_sign} molten carbonate fuel cell power plant. One of the primary areas that needed to be addressed was the manufacturing of the fuel cell stack. Up to this point, the fuel cell stack and associated components were virtually hand made for each system to be tested. M-C Power has now continuously manufactured the repeat components for three 250 kW stacks. M-C Power`s manufacturing strategy integrated both evolutionary and revolutionary improvements into its comprehensive commercialization effort. M-C Power`s objectives were to analyze and continuously improve stack component manufacturing and assembly techniques consistent with established specifications and commercial scale production requirements. Evolutionary improvements are those which naturally occur as the production rates are increased and experience is gained. Examples of evolutionary (learning curve) improvements included reducing scrap rates and decreasing raw material costs by buying in large quantities. Revolutionary improvements result in significant design and process changes to meet cost and performance requirements of the market entry system. Revolutionary changes often involve identifying new methods and developing designs to accommodate the new process. Based upon our accomplishments, M-C Power was able to reduce the cost of continuously manufactured fuel cell repeat components from the first to third 250 kW stack by 63%. This paper documents the continuous improvement accomplishments realized by M-C Power during IMHEX{reg_sign} fuel cell repeat component manufacturing.

  11. Multivariate Hypergeometric Similarity Measure

    PubMed Central

    Kaddi, Chanchala D.; Parry, R. Mitchell; Wang, May D.

    2016-01-01

    We propose a similarity measure based on the multivariate hypergeometric distribution for the pairwise comparison of images and data vectors. The formulation and performance of the proposed measure are compared with other similarity measures using synthetic data. A method of piecewise approximation is also implemented to facilitate application of the proposed measure to large samples. Example applications of the proposed similarity measure are presented using mass spectrometry imaging data and gene expression microarray data. Results from synthetic and biological data indicate that the proposed measure is capable of providing meaningful discrimination between samples, and that it can be a useful tool for identifying potentially related samples in large-scale biological data sets. PMID:24407308

  12. Enhanced surveillance program FY97 accomplishments. Progress report

    SciTech Connect

    Mauzy, A.; Laake, B.

    1997-10-01

    This annual report is one volume of the Enhanced Surveillance Program (ESP) FY97 Accomplishments. The complete accomplishments report consists of 11 volumes. Volume 1 includes an ESP overview and a summary of selected unclassified FY97 program highlights. Volume 1 specifically targets a general audience, reflecting about half of the tasks conducted in FY97 and emphasizing key program accomplishments and contributions. The remaining volumes of the accomplishments report are classified, organized by program focus area, and present in technical detail the progress achieved in each of the 104 FY97 program tasks. Focus areas are as follows: pits; high explosives; organics; dynamics; diagnostics; systems; secondaries; nonnuclear materials; nonnuclear components; and Surveillance Test Program upgrades.

  13. Idaho National Laboratory Mission Accomplishments, Fiscal Year 2015

    SciTech Connect

    Allen, Todd Randall; Wright, Virginia Latta

    2015-09-01

    A summary of mission accomplishments for the research organizations at the Idaho National Laboratory for FY 2015. Areas include Nuclear Energy, National and Homeland Security, Science and Technology Addressing Broad DOE Missions; Collaborations; and Stewardship and Operation of Research Facilities.

  14. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  15. National Climate Change and Wildlife Science Center project accomplishments: highlights

    USGS Publications Warehouse

    Holl, Sally

    2011-01-01

    The National Climate Change and Wildlife Science Center (NCCWSC) has invested more than $20M since 2008 to put cutting-edge climate science research in the hands of resource managers across the Nation. With NCCWSC support, more than 25 cooperative research initiatives led by U.S. Geological Survey (USGS) researchers and technical staff are advancing our understanding of habitats and species to provide guidance to managers in the face of a changing climate. Projects focus on quantifying and predicting interactions between climate, habitats, species, and other natural resources such as water. Spatial scales of the projects range from the continent of North America, to a regional scale such as the Pacific Northwest United States, to a landscape scale such as the Florida Everglades. Time scales range from the outset of the 20th century to the end of the 21st century. Projects often lead to workshops, presentations, publications and the creation of new websites, computer models, and data visualization tools. Partnership-building is also a key focus of the NCCWSC-supported projects. New and on-going cooperative partnerships have been forged and strengthened with resource managers and scientists at Federal, tribal, state, local, academic, and non-governmental organizations. USGS scientists work closely with resource managers to produce timely and relevant results that can assist managers and policy makers in current resource management decisions. This fact sheet highlights accomplishments of five NCCWSC projects.

  16. The Mixed Waste Focus Area: Status and accomplishments

    SciTech Connect

    Conner, J.E.; Williams, R.E.

    1997-08-01

    The Mixed Waste Focus Area began operations in February of 1995. Its mission is to provide acceptable technologies that enable implementation of mixed waste treatment systems developed in partnership with end-users, stakeholders, tribal governments, and regulators. The MWFA will develop, demonstrate, and deliver implementable technologies for treatment of mixed waste within the DOE complex. Treatment refers to all post waste-generation activities including sampling and analysis, characterization, storage, processing, packaging, transportation, and disposal. The MWFA`s mission arises from the Resources Conservation and Recovery Act (RCRA) as amended by the Federal Facility Compliance Act. Each DOE site facility that generates or stores mixed waste prepared a plan, the Site Treatment Plan, for developing treatment capacities and treating that waste. Agreements for each site were concluded with state regulators, resulting in Consent Orders providing enforceable milestones for achieving treatment of the waste. The paper discusses the implementation of the program, its status, accomplishments and goals for FY1996, and plans for 1997.

  17. Semantically enabled image similarity search

    NASA Astrophysics Data System (ADS)

    Casterline, May V.; Emerick, Timothy; Sadeghi, Kolia; Gosse, C. A.; Bartlett, Brent; Casey, Jason

    2015-05-01

    Georeferenced data of various modalities are increasingly available for intelligence and commercial use, however effectively exploiting these sources demands a unified data space capable of capturing the unique contribution of each input. This work presents a suite of software tools for representing geospatial vector data and overhead imagery in a shared high-dimension vector or embedding" space that supports fused learning and similarity search across dissimilar modalities. While the approach is suitable for fusing arbitrary input types, including free text, the present work exploits the obvious but computationally difficult relationship between GIS and overhead imagery. GIS is comprised of temporally-smoothed but information-limited content of a GIS, while overhead imagery provides an information-rich but temporally-limited perspective. This processing framework includes some important extensions of concepts in literature but, more critically, presents a means to accomplish them as a unified framework at scale on commodity cloud architectures.

  18. The 1987-1988 NASA space/gravitational biology accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1988-01-01

    Individual technical summaries of research projects of the NASA Space/Gravitational Biology Program, for research conducted during the period January 1987 to April 1988 are presented. This Program is concerned with using the characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  19. The 1985-86 NASA space/gravitational biology accomplishments

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Individual Technical summaries of research projects of NASA's Space/Gravitational Biology Program are presented. This Program is concerned with using the unique characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on Earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a listing of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  20. The 1986-87 NASA space/gravitational biology accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1987-01-01

    This report consists of individual technical summaries of research projects of NASA's Space/Gravitational Biology program, for research conducted during the period January 1986 to April 1987. This program utilizes the unique characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on Earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a list of accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  1. The 1989-1990 NASA space biology accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1991-01-01

    Individual technical summaries of research projects on NASA's Space Biology Program for research conducted during the period May 1989 to April 1990 are presented. This program is concerned with using the unique characteristics of the space environment, particularly microgravity, as a tool to advance the following: (1) knowledge in the biological sciences; (2) understanding of how gravity has shaped and affected life on the Earth; and (3) understanding of how the space environment affects both plants and animals. The summaries for each project include a description of the research, a list of accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  2. The 1988-1989 NASA Space/Gravitational Biology Accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1990-01-01

    This report consists of individual technical summaries of research projects of NASA's space/gravitational biology program, for research conducted during the period May 1988 to April 1989. This program is concerned with using the unique characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on Earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  3. Functional Similarity and Interpersonal Attraction.

    ERIC Educational Resources Information Center

    Neimeyer, Greg J.; Neimeyer, Robert A.

    1981-01-01

    Students participated in dyadic disclosure exercises over a five-week period. Results indicated members of high functional similarity dyads evidenced greater attraction to one another than did members of low functional similarity dyads. "Friendship" pairs of male undergraduates displayed greater functional similarity than did "nominal" pairs from…

  4. Working Together: California Indians and the Forest Service. Accomplishment Report.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Berkeley, CA. Pacific Southwest Forest and Range Experiment Station.

    This report describes accomplishments of the Forest Services's Tribal Relations Program in California, highlighting coordinated efforts with tribal governments and Native American communities throughout California's national forests. The regional office provided intensive training on federal-tribal relations to key staff throughout the region, and…

  5. Final report on technical work accomplished under contract NASw-2953

    NASA Technical Reports Server (NTRS)

    Fredricks, R. W.

    1977-01-01

    A report is given on the technical work accomplished in the area of plasma physics. The subjects covered are: (1) oblique whistler instabilities, (2) current-limited electron beam injection, (3) three-dimensional ion sound turbulence, (4) theoretical aspects of sounder antenna operation and (5) whistler modes in bow shock structures.

  6. Women in History--Abigail Adams: Life, Accomplishments, and Ideas

    ERIC Educational Resources Information Center

    Kenan, Sharon K.

    2008-01-01

    This article profiles the life, accomplishments, and ideas of Abigail Adams. Born in 1944, Adams lacked a formal education, but she more than made up for that shortcoming with her love of reading, especially literature, and her interests in politics and events surrounding the young colonies. Adams was supportive of the advancement of women. She…

  7. 38 CFR 39.120 - Documentation of grant accomplishments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Documentation of grant accomplishments. 39.120 Section 39.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF...

  8. 38 CFR 39.120 - Documentation of grant accomplishments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Documentation of grant accomplishments. 39.120 Section 39.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF...

  9. 38 CFR 39.120 - Documentation of grant accomplishments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Documentation of grant accomplishments. 39.120 Section 39.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID TO STATES FOR ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE,...

  10. 38 CFR 39.120 - Documentation of grant accomplishments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Documentation of grant accomplishments. 39.120 Section 39.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF...

  11. Do Laboratory Results Concerning High-Viscosity Glass-Ionomers versus Amalgam for Tooth Restorations Indicate Similar Effect Direction and Magnitude than that of Controlled Clinical Trials? - A Meta-Epidemiological Study

    PubMed Central

    Mickenautsch, Steffen; Yengopal, Veerasamy

    2015-01-01

    Background A large percentage of evidence concerning dental interventions is based on laboratory research. The apparent wealth of laboratory evidence is sometimes used as basis for clinical inference and recommendations for daily dental practice. In this study two null-hypotheses are tested: whether trial results from laboratory and controlled clinical trials concerning the comparison of high-viscosity glass-ionomer cements (HVGIC) to amalgam for restorations placed in permanent posterior teeth have: (i) similar effect direction and (ii) similar effect magnitude. Methods 7 electronic databases were searched, as well as reference lists. Odds ratios (OR) and Standardised Mean Differences (SMD) with 95% Confidence intervals were computed for extracted dichotomous and continuous data, respectively. Pooled effect estimates for laboratory and clinical data were computed to test for effect direction. Odds ratios were converted into SMDs. SMDs from laboratory and clinical data were statistically compared to test for differences in effect magnitude. The analysed results were further investigated within the context of potential influencing or confounding factors using a Directed acyclic graph. Results Of the accepted eight laboratory and nine clinical trials, 13 and 21 datasets could be extracted, respectively. The pooled results of the laboratory datasets were highly statistically significant in favor of amalgam. No statistically significant differences, between HVGICs and amalgam, were identified for clinical data. For effect magnitude, statistically significant differences between clinical and laboratory trial results were found. Both null-hypotheses were rejected. Conclusion Laboratory results concerning high-viscosity glass-ionomers versus amalgam for tooth restorations do not indicate similar effect direction and magnitude than that of controlled clinical trials. PMID:26168274

  12. FY 1995 research highlights: PNL accomplishments in OER programs

    SciTech Connect

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  13. The 1992-1993 NASA Space Biology Accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1994-01-01

    This report consists of individual technical summaries of research projects of NASA's Space Biology Program, for research conducted during the calendar years of 1992 and 1993. This program includes both plant and animal research, and is dedicated to understanding the role of gravity and the effects of microgravity on biological processes; determining the effects of the interaction of gravity and other environmental factors on biological systems; and using the microgravity of the space environment as a tool to advance fundamental scientific knowledge in the biological sciences to improve the quality of life on Earth and contribute to NASA's goal of manned exploration of space. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  14. The 1990-1991 NASA space biology accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, Thora W. (Editor)

    1993-01-01

    This report consists of individual technical summaries of research projects of NASA's Space Biology Program, for research conducted during the period May 1990 through May 1991. This program includes both plant and animal research, and is dedicated to understanding the role of gravity and other environmental factors on biological systems and to using the microgravity of the space environment as a tool to advance fundamental scientific knowledge in the biological sciences to improve the quality of life on Earth and contribute to NASA's goal of manned exploration of space. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

  15. Abstract and research accomplishments of University Coal Research Projects

    SciTech Connect

    1995-06-01

    The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their respective projects in time for distribution at a conference on June 13--14, 1995 at Tennessee State University in Nashville, Tennessee. This book is a compilation of the material received in response to that request. For convenience, the 70 grants reported in this book are stored into eight technical areas, Coal Science, Coal Surface Science, Reaction Chemistry, Advanced Process Concepts, Engineering Fundamentals and Thermodynamics, Environmental Science, high Temperature Phenomena, and Special topics. Indexes are provided for locating projects by subject, principal investigators, and contracting organizations. Each extended abstract describes project objectives, work accomplished, significance to the Fossil Energy Program, and plans for the next year.

  16. Chemical Research Projects Office: Functions, accomplishments, and programs

    NASA Technical Reports Server (NTRS)

    Kourtides, D. A.; Parker, J. A.

    1972-01-01

    The purpose, technical accomplishments, and related activities of the Chemical Research Project Group are outlined. Data cover efforts made to: (1) identify chemical research and technology required for solutions to problems of national urgency, synchronous with aeronautics and space effort; (2) conduct basic and applied interdisciplinary research on chemical problems in the areas of macromolecular science and fire research, and (3) provide productive liason with the engineering community and effective transfer of technology to other agencies and industry.

  17. The eighth NASA total quality management accomplishments report, 1990

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The eighth annual accomplishments report provides numerous examples of quality strategies that have proven effective and efficient in a time when cost reduction is critical. NASA's continuous improvement efforts can provide insight for others to succeed in their own endeavors. The report covers: top management leadership and support, strategic planning, focus on the customer, employee training and recognition, employee empowerment and teamwork, measurement and analysis, and quality assurance.

  18. Abstracts and research accomplishments of university coal research projects

    SciTech Connect

    Not Available

    1991-06-01

    The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their projects in time for distribution at a grantees conference. This book is a compilation of the material received in response to the request. Abstracts discuss the following area: coal science, coal surface science, reaction chemistry, advanced process concepts, engineering fundamentals and thermodynamics, environmental science.

  19. NGNP Process Heat Applications: Hydrogen Production Accomplishments for FY2010

    SciTech Connect

    Charles V Park

    2011-01-01

    This report summarizes FY10 accomplishments of the Next Generation Nuclear Plant (NGNP) Engineering Process Heat Applications group in support of hydrogen production technology development. This organization is responsible for systems needed to transfer high temperature heat from a high temperature gas-cooled reactor (HTGR) reactor (being developed by the INL NGNP Project) to electric power generation and to potential industrial applications including the production of hydrogen.

  20. Fort Collins Science Center-Fiscal year 2011 science accomplishments

    USGS Publications Warehouse

    Wilson, Juliette T.

    2012-01-01

    The Fort Collins Science Center (FORT) is a multi-disciplinary research and development center of the U.S. Geological Survey located in Fort Collins, Colorado. FORT research focuses on the needs of land- and water-management bureaus within the U.S. Department of the Interior, other Federal agencies, and State, Tribal, and non-government organizations. We emphasize a multi-disciplinary science approach to provide information for natural resource management decisionmaking. Our vision is to maintain and continuously improve the integrated, collaborative, world-class research needed to inform effective, science-based land management. The 2011 science accomplishments report provides an executive summary highlighting key achievements, an appendix of 68 one-page accomplishment descriptions organized by U.S. Geological Survey Mission Area, and a complete list of publications and other products generated in FY2011. The executive summary includes a table cross-referencing all major FY11 accomplishments with the various Mission Areas each supports.

  1. Health and Environmental Research: Summary of Accomplishments. Volume 2

    DOE R&D Accomplishments Database

    1986-08-01

    This is an account of some of the accomplishments of the health and environmental research program performed in national laboratories, universities, and research institutes. Both direct and indirect societal benefits emerged from the new knowledge provided by the health and environmental research program. In many cases, the private sector took this knowledge and applied it well beyond the mission of supporting the defense and energy needs of the Nation. Industrial and medical applications, for example, have in several instances provided annual savings to society of $100 million or more. The form of this presentation is, in fact, through "snapshots" - examples of significant, tangible accomplishments in each of the areas at certain times to illustrate the role and impact of the research program. The program's worth is not necessarily confined to such accomplishments; it extends, rather, to its ability to identify and help solve potential health and environmental problems before they become critical. This anticipatory mission has been pursued with an approach that combines applied problem solving with a commitment to fundamental research that is long-term and high-risk. The narrative of this research program concludes with a perspective of its past and a prospectus on its future.

  2. When Lightning Strikes Twice: Profoundly Gifted, Profoundly Accomplished.

    PubMed

    Makel, Matthew C; Kell, Harrison J; Lubinski, David; Putallaz, Martha; Benbow, Camilla P

    2016-07-01

    The educational, occupational, and creative accomplishments of the profoundly gifted participants (IQs ⩾ 160) in the Study of Mathematically Precocious Youth (SMPY) are astounding, but are they representative of equally able 12-year-olds? Duke University's Talent Identification Program (TIP) identified 259 young adolescents who were equally gifted. By age 40, their life accomplishments also were extraordinary: Thirty-seven percent had earned doctorates, 7.5% had achieved academic tenure (4.3% at research-intensive universities), and 9% held patents; many were high-level leaders in major organizations. As was the case for the SMPY sample before them, differential ability strengths predicted their contrasting and eventual developmental trajectories-even though essentially all participants possessed both mathematical and verbal reasoning abilities far superior to those of typical Ph.D. recipients. Individuals, even profoundly gifted ones, primarily do what they are best at. Differences in ability patterns, like differences in interests, guide development along different paths, but ability level, coupled with commitment, determines whether and the extent to which noteworthy accomplishments are reached if opportunity presents itself. PMID:27225220

  3. Health and Environmental Research: summary of accomplishments. Volume 2

    SciTech Connect

    Not Available

    1986-08-01

    This is an account of some of the accomplishments of the health and environmental research program performed in national laboratories, universities, and research institutes. Both direct and indirect societal benefits emerged from the new knowledge provided by the health and environmental research program. In many cases, the private sector took this knowledge and applied it well beyond the mission of supporting the defense and energy needs of the Nation. Industrial and medical applications, for example, have in several instances provided annual savings to society of $100 million or more. The form of this presentation is, in fact, through ''snapshots'' - examples of significant, tangible accomplishments in each of the areas at certain times to illustrate the role and impact of the research program. The program's worth is not necessarily confined to such accomplishments; it extends, rather, to its ability to identify and help solve potential health and environmental problems before they become critical. This anticipatory mission has been pursued with an approach that combines applied problem solving with a commitment to fundamental research that is long-term and high-risk. The narrative of this research program concludes with a perspective of its past and a prospectus on its future.

  4. 2012 ACCOMPLISHMENTS - TRITIUM AGING STUDIES ON STAINLESS STEELS

    SciTech Connect

    Morgan, M.

    2013-01-31

    This report summarizes the research and development accomplishments during FY12 for the tritium effects on materials program. The tritium effects on materials program is designed to measure the long-term effects of tritium and its radioactive decay product, helium-3, on the structural properties of forged stainless steels which are used as the materials of construction for tritium reservoirs. The FY12 R&D accomplishments include: (1) Fabricated and Thermally-Charged 150 Forged Stainless Steel Samples with Tritium for Future Aging Studies; (2) Developed an Experimental Plan for Measuring Cracking Thresholds of Tritium-Charged-and-Aged Steels in High Pressure Hydrogen Gas; (3) Calculated Sample Tritium Contents For Laboratory Inventory Requirements and Environmental Release Estimates; (4) Published report on “Cracking Thresholds and Fracture Toughness Properties of Tritium-Charged-and-Aged Stainless Steels”; and, (5) Published report on “The Effects of Hydrogen, Tritium, and Heat Treatment on the Deformation and Fracture Toughness Properties of Stainless Steels”. These accomplishments are highlighted here and references given to additional reports for more detailed information.

  5. When Lightning Strikes Twice: Profoundly Gifted, Profoundly Accomplished.

    PubMed

    Makel, Matthew C; Kell, Harrison J; Lubinski, David; Putallaz, Martha; Benbow, Camilla P

    2016-07-01

    The educational, occupational, and creative accomplishments of the profoundly gifted participants (IQs ⩾ 160) in the Study of Mathematically Precocious Youth (SMPY) are astounding, but are they representative of equally able 12-year-olds? Duke University's Talent Identification Program (TIP) identified 259 young adolescents who were equally gifted. By age 40, their life accomplishments also were extraordinary: Thirty-seven percent had earned doctorates, 7.5% had achieved academic tenure (4.3% at research-intensive universities), and 9% held patents; many were high-level leaders in major organizations. As was the case for the SMPY sample before them, differential ability strengths predicted their contrasting and eventual developmental trajectories-even though essentially all participants possessed both mathematical and verbal reasoning abilities far superior to those of typical Ph.D. recipients. Individuals, even profoundly gifted ones, primarily do what they are best at. Differences in ability patterns, like differences in interests, guide development along different paths, but ability level, coupled with commitment, determines whether and the extent to which noteworthy accomplishments are reached if opportunity presents itself.

  6. Applied research and development private sector accomplishments. Final summary report

    SciTech Connect

    Beskid, N.J.; Devgun, J.S.; Zielke, M.M.; Erickson, M.D.

    1993-12-01

    Because of the nature of most US Department of Energy (DOE) operations, contamination at DOE sites presents complex problems. DOE sites may have radioactive, hazardous, or mixed contamination. The major contaminants include radionuclides, volatile organic compounds (VOCs), and heavy metals. The contamination exists in soils, groundwater, and buildings and materials. DOE`s special problems in site remediation have created a need for better and less costly technologies. Thus, DOE has implemented several initiatives for developing new technologies. This report describes the results of the first set of procurement contracts in this area. Similar research and development (R&D) activities are currently managed for DOE by the Morgantown Energy Technology Center.

  7. Biosimilar Insulins: How Similar is Similar?

    PubMed Central

    Heinemann, Lutz; Hompesch, Marcus

    2011-01-01

    Biosimilar insulins (BIs) are viewed as commercially attractive products by a number of companies. In order to obtain approval in the European Union or the United States, where there is not a single BI currently on the market, a manufacturer needs to demonstrate that a given BI has a safety and efficacy profile that is similar to that of the “original” insulin formulation that is already on the market. As trivial as this may appear at first glance, it is not trivial at all for a good number of reasons that will be discussed in this commentary. As with protein manufacturing, modifications in the structure of the insulin molecule can take place (which can have serious consequences for the biological effects induced), so a rigid and careful assessment is absolutely necessary. The example of Marvel's failed application with the European Medicines Agency provides insights into the regulatory and clinical challenges surrounding the matter of BI. Although a challenging BI approval process might be regarded as a hurdle to keep companies out of certain markets, it is fair to say that the potential safety and efficacy issues surrounding BI are substantial and relevant and do warrant a careful and evidence-driven approval process. PMID:21722590

  8. Significant effects due to rephrasing the Maslach Burnout Inventory's personal accomplishment items.

    PubMed

    Bouman, Anne Marthe; Te Brake, Hans; Hoogstraten, Johan

    2002-12-01

    Subjects, 292 Dutch psychology students answering negatively phrased Personal Accomplishment items, reported a more personally competent feeling than subjects answering positively phrased personal accomplishment items. The way of phrasing personal accomplishment items significantly affects the answers given.

  9. Space robotics: Recent accomplishments and opportunities for future research

    NASA Technical Reports Server (NTRS)

    Montgomery, Raymond C.; Buttrill, Carey S.; Dorsey, John T.; Juang, Jer-Nan; Lallman, Frederick J.; Moerder, Daniel D.; Scott, Michael A.; Troutman, Patrick; Williams, Robert L., II

    1992-01-01

    The Langley Guidance, Navigation, and Control Technical Committee (GNCTC) was one of six technical committees created in 1991 by the Chief Scientist, Dr. Michael F. Card. During the kickoff meeting Dr. Card charged the chairmen to: (1) establish a cross-Center committee; (2) support at least one workshop in a selected discipline; and (3) prepare a technical paper on recent accomplishments in the discipline and on opportunities for future research. The Guidance, Navigation, and Control Committee was formed and selected for focus on the discipline of Space robotics. This report is a summary of the committee's assessment of recent accomplishments and opportunities for future research. The report is organized as follows. First is an overview of the data sources used by the committee. Next is a description of technical needs identified by the committee followed by recent accomplishments. Opportunities for future research ends the main body of the report. It includes the primary recommendation of the committee that NASA establish a national space facility for the development of space automation and robotics, one element of which is a telerobotic research platform in space. References 1 and 2 are the proceedings of two workshops sponsored by the committee during its June 1991, through May 1992 term. The focus of the committee for the June 1992 - May 1993 term will be to further define to the recommended platform in space and to add an additional discipline which includes aircraft related GN&C issues. To the latter end members performing aircraft related research will be added to the committee. (A preliminary assessment of future opportunities in aircraft-related GN&C research has been included as appendix A.)

  10. 2008 Accomplishments for CEV Parachute Assembly System (CPAS)

    NASA Technical Reports Server (NTRS)

    Martin, Ricardo

    2009-01-01

    The Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS) project is responsible for the design, development, fabrication, qualification and delivery of the CEV parachute system to support the Orion pad/ascent flight tests and the first three orbital flight tests (including the first human mission). This article will discuss the technical and research achievements accomplished in calendar year 2008, broken into three key categories: prototype testing and analysis (also referred to as the Generation 1 design), system requirements definition and design of the flight engineering development unit, and support for the Orion vehicle flight testing (primarily Pad-Abort 1).

  11. Environmental Measurements Laboratory fiscal year 1998: Accomplishments and technical activities

    SciTech Connect

    Erickson, M.D.

    1999-01-01

    The Environmental Measurements Laboratory (EML) is government-owned, government-operated, and programmatically under the DOE Office of Environmental Management. The Laboratory is administered by the Chicago Operations Office. EML provides program management, technical assistance and data quality assurance for measurements of radiation and radioactivity relating to environmental restoration, global nuclear nonproliferation, and other priority issues for the Department of Energy, as well as for other government, national, and international organizations. This report presents the technical activities and accomplishments of EML for Fiscal Year 1998.

  12. Accomplishments of the Oak Ridge National Laboratory Seed Money program

    SciTech Connect

    Not Available

    1986-09-01

    In 1974, a modest program for funding new, innovative research was initiated at ORNL. It was called the ''Seed Money'' program and has become part of a larger program, called Exploratory R and D, which is being carried out at all DOE national laboratories. This report highlights 12 accomplishments of the Seed Money Program: nickel aluminide, ion implantation, laser annealing, burn meter, Legionnaires' disease, whole-body radiation counter, the ANFLOW system, genetics and molecular biology, high-voltage equipment, microcalorimeter, positron probe, and atom science. (DLC)

  13. Accomplishments of the Oak Ridge National Laboratory Seed Money program

    DOE R&D Accomplishments Database

    1986-09-01

    In 1974, a modest program for funding new, innovative research was initiated at ORNL. It was called the "Seed Money" program and has become part of a larger program, called Exploratory R and D, which is being carried out at all DOE national laboratories. This report highlights 12 accomplishments of the Seed Money Program: nickel aluminide, ion implantation, laser annealing, burn meter, Legionnaires' disease, whole-body radiation counter, the ANFLOW system, genetics and molecular biology, high-voltage equipment, microcalorimeter, positron probe, and atom science. (DLC)

  14. Fort Collins Science Center fiscal year 2010 science accomplishments

    USGS Publications Warehouse

    Wilson, Juliette T.

    2011-01-01

    The scientists and technical professionals at the U.S. Geological Survey (USGS), Fort Collins Science Center (FORT), apply their diverse ecological, socioeconomic, and technological expertise to investigate complicated ecological problems confronting managers of the Nation's biological resources. FORT works closely with U.S. Department of the Interior (DOI) agency scientists, the academic community, other USGS science centers, and many other partners to provide critical information needed to help answer complex natural-resource management questions. In Fiscal Year 2010 (FY10), FORT's scientific and technical professionals conducted ongoing, expanded, and new research vital to the science needs and management goals of DOI, other Federal and State agencies, and nongovernmental organizations in the areas of aquatic systems and fisheries, climate change, data and information integration and management, invasive species, science support, security and technology, status and trends of biological resources (including the socioeconomic aspects), terrestrial and freshwater ecosystems, and wildlife resources, including threatened and endangered species. This report presents selected FORT science accomplishments for FY10 by the specific USGS mission area or science program with which each task is most closely associated, though there is considerable overlap. The report also includes all FORT publications and other products published in FY10, as well as staff accomplishments, appointments, committee assignments, and invited presentations.

  15. Accomplishing Transformative Research in a Challenging Fiscal Environment

    NASA Astrophysics Data System (ADS)

    Mitchell, E. J.; Paxton, L. J.; Bust, G.

    2014-12-01

    The shift in funding is forcing scientists to promise transformative research for a pittance. To accomplish this, researchers need to transform their methodology to include societal buy-in, use of commercial off-the-shelf (COTS) technology, and cross-discipline platform usage. As the cutting edge of research expands to view the system on the global scale with extremely fine resolution, fiscally reasonable budgets present a challenge to be met. Consider how do we measure a specific variable over 45-degrees of latitude in an isolated and hostile region of Earth - the total electron count over the South Pole? This work examines this transformative research using hosted payloads on buoys, balloons, and unmanned aerial vehicles (UAVs). We will show cutting edge research occurring simultaneous with education and public outreach, offering societal buy-in through interactive websites and student-built hosted payloads. These interactions provide a vision to the public and a new database to the scientists. The use of COTS technology and cross-discipline (oceanography and space) platforms keep the cost low. We will discuss a general methodology for accomplishing transformative research in a challenging fiscal environment through integration of COTS technology, assimilative and first principle models, and observing systems simulation experiments (OSSEs).

  16. Gender similarities and differences.

    PubMed

    Hyde, Janet Shibley

    2014-01-01

    Whether men and women are fundamentally different or similar has been debated for more than a century. This review summarizes major theories designed to explain gender differences: evolutionary theories, cognitive social learning theory, sociocultural theory, and expectancy-value theory. The gender similarities hypothesis raises the possibility of theorizing gender similarities. Statistical methods for the analysis of gender differences and similarities are reviewed, including effect sizes, meta-analysis, taxometric analysis, and equivalence testing. Then, relying mainly on evidence from meta-analyses, gender differences are reviewed in cognitive performance (e.g., math performance), personality and social behaviors (e.g., temperament, emotions, aggression, and leadership), and psychological well-being. The evidence on gender differences in variance is summarized. The final sections explore applications of intersectionality and directions for future research.

  17. Separations and Waste Forms Research and Development FY 2013 Accomplishments Report

    SciTech Connect

    Not Listed

    2013-12-01

    The Separations and Waste Form Campaign (SWFC) under the U.S. Department of Energy (DOE) Fuel Cycle Research and Development Program (FCRD) is responsible for developing advanced separation and waste form technologies to support the various fuel cycle options defined in the DOE Nuclear Energy Research and Development Roadmap, Report to Congress, April 2010. The fiscal year (FY) 2013 accomplishments report provides a highlight of the results of the research and development (R&D) efforts performed within SWFC in FY 2013. Each section contains a high-level overview of the activities, results, technical point of contact, applicable references, and documents produced during the fiscal year. This report briefly outlines campaign management and integration activities, but the intent of the report is to highlight the many technical accomplishments made during FY 2013.

  18. Fort Collins Science Center - Fiscal Year 2008 Science Accomplishments

    USGS Publications Warehouse

    Wilson, Juliette T.

    2009-01-01

    Public land and natural resource managers in the United States are confronted with increasingly complex decisions that have important ramifications for both ecological and human systems. The scientists and technical professionals at the U.S. Geological Survey (USGS) Fort Collins Science Center (FORT) contribute a unique blend of ecological, socioeconomic, and technological expertise to investigating complicated ecological problems that address critical management questions. In Fiscal Year 2008 (FY08), FORT's scientific and technical professionals continued research vital to the science and management needs of U.S. Department of the Interior agencies and other entities. This annual report describes select FY08 accomplishments in research and technical assistance involving biological information management and delivery; aquatic, riparian, and managed-river ecosystems; invasive species; status and trends of biological resources (including human dimensions and social science); terrestrial ecosystems; and fish and wildlife resources.

  19. Recent Accomplishments in Laser-Photovoltaic Wireless Power Transmission

    NASA Technical Reports Server (NTRS)

    Fikes, John C.; Henley, Mark W.; Mankins, John C.; Howell, Joe T.; Fork, Richard L.; Cole, Spencer T.; Skinner, Mark

    2003-01-01

    Wireless power transmission can be accomplished over long distances using laser power sources and photovoltaic receivers. Recent research at AMOS has improved our understanding of the use of this technology for practical applications. Research by NASA, Boeing, the University of Alabama-Huntsville, the University of Colorado, Harvey Mudd College, and the Naval Postgraduate School has tested various commercial lasers and photovoltaic receiver configurations. Lasers used in testing have included gaseous argon and krypton, solid-state diodes, and fiber optic sources, at wavelengths ranging from the visible to the near infra-red. A variety of Silicon and Gallium Arsenide photovoltaic have been tested with these sources. Safe operating procedures have been established, and initial tests have been conducted in the open air at AMOS facilities. This research is progressing toward longer distance ground demonstrations of the technology and practical near-term space demonstrations.

  20. Fiscal Year 2005 Solar Radiometry and Metrology Task Accomplishments

    SciTech Connect

    Myers, D.; Andreas, A.; Reda, I.; Gotseff, P.; Wilcox, S.; Stoffel, T.; Anderberg, M.; Kay, B.; Bowen, A.

    2005-11-01

    The National Renewable Energy Laboratory (NREL) Solar Radiometry and Metrology task provides traceable optical radiometric calibrations and measurements to photovoltaic (PV) researchers and the PV industry. Traceability of NREL solar radiometer calibrations to the World Radiometric Reference (WRR) was accomplished during Pyrheliometer Comparison at NREL in October 2004. Ten spectral and more than 200 broadband radiometers for solar measurements were calibrated this year. We measured detailed spectral distributions of the NREL and PV industry Pulsed Solar Simulators and are analyzing the influence of environmental variables on radiometer uncertainty. New systems for indoor and outdoor solar radiometer calibrations and ultraviolet (UV) spectral measurements and UV radiometer calibrations were purchased and tested. Optical metrology functions support the NREL Measurement and Characterization Task effort for ISO 17025 accreditation of NREL Solar Reference Cell Calibrations and have been integrated into the NREL quality system and audited for ISO17025 compliance.

  1. Langley rotorcraft structural dynamics program: Background, status, accomplishments, plans

    NASA Technical Reports Server (NTRS)

    Kvaternik, Raymond G.

    1989-01-01

    Excessive vibration is the most common technical problem to arise as a show stopper in the development of a new rotorcraft. Vibration predictions have not been relied on by the industry during design because of deficiencies in finite element dynamic analyses. A rotorcraft structural dynamics program aimed at meeting the industry's long-term needs in this key technical area was implemented at Langley in 1984. The subject program is a cooperative effort involving NASA, the Army, academia, and the helicopter industry in a series of generic research activities directed at establishing the critical elements of the technology base needed for development of a superior finite element dynamics design analysis capability in the U.S. helicopter industry. An executive overview of the background, status, accomplishments, and future direction of this program is presented.

  2. Accomplishments at NASA Langley Research Center in rotorcraft aerodynamics technology

    NASA Technical Reports Server (NTRS)

    Wilson, John C.

    1988-01-01

    In recent years, the development of aerodynamic technology for rotorcraft has continued successfully at NASA LaRC. Though the NASA Langley Research Center is not the lead NASA center in this area, the activity was continued due to facilities and individual capabilities which are recognized as contributing to helicopter research needs of industry and government. Noteworthy accomplishments which contribute to advancing the state of rotorcraft technology in the areas of rotor design, airfoil research, rotor aerodynamics, and rotor/fuselage interaction aerodynamics are described. Rotor designs were defined for current helicopters and evaluated in wind tunnel testing. These designs have incorporated advanced airfoils defined analytically and also proven in wind tunnel tests. A laser velocimetry system has become a productive tool for experimental definition of rotor inflow/wake and is providing data for rotorcraft aerodynamic code validation.

  3. FY 2006 Accomplishment Colony - "Services and Interfaces to Support Large Numbers of Processors"

    SciTech Connect

    Jones, T; Kale, L; Moreira, J; Mendes, C; Chakravorty, S; Tauferner, A; Inglett, T

    2006-06-30

    The Colony Project is developing operating system and runtime system technology to enable efficient general purpose environments on tens of thousands of processors. To accomplish this, we are investigating memory management techniques, fault management strategies, and parallel resource management schemes. Recent results show promising findings for scalable strategies based on processor virtualization, in-memory checkpointing, and parallel aware modifications to full featured operating systems.

  4. Multivariate Time Series Similarity Searching

    PubMed Central

    Wang, Jimin; Zhu, Yuelong; Li, Shijin; Wan, Dingsheng; Zhang, Pengcheng

    2014-01-01

    Multivariate time series (MTS) datasets are very common in various financial, multimedia, and hydrological fields. In this paper, a dimension-combination method is proposed to search similar sequences for MTS. Firstly, the similarity of single-dimension series is calculated; then the overall similarity of the MTS is obtained by synthesizing each of the single-dimension similarity based on weighted BORDA voting method. The dimension-combination method could use the existing similarity searching method. Several experiments, which used the classification accuracy as a measure, were performed on six datasets from the UCI KDD Archive to validate the method. The results show the advantage of the approach compared to the traditional similarity measures, such as Euclidean distance (ED), cynamic time warping (DTW), point distribution (PD), PCA similarity factor (SPCA), and extended Frobenius norm (Eros), for MTS datasets in some ways. Our experiments also demonstrate that no measure can fit all datasets, and the proposed measure is a choice for similarity searches. PMID:24895665

  5. Multivariate time series similarity searching.

    PubMed

    Wang, Jimin; Zhu, Yuelong; Li, Shijin; Wan, Dingsheng; Zhang, Pengcheng

    2014-01-01

    Multivariate time series (MTS) datasets are very common in various financial, multimedia, and hydrological fields. In this paper, a dimension-combination method is proposed to search similar sequences for MTS. Firstly, the similarity of single-dimension series is calculated; then the overall similarity of the MTS is obtained by synthesizing each of the single-dimension similarity based on weighted BORDA voting method. The dimension-combination method could use the existing similarity searching method. Several experiments, which used the classification accuracy as a measure, were performed on six datasets from the UCI KDD Archive to validate the method. The results show the advantage of the approach compared to the traditional similarity measures, such as Euclidean distance (ED), cynamic time warping (DTW), point distribution (PD), PCA similarity factor (SPCA), and extended Frobenius norm (Eros), for MTS datasets in some ways. Our experiments also demonstrate that no measure can fit all datasets, and the proposed measure is a choice for similarity searches. PMID:24895665

  6. NASA Intelligent Systems Project: Results, Accomplishments and Impact on Science Missions

    NASA Technical Reports Server (NTRS)

    Coughlan, Joseph C.

    2005-01-01

    The Intelligent Systems Project was responsible for much of NASA's programmatic investment in artificial intelligence and advanced information technologies. IS has completed three major project milestones which demonstrated increased capabilities in autonomy, human centered computing, and intelligent data understanding. Autonomy involves the ability of a robot to place an instrument on a remote surface with a single command cycle. Human centered computing supported a collaborative, mission centric data and planning system for the Mars Exploration Rovers and data understanding has produced key components of a terrestrial satellite observation system with automated modeling and data analysis capabilities. This paper summarizes the technology demonstrations and metrics which quantify and summarize these new technologies which are now available for future Nasa missions.

  7. Project ALERT Accomplishments by Objectives. Final Performance Report. Three-Year Results.

    ERIC Educational Resources Information Center

    Wayne State Univ., Detroit, MI. Coll. of Education.

    Project ALERT (Adult Literacy Enhanced & Redefined through Training) was a 3-year effort to develop and deploy a number of innovative approaches to delivering workplace literacy programs to business partners, including manufacturers and unions. The project designed, developed, and implemented workplace literacy programs tailored to the…

  8. The Qualitative Similarity Hypothesis

    ERIC Educational Resources Information Center

    Paul, Peter V.; Lee, Chongmin

    2010-01-01

    Evidence is presented for the qualitative similarity hypothesis (QSH) with respect to children and adolescents who are d/Deaf or hard of hearing. The primary focus is on the development of English language and literacy skills, and some information is provided on the acquisition of English as a second language. The QSH is briefly discussed within…

  9. Solubility and speciation results from oversaturation experiments on neptunium, plutonium and americium in a neutral electrolyte with a total carbonate similar to water from Yucca Mountain Region Well UE- 25p No. 1

    SciTech Connect

    Torretto, P.; Becraft, K.; Prussin, T.; Roberts, K.; Carpenter, S.; Hobart, D.; Nitsche, H.

    1995-12-01

    Solubility and speciation are important in understanding aqueous radionuclide transport through the geosphere. They define the source term for transport retardation processes such as sorption and colloid formation. Solubility and speciation data are useful in verifying the validity of geochemical codes that are a part of predictive transport models. Solubility experiments will approach solution equilibrium from both oversaturation and undersaturation. In these experiments, we have approached the solubility equilibrium from oversaturation, Results are given for solubility and speciation experiments from oversaturation of {sup 237} NpO{sub 2}{sup +} {sup 239}Pu{sup 4+}, and {sup 241}Am{sup 3+}/Nd{sup 3+} in a neutral electrolyte containing a total carbonate concentration similar to groundwater from the Yucca Mountain region, Nevada, which is being investigated as a potential high-level nuclear waste disposal site, at 25{degrees}C and three pH values. In these experiments, the solubilitycontrolling steady-state solids were identified and the speciation and/or oxidation states present in the supernatant solutions were determined.

  10. Indexing Similar DNA Sequences

    NASA Astrophysics Data System (ADS)

    Huang, Songbo; Lam, T. W.; Sung, W. K.; Tam, S. L.; Yiu, S. M.

    To study the genetic variations of a species, one basic operation is to search for occurrences of patterns in a large number of very similar genomic sequences. To build an indexing data structure on the concatenation of all sequences may require a lot of memory. In this paper, we propose a new scheme to index highly similar sequences by taking advantage of the similarity among the sequences. To store r sequences with k common segments, our index requires only O(n + NlogN) bits of memory, where n is the total length of the common segments and N is the total length of the distinct regions in all texts. The total length of all sequences is rn + N, and any scheme to store these sequences requires Ω(n + N) bits. Searching for a pattern P of length m takes O(m + m logN + m log(rk)psc(P) + occlogn), where psc(P) is the number of prefixes of P that appear as a suffix of some common segments and occ is the number of occurrences of P in all sequences. In practice, rk ≤ N, and psc(P) is usually a small constant. We have implemented our solution and evaluated our solution using real DNA sequences. The experiments show that the memory requirement of our solution is much less than that required by BWT built on the concatenation of all sequences. When compared to the other existing solution (RLCSA), we use less memory with faster searching time.

  11. EarthScope Education and Outreach: Accomplishments and Emerging Opportunities

    NASA Astrophysics Data System (ADS)

    Robinson, S.; Ellins, K. K.; Semken, S. C.; Arrowsmith, R.

    2014-12-01

    EarthScope's Education and Outreach (E&O) program aims to increase public awareness of Earth science and enhance geoscience education at the K-12 and college level. The program is distinctive among major geoscience programs in two ways. First, planning for education and public engagement occurred in tandem with planning for the science mission. Second, the NSF EarthScope program includes funding support for education and outreach. In this presentation, we highlight key examples of the program's accomplishments and identify emerging E&O opportunities. E&O efforts have been collaboratively led by the EarthScope National Office (ESNO), IRIS, UNAVCO, the EarthScope Education and Outreach Subcommittee (EEOSC) and PI-driven EarthScope projects. Efforts by the EEOSC, guided by an EarthScope Education and Outreach Implementation Plan that is periodically updated, focus EarthScope E&O. EarthScope demonstrated early success in engaging undergraduate students (and teachers) in its mission through their involvement in siting USArray across the contiguous U.S. Funded E&O programs such as TOTLE, Illinois EarthScope, CEETEP (for K-12), InTeGrate and GETSI (for undergraduates) foster use of freely available EarthScope data and research findings. The Next Generation Science Standards, which stress science and engineering practices, offer an opportunity for alignment with existing EarthScope K-12 educational resources, and the EEOSC recommends focusing efforts on this task. The EEOSC recognizes the rapidly growing use of mobile smart devices by the public and in formal classrooms, which bring new opportunities to connect with the public and students. This will capitalize on EarthScope's already prominent social media presence, an effort that developed to accomplish one of the primary goals of the EarthScope E&O Implementation Plan to "Create a high-profile public identity for EarthScope" and to "Promote science literacy and understanding of EarthScope among all audiences through

  12. Accomplishment level and satisfaction with social participation of older adults: association with quality of life and best correlates

    PubMed Central

    Desrosiers, Johanne; Whiteneck, Gale

    2012-01-01

    Purpose This study aimed to (1) explore whether quality of life (QOL) is more associated with satisfaction with social participation (SP) than with level of accomplishment in SP and (2) examine respective correlates of accomplishment level and satisfaction with SP. Methods A cross-sectional design was used with a convenience sample of 155 older adults (mean age = 73.7; 60% women) having various levels of activity limitations. Accomplishment level and satisfaction with SP (dependent variables) were estimated with the social roles items of the assessment of life habits. Potential correlates were human functioning components. Results Correlations between QOL and accomplishment level and satisfaction with SP did not differ (P = 0.71). However, best correlates of accomplishment level and satisfaction with SP were different. Higher accomplishment level of SP was best explained by younger age, activity level perceived as stable, no recent stressing event, better well-being, higher activity level, and fewer obstacles in “Physical environment and accessibility” (R2 = 0.79). Greater satisfaction with SP was best explained by activity level perceived as stable, better self-perceived health, better well-being, higher activity level, and more facilitators in “Social support and attitudes” (R2 = 0.51). Conclusion With some exceptions, these best correlates may be positively modified and thus warrant special attention in rehabilitation interventions. PMID:20237957

  13. Towards Personalized Medicine: Leveraging Patient Similarity and Drug Similarity Analytics

    PubMed Central

    Zhang, Ping; Wang, Fei; Hu, Jianying; Sorrentino, Robert

    2014-01-01

    The rapid adoption of electronic health records (EHR) provides a comprehensive source for exploratory and predictive analytic to support clinical decision-making. In this paper, we investigate how to utilize EHR to tailor treatments to individual patients based on their likelihood to respond to a therapy. We construct a heterogeneous graph which includes two domains (patients and drugs) and encodes three relationships (patient similarity, drug similarity, and patient-drug prior associations). We describe a novel approach for performing a label propagation procedure to spread the label information representing the effectiveness of different drugs for different patients over this heterogeneous graph. The proposed method has been applied on a real-world EHR dataset to help identify personalized treatments for hypercholesterolemia. The experimental results demonstrate the effectiveness of the approach and suggest that the combination of appropriate patient similarity and drug similarity analytics could lead to actionable insights for personalized medicine. Particularly, by leveraging drug similarity in combination with patient similarity, our method could perform well even on new or rarely used drugs for which there are few records of known past performance. PMID:25717413

  14. Towards personalized medicine: leveraging patient similarity and drug similarity analytics.

    PubMed

    Zhang, Ping; Wang, Fei; Hu, Jianying; Sorrentino, Robert

    2014-01-01

    The rapid adoption of electronic health records (EHR) provides a comprehensive source for exploratory and predictive analytic to support clinical decision-making. In this paper, we investigate how to utilize EHR to tailor treatments to individual patients based on their likelihood to respond to a therapy. We construct a heterogeneous graph which includes two domains (patients and drugs) and encodes three relationships (patient similarity, drug similarity, and patient-drug prior associations). We describe a novel approach for performing a label propagation procedure to spread the label information representing the effectiveness of different drugs for different patients over this heterogeneous graph. The proposed method has been applied on a real-world EHR dataset to help identify personalized treatments for hypercholesterolemia. The experimental results demonstrate the effectiveness of the approach and suggest that the combination of appropriate patient similarity and drug similarity analytics could lead to actionable insights for personalized medicine. Particularly, by leveraging drug similarity in combination with patient similarity, our method could perform well even on new or rarely used drugs for which there are few records of known past performance. PMID:25717413

  15. Fort Collins Science Center: Fiscal Year 2007 Accomplishments

    USGS Publications Warehouse

    Wilson, J.T.

    2008-01-01

    In Fiscal Year 2007 (FY07), the U.S. Geological Survey (USGS) Fort Collins Science Center (FORT) continued research vital to U.S. Department of the Interior science and management needs and associated USGS programmatic goals. FORT work also supported the science needs of other government agencies as well as private cooperators. Specifically, FORT scientific research and technical assistance focused on client and partner needs and goals in the areas of biological information management, fisheries and aquatic systems, invasive species, status and trends of biological resources, terrestrial ecosystems, and wildlife resources. In addition, FORT's 5-year strategic plan was refined to incorporate focus areas identified in the USGS strategic science plan, including ecosystem-landscape analysis, global climate change, and energy and mineral resource development. As a consequence, several science projects initiated in FY07 were either entirely new research dor amplifications of existing work. Highlights of FORT project accomplishments are described below under the USGS science program with which each task is most closely associated. The work of FORT's 6 branches (Aquatic Systems and Technology Applications, Ecosystem Dynamics, Information Science, Invasive Species Science, Policy Analysis and Science Assistance, and Species and Habitats of Federal Interest) often involves major partnerships with other agencies or cooperation with other USGS disciplines (Geology, Geography, Water Resources) and the Geospatial Information Office.

  16. Overexpression of the Candida albicans ALA1 Gene in Saccharomyces cerevisiae Results in Aggregation following Attachment of Yeast Cells to Extracellular Matrix Proteins, Adherence Properties Similar to Those of Candida albicans

    PubMed Central

    Gaur, Nand K.; Klotz, Stephen A.; Henderson, Ramona L.

    1999-01-01

    Candida albicans maintains a commensal relationship with human hosts, probably by adhering to mucosal tissue in a variety of physiological conditions. We show that adherence due to the C. albicans gene ALA1 when transformed into Saccharomyces cerevisiae, is comprised of two sequential steps. Initially, C. albicans rapidly attaches to extracellular matrix (ECM) protein-coated magnetic beads in small numbers (the attachment phase). This is followed by a relatively slower step in which cell-to-cell interactions predominate (the aggregation phase). Neither of these phases is observed in S. cerevisiae. However, expression of the C. albicans ALA1 gene from a low-copy vector causes S. cerevisiae transformants to attach to ECM-coated magnetic beads without appreciable aggregation. Expression of ALA1 from a high-copy vector results in both attachment and aggregation. Moreover, transcriptional fusion of ALA1 with the galactose-inducible promoters GALS, GALL, and GAL1, allowing for low, moderate, and high levels of inducible transcription, respectively, causes attachment and aggregation that correlates with the strength of the GAL promoter. The adherence of C. albicans and S. cerevisiae overexpressing ALA1 to a number of protein ligands occurs over a broad pH range, is resistant to shear forces generated by vortexing, and is unaffected by the presence of sugars, high salt levels, free ligands, or detergents. Adherence is, however, inhibited by agents that disrupt hydrogen bonds. The similarities in the adherence and aggregation properties of C. albicans and S. cerevisiae overexpressing ALA1 suggest a role in adherence and aggregation for ALA1 and ALA1-like genes in C. albicans. PMID:10531265

  17. Astrobiology at Arizona State University: An Overview of Accomplishments

    NASA Technical Reports Server (NTRS)

    Farmer, Jack

    2005-01-01

    During our five years as an NAI charter member, Arizona State University sponsored a broadly-based program of research and training in Astrobiology to address the origin, evolution and distribution of life in the Solar System. With such a large, diverse and active team, it is not possible in a reasonable space, to cover all details of progress made over the entire five years. The following paragraphs provide an overview update of the specific research areas pursued by the Arizona State University (ASU) Astrobiology team at the end of Year 5 and at the end of the 4 month and subsequent no cost month extensions. for a more detailed review, the reader is referred to the individual annual reports (and Executive Summaries) submitted to the NAI at the end of each of our five years of membership. Appended in electronic form is our complete publication record for all five years, plus a tabulation of undergraduates, graduate students and post-docs supported by our program during this time. The overarching theme of ASU s Astrobiology program was "Exploring the Living Universe: Studies of the Origin, Evolution and Distribution of Life in the Solar System". The NAi-funded research effort was organized under three basic sub- themes: 1. Origins of the Basic Building Blocks of Life. 2. Early Biosphere Evolution. and 3. Exploring for Life in the Solar System. These sub-theme areas were in turn, subdivided into Co-lead research modules. In the paragraphs that follow, accomplishments for individual research modules are briefly outlined, and the key participants presented in tabular form. As noted, publications for each module are appended in hard copy and digital formats, under the name(s) of lead co-Is.

  18. Performance Standards and Domains of College Students' Personal Accomplishments.

    ERIC Educational Resources Information Center

    Gaeddert, William P.; And Others

    A number of researchers have described individual differences in achievement goals and performance standards. To explore similarities and differences in these theories, and to provide an instrument to measure them, 273 female and 88 male college students responded to items designed to measure each of the dimensions defined by these theories. The…

  19. An Evaluation of State Energy Program Accomplishments: 2002 Program Year

    SciTech Connect

    Schweitzer, M.

    2005-07-13

    SEP activities performed by the states during the 2002 program year, based on primary data provided by the states themselves. This is the second systematic evaluation of SEP accomplishments performed by Oak Ridge National Laboratory (ORNL) for DOE. A report documenting the findings of the first study was published in January 2003 (Schweitzer et.al., 2003).

  20. Similarity, invariance, and musical variation.

    PubMed

    McAdams, S; Matzkin, D

    2001-06-01

    Perceptual similarity underlies a number of important psychological properties of musical materials, including perceptual invariance under transformation, categorization, recognition, and the sense of familiarity. Mental processes involved in the perception of musical similarity may be an integral part of the functional logic of music composition and thus underly important aspects of musical experience. How much and in what ways can musical materials be varied and still be considered as perceptually related or as belonging to the same category? The notions of musical material, musical variation, perceptual similarity and invariance, and form-bearing dimensions are considered in this light. Recent work on similarity perception has demonstrated that the transformation space for a given musical material is limited by several factors ranging from degree of match of the values of auditory attributes of the events composing the sequences to their relations of various levels of abstraction and to the degree that the transformation respects the grammar of the musical system within which the material was composed. These notions and results are considered in the light of future directions of research, particularly concerning the role of similarity and invariance in the understanding of musical form during listening.

  1. Similarity, invariance, and musical variation.

    PubMed

    McAdams, S; Matzkin, D

    2001-06-01

    Perceptual similarity underlies a number of important psychological properties of musical materials, including perceptual invariance under transformation, categorization, recognition, and the sense of familiarity. Mental processes involved in the perception of musical similarity may be an integral part of the functional logic of music composition and thus underly important aspects of musical experience. How much and in what ways can musical materials be varied and still be considered as perceptually related or as belonging to the same category? The notions of musical material, musical variation, perceptual similarity and invariance, and form-bearing dimensions are considered in this light. Recent work on similarity perception has demonstrated that the transformation space for a given musical material is limited by several factors ranging from degree of match of the values of auditory attributes of the events composing the sequences to their relations of various levels of abstraction and to the degree that the transformation respects the grammar of the musical system within which the material was composed. These notions and results are considered in the light of future directions of research, particularly concerning the role of similarity and invariance in the understanding of musical form during listening. PMID:11458867

  2. Research on the International Space Station: Understanding Future Potential from Current Accomplishments

    NASA Technical Reports Server (NTRS)

    Robinson, Julie A.

    2007-01-01

    In November 2007, the International Space Station (ISS) will have supported seven years of continuous presence in space, with 15 Expeditions completed. These years have been characterized by the numerous technical challenges of assembly as well as operational and logistical challenges related to the availability of transportation by the Space Shuttle. During this period, an active set of early research objectives have also been accomplished alongside the assembly. This paper will review the research accomplishments on ISS to date, with the objective of drawing insights on the potential of future research following completion of ISS assembly. By the end of Expedition 15, an expected 121 U.S.-managed investigations will have been conducted on ISS, with 91 of these completed. Many of these investigations include multiple scientific objectives, with an estimated total of 334 scientists served. Through February 2007, 101 scientific publications have been identified. Another 184 investigations have been sponsored by ISS international partners, which independently track their scientists served and results publication. Through this survey of U.S. research completed on ISS, three different themes will be addressed: (1) How have constraints on transportation of mass to orbit affected the types of research successfully completed on the ISS to date? What lessons can be learned for increasing the success of ISS as a research platform during the period following the retirement of the Space Shuttle? (2) How have constraints on crew time for research during assembly and the active participation of crewmembers as scientists affected the types of research successfully completed on the ISS to date? What lessons can be learned for optimizing research return following the increase in capacity from 3 to 6 crewmembers (planned for 2009)? What lessons can be learned for optimizing research return after assembly is complete? (3) What do early research results indicate about the various

  3. Reconstructing propagation networks with temporal similarity

    PubMed Central

    Liao, Hao; Zeng, An

    2015-01-01

    Node similarity significantly contributes to the growth of real networks. In this paper, based on the observed epidemic spreading results we apply the node similarity metrics to reconstruct the underlying networks hosting the propagation. We find that the reconstruction accuracy of the similarity metrics is strongly influenced by the infection rate of the spreading process. Moreover, there is a range of infection rate in which the reconstruction accuracy of some similarity metrics drops nearly to zero. To improve the similarity-based reconstruction method, we propose a temporal similarity metric which takes into account the time information of the spreading. The reconstruction results are remarkably improved with the new method. PMID:26086198

  4. Reconstructing propagation networks with temporal similarity.

    PubMed

    Liao, Hao; Zeng, An

    2015-01-01

    Node similarity significantly contributes to the growth of real networks. In this paper, based on the observed epidemic spreading results we apply the node similarity metrics to reconstruct the underlying networks hosting the propagation. We find that the reconstruction accuracy of the similarity metrics is strongly influenced by the infection rate of the spreading process. Moreover, there is a range of infection rate in which the reconstruction accuracy of some similarity metrics drops nearly to zero. To improve the similarity-based reconstruction method, we propose a temporal similarity metric which takes into account the time information of the spreading. The reconstruction results are remarkably improved with the new method. PMID:26086198

  5. Accomplishments and Compromises in Prediction Research for World Records and Best Performances in Track and Field and Swimming

    ERIC Educational Resources Information Center

    Liu, Yuanlong; Paul, Stanley; Fu, Frank H.

    2012-01-01

    The conductors of this study reviewed prediction research and studied the accomplishments and compromises in predicting world records and best performances in track and field and swimming. The results of the study showed that prediction research only promises to describe the historical trends in track and field and swimming performances, to study…

  6. Perceived Similarity With Gay Men Mediates the Effect of Antifemininity on Heterosexual Men's Antigay Prejudice.

    PubMed

    Martínez, Carmen; Vázquez, Carolina; Falomir-Pichastor, Juan Manuel

    2015-01-01

    This research examined the hypothesis that heterosexual men's motivation to differentiate themselves from gay men mediates the relationship between the antifemininity norm of masculinity and antigay prejudice. We assessed masculinity through three concepts: status, thoughness, and antifemininity. Participants then reported their perceived similarity with gay men and their antigay prejudice. The results showed that antifemininity was the best predictor of both perceived similarity and antigay prejudice: The more people endorsed the antifemininity norm, the more they perceived themselves as dissimilar from gay men and showed antigay prejudice. More important, perceived similarity mediated the effect of antifemininity on antigay prejudice. These findings provide direct evidence for the link between masculinity and the motivation to differentiate oneself from gay men, and they suggest that antigay prejudice accomplishes the identity function of maintaining unambiguous gender boundaries.

  7. Similarity Solutions of the Compressible Flow Equations for a General Equation of State

    NASA Astrophysics Data System (ADS)

    Boyd, Zachary; Ramsey, Scott; Baty, Roy

    2015-11-01

    The Euler compressible flow equations admit discontinuous (e.g. shock) solutions regardless of the equation of state (EOS) used to close them. In addition, certain classes of initial conditions and EOS admit special flows known as similarity solutions, including some containing shocks. These are useful (1) as test problems for hydrocodes, (2) as intermediate asymptotic estimates for non-symmetric problems, and (3) in forecasting experimental results. To date, the vast majority of work pertaining to similarity solutions of the Euler equations has been accomplished in the context of the ideal gas EOS; the case where the material is arbitrary is less well-understood. In this work, we classify using Lie-group analysis those materials which admit similarity solutions. We also indicate how such solutions may be found for a variety of materials of interest, including those characterized by particular forms of the Gruneisen EOS. Graduate Student Department of Mathematics, UCLA.

  8. Can Distributed Volunteers Accomplish Massive Data Analysis Tasks?

    NASA Technical Reports Server (NTRS)

    Kanefsky, B.; Barlow, N. G.; Gulick, V. C.

    2001-01-01

    We argue that many image analysis tasks can be performed by distributed amateurs. Our pilot study, with crater surveying and classification, has produced encouraging results in terms of both quantity (100,000 crater entries in 2 months) and quality. Additional information is contained in the original extended abstract.

  9. Supporting and Rewarding Accomplished Teaching: Insights from Austin, Texas

    ERIC Educational Resources Information Center

    Lussier, David F.; Forgione, Pascal D., Jr.

    2010-01-01

    This article explores the strategic compensation efforts of the Austin Independent School District (AISD) in Texas, which is piloting a system of supports and rewards for teachers and administrators. The article highlights the key components of this system, what it took to put a 4-year pilot program in place, and what results are emerging from…

  10. Some innovations and accomplishments of Ames Research Center since its inception

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The innovations and accomplishments of Ames Research Center from 1940 through 1966 are summarized and illustrated. It should be noted that a number of accomplishments were begun at the NASA Dryden Flight Research Facility before that facility became part of the Ames Research Center. Such accomplishments include the first supersonic flight, the first hypersonic flight, the lunar landing research vehicle, and the first digital fly-by-wire aircraft.

  11. Path similarity skeleton graph matching.

    PubMed

    Bai, Xiang; Latecki, Longin Jan

    2008-07-01

    This paper presents a novel framework to for shape recognition based on object silhouettes. The main idea is to match skeleton graphs by comparing the shortest paths between skeleton endpoints. In contrast to typical tree or graph matching methods, we completely ignore the topological graph structure. Our approach is motivated by the fact that visually similar skeleton graphs may have completely different topological structures. The proposed comparison of shortest paths between endpoints of skeleton graphs yields correct matching results in such cases. The skeletons are pruned by contour partitioning with Discrete Curve Evolution, which implies that the endpoints of skeleton branches correspond to visual parts of the objects. The experimental results demonstrate that our method is able to produce correct results in the presence of articulations, stretching, and occlusion.

  12. Accomplishments and challenges in literature data mining for biology.

    PubMed

    Hirschman, Lynette; Park, Jong C; Tsujii, Junichi; Wong, Limsoon; Wu, Cathy H

    2002-12-01

    We review recent results in literature data mining for biology and discuss the need and the steps for a challenge evaluation for this field. Literature data mining has progressed from simple recognition of terms to extraction of interaction relationships from complex sentences, and has broadened from recognition of protein interactions to a range of problems such as improving homology search, identifying cellular location, and so on. To encourage participation and accelerate progress in this expanding field, we propose creating challenge evaluations, and we describe two specific applications in this context.

  13. NASA's Heliophysics Theory Program - Accomplishments in Life Cycle Ending 2011

    NASA Technical Reports Server (NTRS)

    Grebowsky, J.

    2011-01-01

    NASA's Heliophysics Theory Program (HTP) is now into a new triennial cycle of funded research, with new research awards beginning in 2011. The theory program was established by the (former) Solar Terrestrial Division in 1980 to redress a weakness of support in the theory area. It has been a successful, evolving scientific program with long-term funding of relatively large "critical mass groups" pursuing theory and modeling on a scale larger than that available within the limits of traditional NASA Supporting Research and Technology (SR&T) awards. The results of the last 3 year funding cycle, just ended, contributed to ever more cutting edge theoretical understanding of all parts of the Sun-Earth Connection chain. Advances ranged from the core of the Sun out into the corona, through the solar wind into the Earth's magnetosphere and down to the ionosphere and lower atmosphere, also contributing to understanding the environments of other solar system bodies. The HTP contributions were not isolated findings but continued to contribute to the planning and implementation of NASA spacecraft missions and to the development of the predictive computer models that have become the workhorses for analyzing satellite and ground-based measurements.

  14. An Overview of SIMBIOS Program Activities and Accomplishments. Chapter 1

    NASA Technical Reports Server (NTRS)

    Fargion, Giulietta S.; McClain, Charles R.

    2003-01-01

    The SIMBIOS Program was conceived in 1994 as a result of a NASA management review of the agency's strategy for monitoring the bio-optical properties of the global ocean through space-based ocean color remote sensing. At that time, the NASA ocean color flight manifest included two data buy missions, the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) and Earth Observing System (EOS) Color, and three sensors, two Moderate Resolution Imaging Spectroradiometers (MODIS) and the Multi-angle Imaging Spectro-Radiometer (MISR), scheduled for flight on the EOS-Terra and EOS-Aqua satellites. The review led to a decision that the international assemblage of ocean color satellite systems provided ample redundancy to assure continuous global coverage, with no need for the EOS Color mission. At the same time, it was noted that non-trivial technical difficulties attended the challenge (and opportunity) of combining ocean color data from this array of independent satellite systems to form consistent and accurate global bio-optical time series products. Thus, it was announced at the October 1994 EOS Interdisciplinary Working Group meeting that some of the resources budgeted for EOS Color should be redirected into an intercalibration and validation program (McClain et al., 2002).

  15. NASA's Heliophysics Theory Program - Accomplishments in its Last Cycle

    NASA Astrophysics Data System (ADS)

    Grebowsky, J.

    2008-12-01

    NASA's Heliophysics Theory Program (HTP) is now into a new triennial cycle of funded research, with new research awards beginning in 2008. The theory program was established by the (former) Solar Terrestrial Division in 1980 to redress a weakness of support in the theory area. It has been a successful, evolving scientific program with long-term funding of relatively large "critical mass groups" pursuing theory and modeling on a scale larger than that available within the limits of traditional NASA Supporting Research and Technology (SR&T) awards. The results of the last 3 year funding cycle, just ended, contributed to ever more cutting edge theoretical understanding of all parts of the Sun-Earth Connection chain. Advances ranged from the core of the Sun out into the corona, through the solar wind into the Earth's magnetosphere and down to the ionosphere and lower atmosphere, also contributing to understanding the environments of other solar system bodies. The HTP contributions were not isolated findings but continued to contribute to the planning and implementation of NASA spacecraft missions and to the development of the predictive computer models that have become the workhorses for analyzing satellite and ground-based measurements.

  16. NASA's Heliophysics Theory Program - Accomplishments In Last Cycle Ending 2011

    NASA Astrophysics Data System (ADS)

    Grebowsky, J. M.; Summerlin, E. J.

    2011-12-01

    NASA's Heliophysics Theory Program is now into a new triennial cycle of funded research, with new research awards beginning in 2011. The theory program was established by the (former) Solar Terrestrial Division in 1980 to redress a weakness of support in the theory area. It has been a successful, evolving scientific program with long-term funding of relatively large "critical mass groups" pursuing theory and modeling on a scale larger than that available within the limits of traditional NASA Supporting Research and Technology awards. The results of the last 3 year funding cycle, just ended, contributed to ever more cutting edge theoretical understanding of all parts of the Sun-Earth Connection chain. Advances ranged from the core of the Sun out into the corona, through the solar wind into the Earth's magnetosphere and down to the ionosphere and lower atmosphere, also contributing to understanding the environments of other solar system bodies. The HTP contributions were not isolated findings but continued to contribute to the planning and implementation of NASA spacecraft missions and to the development of the predictive computer models that have become the workhorses for analyzing satellite and ground-based measurements.

  17. The International Space Station Research Opportunities and Accomplishments

    NASA Technical Reports Server (NTRS)

    Alleyne, Camille W.

    2011-01-01

    In 2010, the International Space Station (ISS) construction and assembly was completed to become a world-class scientific research laboratory. We are now in the era of utilization of this unique platform that facilitates ground-breaking research in the microgravity environment. There are opportunities for NASA-funded research; research funded under the auspice of the United States National Laboratory; and research funded by the International Partners - Japan, Europe, Russia and Canada. The ISS facilities offer an opportunity to conduct research in a multitude of disciplines such as biology and biotechnology, physical science, human research, technology demonstration and development; and earth and space science. The ISS is also a unique resource for educational activities that serve to motivate and inspire students to pursue careers in Science, Technology, Engineering and Mathematics. Even though we have just commenced full utilization of the ISS as a science laboratory, early investigations are yielding major results that are leading to such things as vaccine development, improved cancer drug delivery methods and treatment for debilitating diseases, such as Duchenne's Muscular Dystrophy. This paper

  18. What the Philosophical Interpretation of Quantum Theory Can Accomplish

    NASA Astrophysics Data System (ADS)

    Carrier, Martin

    I argue that philosophical reflection can contribute to a better understanding of physical theories by performing conceptual clarification, epistemological analysis and ontological exploration. I begin by reconstructing early ontological interpretations of quantum theory, i.e., by explaining Copenhagen instrumentalism and the shift toward a quantum realism. I turn to entanglement, whose chief philosophical challenge is to understand which deeper property of nature it reveals. The trouble is that the EPR-correlations it gives rise to are not produced by common causation. Conceptual analysis shows that this failure is due to the violation of separability in quantum theory. In entangled states, it is the composite state that is primary since it cannot be neatly divided into two states that unambiguously pertain to the partial systems. As a result, total states are not produced by an interaction among the parts. This feature can be interpreted in ontological terms as suggesting a holist picture of nature. Another question of philosophical import concerns the quantum measurement problem and the contribution decoherence makes to its solution. The conceptual point is what, precisely, this problem amounts to and what we require considering it settled. The issue that divides the philosophical factions is whether a solution needs to show that superpositions are actually destroyed or whether it suffices to demonstrate that superpositions become unobservable.

  19. Accomplishments in free-piston stirling tests at NASA GRC

    NASA Astrophysics Data System (ADS)

    Schreiber, Jeffrey G.; Skupinski, Robert C.

    2002-01-01

    A power system based on the Stirling Radioisotope Generator (SRG) has been identified for potential use on deep space missions, as well as for Mars rovers that may benefit from extended operation. The Department of Energy (DOE) has responsibility for developing the generator and the NASA Glenn Research Center (GRC) is supporting DOE in this effort. The generator is based on a free-piston Stirling power convertor that has been developed by the Stirling Technology Company (STC) under contract to DOE. The generator would be used as a high-efficiency alternative to the Radioisotope Thermoelectric Generators (RTGs) that have been used on many previous missions. The increased efficiency leads to a factor of 3 to 4 reduction in the inventory of plutonium required to heat the generator. GRC has been involved in the development of Stirling power conversion technology for over 25 years. The support provided to this project by GRC has many facets and draws upon the lab's scientists and engineers that have gained experience in applying their skills to the previous Stirling projects. This has created a staff with an understanding of the subtleties involved in applying their expertise to Stirling systems. Areas include materials, structures, tribology, controls, electromagnetic interference, permanent magnets, alternator analysis, structural dynamics, and cycle performance. One of the key areas of support to the project is in the performance testing of the free-piston Stirling convertors. Since these power convertors are the smallest, lowest power Stirling machines that have been tested at GRC, a new laboratory was equipped for this project. Procedures and test plans have been created, instrumentation and data systems developed, and Stirling convertors have been tested. This paper will describe the GRC test facility, the test procedures that are used, present some of the test results and outline plans for the future. .

  20. Sandia Technology: Engineering and science accomplishments, February 1995

    SciTech Connect

    1995-02-01

    Sandia National Laboratories is one of the Department of Energy`s primary research and development laboratories. Our essential mission is to support the national interests of the US in defense, energy, and the environment. Managed by Martin Marietta Corporation for DOE, Sandia focuses its resources on problems of national interest that require the integration of science and technology for their solution. We all hope that this period of sweeping alterations in international affairs will result in a successful transition from the Cold War to a period of sustainable global security and prosperity. In the meantime, our nation`s interests are best served by continued commitment to Sandia`s traditional responsibilities. Nonetheless, as momentous developments are reshaping the world, Sandia is also changing from its beginning as a closed operation concentrating on classified defense programs, Sandia has become a more accessible resource that focuses on research and development partnerships with industry and universities as a way to ensure continued success in DOE`s evolving core mission area of nuclear weapons, energy, environment, and the basis sciences. Through these collaborative efforts, Sandia and its partners are also benefiting the economic competitiveness of our nation. Sandia places a special emphasis on working with small businesses as both technology transfer partners and suppliers of goods and services. We are also reaching out the the larger community surrounding Sandia, striving to provide technological solution and accurate information to meet community needs. We believe that the dialogue we are creating will benefit Sandia, the community, and the nation. Our goal is to render `` exceptional service in the national interest`` by returning maximum value on the investment in the labs. As you review this document, look for new ways in which Sandia can contribute to the solution of problems facing our nation.

  1. Working Memory and Short-Term Memory Abilities in Accomplished Multilinguals

    ERIC Educational Resources Information Center

    Biedron, Adriana; Szczepaniak, Anna

    2012-01-01

    The role of short-term memory and working memory in accomplished multilinguals was investigated. Twenty-eight accomplished multilinguals were compared to 36 mainstream philology students. The following instruments were used in the study: three memory subtests of the Wechsler Intelligence Scale (Digit Span, Digit-Symbol Coding, and Arithmetic,…

  2. Summaries of 1984-85 NASA space-gravitational biology accomplishments

    NASA Technical Reports Server (NTRS)

    Halstead, T. W. (Compiler); Dutcher, F. R. (Compiler); Pleasant, L. G. (Compiler)

    1985-01-01

    Individual technical summaries of research projects of NASA's Space/Gravitational Biology Program are presented. The summaries for each project include a description of the research, a listing of the accomplishments, and an explanation of the significance of the accomplishments. Bibliographies for each project are also included.

  3. Materials Division research and technology accomplishments for FY 89 and plans for FY 90

    NASA Technical Reports Server (NTRS)

    Brinkley, Kay L.

    1990-01-01

    The research program of the Materials Division is presented as FY-89 accomplishments and FY-90 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material will be useful in program coordination with other government organizations, universities, and industries in areas of mutual interest.

  4. Materials Division research and technical accomplishments for FY 1988 and plans for FY 1989

    NASA Technical Reports Server (NTRS)

    Brinkley, Kay L.

    1989-01-01

    The research program of the Materials Division is presented as FY-88 accomplishments and FY-89 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material is useful in program coordination with other government organizations, universities, and industry in areas of mutual interest.

  5. The Role of Planned Professional Learning in Becoming an Accomplished Teacher: The Queensland Experience

    ERIC Educational Resources Information Center

    Saunders, Sherryl

    2009-01-01

    The role of planned professional learning in being an accomplished languages and cultures teacher has never been so important. Professional learning that focuses on "becoming" an accomplished practitioner as part of an ongoing professional learning experience rather than a process of detailing deficiencies is to be applauded. Indeed, the…

  6. Materials Division research and technology accomplishments for FY 87 and plans for FY 88

    NASA Technical Reports Server (NTRS)

    Brinkley, Kay L.

    1988-01-01

    The research program of the Materials Division is presented as FY 87 accomplishments and FY 88 plans. The accomplishments for each Branch are highlighted and plans are outlined. Publications of the Division are included by Branch. This material will be useful in program coordination with other government organizations, universities, and industries in areas of mutual interest.

  7. Predicting College Student Success: A Historical and Predictive Examination of High School Activities and Accomplishments

    ERIC Educational Resources Information Center

    Davey, Carla Mae

    2010-01-01

    According to generational theorists, the interests and experiences of incoming students have fluctuated over time, with Millennial students being more engaged and accomplished than their predecessors. This project explored data from 1974-2007 to determine the actual trends in engagement and accomplishments for three generations of students. Over…

  8. Teachers' Desire for Career-Long Learning: Becoming "Accomplished"--And Masterly…

    ERIC Educational Resources Information Center

    Watson, Cate; Drew, Valerie

    2015-01-01

    The "accomplished teacher" has emerged in educational policy as a term designed to capture the dispositions and skills of highly practised professionals. As such accomplishment is enacted within a current policy discourse of life-long, or career-long, professional learning which is concerned with continual self-development. This paper…

  9. REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

    SciTech Connect

    Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry; Carroll, Sean; Ooguri, Hirosi; Gukov, Sergei; Preskill, John; Hitlin, David G.; Porter, Frank C.; Patterson, Ryan B.; Newman, Harvey B.; Spiropulu, Maria; Golwala, Sunil; Zhu, Ren-Yuan

    2014-08-26

    of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these

  10. Transformation and Alignment in Similarity

    ERIC Educational Resources Information Center

    Hodgetts, Carl J.; Hahn, Ulrike; Chater, Nick

    2009-01-01

    This paper contrasts two structural accounts of psychological similarity: structural alignment (SA) and Representational Distortion (RD). SA proposes that similarity is determined by how readily the structures of two objects can be brought into alignment; RD measures similarity by the complexity of the transformation that "distorts" one…

  11. Acoustic Similarity and Dichotic Listening.

    ERIC Educational Resources Information Center

    Benson, Peter

    1978-01-01

    An experiment tests conjectures that right ear advantage (REA) has an auditory origin in competition or interference between acoustically similar stimuli and that feature-sharing effect (FSE) has its origin in assignment of features of phonetically similar stimuli. No effect on the REA for acoustic similarity, and a clear effect of acoustic…

  12. Mission accomplished

    SciTech Connect

    Rhinelander, J.B.; Rubin, J.P.

    1987-09-01

    In October 1085, then Security Adviser Robert McFarlane revealed the Reagan administration's new interpretation of the 1972 ABM Treaty, namely: develop and test Star Wars up to the point of deployment. This announcement led to storms of protest from NATO allies, members of Congress, and the Soviet Union. Congressional debate over the last two years, led by Senator Sam Nunn, demonstrated conclusively that when the Senate, by a vote of 88-2, gave its advice and consent to ratification in 1972, it did so on the basis of the traditional interpretation. The Reagan administration rested their case for the new interpretation primarily on their review of the treaty's negotiating record. One of the authors of this article (Rhinelander) was a legal adviser to the SALT I delegation. He and Rubin recently examined declassified portions of the negotiating record. Their findings are explicated here, with the conclusion reinforcing what all negotiators except Paul Nitze have said, namely: the traditional interpretation is irrefutably the one negotiated and agreed upon by both parties in 1972. They find the administration position extremely puzzling since the reinterpretation is not even necessary to continue a robust SDI program, which Nunn and other congressional leaders support.

  13. Program Accomplishments

    SciTech Connect

    none,

    2011-10-01

    The U.S. Department of Energy's (DOE's) efforts have greatly advanced the state of the art of hydrogen and fuel cell technologies—making significant progress toward overcoming many of the key challenges to widespread commercialization. DOE has also made major advances by demonstrating and validating the technologies under real-world conditions, supporting early markets through Recovery Act deployments, and leveraging domestic and international partnerships to advance the pace of commercialization.

  14. Phylogenetically related and ecologically similar carnivores harbour similar parasite assemblages.

    PubMed

    Huang, Shan; Bininda-Emonds, Olaf R P; Stephens, Patrick R; Gittleman, John L; Altizer, Sonia

    2014-05-01

    Most parasites infect multiple hosts, but what factors determine the range of hosts a given parasite can infect? Understanding the broad scale determinants of parasite distributions across host lineages is important for predicting pathogen emergence in new hosts and for estimating pathogen diversity in understudied host species. In this study, we used a new data set on 793 parasite species reported from free-ranging populations of 64 carnivore species to examine the factors that influence parasite sharing between host species. Our results showed that parasites are more commonly shared between phylogenetically related host species pairs. Additionally, host species with higher similarity in biological traits and greater geographic range overlap were also more likely to share parasite species. Of three measures of phylogenetic relatedness considered here, the number divergence events that separated host species pairs most strongly influenced the likelihood of parasite sharing. We also showed that viruses and helminths tend to infect carnivore hosts within more restricted phylogenetic ranges than expected by chance. Overall, our results underscore the importance of host evolutionary history in determining parasite host range, even when simultaneously considering other factors such as host ecology and geographic distribution.

  15. Dynamic similarity in erosional processes

    USGS Publications Warehouse

    Scheidegger, A.E.

    1963-01-01

    A study is made of the dynamic similarity conditions obtaining in a variety of erosional processes. The pertinent equations for each type of process are written in dimensionless form; the similarity conditions can then easily be deduced. The processes treated are: raindrop action, slope evolution and river erosion. ?? 1963 Istituto Geofisico Italiano.

  16. Discuss Similarity Using Visual Intuition

    ERIC Educational Resources Information Center

    Cox, Dana C.; Lo, Jane-Jane

    2012-01-01

    The change in size from a smaller shape to a larger similar shape (or vice versa) is created through continuous proportional stretching or shrinking in every direction. Students cannot solve similarity tasks simply by iterating or partitioning a composed unit, strategies typically used on numerical proportional tasks. The transition to thinking…

  17. Noncontiguous atom matching structural similarity function.

    PubMed

    Teixeira, Ana L; Falcao, Andre O

    2013-10-28

    Measuring similarity between molecules is a fundamental problem in cheminformatics. Given that similar molecules tend to have similar physical, chemical, and biological properties, the notion of molecular similarity plays an important role in the exploration of molecular data sets, query-retrieval in molecular databases, and in structure-property/activity modeling. Various methods to define structural similarity between molecules are available in the literature, but so far none has been used with consistent and reliable results for all situations. We propose a new similarity method based on atom alignment for the analysis of structural similarity between molecules. This method is based on the comparison of the bonding profiles of atoms on comparable molecules, including features that are seldom found in other structural or graph matching approaches like chirality or double bond stereoisomerism. The similarity measure is then defined on the annotated molecular graph, based on an iterative directed graph similarity procedure and optimal atom alignment between atoms using a pairwise matching algorithm. With the proposed approach the similarities detected are more intuitively understood because similar atoms in the molecules are explicitly shown. This noncontiguous atom matching structural similarity method (NAMS) was tested and compared with one of the most widely used similarity methods (fingerprint-based similarity) using three difficult data sets with different characteristics. Despite having a higher computational cost, the method performed well being able to distinguish either different or very similar hydrocarbons that were indistinguishable using a fingerprint-based approach. NAMS also verified the similarity principle using a data set of structurally similar steroids with differences in the binding affinity to the corticosteroid binding globulin receptor by showing that pairs of steroids with a high degree of similarity (>80%) tend to have smaller differences

  18. What Has the Federal Renewable Fuels Standard Accomplished - A National Perspective (Presentation)

    SciTech Connect

    Schwab, A.

    2013-04-01

    This presentation provides an overview of the nation's biofuels industry accomplishments and a perspective on the challenges and implications of reaching goals set in the Renewable Fuel Standard (RFS).

  19. The genetics of music accomplishment: evidence for gene-environment correlation and interaction.

    PubMed

    Hambrick, David Z; Tucker-Drob, Elliot M

    2015-02-01

    Theories of skilled performance that emphasize training history, such as K. Anders Ericsson and colleagues' deliberate-practice theory, have received a great deal of recent attention in both the scientific literature and the popular press. Twin studies, however, have demonstrated evidence for moderate-to-strong genetic influences on skilled performance. Focusing on musical accomplishment in a sample of over 800 pairs of twins, we found evidence for gene-environment correlation, in the form of a genetic effect on music practice. However, only about one quarter of the genetic effect on music accomplishment was explained by this genetic effect on music practice, suggesting that genetically influenced factors other than practice contribute to individual differences in music accomplishment. We also found evidence for gene-environment interaction, such that genetic effects on music accomplishment were most pronounced among those engaging in music practice, suggesting that genetic potentials for skilled performance are most fully expressed and fostered by practice.

  20. Reshaping American Energy - A Look Back at BETO's Accomplishments in 2013

    SciTech Connect

    2013-11-01

    For more than a decade, BETO has been shaping the bioenergy industry. BETO helps transform the nation's renewable biomass resources into high-performance biofuels, biopower, and bioproducts. This fact sheet outlines some of our biggest accomplishments in 2013.

  1. The genetics of music accomplishment: evidence for gene-environment correlation and interaction.

    PubMed

    Hambrick, David Z; Tucker-Drob, Elliot M

    2015-02-01

    Theories of skilled performance that emphasize training history, such as K. Anders Ericsson and colleagues' deliberate-practice theory, have received a great deal of recent attention in both the scientific literature and the popular press. Twin studies, however, have demonstrated evidence for moderate-to-strong genetic influences on skilled performance. Focusing on musical accomplishment in a sample of over 800 pairs of twins, we found evidence for gene-environment correlation, in the form of a genetic effect on music practice. However, only about one quarter of the genetic effect on music accomplishment was explained by this genetic effect on music practice, suggesting that genetically influenced factors other than practice contribute to individual differences in music accomplishment. We also found evidence for gene-environment interaction, such that genetic effects on music accomplishment were most pronounced among those engaging in music practice, suggesting that genetic potentials for skilled performance are most fully expressed and fostered by practice. PMID:24957535

  2. WISM - A Wideband Instrument for Snow Measurement: Past Accomplishments, Current Status, and Path Forward

    NASA Technical Reports Server (NTRS)

    Bonds, Quenton; Racette, Paul; Durham, Tim (Principal Investigator)

    2016-01-01

    Presented are the prior accomplishments, current status and path forward for GSFC's Wideband Instrument for Snow Measurement (WISM). This work is a high level overview of the project, presented via Webinar to the IEEE young professionals.

  3. NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY - AN ANNUAL REPORT OF ACCOMPLISHMENTS FOR FISCAL YEAR 2000

    EPA Science Inventory

    This Annual Report showcases some of the research activities of the National Health and Environmental Effects Research Laboratory (NHEERL) in various health and environmental effects research areas. The report is an indicator of the examples of progress and accomplishments that ...

  4. Some Effects of Similarity Self-Disclosure

    ERIC Educational Resources Information Center

    Murphy, Kevin C.; Strong, Stanley R.

    1972-01-01

    College males were interviewed about how college had altered their friendships, values, and plans. The interviewers diclosed experiences and feelings similar to those revealed by the students. Results support Byrne's Law of Similarity in generating interpersonal attraction in the interview and suggest that the timing of self-disclosures is…

  5. Quality management at Argonne National Laboratory: Status, accomplishments, and lessons learned

    SciTech Connect

    1995-06-01

    In April 1992, Argonne National Laboratory (ANL) launched the implementation of quality management (QM) as an initiative of the Laboratory Director. The goal of the program is to seek ways of improving Laboratory performance and effectiveness by drawing from the realm of experiences in the global total quality management movement. The Argonne QM initiative began with fact finding and formulating a strategy for implementation; the emphasis is that the underlying principles of QM should be an integral part of how the Laboratory is managed and operated. A primary theme that has guided the Argonne QM initiative is to consider only those practices that offer the potential for real improvement, make sense, fit the culture, and would be credible to the broad population. In October 1993, the Laboratory began to pilot a targeted set of QM activities selected to produce outcomes important to the Laboratory--strengthening the customer focus, improving work processes, enhancing employee involvement and satisfaction, and institutionalizing QM. This report describes the results of the just-concluded QM development and demonstration phase in terms of detailed strategies, accomplishments, and lessons learned. These results are offered as evidence to support the conclusion that the Argonne QM initiative has achieved value-added results and credibility and is well positioned to support future deployment across the entire Laboratory as an integrated management initiative. Recommendations for follow-on actions to implement future deployment are provided separately.

  6. Structural dynamics division research and technology accomplishments for FY 1993 and plans for FY 1994

    NASA Technical Reports Server (NTRS)

    Wynne, Eleanor C.

    1994-01-01

    The purpose is to present the Structural Dynamics Division's research accomplishments for F.Y. 1993 and research plans for F.Y. 1994. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5-year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  7. Loads and Aeroelasticity Division research and technology accomplishments for FY 1986 and plans for FY 1987

    NASA Technical Reports Server (NTRS)

    Gardner, James E.; Dixon, S. C.

    1987-01-01

    The Loads and Aeroelasticity Division's research accomplishments for FY 86 and research plans for FY 87 are presented. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  8. Loads and aeroelasticity division research and technology accomplishments for FY 1985 and plans for FY 1986

    NASA Technical Reports Server (NTRS)

    Gardner, J. E.; Dixon, S. C.

    1986-01-01

    The Langley Research Center Loads and Aeroelasticity Division's research accomplishments for FY85 and research plans for FY86 are presented. The rk under each branch (technical area) will be described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  9. Loads and Aeroelasticity Division research and technology accomplishments for FY 1984 and plans for FY 1985

    NASA Technical Reports Server (NTRS)

    Gardner, J. E.; Dixon, S. C.

    1985-01-01

    The loads and aeroelasticity divisions research accomplishments are presented. The work under each branch or technical area, described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5 year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  10. Structural dynamics division research and technology accomplishments for FY 1989 and plans for FY 1990

    NASA Technical Reports Server (NTRS)

    Smith, Jacqueline G.; Gardner, James E.

    1990-01-01

    The purpose is to present the Structural Dynamics Division's research accomplishments for FY 1989 and research plans for FY 1990. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  11. Structural dynamics division research and technology accomplishments for FY 1988 and plans for FY 1989

    NASA Technical Reports Server (NTRS)

    Gardner, James E.

    1989-01-01

    The purpose of this paper is to present the Structural Dynamics Division's research accomplishments for FY 1988 and research plans for FY 1989. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and plans for the current year as they relate to five-year plans for each area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  12. Loads and aeroelasticity division research and technology accomplishments for FY 1987 and plans for FY 1988

    NASA Technical Reports Server (NTRS)

    Dixon, S. C.; Gardner, James E.

    1988-01-01

    The purpose of this paper is to present the Loads and Aeroelasticity Division's research accomplishments for FY87 and research plans for FY88. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  13. Self-similar aftershock rates

    NASA Astrophysics Data System (ADS)

    Davidsen, Jörn; Baiesi, Marco

    2016-08-01

    In many important systems exhibiting crackling noise—an intermittent avalanchelike relaxation response with power-law and, thus, self-similar distributed event sizes—the "laws" for the rate of activity after large events are not consistent with the overall self-similar behavior expected on theoretical grounds. This is particularly true for the case of seismicity, and a satisfying solution to this paradox has remained outstanding. Here, we propose a generalized description of the aftershock rates which is both self-similar and consistent with all other known self-similar features. Comparing our theoretical predictions with high-resolution earthquake data from Southern California we find excellent agreement, providing particularly clear evidence for a unified description of aftershocks and foreshocks. This may offer an improved framework for time-dependent seismic hazard assessment and earthquake forecasting.

  14. Self-similar aftershock rates.

    PubMed

    Davidsen, Jörn; Baiesi, Marco

    2016-08-01

    In many important systems exhibiting crackling noise-an intermittent avalanchelike relaxation response with power-law and, thus, self-similar distributed event sizes-the "laws" for the rate of activity after large events are not consistent with the overall self-similar behavior expected on theoretical grounds. This is particularly true for the case of seismicity, and a satisfying solution to this paradox has remained outstanding. Here, we propose a generalized description of the aftershock rates which is both self-similar and consistent with all other known self-similar features. Comparing our theoretical predictions with high-resolution earthquake data from Southern California we find excellent agreement, providing particularly clear evidence for a unified description of aftershocks and foreshocks. This may offer an improved framework for time-dependent seismic hazard assessment and earthquake forecasting. PMID:27627324

  15. Self-similar aftershock rates.

    PubMed

    Davidsen, Jörn; Baiesi, Marco

    2016-08-01

    In many important systems exhibiting crackling noise-an intermittent avalanchelike relaxation response with power-law and, thus, self-similar distributed event sizes-the "laws" for the rate of activity after large events are not consistent with the overall self-similar behavior expected on theoretical grounds. This is particularly true for the case of seismicity, and a satisfying solution to this paradox has remained outstanding. Here, we propose a generalized description of the aftershock rates which is both self-similar and consistent with all other known self-similar features. Comparing our theoretical predictions with high-resolution earthquake data from Southern California we find excellent agreement, providing particularly clear evidence for a unified description of aftershocks and foreshocks. This may offer an improved framework for time-dependent seismic hazard assessment and earthquake forecasting.

  16. Activity-relevant similarity values for fingerprints and implications for similarity searching

    PubMed Central

    Jasial, Swarit; Hu, Ye; Vogt, Martin; Bajorath, Jürgen

    2016-01-01

    A largely unsolved problem in chemoinformatics is the issue of how calculated compound similarity relates to activity similarity, which is central to many applications. In general, activity relationships are predicted from calculated similarity values. However, there is no solid scientific foundation to bridge between calculated molecular and observed activity similarity. Accordingly, the success rate of identifying new active compounds by similarity searching is limited. Although various attempts have been made to establish relationships between calculated fingerprint similarity values and biological activities, none of these has yielded generally applicable rules for similarity searching. In this study, we have addressed the question of molecular versus activity similarity in a more fundamental way. First, we have evaluated if activity-relevant similarity value ranges could in principle be identified for standard fingerprints and distinguished from similarity resulting from random compound comparisons. Then, we have analyzed if activity-relevant similarity values could be used to guide typical similarity search calculations aiming to identify active compounds in databases. It was found that activity-relevant similarity values can be identified as a characteristic feature of fingerprints. However, it was also shown that such values cannot be reliably used as thresholds for practical similarity search calculations. In addition, the analysis presented herein helped to rationalize differences in fingerprint search performance. PMID:27127620

  17. Quantifying Similarity in Seismic Polarizations

    NASA Astrophysics Data System (ADS)

    Eaton, D. W. S.; Jones, J. P.; Caffagni, E.

    2015-12-01

    Measuring similarity in seismic attributes can help identify tremor, low S/N signals, and converted or reflected phases, in addition to diagnosing site noise and sensor misalignment in arrays. Polarization analysis is a widely accepted method for studying the orientation and directional characteristics of seismic phases via. computed attributes, but similarity is ordinarily discussed using qualitative comparisons with reference values. Here we introduce a technique for quantitative polarization similarity that uses weighted histograms computed in short, overlapping time windows, drawing on methods adapted from the image processing and computer vision literature. Our method accounts for ambiguity in azimuth and incidence angle and variations in signal-to-noise (S/N) ratio. Using records of the Mw=8.3 Sea of Okhotsk earthquake from CNSN broadband sensors in British Columbia and Yukon Territory, Canada, and vertical borehole array data from a monitoring experiment at Hoadley gas field, central Alberta, Canada, we demonstrate that our method is robust to station spacing. Discrete wavelet analysis extends polarization similarity to the time-frequency domain in a straightforward way. Because histogram distance metrics are bounded by [0 1], clustering allows empirical time-frequency separation of seismic phase arrivals on single-station three-component records. Array processing for automatic seismic phase classification may be possible using subspace clustering of polarization similarity, but efficient algorithms are required to reduce the dimensionality.

  18. Sibling similarity in family formation.

    PubMed

    Raab, Marcel; Fasang, Anette Eva; Karhula, Aleksi; Erola, Jani

    2014-12-01

    Sibling studies have been widely used to analyze the impact of family background on socioeconomic and, to a lesser extent, demographic outcomes. We contribute to this literature with a novel research design that combines sibling comparisons and sequence analysis to analyze longitudinal family-formation trajectories of siblings and unrelated persons. This allows us to scrutinize in a more rigorous way whether sibling similarity exists in family-formation trajectories and whether siblings' shared background characteristics, such as parental education and early childhood family structure, can account for similarity in family formation. We use Finnish register data from 1987 through 2007 to construct longitudinal family-formation trajectories in young adulthood for siblings and unrelated dyads (N = 14,257 dyads). Findings show that family formation is moderately but significantly more similar for siblings than for unrelated dyads, also after controlling for crucial parental background characteristics. Shared parental background characteristics add surprisingly little to account for sibling similarity in family formation. Instead, gender and the respondents' own education are more decisive forces in the stratification of family formation. Yet, family internal dynamics seem to reinforce this stratification such that siblings have a higher probability to experience similar family-formation patterns. In particular, patterns that correspond with economic disadvantage are concentrated within families. This is in line with a growing body of research highlighting the importance of family structure in the reproduction of social inequality.

  19. Two perspectives on similarity between words

    NASA Astrophysics Data System (ADS)

    Frisch, Stefan A.

    2003-10-01

    This presentation examines the similarity between words from both bottom up (phonetic) and top down (phonological/psycholinguistic) perspectives. From the phonological perspective, the influence of structure on similarity is explored using metalinguistic acceptability judgments for multisyllabic nonwords. Results from an experiment suggest that subjects try to align novel words with known words in order to maximize similarities while minimizing dissimilarities. This finding parallels results from psychology on similarity judgments for visual scenes. From the phonetic perspective, the influence of similar gestures on speech error rates is examined using ultrasound measurement of tongue position. In a pilot experiment, subjects, produced tongue twisters containing words where onset and vowel phonemes had similar gestures (e.g., tip, comb) and where the onset and vowel had dissimilar gestures (e.g., tube, keep). Preliminary results suggest that misarticulations are more frequent in the context of dissimilar gestures (e.g., in the tongue twister tip cape keep tape, error rates are higher for /k/ than /t/). These errors appear to be gestural interactions rather than errors at the phonemic or featural level of phonological spellout. Together, these two experiments indicate that similarity relations between words are found at multiple levels, any which are potentially relevant to the structure of phonological systems.

  20. Similarity in drugs: reflections on analogue design.

    PubMed

    Wermuth, Camille G

    2006-04-01

    A survey of novel small-molecule therapeutics reveals that the majority of them result from analogue design and that their market value represents two-thirds of all small-molecule sales. In natural science, the term analogue, derived from the Latin and Greek analogia, has always been used to describe structural and functional similarity. Extended to drugs, this definition implies that the analogue of an existing drug molecule shares structural and pharmacological similarities with the original compound. Formally, this definition allows the establishment of three categories of drug analogues: analogues possessing chemical and pharmacological similarities (direct analogues); analogues possessing structural similarities only (structural analogues); and chemically different compounds displaying similar pharmacological properties (functional analogues). PMID:16580977

  1. Transformation and alignment in similarity.

    PubMed

    Hodgetts, Carl J; Hahn, Ulrike; Chater, Nick

    2009-10-01

    This paper contrasts two structural accounts of psychological similarity: structural alignment (SA) and Representational Distortion (RD). SA proposes that similarity is determined by how readily the structures of two objects can be brought into alignment; RD measures similarity by the complexity of the transformation that "distorts" one representation into the other. We assess RD by defining a simple coding scheme of psychological transformations for the experimental materials. In two experiments, this "concrete" version of RD provides compelling fits of the data and compares favourably with SA. Finally, stepping back from particular models, we argue that perceptual theory suggests that transformations and alignment processes should generally be viewed as complementary, in contrast to the current distinction in the literature. PMID:19720370

  2. The contribution of the ACCOMPLISH trial to the treatment of stage 2 hypertension.

    PubMed

    Byrd, James Brian; Bakris, George; Jamerson, Kenneth

    2014-03-01

    The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommended a thiazide-like diuretic, alone or in combination with other antihypertensive drug classes, as initial therapy for hypertension. JNC 7, however, did not specify preferred combinations. The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial was completed five years after the JNC 7 and demonstrated a 20 % advantage in cardiovascular risk reduction when blood pressure was lowered using the single-pill combination of benazepril-amlodipine compared to benazepril-hydrochlorothiazide (Jamerson et al. 359(23):2417-28 [1]). This new and significant finding provided compelling evidence that the long-standing preference for diuretics as initial therapy could be refuted, but it may also be relevant to the lower-than-expected reduction in coronary disease related events (compared to stroke) observed for decades prior to the ACCOMPLISH approach to therapy. The JNC 8 panel members recently published their recommendations, and while the group did not recommend benazepril-hydrochlorothiazide over other combinations, they did highlight the findings of ACCOMPLISH, rating the primary ACCOMPLISH paper as "good." The American Society of Hypertension position paper and the European Hypertension Society guidelines endorse such combinations as a first-line agent for patients with stage 2 hypertension. We review the current position of ACCOMPLISH in the guidelines regarding treatment of stage 2 hypertension. PMID:24474031

  3. Stability of similarity measurements for bipartite networks

    PubMed Central

    Liu, Jian-Guo; Hou, Lei; Pan, Xue; Guo, Qiang; Zhou, Tao

    2016-01-01

    Similarity is a fundamental measure in network analyses and machine learning algorithms, with wide applications ranging from personalized recommendation to socio-economic dynamics. We argue that an effective similarity measurement should guarantee the stability even under some information loss. With six bipartite networks, we investigate the stabilities of fifteen similarity measurements by comparing the similarity matrixes of two data samples which are randomly divided from original data sets. Results show that, the fifteen measurements can be well classified into three clusters according to their stabilities, and measurements in the same cluster have similar mathematical definitions. In addition, we develop a top-n-stability method for personalized recommendation, and find that the unstable similarities would recommend false information to users, and the performance of recommendation would be largely improved by using stable similarity measurements. This work provides a novel dimension to analyze and evaluate similarity measurements, which can further find applications in link prediction, personalized recommendation, clustering algorithms, community detection and so on. PMID:26725688

  4. Comparison of hydrological similarity measures

    NASA Astrophysics Data System (ADS)

    Rianna, Maura; Ridolfi, Elena; Manciola, Piergiorgio; Napolitano, Francesco; Russo, Fabio

    2016-04-01

    The use of a traditional at site approach for the statistical characterization and simulation of spatio-temporal precipitation fields has a major recognized drawback. Indeed, the weakness of the methodology is related to the estimation of rare events and it involves the uncertainty of the at-site sample statistical inference, because of the limited length of records. In order to overcome the lack of at-site observations, regional frequency approach uses the idea of substituting space for time to estimate design floods. The conventional regional frequency analysis estimates quantile values at a specific site from multi-site analysis. The main idea is that homogeneous sites, once pooled together, have similar probability distribution curves of extremes, except for a scaling factor. The method for pooling groups of sites can be based on geographical or climatological considerations. In this work the region of influence (ROI) pooling method is compared with an entropy-based one. The ROI is a flexible pooling group approach which defines for each site its own "region" formed by a unique set of similar stations. The similarity is found through the Euclidean distance metric in the attribute space. Here an alternative approach based on entropy is introduced to cluster homogeneous sites. The core idea is that homogeneous sites share a redundant (i.e. similar) amount of information. Homogeneous sites are pooled through a hierarchical selection based on the mutual information index (i.e. a measure of redundancy). The method is tested on precipitation data in Central Italy area.

  5. What Difference Reveals about Similarity

    ERIC Educational Resources Information Center

    Sagi, Eyal; Gentner, Dedre; Lovett, Andrew

    2012-01-01

    Detecting that two images are different is faster for highly dissimilar images than for highly similar images. Paradoxically, we showed that the reverse occurs when people are asked to describe "how" two images differ--that is, to state a difference between two images. Following structure-mapping theory, we propose that this disassociation arises…

  6. A Similarity Search Using Molecular Topological Graphs

    PubMed Central

    Fukunishi, Yoshifumi; Nakamura, Haruki

    2009-01-01

    A molecular similarity measure has been developed using molecular topological graphs and atomic partial charges. Two kinds of topological graphs were used. One is the ordinary adjacency matrix and the other is a matrix which represents the minimum path length between two atoms of the molecule. The ordinary adjacency matrix is suitable to compare the local structures of molecules such as functional groups, and the other matrix is suitable to compare the global structures of molecules. The combination of these two matrices gave a similarity measure. This method was applied to in silico drug screening, and the results showed that it was effective as a similarity measure. PMID:20037730

  7. What causes similarity in catchments?

    NASA Astrophysics Data System (ADS)

    Savenije, Hubert

    2014-05-01

    One of the biggest issues in hydrology is how to handle the heterogeneity of catchment properties at different scales. But is this really such a big issue? Is this problem not merely the consequence of how we conceptualise and how we model catchments? Is there not far more similarity than we observe. Maybe we are not looking at the right things or at the right scale to see the similarity. The identity of catchments is largely determined by: the landscape, the ecosystem living on the landscape, and the geology, in that order. Soils, which are often seen as a crucial aspect of hydrological behaviour, are far less important, as will be demonstrated. The main determinants of hydrological behaviour are: the landscape composition, the rooting depth and the phenology. These determinants are a consequence of landscape and ecosystem evolution, which, in turn, are the manifestations of entropy production. There are striking similarities between catchments. The different runoff processes from hillslopes are linked and similar in different environments (McDonnell, 2013). Wetlands behave similarly all over the world. The key is to classify landscapes and to link the ecosystems living on them to climate. The ecosystem then is the main controller of hydrological behaviour. Besides phenology, the rooting depth is key in determining runoff behaviour. Both are strongly linked to climate and much less to soil properties. An example is given of how rooting depth is determined by climate, and how rooting depth can be predicted without calibration, providing a strong constraints on the prediction of rainfall partitioning and catchment runoff.

  8. Satellite clock corrections estimation to accomplish real time ppp: experiments for brazilian real time network

    NASA Astrophysics Data System (ADS)

    Marques, Haroldo; Monico, João; Aquino, Marcio; Melo, Weyller

    2014-05-01

    applied in the Real Time PPP for Brazilian network stations and also for flight test of the Brazilian airplanes and the results show that it is possible to accomplish real time PPP in the static and kinematic modes with accuracy of the order of 10 to 20 cm, respectively.

  9. Structural dynamics division research and technology accomplishments for FY 1992 and plans for FY 1993

    NASA Technical Reports Server (NTRS)

    Wynne, Eleanor C.

    1993-01-01

    The purpose of this paper is to present the Structural Dynamics Division's research accomplishments for F.Y. 1992 and research plans for F.Y. 1993. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5-year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

  10. Innovative Partnerships Program Accomplishments: 2009-2010 at NASA's Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Makufka, David

    2010-01-01

    This document reports on the accomplishments of the Innovative Partnerships Program during the two years of 2009 and 2010. The mission of the Innovative Partnerships Program is to provide leveraged technology alternatives for mission directorates, programs, and projects through joint partnerships with industry, academia, government agencies, and national laboratories. As outlined in this accomplishments summary, the IPP at NASA's Kennedy Space Center achieves this mission via two interdependent goals: (1) Infusion: Bringing external technologies and expertise into Kennedy to benefit NASA missions, programs, and projects (2) Technology Transfer: Spinning out space program technologies to increase the benefits for the nation's economy and humanity

  11. Structural mechanics division research and technology accomplishments for CY 1992 and plans for CY 1993

    NASA Technical Reports Server (NTRS)

    Malone, John B.

    1993-01-01

    The purpose of this report is to present the Structural Mechanics Division's research accomplishments for C.Y. 1992 and plans for C.Y. 1993. The technical mission and goals of the division and its constituent research branches are described. The work under each branch is described in terms of highlights of accomplishments during the past year and plans for the current year as they relate to branch long range goals. This information is useful in program coordination with other government organizations, universities, and industry in areas of mutual interest.

  12. Electrochemical healing similarities between animals and plants.

    PubMed Central

    Gensler, W

    1979-01-01

    A brief summary of the major results in enhanced wound healing by electrolysis in animals and humans is presented along with the results of enhanced growth by electrolysis in plants. Hypotheses of normal and enhanced wound healing in animal and plants are reviewed. A comparison of the experimental results indicates strong similarities in the optimum magnitude and polarity of the externally applied galvanic current in animals and plants. There are, however, differences in optimum current densities, There are strong similarities in animal and plant electropotential changes during normal healing. Images FIGURE 1 PMID:262440

  13. Active browsing using similarity pyramids

    NASA Astrophysics Data System (ADS)

    Chen, Jau-Yuen; Bouman, Charles A.; Dalton, John C.

    1998-12-01

    In this paper, we describe a new approach to managing large image databases, which we call active browsing. Active browsing integrates relevance feedback into the browsing environment, so that users can modify the database's organization to suit the desired task. Our method is based on a similarity pyramid data structure, which hierarchically organizes the database, so that it can be efficiently browsed. At coarse levels, the similarity pyramid allows users to view the database as large clusters of similar images. Alternatively, users can 'zoom into' finer levels to view individual images. We discuss relevance feedback for the browsing process, and argue that it is fundamentally different from relevance feedback for more traditional search-by-query tasks. We propose two fundamental operations for active browsing: pruning and reorganization. Both of these operations depend on a user-defined relevance set, which represents the image or set of images desired by the user. We present statistical methods for accurately pruning the database, and we propose a new 'worm hole' distance metric for reorganizing the database, so that members of the relevance set are grouped together.

  14. Gait Signal Analysis with Similarity Measure

    PubMed Central

    Shin, Seungsoo

    2014-01-01

    Human gait decision was carried out with the help of similarity measure design. Gait signal was selected through hardware implementation including all in one sensor, control unit, and notebook with connector. Each gait signal was considered as high dimensional data. Therefore, high dimensional data analysis was considered via heuristic technique such as the similarity measure. Each human pattern such as walking, sitting, standing, and stepping up was obtained through experiment. By the results of the analysis, we also identified the overlapped and nonoverlapped data relation, and similarity measure analysis was also illustrated, and comparison with conventional similarity measure was also carried out. Hence, nonoverlapped data similarity analysis provided the clue to solve the similarity of high dimensional data. Considered high dimensional data analysis was designed with consideration of neighborhood information. Proposed similarity measure was applied to identify the behavior patterns of different persons, and different behaviours of the same person. Obtained analysis can be extended to organize health monitoring system for specially elderly persons. PMID:25110724

  15. The baryonic self similarity of dark matter

    SciTech Connect

    Alard, C.

    2014-06-20

    The cosmological simulations indicates that dark matter halos have specific self-similar properties. However, the halo similarity is affected by the baryonic feedback. By using momentum-driven winds as a model to represent the baryon feedback, an equilibrium condition is derived which directly implies the emergence of a new type of similarity. The new self-similar solution has constant acceleration at a reference radius for both dark matter and baryons. This model receives strong support from the observations of galaxies. The new self-similar properties imply that the total acceleration at larger distances is scale-free, the transition between the dark matter and baryons dominated regime occurs at a constant acceleration, and the maximum amplitude of the velocity curve at larger distances is proportional to M {sup 1/4}. These results demonstrate that this self-similar model is consistent with the basics of modified Newtonian dynamics (MOND) phenomenology. In agreement with the observations, the coincidence between the self-similar model and MOND breaks at the scale of clusters of galaxies. Some numerical experiments show that the behavior of the density near the origin is closely approximated by a Einasto profile.

  16. Management Development Program. A Review of the Program's Goals and Accomplishments, 1980-1984. Internal Report.

    ERIC Educational Resources Information Center

    Cloud, Sherrill

    The goals and accomplishments of the Management Development Program, which was operated by the National Center for Higher Education Management System with funds from the National Institute of Education, are reported. Twenty-eight seminar/institute topics were developed from 1980 through 1983 to address planning-level issues of importance to…

  17. Reconstituting the ADHD Girl: Accomplishing Exclusion and Solidifying a Biomedical Identity in an ADHD Class

    ERIC Educational Resources Information Center

    Hjörne, Eva; Evaldsson, Ann-Carita

    2015-01-01

    In this study, we explore what happens to young people labelled as having attention deficit hyperactivity disorder (ADHD) after they have been excluded from mainstream class and placed in a special class. More specifically, we focus on how a specific disability identity is locally accomplished and ascribed to a girl placed in an ADHD class…

  18. Research and technology plans for FY 1989 and accomplishments for FY 1988. [Structural Mechanics Division

    SciTech Connect

    Bales, K.S.

    1989-04-01

    The Objectives, FY 1989 Plans, Approach, and FY 1989 Milestones for the Structural Mechanics Division's research programs are presented. Fiscal year 1988 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  19. Activities and Accomplishments in Various Domains: Relationships with Creative Personality and Creative Motivation in Adolescence

    ERIC Educational Resources Information Center

    Hong, Eunsook; Peng, Yun; O'Neil, Harold F., Jr.

    2014-01-01

    This study examined relationships between five personal traits and adolescents' creative activities and accomplishments in five domains--music, visual arts, creative writing, science, and technology. Participants were 439 tenth graders (220 males and 219 females) in China. The relationships were examined using confirmatory factor analysis.…

  20. Technical summary of accomplishments made in preparation for the USSR barley exploratory experiment

    NASA Technical Reports Server (NTRS)

    Chapman, G. M.; Dailey, C. L.

    1982-01-01

    The highlights of the work accomplished under each subcomponent of the U.S.S.R. Barley Pilot Experiment, which is scheduled for completion in 1984, are summarized. A significant amount of developmental system implementation activity was in the final stages of preparation prior to the rescoping of project tasks. Unpublished materials which are significant to this exploratory experiment are incorporated into the appendixes.

  1. Skylab experiments. Volume 6: Mechanics. [Skylab program accomplishments for high school level education

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Skylab program activities are presented in a form adapted to instruction of high school students. The overall goals of the program are discussed. The specific accomplishments of the mechanics investigations are described. The subjects involved are as follows: (1) evaluation of mobility aids, (2) mass measurement devices, and (3) space guidance crew/vehicle disturbances.

  2. Research and technology plans for FY 1989 and accomplishments for FY 1988. [Structural Mechanics Division

    NASA Technical Reports Server (NTRS)

    Bales, Kay S.

    1989-01-01

    The Objectives, FY 1989 Plans, Approach, and FY 1989 Milestones for the Structural Mechanics Division's research programs are presented. Fiscal year 1988 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  3. Structures and Dynamics Division research and technology plans for FY 1988 and accomplishments for FY 1987

    NASA Technical Reports Server (NTRS)

    Bales, Kay S.

    1988-01-01

    Presented are the Objectives, FY 1988 Plans, Approach, and FY 1988 Milestones for the Structures and Dynamics Division (Langley Research Center) research programs. FY 1987 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  4. Structural Mechanics Division research and technology plans for FY 1990 and accomplishments for FY 1989

    NASA Technical Reports Server (NTRS)

    Bales, Kay S.

    1990-01-01

    The Objectives, FY 1990 Plans, Approach, and FY 1990 Milestones for the Structural Mechanics Division's research programs are presented. FY 1989 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  5. Structures and Dynamics Division research and technology plans for FY 1985 and accomplishments for FY 1984

    NASA Technical Reports Server (NTRS)

    Bales, K. S.

    1985-01-01

    The objectives, FY 1985 plans, approach, and FY 1985 milestones for the Structures and Dynamics Division's research programs are presented. The FY 1984 accomplishments are presented where applicable. This information is useful in program coordination with other government organizations in areas of mutual interest.

  6. Accomplishing the Visions for Teacher Education Programs Advocated in the "National Science Education Standards"

    ERIC Educational Resources Information Center

    Akcay, Hakan; Yager, Robert

    2010-01-01

    The purpose of this study was to investigate the advantages of an approach to instruction using current problems and issues as curriculum organizers and illustrating how teaching must change to accomplish real learning. The study sample consisted of 41 preservice science teachers (13 males and 28 females) in a model science teacher education…

  7. Accountability and Accomplished Teaching: Researching the Chartered Teacher Programme in Scotland

    ERIC Educational Resources Information Center

    Hulme, Moira; Menter, Ian; McMahon, Margery

    2013-01-01

    The Scottish chartered teacher programme (2003-2011) is an important example of a national policy designed to support the development of "accomplished teaching". This paper provides an account of the emergence of the programme before discussing how the impact of such a scheme might be assessed and thus rendered accountable. The…

  8. Structures and Dynamics Division research and technology plans for FY 1986 and accomplishments for FY 1985

    NASA Technical Reports Server (NTRS)

    Bales, K. S.

    1986-01-01

    Presented are the Objectives, FY 1986 Plans, Approach, and FY 1986 Milestones for the Structures and Dynamics Division's research programs. FY 1985 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  9. The Accomplishments of Disabled Women's Advocacy Organizations and Their Future in Korea

    ERIC Educational Resources Information Center

    Kim, Kyung Mee

    2010-01-01

    Since the late 1990s disabled women's advocacy organizations have fought against oppression and have made great strides in Korea. This paper aims to describe the accomplishments, challenges and future directions of disabled women's advocacy organizations in Korea. A qualitative design was employed to explore disabled women's perspectives.…

  10. 41 CFR 102-42.125 - How is donation of gifts or decorations accomplished?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How is donation of gifts... 42-UTILIZATION, DONATION, AND DISPOSAL OF FOREIGN GIFTS AND DECORATIONS Donation of Foreign Gifts and Decorations § 102-42.125 How is donation of gifts or decorations accomplished? The State Agencies for...

  11. 41 CFR 102-42.125 - How is donation of gifts or decorations accomplished?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false How is donation of gifts... 42-UTILIZATION, DONATION, AND DISPOSAL OF FOREIGN GIFTS AND DECORATIONS Donation of Foreign Gifts and Decorations § 102-42.125 How is donation of gifts or decorations accomplished? The State Agencies for...

  12. Loads and aeroelasticity division research and technology accomplishments for FY 1982 and plans for FY 1983

    NASA Technical Reports Server (NTRS)

    Gardner, J. E.

    1983-01-01

    Accomplishments of the past year and plans for the coming year are highlighted as they relate to five year plans and the objectives of the following technical areas: aerothermal loads; multidisciplinary analysis and optimization; unsteady aerodynamics; and configuration aeroelasticity. Areas of interest include thermal protection system concepts, active control, nonlinear aeroelastic analysis, aircraft aeroelasticity, and rotorcraft aeroelasticity and vibrations.

  13. Cognitive-Behavioral Tasks Accomplished in a Person-Centered Relational Framework

    ERIC Educational Resources Information Center

    Tursi, Michael M.; Cochran, Jeff L.

    2006-01-01

    The authors propose a person-centered relational framework in which C. R. Rogers's (1957) core conditions remain the primary catalyst of therapeutic change and cognitive-behavioral work is accomplished while adhering to person-centered principles. Important ideas asserted include the following: Cognitive-behavioral tasks occur naturally within the…

  14. Foreign and Domestic Accomplishments in Magnetic Bubble Device Technology. Computer Science & Technology.

    ERIC Educational Resources Information Center

    Warnar, Robert B. J.; Calomeris, Peter J.

    This document assesses the status of magnetic bubble technology as displayed by non-U.S. research and manufacturing facilities. Non-U.S. research and U.S. accomplishments are described while both technical and economic factors are addressed. Magnetic bubble devices are discussed whenever their application could impact future computer system…

  15. Empowering Adult Learners. NIF Literacy Program Helps ABE Accomplish Human Development Mission.

    ERIC Educational Resources Information Center

    Hurley, Mary E.

    1991-01-01

    The National Issues Forum's Literacy Program uses study circles and group discussion to promote empowerment and enhance adult literacy through civic education. The program has helped the Westonka (Minnesota) Adult Basic Education project accomplish its mission and has expanded the staff's view of adult learning. (SK)

  16. Accomplishing Marginalization in Bilingual Interaction: Relational Work as a Resource for the Intersubjective Construction of Identity

    ERIC Educational Resources Information Center

    Cashman, Holly R.

    2008-01-01

    This paper examines the use of impoliteness by Spanish-English bilingual pre-adolescents as a resource for accomplishing identities in spontaneous conversational interactions in an elementary school setting. The theoretical approach employed integrates the concept of relational work (Locher 2004; Locher and Watts 2005), which is based on Goffman's…

  17. Definition and Measurement in the Affective Domain: Appreciation of Human Accomplishments.

    ERIC Educational Resources Information Center

    Campbell, Paul B.; Beers, Joan S.

    The first three levels of the taxonomy in the affective domain guided the development of two inventories--the Pennsylvania Inventory of Cultural Appreciations (PICA) for 11th graders and Things People Do (TPD) for 5th graders--to measure appreciation of human accomplishments in seven areas: politics, sciences, sports, literature, visual arts,…

  18. Structures and Dynamics Division research and technology plans for FY 1987 and accomplishments for FY 1986

    NASA Technical Reports Server (NTRS)

    Bales, Kay S.

    1987-01-01

    This paper presents the Objectives, FY 1987 Plans, Approach, and FY 1987 Milestones for the Structures and Dynamics Division's research programs. FY 1986 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

  19. DOE-NREL Minority University Research Associates Program FY 2005 Accomplishments

    SciTech Connect

    Eddy, F. P.

    2005-11-01

    The DOE-NREL Minority University Research Associates (MURA) Program encourages minority students to pursue careers in science and technology. In 2003, eight minority-serving institutions were awarded 3-year subcontracts that began in the summer/fall of FY 2004. This paper lists accomplishments made in the project's first phase.

  20. ERIC Annual Report-1988. Summarizing the Accomplishments of the Educational Resources Information Center.

    ERIC Educational Resources Information Center

    Krekeler, Nancy A.; Stonehill, Robert M.; Thomas, Robert L.

    This is the second in a series of annual reports summarizing the activities and accomplishments of the Educational Resources Information Center (ERIC) program, which is funded and managed by the Office of Educational Resources and Improvement in the U.S. Department of Education. The report begins by presenting background information on ERIC's…

  1. Assembling the "Accomplished" Teacher: The Performativity and Politics of Professional Teaching Standards

    ERIC Educational Resources Information Center

    Mulcahy, Dianne

    2011-01-01

    Set within the socio-political context of standards-based education reform, this article explores the constitutive role of teaching standards in the production of the practice and identity of the "accomplished" teacher. It contrasts two idioms for thinking about and studying these standards, the representational and the performative. Utilising the…

  2. Choosing Communication Portfolios to Accomplish Tasks: The Effects of Individual Differences

    ERIC Educational Resources Information Center

    Lee, Chei Sian; Goh, Dion Hoe-Lian; Chua, Alton Y. K; Luyt, Brendan

    2009-01-01

    The myriad of information communication technologies (ICTs) available today has changed the way students choose and use them. Specifically, individuals are increasingly relying on a mix of ICTs for communication to accomplish tasks. Yet, past studies on ICT use has largely assumed that people use a single ICT per task. We attempt to address this…

  3. 30 CFR 250.1714 - What must I accomplish with well plugs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I accomplish with well plugs? 250.1714 Section 250.1714 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT... ensure that all well plugs: (a) Provide downhole isolation of hydrocarbon and sulphur zones; (b)...

  4. Investigating Essential Factors on Students' Perceived Accomplishment and Enjoyment and Intention to Learn in Web Development

    ERIC Educational Resources Information Center

    Zhang, Yulei; Dang, Yan

    2015-01-01

    Web development is an important component in the curriculum of computer science and information systems areas. However, it is generally considered difficult to learn among students. In this study,we examined factors that could influence students' perceptions of accomplishment and enjoyment and their intention to learn in the web development…

  5. Service Efforts and Accomplishments (SEA) Reporting: A Challenge for School Financial Reporting.

    ERIC Educational Resources Information Center

    Walter, Donald L.

    1991-01-01

    Discusses the Government Accounting Standards Board (GASB) research concerning the identification of indicators of service efforts and service accomplishments. The GASB has proposed that financial reports should not only be useful in assessing accountability, but they should also assist in making economic, social, and political decisions. (six…

  6. An Accomplished Teacher's Use of Scaffolding during a Second-Grade Unit on Designing Games

    ERIC Educational Resources Information Center

    Chen, Weiyun; Rovegno, Inez; Cone, Stephen L.; Cone, Theresa P.

    2012-01-01

    The purpose of this study was to describe how an accomplished teacher taught second-grade students to design games that integrated movement and mathematics content. The participants were one physical education teacher, a classroom teacher, and an intact class of 20 second-grade students. Qualitative data were gathered through videotaping of all…

  7. Mechanisms for similarity based cooperation

    NASA Astrophysics Data System (ADS)

    Traulsen, A.

    2008-06-01

    Cooperation based on similarity has been discussed since Richard Dawkins introduced the term “green beard” effect. In these models, individuals cooperate based on an aribtrary signal (or tag) such as the famous green beard. Here, two different models for such tag based cooperation are analysed. As neutral drift is important in both models, a finite population framework is applied. The first model, which we term “cooperative tags” considers a situation in which groups of cooperators are formed by some joint signal. Defectors adopting the signal and exploiting the group can lead to a breakdown of cooperation. In this case, conditions are derived under which the average abundance of the more cooperative strategy exceeds 50%. The second model considers a situation in which individuals start defecting towards others that are not similar to them. This situation is termed “defective tags”. It is shown that in this case, individuals using tags to cooperate exclusively with their own kind dominate over unconditional cooperators.

  8. Creating Birds of Similar Feathers: Leveraging Similarity to Improve Teacher-Student Relationships and Academic Achievement

    ERIC Educational Resources Information Center

    Gehlbach, Hunter; Brinkworth, Maureen E.; King, Aaron M.; Hsu, Laura M.; McIntyre, Joseph; Rogers, Todd

    2016-01-01

    When people perceive themselves as similar to others, greater liking and closer relationships typically result. In the first randomized field experiment that leverages actual similarities to improve real-world relationships, we examined the affiliations between 315 9th grade students and their 25 teachers. Students in the treatment condition…

  9. Naturally fractured reservoirs: Optimized E and P strategies using a reaction-transport-mechanical simulator in an integrated approach. Summary of project accomplishments; Final report, September 30, 1998

    SciTech Connect

    Ortoleva, P.J.; Sundberg, K.R.; Hoak, T.E.

    1998-12-01

    Major accomplishments of this project occurred in three primary categories: (1) fractured reservoir location and characteristics prediction for exploration and production planning; (2) implications of geologic data analysis and synthesis for exploration and development programs; and (3) fractured reservoir production modeling. The results in each category will be discussed in turn. Seven detailed reports have been processed separately.

  10. Similarity Based Semantic Web Service Match

    NASA Astrophysics Data System (ADS)

    Peng, Hui; Niu, Wenjia; Huang, Ronghuai

    Semantic web service discovery aims at returning the most matching advertised services to the service requester by comparing the semantic of the request service with an advertised service. The semantic of a web service are described in terms of inputs, outputs, preconditions and results in Ontology Web Language for Service (OWL-S) which formalized by W3C. In this paper we proposed an algorithm to calculate the semantic similarity of two services by weighted averaging their inputs and outputs similarities. Case study and applications show the effectiveness of our algorithm in service match.

  11. Similar psychological distance reduces temporal discounting.

    PubMed

    Kim, Hyunji; Schnall, Simone; White, Mathew P

    2013-08-01

    People often prefer inferior options in the present even when options in the future are more lucrative. Five studies investigated whether decision making could be improved by manipulating construal level and psychological distance. In Studies 1a, 1b, and 2, temporal discounting was reduced when future rewards (trips to Paris) were construed at a relatively concrete level, thus inducing a similar level of construal to present rewards. By contrast, Studies 3 and 4 reduced temporal discounting by making present financial rewards more psychologically distant via a social proximity manipulation, and thus linked to a similar high level of construal as future rewards. These results suggest that people prefer the more lucrative option when comparing two intertemporal choices that are construed on a similar level instead of on a different level. Thus, changes in construal level and mental representations can be used to promote more desirable choices in economic decision making.

  12. Dreaming and waking: similarities and differences revisited.

    PubMed

    Kahan, Tracey L; LaBerge, Stephen P

    2011-09-01

    Dreaming is often characterized as lacking high-order cognitive (HOC) skills. In two studies, we test the alternative hypothesis that the dreaming mind is highly similar to the waking mind. Multiple experience samples were obtained from late-night REM sleep and waking, following a systematic protocol described in Kahan (2001). Results indicated that reported dreaming and waking experiences are surprisingly similar in their cognitive and sensory qualities. Concurrently, ratings of dreaming and waking experiences were markedly different on questions of general reality orientation and logical organization (e.g., the bizarreness or typicality of the events, actions, and locations). Consistent with other recent studies (e.g., Bulkeley & Kahan, 2008; Kozmová & Wolman, 2006), experiences sampled from dreaming and waking were more similar with respect to their process features than with respect to their structural features.

  13. Percolation in Self-Similar Networks

    NASA Astrophysics Data System (ADS)

    Serrano, M. Ángeles; Krioukov, Dmitri; Boguñá, Marián

    2011-01-01

    We provide a simple proof that graphs in a general class of self-similar networks have zero percolation threshold. The considered self-similar networks include random scale-free graphs with given expected node degrees and zero clustering, scale-free graphs with finite clustering and metric structure, growing scale-free networks, and many real networks. The proof and the derivation of the giant component size do not require the assumption that networks are treelike. Our results rely only on the observation that self-similar networks possess a hierarchy of nested subgraphs whose average degree grows with their depth in the hierarchy. We conjecture that this property is pivotal for percolation in networks.

  14. Aiming for Efficiency by Detecting Structural Similarity

    NASA Astrophysics Data System (ADS)

    Winter, Judith; Jeliazkov, Nikolay; Kühne, Gerold

    When applying XML-Retrieval in a distributed setting, efficiency issues have to be considered, e.g. reducing the network traffic involved in an swering a given query. The new Efficiency Track of INEX gave us the opportu nity to explore the possibility of improving both effectiveness and efficiency by exploiting structural similarity. We ran some of the track’s highly structured queries on our top-k search engine to analyze the impact of various structural similarity functions. We applied those functions first to the ranking and based on that to the query routing process. Our results indicate that detection of structural similarity can be used in order to re duce the amount of messages sent between distributed nodes and thus lead to more efficiency of the search.

  15. Self-Similar Compressible Free Vortices

    NASA Technical Reports Server (NTRS)

    vonEllenrieder, Karl

    1998-01-01

    Lie group methods are used to find both exact and numerical similarity solutions for compressible perturbations to all incompressible, two-dimensional, axisymmetric vortex reference flow. The reference flow vorticity satisfies an eigenvalue problem for which the solutions are a set of two-dimensional, self-similar, incompressible vortices. These solutions are augmented by deriving a conserved quantity for each eigenvalue, and identifying a Lie group which leaves the reference flow equations invariant. The partial differential equations governing the compressible perturbations to these reference flows are also invariant under the action of the same group. The similarity variables found with this group are used to determine the decay rates of the velocities and thermodynamic variables in the self-similar flows, and to reduce the governing partial differential equations to a set of ordinary differential equations. The ODE's are solved analytically and numerically for a Taylor vortex reference flow, and numerically for an Oseen vortex reference flow. The solutions are used to examine the dependencies of the temperature, density, entropy, dissipation and radial velocity on the Prandtl number. Also, experimental data on compressible free vortex flow are compared to the analytical results, the evolution of vortices from initial states which are not self-similar is discussed, and the energy transfer in a slightly-compressible vortex is considered.

  16. Estimation of pairwise sequence similarity of mammalian enhancers with word neighbourhood counts

    PubMed Central

    Göke, Jonathan; Schulz, Marcel H.; Lasserre, Julia; Vingron, Martin

    2012-01-01

    Motivation: The identity of cells and tissues is to a large degree governed by transcriptional regulation. A major part is accomplished by the combinatorial binding of transcription factors at regulatory sequences, such as enhancers. Even though binding of transcription factors is sequence-specific, estimating the sequence similarity of two functionally similar enhancers is very difficult. However, a similarity measure for regulatory sequences is crucial to detect and understand functional similarities between two enhancers and will facilitate large-scale analyses like clustering, prediction and classification of genome-wide datasets. Results: We present the standardized alignment-free sequence similarity measure N2, a flexible framework that is defined for word neighbourhoods. We explore the usefulness of adding reverse complement words as well as words including mismatches into the neighbourhood. On simulated enhancer sequences as well as functional enhancers in mouse development, N2 is shown to outperform previous alignment-free measures. N2 is flexible, faster than competing methods and less susceptible to single sequence noise and the occurrence of repetitive sequences. Experiments on the mouse enhancers reveal that enhancers active in different tissues can be separated by pairwise comparison using N2. Conclusion: N2 represents an improvement over previous alignment-free similarity measures without compromising speed, which makes it a good candidate for large-scale sequence comparison of regulatory sequences. Availability: The software is part of the open-source C++ library SeqAn (www.seqan.de) and a compiled version can be downloaded at http://www.seqan.de/projects/alf.html Contact: goeke@molgen.mpg.de; vingron@molgen.mpg.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22247280

  17. National Low-Level Waste Management Program final summary report of key activities and accomplishments for fiscal year 1996

    SciTech Connect

    Garcia, R.S.

    1996-12-01

    To assist the Department of Energy (DOE) in fulfilling its responsibilities under the Low-Level Radioactive Waste Policy Amendments Act of 1985, the National Low-Level Waste Management Program (NLLWMP) outlines the key activities tat the NLLWMP will accomplish in the following fiscal year. Additional activities are added during the fiscal year as necessary to accomplish programmatic goals. This report summarizes the activities and accomplishments of the NLLWMP during Fiscal Year 1996.

  18. Simpler images, better results

    NASA Astrophysics Data System (ADS)

    Chance, Britton

    1999-03-01

    The very rapid development of optical technology has followed a pattern similar to that of nuclear magnetic resonance: first, spectroscopy and then imaging. The accomplishments in spectroscopy have been significant--among them, early detection of hematomas and quantitative oximetry (assuming that time and frequency domain instruments are used). Imaging has progressed somewhat later. The first images were obtained in Japan and USA a few years ago, particularly of parietal stimulation of the human brain. Since then, rapid applications to breast and limb, together with higher resolution of the brain now make NIR imaging of functional activation and tumor detection readily available, reliable and affordable devices. The lecture has to do with the applications of imaging to these three areas, particularly to prefrontal imaging of cognitive function, of breast tumor detection, and of localized muscle activation in exercise. The imaging resolution achievable in functional activation appears to be FWHM of 4 mm. The time required for an image is a few seconds or even much less. Breast image detection at 50 microsecond(s) ec/pixel results in images obtainable in a few seconds or shorter times (bandwidths of the kHz are available). Finally, imaging of the body organs is under study in this laboratory, particularly in the in utero fetus. It appears that the photon migration theory now leads to the development of a wide number of images for human subject tissue spectroscopy and imaging.

  19. Similarity theory of lubricated Hertzian contacts

    NASA Astrophysics Data System (ADS)

    Snoeijer, J. H.; Eggers, J.; Venner, C. H.

    2013-10-01

    We consider a heavily loaded, lubricated contact between two elastic bodies at relative speed U, such that there is substantial elastic deformation. As a result of the interplay between hydrodynamics and non-local elasticity, a fluid film develops between the two solids, whose thickness scales as U3/5. The film profile h is selected by a universal similarity solution along the upstream inlet. Another similarity solution is valid at the outlet, which exhibits a local minimum in the film thickness. The two solutions are connected by a hyperbolic problem underneath the contact. Our asymptotic results for a soft sphere pressed against a hard wall are shown to agree with both experiment and numerical simulations.

  20. Measuring structural similarity in large online networks.

    PubMed

    Shi, Yongren; Macy, Michael

    2016-09-01

    Structural similarity based on bipartite graphs can be used to detect meaningful communities, but the networks have been tiny compared to massive online networks. Scalability is important in applications involving tens of millions of individuals with highly skewed degree distributions. Simulation analysis holding underlying similarity constant shows that two widely used measures - Jaccard index and cosine similarity - are biased by the distribution of out-degree in web-scale networks. However, an alternative measure, the Standardized Co-incident Ratio (SCR), is unbiased. We apply SCR to members of Congress, musical artists, and professional sports teams to show how massive co-following on Twitter can be used to map meaningful affiliations among cultural entities, even in the absence of direct connections to one another. Our results show how structural similarity can be used to map cultural alignments and demonstrate the potential usefulness of social media data in the study of culture, politics, and organizations across the social and behavioral sciences. PMID:27480374

  1. Fort Collins Science Center: science accomplishments for fiscal years 2012 and 2013

    USGS Publications Warehouse

    Wilson, Juliette T.; Hamilton, David B.

    2014-01-01

    The Fort Collins Science Center (FORT) is a multi-disciplinary research and development center of the U.S. Geological Survey (USGS) located in Fort Collins, Colorado. Organizationally, FORT is within the USGS Southwest Region, although our work extends across the Nation and into several other countries. FORT research focuses on needs of the land- and water-management bureaus within the U.S. Department of the Interior (DOI), other Federal agencies, and those of State and non-government organizations. As a Science Center, we emphasize a multi-disciplinary science approach to provide information for resource-management decisionmaking. FORT’s vision is to maintain and continuously improve the integrated, collaborative, world-class research needed to inform effective, science-based land and resource management. Our science and technological development activities and unique capabilities support all USGS scientific Mission Areas and contribute to successful, collaborative science efforts across the USGS and DOI. We organized our report into an Executive Summary, a cross-reference table, and an appendix. The executive summary provides brief highlights of some key FORT accomplishments for each Mission Area. The table cross-references all major FY2012 and FY2013 science accomplishments with the various Mission Areas that each supports. The one-page accomplishment descriptions in the appendix are organized by USGS Mission Area and describe the many and diverse ways in which our science is applied to resource issues. As in prior years, lists of all FY2012 and FY2013 publications and other product types also are appended.

  2. Similarly shaped letters evoke similar colors in grapheme-color synesthesia.

    PubMed

    Brang, David; Rouw, Romke; Ramachandran, V S; Coulson, Seana

    2011-04-01

    Grapheme-color synesthesia is a neurological condition in which viewing numbers or letters (graphemes) results in the concurrent sensation of color. While the anatomical substrates underlying this experience are well understood, little research to date has investigated factors influencing the particular colors associated with particular graphemes or how synesthesia occurs developmentally. A recent suggestion of such an interaction has been proposed in the cascaded cross-tuning (CCT) model of synesthesia, which posits that in synesthetes connections between grapheme regions and color area V4 participate in a competitive activation process, with synesthetic colors arising during the component-stage of grapheme processing. This model more directly suggests that graphemes sharing similar component features (lines, curves, etc.) should accordingly activate more similar synesthetic colors. To test this proposal, we created and regressed synesthetic color-similarity matrices for each of 52 synesthetes against a letter-confusability matrix, an unbiased measure of visual similarity among graphemes. Results of synesthetes' grapheme-color correspondences indeed revealed that more similarly shaped graphemes corresponded with more similar synesthetic colors, with stronger effects observed in individuals with more intense synesthetic experiences (projector synesthetes). These results support the CCT model of synesthesia, implicate early perceptual mechanisms as driving factors in the elicitation of synesthetic hues, and further highlight the relationship between conceptual and perceptual factors in this phenomenon.

  3. Recent Accomplishments in the Irradiation Testing of Engineering-Scale Monolithic Fuel Specimens

    SciTech Connect

    N.E. Woolstenhulme; D.M. Wachs; M.K. Meyer; H.W. Glunz; R.B. Nielson

    2012-10-01

    The US fuel development team is focused on qualification and demonstration of the uranium-molybdenum monolithic fuel including irradiation testing of engineering-scale specimens. The team has recently accomplished the successful irradiation of the first monolithic multi-plate fuel element assembly within the AFIP-7 campaign. The AFIP-6 MKII campaign, while somewhat truncated by hardware challenges, exhibited successful irradiation of a large-scale monolithic specimen under extreme irradiation conditions. The channel gap and ultrasonic data are presented for AFIP-7 and AFIP-6 MKII, respectively. Finally, design concepts are summarized for future irradiations such as the base fuel demonstration and design demonstration experiment campaigns.

  4. The Solar Thermal Design Assistance Center report of its activities and accomplishments in Fiscal Year 1993

    SciTech Connect

    Menicucci, D.F.

    1994-03-01

    The Solar Thermal Design Assistance Center (STDAC) at Sandia National Laboratories is a resource provided by the US Department of Energy`s Solar Thermal Program. Its major objectives are to accelerate the use of solar thermal systems through (a) direct technical assistance to users, (b) cooperative test, evaluation, and development efforts with private industry, and (c) educational outreach activities. This report outlines the major activities and accomplishments of the STDAC in Fiscal Year 1993. The report also contains a comprehensive list of persons who contacted the STDAC by telephone for information or technical consulting.

  5. Overview and Recent Accomplishments of Advanced Mirror Technology Development Phase 2 (AMTD-2)

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2015-01-01

    AMTD uses a science-driven systems engineering approach to define & execute a long-term strategy to mature technologies necessary to enable future large aperture space telescopes. Because we cannot predict the future, we are pursuing multiple technology paths including monolithic & segmented mirrors. Assembled outstanding team from academia, industry & government; experts in science & space telescope engineering. Derived engineering specifications from science measurement needs & implementation constraints. Maturing 6 critical technologies required to enable 4 to 8 meter UVOIR space telescope mirror assemblies for both general astrophysics & ultra-high contrast exoplanet imaging. AMTD achieving all its goals & accomplishing all its milestones.

  6. Overview and Recent Accomplishments of Advanced Mirror Technology Development (AMTD) for Very Large Space Telescopes

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2013-01-01

    AMTD uses a science-driven systems engineering approach to define & execute a long-term strategy to mature technologies necessary to enable future large aperture space telescopes. Because we cannot predict the future, we are pursuing multiple technology paths including monolithic & segmented mirrors. Assembled outstanding team from academia, industry & government; experts in science & space telescope engineering. Derived engineering specifications from science measurement needs & implementation constraints. Maturing 6 critical technologies required to enable 4 to 8 meter UVOIR space telescope mirror assemblies for both general astrophysics & ultra-high contrast exoplanet imaging. AMTD achieving all its goals & accomplishing all its milestones.

  7. Nuclear Thermal Propulsion (NTP) Development Activities at the NASA Marshall Space Flight Center - 2006 Accomplishments

    NASA Technical Reports Server (NTRS)

    Ballard, Richard O.

    2007-01-01

    In 2005-06, the Prometheus program funded a number of tasks at the NASA-Marshall Space Flight Center (MSFC) to support development of a Nuclear Thermal Propulsion (NTP) system for future manned exploration missions. These tasks include the following: 1. NTP Design Develop Test & Evaluate (DDT&E) Planning 2. NTP Mission & Systems Analysis / Stage Concepts & Engine Requirements 3. NTP Engine System Trade Space Analysis and Studies 4. NTP Engine Ground Test Facility Assessment 5. Non-Nuclear Environmental Simulator (NTREES) 6. Non-Nuclear Materials Fabrication & Evaluation 7. Multi-Physics TCA Modeling. This presentation is a overview of these tasks and their accomplishments

  8. Explosion Source Similarity Analysis via SVD

    NASA Astrophysics Data System (ADS)

    Yedlin, Matthew; Ben Horin, Yochai; Margrave, Gary

    2016-04-01

    An important seismological ingredient for establishing a regional seismic nuclear discriminant is the similarity analysis of a sequence of explosion sources. To investigate source similarity, we are fortunate to have access to a sequence of 1805 three-component recordings of quarry blasts, shot from March 2002 to January 2015. The centroid of these blasts has an estimated location 36.3E and 29.9N. All blasts were detonated by JPMC (Jordan Phosphate Mines Co.) All data were recorded at the Israeli NDC, HFRI, located at 30.03N and 35.03E. Data were first winnowed based on the distribution of maximum amplitudes in the neighborhood of the P-wave arrival. The winnowed data were then detrended using the algorithm of Cleveland et al (1990). The detrended data were bandpass filtered between .1 to 12 Hz using an eighth order Butterworth filter. Finally, data were sorted based on maximum trace amplitude. Two similarity analysis approaches were used. First, for each component, the entire suite of traces was decomposed into its eigenvector representation, by employing singular-valued decomposition (SVD). The data were then reconstructed using 10 percent of the singular values, with the resulting enhancement of the S-wave and surface wave arrivals. The results of this first method are then compared to the second analysis method based on the eigenface decomposition analysis of Turk and Pentland (1991). While both methods yield similar results in enhancement of data arrivals and reduction of data redundancy, more analysis is required to calibrate the recorded data to charge size, a quantity that was not available for the current study. References Cleveland, R. B., Cleveland, W. S., McRae, J. E., and Terpenning, I., Stl: A seasonal-trend decomposition procedure based on loess, Journal of Official Statistics, 6, No. 1, 3-73, 1990. Turk, M. and Pentland, A., Eigenfaces for recognition. Journal of cognitive neuroscience, 3(1), 71-86, 1991.

  9. "That's My Job": Comparing the Beliefs of More and Less Accomplished Special Educators Related to Their Roles and Responsibilities

    ERIC Educational Resources Information Center

    Urbach, Jennifer; Moore, Brooke A.; Klingner, Janette K.; Galman, Sally; Haager, Diane; Brownell, Mary T.; Dingle, Mary

    2015-01-01

    The purpose of this study is to understand special education teachers' beliefs regarding their roles and responsibilities and to determine how these beliefs differ among more and less accomplished teachers. In this study, the authors examine the interviews of special education teachers identified as either more or less accomplished based on the…

  10. Sigma Team for Advanced Actinide Recycle FY2015 Accomplishments and Directions

    SciTech Connect

    Moyer, Bruce A.

    2015-09-30

    The Sigma Team for Minor Actinide Recycle (STAAR) has made notable progress in FY 2015 toward the overarching goal to develop more efficient separation methods for actinides in support of the United States Department of Energy (USDOE) objective of sustainable fuel cycles. Research in STAAR has been emphasizing the separation of americium and other minor actinides (MAs) to enable closed nuclear fuel recycle options, mainly within the paradigm of aqueous reprocessing of used oxide nuclear fuel dissolved in nitric acid. Its major scientific challenge concerns achieving selectivity for trivalent actinides vs lanthanides. Not only is this challenge yielding to research advances, but technology concepts such as ALSEP (Actinide Lanthanide Separation) are maturing toward demonstration readiness. Efforts are organized in five task areas: 1) combining bifunctional neutral extractants with an acidic extractant to form a single process solvent, developing a process flowsheet, and demonstrating it at bench scale; 2) oxidation of Am(III) to Am(VI) and subsequent separation with other multivalent actinides; 3) developing an effective soft-donor solvent system for An(III) selective extraction using mixed N,O-donor or all-N donor extractants such as triazinyl pyridine compounds; 4) testing of inorganic and hybrid-type ion exchange materials for MA separations; and 5) computer-aided molecular design to identify altogether new extractants and complexants and theory-based experimental data interpretation. Within these tasks, two strategies are employed, one involving oxidation of americium to its pentavalent or hexavalent state and one that seeks to selectively complex trivalent americium either in the aqueous phase or the solvent phase. Solvent extraction represents the primary separation method employed, though ion exchange and crystallization play an important role. Highlights of accomplishments include: Confirmation of the first-ever electrolytic oxidation of Am(III) in a

  11. Life paths and accomplishments of mathematically precocious males and females four decades later.

    PubMed

    Lubinski, David; Benbow, Camilla P; Kell, Harrison J

    2014-12-01

    Two cohorts of intellectually talented 13-year-olds were identified in the 1970s (1972-1974 and 1976-1978) as being in the top 1% of mathematical reasoning ability (1,037 males, 613 females). About four decades later, data on their careers, accomplishments, psychological well-being, families, and life preferences and priorities were collected. Their accomplishments far exceeded base-rate expectations: Across the two cohorts, 4.1% had earned tenure at a major research university, 2.3% were top executives at "name brand" or Fortune 500 companies, and 2.4% were attorneys at major firms or organizations; participants had published 85 books and 7,572 refereed articles, secured 681 patents, and amassed $358 million in grants. For both males and females, mathematical precocity early in life predicts later creative contributions and leadership in critical occupational roles. On average, males had incomes much greater than their spouses', whereas females had incomes slightly lower than their spouses'. Salient sex differences that paralleled the differential career outcomes of the male and female participants were found in lifestyle preferences and priorities and in time allocation. PMID:25384550

  12. Life paths and accomplishments of mathematically precocious males and females four decades later.

    PubMed

    Lubinski, David; Benbow, Camilla P; Kell, Harrison J

    2014-12-01

    Two cohorts of intellectually talented 13-year-olds were identified in the 1970s (1972-1974 and 1976-1978) as being in the top 1% of mathematical reasoning ability (1,037 males, 613 females). About four decades later, data on their careers, accomplishments, psychological well-being, families, and life preferences and priorities were collected. Their accomplishments far exceeded base-rate expectations: Across the two cohorts, 4.1% had earned tenure at a major research university, 2.3% were top executives at "name brand" or Fortune 500 companies, and 2.4% were attorneys at major firms or organizations; participants had published 85 books and 7,572 refereed articles, secured 681 patents, and amassed $358 million in grants. For both males and females, mathematical precocity early in life predicts later creative contributions and leadership in critical occupational roles. On average, males had incomes much greater than their spouses', whereas females had incomes slightly lower than their spouses'. Salient sex differences that paralleled the differential career outcomes of the male and female participants were found in lifestyle preferences and priorities and in time allocation.

  13. Overview and Accomplishments of Advanced Mirror Technology Development Phase 2 (AMTD-2) Project

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2015-01-01

    The Advance Mirror Technology Development (AMTD) project is in Phase 2 of a multiyear effort, initiated in FY12, to mature by at least a half TRL step critical technologies required to enable 4 meter or larger UVOIR space telescope primary mirror assemblies for both general astrophysics and ultra-high contrast observations of exoplanets. AMTD Phase 1 completed all of its goals and accomplished all of its milestones. AMTD Phase 2 started in 2014. Key accomplishments include deriving primary mirror engineering specifications from science requirements; developing integrated modeling tools and using those tools to perform parametric design trades; and demonstrating new mirror technologies via sub-scale fabrication and test. AMTD-1 demonstrated the stacked core technique by making a 43-cm diameter 400 mm thick 'biscuit-cut' of a 4-m class mirror. AMTD-2 is demonstrating lateral scalability of the stacked core method by making a 1.5 meter 1/3rd scale model of a 4-m class mirror.

  14. Relations between premise similarity and inductive strength.

    PubMed

    Heit, Evan; Feeney, Aidan

    2005-04-01

    According to the diversity principle, diverse evidence is strong evidence. There has been considerable evidence that people respect this principle in inductive reasoning. However, exceptions may be particularly informative. Medin, Coley, Storms, and Hayes (2003) introduced a relevance theory of inductive reasoning and used this theory to predict exceptions, including the nondiversity-by-property-reinforcement effect. A new experiment in which this phenomenon was investigated is reported here. Subjects made inductive strength judgments and similarity judgments for stimuli from Medin et al. (2003). The inductive strength judgments showed the same pattern as that in Medin et al. (2003); however, the similarity judgments suggested that the pattern should be interpreted as a diversity effect, rather than as a nondiversity effect. It is concluded that the evidence regarding the predicted nondiversity-by-property-reinforcement effect does not give distinctive support for relevance theory, although this theory does address other results.

  15. Dependency Similarity, Attraction and Perceived Happiness.

    ERIC Educational Resources Information Center

    Pandey, Janak

    1978-01-01

    Subjects were asked to evaluate either a similar personality or a dissimilar personality. Subjects rated similar others more positively than dissimilar others and, additionally, perceived similar others as more helpful and sympathetic than dissimilar others. (Author)

  16. Hierarchical similarity transformations between Gaussian mixtures.

    PubMed

    Rigas, George; Nikou, Christophoros; Goletsis, Yorgos; Fotiadis, Dimitrios I

    2013-11-01

    In this paper, we propose a method to estimate the density of a data space represented by a geometric transformation of an initial Gaussian mixture model. The geometric transformation is hierarchical, and it is decomposed into two steps. At first, the initial model is assumed to undergo a global similarity transformation modeled by translation, rotation, and scaling of the model components. Then, to increase the degrees of freedom of the model and allow it to capture fine data structures, each individual mixture component may be transformed by another, local similarity transformation, whose parameters are distinct for each component of the mixture. In addition, to constrain the order of magnitude of the local transformation (LT) with respect to the global transformation (GT), zero-mean Gaussian priors are imposed onto the local parameters. The estimation of both GT and LT parameters is obtained through the expectation maximization framework. Experiments on artificial data are conducted to evaluate the proposed model, with varying data dimensionality, number of model components, and transformation parameters. In addition, the method is evaluated using real data from a speech recognition task. The obtained results show a high model accuracy and demonstrate the potential application of the proposed method to similar classification problems. PMID:24808615

  17. Self-similarity of complex networks.

    PubMed

    Song, Chaoming; Havlin, Shlomo; Makse, Hernán A

    2005-01-27

    Complex networks have been studied extensively owing to their relevance to many real systems such as the world-wide web, the Internet, energy landscapes and biological and social networks. A large number of real networks are referred to as 'scale-free' because they show a power-law distribution of the number of links per node. However, it is widely believed that complex networks are not invariant or self-similar under a length-scale transformation. This conclusion originates from the 'small-world' property of these networks, which implies that the number of nodes increases exponentially with the 'diameter' of the network, rather than the power-law relation expected for a self-similar structure. Here we analyse a variety of real complex networks and find that, on the contrary, they consist of self-repeating patterns on all length scales. This result is achieved by the application of a renormalization procedure that coarse-grains the system into boxes containing nodes within a given 'size'. We identify a power-law relation between the number of boxes needed to cover the network and the size of the box, defining a finite self-similar exponent. These fundamental properties help to explain the scale-free nature of complex networks and suggest a common self-organization dynamics.

  18. Compressive Sequential Learning for Action Similarity Labeling.

    PubMed

    Qin, Jie; Liu, Li; Zhang, Zhaoxiang; Wang, Yunhong; Shao, Ling

    2016-02-01

    Human action recognition in videos has been extensively studied in recent years due to its wide range of applications. Instead of classifying video sequences into a number of action categories, in this paper, we focus on a particular problem of action similarity labeling (ASLAN), which aims at verifying whether a pair of videos contain the same type of action or not. To address this challenge, a novel approach called compressive sequential learning (CSL) is proposed by leveraging the compressive sensing theory and sequential learning. We first project data points to a low-dimensional space by effectively exploring an important property in compressive sensing: the restricted isometry property. In particular, a very sparse measurement matrix is adopted to reduce the dimensionality efficiently. We then learn an ensemble classifier for measuring similarities between pairwise videos by iteratively minimizing its empirical risk with the AdaBoost strategy on the training set. Unlike conventional AdaBoost, the weak learner for each iteration is not explicitly defined and its parameters are learned through greedy optimization. Furthermore, an alternative of CSL named compressive sequential encoding is developed as an encoding technique and followed by a linear classifier to address the similarity-labeling problem. Our method has been systematically evaluated on four action data sets: ASLAN, KTH, HMDB51, and Hollywood2, and the results show the effectiveness and superiority of our method for ASLAN.

  19. Search of phenotype related candidate genes using gene ontology-based semantic similarity and protein interaction information: application to Brugada syndrome.

    PubMed

    Massanet, Raimon; Gallardo-Chacon, Joan-Josep; Caminal, Pere; Perera, Alexandre

    2009-01-01

    This work presents a methodology for finding phenotype candidate genes starting from a set of known related genes. This is accomplished by automatically mining and organizing the available scientific literature using Gene Ontology-based semantic similarity. As a case study, Brugada syndrome related genes have been used as input in order to obtain a list of other possible candidate genes related with this disease. Brugada anomaly produces a typical alteration in the Electrocardiogram and carriers of the disease show an increased probability of sudden death. Results show a set of semantically coherent proteins that are shown to be related with synaptic transmission and muscle contraction physiological processes.

  20. A 2D chaotic path planning for mobile robots accomplishing boundary surveillance missions in adversarial conditions

    NASA Astrophysics Data System (ADS)

    Curiac, Daniel-Ioan; Volosencu, Constantin

    2014-10-01

    The path-planning algorithm represents a crucial issue for every autonomous mobile robot. In normal circumstances a patrol robot will compute an optimal path to ensure its task accomplishment, but in adversarial conditions the problem is getting more complicated. Here, the robot’s trajectory needs to be altered into a misleading and unpredictable path to cope with potential opponents. Chaotic systems provide the needed framework for obtaining unpredictable motion in all of the three basic robot surveillance missions: area, points of interests and boundary monitoring. Proficient approaches have been provided for the first two surveillance tasks, but for boundary patrol missions no method has been reported yet. This paper addresses the mentioned research gap by proposing an efficient method, based on chaotic dynamic of the Hénon system, to ensure unpredictable boundary patrol on any shape of chosen closed contour.

  1. The Legacy of the Space Shuttle Program: Scientific and Engineering Accomplishments

    NASA Technical Reports Server (NTRS)

    Torrez, Jonathan

    2009-01-01

    The goal of this project was to assist in the creation of the appendix for the book being written about the Space Shuttle that is titled The Legacy of the Space Shuttle Program: Scientific and Engineering Accomplishments. The specific responsibility of the intern was the creation of the human health and performance (life sciences) and space biology sections of the appendix. This included examining and finalizing the list of flights with life sciences and space biology experiments flown aboard them, researching the experiments performed, synopsizing each experiment into two sentences, and placing the synopses into an appendix template. Overall, approximately 70 flights had their experiments synopsized and a good method for researching and construction of the template was established this summer.

  2. Advanced Industrial Materials (AIM) program. Compilation of project summaries and significant accomplishments FY 1996

    SciTech Connect

    1997-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven {open_quotes}Vision Industries{close_quotes} that use about 80% of industrial energy and generated about 90% of industrial wastes. These are: (1) Aluminum; (2) Chemical; (3) Forest Products; (4) Glass; (5) Metal Casting; (6) Refineries; and (7) Steel. This report is a compilation of project summaries and significant accomplishments on materials.

  3. Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas.

    PubMed

    Smith, David; Španěl, Patrik

    2016-06-01

    This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chemistry required to realize more robust analyses. The challenge of breath analysis is given special attention because, when achieved, it renders analysis of other air media relatively straightforward. Brief overviews are given of recent SIFT-MS breath analyses by leading research groups, noting the desirability of detection and quantification of single volatile biomarkers rather than reliance on statistical analyses, if breath analysis is to be accepted into clinical practice. A 'strengths, weaknesses, opportunities and threats' analysis of SIFT-MS is made, which should help to increase its utility for trace gas analysis. PMID:27212131

  4. Advanced Mirror Technology Development (AMTD) Project: Overview and Year 4 Accomplishments

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2016-01-01

    The Advanced Mirror Technology Development (AMTD) project is in Phase 2 of a multiyear effort initiated in Fiscal Year (FY) 2012, to mature toward the next Technology Readiness Level (TRL) critical technologies required to enable 4-m-or-larger monolithic or segmented ultraviolet, optical, and infrared (UVOIR) space telescope primary-mirror assemblies for general astrophysics and ultra-high-contrast observations of exoplanets. Key hardware accomplishments of 2015/16 are the successful low-temperature fusion of a 1.5-meter diameter ULE mirror that is a 1/3rd scale model of a 4-meter mirror and the initiation of polishing of a 1.2-meter Extreme-Lightweight Zerodur mirror. Critical to AMTD's success is an integrated team of scientists, systems engineers, and technologists; and a science-driven systems engineering approach.

  5. Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas.

    PubMed

    Smith, David; Španěl, Patrik

    2016-06-01

    This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chemistry required to realize more robust analyses. The challenge of breath analysis is given special attention because, when achieved, it renders analysis of other air media relatively straightforward. Brief overviews are given of recent SIFT-MS breath analyses by leading research groups, noting the desirability of detection and quantification of single volatile biomarkers rather than reliance on statistical analyses, if breath analysis is to be accepted into clinical practice. A 'strengths, weaknesses, opportunities and threats' analysis of SIFT-MS is made, which should help to increase its utility for trace gas analysis.

  6. Accomplishing the Visions for Teacher Education Programs Advocated in the National Science Education Standards

    NASA Astrophysics Data System (ADS)

    Akcay, Hakan; Yager, Robert

    2010-10-01

    The purpose of this study was to investigate the advantages of an approach to instruction using current problems and issues as curriculum organizers and illustrating how teaching must change to accomplish real learning. The study sample consisted of 41 preservice science teachers (13 males and 28 females) in a model science teacher education program. Both qualitative and quantitative research methods were used to determine success with science discipline-specific “Societal and Educational Applications” courses as one part of a total science teacher education program at a large Midwestern university. Students were involved with idea generation, consideration of multiple points of views, collaborative inquiries, and problem solving. All of these factors promoted grounded instruction using constructivist perspectives that situated science with actual experiences in the lives of students.

  7. A review of satellite time-transfer technology: Accomplishments and future applications

    NASA Technical Reports Server (NTRS)

    Cooper, R. S.; Chi, A. R.

    1978-01-01

    The research accomplishments by NASA in meeting the needs of the space program for precise time in satellite tracking are presented. As a major user of precise time signals for clock synchronization of NASA's worldwide satellite tracking networks, the agency provides much of the necessary impetus for the development of stable frequency sources and time synchronization technology. The precision time required for both satellite tracking and space science experiments has increased at a rate of about one order of magnitude per decade from 1 millisecond in the 1950's to 100 microseconds during the Apollo era in the 1960's to 10 microseconds in the 1970's. For the Tracking and Data Relay Satellite System, satellite timing requirements will be extended to 1 microsecond and below. These requirements are needed for spacecraft autonomy and data packeting.

  8. Space Shuttle Program Primary Avionics Software System (PASS) Success Legacy -Major Accomplishments and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Orr, James K.

    2010-01-01

    This presentation has shown the accomplishments of the PASS project over three decades and highlighted the lessons learned. Over the entire time, our goal has been to continuously improve our process, implement automation for both quality and increased productivity, and identify and remove all defects due to prior execution of a flawed process in addition to improving our processes following identification of significant process escapes. Morale and workforce instability have been issues, most significantly during 1993 to 1998 (period of consolidation in aerospace industry). The PASS project has also consulted with others, including the Software Engineering Institute, so as to be an early evaluator, adopter, and adapter of state-of-the-art software engineering innovations.

  9. NASA/Army rotorcraft transmission research, a review of recent significant accomplishments

    SciTech Connect

    Krantz, T.L.

    1994-03-01

    A joint helicopter transmission research program between NASA Lewis Research Center and the U.S. Army Research Lab has existed since 1970. Research goals are to reduce weight and noise while increasing life, reliability, and safety. These research goals are achieved by the NASA/Army Mechanical Systems Technology Branch through both in-house research and cooperative research projects with university and industry partners. Some recent significant technical accomplishments produced by this cooperative research are reviewed. The following research projects are reviewed: oil-off survivability of tapered roller bearings, design and evaluation of high contact ratio gearing, finite element analysis of spiral bevel gears, computer numerical control grinding of spiral bevel gears, gear dynamics code validation, computer program for life and reliability of helicopter transmissions, planetary gear train efficiency study, and the Advanced Rotorcraft Transmission (ART) program.

  10. NASA/Army Rotorcraft Transmission Research, a Review of Recent Significant Accomplishments

    NASA Technical Reports Server (NTRS)

    Krantz, Timothy L.

    1994-01-01

    A joint helicopter transmission research program between NASA Lewis Research Center and the U.S. Army Research Lab has existed since 1970. Research goals are to reduce weight and noise while increasing life, reliability, and safety. These research goals are achieved by the NASA/Army Mechanical Systems Technology Branch through both in-house research and cooperative research projects with university and industry partners. Some recent significant technical accomplishments produced by this cooperative research are reviewed. The following research projects are reviewed: oil-off survivability of tapered roller bearings, design and evaluation of high contact ratio gearing, finite element analysis of spiral bevel gears, computer numerical control grinding of spiral bevel gears, gear dynamics code validation, computer program for life and reliability of helicopter transmissions, planetary gear train efficiency study, and the Advanced Rotorcraft Transmission (ART) program.

  11. Affordability as a discursive accomplishment in a changing National Health Service.

    PubMed

    Russell, Jill; Greenhalgh, Trisha

    2012-12-01

    Health systems worldwide face the challenges of rationing. The English National Health Service (NHS) was founded on three core principles: universality, comprehensiveness, and free at the point of delivery. Yet patients are increasingly hearing that some treatments are unaffordable on the NHS. We considered affordability as a social accomplishment and sought to explore how those charged with allocating NHS resources achieved this in practice. We undertook a linguistic ethnography to examine the work practices of resource allocation committees in three Primary Care Trusts (PCTs) in England between 2005 and 2012, specifically deliberations over 'individual funding requests' (IFRs)--requests by patients and their doctors for the PCT to support a treatment not routinely funded. We collected and analysed a diverse dataset comprising policy documents, legal judgements, audio recordings, ethnographic field notes and emails from PCT committee meetings, interviews and a focus group with committee members. We found that the fundamental values of universality and comprehensiveness strongly influenced the culture of these NHS organisations, and that in this context, accomplishing affordability was not easy. Four discursive practices served to confer legitimacy on affordability as a guiding value of NHS health care: (1) categorising certain treatments as only eligible for NHS funding if patients could prove 'exceptional' circumstances; (2) representing resource allocation decisions as being not (primarily) about money; (3) indexical labelling of affordability as an ethical principle, and (4) recontextualising legal judgements supporting refusal of NHS treatment on affordability grounds as 'rational'. The overall effect of these discursive practices was that denying treatment to patients became reasonable and rational for an organisation even while it continued to espouse traditional NHS values. We conclude that deliberations about the funding of treatments at the margins of NHS

  12. Affordability as a discursive accomplishment in a changing National Health Service.

    PubMed

    Russell, Jill; Greenhalgh, Trisha

    2012-12-01

    Health systems worldwide face the challenges of rationing. The English National Health Service (NHS) was founded on three core principles: universality, comprehensiveness, and free at the point of delivery. Yet patients are increasingly hearing that some treatments are unaffordable on the NHS. We considered affordability as a social accomplishment and sought to explore how those charged with allocating NHS resources achieved this in practice. We undertook a linguistic ethnography to examine the work practices of resource allocation committees in three Primary Care Trusts (PCTs) in England between 2005 and 2012, specifically deliberations over 'individual funding requests' (IFRs)--requests by patients and their doctors for the PCT to support a treatment not routinely funded. We collected and analysed a diverse dataset comprising policy documents, legal judgements, audio recordings, ethnographic field notes and emails from PCT committee meetings, interviews and a focus group with committee members. We found that the fundamental values of universality and comprehensiveness strongly influenced the culture of these NHS organisations, and that in this context, accomplishing affordability was not easy. Four discursive practices served to confer legitimacy on affordability as a guiding value of NHS health care: (1) categorising certain treatments as only eligible for NHS funding if patients could prove 'exceptional' circumstances; (2) representing resource allocation decisions as being not (primarily) about money; (3) indexical labelling of affordability as an ethical principle, and (4) recontextualising legal judgements supporting refusal of NHS treatment on affordability grounds as 'rational'. The overall effect of these discursive practices was that denying treatment to patients became reasonable and rational for an organisation even while it continued to espouse traditional NHS values. We conclude that deliberations about the funding of treatments at the margins of NHS

  13. International Space Station Research: Accomplishments and Pathways for Exploration and Fundamental Research

    NASA Technical Reports Server (NTRS)

    Robinson, Julie A.

    2007-01-01

    Beginning with the launch of the European Columbus module planned for December 2007, we approach a transition in the assembly of the International Space Station (ISS) that is of great importance for the sciences. During the following 18 months, we will operate the first experiments in Columbus physical science resource facilities and also launch and commission the Japanese Kibo module. In addition, two Multi-purpose Logistics Module (MPLM) flights will deliver the U.S. Combustion Integrated Rack (CIR) and Fluids Integrated Rack (FIR) along with their first science experiments. These facilities provide significant new capabilities for basic and applied physical science research in microgravity. New life support technologies will come online throughout 2008, and we will reach the milestone of a 6-person crew planned for April 2009. A larger crew enables significant more scientific use of all the facilities for the life of ISS. Planning for the use of the International Space Station as a national laboratory is also maturing as we near the completion of assembly, enabling access to ISS as a research platform for other government agencies and the private sector. The latest updates on National Laboratory implementation will also be provided in this presentation. At the same time as these significant increases in scientific capability, there have been significant ongoing accomplishments in NASA's early ISS research both exploration related and fundamental research. These accomplishments will be reviewed in context as harbingers of the capabilities of the International Space Station when assembly is complete. The Vision for Space Exploration serves to focus NASA's applied investigations in the physical sciences. However, the broader capability of the space station as a National Laboratory and as a nexus for international collaboration will also influence the study of gravity-dependent processes by researchers around the world.

  14. Similarities between decapod and insect neuropeptidomes

    PubMed Central

    2016-01-01

    Background. Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts. Methods. The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed to construct contigs encoding the neuropeptide precursors as completely as possible. Results. The seven decapod species analyzed in this fashion, the crabs Eriocheir sinensis, Carcinus maenas and Scylla paramamosain, the shrimp Litopenaeus vannamei, the lobster Homarus americanus, the fresh water prawn Macrobrachium rosenbergii and the crayfish Procambarus clarkii had remarkably similar neuropeptidomes. Although some neuropeptide precursors could not be assembled, in many cases individual reads pertaining to the missing precursors show unambiguously that these neuropeptides are present in these species. In other cases, the tissues that express those neuropeptides were not used in the construction of the cDNA libraries. One novel neuropeptide was identified: elongated PDH (pigment dispersing hormone), a variation on PDH that has a two-amino-acid insertion in its core sequence. Hyrg is another peptide that is ubiquitously present in decapods and is likely a novel neuropeptide precursor. Discussion. Many insect species have lost one or more neuropeptide genes, but apart from elongated PDH and hyrg all other decapod neuropeptides are present in at least some insect species, and allatotropin is the only insect neuropeptide missing from decapods. This strong similarity between insect and decapod neuropeptidomes makes it possible to predict the receptors for decapod neuropeptides

  15. Similarities between decapod and insect neuropeptidomes.

    PubMed

    Veenstra, Jan A

    2016-01-01

    Background. Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts. Methods. The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed to construct contigs encoding the neuropeptide precursors as completely as possible. Results. The seven decapod species analyzed in this fashion, the crabs Eriocheir sinensis, Carcinus maenas and Scylla paramamosain, the shrimp Litopenaeus vannamei, the lobster Homarus americanus, the fresh water prawn Macrobrachium rosenbergii and the crayfish Procambarus clarkii had remarkably similar neuropeptidomes. Although some neuropeptide precursors could not be assembled, in many cases individual reads pertaining to the missing precursors show unambiguously that these neuropeptides are present in these species. In other cases, the tissues that express those neuropeptides were not used in the construction of the cDNA libraries. One novel neuropeptide was identified: elongated PDH (pigment dispersing hormone), a variation on PDH that has a two-amino-acid insertion in its core sequence. Hyrg is another peptide that is ubiquitously present in decapods and is likely a novel neuropeptide precursor. Discussion. Many insect species have lost one or more neuropeptide genes, but apart from elongated PDH and hyrg all other decapod neuropeptides are present in at least some insect species, and allatotropin is the only insect neuropeptide missing from decapods. This strong similarity between insect and decapod neuropeptidomes makes it possible to predict the receptors for decapod neuropeptides

  16. Similarities between decapod and insect neuropeptidomes.

    PubMed

    Veenstra, Jan A

    2016-01-01

    Background. Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts. Methods. The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed to construct contigs encoding the neuropeptide precursors as completely as possible. Results. The seven decapod species analyzed in this fashion, the crabs Eriocheir sinensis, Carcinus maenas and Scylla paramamosain, the shrimp Litopenaeus vannamei, the lobster Homarus americanus, the fresh water prawn Macrobrachium rosenbergii and the crayfish Procambarus clarkii had remarkably similar neuropeptidomes. Although some neuropeptide precursors could not be assembled, in many cases individual reads pertaining to the missing precursors show unambiguously that these neuropeptides are present in these species. In other cases, the tissues that express those neuropeptides were not used in the construction of the cDNA libraries. One novel neuropeptide was identified: elongated PDH (pigment dispersing hormone), a variation on PDH that has a two-amino-acid insertion in its core sequence. Hyrg is another peptide that is ubiquitously present in decapods and is likely a novel neuropeptide precursor. Discussion. Many insect species have lost one or more neuropeptide genes, but apart from elongated PDH and hyrg all other decapod neuropeptides are present in at least some insect species, and allatotropin is the only insect neuropeptide missing from decapods. This strong similarity between insect and decapod neuropeptidomes makes it possible to predict the receptors for decapod neuropeptides

  17. Similarity Rules for Scaling Solar Sail Systems

    NASA Technical Reports Server (NTRS)

    Canfield, Stephen L.; Peddieson, John; Garbe, Gregory

    2010-01-01

    Future science missions will require solar sails on the order of 200 square meters (or larger). However, ground demonstrations and flight demonstrations must be conducted at significantly smaller sizes, due to limitations of ground-based facilities and cost and availability of flight opportunities. For this reason, the ability to understand the process of scalability, as it applies to solar sail system models and test data, is crucial to the advancement of this technology. This paper will approach the problem of scaling in solar sail models by developing a set of scaling laws or similarity criteria that will provide constraints in the sail design process. These scaling laws establish functional relationships between design parameters of a prototype and model sail that are created at different geometric sizes. This work is applied to a specific solar sail configuration and results in three (four) similarity criteria for static (dynamic) sail models. Further, it is demonstrated that even in the context of unique sail material requirements and gravitational load of earth-bound experiments, it is possible to develop appropriate scaled sail experiments. In the longer term, these scaling laws can be used in the design of scaled experimental tests for solar sails and in analyzing the results from such tests.

  18. Similarity and confidence in artificial grammar learning.

    PubMed

    Tunney, Richard J

    2010-01-01

    Three experiments examined the relationship between similarity ratings and confidence ratings in artificial grammar learning. In Experiment 1 participants rated the similarity of test items to study exemplars. Regression analyses revealed these to be related to some of the objective measures of similarity that have previously been implicated in categorization decisions. In Experiment 2 participants made grammaticality decisions and rated either their confidence in the accuracy of their decisions or the similarity of the test items to the study items. Regression analyses showed that the grammaticality decisions were predicted by the similarity ratings obtained in Experiment 1. Points on the receiver operating characteristics (ROC) curves for the similarity and confidence ratings were closely matched. These data suggest that meta-cognitive judgments of confidence are predicated on structural knowledge of similarity. Experiment 3 confirmed this by showing that confidence ratings to median similarity probe items changed according to the similarity of preceding items.

  19. Visual similarity effects in categorical search.

    PubMed

    Alexander, Robert G; Zelinsky, Gregory J

    2011-07-14

    We asked how visual similarity relationships affect search guidance to categorically defined targets (no visual preview). Experiment 1 used a web-based task to collect visual similarity rankings between two target categories, teddy bears and butterflies, and random-category objects, from which we created search displays in Experiment 2 having either high-similarity distractors, low-similarity distractors, or "mixed" displays with high-, medium-, and low-similarity distractors. Analysis of target-absent trials revealed faster manual responses and fewer fixated distractors on low-similarity displays compared to high-similarity displays. On mixed displays, first fixations were more frequent on high-similarity distractors (bear = 49%; butterfly = 58%) than on low-similarity distractors (bear = 9%; butterfly = 12%). Experiment 3 used the same high/low/mixed conditions, but now these conditions were created using similarity estimates from a computer vision model that ranked objects in terms of color, texture, and shape similarity. The same patterns were found, suggesting that categorical search can indeed be guided by purely visual similarity. Experiment 4 compared cases where the model and human rankings differed and when they agreed. We found that similarity effects were best predicted by cases where the two sets of rankings agreed, suggesting that both human visual similarity rankings and the computer vision model captured features important for guiding search to categorical targets.

  20. Towards accomplished practice in learning skills for science (LSS): the synergy between design and evaluation methodology in a reflective CPD programme

    NASA Astrophysics Data System (ADS)

    Scherz, Zahava; Bialer, Liora; Eylon, Bat-Sheva

    2011-04-01

    This study was carried out in the framework of continuous professional development (CPD) programmes following a CPD model aimed at promoting 'accomplished practice' involving: pedagogical knowledge, content knowledge, pedagogical content knowledge and scholarship of teaching. Teachers were asked to bring evidence about their practice. The context was related to the 'Learning Skills for Science' (LSS) programme, which advocates the explicit incorporation of high-order learning skills into science school curricula. The main goal of the study was to test the evidence-based LSS CPD model by investigating the impact of its related CPD programmes on participating teachers. The impact relates to teachers' perceptions about teaching learning skills, teachers' LSS practice, and their professional influence in the educational system. As part of the evaluation method, we developed a criterion-based diagnostic tool and a visual representation, designed to assess a teacher's professional profile and progression according to dimensions of 'accomplished practice'. The diagnostic tool can be adjusted and tailored to different CPD domains. Results indicated that requiring teachers to bring evidence from practice and students' learning enabled us to follow teachers' progress and succeeded to improve their performances towards accomplished LSS practice. The results exemplify a synergy between CPD designed activities and the ongoing evaluation of its impact.

  1. Structural dynamics division research and technology accomplishments for fiscal year 1990 and plans for fiscal year 1991

    NASA Technical Reports Server (NTRS)

    Wynne, Eleanor C.

    1991-01-01

    The research accomplishments of the Structural Dynamics Division for F.Y. 1991 are presented. The work is discussed in terms of highlights of accomplishments during the past year and plans for the current year as they relate to 5-year plans and the objectives of each technical area. Included is research on unsteady aerodynamics, helicopter rotors, computational fluid dynamics, oscillations of leading edge flaps of a delta wing, and aircraft wing loads.

  2. A Representational Similarity Analysis of the Dynamics of Object Processing Using Single-Trial EEG Classification

    PubMed Central

    Kaneshiro, Blair; Perreau Guimaraes, Marcos; Kim, Hyung-Suk; Norcia, Anthony M.

    2015-01-01

    The recognition of object categories is effortlessly accomplished in everyday life, yet its neural underpinnings remain not fully understood. In this electroencephalography (EEG) study, we used single-trial classification to perform a Representational Similarity Analysis (RSA) of categorical representation of objects in human visual cortex. Brain responses were recorded while participants viewed a set of 72 photographs of objects with a planned category structure. The Representational Dissimilarity Matrix (RDM) used for RSA was derived from confusions of a linear classifier operating on single EEG trials. In contrast to past studies, which used pairwise correlation or classification to derive the RDM, we used confusion matrices from multi-class classifications, which provided novel self-similarity measures that were used to derive the overall size of the representational space. We additionally performed classifications on subsets of the brain response in order to identify spatial and temporal EEG components that best discriminated object categories and exemplars. Results from category-level classifications revealed that brain responses to images of human faces formed the most distinct category, while responses to images from the two inanimate categories formed a single category cluster. Exemplar-level classifications produced a broadly similar category structure, as well as sub-clusters corresponding to natural language categories. Spatiotemporal components of the brain response that differentiated exemplars within a category were found to differ from those implicated in differentiating between categories. Our results show that a classification approach can be successfully applied to single-trial scalp-recorded EEG to recover fine-grained object category structure, as well as to identify interpretable spatiotemporal components underlying object processing. Finally, object category can be decoded from purely temporal information recorded at single electrodes. PMID

  3. A Representational Similarity Analysis of the Dynamics of Object Processing Using Single-Trial EEG Classification.

    PubMed

    Kaneshiro, Blair; Perreau Guimaraes, Marcos; Kim, Hyung-Suk; Norcia, Anthony M; Suppes, Patrick

    2015-01-01

    The recognition of object categories is effortlessly accomplished in everyday life, yet its neural underpinnings remain not fully understood. In this electroencephalography (EEG) study, we used single-trial classification to perform a Representational Similarity Analysis (RSA) of categorical representation of objects in human visual cortex. Brain responses were recorded while participants viewed a set of 72 photographs of objects with a planned category structure. The Representational Dissimilarity Matrix (RDM) used for RSA was derived from confusions of a linear classifier operating on single EEG trials. In contrast to past studies, which used pairwise correlation or classification to derive the RDM, we used confusion matrices from multi-class classifications, which provided novel self-similarity measures that were used to derive the overall size of the representational space. We additionally performed classifications on subsets of the brain response in order to identify spatial and temporal EEG components that best discriminated object categories and exemplars. Results from category-level classifications revealed that brain responses to images of human faces formed the most distinct category, while responses to images from the two inanimate categories formed a single category cluster. Exemplar-level classifications produced a broadly similar category structure, as well as sub-clusters corresponding to natural language categories. Spatiotemporal components of the brain response that differentiated exemplars within a category were found to differ from those implicated in differentiating between categories. Our results show that a classification approach can be successfully applied to single-trial scalp-recorded EEG to recover fine-grained object category structure, as well as to identify interpretable spatiotemporal components underlying object processing. Finally, object category can be decoded from purely temporal information recorded at single electrodes. PMID

  4. On the similarity of variable viscosity flows

    NASA Astrophysics Data System (ADS)

    Voivenel, L.; Danaila, L.; Varea, E.; Renou, B.; Cazalens, M.

    2016-08-01

    Turbulent mixing is ubiquitous in both nature and industrial applications. Most of them concern different fluids, therefore with variable physical properties (density and/or viscosity). The focus here is on variable viscosity flows and mixing, involving density-matched fluids. The issue is whether or not these flows may be self-similar, or self-preserving. The importance of this question stands on the predictability of these flows; self-similar dynamical systems are easier tractable from an analytical viewpoint. More specifically, self-similar analysis is applied to the scale-by-scale energy transport equations, which represent the transport of energy at each scale and each point of the flow. Scale-by-scale energy budget equations are developed for inhomogeneous and anisotropic flows, in which the viscosity varies as a result of heterogeneous mixture or temperature variations. Additional terms are highlighted, accounting for the viscosity gradients, or fluctuations. These terms are present at both small and large scales, thus rectifying the common belief that viscosity is a small-scale quantity. Scale-by-scale energy budget equations are then adapted for the particular case of a round jet evolving in a more viscous host fluid. It is further shown that the condition of self-preservation is not necessarily satisfied in variable-viscosity jets. Indeed, the jet momentum conservation, as well as the constancy of the Reynolds number in the central region of the jet, cannot be satisfied simultaneously. This points to the necessity of considering less stringent conditions (with respect to classical, single-fluid jets) when analytically tackling these flows and reinforces the idea that viscosity variations must be accounted for when modelling these flows.

  5. FRESCO: Referential compression of highly similar sequences.

    PubMed

    Wandelt, Sebastian; Leser, Ulf

    2013-01-01

    In many applications, sets of similar texts or sequences are of high importance. Prominent examples are revision histories of documents or genomic sequences. Modern high-throughput sequencing technologies are able to generate DNA sequences at an ever-increasing rate. In parallel to the decreasing experimental time and cost necessary to produce DNA sequences, computational requirements for analysis and storage of the sequences are steeply increasing. Compression is a key technology to deal with this challenge. Recently, referential compression schemes, storing only the differences between a to-be-compressed input and a known reference sequence, gained a lot of interest in this field. In this paper, we propose a general open-source framework to compress large amounts of biological sequence data called Framework for REferential Sequence COmpression (FRESCO). Our basic compression algorithm is shown to be one to two orders of magnitudes faster than comparable related work, while achieving similar compression ratios. We also propose several techniques to further increase compression ratios, while still retaining the advantage in speed: 1) selecting a good reference sequence; and 2) rewriting a reference sequence to allow for better compression. In addition,we propose a new way of further boosting the compression ratios by applying referential compression to already referentially compressed files (second-order compression). This technique allows for compression ratios way beyond state of the art, for instance,4,000:1 and higher for human genomes. We evaluate our algorithms on a large data set from three different species (more than 1,000 genomes, more than 3 TB) and on a collection of versions of Wikipedia pages. Our results show that real-time compression of highly similar sequences at high compression ratios is possible on modern hardware.

  6. Horton Law in Self-Similar Trees

    NASA Astrophysics Data System (ADS)

    Kovchegov, Yevgeniy; Zaliapin, Ilya

    2016-04-01

    Self-similarity of random trees is related to the operation of pruning. Pruning ℛ cuts the leaves and their parental edges and removes the resulting chains of degree-two nodes from a finite tree. A Horton-Strahler order of a vertex v and its parental edge is defined as the minimal number of prunings necessary to eliminate the subtree rooted at v. A branch is a group of neighboring vertices and edges of the same order. The Horton numbers 𝒩k[K] and 𝒩ij[K] are defined as the expected number of branches of order k, and the expected number of order-i branches that merged order-j branches, j > i, respectively, in a finite tree of order K. The Tokunaga coefficients are defined as Tij[K] = 𝒩ij[K]/𝒩j[K]. The pruning decreases the orders of tree vertices by unity. A rooted full binary tree is said to be mean-self-similar if its Tokunaga coefficients are invariant with respect to pruning: Tk := Ti,i+k[K]. We show that for self-similar trees, the condition limsupk→∞Tk1/k < ∞ is necessary and sufficient for the existence of the strong Horton law: 𝒩k[K]/𝒩1[K] → R1-k, as K →∞ for some R > 0 and every k ≥ 1. This work is a step toward providing rigorous foundations for the Horton law that, being omnipresent in natural branching systems, has escaped so far a formal explanation.

  7. FRESCO: Referential compression of highly similar sequences.

    PubMed

    Wandelt, Sebastian; Leser, Ulf

    2013-01-01

    In many applications, sets of similar texts or sequences are of high importance. Prominent examples are revision histories of documents or genomic sequences. Modern high-throughput sequencing technologies are able to generate DNA sequences at an ever-increasing rate. In parallel to the decreasing experimental time and cost necessary to produce DNA sequences, computational requirements for analysis and storage of the sequences are steeply increasing. Compression is a key technology to deal with this challenge. Recently, referential compression schemes, storing only the differences between a to-be-compressed input and a known reference sequence, gained a lot of interest in this field. In this paper, we propose a general open-source framework to compress large amounts of biological sequence data called Framework for REferential Sequence COmpression (FRESCO). Our basic compression algorithm is shown to be one to two orders of magnitudes faster than comparable related work, while achieving similar compression ratios. We also propose several techniques to further increase compression ratios, while still retaining the advantage in speed: 1) selecting a good reference sequence; and 2) rewriting a reference sequence to allow for better compression. In addition,we propose a new way of further boosting the compression ratios by applying referential compression to already referentially compressed files (second-order compression). This technique allows for compression ratios way beyond state of the art, for instance,4,000:1 and higher for human genomes. We evaluate our algorithms on a large data set from three different species (more than 1,000 genomes, more than 3 TB) and on a collection of versions of Wikipedia pages. Our results show that real-time compression of highly similar sequences at high compression ratios is possible on modern hardware. PMID:24524158

  8. Professional conceptualisation and accomplishment of patient safety in mental healthcare: an ethnographic approach

    PubMed Central

    2011-01-01

    Background This study seeks to broaden current understandings of what patient safety means in mental healthcare and how it is accomplished. We propose a qualitative observational study of how safety is produced or not produced in the complex context of everyday professional mental health practice. Such an approach intentionally contrasts with much patient safety research which assumes that safety is achieved and improved through top-down policy directives. We seek instead to understand and articulate the connections and dynamic interactions between people, materials, and organisational, legal, moral, professional and historical safety imperatives as they come together at particular times and places to perform safe or unsafe practice. As such we advocate an understanding of patient safety 'from the ground up'. Methods/Design The proposed project employs a six-phase data collection framework in two mental health settings: an inpatient unit and a community team. The first four phases comprise multiple modes of focussed, unobtrusive observation of professionals at work, to enable us to trace the conceptualisation and enactment of safety as revealed in dialogue and narrative, use of artefacts and space, bodily activity and patterns of movement, and in the accomplishment of specific work tasks. An interview phase and a social network analysis phase will subsequently be conducted to offer comparative perspectives on the observational data. This multi-modal and holistic approach to studying patient safety will complement existing research, which is dominated by instrumentalist approaches to discovering factors contributing to error, or developing interventions to prevent or manage adverse events. Discussion This ethnographic research framework, informed by the principles of practice theories and in particular actor-network ideas, provides a tool to aid the understanding of patient safety in mental healthcare. The approach is novel in that it seeks to articulate an 'anatomy

  9. Asthma and COPD: Differences and Similarities

    MedlinePlus

    ... and COPD: differences and similarities Share | Asthma and COPD: Differences and Similarities This article has been reviewed ... you could have asthma, or you could have Chronic Obstructive Pulmonary Disease (COPD) , such as emphysema or chronic bronchitis. Because ...

  10. Pharmacophore-Based Similarity Scoring for DOCK

    PubMed Central

    2015-01-01

    Pharmacophore modeling incorporates geometric and chemical features of known inhibitors and/or targeted binding sites to rationally identify and design new drug leads. In this study, we have encoded a three-dimensional pharmacophore matching similarity (FMS) scoring function into the structure-based design program DOCK. Validation and characterization of the method are presented through pose reproduction, crossdocking, and enrichment studies. When used alone, FMS scoring dramatically improves pose reproduction success to 93.5% (∼20% increase) and reduces sampling failures to 3.7% (∼6% drop) compared to the standard energy score (SGE) across 1043 protein–ligand complexes. The combined FMS+SGE function further improves success to 98.3%. Crossdocking experiments using FMS and FMS+SGE scoring, for six diverse protein families, similarly showed improvements in success, provided proper pharmacophore references are employed. For enrichment, incorporating pharmacophores during sampling and scoring, in most cases, also yield improved outcomes when docking and rank-ordering libraries of known actives and decoys to 15 systems. Retrospective analyses of virtual screenings to three clinical drug targets (EGFR, IGF-1R, and HIVgp41) using X-ray structures of known inhibitors as pharmacophore references are also reported, including a customized FMS scoring protocol to bias on selected regions in the reference. Overall, the results and fundamental insights gained from this study should benefit the docking community in general, particularly researchers using the new FMS method to guide computational drug discovery with DOCK. PMID:25229837

  11. Similarity and scale in catchment storm response

    NASA Technical Reports Server (NTRS)

    Wood, Eric F.; Sivapalan, Murugesu; Beven, Keith

    1993-01-01

    Until recently, very little progress had been made in understanding the relationship between small-scale variability of topography, soil, and rainfalls and the storm response seen at the catchment scale. The work reviewed here represents the first attempt at a systematic theoretical framework for such understanding in the context of surface runoff generation by different processes. The parameterization of hydrological processes over a range of scales is examined, and the concept of the 'representative elementary area' (REA) is introduced. The REA is a fundamental scale for catchment modeling at which continuum assumptions can be applied for the spatially variable controls and parameters, and spatial patterns no longer have to be considered explicitly. The investigation of scale leads into the concept of hydrologic similarity in which the effects of the environmental controls on runoff generation and flood frequency response be investigated independently of catchment scale. The paper reviews the authors' initial results and hopefully will motivate others to also investigate the issues of hydrologic scale and similarity.

  12. Modeling listener perception of speaker similarity in dysarthria.

    PubMed

    Lansford, Kaitlin L; Berisha, Visar; Utianski, Rene L

    2016-06-01

    The current investigation contributes to a perceptual similarity-based approach to dysarthria characterization by utilizing an innovative statistical approach, multinomial logistic regression with sparsity constraints, to identify acoustic features underlying each listener's impressions of speaker similarity. The data-driven approach also permitted an examination of the effect of clinical experience on listeners' impressions of similarity. Listeners, irrespective of level of clinical experience, were found to rely on similar acoustic features during the perceptual sorting task, known as free classification. Overall, the results support the continued advancement of a similarity-based approach to characterizing the communication disorders associated with dysarthria. PMID:27369174

  13. Thematic Relations Affect Similarity via Commonalities

    ERIC Educational Resources Information Center

    Golonka, Sabrina; Estes, Zachary

    2009-01-01

    Thematic relations are an important source of perceived similarity. For instance, the "rowing" theme of boats and oars increases their perceived similarity. The mechanism of this effect, however, has not been specified previously. The authors investigated whether thematic relations affect similarity by increasing commonalities or by decreasing…

  14. From compliance to concordance: barriers to accomplishing a re-framed model of health care interactions.

    PubMed

    Bissell, Paul; May, Carl R; Noyce, Peter R

    2004-02-01

    As a framework for organising health care interactions, compliance and adherence have come in for increasing criticism in recent years. It has been suggested that interactions with patients should not be viewed simply as opportunities to reinforce instructions around treatment: rather, they should be seen as a space where the expertise of patients and health professionals can be pooled to arrive at mutually agreed goals. This concept-known as concordance-is attracting increasing interest in health services research within the UK. In this paper, we seek to empirically explore the relevance of a re-framed consultation through qualitative interviews with a small group of English speaking patients of Pakistani origin with a diagnosis of type 2 diabetes. We suggest that the focus of many respondents in this study on material and structural factors limiting diabetic regimen integration and the emphasis on a 'doctor-centred' model of health care interactions represent distinct problems for the accomplishment of the concordance project. However, given that some patients sought greater understanding and appreciation by health professionals of the subjective aspects of living with diabetes, if it is evaluated at the level of health care relationships, rather than health outcomes (such as improved compliance) concordance may well be a significant development for those who suggest that respect for the patients agenda is a fundamental aspect of health care.

  15. Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle.

    PubMed

    Sze, Ching Wooen; Zhang, Kai; Kariu, Toru; Pal, Utpal; Li, Chunhao

    2012-07-01

    Borrelia burgdorferi, the causative agent of Lyme disease, can be recovered from different organs of infected animals and patients, indicating that the spirochete is very invasive. Motility and chemotaxis contribute to the invasiveness of B. burgdorferi and play important roles in the process of the disease. Recent reports have shown that motility is required for establishing infection in mammals. However, the role of chemotaxis in virulence remains elusive. Our previous studies showed that cheA₂, a gene encoding a histidine kinase, is essential for the chemotaxis of B. burgdorferi. In this report, the cheA₂ gene was inactivated in a low-passage-number virulent strain of B. burgdorferi. In vitro analyses (microscopic observations, computer-based bacterial tracking analysis, swarm plate assays, and capillary tube assays) showed that the cheA₂ mutant failed to reverse and constantly ran in one direction; the mutant was nonchemotactic to attractants. Mouse needle infection studies showed that the cheA₂ mutant failed to infect either immunocompetent or immunodeficient mice and was quickly eliminated from the initial inoculation sites. Tick-mouse infection studies revealed that although the mutant was able to survive in ticks, it failed to establish a new infection in mice via tick bites. The altered phenotypes were completely restored when the mutant was complemented. Collectively, these data demonstrate that B. burgdorferi needs chemotaxis to establish mammalian infection and to accomplish its natural enzootic cycle.

  16. International Space Station Research for the Next Decade: International Coordination and Research Accomplishments

    NASA Technical Reports Server (NTRS)

    Thumm, Tracy L.; Robinson, Julie A.; Johnson-Green, Perry; Buckley, Nicole; Karabadzhak, George; Nakamura, Tai; Sorokin, Igor V.; Zell, Martin; Sabbagh, Jean

    2011-01-01

    During 2011, the International Space Station reached an important milestone in the completion of assembly and the shift to the focus on a full and continuous utilization mission in space. The ISS partnership itself has also met a milestone in the coordination and cooperation of utilization activities including research, technology development and education. We plan and track all ISS utilization activities jointly and have structures in place to cooperate on common goals by sharing ISS assets and resources, and extend the impacts and efficiency of utilization activities. The basic utilization areas on the ISS include research, technology development and testing, and education/outreach. Research can be categorized as applied research for future exploration, basic research taking advantage of the microgravity and open space environment, and Industrial R&D / commercial research focused at industrial product development and improvement. Technology development activities range from testing of new spacecraft systems and materials to the use of ISS as an analogue for future exploration missions to destinations beyond Earth orbit. This presentation, made jointly by all ISS international partners, will highlight the ways that international cooperation in all of these areas is achieved, and the overall accomplishments that have come as well as future perspectives from the cooperation. Recently, the partnership has made special efforts to increase the coordination and impact of ISS utilization that has humanitarian benefits. In this context the paper will highlight tentative ISS utilization developments in the areas of Earth remote sensing, medical technology transfer, and education/outreach.

  17. Stem cells clinical trials for cardiac repair: regulation as practical accomplishment.

    PubMed

    Wilson-Kovacs, Dana M; Weber, Susanne; Hauskeller, Christine

    2010-01-01

    Macro-analyses on the regulation of new biomedical objects tend to focus on discursive structures and legislative categories in science policy debates at national and cross-national levels, but overlook how actors engage in regulatory practices on an everyday basis. Based on data from ethnographic fieldwork in British and German clinics, and 32 interviews with medical staff, this article provides an insight into the regulation of adult stem cell research and its clinical implementation. The argument illustrates the enactment of regulation at different stages and highlights the accompanying interpretative strategies employed by the medical personnel involved in the management of clinical trials using patients' own (autologous) stem cells to regenerate damaged cardiac tissue. We argue that the implementation of regulation is a practical accomplishment in both national contexts. The complexities present in this process are instanced by the gradual crystallisation of practices within the organisation of clinical trials. This crystallisation is dependent on exchanges between members of medical teams and external agencies, and is set within a strategic ordering of regulatory measures that are mobilised to legitimise clinical research and reinforce professional interests.

  18. The ICES Working Group on Zooplankton Ecology: Accomplishments of the first 25 years

    NASA Astrophysics Data System (ADS)

    Wiebe, Peter H.; Harris, Roger; Gislason, Astthor; Margonski, Piotr; Skjoldal, Hein Rune; Benfield, Mark; Hay, Steve; O'Brien, Todd; Valdés, Luis

    2016-02-01

    The ICES Study Group on Zooplankton Ecology was created in 1991 to address issues of current and future concern within the field of zooplankton ecology. Within three years it became the ICES Working Group on Zooplankton Ecology (ICES WGZE) and this unique group in the world's oceanographic community has now been active for 25 years. This article reviews and synthesizes the products, and major accomplishments of the group. Achievements of the group, including the Zooplankton Methodology Manual, the Zooplankton Status Reports, and the International Zooplankton Symposia, have had an important impact on the wider field. Among the future issues that remain to be addressed by the group are the assessment of exploratory fisheries on zooplankton and micronekton species; further development of the zooplankton time-series; compilation and integration of allometric relationships for zooplankton species, and evaluation of new methodologies for the study of zooplankton distribution, abundance, physiology, and genetics. Marine science is an increasingly global undertaking and groups such as the ICES WGZE will continue to be essential to the advancement of understanding of zooplankton community structure and population dynamics in the world's oceans.

  19. Program accomplishments and future prospects for low-temperature geothermal resource assessment in New Mexico

    SciTech Connect

    Icerman, L.; Ruscetta, C.A.

    1982-07-01

    An important component of the State-coupled program has been basic studies in specific regions of New Mexico, including areas adjacent to the cities of Albuquerque, Las Cruces, Socorro, and Truth or Consequences. Considerable geological, hydrological, electrical resistivity, gravity, magnetic, seismic, water analysis, and subsurface temperature data have been compiled and analyzed for these locations. During the four-year research program, a total of 25 tasks have been undertaken. Eleven of these tasks were focused toward collecting and compiling statewide data, six were regional studies covering more than one county, and eight were research projects directed primarily toward data collection near specific cities or known resource areas. Two of these latter studies contributed significantly to the confirmation of the Las Alturas geothermal anomaly east of Las Cruces. A brief summary of the program accomplishments by task is presented. The resource assessment programs in New Mexico have been very successful in (1) delineating low-temperature geothermal resources throughout New Mexico on statewide, regional, and area-specific scales; (2) developing a strong community of in-state geothermal energy research and development professionals and practitioners; and (3) elevating the level of awareness of geothermal energy potential among commerce, industry, and the general public. Future prospects for the state are presented.

  20. Task III: UCSD/DIII-D/Textor FY-97-98 Accomplishments

    SciTech Connect

    Boedo, J.A.

    2000-09-05

    OAK (B204) Task III: UCSD/DIII-D/Textor FY-97-98 Accomplishments. A comprehensive report on the physics of pump limiters and particularly, the characterization of ALT-II, was published in Nuclear Fusion, bringing the project to a closure. The performance of the toroidal pump limiter was characterized under full auxiliary heating of 7 MW of NBI and ICRH and full pumping, as stated in the project milestones. Relevant highlights are: (1) Pumping with ALT-II allows for density control. (2) The achieved exhaust efficiency is 4% during NBI operation and near 2% during OH or ICRH operation. (3) We have shown that an exhaust efficiency of 2% is sufficient to satisfy the ash removal requirements of fusion reactors. (4) The plasma particle efflux and the pumped flux both increase with density and heating power. (5) The particle confinement time is less than the energy confinement time by a factor of 4. In summary, pumped belt limiters could provide the density control and ash exhaust requirements of fusion reactors.

  1. U.S. Spacesuit Knowledge Capture Accomplishments in Fiscal Years 2012 and 2013

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Oliva, Vladenka R.

    2014-01-01

    The NASA U.S. spacesuit knowledge capture (KC) program has been in operations since the beginning 2008. The program was designed to augment engineers and others with information about spacesuits in a historical way. A multitude of seminars have captured spacesuit history and knowledge over the last six years of the programs existence. Subject matter experts have provided lectures and were interviewed to help bring the spacesuit to life so that lessons learned will never be lost. As well, the program concentrated in reaching out to the public and industry by making the recorded events part of the public domain through the NASA technical library via You Tube media. The U.S. spacesuit KC topics have included lessons learned from some of the most prominent spacesuit experts and spacesuit users including current and former astronauts. The events have enriched the spacesuit legacy knowledge from Gemini, Apollo, Skylab, Space Shuttle and International Space Station Programs. As well, expert engineers and scientists have shared their challenges and successes to be remembered. The last few years have been some of the most successful years of the KC program program's life with numerous recordings and releases to the public. It is evidenced by the thousands that have view the recordings online. This paper reviews the events accomplished and archived over Fiscal Years 2012 and 2013 and highlights a few of the most memorable ones. This paper also communicates ways to access the events that are available internally to NASA as well as in the public domain.

  2. AIRS Science Accomplishments Version 4.0/Plans for Version 5

    NASA Technical Reports Server (NTRS)

    Pagano, Thomas S.; Aumann, Hartmut; Elliott, Denis; Granger, Stephanie; Kahn, Brain; Eldering, Annmarie; Irion, Bill; Fetzer, Eric; Olsen, Ed; Lee, Sung-Yung; Okonek, Sharon; Friedman, Steve; Fishbein, Evan; Gaiser, Steve

    2006-01-01

    This talk is about accomplishments with AIRS data and what we have learned from almost three years of data what part of this is emerging in Version 4.0 what part we would like to see filtering into Version 5.0 and what part constitute limitations in the AIRS requirements, such as spectral and spatial resolution, which have to be deferred to the wish list for the next generation hyperspectral sounder. The AIRS calibration accuracy at the 1OOmK and stability at the 6 mK/year level are amazing. It establishes the unique capability of a cooled grating array spectrometer in Earth orbit for climate research. Data which are sufficiently clear to match the radiometric accuracy of the instrument, have a yield of less than 1%. This is OK for calibration. The 2616/cm window channel combined with the RTG.SST for tropical ocean allow excellent assessment radiometric calibration accuracy and stability. For absolute calibration verification 100mK is the limit due to cloud contamination. The 10 micron window channels can be used for stability assessment, but accuracy is limited at 300mK due to water continuum absorption uncertainties.

  3. Serving two (or more) masters: accomplishing autonomous nursing practice in chronic disease management.

    PubMed

    Kimpson, Sally; Purkis, Mary E

    2011-07-01

    The concept of professional autonomy has figured prominently in literature that addresses nursing's project of professionalization. Nursing's capacity to determine the nature and scope of its practice is related in important ways to the location of practice. Within highly structured environments such as acute-care hospitals, nurses' professional autonomy has frequently been contested yet is often implicated by nursing's elite as a necessary condition in the construction of quality work environments. Professional concerns and management practices related to retaining experienced nurses to support sustainability in healthcare delivery systems' impact on the ability of nurses to practice autonomously. Our paper focuses on the emerging field of practice of chronic disease management. We describe the complex relationships negotiated by a nurse in a theoretically autonomous practice setting as she seeks to fulfil both the requirements of a research protocol designed by physician experts representing the specialty of renal medicine, and her professional obligations to respond to the expressed needs of patients with early-stage renal disease. We utilize a case study approach to explore particular contemporary concerns that nurses in practice confront as they attempt to accomplish professional relationships with patients central to achieving prescribed medical outcomes where nursing practice, as an element of the achievement of those outcomes, is constituted as absent or unacknowledged by the medical researchers leading the project. Implications for nursing's discourses on the professional project of autonomy will be discussed.

  4. Fifteen Years of Earth Observations from MODIS: What Has Been Accomplished?

    NASA Astrophysics Data System (ADS)

    King, M. D.; Running, S. W.; Platnick, S. E.; Franz, B. A.

    2014-12-01

    The Moderate Resolution Imaging Spectroradiometer (MODIS) was developed by NASA and launched onboard the Terra spacecraft on December 18, 1999 and Aqua spacecraft on May 4, 2002. It achieved its final orbit and began Earth observations on February 24, 2000 for Terra and June 24, 2002 for Aqua. Among the remote sensing algorithms developed and applied to this sensor for nearly 15 years of Earth observations are spectral and spatial distribution of albedo and surface reflectance, snow and sea ice mapping, land cover and vegetation index, fire products, including burn scars, cloud amount, cloud and aerosol optical properties, sea surface temperature, and ocean color. The archived products from these algorithms have applications in climate change studies, climate modeling, numerical weather prediction, biogeochemistry studies, and fundamental atmospheric research. A sampling of what has been accomplished and the breadth of new, often unanticipated, applications will be highlighted and discussed. Many of the MODIS products have already been adopted by agencies concerned with natural resource and environmental management.

  5. Research accomplishments and future goals in particle physics. Final technical report

    SciTech Connect

    Not Available

    1994-06-01

    This proposal presents the research accomplishments and ongoing activities of Boston University researchers in high energy physics. Some changes have been made in the structure of the program from the previous arrangement of tasks. Task B, Accelerator Design Physics, is being submitted as a separate proposal for an independent grant; this will be consistent with the nature of the research and the source of funding. Boston University is active in seven principal areas: (1) Task A: Colliding Beams -- physics of e{sup +}e{sup {minus}} and {anti p}p collisions; (2) Task C: MACRO Experiment -- search for magnetic monopoles and study of cosmic rays; (3) Task D: Proton Decay -- search for nucleon instability and study of neutrino interactions; (4) Tasks E, J, and N: Particle Theory -- theoretical high energy particle physics, including two Outstanding Junior Investigator awards; (5) Task F: Muon G-2 -- measurement of the anomalous magnetic moment of the muon; (6) Task K: SSCintcal -- calorimetry for the GEM Experiment; (7) Task L: Muon Detectors for the GEM Experiment. The body of the proposal is devoted to detailed discussions of each of the tasks. The total budget request for the program appears in a summary chapter that includes a general budget discussion and individual budget requests and explanations for each of the tasks.

  6. US CLIVAR Accomplishments Over the Past 15 Years and Research Challenges for the Future

    NASA Astrophysics Data System (ADS)

    Uhlenbrock, K.; Patterson, M. W.

    2014-12-01

    The US Climate Variability and Predictability Program (CLIVAR) has brought meaningful contributions to the understanding of the role the ocean plays in the global climate system since its launch in 1998. By fostering community-based planning and implementation, US CLIVAR has made strides in increasing our understanding of the climate system and its predictability. Key accomplishments include a better understanding of intraseasonal-to-centennial timescales, expansion of a sustained ocean observing system for monitoring and assessing climate variability and change, improved understanding of critical physical processes and their representation in climate and Earth system models, and coordinated inter-comparisons of ocean and coupled simulations that have led to improved predictive capability. Building upon these advancements, the new US CLIVAR Science Plan presents revised goals, strategies, and research challenges that emphasize strengthened ties to the broader Earth science community and relevance to societal impacts. We will highlight the scope and priorities for each of the following four research challenges: (i) decadal variability and predictability; (ii) climate and extreme events; (iii) polar climate; and (iv) climate and ocean biogeochemistry. We will also provide information on how scientists can participate in future planning and implementation activities.

  7. Similarities between protein folding and granular jamming

    PubMed Central

    Jose, Prasanth P; Andricioaei, Ioan

    2012-01-01

    Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we demonstrate that folded proteins exhibit signatures common to both glassiness and jamming by using temperature- and force-unfolding molecular dynamics simulations. Upon folding, proteins develop a peak in the interatomic force distributions that falls on a universal curve with experimentally measured forces on jammed grains and droplets. Dynamical signatures are found as a dramatic slowdown of stress relaxation upon folding. Together with granular similarities, folding is tied not just to the jamming transition, but a more nuanced picture of anisotropy, preparation protocol and internal interactions emerges. Results have implications for designing stable polymers and can open avenues to link protein folding to jamming theory. PMID:23093180

  8. Self similar evolution of evaporative supernova remnants

    NASA Astrophysics Data System (ADS)

    Chieze, J. P.; Lazareff, B.

    1981-02-01

    The expansion of a supernova remnant into an inhomogeneous medium of evaporating clouds can be idealized as a self-similar problem. The equations are set up and solved in the two limiting cases of negligible and dominant large scale conductivity, in the presence of an ad hoc external intercloud density equal to the product of Gamma, a parameter dependent on the evaporation parameter and the energy deposited by the supernova, with the -5/3 power of the radial distance, with Gamma equals 0 as a limiting case. While the detailed structure depends on Gamma, the global properties such as the expansion law and the total mass are to a large extent independent of this parameter, and agree with previous approximate results of McKee and Ostriker (1977). The limitations of the formal solutions are briefly discussed.

  9. Social values as arguments: similar is convincing

    PubMed Central

    Maio, Gregory R.; Hahn, Ulrike; Frost, John-Mark; Kuppens, Toon; Rehman, Nadia; Kamble, Shanmukh

    2014-01-01

    Politicians, philosophers, and rhetors engage in co-value argumentation: appealing to one value in order to support another value (e.g., “equality leads to freedom”). Across four experiments in the United Kingdom and India, we found that the psychological relatedness of values affects the persuasiveness of the arguments that bind them. Experiment 1 found that participants were more persuaded by arguments citing values that fulfilled similar motives than by arguments citing opposing values. Experiments 2 and 3 replicated this result using a wider variety of values, while finding that the effect is stronger among people higher in need for cognition and that the effect is mediated by the greater plausibility of co-value arguments that link motivationally compatible values. Experiment 4 extended the effect to real-world arguments taken from political propaganda and replicated the mediating effect of argument plausibility. The findings highlight the importance of value relatedness in argument persuasiveness. PMID:25147529

  10. Correlation between gene expression and GO semantic similarity.

    PubMed

    Sevilla, José L; Segura, Víctor; Podhorski, Adam; Guruceaga, Elizabeth; Mato, José M; Martínez-Cruz, Luis A; Corrales, Fernando J; Rubio, Angel

    2005-01-01

    This research analyzes some aspects of the relationship between gene expression, gene function, and gene annotation. Many recent studies are implicitly based on the assumption that gene products that are biologically and functionally related would maintain this similarity both in their expression profiles as well as in their Gene Ontology (GO) annotation. We analyze how accurate this assumption proves to be using real publicly available data. We also aim to validate a measure of semantic similarity for GO annotation. We use the Pearson correlation coefficient and its absolute value as a measure of similarity between expression profiles of gene products. We explore a number of semantic similarity measures (Resnik, Jiang, and Lin) and compute the similarity between gene products annotated using the GO. Finally, we compute correlation coefficients to compare gene expression similarity against GO semantic similarity. Our results suggest that the Resnik similarity measure outperforms the others and seems better suited for use in Gene Ontology. We also deduce that there seems to be correlation between semantic similarity in the GO annotation and gene expression for the three GO ontologies. We show that this correlation is negligible up to a certain semantic similarity value; then, for higher similarity values, the relationship trend becomes almost linear. These results can be used to augment the knowledge provided by clustering algorithms and in the development of bioinformatic tools for finding and characterizing gene products.

  11. The Aviation System Monitoring and Modeling (ASMM) Project: A Documentation of its History and Accomplishments: 1999-2005

    NASA Technical Reports Server (NTRS)

    Statler, Irving C. (Editor)

    2007-01-01

    The Aviation System Monitoring and Modeling (ASMM) Project was one of the projects within NASA s Aviation Safety Program from 1999 through 2005. The objective of the ASMM Project was to develop the technologies to enable the aviation industry to undertake a proactive approach to the management of its system-wide safety risks. The ASMM Project entailed four interdependent elements: (1) Data Analysis Tools Development - develop tools to convert numerical and textual data into information; (2) Intramural Monitoring - test and evaluate the data analysis tools in operational environments; (3) Extramural Monitoring - gain insight into the aviation system performance by surveying its front-line operators; and (4) Modeling and Simulations - provide reliable predictions of the system-wide hazards, their causal factors, and their operational risks that may result from the introduction of new technologies, new procedures, or new operational concepts. This report is a documentation of the history of this highly successful project and of its many accomplishments and contributions to improved safety of the aviation system.

  12. Investigating materials for breast nodules simulation by using segmentation and similarity analysis of digital images

    NASA Astrophysics Data System (ADS)

    Siqueira, Paula N.; Marcomini, Karem D.; Sousa, Maria A. Z.; Schiabel, Homero

    2015-03-01

    The task of identifying the malignancy of nodular lesions on mammograms becomes quite complex due to overlapped structures or even to the granular fibrous tissue which can cause confusion in classifying masses shape, leading to unnecessary biopsies. Efforts to develop methods for automatic masses detection in CADe (Computer Aided Detection) schemes have been made with the aim of assisting radiologists and working as a second opinion. The validation of these methods may be accomplished for instance by using databases with clinical images or acquired through breast phantoms. With this aim, some types of materials were tested in order to produce radiographic phantom images which could characterize a good enough approach to the typical mammograms corresponding to actual breast nodules. Therefore different nodules patterns were physically produced and used on a previous developed breast phantom. Their characteristics were tested according to the digital images obtained from phantom exposures at a LORAD M-IV mammography unit. Two analysis were realized the first one by the segmentation of regions of interest containing the simulated nodules by an automated segmentation technique as well as by an experienced radiologist who has delineated the contour of each nodule by means of a graphic display digitizer. Both results were compared by using evaluation metrics. The second one used measure of quality Structural Similarity (SSIM) to generate quantitative data related to the texture produced by each material. Although all the tested materials proved to be suitable for the study, the PVC film yielded the best results.

  13. Similarity increases altruistic punishment in humans.

    PubMed

    Mussweiler, Thomas; Ockenfels, Axel

    2013-11-26

    Humans are attracted to similar others. As a consequence, social networks are homogeneous in sociodemographic, intrapersonal, and other characteristics--a principle called homophily. Despite abundant evidence showing the importance of interpersonal similarity and homophily for human relationships, their behavioral correlates and cognitive foundations are poorly understood. Here, we show that perceived similarity substantially increases altruistic punishment, a key mechanism underlying human cooperation. We induced (dis)similarity perception by manipulating basic cognitive mechanisms in an economic cooperation game that included a punishment phase. We found that similarity-focused participants were more willing to punish others' uncooperative behavior. This influence of similarity is not explained by group identity, which has the opposite effect on altruistic punishment. Our findings demonstrate that pure similarity promotes reciprocity in ways known to encourage cooperation. At the same time, the increased willingness to punish norm violations among similarity-focused participants provides a rationale for why similar people are more likely to build stable social relationships. Finally, our findings show that altruistic punishment is differentially involved in encouraging cooperation under pure similarity vs. in-group conditions. PMID:24218611

  14. Psychophysical similarity measure based on multi-dimensional scaling for retrieval of similar images of breast masses on mammograms

    NASA Astrophysics Data System (ADS)

    Nishimura, Kohei; Muramatsu, Chisako; Oiwa, Mikinao; Shiraiwa, Misaki; Endo, Tokiko; Doi, Kunio; Fujita, Hiroshi

    2013-02-01

    For retrieving reference images which may be useful to radiologists in their diagnosis, it is necessary to determine a reliable similarity measure which would agree with radiologists' subjective impression. In this study, we propose a new similarity measure for retrieval of similar images, which may assist radiologists in the distinction between benign and malignant masses on mammograms, and investigated its usefulness. In our previous study, to take into account the subjective impression, the psychophysical similarity measure was determined by use of an artificial neural network (ANN), which was employed to learn the relationship between radiologists' subjective similarity ratings and image features. In this study, we propose a psychophysical similarity measure based on multi-dimensional scaling (MDS) in order to improve the accuracy in retrieval of similar images. Twenty-seven images of masses, 3 each from 9 different pathologic groups, were selected, and the subjective similarity ratings for all possible 351 pairs were determined by 8 expert physicians. MDS was applied using the average subjective ratings, and the relationship between each output axis and image features was modeled by the ANN. The MDS-based psychophysical measures were determined by the distance in the modeled space. With a leave-one-out test method, the conventional psychophysical similarity measure was moderately correlated with subjective similarity ratings (r=0.68), whereas the psychophysical measure based on MDS was highly correlated (r=0.81). The result indicates that a psychophysical similarity measure based on MDS would be useful in the retrieval of similar images.

  15. U.S. Spacesuit Knowledge Capture Accomplishments in Fiscal Years 2012 and 2013

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Oliva, Vladenka R.

    2014-01-01

    The NASA U.S. Spacesuit Knowledge Capture (KC) program has existed since the beginning of 2008. The program was designed to augment engineers and other technical team members with historical spacesuit information to add to their understanding of the spacesuit, its evolution, its limitations, and its capabilities. Over 40 seminars have captured spacesuit history and knowledge over the last six years of the program's existence. Subject matter experts have provided lectures and some were interviewed to help bring the spacesuit to life so that lessons learned will never be lost. As well, the program concentrated in reaching out to the public and industry by making the recorded events part of the public domain through the NASA technical library through YouTube media. The U.S. Spacesuit KC topics have included lessons learned from some of the most prominent spacesuit experts and spacesuit users including current and former astronauts. The events have enriched the spacesuit legacy knowledge from Gemini, Apollo, Skylab, Space Shuttle and International Space Station Programs. As well, expert engineers and scientists have shared their challenges and successes to be remembered. Based on evidence by the thousands of people who have viewed the recordings online, the last few years have been some of the most successful years of the KC program's life with numerous digital recordings and public releases. This paper reviews the events accomplished and archived over Fiscal Years 2012 and 2013 and highlights a few of the most memorable ones. This paper also communicates ways to access the events that are available internally on the NASA domain as well as those released on the public domain.

  16. NASA's In-Situ Resource Utilization Project: Current Accomplishments and Exciting Future Plans

    NASA Technical Reports Server (NTRS)

    Larson, William E.; Sanders, Gerald B.; Sacksteder, Kurt R.

    2010-01-01

    The utilization of Space resources has been identified in publications for over 40 years for its potential as a "game changing" technology for the human exploration of Space. It is called "game changing" because of the mass leverage possible when local resources at the exploration destination arc used to reduce or even eliminate resources that are brought from the Earth. NASA, under the Exploration Technology Development Program has made significant investments in the development of Space resource utilization technologies as a part of the In-Situ Resource Utilization (ISRU) project. Over the last four years, the ISRU project has taken what was essentially an academic topic with lots of experimentation but little engineering and produced near-full-scale systems that have been demonstrated. In 2008 & again in early 2010, systems that could produce oxygen from lunar soils (or their terrestrial analogs) were tested at a lunar analog site on a volcano in Hawaii. These demonstrations included collaborations with International Partners that made significant contributions to the tests. The proposed federal budget for Fiscal Year 2011 encourages the continued development and demonstration of ISRU. However it goes beyond what the project is currently doing and directs that the scope of the project be expanded to cover destinations throughout the inner solar system with the potential for night demonstrations. This paper will briefly cover the past accomplishments of the ISRU project then move to a di scussion of the plans for the project's future as NASA moves to explore a new paradigm for Space Exploration that includes orbital fuel depots and even refueling on other planetary bodies in the solar system.

  17. A new model for recognizing and rewarding the educational accomplishments of surgery faculty.

    PubMed

    Sachdeva, A K; Cohen, R; Dayton, M T; Hebert, J C; Jamieson, C; Neumayer, L A; Sharp, K W; Spence, R K

    1999-12-01

    Faculty members' educational endeavors have generally not received adequate recognition. The Association for Surgical Education in 1993 established a task force to determine the magnitude of this problem and to create a model to address the challenges and opportunities identified. To obtain baseline information, the task force reviewed information from national sources and the literature on recognizing and rewarding faculty members for educational accomplishments. The group also developed and mailed to surgery departments at all U.S. and Canadian medical schools a questionnaire asking about the educational endeavors of the surgery faculty and their recognition for such activities. The response rate after two mailings was only 56%, but the responses reaffirmed the inadequacy of systems for rewarding and recognizing surgeon-teachers and surgeon-educators, and confirmed that the distinction between the roles of teacher and educator was rarely made. The task force created a four-tier hierarchical model based on the designations teacher, master teacher, educator, and master educator as a framework to offer appropriate recognition and rewards to the faculty, and endorsed a broad definition of educational scholarship. Criteria for various levels of achievement, ways to demonstrate and document educational contributions, appropriate support and recognition, and suggested faculty ranks were defined for these levels. The task force recommended that each surgery department have within its faculty ranks a cadre of trained teachers, a few master teachers, and at least one educator. Departments with a major commitment to education should consider supporting a master educator to serve as a resource not only for the department but also for the department's medical school and other medical schools. Although this model was created for surgery departments, it is generalizable to other disciplines. PMID:10619002

  18. Generalized Similarity for Accretion/Decretion Disks

    NASA Astrophysics Data System (ADS)

    Rafikov, Roman R.

    2016-10-01

    Decretion (or external) disks are gas disks freely expanding to large radii due to their internal stresses. They are expected to naturally arise in tidal disruption events, around Be stars, in mass-losing post-main-sequence binaries, as a result of supernova fallback, etc. Their evolution is theoretically understood in two regimes: when the central object does not exert torque on the disk (a standard assumption for conventional accretion disks) or when no mass inflow (or outflow) occurs at the disk center. However, many astrophysical objects—circumbinary disks, Be stars, neutron stars accreting in a propeller regime, etc.—feature non-zero torque simultaneously with the non-zero accretion (or ejection of mass) at the disk center. We provide a general description for the evolution of such disks (both linear and nonlinear) in the self-similar regime, to which the disk should asymptotically converge with time. We identify a similarity parameter λ, which is uniquely related to the degree, to which the central mass accretion is suppressed by the non-zero central torque. The known decretion disk solutions correspond to the two discrete values of λ, while our new solutions cover a continuum of its physically allowed values, corresponding to either accretion or mass ejection by the central object. A direct relationship between λ and central \\dot{M} and torque is also established. We describe the time evolution of the various disk characteristics for different λ, and show that the observable properties (spectrum and luminosity evolution) of the decretion disks, in general, are different from the standard accretion disks with no central torque.

  19. Self-similarity in the inertial region of wall turbulence

    NASA Astrophysics Data System (ADS)

    Klewicki, J.; Philip, J.; Marusic, I.; Chauhan, K.; Morrill-Winter, C.

    2014-12-01

    The inverse of the von Kármán constant κ is the leading coefficient in the equation describing the logarithmic mean velocity profile in wall bounded turbulent flows. Klewicki [J. Fluid Mech. 718, 596 (2013), 10.1017/jfm.2012.626] connects the asymptotic value of κ with an emerging condition of dynamic self-similarity on an interior inertial domain that contains a geometrically self-similar hierarchy of scaling layers. A number of properties associated with the asymptotic value of κ are revealed. This is accomplished using a framework that retains connection to invariance properties admitted by the mean statement of dynamics. The development leads toward, but terminates short of, analytically determining a value for κ . It is shown that if adjacent layers on the hierarchy (or their adjacent positions) adhere to the same self-similarity that is analytically shown to exist between any given layer and its position, then κ ≡Φ-2=0.381 966 ... , where Φ =(1 +√{5 })/2 is the golden ratio. A number of measures, derived specifically from an analysis of the mean momentum equation, are subsequently used to empirically explore the veracity and implications of κ =Φ-2 . Consistent with the differential transformations underlying an invariant form admitted by the governing mean equation, it is demonstrated that the value of κ arises from two geometric features associated with the inertial turbulent motions responsible for momentum transport. One nominally pertains to the shape of the relevant motions as quantified by their area coverage in any given wall-parallel plane, and the other pertains to the changing size of these motions in the wall-normal direction. In accord with self-similar mean dynamics, these two features remain invariant across the inertial domain. Data from direct numerical simulations and higher Reynolds number experiments are presented and discussed relative to the self-similar geometric structure indicated by the analysis, and in particular the

  20. Exploring perceptually similar cases with multi-dimensional scaling

    NASA Astrophysics Data System (ADS)

    Wang, Juan; Yang, Yongyi; Wernick, Miles N.; Nishikawa, Robert M.

    2014-03-01

    Retrieving a set of known lesions similar to the one being evaluated might be of value for assisting radiologists to distinguish between benign and malignant clustered microcalcifications (MCs) in mammograms. In this work, we investigate how perceptually similar cases with clustered MCs may relate to one another in terms of their underlying characteristics (from disease condition to image features). We first conduct an observer study to collect similarity scores from a group of readers (five radiologists and five non-radiologists) on a set of 2,000 image pairs, which were selected from 222 cases based on their images features. We then explore the potential relationship among the different cases as revealed by their similarity ratings. We apply the multi-dimensional scaling (MDS) technique to embed all the cases in a 2-D plot, in which perceptually similar cases are placed in close vicinity of one another based on their level of similarity. Our results show that cases having different characteristics in their clustered MCs are accordingly placed in different regions in the plot. Moreover, cases of same pathology tend to be clustered together locally, and neighboring cases (which are more similar) tend to be also similar in their clustered MCs (e.g., cluster size and shape). These results indicate that subjective similarity ratings from the readers are well correlated with the image features of the underlying MCs of the cases, and that perceptually similar cases could be of diagnostic value for discriminating between malignant and benign cases.

  1. The Influence of Contour on Similarity Perception of Star Glyphs.

    PubMed

    Fuchs, Johannes; Isenberg, Petra; Bezerianos, Anastasia; Fischer, Fabian; Bertini, Enrico

    2014-12-01

    We conducted three experiments to investigate the effects of contours on the detection of data similarity with star glyph variations. A star glyph is a small, compact, data graphic that represents a multi-dimensional data point. Star glyphs are often used in small-multiple settings, to represent data points in tables, on maps, or as overlays on other types of data graphics. In these settings, an important task is the visual comparison of the data points encoded in the star glyph, for example to find other similar data points or outliers. We hypothesized that for data comparisons, the overall shape of a star glyph--enhanced through contour lines--would aid the viewer in making accurate similarity judgments. To test this hypothesis, we conducted three experiments. In our first experiment, we explored how the use of contours influenced how visualization experts and trained novices chose glyphs with similar data values. Our results showed that glyphs without contours make the detection of data similarity easier. Given these results, we conducted a second study to understand intuitive notions of similarity. Star glyphs without contours most intuitively supported the detection of data similarity. In a third experiment, we tested the effect of star glyph reference structures (i.e., tickmarks and gridlines) on the detection of similarity. Surprisingly, our results show that adding reference structures does improve the correctness of similarity judgments for star glyphs with contours, but not for the standard star glyph. As a result of these experiments, we conclude that the simple star glyph without contours performs best under several criteria, reinforcing its practice and popularity in the literature. Contours seem to enhance the detection of other types of similarity, e. g., shape similarity and are distracting when data similarity has to be judged. Based on these findings we provide design considerations regarding the use of contours and reference structures on star

  2. The Influence of Contour on Similarity Perception of Star Glyphs.

    PubMed

    Fuchs, Johannes; Isenberg, Petra; Bezerianos, Anastasia; Fischer, Fabian; Bertini, Enrico

    2014-12-01

    We conducted three experiments to investigate the effects of contours on the detection of data similarity with star glyph variations. A star glyph is a small, compact, data graphic that represents a multi-dimensional data point. Star glyphs are often used in small-multiple settings, to represent data points in tables, on maps, or as overlays on other types of data graphics. In these settings, an important task is the visual comparison of the data points encoded in the star glyph, for example to find other similar data points or outliers. We hypothesized that for data comparisons, the overall shape of a star glyph--enhanced through contour lines--would aid the viewer in making accurate similarity judgments. To test this hypothesis, we conducted three experiments. In our first experiment, we explored how the use of contours influenced how visualization experts and trained novices chose glyphs with similar data values. Our results showed that glyphs without contours make the detection of data similarity easier. Given these results, we conducted a second study to understand intuitive notions of similarity. Star glyphs without contours most intuitively supported the detection of data similarity. In a third experiment, we tested the effect of star glyph reference structures (i.e., tickmarks and gridlines) on the detection of similarity. Surprisingly, our results show that adding reference structures does improve the correctness of similarity judgments for star glyphs with contours, but not for the standard star glyph. As a result of these experiments, we conclude that the simple star glyph without contours performs best under several criteria, reinforcing its practice and popularity in the literature. Contours seem to enhance the detection of other types of similarity, e. g., shape similarity and are distracting when data similarity has to be judged. Based on these findings we provide design considerations regarding the use of contours and reference structures on star

  3. Evaluating Whole Chemical Mixtures and Sufficient Similarity

    EPA Science Inventory

    This powerpoint presentation supports apresentation describing dose-response assessment for complex chemical mixtures including deriving reference doses for mixtures evaluating sufficient similarity among chemical mixtures.

  4. Similarity principle and rejection of Gibbs paradox

    NASA Astrophysics Data System (ADS)

    Lin, Shu-Kun

    2000-03-01

    Gibbs Paradox says that entropy of mixing or assembling decreases discotinuously with the increase in the property similarity. After the rejection of the Gibbs paradox statement (see papers cited at website http://www.mdpi.org/lin/), the similarity principle has been developed: If all the other conditions remain constant, the higher the similarity among the components is, the higher value of entropy of the mixing, the assembling or the chemical bond formation process will be, the more spontaneous the mixing, the assembling or the chemical bond formation process will be, and the more stable the mixture, the assemblage or the chemical bond will be. The similarity principle is very useful. If one wants to mix substances, increase the similarity (of relevant properties); if one plans to separate the substances as phases, reduce their similarity! Then, the desirable processes of mixing or separation will happen spontaneously. Normally by changing temperature ( similarity is related to Boltzmann factor) and pressure, one can control the similarity and in turn, direct the process towards the desired direction. Higher temperature and pressure leads to higher similarity. This theory is important in understanding molecular recognition, self-organization, molecular assembling and molecular replication.

  5. Mining patents using molecular similarity search.

    PubMed

    Rhodes, James; Boyer, Stephen; Kreulen, Jeffrey; Chen, Ying; Ordonez, Patricia

    2007-01-01

    Text analytics is becoming an increasingly important tool used in biomedical research. While advances continue to be made in the core algorithms for entity identification and relation extraction, a need for practical applications of these technologies arises. We developed a system that allows users to explore the US Patent corpus using molecular information. The core of our system contains three main technologies: A high performing chemical annotator which identifies chemical terms and converts them to structures, a similarity search engine based on the emerging IUPAC International Chemical Identifier (InChI) standard, and a set of on demand data mining tools. By leveraging this technology we were able to rapidly identify and index 3,623,248 unique chemical structures from 4,375,036 US Patents and Patent Applications. Using this system a user may go to a web page, draw a molecule, search for related Intellectual Property (IP) and analyze the results. Our results prove that this is a far more effective way for identifying IP than traditional keyword based approaches.

  6. 41 CFR 102-75.740 - Does the State agency have any responsibilities in helping to accomplish the transfer of the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... helping to accomplish the transfer of the property? Yes, the State agency is required to bear the costs of any out-of-pocket expenses necessary to accomplish the transfer, such as costs of surveys, fencing,...

  7. Attitude Similarity, Topic Importance, and Psychotherapeutic Attraction

    ERIC Educational Resources Information Center

    Cheney, Thomas

    1975-01-01

    The effect of attitude similarity and topic importance on attraction was studied by exposing 75 prison inmates, incarcerated for public intoxication, to varying attitudes of a psychotherapist. Subjects were more attracted to the therapist after receiving alcohol items regardless of degree of similarity expressed. (Author)

  8. Interleaving Helps Students Distinguish among Similar Concepts

    ERIC Educational Resources Information Center

    Rohrer, Doug

    2012-01-01

    When students encounter a set of concepts (or terms or principles) that are similar in some way, they often confuse one with another. For instance, they might mistake one word for another word with a similar spelling (e.g., allusion instead of illusion) or choose the wrong strategy for a mathematics problem because it resembles a different kind of…

  9. Similar methodological analysis involving the user experience.

    PubMed

    Almeida e Silva, Caio Márcio; Okimoto, Maria Lúcia R L; Tanure, Raffaela Leane Zenni

    2012-01-01

    This article deals with the use of a protocol for analysis of similar methodological analysis related to user experience. For both, were selected articles recounting experiments in the area. They were analyze based on the similar analysis protocol and finally, synthesized and associated.

  10. Perceived Similarity, Proactive Adjustment, and Organizational Socialization

    ERIC Educational Resources Information Center

    Kammeyer-Mueller, John D.; Livingston, Beth A.; Liao, Hui

    2011-01-01

    The present study explores how perceived demographic and attitudinal similarity can influence proactive behavior among organizational newcomers. We propose that newcomers who perceive themselves as similar to their co-workers will be more willing to seek new information or build relationships, which in turn will lead to better long-term…

  11. Documents Similarity Measurement Using Field Association Terms.

    ERIC Educational Resources Information Center

    Atlam, El-Sayed; Fuketa, M.; Morita, K.; Aoe, Jun-ichi

    2003-01-01

    Discussion of text analysis and information retrieval and measurement of document similarity focuses on a new text manipulation system called FA (field association)-Sim that is useful for retrieving information in large heterogeneous texts and for recognizing content similarity in text excerpts. Discusses recall and precision, automatic indexing…

  12. International space station accomplishments update: Scientific discovery, advancing future exploration, and benefits brought home to earth

    NASA Astrophysics Data System (ADS)

    Thumm, Tracy; Robinson, Julie A.; Alleyne, Camille; Hasbrook, Pete; Mayo, Susan; Buckley, Nicole; Johnson-Green, Perry; Karabadzhak, George; Kamigaichi, Shigeki; Umemura, Sayaka; Sorokin, Igor V.; Zell, Martin; Istasse, Eric; Sabbagh, Jean; Pignataro, Salvatore

    2014-10-01

    Throughout the history of the International Space Station (ISS), crews on board have conducted a variety of scientific research and educational activities. Well into the second year of full utilization of the ISS laboratory, the trend of scientific accomplishments and educational opportunities continues to grow. More than 1500 investigations have been conducted on the ISS since the first module launched in 1998, with over 700 scientific publications. The ISS provides a unique environment for research, international collaboration and educational activities that benefit humankind. This paper will provide an up to date summary of key investigations, facilities, publications, and benefits from ISS research that have developed over the past year. Discoveries in human physiology and nutrition have enabled astronauts to return from ISS with little bone loss, even as scientists seek to better understand the new puzzle of “ocular syndrome” affecting the vision of up to half of astronauts. The geneLAB campaign will unify life sciences investigations to seek genomic, proteomic and metabolomics of the effect of microgravity on life as a whole. Combustion scientists identified a new “cold flame” phenomenon that has the potential to improve models of efficient combustion back on Earth. A significant number of instruments in Earth remote sensing and astrophysics are providing new access to data or nearing completion for launch, making ISS a significant platform for understanding of the Earth system and the universe. In addition to multidisciplinary research, the ISS partnership conducts a myriad of student led research investigations and educational activities aimed at increasing student interest in science, technology, engineering and mathematics (STEM). Over the past year, the ISS partnership compiled new statistics of the educational impact of the ISS on students around the world. More than 43 million students, from kindergarten to graduate school, with more than 28

  13. International Space Station Accomplishments Update: Scientific Discovery, Advancing Future Exploration, and Benefits Brought Home to Earth

    NASA Technical Reports Server (NTRS)

    Thumm, Tracy; Robinson, Julie A.; Alleyne, Camille; Hasbrook, Pete; Mayo, Susan; Johnson-Green, Perry; Buckley, Nicole; Karabadzhak, George; Kamigaichi, Shigeki; Umemura, Sayaka; Sorokin, Igor V.; Zell, Martin; Istasse, Eric; Sabbagh, Jean; Pignataro, Salvatore

    2013-01-01

    Throughout the history of the International Space Station (ISS), crews on board have conducted a variety of scientific research and educational activities. Well into the second year of full utilization of the ISS laboratory, the trend of scientific accomplishments and educational opportunities continues to grow. More than 1500 investigations have been conducted on the ISS since the first module launched in 1998, with over 700 scientific publications. The ISS provides a unique environment for research, international collaboration and educational activities that benefit humankind. This paper will provide an up to date summary of key investigations, facilities, publications, and benefits from ISS research that have developed over the past year. Discoveries in human physiology and nutrition have enabled astronauts to return from ISS with little bone loss, even as scientists seek to better understand the new puzzle of "ocular syndrome" affecting the vision of up to half of astronauts. The geneLAB campaign will unify life sciences investigations to seek genomic, proteomic, and metabolomics of the effect of microgravity on life as a whole. Combustion scientists identified a new "cold flame" phenomenon that has the potential to improve models of efficient combustion back on Earth. A significant number of instruments in Earth remote sensing and astrophysics are providing new access to data or nearing completion for launch, making ISS a significant platform for understanding of the Earth system and the universe. In addition to multidisciplinary research, the ISS partnership conducts a myriad of student led research investigations and educational activities aimed at increasing student interest in science, technology, engineering and mathematics (STEM). Over the past year, the ISS partnership compiled new statistics of the educational impact of the ISS on students around the world. More than 43 million students, from kindergarten to graduate school, with more than 28 million

  14. Similarity and Reciprocity in the Friendships of Elementary School Children.

    ERIC Educational Resources Information Center

    Clark, M. L.; Drewry, Debra L.

    1985-01-01

    Investigated the effect of similarity and reciprocity on dyadic friendship choices in third- and sixth-grade students. Reciprocal (mutual) friendships were more similar in proximity, popularity, and self-concept than those in nonreciprocal (nonmutual) dyads. Results are discussed in relation to the interpersonal attraction theories. (Author/DST)

  15. Sample selection in foreign similarity regions for multicrop experiments

    NASA Technical Reports Server (NTRS)

    Malin, J. T. (Principal Investigator)

    1981-01-01

    The selection of sample segments in the U.S. foreign similarity regions for development of proportion estimation procedures and error modeling for Argentina, Australia, Brazil, and USSR in AgRISTARS is described. Each sample was chosen to be similar in crop mix to the corresponding indicator region sample. Data sets, methods of selection, and resulting samples are discussed.

  16. Observational Learning and the Effects of Model-Observer Similarity.

    ERIC Educational Resources Information Center

    Braaksma, Martine A. H.; Rijlaarsdam, Gert; van den Bergh, Huub

    2002-01-01

    This study examined the effects of similarity in competence between model and observer on the effectiveness of observational learning in argumentative writing. Results are consistent with the similarity hypothesis: weak learners learn more from focusing their observations on weak models, whereas better learners learn more from focusing on good…

  17. Investigation of vapor cloud formation and dynamic behavior during plasma strikes similar to fusion disruptions

    NASA Astrophysics Data System (ADS)

    Gray, Travis; Surla, Vijay; Ruzic, David

    2009-11-01

    The Divertor Erosion and Vapor shielding eXperiment (DEVeX) at the University of Illinois at Urbana-Champaign is designed to produce plasmas with densities on the order of 10^21 m-3 with a electron temperature greater than 100 eV. This is accomplished with the rapid discharge of a 64 kJ capacitor bank through a conical shaped θ-pinch coil. This study utilizes a thin lithium film as the target. The expanding lithium vapor cloud is measured with an axial array of calibrated photodiodes. Vapor temperature is deduced from a collisional-radiative model of lithium interactions with energetic ions and electrons from the bombarding plasma and found to be 1-2 eV. The vapor cold is also found to cool adiabatically as it expands into the vacuum chamber after the plasma strike. Furthermore, the thin lithium film reduces the incident energy to the target (compared to a bare, non-lithium coated target) by up to 81%. The result is a significantly cooler target temperature under similar plasma bombardment.

  18. Similarity-based global optimization of buildings in urban scene

    NASA Astrophysics Data System (ADS)

    Zhu, Quansheng; Zhang, Jing; Jiang, Wanshou

    2013-10-01

    In this paper, an approach for the similarity-based global optimization of buildings in urban scene is presented. In the past, most researches concentrated on single building reconstruction, making it difficult to reconstruct reliable models from noisy or incomplete point clouds. To obtain a better result, a new trend is to utilize the similarity among the buildings. Therefore, a new similarity detection and global optimization strategy is adopted to modify local-fitting geometric errors. Firstly, the hierarchical structure that consists of geometric, topological and semantic features is constructed to represent complex roof models. Secondly, similar roof models can be detected by combining primitive structure and connection similarities. At last, the global optimization strategy is applied to preserve the consistency and precision of similar roof structures. Moreover, non-local consolidation is adapted to detect small roof parts. The experiments reveal that the proposed method can obtain convincing roof models and promote the reconstruction quality of 3D buildings in urban scene.

  19. Perceptual similarity of regional dialects of American English

    PubMed Central

    Clopper, Cynthia G.; Levi, Susannah V.; Pisoni, David B.

    2012-01-01

    Previous research on the perception of dialect variation has measured the perceptual similarity of talkers based on regional dialect using only indirect methods. In the present study, a paired comparison similarity ratings task was used to obtain direct measures of perceptual similarity. Naive listeners were asked to make explicit judgments about the similarity of a set of talkers based on regional dialect. The talkers represented four regional varieties of American English and both genders. Results revealed an additive effect of gender and dialect on mean similarity ratings and two primary dimensions of perceptual dialect similarity: geography (northern versus southern varieties) and dialect markedness (many versus few characteristic properties). The present findings are consistent with earlier research on the perception of dialect variation, as well as recent speech perception studies which demonstrate the integral role of talker gender in speech perception. PMID:16454310

  20. Similarity metrics for ligands reflecting the similarity of the target proteins.

    PubMed

    Schuffenhauer, Ansgar; Floersheim, Philipp; Acklin, Pierre; Jacoby, Edgar

    2003-01-01

    target as the reference set. However, the application of the Similog keys is more effective in comparison with the other investigated methods in the identification of ligands binding to any target belonging to the same family as the reference target. We attribute this superiority to the fact that the Similog keys provide a generalization of the chemical elements and that the keys are counted instead of merely noting their presence or absence in a binary form. The second most effective molecular representation are the occurrence counts of the public ISIS key fragments, which like the Similog method, incorporates key counting as well as a generalization of the chemical elements. The results obtained suggest that ligands for a new target can be identified by the following three-step procedure: 1. Select at least one target with known ligands which is homologous to the new target. 2. Combine the known ligands of the selected target(s) to a reference set. 3. Search candidate ligands for the new targets by their similarity to the reference set using the Similog method. This clearly enlarges the scope of similarity searching from the classical application for a single target to the identification of candidate ligands for whole target families and is expected to be of key utility for further systematic chemogenomics exploration of previously well explored target families.

  1. Phonological similarity and orthographic similarity affect probed serial recall of Chinese characters.

    PubMed

    Lin, Yi-Chen; Chen, Hsiang-Yu; Lai, Yvonne C; Wu, Denise H

    2015-04-01

    The previous literature on working memory (WM) has indicated that verbal materials are dominantly retained in phonological representations, whereas other linguistic information (e.g., orthography, semantics) only contributes to verbal WM minimally, if not negligibly. Although accumulating evidence has suggested that multiple linguistic components jointly support verbal WM, the visual/orthographic contribution has rarely been addressed in alphabetic languages, possibly due to the difficulty of dissociating the effects of word forms from the effects of their pronunciations in relatively shallow orthography. In the present study, we examined whether the orthographic representations of Chinese characters support the retention of verbal materials in this language of deep orthography. In Experiments 1a and 2, we independently manipulated the phonological and orthographic similarity of horizontal and vertical characters, respectively, and found that participants' accuracy of probed serial recall was reduced by both similar pronunciations and shared phonetic radicals in the to-be-remembered stimuli. Moreover, Experiment 1b showed that only the effect of phonological, but not that of orthographic, similarity was affected by concurrent articulatory suppression. Taken together, the present results indicate the indispensable contribution of orthographic representations to verbal WM of Chinese characters, and suggest that the linguistic characteristics of a specific language not only determine long-term linguistic-processing mechanisms, but also delineate the organization of verbal WM for that language. PMID:25537954

  2. Transsaccadic identification of highly similar artificial shapes.

    PubMed

    Demeyer, Maarten; De Graef, Peter; Wagemans, Johan; Verfaillie, Karl

    2009-04-30

    Multiple times per second, the visual system succeeds in making a seamless transition between presaccadic and postsaccadic perception. The nature of the transsaccadic representation needed to support this was commonly thought to be sparse and abstract. However, recent studies have suggested that detailed visual information is transferred across saccades as well. Here, we seek to confirm that preview effects of visual detail on postsaccadic perception do indeed occur. We presented subjects with highly similar artificial shapes, preceded by a congruent, an incongruent, or no preview. Postsaccadic recognition performance was measured, while the contrast of presaccadic and postsaccadic stimuli was manipulated independently. The results show that congruent previews provided a benefit to the recognition performance of postsaccadic stimuli, compared to no-preview conditions. Incongruent previews induced a recognition accuracy cost, combined with a recognition speed benefit. A second experiment showed that these effects can disappear when stimulus presentation is interrupted with a postsaccadic visual mask. We conclude that visual detail contained in transsaccadic memory can affect the postsaccadic percept. Furthermore, we find that the transsaccadic representation supporting this process is contrast-independent, but that postsaccadic contrast, through its effect on the reliability of information, can affect the degree to which it is employed.

  3. Exploring similarities among many species distributions

    USGS Publications Warehouse

    Simmerman, Scott; Wang, Jingyuan; Osborne, James; Shook, Kimberly; Huang, Jian; Godsoe, William; Simons, Theodore R.

    2012-01-01

    Collecting species presence data and then building models to predict species distribution has been long practiced in the field of ecology for the purpose of improving our understanding of species relationships with each other and with the environment. Due to limitations of computing power as well as limited means of using modeling software on HPC facilities, past species distribution studies have been unable to fully explore diverse data sets. We build a system that can, for the first time to our knowledge, leverage HPC to support effective exploration of species similarities in distribution as well as their dependencies on common environmental conditions. Our system can also compute and reveal uncertainties in the modeling results enabling domain experts to make informed judgments about the data. Our work was motivated by and centered around data collection efforts within the Great Smoky Mountains National Park that date back to the 1940s. Our findings present new research opportunities in ecology and produce actionable field-work items for biodiversity management personnel to include in their planning of daily management activities.

  4. Measure of Node Similarity in Multilayer Networks

    PubMed Central

    Mollgaard, Anders; Zettler, Ingo; Dammeyer, Jesper; Jensen, Mogens H.; Lehmann, Sune; Mathiesen, Joachim

    2016-01-01

    The weight of links in a network is often related to the similarity of the nodes. Here, we introduce a simple tunable measure for analysing the similarity of nodes across different link weights. In particular, we use the measure to analyze homophily in a group of 659 freshman students at a large university. Our analysis is based on data obtained using smartphones equipped with custom data collection software, complemented by questionnaire-based data. The network of social contacts is represented as a weighted multilayer network constructed from different channels of telecommunication as well as data on face-to-face contacts. We find that even strongly connected individuals are not more similar with respect to basic personality traits than randomly chosen pairs of individuals. In contrast, several socio-demographics variables have a significant degree of similarity. We further observe that similarity might be present in one layer of the multilayer network and simultaneously be absent in the other layers. For a variable such as gender, our measure reveals a transition from similarity between nodes connected with links of relatively low weight to dis-similarity for the nodes connected by the strongest links. We finally analyze the overlap between layers in the network for different levels of acquaintanceships. PMID:27300084

  5. Measure of Node Similarity in Multilayer Networks.

    PubMed

    Mollgaard, Anders; Zettler, Ingo; Dammeyer, Jesper; Jensen, Mogens H; Lehmann, Sune; Mathiesen, Joachim

    2016-01-01

    The weight of links in a network is often related to the similarity of the nodes. Here, we introduce a simple tunable measure for analysing the similarity of nodes across different link weights. In particular, we use the measure to analyze homophily in a group of 659 freshman students at a large university. Our analysis is based on data obtained using smartphones equipped with custom data collection software, complemented by questionnaire-based data. The network of social contacts is represented as a weighted multilayer network constructed from different channels of telecommunication as well as data on face-to-face contacts. We find that even strongly connected individuals are not more similar with respect to basic personality traits than randomly chosen pairs of individuals. In contrast, several socio-demographics variables have a significant degree of similarity. We further observe that similarity might be present in one layer of the multilayer network and simultaneously be absent in the other layers. For a variable such as gender, our measure reveals a transition from similarity between nodes connected with links of relatively low weight to dis-similarity for the nodes connected by the strongest links. We finally analyze the overlap between layers in the network for different levels of acquaintanceships. PMID:27300084

  6. Summary of activities and accomplishments. Volume IV. A proposal to develop a method for the detection of HE employing chemiluminescence reactions. Final progress report

    SciTech Connect

    Neary, M.P.

    1981-01-01

    This is the final and fourth quarter report for the study of high explosive (HE) detection by coupling the chemistry of HE with that of luminol reaction, a well-known chemiluminescence (CL) reaction. Our accomplishments include: success in coupling HE and CL chemistry reliably; the capability to use a micellized solvent to concentrate HE; and the basis for design instrumentation that may exhibit better sensitivity and lower levels of detection than that exhibited by the laboratory apparatus used for this study. On the basis of these results we are prepared to recommend further study.

  7. Fingerprint comparison. I: Similarity of fingerprints.

    PubMed

    Lin, C H; Liu, J H; Osterburg, J W; Nicol, J D

    1982-04-01

    Fingerprints from 61 pairs of male monozygotic twins (MZ), 47 pairs of female MZ, 40 pairs of same-sex male dizygotic twins (DZ), 44 pairs of same-sex female DZ, 4 pairs of opposite-sex DZ, and 28 brothers and 31 sisters of those twins are used for the study of fingerprint similarities. Similarities of fingerprint pattern, ridge count, and minutiae are evaluated for two population groups genetically related to each other in different degrees. It is concluded that fingerprint similarities, including pattern, ridge count, and possibly minutiae, between MZ individuals are significantly higher than those between other population groups, including DZ twins.

  8. Humans and Insects Decide in Similar Ways

    PubMed Central

    Louâpre, Philippe; van Alphen, Jacques J. M.; Pierre, Jean-Sébastien

    2010-01-01

    Behavioral ecologists assume that animals use a motivational mechanism for decisions such as action selection and time allocation, allowing the maximization of their fitness. They consider both the proximate and ultimate causes of behavior in order to understand this type of decision-making in animals. Experimental psychologists and neuroeconomists also study how agents make decisions but they consider the proximate causes of the behavior. In the case of patch-leaving, motivation-based decision-making remains simple speculation. In contrast to other animals, human beings can assess and evaluate their own motivation by an introspection process. It is then possible to study the declared motivation of humans during decision-making and discuss the mechanism used as well as its evolutionary significance. In this study, we combine both the proximate and ultimate causes of behavior for a better understanding of the human decision-making process. We show for the first time ever that human subjects use a motivational mechanism similar to small insects such as parasitoids [1] and bumblebees [2] to decide when to leave a patch. This result is relevant for behavioral ecologists as it supports the biological realism of this mechanism. Humans seem to use a motivational mechanism of decision making known to be adaptive to a heterogeneously distributed resource. As hypothesized by Hutchinson et al. [3] and Wilke and Todd [4], our results are consistent with the evolutionary shaping of decision making because hominoids were hunters and gatherers on food patches for more than two million years. We discuss the plausibility of a neural basis for the motivation mechanism highlighted here, bridging the gap between behavioral ecology and neuroeconomy. Thus, both the motivational mechanism observed here and the neuroeconomy findings are most likely adaptations that were selected for during ancestral times. PMID:21170378

  9. Expanding the boundaries of local similarity analysis

    PubMed Central

    2013-01-01

    Background Pairwise comparison of time series data for both local and time-lagged relationships is a computationally challenging problem relevant to many fields of inquiry. The Local Similarity Analysis (LSA) statistic identifies the existence of local and lagged relationships, but determining significance through a p-value has been algorithmically cumbersome due to an intensive permutation test, shuffling rows and columns and repeatedly calculating the statistic. Furthermore, this p-value is calculated with the assumption of normality -- a statistical luxury dissociated from most real world datasets. Results To improve the performance of LSA on big datasets, an asymptotic upper bound on the p-value calculation was derived without the assumption of normality. This change in the bound calculation markedly improved computational speed from O(pm2n) to O(m2n), where p is the number of permutations in a permutation test, m is the number of time series, and n is the length of each time series. The bounding process is implemented as a computationally efficient software package, FASTLSA, written in C and optimized for threading on multi-core computers, improving its practical computation time. We computationally compare our approach to previous implementations of LSA, demonstrate broad applicability by analyzing time series data from public health, microbial ecology, and social media, and visualize resulting networks using the Cytoscape software. Conclusions The FASTLSA software package expands the boundaries of LSA allowing analysis on datasets with millions of co-varying time series. Mapping metadata onto force-directed graphs derived from FASTLSA allows investigators to view correlated cliques and explore previously unrecognized network relationships. The software is freely available for download at: http://www.cmde.science.ubc.ca/hallam/fastLSA/. PMID:23368516

  10. Advancing computational toxicology in a regulatory setting: A selected review of the accomplishments of Gilman D. Veith (1944-2013)

    EPA Science Inventory

    Gilman Veith joined the US Environmental Protection Agency (EPA), and its Office of Research and Development, in 1972. Spanning 30 years of public service with EPA through 2003, Gil’s accomplishments in leading multidisciplinary research teams to successfully address a broad spe...

  11. Florida's Adult Education Programs: Challenges and Accomplishments. A Report for Fiscal Year 1991 [and] Fiscal Year 1992.

    ERIC Educational Resources Information Center

    Gardner, Daniel L.

    These two reports outline accomplishments and challenges faced by Florida's AE program in FY91 and FY92 in the following areas: adult literacy, social participation, career development, special needs of the AE program's diverse identified target groups, high school completion, General Educational Development, workplace literacy, networking,…

  12. 41 CFR 102-74.255 - How must occupant evacuation or relocation be accomplished when there is immediate danger to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... evacuation or relocation be accomplished when there is immediate danger to persons or property, such as fire... danger to persons or property, such as fire, explosion or the discovery of an explosive device (not... immediate danger to persons or property, such as fire, explosion or the discovery of an explosive...

  13. When Social Support Is Uncomfortable. The Communicative Accomplishment of Support as a Cultural Term in a Youth Intervention Program.

    ERIC Educational Resources Information Center

    Sass, James S.; Mattson, Marifran

    1999-01-01

    Expands understanding of social support by addressing the communicative use of support in a community program for troubled teens. Presents the ways in which the organization accomplishes and constructs support. Identifies and explores two novel aspects of supportive communication: supportive communication that may be perceived as uncomfortable and…

  14. Investing in the Improvement of Mathematics and Science Education in Rural Appalachia: Ten Years of ARSI and Its Accomplishments

    ERIC Educational Resources Information Center

    Inverness Research Associates, 2006

    2006-01-01

    This report provides the reader with a summary of the rationale, design strategies, and major accomplishments of the Appalachian Rural Systemic Initiative (ARSI). Drawing upon both the data collected directly in Appalachia by Inverness Research Associates, as well as knowledge gained by working with many other rural initiatives, this summary…

  15. Identifying Effective Schools: A Case Study Involving Black Racially Isolated Minority Schools and Instructional Accomplishment Information Systems.

    ERIC Educational Resources Information Center

    Behr, George; Bachelor, Barry

    This study outlines and demonstrates a methodology for identifying effective schools using a random sample of student data generated by the operation of a school district's Instructional Accomplishment Information (IAI) system. (IAI systems are designed to provide school districts with information for reviewing and planning their instructional…

  16. Jefferson College Professional Development System Booklet: Promotion System for Rewarding Outstanding Faculty Accomplishment in Diverse Professional Areas. Revised.

    ERIC Educational Resources Information Center

    Jefferson Coll., Hillsboro, MO.

    This booklet explains Jefferson College's Professional Development System (PDS), a promotion system for rewarding outstanding faculty accomplishment, and explains the calculations used in evaluating faculty performance. After explaining that the PDS was created so that the rewarding of faculty would not be arbitrary but in proportion to their…

  17. TERRA FIRMA. Threshold of Educational Reform Restructuring Agriculture for Inner City Related Motivation and Accomplishments. Final Report.

    ERIC Educational Resources Information Center

    Fulmer, John L.

    The report describes the first year (1974-75) activities and accomplishments of a project to provide a cooperative-based vocational agriculture program for secondary students in Anniston, Alabama. The overall objectives were to provide instruction in livestock production and horticulture, leadership training, participatory experience on a real…

  18. "He Talks to You, Not at You": Attending to Learners' Perspectives to Enhance Understanding of Accomplished Teaching

    ERIC Educational Resources Information Center

    Kriewaldt, Jeana

    2009-01-01

    The voices of students can make a significant contribution to understanding what constitutes accomplished teaching (Flutter, 2007). Young people give cogent and significant views about their learning, providing important insights for improving teaching (Rudduck, McIntyre, & ESRC Teaching and Learning Programme., 2007). Using a qualitative…

  19. Orthographic similarity: the case of "reversed anagrams".

    PubMed

    Morris, Alison L; Still, Mary L

    2012-07-01

    How orthographically similar are words such as paws and swap, flow and wolf, or live and evil? According to the letter position coding schemes used in models of visual word recognition, these reversed anagrams are considered to be less similar than words that share letters in the same absolute or relative positions (such as home and hose or plan and lane). Therefore, reversed anagrams should not produce the standard orthographic similarity effects found using substitution neighbors (e.g., home, hose). Simulations using the spatial coding model (Davis, Psychological Review 117, 713-758, 2010), for example, predict an inhibitory masked-priming effect for substitution neighbor word pairs but a null effect for reversed anagrams. Nevertheless, we obtained significant inhibitory priming using both stimulus types (Experiment 1). We also demonstrated that robust repetition blindness can be obtained for reversed anagrams (Experiment 2). Reversed anagrams therefore provide a new test for models of visual word recognition and orthographic similarity.

  20. Interpersonal Congruency, Attitude Similarity, and Interpersonal Attraction

    ERIC Educational Resources Information Center

    Touhey, John C.

    1975-01-01

    As no experimental study has examined the effects of congruency on attraction, the present investigation orthogonally varied attitude similarity and interpersonal congruency in order to compare the two independent variables as determinants of interpersonal attraction. (Author/RK)

  1. HYPOTHESIS TESTING WITH THE SIMILARITY INDEX

    EPA Science Inventory

    Mulltilocus DNA fingerprinting methods have been used extensively to address genetic issues in wildlife populations. Hypotheses concerning population subdivision and differing levels of diversity can be addressed through the use of the similarity index (S), a band-sharing coeffic...

  2. Evaluating Similarity Measures for Brain Image Registration

    PubMed Central

    Razlighi, Q. R.; Kehtarnavaz, N.; Yousefi, S.

    2013-01-01

    Evaluation of similarity measures for image registration is a challenging problem due to its complex interaction with the underlying optimization, regularization, image type and modality. We propose a single performance metric, named robustness, as part of a new evaluation method which quantifies the effectiveness of similarity measures for brain image registration while eliminating the effects of the other parts of the registration process. We show empirically that similarity measures with higher robustness are more effective in registering degraded images and are also more successful in performing intermodal image registration. Further, we introduce a new similarity measure, called normalized spatial mutual information, for 3D brain image registration whose robustness is shown to be much higher than the existing ones. Consequently, it tolerates greater image degradation and provides more consistent outcomes for intermodal brain image registration. PMID:24039378

  3. Bilateral Trade Flows and Income Distribution Similarity.

    PubMed

    Martínez-Zarzoso, Inmaculada; Vollmer, Sebastian

    2016-01-01

    Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model of trade. A theoretically justified gravity model is estimated for disaggregated trade data (Dollar volume is used as dependent variable) using a sample of 104 exporters and 108 importers for 1980-2003 to achieve two main goals. We define and calculate new measures of income distribution similarity and empirically confirm that greater similarity of income distribution between countries implies more trade. Using distribution-based measures as a proxy for demand similarities in gravity models, we find consistent and robust support for the hypothesis that countries with more similar income-distributions trade more with each other. The hypothesis is also confirmed at disaggregated level for differentiated product categories.

  4. Bilateral Trade Flows and Income Distribution Similarity

    PubMed Central

    2016-01-01

    Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model of trade. A theoretically justified gravity model is estimated for disaggregated trade data (Dollar volume is used as dependent variable) using a sample of 104 exporters and 108 importers for 1980–2003 to achieve two main goals. We define and calculate new measures of income distribution similarity and empirically confirm that greater similarity of income distribution between countries implies more trade. Using distribution-based measures as a proxy for demand similarities in gravity models, we find consistent and robust support for the hypothesis that countries with more similar income-distributions trade more with each other. The hypothesis is also confirmed at disaggregated level for differentiated product categories. PMID:27137462

  5. Similarity Theory of Withdrawn Water Temperature Experiment

    PubMed Central

    2015-01-01

    Selective withdrawal from a thermal stratified reservoir has been widely utilized in managing reservoir water withdrawal. Besides theoretical analysis and numerical simulation, model test was also necessary in studying the temperature of withdrawn water. However, information on the similarity theory of the withdrawn water temperature model remains lacking. Considering flow features of selective withdrawal, the similarity theory of the withdrawn water temperature model was analyzed theoretically based on the modification of governing equations, the Boussinesq approximation, and some simplifications. The similarity conditions between the model and the prototype were suggested. The conversion of withdrawn water temperature between the model and the prototype was proposed. Meanwhile, the fundamental theory of temperature distribution conversion was firstly proposed, which could significantly improve the experiment efficiency when the basic temperature of the model was different from the prototype. Based on the similarity theory, an experiment was performed on the withdrawn water temperature which was verified by numerical method. PMID:26065020

  6. Bilateral Trade Flows and Income Distribution Similarity.

    PubMed

    Martínez-Zarzoso, Inmaculada; Vollmer, Sebastian

    2016-01-01

    Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model of trade. A theoretically justified gravity model is estimated for disaggregated trade data (Dollar volume is used as dependent variable) using a sample of 104 exporters and 108 importers for 1980-2003 to achieve two main goals. We define and calculate new measures of income distribution similarity and empirically confirm that greater similarity of income distribution between countries implies more trade. Using distribution-based measures as a proxy for demand similarities in gravity models, we find consistent and robust support for the hypothesis that countries with more similar income-distributions trade more with each other. The hypothesis is also confirmed at disaggregated level for differentiated product categories. PMID:27137462

  7. Self-similarity in Laplacian growth

    SciTech Connect

    Mineev-weinstein, Mark; Zabrodin, Anton; Abanov, Artem

    2008-01-01

    We consider Laplacian Growth of self-similar domains in different geometries. Self-similarity determines the analytic structure of the Schwarz function of the moving boundary. The knowledge of this analytic structure allows us to derive the integral equation for the conformal map. It is shown that solutions to the integral equation obey also a second-order differential equation which is the 1D Schroedinger equation with the sinh{sup -2}-potential. The solutions, which are expressed through the Gauss hypergeometric function, characterize the geometry of self-similar patterns in a wedge. We also find the potential for the Coulomb gas representation of the self-similar Laplacian growth in a wedge and calculate the corresponding free energy.

  8. 3-D heterogeneous field data versus 2-D simulations. How can it be accomplished in a sedimentary porous formation?

    NASA Astrophysics Data System (ADS)

    Darvini, G.; Salandin, P.

    2009-12-01

    To analyze the impact of the hydraulic conductivity K spatial variability in a real field case (as an example to delimitate a well catchment), numerical simulations can be reasonably developed in a two-dimensional vertical average context. Nevertheless the plume evolution is a consequence of a more complex three-dimensional heterogeneous structure whose vertical variability dominates the dispersion phenomena at local scale. In larger domains, the effect of the vertical heterogeneity combines itself with that one due to the horizontal variability of K, and only when the plume has travelled a large number of (horizontal) integral scales, its evolution can be analyzed in a regional context, under the hypothesis that the transmissivity spatial distribution prevails. Until this limit is reached, the vertical and horizontal variability of K are combined to give a fully 3-D dispersion process. In all these situations, to successfully accomplish the 3-D heterogeneous structure of the aquifer in 2-D simulations, more than the planimetric depth-averaged variability of K must be accounted for. To define the uncertainty related to the use of different planimetric schematizations of the real hydraulic conductivity spatial distribution, we present here the results of some numerical experiments that compare the 3-D plume evolution with 2-D simulations developed by tacking into account different hydraulic conductivity distribution schematization, by considering a hierarchical architecture of media also. This description of a sedimentary formation combined with the finite size of the plume requires theoretical and numerical tools able to take into account the flow field inhomogeneity and the ergodicity lack that characterize the transport phenomena. Following this way it will be possible to quantify / reduce the uncertainty related to a 2-D schematization in a large number of real cases where the domain spans between the local and the regional scale and whose dimension may lead to

  9. Interpersonal attraction and personality: what is attractive--self similarity, ideal similarity, complementarity or attachment security?

    PubMed

    Klohnen, Eva C; Luo, Shanhong

    2003-10-01

    Little is known about whether personality characteristics influence initial attraction. Because adult attachment differences influence a broad range of relationship processes, the authors examined their role in 3 experimental attraction studies. The authors tested four major attraction hypotheses--self similarity, ideal-self similarity, complementarity, and attachment security--and examined both actual and perceptual factors. Replicated analyses across samples, designs, and manipulations showed that actual security and self similarity predicted attraction. With regard to perceptual factors, ideal similarity, self similarity, and security all were significant predictors. Whereas perceptual ideal and self similarity had incremental predictive power, perceptual security's effects were subsumed by perceptual ideal similarity. Perceptual self similarity fully mediated actual attachment similarity effects, whereas ideal similarity was only a partial mediator. PMID:14561124

  10. Privacy-preserving matching of similar patients.

    PubMed

    Vatsalan, Dinusha; Christen, Peter

    2016-02-01

    The identification of similar entities represented by records in different databases has drawn considerable attention in many application areas, including in the health domain. One important type of entity matching application that is vital for quality healthcare analytics is the identification of similar patients, known as similar patient matching. A key component of identifying similar records is the calculation of similarity of the values in attributes (fields) between these records. Due to increasing privacy and confidentiality concerns, using the actual attribute values of patient records to identify similar records across different organizations is becoming non-trivial because the attributes in such records often contain highly sensitive information such as personal and medical details of patients. Therefore, the matching needs to be based on masked (encoded) values while being effective and efficient to allow matching of large databases. Bloom filter encoding has widely been used as an efficient masking technique for privacy-preserving matching of string and categorical values. However, no work on Bloom filter-based masking of numerical data, such as integer (e.g. age), floating point (e.g. body mass index), and modulus (numbers wrap around upon reaching a certain value, e.g. date and time), which are commonly required in the health domain, has been presented in the literature. We propose a framework with novel methods for masking numerical data using Bloom filters, thereby facilitating the calculation of similarities between records. We conduct an empirical study on publicly available real-world datasets which shows that our framework provides efficient masking and achieves similar matching accuracy compared to the matching of actual unencoded patient records.

  11. Privacy-preserving matching of similar patients.

    PubMed

    Vatsalan, Dinusha; Christen, Peter

    2016-02-01

    The identification of similar entities represented by records in different databases has drawn considerable attention in many application areas, including in the health domain. One important type of entity matching application that is vital for quality healthcare analytics is the identification of similar patients, known as similar patient matching. A key component of identifying similar records is the calculation of similarity of the values in attributes (fields) between these records. Due to increasing privacy and confidentiality concerns, using the actual attribute values of patient records to identify similar records across different organizations is becoming non-trivial because the attributes in such records often contain highly sensitive information such as personal and medical details of patients. Therefore, the matching needs to be based on masked (encoded) values while being effective and efficient to allow matching of large databases. Bloom filter encoding has widely been used as an efficient masking technique for privacy-preserving matching of string and categorical values. However, no work on Bloom filter-based masking of numerical data, such as integer (e.g. age), floating point (e.g. body mass index), and modulus (numbers wrap around upon reaching a certain value, e.g. date and time), which are commonly required in the health domain, has been presented in the literature. We propose a framework with novel methods for masking numerical data using Bloom filters, thereby facilitating the calculation of similarities between records. We conduct an empirical study on publicly available real-world datasets which shows that our framework provides efficient masking and achieves similar matching accuracy compared to the matching of actual unencoded patient records. PMID:26707453

  12. Similarity to the self influences cortical recruitment during impression formation.

    PubMed

    Leshikar, Eric D; Cassidy, Brittany S; Gutchess, Angela H

    2016-04-01

    Prior work has shown that whether or not someone is similar to the self influences person memory--a type of self-reference effect for others. In this study, we were interested in understanding the neural regions supporting the generation of impressions and subsequent memory for targets who vary in similarity to the self. Participants underwent fMRI scanning while forming positive or negative impressions of face-behavior pairs. We tested participants' memory for their generated impressions and then back-sorted the impression trials (encoding) into different levels of self-similarity (high, medium, low) using a self-similarity posttest that came after recognition. Extending prior behavioral work, our data confirmed our hypothesis that memory would be highest for self-similar others and lowest for self-dissimilar others. Dorsal anterior cingulate cortex (dACC) activity increased with self-similarity (high > medium > low) to targets, regardless of later memory for them. An analysis of regions supporting impression memory revealed a double dissociation within medial temporal lobe regions: for similar others, amygdala recruitment supported memory, whereas for dissimilar others, hippocampal activation supported memory. These results suggest that self-similarity influences evaluation and memory for targets but also affects the underlying neural resources engaged when thinking about others who vary in self-similarity. PMID:26558615

  13. Similarity to the self influences cortical recruitment during impression formation.

    PubMed

    Leshikar, Eric D; Cassidy, Brittany S; Gutchess, Angela H

    2016-04-01

    Prior work has shown that whether or not someone is similar to the self influences person memory--a type of self-reference effect for others. In this study, we were interested in understanding the neural regions supporting the generation of impressions and subsequent memory for targets who vary in similarity to the self. Participants underwent fMRI scanning while forming positive or negative impressions of face-behavior pairs. We tested participants' memory for their generated impressions and then back-sorted the impression trials (encoding) into different levels of self-similarity (high, medium, low) using a self-similarity posttest that came after recognition. Extending prior behavioral work, our data confirmed our hypothesis that memory would be highest for self-similar others and lowest for self-dissimilar others. Dorsal anterior cingulate cortex (dACC) activity increased with self-similarity (high > medium > low) to targets, regardless of later memory for them. An analysis of regions supporting impression memory revealed a double dissociation within medial temporal lobe regions: for similar others, amygdala recruitment supported memory, whereas for dissimilar others, hippocampal activation supported memory. These results suggest that self-similarity influences evaluation and memory for targets but also affects the underlying neural resources engaged when thinking about others who vary in self-similarity.

  14. Initial eye movements during face identification are optimal and similar across cultures

    PubMed Central

    Or, Charles C.-F.; Peterson, Matthew F.; Eckstein, Miguel P.

    2015-01-01

    Culture influences not only human high-level cognitive processes but also low-level perceptual operations. Some perceptual operations, such as initial eye movements to faces, are critical for extraction of information supporting evolutionarily important tasks such as face identification. The extent of cultural effects on these crucial perceptual processes is unknown. Here, we report that the first gaze location for face identification was similar across East Asian and Western Caucasian cultural groups: Both fixated a featureless point between the eyes and the nose, with smaller between-group than within-group differences and with a small horizontal difference across cultures (8% of the interocular distance). We also show that individuals of both cultural groups initially fixated at a slightly higher point on Asian faces than on Caucasian faces. The initial fixations were found to be both fundamental in acquiring the majority of information for face identification and optimal, as accuracy deteriorated when observers held their gaze away from their preferred fixations. An ideal observer that integrated facial information with the human visual system's varying spatial resolution across the visual field showed a similar information distribution across faces of both races and predicted initial human fixations. The model consistently replicated the small vertical difference between human fixations to Asian and Caucasian faces but did not predict the small horizontal leftward bias of Caucasian observers. Together, the results suggest that initial eye movements during face identification may be driven by brain mechanisms aimed at maximizing accuracy, and less influenced by culture. The findings increase our understanding of the interplay between the brain's aims to optimally accomplish basic perceptual functions and to respond to sociocultural influences. PMID:26382003

  15. Improving structural similarity based virtual screening using background knowledge

    PubMed Central

    2013-01-01

    Background Virtual screening in the form of similarity rankings is often applied in the early drug discovery process to rank and prioritize compounds from a database. This similarity ranking can be achieved with structural similarity measures. However, their general nature can lead to insufficient performance in some application cases. In this paper, we provide a link between ranking-based virtual screening and fragment-based data mining methods. The inclusion of binding-relevant background knowledge into a structural similarity measure improves the quality of the similarity rankings. This background knowledge in the form of binding relevant substructures can either be derived by hand selection or by automated fragment-based data mining methods. Results In virtual screening experiments we show that our approach clearly improves enrichment factors with both applied variants of our approach: the extension of the structural similarity measure with background knowledge in the form of a hand-selected relevant substructure or the extension of the similarity measure with background knowledge derived with data mining methods. Conclusion Our study shows that adding binding relevant background knowledge can lead to significantly improved similarity rankings in virtual screening and that even basic data mining approaches can lead to competitive results making hand-selection of the background knowledge less crucial. This is especially important in drug discovery and development projects where no receptor structure is available or more frequently no verified binding mode is known and mostly ligand based approaches can be applied to generate hit compounds. PMID:24341870

  16. Similarity Search for Continuous Seismic Data

    NASA Astrophysics Data System (ADS)

    OReilly, O. J.; Yoon, C. E.; Beroza, G. C.

    2013-12-01

    Cross-correlation of seismic data streams with a priori known waveform templates has emerged as an effective tool to identify the occurrence of similar seismic signals; yet, this approach is difficult if the form of the templates is unknown. This challenge has been partially met by constructing waveform templates using reoccurring seismic signals sharing similar waveforms. This waveform similarity arises because the Earth's structure is essentially time invariant at the temporal scales considered in seismology. The problem of finding similar waveforms without known templates has been approached previously by segmenting incoming seismic data streams into multiple overlapping windows, each with a fixed length and lag, followed by matched filtering using each window as a template. An immediate shortcoming of this strategy is that it is computationally expensive; it scales quadratically with the number of lags needed, which limits the analysis to time series of short duration. The principal concept behind our approach, which enables scalable similarity search is to use a hierarchical approach to investigate only a small, near-constant sized subset of all possible waveform pairs for each query. In computer science and related fields, there are efficient techniques to solve this problem, which appears in numerous applications. Here, we bring these techniques into detection seismology. As a first step, we present a prototype database application that relies on a fingerprinting scheme that produces numerous high-dimensional sparse binary data representations of the windowed data streams (each fingerprint is significantly compressed compared to the actual window). These fingerprints encode key features of the actual window, enabling comparison among fingerprints rather than cross-correlating windows for comparison. Further dimensionality reduction is then applied to each fingerprint and similar fingerprints are grouped together using locality-sensitive hashing. Developing

  17. Similarity Metrics for Closed Loop Dynamic Systems

    NASA Technical Reports Server (NTRS)

    Whorton, Mark S.; Yang, Lee C.; Bedrossian, Naz; Hall, Robert A.

    2008-01-01

    To what extent and in what ways can two closed-loop dynamic systems be said to be "similar?" This question arises in a wide range of dynamic systems modeling and control system design applications. For example, bounds on error models are fundamental to the controller optimization with modern control design methods. Metrics such as the structured singular value are direct measures of the degree to which properties such as stability or performance are maintained in the presence of specified uncertainties or variations in the plant model. Similarly, controls-related areas such as system identification, model reduction, and experimental model validation employ measures of similarity between multiple realizations of a dynamic system. Each area has its tools and approaches, with each tool more or less suited for one application or the other. Similarity in the context of closed-loop model validation via flight test is subtly different from error measures in the typical controls oriented application. Whereas similarity in a robust control context relates to plant variation and the attendant affect on stability and performance, in this context similarity metrics are sought that assess the relevance of a dynamic system test for the purpose of validating the stability and performance of a "similar" dynamic system. Similarity in the context of system identification is much more relevant than are robust control analogies in that errors between one dynamic system (the test article) and another (the nominal "design" model) are sought for the purpose of bounding the validity of a model for control design and analysis. Yet system identification typically involves open-loop plant models which are independent of the control system (with the exception of limited developments in closed-loop system identification which is nonetheless focused on obtaining open-loop plant models from closed-loop data). Moreover the objectives of system identification are not the same as a flight test and

  18. MODIS Validation, Data Merger and Other Activities Accomplished by the SIMBIOS Project: 2002-2003

    NASA Technical Reports Server (NTRS)

    Fargion, Giulietta S.; McClain, Charles R.

    2003-01-01

    The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, satellite data processing, and data product validation. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report focuses on the SIMBIOS Project s efforts in support of the Moderate-Resolution Imaging Spectroradiometer (MODIS) on the Earth Observing System (EOS) Terra platform (similar evaluations of MODIS/Aqua are underway). This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

  19. Earthquake detection through computationally efficient similarity search.

    PubMed

    Yoon, Clara E; O'Reilly, Ossian; Bergen, Karianne J; Beroza, Gregory C

    2015-12-01

    Seismology is experiencing rapid growth in the quantity of data, which has outpaced the development of processing algorithms. Earthquake detection-identification of seismic events in continuous data-is a fundamental operation for observational seismology. We developed an efficient method to detect earthquakes using waveform similarity that overcomes the disadvantages of existing detection methods. Our method, called Fingerprint And Similarity Thresholding (FAST), can analyze a week of continuous seismic waveform data in less than 2 hours, or 140 times faster than autocorrelation. FAST adapts a data mining algorithm, originally designed to identify similar audio clips within large databases; it first creates compact "fingerprints" of waveforms by extracting key discriminative features, then groups similar fingerprints together within a database to facilitate fast, scalable search for similar fingerprint pairs, and finally generates a list of earthquake detections. FAST detected most (21 of 24) cataloged earthquakes and 68 uncataloged earthquakes in 1 week of continuous data from a station located near the Calaveras Fault in central California, achieving detection performance comparable to that of autocorrelation, with some additional false detections. FAST is expected to realize its full potential when applied to extremely long duration data sets over a distributed network of seismic stations. The widespread application of FAST has the potential to aid in the discovery of unexpected seismic signals, improve seismic monitoring, and promote a greater understanding of a variety of earthquake processes. PMID:26665176

  20. Earthquake detection through computationally efficient similarity search

    PubMed Central

    Yoon, Clara E.; O’Reilly, Ossian; Bergen, Karianne J.; Beroza, Gregory C.

    2015-01-01

    Seismology is experiencing rapid growth in the quantity of data, which has outpaced the development of processing algorithms. Earthquake detection—identification of seismic events in continuous data—is a fundamental operation for observational seismology. We developed an efficient method to detect earthquakes using waveform similarity that overcomes the disadvantages of existing detection methods. Our method, called Fingerprint And Similarity Thresholding (FAST), can analyze a week of continuous seismic waveform data in less than 2 hours, or 140 times faster than autocorrelation. FAST adapts a data mining algorithm, originally designed to identify similar audio clips within large databases; it first creates compact “fingerprints” of waveforms by extracting key discriminative features, then groups similar fingerprints together within a database to facilitate fast, scalable search for similar fingerprint pairs, and finally generates a list of earthquake detections. FAST detected most (21 of 24) cataloged earthquakes and 68 uncataloged earthquakes in 1 week of continuous data from a station located near the Calaveras Fault in central California, achieving detection performance comparable to that of autocorrelation, with some additional false detections. FAST is expected to realize its full potential when applied to extremely long duration data sets over a distributed network of seismic stations. The widespread application of FAST has the potential to aid in the discovery of unexpected seismic signals, improve seismic monitoring, and promote a greater understanding of a variety of earthquake processes. PMID:26665176

  1. Earthquake detection through computationally efficient similarity search.

    PubMed

    Yoon, Clara E; O'Reilly, Ossian; Bergen, Karianne J; Beroza, Gregory C

    2015-12-01

    Seismology is experiencing rapid growth in the quantity of data, which has outpaced the development of processing algorithms. Earthquake detection-identification of seismic events in continuous data-is a fundamental operation for observational seismology. We developed an efficient method to detect earthquakes using waveform similarity that overcomes the disadvantages of existing detection methods. Our method, called Fingerprint And Similarity Thresholding (FAST), can analyze a week of continuous seismic waveform data in less than 2 hours, or 140 times faster than autocorrelation. FAST adapts a data mining algorithm, originally designed to identify similar audio clips within large databases; it first creates compact "fingerprints" of waveforms by extracting key discriminative features, then groups similar fingerprints together within a database to facilitate fast, scalable search for similar fingerprint pairs, and finally generates a list of earthquake detections. FAST detected most (21 of 24) cataloged earthquakes and 68 uncataloged earthquakes in 1 week of continuous data from a station located near the Calaveras Fault in central California, achieving detection performance comparable to that of autocorrelation, with some additional false detections. FAST is expected to realize its full potential when applied to extremely long duration data sets over a distributed network of seismic stations. The widespread application of FAST has the potential to aid in the discovery of unexpected seismic signals, improve seismic monitoring, and promote a greater understanding of a variety of earthquake processes.

  2. Efficient Video Similarity Measurement and Search

    SciTech Connect

    Cheung, S-C S

    2002-12-19

    The amount of information on the world wide web has grown enormously since its creation in 1990. Duplication of content is inevitable because there is no central management on the web. Studies have shown that many similar versions of the same text documents can be found throughout the web. This redundancy problem is more severe for multimedia content such as web video sequences, as they are often stored in multiple locations and different formats to facilitate downloading and streaming. Similar versions of the same video can also be found, unknown to content creators, when web users modify and republish original content using video editing tools. Identifying similar content can benefit many web applications and content owners. For example, it will reduce the number of similar answers to a web search and identify inappropriate use of copyright content. In this dissertation, they present a system architecture and corresponding algorithms to efficiently measure, search, and organize similar video sequences found on any large database such as the web.

  3. Average is boring: how similarity kills a meme's success.

    PubMed

    Coscia, Michele

    2014-01-01

    Every day we are exposed to different ideas, or memes, competing with each other for our attention. Previous research explained popularity and persistence heterogeneity of memes by assuming them in competition for limited attention resources, distributed in a heterogeneous social network. Little has been said about what characteristics make a specific meme more likely to be successful. We propose a similarity-based explanation: memes with higher similarity to other memes have a significant disadvantage in their potential popularity. We employ a meme similarity measure based on semantic text analysis and computer vision to prove that a meme is more likely to be successful and to thrive if its characteristics make it unique. Our results show that indeed successful memes are located in the periphery of the meme similarity space and that our similarity measure is a promising predictor of a meme success. PMID:25257730

  4. Distributed Efficient Similarity Search Mechanism in Wireless Sensor Networks

    PubMed Central

    Ahmed, Khandakar; Gregory, Mark A.

    2015-01-01

    The Wireless Sensor Network similarity search problem has received considerable research attention due to sensor hardware imprecision and environmental parameter variations. Most of the state-of-the-art distributed data centric storage (DCS) schemes lack optimization for similarity queries of events. In this paper, a DCS scheme with metric based similarity searching (DCSMSS) is proposed. DCSMSS takes motivation from vector distance index, called iDistance, in order to transform the issue of similarity searching into the problem of an interval search in one dimension. In addition, a sector based distance routing algorithm is used to efficiently route messages. Extensive simulation results reveal that DCSMSS is highly efficient and significantly outperforms previous approaches in processing similarity search queries. PMID:25751081

  5. Universal self-similarity of propagating populations.

    PubMed

    Eliazar, Iddo; Klafter, Joseph

    2010-07-01

    This paper explores the universal self-similarity of propagating populations. The following general propagation model is considered: particles are randomly emitted from the origin of a d-dimensional Euclidean space and propagate randomly and independently of each other in space; all particles share a statistically common--yet arbitrary--motion pattern; each particle has its own random propagation parameters--emission epoch, motion frequency, and motion amplitude. The universally self-similar statistics of the particles' displacements and first passage times (FPTs) are analyzed: statistics which are invariant with respect to the details of the displacement and FPT measurements and with respect to the particles' underlying motion pattern. Analysis concludes that the universally self-similar statistics are governed by Poisson processes with power-law intensities and by the Fréchet and Weibull extreme-value laws.

  6. Universal self-similarity of propagating populations

    NASA Astrophysics Data System (ADS)

    Eliazar, Iddo; Klafter, Joseph

    2010-07-01

    This paper explores the universal self-similarity of propagating populations. The following general propagation model is considered: particles are randomly emitted from the origin of a d -dimensional Euclidean space and propagate randomly and independently of each other in space; all particles share a statistically common—yet arbitrary—motion pattern; each particle has its own random propagation parameters—emission epoch, motion frequency, and motion amplitude. The universally self-similar statistics of the particles’ displacements and first passage times (FPTs) are analyzed: statistics which are invariant with respect to the details of the displacement and FPT measurements and with respect to the particles’ underlying motion pattern. Analysis concludes that the universally self-similar statistics are governed by Poisson processes with power-law intensities and by the Fréchet and Weibull extreme-value laws.

  7. Similar biotherapeutic products: overview and reflections.

    PubMed

    Desanvicente-Celis, Zayrho; Gomez-Lopez, Arley; Anaya, Juan-Manuel

    2012-12-01

    Biotherapeutic products (BPs) have revolutionized medicine, changing the way we treat several pathologies such as autoimmune diseases and cancer, among others. Herein, we present an overview of similar BPs (SBPs), also called biosimilars, including the manufacturing process and regulatory aspects involved. The objective of developing an SBP is to manufacture a molecule that is highly similar to a reference BP by conducting a comparability exercise (CE) that can demonstrate similar safety and efficacy. This CE consists of quality, as well as nonclinical and clinical evaluation. A case-by-case analysis approach guided by scientific and objective standards must be the foundation for the SBP approval process. The establishment of a balance between a comprehensive CE for SBPs and their reference BPs, and the design of costeffective strategies to provide better access to BPs, should be the key goal for national regulatory authorities. PMID:23240752

  8. Quantifying the similarity of seismic polarizations

    NASA Astrophysics Data System (ADS)

    Jones, Joshua P.; Eaton, David W.; Caffagni, Enrico

    2016-02-01

    Assessing the similarities of seismic attributes can help identify tremor, low signal-to-noise (S/N) signals and converted or reflected phases, in addition to diagnosing site noise and sensor misalignment in arrays. Polarization analysis is a widely accepted method for studying the orientation and directional characteristics of seismic phases via computed attributes, but similarity is ordinarily discussed using qualitative comparisons with reference values or known seismic sources. Here we introduce a technique for quantitative polarization similarity that uses weighted histograms computed in short, overlapping time windows, drawing on methods adapted from the image processing and computer vision literature. Our method accounts for ambiguity in azimuth and incidence angle and variations in S/N ratio. Measuring polarization similarity allows easy identification of site noise and sensor misalignment and can help identify coherent noise and emergent or low S/N phase arrivals. Dissimilar azimuths during phase arrivals indicate misaligned horizontal components, dissimilar incidence angles during phase arrivals indicate misaligned vertical components and dissimilar linear polarization may indicate a secondary noise source. Using records of the Mw = 8.3 Sea of Okhotsk earthquake, from Canadian National Seismic Network broad-band sensors in British Columbia and Yukon Territory, Canada, and a vertical borehole array at Hoadley gas field, central Alberta, Canada, we demonstrate that our method is robust to station spacing. Discrete wavelet analysis extends polarization similarity to the time-frequency domain in a straightforward way. Time-frequency polarization similarities of borehole data suggest that a coherent noise source may have persisted above 8 Hz several months after peak resource extraction from a `flowback' type hydraulic fracture.

  9. Some more similarities between Peirce and Skinner

    PubMed Central

    Moxley, Roy A.

    2002-01-01

    C. S. Peirce is noted for pioneering a variety of views, and the case is made here for the similarities and parallels between his views and B. F. Skinner's radical behaviorism. In addition to parallels previously noted, these similarities include an advancement of experimental science, a behavioral psychology, a shift from nominalism to realism, an opposition to positivism, a selectionist account for strengthening behavior, the importance of a community of selves, a recursive approach to method, and the probabilistic nature of truth. Questions are raised as to the extent to which Skinner's radical behaviorism, as distinguished from his S-R positivism, may be seen as an extension of Peirce's pragmatism. PMID:22478387

  10. Random walks with similar transition probabilities

    NASA Astrophysics Data System (ADS)

    Schiefermayr, Klaus

    2003-04-01

    We consider random walks on the nonnegative integers with a possible absorbing state at -1. A random walk is called [alpha]-similar to a random walk if there exist constants Cij such that for the corresponding n-step transition probabilities , i,j[greater-or-equal, slanted]0, hold. We give necessary and sufficient conditions for the [alpha]-similarity of two random walks both in terms of the parameters and in terms of the corresponding spectral measures which appear in the spectral representation of the n-step transition probabilities developed by Karlin and McGregor.

  11. The collagenous gastroenteritides: similarities and differences.

    PubMed

    Gopal, Purva; McKenna, Barbara J

    2010-10-01

    Collagenous gastritis, collagenous sprue, and collagenous colitis share striking histologic similarities and occur together in some patients. They also share some drug and disease associations. Pediatric cases of collagenous gastritis, however, lack most of these associations. The etiologies of the collagenous gastroenteritides are not known, so it is not clear whether they are similar because they share pathogeneses, or because they indicate a common histologic response to varying injuries. The features, disease and drug associations, and the inquiries into the pathogenesis of these disorders are reviewed. PMID:20923305

  12. Semantic similarity measure in biomedical domain leverage web search engine.

    PubMed

    Chen, Chi-Huang; Hsieh, Sheau-Ling; Weng, Yung-Ching; Chang, Wen-Yung; Lai, Feipei

    2010-01-01

    Semantic similarity measure plays an essential role in Information Retrieval and Natural Language Processing. In this paper we propose a page-count-based semantic similarity measure and apply it in biomedical domains. Previous researches in semantic web related applications have deployed various semantic similarity measures. Despite the usefulness of the measurements in those applications, measuring semantic similarity between two terms remains a challenge task. The proposed method exploits page counts returned by the Web Search Engine. We define various similarity scores for two given terms P and Q, using the page counts for querying P, Q and P AND Q. Moreover, we propose a novel approach to compute semantic similarity using lexico-syntactic patterns with page counts. These different similarity scores are integrated adapting support vector machines, to leverage the robustness of semantic similarity measures. Experimental results on two datasets achieve correlation coefficients of 0.798 on the dataset provided by A. Hliaoutakis, 0.705 on the dataset provide by T. Pedersen with physician scores and 0.496 on the dataset provided by T. Pedersen et al. with expert scores.

  13. FunSimMat: a comprehensive functional similarity database.

    PubMed

    Schlicker, Andreas; Albrecht, Mario

    2008-01-01

    Functional similarity based on Gene Ontology (GO) annotation is used in diverse applications like gene clustering, gene expression data analysis, protein interaction prediction and evaluation. However, there exists no comprehensive resource of functional similarity values although such a database would facilitate the use of functional similarity measures in different applications. Here, we describe FunSimMat (Functional Similarity Matrix, http://funsimmat.bioinf.mpi-inf.mpg.de/), a large new database that provides several different semantic similarity measures for GO terms. It offers various precomputed functional similarity values for proteins contained in UniProtKB and for protein families in Pfam and SMART. The web interface allows users to efficiently perform both semantic similarity searches with GO terms and functional similarity searches with proteins or protein families. All results can be downloaded in tab-delimited files for use with other tools. An additional XML-RPC interface gives automatic online access to FunSimMat for programs and remote services.

  14. Investigation of psychophysical similarity measures for selection of similar images in the diagnosis of clustered microcalcifications on mammograms

    SciTech Connect

    Muramatsu, Chisako; Li Qiang; Schmidt, Robert; Shiraishi, Junji; Doi, Kunio

    2008-12-15

    coefficient between the gold standard and the psychophysical similarity measure through the use of seven features was relatively high (r=0.71) and was comparable to the correlation coefficients between the ratings by one radiologist and the average ratings by nine radiologists (r=0.69{+-}0.07). The correlation coefficient was improved compared to that of a distance-based method (r=0.58). The result indicated that similar images selected by the psychophysical similarity measure may be useful to radiologists in the diagnosis of clustered microcalcifications on mammograms.

  15. Representational Similarity of Body Parts in Human Occipitotemporal Cortex.

    PubMed

    Bracci, Stefania; Caramazza, Alfonso; Peelen, Marius V

    2015-09-23

    Regions in human lateral and ventral occipitotemporal cortices (OTC) respond selectively to pictures of the human body and its parts. What are the organizational principles underlying body part responses in these regions? Here we used representational similarity analysis (RSA) of fMRI data to test multiple possible organizational principles: shape similarity, physical proximity, cortical homunculus proximity, and semantic similarity. Participants viewed pictures of whole persons, chairs, and eight body parts (hands, arms, legs, feet, chests, waists, upper faces, and lower faces). The similarity of multivoxel activity patterns for all body part pairs was established in whole person-selective OTC regions. The resulting neural similarity matrices were then compared with similarity matrices capturing the hypothesized organizational principles. Results showed that the semantic similarity model best captured the neural similarity of body parts in lateral and ventral OTC, which followed an organization in three clusters: (1) body parts used as action effectors (hands, feet, arms, and legs), (2) noneffector body parts (chests and waists), and (3) face parts (upper and lower faces). Whole-brain RSA revealed, in addition to OTC, regions in parietal and frontal cortex in which neural similarity was related to semantic similarity. In contrast, neural similarity in occipital cortex was best predicted by shape similarity models. We suggest that the semantic organization of body parts in high-level visual cortex relates to the different functions associated with the three body part clusters, reflecting the unique processing and connectivity demands associated with the different types of information (e.g., action, social) different body parts (e.g., limbs, faces) convey. Significance statement: While the organization of body part representations in motor and somatosensory cortices has been well characterized, the principles underlying body part representations in visual cortex

  16. Representational Similarity of Body Parts in Human Occipitotemporal Cortex.

    PubMed

    Bracci, Stefania; Caramazza, Alfonso; Peelen, Marius V

    2015-09-23

    Regions in human lateral and ventral occipitotemporal cortices (OTC) respond selectively to pictures of the human body and its parts. What are the organizational principles underlying body part responses in these regions? Here we used representational similarity analysis (RSA) of fMRI data to test multiple possible organizational principles: shape similarity, physical proximity, cortical homunculus proximity, and semantic similarity. Participants viewed pictures of whole persons, chairs, and eight body parts (hands, arms, legs, feet, chests, waists, upper faces, and lower faces). The similarity of multivoxel activity patterns for all body part pairs was established in whole person-selective OTC regions. The resulting neural similarity matrices were then compared with similarity matrices capturing the hypothesized organizational principles. Results showed that the semantic similarity model best captured the neural similarity of body parts in lateral and ventral OTC, which followed an organization in three clusters: (1) body parts used as action effectors (hands, feet, arms, and legs), (2) noneffector body parts (chests and waists), and (3) face parts (upper and lower faces). Whole-brain RSA revealed, in addition to OTC, regions in parietal and frontal cortex in which neural similarity was related to semantic similarity. In contrast, neural similarity in occipital cortex was best predicted by shape similarity models. We suggest that the semantic organization of body parts in high-level visual cortex relates to the different functions associated with the three body part clusters, reflecting the unique processing and connectivity demands associated with the different types of information (e.g., action, social) different body parts (e.g., limbs, faces) convey. Significance statement: While the organization of body part representations in motor and somatosensory cortices has been well characterized, the principles underlying body part representations in visual cortex

  17. Estimating the self-similar exponent of broad-sense self-similar processes

    NASA Astrophysics Data System (ADS)

    Zheng, Jing; Zhang, Guijun; Tong, Changqing

    2016-02-01

    In this paper, a new algorithm about the self-similar exponent of self-similar processes is introduced which is used to explore long memory in financial time series. This method can work for more general broad-sense self-similar processes. We prove that this algorithm performs much better than the classical methods.

  18. Great Apes' Capacities to Recognize Relational Similarity

    ERIC Educational Resources Information Center

    Haun, Daniel B. M.; Call, Josep

    2009-01-01

    Recognizing relational similarity relies on the ability to understand that defining object properties might not lie in the objects individually, but in the relations of the properties of various object to each other. This aptitude is highly relevant for many important human skills such as language, reasoning, categorization and understanding…

  19. Building structural similarity database for metric learning

    NASA Astrophysics Data System (ADS)

    Jin, Guoxin; Pappas, Thrasyvoulos N.

    2015-03-01

    We propose a new approach for constructing databases for training and testing similarity metrics for structurally lossless image compression. Our focus is on structural texture similarity (STSIM) metrics and the matched-texture compression (MTC) approach. We first discuss the metric requirements for structurally lossless compression, which differ from those of other applications such as image retrieval, classification, and understanding. We identify "interchangeability" as the key requirement for metric performance, and partition the domain of "identical" textures into three regions, of "highest," "high," and "good" similarity. We design two subjective tests for data collection, the first relies on ViSiProG to build a database of "identical" clusters, and the second builds a database of image pairs with the "highest," "high," "good," and "bad" similarity labels. The data for the subjective tests is generated during the MTC encoding process, and consist of pairs of candidate and target image blocks. The context of the surrounding image is critical for training the metrics to detect lighting discontinuities, spatial misalignments, and other border artifacts that have a noticeable effect on perceptual quality. The identical texture clusters are then used for training and testing two STSIM metrics. The labelled image pair database will be used in future research.

  20. The Case of the Similar Trees.

    ERIC Educational Resources Information Center

    Meyer, Rochelle Wilson

    1982-01-01

    A possible logical flaw based on similar triangles is discussed with the Sherlock Holmes mystery, "The Muskgrave Ritual." The possible flaw has to do with the need for two trees to have equal growth rates over a 250-year period in order for the solution presented to work. (MP)

  1. Self-similar parabolic plasmonic beams.

    PubMed

    Davoyan, Arthur R; Turitsyn, Sergei K; Kivshar, Yuri S

    2013-02-15

    We demonstrate that an interplay between diffraction and defocusing nonlinearity can support stable self-similar plasmonic waves with a parabolic profile. Simplicity of a parabolic shape combined with the corresponding parabolic spatial phase distribution creates opportunities for controllable manipulation of plasmons through a combined action of diffraction and nonlinearity.

  2. Similarity of Science Textbooks: A Content Analysis

    ERIC Educational Resources Information Center

    Yost, Michael

    1973-01-01

    Studied the similarity of the astronomy portion in five science textbooks at the fourth through sixth grade levels by comparing students' responses to text authors' requirements. Concluded that the texts had more in common across grade levels than within grade levels. (CC)

  3. Predicting spatial similarity of freshwater fish biodiversity

    PubMed Central

    Azaele, Sandro; Muneepeerakul, Rachata; Maritan, Amos; Rinaldo, Andrea; Rodriguez-Iturbe, Ignacio

    2009-01-01

    A major issue in modern ecology is to understand how ecological complexity at broad scales is regulated by mechanisms operating at the organismic level. What specific underlying processes are essential for a macroecological pattern to emerge? Here, we analyze the analytical predictions of a general model suitable for describing the spatial biodiversity similarity in river ecosystems, and benchmark them against the empirical occurrence data of freshwater fish species collected in the Mississippi–Missouri river system. Encapsulating immigration, emigration, and stochastic noise, and without resorting to species abundance data, the model is able to reproduce the observed probability distribution of the Jaccard similarity index at any given distance. In addition to providing an excellent agreement with the empirical data, this approach accounts for heterogeneities of different subbasins, suggesting a strong dependence of biodiversity similarity on their respective climates. Strikingly, the model can also predict the actual probability distribution of the Jaccard similarity index for any distance when considering just a relatively small sample. The proposed framework supports the notion that simplified macroecological models are capable of predicting fundamental patterns—a theme at the heart of modern community ecology. PMID:19359481

  4. Parents' School Satisfaction: Ethnic Similarities and Differences

    ERIC Educational Resources Information Center

    Friedman, Barry A.; Bobrowski, Paula E.; Geraci, John

    2006-01-01

    Purpose: Parent satisfaction with their children's school is an important issue in today's competitive educational environment characterized by school choice and government standards; however, few empirical studies address school satisfaction similarities and differences among parents from different ethnic groups. The purpose of this paper is to…

  5. Selecting the Right Similarity-Scoring Matrix.

    PubMed

    Pearson, William R

    2013-01-01

    Protein sequence similarity searching programs like BLASTP, SSEARCH (UNIT 3.10), and FASTA use scoring matrices that are designed to identify distant evolutionary relationships (BLOSUM62 for BLAST, BLOSUM50 for SEARCH and FASTA). Different similarity scoring matrices are most effective at different evolutionary distances. "Deep" scoring matrices like BLOSUM62 and BLOSUM50 target alignments with 20 - 30% identity, while "shallow" scoring matrices (e.g. VTML10 - VTML80), target alignments that share 90 - 50% identity, reflecting much less evolutionary change. While "deep" matrices provide very sensitive similarity searches, they also require longer sequence alignments and can sometimes produce alignment overextension into non-homologous regions. Shallower scoring matrices are more effective when searching for short protein domains, or when the goal is to limit the scope of the search to sequences that are likely to be orthologous between recently diverged organisms. Likewise, in DNA searches, the match and mismatch parameters set evolutionary look-back times and domain boundaries. In this unit, we will discuss the theoretical foundations that drive practical choices of protein and DNA similarity scoring matrices and gap penalties. Deep scoring matrices (BLOSUM62 and BLOSUM50) should be used for sensitive searches with full-length protein sequences, but short domains or restricted evolutionary look-back require shallower scoring matrices.

  6. Similarity and rules: distinct? Exhaustive? Empirically distinguishable?

    PubMed

    Hahn, U; Chater, N

    1998-01-01

    The distinction between rule-based and similarity-based processes in cognition is of fundamental importance for cognitive science, and has been the focus of a large body of empirical research. However, intuitive uses of the distinction are subject to theoretical difficulties and their relation to empirical evidence is not clear. We propose a 'core' distinction between rule- and similarity-based processes, in terms of the way representations of stored information are 'matched' with the representation of a novel item. This explication captures the intuitively clear-cut cases of processes of each type, and resolves apparent problems with the rule/similarity distinction. Moreover, it provides a clear target for assessing the psychological and AI literatures. We show that many lines of psychological evidence are less conclusive than sometimes assumed, but suggest that converging lines of evidence may be persuasive. We then argue that the AI literature suggests that approaches which combine rules and similarity are an important new focus for empirical work.

  7. Self similar nonlocal electron heat flow

    NASA Astrophysics Data System (ADS)

    Matte, Jean-Pierre

    2007-11-01

    The well known self similar heat diffusion solutions of Zel'dovich and Raizer [1], for a heat wave advancing from a boundary at a fixed temperature or a fixed heat flux do not keep the ratio R of the scale length to the mean free path constant. Instead, R increases and the solution becomes increasingly valid because Spitzer-Harm [2] heat flow is increasingly applicable. A self similar solution exists which keeps R constant, if one assumes that the boundary heat flux increases in time. Similarly, for the problem of a uniform density plasma heated by a finite width laser beam, a self similar solution keeping R constant can be obtained by assuming that the beam intensity and width increase in time. Such solutions will be studied with the electron kinetic code FPI [3], and compared to simulations with more usual laser characteristics. [1] Ya. B. Zel'dovich and Yu. P. Raizer, ``Physics of Shock Waves '', Academic Press, New York, 1967. [2] L. Spitzer and R. Harm, Phys. Rev. 89, 977 (1953). [3] J.-P. Matte et al., Phys. Rev. Lett. 53, 1461 (1984) ; ibid 49, 1936 (1982).

  8. Annular self-similar solutions in ideal magnetogasdynamics

    NASA Astrophysics Data System (ADS)

    Lock, R. M.; Mestel, A. J.

    2008-08-01

    We consider the possibility of self-similar solutions describing the implosion of hollow cylindrical annuli driven by an azimuthal magnetic field, in essence a self-similar imploding liner z-pinch. We construct such solutions for gasdynamics, for ideal ‘β=0’ plasma and for ideal magnetogasdynamics (MGD). In the latter two cases some quantities are singular at the annular boundaries. Numerical solutions of the full ideal MGD initial value problem indicate that the self-similar solutions are not attractive for arbitrary initial conditions, possibly as a result of flux-freezing.

  9. Conceptual similarity promotes generalization of higher order fear learning

    PubMed Central

    Dunsmoor, Joseph E.; White, Allison J.; LaBar, Kevin S.

    2011-01-01

    We tested the hypothesis that conceptual similarity promotes generalization of conditioned fear. Using a sensory preconditioning procedure, three groups of subjects learned an association between two cues that were conceptually similar, unrelated, or mismatched. Next, one of the cues was paired with a shock. The other cue was then reintroduced to test for fear generalization, as measured by the skin conductance response. Results showed enhanced fear generalization that correlated with trait anxiety levels in the group that learned an association between conceptually similar stimuli. These findings suggest that conceptual representations of conditional stimuli influence human fear learning processes. PMID:21330378

  10. A Short Survey of Document Structure Similarity Algorithms

    SciTech Connect

    Buttler, D

    2004-02-27

    This paper provides a brief survey of document structural similarity algorithms, including the optimal Tree Edit Distance algorithm and various approximation algorithms. The approximation algorithms include the simple weighted tag similarity algorithm, Fourier transforms of the structure, and a new application of the shingle technique to structural similarity. We show three surprising results. First, the Fourier transform technique proves to be the least accurate of any of approximation algorithms, while also being slowest. Second, optimal Tree Edit Distance algorithms may not be the best technique for clustering pages from different sites. Third, the simplest approximation to structure may be the most effective and efficient mechanism for many applications.

  11. Diagnosis Mechanism and Feedback System to Accomplish the Full-Loop Learning Architecture

    ERIC Educational Resources Information Center

    Heh, Jia-Sheng; Li, Shao-Chun; Chang, Alex; Chang, Maiga; Liu, Tzu-Chien

    2008-01-01

    Students in network-based learning environments may have their own learning paths based on either their learning results or status. The learning system can choose suitable learning materials for individual students depending on students' learning results. There is a lot of research about learning diagnosis in distance education, and the main…

  12. Structural dynamics division research and technology accomplishments for F.Y. 1991 and plans for F.Y. 1992

    NASA Technical Reports Server (NTRS)

    Wynne, Eleanor C.

    1992-01-01

    The work under each technical area is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5 year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest. The structural dynamics division consist of the following branches: configuration aeroelasticity; unsteady aerodynamics; aeroservoelasticity; landing and impact dynamics; and spacecraft dynamics.

  13. Self-similar solitary waves in Bessel optical lattices

    SciTech Connect

    Xu Siliu; Liang Jianchu; Yi Lin

    2010-01-15

    An analytical solitary wave solution to the generalized nonlinear Schroedinger equation (NLSE) with varying coefficients in Bessel optical lattices is obtained based on the self-similar method. Our results indicate that a new family of Bessel (BSL) self-similar spatial solitons can be formed in the Kerr nonlinear media in the confined cylindrical symmetric geometry in sizes. These soliton profiles are rather stable, independent of propagation distance.

  14. Positive Psychology Interventions Addressing Pleasure, Engagement, Meaning, Positive Relationships, and Accomplishment Increase Well-Being and Ameliorate Depressive Symptoms: A Randomized, Placebo-Controlled Online Study.

    PubMed

    Gander, Fabian; Proyer, René T; Ruch, Willibald

    2016-01-01

    Seligman (2002) suggested three paths to well-being, the pursuit of pleasure, the pursuit of meaning, and the pursuit of engagement, later adding two more, positive relationships and accomplishment, in his 2011 version. The contribution of these new components to well-being has yet to be addressed. In an online positive psychology intervention study, we randomly assigned 1624 adults aged 18-78 (M = 46.13; 79.2% women) to seven conditions. Participants wrote down three things they related to either one of the five components of Seligman's Well-Being theory (Conditions 1-5), all of the five components (Condition 6) or early childhood memories (placebo control condition). We assessed happiness (AHI) and depression (CES-D) before and after the intervention, and 1-, 3-, and 6 months afterwards. Additionally, we considered moderation effects of well-being levels at baseline. Results confirmed that all interventions were effective in increasing happiness and most ameliorated depressive symptoms. The interventions worked best for those in the middle-range of the well-being continuum. We conclude that interventions based on pleasure, engagement, meaning, positive relationships, and accomplishment are effective strategies for increasing well-being and ameliorating depressive symptoms and that positive psychology interventions are most effective for those people in the middle range of the well-being continuum.

  15. Performance as Promised: How the Chandra X-ray Observatory Accomplished One of Nasa's Most Challenging Missions for Billions of Dollars Less than Originally Planned

    NASA Technical Reports Server (NTRS)

    Davidson, Greg; Hefner, Keith

    2004-01-01

    As the nation looks toward bold new ventures in space, the Chandra X-ray Observatory program offers an example of how billion-dollar missions can be successfully developed within tightening fiscal constraints. Chandra experienced many of challenges facing bold space programs (state-of-the-art technical requirements and budget-induced slips and restructurings), and yet the Chandra team achieved nearly all the originally envisioned performance for dramatically lower cost. This was accomplished by a combination of team- work, systems engineering, advanced technology insertion, and effective approaches for program implementation. A thorough tradeoff of science utility vs. cost led to the selection of a highly elliptical orbit with uncrewed robotic delivery, deployment, and maintenance. Progressive, focused technology demonstrations were accomplished prior to commitment of major resources to critical elements of the system design, such as the high resolution mirror assembly (HRMA). Pathfinder hardware was developed to reduce risks. A variety of schedule risk reduction measures were implemented and resulted in the X-ray calibration taking place exactly within five days of its originally planned date after after five years of development. The team worked together in an effective manner to contain requirements creep. reductions such as the ACIS-2 chip device. It is estimated that the above combination of measures achieved the avoidance of over $4B in costs, while enabling a highly successful mission.

  16. Positive Psychology Interventions Addressing Pleasure, Engagement, Meaning, Positive Relationships, and Accomplishment Increase Well-Being and Ameliorate Depressive Symptoms: A Randomized, Placebo-Controlled Online Study

    PubMed Central

    Gander, Fabian; Proyer, René T.; Ruch, Willibald

    2016-01-01

    Seligman (2002) suggested three paths to well-being, the pursuit of pleasure, the pursuit of meaning, and the pursuit of engagement, later adding two more, positive relationships and accomplishment, in his 2011 version. The contribution of these new components to well-being has yet to be addressed. In an online positive psychology intervention study, we randomly assigned 1624 adults aged 18–78 (M = 46.13; 79.2% women) to seven conditions. Participants wrote down three things they related to either one of the five components of Seligman's Well-Being theory (Conditions 1–5), all of the five components (Condition 6) or early childhood memories (placebo control condition). We assessed happiness (AHI) and depression (CES-D) before and after the intervention, and 1-, 3-, and 6 months afterwards. Additionally, we considered moderation effects of well-being levels at baseline. Results confirmed that all interventions were effective in increasing happiness and most ameliorated depressive symptoms. The interventions worked best for those in the middle-range of the well-being continuum. We conclude that interventions based on pleasure, engagement, meaning, positive relationships, and accomplishment are effective strategies for increasing well-being and ameliorating depressive symptoms and that positive psychology interventions are most effective for those people in the middle range of the well-being continuum. PMID:27242600

  17. Visual similarity is stronger than semantic similarity in guiding visual search for numbers.

    PubMed

    Godwin, Hayward J; Hout, Michael C; Menneer, Tamaryn

    2014-06-01

    Using a visual search task, we explored how behavior is influenced by both visual and semantic information. We recorded participants' eye movements as they searched for a single target number in a search array of single-digit numbers (0-9). We examined the probability of fixating the various distractors as a function of two key dimensions: the visual similarity between the target and each distractor, and the semantic similarity (i.e., the numerical distance) between the target and each distractor. Visual similarity estimates were obtained using multidimensional scaling based on the independent observer similarity ratings. A linear mixed-effects model demonstrated that both visual and semantic similarity influenced the probability that distractors would be fixated. However, the visual similarity effect was substantially larger than the semantic similarity effect. We close by discussing the potential value of using this novel methodological approach and the implications for both simple and complex visual search displays.

  18. Relations between twins' similarity of appearance and behavioral similarity: testing an assumption.

    PubMed

    Matheny, A P; Wilson, R S; Dolan, A B

    1976-07-01

    Questionnaires rating twins' physical similarity and similarity of dress were obtained from the parents of 121 identical and 70 same-sex fraternal twin pairs. Within-pair difference scores on several behavioral measures (two intelligence tests, two perceptual tests, one reading test, one test of speech articulation, and one personality inventory) were correlated with the twins' scores for physical similarity and similarity of dress. The correlations revealed no systematic relation between the similarity of appearance and the similarity of behaviors for either the identical twin pairs or the same-sex fraternal twin pairs. The assumption that twins' behaviors are more alike because they are more similar in appearance does not seem warranted.

  19. Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity

    PubMed Central

    Chen, Xing; Clarence Yan, Chenggang; Luo, Cai; Ji, Wen; Zhang, Yongdong; Dai, Qionghai

    2015-01-01

    Increasing evidence has indicated that plenty of lncRNAs play important roles in many critical biological processes. Developing powerful computational models to construct lncRNA functional similarity network based on heterogeneous biological datasets is one of the most important and popular topics in the fields of both lncRNAs and complex diseases. Functional similarity network consturction could benefit the model development for both lncRNA function inference and lncRNA-disease association identification. However, little effort has been attempted to analysis and calculate lncRNA functional similarity on a large scale. In this study, based on the assumption that functionally similar lncRNAs tend to be associated with similar diseases, we developed two novel lncRNA functional similarity calculation models (LNCSIM). LNCSIM was evaluated by introducing similarity scores into the model of Laplacian Regularized Least Squares for LncRNA–Disease Association (LRLSLDA) for lncRNA-disease association prediction. As a result, new predictive models improved the performance of LRLSLDA in the leave-one-out cross validation of various known lncRNA-disease associations datasets. Furthermore, some of the predictive results for colorectal cancer and lung cancer were verified by independent biological experimental studies. It is anticipated that LNCSIM could be a useful and important biological tool for human disease diagnosis, treatment, and prevention. PMID:26061969

  20. Selection of USSR foreign similarity regions

    NASA Technical Reports Server (NTRS)

    Disler, J. M. (Principal Investigator)

    1982-01-01

    The similarity regions in the United States and Canada were selected to parallel the conditions that affect labeling and classification accuracies in the U.S.S.R. indicator regions. In addition to climate, a significant condition that affects labeling and classification accuracies in the U.S.S.R. is the proportion of barley and wheat grown in a given region (based on sown areas). The following regions in the United States and Canada were determined to be similar to the U.S.S.R. indicator regions: (1) Montana agrophysical unit (APU) 104 corresponds to the Belorussia high barley region; (2) North Dakota and Minnesota APU 20 and secondary region southern Manitoba and Saskatchewan correspond to the Ural RSFSR barley and spring wheat region; (3) Montana APU 23 corresponds to he North Caucasus barley and winter wheat region. Selection criteria included climates, crop type, crop distribution, growth cycles, field sizes, and field shapes.

  1. Fracking in Tight Shales: What Is It, What Does It Accomplish, and What Are Its Consequences?

    NASA Astrophysics Data System (ADS)

    Norris, J. Quinn; Turcotte, Donald L.; Moores, Eldridge M.; Brodsky, Emily E.; Rundle, John B.

    2016-06-01

    Fracking is a popular term referring to hydraulic fracturing when it is used to extract hydrocarbons. We distinguish between low-volume traditional fracking and the high-volume modern fracking used to recover large volumes of hydrocarbons from shales. Shales are fine-grained rocks with low granular permeabilities. During the formation of oil and gas, large fluid pressures are generated. These pressures result in natural fracking, and the resulting fracture permeability allows oil and gas to escape, reducing the fluid pressures. These fractures may subsequently be sealed by mineral deposition, resulting in tight shale formations. The objective of modern fracking is to reopen these fractures and/or create new fractures on a wide range of scales. Modern fracking has had a major impact on the availability of oil and gas globally; however, there are serious environmental objections to modern fracking, which should be weighed carefully against its benefits.

  2. Fingerprint matching based on global comprehensive similarity.

    PubMed

    He, Yuliang; Tian, Jie; Li, Liang; Chen, Hong; Yang, Xin

    2006-06-01

    This paper introduces a novel algorithm based on global comprehensive similarity with three steps. To describe the Euclidean space-based relative features among minutiae, we first build a minutia-simplex that contains a pair of minutiae as well as their associated textures, with its transformation-variant and invariant relative features employed for the comprehensive similarity measurement and parameter estimation, respectively. By the second step, we use the ridge-based nearest neighborhood among minutiae to represent the ridge-based relative features among minutiae. With these ridge-based relative features, minutiae are grouped according to their affinity with a ridge. The Euclidean space-based and ridge-based relative features among minutiae reinforce each other in the representation of a fingerprint. Finally, we model the relationship between transformation and the comprehensive similarity between two fingerprints in terms of histogram for initial parameter estimation. Through these steps, our experiment shows that the method mentioned above is both effective and suitable for limited memory AFIS owing to its less than 1k byte template size. PMID:16724581

  3. Effects of similarity on environmental context cueing.

    PubMed

    Smith, Steven M; Handy, Justin D; Angello, Genna; Manzano, Isabel

    2014-01-01

    Three experiments examined the prediction that context cues which are similar to study contexts can facilitate episodic recall, even if those cues are never seen before the recall test. Environmental context cueing effects have typically produced such small effect sizes that influences of moderating factors, such as the similarity between encoding and retrieval contexts, would be difficult to observe experimentally. Videos of environmental contexts, however, can be used to produce powerful context-dependent memory effects, particularly when only one memory target is associated with each video context, intentional item-context encoding is encouraged, and free recall tests are used. Experiment 1 showed that a not previously viewed video of the study context provided an effective recall cue, although it was not as effective as the originally viewed video context. Experiments 2 and 3 showed that videos of environments that were conceptually similar to encoding contexts (e.g., both were videos of ball field games) also cued recall, but not as well if the encoding contexts were given specific labels (e.g., "home run") incompatible with test contexts (e.g., a soccer scene). A fourth experiment that used incidental item-context encoding showed that video context reinstatement has a robust effect on paired associate memory, indicating that the video context reinstatement effect does not depend on interactive item-context encoding or free recall testing.

  4. Effects of similarity on environmental context cueing.

    PubMed

    Smith, Steven M; Handy, Justin D; Angello, Genna; Manzano, Isabel

    2014-01-01

    Three experiments examined the prediction that context cues which are similar to study contexts can facilitate episodic recall, even if those cues are never seen before the recall test. Environmental context cueing effects have typically produced such small effect sizes that influences of moderating factors, such as the similarity between encoding and retrieval contexts, would be difficult to observe experimentally. Videos of environmental contexts, however, can be used to produce powerful context-dependent memory effects, particularly when only one memory target is associated with each video context, intentional item-context encoding is encouraged, and free recall tests are used. Experiment 1 showed that a not previously viewed video of the study context provided an effective recall cue, although it was not as effective as the originally viewed video context. Experiments 2 and 3 showed that videos of environments that were conceptually similar to encoding contexts (e.g., both were videos of ball field games) also cued recall, but not as well if the encoding contexts were given specific labels (e.g., "home run") incompatible with test contexts (e.g., a soccer scene). A fourth experiment that used incidental item-context encoding showed that video context reinstatement has a robust effect on paired associate memory, indicating that the video context reinstatement effect does not depend on interactive item-context encoding or free recall testing. PMID:23721293

  5. A motor similarity effect in object memory.

    PubMed

    Downing-Doucet, Frédéric; Guérard, Katherine

    2014-08-01

    In line with theories of embodied cognition (e.g., Versace et al. European Journal of Cognitive Psychology, 21, 522-560, 2009), several studies have suggested that the motor system used to interact with objects in our environment is involved in object recognition (e.g., Helbig, Graf, & Kiefer Experimental Brain Research, 174, 221-228, 2006). However, the role of the motor system in immediate memory for objects is more controversial. The objective of the present study was to investigate the role of the motor system in object memory by manipulating the similarity between the actions associated to series of objects to be retained in memory. In Experiment 1, we showed that lists of objects associated to dissimilar actions were better recalled than lists associated to similar actions. We then showed that this effect was abolished when participants were required to perform a concurrent motor suppression task (Experiment 2) and when the objects to be memorized were unmanipulable (Experiment 3). The motor similarity effect provides evidence for the role of motor affordances in object memory.

  6. Wind Turbine Experiments at Full Dynamic Similarity

    NASA Astrophysics Data System (ADS)

    Miller, Mark; Kiefer, Janik; Westergaard, Carsten; Hultmark, Marcus

    2015-11-01

    Performing experiments with scaled-down wind turbines has traditionally been difficult due to the matching requirements of the two driving non-dimensional parameters, the Tip Speed Ratio (TSR) and the Reynolds number. Typically, full-size turbines must be used to provide the baseline cases for engineering models and computer simulations where flow similarity is required. We present a new approach to investigating wind turbine aerodynamics at full dynamic similarity by employing a high-pressure wind tunnel at Princeton University known as the High Reynolds number Test Facility (or HRTF). This facility allows for Reynolds numbers of up to 3 million (based on chord and velocity at the tip) while still matching the TSR, on a geometrically similar, small-scale model. The background development of this project is briefly presented including the design and manufacture of a model turbine. Following this the power, thrust and wake data are discussed, in particular the scaling dependence on the Reynolds number. Supported under NSF grant CBET-1435254 (program manager Gregory Rorrer).

  7. Nonlocal similarity based DEM super resolution

    NASA Astrophysics Data System (ADS)

    Xu, Zekai; Wang, Xuewen; Chen, Zixuan; Xiong, Dongping; Ding, Mingyue; Hou, Wenguang

    2015-12-01

    This paper discusses a new topic, DEM super resolution, to improve the resolution of an original DEM based on its partial new measurements obtained with high resolution. A nonlocal algorithm is introduced to perform this task. The original DEM was first divided into overlapping patches, which were classified either as "test" or "learning" data depending on whether or not they are related to high resolution measurements. For each test patch, the similar patches in the learning dataset were identified via template matching. Finally, the high resolution DEM of the test patch was restored by the weighted sum of similar patches under the condition that the reconstruction weights were the same in different resolution cases. A key assumption of this strategy is that there are some repeated or similar modes in the original DEM, which is quite common. Experiments were done to demonstrate that we can restore a DEM by preserving the details without introducing artifacts. Statistic analysis was also conducted to show that this method can obtain higher accuracy than traditional interpolation methods.

  8. Category-based induction from similarity of neural activation.

    PubMed

    Weber, Matthew J; Osherson, Daniel

    2014-03-01

    The idea that similarity might be an engine of inductive inference dates back at least as far as David Hume. However, Hume's thesis is difficult to test without begging the question, since judgments of similarity may be infected by inferential processes. We present a one-parameter model of category-based induction that generates predictions about arbitrary statements of conditional probability over a predicate and a set of items. The prediction is based on the unconditional probabilities and similarities that characterize that predicate and those items. To test Hume's thesis, we collected brain activation from various regions of the ventral visual stream during a categorization task that did not invite comparison of categories. We then calculated the similarity of those activation patterns using a simple measure of vectorwise similarity and supplied those similarities to the model. The model's outputs correlated well with subjects' judgments of conditional probability. Our results represent a promising first step toward confirming Hume's thesis; similarity, assessed without reference to induction, may well drive inductive inference.

  9. Using today's Strategic Defense Initiative (SDI) technologies to accomplish tomorrow's low cost space missions

    NASA Astrophysics Data System (ADS)

    Farmer, Dean A.

    1992-08-01

    The various core technologies developed from the SDI programs are described and the cost and weight reductions that have resulted from the systematic exploitation of today's aerospace expertise are characterized. Avionics, sensors, and on-orbit propulsion systems can be utilized in developing small, low-cost devices for space exploration with significant performance capabilities. It is shown how the resulting core technologies can be employed in constructing three specific types of miniaturized spacecraft: a 16 kg planetary rover, a 200 kg lunar lander, and a 45 kg space vehicle repair and rescue craft.

  10. Challenges and Accomplishments. Report on Florida's Adult Education Programs. A Report for Fiscal Year 1995.

    ERIC Educational Resources Information Center

    McFadden, Liza

    This report provides an overview of the adult education in Florida, demonstrating the societal as well as individual benefits of adult education. The document highlights findings of two reports:"Results of Florida's Fourth Year Adult Education Program Evaluation" and "Adult Education Annual Performance Report." Findings include the following: (1)…

  11. Structures and Dynamics Division: Research and technology plans for FY 1983 and accomplishments for FY 1982

    NASA Technical Reports Server (NTRS)

    Bales, K. S.

    1983-01-01

    The objectives, expected results, approach, and milestones for research projects of the IPAD Project Office and the impact dynamics, structural mechanics, and structural dynamics branches of the Structures and Dynamics Division are presented. Research facilities are described. Topics covered include computer aided design; general aviation/transport crash dynamics; aircraft ground performance; composite structures; failure analysis, space vehicle dynamics; and large space structures.

  12. History and Accomplishments of USDA-ARS Avian Disease and Oncology Laboratory

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The USDA-Agricultural Research Service Avian Disease and Oncology Laboratory (ADOL) in East Lansing, Michigan, formerly known as Regional Poultry Research Laboratory, was dedicated on August 8, 1939. Its establishment was the result of joint efforts by the Agricultural Experiment Stations of the Nor...

  13. A similarity-based data warehousing environment for medical images.

    PubMed

    Teixeira, Jefferson William; Annibal, Luana Peixoto; Felipe, Joaquim Cezar; Ciferri, Ricardo Rodrigues; Ciferri, Cristina Dutra de Aguiar

    2015-11-01

    A core issue of the decision-making process in the medical field is to support the execution of analytical (OLAP) similarity queries over images in data warehousing environments. In this paper, we focus on this issue. We propose imageDWE, a non-conventional data warehousing environment that enables the storage of intrinsic features taken from medical images in a data warehouse and supports OLAP similarity queries over them. To comply with this goal, we introduce the concept of perceptual layer, which is an abstraction used to represent an image dataset according to a given feature descriptor in order to enable similarity search. Based on this concept, we propose the imageDW, an extended data warehouse with dimension tables specifically designed to support one or more perceptual layers. We also detail how to build an imageDW and how to load image data into it. Furthermore, we show how to process OLAP similarity queries composed of a conventional predicate and a similarity search predicate that encompasses the specification of one or more perceptual layers. Moreover, we introduce an index technique to improve the OLAP query processing over images. We carried out performance tests over a data warehouse environment that consolidated medical images from exams of several modalities. The results demonstrated the feasibility and efficiency of our proposed imageDWE to manage images and to process OLAP similarity queries. The results also demonstrated that the use of the proposed index technique guaranteed a great improvement in query processing.

  14. A literature-based similarity metric for biological processes

    PubMed Central

    Chagoyen, Monica; Carmona-Saez, Pedro; Gil, Concha; Carazo, Jose M; Pascual-Montano, Alberto

    2006-01-01

    Background Recent analyses in systems biology pursue the discovery of functional modules within the cell. Recognition of such modules requires the integrative analysis of genome-wide experimental data together with available functional schemes. In this line, methods to bridge the gap between the abstract definitions of cellular processes in current schemes and the interlinked nature of biological networks are required. Results This work explores the use of the scientific literature to establish potential relationships among cellular processes. To this end we haveused a document based similarity method to compute pair-wise similarities of the biological processes described in the Gene Ontology (GO). The method has been applied to the biological processes annotated for the Saccharomyces cerevisiae genome. We compared our results with similarities obtained with two ontology-based metrics, as well as with gene product annotation relationships. We show that the literature-based metric conserves most direct ontological relationships, while reveals biologically sounded similarities that are not obtained using ontology-based metrics and/or genome annotation. Conclusion The scientific literature is a valuable source of information from which to compute similarities among biological processes. The associations discovered by literature analysis are a valuable complement to those encoded in existing functional schemes, and those that arise by genome annotation. These similarities can be used to conveniently map the interlinked structure of cellular processes in a particular organism. PMID:16872502

  15. A similarity-based data warehousing environment for medical images.

    PubMed

    Teixeira, Jefferson William; Annibal, Luana Peixoto; Felipe, Joaquim Cezar; Ciferri, Ricardo Rodrigues; Ciferri, Cristina Dutra de Aguiar

    2015-11-01

    A core issue of the decision-making process in the medical field is to support the execution of analytical (OLAP) similarity queries over images in data warehousing environments. In this paper, we focus on this issue. We propose imageDWE, a non-conventional data warehousing environment that enables the storage of intrinsic features taken from medical images in a data warehouse and supports OLAP similarity queries over them. To comply with this goal, we introduce the concept of perceptual layer, which is an abstraction used to represent an image dataset according to a given feature descriptor in order to enable similarity search. Based on this concept, we propose the imageDW, an extended data warehouse with dimension tables specifically designed to support one or more perceptual layers. We also detail how to build an imageDW and how to load image data into it. Furthermore, we show how to process OLAP similarity queries composed of a conventional predicate and a similarity search predicate that encompasses the specification of one or more perceptual layers. Moreover, we introduce an index technique to improve the OLAP query processing over images. We carried out performance tests over a data warehouse environment that consolidated medical images from exams of several modalities. The results demonstrated the feasibility and efficiency of our proposed imageDWE to manage images and to process OLAP similarity queries. The results also demonstrated that the use of the proposed index technique guaranteed a great improvement in query processing. PMID:26414378

  16. Similarity-Based Classification in Partially Labeled Networks

    NASA Astrophysics Data System (ADS)

    Zhang, Qian-Ming; Shang, Ming-Sheng; Lü, Linyuan

    Two main difficulties in the problem of classification in partially labeled networks are the sparsity of the known labeled nodes and inconsistency of label information. To address these two difficulties, we propose a similarity-based method, where the basic assumption is that two nodes are more likely to be categorized into the same class if they are more similar. In this paper, we introduce ten similarity indices defined based on the network structure. Empirical results on the co-purchase network of political books show that the similarity-based method can, to some extent, overcome these two difficulties and give higher accurate classification than the relational neighbors method, especially when the labeled nodes are sparse. Furthermore, we find that when the information of known labeled nodes is sufficient, the indices considering only local information can perform as good as those global indices while having much lower computational complexity.

  17. Similarity-Based Modeling Applied to Signal Detection in Pharmacovigilance

    PubMed Central

    Vilar, S; Ryan, P B; Madigan, D; Stang, P E; Schuemie, M J; Friedman, C; Tatonetti, N P; Hripcsak, G

    2014-01-01

    One of the main objectives in pharmacovigilance is the detection of adverse drug events (ADEs) through mining of healthcare databases, such as electronic health records or administrative claims data. Although different approaches have been shown to be of great value, research is still focusing on the enhancement of signal detection to gain efficiency in further assessment and follow-up. We applied similarity-based modeling techniques, using 2D and 3D molecular structure, ADE, target, and ATC (anatomical therapeutic chemical) similarity measures, to the candidate associations selected previously in a medication-wide association study for four ADE outcomes. Our results showed an improvement in the precision when we ranked the subset of ADE candidates using similarity scorings. This method is simple, useful to strengthen or prioritize signals generated from healthcare databases, and facilitates ADE detection through the identification of the most similar drugs for which ADE information is available. PMID:25250527

  18. Musical structure analysis using similarity matrix and dynamic programming

    NASA Astrophysics Data System (ADS)

    Shiu, Yu; Jeong, Hong; Kuo, C.-C. Jay

    2005-10-01

    Automatic music segmentation and structure analysis from audio waveforms based on a three-level hierarchy is examined in this research, where the three-level hierarchy includes notes, measures and parts. The pitch class profile (PCP) feature is first extracted at the note level. Then, a similarity matrix is constructed at the measure level, where a dynamic time warping (DTW) technique is used to enhance the similarity computation by taking the temporal distortion of similar audio segments into account. By processing the similarity matrix, we can obtain a coarse-grain music segmentation result. Finally, dynamic programming is applied to the coarse-grain segments so that a song can be decomposed into several major parts such as intro, verse, chorus, bridge and outro. The performance of the proposed music structure analysis system is demonstrated for pop and rock music.

  19. [Publication of an original work: for self accomplishment as well as for advancement of medicine].

    PubMed

    Isono, Shiroh

    2015-01-01

    Medical researchers are expected to give back their study results to society (the patient). In this context conference presentation and publication in a scientific journal are the final stages for the purpose. Therefore, the researchers should have knowledge and skill on how to present and write the results logically, readably and attractively as a scientific original manuscript Scientific misconduct such as fabrication and plagiarism blocks advance of the field and deserve social and criminal sanction. Reviewers of the manuscript place a high value of novelty of the research and its clinical and scientific impact in addition to accuracy and reproducibility of the methodology of the study. They provide constructive suggestions for improving it as experts of the field. The authors should read their comments carefully and communicate with them effectively. Young anesthesiologists are encouraged to experience a sense of achievement of publication of their original work. PMID:25868202

  20. [Publication of an original work: for self accomplishment as well as for advancement of medicine].

    PubMed

    Isono, Shiroh

    2015-01-01

    Medical researchers are expected to give back their study results to society (the patient). In this context conference presentation and publication in a scientific journal are the final stages for the purpose. Therefore, the researchers should have knowledge and skill on how to present and write the results logically, readably and attractively as a scientific original manuscript Scientific misconduct such as fabrication and plagiarism blocks advance of the field and deserve social and criminal sanction. Reviewers of the manuscript place a high value of novelty of the research and its clinical and scientific impact in addition to accuracy and reproducibility of the methodology of the study. They provide constructive suggestions for improving it as experts of the field. The authors should read their comments carefully and communicate with them effectively. Young anesthesiologists are encouraged to experience a sense of achievement of publication of their original work.