Science.gov

Sample records for accurate cost information

  1. The high cost of accurate knowledge.

    PubMed

    Sutcliffe, Kathleen M; Weber, Klaus

    2003-05-01

    Many business thinkers believe it's the role of senior managers to scan the external environment to monitor contingencies and constraints, and to use that precise knowledge to modify the company's strategy and design. As these thinkers see it, managers need accurate and abundant information to carry out that role. According to that logic, it makes sense to invest heavily in systems for collecting and organizing competitive information. Another school of pundits contends that, since today's complex information often isn't precise anyway, it's not worth going overboard with such investments. In other words, it's not the accuracy and abundance of information that should matter most to top executives--rather, it's how that information is interpreted. After all, the role of senior managers isn't just to make decisions; it's to set direction and motivate others in the face of ambiguities and conflicting demands. Top executives must interpret information and communicate those interpretations--they must manage meaning more than they must manage information. So which of these competing views is the right one? Research conducted by academics Sutcliffe and Weber found that how accurate senior executives are about their competitive environments is indeed less important for strategy and corresponding organizational changes than the way in which they interpret information about their environments. Investments in shaping those interpretations, therefore, may create a more durable competitive advantage than investments in obtaining and organizing more information. And what kinds of interpretations are most closely linked with high performance? Their research suggests that high performers respond positively to opportunities, yet they aren't overconfident in their abilities to take advantage of those opportunities. PMID:12747164

  2. The thermodynamic cost of accurate sensory adaptation

    NASA Astrophysics Data System (ADS)

    Tu, Yuhai

    2015-03-01

    Living organisms need to obtain and process environment information accurately in order to make decisions critical for their survival. Much progress have been made in identifying key components responsible for various biological functions, however, major challenges remain to understand system-level behaviors from the molecular-level knowledge of biology and to unravel possible physical principles for the underlying biochemical circuits. In this talk, we will present some recent works in understanding the chemical sensory system of E. coli by combining theoretical approaches with quantitative experiments. We focus on addressing the questions on how cells process chemical information and adapt to varying environment, and what are the thermodynamic limits of key regulatory functions, such as adaptation.

  3. You Can Accurately Predict Land Acquisition Costs.

    ERIC Educational Resources Information Center

    Garrigan, Richard

    1967-01-01

    Land acquisition costs were tested for predictability based upon the 1962 assessed valuations of privately held land acquired for campus expansion by the University of Wisconsin from 1963-1965. By correlating the land acquisition costs of 108 properties acquired during the 3 year period with--(1) the assessed value of the land, (2) the assessed…

  4. Managing Information On Costs

    NASA Technical Reports Server (NTRS)

    Taulbee, Zoe A.

    1990-01-01

    Cost Management Model, CMM, software tool for planning, tracking, and reporting costs and information related to costs. Capable of estimating costs, comparing estimated to actual costs, performing "what-if" analyses on estimates of costs, and providing mechanism to maintain data on costs in format oriented to management. Number of supportive cost methods built in: escalation rates, production-learning curves, activity/event schedules, unit production schedules, set of spread distributions, tables of rates and factors defined by user, and full arithmetic capability. Import/export capability possible with 20/20 Spreadsheet available on Data General equipment. Program requires AOS/VS operating system available on Data General MV series computers. Written mainly in FORTRAN 77 but uses SGU (Screen Generation Utility).

  5. Accurate, low-cost 3D-models of gullies

    NASA Astrophysics Data System (ADS)

    Onnen, Nils; Gronz, Oliver; Ries, Johannes B.; Brings, Christine

    2015-04-01

    are able to produce accurate and low-cost 3D-models of gullies.

  6. Approaching system equilibrium with accurate or not accurate feedback information in a two-route system

    NASA Astrophysics Data System (ADS)

    Zhao, Xiao-mei; Xie, Dong-fan; Li, Qi

    2015-02-01

    With the development of intelligent transport system, advanced information feedback strategies have been developed to reduce traffic congestion and enhance the capacity. However, previous strategies provide accurate information to travelers and our simulation results show that accurate information brings negative effects, especially in delay case. Because travelers prefer to the best condition route with accurate information, and delayed information cannot reflect current traffic condition but past. Then travelers make wrong routing decisions, causing the decrease of the capacity and the increase of oscillations and the system deviating from the equilibrium. To avoid the negative effect, bounded rationality is taken into account by introducing a boundedly rational threshold BR. When difference between two routes is less than the BR, routes have equal probability to be chosen. The bounded rationality is helpful to improve the efficiency in terms of capacity, oscillation and the gap deviating from the system equilibrium.

  7. 78 FR 34604 - Submitting Complete and Accurate Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... COMMISSION 10 CFR Part 50 Submitting Complete and Accurate Information AGENCY: Nuclear Regulatory Commission... accurate information as would a licensee or an applicant for a license.'' DATES: Submit comments by August... may submit comments by any of the following methods (unless this document describes a different...

  8. Accurate charge capture and cost allocation: cost justification for bedside computing.

    PubMed Central

    Grewal, R.; Reed, R. L.

    1993-01-01

    This paper shows that cost justification for bedside clinical computing can be made by recouping charges with accurate charge capture. Twelve months worth of professional charges for a sixteen bed surgical intensive care unit are computed from charted data in a bedside clinical database and are compared to the professional charges actually billed by the unit. A substantial difference in predicted charges and billed charges was found. This paper also discusses the concept of appropriate cost allocation in the inpatient environment and the feasibility of appropriate allocation as a by-product of bedside computing. PMID:8130444

  9. The free energy cost of accurate biochemical oscillations

    PubMed Central

    Cao, Yuansheng; Wang, Hongli; Ouyang, Qi; Tu, Yuhai

    2015-01-01

    Oscillation is an important cellular process that regulates timing of different vital life cycles. However, in the noisy cellular environment, oscillations can be highly inaccurate due to phase fluctuations. It remains poorly understood how biochemical circuits suppress phase fluctuations and what is the incurred thermodynamic cost. Here, we study three different types of biochemical oscillations representing three basic oscillation motifs shared by all known oscillatory systems. In all the systems studied, we find that the phase diffusion constant depends on the free energy dissipation per period following the same inverse relation parameterized by system specific constants. This relationship and its range of validity are shown analytically in a model of noisy oscillation. Microscopically, we find that the oscillation is driven by multiple irreversible cycles that hydrolyze the fuel molecules such as ATP; the number of phase coherent periods is proportional to the free energy consumed per period. Experimental evidence in support of this general relationship and testable predictions are also presented. PMID:26566392

  10. 77 FR 11191 - Insurance Cost Information Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ..., 58 FR 12545, NHTSA amended 49 CFR part 582, Insurance Cost Information Regulation, to require all... National Highway Traffic Safety Administration Insurance Cost Information Regulation AGENCY: National... insurance cost information booklet that all car dealers must make available to prospective...

  11. The Costs of Free Information.

    ERIC Educational Resources Information Center

    Guida, Richard A.

    1989-01-01

    Although the goal of the Freedom of Information Act (FOIA) is to make government more open and accountable, a number of unintended effects have resulted. Amendments are proposed to prevent the use of the FOIA by criminals and foreign agents and to place the cost of administering the law on the user. (FMW)

  12. Ultra-accurate collaborative information filtering via directed user similarity

    NASA Astrophysics Data System (ADS)

    Guo, Q.; Song, W.-J.; Liu, J.-G.

    2014-07-01

    A key challenge of the collaborative filtering (CF) information filtering is how to obtain the reliable and accurate results with the help of peers' recommendation. Since the similarities from small-degree users to large-degree users would be larger than the ones in opposite direction, the large-degree users' selections are recommended extensively by the traditional second-order CF algorithms. By considering the users' similarity direction and the second-order correlations to depress the influence of mainstream preferences, we present the directed second-order CF (HDCF) algorithm specifically to address the challenge of accuracy and diversity of the CF algorithm. The numerical results for two benchmark data sets, MovieLens and Netflix, show that the accuracy of the new algorithm outperforms the state-of-the-art CF algorithms. Comparing with the CF algorithm based on random walks proposed by Liu et al. (Int. J. Mod. Phys. C, 20 (2009) 285) the average ranking score could reach 0.0767 and 0.0402, which is enhanced by 27.3% and 19.1% for MovieLens and Netflix, respectively. In addition, the diversity, precision and recall are also enhanced greatly. Without relying on any context-specific information, tuning the similarity direction of CF algorithms could obtain accurate and diverse recommendations. This work suggests that the user similarity direction is an important factor to improve the personalized recommendation performance.

  13. The cost of a hospital ward in Europe: is there a methodology available to accurately measure the costs?

    PubMed

    Negrini, D; Kettle, A; Sheppard, L; Mills, G H; Edbrooke, D L

    2004-01-01

    Costing health care services has become a major requirement due to an increase in demand for health care and technological advances. Several studies have been published describing the computation of the costs of hospital wards. The objective of this article is to examine the methodologies utilised to try to describe the basic components of a standardised method, which could be applied throughout Europe. Cost measurement however is a complex matter and a lack of clarity exists in the terminology and the cost concepts utilised. The methods discussed in this review make it evident that there is a lack of standardized methodologies for the determination of accurate costs of hospital wards. A standardized costing methodology would facilitate comparisons, encourage economic evaluation within the ward and hence assist in the decision-making process with regard to the efficient allocation of resources. PMID:15366283

  14. 76 FR 6516 - Insurance Cost Information Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... Vehicle Information and Cost Savings Act, 15 U.S.C. 1941(e), on March 5, 1993, 58 FR 12545, the National... National Highway Traffic Safety Administration Insurance Cost Information Regulation AGENCY: National... announces publication by NHTSA of the 2011 text and data for the annual insurance cost information...

  15. 75 FR 5169 - Insurance Cost Information Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... Vehicle Information and Cost Savings Act, 15 U.S.C. 1941(e), on March 5, 1993, 58 FR 12545, the National... National Highway Traffic Safety Administration Insurance Cost Information Regulation AGENCY: National... announces publication by NHTSA of the 2008 text and data for the annual insurance cost information...

  16. Cost Information and Formula Funding: New Approaches.

    ERIC Educational Resources Information Center

    Allen, Richard H., Ed.; Topping, James R., Ed.

    A report based on a conference on the impact of cost information on statewide budgeting and planning is presented. The conference was organized around case-study reports on the use of cost information in higher education budgeting in Florida, Indiana, Washington, and Wisconsin. Rather than publishing convention proceedings, the case studies were…

  17. Rationalizing Management Information System Costs.

    ERIC Educational Resources Information Center

    Parden, Robert J.

    This paper examines the proposition that management information systems (MIS) for colleges and universities are not achieving their original objectives of supporting better management decisions by providing more and better information in a more timely manner. As a consequence, the MIS activity should be reduced in scope, and standardized to…

  18. A new accurate pill recognition system using imprint information

    NASA Astrophysics Data System (ADS)

    Chen, Zhiyuan; Kamata, Sei-ichiro

    2013-12-01

    Great achievements in modern medicine benefit human beings. Also, it has brought about an explosive growth of pharmaceuticals that current in the market. In daily life, pharmaceuticals sometimes confuse people when they are found unlabeled. In this paper, we propose an automatic pill recognition technique to solve this problem. It functions mainly based on the imprint feature of the pills, which is extracted by proposed MSWT (modified stroke width transform) and described by WSC (weighted shape context). Experiments show that our proposed pill recognition method can reach an accurate rate up to 92.03% within top 5 ranks when trying to classify more than 10 thousand query pill images into around 2000 categories.

  19. Indirect Costs of University Research: Background Information.

    ERIC Educational Resources Information Center

    Voet, Tony Vander

    This paper is intended to provide a solid base of information about the treatment of indirect university research costs in various jurisdictions and to highlight some of the factors that have contributed to increased interest in the issues surrounding the funding of indirect costs of research. University research in Ontario has continued to evolve…

  20. The Good, the Strong, and the Accurate: Preschoolers' Evaluations of Informant Attributes

    ERIC Educational Resources Information Center

    Fusaro, Maria; Corriveau, Kathleen H.; Harris, Paul L.

    2011-01-01

    Much recent evidence shows that preschoolers are sensitive to the accuracy of an informant. Faced with two informants, one of whom names familiar objects accurately and the other inaccurately, preschoolers subsequently prefer to learn the names and functions of unfamiliar objects from the more accurate informant. This study examined the inference…

  1. Transaction costs, externalities and information technology in health care.

    PubMed

    Ferguson, B; Keen, J

    1996-01-01

    This paper discusses some of the economic issues which underpin the rationale for investment in information and communications technologies (ICTs). Information imperfections lead to significant transaction costs (search, negotiating and monitoring) which in turn confer a negative externality on parties involved in exchange. This divergence in private and social costs leads to a degree of resource misallocation (efficiency loss) which, uncorrected, results in a sub-optimal outcome. Traditional solutions to this problem are to rely upon direct government action to reduce the costs of transacting between market agents, or to employ tax/subsidy measures and other legislative action to achieve the desired market outcome. Three key policy questions are raised in the context of the NHS purchaser/provider relationship. Firstly, what is the optimum level of transaction costs; secondly, can ICTs assist in lowering the level of transaction costs to the optimum level; thirdly, who should bear the investment cost in reducing the level of transaction costs? The issue of property rights in different information systems is discussed and raises interesting policy questions about how much investment should be undertaken centrally rather than devolved to a more local level. In some ways this economic framework offers a post hoc justification of why different ICT systems have been introduced at various levels of the NHS. Essentially this reduces to the problem of externalities: providing good information confers a positive externality: not providing relevant, timely and accurate information confers a negative externality, by increasing further the level of transaction costs. The crucial role which ICT systems can play lies in attempting to reduce the level of transaction costs and driving the market towards what Dahlman has described as the transaction-cost-constrained equilibrium. PMID:8653190

  2. Measuring nonlinear oscillations using a very accurate and low-cost linear optical position transducer

    NASA Astrophysics Data System (ADS)

    Donoso, Guillermo; Ladera, Celso L.

    2016-09-01

    An accurate linear optical displacement transducer of about 0.2 mm resolution over a range of ∼40 mm is presented. This device consists of a stack of thin cellulose acetate strips, each strip longitudinally slid ∼0.5 mm over the precedent one so that one end of the stack becomes a stepped wedge of constant step. A narrowed light beam from a white LED orthogonally incident crosses the wedge at a known point, the transmitted intensity being detected with a phototransistor whose emitter is connected to a diode. We present the interesting analytical proof that the voltage across the diode is linearly dependent upon the ordinate of the point where the light beam falls on the wedge, as well as the experimental validation of such a theoretical proof. Applications to nonlinear oscillations are then presented—including the interesting case of a body moving under dry friction, and the more advanced case of an oscillator in a quartic energy potential—whose time-varying positions were accurately measured with our transducer. Our sensing device can resolve the dynamics of an object attached to it with great accuracy and precision at a cost considerably less than that of a linear neutral density wedge. The technique used to assemble the wedge of acetate strips is described.

  3. Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment

    PubMed Central

    2011-01-01

    Background Despite the availability of effective therapies, asthma remains a source of significant morbidity and use of health care resources. The central research question of the ACCURATE trial is whether maximal doses of (combination) therapy should be used for long periods in an attempt to achieve complete control of all features of asthma. An additional question is whether patients and society value the potential incremental benefit, if any, sufficiently to concur with such a treatment approach. We assessed patient preferences and cost-effectiveness of three treatment strategies aimed at achieving different levels of clinical control: 1. sufficiently controlled asthma 2. strictly controlled asthma 3. strictly controlled asthma based on exhaled nitric oxide as an additional disease marker Design 720 Patients with mild to moderate persistent asthma from general practices with a practice nurse, age 18-50 yr, daily treatment with inhaled corticosteroids (more then 3 months usage of inhaled corticosteroids in the previous year), will be identified via patient registries of general practices in the Leiden, Nijmegen, and Amsterdam areas in The Netherlands. The design is a 12-month cluster-randomised parallel trial with 40 general practices in each of the three arms. The patients will visit the general practice at baseline, 3, 6, 9, and 12 months. At each planned and unplanned visit to the general practice treatment will be adjusted with support of an internet-based asthma monitoring system supervised by a central coordinating specialist nurse. Patient preferences and utilities will be assessed by questionnaire and interview. Data on asthma control, treatment step, adherence to treatment, utilities and costs will be obtained every 3 months and at each unplanned visit. Differences in societal costs (medication, other (health) care and productivity) will be compared to differences in the number of limited activity days and in quality adjusted life years (Dutch EQ5D, SF6D

  4. 78 FR 71558 - Insurance Cost Information Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... April 11, 2000 (65 FR 19477-78). For access to the docket to read background documents or comments... History B. Public Law 112-252 C. Insurance Cost Information Booklet II. Comments Requested III. Requests.../Legislative History In response to a growing concern about the large amount of money the American consumer...

  5. A Low Cost Course Information Syndication System

    ERIC Educational Resources Information Center

    Ajayi, A. O.; Olajubu, E. A.; Bello, S. A.; Soriyan, H. A.; Obamuyide, A. V.

    2011-01-01

    This study presents a cost effective, reliable, and convenient mobile web-based system to facilitate the dissemination of course information to students, to support interaction that goes beyond the classroom. The system employed the Really Simple Syndication (RSS) technology and was developed using Rapid Application Development (RAD) methodology.…

  6. A Low-Cost Modular Platform for Heterogeneous Data Acquisition with Accurate Interchannel Synchronization

    PubMed Central

    Blanco-Claraco, José Luis; López-Martínez, Javier; Torres-Moreno, José Luis; Giménez-Fernández, Antonio

    2015-01-01

    Most experimental fields of science and engineering require the use of data acquisition systems (DAQ), devices in charge of sampling and converting electrical signals into digital data and, typically, performing all of the required signal preconditioning. Since commercial DAQ systems are normally focused on specific types of sensors and actuators, systems engineers may need to employ mutually-incompatible hardware from different manufacturers in applications demanding heterogeneous inputs and outputs, such as small-signal analog inputs, differential quadrature rotatory encoders or variable current outputs. A common undesirable side effect of heterogeneous DAQ hardware is the lack of an accurate synchronization between samples captured by each device. To solve such a problem with low-cost hardware, we present a novel modular DAQ architecture comprising a base board and a set of interchangeable modules. Our main design goal is the ability to sample all sources at predictable, fixed sampling frequencies, with a reduced synchronization mismatch (<1 μs) between heterogeneous signal sources. We present experiments in the field of mechanical engineering, illustrating vibration spectrum analyses from piezoelectric accelerometers and, as a novelty in these kinds of experiments, the spectrum of quadrature encoder signals. Part of the design and software will be publicly released online. PMID:26516865

  7. A Low-Cost Modular Platform for Heterogeneous Data Acquisition with Accurate Interchannel Synchronization.

    PubMed

    Blanco-Claraco, José Luis; López-Martínez, Javier; Torres-Moreno, José Luis; Giménez-Fernández, Antonio

    2015-01-01

    Most experimental fields of science and engineering require the use of data acquisition systems (DAQ), devices in charge of sampling and converting electrical signals into digital data and, typically, performing all of the required signal preconditioning. Since commercial DAQ systems are normally focused on specific types of sensors and actuators, systems engineers may need to employ mutually-incompatible hardware from different manufacturers in applications demanding heterogeneous inputs and outputs, such as small-signal analog inputs, differential quadrature rotatory encoders or variable current outputs. A common undesirable side effect of heterogeneous DAQ hardware is the lack of an accurate synchronization between samples captured by each device. To solve such a problem with low-cost hardware, we present a novel modular DAQ architecture comprising a base board and a set of interchangeable modules. Our main design goal is the ability to sample all sources at predictable, fixed sampling frequencies, with a reduced synchronization mismatch (<1 µs) between heterogeneous signal sources. We present experiments in the field of mechanical engineering, illustrating vibration spectrum analyses from piezoelectric accelerometers and, as a novelty in these kinds of experiments, the spectrum of quadrature encoder signals. Part of the design and software will be publicly released online. PMID:26516865

  8. Modelling the Constraints of Spatial Environment in Fauna Movement Simulations: Comparison of a Boundaries Accurate Function and a Cost Function

    NASA Astrophysics Data System (ADS)

    Jolivet, L.; Cohen, M.; Ruas, A.

    2015-08-01

    Landscape influences fauna movement at different levels, from habitat selection to choices of movements' direction. Our goal is to provide a development frame in order to test simulation functions for animal's movement. We describe our approach for such simulations and we compare two types of functions to calculate trajectories. To do so, we first modelled the role of landscape elements to differentiate between elements that facilitate movements and the ones being hindrances. Different influences are identified depending on landscape elements and on animal species. Knowledge were gathered from ecologists, literature and observation datasets. Second, we analysed the description of animal movement recorded with GPS at fine scale, corresponding to high temporal frequency and good location accuracy. Analysing this type of data provides information on the relation between landscape features and movements. We implemented an agent-based simulation approach to calculate potential trajectories constrained by the spatial environment and individual's behaviour. We tested two functions that consider space differently: one function takes into account the geometry and the types of landscape elements and one cost function sums up the spatial surroundings of an individual. Results highlight the fact that the cost function exaggerates the distances travelled by an individual and simplifies movement patterns. The geometry accurate function represents a good bottom-up approach for discovering interesting areas or obstacles for movements.

  9. Waste Management Facilities Cost Information Report

    SciTech Connect

    Feizollahi, F.; Shropshire, D.

    1992-10-01

    The Waste Management Facility Cost Information (WMFCI) Report, commissioned by the US Department of Energy (DOE), develops planning life-cycle cost (PLCC) estimates for treatment, storage, and disposal facilities. This report contains PLCC estimates versus capacity for 26 different facility cost modules. A procedure to guide DOE and its contractor personnel in the use of estimating data is also provided. Estimates in the report apply to five distinctive waste streams: low-level waste, low-level mixed waste, alpha contaminated low-level waste, alpha contaminated low-level mixed waste, and transuranic waste. The report addresses five different treatment types: incineration, metal/melting and recovery, shredder/compaction, solidification, and vitrification. Data in this report allows the user to develop PLCC estimates for various waste management options.

  10. Accurate and cost-effective natural resource data from super large scale aerial photography

    NASA Astrophysics Data System (ADS)

    Grotefendt, Richard Alan

    Increasing amounts and types of timely and accurate data are required for monitoring to ensure compliance with natural resource regulatory requirements. This study developed a cost-effective method to partially fulfill these data requirements using super large scale aerial photography (Scale: greater than 1:2,000). Two synchronized, metric, Rolleiflex 70mm (2.76in) cameras mounted 12m (40ft) apart on a rigid platform and carried at 5.6 km/hr (3 knots) by a helicopter collected this high resolution, 3D imagery from Alaska and Washington. The overlapping photo pairs provided 3D views of natural resource objects as fine as twigs. The 12m (40ft) inter-camera distance improved ground visibility between tree crowns of dense old growth forests. Analytical stereoplotters and the application of photogrammetric principles enabled measurement and interpretation of photo objects such as trees and their height in a cost-effective way. Horizontal and vertical measurement accuracy was within 2% and 3% of field measurement, respectively. Forest inventory and riparian buffer monitoring applications were used to test this method. Although field work is still required to develop photo-field relationships unique to each ecosystem and for quality assurance, the photo estimates of individual tree height, volume, diameter, type, and location, as well as down tree decay class and landing spot, plot timber volume, and area were comparable to and may replace approximately 95% of field effort. For example, the average of the absolute differences between field and photo estimates for tree height was 2.4m (7.8ft) (s.d. = 2.1m (6.8ft), n = 376), diameter at breast height (1.4m (4.5ft) above ground on uphill tree side) was 5.8cm (2.3in) (s.d. = 5.6cm (2.2in), n = 109), and plot volume in gross board feet was within 10.9% to 13.4% (n = 10) depending on the estimator used. Forest type was correctly classified 99.4% (n = 180) of the time. Timber inventory, species identification, sample

  11. The minimal work cost of information processing.

    PubMed

    Faist, Philippe; Dupuis, Frédéric; Oppenheim, Jonathan; Renner, Renato

    2015-01-01

    Irreversible information processing cannot be carried out without some inevitable thermodynamical work cost. This fundamental restriction, known as Landauer's principle, is increasingly relevant today, as the energy dissipation of computing devices impedes the development of their performance. Here we determine the minimal work required to carry out any logical process, for instance a computation. It is given by the entropy of the discarded information conditional to the output of the computation. Our formula takes precisely into account the statistically fluctuating work requirement of the logical process. It enables the explicit calculation of practical scenarios, such as computational circuits or quantum measurements. On the conceptual level, our result gives a precise and operational connection between thermodynamic and information entropy, and explains the emergence of the entropy state function in macroscopic thermodynamics. PMID:26151678

  12. The minimal work cost of information processing

    PubMed Central

    Faist, Philippe; Dupuis, Frédéric; Oppenheim, Jonathan; Renner, Renato

    2015-01-01

    Irreversible information processing cannot be carried out without some inevitable thermodynamical work cost. This fundamental restriction, known as Landauer's principle, is increasingly relevant today, as the energy dissipation of computing devices impedes the development of their performance. Here we determine the minimal work required to carry out any logical process, for instance a computation. It is given by the entropy of the discarded information conditional to the output of the computation. Our formula takes precisely into account the statistically fluctuating work requirement of the logical process. It enables the explicit calculation of practical scenarios, such as computational circuits or quantum measurements. On the conceptual level, our result gives a precise and operational connection between thermodynamic and information entropy, and explains the emergence of the entropy state function in macroscopic thermodynamics. PMID:26151678

  13. 16 CFR 1101.32 - Reasonable steps to assure information is accurate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Reasonable Steps Commission Will Take To Assure Information It Discloses Is Accurate, and That Disclosure Is..., injuries or safety-related incidents involving such a product. Such persons would include, for example, a... set forth below are the steps the Commission will take to analyze the accuracy of information which...

  14. 16 CFR 1101.32 - Reasonable steps to assure information is accurate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Reasonable Steps Commission Will Take To Assure Information It Discloses Is Accurate, and That Disclosure Is..., injuries or safety-related incidents involving such a product. Such persons would include, for example, a... set forth below are the steps the Commission will take to analyze the accuracy of information which...

  15. 16 CFR 1101.32 - Reasonable steps to assure information is accurate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Reasonable Steps Commission Will Take To Assure Information It Discloses Is Accurate, and That Disclosure Is..., injuries or safety-related incidents involving such a product. Such persons would include, for example, a... set forth below are the steps the Commission will take to analyze the accuracy of information which...

  16. 16 CFR 1101.32 - Reasonable steps to assure information is accurate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Reasonable Steps Commission Will Take To Assure Information It Discloses Is Accurate, and That Disclosure Is..., injuries or safety-related incidents involving such a product. Such persons would include, for example, a... set forth below are the steps the Commission will take to analyze the accuracy of information which...

  17. 16 CFR 1101.32 - Reasonable steps to assure information is accurate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Reasonable steps to assure information is accurate. 1101.32 Section 1101.32 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Reasonable Steps Commission Will Take...

  18. 48 CFR 1615.406-2 - Certificate of accurate cost or pricing data for community-rated carriers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Certificate of accurate cost or pricing data for community-rated carriers. 1615.406-2 Section 1615.406-2 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION...

  19. Fast Conceptual Cost Estimating of Aerospace Projects Using Historical Information

    NASA Technical Reports Server (NTRS)

    Butts, Glenn

    2007-01-01

    Accurate estimates can be created in less than a minute by applying powerful techniques and algorithms to create an Excel-based parametric cost model. In five easy steps you will learn how to normalize your company 's historical cost data to the new project parameters. This paper provides a complete, easy-to-understand, step by step how-to guide. Such a guide does not seem to currently exist. Over 2,000 hours of research, data collection, and trial and error, and thousands of lines of Excel Visual Basic Application (VBA) code were invested in developing these methods. While VBA is not required to use this information, it increases the power and aesthetics of the model. Implementing all of the steps described, while not required, will increase the accuracy of the results.

  20. Verify by Genability - Providing Solar Customers with Accurate Reports of Utility Bill Cost Savings

    SciTech Connect

    2015-12-01

    The National Renewable Energy Laboratory (NREL), partnering with Genability and supported by the U.S. Department of Energy's SunShot Incubator program, independently verified the accuracy of Genability's monthly cost savings.

  1. Controlling information technology costs, Part 2.

    PubMed

    Honan, Tom; Ciotti, Vince

    2002-01-01

    Health care executives are increasingly frustrated by Information Technology (IT). Although our industry is often accused of underinvesting in technology (hospitals average 2-3 percent of their costs in IT, compared to other industry's 8-10 percent), when IT investments are made, they fail to reflect demonstrable return to the bottom line. Yet the effective deployment of technology is so critical to the success of the organization and can in itself cause the failure of a health care system. While being forced to invest significant amounts of resources in the past two years preparing for Y2K, health care organizations have come under increasing financial pressures due to other industry developments. PMID:11968991

  2. 75 FR 57284 - Agency Information Collection Activities: Cost Submission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Cost Submission... other Federal agencies to comment on an information collection requirement concerning: Cost Submission... forms of information technology; and (e) the annual costs burden to respondents or record keepers...

  3. Species Distribution 2.0: An Accurate Time- and Cost-Effective Method of Prospection Using Street View Imagery

    PubMed Central

    Schwoertzig, Eugénie; Millon, Alexandre

    2016-01-01

    Species occurrence data provide crucial information for biodiversity studies in the current context of global environmental changes. Such studies often rely on a limited number of occurrence data collected in the field and on pseudo-absences arbitrarily chosen within the study area, which reduces the value of these studies. To overcome this issue, we propose an alternative method of prospection using geo-located street view imagery (SVI). Following a standardised protocol of virtual prospection using both vertical (aerial photographs) and horizontal (SVI) perceptions, we have surveyed 1097 randomly selected cells across Spain (0.1x0.1 degree, i.e. 20% of Spain) for the presence of Arundo donax L. (Poaceae). In total we have detected A. donax in 345 cells, thus substantially expanding beyond the now two-centuries-old field-derived record, which described A. donax only 216 cells. Among the field occurrence cells, 81.1% were confirmed by SVI prospection to be consistent with species presence. In addition, we recorded, by SVI prospection, 752 absences, i.e. cells where A. donax was considered absent. We have also compared the outcomes of climatic niche modeling based on SVI data against those based on field data. Using generalized linear models fitted with bioclimatic predictors, we have found SVI data to provide far more compelling results in terms of niche modeling than does field data as classically used in SDM. This original, cost- and time-effective method provides the means to accurately locate highly visible taxa, reinforce absence data, and predict species distribution without long and expensive in situ prospection. At this time, the majority of available SVI data is restricted to human-disturbed environments that have road networks. However, SVI is becoming increasingly available in natural areas, which means the technique has considerable potential to become an important factor in future biodiversity studies. PMID:26751565

  4. Cost-effective accurate coarse-grid method for highly convective multidimensional unsteady flows

    NASA Technical Reports Server (NTRS)

    Leonard, B. P.; Niknafs, H. S.

    1991-01-01

    A fundamentally multidimensional convection scheme is described based on vector transient interpolation modeling rewritten in conservative control-volume form. Vector third-order upwinding is used as the basis of the algorithm; this automatically introduces important cross-difference terms that are absent from schemes using component-wise one-dimensional formulas. Third-order phase accuracy is good; this is important for coarse-grid large-eddy or full simulation. Potential overshoots or undershoots are avoided by using a recently developed universal limiter. Higher order accuracy is obtained locally, where needed, by the cost-effective strategy of adaptive stencil expansion in a direction normal to each control-volume face; this is controlled by monitoring the absolute normal gradient and curvature across the face. Higher (than third) order cross-terms do not appear to be needed. Since the wider stencil is used only in isolated narrow regions (near discontinuities), extremely high (in this case, seventh) order accuracy can be achieved for little more than the cost of a globally third-order scheme.

  5. Evaluation of a low-cost and accurate ocean temperature logger on subsurface mooring systems

    SciTech Connect

    Tian, Chuan; Deng, Zhiqun; Lu, Jun; Xu, Xiaoyang; Zhao, Wei; Xu, Ming

    2014-06-23

    Monitoring seawater temperature is important to understanding evolving ocean processes. To monitor internal waves or ocean mixing, a large number of temperature loggers are typically mounted on subsurface mooring systems to obtain high-resolution temperature data at different water depths. In this study, we redesigned and evaluated a compact, low-cost, self-contained, high-resolution and high-accuracy ocean temperature logger, TC-1121. The newly designed TC-1121 loggers are smaller, more robust, and their sampling intervals can be automatically changed by indicated events. They have been widely used in many mooring systems to study internal wave and ocean mixing. The logger’s fundamental design, noise analysis, calibration, drift test, and a long-term sea trial are discussed in this paper.

  6. Accurately measuring volume of soil samples using low cost Kinect 3D scanner

    NASA Astrophysics Data System (ADS)

    van der Sterre, Boy-Santhos; Hut, Rolf; van de Giesen, Nick

    2013-04-01

    The 3D scanner of the Kinect game controller can be used to increase the accuracy and efficiency of determining in situ soil moisture content. Soil moisture is one of the principal hydrological variables in both the water and energy interactions between soil and atmosphere. Current in situ measurements of soil moisture either rely on indirect measurements (of electromagnetic constants or heat capacity) or on physically taking a sample and weighing it in a lab. The bottleneck in accurately retrieving soil moisture using samples is the determining of the volume of the sample. Currently this is mostly done by the very time consuming "sand cone method" in which the volume were the sample used to sit is filled with sand. We show that 3D scanner that is part of the 150 game controller extension "Kinect" can be used to make 3D scans before and after taking the sample. The accuracy of this method is tested by scanning forms of known volume. This method is less time consuming and less error-prone than using a sand cone.

  7. Accurately measuring volume of soil samples using low cost Kinect 3D scanner

    NASA Astrophysics Data System (ADS)

    van der Sterre, B.; Hut, R.; Van De Giesen, N.

    2012-12-01

    The 3D scanner of the Kinect game controller can be used to increase the accuracy and efficiency of determining in situ soil moisture content. Soil moisture is one of the principal hydrological variables in both the water and energy interactions between soil and atmosphere. Current in situ measurements of soil moisture either rely on indirect measurements (of electromagnetic constants or heat capacity) or on physically taking a sample and weighing it in a lab. The bottleneck in accurately retrieving soil moisture using samples is the determining of the volume of the sample. Currently this is mostly done by the very time consuming "sand cone method" in which the volume were the sample used to sit is filled with sand. We show that 3D scanner that is part of the $150 game controller extension "Kinect" can be used to make 3D scans before and after taking the sample. The accuracy of this method is tested by scanning forms of known volume. This method is less time consuming and less error-prone than using a sand cone.

  8. Major Trends and Portents Related to Information Costs.

    ERIC Educational Resources Information Center

    Wilson, John H., Jr.

    Managers' having to account for cost of information activities is here to stay. Budgeting is going to become more stringent and imaginative. Costs should not be equated with human values--psychological and subjective--which apparently many managers do, feeling that having to cost information activities is degrading. Some trends are: Buy products…

  9. Allele-Specific Quantitative PCR for Accurate, Rapid, and Cost-Effective Genotyping.

    PubMed

    Lee, Han B; Schwab, Tanya L; Koleilat, Alaa; Ata, Hirotaka; Daby, Camden L; Cervera, Roberto Lopez; McNulty, Melissa S; Bostwick, Hannah S; Clark, Karl J

    2016-06-01

    genotypes. ASQ is cost-effective because universal fluorescent probes negate the necessity of designing expensive probes for each locus. PMID:26986823

  10. Allele-Specific Quantitative PCR for Accurate, Rapid, and Cost-Effective Genotyping

    PubMed Central

    Lee, Han B.; Schwab, Tanya L.; Koleilat, Alaa; Ata, Hirotaka; Daby, Camden L.; Cervera, Roberto Lopez; McNulty, Melissa S.; Bostwick, Hannah S.; Clark, Karl J.

    2016-01-01

    genotypes. ASQ is cost-effective because universal fluorescent probes negate the necessity of designing expensive probes for each locus. PMID:26986823

  11. Managerial Cost Accounting for a Technical Information Center.

    ERIC Educational Resources Information Center

    Helmkamp, John G.

    A two-fold solution to the cost information deficiency problem is proposed. A formal managerial cost accounting system is designed expressly for the two information services of retrospective search and selective dissemination. The system was employed during a trial period to test its effectiveness in a technical information center. Once…

  12. Activity-based costing via an information system: an application created for a breast imaging center.

    PubMed

    Hawkins, H; Langer, J; Padua, E; Reaves, J

    2001-06-01

    Activity-based costing (ABC) is a process that enables the estimation of the cost of producing a product or service. More accurate than traditional charge-based approaches, it emphasizes analysis of processes, and more specific identification of both direct and indirect costs. This accuracy is essential in today's healthcare environment, in which managed care organizations necessitate responsible and accountable costing. However, to be successfully utilized, it requires time, effort, expertise, and support. Data collection can be tedious and expensive. By integrating ABC with information management (IM) and systems (IS), organizations can take advantage of the process orientation of both, extend and improve ABC, and decrease resource utilization for ABC projects. In our case study, we have examined the process of a multidisciplinary breast center. We have mapped the constituent activities and established cost drivers. This information has been structured and included in our information system database for subsequent analysis. PMID:11442093

  13. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction

    PubMed Central

    Singh, Ritambhara; Kuscu, Cem; Quinlan, Aaron; Qi, Yanjun; Adli, Mazhar

    2015-01-01

    The CRISPR system has become a powerful biological tool with a wide range of applications. However, improving targeting specificity and accurately predicting potential off-targets remains a significant goal. Here, we introduce a web-based CRISPR/Cas9 Off-target Prediction and Identification Tool (CROP-IT) that performs improved off-target binding and cleavage site predictions. Unlike existing prediction programs that solely use DNA sequence information; CROP-IT integrates whole genome level biological information from existing Cas9 binding and cleavage data sets. Utilizing whole-genome chromatin state information from 125 human cell types further enhances its computational prediction power. Comparative analyses on experimentally validated datasets show that CROP-IT outperforms existing computational algorithms in predicting both Cas9 binding as well as cleavage sites. With a user-friendly web-interface, CROP-IT outputs scored and ranked list of potential off-targets that enables improved guide RNA design and more accurate prediction of Cas9 binding or cleavage sites. PMID:26032770

  14. Accurate protein structure modeling using sparse NMR data and homologous structure information

    PubMed Central

    Thompson, James M.; Sgourakis, Nikolaos G.; Liu, Gaohua; Rossi, Paolo; Tang, Yuefeng; Mills, Jeffrey L.; Szyperski, Thomas; Montelione, Gaetano T.; Baker, David

    2012-01-01

    While information from homologous structures plays a central role in X-ray structure determination by molecular replacement, such information is rarely used in NMR structure determination because it can be incorrect, both locally and globally, when evolutionary relationships are inferred incorrectly or there has been considerable evolutionary structural divergence. Here we describe a method that allows robust modeling of protein structures of up to 225 residues by combining , 13C, and 15N backbone and 13Cβ chemical shift data, distance restraints derived from homologous structures, and a physically realistic all-atom energy function. Accurate models are distinguished from inaccurate models generated using incorrect sequence alignments by requiring that (i) the all-atom energies of models generated using the restraints are lower than models generated in unrestrained calculations and (ii) the low-energy structures converge to within 2.0 Å backbone rmsd over 75% of the protein. Benchmark calculations on known structures and blind targets show that the method can accurately model protein structures, even with very remote homology information, to a backbone rmsd of 1.2–1.9 Å relative to the conventional determined NMR ensembles and of 0.9–1.6 Å relative to X-ray structures for well-defined regions of the protein structures. This approach facilitates the accurate modeling of protein structures using backbone chemical shift data without need for side-chain resonance assignments and extensive analysis of NOESY cross-peak assignments. PMID:22665781

  15. The Basingstoke Orthopaedic Database: a high quality accurate information system for audit.

    PubMed

    Barlow, I W; Flynn, N A; Britton, J M

    1994-11-01

    The accuracy of a computerised audit system custom produced for the Orthopaedic Department has been validated by comparison with operating theatre records and patients' case notes. The study revealed only 2.5 per cent missed entries; of the recorded entries information regarding the nature of the operation was found to be 92.5 per cent complete and 98 per cent accurate. The high percentage accuracy reflects the high degree of medical input in operation of the system. The Basingstoke Orthopaedic Database is flexible, cheap and easy to maintain. Data is stored in a form that is readily applicable to standard software packages. PMID:7598401

  16. The utility of accurate mass and LC elution time information in the analysis of complex proteomes

    SciTech Connect

    Norbeck, Angela D.; Monroe, Matthew E.; Adkins, Joshua N.; Anderson, Kevin K.; Daly, Don S.; Smith, Richard D.

    2005-08-01

    Theoretical tryptic digests of all predicted proteins from the genomes of three organisms of varying complexity were evaluated for specificity and possible utility of combined peptide accurate mass and predicted LC normalized elution time (NET) information. The uniqueness of each peptide was evaluated using its combined mass (+/- 5 ppm and 1 ppm) and NET value (no constraint, +/- 0.05 and 0.01 on a 0-1 NET scale). The set of peptides both underestimates actual biological complexity due to the lack of specific modifications, and overestimates the expected complexity since many proteins will not be present in the sample or observable on the mass spectrometer because of dynamic range limitations. Once a peptide is identified from an LCMS/MS experiment, its mass and elution time is representative of a unique fingerprint for that peptide. The uniqueness of that fingerprint in comparison to that for the other peptides present is indicative of the ability to confidently identify that peptide based on accurate mass and NET measurements. These measurements can be made using HPLC coupled with high resolution MS in a high-throughput manner. Results show that for organisms with comparatively small proteomes, such as Deinococcus radiodurans, modest mass and elution time accuracies are generally adequate for peptide identifications. For more complex proteomes, increasingly accurate easurements are required. However, the majority of proteins should be uniquely identifiable by using LC-MS with mass accuracies within +/- 1 ppm and elution time easurements within +/- 0.01 NET.

  17. Collecting and Reporting Real Costs of Information Systems.

    ERIC Educational Resources Information Center

    Price, Douglas S.

    This document attempts to provide managers and designers of information systems with a usable, practical "building block" system for unit costing. The model is sufficiently flexible to be applicable to a wide variety of cost control requirements; costing elements include project, product, account, organization and function. Design of the cost…

  18. Providing community-based health practitioners with timely and accurate discharge medicines information

    PubMed Central

    2012-01-01

    Background Accurate and timely medication information at the point of discharge is essential for continuity of care. There are scarce data on the clinical significance if poor quality medicines information is passed to the next episode of care. This study aimed to compare the number and clinical significance of medication errors and omission in discharge medicines information, and the timeliness of delivery of this information to community-based health practitioners, between the existing Hospital Discharge Summary (HDS) and a pharmacist prepared Medicines Information Transfer Fax (MITF). Method The study used a sample of 80 hospital patients who were at high risk of medication misadventure, and who had a MITF completed in the study period June – October 2009 at a tertiary referral hospital. The medicines information in participating patients’ MITFs was validated against their Discharge Prescriptions (DP). Medicines information in each patient’s HDS was then compared with their validated MITF. An expert clinical panel reviewed identified medication errors and omissions to determine their clinical significance. The time between patient discharge and the dispatching of the MITF and the HDS to each patient’s community-based practitioners was calculated from hospital records. Results DPs for 77 of the 80 patients were available for comparison with their MITFs. Medicines information in 71 (92%) of the MITFs matched that of the DP. Comparison of the HDS against the MITF revealed that no HDS was prepared for 16 (21%) patients. Of the remaining 61 patients; 33 (54%), had required medications omitted and 38 (62%) had medication errors in their HDS. The Clinical Panel rated the significance of errors or omissions for 70 patients (16 with no HDS prepared and 54 who’s HDS was inconsistent with the validated MITF). In 17 patients the error or omission was rated as insignificant to minor; 23 minor to moderate; 24 moderate to major and 6 major to catastrophic. 28 (35

  19. Accurate, Fast and Cost-Effective Diagnostic Test for Monosomy 1p36 Using Real-Time Quantitative PCR

    PubMed Central

    Cunha, Pricila da Silva; Pena, Heloisa B.; D'Angelo, Carla Sustek; Koiffmann, Celia P.; Rosenfeld, Jill A.; Shaffer, Lisa G.; Stofanko, Martin; Gonçalves-Dornelas, Higgor; Pena, Sérgio Danilo Junho

    2014-01-01

    Monosomy 1p36 is considered the most common subtelomeric deletion syndrome in humans and it accounts for 0.5–0.7% of all the cases of idiopathic intellectual disability. The molecular diagnosis is often made by microarray-based comparative genomic hybridization (aCGH), which has the drawback of being a high-cost technique. However, patients with classic monosomy 1p36 share some typical clinical characteristics that, together with its common prevalence, justify the development of a less expensive, targeted diagnostic method. In this study, we developed a simple, rapid, and inexpensive real-time quantitative PCR (qPCR) assay for targeted diagnosis of monosomy 1p36, easily accessible for low-budget laboratories in developing countries. For this, we have chosen two target genes which are deleted in the majority of patients with monosomy 1p36: PRKCZ and SKI. In total, 39 patients previously diagnosed with monosomy 1p36 by aCGH, fluorescent in situ hybridization (FISH), and/or multiplex ligation-dependent probe amplification (MLPA) all tested positive on our qPCR assay. By simultaneously using these two genes we have been able to detect 1p36 deletions with 100% sensitivity and 100% specificity. We conclude that qPCR of PRKCZ and SKI is a fast and accurate diagnostic test for monosomy 1p36, costing less than 10 US dollars in reagent costs. PMID:24839341

  20. 48 CFR 1515.305-72 - Release of cost information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Release of cost information. 1515.305-72 Section 1515.305-72 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305-72 Release of cost information. (a) In...

  1. 48 CFR 1515.305-72 - Release of cost information.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Release of cost information. 1515.305-72 Section 1515.305-72 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305-72 Release of cost information. (a) In...

  2. 48 CFR 1515.305-72 - Release of cost information.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Release of cost information. 1515.305-72 Section 1515.305-72 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305-72 Release of cost information. (a) In...

  3. Information Technology: Cost Considerations for School Library Media Specialists.

    ERIC Educational Resources Information Center

    Barron, Daniel D.

    2000-01-01

    Discusses the growing dependence on information technology and considers cost factors for school library media specialists. Highlights include emphasizing learning over technology; administrative, assistive, and academic applications; how schools are using information technology; and Web sites that address issues related to information technology…

  4. Social learning strategies and predation risk: minnows copy only when using private information would be costly

    PubMed Central

    Webster, M.M; Laland, K.N

    2008-01-01

    Animals can acquire information from the environment privately, by sampling it directly, or socially, through learning from others. Generally, private information is more accurate, but expensive to acquire, while social information is cheaper but less reliable. Accordingly, the ‘costly information hypothesis’ predicts that individuals will use private information when the costs associated with doing so are low, but that they should increasingly use social information as the costs of using private information rise. While consistent with considerable data, this theory has yet to be directly tested in a satisfactory manner. We tested this hypothesis by giving minnows (Phoxinus phoxinus) a choice between socially demonstrated and non-demonstrated prey patches under conditions of low, indirect and high simulated predation risk. Subjects had no experience (experiment 1) or prior private information that conflicted with the social information provided by the demonstrators (experiment 2). In both experiments, subjects spent more time in the demonstrated patch than in the non-demonstrated patch, and in experiment 1 made fewer switches between patches, when risk was high compared with when it was low. These findings are consistent with the predictions of the costly information hypothesis, and imply that minnows adopt a ‘copy-when-asocial-learning-is-costly’ learning strategy. PMID:18755676

  5. Conditional mutual inclusive information enables accurate quantification of associations in gene regulatory networks.

    PubMed

    Zhang, Xiujun; Zhao, Juan; Hao, Jin-Kao; Zhao, Xing-Ming; Chen, Luonan

    2015-03-11

    Mutual information (MI), a quantity describing the nonlinear dependence between two random variables, has been widely used to construct gene regulatory networks (GRNs). Despite its good performance, MI cannot separate the direct regulations from indirect ones among genes. Although the conditional mutual information (CMI) is able to identify the direct regulations, it generally underestimates the regulation strength, i.e. it may result in false negatives when inferring gene regulations. In this work, to overcome the problems, we propose a novel concept, namely conditional mutual inclusive information (CMI2), to describe the regulations between genes. Furthermore, with CMI2, we develop a new approach, namely CMI2NI (CMI2-based network inference), for reverse-engineering GRNs. In CMI2NI, CMI2 is used to quantify the mutual information between two genes given a third one through calculating the Kullback-Leibler divergence between the postulated distributions of including and excluding the edge between the two genes. The benchmark results on the GRNs from DREAM challenge as well as the SOS DNA repair network in Escherichia coli demonstrate the superior performance of CMI2NI. Specifically, even for gene expression data with small sample size, CMI2NI can not only infer the correct topology of the regulation networks but also accurately quantify the regulation strength between genes. As a case study, CMI2NI was also used to reconstruct cancer-specific GRNs using gene expression data from The Cancer Genome Atlas (TCGA). CMI2NI is freely accessible at http://www.comp-sysbio.org/cmi2ni. PMID:25539927

  6. Conditional mutual inclusive information enables accurate quantification of associations in gene regulatory networks

    PubMed Central

    Zhang, Xiujun; Zhao, Juan; Hao, Jin-Kao; Zhao, Xing-Ming; Chen, Luonan

    2015-01-01

    Mutual information (MI), a quantity describing the nonlinear dependence between two random variables, has been widely used to construct gene regulatory networks (GRNs). Despite its good performance, MI cannot separate the direct regulations from indirect ones among genes. Although the conditional mutual information (CMI) is able to identify the direct regulations, it generally underestimates the regulation strength, i.e. it may result in false negatives when inferring gene regulations. In this work, to overcome the problems, we propose a novel concept, namely conditional mutual inclusive information (CMI2), to describe the regulations between genes. Furthermore, with CMI2, we develop a new approach, namely CMI2NI (CMI2-based network inference), for reverse-engineering GRNs. In CMI2NI, CMI2 is used to quantify the mutual information between two genes given a third one through calculating the Kullback–Leibler divergence between the postulated distributions of including and excluding the edge between the two genes. The benchmark results on the GRNs from DREAM challenge as well as the SOS DNA repair network in Escherichia coli demonstrate the superior performance of CMI2NI. Specifically, even for gene expression data with small sample size, CMI2NI can not only infer the correct topology of the regulation networks but also accurately quantify the regulation strength between genes. As a case study, CMI2NI was also used to reconstruct cancer-specific GRNs using gene expression data from The Cancer Genome Atlas (TCGA). CMI2NI is freely accessible at http://www.comp-sysbio.org/cmi2ni. PMID:25539927

  7. Waste Management Facilities cost information for low-level waste

    SciTech Connect

    Shropshire, D.; Sherick, M.; Biadgi, C.

    1995-06-01

    This report contains preconceptual designs and planning level life-cycle cost estimates for managing low-level waste. The report`s information on treatment, storage, and disposal modules can be integrated to develop total life-cycle costs for various waste management options. A procedure to guide the US Department of Energy and its contractor personnel in the use of cost estimation data is also summarized in this report.

  8. Waste management facilities cost information for hazardous waste. Revision 1

    SciTech Connect

    Shropshire, D.; Sherick, M.; Biagi, C.

    1995-06-01

    This report contains preconceptual designs and planning level life-cycle cost estimates for managing hazardous waste. The report`s information on treatment, storage, and disposal modules can be integrated to develop total life-cycle costs for various waste management options. A procedure to guide the US Department of Energy and its contractor personnel in the use of cost estimation data is also summarized in this report.

  9. Waste management facilities cost information for transuranic waste

    SciTech Connect

    Shropshire, D.; Sherick, M.; Biagi, C.

    1995-06-01

    This report contains preconceptual designs and planning level life-cycle cost estimates for managing transuranic waste. The report`s information on treatment and storage modules can be integrated to develop total life-cycle costs for various waste management options. A procedure to guide the U.S. Department of Energy and its contractor personnel in the use of cost estimation data is also summarized in this report.

  10. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-09

    ... exceed on a daily basis the per diem rates in effect as of the time of travel as set forth in the Federal... Regulation; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services... collection requirement concerning Travel Costs. Public comments are particularly invited on: Whether...

  11. 75 FR 76022 - Agency Information Collection Activities: Cost Submission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... published in the Federal Register (75 FR 57284) on September 20, 2010, allowing for a 60-day comment period... SECURITY Customs and Border Protection Agency Information Collection Activities: Cost Submission AGENCY: U... approval in accordance with the Paperwork Reduction Act: Cost Submission (CBP Form 247). This is a...

  12. 76 FR 35218 - Federal Acquisition Regulation; Information Collection; Cost or Pricing Data Requirements and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... Regulation; Information Collection; Cost or Pricing Data Requirements and Information Other Than Cost or... requirement concerning cost or pricing data requirements and information other than cost or pricing data... Information Collection 9000- 0013, Cost or Pricing Data Requirements and Information Other Than Cost...

  13. Development and Validation of a Fast, Accurate and Cost-Effective Aeroservoelastic Method on Advanced Parallel Computing Systems

    NASA Technical Reports Server (NTRS)

    Goodwin, Sabine A.; Raj, P.

    1999-01-01

    Progress to date towards the development and validation of a fast, accurate and cost-effective aeroelastic method for advanced parallel computing platforms such as the IBM SP2 and the SGI Origin 2000 is presented in this paper. The ENSAERO code, developed at the NASA-Ames Research Center has been selected for this effort. The code allows for the computation of aeroelastic responses by simultaneously integrating the Euler or Navier-Stokes equations and the modal structural equations of motion. To assess the computational performance and accuracy of the ENSAERO code, this paper reports the results of the Navier-Stokes simulations of the transonic flow over a flexible aeroelastic wing body configuration. In addition, a forced harmonic oscillation analysis in the frequency domain and an analysis in the time domain are done on a wing undergoing a rigid pitch and plunge motion. Finally, to demonstrate the ENSAERO flutter-analysis capability, aeroelastic Euler and Navier-Stokes computations on an L-1011 wind tunnel model including pylon, nacelle and empennage are underway. All computational solutions are compared with experimental data to assess the level of accuracy of ENSAERO. As the computations described above are performed, a meticulous log of computational performance in terms of wall clock time, execution speed, memory and disk storage is kept. Code scalability is also demonstrated by studying the impact of varying the number of processors on computational performance on the IBM SP2 and the Origin 2000 systems.

  14. Bar codes and intrinsic-surface-roughness tag: Accurate and low-cost accountability for CFE. [Conventional force equipment (CFE)

    SciTech Connect

    DeVolpi, A.; Palm, R.

    1990-01-01

    CFE poses a number of verification challenges that could be met in part by an accurate and low-cost means of aiding in accountability of treaty-limited equipment. Although the treaty as signed does not explicitly call for the use of tags, there is a provision for recording serial numbers'' and placing special marks'' on equipment subject to reduction. There are approximately 150,000 residual items to be tracked for CFE-I, about half for each alliance of state parties. These highly mobile items are subject to complex treaty limitations: deployment limits and zones, ceilings subceilings, holdings and allowances. There are controls and requirements for storage, conversion, and reduction. In addition, there are national security concerns regarding modernization and mobilization capability. As written into the treaty, a heavy reliance has been placed on human inspectors for CFE verification. Inspectors will mostly make visual observations and photographs as the means of monitoring compliance; these observations can be recorded by handwriting or keyed into a laptop computer. CFE is now less a treaty between two alliances than a treaty among 22 state parties, with inspection data an reports to be shared with each party in the official languages designated by CSCE. One of the potential roles for bar-coded tags would be to provide a universal, exchangable, computer-compatible language for tracking TLE. 10 figs.

  15. Accurate path integral molecular dynamics simulation of ab-initio water at near-zero added cost

    NASA Astrophysics Data System (ADS)

    Elton, Daniel; Fritz, Michelle; Soler, José; Fernandez-Serra, Marivi

    It is now established that nuclear quantum motion plays an important role in determining water's structure and dynamics. These effects are important to consider when evaluating DFT functionals and attempting to develop better ones for water. The standard way of treating nuclear quantum effects, path integral molecular dynamics (PIMD), multiplies the number of energy/force calculations by the number of beads, which is typically 32. Here we introduce a method whereby PIMD can be incorporated into a DFT molecular dynamics simulation at virtually zero cost. The method is based on the cluster (many body) expansion of the energy. We first subtract the DFT monomer energies, using a custom DFT-based monomer potential energy surface. The evolution of the PIMD beads is then performed using only the more-accurate Partridge-Schwenke monomer energy surface. The DFT calculations are done using the centroid positions. Various bead thermostats can be employed to speed up the sampling of the quantum ensemble. The method bears some resemblance to multiple timestep algorithms and other schemes used to speed up PIMD with classical force fields. We show that our method correctly captures some of key effects of nuclear quantum motion on both the structure and dynamics of water. We acknowledge support from DOE Award No. DE-FG02-09ER16052 (D.E.) and DOE Early Career Award No. DE-SC0003871 (M.V.F.S.).

  16. Alignment of capillary electrophoresis-mass spectrometry datasets using accurate mass information.

    PubMed

    Nevedomskaya, Ekaterina; Derks, Rico; Deelder, André M; Mayboroda, Oleg A; Palmblad, Magnus

    2009-12-01

    Capillary electrophoresis-mass spectrometry (CE-MS) is a powerful technique for the analysis of small soluble compounds in biological fluids. A major drawback of CE is the poor migration time reproducibility, which makes it difficult to combine data from different experiments and correctly assign compounds. A number of alignment algorithms have been developed but not all of them can cope with large and irregular time shifts between CE-MS runs. Here we present a genetic algorithm designed for alignment of CE-MS data using accurate mass information. The utility of the algorithm was demonstrated on real data, and the results were compared with one of the existing packages. The new algorithm showed a significant reduction of elution time variation in the aligned datasets. The importance of mass accuracy for the performance of the algorithm was also demonstrated by comparing alignments of datasets from a standard time-of-flight (TOF) instrument with those from the new ultrahigh resolution TOF maXis (Bruker Daltonics). PMID:19826795

  17. 48 CFR 239.7406 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION OF INFORMATION TECHNOLOGY Telecommunications Services 239.7406 Cost or pricing data and information other than cost or pricing data. (a) Common carriers are not required to submit cost or pricing... information other than cost or pricing data. 239.7406 Section 239.7406 Federal Acquisition Regulations...

  18. Irreversible information loss: Fundamental notions and entropy costs

    NASA Astrophysics Data System (ADS)

    Anderson, Neal G.

    2014-09-01

    Landauer's Principle (LP) associates an entropy increase with the irreversible loss of information from a physical system. Clear statement, unambiguous interpretation, and proper application of LP requires precise, mutually consistent, and sufficiently general definitions for a set of interlocking fundamental notions and quantities (entropy, information, irreversibility, erasure). In this work, we critically assess some common definitions and quantities used or implied in statements of LP, and reconsider their definition within an alternative “referential” approach to physical information theory that embodies an overtly relational conception of physical information. We prove an inequality on the entropic cost of irreversible information loss within this context, as well as “referential analogs” of LP and its more general restatement by Bennett. Advantages of the referential approach for establishing fundamental limits on the physical costs of irreversible information loss in communication and computing systems are discussed throughout.

  19. Highly Accurate Prediction of Protein-Protein Interactions via Incorporating Evolutionary Information and Physicochemical Characteristics.

    PubMed

    Li, Zheng-Wei; You, Zhu-Hong; Chen, Xing; Gui, Jie; Nie, Ru

    2016-01-01

    Protein-protein interactions (PPIs) occur at almost all levels of cell functions and play crucial roles in various cellular processes. Thus, identification of PPIs is critical for deciphering the molecular mechanisms and further providing insight into biological processes. Although a variety of high-throughput experimental techniques have been developed to identify PPIs, existing PPI pairs by experimental approaches only cover a small fraction of the whole PPI networks, and further, those approaches hold inherent disadvantages, such as being time-consuming, expensive, and having high false positive rate. Therefore, it is urgent and imperative to develop automatic in silico approaches to predict PPIs efficiently and accurately. In this article, we propose a novel mixture of physicochemical and evolutionary-based feature extraction method for predicting PPIs using our newly developed discriminative vector machine (DVM) classifier. The improvements of the proposed method mainly consist in introducing an effective feature extraction method that can capture discriminative features from the evolutionary-based information and physicochemical characteristics, and then a powerful and robust DVM classifier is employed. To the best of our knowledge, it is the first time that DVM model is applied to the field of bioinformatics. When applying the proposed method to the Yeast and Helicobacter pylori (H. pylori) datasets, we obtain excellent prediction accuracies of 94.35% and 90.61%, respectively. The computational results indicate that our method is effective and robust for predicting PPIs, and can be taken as a useful supplementary tool to the traditional experimental methods for future proteomics research. PMID:27571061

  20. Linking cost control measures to health care services by using activity-based information.

    PubMed

    Hoyt, R E; Lay, C M

    1995-11-01

    Canada's health care institutions are under pressure to limit expenditures, maintain or increase productivity, and assimilate new technology. Even though more than 75% of hospital operating expenditures are controllable, according to a study by the Economic Council of Canada, cost systems are needed to provided essential management information. The new Canadian Management Information System (MIS) Guidelines for health care are designed to provide accurate cost measurement of patient treatment and to help managers evaluate the impact of planned program changes on areas of operational responsibility. Other potential benefits of implementing the MIS guidelines include correcting dysfunctional funding of health care units with benchmarking and setting high reporting standards for resource use at the patient level (MIS, 1991). This paper focuses on one important aspect of bringing these costs under control by examining the relation between cost deviations (variances) and underlying cost drivers. Our discussion will lead to the conclusion that incompatibility of DRG methodology and traditional cost accounting models may be an important source of cost variability within diagnostically-related disease groupings. PMID:10153271

  1. Thermodynamic Costs of Information Processing in Sensory Adaptation

    PubMed Central

    Sartori, Pablo; Granger, Léo; Lee, Chiu Fan; Horowitz, Jordan M.

    2014-01-01

    Biological sensory systems react to changes in their surroundings. They are characterized by fast response and slow adaptation to varying environmental cues. Insofar as sensory adaptive systems map environmental changes to changes of their internal degrees of freedom, they can be regarded as computational devices manipulating information. Landauer established that information is ultimately physical, and its manipulation subject to the entropic and energetic bounds of thermodynamics. Thus the fundamental costs of biological sensory adaptation can be elucidated by tracking how the information the system has about its environment is altered. These bounds are particularly relevant for small organisms, which unlike everyday computers, operate at very low energies. In this paper, we establish a general framework for the thermodynamics of information processing in sensing. With it, we quantify how during sensory adaptation information about the past is erased, while information about the present is gathered. This process produces entropy larger than the amount of old information erased and has an energetic cost bounded by the amount of new information written to memory. We apply these principles to the E. coli's chemotaxis pathway during binary ligand concentration changes. In this regime, we quantify the amount of information stored by each methyl group and show that receptors consume energy in the range of the information-theoretic minimum. Our work provides a basis for further inquiries into more complex phenomena, such as gradient sensing and frequency response. PMID:25503948

  2. 48 CFR 570.110 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Cost or pricing data and information other than cost or pricing data. 570.110 Section 570.110 Federal Acquisition Regulations System... PROPERTY General 570.110 Cost or pricing data and information other than cost or pricing data. (a)...

  3. 48 CFR 570.110 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Cost or pricing data and information other than cost or pricing data. 570.110 Section 570.110 Federal Acquisition Regulations System... PROPERTY General 570.110 Cost or pricing data and information other than cost or pricing data. (a)...

  4. 48 CFR 570.110 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Cost or pricing data and information other than cost or pricing data. 570.110 Section 570.110 Federal Acquisition Regulations System... PROPERTY General 570.110 Cost or pricing data and information other than cost or pricing data. (a)...

  5. 48 CFR 570.110 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Cost or pricing data and information other than cost or pricing data. 570.110 Section 570.110 Federal Acquisition Regulations System... PROPERTY General 570.110 Cost or pricing data and information other than cost or pricing data. (a)...

  6. 48 CFR 570.110 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Cost or pricing data and information other than cost or pricing data. 570.110 Section 570.110 Federal Acquisition Regulations System... PROPERTY General 570.110 Cost or pricing data and information other than cost or pricing data. (a)...

  7. Information Technology: A Tool to Cut Health Care Costs

    NASA Technical Reports Server (NTRS)

    Mukkamala, Ravi; Maly, K. J.; Overstreet, C. M.; Foudriat, E. C.

    1996-01-01

    Old Dominion University embarked on a project to see how current computer technology could be applied to reduce the cost and or to improve the efficiency of health care services. We designed and built a prototype for an integrated medical record system (MRS). The MRS is written in Tool control language/Tool kit (Tcl/Tk). While the initial version of the prototype had patient information hard coded into the system, later versions used an INGRES database for storing patient information. Currently, we have proposed an object-oriented model for implementing MRS. These projects involve developing information systems for physicians and medical researchers to enhance their ability for improved treatment at reduced costs. The move to computerized patient records is well underway, several standards exist for laboratory records, and several groups are working on standards for other portions of the patient record.

  8. Accurate refinement of docked protein complexes using evolutionary information and deep learning.

    PubMed

    Akbal-Delibas, Bahar; Farhoodi, Roshanak; Pomplun, Marc; Haspel, Nurit

    2016-06-01

    One of the major challenges for protein docking methods is to accurately discriminate native-like structures from false positives. Docking methods are often inaccurate and the results have to be refined and re-ranked to obtain native-like complexes and remove outliers. In a previous work, we introduced AccuRefiner, a machine learning based tool for refining protein-protein complexes. Given a docked complex, the refinement tool produces a small set of refined versions of the input complex, with lower root-mean-square-deviation (RMSD) of atomic positions with respect to the native structure. The method employs a unique ranking tool that accurately predicts the RMSD of docked complexes with respect to the native structure. In this work, we use a deep learning network with a similar set of features and five layers. We show that a properly trained deep learning network can accurately predict the RMSD of a docked complex with 1.40 Å error margin on average, by approximating the complex relationship between a wide set of scoring function terms and the RMSD of a docked structure. The network was trained on 35000 unbound docking complexes generated by RosettaDock. We tested our method on 25 different putative docked complexes produced also by RosettaDock for five proteins that were not included in the training data. The results demonstrate that the high accuracy of the ranking tool enables AccuRefiner to consistently choose the refinement candidates with lower RMSD values compared to the coarsely docked input structures. PMID:26846813

  9. 30 CFR 251.13 - Reimbursement for the costs of reproducing data and information and certain processing costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Reimbursement for the costs of reproducing data and information and certain processing costs. 251.13 Section 251.13 Mineral Resources MINERALS... certain processing costs. (a) MMS will reimburse you or a third party for reasonable costs of...

  10. 48 CFR 239.7406 - Cost or pricing data and information other than cost or pricing data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Cost or pricing data and information other than cost or pricing data. 239.7406 Section 239.7406 Federal Acquisition Regulations System... ACQUISITION OF INFORMATION TECHNOLOGY Telecommunications Services 239.7406 Cost or pricing data...

  11. 77 FR 63804 - Federal Acquisition Regulation; Information Collection; Indirect Cost Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Regulation; Information Collection; Indirect Cost Rates AGENCY: Department of Defense (DOD), General Services... requirement concerning Indirect Cost Rates. Public comments are particularly invited on: Whether this... Information Collection 9000- 0069, Indirect Cost Rates, by any of the following methods:...

  12. Can Raters with Reduced Job Descriptive Information Provide Accurate Position Analysis Questionnaire (PAQ) Ratings?

    ERIC Educational Resources Information Center

    Friedman, Lee; Harvey, Robert J.

    1986-01-01

    Job-naive raters provided with job descriptive information made Position Analysis Questionnaire (PAQ) ratings which were validated against ratings of job analysts who were also job content experts. None of the reduced job descriptive information conditions enabled job-naive raters to obtain either acceptable levels of convergent validity with…

  13. Dynamic disorder and the energetic costs of information transduction

    SciTech Connect

    Thill, Peter

    2014-07-07

    We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.

  14. Dynamic disorder and the energetic costs of information transduction

    NASA Astrophysics Data System (ADS)

    Thill, Peter

    2014-07-01

    We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.

  15. Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision.

    PubMed

    Roses, A D

    2016-02-01

    Structural variants (SVs) include all insertions, deletions, and rearrangements in the genome, with several common types of nucleotide repeats including single sequence repeats, short tandem repeats, and insertion-deletion length variants. Polyallelic SVs provide highly informative markers for association studies with well-phenotyped cohorts. SVs can influence gene regulation by affecting epigenetics, transcription, splicing, and/or translation. Accurate assays of polyallelic SV loci are required to define the range and allele frequency of variable length alleles. PMID:26517180

  16. Financing New Information Access Paradigms, or Why Academic Information Managers Need Cost Models.

    ERIC Educational Resources Information Center

    Katz, Richard N.

    1992-01-01

    This speech addresses the need for institutions of higher education to develop economic models to assist in the management of academic information systems (including both print and computerized systems) in light of restricted economic resources. Steps in development of a comprehensive model of information costs are outlined. (DB)

  17. 75 FR 10455 - Information Collection; Timber Purchaser Cost and Sales Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ..., (2) manufacturing cost, (3) falling and bucking costs, (4) skidding and loading costs, and (5...; ] DEPARTMENT OF AGRICULTURE Forest Service Information Collection; Timber Purchaser Cost and Sales Data AGENCY... organizations on the extension of a currently approved information collection, Timber Purchaser Cost and...

  18. Exploratory Movement Generates Higher-Order Information That Is Sufficient for Accurate Perception of Scaled Egocentric Distance

    PubMed Central

    Mantel, Bruno; Stoffregen, Thomas A.; Campbell, Alain; Bardy, Benoît G.

    2015-01-01

    Body movement influences the structure of multiple forms of ambient energy, including optics and gravito-inertial force. Some researchers have argued that egocentric distance is derived from inferential integration of visual and non-visual stimulation. We suggest that accurate information about egocentric distance exists in perceptual stimulation as higher-order patterns that extend across optics and inertia. We formalize a pattern that specifies the egocentric distance of a stationary object across higher-order relations between optics and inertia. This higher-order parameter is created by self-generated movement of the perceiver in inertial space relative to the illuminated environment. For this reason, we placed minimal restrictions on the exploratory movements of our participants. We asked whether humans can detect and use the information available in this higher-order pattern. Participants judged whether a virtual object was within reach. We manipulated relations between body movement and the ambient structure of optics and inertia. Judgments were precise and accurate when the higher-order optical-inertial parameter was available. When only optic flow was available, judgments were poor. Our results reveal that participants perceived egocentric distance from the higher-order, optical-inertial consequences of their own exploratory activity. Analysis of participants’ movement trajectories revealed that self-selected movements were complex, and tended to optimize availability of the optical-inertial pattern that specifies egocentric distance. We argue that accurate information about egocentric distance exists in higher-order patterns of ambient energy, that self-generated movement can generate these higher-order patterns, and that these patterns can be detected and used to support perception of egocentric distance that is precise and accurate. PMID:25856410

  19. MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution

    PubMed Central

    Cai, Wanshi; Mao, Fengbiao; Teng, Huajing; Cai, Tao; Zhao, Fangqing; Wu, Jinyu; Sun, Zhong Sheng

    2015-01-01

    Organisms and cells, in response to environmental influences or during development, undergo considerable changes in DNA methylation on a genome-wide scale, which are linked to a variety of biological processes. Using MethylC-seq to decipher DNA methylome at single-base resolution is prohibitively costly. In this study, we develop a novel approach, named MBRidge, to detect the methylation levels of repertoire CpGs, by innovatively introducing C-hydroxylmethylated adapters and bisulfate treatment into the MeDIP-seq protocol and employing ridge regression in data analysis. A systematic evaluation of DNA methylome in a human ovarian cell line T29 showed that MBRidge achieved high correlation (R > 0.90) with much less cost (∼10%) in comparison with MethylC-seq. We further applied MBRidge to profiling DNA methylome in T29H, an oncogenic counterpart of T29's. By comparing methylomes of T29H and T29, we identified 131790 differential methylation regions (DMRs), which are mainly enriched in carcinogenesis-related pathways. These are substantially different from 7567 DMRs that were obtained by RRBS and related with cell development or differentiation. The integrated analysis of DMRs in the promoter and expression of DMR-corresponding genes revealed that DNA methylation enforced reverse regulation of gene expression, depending on the distance from the proximal DMR to transcription starting sites in both mRNA and lncRNA. Taken together, our results demonstrate that MBRidge is an efficient and cost-effective method that can be widely applied to profiling DNA methylomes. PMID:26078362

  20. MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution.

    PubMed

    Cai, Wanshi; Mao, Fengbiao; Teng, Huajing; Cai, Tao; Zhao, Fangqing; Wu, Jinyu; Sun, Zhong Sheng

    2015-08-01

    Organisms and cells, in response to environmental influences or during development, undergo considerable changes in DNA methylation on a genome-wide scale, which are linked to a variety of biological processes. Using MethylC-seq to decipher DNA methylome at single-base resolution is prohibitively costly. In this study, we develop a novel approach, named MBRidge, to detect the methylation levels of repertoire CpGs, by innovatively introducing C-hydroxylmethylated adapters and bisulfate treatment into the MeDIP-seq protocol and employing ridge regression in data analysis. A systematic evaluation of DNA methylome in a human ovarian cell line T29 showed that MBRidge achieved high correlation (R > 0.90) with much less cost (∼10%) in comparison with MethylC-seq. We further applied MBRidge to profiling DNA methylome in T29H, an oncogenic counterpart of T29's. By comparing methylomes of T29H and T29, we identified 131790 differential methylation regions (DMRs), which are mainly enriched in carcinogenesis-related pathways. These are substantially different from 7567 DMRs that were obtained by RRBS and related with cell development or differentiation. The integrated analysis of DMRs in the promoter and expression of DMR-corresponding genes revealed that DNA methylation enforced reverse regulation of gene expression, depending on the distance from the proximal DMR to transcription starting sites in both mRNA and lncRNA. Taken together, our results demonstrate that MBRidge is an efficient and cost-effective method that can be widely applied to profiling DNA methylomes. PMID:26078362

  1. Cost and Schedule Control Systems Criteria for contract performance measurement. Information pamphlet

    SciTech Connect

    1984-05-01

    The purpose of this pamphlet is to inform interested DOE and industry personnel about the basic concepts and general requirements of the Cost and Schedule Control Systems Criteria (CSCSC) of DOE Order 2250.1A. the CSCSC do not represent a management system nor do they prescribe specific methods of organization or operation. The criteria are intended to serve as standards of measuring adequacy of management control systems. Objectives in using the criteria are: (1) to provide an accurate status of contract progress; (2) to provide early visibility to problems - prevent surprises; (3) to improve estimated final cost projections; (4) to improve on shortcomings of prior requirements; and (5) to minimize proliferation of systems and data problems. The CSCSC contain thirty-five criteria which are grouped into five categories: organization; planning and budgeting; accounting; analysis; and revisions and access to data.

  2. Surgical biopsy with intra-operative frozen section. An accurate and cost-effective method for diagnosis of musculoskeletal sarcomas.

    PubMed

    Ashford, R U; McCarthy, S W; Scolyer, R A; Bonar, S F; Karim, R Z; Stalley, P D

    2006-09-01

    The most appropriate protocol for the biopsy of musculoskeletal tumours is controversial, with some authors advocating CT-guided core biopsy. At our hospital the initial biopsies of most musculoskeletal tumours has been by operative core biopsy with evaluation by frozen section which determines whether diagnostic tissue has been obtained and, if possible, gives the definitive diagnosis. In order to determine the accuracy and cost-effectiveness of this protocol we have undertaken a retrospective audit of biopsies of musculoskeletal tumours performed over a period of two years. A total of 104 patients had biopsies according to this regime. All gave the diagnosis apart from one minor error which did not alter the management of the patient. There was no requirement for re-biopsy. This protocol was more labour-intensive and 38% more costly than CT-guided core biopsy (AU$1804 vs AU$1308). However, the accuracy and avoidance of the anxiety associated with repeat biopsy outweighed these disadvantages. PMID:16943474

  3. QuShape: Rapid, accurate, and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis

    PubMed Central

    Karabiber, Fethullah; McGinnis, Jennifer L.; Favorov, Oleg V.; Weeks, Kevin M.

    2013-01-01

    Chemical probing of RNA and DNA structure is a widely used and highly informative approach for examining nucleic acid structure and for evaluating interactions with protein and small-molecule ligands. Use of capillary electrophoresis to analyze chemical probing experiments yields hundreds of nucleotides of information per experiment and can be performed on automated instruments. Extraction of the information from capillary electrophoresis electropherograms is a computationally intensive multistep analytical process, and no current software provides rapid, automated, and accurate data analysis. To overcome this bottleneck, we developed a platform-independent, user-friendly software package, QuShape, that yields quantitatively accurate nucleotide reactivity information with minimal user supervision. QuShape incorporates newly developed algorithms for signal decay correction, alignment of time-varying signals within and across capillaries and relative to the RNA nucleotide sequence, and signal scaling across channels or experiments. An analysis-by-reference option enables multiple, related experiments to be fully analyzed in minutes. We illustrate the usefulness and robustness of QuShape by analysis of RNA SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension) experiments. PMID:23188808

  4. Environmental indivisibilities and information costs: fanaticism, agnosticism, and intellectual progress

    SciTech Connect

    Olson, M.

    1982-05-01

    This analysis suggests several distinctive policy recommendations about environmental problems. One is that some of the alarms about ecological catastrophes cannot simply be dismissed, even when some of those who sound the alarms seem almost fanatic. The information needed to be sure one way or another is simply lacking, and may not be attainable at reasonable cost for a long time. We are therefore left with inevitable risk. Ecological systems could also be incomparably more robust than the alarmists claim, so we might also be worrying needlessly. The implication for environmental and ecological research is that we should not exprect that it will produce conclusive information, but should fund a lot of it anyhow. If previous research has produced few compelling results, valid information about these problems is scarce and therefore more valuable. The harvest of research in the areas characterized by indivisibilities is then poor but precious knowledge. If it is important to be able to change behavior quickly, when and if we finally get the information that the ecosystem can't take any more, then it is important that we have the open-mindedness needed to change our views and policies the moment decisive information arrives. Those who shout wolf too often, and those who are sure there are no wolves around, could be our undoing.

  5. Combining Evolutionary Information and an Iterative Sampling Strategy for Accurate Protein Structure Prediction

    PubMed Central

    Braun, Tatjana; Koehler Leman, Julia; Lange, Oliver F.

    2015-01-01

    Recent work has shown that the accuracy of ab initio structure prediction can be significantly improved by integrating evolutionary information in form of intra-protein residue-residue contacts. Following this seminal result, much effort is put into the improvement of contact predictions. However, there is also a substantial need to develop structure prediction protocols tailored to the type of restraints gained by contact predictions. Here, we present a structure prediction protocol that combines evolutionary information with the resolution-adapted structural recombination approach of Rosetta, called RASREC. Compared to the classic Rosetta ab initio protocol, RASREC achieves improved sampling, better convergence and higher robustness against incorrect distance restraints, making it the ideal sampling strategy for the stated problem. To demonstrate the accuracy of our protocol, we tested the approach on a diverse set of 28 globular proteins. Our method is able to converge for 26 out of the 28 targets and improves the average TM-score of the entire benchmark set from 0.55 to 0.72 when compared to the top ranked models obtained by the EVFold web server using identical contact predictions. Using a smaller benchmark, we furthermore show that the prediction accuracy of our method is only slightly reduced when the contact prediction accuracy is comparatively low. This observation is of special interest for protein sequences that only have a limited number of homologs. PMID:26713437

  6. Cosis: cost of service information system. Model-simulation

    SciTech Connect

    Not Available

    1982-05-10

    The Cost of Service Information System of models (COSIS) is an integrated, electric utility strategic planning system. This system of five models, written in FORTRAN, provides a framework for the examination of a wide range of utility strategics or environmental conditions. The five models are: (1) LAm which derives projected load duration curves for up to 30 years on a system level to serve as input to capacity expansion and production simulating models. (2) PCS (Production Cost Simulation) which projects energy production by generating unit as a function of the unit's equivalent availability, capacity, loading position, and the energy supply demands on the system. (3) FRED which calculates the monthly average profile at the system level from the historical or reference year. (4) RAm (Regulatory Analysis Model) which performs up to 30 years of financial statements for an electric utility. (5) ACE which performs cost allocations based on financial projections from ths RAm model. The models are written in Fortran for implementation on UNIVAC 1100/84 computers operating under OS.

  7. Accurately decoding visual information from fMRI data obtained in a realistic virtual environment

    PubMed Central

    Floren, Andrew; Naylor, Bruce; Miikkulainen, Risto; Ress, David

    2015-01-01

    Three-dimensional interactive virtual environments (VEs) are a powerful tool for brain-imaging based cognitive neuroscience that are presently under-utilized. This paper presents machine-learning based methods for identifying brain states induced by realistic VEs with improved accuracy as well as the capability for mapping their spatial topography on the neocortex. VEs provide the ability to study the brain under conditions closer to the environment in which humans evolved, and thus to probe deeper into the complexities of human cognition. As a test case, we designed a stimulus to reflect a military combat situation in the Middle East, motivated by the potential of using real-time functional magnetic resonance imaging (fMRI) in the treatment of post-traumatic stress disorder. Each subject experienced moving through the virtual town where they encountered 1–6 animated combatants at different locations, while fMRI data was collected. To analyze the data from what is, compared to most studies, more complex and less controlled stimuli, we employed statistical machine learning in the form of Multi-Voxel Pattern Analysis (MVPA) with special attention given to artificial Neural Networks (NN). Extensions to NN that exploit the block structure of the stimulus were developed to improve the accuracy of the classification, achieving performances from 58 to 93% (chance was 16.7%) with six subjects. This demonstrates that MVPA can decode a complex cognitive state, viewing a number of characters, in a dynamic virtual environment. To better understand the source of this information in the brain, a novel form of sensitivity analysis was developed to use NN to quantify the degree to which each voxel contributed to classification. Compared with maps produced by general linear models and the searchlight approach, these sensitivity maps revealed a more diverse pattern of information relevant to the classification of cognitive state. PMID:26106315

  8. An accurate cost effective DFT approach to study the sensing behaviour of polypyrrole towards nitrate ions in gas and aqueous phases.

    PubMed

    Wasim, Fatima; Mahmood, Tariq; Ayub, Khurshid

    2016-07-28

    Density functional theory (DFT) calculations have been performed to study the response of polypyrrole towards nitrate ions in gas and aqueous phases. First, an accurate estimate of interaction energies is obtained by methods calibrated against the gold standard CCSD(T) method. Then, a number of low cost DFT methods are also evaluated for their ability to accurately estimate the binding energies of polymer-nitrate complexes. The low cost methods evaluated here include dispersion corrected potential (DCP), Grimme's D3 correction, counterpoise correction of the B3LYP method, and Minnesota functionals (M05-2X). The interaction energies calculated using the counterpoise (CP) correction and DCP methods at the B3LYP level are in better agreement with the interaction energies calculated using the calibrated methods. The interaction energies of an infinite polymer (polypyrrole) with nitrate ions are calculated by a variety of low cost methods in order to find the associated errors. The electronic and spectroscopic properties of polypyrrole oligomers nPy (where n = 1-9) and nPy-NO3(-) complexes are calculated, and then extrapolated for an infinite polymer through a second degree polynomial fit. Charge analysis, frontier molecular orbital (FMO) analysis and density of state studies also reveal the sensing ability of polypyrrole towards nitrate ions. Interaction energies, charge analysis and density of states analyses illustrate that the response of polypyrrole towards nitrate ions is considerably reduced in the aqueous medium (compared to the gas phase). PMID:27375267

  9. The cost of forming more accurate impressions: accuracy-motivated perceivers see the personality of others more distinctively but less normatively than perceivers without an explicit goal.

    PubMed

    Biesanz, Jeremy C; Human, Lauren J

    2010-04-01

    Does the motivation to form accurate impressions actually improve accuracy? The present work extended Kenny's (1991, 1994) weighted-average model (WAM)--a theoretical model of the factors that influence agreement among personality judgments--to examine two components of interpersonal perception: distinctive and normative accuracy. WAM predicts that an accuracy motivation should enhance distinctive accuracy but decrease normative accuracy. In other words, the impressions of a perceiver with an accuracy motivation will correspond more with the target person's unique characteristics and less with the characteristics of the average person. Perceivers randomly assigned to receive the social goal of forming accurate impressions, which was communicated through a single-sentence instruction, achieved higher levels of distinctive self-other agreement but lower levels of normative agreement compared with perceivers not given an explicit impression-formation goal. The results suggest that people motivated to form accurate impressions do indeed become more accurate, but at the cost of seeing others less normatively and, in particular, less positively. PMID:20424106

  10. Accurate prediction of interfacial residues in two-domain proteins using evolutionary information: implications for three-dimensional modeling.

    PubMed

    Bhaskara, Ramachandra M; Padhi, Amrita; Srinivasan, Narayanaswamy

    2014-07-01

    With the preponderance of multidomain proteins in eukaryotic genomes, it is essential to recognize the constituent domains and their functions. Often function involves communications across the domain interfaces, and the knowledge of the interacting sites is essential to our understanding of the structure-function relationship. Using evolutionary information extracted from homologous domains in at least two diverse domain architectures (single and multidomain), we predict the interface residues corresponding to domains from the two-domain proteins. We also use information from the three-dimensional structures of individual domains of two-domain proteins to train naïve Bayes classifier model to predict the interfacial residues. Our predictions are highly accurate (∼85%) and specific (∼95%) to the domain-domain interfaces. This method is specific to multidomain proteins which contain domains in at least more than one protein architectural context. Using predicted residues to constrain domain-domain interaction, rigid-body docking was able to provide us with accurate full-length protein structures with correct orientation of domains. We believe that these results can be of considerable interest toward rational protein and interaction design, apart from providing us with valuable information on the nature of interactions. PMID:24375512

  11. 77 FR 20012 - Federal Acquisition Regulation; Information Collection; Corporate Aircraft Costs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... Regulation; Information Collection; Corporate Aircraft Costs AGENCY: Department of Defense (DOD), General... collection requirement concerning corporate aircraft costs. Public comments are particularly invited on..., Corporate Aircraft Costs, by any of the following methods: Regulations.gov :...

  12. Accurate molecular dynamics and nuclear quantum effects at low cost by multiple steps in real and imaginary time: Using density functional theory to accelerate wavefunction methods

    NASA Astrophysics Data System (ADS)

    Kapil, V.; VandeVondele, J.; Ceriotti, M.

    2016-02-01

    The development and implementation of increasingly accurate methods for electronic structure calculations mean that, for many atomistic simulation problems, treating light nuclei as classical particles is now one of the most serious approximations. Even though recent developments have significantly reduced the overhead for modeling the quantum nature of the nuclei, the cost is still prohibitive when combined with advanced electronic structure methods. Here we present how multiple time step integrators can be combined with ring-polymer contraction techniques (effectively, multiple time stepping in imaginary time) to reduce virtually to zero the overhead of modelling nuclear quantum effects, while describing inter-atomic forces at high levels of electronic structure theory. This is demonstrated for a combination of MP2 and semi-local DFT applied to the Zundel cation. The approach can be seamlessly combined with other methods to reduce the computational cost of path integral calculations, such as high-order factorizations of the Boltzmann operator or generalized Langevin equation thermostats.

  13. CoAIMs: A Cost-Effective Panel of Ancestry Informative Markers for Determining Continental Origins

    PubMed Central

    Londin, Eric R.; Keller, Margaret A.; Maista, Cathleen; Smith, Gretchen; Mamounas, Laura A.; Zhang, Ran; Madore, Steven J.; Gwinn, Katrina; Corriveau, Roderick A.

    2010-01-01

    Background Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an important role in optimizing treatment. As modern medicine moves towards using personal genetic information for clinical applications, it is important to determine genetic ancestry in an accurate, cost-effective and efficient manner. Self-identified race is a common method used to track and control for population stratification; however, social constructs of race are not necessarily informative for genetic applications. The use of ancestry informative markers (AIMs) is a more accurate method for determining genetic ancestry for the purposes of population stratification. Methodology/Principal Findings Here we introduce a novel panel of 36 microsatellite (MSAT) AIMs that determines continental admixture proportions. This panel, which we have named Continental Ancestry Informative Markers or CoAIMs, consists of MSAT AIMs that were chosen based upon their measure of genetic variance (Fst), allele frequencies and their suitability for efficient genotyping. Genotype analysis using CoAIMs along with a Bayesian clustering method (STRUCTURE) is able to discern continental origins including Europe/Middle East (Caucasians), East Asia, Africa, Native America, and Oceania. In addition to determining continental ancestry for individuals without significant admixture, we applied CoAIMs to ascertain admixture proportions of individuals of self declared race. Conclusion/Significance CoAIMs can be used to efficiently and effectively determine continental admixture proportions in a sample set. The CoAIMs panel is a valuable resource for genetic researchers performing case-control genetic

  14. Information System for Societal Cost and Benefit Analysis of Vocational and Manpower Programs. Final Report.

    ERIC Educational Resources Information Center

    Arora, Mehar

    The study was directed toward developing a manual for establishing societal benefits and costs of vocational and manpower programs in Wisconsin. After first outlining the background of benefit-cost analysis, problems in establishing cost functions in education are presented along with some important cost concepts and uses of cost information in…

  15. What does an MRI scan cost?

    PubMed

    Young, David W

    2015-11-01

    Historically, hospital departments have computed the costs of individual tests or procedures using the ratio of cost to charges (RCC) method, which can produce inaccurate results. To determine a more accurate cost of a test or procedure, the activity-based costing (ABC) method must be used. Accurate cost calculations will ensure reliable information about the profitability of a hospital's DRGs. PMID:26685437

  16. The Social Costs of Ubiquitous Information: Consuming Information on Mobile Phones Is Associated with Lower Trust.

    PubMed

    Kushlev, Kostadin; Proulx, Jason D E

    2016-01-01

    In an age already saturated with information, the ongoing revolution in mobile computing has expanded the realm of immediate information access far beyond our homes and offices. In addition to changing where people can access information, mobile computing has changed what information people access-from finding specific directions to a restaurant to exploring nearby businesses when on the go. Does this ability to instantly gratify our information needs anytime and anywhere have any bearing on how much we trust those around us-from neighbors to strangers? Using data from a large nationally representative survey (World Values Survey: Wave 6), we found that the more people relied on their mobile phones for information, the less they trusted strangers, neighbors and people from other religions and nationalities. In contrast, obtaining information through any other method-including TV, radio, newspapers, and even the Internet more broadly-predicted higher trust in those groups. Mobile information had no bearing on how much people trusted close others, such as their family. Although causality cannot be inferred, these findings provide an intriguing first glimpse into the possible unforeseen costs of convenient information access for the social lubricant of society-our sense of trust in one another. PMID:27606707

  17. Cost-Benefit Analysis of Electronic Information: A Case Study.

    ERIC Educational Resources Information Center

    White, Gary W.; Crawford, Gregory A.

    1998-01-01

    Describes a study at Pennsylvania State University Harrisburg in which cost-benefit analysis (CBA) was used to examine the cost effectiveness of an electronic database. Concludes that librarians can use the results of CBA studies to justify budgets and acquisitions and to provide insight into the true costs of providing library services. (PEN)

  18. Learning the Structure of High-Dimensional Manifolds with Self-Organizing Maps for Accurate Information Extraction

    NASA Astrophysics Data System (ADS)

    Zhang, Lili

    This work aims to improve the capability of accurate information extraction from high-dimensional data, with a specific neural learning paradigm, the Self-Organizing Map (SOM). The SOM is an unsupervised learning algorithm that can faithfully sense the manifold structure and support supervised learning of relevant information from the data. Yet open problems regarding SOM learning exist. We focus on the following two issues. (1) Evaluation of topology preservation. Topology preservation is essential for SOMs in faithful representation of manifold structure. However, in reality, topology violations are not unusual, especially when the data have complicated structure. Measures capable of accurately quantifying and informatively expressing topology violations are lacking. One contribution of this work is a new measure, the Weighted Differential Topographic Function (WDTF), which differentiates an existing measure, the Topographic Function (TF), and incorporates detailed data distribution as an importance weighting of violations to distinguish severe violations from insignificant ones. Another contribution is an interactive visual tool, TopoView, which facilitates the visual inspection of violations on the SOM lattice. We show the effectiveness of the combined use of the WDTF and TopoView through a simple two-dimensional data set and two hyperspectral images. (2) Learning multiple latent variables from high-dimensional data. We use an existing two-layer SOM-hybrid supervised architecture, which captures the manifold structure in its SOM hidden layer, and then, uses its output layer to perform the supervised learning of latent variables. In the customary way, the output layer only uses the strongest output of the SOM neurons. This severely limits the learning capability. We allow multiple, k, strongest responses of the SOM neurons for the supervised learning. Moreover, the fact that different latent variables can be best learned with different values of k motivates a

  19. Accurate molecular dynamics and nuclear quantum effects at low cost by multiple steps in real and imaginary time: Using density functional theory to accelerate wavefunction methods.

    PubMed

    Kapil, V; VandeVondele, J; Ceriotti, M

    2016-02-01

    The development and implementation of increasingly accurate methods for electronic structure calculations mean that, for many atomistic simulation problems, treating light nuclei as classical particles is now one of the most serious approximations. Even though recent developments have significantly reduced the overhead for modeling the quantum nature of the nuclei, the cost is still prohibitive when combined with advanced electronic structure methods. Here we present how multiple time step integrators can be combined with ring-polymer contraction techniques (effectively, multiple time stepping in imaginary time) to reduce virtually to zero the overhead of modelling nuclear quantum effects, while describing inter-atomic forces at high levels of electronic structure theory. This is demonstrated for a combination of MP2 and semi-local DFT applied to the Zundel cation. The approach can be seamlessly combined with other methods to reduce the computational cost of path integral calculations, such as high-order factorizations of the Boltzmann operator or generalized Langevin equation thermostats. PMID:26851912

  20. 48 CFR 215.403-5 - Instructions for submission of cost or pricing data or information other than cost or pricing data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... submission of cost or pricing data or information other than cost or pricing data. 215.403-5 Section 215.403... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.403-5 Instructions for submission of cost or pricing data or information other than cost or pricing data. When...

  1. 14 CFR 151.24 - Procedures: Application; information on estimated project costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... estimated project costs. 151.24 Section 151.24 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Development Projects § 151.24 Procedures: Application; information on estimated project costs. (a) If any part of the estimated project costs consists of the value of donated land, labor, materials, or...

  2. 14 CFR 151.24 - Procedures: Application; information on estimated project costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... estimated project costs. 151.24 Section 151.24 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Development Projects § 151.24 Procedures: Application; information on estimated project costs. (a) If any part of the estimated project costs consists of the value of donated land, labor, materials, or...

  3. 14 CFR 151.24 - Procedures: Application; information on estimated project costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... estimated project costs. 151.24 Section 151.24 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Development Projects § 151.24 Procedures: Application; information on estimated project costs. (a) If any part of the estimated project costs consists of the value of donated land, labor, materials, or...

  4. 14 CFR 151.24 - Procedures: Application; information on estimated project costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... estimated project costs. 151.24 Section 151.24 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Development Projects § 151.24 Procedures: Application; information on estimated project costs. (a) If any part of the estimated project costs consists of the value of donated land, labor, materials, or...

  5. 14 CFR 151.24 - Procedures: Application; information on estimated project costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... estimated project costs. 151.24 Section 151.24 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Development Projects § 151.24 Procedures: Application; information on estimated project costs. (a) If any part of the estimated project costs consists of the value of donated land, labor, materials, or...

  6. An Analysis of Government Cost Estimates of Freedom of Information Act Compliance.

    ERIC Educational Resources Information Center

    Ullmann, John; List, Karen

    1985-01-01

    Examines the Reagan administration's use of cost as an argument for amending the Freedom of Information Act (FOIA). Finds two general problems with the argument: (1) incomplete, inconsistent, and inaccurate reporting of FOIA costs and (2) agency attitudes that affected the cost estimates they presented. (FL)

  7. Evaluation of the Field Test of Project Information Packages: Volume III--Resource Cost Analysis.

    ERIC Educational Resources Information Center

    Al-Salam, Nabeel; And Others

    The third of three volumes evaluating the first year field test of the Project Information Packages (PIPs) provides a cost analysis study as a key element in the total evaluation. The resource approach to cost analysis is explained and the specific resource methodology used in the main cost analysis of the 19 PIP field-test projects detailed. The…

  8. Digital Avionics Information System Preliminary Life-Cycle-Cost Analysis. Final Report (November 1974-May 1975).

    ERIC Educational Resources Information Center

    Pruitt, Gary K.; Dieterly, Duncan L.

    The results of a study to evaluate the potential life-cycle costs and cost savings that could be realized by applying the Digital Avionics Information System (DAIS) concept to future avionic systems were presented. The tasks evaluated included selection of program elements for costing, selection of DAIS installation potential, definition of a…

  9. Integrated Undergraduate Management Education: An Informal Benefit/Cost Analysis

    ERIC Educational Resources Information Center

    Casey, William L., Jr.

    2005-01-01

    This paper seeks to contribute to the literature of management education by evaluating assessment data on Babson College's integrated undergraduate management core program (IMC). Transitions from functionally isolated curricula to more integrated alternatives involve both benefits and costs, accruing to faculty, students and sponsoring…

  10. Thermodynamic cost of computation, algorithmic complexity and the information metric

    NASA Technical Reports Server (NTRS)

    Zurek, W. H.

    1989-01-01

    Algorithmic complexity is discussed as a computational counterpart to the second law of thermodynamics. It is shown that algorithmic complexity, which is a measure of randomness, sets limits on the thermodynamic cost of computations and casts a new light on the limitations of Maxwell's demon. Algorithmic complexity can also be used to define distance between binary strings.

  11. 48 CFR 215.403-3 - Requiring information other than cost or pricing data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Requiring information other than cost or pricing data. 215.403-3 Section 215.403-3 Federal Acquisition Regulations System... CONTRACTING BY NEGOTIATION Contract Pricing 215.403-3 Requiring information other than cost or pricing...

  12. 48 CFR 215.403-3 - Requiring information other than cost or pricing data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Requiring information other than cost or pricing data. 215.403-3 Section 215.403-3 Federal Acquisition Regulations System... CONTRACTING BY NEGOTIATION Contract Pricing 215.403-3 Requiring information other than cost or pricing...

  13. 48 CFR 215.403-3 - Requiring information other than cost or pricing data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Requiring information other than cost or pricing data. 215.403-3 Section 215.403-3 Federal Acquisition Regulations System... CONTRACTING BY NEGOTIATION Contract Pricing 215.403-3 Requiring information other than cost or pricing...

  14. 47 CFR 25.111 - Additional information and ITU cost recovery.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Additional information and ITU cost recovery. 25.111 Section 25.111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER....111 Additional information and ITU cost recovery. (a) The Commission may request from any party at...

  15. 40 CFR 2.311 - Special rules governing certain information obtained under the Motor Vehicle Information and Cost...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Special rules governing certain information obtained under the Motor Vehicle Information and Cost Savings Act. 2.311 Section 2.311 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION Confidentiality of...

  16. Risk informed resource allocation policy: safety can save costs.

    PubMed

    Pasman, H J

    2000-01-01

    During economic doldrums, decision making on investments for safety is even more difficult than it already is when funds are abundant. This paper attempts to offer some guidance. After stating the present challenge to prevention of losses in the process industries, the systematic approach of quantified risk assessment is briefly reviewed and improvements in the methodology are mentioned. In addition, attention is given to the use of a risk matrix to survey a plant and to derive a plan of action. Subsequently, the reduction of risk is reviewed. Measures for prevention, protection, and mitigation are discussed. The organization of safety has become at least as important as technical safety of equipment and standards. It is reflected in the introduction of a safety management system. Furthermore, the design process in a pro-active approach is described and the concept of inherent safety is briefly addressed. The concept of Layer of Protection Analysis is explained and also the reason why it is relevant to provide a cost-benefit analysis. Finally, after comments regarding the cost of accidents, the basics of costing and profitability are summarized and a way is suggested to apply this approach to risk-reducing measures. An example is provided on how a selection can be made from a number of alternatives. PMID:10677670

  17. Cost Accounting for Decision Makers.

    ERIC Educational Resources Information Center

    Kaneklides, Ann L.

    1985-01-01

    Underscores the importance of informed decision making through accurate anticipation of cost incurrence in light of changing economic and environmental conditions. Explains the concepts of cost accounting, full allocation of costs, the selection of an allocation base, the allocation of indirect costs, depreciation, and implications for community…

  18. The hidden cost of information in collective foraging

    PubMed Central

    Dechaume-Moncharmont, François-Xavier; Dornhaus, Anna; Houston, Alasdair I; McNamara, John M; Collins, Edmund J; Franks, Nigel R

    2005-01-01

    Many animals nest or roost colonially. At the start of a potential foraging period, they may set out independently or await information from returning foragers. When should such individuals act independently and when should they wait for information? In a social insect colony, for example, information transfer may greatly increase a recruit's probability of finding food, and it is commonly assumed that this will always increase the colony's net energy gain. We test this assumption with a mathematical model. Energy gain by a colony is a function both of the probability of finding food sources and of the duration of their availability. A key factor is the ratio of pro-active foragers to re-active foragers. When leaving the nest, pro-active foragers search for food independently, whereas re-active foragers rely on information from successful foragers to find food. Under certain conditions, the optimum strategy is totally independent (pro-active) foraging because potentially valuable information that re-active foragers may gain from successful foragers is not worth waiting for. This counter-intuitive outcome is remarkably robust over a wide range of parameters. It occurs because food sources are only available for a limited period. Our study emphasizes the importance of time constraints and the analysis of dynamics, not just steady states, to understand social insect foraging. PMID:16087424

  19. Low-cost information distribution - New directions for technology developments

    NASA Technical Reports Server (NTRS)

    Catoe, C. E.

    1978-01-01

    The use of space satellites for data storage and retrieval is discussed with respect to short-term (1978-1985) and long-term (1985-2000) developments. The present structure, where access to satellite-transmitted data is controlled largely by the Federal Government for its own use, will be gradually replaced by a continually expanding user-community with a broadening scope of needs. Technological improvements in satellite-communication and data-processing will drive down the cost of both transmitting and receiving hardware, making such hardware available to more and more people. By the closing years of the century, personal, direct satellite communication should be available to every American household, providing video, printed, and archivable data over a wide range of subjects, from bank statements to medical records.

  20. A Trial of Nursing Cost Accounting using Nursing Practice Data on a Hospital Information System.

    PubMed

    Miyahira, Akiko; Tada, Kazuko; Ishima, Masatoshi; Nagao, Hidenori; Miyamoto, Tadashi; Nakagawa, Yoshiaki; Takemura, Tadamasa

    2015-01-01

    Hospital administration is very important and many hospitals carry out activity-based costing under comprehensive medicine. However, nursing cost is unclear, because nursing practice is expanding both quantitatively and qualitatively and it is difficult to grasp all nursing practices, and nursing cost is calculated in many cases comprehensively. On the other hand, a nursing information system (NIS) is implemented in many hospitals in Japan and we are beginning to get nursing practical data. In this paper, we propose a nursing cost accounting model and we simulate a cost by nursing contribution using NIS data. PMID:26262246

  1. Judgements about the Value and Cost of Human Factors Information in Design.

    ERIC Educational Resources Information Center

    Burns, Catherine M.; Vicente, Kim J.

    1996-01-01

    Describes an empirical evaluation that investigated the criteria by which designers of human-machine systems evaluate design information. Professional designers of nuclear power plant control rooms rated hypothetical information search questions in terms of relevance, importance, cost, and effort based on Rouse's model of information search…

  2. 77 FR 75163 - Federal Acquisition Regulation; Information Collection; Contract Funding-Limitation of Costs/Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... notice for an extension to this information collection published in the Federal Register at 74 FR 56639... Regulation; Information Collection; Contract Funding--Limitation of Costs/Funds AGENCIES: Department of...: Submit comments identified by Information Collection 9000- 0074, Contract Funding--Limitation of...

  3. Dementia severity and the longitudinal costs of informal care in the Cache County Population

    PubMed Central

    Rattinger, Gail B.; Schwartz, Sarah; Mullins, C. Daniel; Corcoran, Chris; Zuckerman, Ilene H.; Sanders, Chelsea; Norton, Maria C.; Fauth, Elizabeth B.; Leoutsakos, Jeannie-Marie S.; Lyketsos, Constantine G.; Tschanz, JoAnn T.

    2015-01-01

    Background Dementia costs are critical for influencing healthcare policy, but limited longitudinal information exists. We examined longitudinal informal care costs of dementia in a population-based sample. Methods Data from the Cache County Study included dementia onset, duration and severity assessed by the Mini Mental State Examination (MMSE), Clinical Dementia Rating Scale (CDR) and Neuropsychiatric Inventory (NPI). Informal cost of daily care (COC) was estimated based on median Utah wages. Mixed models estimated the relationship between severity and longitudinal COC in separate models for MMSE and CDR. Results 287 subjects [53% female, mean (sd) age was 82.3(5.9) years] participated. Overall COC increased by 18%/year. COC was 6% lower per MMSE-point increase and compared with very mild dementia, COC increased over 2-fold for mild, 5-fold for moderate and 6-fold for severe dementia on the CDR. Conclusions Greater dementia severity predicted higher costs. Disease management strategies addressing dementia progression may curb costs. PMID:25614127

  4. Waste Management Facilities cost information for mixed low-level waste. Revision 1

    SciTech Connect

    Shropshire, D.; Sherick, M.; Biadgi, C.

    1995-06-01

    This report contains preconceptual designs and planning level life-cycle cost estimates for managing mixed low-level waste. The report`s information on treatment, storage, and disposal modules can be integrated to develop total life-cycle costs for various waste management options. A procedure to guide the US Department of Energy and its contractor personnel in the use of cost estimation data is also summarized in this report.

  5. Memorandum: "Cost Sharing" for the Dissemination of Government Information in Electronic Formats.

    ERIC Educational Resources Information Center

    Zagami, Anthony J.

    1991-01-01

    It is not legally permissible for depository libraries to impose user fees upon library patrons who want government information which is available in electronic format. Publishing federal agency is responsible for costs of furnishing access to the database, and Government Printing Office is obligated to pay the costs of conveying that information…

  6. The neglected topic: presentation of cost information in patient decision AIDS.

    PubMed

    Blumenthal-Barby, J S; Robinson, Emily; Cantor, Scott B; Naik, Aanand D; Russell, Heidi Voelker; Volk, Robert J

    2015-05-01

    Costs are an important component of patients' decision making, but a comparatively underemphasized aspect of formal shared decision making. We hypothesized that decision aids also avoid discussion of costs, despite their being tools designed to facilitate shared decision making about patient-centered outcomes. We sought to define the frequency of cost-related information and identify the common modes of presenting cost and cost-related information in the 290 decision aids catalogued in the Ottawa Hospital Research Institute's Decision Aid Library Inventory (DALI) system. We found that 56% (n = 161) of the decision aids mentioned cost in some way, but only 13% (n = 37) gave a specific price or range of prices. We identified 9 different ways in which cost was mentioned. The most common approach was as a "pro" of one of the treatment options (e.g., "you avoid the cost of medication"). Of the 37 decision aids that gave specific prices or ranges of prices for treatment options, only 2 were about surgery decisions despite the fact that surgery decision aids were the most common. Our findings suggest that presentation of cost information in decision aids is highly variable. Evidence-based guidelines should be developed by the International Patient Decision Aid Standards (IPDAS) Collaboration. PMID:25583552

  7. Relationship between patient dependence and direct medical-, social-, indirect-, and informal-care costs in Spain

    PubMed Central

    Darbà, Josep; Kaskens, Lisette

    2015-01-01

    Objective The objectives of this analysis were to examine how patients’ dependence on others relates to costs of care and explore the incremental effects of patient dependence measured by the Dependence Scale on costs for patients with Alzheimer’s disease (AD) in Spain. Methods The Co-Dependence in Alzheimer’s Disease study is an 18 multicenter, cross-sectional, observational study among patients with AD according to the clinical dementia rating score and their caregivers in Spain. This study also gathered data on resource utilization for medical care, social care, caregiver productivity losses, and informal caregiver time reported in the Resource Utilization in Dementia Lite instrument and a complementary questionnaire. The data of 343 patients and their caregivers were collected through the completion of a clinical report form during one visit/assessment at an outpatient center or hospital, where all instruments were administered. The data collected (in addition to clinical measures) also included sociodemographic data concerning the patients and their caregivers. Cost analysis was based on resource use for medical care, social care, caregiver productivity losses, and informal caregiver time reported in the Resource Utilization in Dementia Lite instrument and a complementary questionnaire. Resource unit costs were applied to value direct medical-, social-, and indirect-care costs. A replacement cost method was used to value informal care. Patient dependence on others was measured using the Dependence Scale, and the Cumulative Index Rating Scale was administered to the patient to assess multi-morbidity. Multivariate regression analysis was used to model the effects of dependence and other sociodemographic and clinical variables on cost of care. Results The mean (standard deviation) costs per patient over 6 months for direct medical-, social-, indirect-, and informal-care costs were estimated at €1,028.10 (€1,655.00), €843.80 (€2,684.80), €464.20 (

  8. The Relationship between Return on Profitability and Costs of Outsourcing Information Technology Technical Support

    ERIC Educational Resources Information Center

    Odion, Segun

    2011-01-01

    The purpose of this quantitative correlational research study was to examine the relationship between costs of operation and total return on profitability of outsourcing information technology technical support in a two-year period of outsourcing operations. United States of America list of Fortune 1000 companies' chief information officers…

  9. Improving Memory after Interruption: Exploiting Soft Constraints and Manipulating Information Access Cost

    ERIC Educational Resources Information Center

    Morgan, Phillip L.; Patrick, John; Waldron, Samuel M.; King, Sophia L.; Patrick, Tanya

    2009-01-01

    Forgetting what one was doing prior to interruption is an everyday problem. The recent soft constraints hypothesis (Gray, Sims, Fu, & Schoelles, 2006) emphasizes the strategic adaptation of information processing strategy to the task environment. It predicts that increasing information access cost (IAC: the time, and physical and mental effort…

  10. Financial and Cost Management for Libraries and Information Services. Second Edition.

    ERIC Educational Resources Information Center

    Roberts, Stephen A.

    This book highlights the importance of good financial and cost management in libraries and information centers to make best use of available resources, and illustrates how to maintain user services. The book applies current research and theory of financial management techniques to situations faced in libraries and information services. Eight…

  11. Accurate 3D rigid-body target motion and structure estimation by using GMTI/HRR with template information

    NASA Astrophysics Data System (ADS)

    Wu, Shunguang; Hong, Lang

    2008-04-01

    A framework of simultaneously estimating the motion and structure parameters of a 3D object by using high range resolution (HRR) and ground moving target indicator (GMTI) measurements with template information is given. By decoupling the motion and structure information and employing rigid-body constraints, we have developed the kinematic and measurement equations of the problem. Since the kinematic system is unobservable by using only one scan HRR and GMTI measurements, we designed an architecture to run the motion and structure filters in parallel by using multi-scan measurements. Moreover, to improve the estimation accuracy in large noise and/or false alarm environments, an interacting multi-template joint tracking (IMTJT) algorithm is proposed. Simulation results have shown that the averaged root mean square errors for both motion and structure state vectors have been significantly reduced by using the template information.

  12. The role of cognitive switching in head-up displays. [to determine pilot ability to accurately extract information from either of two sources

    NASA Technical Reports Server (NTRS)

    Fischer, E.

    1979-01-01

    The pilot's ability to accurately extract information from either one or both of two superimposed sources of information was determined. Static, aerial, color 35 mm slides of external runway environments and slides of corresponding static head-up display (HUD) symbology were used as the sources. A three channel tachistoscope was utilized to show either the HUD alone, the scene alone, or the two slides superimposed. Cognitive performance of the pilots was assessed by determining the percentage of correct answers given to two HUD related questions, two scene related questions, or one HUD and one scene related question.

  13. Estimating costs of traffic crashes and crime: tools for informed decision making.

    PubMed

    Streff, F M; Molnar, L J; Cohen, M A; Miller, T R; Rossman, S B

    1992-01-01

    Traffic crashes and crime both impose significant economic and social burdens through injury and loss of life, as well as property damage and loss. Efforts to reduce crashes and crime often result in competing demands on limited public resources. Comparable and up-to-date cost data on crashes and crime contribute to informed decisions about allocation of these resources in important ways. As a first step, cost data provide information about the magnitude of the problems of crashes and crime by allowing us to estimate associated dollar losses to society. More importantly, cost data on crashes and crime are essential to evaluating costs and benefits of various policy alternatives that compete for resources. This paper presents the first comparable comprehensive cost estimates for crashes and crime and applies them to crash and crime incidence data for Michigan to generate dollar losses for the state. An example illustrates how cost estimates can be used to evaluate costs and benefits of crash-reduction and crime-reduction policies in making resource allocation decisions. Traffic crash and selected index crime incidence data from the calendar year 1988 were obtained from the Michigan State Police. Costs for crashes and index crimes were generated and applied to incidence data to estimate dollar losses from crashes and index crimes for the state of Michigan. In 1988, index crimes in Michigan resulted in $0.8 billion in monetary costs and $2.4 billion in total monetary and nonmonetary quality-of-life costs (using the willingness-to-pay approach). Traffic crashes in Michigan resulted in $2.3 billion in monetary costs and $7.1 billion in total monetary and nonmonetary quality-of-life costs, nearly three times the costs of index crimes. Based on dollar losses to the state, the magnitude of the problem of traffic crashes clearly exceeded that of index crimes in Michigan in 1988. From a policy perspective, summing the total dollar losses from crashes or crime is of less

  14. Accurate prediction of protein secondary structure and solvent accessibility by consensus combiners of sequence and structure information

    PubMed Central

    Pollastri, Gianluca; Martin, Alberto JM; Mooney, Catherine; Vullo, Alessandro

    2007-01-01

    Background Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio case but also when homology information to known structures is available. Structural properties are also routinely used in protein analysis even when homology is available, largely because homology modelling is lower throughput than, say, secondary structure prediction. Nonetheless, predictors of secondary structure and solvent accessibility are virtually always ab initio. Results Here we develop high-throughput machine learning systems for the prediction of protein secondary structure and solvent accessibility that exploit homology to proteins of known structure, where available, in the form of simple structural frequency profiles extracted from sets of PDB templates. We compare these systems to their state-of-the-art ab initio counterparts, and with a number of baselines in which secondary structures and solvent accessibilities are extracted directly from the templates. We show that structural information from templates greatly improves secondary structure and solvent accessibility prediction quality, and that, on average, the systems significantly enrich the information contained in the templates. For sequence similarity exceeding 30%, secondary structure prediction quality is approximately 90%, close to its theoretical maximum, and 2-class solvent accessibility roughly 85%. Gains are robust with respect to template selection noise, and significant for marginal sequence similarity and for short alignments, supporting the claim that these improved predictions may prove beneficial beyond the case in which clear homology is available. Conclusion The predictive system are publicly available at the address . PMID:17570843

  15. Multiplying probe for accurate power measurements on an RF driven atmospheric pressure plasma jet applied to the COST reference microplasma jet

    NASA Astrophysics Data System (ADS)

    Beijer, P. A. C.; Sobota, A.; van Veldhuizen, E. M.; Kroesen, G. M. W.

    2016-03-01

    In this paper a new multiplying probe for measuring the power dissipated in a miniature capacitively coupled, RF driven, atmospheric pressure plasma jet (μAPPJ—COST Reference Microplasma Jet—COST RMJ) is presented. The approach aims for substantially higher accuracy than provided by traditionally applied methods using bi-directional power meters or commercially available voltage and current probes in conjunction with digitizing oscilloscopes. The probe is placed on a miniature PCB and designed to minimize losses, influence of unknown elements, crosstalk and variations in temperature. The probe is designed to measure powers of the order of magnitude of 0.1-10 W. It is estimated that it measures power with less than 2% deviation from the real value in the tested power range. The design was applied to measure power dissipated in COST-RMJ running in helium with a small addition of oxygen.

  16. Cost reduction and minimization of land based on an accurate determination of fault current distribution in shield wires and grounding systems

    SciTech Connect

    Daily, W.K. ); Dawalibi, F. )

    1993-01-01

    Careful analysis of Fault Current Distribution in neutral metallic paths, Power System Protection requirements and Ground Potential Rise (GPR) evaluations were carried out at FPL's Lauderdale Power Plant and associated switchyard. These studies resulted in substantial cost savings and land utilization minimization for the power system expansions at Lauderdale Plant by confirming that the in-situ expansion and reconfiguration aimed at constructing two electrically independent substations sharing the same site and grounding system is a sound economical alternative to the construction of a new substation and associated significant site preparation and construction costs. This paper describes the methodology used to conduct this study.

  17. Short-Term Medical Costs of a VHA Health Information Exchange: A CHEERS-Compliant Article

    PubMed Central

    French, Dustin D.; Dixon, Brian E.; Perkins, Susan M.; Myers, Laura J.; Weiner, Michael; Zillich, Allan J.; Haggstrom, David A.

    2016-01-01

    Abstract The Virtual Lifetime Electronic Record (VLER) Health program provides the Veterans Health Administration (VHA) a framework whereby VHA providers can access the veterans’ electronic health record information to coordinate healthcare across multiple sites of care. As an early adopter of VLER, the Indianapolis VHA and Regenstrief Institute implemented a regional demonstration program involving bi-directional health information exchange (HIE) between VHA and non-VHA providers. The aim of the study is to determine whether implementation of VLER HIE reduces 1 year VHA medical costs. A cohort evaluation with a concurrent control group compared VHA healthcare costs using propensity score adjustment. A CHEERs compliant checklist was used to conduct the cost evaluation. Patients were enrolled in the VLER program onsite at the Indianapolis VHA in outpatient clinics or through the release-of-information office. VHA cost data (in 2014 dollars) were obtained for both enrolled and nonenrolled (control) patients for 1 year prior to, and 1 year after, the index date of patient enrollment. There were 6104 patients enrolled in VLER and 45,700 patients in the control group. The annual adjusted total cost difference per patient was associated with a higher cost for VLER enrollees $1152 (95% CI: $807–1433) (P < 0.01) (in 2014 dollars) than VLER nonenrollees. Short-term evaluation of this demonstration project did not show immediate reductions in healthcare cost as might be expected if HIE decreased redundant medical tests and treatments. Cost reductions from shared health information may be realized with longer time horizons. PMID:26765453

  18. Interim report: Waste management facilities cost information for mixed low-level waste

    SciTech Connect

    Feizollahi, F.; Shropshire, D.

    1994-03-01

    This report contains preconceptual designs and planning level life-cycle cost estimates for treating alpha and nonalpha mixed low-level radioactive waste. This report contains information on twenty-seven treatment, storage, and disposal modules that can be integrated to develop total life cycle costs for various waste management options. A procedure to guide the US Department of Energy and its contractor personnel in the use of estimating data is also summarized in this report.

  19. Considerations in developing geographic informations systems based on low-cost digital image processing

    NASA Technical Reports Server (NTRS)

    Henderson, F. M.; Dobson, M. W.

    1981-01-01

    The potential of digital image processing systems costing $20,000 or less for geographic information systems is assessed with the emphasis on the volume of data to be handled, the commercial hardware systems available, and the basic software for: (1) data entry, conversion and digitization; (2) georeferencing and geometric correction; (3) data structuring; (4) editing and updating; (5) analysis and retrieval; (6) output drivers; and (7) data management. Costs must also be considered as tangible and intangible factors.

  20. Assignment of Calibration Information to Deeper Phylogenetic Nodes is More Effective in Obtaining Precise and Accurate Divergence Time Estimates.

    PubMed

    Mello, Beatriz; Schrago, Carlos G

    2014-01-01

    Divergence time estimation has become an essential tool for understanding macroevolutionary events. Molecular dating aims to obtain reliable inferences, which, within a statistical framework, means jointly increasing the accuracy and precision of estimates. Bayesian dating methods exhibit the propriety of a linear relationship between uncertainty and estimated divergence dates. This relationship occurs even if the number of sites approaches infinity and places a limit on the maximum precision of node ages. However, how the placement of calibration information may affect the precision of divergence time estimates remains an open question. In this study, relying on simulated and empirical data, we investigated how the location of calibration within a phylogeny affects the accuracy and precision of time estimates. We found that calibration priors set at median and deep phylogenetic nodes were associated with higher precision values compared to analyses involving calibration at the shallowest node. The results were independent of the tree symmetry. An empirical mammalian dataset produced results that were consistent with those generated by the simulated sequences. Assigning time information to the deeper nodes of a tree is crucial to guarantee the accuracy and precision of divergence times. This finding highlights the importance of the appropriate choice of outgroups in molecular dating. PMID:24855333

  1. The Complex Trial Protocol (CTP): a new, countermeasure-resistant, accurate, P300-based method for detection of concealed information.

    PubMed

    Rosenfeld, J Peter; Labkovsky, Elena; Winograd, Michael; Lui, Ming A; Vandenboom, Catherine; Chedid, Erica

    2008-11-01

    A new P300-based concealed information test is described. A rare probe or frequent irrelevant stimulus appears in the same trial in which a target or nontarget later appears. One response follows the first stimulus and uses the same button press regardless of stimulus type. A later second stimulus then appears: target or nontarget. The subject presses one button for a target, another for a nontarget. A P300 to the first stimulus indicates probe recognition. One group was tested in 3 weeks for denied recognition of familiar information. Weeks 1 and 3 were guilty conditions; Week 2 was a countermeasure (CM) condition. The probe-irrelevant differences were significant in all weeks, and percent hits were >90%. Attempted CM use was detectable via elevated reaction time to the first stimulus. In a replication, results were similar. False positive rates for both studies varied from 0 to .08, yielding J. B. Grier (1971) A' values from .9 to 1.0. PMID:18823418

  2. 30 CFR 251.13 - Reimbursement for the costs of reproducing data and information and certain processing costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... not include cost of data acquisition): (1) If, at the request of the Regional Director, you processed... reimbursement, you must identify reproduction and processing costs separately from acquisition costs. (d) MMS will not reimburse you or a third party for data acquisition costs or for the costs of analyzing...

  3. Whatever the cost? Information integration in memory-based inferences depends on cognitive effort.

    PubMed

    Hilbig, Benjamin E; Michalkiewicz, Martha; Castela, Marta; Pohl, Rüdiger F; Erdfelder, Edgar

    2015-05-01

    One of the most prominent models of probabilistic inferences from memory is the simple recognition heuristic (RH). The RH theory assumes that judgments are based on recognition in isolation, such that other information is ignored. However, some prior research has shown that available knowledge is not generally ignored. In line with the notion of adaptive strategy selection--and, thus, a trade-off between accuracy and effort--we hypothesized that information integration crucially depends on how easily accessible information beyond recognition is, how much confidence decision makers have in this information, and how (cognitively) costly it is to acquire it. In three experiments, we thus manipulated (a) the availability of information beyond recognition, (b) the subjective usefulness of this information, and (c) the cognitive costs associated with acquiring this information. In line with the predictions, we found that RH use decreased substantially, the more easily and confidently information beyond recognition could be integrated, and increased substantially with increasing cognitive costs. PMID:25504054

  4. Cost and burden of informal caregiving of dependent older people in a rural Indian community

    PubMed Central

    2014-01-01

    Background Lack of state supported care services begets the informal caregiving by family members as the mainstay of care provided to the dependent older people in many Low and Middle Income Countries (LMICs), including India. Little is known about the time spent on caregiving, its cost and the burden experienced by these informal caregivers. We aimed to estimate the costs of informal caregiving and to evaluate the nature as well as correlates of caregivers’ burden in a rural Indian community. Methods We assessed 1000 people aged above 65 years, among whom 85 were dependent. We assessed their socioeconomic profiles, disability, health status and health expenditures. Their caregivers’ socio-demographic profiles, mental health, and the time spent on caregiving were assessed using standard instruments. Caregiver’s burden was evaluated using Zarit Burden Scale. We valued the annual informal caregiving costs using proxy good method. We employed appropriate non-parametric multivariate statistics to evaluate the correlates of caregivers’ burden. Results Average time spent on informal caregiving was 38.6 (95% CI 35.3-41.9) hours/week. Estimated annual cost of informal caregiving using proxy good method was 119,210 US$ in this rural community. Mean total score of Zarit burden scale, measuring caregivers’ burden, was 17.9 (95% CI 15.6-20.2). Prevalence of depression among the caregivers was 10.6% (95% CI 4.1-17.1%). Cerebrovascular disease, Parkinson’s disease, higher disability, insomnia and incontinence of the dependent older people as well as the time spent on helping Activities of Daily Living and on supervision increased caregiver's burden significantly. Conclusions Cost and burden of informal caregiving are high in this rural Indian community. Many correlates of burden, experienced by caregivers, are modifiable. We discuss potential strategies to reduce this burden in LMICs. Need for support to informal caregivers and for management of dependent older

  5. The Lunar Laser Ranging Experiment: Accurate ranges have given a large improvement in the lunar orbit and new selenophysical information.

    PubMed

    Bender, P L; Currie, D G; Poultney, S K; Alley, C O; Dicke, R H; Wilkinson, D T; Eckhardt, D H; Faller, J E; Kaula, W M; Mulholland, J D; Plotkin, H H; Silverberg, E C; Williams, J G

    1973-10-19

    The lunar ranging measurements now being made at the McDonald Observatory have an accuracy of 1 nsec in round-trip travel time. This corresponds to 15 cm in the one-way distance. The use of lasers with pulse-lengths of less than 1 nsec is expected to give an accuracy of 2 to 3 cm in the next few years. A new station is under construction in Hawaii, and additional stations in other countries are either in operation or under development. It is hoped that these stations will form the basis for a worldwide network to determine polar motion and earth rotation on a regular basis, and will assist in providing information about movement of the tectonic plates making up the earth's surface. Several mobile lunar ranging stations with telescopes having diameters of 1.0 m or less could, in the future, greatly extend the information obtainable about motions within and between the tectonic plates. The data obtained so far by the McDonald Observatory have been used to generate a new lunar ephemeris based on direct numerical integration of the equations of motion for the moon and planets. With this ephemeris, the range to the three Apollo retro-reflectors can be fit to an accuracy of 5 m by adjusting the differences in moments of inertia of the moon about its principal axes, the selenocentric coordinates of the reflectors, and the McDonald longitude. The accuracy of fitting the results is limited currently by errors of the order of an arc second in the angular orientation of the moon, as derived from the best available theory of how the moon rotates in response to the torques acting on it. Both a new calculation of the moon's orientation as a function of time based on direct numerical integration of the torque equations and a new analytic theory of the moon's orientation are expected to be available soon, and to improve considerably the accuracy of fitting the data. The accuracy already achieved routinely in lunar laser ranging represents a hundredfold improvement over any

  6. American Academy of Orthopaedic Surgeons Disclosure Policy Fails to Accurately Inform Its Members of Potential Conflicts of Interest.

    PubMed

    Tanzer, Dylan; Smith, Karen; Tanzer, Michael

    2015-07-01

    The American Academy of Orthopaedic Surgeons (AAOS) disclosure policy is designed to ensure that members involved in education or policy development remain free of outside influence. Although mandatory for these members, it is voluntary for the rest of the AAOS membership. To determine surgeon compliance with disclosure policy, we conducted a study in which we compared surgeon-consultants' disclosures as posted on 6 major orthopedic companies' websites in 2011 with those surgeons' disclosures as listed in AAOS disclosure program records. We found that 549 AAOS members were identified by at least 1 company as having received consulting payments. Overall, 44% of AAOS members did not comply with disclosure policy, or their information was not available on the AAOS website (range, 37%-61%). This study demonstrated that AAOS's policy of mandatory disclosure for select members and voluntary disclosure for all other members is ineffective. The AAOS disclosure program and the potential consequences of noncompliance need to be reevaluated by the organization if it wants its program to succeed. PMID:26161764

  7. Cost recovery in geographic information systems and conflicts with copyright law

    NASA Astrophysics Data System (ADS)

    Roberts, Jon L.

    1993-10-01

    The ability to recover cost by the sale of geographic information is dependent upon the ownership of the copyright in and to that information. The ownership of the copyright turns upon whether one entity is an employee of the other or whether the copyrightable work falls within certain statutorily defined categories in the copyright law. Absent the specific requirements being fulfilled the ownership of the data may not be exactly as the parties expect.

  8. A study of the relative effectiveness and cost of computerized information retrieval in the interactive mode

    NASA Technical Reports Server (NTRS)

    Smetana, F. O.; Furniss, M. A.; Potter, T. R.

    1974-01-01

    Results of a number of experiments to illuminate the relative effectiveness and costs of computerized information retrieval in the interactive mode are reported. It was found that for equal time spent in preparing the search strategy, the batch and interactive modes gave approximately equal recall and relevance. The interactive mode however encourages the searcher to devote more time to the task and therefore usually yields improved output. Engineering costs as a result are higher in this mode. Estimates of associated hardware costs also indicate that operation in this mode is more expensive. Skilled RECON users like the rapid feedback and additional features offered by this mode if they are not constrained by considerations of cost.

  9. Costs of the New Information Technologies in Education: Characteristics and Problems of Measurement.

    ERIC Educational Resources Information Center

    Eicher, J. C.

    Although an increasing number of theoretical analyses and evaluations have been conducted since microcomputer technology was developed and introduced into classrooms, few new studies have been undertaken on the costs of these new information technologies (NIT). This report focuses on the methodological problems that must be solved in order to…

  10. 19 CFR 10.21 - Updating cost data and other information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Updating cost data and other information. 10.21 Section 10.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Assembled Abroad with United...

  11. 19 CFR 10.21 - Updating cost data and other information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Updating cost data and other information. 10.21 Section 10.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Assembled Abroad with United...

  12. 19 CFR 10.21 - Updating cost data and other information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Updating cost data and other information. 10.21 Section 10.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Assembled Abroad with United...

  13. 19 CFR 10.21 - Updating cost data and other information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Updating cost data and other information. 10.21 Section 10.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY ARTICLES CONDITIONALLY FREE, SUBJECT TO A REDUCED RATE, ETC. General Provisions Articles Assembled Abroad with United...

  14. Cost Recovery in Pricing and Capacity Decisions for Automated Information Systems. Final Report.

    ERIC Educational Resources Information Center

    Dei Rossi, James A.

    This paper examines the cost-benefit implications of alternative pricing and capacity investment decisions for automated scientific and technical information retrieval systems. Two typical systems are examined and numerical examples presented. In the first system, search requests are entered on-site. The show how setting price to maximize net…

  15. Cost Reduction in University Information Systems: The Opportunities and the Pitfalls.

    ERIC Educational Resources Information Center

    Aherne, Michael P.; Navarro, Joseph J.

    Computerized information systems are often installed to reduce costs of: (1) system maintenance by requiring fewer man-hours, (2) system enhancement by requiring less manpower, (3) mechanical efficiency by doing more per clock-hour of time, (4) personnel by substituting machine expenditures, (5) supplies and support services by using microforms or…

  16. It's a jungle out there: strategies for controlling information systems costs.

    PubMed

    Seiter, T J; Pagnotta, R R; Ciotti, V G

    1994-06-01

    This article discusses four major areas where healthcare financial managers can reconcile the conflicting goals their healthcare organizations face: keeping up with the latest in technology while at the same time constantly striving to reduce healthcare information systems costs. PMID:10146031

  17. Digital Avionics Information System (DAIS): Impact of DAIS Concept on Life Cycle Cost. Final Report.

    ERIC Educational Resources Information Center

    Goclowski, John C.; And Others

    Designed to identify and quantify the potential impacts of the Digital Avionics Information System (DAIS) on weapon system personnel requirements and life cycle cost (LCC), this study postulated a typical close-air-support (CAS) mission avionics suite to serve as a basis for comparing present day and DAIS configuration specifications. The purpose…

  18. Metabolic cost of neuronal information in an empirical stimulus-response model.

    PubMed

    Kostal, Lubomir; Lansky, Petr; McDonnell, Mark D

    2013-06-01

    The limits on maximum information that can be transferred by single neurons may help us to understand how sensory and other information is being processed in the brain. According to the efficient-coding hypothesis (Barlow, Sensory Comunication, MIT press, Cambridge, 1961), neurons are adapted to the statistical properties of the signals to which they are exposed. In this paper we employ methods of information theory to calculate, both exactly (numerically) and approximately, the ultimate limits on reliable information transmission for an empirical neuronal model. We couple information transfer with the metabolic cost of neuronal activity and determine the optimal information-to-metabolic cost ratios. We find that the optimal input distribution is discrete with only six points of support, both with and without a metabolic constraint. However, we also find that many different input distributions achieve mutual information close to capacity, which implies that the precise structure of the capacity-achieving input is of lesser importance than the value of capacity. PMID:23467914

  19. An Accurate and Fault-Tolerant Target Positioning System for Buildings Using Laser Rangefinders and Low-Cost MEMS-Based MARG Sensors.

    PubMed

    Zhao, Lin; Guan, Dongxue; Landry, René; Cheng, Jianhua; Sydorenko, Kostyantyn

    2015-01-01

    Target positioning systems based on MEMS gyros and laser rangefinders (LRs) have extensive prospects due to their advantages of low cost, small size and easy realization. The target positioning accuracy is mainly determined by the LR's attitude derived by the gyros. However, the attitude error is large due to the inherent noises from isolated MEMS gyros. In this paper, both accelerometer/magnetometer and LR attitude aiding systems are introduced to aid MEMS gyros. A no-reset Federated Kalman Filter (FKF) is employed, which consists of two local Kalman Filters (KF) and a Master Filter (MF). The local KFs are designed by using the Direction Cosine Matrix (DCM)-based dynamic equations and the measurements from the two aiding systems. The KFs can estimate the attitude simultaneously to limit the attitude errors resulting from the gyros. Then, the MF fuses the redundant attitude estimates to yield globally optimal estimates. Simulation and experimental results demonstrate that the FKF-based system can improve the target positioning accuracy effectively and allow for good fault-tolerant capability. PMID:26512672

  20. An Accurate and Fault-Tolerant Target Positioning System for Buildings Using Laser Rangefinders and Low-Cost MEMS-Based MARG Sensors

    PubMed Central

    Zhao, Lin; Guan, Dongxue; Landry, René Jr.; Cheng, Jianhua; Sydorenko, Kostyantyn

    2015-01-01

    Target positioning systems based on MEMS gyros and laser rangefinders (LRs) have extensive prospects due to their advantages of low cost, small size and easy realization. The target positioning accuracy is mainly determined by the LR’s attitude derived by the gyros. However, the attitude error is large due to the inherent noises from isolated MEMS gyros. In this paper, both accelerometer/magnetometer and LR attitude aiding systems are introduced to aid MEMS gyros. A no-reset Federated Kalman Filter (FKF) is employed, which consists of two local Kalman Filters (KF) and a Master Filter (MF). The local KFs are designed by using the Direction Cosine Matrix (DCM)-based dynamic equations and the measurements from the two aiding systems. The KFs can estimate the attitude simultaneously to limit the attitude errors resulting from the gyros. Then, the MF fuses the redundant attitude estimates to yield globally optimal estimates. Simulation and experimental results demonstrate that the FKF-based system can improve the target positioning accuracy effectively and allow for good fault-tolerant capability. PMID:26512672

  1. Integrating cost information with health management support system: an enhanced methodology to assess health care quality drivers.

    PubMed

    Kohli, R; Tan, J K; Piontek, F A; Ziege, D E; Groot, H

    1999-08-01

    Changes in health care delivery, reimbursement schemes, and organizational structure have required health organizations to manage the costs of providing patient care while maintaining high levels of clinical and patient satisfaction outcomes. Today, cost information, clinical outcomes, and patient satisfaction results must become more fully integrated if strategic competitiveness and benefits are to be realized in health management decision making, especially in multi-entity organizational settings. Unfortunately, traditional administrative and financial systems are not well equipped to cater to such information needs. This article presents a framework for the acquisition, generation, analysis, and reporting of cost information with clinical outcomes and patient satisfaction in the context of evolving health management and decision-support system technology. More specifically, the article focuses on an enhanced costing methodology for determining and producing improved, integrated cost-outcomes information. Implementation issues and areas for future research in cost-information management and decision-support domains are also discussed. PMID:10539425

  2. Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information.

    PubMed

    Wang, Zhaoying; Liu, Bingwen; Zhao, Evan W; Jin, Ke; Du, Yingge; Neeway, James J; Ryan, Joseph V; Hu, Dehong; Zhang, Kelvin H L; Hong, Mina; Le Guernic, Solenne; Thevuthasan, Suntharampilai; Wang, Fuyi; Zhu, Zihua

    2015-08-01

    The use of an argon cluster ion sputtering source has been demonstrated to perform superiorly relative to traditional oxygen and cesium ion sputtering sources for ToF-SIMS depth profiling of insulating materials. The superior performance has been attributed to effective alleviation of surface charging. A simulated nuclear waste glass (SON68) and layered hole-perovskite oxide thin films were selected as model systems because of their fundamental and practical significance. Our results show that high sputter rates and accurate interfacial information can be achieved simultaneously for argon cluster sputtering, whereas this is not the case for cesium and oxygen sputtering. Therefore, the implementation of an argon cluster sputtering source can significantly improve the analysis efficiency of insulating materials and, thus, can expand its applications to the study of glass corrosion, perovskite oxide thin film characterization, and many other systems of interest. PMID:25953490

  3. Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information

    NASA Astrophysics Data System (ADS)

    Wang, Zhaoying; Liu, Bingwen; Zhao, Evan W.; Jin, Ke; Du, Yingge; Neeway, James J.; Ryan, Joseph V.; Hu, Dehong; Zhang, Kelvin H. L.; Hong, Mina; Le Guernic, Solenne; Thevuthasan, Suntharampilai; Wang, Fuyi; Zhu, Zihua

    2015-08-01

    The use of an argon cluster ion sputtering source has been demonstrated to perform superiorly relative to traditional oxygen and cesium ion sputtering sources for ToF-SIMS depth profiling of insulating materials. The superior performance has been attributed to effective alleviation of surface charging. A simulated nuclear waste glass (SON68) and layered hole-perovskite oxide thin films were selected as model systems because of their fundamental and practical significance. Our results show that high sputter rates and accurate interfacial information can be achieved simultaneously for argon cluster sputtering, whereas this is not the case for cesium and oxygen sputtering. Therefore, the implementation of an argon cluster sputtering source can significantly improve the analysis efficiency of insulating materials and, thus, can expand its applications to the study of glass corrosion, perovskite oxide thin film characterization, and many other systems of interest.

  4. The Economics of Information: A Guide to Economic and Cost-Benefit Analysis for Information Professionals. Library and Information Science Text Series.

    ERIC Educational Resources Information Center

    Kingma, Bruce R.

    This book provides readers with an introduction to economics and cost-benefit analysis and will be particularly valuable to individuals who are, or plan to be, managers of information services in academic, public, or special libraries. Part 1 provides a rational for economic studies in librarianship, specifically, gaining understanding of consumer…

  5. Waste management facilities cost information for transportation of radioactive and hazardous materials

    SciTech Connect

    Feizollahi, F.; Shropshire, D.; Burton, D.

    1995-06-01

    This report contains cost information on the U.S. Department of Energy (DOE) Complex waste streams that will be addressed by DOE in the programmatic environmental impact statement (PEIS) project. It describes the results of the task commissioned by DOE to develop cost information for transportation of radioactive and hazardous waste. It contains transportation costs for most types of DOE waste streams: low-level waste (LLW), mixed low-level waste (MLLW), alpha LLW and alpha MLLW, Greater-Than-Class C (GTCC) LLW and DOE equivalent waste, transuranic (TRU) waste, spent nuclear fuel (SNF), and hazardous waste. Unit rates for transportation of contact-handled (<200 mrem/hr contact dose) and remote-handled (>200 mrem/hr contact dose) radioactive waste are estimated. Land transportation of radioactive and hazardous waste is subject to regulations promulgated by DOE, the U.S. Department of Transportation (DOT), the U.S. Nuclear Regulatory Commission (NRC), and state and local agencies. The cost estimates in this report assume compliance with applicable regulations.

  6. Estimating costs of programme services and products using information provided in standard financial statements.

    PubMed Central

    Ellwein, L. B.; Thulasiraj, R. D.; Boulter, A. R.; Dhittal, S. P.

    1998-01-01

    The financial viability of programme services and product offerings requires that revenue exceeds expenses. Revenue includes payments for services and products as well as donor cash and in-kind contributions. Expenses reflect consumption of purchased or contributed time and materials and utilization (depreciation) of physical plant facilities and equipment. Standard financial reports contain this revenue and expense information, complemented when necessary by valuation and accounting of in-kind contributions. Since financial statements are prepared using consistent and accepted accounting practices, year-to-year and organization-to-organization comparisons can be made. The use of such financial information is illustrated in this article by determining the unit cost of cataract surgery in two hospitals in Nepal. The proportion of unit cost attributed to personnel, medical supplies, administrative materials, and depreciation varied significantly by institution. These variations are accounted for by examining differences in operational structure and capacity utilization. PMID:9868836

  7. SnowyOwl: accurate prediction of fungal genes by using RNA-Seq and homology information to select among ab initio models

    PubMed Central

    2014-01-01

    Background Locating the protein-coding genes in novel genomes is essential to understanding and exploiting the genomic information but it is still difficult to accurately predict all the genes. The recent availability of detailed information about transcript structure from high-throughput sequencing of messenger RNA (RNA-Seq) delineates many expressed genes and promises increased accuracy in gene prediction. Computational gene predictors have been intensively developed for and tested in well-studied animal genomes. Hundreds of fungal genomes are now or will soon be sequenced. The differences of fungal genomes from animal genomes and the phylogenetic sparsity of well-studied fungi call for gene-prediction tools tailored to them. Results SnowyOwl is a new gene prediction pipeline that uses RNA-Seq data to train and provide hints for the generation of Hidden Markov Model (HMM)-based gene predictions and to evaluate the resulting models. The pipeline has been developed and streamlined by comparing its predictions to manually curated gene models in three fungal genomes and validated against the high-quality gene annotation of Neurospora crassa; SnowyOwl predicted N. crassa genes with 83% sensitivity and 65% specificity. SnowyOwl gains sensitivity by repeatedly running the HMM gene predictor Augustus with varied input parameters and selectivity by choosing the models with best homology to known proteins and best agreement with the RNA-Seq data. Conclusions SnowyOwl efficiently uses RNA-Seq data to produce accurate gene models in both well-studied and novel fungal genomes. The source code for the SnowyOwl pipeline (in Python) and a web interface (in PHP) is freely available from http://sourceforge.net/projects/snowyowl/. PMID:24980894

  8. Cost comparison of Transcatheter and Operative Pulmonary Valve Replacement (from the Pediatric Health Information Systems Database).

    PubMed

    O'Byrne, Michael L; Gillespie, Matthew J; Shinohara, Russell T; Dori, Yoav; Rome, Jonathan J; Glatz, Andrew C

    2016-01-01

    Outcomes for transcatheter pulmonary valve replacement (TC-PVR) and operative pulmonary valve replacement (S-PVR) are excellent. Thus, their respective cost is a relevant clinical outcome. We performed a retrospective cohort study of children and adults who underwent PVR at age ≥ 8 years from January 1, 2011, to December 31, 2013, at 35 centers contributing data to the Pediatric Health Information Systems database to address this question. A propensity score-adjusted multivariable analysis was performed to adjust for known confounders. Secondary analyses of department-level charges, risk of re-admission, and associated costs were performed. A total of 2,108 PVR procedures were performed in 2,096 subjects (14% transcatheter and 86% operative). The observed cost of S-PVR and TC-PVR was not significantly different (2013US $50,030 vs 2013US $51,297; p = 0.85). In multivariate analysis, total costs of S-PVR and TC-PVR were not significantly different (p = 0.52). Length of stay was shorter after TC-PVR (p <0.0001). Clinical and supply charges were greater for TC-PVR (p <0.0001), whereas laboratory, pharmacy, and other charges (all p <0.0001) were greater for S-PVR. Risks of both 7- and 30-day readmission were not significantly different. In conclusion, short-term costs of TC-PVR and S-PVR are not significantly different after adjustment. PMID:26552510

  9. Energy information systems (EIS): Technology costs, benefit, and best practice uses

    SciTech Connect

    Granderson, Jessica; Lin, Guanjing; Piette, Mary Ann

    2013-11-26

    Energy information systems are the web-based software, data acquisition hardware, and communication systems used to store, analyze, and display building energy data. They often include analysis methods such as baselining, benchmarking, load profiling, and energy anomaly detection. This report documents a large-scale assessment of energy information system (EIS) uses, costs, and energy benefits, based on a series of focused case study investigations that are synthesized into generalizable findings. The overall objective is to provide organizational decision makers with the information they need to make informed choices as to whether or not to invest in an EIS--a promising technology that can enable up to 20 percent site energy savings, quick payback, and persistent low-energy performance when implemented as part of best-practice energy management programs.

  10. Know Thy Neighbor: Costly Information Can Hurt Cooperation in Dynamic Networks

    PubMed Central

    Antonioni, Alberto; Cacault, Maria Paula; Lalive, Rafael; Tomassini, Marco

    2014-01-01

    People need to rely on cooperation with other individuals in many aspects of everyday life, such as teamwork and economic exchange in anonymous markets. We study whether and how the ability to make or break links in social networks fosters cooperate, paying particular attention to whether information on an individual's actions is freely available to potential partners. Studying the role of information is relevant as information on other people's actions is often not available for free: a recruiting firm may need to call a job candidate's references, a bank may need to find out about the credit history of a new client, etc. We find that people cooperate almost fully when information on their actions is freely available to their potential partners. Cooperation is less likely, however, if people have to pay about half of what they gain from cooperating with a cooperator. Cooperation declines even further if people have to pay a cost that is almost equivalent to the gain from cooperating with a cooperator. Thus, costly information on potential neighbors' actions can undermine the incentive to cooperate in fluid networks. PMID:25356905

  11. 39 CFR 3050.30 - Information needed to estimate the cost of the universal service obligation. [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Information needed to estimate the cost of the universal service obligation. 3050.30 Section 3050.30 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.30 Information needed to estimate the cost of the universal service obligation....

  12. 39 CFR 3050.30 - Information needed to estimate the cost of the universal service obligation. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Information needed to estimate the cost of the universal service obligation. 3050.30 Section 3050.30 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.30 Information needed to estimate the cost of the universal service obligation....

  13. The value of information as applied to the Landsat Follow-on benefit-cost analysis

    NASA Technical Reports Server (NTRS)

    Wood, D. B.

    1978-01-01

    An econometric model was run to compare the current forecasting system with a hypothetical (Landsat Follow-on) space-based system. The baseline current system was a hybrid of USDA SRS domestic forecasts and the best known foreign data. The space-based system improved upon the present Landsat by the higher spatial resolution capability of the thematic mapper. This satellite system is a major improvement for foreign forecasts but no better than SRS for domestic forecasts. The benefit analysis was concentrated on the use of Landsat Follow-on to forecast world wheat production. Results showed that it was possible to quantify the value of satellite information and that there are significant benefits in more timely and accurate crop condition information.

  14. Information from Pharmaceutical Companies and the Quality, Quantity, and Cost of Physicians' Prescribing: A Systematic Review

    PubMed Central

    Spurling, Geoffrey K.; Mansfield, Peter R.; Montgomery, Brett D.; Lexchin, Joel; Doust, Jenny; Othman, Noordin; Vitry, Agnes I.

    2010-01-01

    Background Pharmaceutical companies spent $57.5 billion on pharmaceutical promotion in the United States in 2004. The industry claims that promotion provides scientific and educational information to physicians. While some evidence indicates that promotion may adversely influence prescribing, physicians hold a wide range of views about pharmaceutical promotion. The objective of this review is to examine the relationship between exposure to information from pharmaceutical companies and the quality, quantity, and cost of physicians' prescribing. Methods and Findings We searched for studies of physicians with prescribing rights who were exposed to information from pharmaceutical companies (promotional or otherwise). Exposures included pharmaceutical sales representative visits, journal advertisements, attendance at pharmaceutical sponsored meetings, mailed information, prescribing software, and participation in sponsored clinical trials. The outcomes measured were quality, quantity, and cost of physicians' prescribing. We searched Medline (1966 to February 2008), International Pharmaceutical Abstracts (1970 to February 2008), Embase (1997 to February 2008), Current Contents (2001 to 2008), and Central (The Cochrane Library Issue 3, 2007) using the search terms developed with an expert librarian. Additionally, we reviewed reference lists and contacted experts and pharmaceutical companies for information. Randomized and observational studies evaluating information from pharmaceutical companies and measures of physicians' prescribing were independently appraised for methodological quality by two authors. Studies were excluded where insufficient study information precluded appraisal. The full text of 255 articles was retrieved from electronic databases (7,185 studies) and other sources (138 studies). Articles were then excluded because they did not fulfil inclusion criteria (179) or quality appraisal criteria (18), leaving 58 included studies with 87 distinct analyses

  15. The Effects of Health Information Technology on the Costs and Quality of Medical Care

    PubMed Central

    Agha, Leila

    2015-01-01

    Information technology has been linked to productivity growth in a wide variety of sectors, and health information technology (HIT) is a leading example of an innovation with the potential to transform industry-wide productivity. This paper analyzes the impact of health information technology (HIT) on the quality and intensity of medical care. Using Medicare claims data from 1998-2005, I estimate the effects of early investment in HIT by exploiting variation in hospitals’ adoption statuses over time, analyzing 2.5 million inpatient admissions across 3900 hospitals. HIT is associated with a 1.3 percent increase in billed charges (p-value: 5.6%), and there is no evidence of cost savings even five years after adoption. Additionally, HIT adoption appears to have little impact on the quality of care, measured by patient mortality, adverse drug events, and readmission rates. PMID:24463141

  16. Mapping Health Outcome and Costs when Coordinating Local Information System Redesign.

    PubMed

    Walldius, Åke; Olve, Nils-Göran; Aminoff, Hedvig

    2015-01-01

    As costs for healthcare are rising in society, information systems are often seen as enablers of new cost-saving healthcare processes. But an on-going deployment of a wide range of new kinds of systems requires close attention to interoperability between new and legacy systems. Another challenge is to assure that the healthcare professions are given realistic opportunities to play an active part in designing the new ways of working that the new, integrated systems are designed to support. We argue that a feasible way to approach such a user participation in design of work processes and systems is to extend well known user-survey and strategy-mapping methods with the new value-based healthcare approach which invites health professionals to participate in strategic assessments of health outcome and costs along the care chain in which they work. We also argue that such a combination of practical research methods resonates well with Techno-Anthropology's foregrounding of ethical considerations to inform the interdisciplinary cross-fertilization of interactional competencies in health informatics research. PMID:26249201

  17. A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control

    PubMed Central

    Tamagnan, Jules A.; Medlock, Jan; Ndeffo-Mbah, Martial L.; Fish, Durland; Ávila-Agüero, María L.; Marín, Rodrigo; Ko, Albert I.; Galvani, Alison P.

    2016-01-01

    in real-time within our user-friendly tool to provide updated estimates on cost-effectiveness of interventions and inform policy decisions in country-specific settings. PMID:27205899

  18. Magnetic dipolar coupling and collective effects for binary information codification in cost-effective logic devices

    NASA Astrophysics Data System (ADS)

    Chiolerio, Alessandro; Allia, Paolo; Graziano, Mariagrazia

    2012-09-01

    Physical limitations foreshadow the eventual end to traditional Complementary Metal Oxide Semiconductor (CMOS) scaling. Therefore, interest has turned to various materials and technologies aimed to succeed to traditional CMOS. Magnetic Quantum dot Cellular Automata (MQCA) are one of these technologies. Working MQCA arrays require very complex techniques and an excellent control on the geometry of the nanomagnets and on the quality of the magnetic thin film, thus limiting the possibility for MQCA of representing a definite solution to cost-effective, high density and low power consumption device demand. Counter-intuitively, moving towards bigger sizes and lighter technologies it is still possible to develop multi-state logic devices, as we demonstrated, whose main advantage is cost-effectiveness. Applications may be seen in low cost logic devices where integration and computational power are not the main issue, eventually using flexible substrates and taking advantage of the intrinsic mechanical toughness of systems where long range interactions do not need wirings. We realized cobalt micrometric MQCA arrays by means of Electron Beam Lithography, exploiting cost-effective processes such as lift-off and RF sputtering that usually are avoided due to their low control on array geometry and film roughness. Information relative to the magnetic configuration of MQCA elements including their eventual magnetic interactions was obtained from Magnetic Force Microscope (MFM) images, enhanced by means of a numerical procedure and presented in differential maps. We report the existence of bi-stable magnetic patterns, as detected by MFM while sampling the z-component of magnetic induction field, arising from dipolar inter-element magnetostatic coupling, able to store and propagate binary information. This is achieved despite the array quality and element magnetic state, which are low and multi-domain, respectively. We discuss in detail shape, inter-element spacing and dot profile

  19. Effective information channels for reducing costs of environmentally- friendly technologies: evidence from residential PV markets

    NASA Astrophysics Data System (ADS)

    Rai, Varun; Robinson, Scott A.

    2013-03-01

    Realizing the environmental benefits of solar photovoltaics (PV) will require reducing costs associated with perception, informational gaps and technological uncertainties. To identify opportunities to decrease costs associated with residential PV adoption, in this letter we use multivariate regression models to analyze a unique, household-level dataset of PV adopters in Texas (USA) to systematically quantify the effect of different information channels on aspiring PV adopters’ decision-making. We find that the length of the decision period depends on the business model, such as whether the system was bought or leased, and on special opportunities to learn, such as the influence of other PV owners in the neighborhood. This influence accrues passively through merely witnessing PV systems in the neighborhood, increasing confidence and motivation, as well as actively through peer-to-peer communications. Using these insights we propose a new framework to provide public information on PV that could drastically reduce barriers to PV adoption, thereby accelerating its market penetration and environmental benefits. This framework could also serve as a model for other distributed generation technologies.

  20. Costs and effects of a nursing information system in three Dutch hospitals.

    PubMed

    van Gennip, E M; Klaassen-Leil, C C; Stokman, R; van Valkenburg, R K

    1995-01-01

    VISION is an integrated nursing information system developed in the Netherlands. In mid-1992, a technology assessment of this system was started: the VISTA project. Its aim is to assess the costs and effects of VISION in three different types of hospitals: a University Hospital, a General Hospital, and a Psychiatric Hospital. The study was financially supported by the Dutch Ministry of Welfare, Health, and Culture. Each hospital selected an experimental ward at which VISION parts were installed (VISION was not yet complete during the study). Also, control wards were selected at which no VISION parts were installed. A series of two measurements were carried out at the experimental and control wards. The first experiences show that VISION can be used in various applications, in different environments. Although the second measurements were done just a few weeks after the installation of VISION parts, first effects could already be demonstrated. Nurses were enthusiastic and the quality of coordination of care increased. Time savings have not yet been demonstrated, but are expected after a longer, more extensive use of the system. Extrapolation of costs for hospital-wide implementation revealed that the costs of VISION are low compared to similar systems in the US. After reviewing the first results, each hospital decided to continue the implementation of VISION parts. More measurements are planned. PMID:8591462

  1. Case studies of energy information systems and related technology: Operational practices, costs, and benefits

    SciTech Connect

    Motegi, Naoya; Piette, Mary Ann; Kinney, Satkartar; Dewey, Jim

    2003-09-02

    Energy Information Systems (EIS), which can monitor and analyze building energy consumption and related data throughout the Internet, have been increasing in use over the last decade. Though EIS developers describe the capabilities, costs, and benefits of EIS, many of these descriptions are idealized and often insufficient for potential users to evaluate cost, benefit and operational usefulness. LBNL has conducted a series of case studies of existing EIS and related technology installations. This study explored the following questions: (1) How is the EIS used in day-to-day operation? (2) What are the costs and benefits of an EIS? (3) Where do the energy savings come from? This paper reviews the process of these technologies from installation through energy management practice. The study is based on interviews with operators and energy managers who use EIS. Analysis of energy data trended by EIS and utility bills was also conducted to measure the benefit. This paper explores common uses and findings to identify energy savings attributable to EIS, and discusses non-energy benefits as well. This paper also addresses technologies related to EIS that have been demonstrated and evaluated by LBNL.

  2. Risk information in support of cost estimates for the Baseline Environmental Management Report (BEMR). Section 1

    SciTech Connect

    Gelston, G.M.; Jarvis, M.F.; Warren, B.R.; Von Berg, R.

    1995-06-01

    The Pacific Northwest Laboratory (PNL)(1) effort on the overall Baseline Environmental Management Report (BEMR) project consists of four installation-specific work components performed in succession. These components include (1) development of source terms, 92) collection of data and preparation of environmental settings reports, (3) calculation of unit risk factors, and (4) utilization of the unit risk factors in Automated Remedial Action Methodology (ARAM) for computation of target concentrations and cost estimates. This report documents work completed for the Nevada Test Site, Nevada, for components 2 and 3. The product of this phase of the BEMR project is the development of unit factors (i.e., unit transport factors, unit exposure factors, and unit risk factors). Thousands of these unit factors are gene rated and fill approximately one megabyte of computer information per installation. The final unit risk factors (URF) are transmitted electronically to BEMR-Cost task personnel as input to a computer program (ARAM). Abstracted files and exhibits of the URF information are included in this report. These visual formats are intended to provide a sample of the final task deliverable (the URF files) which can be easily read without a computer.

  3. Effectiveness and cost of different strategies for information feedback in general practice.

    PubMed Central

    Szczepura, A; Wilmot, J; Davies, C; Fletcher, J

    1994-01-01

    AIM. The aim of this study was to determine the effectiveness and relative cost of three forms of information feedback to general practices--graphical, graphical plus a visit by a medical facilitator and tabular. METHOD. Routinely collected, centrally-held data were used where possible, analysed at practice level. Some non-routine practice data in the form of risk factor recording in medical notes, for example weight, smoking status, alcohol consumption and blood pressure, were also provided to those who requested it. The 52 participating practices were stratified and randomly allocated to one of the three feedback groups. The cost of providing each type of feedback was determined. The immediate response of practitioners to the form of feedback (acceptability), ease of understanding (intelligibility), and usefulness of regular feedback was recorded. Changes introduced as a result of feedback were assessed by questionnaire shortly after feedback, and 12 months later. Changes at the practice level in selected indicators were also assessed 12 and 24 months after initial feedback. RESULTS. The resulting cost per effect was calculated to be 46.10 pounds for both graphical and tabular feedback, 132.50 pounds for graphical feedback plus facilitator visit and 773.00 pounds for the manual audit of risk factors recorded in the practice notes. The three forms of feedback did not differ in intelligibility or usefulness, but feedback plus a medical facilitator visit was significantly less acceptable. There was a high level of self-reported organizational change following feedback, with 69% of practices reporting changes as a direct result; this was not significantly different for the three types of feedback. There were no significant changes in the selected indicators at 12 or 24 months following feedback. The practice characteristic most closely related to better indicators of preventive practice was practice size, smaller practices performing significantly better. Separate

  4. The Perceived Effect of Hidden Costs on the Operational Management of Information Technology Outsourcing: A Qualitative Study

    ERIC Educational Resources Information Center

    Swift, Ian

    2011-01-01

    Information technology (IT) outsourcing is a business trend aimed at reducing costs and enabling companies to concentrate on their core competencies. This qualitative multiple case design research study explored the effects of hidden costs on the operational management of IT outsourcing. The study involved analyzing IT outsourcing agreements as…

  5. Digital Avionics Information System (DAIS): Impact of DAIS Concept on Life Cycle Cost--Supplement. Final Report.

    ERIC Educational Resources Information Center

    Goclowski, John C.; And Others

    This supplement to a technical report providing the results of a preliminary investigation of the potential impact of the Digital Avionics Information System (DAIS) concept on system support personnel requirements and life cycle cost (LCC) includes: (1) additional details of the cost comparison of a hypothetical application of a conceptual…

  6. Layer-switching cost and optimality in information spreading on multiplex networks

    PubMed Central

    Min, Byungjoon; Gwak, Sang-Hwan; Lee, Nanoom; Goh, K. -I.

    2016-01-01

    We study a model of information spreading on multiplex networks, in which agents interact through multiple interaction channels (layers), say online vs. offline communication layers, subject to layer-switching cost for transmissions across different interaction layers. The model is characterized by the layer-wise path-dependent transmissibility over a contact, that is dynamically determined dependently on both incoming and outgoing transmission layers. We formulate an analytical framework to deal with such path-dependent transmissibility and demonstrate the nontrivial interplay between the multiplexity and spreading dynamics, including optimality. It is shown that the epidemic threshold and prevalence respond to the layer-switching cost non-monotonically and that the optimal conditions can change in abrupt non-analytic ways, depending also on the densities of network layers and the type of seed infections. Our results elucidate the essential role of multiplexity that its explicit consideration should be crucial for realistic modeling and prediction of spreading phenomena on multiplex social networks in an era of ever-diversifying social interaction layers. PMID:26887527

  7. Layer-switching cost and optimality in information spreading on multiplex networks

    NASA Astrophysics Data System (ADS)

    Min, Byungjoon; Gwak, Sang-Hwan; Lee, Nanoom; Goh, K.-I.

    2016-02-01

    We study a model of information spreading on multiplex networks, in which agents interact through multiple interaction channels (layers), say online vs. offline communication layers, subject to layer-switching cost for transmissions across different interaction layers. The model is characterized by the layer-wise path-dependent transmissibility over a contact, that is dynamically determined dependently on both incoming and outgoing transmission layers. We formulate an analytical framework to deal with such path-dependent transmissibility and demonstrate the nontrivial interplay between the multiplexity and spreading dynamics, including optimality. It is shown that the epidemic threshold and prevalence respond to the layer-switching cost non-monotonically and that the optimal conditions can change in abrupt non-analytic ways, depending also on the densities of network layers and the type of seed infections. Our results elucidate the essential role of multiplexity that its explicit consideration should be crucial for realistic modeling and prediction of spreading phenomena on multiplex social networks in an era of ever-diversifying social interaction layers.

  8. Cost and results of information systems for health and poverty indicators in the United Republic of Tanzania.

    PubMed Central

    Rommelmann, Vanessa; Setel, Philip W.; Hemed, Yusuf; Angeles, Gustavo; Mponezya, Hamisi; Whiting, David; Boerma, Ties

    2005-01-01

    OBJECTIVE: To examine the costs of complementary information generation activities in a resource-constrained setting and compare the costs and outputs of information subsystems that generate the statistics on poverty, health and survival required for monitoring, evaluation and reporting on health programmes in the United Republic of Tanzania. METHODS: Nine systems used by four government agencies or ministries were assessed. Costs were calculated from budgets and expenditure data made available by information system managers. System coverage, quality assurance and information production were reviewed using questionnaires and interviews. Information production was characterized in terms of 38 key sociodemographic indicators required for national programme monitoring. FINDINGS: In 2002-03 approximately US$ 0.53 was spent per Tanzanian citizen on the nine information subsystems that generated information on 37 of the 38 selected indicators. The census and reporting system for routine health service statistics had the largest participating populations and highest total costs. Nationally representative household surveys and demographic surveillance systems (which are not based on nationally representative samples) produced more than half the indicators and used the most rigorous quality assurance. Five systems produced fewer than 13 indicators and had comparatively high costs per participant. CONCLUSION: Policy-makers and programme planners should be aware of the many trade-offs with respect to system costs, coverage, production, representativeness and quality control when making investment choices for monitoring and evaluation. In future, formal cost-effectiveness studies of complementary information systems would help guide investments in the monitoring, evaluation and planning needed to demonstrate the impact of poverty-reduction and health programmes. PMID:16184275

  9. College Attendance Costs Vary and Result from Higher Tuition, Room, and Board. OPPAGA Information Brief.

    ERIC Educational Resources Information Center

    Florida State Legislature, Tallahassee. Office of Program Policy Analysis and Government Accountability.

    College students must pay for educational expenses and living costs. Educational expenses account for 18 to 25% of the cost of college attendance. The cost of attending college, as calculated by each institution, is used to determine a student's financial need and eligibility for financial aid. The cost of attendance varies among institutions,…

  10. Cost model for biobanks.

    PubMed

    Gonzalez-Sanchez, M Beatriz; Lopez-Valeiras, Ernesto; Morente, Manuel M; Fernández Lago, Orlando

    2013-10-01

    Current economic conditions and budget constraints in publicly funded biomedical research have brought about a renewed interest in analyzing the cost and economic viability of research infrastructures. However, there are no proposals for specific cost accounting models for these types of organizations in the international scientific literature. The aim of this paper is to present the basis of a cost analysis model useful for any biobank regardless of the human biological samples that it stores for biomedical research. The development of a unique cost model for biobanks can be a complicated task due to the diversity of the biological samples they store. Different types of samples (DNA, tumor tissues, blood, serum, etc.) require different production processes. Nonetheless, the common basic steps of the production process can be identified. Thus, the costs incurred in each step can be analyzed in detail to provide cost information. Six stages and four cost objects were obtained by taking the production processes of biobanks belonging to the Spanish National Biobank Network as a starting point. Templates and examples are provided to help managers to identify and classify the costs involved in their own biobanks to implement the model. The application of this methodology will provide accurate information on cost objects, along with useful information to give an economic value to the stored samples, to analyze the efficiency of the production process and to evaluate the viability of some sample collections. PMID:24835258

  11. The Telecommunications Stranglehold on Europe's Information Use: Practical Constraints for SMEs and Economic Assessment Based on Cost Models.

    ERIC Educational Resources Information Center

    Delcroix, Jean-Claude

    There is a general feeling that European telecommunications are delaying the introduction of new information services. This paper responds to some of the questions concerning online information. The views result from research work at DECADE (Belgium) on the requirements of smaller organizations on the one hand and on telecommunications costs on…

  12. Food Assistance: Financial Information on WIC Nutrition Services and Administrative Costs. United States General Accounting Office Report to Congressional Committees.

    ERIC Educational Resources Information Center

    Robertson, Robert E.

    The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federally funded nutrition assistance program administered by the Department of Agriculture's (USDA) Food and Nutrition Service (FNS). Responding to Congressional requests for information regarding program costs, this report provides information on: (1) funding…

  13. Towards a personalized environmental health information service using low-cost sensors and crowdsourcing

    NASA Astrophysics Data System (ADS)

    Castell, Nuria; Liu, Hai-Ying; Schneider, Philipp; Cole-Hunter, Tom; Lahoz, William; Bartonova, Alena

    2015-04-01

    Most European cities exceed the air quality guidelines established by the WHO to protect human health. As such, citizens are exposed to potentially harmful pollutant levels. Some cities have services (e.g., web pages, mobile apps, etc.) which provide timely air quality information to the public. However, air quality data at individual level is currently scarce or non-existent. Making this information directly useful to individuals poses a challenge. For instance, if a user is informed that the air quality is "poor", what does that mean for him/her, and how can this information be acted upon? Despite individuals having a unique relationship with their environment, the information on the state of atmospheric components and related hazards is currently mostly generic, and seldom personally relevant. This undermines citizens' interest in their environment, and consequently limits their ability to recognize and change both their contribution and their exposure to air pollution. In Oslo, two EU founded projects, CITI-SENSE (Engelken-Jorge et al., 2014) and Citi-Sense-MOB (Castell et al., 2014), are trying to establish a dialogue with citizens by providing them with the possibility of getting personalized air quality information on their smartphones. The users are able to check the air quality in their immediate surroundings and track their individual exposure while moving through the urban environment (Castell et al., 2014). In this way, they may be able to reduce their exposure such as by changing transport modes or routes, for example by selecting less polluted streets to walk or cycle through. Using a smartphone application, citizens are engaged in collecting and sharing environmental data generated by low-cost air quality sensors, and in reporting their individual perception (turning citizens into sensors themselves). The highly spatially resolved data on air quality and perception is geo-located. This allows for simultaneous visualization of both kinds of the sensor

  14. Sexual harassment induces a temporary fitness cost but does not constrain the acquisition of environmental information in fruit flies.

    PubMed

    Teseo, Serafino; Veerus, Liisa; Moreno, Céline; Mery, Frédéric

    2016-01-01

    Across animals, sexual harassment induces fitness costs for females and males. However, little is known about the cognitive costs involved, i.e. whether it constrains learning processes, which could ultimately affect an individual's fitness. Here we evaluate the acquisition of environmental information in groups of fruit flies challenged with various levels of male sexual harassment. We show that, although high sexual harassment induces a temporary fitness cost for females, all fly groups of both sexes exhibit similar levels of learning. This suggests that, in fruit flies, the fitness benefits of acquiring environmental information are not affected by the fitness costs of sexual harassment, and that selection may favour cognition even in unfavourable social contexts. Our study provides novel insights into the relationship between sexual conflicts and cognition and the evolution of female counterstrategies against male sexual harassment. PMID:26763219

  15. Waste Management Facilities Cost Information report for Greater-Than-Class C and DOE equivalent special case waste

    SciTech Connect

    Feizollahi, F.; Shropshire, D.

    1993-07-01

    This Waste Management Facility Cost Information (WMFCI) report for Greater-Than-Class C low-level waste (GTCC LLW) and DOE equivalent special case waste contains preconceptual designs and planning level life-cycle cost (PLCC) estimates for treatment, storage, and disposal facilities needed for management of GTCC LLW and DOE equivalent waste. The report contains information on 16 facilities (referred to as cost modules). These facilities are treatment facility front-end and back-end support functions (administration support, and receiving, preparation, and shipping cost modules); seven treatment concepts (incineration, metal melting, shredding/compaction, solidification, vitrification, metal sizing and decontamination, and wet/air oxidation cost modules); two storage concepts (enclosed vault and silo); disposal facility front-end functions (disposal receiving and inspection cost module); and four disposal concepts (shallow-land, engineered shallow-land, intermediate depth, and deep geological cost modules). Data in this report allow the user to develop PLCC estimates for various waste management options. A procedure to guide the U.S. Department of Energy (DOE) and its contractor personnel in the use of estimating data is also included in this report.

  16. Draft Submission; Social Cost of Energy Generation

    SciTech Connect

    1990-01-05

    This report is intended to provide a general understanding of the social costs associated with electric power generation. Based on a thorough review of recent literature on the subject, the report describes how these social costs can be most fully and accurately evaluated, and discusses important considerations in applying this information within the competitive bidding process. [DJE 2005

  17. Engaged patients will need comparative physician-level quality data and information about their out-of-pocket costs.

    PubMed

    Yegian, Jill Mathews; Dardess, Pam; Shannon, Maribeth; Carman, Kristin L

    2013-02-01

    For patients to be engaged, they will need meaningful and comparable information about the quality and cost of health care. We conducted a literature review and key-informant interviews, reviewed selected online reporting tools, and found that quality and cost reporting fell into two categories. One emphasizes public reporting of information, supported by philanthropic or government institutions that aim to improve provider quality and efficiency. The other is characterized by proprietary websites that aim to provide personalized, integrated information on cost and quality to support consumers' decision making on providers and services. What consumers seem to want is quality data at the physician level and cost data that reflect their personal out-of-pocket exposure. These needs will be acute under the coverage expansions inherent in the Affordable Care Act. State and federal policy thus should support all-payer claims databases, standards for electronic health records to facilitate sharing of quality data, and a unified approach to presenting information that prioritizes consumers' needs. PMID:23381526

  18. HMO contracting: know your costs.

    PubMed

    Astle, S; Roth, R

    1987-07-01

    HMO contracting requires a detailed knowledge of patient costs. We addressed the need for sophisticated cost accounting and patient information systems as it pertains to HMO contracting. Agencies cannot afford to overlook the global applications of such systems. The ability of an agency to make informed and competitive financial decisions in any price-based payment environment is critical. A system that can accurately identify and assist with forecasting costs will be a valuable asset for an agency as it moves toward the price-based payment environment of the future. PMID:10301849

  19. Using value-based total cost of ownership (TCO) measures to inform subsystem trade-offs

    NASA Astrophysics Data System (ADS)

    Radziwill, Nicole M.; DuPlain, Ronald F.

    2010-07-01

    Total Cost of Ownership (TCO) is a metric from management accounting that helps expose both the direct and indirect costs of a business decision. However, TCO can sometimes be too simplistic for "make vs. buy" decisions (or even choosing between competing design alternatives) when value and extensibility are more critical than total cost. A three-dimensional value-based TCO, which was developed to clarify product decisions for an observatory prior to Final Design Review (FDR), will be presented in this session. This value-based approach incorporates priority of requirements, satisfiability of requirements, and cost, and can be easily applied in any environment.

  20. An initial assessment of the cost and utilization of the Integrated Academic Information System (IAIMS) at Columbia Presbyterian Medical Center.

    PubMed Central

    Clayton, P. D.; Anderson, R. K.; Hill, C.; McCormack, M.

    1991-01-01

    The concept of "one stop information shopping" is becoming a reality at Columbia Presbyterian Medical Center (CPMC). The goal of our effort is to provide access to university and hospital administrative systems as well as clinical and library applications from a single workstation, which also provides utility functions such as word processing and mail. Since June 1987, CPMC has invested the equivalent of $23 million dollars to install a digital communications network that encompasses 18 buildings at seven geographically separate sites and to develop clinical and library applications that are integrated with the existing hospital and university administrative and research computing facilities. During June 1991, 2425 different individuals used the clinical information system, 425 different individuals used the library applications, and 900 different individuals used the hospital administrative applications via network access. If we were to freeze the system in its current state, amortize the development and network installation costs, and add projected maintenance costs for the clinical and library applications, our integrated information system would cost $2.8 million on an annual basis. This cost is 0.3% of the medical center's annual budget. These expenditures could be justified by very small improvements in time savings for personnel and/or decreased length of hospital stay and/or more efficient use of resources. In addition to the direct benefits which we detail, a major benefit is the ease with which additional computer-based applications can be added incrementally at an extremely modest cost. PMID:1666966

  1. Development of Cost Benefit Methodology for Scientific and Technical Information Communication and Application to Information Analysis Centers. Final Report.

    ERIC Educational Resources Information Center

    Mason, Robert M.; And Others

    This document presents a research effort intended to improve the economic information available for formulating politics and making decisions related to Information Analysis Centers (IAC's) and IAC services. The project used a system of IAC information activities to analyze the functional aspects of IAC services, calculate the present value of net…

  2. The Costs and Benefits of Information Technology Networking: A Contrast and Comparison of Networking in Business and Law Schools.

    ERIC Educational Resources Information Center

    Permual, R. Muruga

    1998-01-01

    Examines and compares the cost and benefit factors involved in networking information technologies in education and training in the specific fields of business (management education) and law. Discusses the diversity of networking, describes teaching methods in law schools, and offers recommendations for successful networking. (Author/LRW)

  3. Student Awareness of Costs and Benefits of Educational Decisions: Effects of an Information Campaign. CEE DP 139

    ERIC Educational Resources Information Center

    McGuigan, Martin; McNally, Sandra; Wyness, Gill

    2012-01-01

    The economic benefits of staying on in education have been well established. But do students know this? One of the reasons why students might drop out of education too soon is because they are not well informed about the costs and benefits of staying on in education at an appropriate time of their educational career. Indeed, the fact that…

  4. The Options Handbook. Communicating with Prospective Students About Postsecondary Educational Options. Handbook Two: Information Dissemination Concerning Costs and Financial Aid.

    ERIC Educational Resources Information Center

    Carlson, Mary S., Ed.; Berlet, Chip, Ed.

    In the present complex and changing context students and families are looking for information tools to help them identify financial planning constants to allow them to reduce the number of unknown factors that can be barriers to the completion of a personal financial package to cover the cost of higher education. This handbook is designed to…

  5. Cost-Effectiveness Analysis. Instructor Guide. Working for Clean Water: An Information Program for Advisory Groups.

    ERIC Educational Resources Information Center

    Buskirk, E. Drannon, Jr.

    Presented is the instructor's manual for a one-hour presentation on cost-effectiveness analysis. Topics covered are the scope of cost-effectiveness analysis, basic assessment procedures, and the role of citizens in the analysis of alternatives. A supplementary audiovisual program is available. These materials are part of the Working for Clean…

  6. 19 CFR 10.21 - Updating cost data and other information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... data. Actual cost data must be submitted as soon as accounting procedures permit. To insure that... because of the accounting period normally used in the trade, or because of other relevant circumstances....

  7. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... estimated annual reporting burden is increased from that published in the Federal Register at 75 FR 3236, on... NE., Washington, DC 20417. ATTN: Hada Flowers/IC 9000-0129, Cost Accounting Standards...

  8. FRTR COST AND PERFORMANCE REMEDIATION CASE STUDIES AND RELATED INFORMATION, FOURTH EDITION

    EPA Science Inventory

    The CD-ROM contains over 350 cost and performance technology case study reports and other publications related to the work by the Federal Remediation Technologies Roundtable. The reports were compiled from previously published case studies developed by federal agencies.

  9. FRTR COST & PERFORMANCE REMEDIATION CASE STUDIES AND RELATED INFORMATION, 3RD EDITION

    EPA Science Inventory

    The CD contains over 320 cost and performance technology case study reports and other publications related to the work by the Federal Remediation Technologies Roundtable. The reports compiled were previously published by the member agencies.

  10. Economically and environmentally informed policy for road resurfacing: tradeoffs between costs and greenhouse gas emissions

    NASA Astrophysics Data System (ADS)

    Reger, Darren; Madanat, Samer; Horvath, Arpad

    2014-10-01

    As road conditions worsen, users experience an increase in fuel consumption and vehicle wear and tear. This increases the costs incurred by the drivers, and also increases the amount of greenhouse gases (GHGs) that vehicles emit. Pavement condition can be improved through rehabilitation activities (resurfacing) to reduce the effects on users, but these activities also have significant cost and GHG emission impacts. The objective of pavement management is to minimize total societal (user and agency) costs. However, the environmental impacts associated with the cost-minimizing policy are not currently accounted for. We show that there exists a range of potentially optimal decisions, known as the Pareto frontier, in which it is not possible to decrease total emissions without increasing total costs and vice versa. This research explores these tradeoffs for a system of pavement segments. For a case study, a network was created from a subset of California’s highways using available traffic data. It was shown that the current resurfacing strategy used by the state’s transportation agency, Caltrans, does not fall on the Pareto frontier, meaning that significant savings in both total costs and total emissions can be achieved by switching to one of the optimal policies. The methods presented in this paper also allow the decision maker to evaluate the impact of other policies, such as reduced vehicle kilometers traveled or better construction standards.

  11. Lost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans

    PubMed Central

    Green, AR; King, MV; Shortall, SE; Fone, KCF

    2012-01-01

    3,4-Methylenedioxymethamphetamine (MDMA) induces both acute adverse effects and long-term neurotoxic loss of brain 5-HT neurones in laboratory animals. However, when choosing doses, most preclinical studies have paid little attention to the pharmacokinetics of the drug in humans or animals. The recreational use of MDMA and current clinical investigations of the drug for therapeutic purposes demand better translational pharmacology to allow accurate risk assessment of its ability to induce adverse events. Recent pharmacokinetic studies on MDMA in animals and humans are reviewed and indicate that the risks following MDMA ingestion should be re-evaluated. Acute behavioural and body temperature changes result from rapid MDMA-induced monoamine release, whereas long-term neurotoxicity is primarily caused by metabolites of the drug. Therefore acute physiological changes in humans are fairly accurately mimicked in animals by appropriate dosing, although allometric dosing calculations have little value. Long-term changes require MDMA to be metabolized in a similar manner in experimental animals and humans. However, the rate of metabolism of MDMA and its major metabolites is slower in humans than rats or monkeys, potentially allowing endogenous neuroprotective mechanisms to function in a species specific manner. Furthermore acute hyperthermia in humans probably limits the chance of recreational users ingesting sufficient MDMA to produce neurotoxicity, unlike in the rat. MDMA also inhibits the major enzyme responsible for its metabolism in humans thereby also assisting in preventing neurotoxicity. These observations question whether MDMA alone produces long-term 5-HT neurotoxicity in human brain, although when taken in combination with other recreational drugs it may induce neurotoxicity. LINKED ARTICLES This article is commented on by Parrott, pp. 1518–1520 of this issue. To view this commentary visit http://dx.doi.org/10.1111/j.1476-5381.2012.01941.x and to view the the

  12. 78 FR 18338 - Information Collections Being Reviewed by the Federal Communications Commission, Comments Requested

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... ILECs. Shapefiles are a commonly used, digitized, geographic information system (GIS) format. Accurate..., high cost carriers. After the shapefiles are uploaded into a web interface provided by the...

  13. Student Information Systems Demystified: The Increasing Demand for Accurate, Timely Data Means Schools and Districts Are Relying Heavily on SIS Technologies

    ERIC Educational Resources Information Center

    McIntire, Todd

    2004-01-01

    Student information systems, one of the first applications of computer technology in education, are undergoing a significant transition yet again. The first major shift in SIS technologies occurred about 15 years ago when they evolved from mainframe programs to client-server solutions. Now, vendors across the board are offering centralized…

  14. An Examination of the Explicit Costs of Sensitive Information Security Breaches

    ERIC Educational Resources Information Center

    Toe, Cleophas Adeodat

    2013-01-01

    Data security breaches are categorized as loss of information that is entrusted in an organization by its customers, partners, shareholders, and stakeholders. Data breaches are significant risk factors for companies that store, process, and transmit sensitive personal information. Sensitive information is defined as confidential or proprietary…

  15. Investing in International Information Exchange Activities to Improve the Safety, Cost Effectiveness and Schedule of Cleanup - 13281

    SciTech Connect

    Seed, Ian; James, Paula; Mathieson, John; Judd, Laurie; Elmetti-Ramirez, Rosa; Han, Ana

    2013-07-01

    With decreasing budgets and increasing pressure on completing cleanup missions as quickly, safely and cost-effectively as possible, there is significant benefit to be gained from collaboration and joint efforts between organizations facing similar issues. With this in mind, the US Department of Energy (DOE) and the UK Nuclear Decommissioning Authority (NDA) have formally agreed to share information on lessons learned on the development and application of new technologies and approaches to improve the safety, cost effectiveness and schedule of the cleanup legacy wastes. To facilitate information exchange a range of tools and methodologies were established. These included tacit knowledge exchange through facilitated meetings, conference calls and Site visits as well as explicit knowledge exchange through document sharing and newsletters. A DOE web-based portal has been established to capture these exchanges and add to them via discussion boards. The information exchange is operating at the Government-to-Government strategic level as well as at the Site Contractor level to address both technical and managerial topic areas. This effort has resulted in opening a dialogue and building working relationships. In some areas joint programs of work have been initiated thus saving resource and enabling the parties to leverage off one another activities. The potential benefits of high quality information exchange are significant, ranging from cost avoidance through identification of an approach to a problem that has been proven elsewhere to cost sharing and joint development of a new technology to address a common problem. The benefits in outcomes significantly outweigh the costs of the process. The applicability of the tools and methods along with the lessons learned regarding some key issues is of use to any organization that wants to improve value for money. In the waste management marketplace, there are a multitude of challenges being addressed by multiple organizations and

  16. Examining the Potential of Information Technologies to Improve Cost Control in Community Colleges

    ERIC Educational Resources Information Center

    Sudhakar, Samuel

    2013-01-01

    The challenges facing publicly funded community colleges have never been greater. Declining state and federal support and decreasing property tax revenues have placed a tremendous pressure on tuition rates. Declining revenues combined with the lack of adequate cost control, has caused in-state tuition and fees at public 2-year colleges to increase…

  17. Rationales for Determining Student Contributions to Costs of Post-Secondary Education. Research and Information Report.

    ERIC Educational Resources Information Center

    Hunka, Steve

    Student financial contributions toward postsecondary education are examined in this report from the Minister's Task Force in Alberta, Canada. Critical examination of various rationales are made as a basis for determining the directions in which student costs should move. This includes a discussion of social equity, societal investment and benefit,…

  18. Least-cost groundwater remediation design using uncertain hydrogeological information. 1998 annual progress report

    SciTech Connect

    Pinder, G.F.

    1998-06-01

    'The objective of the project is to formulate, test, and evaluate a new approach to the least-cost design of groundwater contamination containment and decontamination systems. The proposed methodology employs robust optimization, the outer-approximation method of non-linear programming, and groundwater flow and transport modeling to find the most cost-effective pump-and-treat design possible given the physical parameters describing the groundwater reservoir are known with uncertainty. The result is a methodology that will provide the least-cost groundwater remediation design possible given a specified set of design objectives and physical and sociological constraints. As of the end of the first year of this 3-year project the author has developed and tested the concept of robust optimization within the framework of least-cost groundwater-contamination-containment design. The outer-approximation method has been employed in this context for the relatively simple linear-constraint case associated with the containment problem. In an effort to enhance the efficiency and applicability of this methodology, a new strategy for selecting the various realizations arising out of the Monte-Carlo underpinnings of the robust-optimization technique has been developed and tested. Based upon observations arising out of this work a yet more promising approach has been discovered. The theoretical foundation for this most recent approach has been, and continues to be, the primary focus of the research.'

  19. Shaker K(+)-channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors.

    PubMed Central

    Niven, J E; Vähäsöyrinki, M; Juusola, M

    2003-01-01

    Shaker K(+)-channels are one of several voltage-activated K(+)-channels expressed in Drosophila photoreceptors. We have shown recently that Shaker channels act as selective amplifiers, attenuating some signals while boosting others. Loss of these channels reduces the photoreceptor information capacity (bits s(-1)) and induces compensatory changes in photoreceptors enabling them to minimize the impact of this loss upon coding natural-like stimuli. Energy as well as coding is also an important consideration in understanding the role of ion channels in neural processing. Here, we use a simple circuit model that incorporates the major ion channels, pumps and exchangers of the photoreceptors to derive experimentally based estimates of the metabolic cost of neural information in wild-type (WT) and Shaker mutant photoreceptors. We show that in WT photoreceptors, which contain Shaker K(+)-channels, each bit of information costs approximately half the number of ATP molecules than each bit in Shaker photoreceptors, in which lack of the Shaker K(+)-channels is compensated by increased leak conductance. Additionally, using a Hodgkin-Huxley-type model coupled to the circuit model we show that the amount of leak present in both WT and Shaker photoreceptors is optimized to both maximize the available voltage range and minimize the metabolic cost. PMID:12952637

  20. Allocating Information Costs in a Negotiated Information Order: Interorganizational Constraints on Decision Making in Norwegian Oil Insurance.

    ERIC Educational Resources Information Center

    Heimer, Carol A.

    1985-01-01

    This paper analyzes two types of decisions for insuring mobile oil rigs and fixed installations in the Norwegian North Sea: (1) decisions about information for ratemaking and underwriting, and (2) decisions about the conditions of insurance. Appended are 46 references. (MLF)

  1. ABC estimation of unit costs for emergency department services.

    PubMed

    Holmes, R L; Schroeder, R E

    1996-04-01

    Rapid evolution of the health care industry forces managers to make cost-effective decisions. Typical hospital cost accounting systems do not provide emergency department managers with the information needed, but emergency department settings are so complex and dynamic as to make the more accurate activity-based costing (ABC) system prohibitively expensive. Through judicious use of the available traditional cost accounting information and simple computer spreadsheets. managers may approximate the decision-guiding information that would result from the much more costly and time-consuming implementation of ABC. PMID:10156656

  2. Member satisfaction information as competitive intelligence: a new tool for increasing market share and reducing costs.

    PubMed

    Cooperman, T

    1995-01-01

    MCOs have begun to realize the impact that consumer satisfaction has on enrollment and pricing. Taking a lesson from auto manufacturers, MCOs are now realizing the additional advantages of obtaining consumer satisfaction information about their competitors. Knowing competitors' members intentions to stay or leave their plans, pin-pointing competitors' strengths and weaknesses, and identifying unmet consumer needs, allow MCOs to more successfully develop tactics and strategies for sales, marketing, and planning. This article describes the use of member satisfaction information as competitive intelligence, what to look for in this information, and sources for obtaining reliable information. PMID:10151593

  3. 75 FR 76080 - Agency Information Collection (Claim for Payment of Cost of Unauthorized Medical Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... submit the collection of information abstracted below to the Office of Management and Budget (OMB) for... Control No. 2900-0080'' in any correspondence. FOR FURTHER INFORMATION CONTACT: Denise McLamb, Enterprise... the Secretary. Denise McLamb, Program Analyst, Enterprise Records Service. BILLING CODE 8320-01-P...

  4. 76 FR 22410 - Notice of Proposed Information Collection: Comment Request; Mortgagor's Certificate of Actual Cost

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... Federal Information Relay Service, (1-800-877-8339). FOR FURTHER INFORMATION CONTACT: Joyce Allen... of 1995 (44 U.S.C. chapter 35, as amended). This Notice is soliciting comments from members of the... approved collection. Authority: The Paperwork Reduction Act of 1995, 44 U.S.C., Chapter 35, as...

  5. Smart Aquifer Characterisation validated using Information Theory and Cost benefit analysis

    NASA Astrophysics Data System (ADS)

    Moore, Catherine

    2016-04-01

    The field data acquisition required to characterise aquifer systems are time consuming and expensive. Decisions regarding field testing, the type of field measurements to make and the spatial and temporal resolution of measurements have significant cost repercussions and impact the accuracy of various predictive simulations. The Smart Aquifer Characterisation (SAC) research programme (New Zealand (NZ)) addresses this issue by assembling and validating a suite of innovative methods for characterising groundwater systems at the large, regional and national scales. The primary outcome is a suite of cost effective tools and procedures provided to resource managers to advance the understanding and management of groundwater systems and thereby assist decision makers and communities in the management of their groundwater resources, including the setting of land use limits that protect fresh water flows and quality and the ecosystems dependent on that fresh water. The programme has focused novel investigation approaches including the use of geophysics, satellite remote sensing, temperature sensing and age dating. The SMART (Save Money And Reduce Time) aspect of the programme emphasises techniques that use these passive cost effective data sources to characterise groundwater systems at both the aquifer and the national scale by: • Determination of aquifer hydraulic properties • Determination of aquifer dimensions • Quantification of fluxes between ground waters and surface water • Groundwater age dating These methods allow either a lower cost method for estimating these properties and fluxes, or a greater spatial and temporal coverage for the same cost. To demonstrate the cost effectiveness of the methods a 'data worth' analysis is undertaken. The data worth method involves quantification of the utility of observation data in terms of how much it reduces the uncertainty of model parameters and decision focussed predictions which depend on these parameters. Such

  6. Smart Aquifer Characterisation validated using Information Theory and Cost benefit analysis

    NASA Astrophysics Data System (ADS)

    Moore, Catherine

    2016-04-01

    The field data acquisition required to characterise aquifer systems are time consuming and expensive. Decisions regarding field testing, the type of field measurements to make and the spatial and temporal resolution of measurements have significant cost repercussions and impact the accuracy of various predictive simulations. The Smart Aquifer Characterisation (SAC) research programme (New Zealand (NZ)) addresses this issue by assembling and validating a suite of innovative methods for characterising groundwater systems at the large, regional and national scales. The primary outcome is a suite of cost effective tools and procedures provided to resource managers to advance the understanding and management of groundwater systems and thereby assist decision makers and communities in the management of their groundwater resources, including the setting of land use limits that protect fresh water flows and quality and the ecosystems dependent on that fresh water. The programme has focused novel investigation approaches including the use of geophysics, satellite remote sensing, temperature sensing and age dating. The SMART (Save Money And Reduce Time) aspect of the programme emphasises techniques that use these passive cost effective data sources to characterise groundwater systems at both the aquifer and the national scale by: • Determination of aquifer hydraulic properties • Determination of aquifer dimensions • Quantification of fluxes between ground waters and surface water • Groundwater age dating These methods allow either a lower cost method for estimating these properties and fluxes, or a greater spatial and temporal coverage for the same cost. To demonstrate the cost effectiveness of the methods a 'data worth' analysis is undertaken. The data worth method involves quantification of the utility of observation data in terms of how much it reduces the uncertainty of model parameters and decision focussed predictions which depend on these parameters. Such

  7. Accurate prediction of protein structural classes by incorporating predicted secondary structure information into the general form of Chou's pseudo amino acid composition.

    PubMed

    Kong, Liang; Zhang, Lichao; Lv, Jinfeng

    2014-03-01

    Extracting good representation from protein sequence is fundamental for protein structural classes prediction tasks. In this paper, we propose a novel and powerful method to predict protein structural classes based on the predicted secondary structure information. At the feature extraction stage, a 13-dimensional feature vector is extracted to characterize general contents and spatial arrangements of the secondary structural elements of a given protein sequence. Specially, four segment-level features are designed to elevate discriminative ability for proteins from the α/β and α+β classes. After the features are extracted, a multi-class non-linear support vector machine classifier is used to implement protein structural classes prediction. We report extensive experiments comparing the proposed method to the state-of-the-art in protein structural classes prediction on three widely used low-similarity benchmark datasets: FC699, 1189 and 640. Our method achieves competitive performance on prediction accuracies, especially for the overall prediction accuracies which have exceeded the best reported results on all of the three datasets. PMID:24316044

  8. 78 FR 37883 - Information Collection Activities: Report of Fuel Cost, Consumption, and Surcharge Revenue

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ...As required by the Paperwork Reduction Act of 1995, 44 U.S.C. 3501-3519 (PRA), the Surface Transportation Board (STB or Board) gives notice of its intent to seek from the Office of Management and Budget (OMB) an extension of approval for the collection of the Report of Fuel Cost, Consumption, and Surcharge Revenue. Comments are requested concerning: (1) The accuracy of the Board's burden......

  9. New frac analysis uses real-time information to lower costs, raise

    SciTech Connect

    Aud, W.W.; Middlebrook, M.L.

    1995-08-01

    Evolving hydraulic fracturing technology during the past 10 years has led to reduced costs, improved production and increased cash flow. This report describes several critical aspects in hydraulic fracturing including mechanisms, approaches in treatment quality control procedures and stress profile development, and finally, it is shown how the mechanisms or processes can be addressed and improved through advanced, real-time hydraulic fracture treatment evaluation and execution.

  10. Grading More Accurately

    ERIC Educational Resources Information Center

    Rom, Mark Carl

    2011-01-01

    Grades matter. College grading systems, however, are often ad hoc and prone to mistakes. This essay focuses on one factor that contributes to high-quality grading systems: grading accuracy (or "efficiency"). I proceed in several steps. First, I discuss the elements of "efficient" (i.e., accurate) grading. Next, I present analytical results…

  11. Laboratory computing--process and information management supporting high-quality, cost-effective healthcare.

    PubMed

    Buffone, G J; Moreau, D R

    1995-09-01

    One currently observes many healthcare institutions rushing to reengineer and install information systems with the expectation of achieving enhanced efficiency, competitiveness, and, it is hoped, higher patient satisfaction resulting from timely, high-quality care. Unfortunately, information system concepts, design, and implementation have not yet addressed the complexity of representing and managing clinical processes. As a result, much of the synergy one might expect to derive from understanding and designing clinical processes to gain efficiency and quality while maintaining humanness is not readily achievable by implementing traditional information systems. In this presentation, with laboratory services as an example, we describe a conceptually different information systems model, which we believe would aid care-givers in their efforts to deliver compassionate, quality care while addressing the highly competitive nature of market-driven healthcare. PMID:7656450

  12. Impact of information cost and switching of trading strategies in an artificial stock market

    NASA Astrophysics Data System (ADS)

    Liu, Yi-Fang; Zhang, Wei; Xu, Chao; Vitting Andersen, Jørgen; Xu, Hai-Chuan

    2014-08-01

    This paper studies the switching of trading strategies and its effect on the market volatility in a continuous double auction market. We describe the behavior when some uninformed agents, who we call switchers, decide whether or not to pay for information before they trade. By paying for the information they behave as informed traders. First we verify that our model is able to reproduce some of the stylized facts in real financial markets. Next we consider the relationship between switching and the market volatility under different structures of investors. We find that there exists a positive relationship between the market volatility and the percentage of switchers. We therefore conclude that the switchers are a destabilizing factor in the market. However, for a given fixed percentage of switchers, the proportion of switchers that decide to buy information at a given moment of time is negatively related to the current market volatility. In other words, if more agents pay for information to know the fundamental value at some time, the market volatility will be lower. This is because the market price is closer to the fundamental value due to information diffusion between switchers.

  13. U.S. Geological Survey Streamgage Operation and Maintenance Cost Evaluation...from the National Streamflow Information Program

    USGS Publications Warehouse

    Norris, J. Michael

    2010-01-01

    To help meet the goal of providing earth-science information to the Nation, the U.S. Geological Survey (USGS) operates and maintains the largest streamgage network in the world, with over 7,600 active streamgages in 2010. This network is operated in cooperation with over 850 Federal, tribal, State, and local funding partners. The streamflow information provided by the USGS is used for the protection of life and property; for the assessment, allocation, and management of water resources; for the design of roads, bridges, dams, and water works; for the delineation of flood plains; for the assessment and evaluation of habitat; for understanding the effects of land-use, water-use, and climate changes; for evaluation of water quality; and for recreational safety and enjoyment. USGS streamgages are managed and operated to rigorous national standards, allowing analyses of data from streamgages in different areas and spanning long time periods, some with more than 100 years of data. About 90 percent of USGS streamgages provide streamflow information real-time on the web. Physical measurements of streamflow are made at streamgages multiple times a year, depending on flow conditions, to ensure the highest level of accuracy possible. In addition, multiple reviews and quality assurance checks are performed before the data is finalized. In 2006, the USGS reviewed all activities, operations, equipment, support, and costs associated with operating and maintaining a streamgage program (Norris and others, 2008). A summary of the percentages of costs associated with activities required to operate a streamgage on an annual basis are presented in figure 1. This information represents what it costs to fund a 'typical' USGS streamgage and how those funds are utilized. It should be noted that some USGS streamgages have higher percentages for some categories than do others depending on location and conditions. Forty-one percent of the funding for the typical USGS streamgage is for labor

  14. Prognostic testing in coronary artery disease: An analysis of the relationship between increments in cost and information

    SciTech Connect

    Pollock, B.H.

    1988-01-01

    Tests analyzed include stress electrocardiography (ECG), thallium myocardial perfusion scintigraphy, and technetium wall motion scintigraphy. The incremental value of each test was evaluated using staged survival regression and was measured as the area under the receiver operating characteristic (ROC) curve. This approach is preferable to one based on sensitivity and specificity derived from heterogeneous populations, or from approaches that report the most powerful predictor obtained from stepwise regression. Cost-effectiveness for each test was assessed as the increment of ROC area divided by the marginal cost. Three populations were studied. In the thallium population, a significant increment in ROC area was added at each stage of testing; more prognostic information was added by ECG than by thallium. In the technetium population, ECG added a significant increment of ROC area, but technetium did not. In the population receiving both nuclear, more incremental information was added by thallium than by technetium. Thallium was found to be more cost-effective than technetium; thus, it is preferred for assessing prognosis in patients with suspected disease.

  15. Benefit-cost analysis with uncertain information: an application in air pollution control

    SciTech Connect

    Ruby, M.G.

    1981-01-01

    This dissertation develops and demonstrates a form of the net present value decision rule for evaluating the economic advisability of air pollution control policies and projects. It follows a line of argument advanced by earlier authors to derive a formulation of the net present value rule that discounts future benefits and costs at the social rate of time preference but accounts for the lost opportunity costs of the higher returns available to private investments. Using this form, it explores the uncertainties in the resulting calculations, due to inadequate data, for an air pollution control project at a model stationary source of sulfur dioxide air emissions. It examines each of the variables in the rule for both a meso-scale and a long-range transport cast at three levels of background pollutant concentrations. Estimates are given for both the dominance of the variables at specific nominal values and the uncertainty in the individual terms. Detailed reviews are presented of the various financial, effects, and value variables required by the benefit-cost calculation for the model project. The value of an improvement in visibility from a reduction in sulfate particulate matter is calculated for both cases and each background concentration. The economic value of the reduction of ''regional haze'' was found to be greater than the value associated with reducing ''plume blight'' in even the low background case. The calculations of the relative importance and the relative contributions to uncertainty of the different variables gave similar results. Among the more important terms were the pollution estimates from the dispersion model, the value of (the change in risk of) morbidity, the dose-response functions and the thresholds for morbidity, and the financial terms, such as rates of interest. (JMT)

  16. Cost goals

    NASA Technical Reports Server (NTRS)

    Hoag, J.

    1981-01-01

    Cost goal activities for the point focusing parabolic dish program are reported. Cost goals involve three tasks: (1) determination of the value of the dish systems to potential users; (2) the cost targets of the dish system are set out; (3) the value side and cost side are integrated to provide information concerning the potential size of the market for parabolic dishes. The latter two activities are emphasized.

  17. Accurate monotone cubic interpolation

    NASA Technical Reports Server (NTRS)

    Huynh, Hung T.

    1991-01-01

    Monotone piecewise cubic interpolants are simple and effective. They are generally third-order accurate, except near strict local extrema where accuracy degenerates to second-order due to the monotonicity constraint. Algorithms for piecewise cubic interpolants, which preserve monotonicity as well as uniform third and fourth-order accuracy are presented. The gain of accuracy is obtained by relaxing the monotonicity constraint in a geometric framework in which the median function plays a crucial role.

  18. Accurate Finite Difference Algorithms

    NASA Technical Reports Server (NTRS)

    Goodrich, John W.

    1996-01-01

    Two families of finite difference algorithms for computational aeroacoustics are presented and compared. All of the algorithms are single step explicit methods, they have the same order of accuracy in both space and time, with examples up to eleventh order, and they have multidimensional extensions. One of the algorithm families has spectral like high resolution. Propagation with high order and high resolution algorithms can produce accurate results after O(10(exp 6)) periods of propagation with eight grid points per wavelength.

  19. Optimal Mandates and The Welfare Cost of Asymmetric Information: Evidence from The U.K. Annuity Market*

    PubMed Central

    Einav, Liran; Finkelstein, Amy; Schrimpf, Paul

    2009-01-01

    Much of the extensive empirical literature on insurance markets has focused on whether adverse selection can be detected. Once detected, however, there has been little attempt to quantify its welfare cost, or to assess whether and what potential government interventions may reduce these costs. To do so, we develop a model of annuity contract choice and estimate it using data from the U.K. annuity market. The model allows for private information about mortality risk as well as heterogeneity in preferences over different contract options. We focus on the choice of length of guarantee among individuals who are required to buy annuities. The results suggest that asymmetric information along the guarantee margin reduces welfare relative to a first best symmetric information benchmark by about £127 million per year, or about 2 percent of annuitized wealth. We also find that by requiring that individuals choose the longest guarantee period allowed, mandates could achieve the first-best allocation. However, we estimate that other mandated guarantee lengths would have detrimental effects on welfare. Since determining the optimal mandate is empirically difficult, our findings suggest that achieving welfare gains through mandatory social insurance may be harder in practice than simple theory may suggest. PMID:20592943

  20. A Costing Model for Project-Based Information and Communication Technology Systems

    ERIC Educational Resources Information Center

    Stewart, Brian; Hrenewich, Dave

    2009-01-01

    A major difficulty facing IT departments is ensuring that the projects and activities to which information and communications technologies (ICT) resources are committed represent an effective, economic, and efficient use of those resources. This complex problem has no single answer. To determine effective use requires, at the least, a…

  1. 78 FR 77432 - Proposed Information Collection; Comment Request; Bait and Tackle Store Cost-Earnings Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ...The Department of Commerce, as part of its continuing effort to reduce paperwork and respondent burden, invites the general public and other Federal agencies to take this opportunity to comment on proposed and/or continuing information collections, as required by the Paperwork Reduction Act of...

  2. Executive Information Systems for Total Quality Management: Balancing Quality Improvement and Cost Containment.

    ERIC Educational Resources Information Center

    Glover, Robert H.

    1993-01-01

    In college administration, a climate for adaptive change should be created using the philosophy, processes, and tools of Total Quality Management in combination with other management innovations. An enterprise-wide infrastructure for distributing information on demand for decision makers to monitor institutional performance should be built.…

  3. 76 FR 26705 - Proposed Information Collection; Comment Request; Commercial Fishing Vessel Cost and Earnings...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Environmental Policy Act, Executive Order 12866 and the Regulatory Flexibility Act. The Social Sciences Branch (SSB) of the NMFS, Northeast Fisheries Science Center (NEFSC) is responsible for estimating the economic and social impacts of fishery management actions. Lack of information on vessel operating...

  4. Information-Seeking in Family Day Care: Access, Quality and Personal Cost

    ERIC Educational Resources Information Center

    Corr, L.; Davis, E.; Cook, K.; Mackinnon, A.; Sims, M.; Herrman, H.

    2014-01-01

    Family day-care (FDC) educators work autonomously to provide care and education for children of mixed ages, backgrounds and abilities. To meet the demands and opportunities of their work and regulatory requirements, educators need access to context-relevant and high quality information. No previous research has examined how and where these workers…

  5. Information Technology Cost Center Employee Perception of Their Contribution Value in a For Profit Organizational Culture

    ERIC Educational Resources Information Center

    Gilstrap, Donald E.

    2010-01-01

    A literature review revealed a lack of academic research related to cultural dynamics within organizations that influence information technology investments. The goal of this single descriptive case study of a for profit international company was to examine one area of cultural influence on investments. The aim was to gain an understanding of…

  6. Which University? A Study of the Influence of Cost and Information Factors on Scottish Undergraduate Choice

    ERIC Educational Resources Information Center

    Briggs, Senga; Wilson, Alex

    2007-01-01

    At a time when higher education institutions (HEIs) around the globe face declining student numbers and decreasing funding grants, it becomes imperative for those involved in the recruitment process to understand the factors utilized by students in the search process. This paper explores the influence of two such factors: Information Supplied by…

  7. Codes, Costs, and Critiques: The Organization of Information in "Library Quarterly", 1931-2004

    ERIC Educational Resources Information Center

    Olson, Hope A.

    2006-01-01

    This article reports the results of a quantitative and thematic content analysis of the organization of information literature in the "Library Quarterly" ("LQ") between its inception in 1931 and 2004. The majority of articles in this category were published in the first half of "LQ's" run. Prominent themes have included cataloging codes and the…

  8. 78 FR 40696 - Proposed Information Collection; Comment Request; Alaska Crab Cost Recovery

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ...The Department of Commerce, as part of its continuing effort to reduce paperwork and respondent burden, invites the general public and other Federal agencies to take this opportunity to comment on proposed and/or continuing information collections, as required by the Paperwork Reduction Act of...

  9. Epa evaluation of the petro-mizer device under section 511 of the motor vehicle information and cost savings act

    SciTech Connect

    Barth, E.A.

    1982-12-01

    This document announces the conclusions of the EPA evaluation of the 'PETRO-MIZER' device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the 'PETRO-MIZER' device was conducted upon receiving an application for evaluation by the marketer. The 'PETRO-MIZER' is a device when used in a fuel line leading to the engine of an automobile or truck, results in improved fuel efficiency and reduction in the amounts of polluting emissions. EPA fully considered all of the information submitted by the applicant. The authors have concluded there is no technical basis to justify an EPA confirmatory test program on the device or to expect that the device would improve either emissions or fuel economy.

  10. Developing Information on Energy Savings and Associated Costs and Benefits of Energy Efficient Emerging Technologies Applicable in California

    SciTech Connect

    Xu, Tengfang; Slaa, Jan Willem; Sathaye, Jayant

    2010-12-15

    Implementation and adoption of efficient end-use technologies have proven to be one of the key measures for reducing greenhouse gas (GHG) emissions throughout the industries. In many cases, implementing energy efficiency measures is among one of the most cost effective investments that the industry could make in improving efficiency and productivity while reducing carbon dioxide (CO2) emissions. Over the years, there have been incentives to use resources and energy in a cleaner and more efficient way to create industries that are sustainable and more productive. With the working of energy programs and policies on GHG inventory and regulation, understanding and managing the costs associated with mitigation measures for GHG reductions is very important for the industry and policy makers around the world and in California. Successful implementation of applicable emerging technologies not only may help advance productivities, improve environmental impacts, or enhance industrial competitiveness, but also can play a significant role in climate-mitigation efforts by saving energy and reducing the associated GHG emissions. Developing new information on costs and savings benefits of energy efficient emerging technologies applicable in California market is important for policy makers as well as the industries. Therefore, provision of timely evaluation and estimation of the costs and energy savings potential of emerging technologies applicable to California is the focus of this report. The overall goal of the project is to identify and select a set of emerging and under-utilized energy-efficient technologies and practices as they are important to reduce energy consumption in industry while maintaining economic growth. Specifically, this report contains the results from performing Task 3 Technology Characterization for California Industries for the project titled Research Opportunities in Emerging and Under-Utilized Energy-Efficient Industrial Technologies, sponsored by

  11. Accurate pointing of tungsten welding electrodes

    NASA Technical Reports Server (NTRS)

    Ziegelmeier, P.

    1971-01-01

    Thoriated-tungsten is pointed accurately and quickly by using sodium nitrite. Point produced is smooth and no effort is necessary to hold the tungsten rod concentric. The chemically produced point can be used several times longer than ground points. This method reduces time and cost of preparing tungsten electrodes.

  12. Using architecture information and real-time resource state to reduce power consumption and communication costs in parallel applications.

    SciTech Connect

    Brandt, James M.; Devine, Karen Dragon; Gentile, Ann C.; Leung, Vitus Joseph; Olivier, Stephen Lecler; Pedretti, Kevin; Rajamanickam, Sivasankaran; Bunde, David P.; Deveci, Mehmet; Catalyurek, Umit V.

    2014-09-01

    As computer systems grow in both size and complexity, the need for applications and run-time systems to adjust to their dynamic environment also grows. The goal of the RAAMP LDRD was to combine static architecture information and real-time system state with algorithms to conserve power, reduce communication costs, and avoid network contention. We devel- oped new data collection and aggregation tools to extract static hardware information (e.g., node/core hierarchy, network routing) as well as real-time performance data (e.g., CPU uti- lization, power consumption, memory bandwidth saturation, percentage of used bandwidth, number of network stalls). We created application interfaces that allowed this data to be used easily by algorithms. Finally, we demonstrated the benefit of integrating system and application information for two use cases. The first used real-time power consumption and memory bandwidth saturation data to throttle concurrency to save power without increasing application execution time. The second used static or real-time network traffic information to reduce or avoid network congestion by remapping MPI tasks to allocated processors. Results from our work are summarized in this report; more details are available in our publications [2, 6, 14, 16, 22, 29, 38, 44, 51, 54].

  13. Digital Avionics Information System (DAIS): Life Cycle Cost Impact Modeling System Reliability, Maintainability, and Cost Model (RMCM)--Description. Users Guide. Final Report.

    ERIC Educational Resources Information Center

    Goclowski, John C.; And Others

    The Reliability, Maintainability, and Cost Model (RMCM) described in this report is an interactive mathematical model with a built-in sensitivity analysis capability. It is a major component of the Life Cycle Cost Impact Model (LCCIM), which was developed as part of the DAIS advanced development program to be used to assess the potential impacts…

  14. ESTIMATING IRRIGATION COSTS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Having accurate estimates of the cost of irrigation is important when making irrigation decisions. Estimates of fixed costs are critical for investment decisions. Operating cost estimates can assist in decisions regarding additional irrigations. This fact sheet examines the costs associated with ...

  15. GME: at what cost?

    PubMed

    Young, David W

    2003-11-01

    Current computing methods impede determining the real cost of graduate medical education. However, a more accurate estimate could be obtained if policy makers would allow for the application of basic cost-accounting principles, including consideration of department-level costs, unbundling of joint costs, and other factors. PMID:14626704

  16. A New Activity-Based Financial Cost Management Method

    NASA Astrophysics Data System (ADS)

    Qingge, Zhang

    The standard activity-based financial cost management model is a new model of financial cost management, which is on the basis of the standard cost system and the activity-based cost and integrates the advantages of the two. It is a new model of financial cost management with more accurate and more adequate cost information by taking the R&D expenses as the accounting starting point and after-sale service expenses as the terminal point and covering the whole producing and operating process and the whole activities chain and value chain aiming at serving the internal management and decision.

  17. Using Cost-Effectiveness Tests to Design CHP Incentive Programs

    SciTech Connect

    Tidball, Rick

    2014-11-01

    This paper examines the structure of cost-effectiveness tests to illustrate how they can accurately reflect the costs and benefits of CHP systems. This paper begins with a general background discussion on cost-effectiveness analysis of DER and then describes how cost-effectiveness tests can be applied to CHP. Cost-effectiveness results are then calculated and analyzed for CHP projects in five states: Arkansas, Colorado, Iowa, Maryland, and North Carolina. Based on the results obtained for these five states, this paper offers four considerations to inform regulators in the application of cost-effectiveness tests in developing CHP programs.

  18. Accurate measurement of time

    NASA Astrophysics Data System (ADS)

    Itano, Wayne M.; Ramsey, Norman F.

    1993-07-01

    The paper discusses current methods for accurate measurements of time by conventional atomic clocks, with particular attention given to the principles of operation of atomic-beam frequency standards, atomic hydrogen masers, and atomic fountain and to the potential use of strings of trapped mercury ions as a time device more stable than conventional atomic clocks. The areas of application of the ultraprecise and ultrastable time-measuring devices that tax the capacity of modern atomic clocks include radio astronomy and tests of relativity. The paper also discusses practical applications of ultraprecise clocks, such as navigation of space vehicles and pinpointing the exact position of ships and other objects on earth using the GPS.

  19. Accurate quantum chemical calculations

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Langhoff, Stephen R.; Taylor, Peter R.

    1989-01-01

    An important goal of quantum chemical calculations is to provide an understanding of chemical bonding and molecular electronic structure. A second goal, the prediction of energy differences to chemical accuracy, has been much harder to attain. First, the computational resources required to achieve such accuracy are very large, and second, it is not straightforward to demonstrate that an apparently accurate result, in terms of agreement with experiment, does not result from a cancellation of errors. Recent advances in electronic structure methodology, coupled with the power of vector supercomputers, have made it possible to solve a number of electronic structure problems exactly using the full configuration interaction (FCI) method within a subspace of the complete Hilbert space. These exact results can be used to benchmark approximate techniques that are applicable to a wider range of chemical and physical problems. The methodology of many-electron quantum chemistry is reviewed. Methods are considered in detail for performing FCI calculations. The application of FCI methods to several three-electron problems in molecular physics are discussed. A number of benchmark applications of FCI wave functions are described. Atomic basis sets and the development of improved methods for handling very large basis sets are discussed: these are then applied to a number of chemical and spectroscopic problems; to transition metals; and to problems involving potential energy surfaces. Although the experiences described give considerable grounds for optimism about the general ability to perform accurate calculations, there are several problems that have proved less tractable, at least with current computer resources, and these and possible solutions are discussed.

  20. Accurate and Accidental Empathy.

    ERIC Educational Resources Information Center

    Chandler, Michael

    The author offers two controversial criticisms of what are rapidly becoming standard assessment procedures for the measurement of empathic skill. First, he asserts that assessment procedures which attend exclusively to the accuracy with which subjects are able to characterize other people's feelings provide little or no useful information about…

  1. Daily variation in natural disaster casualties: information flows, safety, and opportunity costs in tornado versus hurricane strikes.

    PubMed

    Zahran, Sammy; Tavani, Daniele; Weiler, Stephan

    2013-07-01

    Casualties from natural disasters may depend on the day of the week they strike. With data from the Spatial Hazard Events and Losses Database for the United States (SHELDUS), daily variation in hurricane and tornado casualties from 5,043 tornado and 2,455 hurricane time/place events is analyzed. Hurricane forecasts provide at-risk populations with considerable lead time. Such lead time allows strategic behavior in choosing protective measures under hurricane threat; opportunity costs in terms of lost income are higher during weekdays than during weekends. On the other hand, the lead time provided by tornadoes is near zero; hence tornados generate no opportunity costs. Tornado casualties are related to risk information flows, which are higher during workdays than during leisure periods, and are related to sheltering-in-place opportunities, which are better in permanent buildings like businesses and schools. Consistent with theoretical expectations, random effects negative binomial regression results indicate that tornado events occurring on the workdays of Monday through Thursday are significantly less lethal than tornados that occur on weekends. In direct contrast, and also consistent with theory, the expected count of hurricane casualties increases significantly with weekday occurrences. The policy implications of observed daily variation in tornado and hurricane events are considered. PMID:23126406

  2. Ultra-low-cost 3D gaze estimation: an intuitive high information throughput compliment to direct brain-machine interfaces

    NASA Astrophysics Data System (ADS)

    Abbott, W. W.; Faisal, A. A.

    2012-08-01

    Eye movements are highly correlated with motor intentions and are often retained by patients with serious motor deficiencies. Despite this, eye tracking is not widely used as control interface for movement in impaired patients due to poor signal interpretation and lack of control flexibility. We propose that tracking the gaze position in 3D rather than 2D provides a considerably richer signal for human machine interfaces by allowing direct interaction with the environment rather than via computer displays. We demonstrate here that by using mass-produced video-game hardware, it is possible to produce an ultra-low-cost binocular eye-tracker with comparable performance to commercial systems, yet 800 times cheaper. Our head-mounted system has 30 USD material costs and operates at over 120 Hz sampling rate with a 0.5-1 degree of visual angle resolution. We perform 2D and 3D gaze estimation, controlling a real-time volumetric cursor essential for driving complex user interfaces. Our approach yields an information throughput of 43 bits s-1, more than ten times that of invasive and semi-invasive brain-machine interfaces (BMIs) that are vastly more expensive. Unlike many BMIs our system yields effective real-time closed loop control of devices (10 ms latency), after just ten minutes of training, which we demonstrate through a novel BMI benchmark—the control of the video arcade game ‘Pong’.

  3. Accounting for Heterogeneity in Relative Treatment Effects for Use in Cost-Effectiveness Models and Value-of-Information Analyses.

    PubMed

    Welton, Nicky J; Soares, Marta O; Palmer, Stephen; Ades, Anthony E; Harrison, David; Shankar-Hari, Manu; Rowan, Kathy M

    2015-07-01

    Cost-effectiveness analysis (CEA) models are routinely used to inform health care policy. Key model inputs include relative effectiveness of competing treatments, typically informed by meta-analysis. Heterogeneity is ubiquitous in meta-analysis, and random effects models are usually used when there is variability in effects across studies. In the absence of observed treatment effect modifiers, various summaries from the random effects distribution (random effects mean, predictive distribution, random effects distribution, or study-specific estimate [shrunken or independent of other studies]) can be used depending on the relationship between the setting for the decision (population characteristics, treatment definitions, and other contextual factors) and the included studies. If covariates have been measured that could potentially explain the heterogeneity, then these can be included in a meta-regression model. We describe how covariates can be included in a network meta-analysis model and how the output from such an analysis can be used in a CEA model. We outline a model selection procedure to help choose between competing models and stress the importance of clinical input. We illustrate the approach with a health technology assessment of intravenous immunoglobulin for the management of adult patients with severe sepsis in an intensive care setting, which exemplifies how risk of bias information can be incorporated into CEA models. We show that the results of the CEA and value-of-information analyses are sensitive to the model and highlight the importance of sensitivity analyses when conducting CEA in the presence of heterogeneity. The methods presented extend naturally to heterogeneity in other model inputs, such as baseline risk. PMID:25712447

  4. Expert systems should be more accurate than human experts - Evaluation procedures from human judgment and decisionmaking

    NASA Technical Reports Server (NTRS)

    Levi, Keith

    1989-01-01

    Two procedures for the evaluation of the performance of expert systems are illustrated: one procedure evaluates predictive accuracy; the other procedure is complementary in that it uncovers the factors that contribute to predictive accuracy. Using these procedures, it is argued that expert systems should be more accurate than human experts in two senses. One sense is that expert systems must be more accurate to be cost-effective. Previous research is reviewed and original results are presented which show that simple statistical models typically perform better than human experts for the task of combining evidence from a given set of information sources. The results also suggest the second sense in which expert systems should be more accurate than human experts. They reveal that expert systems should share factors that contribute to human accuracy, but not factors that detract from human accuracy. Thus the thesis is that one should both require and expect systems to be more accurate than humans.

  5. Application of the Activity-Based Costing Method for Unit-Cost Calculation in a Hospital

    PubMed Central

    Javid, Mahdi; Hadian, Mohammad; Ghaderi, Hossein; Ghaffari, Shahram; Salehi, Masoud

    2016-01-01

    Background: Choosing an appropriate accounting system for hospital has always been a challenge for hospital managers. Traditional cost system (TCS) causes cost distortions in hospital. Activity-based costing (ABC) method is a new and more effective cost system. Objective: This study aimed to compare ABC with TCS method in calculating the unit cost of medical services and to assess its applicability in Kashani Hospital, Shahrekord City, Iran. Methods: This cross-sectional study was performed on accounting data of Kashani Hospital in 2013. Data on accounting reports of 2012 and other relevant sources at the end of 2012 were included. To apply ABC method, the hospital was divided into several cost centers and five cost categories were defined: wage, equipment, space, material, and overhead costs. Then activity centers were defined. ABC method was performed into two phases. First, the total costs of cost centers were assigned to activities by using related cost factors. Then the costs of activities were divided to cost objects by using cost drivers. After determining the cost of objects, the cost price of medical services was calculated and compared with those obtained from TCS. Results: The Kashani Hospital had 81 physicians, 306 nurses, and 328 beds with the mean occupancy rate of 67.4% during 2012. Unit cost of medical services, cost price of occupancy bed per day, and cost per outpatient service were calculated. The total unit costs by ABC and TCS were respectively 187.95 and 137.70 USD, showing 50.34 USD more unit cost by ABC method. ABC method represented more accurate information on the major cost components. Conclusion: By utilizing ABC, hospital managers have a valuable accounting system that provides a true insight into the organizational costs of their department. PMID:26234974

  6. Lonely at the top and stuck in the middle? The ongoing challenge of using cost-effectiveness information in priority setting

    PubMed Central

    Williams, Iestyn; Bryan, Stirling

    2015-01-01

    The topic of how cost-effectiveness information informs priority setting in healthcare remains important to both policy and practice. This commentary considers the study carried out by Eckard and colleagues in Sweden. In it we distinguish between the conditions at national and local levels and put forward some recommendations for research into local priority setting in particular. PMID:25774376

  7. 32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false DD Form 2086-1, âRecord of Freedom of Information (FOI) Processing Cost for Technical Dataâ D Appendix D to Part 286 National Defense Department of... FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form...

  8. 32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false DD Form 2086-1, âRecord of Freedom of Information (FOI) Processing Cost for Technical Dataâ D Appendix D to Part 286 National Defense Department of... FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form...

  9. 32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false DD Form 2086-1, âRecord of Freedom of Information (FOI) Processing Cost for Technical Dataâ D Appendix D to Part 286 National Defense Department of... FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form...

  10. Business models for cost effective use of health information technologies: lessons learned in the CHCS II project.

    PubMed

    Riley, David L

    2003-01-01

    The Department of Defense (DoD) has embarked on an initiative to create an electronic medical record for all of its eligible beneficiaries. The Clinical Information Technology Program Office (CITPO) is the joint-service program office established to centrally manage this multi-year project. The Composite Health Care System II (CHCS II) is the name of the system under development. Given the historical failure rate of large-scale government information system projects, CITPO has employed an incremental acquisition approach and striven to use industry best practices to the greatest degree possible within the constraints of federal acquisition law. Based on lessons learned during the concept exploration phase of this project, CITPO, in partnership with Integic Corporation, the prime integration contractor, has reengineered its software acquisition process to include industry best practices. The result of this reengineering process has resulted in a reduction of the total projected life cycle costs for CHCS II from the original estimate of $7.6 billion over a 14-year period to between $3.9 and $4.3 billion. PMID:15455852

  11. A new low-cost, fully fault-protected PWM-VSI inverter with true phase-current information

    SciTech Connect

    Blaabjerg, F.; Pedersen, J.K.

    1997-01-01

    This paper proposes a new topology for a low-cost three-phase pulse width modulation (PWM) VSI inverter where a true phase current information exists with the use of only one current sensor in the dc link. The topology also has the benefits of full protection of the inverter such as short circuits in the dc link, output phase faults, and output earth faults. Previously suggested methods have problems at low speed in detecting the phase current, but by the use of space vector modulation in a double-sided implementation, the PWM-pulses are adjusted so true information about the phase current exists even at very low speed. The dc link current is sampled twice during one switching period, and it is proposed to sample in the center of the PWM-pulses to obtain a real average phase current. The effects of blanking-time and overmodulation are also discussed. The strategy is implemented in a 16-b microcontroller, and the test results show the technique is useful in the whole speed range. It is concluded by the use of the proposed topology that only one current sensor will be necessary in the future for PWM-VSI inverters.

  12. Principles and methods of managerial cost-accounting systems.

    PubMed

    Suver, J D; Cooper, J C

    1988-01-01

    An introduction to cost-accounting systems for pharmacy managers is provided; terms are defined and examples of specific applications are given. Cost-accounting systems determine, record, and report the resources consumed in providing services. An effective cost-accounting system must provide the information needed for both internal and external reports. In accounting terms, cost is the value given up to secure an asset. In determining how volumes of activity affect costs, fixed costs and variable costs are calculated; applications include pricing strategies, cost determinations, and break-even analysis. Also discussed are the concepts of direct and indirect costs, opportunity costs, and incremental and sunk costs. For most pharmacy department services, process costing, an accounting of intermediate outputs and homogeneous units, is used; in determining the full cost of providing a product or service (e.g., patient stay), job-order costing is used. Development of work-performance standards is necessary for monitoring productivity and determining product costs. In allocating pharmacy department costs, a ratio of costs to charges can be used; this method is convenient, but microcosting (specific identification of the costs of products) is more accurate. Pharmacy managers can use cost-accounting systems to evaluate the pharmacy's strategies, policies, and services and to improve budgets and reports. PMID:3348229

  13. Cost-Effectiveness of Colorectal Cancer Screening in High Risk Spanish Patients: Use of a Validated Model to Inform Public Policy

    PubMed Central

    Ladabaum, Uri; Ferrandez, Angel; Lanas, Angel I.

    2011-01-01

    Background The European Community has made a commitment to colorectal cancer (CRC) screening, but regional considerations may affect the design of national screening programs. We developed a decision analytic model tailored to a pilot screening program for high risk persons in Spain with the aim of informing public policy decisions. Methods We constructed a decision analytic Markov model based on our validated model of CRC screening that reflected CRC epidemiology and costs in persons with first-degree relatives with CRC in Aragón, Spain, and superimposed colonoscopy every 5 or 10 years from ages 40-80 years. The pilot program’s preliminary clinical results and our modeling results were presented to regional health authorities. Results In the model, without screening, 88 CRC cases occurred per 1,000 persons from age 40-85 years. In the base case, screening reduced this by 72-77% and gained 0.12 discounted life-years/person. Screening every 10 years was cost-saving, and screening every 5 years vs. every 10 years cost 7,250 €/life-year gained. Based on these savings, 36-39 €/person/year could go towards operating costs while maintaining a neutral budget. If screening costs doubled, screening remained highly cost-effective, but no longer cost-saving. These results contributed to the health authorities’ decision to expand the pilot program to the entire region in 2009. Conclusions Colonoscopic screening of first-degree relatives of persons with CRC may be cost-saving in public systems like Spain’s. Decision analytic modeling tailored to regional considerations can inform public policy decisions. Impact Tailored decision analytic modeling can inform regional policy decisions on cancer screening. PMID:20810603

  14. An Analysis of Rocket Propulsion Testing Costs

    NASA Technical Reports Server (NTRS)

    Ramirez, Carmen; Rahman, Shamim

    2010-01-01

    The primary mission at NASA Stennis Space Center (SSC) is rocket propulsion testing. Such testing is commonly characterized as one of two types: production testing for certification and acceptance of engine hardware, and developmental testing for prototype evaluation or research and development (R&D) purposes. For programmatic reasons there is a continuing need to assess and evaluate the test costs for the various types of test campaigns that involve liquid rocket propellant test articles. Presently, in fact, there is a critical need to provide guidance on what represents a best value for testing and provide some key economic insights for decision-makers within NASA and the test customers outside the Agency. Hence, selected rocket propulsion test databases and references have been evaluated and analyzed with the intent to discover correlations of technical information and test costs that could help produce more reliable and accurate cost projections in the future. The process of searching, collecting, and validating propulsion test cost information presented some unique obstacles which then led to a set of recommendations for improvement in order to facilitate future cost information gathering and analysis. In summary, this historical account and evaluation of rocket propulsion test cost information will enhance understanding of the various kinds of project cost information; identify certain trends of interest to the aerospace testing community.

  15. Public Perceptions of Regulatory Costs, Their Uncertainty and Interindividual Distribution.

    PubMed

    Johnson, Branden B; Finkel, Adam M

    2016-06-01

    Public perceptions of both risks and regulatory costs shape rational regulatory choices. Despite decades of risk perception studies, this article is the first on regulatory cost perceptions. A survey of 744 U.S. residents probed: (1) How knowledgeable are laypeople about regulatory costs incurred to reduce risks? (2) Do laypeople see official estimates of cost and benefit (lives saved) as accurate? (3) (How) do preferences for hypothetical regulations change when mean-preserving spreads of uncertainty replace certain cost or benefit? and (4) (How) do preferences change when unequal interindividual distributions of hypothetical regulatory costs replace equal distributions? Respondents overestimated costs of regulatory compliance, while assuming agencies underestimate costs. Most assumed agency estimates of benefits are accurate; a third believed both cost and benefit estimates are accurate. Cost and benefit estimates presented without uncertainty were slightly preferred to those surrounded by "narrow uncertainty" (a range of costs or lives entirely within a personally-calibrated zone without clear acceptance or rejection of tradeoffs). Certain estimates were more preferred than "wide uncertainty" (a range of agency estimates extending beyond these personal bounds, thus posing a gamble between favored and unacceptable tradeoffs), particularly for costs as opposed to benefits (but even for costs a quarter of respondents preferred wide uncertainty to certainty). Agency-acknowledged uncertainty in general elicited mixed judgments of honesty and trustworthiness. People preferred egalitarian distributions of regulatory costs, despite skewed actual cost distributions, and preferred progressive cost distributions (the rich pay a greater than proportional share) to regressive ones. Efficient and socially responsive regulations require disclosure of much more information about regulatory costs and risks. PMID:26742683

  16. Low-Cost Sensors Deliver Nanometer-Accurate Measurements

    NASA Technical Reports Server (NTRS)

    2015-01-01

    As part of a unique partnership program, Kennedy Space Center collaborated with a nearby business school to allow MBA students to examine and analyze the market potential for a selection of NASA-patented technologies. Following the semester, a group of students decided to form Winter Park, Florida-based Juntura Group Inc. to license and sell a technology they had worked with: a sensor capable of detecting position changes as small as 10 nanometers-approximately the thickness of a cell wall.

  17. Exploring Cost Exchange at Colleges and Universities. A Report on the 1973 Field Test of NCHEMS' Preliminary Information Exchange and Reporting Procedures at 70 Institutions.

    ERIC Educational Resources Information Center

    Collard, William; Huff, Robert

    The Preliminary Information Exchange Procedures (IEP) cost study project was undertaken as a joint venture by a group of colleges and universities and the National Center for Higher Education Management Systems (NCHEMS). The project was initiated and sponsored by NCHEMS to accomplish six objectives that would benefit both the institutions and…

  18. EPA (Environmental Protection Agency) evaluation of the HYDRO-VAC device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1983-08-01

    This document announces the conclusions of the EPA evaluation of the HYDRO-VAC device under section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the HYDRO-VAC device was conducted upon the application of the manufacturer. The product is claimed to improved fuel economy and performance for both gasoline and diesel fueled vehicles.

  19. EPA evaluation of the SYNERGY-1 fuel additive under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1981-06-01

    This document announces the conclusions of the EPA evaluation of the 'SYNERGY-1' device under provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. This additive is intended to improve fuel economy and exhaust emission levels of two and four cycle gasoline fueled engines.

  20. Toxic Substances: Information on Costs and Financial Aid to Schools To Control Asbestos. Fact Sheet for the Honorable John J. La Falce, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Resources, Community, and Economic Development Div.

    Information on the costs of and financial aid available to schools for asbestos abatement is provided in this report. Data are based on interviews with officials from 15 school districts in 5 states--Illinois, New Jersey, New York, Ohio, and Pennsylvania. Section 1 provides background on the use of asbestos in buildings, health problems, federal…

  1. How Do Students Meet the Cost of Attending a State University? Information Brief. Volume 4, Issue 2

    ERIC Educational Resources Information Center

    Florida Board of Governors, State University System, 2007

    2007-01-01

    Students and their families must cover, on average, 83% of the roughly $16,000 cost of attendance for a full-time, in-state undergraduate at a state university in Florida. On average, 75% of the cost of attendance in Florida's public universities is from expenses other than tuition and fees and books. The largest expense is room and board,…

  2. Digital Avionics Information System (DAIS): Life Cycle Cost Impact Modeling System (LCCIM)--A Managerial Overview. Final Report.

    ERIC Educational Resources Information Center

    Goclowski, John C.; Baran, H. Anthony

    This report gives a managerial overview of the Life Cycle Cost Impact Modeling System (LCCIM), which was designed to provide the Air Force with an in-house capability of assessing the life cycle cost impact of weapon system design alternatives. LCCIM consists of computer programs and the analyses which the user must perform to generate input data.…

  3. EPA (Environmental Protection Agency) evaluation of the Cyclone-Z device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1983-01-01

    This document announces the conclusions of the EPA evaluation of the Cyclone-Z device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Cyclone-Z device was conducted upon receiving an application from the marketer. The device is claimed to improve fuel economy and driveability and to reduce exhaust emissions. EPA fully considered all of the information submitted by the applicant. The evaluation of the Cyclone-Z device was based on that information, EPA's engineering judgement, and its experience with other air bleed devices.

  4. The Psychology of Cost Estimating

    NASA Technical Reports Server (NTRS)

    Price, Andy

    2016-01-01

    Cost estimation for large (and even not so large) government programs is a challenge. The number and magnitude of cost overruns associated with large Department of Defense (DoD) and National Aeronautics and Space Administration (NASA) programs highlight the difficulties in developing and promulgating accurate cost estimates. These overruns can be the result of inadequate technology readiness or requirements definition, the whims of politicians or government bureaucrats, or even as failures of the cost estimating profession itself. However, there may be another reason for cost overruns that is right in front of us, but only recently have we begun to grasp it: the fact that cost estimators and their customers are human. The last 70+ years of research into human psychology and behavioral economics have yielded amazing findings into how we humans process and use information to make judgments and decisions. What these scientists have uncovered is surprising: humans are often irrational and illogical beings, making decisions based on factors such as emotion and perception, rather than facts and data. These built-in biases to our thinking directly affect how we develop our cost estimates and how those cost estimates are used. We cost estimators can use this knowledge of biases to improve our cost estimates and also to improve how we communicate and work with our customers. By understanding how our customers think, and more importantly, why they think the way they do, we can have more productive relationships and greater influence. By using psychology to our advantage, we can more effectively help the decision maker and our organizations make fact-based decisions.

  5. Environmental Protection Agency evaluation of the AUTOTHERM Energy Conservation System under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Pidgeon, W.M.

    1985-01-01

    The document announces the conclusions of the EPA evaluation of the AUTOTHERM Energy Conservation System device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the AUTOTHERM Energy Conservation System was conducted upon the application of the manufacturer. The device allows using the vehicle's heater while parked with the engine off. Using the device is claimed to: (1) conserve fuel, (2) eliminate the exhaust pollutants that are generated when vehicle warmth is maintained by idling the engine, and, (3) lower maintenance costs. The device is also claimed to improve safety by eliminating the need to leave an unattended vehicle with its engine idling to maintain warmth. Carbon monoxide poisoning risks are also alleviated. EPA fully considered all of the information submitted by the applicant. The evaluation of the AUTOTHERM Energy Conservation System was based on that information and the results of an Air Force test project.

  6. Accurate modeling of parallel scientific computations

    NASA Technical Reports Server (NTRS)

    Nicol, David M.; Townsend, James C.

    1988-01-01

    Scientific codes are usually parallelized by partitioning a grid among processors. To achieve top performance it is necessary to partition the grid so as to balance workload and minimize communication/synchronization costs. This problem is particularly acute when the grid is irregular, changes over the course of the computation, and is not known until load time. Critical mapping and remapping decisions rest on the ability to accurately predict performance, given a description of a grid and its partition. This paper discusses one approach to this problem, and illustrates its use on a one-dimensional fluids code. The models constructed are shown to be accurate, and are used to find optimal remapping schedules.

  7. COSTS OF URBAN STORMWATER CONTROL

    EPA Science Inventory

    This paper presents information on the cost of stormwater pollution control facilities in urban areas, including collection, control, and treatment systems. Information on prior cost studies of control technologies and cost estimating models used in these studies was collected, r...

  8. NNLOPS accurate associated HW production

    NASA Astrophysics Data System (ADS)

    Astill, William; Bizon, Wojciech; Re, Emanuele; Zanderighi, Giulia

    2016-06-01

    We present a next-to-next-to-leading order accurate description of associated HW production consistently matched to a parton shower. The method is based on reweighting events obtained with the HW plus one jet NLO accurate calculation implemented in POWHEG, extended with the MiNLO procedure, to reproduce NNLO accurate Born distributions. Since the Born kinematics is more complex than the cases treated before, we use a parametrization of the Collins-Soper angles to reduce the number of variables required for the reweighting. We present phenomenological results at 13 TeV, with cuts suggested by the Higgs Cross section Working Group.

  9. PPD-QALY-an index for cost-effectiveness in orthopedics: providing essential information to both physicians and health care policy makers for appropriate allocation of medical resources.

    PubMed

    Dougherty, Christopher P; Howard, Timothy

    2013-09-01

    Because of the increasing health care costs and the need for proper allocation of resources, it is important to ensure the best use of health benefits for sick and injured people of the population. An index or indicator is needed to help us quantify what is being spent so that comparisons with other options can be implemented. Cost-effective analysis seems to be well suited to provide this essential information to health care policy makers and those charged with distributing disability funds so that the proper allocation of resources can be achieved. There is currently no such index to show whether the benefits paid out are the most cost-effective. By comparing the quality-adjusted life year (QALY) of a treatment method to the disability an individual would experience, on the basis of lost wages as measure of disability, we provide decision makers more information for the basis of cost allocation in health care. To accomplish this, we describe a new term, the PPD-QALY (permanent partial disability-quality of life year). This term was developed to establish an index to which musculoskeletal care can be compared, to evaluate the cost-effectiveness of a treatment on the basis of the monetary value of the disability. This term serves to standardize the monetary value of an injury. Cost-effective analysis in arthroscopic surgery may prove to be a valuable asset in this role and to provide decision makers the information needed to determine the societal benefit from new arthroscopic procedures as they are developed and implemented. PMID:23924750

  10. Cost-Effectiveness of HIV Drug Resistance Testing to Inform Switching to Second Line Antiretroviral Therapy in Low Income Settings

    PubMed Central

    Phillips, Andrew; Cambiano, Valentina; Nakagawa, Fumiyo; Magubu, Travor; Miners, Alec; Ford, Debbie; Pillay, Deenan; De Luca, Andrea; Lundgren, Jens; Revill, Paul

    2014-01-01

    Background To guide future need for cheap resistance tests for use in low income settings, we assessed cost-effectiveness of drug resistance testing as part of monitoring of people on first line ART - with switching from first to second line ART being conditional on NNRTI drug resistance mutations being identified. Methods An individual level simulation model of HIV transmission, progression and the effect of ART which accounts for adherence and resistance development was used to compare outcomes of various potential monitoring strategies in a typical low income setting in sub-Saharan Africa. Underlying monitoring strategies considered were based on clinical disease, CD4 count or viral load. Within each we considered a strategy in which no further measures are performed, one with a viral load measure to confirm failure, and one with both a viral load measure and a resistance test. Predicted outcomes were assessed over 2015–2025 in terms of viral suppression, first line failure, switching to second line regimen, death, HIV incidence, disability-adjusted-life-years averted and costs. Potential future low costs of resistance tests ($30) were used. Results The most effective strategy, in terms of DALYs averted, was one using viral load monitoring without confirmation. The incremental cost-effectiveness ratio for this strategy was $2113 (the same as that for viral load monitoring with confirmation). ART monitoring strategies which involved resistance testing did not emerge as being more effective or cost effective than strategies not using it. The slightly reduced ART costs resulting from use of resistance testing, due to less use of second line regimens, was of similar magnitude to the costs of resistance tests. Conclusion Use of resistance testing at the time of first line failure as part of the decision whether to switch to second line therapy was not cost-effective, even though the test was assumed to be very inexpensive. PMID:25290340

  11. How to accurately bypass damage

    PubMed Central

    Broyde, Suse; Patel, Dinshaw J.

    2016-01-01

    Ultraviolet radiation can cause cancer through DNA damage — specifically, by linking adjacent thymine bases. Crystal structures show how the enzyme DNA polymerase η accurately bypasses such lesions, offering protection. PMID:20577203

  12. Accurate Evaluation of Quantum Integrals

    NASA Technical Reports Server (NTRS)

    Galant, David C.; Goorvitch, D.

    1994-01-01

    Combining an appropriate finite difference method with Richardson's extrapolation results in a simple, highly accurate numerical method for solving a Schr\\"{o}dinger's equation. Important results are that error estimates are provided, and that one can extrapolate expectation values rather than the wavefunctions to obtain highly accurate expectation values. We discuss the eigenvalues, the error growth in repeated Richardson's extrapolation, and show that the expectation values calculated on a crude mesh can be extrapolated to obtain expectation values of high accuracy.

  13. Organizational Uses of Health Information Exchange to Change Cost and Utilization Outcomes: A Typology from a Multi-Site Qualitative Analysis

    PubMed Central

    Vest, Joshua R; Abramson, Erika

    2015-01-01

    Health information exchange (HIE) systems facilitate access to patient information for a variety of health care organizations, end users, and clinical and organizational goals. While a complex intervention, organizations’ usage of HIE is often conceptualized and measured narrowly. We sought to provide greater specificity to the concept of HIE as an intervention by formulating a typology of organizational HIE usage. We interviewed representatives of a regional health information organization and health care organizations actively using HIE information to change patient utilization and costs. The resultant typology includes three dimensions: user role, usage initiation, and patient set. This approach to categorizing how health care organizations are actually applying HIE information to clinical and business tasks provides greater clarity about HIE as an intervention and helps elucidate the conceptual linkage between HIE an organizational and patient outcomes. PMID:26958266

  14. Accurate mask model for advanced nodes

    NASA Astrophysics Data System (ADS)

    Zine El Abidine, Nacer; Sundermann, Frank; Yesilada, Emek; Ndiaye, El Hadji Omar; Mishra, Kushlendra; Paninjath, Sankaranarayanan; Bork, Ingo; Buck, Peter; Toublan, Olivier; Schanen, Isabelle

    2014-07-01

    Standard OPC models consist of a physical optical model and an empirical resist model. The resist model compensates the optical model imprecision on top of modeling resist development. The optical model imprecision may result from mask topography effects and real mask information including mask ebeam writing and mask process contributions. For advanced technology nodes, significant progress has been made to model mask topography to improve optical model accuracy. However, mask information is difficult to decorrelate from standard OPC model. Our goal is to establish an accurate mask model through a dedicated calibration exercise. In this paper, we present a flow to calibrate an accurate mask enabling its implementation. The study covers the different effects that should be embedded in the mask model as well as the experiment required to model them.

  15. Cost and quality of fuels for electric plants 1993

    SciTech Connect

    Not Available

    1994-07-01

    The Cost and Quality of Fuels for Electric Utility Plants (C&Q) presents an annual summary of statistics at the national, Census division, State, electric utility, and plant levels regarding the quantity, quality, and cost of fossil fuels used to produce electricity. The purpose of this publication is to provide energy decision-makers with accurate and timely information that may be used in forming various perspectives on issues regarding electric power.

  16. Cost and quality of fuels for electric utility plants, 1994

    SciTech Connect

    1995-07-14

    This document presents an annual summary of statistics at the national, Census division, State, electric utility, and plant levels regarding the quantity, quality, and cost of fossil fuels used to produce electricity. Purpose of this publication is to provide energy decision-makers with accurate, timely information that may be used in forming various perspectives on issues regarding electric power.

  17. Cost and quality of fuels for electric utility plants, 1992

    SciTech Connect

    Not Available

    1993-08-02

    This publication presents an annual summary of statistics at the national, Census division, State, electric utility, and plant levels regarding the quantity, quality, and cost of fossil fuels used to produce electricity. The purpose of this publication is to provide energy decision-makers with accurate and timely information that may be used in forming various perspectives on issues regarding electric power.

  18. Accurate eye center location through invariant isocentric patterns.

    PubMed

    Valenti, Roberto; Gevers, Theo

    2012-09-01

    Locating the center of the eyes allows for valuable information to be captured and used in a wide range of applications. Accurate eye center location can be determined using commercial eye-gaze trackers, but additional constraints and expensive hardware make these existing solutions unattractive and impossible to use on standard (i.e., visible wavelength), low-resolution images of eyes. Systems based solely on appearance are proposed in the literature, but their accuracy does not allow us to accurately locate and distinguish eye centers movements in these low-resolution settings. Our aim is to bridge this gap by locating the center of the eye within the area of the pupil on low-resolution images taken from a webcam or a similar device. The proposed method makes use of isophote properties to gain invariance to linear lighting changes (contrast and brightness), to achieve in-plane rotational invariance, and to keep low-computational costs. To further gain scale invariance, the approach is applied to a scale space pyramid. In this paper, we extensively test our approach for its robustness to changes in illumination, head pose, scale, occlusion, and eye rotation. We demonstrate that our system can achieve a significant improvement in accuracy over state-of-the-art techniques for eye center location in standard low-resolution imagery. PMID:22813958

  19. Development of standardized air-blown coal gasifier/gas turbine concepts for future electric power systems. Volume 5, Appendix D: Cost support information: Final report

    SciTech Connect

    Sadowski, R.S.; Brown, M.J.; Harriz, J.T.; Ostrowski, E.

    1991-01-01

    The cost estimate provided for the DOE sponsored study of Air Blown Coal Gasification was developed from vendor quotes obtained directly for the equipment needed in the 50 MW, 100 MW, and 200 MW sized plants and from quotes from other jobs that have been referenced to apply to the particular cycle. Quotes were generally obtained for the 100 MW cycle and a scale up/down factor was used to generate the cost estimates for the 200 MW and 50 MW cycles, respectively. Information from GTPro (property of Thermoflow, Inc.) was used to estimate the cost of the 200 MW and 50 MW gas turbine, HRSG, and steam turbines. To available the use of GTPro`s estimated values for this equipment, a comparison was made between the quotes obtained for the 100 MW cycle (ABB GT 11N combustion turbine and a HSRG) against the estimated values by GTPro.

  20. Cost Analysis of Selected Patient Categories within a Dermatology Department Using an ABC Approach

    PubMed Central

    Papadaki, Šárka; Popesko, Boris

    2016-01-01

    Background: Present trends in hospital management are facilitating the utilization of more accurate costing methods, which potentially results in superior cost-related information and improved managerial decision-making. However, the Activity-Based Costing method (ABC), which was designed for cost allocation purposes in the 1980s, is not widely used by healthcare organizations. This study analyzes costs related to selected categories of patients, those suffering from psoriasis, varicose ulcers, eczema and other conditions, within a dermatology department at a Czech regional hospital. Methods: The study was conducted in a hospital department where both inpatient and outpatient care are offered. Firstly, the diseases treated at the department were identified. Further costs were determined for each activity using ABC. The study utilized data from managerial and financial accounting, as well as data obtained through interviews with departmental staff. Using a defined cost-allocation procedure makes it possible to determine the cost of an individual patient with a given disease more accurately than via traditional costing procedures. Results: The cost analysis focused on the differences between the costs related to individual patients within the selected diagnoses, variations between inpatient and outpatient treatments and the costs of activities performed by the dermatology department. Furthermore, comparing the costs identified through this approach and the revenue stemming from the health insurance system is an option. Conclusions: Activity-Based Costing is more accurate and relevant than the traditional costing method. The outputs of ABC provide an abundance of additional information for managers. The benefits of this research lie in its practically-tested outputs, resulting from calculating the costs of hospitalization, which could prove invaluable to persons involved in hospital management and decision-making. The study also defines the managerial implications of

  1. Automatic classification and accurate size measurement of blank mask defects

    NASA Astrophysics Data System (ADS)

    Bhamidipati, Samir; Paninjath, Sankaranarayanan; Pereira, Mark; Buck, Peter

    2015-07-01

    A blank mask and its preparation stages, such as cleaning or resist coating, play an important role in the eventual yield obtained by using it. Blank mask defects' impact analysis directly depends on the amount of available information such as the number of defects observed, their accurate locations and sizes. Mask usability qualification at the start of the preparation process, is crudely based on number of defects. Similarly, defect information such as size is sought to estimate eventual defect printability on the wafer. Tracking of defect characteristics, specifically size and shape, across multiple stages, can further be indicative of process related information such as cleaning or coating process efficiencies. At the first level, inspection machines address the requirement of defect characterization by detecting and reporting relevant defect information. The analysis of this information though is still largely a manual process. With advancing technology nodes and reducing half-pitch sizes, a large number of defects are observed; and the detailed knowledge associated, make manual defect review process an arduous task, in addition to adding sensitivity to human errors. Cases where defect information reported by inspection machine is not sufficient, mask shops rely on other tools. Use of CDSEM tools is one such option. However, these additional steps translate into increased costs. Calibre NxDAT based MDPAutoClassify tool provides an automated software alternative to the manual defect review process. Working on defect images generated by inspection machines, the tool extracts and reports additional information such as defect location, useful for defect avoidance[4][5]; defect size, useful in estimating defect printability; and, defect nature e.g. particle, scratch, resist void, etc., useful for process monitoring. The tool makes use of smart and elaborate post-processing algorithms to achieve this. Their elaborateness is a consequence of the variety and

  2. Cost/scheduling proposal: Groundwater development feasibility study for irrigation in the Chisumbanje area. Export trade information

    SciTech Connect

    Not Available

    1986-02-01

    The document is the third volume of a final report for Phase II of a feasibility study conducted for the Regional Water Authority (RWA) of Zimbabwe. The report documents the second phase of a study to assess the feasibility of developing groundwater for irrigation of the Chisumbanje area. This phase of the study included installation of test boreholes in several locations. The volume encompasses the cost/scheduling proposal which includes the business scope and the cost estimates for Phase I and Phase II.

  3. Human African trypanosomiasis prevention, treatment and control costs: a systematic review.

    PubMed

    Keating, Joseph; Yukich, Joshua O; Sutherland, C Simone; Woods, Geordie; Tediosi, Fabrizio

    2015-10-01

    The control and eventual elimination of human African trypanosomiasis (HAT) requires the expansion of current control and surveillance activities. A systematic review of the published literature on the costs of HAT prevention, treatment, and control, in addition to the economic burden, was conducted. All studies that contained primary or secondary data on costs of prevention, treatment and control were considered, resulting in the inclusion of 42 papers. The geographically focal nature of the disease and a lack of standardization in the cost data limit the usefulness of the available information for making generalizations across diverse settings. More recent information on the costs of treatment and control interventions for HAT is needed to provide accurate information for analyses and planning. The cost information contained herein can be used to inform rational decision making in control and elimination programs, and to assess potential synergies with existing vector-borne disease control programs, but programs would benefit significantly from new cost data collection. PMID:26056739

  4. EPA (Environmental Protection Agency) evaluation of Fuel Maximiser TM under Section 511 of The Motor Vehicle Information And Cost Savings Act. Technical report

    SciTech Connect

    Penninga, T.J.

    1981-11-01

    This document announces the conclusions of the EPA evaluation of the Fuel Maximiser under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The Fuel Maximiser, an automotive fuel economy device, has been evaluated by the Environmental Protection Agency at the request of the U.S. Postal Service. The results of the EPA testing demonstrate that with either road or dynomometer testing procedures, the Fuel Maximiser failed to improve vehicle fuel economy.

  5. EPA evaluation of the Malpassi Filter King device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1983-01-01

    This report announces the conclusions of the EPA evaluation of the 'Malpassi Filter King' device under provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the 'Malpassi Filter King' device was conducted upon receiving an application from the marketer. The device is a gasoline pressure regulator. The 'Malpassi Filter King' device is claimed to save gasoline by improving the fuel economy of carburetor-equipped, automotive engines.

  6. An Investigation of the Perceptions of Low-Income Students of Color Concerning College Costs and Financial Aid Information

    ERIC Educational Resources Information Center

    Waters, Jennifer A.

    2009-01-01

    As college enrollments continue to increase, the disparity between middle-income white students and low-income students of color enrolling in private higher educational institutions continues to widen. Previous research has identified barriers such as access and equity in education, the high cost of education, and limited knowledge regarding…

  7. President's Private Sector Survey on Cost Control. Management Office Selected Issues, Volume VII: Information Gap in the Federal Government.

    ERIC Educational Resources Information Center

    Horan, Richard V.; Kendrick, Keith S.

    Established by Executive Order 12369 on June 30, 1982, the President's Private Sector Survey on Cost Control (PPSSCC) carried out its mandate through an executive committee of 161 high-level private sector executives. The committee set up a management office and 36 task forces with 1,300 members. The task forces were co-chaired by members of the…

  8. Processing of Perceptual Information Is More Robust than Processing of Conceptual Information in Preschool-Age Children: Evidence from Costs of Switching

    ERIC Educational Resources Information Center

    Fisher, Anna V.

    2011-01-01

    Is processing of conceptual information as robust as processing of perceptual information early in development? Existing empirical evidence is insufficient to answer this question. To examine this issue, 3- to 5-year-old children were presented with a flexible categorization task, in which target items (e.g., an open red umbrella) shared category…

  9. Accurate phase-shift velocimetry in rock.

    PubMed

    Shukla, Matsyendra Nath; Vallatos, Antoine; Phoenix, Vernon R; Holmes, William M

    2016-06-01

    Spatially resolved Pulsed Field Gradient (PFG) velocimetry techniques can provide precious information concerning flow through opaque systems, including rocks. This velocimetry data is used to enhance flow models in a wide range of systems, from oil behaviour in reservoir rocks to contaminant transport in aquifers. Phase-shift velocimetry is the fastest way to produce velocity maps but critical issues have been reported when studying flow through rocks and porous media, leading to inaccurate results. Combining PFG measurements for flow through Bentheimer sandstone with simulations, we demonstrate that asymmetries in the molecular displacement distributions within each voxel are the main source of phase-shift velocimetry errors. We show that when flow-related average molecular displacements are negligible compared to self-diffusion ones, symmetric displacement distributions can be obtained while phase measurement noise is minimised. We elaborate a complete method for the production of accurate phase-shift velocimetry maps in rocks and low porosity media and demonstrate its validity for a range of flow rates. This development of accurate phase-shift velocimetry now enables more rapid and accurate velocity analysis, potentially helping to inform both industrial applications and theoretical models. PMID:27111139

  10. Accurate phase-shift velocimetry in rock

    NASA Astrophysics Data System (ADS)

    Shukla, Matsyendra Nath; Vallatos, Antoine; Phoenix, Vernon R.; Holmes, William M.

    2016-06-01

    Spatially resolved Pulsed Field Gradient (PFG) velocimetry techniques can provide precious information concerning flow through opaque systems, including rocks. This velocimetry data is used to enhance flow models in a wide range of systems, from oil behaviour in reservoir rocks to contaminant transport in aquifers. Phase-shift velocimetry is the fastest way to produce velocity maps but critical issues have been reported when studying flow through rocks and porous media, leading to inaccurate results. Combining PFG measurements for flow through Bentheimer sandstone with simulations, we demonstrate that asymmetries in the molecular displacement distributions within each voxel are the main source of phase-shift velocimetry errors. We show that when flow-related average molecular displacements are negligible compared to self-diffusion ones, symmetric displacement distributions can be obtained while phase measurement noise is minimised. We elaborate a complete method for the production of accurate phase-shift velocimetry maps in rocks and low porosity media and demonstrate its validity for a range of flow rates. This development of accurate phase-shift velocimetry now enables more rapid and accurate velocity analysis, potentially helping to inform both industrial applications and theoretical models.

  11. The Costs and Benefits of Information: Data-Based Decisions at the Private Institution. AIR Forum Paper 1978.

    ERIC Educational Resources Information Center

    Jenny, Hans H.

    University information systems are designed to make decisions easier and to provide good information for administrative tasks. Data do not by themselves produce better decisions, and more data can make agreement on issues more complicated. When collegial decisions are made, the precise impact of data and models is uncertain. When there is no…

  12. Protocol for evaluation of the cost-effectiveness of ePrescribing systems and candidate prototype for other related health information technologies

    PubMed Central

    2014-01-01

    Background This protocol concerns the assessment of cost-effectiveness of hospital health information technology (HIT) in four hospitals. Two of these hospitals are acquiring ePrescribing systems incorporating extensive decision support, while the other two will implement systems incorporating more basic clinical algorithms. Implementation of an ePrescribing system will have diffuse effects over myriad clinical processes, so the protocol has to deal with a large amount of information collected at various ‘levels’ across the system. Methods/Design The method we propose is use of Bayesian ideas as a philosophical guide. Assessment of cost-effectiveness requires a number of parameters in order to measure incremental cost utility or benefit – the effectiveness of the intervention in reducing frequency of preventable adverse events; utilities for these adverse events; costs of HIT systems; and cost consequences of adverse events averted. There is no single end-point that adequately and unproblematically captures the effectiveness of the intervention; we therefore plan to observe changes in error rates and adverse events in four error categories (death, permanent disability, moderate disability, minimal effect). For each category we will elicit and pool subjective probability densities from experts for reductions in adverse events, resulting from deployment of the intervention in a hospital with extensive decision support. The experts will have been briefed with quantitative and qualitative data from the study and external data sources prior to elicitation. Following this, there will be a process of deliberative dialogues so that experts can “re-calibrate” their subjective probability estimates. The consolidated densities assembled from the repeat elicitation exercise will then be used to populate a health economic model, along with salient utilities. The credible limits from these densities can define thresholds for sensitivity analyses. Discussion The

  13. Activity-based costing for electric utilities

    SciTech Connect

    Croyle, D.R.; Schapiro, I.A.; Keglevic, P.M. )

    1992-08-01

    This EPRI report is a primer'' on Activity-Based Costing (ABC). ABC is a cost management aproach which can make an important contribution to understanding and controlling the changing costs in the electric utility industry. It is a method for attributing costs to activities, products and services by better understanding the underlying factors which drive those costs. ABC can help utility managers make better decisions through the application of more accurate process and product cost information and a fuller understanding of which activities add value and which do not. Armed with such information, utility managers are better equipped to address many of the strategic and operating decisions which they routinely face. The report introduces the ABC concept and approach to utility managers and offers insights into how ABC can be and is being used to control costs and improve strategic and operating decisions in electric utilities and other industries. The report (1) describes the ABC approach, (2) discusses the value of ABC to elecuic utilities, (3) identifies potential applications of ABC to current utility issues, (4) describes a step-by-step approach to developing and implementing ABC in the utility environment, and (5) presents a survey of more than 30 electric utilities and several detailed case studies of electric utilities and other companies who have adopted and are using ABC.

  14. EPA (Evironmental Protection Agency) evaluation of the Kamei Spoilers under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1983-03-01

    This document announces the conclusions of the EPA evaluation of the Kamei Spoilers under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Kamei Spoilers was conducted upon the application of the manufacturer. The Kamei Spoiler is a plastic spoiler (or air dam) that is about six inches high and extends the width of the vehicle. The spoiler is installed beneath the front bumper to reduce the flow of air under the front of the vehicle. The device is claimed to reduce the aerodynamic drag forces retarding a vehicle and thereby improve fuel economy. EPA fully considered all of the information submitted by the applicant. The evaluation of the Kamei Spoilers was based on that information and EPA's engineering judgement. The overall conclusion is that the Kamei Spoilers have the potential to improve the fuel economy of some motor vehicles.

  15. The Impact of Densification by Means of Informal Shacks in the Backyards of Low-Cost Houses on the Environment and Service Delivery in Cape Town, South Africa

    PubMed Central

    Govender, Thashlin; Barnes, Jo M.; Pieper, Clarissa H.

    2011-01-01

    This paper investigates the state-sponsored low cost housing provided to previously disadvantaged communities in the City of Cape Town. The strain imposed on municipal services by informal densification of unofficial backyard shacks was found to create unintended public health risks. Four subsidized low-cost housing communities were selected within the City of Cape Town in this cross-sectional survey. Data was obtained from 1080 persons with a response rate of 100%. Illegal electrical connections to backyard shacks that are made of flimsy materials posed increased fire risks. A high proportion of main house owners did not pay for water but sold water to backyard dwellers. The design of state-subsidised houses and the unplanned housing in the backyard added enormous pressure on the existing municipal infrastructure and the environment. Municipal water and sewerage systems and solid waste disposal cannot cope with the increased population density and poor sanitation behaviour of the inhabitants of these settlements. The low-cost housing program in South Africa requires improved management and prudent policies to cope with the densification of state-funded low-cost housing settlements. PMID:21695092

  16. The impact of activity based cost accounting on health care capital investment decisions.

    PubMed

    Greene, J K; Metwalli, A

    2001-01-01

    For the future survival of the rural hospitals in the U.S., there is a need to make sound financial decisions. The Activity Based Cost Accounting (ABC) provides more accurate and detailed cost information to make an informed capital investment decision taking into consideration all the costs and revenue reimbursement from third party payors. The paper analyzes, evaluates and compares two scenarios of acquiring capital equipment and attempts to show the importance of utilizing the ABC method in making a sound financial decision as compared to the traditional cost method. PMID:11794757

  17. Social cost impact assessment of pipeline infrastructure projects

    SciTech Connect

    Matthews, John C.; Allouche, Erez N.; Sterling, Raymond L.

    2015-01-15

    A key advantage of trenchless construction methods compared with traditional open-cut methods is their ability to install or rehabilitate underground utility systems with limited disruption to the surrounding built and natural environments. The equivalent monetary values of these disruptions are commonly called social costs. Social costs are often ignored by engineers or project managers during project planning and design phases, partially because they cannot be calculated using standard estimating methods. In recent years some approaches for estimating social costs were presented. Nevertheless, the cost data needed for validation of these estimating methods is lacking. Development of such social cost databases can be accomplished by compiling relevant information reported in various case histories. This paper identifies eight most important social cost categories, presents mathematical methods for calculating them, and summarizes the social cost impacts for two pipeline construction projects. The case histories are analyzed in order to identify trends for the various social cost categories. The effectiveness of the methods used to estimate these values is also discussed. These findings are valuable for pipeline infrastructure engineers making renewal technology selection decisions by providing a more accurate process for the assessment of social costs and impacts. - Highlights: • Identified the eight most important social cost factors for pipeline construction • Presented mathematical methods for calculating those social cost factors • Summarized social cost impacts for two pipeline construction projects • Analyzed those projects to identify trends for the social cost factors.

  18. Activity-Based Costing: A Cost Management Tool.

    ERIC Educational Resources Information Center

    Turk, Frederick J.

    1993-01-01

    In college and university administration, overhead costs are often charged to programs indiscriminately, whereas the support activities that underlie those costs remain unanalyzed. It is time for institutions to decrease ineffective use of resources. Activity-based management attributes costs more accurately and can improve efficiency. (MSE)

  19. Financing and budgetary impact of landslide losses for highways and urban infrastructures in NW Germany - an economic analysis using landslide database information and cost survey data

    NASA Astrophysics Data System (ADS)

    Maurischat, Philipp; Klose, Martin

    2014-05-01

    Recent studies show that landslides cause even in low mountain areas of Central and Western Europe millions of dollars in annual losses (Klose et al., 2012; Vranken et al., 2013). The objective of this study has therefore been to model landslide disaster financing and to assess budgetary impacts of landslide losses for highways and urban infrastructures in the Lower Saxon Uplands, NW Germany. The present contribution includes two case studies on the financial burden of landslides for public budgets using the examples of the Lower Saxony Department of Transportation and the city of Hann. Münden. The basis of this research is a regional subset of a landslide database for the Federal Republic of Germany. Using a toolset for landslide cost modeling based on landslide databases (Klose et al., 2013), the direct costs of more than 30 landslide damage events to highways in a local case study area were determined. The annual average landslide maintenance, repair, and mitigation costs for highways in this case study area are estimated at 0.76 million between 1980 and 2010. Alternatively, a cost survey based on expert interviews has been conducted to collect landslide loss data for urban infrastructures. This cost survey for the city of Hann. Münden shows annual landslide losses of up to 3.4 million during the previous 10 years. Further expert interviews at city and highway agency level were focused on identifying procedure, resources, and limits of financing landslide damage costs. The information on landslide disaster financing and cost survey data on annual maintenance and construction budgets for highways, city sewer lines, and urban roads were used to evaluate the fiscal significance of estimated landslide losses. The results of this economic impact assessment prove variable financial burdens of analyzed public budgets. Thus, in costly years with landslide losses of more than 7 million, the Lower Saxony Department of Transportation is required to shift up to 19% of its

  20. Activity-Based Costing in the After Press Services Industry

    NASA Astrophysics Data System (ADS)

    Shevasuthisilp, Suntichai; Punsathitwong, Kosum

    2009-10-01

    This research was conducted to apply activity-based costing (ABC) in an after press service company in Chiang Mai province, Thailand. The company produces all of its products by one-stop service (such as coating, stitching, binding, die cutting, and gluing). All products are made to order, and have different sizes and patterns. A strategy of low price is used to compete in the marketplace. After cost analysis, the study found that the company has high overhead (36.5% of total cost). The company's problem is its use of traditional cost accounting, which has low accuracy in assigning overhead costs. If management uses this information when pricing customer orders, losses may occur because real production costs may be higher than the selling price. Therefore, the application of ABC in cost analysis can help executives receive accurate cost information; establish a sound pricing strategy; and improve the manufacturing process by determining work activities which have excessively high production costs. According to this research, 6 out of 56 items had a production cost higher than the selling price, leading to losses of 123,923 baht per year. Methods used to solve this problem were: reducing production costs; establishing suitable prices; and creating a sales promotion with lower prices for customers whose orders include processes involving unused capacity. These actions will increase overall sales of the company, and allow more efficient use of its machinery.

  1. New law requires 'medically accurate' lesson plans.

    PubMed

    1999-09-17

    The California Legislature has passed a bill requiring all textbooks and materials used to teach about AIDS be medically accurate and objective. Statements made within the curriculum must be supported by research conducted in compliance with scientific methods, and published in peer-reviewed journals. Some of the current lesson plans were found to contain scientifically unsupported and biased information. In addition, the bill requires material to be "free of racial, ethnic, or gender biases." The legislation is supported by a wide range of interests, but opposed by the California Right to Life Education Fund, because they believe it discredits abstinence-only material. PMID:11366835

  2. Practical aspects of spatially high accurate methods

    NASA Technical Reports Server (NTRS)

    Godfrey, Andrew G.; Mitchell, Curtis R.; Walters, Robert W.

    1992-01-01

    The computational qualities of high order spatially accurate methods for the finite volume solution of the Euler equations are presented. Two dimensional essentially non-oscillatory (ENO), k-exact, and 'dimension by dimension' ENO reconstruction operators are discussed and compared in terms of reconstruction and solution accuracy, computational cost and oscillatory behavior in supersonic flows with shocks. Inherent steady state convergence difficulties are demonstrated for adaptive stencil algorithms. An exact solution to the heat equation is used to determine reconstruction error, and the computational intensity is reflected in operation counts. Standard MUSCL differencing is included for comparison. Numerical experiments presented include the Ringleb flow for numerical accuracy and a shock reflection problem. A vortex-shock interaction demonstrates the ability of the ENO scheme to excel in simulating unsteady high-frequency flow physics.

  3. Cost estimation model for advanced planetary programs, fourth edition

    NASA Technical Reports Server (NTRS)

    Spadoni, D. J.

    1983-01-01

    The development of the planetary program cost model is discussed. The Model was updated to incorporate cost data from the most recent US planetary flight projects and extensively revised to more accurately capture the information in the historical cost data base. This data base is comprised of the historical cost data for 13 unmanned lunar and planetary flight programs. The revision was made with a two fold objective: to increase the flexibility of the model in its ability to deal with the broad scope of scenarios under consideration for future missions, and to maintain and possibly improve upon the confidence in the model's capabilities with an expected accuracy of 20%. The Model development included a labor/cost proxy analysis, selection of the functional forms of the estimating relationships, and test statistics. An analysis of the Model is discussed and two sample applications of the cost model are presented.

  4. Accurate calculation of the absolute free energy of binding for drug molecules† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02678d Click here for additional data file.

    PubMed Central

    Aldeghi, Matteo; Heifetz, Alexander; Bodkin, Michael J.; Knapp, Stefan

    2016-01-01

    Accurate prediction of binding affinities has been a central goal of computational chemistry for decades, yet remains elusive. Despite good progress, the required accuracy for use in a drug-discovery context has not been consistently achieved for drug-like molecules. Here, we perform absolute free energy calculations based on a thermodynamic cycle for a set of diverse inhibitors binding to bromodomain-containing protein 4 (BRD4) and demonstrate that a mean absolute error of 0.6 kcal mol–1 can be achieved. We also show a similar level of accuracy (1.0 kcal mol–1) can be achieved in pseudo prospective approach. Bromodomains are epigenetic mark readers that recognize acetylation motifs and regulate gene transcription, and are currently being investigated as therapeutic targets for cancer and inflammation. The unprecedented accuracy offers the exciting prospect that the binding free energy of drug-like compounds can be predicted for pharmacologically relevant targets. PMID:26798447

  5. EPA (Environmental Protection Agency) evaluation of the Mesco Moisture Extraction System under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1983-07-01

    This document announces the conclusions of the EPA evaluation of the Mesco Moisture Extraction System device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Mesco Moisture Extraction System was conducted upon the application of the manufacturer. The device is an exhaust gas recirculation (EGR) system. The device supplements the EGR system of a vehicle by adding cooled and filtered exhaust gas to the carburetor. The ignition timing is also advanced. This combination of advanced timing and supplemental EGR is claimed to result in a longer cleaner burn that improves engine performance and reduces emissions.

  6. EPA (Environmental Protection Agency) evaluation of the gyroscopic wheel cover device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1983-06-01

    This report announces the conclusions of the Environmental Protection Agency (EPA) evaluation of the Gyroscopic Wheel Cover under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Gyroscopic Wheel Cover device was conducted upon the application of Simmer Wheels, Incorporated. The device is a mechanical assembly which replaces each of the standard wheel covers on a vehicle. The device is claimed to improve fuel economy, handling and braking characteristics, and the life of the brakes and tires.

  7. EPA (Environmental Protection Agency) evaluation of the Jacona Fuel System under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1982-08-01

    This document announces the conclusions of the EPA evaluation of the Jacona Fuel System under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Jacona Fuel System was conducted upon receiving an application from the inventor/marketer of the device. The Jacona Fuel System is an electrically-powered in-line fuel heater that is installed between the fuel pump and the fuel induction system. This device is claimed to improve fuel economy of a vehicle without adversely affecting emissions.

  8. EPA (Environmental Protection Agency) evaluation of the P. S. C. U. 01 device under section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Syria, S.L.

    1983-08-01

    This document announces the conclusions of the EPA evaluation of the 'P.S.C.U. 01' device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the P.S.C.U. 01 was conducted upon the application of Dutch Pacific, Incorporated. The device is comprised of several mechanical and electrical components and is intended to generate steam and deliver it to the combustion chamber via an inline catalyst. The device is claimed to improve fuel economy and to reduce exhaust emissions. The P.S.C.U. 01 is classified by EPA as a Vapor bleed device.

  9. Use of information systems as management tools in health care

    NASA Astrophysics Data System (ADS)

    Davila, Fidel

    1995-10-01

    Information systems that can be used as effective management tools in healthcare do not exist. This is because current information systems do not accurately reflect reality and because they do not provide information to important end-users, i.e., clinicians. To reflect reality, healthcare information systems must assess total health care costs. These not only include the direct economic costs (dollars paid) but also the indirect economic costs (dollars lost, spent, or saved) from having a person ill. These systems must also accurately assess the adjusted, qualitative costs of human life and human pain and suffering resulting from the illness and healthcare provided. Once information systems reflect reality, they can be used to manage healthcare by profiling utilization, projecting need, modeling programs, assessing quality of care and establishing guidelines.

  10. The cost of doing a cost estimate

    NASA Technical Reports Server (NTRS)

    Remer, Donald S.; Buchanan, Harry R.

    1993-01-01

    A model for estimating the cost required to do a cost estimate for Deep Space Network (DSN) projects that range from $0.1 to $100 million is presented. The cost of the cost estimate in thousands of dollars, C(sub E), is found to be approximately given by C(sub E) = K(/C(sub p)/(sup 0.35)) where C(sub p) is the cost of the project being estimated in millions of dollars and K is a constant depending on the accuracy of the estimate. For an order-of-magnitude estimate, K = 24; for a budget estimate, K = 60; and for a definitive estimate, K = 115. That is, for a specific project, the cost of doing a budget estimate is about 2.5 times as much as that for an order-of-magnitude estimate, and a definitive estimate costs about twice as much as a budget estimate. Use of this model should help provide the level of resources required for doing cost estimates and, as a result, provide insights towards more accurate estimates with less potential for cost overruns.

  11. Cost of dengue outbreaks: literature review and country case studies

    PubMed Central

    2013-01-01

    different cost components (vector control; surveillance; information, education and communication; direct medical and indirect costs), as percentage of total costs, differed across the respective countries. Resources used for dengue disease control and treatment were country specific. Conclusions The evidence so far collected further confirms the methodological challenges in this field: 1) to define technically dengue outbreaks (what do we measure?) and 2) to measure accurately the costs in prospective field studies (how do we measure?). Currently, consensus on the technical definition of an outbreak is sought through the International Research Consortium on Dengue Risk Assessment, Management and Surveillance (IDAMS). Best practice guidelines should be further developed, also to improve the quality and comparability of cost study findings. Modelling the costs of dengue outbreaks and validating these models through field studies should guide further research. PMID:24195519

  12. COST OF MTBE REMEDIATION

    EPA Science Inventory

    Widespread contamination of methyl tert-butyl ether (MTBE) in ground water has raised concerns about the increased cost of remediation of MTBE releases compared to BTEX-only sites. To evaluate these cost, cost information for 311 sites was furnished by U.S. EPA Office of Undergr...

  13. EPA evaluation of the gas saving and emission control improvement device under Section 511 of the Motor Vehicle Information and Cost Savings Act

    SciTech Connect

    Barth, E.A.

    1983-01-01

    This document announces the conclusions of the EPA evaluation of the Gas Saving and Emission Control Improvement device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the 'Gas Saving and Emission Control Improvement' device was conducted upon receiving an application for evaluation by the manufacturer. The device is a 3/4 inch thick carburetor adapter plate that is installed between the carburetor and intake manifold. The device is claimed to reduce emissions, improve fuel economy, clean the engine and make it virtually maintenance free, and improve engine power. The information supplied by the applicant was insufficient to adequately substantiate either the emissions or fuel economy benefits claimed for the device.

  14. Role of information systems in controlling costs: the electronic medical record (EMR) and the high-performance computing and communications (HPCC) efforts

    NASA Astrophysics Data System (ADS)

    Kun, Luis G.

    1994-12-01

    On October 18, 1991, the IEEE-USA produced an entity statement which endorsed the vital importance of the High Performance Computer and Communications Act of 1991 (HPCC) and called for the rapid implementation of all its elements. Efforts are now underway to develop a Computer Based Patient Record (CBPR), the National Information Infrastructure (NII) as part of the HPCC, and the so-called `Patient Card'. Multiple legislative initiatives which address these and related information technology issues are pending in Congress. Clearly, a national information system will greatly affect the way health care delivery is provided to the United States public. Timely and reliable information represents a critical element in any initiative to reform the health care system as well as to protect and improve the health of every person. Appropriately used, information technologies offer a vital means of improving the quality of patient care, increasing access to universal care and lowering overall costs within a national health care program. Health care reform legislation should reflect increased budgetary support and a legal mandate for the creation of a national health care information system by: (1) constructing a National Information Infrastructure; (2) building a Computer Based Patient Record System; (3) bringing the collective resources of our National Laboratories to bear in developing and implementing the NII and CBPR, as well as a security system with which to safeguard the privacy rights of patients and the physician-patient privilege; and (4) utilizing Government (e.g. DOD, DOE) capabilities (technology and human resources) to maximize resource utilization, create new jobs and accelerate technology transfer to address health care issues.

  15. Costing of consumables: use in an intensive care unit.

    PubMed

    Mann, S A

    1999-08-01

    In 1991, the Intensive Care Unit (ICU) at Middlemore Hospital manually costed the treatment and care of asthmatic patients. This was long-winded and labour-intensive, but provided hard data to support anecdotal beliefs that intensive care patients are more expensive than was currently believed or accepted. It is a known problem that funder and provider organizations see a huge disparity on the funding issue. With additional accurate information on the actual cost of individual patients, which can be grouped into disease categories, funding applications can be backed with accurate, up-to-date quantitative data. After a long preparation time, we are now costing individual patient stays in the ICU. Each individual resource was established, costed and entered into an MS ACCESS computerized database. Schedules have been prepared for updating prices, as these change. The final report available gives a detailed list of resource use within certain categories. Some items proved to be impractical to cost on an individual patient basis, and these have been grouped together, costed, and divided by the number of patient days for the last year, and assigned to each individual patient as an hourly unit cost. Believed to be a world-first, this information now forms the basis for variance reporting and pricing. PMID:10786509

  16. Predict amine solution properties accurately

    SciTech Connect

    Cheng, S.; Meisen, A.; Chakma, A.

    1996-02-01

    Improved process design begins with using accurate physical property data. Especially in the preliminary design stage, physical property data such as density viscosity, thermal conductivity and specific heat can affect the overall performance of absorbers, heat exchangers, reboilers and pump. These properties can also influence temperature profiles in heat transfer equipment and thus control or affect the rate of amine breakdown. Aqueous-amine solution physical property data are available in graphical form. However, it is not convenient to use with computer-based calculations. Developed equations allow improved correlations of derived physical property estimates with published data. Expressions are given which can be used to estimate physical properties of methyldiethanolamine (MDEA), monoethanolamine (MEA) and diglycolamine (DGA) solutions.

  17. Accurate thickness measurement of graphene

    NASA Astrophysics Data System (ADS)

    Shearer, Cameron J.; Slattery, Ashley D.; Stapleton, Andrew J.; Shapter, Joseph G.; Gibson, Christopher T.

    2016-03-01

    Graphene has emerged as a material with a vast variety of applications. The electronic, optical and mechanical properties of graphene are strongly influenced by the number of layers present in a sample. As a result, the dimensional characterization of graphene films is crucial, especially with the continued development of new synthesis methods and applications. A number of techniques exist to determine the thickness of graphene films including optical contrast, Raman scattering and scanning probe microscopy techniques. Atomic force microscopy (AFM), in particular, is used extensively since it provides three-dimensional images that enable the measurement of the lateral dimensions of graphene films as well as the thickness, and by extension the number of layers present. However, in the literature AFM has proven to be inaccurate with a wide range of measured values for single layer graphene thickness reported (between 0.4 and 1.7 nm). This discrepancy has been attributed to tip-surface interactions, image feedback settings and surface chemistry. In this work, we use standard and carbon nanotube modified AFM probes and a relatively new AFM imaging mode known as PeakForce tapping mode to establish a protocol that will allow users to accurately determine the thickness of graphene films. In particular, the error in measuring the first layer is reduced from 0.1-1.3 nm to 0.1-0.3 nm. Furthermore, in the process we establish that the graphene-substrate adsorbate layer and imaging force, in particular the pressure the tip exerts on the surface, are crucial components in the accurate measurement of graphene using AFM. These findings can be applied to other 2D materials.

  18. Costs of groundwater contamination

    SciTech Connect

    O'Neil, W.B.; Raucher, R.S. )

    1990-01-01

    Two factors determine the cost of groundwater contamination: (1) the ways in which water was being used or was expected to be used in the future and (2) the physical characteristics of the setting that constrain the responses available to regain lost uses or to prevent related damages to human health and the environment. Most contamination incidents can be managed at a low enough cost that uses will not be foreclosed. It is important to take into account the following when considering costs: (1) natural cleansing through recharge and dilution can take many years; (2) it is difficult and costly to identify the exact area and expected path of a contamination plume; and (3) treatment or replacement of contaminated water often may represent the cost-effective strategy for managing the event. The costs of contamination include adverse health effects, containment and remediation, treatment and replacement costs. In comparing the costs and benefits of prevention programs with those of remediation, replacement or treatment, it is essential to adjust the cost/benefit numbers by the probability of their actual occurrence. Better forecasts of water demand are needed to predict more accurately the scarcity of new supply and the associated cost of replacement. This research should include estimates of the price elasticity of water demand and the possible effect on demand of more rational cost-based pricing structures. Research and development of techniques for in situ remediation should be encouraged.

  19. Accurate ab Initio Spin Densities

    PubMed Central

    2012-01-01

    We present an approach for the calculation of spin density distributions for molecules that require very large active spaces for a qualitatively correct description of their electronic structure. Our approach is based on the density-matrix renormalization group (DMRG) algorithm to calculate the spin density matrix elements as a basic quantity for the spatially resolved spin density distribution. The spin density matrix elements are directly determined from the second-quantized elementary operators optimized by the DMRG algorithm. As an analytic convergence criterion for the spin density distribution, we employ our recently developed sampling-reconstruction scheme [J. Chem. Phys.2011, 134, 224101] to build an accurate complete-active-space configuration-interaction (CASCI) wave function from the optimized matrix product states. The spin density matrix elements can then also be determined as an expectation value employing the reconstructed wave function expansion. Furthermore, the explicit reconstruction of a CASCI-type wave function provides insight into chemically interesting features of the molecule under study such as the distribution of α and β electrons in terms of Slater determinants, CI coefficients, and natural orbitals. The methodology is applied to an iron nitrosyl complex which we have identified as a challenging system for standard approaches [J. Chem. Theory Comput.2011, 7, 2740]. PMID:22707921

  20. Cost Recovery Through Depreciation.

    ERIC Educational Resources Information Center

    Forrester, Robert T.; Wesolowski, Leonard V.

    1983-01-01

    The approach of adopting depreciation rather than use allowance in order to recover more accurately the cost of college buildings and equipment used on federal projects is considered. It is suggested that depreciation will offer most colleges and universities a higher annual recovery rate, and an opportunity for better facilities planning. For…

  1. EPA (Environmental Protection Agency) evaluation of the optimizer device under Section 511 of the Motor Vehicle Information and Cost Savings Act

    SciTech Connect

    Barth, E.A.

    1983-05-01

    This report announces the conclusions of the EPA evaluation of the Optimizer device under the provisions of section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Optimizer was conducted upon the application of the manufacturer. The basic device is a combustion catalyst consisting of an electric fuel heater containing a bed of platinum deposited on an inert substrate. The remainder of the system includes a heater relay, a condenser to cool the fuel to operating temperature, and the associated plumbing. According to the applicant, the device introduces a very small amount of platinum into the fuel. This enhances the combustion process and allows ignition timing to be advanced. The device, coupled with the ignition timing adjustments, is claimed to improve fuel economy, increase performance, and reduce engine maintenance while keeping emissions low. EPA fully considered all of the information submitted by the applicant. The evaluation of the Optimizer device was based on that information and EPA's engineering judgement. The overall conclusion is that, for most vehicles, the device and the prescribed ignition timing adjustments of the engine will cause a small improvement in fuel economy and a large increase in NOx (oxides of nitrogen) emissions.

  2. EPA (Environmental Protection Agency) evaluation of the P. A. S. S. kit device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1982-09-01

    This document announces the conclusions of the EPA evaluation of the P.A.S.S. Kit device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the P.A.S.S. Kit device was conducted upon receiving an application for evaluation by the marketer. The P.A.S.S. Kit device is an intake manifold vacuum switch that is designed to disengage the air conditioning compressor during periods of high power demand. The device is claimed to eliminate the load of air conditioning compressor when accelerating and thereby improve fuel economy and performance. EPA fully considered all of the information submitted by the applicant. The evaluation of the P.A.S.S. Kit device was based on that information and the results of the EPA confirmatory testing of a similar device. The overall conclusion is that P.A.S.S. Kit should recover part of the emissions and fuel economy penalty incurred by using the air conditioner of some vehicles.

  3. Accurate wavelength calibration method for flat-field grating spectrometers.

    PubMed

    Du, Xuewei; Li, Chaoyang; Xu, Zhe; Wang, Qiuping

    2011-09-01

    A portable spectrometer prototype is built to study wavelength calibration for flat-field grating spectrometers. An accurate calibration method called parameter fitting is presented. Both optical and structural parameters of the spectrometer are included in the wavelength calibration model, which accurately describes the relationship between wavelength and pixel position. Along with higher calibration accuracy, the proposed calibration method can provide information about errors in the installation of the optical components, which will be helpful for spectrometer alignment. PMID:21929865

  4. Price-transparency and cost accounting: challenges for health care organizations in the consumer-driven era.

    PubMed

    Hilsenrath, Peter; Eakin, Cynthia; Fischer, Katrina

    2015-01-01

    Health care reform is directed toward improving access and quality while containing costs. An essential part of this is improvement of pricing models to more accurately reflect the costs of providing care. Transparent prices that reflect costs are necessary to signal information to consumers and producers. This information is central in a consumer-driven marketplace. The rapid increase in high deductible insurance and other forms of cost sharing incentivizes the search for price information. The organizational ability to measure costs across a cycle of care is an integral component of creating value, and will play a greater role as reimbursements transition to episode-based care, value-based purchasing, and accountable care organization models. This article discusses use of activity-based costing (ABC) to better measure the cost of health care. It describes examples of ABC in health care organizations and discusses impediments to adoption in the United States including cultural and institutional barriers. PMID:25862425

  5. Environmental Protection Agency (EPA) evaluation of the Super-Mag Fuel Extender under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Ashby, H.A.

    1982-01-01

    This document announces the conclusions of the EPA evaluation of the 'Super-Mag Fuel Extender' device under provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. On December 10, 1980, the EPA received a written request from the Metropolitan Denver District Attorney's Office of Consumer Fraud and Economic Crime to test at least one 'cow magnet' type of fuel economy device. Following a survey of devices being marketed, the Metropolitan Denver District Attorney's Office selected the 'Super-Mag' device as typical of its category and on April 13, 1981 provided EPA with units for testing. The EPA evaluation of the device using three vehicles showed neither fuel economy nor exhaust emissions were affected by the installation of the 'Super-Mag' device. In addition, any differences between baseline test results and results from tests with the device installed were within the range of normal test variability.

  6. EPA evaluation of the VCD supplemental gaseous fuel delivery system under section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1983-09-01

    This report announces the conclusions of the Environmental Protection Agency (EPA) evaluation of the 'VCD Supplemental Gaseous Fuel Delivery System' under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the 'VCD Supplemental Gaseous Fuel Delivery System' was conducted on the application of the manufacturer. The device is designed to operate the engine of a vehicle on a mixture of gasoline and propane. The device consists of a gaseous fuel metering and control unit, a modified carburetor and associated electrical and plumbing components. It functions by replacing some of the gasoline with propane under certain operating conditions. The device causes the engine to idle on propane, cruise on gasoline, and accelerate on a mixture of the two fuels. This is claimed to be more fuel efficient. This combination of improvements in fuel efficency and fuel substitution is claimed to save both fuel and money.

  7. EPA (Environmental Protection Agency) evaluation of the Dynamix device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1982-08-01

    This document announces the conclusion the EPA evaluation of the Dynamix device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the Dynamix was conducted upon receiving a request from the inventor of the device. The Dynamix device is claimed to permit an unmodified conventional engine to operate efficiently on a blend of gasoline and hydrous ethyl alcohol. The ratio of gasoline to alcohol is selected by the operator. The device consists of an alcohol fuel storage and handling system, an alcohol/gasoline fuel proportioning valve, and an alcohol/heated air induction system. The Dynamix meters vaporized alcohol and hot air directly into the intake manifold of a vehicle. The flow of gasoline is controlled by the flow of alcohol.

  8. Costing the satellite power system

    NASA Technical Reports Server (NTRS)

    Hazelrigg, G. A., Jr.

    1978-01-01

    The paper presents a methodology for satellite power system costing, places approximate limits on the accuracy possible in cost estimates made at this time, and outlines the use of probabilistic cost information in support of the decision-making process. Reasons for using probabilistic costing or risk analysis procedures instead of standard deterministic costing procedures are considered. Components of cost, costing estimating relationships, grass roots costing, and risk analysis are discussed. Risk analysis using a Monte Carlo simulation model is used to estimate future costs.

  9. Accurate, meshless methods for magnetohydrodynamics

    NASA Astrophysics Data System (ADS)

    Hopkins, Philip F.; Raives, Matthias J.

    2016-01-01

    Recently, we explored new meshless finite-volume Lagrangian methods for hydrodynamics: the `meshless finite mass' (MFM) and `meshless finite volume' (MFV) methods; these capture advantages of both smoothed particle hydrodynamics (SPH) and adaptive mesh refinement (AMR) schemes. We extend these to include ideal magnetohydrodynamics (MHD). The MHD equations are second-order consistent and conservative. We augment these with a divergence-cleaning scheme, which maintains nabla \\cdot B≈ 0. We implement these in the code GIZMO, together with state-of-the-art SPH MHD. We consider a large test suite, and show that on all problems the new methods are competitive with AMR using constrained transport (CT) to ensure nabla \\cdot B=0. They correctly capture the growth/structure of the magnetorotational instability, MHD turbulence, and launching of magnetic jets, in some cases converging more rapidly than state-of-the-art AMR. Compared to SPH, the MFM/MFV methods exhibit convergence at fixed neighbour number, sharp shock-capturing, and dramatically reduced noise, divergence errors, and diffusion. Still, `modern' SPH can handle most test problems, at the cost of larger kernels and `by hand' adjustment of artificial diffusion. Compared to non-moving meshes, the new methods exhibit enhanced `grid noise' but reduced advection errors and diffusion, easily include self-gravity, and feature velocity-independent errors and superior angular momentum conservation. They converge more slowly on some problems (smooth, slow-moving flows), but more rapidly on others (involving advection/rotation). In all cases, we show divergence control beyond the Powell 8-wave approach is necessary, or all methods can converge to unphysical answers even at high resolution.

  10. Accurate Inventories Of Irrigated Land

    NASA Technical Reports Server (NTRS)

    Wall, S.; Thomas, R.; Brown, C.

    1992-01-01

    System for taking land-use inventories overcomes two problems in estimating extent of irrigated land: only small portion of large state surveyed in given year, and aerial photographs made on 1 day out of year do not provide adequate picture of areas growing more than one crop per year. Developed for state of California as guide to controlling, protecting, conserving, and distributing water within state. Adapted to any large area in which large amounts of irrigation water needed for agriculture. Combination of satellite images, aerial photography, and ground surveys yields data for computer analysis. Analyst also consults agricultural statistics, current farm reports, weather reports, and maps. These information sources aid in interpreting patterns, colors, textures, and shapes on Landsat-images.

  11. EPA (Environmental Protection Agency) evaluation of the Polarion-X device under Section 511 of the Motor Vehicle Information and Cost Savings Act

    SciTech Connect

    Barth, E.A.

    1982-08-01

    This document announces the conclusions of the EPA evaluation of the POLARION-X device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The evaluation of the POLARION-X device was conducted upon receiving an application from the marketer of the device. The POLARION-X is installed in the fuel line between the pump and the carburetor. It incorporates two permanent magnets which subject the fuel to a magnetic field. This device is claimed to reduce emissions, to improve fuel economy and performance, to provide more complete combustion, to eliminate engine carbon buildup and dieseling, and to reduce the octane requirements of the engine. The Environmental Protection Agency (EPA) fully considered all of the information submitted by the applicant. The overall conclusion was that for the POLARION-X there is no reason to expect that the device will improve either the emissions or fuel economy of a typical motor vehicle in proper operating conditions.

  12. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  13. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  14. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  15. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  16. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  17. Wind Integration Cost and Cost-Causation: Preprint

    SciTech Connect

    Milligan, M.; Kirby, B.; Holttinen, H.; Kiviluoma, J.; Estanqueiro, A.; Martin-Martinez, S.; Gomez-Lazaro, E.; Peneda, I.; Smith, C.

    2013-10-01

    The question of wind integration cost has received much attention in the past several years. The methodological challenges to calculating integration costs are discussed in this paper. There are other sources of integration cost unrelated to wind energy. A performance-based approach would be technology neutral, and would provide price signals for all technology types. However, it is difficult to correctly formulate such an approach. Determining what is and is not an integration cost is challenging. Another problem is the allocation of system costs to one source. Because of significant nonlinearities, this can prove to be impossible to determine in an accurate and objective way.

  18. Towards accurate and automatic morphing

    NASA Astrophysics Data System (ADS)

    Wang, Zhe; Sharkey, Paul M.

    2005-10-01

    Image morphing has proved to be a powerful tool for generating compelling and pleasing visual effects and has been widely used in entertainment industry. However, traditional image morphing methods suffer from a number of drawbacks: feature specification between images is tedious and the reliance on 2D information ignores the possible advantages to be gained from 3D knowledge. In this paper, we utilize recent advantages of computer vision technologies to diminish these drawbacks. By analyzing multi view geometry theories, we propose a processing pipeline based on three reference images. We first seek a few seed correspondences using robust methods and then recover multi view geometries using the seeds, through bundle adjustment. Guided by the recovered two and three view geometries, a novel line matching algorithm across three views is then deduced, through edge growth, line fitting and two and three view geometry constraints. Corresponding lines on a novel image is then obtained by an image transfer method and finally matched lines are fed into the traditional morphing methods and novel images are generated. Novel images generated by this pipeline have advantages over traditional morphing methods: they have an inherent 3D foundation and are therefore physically close to real scenes; not only images located between the baseline connecting two reference image centers, but also extrapolated images away from the baseline are possible; and the whole processing can be either wholly automatic, or at least the tedious task of feature specification in traditional morphing methods can be greatly relieved.

  19. A method for producing large, accurate, economical female molds

    SciTech Connect

    Guenter, A.; Guenter, B.

    1996-11-01

    A process in which lightweight, highly accurate, economical molds can be produced for prototype and low production runs of large parts for use in composites molding has been developed. This has been achieved by developing existing milling technology, using new materials and innovative material applications to CNC mill large female molds directly. Any step that can be eliminated in the mold building process translates into savings in tooling costs through reduced labor and material requirements.

  20. Educational Costs.

    ERIC Educational Resources Information Center

    Arnold, Robert

    Problems in educational cost accounting and a new cost accounting approach are described in this paper. The limitations of the individualized cost (student units) approach and the comparative cost approach (in the form of fund-function-object) are illustrated. A new strategy, an activity-based system of accounting, is advocated. Borrowed from…

  1. The importance of accurate atmospheric modeling

    NASA Astrophysics Data System (ADS)

    Payne, Dylan; Schroeder, John; Liang, Pang

    2014-11-01

    This paper will focus on the effect of atmospheric conditions on EO sensor performance using computer models. We have shown the importance of accurately modeling atmospheric effects for predicting the performance of an EO sensor. A simple example will demonstrated how real conditions for several sites in China will significantly impact on image correction, hyperspectral imaging, and remote sensing. The current state-of-the-art model for computing atmospheric transmission and radiance is, MODTRAN® 5, developed by the US Air Force Research Laboratory and Spectral Science, Inc. Research by the US Air Force, Navy and Army resulted in the public release of LOWTRAN 2 in the early 1970's. Subsequent releases of LOWTRAN and MODTRAN® have continued until the present. Please verify that (1) all pages are present, (2) all figures are correct, (3) all fonts and special characters are correct, and (4) all text and figures fit within the red margin lines shown on this review document. Complete formatting information is available at http://SPIE.org/manuscripts Return to the Manage Active Submissions page at http://spie.org/submissions/tasks.aspx and approve or disapprove this submission. Your manuscript will not be published without this approval. Please contact author_help@spie.org with any questions or concerns. The paper will demonstrate the importance of using validated models and local measured meteorological, atmospheric and aerosol conditions to accurately simulate the atmospheric transmission and radiance. Frequently default conditions are used which can produce errors of as much as 75% in these values. This can have significant impact on remote sensing applications.

  2. Use of molecular and milk production information for the cost-effective diagnosis of bovine viral diarrhoea infection in New Zealand dairy cattle.

    PubMed

    Hill, F I; Reichel, M P; Tisdall, D J

    2010-04-21

    An increase in veterinary and farmer interest in bovine viral diarrhoea (BVD) in New Zealand over recent years led to requests for cost-effective identification of BVD virus (BVDV) infected herds and individuals. This study was undertaken to determine if the use of real-time reverse transcriptase polymerase chain reaction (RT-PCR) technology and dairy cow production data could identify persistently infected (PI) animals in milking herds. Milk samples were collected from the vats of dairy herds and tested for the presence of BVDV by RT-PCR till four herds were found containing PI animals. Individual serum samples were then collected from every cow in the herd and tested by both RT-PCR and antigen capture enzyme-linked immunosorbent assays (ACE) to identify the PI animals. Individual animal testing found 1/223, 1/130, 2/800 and 1/275 PI's respectively in the four herds. Based on these results a maximum pool size of 400 cows contributing to the bulk tank milk was selected. After removal of the PI from the herds, further bulk milk samples were shown to be BVDV negative by RT-PCR. All the PI animals identified by this method were found in the lowest producing 10-20% of herd. This approach of targeted testing of dairy herds using PCR technology, in conjunction with animal production information, markedly reduced the cost of diagnostic testing for BVDV in dairy herds in New Zealand. Questionnaire follow-up on 81 BVDV-positive herds (15% of those tested) indicated the stratification approach identified milking PIs successfully over 90% of the time and reduced the number of individual tests to 12% of the milking herd. PMID:19837521

  3. Accurate Mass Measurements in Proteomics

    SciTech Connect

    Liu, Tao; Belov, Mikhail E.; Jaitly, Navdeep; Qian, Weijun; Smith, Richard D.

    2007-08-01

    To understand different aspects of life at the molecular level, one would think that ideally all components of specific processes should be individually isolated and studied in details. Reductionist approaches, i.e., studying one biological event at a one-gene or one-protein-at-a-time basis, indeed have made significant contributions to our understanding of many basic facts of biology. However, these individual “building blocks” can not be visualized as a comprehensive “model” of the life of cells, tissues, and organisms, without using more integrative approaches.1,2 For example, the emerging field of “systems biology” aims to quantify all of the components of a biological system to assess their interactions and to integrate diverse types of information obtainable from this system into models that could explain and predict behaviors.3-6 Recent breakthroughs in genomics, proteomics, and bioinformatics are making this daunting task a reality.7-14 Proteomics, the systematic study of the entire complement of proteins expressed by an organism, tissue, or cell under a specific set of conditions at a specific time (i.e., the proteome), has become an essential enabling component of systems biology. While the genome of an organism may be considered static over short timescales, the expression of that genome as the actual gene products (i.e., mRNAs and proteins) is a dynamic event that is constantly changing due to the influence of environmental and physiological conditions. Exclusive monitoring of the transcriptomes can be carried out using high-throughput cDNA microarray analysis,15-17 however the measured mRNA levels do not necessarily correlate strongly with the corresponding abundances of proteins,18-20 The actual amount of functional proteins can be altered significantly and become independent of mRNA levels as a result of post-translational modifications (PTMs),21 alternative splicing,22,23 and protein turnover.24,25 Moreover, the functions of expressed

  4. Leasing strategies reduce the cost of financing healthcare equipment.

    PubMed

    Bayless, M E; Diltz, J D

    1985-10-01

    Prospective payment has increased the importance of controlling capital costs. One area where this may be possible is lease financing. Reasons commonly cited in favor of leasing may be of questionable validity, but, under an easily identified set of circumstances, lease financing can be cost effective. Recent developments in finance make it possible to not only evaluate the financial attractiveness of a given lease, but also to accurately predict bounds within which the terms of the lease must fall. Hospital administrators armed with this information should be able to negotiate more favorable lease terms under given tax and economic environments. PMID:10273774

  5. Cost of Computer Searching

    ERIC Educational Resources Information Center

    Chenery, Peter J.

    1973-01-01

    The program described has the primary objective of making Federally generated technology and research information available to public and private agencies. Cost analysis, data banks, and search strategies are explained. (Author/DH)

  6. Marginal costing methods highlight the contributing cost of comorbid conditions in Medicare patients: a quasi-experimental case–control study of ischemic stroke costs

    PubMed Central

    2013-01-01

    Background Cost of illness studies are needed to provide estimates for input into cost-effectiveness studies and as information drivers to resource allocation. However, these studies often do not differentiate costs associated with the disease of interest and costs of co-morbidities. The goal of this study was to identify the 1-year cost of ischemic stroke compared to the annual cost of care for a comparable non-stroke group of South Carolina (SC) Medicare beneficiaries resulting in a marginal cost estimate. Methods SC data for 2004 and 2005 were used to estimate the mean 12 month cost of stroke for 2,976 Medicare beneficiaries hospitalized for Ischemic Stroke in 2004. Using nearest neighbor propensity score matching, a control group of non-stroke beneficiaries were matched on age, gender, race, risk factors, and Charlson comorbidity index and their costs were calculated. Marginal cost attributable to ischemic stroke was calculated as the difference between these two adjusted cost estimates. Results The total cost estimated for SC stroke patients for 1 year (2004) was $81.3 million. The cost for the matched comparison group without stroke was $54.4 million. Thus, the 2004 marginal costs to Medicare due to Ischemic stroke in SC are estimated to be $26.9 million. Conclusions Accurate estimates of cost of care for conditions, such as stroke, that are common in older patients with a high rate of comorbid conditions require the use of a marginal costing approach. Over estimation of cost of care for stroke may lead to prediction of larger savings than realizable from important stroke treatment and prevention programs, which may damage the credibility of program advocates, and jeopardize long term funding support. Additionally, correct cost estimates are needed as inputs for valid cost-effectiveness studies. Thus, it is important to use marginal costing for stroke, especially with the increasing public focus on evidence-based economic decision making to be expected with

  7. Measuring Fisher Information Accurately in Correlated Neural Populations

    PubMed Central

    Kohn, Adam; Pouget, Alexandre

    2015-01-01

    Neural responses are known to be variable. In order to understand how this neural variability constrains behavioral performance, we need to be able to measure the reliability with which a sensory stimulus is encoded in a given population. However, such measures are challenging for two reasons: First, they must take into account noise correlations which can have a large influence on reliability. Second, they need to be as efficient as possible, since the number of trials available in a set of neural recording is usually limited by experimental constraints. Traditionally, cross-validated decoding has been used as a reliability measure, but it only provides a lower bound on reliability and underestimates reliability substantially in small datasets. We show that, if the number of trials per condition is larger than the number of neurons, there is an alternative, direct estimate of reliability which consistently leads to smaller errors and is much faster to compute. The superior performance of the direct estimator is evident both for simulated data and for neuronal population recordings from macaque primary visual cortex. Furthermore we propose generalizations of the direct estimator which measure changes in stimulus encoding across conditions and the impact of correlations on encoding and decoding, typically denoted by Ishuffle and Idiag respectively. PMID:26030735

  8. An Analysis of Rocket Propulsion Testing Costs

    NASA Technical Reports Server (NTRS)

    Ramirez-Pagan, Carmen P.; Rahman, Shamim A.

    2009-01-01

    The primary mission at NASA Stennis Space Center (SSC) is rocket propulsion testing. Such testing is generally performed within two arenas: (1) Production testing for certification and acceptance, and (2) Developmental testing for prototype or experimental purposes. The customer base consists of NASA programs, DOD programs, and commercial programs. Resources in place to perform on-site testing include both civil servants and contractor personnel, hardware and software including data acquisition and control, and 6 test stands with a total of 14 test positions/cells. For several business reasons there is the need to augment understanding of the test costs for all the various types of test campaigns. Historical propulsion test data was evaluated and analyzed in many different ways with the intent to find any correlation or statistics that could help produce more reliable and accurate cost estimates and projections. The analytical efforts included timeline trends, statistical curve fitting, average cost per test, cost per test second, test cost timeline, and test cost envelopes. Further, the analytical effort includes examining the test cost from the perspective of thrust level and test article characteristics. Some of the analytical approaches did not produce evidence strong enough for further analysis. Some other analytical approaches yield promising results and are candidates for further development and focused study. Information was organized for into its elements: a Project Profile, Test Cost Timeline, and Cost Envelope. The Project Profile is a snap shot of the project life cycle on a timeline fashion, which includes various statistical analyses. The Test Cost Timeline shows the cumulative average test cost, for each project, at each month where there was test activity. The Test Cost Envelope shows a range of cost for a given number of test(s). The supporting information upon which this study was performed came from diverse sources and thus it was necessary to

  9. Measuring public hospital costs: empirical evidence from the Dominican Republic.

    PubMed

    Lewis, M A; La Forgia, G M; Sulvetta, M B

    1996-07-01

    Effective analysis of hospital performance requires the existence of accurate cost and output data. However, these are missing ingredients in most developing countries due to lack of information systems or other sources of data. Typically, expenditures are substituted for actual costs in analyzing hospital finance. This paper presents a methodology and analysis of the actual costs of inpatient, emergency, and outpatient services in a Dominican hospital. Through applying a set of survey instruments to a large sample of patients, the study measures and costs all hospital staff time, in-kind goods (drugs, medical supplies, reagents, etc.), overhead, and the depreciated value of plant and equipment related to the treatment of each patient. The results are striking. The budget is over 50% higher than the actual costs of services, reflecting the high cost of waste, down time, and low productivity. For example, high fixed costs translate into immunizations that on the average cost over 20% more than outpatient surgical interventions. The most disturbing finding is that although physicians represent the bulk of personnel spending, the surveys could account for only 12% of the contracted time of staff physicians, including time dedicated to treatment, supervision, administration, and teaching. As a proportion of the hospital total budget, personnel spending represents a high 84%. Yet staff costs for patient treatment never exceed 12%. These results suggest gross inefficiency, chaotic medical care organization, and poor hospital management. PMID:8844926

  10. Rapidly falling costs of battery packs for electric vehicles

    NASA Astrophysics Data System (ADS)

    Nykvist, Björn; Nilsson, Måns

    2015-04-01

    To properly evaluate the prospects for commercially competitive battery electric vehicles (BEV) one must have accurate information on current and predicted cost of battery packs. The literature reveals that costs are coming down, but with large uncertainties on past, current and future costs of the dominating Li-ion technology. This paper presents an original systematic review, analysing over 80 different estimates reported 2007-2014 to systematically trace the costs of Li-ion battery packs for BEV manufacturers. We show that industry-wide cost estimates declined by approximately 14% annually between 2007 and 2014, from above US$1,000 per kWh to around US$410 per kWh, and that the cost of battery packs used by market-leading BEV manufacturers are even lower, at US$300 per kWh, and has declined by 8% annually. Learning rate, the cost reduction following a cumulative doubling of production, is found to be between 6 and 9%, in line with earlier studies on vehicle battery technology. We reveal that the costs of Li-ion battery packs continue to decline and that the costs among market leaders are much lower than previously reported. This has significant implications for the assumptions used when modelling future energy and transport systems and permits an optimistic outlook for BEVs contributing to low-carbon transport.

  11. How flatbed scanners upset accurate film dosimetry.

    PubMed

    van Battum, L J; Huizenga, H; Verdaasdonk, R M; Heukelom, S

    2016-01-21

    Film is an excellent dosimeter for verification of dose distributions due to its high spatial resolution. Irradiated film can be digitized with low-cost, transmission, flatbed scanners. However, a disadvantage is their lateral scan effect (LSE): a scanner readout change over its lateral scan axis. Although anisotropic light scattering was presented as the origin of the LSE, this paper presents an alternative cause. Hereto, LSE for two flatbed scanners (Epson 1680 Expression Pro and Epson 10000XL), and Gafchromic film (EBT, EBT2, EBT3) was investigated, focused on three effects: cross talk, optical path length and polarization. Cross talk was examined using triangular sheets of various optical densities. The optical path length effect was studied using absorptive and reflective neutral density filters with well-defined optical characteristics (OD range 0.2-2.0). Linear polarizer sheets were used to investigate light polarization on the CCD signal in absence and presence of (un)irradiated Gafchromic film. Film dose values ranged between 0.2 to 9 Gy, i.e. an optical density range between 0.25 to 1.1. Measurements were performed in the scanner's transmission mode, with red-green-blue channels. LSE was found to depend on scanner construction and film type. Its magnitude depends on dose: for 9 Gy increasing up to 14% at maximum lateral position. Cross talk was only significant in high contrast regions, up to 2% for very small fields. The optical path length effect introduced by film on the scanner causes 3% for pixels in the extreme lateral position. Light polarization due to film and the scanner's optical mirror system is the main contributor, different in magnitude for the red, green and blue channel. We concluded that any Gafchromic EBT type film scanned with a flatbed scanner will face these optical effects. Accurate dosimetry requires correction of LSE, therefore, determination of the LSE per color channel and dose delivered to the film. PMID:26689962

  12. Important Nearby Galaxies without Accurate Distances

    NASA Astrophysics Data System (ADS)

    McQuinn, Kristen

    2014-10-01

    The Spitzer Infrared Nearby Galaxies Survey (SINGS) and its offspring programs (e.g., THINGS, HERACLES, KINGFISH) have resulted in a fundamental change in our view of star formation and the ISM in galaxies, and together they represent the most complete multi-wavelength data set yet assembled for a large sample of nearby galaxies. These great investments of observing time have been dedicated to the goal of understanding the interstellar medium, the star formation process, and, more generally, galactic evolution at the present epoch. Nearby galaxies provide the basis for which we interpret the distant universe, and the SINGS sample represents the best studied nearby galaxies.Accurate distances are fundamental to interpreting observations of galaxies. Surprisingly, many of the SINGS spiral galaxies have numerous distance estimates resulting in confusion. We can rectify this situation for 8 of the SINGS spiral galaxies within 10 Mpc at a very low cost through measurements of the tip of the red giant branch. The proposed observations will provide an accuracy of better than 0.1 in distance modulus. Our sample includes such well known galaxies as M51 (the Whirlpool), M63 (the Sunflower), M104 (the Sombrero), and M74 (the archetypal grand design spiral).We are also proposing coordinated parallel WFC3 UV observations of the central regions of the galaxies, rich with high-mass UV-bright stars. As a secondary science goal we will compare the resolved UV stellar populations with integrated UV emission measurements used in calibrating star formation rates. Our observations will complement the growing HST UV atlas of high resolution images of nearby galaxies.

  13. How flatbed scanners upset accurate film dosimetry

    NASA Astrophysics Data System (ADS)

    van Battum, L. J.; Huizenga, H.; Verdaasdonk, R. M.; Heukelom, S.

    2016-01-01

    Film is an excellent dosimeter for verification of dose distributions due to its high spatial resolution. Irradiated film can be digitized with low-cost, transmission, flatbed scanners. However, a disadvantage is their lateral scan effect (LSE): a scanner readout change over its lateral scan axis. Although anisotropic light scattering was presented as the origin of the LSE, this paper presents an alternative cause. Hereto, LSE for two flatbed scanners (Epson 1680 Expression Pro and Epson 10000XL), and Gafchromic film (EBT, EBT2, EBT3) was investigated, focused on three effects: cross talk, optical path length and polarization. Cross talk was examined using triangular sheets of various optical densities. The optical path length effect was studied using absorptive and reflective neutral density filters with well-defined optical characteristics (OD range 0.2-2.0). Linear polarizer sheets were used to investigate light polarization on the CCD signal in absence and presence of (un)irradiated Gafchromic film. Film dose values ranged between 0.2 to 9 Gy, i.e. an optical density range between 0.25 to 1.1. Measurements were performed in the scanner’s transmission mode, with red-green-blue channels. LSE was found to depend on scanner construction and film type. Its magnitude depends on dose: for 9 Gy increasing up to 14% at maximum lateral position. Cross talk was only significant in high contrast regions, up to 2% for very small fields. The optical path length effect introduced by film on the scanner causes 3% for pixels in the extreme lateral position. Light polarization due to film and the scanner’s optical mirror system is the main contributor, different in magnitude for the red, green and blue channel. We concluded that any Gafchromic EBT type film scanned with a flatbed scanner will face these optical effects. Accurate dosimetry requires correction of LSE, therefore, determination of the LSE per color channel and dose delivered to the film.

  14. Evaluation of matching cost on the ISPRS stereo matching benchmark

    NASA Astrophysics Data System (ADS)

    Yue, Qingxing; Tang, Xinming; Gao, Xiaoming

    2015-12-01

    In this paper we evaluated several typical matching costs including CENSUS, mutual information (MI) and the normalized cross correlation using the ISPRS Stereo Matching Benchmark datasets for DSM generation by stereo matching. Two kinds of global optimization algorithms including semi-global matching (SGM) and graph cuts (GC) were used as optimization method. We used a sub-pixel method to obtain more accurate MI lookup table and a sub-pixel method was also used when computing cost by MI lookup table. MI itself is sensitive to partial radiation differences. So we used a kind of cost combined MI and CENSUS. After DSM generation, the deviation data between the generated DSM and Lidar was statistics out to compute the mean deviation (Mean), the median deviation (Med), the standard deviation (Stdev), the normalized median absolute deviation (NMAD), the percentage of deviation in tolerance etc., which were used to evaluate the accuracy of DSM generated from different cost.

  15. Second EPA (Environmental Protection Agency) evaluation of the POLARION-X device under Section 511 of the Motor Vehicle Information and Cost Savings Act. Technical report

    SciTech Connect

    Barth, E.A.

    1985-04-01

    The document announces the conclusions of the EPA evaluation of the POLARION-X device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The second evaluation of the POLARION-X device was conducted upon receiving an application for evaluation from the marketer of the device. The device is a fuel magnet. It is claimed to reduce emissions, to improve fuel economy and performance, to provide more complete combustion, to eliminate engine carbon buildup and dieseling, and to reduce the octane requirements of the engine. EPA fully considered all of the previous correspondence and analyses that were incorporated in the prior evaluation. In addition, the intervening correspondence about the device and test fuel are also considered to apply to the application. The net result is that, except for the test data, the previous submission and the analyses of it are essentially unchanged. Based on engineering judgment and the results of test data, it is concluded that the POLARION-X device will not improve emissions or fuel economy.

  16. Second EPA evaluation of the Platinum Gasaver Device under Section 511 of the Motor Vehicle Information and Cost Savings Act (updated). Technical report

    SciTech Connect

    Not Available

    1991-07-01

    The report announces the conclusions of the EPA evaluation of the Platinum Gasaver Device under the provisions of Section 511 of the Motor Vehicle Information and Cost Savings Act. The second evaluation of the Platinum Gasaver device was conducted upon the request of the Federal Trade Commission. The unit is a vapor bleed device. It functions by bleeding a mixture of air and 'platinum concentrate' through a 'T' connection that is installed in the Positive Crankcase Ventilation (PCV) line. It is claimed to reduce emissions, improve fuel economy, raise the octane of gasoline, and extend engine line. Three typical vehicles were tested at the EPA's Motor Vehicle Emission Laboratory. The basic test sequence included 2,000 miles of mileage accumulation, replicate Federal Test Procedures (FTP) and replicate Highway Fuel Economy Tests (HFET). The test sequence was conducted both without and with the Platinum Gasaver installed. The overall conclusion from these tests is that the Platinum Gasaver device did not significantly change vehicle emissions or fuel economy for either the FTP or the HFET.

  17. Low-Cost Spectral Sensor Development Description.

    SciTech Connect

    Armijo, Kenneth Miguel; Yellowhair, Julius

    2014-11-01

    Solar spectral data for all parts of the US is limited due in part to the high cost of commercial spectrometers. Solar spectral information is necessary for accurate photovoltaic (PV) performance forecasting, especially for large utility-scale PV installations. A low-cost solar spectral sensor would address the obstacles and needs. In this report, a novel low-cost, discrete- band sensor device, comprised of five narrow-band sensors, is described. The hardware is comprised of commercial-off-the-shelf components to keep the cost low. Data processing algorithms were developed and are being refined for robustness. PV module short-circuit current ( I sc ) prediction methods were developed based on interaction-terms regression methodology and spectrum reconstruction methodology for computing I sc . The results suggest the computed spectrum using the reconstruction method agreed well with the measured spectrum from the wide-band spectrometer (RMS error of 38.2 W/m 2 -nm). Further analysis of computed I sc found a close correspondence of 0.05 A RMS error. The goal is for ubiquitous adoption of the low-cost spectral sensor in solar PV and other applications such as weather forecasting.

  18. Accurate lineshape spectroscopy and the Boltzmann constant

    PubMed Central

    Truong, G.-W.; Anstie, J. D.; May, E. F.; Stace, T. M.; Luiten, A. N.

    2015-01-01

    Spectroscopy has an illustrious history delivering serendipitous discoveries and providing a stringent testbed for new physical predictions, including applications from trace materials detection, to understanding the atmospheres of stars and planets, and even constraining cosmological models. Reaching fundamental-noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here, we demonstrate a quantum-limited spectrometer that delivers high-precision measurements of the absorption lineshape. These measurements yield a very accurate measurement of the excited-state (6P1/2) hyperfine splitting in Cs, and reveals a breakdown in the well-known Voigt spectral profile. We develop a theoretical model that accounts for this breakdown, explaining the observations to within the shot-noise limit. Our model enables us to infer the thermal velocity dispersion of the Cs vapour with an uncertainty of 35 p.p.m. within an hour. This allows us to determine a value for Boltzmann's constant with a precision of 6 p.p.m., and an uncertainty of 71 p.p.m. PMID:26465085

  19. Accurate lineshape spectroscopy and the Boltzmann constant.

    PubMed

    Truong, G-W; Anstie, J D; May, E F; Stace, T M; Luiten, A N

    2015-01-01

    Spectroscopy has an illustrious history delivering serendipitous discoveries and providing a stringent testbed for new physical predictions, including applications from trace materials detection, to understanding the atmospheres of stars and planets, and even constraining cosmological models. Reaching fundamental-noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here, we demonstrate a quantum-limited spectrometer that delivers high-precision measurements of the absorption lineshape. These measurements yield a very accurate measurement of the excited-state (6P1/2) hyperfine splitting in Cs, and reveals a breakdown in the well-known Voigt spectral profile. We develop a theoretical model that accounts for this breakdown, explaining the observations to within the shot-noise limit. Our model enables us to infer the thermal velocity dispersion of the Cs vapour with an uncertainty of 35 p.p.m. within an hour. This allows us to determine a value for Boltzmann's constant with a precision of 6 p.p.m., and an uncertainty of 71 p.p.m. PMID:26465085

  20. Tracking Costs

    ERIC Educational Resources Information Center

    Erickson, Paul W.

    2010-01-01

    Even though there's been a slight reprieve in energy costs, the reality is that the cost of non-renewable energy is increasing, and state education budgets are shrinking. One way to keep energy and operations costs from overshadowing education budgets is to develop a 10-year energy audit plan to eliminate waste. First, facility managers should…

  1. Activity-based costing for electric utilities. Final report

    SciTech Connect

    Croyle, D.R.; Schapiro, I.A.; Keglevic, P.M.

    1992-08-01

    This EPRI report is a ``primer`` on Activity-Based Costing (ABC). ABC is a cost management aproach which can make an important contribution to understanding and controlling the changing costs in the electric utility industry. It is a method for attributing costs to activities, products and services by better understanding the underlying factors which drive those costs. ABC can help utility managers make better decisions through the application of more accurate process and product cost information and a fuller understanding of which activities add value and which do not. Armed with such information, utility managers are better equipped to address many of the strategic and operating decisions which they routinely face. The report introduces the ABC concept and approach to utility managers and offers insights into how ABC can be and is being used to control costs and improve strategic and operating decisions in electric utilities and other industries. The report (1) describes the ABC approach, (2) discusses the value of ABC to elecuic utilities, (3) identifies potential applications of ABC to current utility issues, (4) describes a step-by-step approach to developing and implementing ABC in the utility environment, and (5) presents a survey of more than 30 electric utilities and several detailed case studies of electric utilities and other companies who have adopted and are using ABC.

  2. Cost accounting of radiological examinations. Cost analysis of radiological examinations of intermediate referral hospitals and general practice.

    PubMed

    Lääperi, A L

    1996-01-01

    nonmonetary variables was developed. In it the radiologist, radiographer and examination-specific equipment costs were allocated to the examinations applying estimated cost equivalents. Some minor cost items were replaced by a general cost factor (GCF). The program is suitable for internal cost accounting of radiological departments as well as regional planning. If more accurate cost information is required, cost assignment employing the actual consumption of the resources and applying the principles of activity-based cost accounting is recommended. As an application of the cost accounting formula the average costs of the radiological examinations were calculated. In conventional radiography the average proportion of the cost factors in the total material was: personnel costs 43%, equipment costs 26%, material costs 7%, real estate costs 11%, administration and overheads 14%. The average total costs including radiologist costs in the hospitals were (FIM): conventional roentgen examinations 188, contrast medium examinations 695, ultrasound 296, mammography 315, roentgen examinations with mobile equipment 1578. The average total costs without radiologist costs in the public health centres were (FIM): conventional roentgen examinations 107, contrast medium examinations 988, ultrasound 203, mammography 557. The average currency rate of exchange in 1991 was USD 1 = FIM 4.046. The following formula is proposed for calculating the cost of a radiological examination (or a group of examinations) performed with a certain piece of equipment during a period of time (e.g. 1 year): a2/ sigma ax*ax+ b2/ sigma bx*bx+ d1/d5*dx+ e1 + [(c1+ c2) + d4 + (e2 - e3) + f5 + g1+ g2+ i]/n. PMID:8804226

  3. Determination of chest x-ray cost using activity based costing approach at Penang General Hospital, Malaysia

    PubMed Central

    Atif, Muhammad; Sulaiman, Syed Azhar Syed; Shafie, Asrul Akmal; Saleem, Fahad; Ahmad, Nafees

    2012-01-01

    Background Activity based costing (ABC) is an approach to get insight of true costs and to solve accounting problems. It provides more accurate information on product cost than conventional accounting system. The purpose of this study was to identify detailed resource consumption for chest x-ray procedure. Methods Human resource cost was calculated by multiplying the mean time spent by employees doing specific activity to their per-minute salaries. The costs of consumables and clinical equipments were obtained from the procurement section of the Radiology Department. The cost of the building was calculated by multiplying the area of space used by the chest X-ray facility with the unit cost of public building department. Moreover, straight-line deprecation with a discount rate of 3% was assumed for calculation of equivalent annual costs for building and machines. Cost of electricity was calculated by multiplying number of kilo watts used by electrical appliance in the year 2010 with electricity tariff for Malaysian commercial consumers (MYR 0.31 per kWh). Results Five activities were identified which were required to develop one chest X-ray film. Human resource, capital, consumable and electricity cost was MYR 1.48, MYR 1.98, MYR 2.15 and MYR 0.04, respectively. Total cost of single chest X-ray was MYR 5.65 (USD 1.75). Conclusion By applying ABC approach, we can have more detailed and precise estimate of cost for specific activity or service. Choice of repeating a chest X-ray can be based on our findings, when cost is a limiting factor. PMID:22891098

  4. Portuguese Family Physicians’ Awareness of Diagnostic and Laboratory Test Costs: A Cross-Sectional Study

    PubMed Central

    Sá, Luísa; Costa-Santos, Cristina; Teixeira, Andreia; Couto, Luciana; Costa-Pereira, Altamiro; Hespanhol, Alberto; Santos, Paulo; Martins, Carlos

    2015-01-01

    Background Physicians’ ability to make cost-effective decisions has been shown to be affected by their knowledge of health care costs. This study assessed whether Portuguese family physicians are aware of the costs of the most frequently prescribed diagnostic and laboratory tests. Methods A cross-sectional study was conducted in a representative sample of Portuguese family physicians, using computer-assisted telephone interviews for data collection. A Likert scale was used to assess physician’s level of agreement with four statements about health care costs. Family physicians were also asked to estimate the costs of diagnostic and laboratory tests. Each physician’s cost estimate was compared with the true cost and the absolute error was calculated. Results One-quarter (24%; 95% confidence interval: 23%–25%) of all cost estimates were accurate to within 25% of the true cost, with 55% (95% IC: 53–56) overestimating and 21% (95% IC: 20–22) underestimating the true actual cost. The majority (76%) of family physicians thought they did not have or were uncertain as to whether they had adequate knowledge of diagnostic and laboratory test costs, and only 7% reported receiving adequate education. The majority of the family physicians (82%) said that they had adequate access to information about the diagnostic and laboratory test costs. Thirty-three percent thought that costs did not influence their decision to order tests, while 27% were uncertain. Conclusions Portuguese family physicians have limited awareness of diagnostic and laboratory test costs, and our results demonstrate a need for improved education in this area. Further research should focus on identifying whether interventions in cost knowledge actually change ordering behavior, in identifying optimal methods to disseminate cost information, and on improving the cost-effectiveness of care. PMID:26356625

  5. DR-TAMAS: Diffeomorphic Registration for Tensor Accurate Alignment of Anatomical Structures.

    PubMed

    Irfanoglu, M Okan; Nayak, Amritha; Jenkins, Jeffrey; Hutchinson, Elizabeth B; Sadeghi, Neda; Thomas, Cibu P; Pierpaoli, Carlo

    2016-05-15

    In this work, we propose DR-TAMAS (Diffeomorphic Registration for Tensor Accurate alignMent of Anatomical Structures), a novel framework for intersubject registration of Diffusion Tensor Imaging (DTI) data sets. This framework is optimized for brain data and its main goal is to achieve an accurate alignment of all brain structures, including white matter (WM), gray matter (GM), and spaces containing cerebrospinal fluid (CSF). Currently most DTI-based spatial normalization algorithms emphasize alignment of anisotropic structures. While some diffusion-derived metrics, such as diffusion anisotropy and tensor eigenvector orientation, are highly informative for proper alignment of WM, other tensor metrics such as the trace or mean diffusivity (MD) are fundamental for a proper alignment of GM and CSF boundaries. Moreover, it is desirable to include information from structural MRI data, e.g., T1-weighted or T2-weighted images, which are usually available together with the diffusion data. The fundamental property of DR-TAMAS is to achieve global anatomical accuracy by incorporating in its cost function the most informative metrics locally. Another important feature of DR-TAMAS is a symmetric time-varying velocity-based transformation model, which enables it to account for potentially large anatomical variability in healthy subjects and patients. The performance of DR-TAMAS is evaluated with several data sets and compared with other widely-used diffeomorphic image registration techniques employing both full tensor information and/or DTI-derived scalar maps. Our results show that the proposed method has excellent overall performance in the entire brain, while being equivalent to the best existing methods in WM. PMID:26931817

  6. Spacecraft platform cost estimating relationships

    NASA Technical Reports Server (NTRS)

    Gruhl, W. M.

    1972-01-01

    The three main cost areas of unmanned satellite development are discussed. The areas are identified as: (1) the spacecraft platform (SCP), (2) the payload or experiments, and (3) the postlaunch ground equipment and operations. The SCP normally accounts for over half of the total project cost and accurate estimates of SCP costs are required early in project planning as a basis for determining total project budget requirements. The development of single formula SCP cost estimating relationships (CER) from readily available data by statistical linear regression analysis is described. The advantages of single formula CER are presented.

  7. 28 CFR 100.15 - Disallowed costs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST RECOVERY REGULATIONS, COMMUNICATIONS...) costs are disallowed. G&A costs include, but are not limited to, any management, financial, and other... limited to: (1) Accounting and Finance, External Relations, Human Resources, Information Management,...

  8. 28 CFR 100.15 - Disallowed costs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST RECOVERY REGULATIONS, COMMUNICATIONS...) costs are disallowed. G&A costs include, but are not limited to, any management, financial, and other... limited to: (1) Accounting and Finance, External Relations, Human Resources, Information Management,...

  9. Point-of-Care CD4 Testing to Inform Selection of Antiretroviral Medications in South African Antenatal Clinics: A Cost-Effectiveness Analysis

    PubMed Central

    Ciaranello, Andrea L.; Myer, Landon; Kelly, Kathleen; Christensen, Sarah; Daskilewicz, Kristen; Doherty, Katie; Bekker, Linda-Gail; Hou, Taige; Wood, Robin; Francke, Jordan A.; Wools-Kaloustian, Kara; Freedberg, Kenneth A.; Walensky, Rochelle P.

    2015-01-01

    Background Many prevention of mother-to-child HIV transmission (PMTCT) programs currently prioritize antiretroviral therapy (ART) for women with advanced HIV. Point-of-care (POC) CD4 assays may expedite the selection of three-drug ART instead of zidovudine, but are costlier than traditional laboratory assays. Methods We used validated models of HIV infection to simulate pregnant, HIV-infected women (mean age 26 years, gestational age 26 weeks) in a general antenatal clinic in South Africa, and their infants. We examined two strategies for CD4 testing after HIV diagnosis: laboratory (test rate: 96%, result-return rate: 87%, cost: $14) and POC (test rate: 99%, result-return rate: 95%, cost: $26). We modeled South African PMTCT guidelines during the study period (WHO “Option A”): antenatal zidovudine (CD4 ≤350/μL) or ART (CD4>350/μL). Outcomes included MTCT risk at weaning (age 6 months), maternal and pediatric life expectancy (LE), maternal and pediatric lifetime healthcare costs (2013 USD), and cost-effectiveness ($/life-year saved). Results In the base case, laboratory led to projected MTCT risks of 5.7%, undiscounted pediatric LE of 53.2 years, and undiscounted PMTCT plus pediatric lifetime costs of $1,070/infant. POC led to lower modeled MTCT risk (5.3%), greater pediatric LE (53.4 years) and lower PMTCT plus pediatric lifetime costs ($1,040/infant). Maternal outcomes following laboratory were similar to POC (LE: 21.2 years; lifetime costs: $23,860/person). Compared to laboratory, POC improved clinical outcomes and reduced healthcare costs. Conclusions In antenatal clinics implementing Option A, the higher initial cost of a one-time POC CD4 assay will be offset by cost-savings from prevention of pediatric HIV infection. PMID:25756498

  10. Cost Differential Analysis: Providing Data for Added Cost Funding

    ERIC Educational Resources Information Center

    Nystrom, Dennis C.; Hennessy, James V.

    1975-01-01

    A 1972-73 statewide study conducted in Illinois to develop a cost accounting system which facilitates cost differential ratios for secondary vocational education courses indicated that vocational programs are approximately twice as expensive as nonvocational. Specific cost elements identified in the study provided essential information regarding…

  11. Older Adults Seeking Healthcare Information on the Internet

    ERIC Educational Resources Information Center

    Hardt, Jeffrey H.; Hollis-Sawyer, Lisa

    2007-01-01

    Due to an aging population and increases in healthcare costs, particular attention needs to be focused on developing Internet sites that provide older adults with credible and accurate healthcare information. Present research findings suggest that motivation is only one factor that influences whether or not older adults utilize the World Wide Web…

  12. Nonexposure accurate location K-anonymity algorithm in LBS.

    PubMed

    Jia, Jinying; Zhang, Fengli

    2014-01-01

    This paper tackles location privacy protection in current location-based services (LBS) where mobile users have to report their exact location information to an LBS provider in order to obtain their desired services. Location cloaking has been proposed and well studied to protect user privacy. It blurs the user's accurate coordinate and replaces it with a well-shaped cloaked region. However, to obtain such an anonymous spatial region (ASR), nearly all existent cloaking algorithms require knowing the accurate locations of all users. Therefore, location cloaking without exposing the user's accurate location to any party is urgently needed. In this paper, we present such two nonexposure accurate location cloaking algorithms. They are designed for K-anonymity, and cloaking is performed based on the identifications (IDs) of the grid areas which were reported by all the users, instead of directly on their accurate coordinates. Experimental results show that our algorithms are more secure than the existent cloaking algorithms, need not have all the users reporting their locations all the time, and can generate smaller ASR. PMID:24605060

  13. Nonexposure Accurate Location K-Anonymity Algorithm in LBS

    PubMed Central

    2014-01-01

    This paper tackles location privacy protection in current location-based services (LBS) where mobile users have to report their exact location information to an LBS provider in order to obtain their desired services. Location cloaking has been proposed and well studied to protect user privacy. It blurs the user's accurate coordinate and replaces it with a well-shaped cloaked region. However, to obtain such an anonymous spatial region (ASR), nearly all existent cloaking algorithms require knowing the accurate locations of all users. Therefore, location cloaking without exposing the user's accurate location to any party is urgently needed. In this paper, we present such two nonexposure accurate location cloaking algorithms. They are designed for K-anonymity, and cloaking is performed based on the identifications (IDs) of the grid areas which were reported by all the users, instead of directly on their accurate coordinates. Experimental results show that our algorithms are more secure than the existent cloaking algorithms, need not have all the users reporting their locations all the time, and can generate smaller ASR. PMID:24605060

  14. Variation in the costs of delivering routine immunization services in Peru.

    PubMed Central

    Walker, D.; Mosqueira, N. R.; Penny, M. E.; Lanata, C. F.; Clark, A. D.; Sanderson, C. F. B.; Fox-Rushby, J. A.

    2004-01-01

    OBJECTIVE: Estimates of vaccination costs usually provide only point estimates at national level with no information on cost variation. In practice, however, such information is necessary for programme managers. This paper presents information on the variations in costs of delivering routine immunization services in three diverse districts of Peru: Ayacucho (a mountainous area), San Martin (a jungle area) and Lima (a coastal area). METHODS: We consider the impact of variability on predictions of cost and reflect on the likely impact on expected cost-effectiveness ratios, policy decisions and future research practice. All costs are in 2002 prices in US dollars and include the costs of providing vaccination services incurred by 19 government health facilities during the January-December 2002 financial year. Vaccine wastage rates have been estimated using stock records. FINDINGS: The cost per fully vaccinated child ranged from 16.63-24.52 U.S. Dollars in Ayacucho, 21.79-36.69 U.S. Dollars in San Martin and 9.58-20.31 U.S. Dollars in Lima. The volume of vaccines administered and wastage rates are determinants of the variation in costs of delivering routine immunization services. CONCLUSION: This study shows there is considerable variation in the costs of providing vaccines across geographical regions and different types of facilities. Information on how costs vary can be used as a basis from which to generalize to other settings and provide more accurate estimates for decision-makers who do not have disaggregated data on local costs. Future studies should include sufficiently large sample sizes and ensure that regions are carefully selected in order to maximize the interpretation of cost variation. PMID:15628205

  15. Avoidable waste management costs

    SciTech Connect

    Hsu, K.; Burns, M.; Priebe, S.; Robinson, P.

    1995-01-01

    This report describes the activity based costing method used to acquire variable (volume dependent or avoidable) waste management cost data for routine operations at Department of Energy (DOE) facilities. Waste volumes from environmental restoration, facility stabilization activities, and legacy waste were specifically excluded from this effort. A core team consisting of Idaho National Engineering Laboratory, Los Alamos National Laboratory, Rocky Flats Environmental Technology Site, and Oak Ridge Reservation developed and piloted the methodology, which can be used to determine avoidable waste management costs. The method developed to gather information was based on activity based costing, which is a common industrial engineering technique. Sites submitted separate flow diagrams that showed the progression of work from activity to activity for each waste type or treatability group. Each activity on a flow diagram was described in a narrative, which detailed the scope of the activity. Labor and material costs based on a unit quantity of waste being processed were then summed to generate a total cost for that flow diagram. Cross-complex values were calculated by determining a weighted average for each waste type or treatability group based on the volume generated. This study will provide DOE and contractors with a better understanding of waste management processes and their associated costs. Other potential benefits include providing cost data for sites to perform consistent cost/benefit analysis of waste minimization and pollution prevention (WMIN/PP) options identified during pollution prevention opportunity assessments and providing a means for prioritizing and allocating limited resources for WMIN/PP.

  16. Mill profiler machines soft materials accurately

    NASA Technical Reports Server (NTRS)

    Rauschl, J. A.

    1966-01-01

    Mill profiler machines bevels, slots, and grooves in soft materials, such as styrofoam phenolic-filled cores, to any desired thickness. A single operator can accurately control cutting depths in contour or straight line work.

  17. Remote balance weighs accurately amid high radiation

    NASA Technical Reports Server (NTRS)

    Eggenberger, D. N.; Shuck, A. B.

    1969-01-01

    Commercial beam-type balance, modified and outfitted with electronic controls and digital readout, can be remotely controlled for use in high radiation environments. This allows accurate weighing of breeder-reactor fuel pieces when they are radioactively hot.

  18. Understanding the Code: keeping accurate records.

    PubMed

    Griffith, Richard

    2015-10-01

    In his continuing series looking at the legal and professional implications of the Nursing and Midwifery Council's revised Code of Conduct, Richard Griffith discusses the elements of accurate record keeping under Standard 10 of the Code. This article considers the importance of accurate record keeping for the safety of patients and protection of district nurses. The legal implications of records are explained along with how district nurses should write records to ensure these legal requirements are met. PMID:26418404

  19. Troubleshooting Costs

    NASA Astrophysics Data System (ADS)

    Kornacki, Jeffrey L.

    Seventy-six million cases of foodborne disease occur each year in the United States alone. Medical and lost productivity costs of the most common pathogens are estimated to be 5.6-9.4 billion. Product recalls, whether from foodborne illness or spoilage, result in added costs to manufacturers in a variety of ways. These may include expenses associated with lawsuits from real or allegedly stricken individuals and lawsuits from shorted customers. Other costs include those associated with efforts involved in finding the source of the contamination and eliminating it and include time when lines are shut down and therefore non-productive, additional non-routine testing, consultant fees, time and personnel required to overhaul the entire food safety system, lost market share to competitors, and the cost associated with redesign of the factory and redesign or acquisition of more hygienic equipment. The cost associated with an effective quality assurance plan is well worth the effort to prevent the situations described.

  20. Information logistics: A production-line approach to information services

    NASA Technical Reports Server (NTRS)

    Adams, Dennis; Lee, Chee-Seng

    1991-01-01

    Logistics can be defined as the process of strategically managing the acquisition, movement, and storage of materials, parts, and finished inventory (and the related information flow) through the organization and its marketing channels in a cost effective manner. It is concerned with delivering the right product to the right customer in the right place at the right time. The logistics function is composed of inventory management, facilities management, communications unitization, transportation, materials management, and production scheduling. The relationship between logistics and information systems is clear. Systems such as Electronic Data Interchange (EDI), Point of Sale (POS) systems, and Just in Time (JIT) inventory management systems are important elements in the management of product development and delivery. With improved access to market demand figures, logisticians can decrease inventory sizes and better service customer demand. However, without accurate, timely information, little, if any, of this would be feasible in today's global markets. Information systems specialists can learn from logisticians. In a manner similar to logistics management, information logistics is concerned with the delivery of the right data, to the ring customer, at the right time. As such, information systems are integral components of the information logistics system charged with providing customers with accurate, timely, cost-effective, and useful information. Information logistics is a management style and is composed of elements similar to those associated with the traditional logistics activity: inventory management (data resource management), facilities management (distributed, centralized and decentralized information systems), communications (participative design and joint application development methodologies), unitization (input/output system design, i.e., packaging or formatting of the information), transportations (voice, data, image, and video communication systems

  1. The Yale Cost Model and cost centres: servant or master?

    PubMed

    Rigby, E

    1993-01-01

    Cost accounting describes that aspect of accounting which collects, allocates and controls the cost of producing a service. Costing information is primarily reported to management to enable control of costs and to ensure the financial viability of units, departments and divisions. As costing studies continue to produce estimates of Diagnosis Related Group (DRG) costs in New South Wales hospitals, as well as in other states, costs for different hospitals are being externally compared, using a tool which is usually related to internal management and reporting. Comparability of costs is assumed even though accounting systems differ. This paper examines the cost centre structures at five major teaching hospitals in Sydney. It describes the similarities and differences in how the cost centres were constituted, and then details the line items of expenditure that are charged to each cost centre. The results of a comparative study of a medical specialty are included as evidence of different costing methodologies in the hospitals. The picture that emerged from the study is that the hospitals are constituting their cost centres to meet their internal management needs, that is, to know the cost of running a ward or nursing unit, a medical specialty, department and so on. The rationale for the particular cost centre construction was that cost centre managers could manage and control costs and assign responsibility. There are variations in procedures for assigning costs to cost centres, and the question is asked 'Do these variations in procedures make a material difference to our ability to compare costs per Diagnosis Related Group at the various hospitals?' It is contended that the accounting information, which is produced as a result of different practices, is primarily for internal management, not external comparison. It would be better for hospitals to compare their estimated costs per Diagnosis Related Group to an internal standard cost rather than the costs from other

  2. Closing the mental health treatment gap in South Africa: a review of costs and cost-effectiveness

    PubMed Central

    Jack, Helen; Wagner, Ryan G.; Petersen, Inge; Thom, Rita; Newton, Charles R.; Stein, Alan; Kahn, Kathleen; Tollman, Stephen; Hofman, Karen J.

    2014-01-01

    Background Nearly one in three South Africans will suffer from a mental disorder in his or her lifetime, a higher prevalence than many low- and middle-income countries. Understanding the economic costs and consequences of prevention and packages of care is essential, particularly as South Africa considers scaling-up mental health services and works towards universal health coverage. Economic evaluations can inform how priorities are set in system or spending changes. Objective To identify and review research from South Africa and sub-Saharan Africa on the direct and indirect costs of mental, neurological, and substance use (MNS) disorders and the cost-effectiveness of treatment interventions. Design Narrative overview methodology. Results and conclusions Reviewed studies indicate that integrating mental health care into existing health systems may be the most effective and cost-efficient approach to increase access to mental health services in South Africa. Integration would also direct treatment, prevention, and screening to people with HIV and other chronic health conditions who are at high risk for mental disorders. We identify four major knowledge gaps: 1) accurate and thorough assessment of the health burdens of MNS disorders, 2) design and assessment of interventions that integrate mental health screening and treatment into existing health systems, 3) information on the use and costs of traditional medicines, and 4) cost-effectiveness evaluation of a range of specific interventions or packages of interventions that are tailored to the national context. PMID:24848654

  3. Leveraging Two Kinect Sensors for Accurate Full-Body Motion Capture

    PubMed Central

    Gao, Zhiquan; Yu, Yao; Zhou, Yu; Du, Sidan

    2015-01-01

    Accurate motion capture plays an important role in sports analysis, the medical field and virtual reality. Current methods for motion capture often suffer from occlusions, which limits the accuracy of their pose estimation. In this paper, we propose a complete system to measure the pose parameters of the human body accurately. Different from previous monocular depth camera systems, we leverage two Kinect sensors to acquire more information about human movements, which ensures that we can still get an accurate estimation even when significant occlusion occurs. Because human motion is temporally constant, we adopt a learning analysis to mine the temporal information across the posture variations. Using this information, we estimate human pose parameters accurately, regardless of rapid movement. Our experimental results show that our system can perform an accurate pose estimation of the human body with the constraint of information from the temporal domain. PMID:26402681

  4. Leveraging Two Kinect Sensors for Accurate Full-Body Motion Capture.

    PubMed

    Gao, Zhiquan; Yu, Yao; Zhou, Yu; Du, Sidan

    2015-01-01

    Accurate motion capture plays an important role in sports analysis, the medical field and virtual reality. Current methods for motion capture often suffer from occlusions, which limits the accuracy of their pose estimation. In this paper, we propose a complete system to measure the pose parameters of the human body accurately. Different from previous monocular depth camera systems, we leverage two Kinect sensors to acquire more information about human movements, which ensures that we can still get an accurate estimation even when significant occlusion occurs. Because human motion is temporally constant, we adopt a learning analysis to mine the temporal information across the posture variations. Using this information, we estimate human pose parameters accurately, regardless of rapid movement. Our experimental results show that our system can perform an accurate pose estimation of the human body with the constraint of information from the temporal domain. PMID:26402681

  5. 36 CFR 254.7 - Assumption of costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; cultural resource surveys and mitigation; hazardous substance surveys and controls; removal of encumbrances... accurately reflects the value of the cost or service provided, or any responsibility and requirement...

  6. Comprehensive cost analysis of sentinel node biopsy in solid head and neck tumors using a time-driven activity-based costing approach.

    PubMed

    Crott, Ralph; Lawson, Georges; Nollevaux, Marie-Cécile; Castiaux, Annick; Krug, Bruno

    2016-09-01

    Head and neck cancer (HNC) is predominantly a locoregional disease. Sentinel lymph node (SLN) biopsy offers a minimally invasive means of accurately staging the neck. Value in healthcare is determined by both outcomes and the costs associated with achieving them. Time-driven activity-based costing (TDABC) may offer more precise estimates of the true cost. Process maps were developed for nuclear medicine, operating room and pathology care phases. TDABC estimates the costs by combining information about the process with the unit cost of each resource used. Resource utilization is based on observation of care and staff interviews. Unit costs are calculated as a capacity cost rate, measured as a Euros/min (2014), for each resource consumed. Multiplying together the unit costs and resource quantities and summing across all resources used will produce the average cost for each phase of care. Three time equations with six different scenarios were modeled based on the type of camera, the number of SLN and the type of staining used. Total times for different SLN scenarios vary between 284 and 307 min, respectively, with a total cost between 2794 and 3541€. The unit costs vary between 788€/h for the intraoperative evaluation with a gamma-probe and 889€/h for a preoperative imaging with a SPECT/CT. The unit costs for the lymphadenectomy and the pathological examination are, respectively, 560 and 713€/h. A 10 % increase of time per individual activity generates only 1 % change in the total cost. TDABC evaluates the cost of SLN in HNC. The total costs across all phases which varied between 2761 and 3744€ per standard case. PMID:27170361

  7. 20 CFR 641.859 - What other special rules govern the classification of costs as administrative costs or program...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... information; (2) Employment statistics information, including job listing information, job skills information...), all costs incurred by vendors are program costs. (See 29 CFR 99.210 for a discussion of...

  8. PRIMAL: Fast and Accurate Pedigree-based Imputation from Sequence Data in a Founder Population

    PubMed Central

    Livne, Oren E.; Han, Lide; Alkorta-Aranburu, Gorka; Wentworth-Sheilds, William; Abney, Mark; Ober, Carole; Nicolae, Dan L.

    2015-01-01

    Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm), a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL incorporates both existing and original ideas, such as a novel indexing strategy of Identity-By-Descent (IBD) segments based on clique graphs. We were able to impute the genomes of 1,317 South Dakota Hutterites, who had genome-wide genotypes for ~300,000 common single nucleotide variants (SNVs), from 98 whole genome sequences. Using a combination of pedigree-based and LD-based imputation, we were able to assign 87% of genotypes with >99% accuracy over the full range of allele frequencies. Using the IBD cliques we were also able to infer the parental origin of 83% of alleles, and genotypes of deceased recent ancestors for whom no genotype information was available. This imputed data set will enable us to better study the relative contribution of rare and common variants on human phenotypes, as well as parental origin effect of disease risk alleles in >1,000 individuals at minimal cost. PMID:25735005

  9. A highly accurate interatomic potential for argon

    NASA Astrophysics Data System (ADS)

    Aziz, Ronald A.

    1993-09-01

    A modified potential based on the individually damped model of Douketis, Scoles, Marchetti, Zen, and Thakkar [J. Chem. Phys. 76, 3057 (1982)] is presented which fits, within experimental error, the accurate ultraviolet (UV) vibration-rotation spectrum of argon determined by UV laser absorption spectroscopy by Herman, LaRocque, and Stoicheff [J. Chem. Phys. 89, 4535 (1988)]. Other literature potentials fail to do so. The potential also is shown to predict a large number of other properties and is probably the most accurate characterization of the argon interaction constructed to date.

  10. How Can It Cost That Much? A Three-Year Study of Proposal Production Costs.

    ERIC Educational Resources Information Center

    Wiese, W. C.; Bowden, C. Mal

    1997-01-01

    Examines significant new business proposal efforts for United States Department of Defense contracts. Identifies six "pillars" of a contractor's proposal preparation costs. Derives a formula that characterizes proposal preparation costs. Demonstrates that a quick, accurate cost model can be developed for proposal publishing. (RS)

  11. 36 CFR 254.7 - Assumption of costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following circumstances exist: (1) The amount of such cost assumed or compensation is reasonable and accurately reflects the value of the cost or service provided, or any responsibility and requirement...

  12. 36 CFR 254.7 - Assumption of costs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... following circumstances exist: (1) The amount of such cost assumed or compensation is reasonable and accurately reflects the value of the cost or service provided, or any responsibility and requirement...

  13. 36 CFR 254.7 - Assumption of costs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... following circumstances exist: (1) The amount of such cost assumed or compensation is reasonable and accurately reflects the value of the cost or service provided, or any responsibility and requirement...

  14. 36 CFR 254.7 - Assumption of costs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... following circumstances exist: (1) The amount of such cost assumed or compensation is reasonable and accurately reflects the value of the cost or service provided, or any responsibility and requirement...

  15. A systematic review of the unit costs of allied health and community services used by older people in Australia

    PubMed Central

    2013-01-01

    Background An economic evaluation of interventions for older people requires accurate assessment of costing and consideration of both acute and long-term services. Accurate information on the unit cost of allied health and community services is not readily available in Australia however. This systematic review therefore aims to synthesise information available in the literature on the unit costs of allied health and community services that may be utilised by an older person living in Australia. Method A comprehensive search of Medline, Embase, CINAHL, Google Scholar and Google was undertaken. Specialised economic databases were also reviewed. In addition Australian Government Department websites were inspected. The search identified the cost of specified allied health services including: physiotherapy, occupational therapy, dietetics, podiatry, counselling and home nursing. The range of community services included: personal care, meals on wheels, transport costs and domestic services. Where the information was not available, direct contact with service providers was made. Results The number of eligible studies included in the qualitative synthesis was fourty-nine. Calculated hourly rates for Australian allied health services were adjusted to be in equivalent currency and were as follows as follows: physiotherapy $157.75, occupational therapy $150.77, dietetics $163.11, psychological services $165.77, community nursing $105.76 and podiatry $129.72. Conclusions Utilisation of the Medicare Benefits Scheduled fee as a broad indicator of the costs of services, may lead to underestimation of the real costs of services and therefore to inaccuracies in economic evaluation. PMID:23421756

  16. The use of artificial neural networks for residential buildings conceptual cost estimation

    NASA Astrophysics Data System (ADS)

    Juszczyk, Michał

    2013-10-01

    Accurate cost estimation in the early phase of the building's design process is of key importance for a project's success. Both underestimation and overestimation may lead to projects failure in terms of costs. The paper presents synthetically some research results on the use of neural networks for conceptual cost estimation of residential buildings. In the course of the research the author focused on regression models binding together the basic information about residential buildings available in the early stage of design and construction cost. Application of different neural networks types was analysed (multilayer perceptron, multilayer perceptron with data compression based on principal component analysis and radial basis function networks). Due to the research results, multilayer perceptron networks proved to be the best neural network type for the problem solution. The research results indicate that a neural approach may be an interesting alternative for the traditional methods of conceptual cost estimation in construction projects.

  17. A low-cost inertial smoothing system for landing approach guidance

    NASA Technical Reports Server (NTRS)

    Niessen, F. R.

    1973-01-01

    Accurate position and velocity information with low noise content for instrument approaches and landings is required for both control and display applications. In a current VTOL automatic instrument approach and landing research program, radar-derived landing guidance position reference signals, which are noisy, have been mixed with acceleration information derived from low-cost onboard sensors to provide high-quality position and velocity information. An in-flight comparison of signal quality and accuracy has shown good agreement between the low-cost inertial smoothing system and an aided inertial navigation system. Furthermore, the low-cost inertial smoothing system has been proven to be satisfactory in control and display system applications for both automatic and pilot-in-the-loop instrument approaches and landings.

  18. Costs and benefits

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Two models of cost benefit analysis are illustrated and the application of these models to assessing the economic scope of space applications programs was discussed. Four major areas cited as improvable through space derived information - food supply and distribution, energy sources, mineral reserves, and communication and navigation were - discussed. Specific illustrations are given for agriculture and maritime traffic.

  19. 32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false DD Form 2086-1, âRecord of Freedom of... Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form...

  20. 32 CFR Appendix D to Part 286 - DD Form 2086-1, “Record of Freedom of Information (FOI) Processing Cost for Technical Data”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false DD Form 2086-1, âRecord of Freedom of... Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT PROGRAM REGULATION Pt. 286, App. D Appendix D to Part 286—DD Form...

  1. Accurate Development of Thermal Neutron Scattering Cross Section Libraries

    SciTech Connect

    Hawari, Ayman; Dunn, Michael

    2014-06-10

    The objective of this project is to develop a holistic (fundamental and accurate) approach for generating thermal neutron scattering cross section libraries for a collection of important enutron moderators and reflectors. The primary components of this approach are the physcial accuracy and completeness of the generated data libraries. Consequently, for the first time, thermal neutron scattering cross section data libraries will be generated that are based on accurate theoretical models, that are carefully benchmarked against experimental and computational data, and that contain complete covariance information that can be used in propagating the data uncertainties through the various components of the nuclear design and execution process. To achieve this objective, computational and experimental investigations will be performed on a carefully selected subset of materials that play a key role in all stages of the nuclear fuel cycle.

  2. Light Field Imaging Based Accurate Image Specular Highlight Removal

    PubMed Central

    Wang, Haoqian; Xu, Chenxue; Wang, Xingzheng; Zhang, Yongbing; Peng, Bo

    2016-01-01

    Specular reflection removal is indispensable to many computer vision tasks. However, most existing methods fail or degrade in complex real scenarios for their individual drawbacks. Benefiting from the light field imaging technology, this paper proposes a novel and accurate approach to remove specularity and improve image quality. We first capture images with specularity by the light field camera (Lytro ILLUM). After accurately estimating the image depth, a simple and concise threshold strategy is adopted to cluster the specular pixels into “unsaturated” and “saturated” category. Finally, a color variance analysis of multiple views and a local color refinement are individually conducted on the two categories to recover diffuse color information. Experimental evaluation by comparison with existed methods based on our light field dataset together with Stanford light field archive verifies the effectiveness of our proposed algorithm. PMID:27253083

  3. Onboard Autonomous Corrections for Accurate IRF Pointing.

    NASA Astrophysics Data System (ADS)

    Jorgensen, J. L.; Betto, M.; Denver, T.

    2002-05-01

    Over the past decade, the Noise Equivalent Angle (NEA) of onboard attitude reference instruments, has decreased from tens-of-arcseconds to the sub-arcsecond level. This improved performance is partly due to improved sensor-technology with enhanced signal to noise ratios, partly due to improved processing electronics which allows for more sophisticated and faster signal processing. However, the main reason for the increased precision, is the application of onboard autonomy, which apart from simple outlier rejection also allows for removal of "false positive" answers, and other "unexpected" noise sources, that otherwise would degrade the quality of the measurements (e.g. discrimination between signals caused by starlight and ionizing radiation). The utilization of autonomous signal processing has also provided the means for another onboard processing step, namely the autonomous recovery from lost in space, where the attitude instrument without a priori knowledge derive the absolute attitude, i.e. in IRF coordinates, within fractions of a second. Combined with precise orbital state or position data, the absolute attitude information opens for multiple ways to improve the mission performance, either by reducing operations costs, by increasing pointing accuracy, by reducing mission expendables, or by providing backup decision information in case of anomalies. The Advanced Stellar Compass's (ASC) is a miniature, high accuracy, attitude instrument which features fully autonomous operations. The autonomy encompass all direct steps from automatic health checkout at power-on, over fully automatic SEU and SEL handling and proton induced sparkle removal, to recovery from "lost in space", and optical disturbance detection and handling. But apart from these more obvious autonomy functions, the ASC also features functions to handle and remove the aforementioned residuals. These functions encompass diverse operators such as a full orbital state vector model with automatic cloud

  4. Application of activity-based costing (ABC) for a Peruvian NGO healthcare provider.

    PubMed

    Waters, H; Abdallah, H; Santillán, D

    2001-01-01

    This article describes the application of activity-based costing (ABC) to calculate the unit costs of the services for a health care provider in Peru. While traditional costing allocates overhead and indirect costs in proportion to production volume or to direct costs, ABC assigns costs through activities within an organization. ABC uses personnel interviews to determine principal activities and the distribution of individual's time among these activities. Indirect costs are linked to services through time allocation and other tracing methods, and the result is a more accurate estimate of unit costs. The study concludes that applying ABC in a developing country setting is feasible, yielding results that are directly applicable to pricing and management. ABC determines costs for individual clinics, departments and services according to the activities that originate these costs, showing where an organization spends its money. With this information, it is possible to identify services that are generating extra revenue and those operating at a loss, and to calculate cross subsidies across services. ABC also highlights areas in the health care process where efficiency improvements are possible. Conclusions about the ultimate impact of the methodology are not drawn here, since the study was not repeated and changes in utilization patterns and the addition of new clinics affected applicability of the results. A potential constraint to implementing ABC is the availability and organization of cost information. Applying ABC efficiently requires information to be readily available, by cost category and department, since the greatest benefits of ABC come from frequent, systematic application of the methodology in order to monitor efficiency and provide feedback for management. The article concludes with a discussion of the potential applications of ABC in the health sector in developing countries. PMID:11326572

  5. The Business Case for Payer Support of a Community-Based Health Information Exchange: A Humana Pilot Evaluating Its Effectiveness in Cost Control for Plan Members Seeking Emergency Department Care

    PubMed Central

    Tzeel, Albert; Lawnicki, Victor; Pemble, Kim R.

    2011-01-01

    Background As emergency department utilization continues to increase, health plans must limit their cost exposure, which may be driven by duplicate testing and a lack of medical history at the point of care. Based on previous studies, health information exchanges (HIEs) can potentially provide health plans with the ability to address this need. Objective To assess the effectiveness of a community-based HIE in controlling plan costs arising from emergency department care for a health plan's members. Albert Tzeel Methods The study design was observational, with an eligible population (N = 1482) of fully insured plan members who sought emergency department care on at least 2 occasions during the study period, from December 2008 through March 2010. Cost and utilization data, obtained from member claims, were matched to a list of persons utilizing the emergency department where HIE querying could have occurred. Eligible members underwent propensity score matching to create a test group (N = 326) in which the HIE database was queried in all emergency department visits, and a control group (N = 325) in which the HIE database was not queried in any emergency department visit. Results Post–propensity matching analysis showed that the test group achieved an average savings of $29 per emergency department visit compared with the control group. Decreased utilization of imaging procedures and diagnostic tests drove this cost-savings. Conclusions When clinicians utilize HIE in the care of patients who present to the emergency department, the costs borne by a health plan providing coverage for these patients decrease. Although many factors can play a role in this finding, it is likely that HIEs obviate unnecessary service utilization through provision of historical medical information regarding specific patients at the point of care. PMID:25126351

  6. Efficient Research Design: Using Value-of-Information Analysis to Estimate the Optimal Mix of Top-down and Bottom-up Costing Approaches in an Economic Evaluation alongside a Clinical Trial.

    PubMed

    Wilson, Edward C F; Mugford, Miranda; Barton, Garry; Shepstone, Lee

    2016-04-01

    In designing economic evaluations alongside clinical trials, analysts are frequently faced with alternative methods of collecting the same data, the extremes being top-down ("gross costing") and bottom-up ("micro-costing") approaches. A priori, bottom-up approaches may be considered superior to top-down approaches but are also more expensive to collect and analyze. In this article, we use value-of-information analysis to estimate the efficient mix of observations on each method in a proposed clinical trial. By assigning a prior bivariate distribution to the 2 data collection processes, the predicted posterior (i.e., preposterior) mean and variance of the superior process can be calculated from proposed samples using either process. This is then used to calculate the preposterior mean and variance of incremental net benefit and hence the expected net gain of sampling. We apply this method to a previously collected data set to estimate the value of conducting a further trial and identifying the optimal mix of observations on drug costs at 2 levels: by individual item (process A) and by drug class (process B). We find that substituting a number of observations on process A for process B leads to a modest £ 35,000 increase in expected net gain of sampling. Drivers of the results are the correlation between the 2 processes and their relative cost. This method has potential use following a pilot study to inform efficient data collection approaches for a subsequent full-scale trial. It provides a formal quantitative approach to inform trialists whether it is efficient to collect resource use data on all patients in a trial or on a subset of patients only or to collect limited data on most and detailed data on a subset. PMID:26762649

  7. A model for the cost of doing a cost estimate

    NASA Technical Reports Server (NTRS)

    Remer, D. S.; Buchanan, H. R.

    1992-01-01

    A model for estimating the cost required to do a cost estimate for Deep Space Network (DSN) projects that range from $0.1 to $100 million is presented. The cost of the cost estimate in thousands of dollars, C(sub E), is found to be approximately given by C(sub E) = K((C(sub p))(sup 0.35)) where C(sub p) is the cost of the project being estimated in millions of dollars and K is a constant depending on the accuracy of the estimate. For an order-of-magnitude estimate, K = 24; for a budget estimate, K = 60; and for a definitive estimate, K = 115. That is, for a specific project, the cost of doing a budget estimate is about 2.5 times as much as that for an order-of-magnitude estimate, and a definitive estimate costs about twice as much as a budget estimate. Use of this model should help provide the level of resources required for doing cost estimates and, as a result, provide insights towards more accurate estimates with less potential for cost overruns.

  8. Selected Tether Applications Cost Model

    NASA Technical Reports Server (NTRS)

    Keeley, Michael G.

    1988-01-01

    Diverse cost-estimating techniques and data combined into single program. Selected Tether Applications Cost Model (STACOM 1.0) is interactive accounting software tool providing means for combining several independent cost-estimating programs into fully-integrated mathematical model capable of assessing costs, analyzing benefits, providing file-handling utilities, and putting out information in text and graphical forms to screen, printer, or plotter. Program based on Lotus 1-2-3, version 2.0. Developed to provide clear, concise traceability and visibility into methodology and rationale for estimating costs and benefits of operations of Space Station tether deployer system.

  9. Solar power satellite cost estimate

    NASA Technical Reports Server (NTRS)

    Harron, R. J.; Wadle, R. C.

    1981-01-01

    The solar power configuration costed is the 5 GW silicon solar cell reference system. The subsystems identified by work breakdown structure elements to the lowest level for which cost information was generated. This breakdown divides into five sections: the satellite, construction, transportation, the ground receiving station and maintenance. For each work breakdown structure element, a definition, design description and cost estimate were included. An effort was made to include for each element a reference that more thoroughly describes the element and the method of costing used. All costs are in 1977 dollars.

  10. Efficient and Accurate Indoor Localization Using Landmark Graphs

    NASA Astrophysics Data System (ADS)

    Gu, F.; Kealy, A.; Khoshelham, K.; Shang, J.

    2016-06-01

    Indoor localization is important for a variety of applications such as location-based services, mobile social networks, and emergency response. Fusing spatial information is an effective way to achieve accurate indoor localization with little or with no need for extra hardware. However, existing indoor localization methods that make use of spatial information are either too computationally expensive or too sensitive to the completeness of landmark detection. In this paper, we solve this problem by using the proposed landmark graph. The landmark graph is a directed graph where nodes are landmarks (e.g., doors, staircases, and turns) and edges are accessible paths with heading information. We compared the proposed method with two common Dead Reckoning (DR)-based methods (namely, Compass + Accelerometer + Landmarks and Gyroscope + Accelerometer + Landmarks) by a series of experiments. Experimental results show that the proposed method can achieve 73% accuracy with a positioning error less than 2.5 meters, which outperforms the other two DR-based methods.

  11. Accurate object tracking system by integrating texture and depth cues

    NASA Astrophysics Data System (ADS)

    Chen, Ju-Chin; Lin, Yu-Hang

    2016-03-01

    A robust object tracking system that is invariant to object appearance variations and background clutter is proposed. Multiple instance learning with a boosting algorithm is applied to select discriminant texture information between the object and background data. Additionally, depth information, which is important to distinguish the object from a complicated background, is integrated. We propose two depth-based models that can compensate texture information to cope with both appearance variants and background clutter. Moreover, in order to reduce the risk of drifting problem increased for the textureless depth templates, an update mechanism is proposed to select more precise tracking results to avoid incorrect model updates. In the experiments, the robustness of the proposed system is evaluated and quantitative results are provided for performance analysis. Experimental results show that the proposed system can provide the best success rate and has more accurate tracking results than other well-known algorithms.

  12. Feedback about More Accurate versus Less Accurate Trials: Differential Effects on Self-Confidence and Activation

    ERIC Educational Resources Information Center

    Badami, Rokhsareh; VaezMousavi, Mohammad; Wulf, Gabriele; Namazizadeh, Mahdi

    2012-01-01

    One purpose of the present study was to examine whether self-confidence or anxiety would be differentially affected by feedback from more accurate rather than less accurate trials. The second purpose was to determine whether arousal variations (activation) would predict performance. On Day 1, participants performed a golf putting task under one of…

  13. Cost-Effectiveness of a School-based Emotional Health Screening Program

    PubMed Central

    Kuo, Elena; Stoep, Ann Vander; McCauley, Elizabeth; Kernic, Mary A.

    2009-01-01

    Background School-based screening for health conditions can help extend the reach of health services to underserved populations. Screening for mental health conditions is growing in acceptability; however, evidence of cost-effectiveness is lacking. This study assesses costs and effectiveness associated with the Developmental Pathways Screening Program, in which students undergo universal classroom emotional health screening, and positive screens are provided on-site clinical evaluation and referral. Methods Costs are enumerated for screening and clinical evaluation in terms of labor and overhead and summarized as cost per enrolled student, per positive screen, and per referral. Cost-effectiveness is summarized as cost per student successfully linked to services. School demographics are used to generate a predictive formula for estimating the proportion of students likely to screen positive in a particular school, which can be used to estimate program cost. Results Screening costs ranged from $8.88 to 13.64 per enrolled student, depending on the prevalence of positive screens in a school. Of students who were referred for services, 72% were linked to supportive services within 6 weeks. Cost-effectiveness was estimated to be $416.90 per successful linkage when 5% of students screened positive, and $106.09 when 20% screened positive. A formula for estimating the proportion of students screening positive proved accurate to within 5%. Conclusion Information concerning costs and effectiveness of school-based emotional health screening programs can guide school districts in making decisions concerning resource allocation. PMID:19432868

  14. Medicaid: Determining Cost-Effectiveness of Home and Community-Based Services. Report to the Administrator, Health Care Financing Administration, Department of Health and Human Services.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    To examine alternatives to nursing home care, states have been testing home and community-based services under the Medicaid program. Information on the operations of the state projects will be vital to designing cost-effective alternative services in the future. The General Accounting Office (GAO) reviewed state reports to see if accurate,…

  15. Cost Control

    ERIC Educational Resources Information Center

    Foreman, Phillip

    2009-01-01

    Education administrators involved in construction initiatives unanimously agree that when it comes to change orders, less is more. Change orders have a negative rippling effect of driving up building costs and producing expensive project delays that often interfere with school operations and schedules. Some change orders are initiated by schools…

  16. Feedback about more accurate versus less accurate trials: differential effects on self-confidence and activation.

    PubMed

    Badami, Rokhsareh; VaezMousavi, Mohammad; Wulf, Gabriele; Namazizadeh, Mahdi

    2012-06-01

    One purpose of the present study was to examine whether self-confidence or anxiety would be differentially affected byfeedback from more accurate rather than less accurate trials. The second purpose was to determine whether arousal variations (activation) would predict performance. On day 1, participants performed a golf putting task under one of two conditions: one group received feedback on the most accurate trials, whereas another group received feedback on the least accurate trials. On day 2, participants completed an anxiety questionnaire and performed a retention test. Shin conductance level, as a measure of arousal, was determined. The results indicated that feedback about more accurate trials resulted in more effective learning as well as increased self-confidence. Also, activation was a predictor of performance. PMID:22808705

  17. New model accurately predicts reformate composition

    SciTech Connect

    Ancheyta-Juarez, J.; Aguilar-Rodriguez, E. )

    1994-01-31

    Although naphtha reforming is a well-known process, the evolution of catalyst formulation, as well as new trends in gasoline specifications, have led to rapid evolution of the process, including: reactor design, regeneration mode, and operating conditions. Mathematical modeling of the reforming process is an increasingly important tool. It is fundamental to the proper design of new reactors and revamp of existing ones. Modeling can be used to optimize operating conditions, analyze the effects of process variables, and enhance unit performance. Instituto Mexicano del Petroleo has developed a model of the catalytic reforming process that accurately predicts reformate composition at the higher-severity conditions at which new reformers are being designed. The new AA model is more accurate than previous proposals because it takes into account the effects of temperature and pressure on the rate constants of each chemical reaction.

  18. Accurate colorimetric feedback for RGB LED clusters

    NASA Astrophysics Data System (ADS)

    Man, Kwong; Ashdown, Ian

    2006-08-01

    We present an empirical model of LED emission spectra that is applicable to both InGaN and AlInGaP high-flux LEDs, and which accurately predicts their relative spectral power distributions over a wide range of LED junction temperatures. We further demonstrate with laboratory measurements that changes in LED spectral power distribution with temperature can be accurately predicted with first- or second-order equations. This provides the basis for a real-time colorimetric feedback system for RGB LED clusters that can maintain the chromaticity of white light at constant intensity to within +/-0.003 Δuv over a range of 45 degrees Celsius, and to within 0.01 Δuv when dimmed over an intensity range of 10:1.

  19. Accurate guitar tuning by cochlear implant musicians.

    PubMed

    Lu, Thomas; Huang, Juan; Zeng, Fan-Gang

    2014-01-01

    Modern cochlear implant (CI) users understand speech but find difficulty in music appreciation due to poor pitch perception. Still, some deaf musicians continue to perform with their CI. Here we show unexpected results that CI musicians can reliably tune a guitar by CI alone and, under controlled conditions, match simultaneously presented tones to <0.5 Hz. One subject had normal contralateral hearing and produced more accurate tuning with CI than his normal ear. To understand these counterintuitive findings, we presented tones sequentially and found that tuning error was larger at ∼ 30 Hz for both subjects. A third subject, a non-musician CI user with normal contralateral hearing, showed similar trends in performance between CI and normal hearing ears but with less precision. This difference, along with electric analysis, showed that accurate tuning was achieved by listening to beats rather than discriminating pitch, effectively turning a spectral task into a temporal discrimination task. PMID:24651081

  20. Two highly accurate methods for pitch calibration

    NASA Astrophysics Data System (ADS)

    Kniel, K.; Härtig, F.; Osawa, S.; Sato, O.

    2009-11-01

    Among profiles, helix and tooth thickness pitch is one of the most important parameters of an involute gear measurement evaluation. In principle, coordinate measuring machines (CMM) and CNC-controlled gear measuring machines as a variant of a CMM are suited for these kinds of gear measurements. Now the Japan National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) and the German national metrology institute the Physikalisch-Technische Bundesanstalt (PTB) have each developed independently highly accurate pitch calibration methods applicable to CMM or gear measuring machines. Both calibration methods are based on the so-called closure technique which allows the separation of the systematic errors of the measurement device and the errors of the gear. For the verification of both calibration methods, NMIJ/AIST and PTB performed measurements on a specially designed pitch artifact. The comparison of the results shows that both methods can be used for highly accurate calibrations of pitch standards.

  1. Accurate Guitar Tuning by Cochlear Implant Musicians

    PubMed Central

    Lu, Thomas; Huang, Juan; Zeng, Fan-Gang

    2014-01-01

    Modern cochlear implant (CI) users understand speech but find difficulty in music appreciation due to poor pitch perception. Still, some deaf musicians continue to perform with their CI. Here we show unexpected results that CI musicians can reliably tune a guitar by CI alone and, under controlled conditions, match simultaneously presented tones to <0.5 Hz. One subject had normal contralateral hearing and produced more accurate tuning with CI than his normal ear. To understand these counterintuitive findings, we presented tones sequentially and found that tuning error was larger at ∼30 Hz for both subjects. A third subject, a non-musician CI user with normal contralateral hearing, showed similar trends in performance between CI and normal hearing ears but with less precision. This difference, along with electric analysis, showed that accurate tuning was achieved by listening to beats rather than discriminating pitch, effectively turning a spectral task into a temporal discrimination task. PMID:24651081

  2. An accurate registration technique for distorted images

    NASA Technical Reports Server (NTRS)

    Delapena, Michele; Shaw, Richard A.; Linde, Peter; Dravins, Dainis

    1990-01-01

    Accurate registration of International Ultraviolet Explorer (IUE) images is crucial because the variability of the geometrical distortions that are introduced by the SEC-Vidicon cameras ensures that raw science images are never perfectly aligned with the Intensity Transfer Functions (ITFs) (i.e., graded floodlamp exposures that are used to linearize and normalize the camera response). A technique for precisely registering IUE images which uses a cross correlation of the fixed pattern that exists in all raw IUE images is described.

  3. Accurate maser positions for MALT-45

    NASA Astrophysics Data System (ADS)

    Jordan, Christopher; Bains, Indra; Voronkov, Maxim; Lo, Nadia; Jones, Paul; Muller, Erik; Cunningham, Maria; Burton, Michael; Brooks, Kate; Green, James; Fuller, Gary; Barnes, Peter; Ellingsen, Simon; Urquhart, James; Morgan, Larry; Rowell, Gavin; Walsh, Andrew; Loenen, Edo; Baan, Willem; Hill, Tracey; Purcell, Cormac; Breen, Shari; Peretto, Nicolas; Jackson, James; Lowe, Vicki; Longmore, Steven

    2013-10-01

    MALT-45 is an untargeted survey, mapping the Galactic plane in CS (1-0), Class I methanol masers, SiO masers and thermal emission, and high frequency continuum emission. After obtaining images from the survey, a number of masers were detected, but without accurate positions. This project seeks to resolve each maser and its environment, with the ultimate goal of placing the Class I methanol maser into a timeline of high mass star formation.

  4. Lifetime costs of cerebral palsy.

    PubMed

    Kruse, Marie; Michelsen, Susan Ishøy; Flachs, Esben Meulengracht; Brønnum-Hansen, Henrik; Madsen, Mette; Uldall, Peter

    2009-08-01

    This study quantified the lifetime costs of cerebral palsy (CP) in a register-based setting. It was the first study outside the US to assess the lifetime costs of CP. The lifetime costs attributable to CP were divided into three categories: health care costs, productivity costs, and social costs. The population analysed was retrieved from the Danish Cerebral Palsy Register, which covers the eastern part of the country and has registered about half of the Danish population of individuals with CP since 1950. For this study we analysed 2367 individuals with CP, who were born in 1930 to 2000 and were alive in 2000. The prevalence of CP in eastern Denmark was approximately 1.7 per 1000. Information on productivity and the use of health care was retrieved from registers. The lifetime cost of CP was about 860,000 euro for men and about 800,000 euro for women. The largest component was social care costs, particularly during childhood. A sensitivity analysis found that alterations in social care costs had a small effect, whereas lowering the discount rate from 5 to 3 per cent markedly increased total lifetime costs. Discounting decreases the value of costs in the future compared with the present. The high social care costs and productivity costs associated with CP point to a potential gain from labour market interventions that benefit individuals with CP. PMID:19416329

  5. Accurate Molecular Polarizabilities Based on Continuum Electrostatics

    PubMed Central

    Truchon, Jean-François; Nicholls, Anthony; Iftimie, Radu I.; Roux, Benoît; Bayly, Christopher I.

    2013-01-01

    A novel approach for representing the intramolecular polarizability as a continuum dielectric is introduced to account for molecular electronic polarization. It is shown, using a finite-difference solution to the Poisson equation, that the Electronic Polarization from Internal Continuum (EPIC) model yields accurate gas-phase molecular polarizability tensors for a test set of 98 challenging molecules composed of heteroaromatics, alkanes and diatomics. The electronic polarization originates from a high intramolecular dielectric that produces polarizabilities consistent with B3LYP/aug-cc-pVTZ and experimental values when surrounded by vacuum dielectric. In contrast to other approaches to model electronic polarization, this simple model avoids the polarizability catastrophe and accurately calculates molecular anisotropy with the use of very few fitted parameters and without resorting to auxiliary sites or anisotropic atomic centers. On average, the unsigned error in the average polarizability and anisotropy compared to B3LYP are 2% and 5%, respectively. The correlation between the polarizability components from B3LYP and this approach lead to a R2 of 0.990 and a slope of 0.999. Even the F2 anisotropy, shown to be a difficult case for existing polarizability models, can be reproduced within 2% error. In addition to providing new parameters for a rapid method directly applicable to the calculation of polarizabilities, this work extends the widely used Poisson equation to areas where accurate molecular polarizabilities matter. PMID:23646034

  6. Costing Children's Speech, Language and Communication Interventions

    ERIC Educational Resources Information Center

    Beecham, Jennifer; Law, James; Zeng, Biao; Lindsay, Geoff

    2012-01-01

    Background: There are few economic evaluations of speech and language interventions. Such work requires underpinning by an accurate estimate of the costs of the intervention. This study seeks to address some of the complexities of this task by applying existing approaches of cost estimation to interventions described in published effectiveness…

  7. High Frequency QRS ECG Accurately Detects Cardiomyopathy

    NASA Technical Reports Server (NTRS)

    Schlegel, Todd T.; Arenare, Brian; Poulin, Gregory; Moser, Daniel R.; Delgado, Reynolds

    2005-01-01

    High frequency (HF, 150-250 Hz) analysis over the entire QRS interval of the ECG is more sensitive than conventional ECG for detecting myocardial ischemia. However, the accuracy of HF QRS ECG for detecting cardiomyopathy is unknown. We obtained simultaneous resting conventional and HF QRS 12-lead ECGs in 66 patients with cardiomyopathy (EF = 23.2 plus or minus 6.l%, mean plus or minus SD) and in 66 age- and gender-matched healthy controls using PC-based ECG software recently developed at NASA. The single most accurate ECG parameter for detecting cardiomyopathy was an HF QRS morphological score that takes into consideration the total number and severity of reduced amplitude zones (RAZs) present plus the clustering of RAZs together in contiguous leads. This RAZ score had an area under the receiver operator curve (ROC) of 0.91, and was 88% sensitive, 82% specific and 85% accurate for identifying cardiomyopathy at optimum score cut-off of 140 points. Although conventional ECG parameters such as the QRS and QTc intervals were also significantly longer in patients than controls (P less than 0.001, BBBs excluded), these conventional parameters were less accurate (area under the ROC = 0.77 and 0.77, respectively) than HF QRS morphological parameters for identifying underlying cardiomyopathy. The total amplitude of the HF QRS complexes, as measured by summed root mean square voltages (RMSVs), also differed between patients and controls (33.8 plus or minus 11.5 vs. 41.5 plus or minus 13.6 mV, respectively, P less than 0.003), but this parameter was even less accurate in distinguishing the two groups (area under ROC = 0.67) than the HF QRS morphologic and conventional ECG parameters. Diagnostic accuracy was optimal (86%) when the RAZ score from the HF QRS ECG and the QTc interval from the conventional ECG were used simultaneously with cut-offs of greater than or equal to 40 points and greater than or equal to 445 ms, respectively. In conclusion 12-lead HF QRS ECG employing

  8. Standard cost elements for technology programs

    NASA Technical Reports Server (NTRS)

    Christensen, Carisa B.; Wagenfuehrer, Carl

    1992-01-01

    The suitable structure for an effective and accurate cost estimate for general purposes is discussed in the context of a NASA technology program. Cost elements are defined for research, management, and facility-construction portions of technology programs. Attention is given to the mechanisms for insuring the viability of spending programs, and the need for program managers is established for effecting timely fund disbursement. Formal, structures, and intuitive techniques are discussed for cost-estimate development, and cost-estimate defensibility can be improved with increased documentation. NASA policies for cash management are examined to demonstrate the importance of the ability to obligate funds and the ability to cost contracted funds. The NASA approach to consistent cost justification is set forth with a list of standard cost-element definitions. The cost elements reflect the three primary concerns of cost estimates: the identification of major assumptions, the specification of secondary analytic assumptions, and the status of program factors.

  9. Estimating archiving costs for engineering records

    SciTech Connect

    Stutz, R.A.; Lamartine, B.C.

    1997-02-01

    Information technology has completely changed the concept of record keeping for engineering projects -- the advent of digital records was a momentous discovery, as significant as the invention of the printing press. Digital records allowed huge amounts of information to be stored in a very small space and to be examined quickly. However, digital documents are much more vulnerable to the passage of time than printed documents because the media on which they are stored are easily affected by physical phenomena, such as magnetic fields, oxidation, material decay, and by various environmental factors that may erase the information. Even more important, digital information becomes obsolete because, even if future generations may be able to read it, they may not necessarily be able to interpret it. Engineering projects of all sizes are becoming more dependent on digital records. These records are created on computers used in design, estimating, construction management, and construction. The necessity for the accurate and accessible storage of these documents, generated by computer software systems, is increasing for a number of reasons including legal and environment issues. This paper will discuss media life considerations and life cycle costs associated with several methods of storing engineering records.

  10. Accurate documentation in cultural heritage by merging TLS and high-resolution photogrammetric data

    NASA Astrophysics Data System (ADS)

    Grussenmeyer, Pierre; Alby, Emmanuel; Assali, Pierre; Poitevin, Valentin; Hullo, Jean-François; Smigiel, Eddie

    2011-07-01

    Several recording techniques are used together in Cultural Heritage Documentation projects. The main purpose of the documentation and conservation works is usually to generate geometric and photorealistic 3D models for both accurate reconstruction and visualization purposes. The recording approach discussed in this paper is based on the combination of photogrammetric dense matching and Terrestrial Laser Scanning (TLS) techniques. Both techniques have pros and cons, and criteria as geometry, texture, accuracy, resolution, recording and processing time are often compared. TLS techniques (time of flight or phase shift systems) are often used for the recording of large and complex objects or sites. Point cloud generation from images by dense stereo or multi-image matching can be used as an alternative or a complementary method to TLS. Compared to TLS, the photogrammetric solution is a low cost one as the acquisition system is limited to a digital camera and a few accessories only. Indeed, the stereo matching process offers a cheap, flexible and accurate solution to get 3D point clouds and textured models. The calibration of the camera allows the processing of distortion free images, accurate orientation of the images, and matching at the subpixel level. The main advantage of this photogrammetric methodology is to get at the same time a point cloud (the resolution depends on the size of the pixel on the object), and therefore an accurate meshed object with its texture. After the matching and processing steps, we can use the resulting data in much the same way as a TLS point cloud, but with really better raster information for textures. The paper will address the automation of recording and processing steps, the assessment of the results, and the deliverables (e.g. PDF-3D files). Visualization aspects of the final 3D models are presented. Two case studies with merged photogrammetric and TLS data are finally presented: - The Gallo-roman Theatre of Mandeure, France); - The

  11. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs, and... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Allowable costs. 85.41 Section 85.41... Use/Acceptance of Funds § 85.41 Allowable costs. (a) Allowable grant costs are limited to those...

  12. 38 CFR 17.259 - Direct costs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Direct costs. 17.259... Exchange of Information § 17.259 Direct costs. Direct costs to which grant funds may be applied may include in proportion to time and effort spent, but are not limited to, fees and costs directly paid...

  13. Activity-based costing and its application in a Turkish university hospital.

    PubMed

    Yereli, Ayşe Necef

    2009-03-01

    Resource management in hospitals is of increasing importance in today's global economy. Traditional accounting systems have become inadequate for managing hospital resources and accurately determining service costs. Conversely, the activity-based costing approach to hospital accounting is an effective cost management model that determines costs and evaluates financial performance across departments. Obtaining costs that are more accurate can enable hospitals to analyze and interpret costing decisions and make more accurate budgeting decisions. Traditional and activity-based costing approaches were compared using a cost analysis of gall bladder surgeries in the general surgery department of one university hospital in Manisa, Turkey. PMID:19269382

  14. Accurate multiplex gene synthesis from programmable DNA microchips

    NASA Astrophysics Data System (ADS)

    Tian, Jingdong; Gong, Hui; Sheng, Nijing; Zhou, Xiaochuan; Gulari, Erdogan; Gao, Xiaolian; Church, George

    2004-12-01

    Testing the many hypotheses from genomics and systems biology experiments demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of `construction' oligonucleotides and tagged complementary `selection' oligonucleotides are synthesized on photo-programmable microfluidic chips, released, amplified and selected by hybridization to reduce synthesis errors ninefold. A one-step polymerase assembly multiplexing reaction assembles these into multiple genes. This technology enabled us to synthesize all 21 genes that encode the proteins of the Escherichia coli 30S ribosomal subunit, and to optimize their translation efficiency in vitro through alteration of codon bias. This is a significant step towards the synthesis of ribosomes in vitro and should have utility for synthetic biology in general.

  15. CLOMP: Accurately Characterizing OpenMP Application Overheads

    SciTech Connect

    Bronevetsky, G; Gyllenhaal, J; de Supinski, B

    2008-02-11

    Despite its ease of use, OpenMP has failed to gain widespread use on large scale systems, largely due to its failure to deliver sufficient performance. Our experience indicates that the cost of initiating OpenMP regions is simply too high for the desired OpenMP usage scenario of many applications. In this paper, we introduce CLOMP, a new benchmark to characterize this aspect of OpenMP implementations accurately. CLOMP complements the existing EPCC benchmark suite to provide simple, easy to understand measurements of OpenMP overheads in the context of application usage scenarios. Our results for several OpenMP implementations demonstrate that CLOMP identifies the amount of work required to compensate for the overheads observed with EPCC. Further, we show that CLOMP also captures limitations for OpenMP parallelization on NUMA systems.

  16. CARETS: A prototype regional environmental information system. Volume 6: Cost, accuracy and consistency comparisons of land use maps made from high-altitude aircraft photography and ERTS imagery

    NASA Technical Reports Server (NTRS)

    Alexander, R. H. (Principal Investigator); Fitzpatrick, K. A.

    1975-01-01

    The author has identified the following significant results. Level 2 land use maps produced at three scales (1:24,000, 1:100,000, and 1:250,000) from high altitude photography were compared with each other and with point data obtained in the field. The same procedures were employed to determine the accuracy of the Level 1 land use maps produced at 1:250,000 from high altitude photography and color composite ERTS imagery. Accuracy of the Level 2 maps was 84.9 percent at 1:24,000, 77.4 percent at 1:100,000 and 73.0 percent at 1:250,000. Accuracy of the Level 1 1:250,000 maps was 76.5 percent for aerial photographs and 69.5 percent for ERTS imagery. The cost of Level 2 land use mapping at 1:24,000 was found to be high ($11.93 per sq km). The cost of mapping at 1:100,000 ($1.75) was about two times as expensive as mapping at 1:250,000 ($.88), and the accuracy increased by only 4.4 percent.

  17. Accurate thermoelastic tensor and acoustic velocities of NaCl

    NASA Astrophysics Data System (ADS)

    Marcondes, Michel L.; Shukla, Gaurav; da Silveira, Pedro; Wentzcovitch, Renata M.

    2015-12-01

    Despite the importance of thermoelastic properties of minerals in geology and geophysics, their measurement at high pressures and temperatures are still challenging. Thus, ab initio calculations are an essential tool for predicting these properties at extreme conditions. Owing to the approximate description of the exchange-correlation energy, approximations used in calculations of vibrational effects, and numerical/methodological approximations, these methods produce systematic deviations. Hybrid schemes combining experimental data and theoretical results have emerged as a way to reconcile available information and offer more reliable predictions at experimentally inaccessible thermodynamics conditions. Here we introduce a method to improve the calculated thermoelastic tensor by using highly accurate thermal equation of state (EoS). The corrective scheme is general, applicable to crystalline solids with any symmetry, and can produce accurate results at conditions where experimental data may not exist. We apply it to rock-salt-type NaCl, a material whose structural properties have been challenging to describe accurately by standard ab initio methods and whose acoustic/seismic properties are important for the gas and oil industry.

  18. Can blind persons accurately assess body size from the voice?

    PubMed

    Pisanski, Katarzyna; Oleszkiewicz, Anna; Sorokowska, Agnieszka

    2016-04-01

    Vocal tract resonances provide reliable information about a speaker's body size that human listeners use for biosocial judgements as well as speech recognition. Although humans can accurately assess men's relative body size from the voice alone, how this ability is acquired remains unknown. In this study, we test the prediction that accurate voice-based size estimation is possible without prior audiovisual experience linking low frequencies to large bodies. Ninety-one healthy congenitally or early blind, late blind and sighted adults (aged 20-65) participated in the study. On the basis of vowel sounds alone, participants assessed the relative body sizes of male pairs of varying heights. Accuracy of voice-based body size assessments significantly exceeded chance and did not differ among participants who were sighted, or congenitally blind or who had lost their sight later in life. Accuracy increased significantly with relative differences in physical height between men, suggesting that both blind and sighted participants used reliable vocal cues to size (i.e. vocal tract resonances). Our findings demonstrate that prior visual experience is not necessary for accurate body size estimation. This capacity, integral to both nonverbal communication and speech perception, may be present at birth or may generalize from broader cross-modal correspondences. PMID:27095264

  19. Accurate thermoelastic tensor and acoustic velocities of NaCl

    SciTech Connect

    Marcondes, Michel L.; Shukla, Gaurav; Silveira, Pedro da; Wentzcovitch, Renata M.

    2015-12-15

    Despite the importance of thermoelastic properties of minerals in geology and geophysics, their measurement at high pressures and temperatures are still challenging. Thus, ab initio calculations are an essential tool for predicting these properties at extreme conditions. Owing to the approximate description of the exchange-correlation energy, approximations used in calculations of vibrational effects, and numerical/methodological approximations, these methods produce systematic deviations. Hybrid schemes combining experimental data and theoretical results have emerged as a way to reconcile available information and offer more reliable predictions at experimentally inaccessible thermodynamics conditions. Here we introduce a method to improve the calculated thermoelastic tensor by using highly accurate thermal equation of state (EoS). The corrective scheme is general, applicable to crystalline solids with any symmetry, and can produce accurate results at conditions where experimental data may not exist. We apply it to rock-salt-type NaCl, a material whose structural properties have been challenging to describe accurately by standard ab initio methods and whose acoustic/seismic properties are important for the gas and oil industry.

  20. Accurate 3D quantification of the bronchial parameters in MDCT

    NASA Astrophysics Data System (ADS)

    Saragaglia, A.; Fetita, C.; Preteux, F.; Brillet, P. Y.; Grenier, P. A.

    2005-08-01

    The assessment of bronchial reactivity and wall remodeling in asthma plays a crucial role in better understanding such a disease and evaluating therapeutic responses. Today, multi-detector computed tomography (MDCT) makes it possible to perform an accurate estimation of bronchial parameters (lumen and wall areas) by allowing a quantitative analysis in a cross-section plane orthogonal to the bronchus axis. This paper provides the tools for such an analysis by developing a 3D investigation method which relies on 3D reconstruction of bronchial lumen and central axis computation. Cross-section images at bronchial locations interactively selected along the central axis are generated at appropriate spatial resolution. An automated approach is then developed for accurately segmenting the inner and outer bronchi contours on the cross-section images. It combines mathematical morphology operators, such as "connection cost", and energy-controlled propagation in order to overcome the difficulties raised by vessel adjacencies and wall irregularities. The segmentation accuracy was validated with respect to a 3D mathematically-modeled phantom of a pair bronchus-vessel which mimics the characteristics of real data in terms of gray-level distribution, caliber and orientation. When applying the developed quantification approach to such a model with calibers ranging from 3 to 10 mm diameter, the lumen area relative errors varied from 3.7% to 0.15%, while the bronchus area was estimated with a relative error less than 5.1%.

  1. Gauging Technology Costs and Benefits

    ERIC Educational Resources Information Center

    Kaestner, Rich

    2007-01-01

    Regardless of the role technology plays in a school district, district personnel should know the costs associated with technology, understand the consequences of technology purchases, and be able to measure the benefits of technology, so they can make more informed decisions. However, determining costs and benefits of current technology or…

  2. Program Tracks Cost Of Travel

    NASA Technical Reports Server (NTRS)

    Mauldin, Lemuel E., III

    1993-01-01

    Travel Forecaster is menu-driven, easy-to-use computer program that plans, forecasts cost, and tracks actual vs. planned cost of business-related travel of division or branch of organization and compiles information into data base to aid travel planner. Ability of program to handle multiple trip entries makes it valuable time-saving device.

  3. Treatment program operations and costs.

    PubMed

    Broome, Kirk M; Knight, Danica K; Joe, George W; Flynn, Patrick M

    2012-03-01

    This study investigates how average costs for an episode of care in outpatient drug-free (ODF) treatment relate to clinical intensity (length of stay and weekly counseling hours) and program structure (e.g., size, staffing), controlling for prices paid and selected clientele measures. Based on cost assessments from a naturalistic sample of 67 programs located across the United States (using the Treatment Cost Analysis Tool), robust regression techniques showed that programs having 10% longer treatment stays had episode costs 7% higher; those having 10% more weekly counseling hours per client had 4% higher episode costs. Other important factors included wages, amount of counselors' time conducting sessions, and serving more clients referred from the criminal justice system. The study provides valuable information on treatment program features that relate to costs. Most importantly, cost differences associated with longer stays or more intensive counseling protocols appear modest and may be justified by improved client outcomes. PMID:22154033

  4. Analysis of Costs and Performance

    ERIC Educational Resources Information Center

    Duchesne, Roderick M.

    1973-01-01

    This article outlines a library management information system concerned with total library costs and performance. The system is essentially an adaptation of well-proven industrial and commercial management accounting techniques to the library context. (24 references) (Author)

  5. Accurately Mapping M31's Microlensing Population

    NASA Astrophysics Data System (ADS)

    Crotts, Arlin

    2004-07-01

    We propose to augment an existing microlensing survey of M31 with source identifications provided by a modest amount of ACS {and WFPC2 parallel} observations to yield an accurate measurement of the masses responsible for microlensing in M31, and presumably much of its dark matter. The main benefit of these data is the determination of the physical {or "einstein"} timescale of each microlensing event, rather than an effective {"FWHM"} timescale, allowing masses to be determined more than twice as accurately as without HST data. The einstein timescale is the ratio of the lensing cross-sectional radius and relative velocities. Velocities are known from kinematics, and the cross-section is directly proportional to the {unknown} lensing mass. We cannot easily measure these quantities without knowing the amplification, hence the baseline magnitude, which requires the resolution of HST to find the source star. This makes a crucial difference because M31 lens m ass determinations can be more accurate than those towards the Magellanic Clouds through our Galaxy's halo {for the same number of microlensing events} due to the better constrained geometry in the M31 microlensing situation. Furthermore, our larger survey, just completed, should yield at least 100 M31 microlensing events, more than any Magellanic survey. A small amount of ACS+WFPC2 imaging will deliver the potential of this large database {about 350 nights}. For the whole survey {and a delta-function mass distribution} the mass error should approach only about 15%, or about 6% error in slope for a power-law distribution. These results will better allow us to pinpoint the lens halo fraction, and the shape of the halo lens spatial distribution, and allow generalization/comparison of the nature of halo dark matter in spiral galaxies. In addition, we will be able to establish the baseline magnitude for about 50, 000 variable stars, as well as measure an unprecedentedly deta iled color-magnitude diagram and luminosity

  6. Accurate measurement of unsteady state fluid temperature

    NASA Astrophysics Data System (ADS)

    Jaremkiewicz, Magdalena

    2016-07-01

    In this paper, two accurate methods for determining the transient fluid temperature were presented. Measurements were conducted for boiling water since its temperature is known. At the beginning the thermometers are at the ambient temperature and next they are immediately immersed into saturated water. The measurements were carried out with two thermometers of different construction but with the same housing outer diameter equal to 15 mm. One of them is a K-type industrial thermometer widely available commercially. The temperature indicated by the thermometer was corrected considering the thermometers as the first or second order inertia devices. The new design of a thermometer was proposed and also used to measure the temperature of boiling water. Its characteristic feature is a cylinder-shaped housing with the sheath thermocouple located in its center. The temperature of the fluid was determined based on measurements taken in the axis of the solid cylindrical element (housing) using the inverse space marching method. Measurements of the transient temperature of the air flowing through the wind tunnel using the same thermometers were also carried out. The proposed measurement technique provides more accurate results compared with measurements using industrial thermometers in conjunction with simple temperature correction using the inertial thermometer model of the first or second order. By comparing the results, it was demonstrated that the new thermometer allows obtaining the fluid temperature much faster and with higher accuracy in comparison to the industrial thermometer. Accurate measurements of the fast changing fluid temperature are possible due to the low inertia thermometer and fast space marching method applied for solving the inverse heat conduction problem.

  7. Accurate upwind methods for the Euler equations

    NASA Technical Reports Server (NTRS)

    Huynh, Hung T.

    1993-01-01

    A new class of piecewise linear methods for the numerical solution of the one-dimensional Euler equations of gas dynamics is presented. These methods are uniformly second-order accurate, and can be considered as extensions of Godunov's scheme. With an appropriate definition of monotonicity preservation for the case of linear convection, it can be shown that they preserve monotonicity. Similar to Van Leer's MUSCL scheme, they consist of two key steps: a reconstruction step followed by an upwind step. For the reconstruction step, a monotonicity constraint that preserves uniform second-order accuracy is introduced. Computational efficiency is enhanced by devising a criterion that detects the 'smooth' part of the data where the constraint is redundant. The concept and coding of the constraint are simplified by the use of the median function. A slope steepening technique, which has no effect at smooth regions and can resolve a contact discontinuity in four cells, is described. As for the upwind step, existing and new methods are applied in a manner slightly different from those in the literature. These methods are derived by approximating the Euler equations via linearization and diagonalization. At a 'smooth' interface, Harten, Lax, and Van Leer's one intermediate state model is employed. A modification for this model that can resolve contact discontinuities is presented. Near a discontinuity, either this modified model or a more accurate one, namely, Roe's flux-difference splitting. is used. The current presentation of Roe's method, via the conceptually simple flux-vector splitting, not only establishes a connection between the two splittings, but also leads to an admissibility correction with no conditional statement, and an efficient approximation to Osher's approximate Riemann solver. These reconstruction and upwind steps result in schemes that are uniformly second-order accurate and economical at smooth regions, and yield high resolution at discontinuities.

  8. Providing Low-Cost Information Technology Access to Rural Communities in Developing Countries: What Works? What Pays? OECD Development Centre Working Paper No. 229 (Formerly Webdoc No. 17)

    ERIC Educational Resources Information Center

    Caspary, Georg; O'Connor, David

    2003-01-01

    Rural areas of the developing world are the last frontier of the information technology revolution. Telephone and internet penetration there remains a small fraction of what it is in the developed world. Limited means of electronic communication with the outside world are just one source of isolation of rural communities and economies from the…

  9. Results of an Experimental Program to Provide Low Cost Computer Searches of the NASA Information File to University Graduate Students in the Southeast. Final Report.

    ERIC Educational Resources Information Center

    Smetana, Frederick O.; Phillips, Dennis M.

    In an effort to increase dissemination of scientific and technological information, a program was undertaken whereby graduate students in science and engineering could request a computer-produced bibliography and/or abstracts of documents identified by the computer. The principal resource was the National Aeronautics and Space Administration…

  10. The first accurate description of an aurora

    NASA Astrophysics Data System (ADS)

    Schröder, Wilfried

    2006-12-01

    As technology has advanced, the scientific study of auroral phenomena has increased by leaps and bounds. A look back at the earliest descriptions of aurorae offers an interesting look into how medieval scholars viewed the subjects that we study.Although there are earlier fragmentary references in the literature, the first accurate description of the aurora borealis appears to be that published by the German Catholic scholar Konrad von Megenberg (1309-1374) in his book Das Buch der Natur (The Book of Nature). The book was written between 1349 and 1350.

  11. Are Kohn-Sham conductances accurate?

    PubMed

    Mera, H; Niquet, Y M

    2010-11-19

    We use Fermi-liquid relations to address the accuracy of conductances calculated from the single-particle states of exact Kohn-Sham (KS) density functional theory. We demonstrate a systematic failure of this procedure for the calculation of the conductance, and show how it originates from the lack of renormalization in the KS spectral function. In certain limits this failure can lead to a large overestimation of the true conductance. We also show, however, that the KS conductances can be accurate for single-channel molecular junctions and systems where direct Coulomb interactions are strongly dominant. PMID:21231333

  12. Accurate density functional thermochemistry for larger molecules.

    SciTech Connect

    Raghavachari, K.; Stefanov, B. B.; Curtiss, L. A.; Lucent Tech.

    1997-06-20

    Density functional methods are combined with isodesmic bond separation reaction energies to yield accurate thermochemistry for larger molecules. Seven different density functionals are assessed for the evaluation of heats of formation, Delta H 0 (298 K), for a test set of 40 molecules composed of H, C, O and N. The use of bond separation energies results in a dramatic improvement in the accuracy of all the density functionals. The B3-LYP functional has the smallest mean absolute deviation from experiment (1.5 kcal mol/f).

  13. Informing mental health policies and services in the EMR: cost-effective deployment of human resources to deliver integrated community-based care.

    PubMed

    Ivbijaro, G; Patel, V; Chisholm, D; Goldberg, D; Khoja, T A M; Edwards, T M; Enum, Y; Kolkiewic, L A

    2015-07-01

    For EMR countries to deliver the expectations of the Global Mental Health Action Plan 2013-2020 & the ongoing move towards universal health coverage, all health & social care providers need to innovate and transform their services to provide evidence-based health care that is accessible, cost-effective & with the best patient outcomes. For the primary and community workforce, this includes general medical practitioners, practice & community nurses, community social workers, housing officers, lay health workers, nongovernmental organizations & civil society, including community spiritual leaders/healers. This paper brings together the current best evidence to support transformation & discusses key approaches to achieve this, including skill mix and/or task shifting and integrated care. The important factors that need to be in place to support skill mix/task shifting and good integrated care are outlined with reference to EMR countries. PMID:26442888

  14. Equity flotation cost adjustments in utilities' cost of service

    SciTech Connect

    Bierman, H. Jr.; Hass, J.E.

    1984-03-01

    Recovery of the unavoidable costs of issuing new shares of stock is generally agreed to be appropriate in determining utility revenue requirements. This article suggests that the methods by which that is usually accomplished are of questionable accuracy. The conventional practice of adjusting the allowed rate of return on common equity is examined, and an improved adjustment formulation is presented. Acknowledging that application of the formula remains subject to considerable error, however, the authors propose yet another solution. Capitalization of flotation costs as intangible assets is suggested as a way of more accurately factoring such expenses into tariff determinations. 6 references.

  15. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with...

  16. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs, and.... Preliminary costs may include such items as feasibility surveys, engineering design, biological...

  17. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs, and.... Preliminary costs may include such items as feasibility surveys, engineering design, biological...

  18. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs, and.... Preliminary costs may include such items as feasibility surveys, engineering design, biological...

  19. 50 CFR 85.41 - Allowable costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... applicable Federal cost principles in 43 CFR 12.60(b). Purchase of informational signs, program signs, and.... Preliminary costs may include such items as feasibility surveys, engineering design, biological...

  20. 7 CFR 2903.4 - Indirect costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.4 Indirect costs. (a) For the Biodiesel Fuel Education Program, applicants should use the current indirect cost rate negotiated with...