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Sample records for accurate system matrix

  1. Fast and accurate computation of system matrix for area integral model-based algebraic reconstruction technique

    NASA Astrophysics Data System (ADS)

    Zhang, Shunli; Zhang, Dinghua; Gong, Hao; Ghasemalizadeh, Omid; Wang, Ge; Cao, Guohua

    2014-11-01

    Iterative algorithms, such as the algebraic reconstruction technique (ART), are popular for image reconstruction. For iterative reconstruction, the area integral model (AIM) is more accurate for better reconstruction quality than the line integral model (LIM). However, the computation of the system matrix for AIM is more complex and time-consuming than that for LIM. Here, we propose a fast and accurate method to compute the system matrix for AIM. First, we calculate the intersection of each boundary line of a narrow fan-beam with pixels in a recursive and efficient manner. Then, by grouping the beam-pixel intersection area into six types according to the slopes of the two boundary lines, we analytically compute the intersection area of the narrow fan-beam with the pixels in a simple algebraic fashion. Overall, experimental results show that our method is about three times faster than the Siddon algorithm and about two times faster than the distance-driven model (DDM) in computation of the system matrix. The reconstruction speed of our AIM-based ART is also faster than the LIM-based ART that uses the Siddon algorithm and DDM-based ART, for one iteration. The fast reconstruction speed of our method was accomplished without compromising the image quality.

  2. Matrix fractional systems

    NASA Astrophysics Data System (ADS)

    Tenreiro Machado, J. A.

    2015-08-01

    This paper addresses the matrix representation of dynamical systems in the perspective of fractional calculus. Fractional elements and fractional systems are interpreted under the light of the classical Cole-Cole, Davidson-Cole, and Havriliak-Negami heuristic models. Numerical simulations for an electrical circuit enlighten the results for matrix based models and high fractional orders. The conclusions clarify the distinction between fractional elements and fractional systems.

  3. MOP /Matrix Operation Programs system/

    NASA Technical Reports Server (NTRS)

    Muller, P. M.

    1968-01-01

    MOP /Matrix Operation Programs/ system consists of a set of FORTRAN 4 subroutines which are related through a small common allocation. The system accomplishes all matrix algebra operations plus related input-output and housekeeping details.

  4. How Accurately can we Calculate Thermal Systems?

    SciTech Connect

    Cullen, D; Blomquist, R N; Dean, C; Heinrichs, D; Kalugin, M A; Lee, M; Lee, Y; MacFarlan, R; Nagaya, Y; Trkov, A

    2004-04-20

    I would like to determine how accurately a variety of neutron transport code packages (code and cross section libraries) can calculate simple integral parameters, such as K{sub eff}, for systems that are sensitive to thermal neutron scattering. Since we will only consider theoretical systems, we cannot really determine absolute accuracy compared to any real system. Therefore rather than accuracy, it would be more precise to say that I would like to determine the spread in answers that we obtain from a variety of code packages. This spread should serve as an excellent indicator of how accurately we can really model and calculate such systems today. Hopefully, eventually this will lead to improvements in both our codes and the thermal scattering models that they use in the future. In order to accomplish this I propose a number of extremely simple systems that involve thermal neutron scattering that can be easily modeled and calculated by a variety of neutron transport codes. These are theoretical systems designed to emphasize the effects of thermal scattering, since that is what we are interested in studying. I have attempted to keep these systems very simple, and yet at the same time they include most, if not all, of the important thermal scattering effects encountered in a large, water-moderated, uranium fueled thermal system, i.e., our typical thermal reactors.

  5. Line gas sampling system ensures accurate analysis

    SciTech Connect

    Not Available

    1992-06-01

    Tremendous changes in the natural gas business have resulted in new approaches to the way natural gas is measured. Electronic flow measurement has altered the business forever, with developments in instrumentation and a new sensitivity to the importance of proper natural gas sampling techniques. This paper reports that YZ Industries Inc., Snyder, Texas, combined its 40 years of sampling experience with the latest in microprocessor-based technology to develop the KynaPak 2000 series, the first on-line natural gas sampling system that is both compact and extremely accurate. This means the composition of the sampled gas must be representative of the whole and related to flow. If so, relative measurement and sampling techniques are married, gas volumes are accurately accounted for and adjustments to composition can be made.

  6. Micron Accurate Absolute Ranging System: Range Extension

    NASA Technical Reports Server (NTRS)

    Smalley, Larry L.; Smith, Kely L.

    1999-01-01

    The purpose of this research is to investigate Fresnel diffraction as a means of obtaining absolute distance measurements with micron or greater accuracy. It is believed that such a system would prove useful to the Next Generation Space Telescope (NGST) as a non-intrusive, non-contact measuring system for use with secondary concentrator station-keeping systems. The present research attempts to validate past experiments and develop ways to apply the phenomena of Fresnel diffraction to micron accurate measurement. This report discusses past research on the phenomena, and the basis of the use Fresnel diffraction distance metrology. The apparatus used in the recent investigations, experimental procedures used, preliminary results are discussed in detail. Continued research and equipment requirements on the extension of the effective range of the Fresnel diffraction systems is also described.

  7. SMARTIES: Spheroids Modelled Accurately with a Robust T-matrix Implementation for Electromagnetic Scattering

    NASA Astrophysics Data System (ADS)

    Somerville, W. R. C.; Auguié, B.; Le Ru, E. C.

    2016-03-01

    SMARTIES calculates the optical properties of oblate and prolate spheroidal particles, with comparable capabilities and ease-of-use as Mie theory for spheres. This suite of MATLAB codes provides a fully documented implementation of an improved T-matrix algorithm for the theoretical modelling of electromagnetic scattering by particles of spheroidal shape. Included are scripts that cover a range of scattering problems relevant to nanophotonics and plasmonics, including calculation of far-field scattering and absorption cross-sections for fixed incidence orientation, orientation-averaged cross-sections and scattering matrix, surface-field calculations as well as near-fields, wavelength-dependent near-field and far-field properties, and access to lower-level functions implementing the T-matrix calculations, including the T-matrix elements which may be calculated more accurately than with competing codes.

  8. Accurate alignment of optical axes of a biplate using a spectroscopic Mueller matrix ellipsometer.

    PubMed

    Gu, Honggang; Chen, Xiuguo; Jiang, Hao; Zhang, Chuanwei; Li, Weiqi; Liu, Shiyuan

    2016-05-20

    The biplate that consists of two single wave plates made from birefringent materials with their fast axes oriented perpendicular to each other is one of the most commonly used retarders in many optical systems. The internal alignment of the optical axes of the two single wave plates is a key procedure in the fabrication and application of a biplate to reduce the spurious artifacts of oscillations in polarization properties due to the misalignment error and to improve the accuracy and precision of the systems using such biplates. In this paper, we propose a method to accurately align the axes of an arbitrary biplate by minimizing the oscillations in the characteristic parameter spectra of the biplate detected by a spectroscopic Mueller matrix ellipsometer (MME). We derived analytical relations between the characteristic parameters and the misalignment error in the biplate, which helps us to analyze the sensitivity of the characteristic parameters to the misalignment error and to evaluate the alignment accuracy quantitatively. Experimental results performed on a house-developed MME demonstrate that the alignment accuracy of the proposed method is better than 0.01° in aligning the optical axes of a quartz biplate.

  9. MEMS accelerometers in accurate mount positioning systems

    NASA Astrophysics Data System (ADS)

    Mészáros, László; Pál, András.; Jaskó, Attila

    2014-07-01

    In order to attain precise, accurate and stateless positioning of telescope mounts we apply microelectromechanical accelerometer systems (also known as MEMS accelerometers). In common practice, feedback from the mount position is provided by electronic, optical or magneto-mechanical systems or via real-time astrometric solution based on the acquired images. Hence, MEMS-based systems are completely independent from these mechanisms. Our goal is to investigate the advantages and challenges of applying such devices and to reach the sub-arcminute range { that is well smaller than the field-of-view of conventional imaging telescope systems. We present how this sub-arcminute accuracy can be achieved with very cheap MEMS sensors. Basically, these sensors yield raw output within an accuracy of a few degrees. We show what kind of calibration procedures could exploit spherical and cylindrical constraints between accelerometer output channels in order to achieve the previously mentioned accuracy level. We also demonstrate how can our implementation be inserted in a telescope control system. Although this attainable precision is less than both the resolution of telescope mount drive mechanics and the accuracy of astrometric solutions, the independent nature of attitude determination could significantly increase the reliability of autonomous or remotely operated astronomical observations.

  10. Approaching system equilibrium with accurate or not accurate feedback information in a two-route system

    NASA Astrophysics Data System (ADS)

    Zhao, Xiao-mei; Xie, Dong-fan; Li, Qi

    2015-02-01

    With the development of intelligent transport system, advanced information feedback strategies have been developed to reduce traffic congestion and enhance the capacity. However, previous strategies provide accurate information to travelers and our simulation results show that accurate information brings negative effects, especially in delay case. Because travelers prefer to the best condition route with accurate information, and delayed information cannot reflect current traffic condition but past. Then travelers make wrong routing decisions, causing the decrease of the capacity and the increase of oscillations and the system deviating from the equilibrium. To avoid the negative effect, bounded rationality is taken into account by introducing a boundedly rational threshold BR. When difference between two routes is less than the BR, routes have equal probability to be chosen. The bounded rationality is helpful to improve the efficiency in terms of capacity, oscillation and the gap deviating from the system equilibrium.

  11. System Matrix Analysis for Computed Tomography Imaging

    PubMed Central

    Flores, Liubov; Vidal, Vicent; Verdú, Gumersindo

    2015-01-01

    In practical applications of computed tomography imaging (CT), it is often the case that the set of projection data is incomplete owing to the physical conditions of the data acquisition process. On the other hand, the high radiation dose imposed on patients is also undesired. These issues demand that high quality CT images can be reconstructed from limited projection data. For this reason, iterative methods of image reconstruction have become a topic of increased research interest. Several algorithms have been proposed for few-view CT. We consider that the accurate solution of the reconstruction problem also depends on the system matrix that simulates the scanning process. In this work, we analyze the application of the Siddon method to generate elements of the matrix and we present results based on real projection data. PMID:26575482

  12. System Matrix Analysis for Computed Tomography Imaging.

    PubMed

    Flores, Liubov; Vidal, Vicent; Verdú, Gumersindo

    2015-01-01

    In practical applications of computed tomography imaging (CT), it is often the case that the set of projection data is incomplete owing to the physical conditions of the data acquisition process. On the other hand, the high radiation dose imposed on patients is also undesired. These issues demand that high quality CT images can be reconstructed from limited projection data. For this reason, iterative methods of image reconstruction have become a topic of increased research interest. Several algorithms have been proposed for few-view CT. We consider that the accurate solution of the reconstruction problem also depends on the system matrix that simulates the scanning process. In this work, we analyze the application of the Siddon method to generate elements of the matrix and we present results based on real projection data. PMID:26575482

  13. Matrix-vector multiplication using digital partitioning for more accurate optical computing

    NASA Technical Reports Server (NTRS)

    Gary, C. K.

    1992-01-01

    Digital partitioning offers a flexible means of increasing the accuracy of an optical matrix-vector processor. This algorithm can be implemented with the same architecture required for a purely analog processor, which gives optical matrix-vector processors the ability to perform high-accuracy calculations at speeds comparable with or greater than electronic computers as well as the ability to perform analog operations at a much greater speed. Digital partitioning is compared with digital multiplication by analog convolution, residue number systems, and redundant number representation in terms of the size and the speed required for an equivalent throughput as well as in terms of the hardware requirements. Digital partitioning and digital multiplication by analog convolution are found to be the most efficient alogrithms if coding time and hardware are considered, and the architecture for digital partitioning permits the use of analog computations to provide the greatest throughput for a single processor.

  14. A unique, accurate LWIR optics measurement system

    NASA Astrophysics Data System (ADS)

    Fantone, Stephen D.; Orband, Daniel G.

    2011-05-01

    A compact low-cost LWIR test station has been developed that provides real time MTF testing of IR optical systems and EO imaging systems. The test station is intended to be operated by a technician and can be used to measure the focal length, blur spot size, distortion, and other metrics of system performance. The challenges and tradeoffs incorporated into this instrumentation will be presented. The test station performs the measurement of an IR lens or optical system's first order quantities (focal length, back focal length) including on and off-axis imaging performance (e.g., MTF, resolution, spot size) under actual test conditions to enable the simulation of their actual use. Also described is the method of attaining the needed accuracies so that derived calculations like focal length (EFL = image shift/tan(theta)) can be performed to the requisite accuracy. The station incorporates a patented video capture technology and measures MTF and blur characteristics using newly available lowcost LWIR cameras. This allows real time determination of the optical system performance enabling faster measurements, higher throughput and lower cost results than scanning systems. Multiple spectral filters are also accommodated within the test stations which facilitate performance evaluation under various spectral conditions.

  15. SOPROLIFE System: An Accurate Diagnostic Enhancer

    PubMed Central

    Zeitouny, Mona; Feghali, Mireille; Nasr, Assaad; Abou-Samra, Philippe; Saleh, Nadine; Bourgeois, Denis; Farge, Pierre

    2014-01-01

    Objectives. The aim of this study was to evaluate a light-emitting diode fluorescence tool, the SOPROLIFE light-induced fluorescence evaluator, and compare it to the international caries detection and assessment system-II (ICDAS-II) in the detection of occlusal caries. Methods. A total of 219 permanent posterior teeth in 21 subjects, with age ranging from 15 to 65 years, were examined. An intraclass correlation coefficient (ICC) was computed to assess the reliability between the two diagnostic methods. Results. The results showed a high reliability between the two methods (ICC = 0.92; IC = 0.901–0.940; P < 0.001). The SOPROLIFE blue fluorescence mode had a high sensitivity (87%) and a high specificity (99%) when compared to ICDAS-II. Conclusion. Compared to the most used visual method in the diagnosis of occlusal caries lesions, the finding from this study suggests that SOPROLIFE can be used as a reproducible and reliable assessment tool. At a cut-off point, categorizing noncarious lesions and visual change in enamel, SOPROLIFE shows a high sensitivity and specificity. We can conclude that financially ICDAS is better than SOPROLIFE. However SOPROLIFE is easier for clinicians since it is a simple evaluation of images. Finally in terms of efficiency SOPROLIFE is not superior to ICDAS but tends to be equivalent with the same advantages. PMID:25401161

  16. Modified transfer matrix method for asymmetric rotor-bearing systems

    NASA Astrophysics Data System (ADS)

    Kang, Yuan; Lee, An-Chen; Shih, Yuan-Pin

    1994-07-01

    A modified transfer matrix method (MTMM) is developed to analyze rotor-bearing systems with an asymmetric shaft and asymmetric disks. The rotating shaft is modeled by a Rayleigh-Euler beam considering the effects of the rotary inertia and gyroscopic moments. Specifically, a transfer matrix of the asymmetric shaft segments is derived in a continuous-system sense to give accurate solutions. The harmonic balance method is incorporated in the transfer matrix equations, so that steady-state responses of synchronous and superharmonic whirls can be determined. A numerical example is presented to demonstrate the effectiveness of this approach.

  17. Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) Mass Spectrometry Using the Vitek MS System for Rapid and Accurate Identification of Dermatophytes on Solid Cultures

    PubMed Central

    Monnin, Valérie; Girard, Victoria; Welker, Martin; Arsac, Maud; Cellière, Béatrice; Durand, Géraldine; Bosshard, Philipp P.; Farina, Claudio; Passera, Marco; Van Belkum, Alex; Petrini, Orlando; Tonolla, Mauro

    2014-01-01

    The objective of this research was to extend the Vitek MS fungal knowledge base version 2.0.0 to allow the robust identification of clinically relevant dermatophytes, using a variety of strains, incubation times, and growth conditions. First, we established a quick and reliable method for sample preparation to obtain a reliable and reproducible identification independently of the growth conditions. The Vitek MS V2.0.0 fungal knowledge base was then expanded using 134 well-characterized strains belonging to 17 species in the genera Epidermophyton, Microsporum, and Trichophyton. Cluster analysis based on mass spectrum similarity indicated good species discrimination independently of the culture conditions. We achieved a good separation of the subpopulations of the Trichophyton anamorph of Arthroderma benhamiae and of anthropophilic and zoophilic strains of Trichophyton interdigitale. Overall, the 1,130 mass spectra obtained for dermatophytes gave an estimated identification performance of 98.4%. The expanded fungal knowledge base was then validated using 131 clinical isolates of dermatophytes belonging to 13 taxa. For 8 taxa all strains were correctly identified, and for 3 the rate of successful identification was >90%; 75% (6/8) of the M. gypseum strains were correctly identified, whereas only 47% (18/38) of the African T. rubrum population (also called T. soudanense) were recognized accurately, with a large quantity of strains misidentified as T. violaceum, demonstrating the close relationship of these two taxa. The method of sample preparation was fast and efficient and the expanded Vitek MS fungal knowledge base reliable and robust, allowing reproducible dermatophyte identifications in the routine laboratory. PMID:25297329

  18. Density matrix embedding theory for interacting electron-phonon systems

    NASA Astrophysics Data System (ADS)

    Sandhoefer, Barbara; Chan, Garnet Kin-Lic

    2016-08-01

    We describe the extension of the density matrix embedding theory framework to coupled interacting fermion-boson systems. This provides a frequency-independent, entanglement embedding formalism to treat bulk fermion-boson problems. We illustrate the concepts within the context of the one-dimensional Hubbard-Holstein model, where the phonon bath states are obtained from the Schmidt decomposition of a self-consistently adjusted coherent state. We benchmark our results against accurate density matrix renormalization group calculations.

  19. Extracellular Matrix: Functions in the Nervous System

    PubMed Central

    Barros, Claudia S.; Franco, Santos J.; Müller, Ulrich

    2011-01-01

    An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system. PMID:21123393

  20. An accurate quantum expression of the z-dipole matrix element between nearby Rydberg parabolic states and the correspondence principle

    NASA Astrophysics Data System (ADS)

    Dewangan, D. P.

    2008-01-01

    We give an exact quantum formula for the z-component of the dipole matrix element between parabolic states of a hydrogen atom in terms of the Jacobi polynomials. The formula extends the range of numerical computation to larger values of the parabolic quantum numbers for which computation from the standard textbook formula, which is in terms of the hypergeometric functions, is defined. We obtain an accurate quantum expression of the z-dipole matrix element in terms of the ordinary Bessel functions for transition between nearby Rydberg parabolic states. We derive for the first time the formula of the z-dipole matrix element of the correspondence principle method directly from the quantum expression, and in the process of derivation, clarify the nature of classical-quantum correspondence. The expressions obtained in this work solve the problem of computation of the z-dipole matrix element of hydrogen to a large extent.

  1. Laser Guided Automated Calibrating System for Accurate Bracket Placement

    PubMed Central

    Anitha, A; Kumar, AJ; Mascarenhas, R; Husain, A

    2015-01-01

    Background: The basic premise of preadjusted bracket system is accurate bracket positioning. It is widely recognized that accurate bracket placement is of critical importance in the efficient application of biomechanics and in realizing the full potential of a preadjusted edgewise appliance. Aim: The purpose of this study was to design a calibrating system to accurately detect a point on a plane as well as to determine the accuracy of the Laser Guided Automated Calibrating (LGAC) System. Materials and Methods: To the lowest order of approximation a plane having two parallel lines is used to verify the accuracy of the system. On prescribing the distance of a point from the line, images of the plane are analyzed from controlled angles, calibrated and the point is identified with a laser marker. Results: The image was captured and analyzed using MATLAB ver. 7 software (The MathWorks Inc.). Each pixel in the image corresponded to a distance of 1cm/413 (10 mm/413) = 0.0242 mm (L/P). This implies any variations in distance above 0.024 mm can be measured and acted upon, and sets the highest possible accuracy for this system. Conclusion: A new automated system is introduced having an accuracy of 0.024 mm for accurate bracket placement. PMID:25745575

  2. Videometric terminal guidance method and system for UAV accurate landing

    NASA Astrophysics Data System (ADS)

    Zhou, Xiang; Lei, Zhihui; Yu, Qifeng; Zhang, Hongliang; Shang, Yang; Du, Jing; Gui, Yang; Guo, Pengyu

    2012-06-01

    We present a videometric method and system to implement terminal guidance for Unmanned Aerial Vehicle(UAV) accurate landing. In the videometric system, two calibrated cameras attached to the ground are used, and a calibration method in which at least 5 control points are applied is developed to calibrate the inner and exterior parameters of the cameras. Cameras with 850nm spectral filter are used to recognize a 850nm LED target fixed on the UAV which can highlight itself in images with complicated background. NNLOG (normalized negative laplacian of gaussian) operator is developed for automatic target detection and tracking. Finally, 3-D position of the UAV with high accuracy can be calculated and transfered to control system to direct UAV accurate landing. The videometric system can work in the rate of 50Hz. Many real flight and static accuracy experiments demonstrate the correctness and veracity of the method proposed in this paper, and they also indicate the reliability and robustness of the system proposed in this paper. The static accuracy experiment results show that the deviation is less-than 10cm when target is far from the cameras and lessthan 2cm in 100m region. The real flight experiment results show that the deviation from DGPS is less-than 20cm. The system implement in this paper won the first prize in the AVIC Cup-International UAV Innovation Grand Prix, and it is the only one that achieved UAV accurate landing without GPS or DGPS.

  3. Calibration Techniques for Accurate Measurements by Underwater Camera Systems.

    PubMed

    Shortis, Mark

    2015-12-07

    Calibration of a camera system is essential to ensure that image measurements result in accurate estimates of locations and dimensions within the object space. In the underwater environment, the calibration must implicitly or explicitly model and compensate for the refractive effects of waterproof housings and the water medium. This paper reviews the different approaches to the calibration of underwater camera systems in theoretical and practical terms. The accuracy, reliability, validation and stability of underwater camera system calibration are also discussed. Samples of results from published reports are provided to demonstrate the range of possible accuracies for the measurements produced by underwater camera systems.

  4. Calibration Techniques for Accurate Measurements by Underwater Camera Systems

    PubMed Central

    Shortis, Mark

    2015-01-01

    Calibration of a camera system is essential to ensure that image measurements result in accurate estimates of locations and dimensions within the object space. In the underwater environment, the calibration must implicitly or explicitly model and compensate for the refractive effects of waterproof housings and the water medium. This paper reviews the different approaches to the calibration of underwater camera systems in theoretical and practical terms. The accuracy, reliability, validation and stability of underwater camera system calibration are also discussed. Samples of results from published reports are provided to demonstrate the range of possible accuracies for the measurements produced by underwater camera systems. PMID:26690172

  5. Calibration Techniques for Accurate Measurements by Underwater Camera Systems.

    PubMed

    Shortis, Mark

    2015-01-01

    Calibration of a camera system is essential to ensure that image measurements result in accurate estimates of locations and dimensions within the object space. In the underwater environment, the calibration must implicitly or explicitly model and compensate for the refractive effects of waterproof housings and the water medium. This paper reviews the different approaches to the calibration of underwater camera systems in theoretical and practical terms. The accuracy, reliability, validation and stability of underwater camera system calibration are also discussed. Samples of results from published reports are provided to demonstrate the range of possible accuracies for the measurements produced by underwater camera systems. PMID:26690172

  6. Accurate Parameter Estimation for Unbalanced Three-Phase System

    PubMed Central

    Chen, Yuan

    2014-01-01

    Smart grid is an intelligent power generation and control console in modern electricity networks, where the unbalanced three-phase power system is the commonly used model. Here, parameter estimation for this system is addressed. After converting the three-phase waveforms into a pair of orthogonal signals via the α β-transformation, the nonlinear least squares (NLS) estimator is developed for accurately finding the frequency, phase, and voltage parameters. The estimator is realized by the Newton-Raphson scheme, whose global convergence is studied in this paper. Computer simulations show that the mean square error performance of NLS method can attain the Cramér-Rao lower bound. Moreover, our proposal provides more accurate frequency estimation when compared with the complex least mean square (CLMS) and augmented CLMS. PMID:25162056

  7. Accurate parameter estimation for unbalanced three-phase system.

    PubMed

    Chen, Yuan; So, Hing Cheung

    2014-01-01

    Smart grid is an intelligent power generation and control console in modern electricity networks, where the unbalanced three-phase power system is the commonly used model. Here, parameter estimation for this system is addressed. After converting the three-phase waveforms into a pair of orthogonal signals via the α β-transformation, the nonlinear least squares (NLS) estimator is developed for accurately finding the frequency, phase, and voltage parameters. The estimator is realized by the Newton-Raphson scheme, whose global convergence is studied in this paper. Computer simulations show that the mean square error performance of NLS method can attain the Cramér-Rao lower bound. Moreover, our proposal provides more accurate frequency estimation when compared with the complex least mean square (CLMS) and augmented CLMS.

  8. Numerical Computation of a Continuous-thrust State Transition Matrix Incorporating Accurate Hardware and Ephemeris Models

    NASA Technical Reports Server (NTRS)

    Ellison, Donald; Conway, Bruce; Englander, Jacob

    2015-01-01

    A significant body of work exists showing that providing a nonlinear programming (NLP) solver with expressions for the problem constraint gradient substantially increases the speed of program execution and can also improve the robustness of convergence, especially for local optimizers. Calculation of these derivatives is often accomplished through the computation of spacecraft's state transition matrix (STM). If the two-body gravitational model is employed as is often done in the context of preliminary design, closed form expressions for these derivatives may be provided. If a high fidelity dynamics model, that might include perturbing forces such as the gravitational effect from multiple third bodies and solar radiation pressure is used then these STM's must be computed numerically. We present a method for the power hardward model and a full ephemeris model. An adaptive-step embedded eight order Dormand-Prince numerical integrator is discussed and a method for the computation of the time of flight derivatives in this framework is presented. The use of these numerically calculated derivatieves offer a substantial improvement over finite differencing in the context of a global optimizer. Specifically the inclusion of these STM's into the low thrust missiondesign tool chain in use at NASA Goddard Spaceflight Center allows for an increased preliminary mission design cadence.

  9. Accurate object tracking system by integrating texture and depth cues

    NASA Astrophysics Data System (ADS)

    Chen, Ju-Chin; Lin, Yu-Hang

    2016-03-01

    A robust object tracking system that is invariant to object appearance variations and background clutter is proposed. Multiple instance learning with a boosting algorithm is applied to select discriminant texture information between the object and background data. Additionally, depth information, which is important to distinguish the object from a complicated background, is integrated. We propose two depth-based models that can compensate texture information to cope with both appearance variants and background clutter. Moreover, in order to reduce the risk of drifting problem increased for the textureless depth templates, an update mechanism is proposed to select more precise tracking results to avoid incorrect model updates. In the experiments, the robustness of the proposed system is evaluated and quantitative results are provided for performance analysis. Experimental results show that the proposed system can provide the best success rate and has more accurate tracking results than other well-known algorithms.

  10. Efficient and accurate treatment of electron correlations with correlation matrix renormalization theory

    DOE PAGES

    Yao, Y. X.; Liu, J.; Liu, C.; Lu, W. C.; Wang, C. Z.; Ho, K. M.

    2015-08-28

    We present an efficient method for calculating the electronic structure and total energy of strongly correlated electron systems. The method extends the traditional Gutzwiller approximation for one-particle operators to the evaluation of the expectation values of two particle operators in the many-electron Hamiltonian. The method is free of adjustable Coulomb parameters, and has no double counting issues in the calculation of total energy, and has the correct atomic limit. We demonstrate that the method describes well the bonding and dissociation behaviors of the hydrogen and nitrogen clusters, as well as the ammonia composed of hydrogen and nitrogen atoms. We alsomore » show that the method can satisfactorily tackle great challenging problems faced by the density functional theory recently discussed in the literature. The computational workload of our method is similar to the Hartree-Fock approach while the results are comparable to high-level quantum chemistry calculations.« less

  11. Efficient and accurate treatment of electron correlations with correlation matrix renormalization theory

    SciTech Connect

    Yao, Y. X.; Liu, J.; Liu, C.; Lu, W. C.; Wang, C. Z.; Ho, K. M.

    2015-08-28

    We present an efficient method for calculating the electronic structure and total energy of strongly correlated electron systems. The method extends the traditional Gutzwiller approximation for one-particle operators to the evaluation of the expectation values of two particle operators in the many-electron Hamiltonian. The method is free of adjustable Coulomb parameters, and has no double counting issues in the calculation of total energy, and has the correct atomic limit. We demonstrate that the method describes well the bonding and dissociation behaviors of the hydrogen and nitrogen clusters, as well as the ammonia composed of hydrogen and nitrogen atoms. We also show that the method can satisfactorily tackle great challenging problems faced by the density functional theory recently discussed in the literature. The computational workload of our method is similar to the Hartree-Fock approach while the results are comparable to high-level quantum chemistry calculations.

  12. Efficient and accurate treatment of electron correlations with Correlation Matrix Renormalization theory

    NASA Astrophysics Data System (ADS)

    Yao, Y. X.; Liu, J.; Liu, C.; Lu, W. C.; Wang, C. Z.; Ho, K. M.

    2015-08-01

    We present an efficient method for calculating the electronic structure and total energy of strongly correlated electron systems. The method extends the traditional Gutzwiller approximation for one-particle operators to the evaluation of the expectation values of two particle operators in the many-electron Hamiltonian. The method is free of adjustable Coulomb parameters, and has no double counting issues in the calculation of total energy, and has the correct atomic limit. We demonstrate that the method describes well the bonding and dissociation behaviors of the hydrogen and nitrogen clusters, as well as the ammonia composed of hydrogen and nitrogen atoms. We also show that the method can satisfactorily tackle great challenging problems faced by the density functional theory recently discussed in the literature. The computational workload of our method is similar to the Hartree-Fock approach while the results are comparable to high-level quantum chemistry calculations.

  13. Efficient and accurate treatment of electron correlations with Correlation Matrix Renormalization theory

    PubMed Central

    Yao, Y. X.; Liu, J.; Liu, C.; Lu, W. C.; Wang, C. Z.; Ho, K. M.

    2015-01-01

    We present an efficient method for calculating the electronic structure and total energy of strongly correlated electron systems. The method extends the traditional Gutzwiller approximation for one-particle operators to the evaluation of the expectation values of two particle operators in the many-electron Hamiltonian. The method is free of adjustable Coulomb parameters, and has no double counting issues in the calculation of total energy, and has the correct atomic limit. We demonstrate that the method describes well the bonding and dissociation behaviors of the hydrogen and nitrogen clusters, as well as the ammonia composed of hydrogen and nitrogen atoms. We also show that the method can satisfactorily tackle great challenging problems faced by the density functional theory recently discussed in the literature. The computational workload of our method is similar to the Hartree-Fock approach while the results are comparable to high-level quantum chemistry calculations. PMID:26315767

  14. A Highly Accurate Face Recognition System Using Filtering Correlation

    NASA Astrophysics Data System (ADS)

    Watanabe, Eriko; Ishikawa, Sayuri; Kodate, Kashiko

    2007-09-01

    The authors previously constructed a highly accurate fast face recognition optical correlator (FARCO) [E. Watanabe and K. Kodate: Opt. Rev. 12 (2005) 460], and subsequently developed an improved, super high-speed FARCO (S-FARCO), which is able to process several hundred thousand frames per second. The principal advantage of our new system is its wide applicability to any correlation scheme. Three different configurations were proposed, each depending on correlation speed. This paper describes and evaluates a software correlation filter. The face recognition function proved highly accurate, seeing that a low-resolution facial image size (64 × 64 pixels) has been successfully implemented. An operation speed of less than 10 ms was achieved using a personal computer with a central processing unit (CPU) of 3 GHz and 2 GB memory. When we applied the software correlation filter to a high-security cellular phone face recognition system, experiments on 30 female students over a period of three months yielded low error rates: 0% false acceptance rate and 2% false rejection rate. Therefore, the filtering correlation works effectively when applied to low resolution images such as web-based images or faces captured by a monitoring camera.

  15. The Global Geodetic Infrastructure for Accurate Monitoring of Earth Systems

    NASA Astrophysics Data System (ADS)

    Weston, Neil; Blackwell, Juliana; Wang, Yan; Willis, Zdenka

    2014-05-01

    The National Geodetic Survey (NGS) and the Integrated Ocean Observing System (IOOS), two Program Offices within the National Ocean Service, NOAA, routinely collect, analyze and disseminate observations and products from several of the 17 critical systems identified by the U.S. Group on Earth Observations. Gravity, sea level monitoring, coastal zone and ecosystem management, geo-hazards and deformation monitoring and ocean surface vector winds are the primary Earth systems that have active research and operational programs in NGS and IOOS. These Earth systems collect terrestrial data but most rely heavily on satellite-based sensors for analyzing impacts and monitoring global change. One fundamental component necessary for monitoring via satellites is having a stable, global geodetic infrastructure where an accurate reference frame is essential for consistent data collection and geo-referencing. This contribution will focus primarily on system monitoring, coastal zone management and global reference frames and how the scientific contributions from NGS and IOOS continue to advance our understanding of the Earth and the Global Geodetic Observing System.

  16. Simple and accurate optical height sensor for wafer inspection systems

    NASA Astrophysics Data System (ADS)

    Shimura, Kei; Nakai, Naoya; Taniguchi, Koichi; Itoh, Masahide

    2016-02-01

    An accurate method for measuring the wafer surface height is required for wafer inspection systems to adjust the focus of inspection optics quickly and precisely. A method for projecting a laser spot onto the wafer surface obliquely and for detecting its image displacement using a one-dimensional position-sensitive detector is known, and a variety of methods have been proposed for improving the accuracy by compensating the measurement error due to the surface patterns. We have developed a simple and accurate method in which an image of a reticle with eight slits is projected on the wafer surface and its reflected image is detected using an image sensor. The surface height is calculated by averaging the coordinates of the images of the slits in both the two directions in the captured image. Pattern-related measurement error was reduced by applying the coordinates averaging to the multiple-slit-projection method. Accuracy of better than 0.35 μm was achieved for a patterned wafer at the reference height and ±0.1 mm from the reference height in a simple configuration.

  17. Personalized Orthodontic Accurate Tooth Arrangement System with Complete Teeth Model.

    PubMed

    Cheng, Cheng; Cheng, Xiaosheng; Dai, Ning; Liu, Yi; Fan, Qilei; Hou, Yulin; Jiang, Xiaotong

    2015-09-01

    The accuracy, validity and lack of relation information between dental root and jaw in tooth arrangement are key problems in tooth arrangement technology. This paper aims to describe a newly developed virtual, personalized and accurate tooth arrangement system based on complete information about dental root and skull. Firstly, a feature constraint database of a 3D teeth model is established. Secondly, for computed simulation of tooth movement, the reference planes and lines are defined by the anatomical reference points. The matching mathematical model of teeth pattern and the principle of the specific pose transformation of rigid body are fully utilized. The relation of position between dental root and alveolar bone is considered during the design process. Finally, the relative pose relationships among various teeth are optimized using the object mover, and a personalized therapeutic schedule is formulated. Experimental results show that the virtual tooth arrangement system can arrange abnormal teeth very well and is sufficiently flexible. The relation of position between root and jaw is favorable. This newly developed system is characterized by high-speed processing and quantitative evaluation of the amount of 3D movement of an individual tooth.

  18. Transfer matrix method for multibody systems for piezoelectric stack actuators

    NASA Astrophysics Data System (ADS)

    Zhu, Wei; Chen, Gangli; Bian, Leixiang; Rui, Xiaoting

    2014-09-01

    In order to achieve a large displacement output from a piezoelectric actuator, we realized the piezoelectric stack actuator (PSA) by mechanically layering/stacking multi-chip piezoelectric wafers in a series and electrically connecting the electrodes in parallel. In this paper, in order to accurately model the hysteresis and the dynamic characteristics of a PSA, the transfer matrix method for multibody systems (MSTMM) was adopted to describe the dynamic characteristics, and the Bouc-Wen hysteresis operator was used to represent the hysteresis. The vibration characteristics of a PSA and a piezo-actuated positioning mechanism (PPM) are derived and analyzed by the MSTMM; then, the dynamic responses of the PSA and the PPM are calculated. The experimental results show that the new method can accurately portray the hysteresis and the dynamic characteristics of a PSA and a PPM. On one hand, if we use this method to model the dynamic response of the PSA and the PPM, the PSA can be considered as a flexible body, as opposed to a mass-spring-damper system, which is in better agreement with the actual condition. On the other hand, the global dynamics equation is not needed for the study of system dynamics, and the dynamics equation has a small-sized matrix and a higher computational speed. Therefore, this method gives a broad range of possibilities for model-based controller design.

  19. Accurate dispensing system for single oocytes using air ejection

    PubMed Central

    Feng, Lin; Sun, Yiling; Ohsumi, Chisato; Arai, Fumihito

    2013-01-01

    In this study, we propose a new approach to increase the success rate of single-oocyte dispensing and investigate the subsequent viability of the dispensed oocytes. We used a pair of capacitance sensors placed in a microfluidic chip to detect the oocyte, and custom-designed a special buffer zone in the microchannel to decelerate the flow velocity and reduce the hydraulic pressure acting on the oocyte. In the buffer zone, a semicircular bay, formed by equally spaced micro-pillars, is used to stop the oocyte at the dispensing nozzle hole. Finally, the oocyte is ejected by airflow to the culture array. The novel feature of the developed microfluidic system is that the extraordinary improvement in success rate is accompanied by a lack of change in oocyte survival rate (as assessed by a comparison of survival rates before and after the dispensing procedure). By using this device, we achieved a highly accurate single-oocyte dispensing process with a success rate of 100%. The oocyte survival rate is approximately 70%, regardless of whether or not the oocyte is dispensed. The newly proposed system has the advantages of high operation speed and potential usage for two-dimensional micropatterning. PMID:24404076

  20. Accurate measurement of RF exposure from emerging wireless communication systems

    NASA Astrophysics Data System (ADS)

    Letertre, Thierry; Monebhurrun, Vikass; Toffano, Zeno

    2013-04-01

    Isotropic broadband probes or spectrum analyzers (SAs) may be used for the measurement of rapidly varying electromagnetic fields generated by emerging wireless communication systems. In this paper this problematic is investigated by comparing the responses measured by two different isotropic broadband probes typically used to perform electric field (E-field) evaluations. The broadband probes are submitted to signals with variable duty cycles (DC) and crest factors (CF) either with or without Orthogonal Frequency Division Multiplexing (OFDM) modulation but with the same root-mean-square (RMS) power. The two probes do not provide accurate enough results for deterministic signals such as Worldwide Interoperability for Microwave Access (WIMAX) or Long Term Evolution (LTE) as well as for non-deterministic signals such as Wireless Fidelity (WiFi). The legacy measurement protocols should be adapted to cope for the emerging wireless communication technologies based on the OFDM modulation scheme. This is not easily achieved except when the statistics of the RF emission are well known. In this case the measurement errors are shown to be systematic and a correction factor or calibration can be applied to obtain a good approximation of the total RMS power.

  1. Iterative reconstruction using a Monte Carlo based system transfer matrix for dedicated breast positron emission tomography

    SciTech Connect

    Saha, Krishnendu; Straus, Kenneth J.; Glick, Stephen J.; Chen, Yu.

    2014-08-28

    To maximize sensitivity, it is desirable that ring Positron Emission Tomography (PET) systems dedicated for imaging the breast have a small bore. Unfortunately, due to parallax error this causes substantial degradation in spatial resolution for objects near the periphery of the breast. In this work, a framework for computing and incorporating an accurate system matrix into iterative reconstruction is presented in an effort to reduce spatial resolution degradation towards the periphery of the breast. The GATE Monte Carlo Simulation software was utilized to accurately model the system matrix for a breast PET system. A strategy for increasing the count statistics in the system matrix computation and for reducing the system element storage space was used by calculating only a subset of matrix elements and then estimating the rest of the elements by using the geometric symmetry of the cylindrical scanner. To implement this strategy, polar voxel basis functions were used to represent the object, resulting in a block-circulant system matrix. Simulation studies using a breast PET scanner model with ring geometry demonstrated improved contrast at 45% reduced noise level and 1.5 to 3 times resolution performance improvement when compared to MLEM reconstruction using a simple line-integral model. The GATE based system matrix reconstruction technique promises to improve resolution and noise performance and reduce image distortion at FOV periphery compared to line-integral based system matrix reconstruction.

  2. Iterative reconstruction using a Monte Carlo based system transfer matrix for dedicated breast positron emission tomography

    NASA Astrophysics Data System (ADS)

    Saha, Krishnendu; Straus, Kenneth J.; Chen, Yu.; Glick, Stephen J.

    2014-08-01

    To maximize sensitivity, it is desirable that ring Positron Emission Tomography (PET) systems dedicated for imaging the breast have a small bore. Unfortunately, due to parallax error this causes substantial degradation in spatial resolution for objects near the periphery of the breast. In this work, a framework for computing and incorporating an accurate system matrix into iterative reconstruction is presented in an effort to reduce spatial resolution degradation towards the periphery of the breast. The GATE Monte Carlo Simulation software was utilized to accurately model the system matrix for a breast PET system. A strategy for increasing the count statistics in the system matrix computation and for reducing the system element storage space was used by calculating only a subset of matrix elements and then estimating the rest of the elements by using the geometric symmetry of the cylindrical scanner. To implement this strategy, polar voxel basis functions were used to represent the object, resulting in a block-circulant system matrix. Simulation studies using a breast PET scanner model with ring geometry demonstrated improved contrast at 45% reduced noise level and 1.5 to 3 times resolution performance improvement when compared to MLEM reconstruction using a simple line-integral model. The GATE based system matrix reconstruction technique promises to improve resolution and noise performance and reduce image distortion at FOV periphery compared to line-integral based system matrix reconstruction.

  3. Iterative reconstruction using a Monte Carlo based system transfer matrix for dedicated breast positron emission tomography.

    PubMed

    Saha, Krishnendu; Straus, Kenneth J; Chen, Yu; Glick, Stephen J

    2014-08-28

    To maximize sensitivity, it is desirable that ring Positron Emission Tomography (PET) systems dedicated for imaging the breast have a small bore. Unfortunately, due to parallax error this causes substantial degradation in spatial resolution for objects near the periphery of the breast. In this work, a framework for computing and incorporating an accurate system matrix into iterative reconstruction is presented in an effort to reduce spatial resolution degradation towards the periphery of the breast. The GATE Monte Carlo Simulation software was utilized to accurately model the system matrix for a breast PET system. A strategy for increasing the count statistics in the system matrix computation and for reducing the system element storage space was used by calculating only a subset of matrix elements and then estimating the rest of the elements by using the geometric symmetry of the cylindrical scanner. To implement this strategy, polar voxel basis functions were used to represent the object, resulting in a block-circulant system matrix. Simulation studies using a breast PET scanner model with ring geometry demonstrated improved contrast at 45% reduced noise level and 1.5 to 3 times resolution performance improvement when compared to MLEM reconstruction using a simple line-integral model. The GATE based system matrix reconstruction technique promises to improve resolution and noise performance and reduce image distortion at FOV periphery compared to line-integral based system matrix reconstruction.

  4. Generating Nice Linear Systems for Matrix Gaussian Elimination

    ERIC Educational Resources Information Center

    Homewood, L. James

    2004-01-01

    In this article an augmented matrix that represents a system of linear equations is called nice if a sequence of elementary row operations that reduces the matrix to row-echelon form, through matrix Gaussian elimination, does so by restricting all entries to integers in every step. Many instructors wish to use the example of matrix Gaussian…

  5. Boost matrix converters in clean energy systems

    NASA Astrophysics Data System (ADS)

    Karaman, Ekrem

    This dissertation describes an investigation of novel power electronic converters, based on the ultra-sparse matrix topology and characterized by the minimum number of semiconductor switches. The Z-source, Quasi Z-source, Series Z-source and Switched-inductor Z-source networks were originally proposed for boosting the output voltage of power electronic inverters. These ideas were extended here on three-phase to three-phase and three-phase to single-phase indirect matrix converters. For the three-phase to three-phase matrix converters, the Z-source networks are placed between the three-switch input rectifier stage and the output six-switch inverter stage. A brief shoot-through state produces the voltage boost. An optimal pulse width modulation technique was developed to achieve high boosting capability and minimum switching losses in the converter. For the three-phase to single-phase matrix converters, those networks are placed similarly. For control purposes, a new modulation technique has been developed. As an example application, the proposed converters constitute a viable alternative to the existing solutions in residential wind-energy systems, where a low-voltage variable-speed generator feeds power to the higher-voltage fixed-frequency grid. Comprehensive analytical derivations and simulation results were carried out to investigate the operation of the proposed converters. Performance of the proposed converters was then compared between each other as well as with conventional converters. The operation of the converters was experimentally validated using a laboratory prototype.

  6. Theoretical Studies of the Relaxation Matrix for Molecular Systems

    NASA Astrophysics Data System (ADS)

    Ma, Qiancheng; Boulet, C.

    2016-06-01

    The phenomenon of collisional transfer of intensity due to line mixing has an increasing importance for atmospheric monitoring. From a theoretical point of view, all relevant information about the collisional processes is contained in the relaxation matrix where the diagonal elements give half-widths and shifts, and the off-diagonal elements correspond to line interferences. For simple systems such as those consisting of diatom-atom or diatom-diatom, accurate fully quantum calculations based on interaction potentials are feasible. However, fully quantum calculations become unrealistic for more complex systems. On the other hand, the semi-classical Robert-Bonamy formalism, which has been widely used to calculate half-widths and shifts for decades, fails in calculating the off-diagonal matrix elements resulting from applying the isolated line approximation. As a result, in order to simulate atmospheric spectra where the effects from line mixing are important, semi-empirical fitting or scaling laws such as the energy corrected sudden (ECS) and the infinite order sudden (IOS) models are commonly used. Recently, we have found that in developing this semi-classical line shape theory, to rely on the isolated line approximation is not necessary. By eliminating this unjustified assumption, and accurately evaluating matrix elements of the exponential operators, we have developed a more capable formalism that enables one not only to reduce uncertainties for calculated half-widths and shifts, but also to calculate the whole relaxation matrix. This implies that we can address the line mixing with the semi-classical theory based on interaction potentials between molecular absorber and molecular perturber. We have applied this formalism for Raman and infrared spectra of linear and asymmetric-top molecules. Recently, the method has been extended into symmetric-tops with inverse symmetry such as the NH3 molecule. Our calculated half-widths of NH3 lines in the νb{1} and the pure

  7. Digraph matrix analysis applications to systems interactions

    SciTech Connect

    Alesso, H.P.; Altenbach, T.; Lappa, D.; Kimura, C.; Sacks, I.J.; Ashmore, B.C.; Fromme, D.; Smith, C.F.; Williams, W.

    1984-01-01

    Complex events such as Three Mile Island-2, Brown's Ferry-3 and Crystal River-3 have demonstrated that previously unidentified system interdependencies can be important to safety. A major aspect of these events was dependent faults (common cause/mode failures). The term systems interactions has been introduced by the Nuclear Regulatory Commission (NRC) to identify the concepts of spatial and functional coupling of systems which can lead to system interdependencies. Spatial coupling refers to dependencies resulting from a shared environmental condition; functional coupling refers to both dependencies resulting from components shared between safety and/or support systems, and to dependencies involving human actions. The NRC is currently developing guidelines to search for and evaluate adverse systems interactions at light water reactors. One approach utilizes graph theoretical methods and is called digraph matrix analysis (DMA). This methodology has been specifically tuned to the systems interaction problem. The objective of this paper is to present results from two DMA applications and to contrast them with the results from more traditional fault tree approaches.

  8. Computer subroutine ISUDS accurately solves large system of simultaneous linear algebraic equations

    NASA Technical Reports Server (NTRS)

    Collier, G.

    1967-01-01

    Computer program, an Iterative Scheme Using a Direct Solution, obtains double precision accuracy using a single-precision coefficient matrix. ISUDS solves a system of equations written in matrix form as AX equals B, where A is a square non-singular coefficient matrix, X is a vector, and B is a vector.

  9. Space-Dynamically Responding Ultrasonic Matrix System

    NASA Technical Reports Server (NTRS)

    Guigne, Jacques; Yi, Hu Chun

    2008-01-01

    Space-Dynamically Responding Ultrasonic Matrix System (SpaceDRUMS) comprises a suite of hardware that enables containerless processing (samples of experimental materials can be processed without ever touching a container wall). Using a collection of 20 acoustic beam emitters, SpaceDRUMS can completely suspend a baseball-sized solid or liquid sample during combustion or heat-based synthesis. Because the samples never contact the container walls, materials can be produced in microgravity with an unparalleled quality of shape and composition. The ultimate goal of the SpaceDRUMS hardware is to assist with the development of advanced materials of a commercial quantity and quality, using the space-based experiments to guide development of manufacturing processes on Earth. T

  10. A new accurate pill recognition system using imprint information

    NASA Astrophysics Data System (ADS)

    Chen, Zhiyuan; Kamata, Sei-ichiro

    2013-12-01

    Great achievements in modern medicine benefit human beings. Also, it has brought about an explosive growth of pharmaceuticals that current in the market. In daily life, pharmaceuticals sometimes confuse people when they are found unlabeled. In this paper, we propose an automatic pill recognition technique to solve this problem. It functions mainly based on the imprint feature of the pills, which is extracted by proposed MSWT (modified stroke width transform) and described by WSC (weighted shape context). Experiments show that our proposed pill recognition method can reach an accurate rate up to 92.03% within top 5 ranks when trying to classify more than 10 thousand query pill images into around 2000 categories.

  11. Systems and methods for deactivating a matrix converter

    DOEpatents

    Ransom, Ray M.

    2013-04-02

    Systems and methods are provided for deactivating a matrix conversion module. An electrical system comprises an alternating current (AC) interface, a matrix conversion module coupled to the AC interface, an inductive element coupled between the AC interface and the matrix conversion module, and a control module. The control module is coupled to the matrix conversion module, and in response to a shutdown condition, the control module is configured to operate the matrix conversion module to deactivate the first conversion module when a magnitude of a current through the inductive element is less than a threshold value.

  12. Fast and efficient fully 3D PET image reconstruction using sparse system matrix factorization with GPU acceleration

    NASA Astrophysics Data System (ADS)

    Zhou, Jian; Qi, Jinyi

    2011-10-01

    Statistically based iterative image reconstruction has been widely used in positron emission tomography (PET) imaging. The quality of reconstructed images depends on the accuracy of the system matrix that defines the mapping from the image space to the data space. However, an accurate system matrix is often associated with high computation cost and huge storage requirement. In this paper, we present a method to address this problem using sparse matrix factorization and graphics processor unit (GPU) acceleration. We factor the accurate system matrix into three highly sparse matrices: a sinogram blurring matrix, a geometric projection matrix and an image blurring matrix. The geometrical projection matrix is precomputed based on a simple line integral model, while the sinogram and image blurring matrices are estimated from point-source measurements. The resulting factored system matrix has far less nonzero elements than the original system matrix, which substantially reduces the storage and computation cost. The smaller matrix size also allows an efficient implementation of the forward and backward projectors on a GPU, which often has a limited memory space. Our experimental studies show that the proposed method can dramatically reduce the computation cost of high-resolution iterative image reconstruction, while achieving better performance than existing factorization methods.

  13. System matrix modelling of externally tracked motion

    PubMed Central

    Rahmim, Arman; Cheng, Ju-Chieh; Dinelle, Katie; Shilov, Mikhail; Segars, W. Paul; Rousset, Olivier G.; Tsui, Benjamin M.W.; Wong, Dean F.; Sossi, Vesna

    2010-01-01

    Background and aim In high-resolution emission tomography imaging, even small patient movements can considerably degrade image quality. The aim of this work was to develop a general approach to motion-corrected reconstruction of motion-contaminated data in the case of rigid motion (particularly brain imaging) which would be applicable to any PET scanner in the field, without specialized data-acquisition requirements. Methods Assuming the ability to externally track subject motion during scanning (e.g., using the Polaris camera), we proposed to incorporate the measured rigid motion information into the system matrix of the expectation maximization reconstruction algorithm. Furthermore, we noted and developed a framework to incorporate the additional effect of motion on modifying the attenuation factors. A new mathematical brain phantom was developed and used along with elaborate combined Simset/GATE simulations to compare the proposed framework with the cases of no motion correction. Results and conclusion Clear qualitative and quantitative improvements were observed when incorporating the proposed framework. The method is very practical to implement for any scanner in the field, not requiring any hardware modifications or access to the list-mode acquisition capability. PMID:18458606

  14. An accurate continuous calibration system for high voltage current transformer

    NASA Astrophysics Data System (ADS)

    Tong, Yue; Li, Bin Hong

    2011-02-01

    A continuous calibration system for high voltage current transformers is presented in this paper. The sensor of this system is based on a kind of electronic instrument current transformer, which is a clamp-shape air core coil. This system uses an optical fiber transmission system for its signal transmission and power supply. Finally the digital integrator and fourth-order convolution window algorithm as error calculation methods are realized by the virtual instrument with a personal computer. It is found that this system can calibrate a high voltage current transformer while energized, which means avoiding a long calibrating period in the power system and the loss of power metering expense. At the same time, it has a wide dynamic range and frequency band, and it can achieve a high accuracy measurement in a complex electromagnetic field environment. The experimental results and the on-site operation results presented in the last part of the paper, prove that it can reach the 0.05 accuracy class and is easy to operate on site.

  15. Accurate aircraft wind measurements using the global positioning system (GPS)

    SciTech Connect

    Dobosy, R.J.; Crawford, T.L., McMillen, R.T., Dumas, E.J.

    1996-11-01

    High accuracy measurements of the spatial distribution of wind speed are required in the study of turbulent exchange between the atmosphere and the earth. The use of a differential global positioning system (GPS) to determine the sensor velocity vector component of wind speed is discussed in this paper. The results of noise and rocking testing are summarized, and fluxes obtained from the GPS-based methods are compared to those measured from systems on towers and airplanes. The GPS-based methods provided usable measurements that compared well with tower and aircraft data at a significantly lower cost. 21 refs., 1 fig., 2 tabs.

  16. Micron-Accurate Laser Fresnel-Diffraction Ranging System

    NASA Technical Reports Server (NTRS)

    Lehner, David; Campbell, Jonathan; Smith, Kelly; Sanders, Alvin; Allison, Stephen; Smaley, Larry

    2008-01-01

    Two versions of an optoelectronic system undergoing development are depicted. The system is expected to be capable of measuring a distance between 2 and 10 m with an error of no more than 1 micrometer. The system would be designed to exploit Fresnel diffraction of a laser beam. In particular, it would be designed to take advantage of the fact that a Fresnel diffraction pattern is ultrasensitive to distance. The two versions would differ in the following respects: In version 1, the focus of the telescope would be in the Fresnel region, and the telescope would have a small depth of focus. As a consequence, the Fresnel pattern would be imaged directly onto the photodetector array; in version 2, a multielement lens module would displace the Fresnel region from the vicinity of the pinhole to the vicinity of the optical receiver. As the distance to be measured varied, the location of the receiver relative to the displaced Fresnel-diffraction region would vary, thereby causing the Fresnel diffraction pattern on the focal plane to vary. The multielement lens module would also correct for aberrations. The processing of the digitized Fresnel diffraction pattern in the computer might be accelerated by using only parts of the pattern or even only one small part - the central pixel. As the distance from the pinhole increased, the central pixel would rapidly cycle between maximum and minimum light intensity. This in itself would not be sufficient to uniquely determine the distance. However, by varying the size of the pinhole or the wavelength of the laser, one could obtain a second cycle of variation of intensity that, in conjunction with the first cycle, could enable a unique determination of distance. Alternatively, for a single wavelength and a single pinhole size, it should suffice to consider the data from only two different key pixels in the Fresnel pattern.

  17. Developing accurate molecular mechanics force fields for conjugated molecular systems.

    PubMed

    Do, Hainam; Troisi, Alessandro

    2015-10-14

    A rapid method to parameterize the intramolecular component of classical force fields for complex conjugated molecules is proposed. The method is based on a procedure of force matching with a reference electronic structure calculation. It is particularly suitable for those applications where molecular dynamics simulations are used to generate structures that are therefore analysed by electronic structure methods, because it is possible to build force fields that are consistent with electronic structure calculations that follow classical simulations. Such applications are commonly encountered in organic electronics, spectroscopy of complex systems and photobiology (e.g. photosynthetic systems). We illustrate the method by parameterizing the force fields of a molecule used in molecular semiconductors (2,2-dicyanovinyl-capped S,N-heteropentacene or DCV-SN5), a polymeric semiconductor (thieno[3,2-b]thiophene-diketopyrrolopyrrole TT-DPP) and a chromophore embedded in a protein environment (15,16-dihydrobiliverdin or DBV) where several hundreds of parameters need to be optimized in parallel.

  18. Blood-Pressure Measuring System Gives Accurate Graphic Output

    NASA Technical Reports Server (NTRS)

    1965-01-01

    The problem: To develop an instrument that will provide an external (indirect) measurement of arterial blood pressure in the form of an easily interpreted graphic trace that can be correlated with standard clinical blood-pressure measurements. From sphygmograms produced by conventional sphygmographs, it is very difficult to differentiate the systolic and diastolic blood-pressure pulses and to correlate these indices with the standard clinical values. It is nearly impossible to determine these indices when the subject is under physical or emotional stress. The solution: An electronic blood-pressure system, basically similar to conventional ausculatory sphygmomanometers, employing a standard occluding cuff, a gas-pressure source, and a gas-pressure regulator and valve. An electrical output transducer senses cuff pressure, and a microphone positioned on the brachial artery under the occluding cuff monitors the Korotkoff sounds from this artery. The output signals present the conventional systolic and diastolic indices in a clear, graphical display. The complete system also includes an electronic timer and cycle-control circuit.

  19. Polymer Matrix Composites for Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Nettles, Alan T.

    2003-01-01

    The Access-to-Space study identified the requirement for lightweight structures to achieve orbit with a single-stage vehicle. Thus a task was undertaken to examine the use of polymer matrix composites for propulsion components. It was determined that the effort of this task would be to extend previous efforts with polymer matrix composite feedlines and demonstrate the feasibility of manufacturing large diameter feedlines with a complex shape and integral flanges, (i.e. all one piece with a 90 deg bend), and assess their performance under a cryogenic atmosphere.

  20. The Development of a Digital Processing System for Accurate Range Determinations. [for Teleoperator Maneuvering Systems

    NASA Technical Reports Server (NTRS)

    Pujol, A., Jr.

    1983-01-01

    The development of an accurate close range (from 0.0 meters to 30.0 meters) radar system for Teleoperator Maneuvering Systems (TMS) is discussed. The system under investigation is a digital processor that converts incoming signals from the radar system into their related frequency spectra. Identification will be attempted by correlating spectral characteristics with accurate range determinataions. The system will utilize an analog to digital converter for sampling and converting the signal from the radar system into 16-bit digital words (two bytes) for RAM storage, data manipulations, and computations. To remove unwanted frequency components the data will be retrieved from RAM and digitally filtered using large scale integration (LSI) circuits. Filtering will be performed by a biquadratic routine within the chip which carries out the required filter algorithm. For conversion to a frequency spectrum the filtered data will be processed by a Fast Fourier Transform chip. Analysis and identification of spectral characteristics for accurate range determinations will be made by microcomputer computations.

  1. Application of transmissibility matrix and random matrix to Bayesian system identification with response measurements only

    NASA Astrophysics Data System (ADS)

    Yan, Wang-Ji; Katafygiotis, Lambros S.

    2016-10-01

    The problem of stochastic system identification utilizing response measurements only is considered in this paper. A negative log-likelihood function utilized to determine the posterior most probable parameters and their associated uncertainties is formulated by incorporating transmissibility matrix concept, random matrix theory and Bayes’ theorem. A numerically iterative coupled method involving the optimization of the parameters in groups is proposed so as to reduce the dimension of the numerical optimization problem involved. The initial guess for the parameters to be optimized is also properly estimated through asymptotic analysis. One novel feature of the proposed method is to avoid repeated time-consuming evaluation of the determinant and inverse of the covariance matrix during optimization due to exploring the statistical properties of the trace of Wishart matrix. The proposed method requires no information about the model of the external input. The theory described in this work is illustrated with synthetic data and field data measured from a laboratory model installed with wireless sensors.

  2. Advanced fiber/matrix material systems

    NASA Technical Reports Server (NTRS)

    Hartness, J. Timothy

    1991-01-01

    Work completed in Phase 1 of the NASA Advanced Composite Technology program is discussed. Two towpreg forms (commingled yarns and fused powder towpregs) are being characterized under the program. These towpregs will be used to evaluate textile fabrication technologies for advanced aircraft composite structures. The unique characteristic of both of these material forms is that both fiber and matrix resin are handled in a single operation such as weaving, braiding, or fiber placement. The evaluation of both commingled and fused powder towpreg is described. Various polymer materials are considered for both subsonic and supersonic applications. Polymers initially being evaluated include thermoplastic polyimides such as Larc-TPI and New-TPI, thermoplastics such as PEEK and PEKEKK as well as some toughened crosslinked polyimides. Preliminary mechanical properties as well as tow handling are evaluated.

  3. Filler/ Polycarbosilane Systems as CMC Matrix Precursors

    NASA Technical Reports Server (NTRS)

    Hurwitz, Frances I.

    1998-01-01

    Pyrolytic conversion of polymeric precursors to ceramics is accompanied by loss of volatiles and large volume changes. Infiltration of a low viscosity polymer into a fiber preform will fill small spaces within fiber tows by capillary forces, but create large matrix cracks within large, intertow areas. One approach to minimizing shrinkage and reducing the number of required infiltration cycles is to use particulate fillers. In this study, Starfire allylhydridopolycarbosilane (AHPCS) was blended with a silicon carbide powder, with and without dispersant, using shear mixing. The polymer and polymer/particle interactions were characterized using nuclear magnetic resonance, differential scanning calorimetry, thermogravimetric analysis and rheometry. Polymer/particulate slurries and suspensions were used to infiltrate a figidized preform of an eight ply five harness satin CG Nicalon fiber having a dual layer BN/SiC interface coating, and the resulting composites characterized by optical and scanning electron microscopy.

  4. Open quantum systems and random matrix theory

    SciTech Connect

    Mulhall, Declan

    2014-10-15

    A simple model for open quantum systems is analyzed with RMT. The system is coupled to the continuum in a minimal way. In this paper we see the effect of opening the system on the level statistics, in particular the level spacing, width distribution and Δ{sub 3}(L) statistic are examined as a function of the strength of this coupling. The usual super-radiant state is observed, and it is seen that as it is formed, the level spacing and Δ{sub 3}(L) statistic exhibit the signatures of missed levels.

  5. Generalized Mueller matrix method for polarization mode dispersion measurement in a system with polarization-dependent loss or gain.

    PubMed

    Dong, H; Shum, P; Yan, M; Zhou, J Q; Ning, G X; Gong, Y D; Wu, C Q

    2006-06-12

    A generalized Mueller matrix method (GMMM) is proposed to measure the polarization mode dispersion (PMD) in an optical fiber system with polarization-dependent loss or gain (PDL/G). This algorithm is based on the polar decomposition of a 4X4 matrix which corresponds to a Lorentz transformation. Compared to the generalized Poincaré sphere method, the GMMM can measure PMD accurately with a relatively larger frequency step, and the obtained PMD data has very low noise level. PMID:19516669

  6. RF system calibration for global Q matrix determination

    PubMed Central

    Padormo, Francesco; Beqiri, Arian; Malik, Shaihan J.; Hajnal, Joseph V.

    2016-01-01

    The use of multiple transmission channels (known as Parallel Transmission, or PTx) provides increased control of the MRI signal formation process. This extra flexibility comes at a cost of uncertainty of the power deposited in the patient under examination: the electric fields produced by each transmitter can interfere in such a way to lead to excessively high heating. Although it is not possible to determine local heating, the global Q matrix (which allows the whole-body Specific Absorption Rate (SAR) to be known for any PTx pulse) can be measured in-situ by monitoring the power incident upon and reflected by each transmit element during transmission. Recent observations have shown that measured global Q matrices can be corrupted by losses between the coil array and location of power measurement. In this work we demonstrate that these losses can be accounted for, allowing accurate global Q matrix measurement independent of the location of the power measurement devices. PMID:26747407

  7. Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems

    PubMed Central

    Price, Nathan D; Joyce, Andrew R; Palsson, Bernhard O

    2006-01-01

    Complex regulatory networks control the transcription state of a genome. These transcriptional regulatory networks (TRNs) have been mathematically described using a Boolean formalism, in which the state of a gene is represented as either transcribed or not transcribed in response to regulatory signals. The Boolean formalism results in a series of regulatory rules for the individual genes of a TRN that in turn can be used to link environmental cues to the transcription state of a genome, thereby forming a complete transcriptional regulatory system (TRS). Herein, we develop a formalism that represents such a set of regulatory rules in a matrix form. Matrix formalism allows for the systemic characterization of the properties of a TRS and facilitates the computation of the transcriptional state of the genome under any given set of environmental conditions. Additionally, it provides a means to incorporate mechanistic detail of a TRS as it becomes available. In this study, the regulatory network matrix, R, for a prototypic TRS is characterized and the fundamental subspaces of this matrix are described. We illustrate how the matrix representation of a TRS coupled with its environment (R*) allows for a sampling of all possible expression states of a given network, and furthermore, how the fundamental subspaces of the matrix provide a way to study key TRS features and may assist in experimental design. PMID:16895435

  8. Transfer matrix analysis of backscattering and reflection effects on WDM-PON systems.

    PubMed

    Simatupang, Joni Welman; Lee, San-Liang

    2013-11-18

    This paper proposes using power transfer matrix analysis to characterize the effects of Rayleigh backscattering and Fresnel reflection on WDM-PON systems. The modeling of a WDM-PON system can be carried out simply by matrix multiplication of the corresponding matrices for all the building blocks, where all possible guided backward lights and resonant configurations along the optical network can be accounted for. The total sum of all interferences affecting the bidirectional transmission that leads to an optical crosstalk-to-signal (C/S) ratio can be modeled as back-reflections through cascaded two-port networks for the downstream and upstream signals. This approach is simple, robust, efficient, and also accurate. Its accuracy is verified for simple system architectures and then applied to study more complicated cases. The results show its versatility to analyze a wide variety of bidirectional optical transmission systems.

  9. Top Event Matrix Analysis Code System.

    2000-06-19

    Version 00 TEMAC is designed to permit the user to easily estimate risk and to perform sensitivity and uncertainty analyses with a Boolean expression such as produced by the SETS computer program. SETS produces a mathematical representation of a fault tree used to model system unavailability. In the terminology of the TEMAC program, such a mathematical representation is referred to as a top event. The analysis of risk involves the estimation of the magnitude ofmore » risk, the sensitivity of risk estimates to base event probabilities and initiating event frequencies, and the quantification of the uncertainty in the risk estimates.« less

  10. The performance of a hybrid analytical-Monte Carlo system response matrix in pinhole SPECT reconstruction.

    PubMed

    El Bitar, Z; Pino, F; Candela, C; Ros, D; Pavía, J; Rannou, F R; Ruibal, A; Aguiar, P

    2014-12-21

    It is well-known that in pinhole SPECT (single-photon-emission computed tomography), iterative reconstruction methods including accurate estimations of the system response matrix can lead to submillimeter spatial resolution. There are two different methods for obtaining the system response matrix: those that model the system analytically using an approach including an experimental characterization of the detector response, and those that make use of Monte Carlo simulations. Methods based on analytical approaches are faster and handle the statistical noise better than those based on Monte Carlo simulations, but they require tedious experimental measurements of the detector response. One suggested approach for avoiding an experimental characterization, circumventing the problem of statistical noise introduced by Monte Carlo simulations, is to perform an analytical computation of the system response matrix combined with a Monte Carlo characterization of the detector response. Our findings showed that this approach can achieve high spatial resolution similar to that obtained when the system response matrix computation includes an experimental characterization. Furthermore, we have shown that using simulated detector responses has the advantage of yielding a precise estimate of the shift between the point of entry of the photon beam into the detector and the point of interaction inside the detector. Considering this, it was possible to slightly improve the spatial resolution in the edge of the field of view.

  11. Conditional random matrix ensembles and the stability of dynamical systems

    NASA Astrophysics Data System (ADS)

    Kirk, Paul; Rolando, Delphine M. Y.; MacLean, Adam L.; Stumpf, Michael P. H.

    2015-08-01

    Random matrix theory (RMT) has found applications throughout physics and applied mathematics, in subject areas as diverse as communications networks, population dynamics, neuroscience, and models of the banking system. Many of these analyses exploit elegant analytical results, particularly the circular law and its extensions. In order to apply these results, assumptions must be made about the distribution of matrix elements. Here we demonstrate that the choice of matrix distribution is crucial. In particular, adopting an unrealistic matrix distribution for the sake of analytical tractability is liable to lead to misleading conclusions. We focus on the application of RMT to the long-standing, and at times fractious, ‘diversity-stability debate’, which is concerned with establishing whether large complex systems are likely to be stable. Early work (and subsequent elaborations) brought RMT to bear on the debate by modelling the entries of a system’s Jacobian matrix as independent and identically distributed (i.i.d.) random variables. These analyses were successful in yielding general results that were not tied to any specific system, but relied upon a restrictive i.i.d. assumption. Other studies took an opposing approach, seeking to elucidate general principles of stability through the analysis of specific systems. Here we develop a statistical framework that reconciles these two contrasting approaches. We use a range of illustrative dynamical systems examples to demonstrate that: (i) stability probability cannot be summarily deduced from any single property of the system (e.g. its diversity); and (ii) our assessment of stability depends on adequately capturing the details of the systems analysed. Failing to condition on the structure of dynamical systems will skew our analysis and can, even for very small systems, result in an unnecessarily pessimistic diagnosis of their stability.

  12. Sparse matrix approximation method for an active optical control system

    NASA Astrophysics Data System (ADS)

    Murphy, Timothy P.; Lyon, Richard G.; Dorband, John E.; Hollis, Jan M.

    2001-12-01

    We develop a sparse matrix approximation method to decompose a wave front into a basis set of actuator influence functions for an active optical system consisting of a deformable mirror and a segmented primary mirror. The wave front used is constructed by Zernike polynomials to simulate the output of a phase-retrieval algorithm. Results of a Monte Carlo simulation of the optical control loop are compared with the standard, nonsparse approach in terms of accuracy and precision, as well as computational speed and memory. The sparse matrix approximation method can yield more than a 50-fold increase in the speed and a 20-fold-reduction in matrix size and a commensurate decrease in required memory, with less than 10% degradation in solution accuracy. Our method is also shown to be better than when elements are selected for the sparse matrix on a magnitude basis alone. We show that the method developed is a viable alternative to use of the full control matrix in a phase-retrieval-based active optical control system.

  13. Sparse matrix approximation method for an active optical control system.

    PubMed

    Murphy, T P; Lyon, R G; Dorband, J E; Hollis, J M

    2001-12-10

    We develop a sparse matrix approximation method to decompose a wave front into a basis set of actuator influence functions for an active optical system consisting of a deformable mirror and a segmented primary mirror. The wave front used is constructed by Zernike polynomials to simulate the output of a phase-retrieval algorithm. Results of a Monte Carlo simulation of the optical control loop are compared with the standard, nonsparse approach in terms of accuracy and precision, as well as computational speed and memory. The sparse matrix approximation method can yield more than a 50-fold increase in the speed and a 20-fold reduction in matrix size and a commensurate decrease in required memory, with less than 10% degradation in solution accuracy. Our method is also shown to be better than when elements are selected for the sparse matrix on a magnitude basis alone. We show that the method developed is a viable alternative to use of the full control matrix in a phase-retrieval-based active optical control system. PMID:18364958

  14. Using an Educational Electronic Documentation System to Help Nursing Students Accurately Identify Nursing Diagnoses

    ERIC Educational Resources Information Center

    Pobocik, Tamara J.

    2013-01-01

    The use of technology and electronic medical records in healthcare has exponentially increased. This quantitative research project used a pretest/posttest design, and reviewed how an educational electronic documentation system helped nursing students to identify the accurate related to statement of the nursing diagnosis for the patient in the case…

  15. Development of an XYZ Digital Camera with Embedded Color Calibration System for Accurate Color Acquisition

    NASA Astrophysics Data System (ADS)

    Kretkowski, Maciej; Jablonski, Ryszard; Shimodaira, Yoshifumi

    Acquisition of accurate colors is important in the modern era of widespread exchange of electronic multimedia. The variety of device-dependent color spaces causes troubles with accurate color reproduction. In this paper we present the outlines of accomplished digital camera system with device-independent output formed from tristimulus XYZ values. The outstanding accuracy and fidelity of acquired color is achieved in our system by employing an embedded color calibration system based on emissive device generating reference calibration colors with user-defined spectral distribution and chromaticity coordinates. The system was tested by calibrating the camera using 24 reference colors spectrally reproduced from 24 color patches of the Macbeth Chart. The average color difference (CIEDE2000) has been found to be ΔE =0.83, which is an outstanding result compared to commercially available digital cameras.

  16. Accurate GPS Time-Linked data Acquisition System (ATLAS II) user's manual.

    SciTech Connect

    Jones, Perry L.; Zayas, Jose R.; Ortiz-Moyet, Juan

    2004-02-01

    The Accurate Time-Linked data Acquisition System (ATLAS II) is a small, lightweight, time-synchronized, robust data acquisition system that is capable of acquiring simultaneous long-term time-series data from both a wind turbine rotor and ground-based instrumentation. This document is a user's manual for the ATLAS II hardware and software. It describes the hardware and software components of ATLAS II, and explains how to install and execute the software.

  17. A simple and accurate SNP scoring strategy based on typeIIS restriction endonuclease cleavage and matrix-assisted laser desorption/ionization mass spectrometry

    PubMed Central

    Hong, Sun Pyo; Ji, Seung Il; Rhee, Hwanseok; Shin, Soo Kyeong; Hwang, Sun Young; Lee, Seung Hwan; Lee, Soong Deok; Oh, Heung-Bum; Yoo, Wangdon; Kim, Soo-Ok

    2008-01-01

    Background We describe the development of a novel matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF)-based single nucleotide polymorphism (SNP) scoring strategy, termed Restriction Fragment Mass Polymorphism (RFMP) that is suitable for genotyping variations in a simple, accurate, and high-throughput manner. The assay is based on polymerase chain reaction (PCR) amplification and mass measurement of oligonucleotides containing a polymorphic base, to which a typeIIS restriction endonuclease recognition was introduced by PCR amplification. Enzymatic cleavage of the products leads to excision of oligonucleotide fragments representing base variation of the polymorphic site whose masses were determined by MALDI-TOF MS. Results The assay represents an improvement over previous methods because it relies on the direct mass determination of PCR products rather than on an indirect analysis, where a base-extended or fluorescent report tag is interpreted. The RFMP strategy is simple and straightforward, requiring one restriction digestion reaction following target amplification in a single vessel. With this technology, genotypes are generated with a high call rate (99.6%) and high accuracy (99.8%) as determined by independent sequencing. Conclusion The simplicity, accuracy and amenability to high-throughput screening analysis should make the RFMP assay suitable for large-scale genotype association study as well as clinical genotyping in laboratories. PMID:18538037

  18. Hydrogels Derived from Central Nervous System Extracellular Matrix

    PubMed Central

    Medberry, Christopher J.; Crapo, Peter M.; Siu, Bernard F.; Carruthers, Christopher A.; Wolf, Matthew T.; Nagarkar, Shailesh P.; Agrawal, Vineet; Jones, Kristen E.; Kelly, Jeremy; Johnson, Scott A.; Velankar, Sachin S.; Watkins, Simon C.; Modo, Michel

    2012-01-01

    Biologic scaffolds composed of extracellular matrix (ECM) are commonly used repair devices in preclinical and clinical settings; however the use of these scaffolds for peripheral and central nervous system (CNS) repair has been limited. Biologic scaffolds developed from brain and spinal cord tissue have recently been described, yet the conformation of the harvested ECM limits therapeutic utility. An injectable CNS-ECM derived hydrogel capable of in vivo polymerization and conformation to irregular lesion geometries may aid in tissue reconstruction efforts following complex neurologic trauma. The objectives of the present study were to develop hydrogel forms of brain and spinal cord ECM and compare the resulting biochemical composition, mechanical properties, and neurotrophic potential of a brain derived cell line to a non-CNS-ECM hydrogel, urinary bladder matrix. Results showed distinct differences between compositions of brain ECM, spinal cord ECM, and urinary bladder matrix. The rheologic modulus of spinal cord ECM hydrogel was greater than that of brain ECM and urinary bladder matrix. All ECMs increased the number of cells expressing neurites, but only brain ECM increased neurite length, suggesting a possible tissue-specific effect. All hydrogels promoted three-dimensional uni- or bi-polar neurite outgrowth following 7 days in culture. These results suggest that CNS-ECM hydrogels may provide supportive scaffolding to promote in vivo axonal repair. PMID:23158935

  19. Enzyme system comprising an enzyme bonded in a porous matrix

    DOEpatents

    Ackerman, Eric [Richland, WA; Liu, Jun [West Richland, WA

    2010-12-07

    A protein system is described in which a protein is bound within a matrix material that has pores that are sized to achieve excellent properties such as: activity, protein density, and stability. In a preferred embodiment, the pore sizes range from 50 to 400 .ANG.. One protein that has demonstrated surprisingly good results in this system is OPH. This protein is known to degrade organophosphorus compounds such as are found in chemical weapons and pesticides. Novel methods of forming the protein system and methods of making OPH are also described.

  20. Interactive display system having a matrix optical detector

    DOEpatents

    Veligdan, James T.; DeSanto, Leonard

    2007-01-23

    A display system includes a waveguide optical panel having an inlet face and an opposite outlet face. An image beam is projected across the inlet face laterally and transversely for display on the outlet face. An optical detector including a matrix of detector elements is optically aligned with the inlet face for detecting a corresponding lateral and transverse position of an inbound light spot on the outlet face.

  1. Accurate analysis of blood vessel sizes and stenotic lesions using stereoscopic DSA system.

    PubMed

    Fencil, L E; Doi, K; Hoffman, K R

    1988-01-01

    We have developed a technique to determine accurately the magnification factor and three-dimensional orientation of a vessel segment from a stereoscopic pair of digital subtraction angiograms (DSA). Our DSA system includes a stereoscopic x-ray tube with a 25-mm focal spot shift. The magnification and orientation of a selected vessel segment are determined from the distance and direction of the focal spot shift and the stereoscopic discrepancy in image positions for that segment. Our results indicate that the accuracies of determining the magnification and orientation are less than 1% and approximately 5 degrees, respectively. After the magnification and orientation are determined accurately, an iterative deconvolution technique for the measurement of vessel image size is applied to the selected vessel segment. This iterative deconvolution technique provides the best estimate of vessel image size by taking into account the unsharpness of the digital system. With this technique, the vessel image size can be determined to an accuracy of approximately 1.0 mm, which corresponds to one third the pixel size of our DSA system. Information derived from stereoscopic analysis and iterative deconvolution thus allows accurate calculation of actual vascular dimensions from DSA images.

  2. Highly accurate and fast optical penetration-based silkworm gender separation system

    NASA Astrophysics Data System (ADS)

    Kamtongdee, Chakkrit; Sumriddetchkajorn, Sarun; Chanhorm, Sataporn

    2015-07-01

    Based on our research work in the last five years, this paper highlights our innovative optical sensing system that can identify and separate silkworm gender highly suitable for sericulture industry. The key idea relies on our proposed optical penetration concepts and once combined with simple image processing operations leads to high accuracy in identifying of silkworm gender. Inside the system, there are electronic and mechanical parts that assist in controlling the overall system operation, processing the optical signal, and separating the female from male silkworm pupae. With current system performance, we achieve a very highly accurate more than 95% in identifying gender of silkworm pupae with an average system operational speed of 30 silkworm pupae/minute. Three of our systems are already in operation at Thailand's Queen Sirikit Sericulture Centers.

  3. Efficient methodologies for system matrix modelling in iterative image reconstruction for rotating high-resolution PET

    NASA Astrophysics Data System (ADS)

    Ortuño, J. E.; Kontaxakis, G.; Rubio, J. L.; Guerra, P.; Santos, A.

    2010-04-01

    A fully 3D iterative image reconstruction algorithm has been developed for high-resolution PET cameras composed of pixelated scintillator crystal arrays and rotating planar detectors, based on the ordered subsets approach. The associated system matrix is precalculated with Monte Carlo methods that incorporate physical effects not included in analytical models, such as positron range effects and interaction of the incident gammas with the scintillator material. Custom Monte Carlo methodologies have been developed and optimized for modelling of system matrices for fast iterative image reconstruction adapted to specific scanner geometries, without redundant calculations. According to the methodology proposed here, only one-eighth of the voxels within two central transaxial slices need to be modelled in detail. The rest of the system matrix elements can be obtained with the aid of axial symmetries and redundancies, as well as in-plane symmetries within transaxial slices. Sparse matrix techniques for the non-zero system matrix elements are employed, allowing for fast execution of the image reconstruction process. This 3D image reconstruction scheme has been compared in terms of image quality to a 2D fast implementation of the OSEM algorithm combined with Fourier rebinning approaches. This work confirms the superiority of fully 3D OSEM in terms of spatial resolution, contrast recovery and noise reduction as compared to conventional 2D approaches based on rebinning schemes. At the same time it demonstrates that fully 3D methodologies can be efficiently applied to the image reconstruction problem for high-resolution rotational PET cameras by applying accurate pre-calculated system models and taking advantage of the system's symmetries.

  4. Sparse matrix methods research using the CSM testbed software system

    NASA Technical Reports Server (NTRS)

    Chu, Eleanor; George, J. Alan

    1989-01-01

    Research is described on sparse matrix techniques for the Computational Structural Mechanics (CSM) Testbed. The primary objective was to compare the performance of state-of-the-art techniques for solving sparse systems with those that are currently available in the CSM Testbed. Thus, one of the first tasks was to become familiar with the structure of the testbed, and to install some or all of the SPARSPAK package in the testbed. A suite of subroutines to extract from the data base the relevant structural and numerical information about the matrix equations was written, and all the demonstration problems distributed with the testbed were successfully solved. These codes were documented, and performance studies comparing the SPARSPAK technology to the methods currently in the testbed were completed. In addition, some preliminary studies were done comparing some recently developed out-of-core techniques with the performance of the testbed processor INV.

  5. Decoherence in chaotic and integrable systems: a random matrix approach

    NASA Astrophysics Data System (ADS)

    Gorin, T.; Seligman, T. H.

    2003-03-01

    We study the influence of chaos and order on entanglement and decoherence. In view of applications in quantum computing and teleportation which should be able to work with arbitrarily complicated states, we pay particular attention to the behavior of random states. While studies with coherent states indicate that chaos accelerates decoherence and entanglement, we find that there is practically no difference between the chaotic and the integrable case, as far as random states are concerned. In the present studies we use unitary time evolution of the total system, and partial traces to emulate decoherence. Random matrix models are a natural choice to describe the dynamics of random states. The invariant aspects of chaos and order are then reflected in the different spectral statistics. We develop random matrix models for the evolution of entanglement for a large variety of situations, discussing the strong coupling case in full detail.

  6. Enhanced Constraints for Accurate Lower Bounds on Many-Electron Quantum Energies from Variational Two-Electron Reduced Density Matrix Theory

    NASA Astrophysics Data System (ADS)

    Mazziotti, David A.

    2016-10-01

    A central challenge of physics is the computation of strongly correlated quantum systems. The past ten years have witnessed the development and application of the variational calculation of the two-electron reduced density matrix (2-RDM) without the wave function. In this Letter we present an orders-of-magnitude improvement in the accuracy of 2-RDM calculations without an increase in their computational cost. The advance is based on a low-rank, dual formulation of an important constraint on the 2-RDM, the T 2 condition. Calculations are presented for metallic chains and a cadmium-selenide dimer. The low-scaling T 2 condition will have significant applications in atomic and molecular, condensed-matter, and nuclear physics.

  7. Development of an accurate transmission line fault locator using the global positioning system satellites

    NASA Technical Reports Server (NTRS)

    Lee, Harry

    1994-01-01

    A highly accurate transmission line fault locator based on the traveling-wave principle was developed and successfully operated within B.C. Hydro. A transmission line fault produces a fast-risetime traveling wave at the fault point which propagates along the transmission line. This fault locator system consists of traveling wave detectors located at key substations which detect and time tag the leading edge of the fault-generated traveling wave as if passes through. A master station gathers the time-tagged information from the remote detectors and determines the location of the fault. Precise time is a key element to the success of this system. This fault locator system derives its timing from the Global Positioning System (GPS) satellites. System tests confirmed the accuracy of locating faults to within the design objective of +/-300 meters.

  8. Accurate Vehicle Location System Using RFID, an Internet of Things Approach.

    PubMed

    Prinsloo, Jaco; Malekian, Reza

    2016-06-04

    Modern infrastructure, such as dense urban areas and underground tunnels, can effectively block all GPS signals, which implies that effective position triangulation will not be achieved. The main problem that is addressed in this project is the design and implementation of an accurate vehicle location system using radio-frequency identification (RFID) technology in combination with GPS and the Global system for Mobile communication (GSM) technology, in order to provide a solution to the limitation discussed above. In essence, autonomous vehicle tracking will be facilitated with the use of RFID technology where GPS signals are non-existent. The design of the system and the results are reflected in this paper. An extensive literature study was done on the field known as the Internet of Things, as well as various topics that covered the integration of independent technology in order to address a specific challenge. The proposed system is then designed and implemented. An RFID transponder was successfully designed and a read range of approximately 31 cm was obtained in the low frequency communication range (125 kHz to 134 kHz). The proposed system was designed, implemented, and field tested and it was found that a vehicle could be accurately located and tracked. It is also found that the antenna size of both the RFID reader unit and RFID transponder plays a critical role in the maximum communication range that can be achieved.

  9. Accurate Vehicle Location System Using RFID, an Internet of Things Approach.

    PubMed

    Prinsloo, Jaco; Malekian, Reza

    2016-01-01

    Modern infrastructure, such as dense urban areas and underground tunnels, can effectively block all GPS signals, which implies that effective position triangulation will not be achieved. The main problem that is addressed in this project is the design and implementation of an accurate vehicle location system using radio-frequency identification (RFID) technology in combination with GPS and the Global system for Mobile communication (GSM) technology, in order to provide a solution to the limitation discussed above. In essence, autonomous vehicle tracking will be facilitated with the use of RFID technology where GPS signals are non-existent. The design of the system and the results are reflected in this paper. An extensive literature study was done on the field known as the Internet of Things, as well as various topics that covered the integration of independent technology in order to address a specific challenge. The proposed system is then designed and implemented. An RFID transponder was successfully designed and a read range of approximately 31 cm was obtained in the low frequency communication range (125 kHz to 134 kHz). The proposed system was designed, implemented, and field tested and it was found that a vehicle could be accurately located and tracked. It is also found that the antenna size of both the RFID reader unit and RFID transponder plays a critical role in the maximum communication range that can be achieved. PMID:27271638

  10. Accurate Vehicle Location System Using RFID, an Internet of Things Approach

    PubMed Central

    Prinsloo, Jaco; Malekian, Reza

    2016-01-01

    Modern infrastructure, such as dense urban areas and underground tunnels, can effectively block all GPS signals, which implies that effective position triangulation will not be achieved. The main problem that is addressed in this project is the design and implementation of an accurate vehicle location system using radio-frequency identification (RFID) technology in combination with GPS and the Global system for Mobile communication (GSM) technology, in order to provide a solution to the limitation discussed above. In essence, autonomous vehicle tracking will be facilitated with the use of RFID technology where GPS signals are non-existent. The design of the system and the results are reflected in this paper. An extensive literature study was done on the field known as the Internet of Things, as well as various topics that covered the integration of independent technology in order to address a specific challenge. The proposed system is then designed and implemented. An RFID transponder was successfully designed and a read range of approximately 31 cm was obtained in the low frequency communication range (125 kHz to 134 kHz). The proposed system was designed, implemented, and field tested and it was found that a vehicle could be accurately located and tracked. It is also found that the antenna size of both the RFID reader unit and RFID transponder plays a critical role in the maximum communication range that can be achieved. PMID:27271638

  11. Prometheus: Scalable and Accurate Emulation of Task-Based Applications on Many-Core Systems.

    SciTech Connect

    Kestor, Gokcen; Gioiosa, Roberto; Chavarría-Miranda, Daniel

    2015-03-01

    Modeling the performance of non-deterministic parallel applications on future many-core systems requires the development of novel simulation and emulation techniques and tools. We present “Prometheus”, a fast, accurate and modular emulation framework for task-based applications. By raising the level of abstraction and focusing on runtime synchronization, Prometheus can accurately predict applications’ performance on very large many-core systems. We validate our emulation framework against two real platforms (AMD Interlagos and Intel MIC) and report error rates generally below 4%. We, then, evaluate Prometheus’ performance and scalability: our results show that Prometheus can emulate a task-based application on a system with 512K cores in 11.5 hours. We present two test cases that show how Prometheus can be used to study the performance and behavior of systems that present some of the characteristics expected from exascale supercomputer nodes, such as active power management and processors with a high number of cores but reduced cache per core.

  12. Method for analysis of the characteristic matrix in optical systems

    SciTech Connect

    Craig, R.A.

    1987-06-01

    Similarity between the characteristic matrix and the scattering matrix is noted. This similarity is exploited to develop a method for deriving the characteristic matrix in a closed form and to develop a perturbation expansion of the characteristic matrix of one-dimensional variation of refractive index. Examples are given.

  13. Time Accurate Unsteady Pressure Loads Simulated for the Space Launch System at a Wind Tunnel Condition

    NASA Technical Reports Server (NTRS)

    Alter, Stephen J.; Brauckmann, Gregory J.; Kleb, Bil; Streett, Craig L; Glass, Christopher E.; Schuster, David M.

    2015-01-01

    Using the Fully Unstructured Three-Dimensional (FUN3D) computational fluid dynamics code, an unsteady, time-accurate flow field about a Space Launch System configuration was simulated at a transonic wind tunnel condition (Mach = 0.9). Delayed detached eddy simulation combined with Reynolds Averaged Naiver-Stokes and a Spallart-Almaras turbulence model were employed for the simulation. Second order accurate time evolution scheme was used to simulate the flow field, with a minimum of 0.2 seconds of simulated time to as much as 1.4 seconds. Data was collected at 480 pressure taps at locations, 139 of which matched a 3% wind tunnel model, tested in the Transonic Dynamic Tunnel (TDT) facility at NASA Langley Research Center. Comparisons between computation and experiment showed agreement within 5% in terms of location for peak RMS levels, and 20% for frequency and magnitude of power spectral densities. Grid resolution and time step sensitivity studies were performed to identify methods for improved accuracy comparisons to wind tunnel data. With limited computational resources, accurate trends for reduced vibratory loads on the vehicle were observed. Exploratory methods such as determining minimized computed errors based on CFL number and sub-iterations, as well as evaluating frequency content of the unsteady pressures and evaluation of oscillatory shock structures were used in this study to enhance computational efficiency and solution accuracy. These techniques enabled development of a set of best practices, for the evaluation of future flight vehicle designs in terms of vibratory loads.

  14. Multi-ray-based system matrix generation for 3D PET reconstruction.

    PubMed

    Moehrs, Sascha; Defrise, Michel; Belcari, Nicola; Guerra, Alberto Del; Bartoli, Antonietta; Fabbri, Serena; Zanetti, Gianluigi

    2008-12-01

    Iterative image reconstruction algorithms for positron emission tomography (PET) require a sophisticated system matrix (model) of the scanner. Our aim is to set up such a model offline for the YAP-(S)PET II small animal imaging tomograph in order to use it subsequently with standard ML-EM (maximum-likelihood expectation maximization) and OSEM (ordered subset expectation maximization) for fully three-dimensional image reconstruction. In general, the system model can be obtained analytically, via measurements or via Monte Carlo simulations. In this paper, we present the multi-ray method, which can be considered as a hybrid method to set up the system model offline. It incorporates accurate analytical (geometric) considerations as well as crystal depth and crystal scatter effects. At the same time, it has the potential to model seamlessly other physical aspects such as the positron range. The proposed method is based on multiple rays which are traced from/to the detector crystals through the image volume. Such a ray-tracing approach itself is not new; however, we derive a novel mathematical formulation of the approach and investigate the positioning of the integration (ray-end) points. First, we study single system matrix entries and show that the positioning and weighting of the ray-end points according to Gaussian integration give better results compared to equally spaced integration points (trapezoidal integration), especially if only a small number of integration points (rays) are used. Additionally, we show that, for a given variance of the single matrix entries, the number of rays (events) required to calculate the whole matrix is a factor of 20 larger when using a pure Monte-Carlo-based method. Finally, we analyse the quality of the model by reconstructing phantom data from the YAP-(S)PET II scanner. PMID:19001696

  15. Multi-ray-based system matrix generation for 3D PET reconstruction

    NASA Astrophysics Data System (ADS)

    Moehrs, Sascha; Defrise, Michel; Belcari, Nicola; DelGuerra, Alberto; Bartoli, Antonietta; Fabbri, Serena; Zanetti, Gianluigi

    2008-12-01

    Iterative image reconstruction algorithms for positron emission tomography (PET) require a sophisticated system matrix (model) of the scanner. Our aim is to set up such a model offline for the YAP-(S)PET II small animal imaging tomograph in order to use it subsequently with standard ML-EM (maximum-likelihood expectation maximization) and OSEM (ordered subset expectation maximization) for fully three-dimensional image reconstruction. In general, the system model can be obtained analytically, via measurements or via Monte Carlo simulations. In this paper, we present the multi-ray method, which can be considered as a hybrid method to set up the system model offline. It incorporates accurate analytical (geometric) considerations as well as crystal depth and crystal scatter effects. At the same time, it has the potential to model seamlessly other physical aspects such as the positron range. The proposed method is based on multiple rays which are traced from/to the detector crystals through the image volume. Such a ray-tracing approach itself is not new; however, we derive a novel mathematical formulation of the approach and investigate the positioning of the integration (ray-end) points. First, we study single system matrix entries and show that the positioning and weighting of the ray-end points according to Gaussian integration give better results compared to equally spaced integration points (trapezoidal integration), especially if only a small number of integration points (rays) are used. Additionally, we show that, for a given variance of the single matrix entries, the number of rays (events) required to calculate the whole matrix is a factor of 20 larger when using a pure Monte-Carlo-based method. Finally, we analyse the quality of the model by reconstructing phantom data from the YAP-(S)PET II scanner.

  16. Monte Carlo simulation of secondary electron and backscattered electron images for a nanoparticle matrix system

    NASA Astrophysics Data System (ADS)

    Yue, Y. T.; Li, H. M.; Ding, Z. J.

    2005-06-01

    Contrast simulation of scanning electron microscope (SEM) images for particle-matrix systems is important for understanding the contrast formation mechanism in such systems. Most of the previous works have been limited to backscattered electron (BSE) signals because of the difficulties involved in the simulation of the secondary electron (SE) signals. This limitation prevents some important information from being extracted from experimental SEM images. A comprehensive and accurate Monte Carlo model has been developed for simulation of electron-solid interactions, which enables the simulation of production and emission of cascade SEs and is then quite suitable for investigating both SE and BSE signals. In this paper, we have modified the simulation model for a particle-matrix system and performed a simulation of SE and BSE images for nano-size Pt particles in a carbon matrix. Since the size of the particles is comparable with the electron scattering mean free path, modification of the conventional Monte Carlo procedure for a solid is necessary in order to include the boundary correction due to different scattering mean free paths. SE and BSE line scans and two-dimensional images under various conditions (particle size, depth and beam incident angle) are obtained and discussed in detail. The results have shown that: (1) In the formation of Pt-C contrast, the material factor plays a dominant role. (2) Only those particles located on, or quite close to, the matrix surface can be clearly revealed in a SE image. The maximum visible depth in SE observation for a Pt particle embedded in carbon matrix is about three times the particle size, while it is twice deeper than that with BSE signals. (3) The maximum SE emission from Pt particles appears at the centre of, instead of the sides of, the particle when the size falls down to the nanometre region; (4) Both the SE and BSE contrast have maximum values at a certain primary energy for particles of a specific size. (5) For

  17. A Flexible Fringe Projection Vision System with Extended Mathematical Model for Accurate Three-Dimensional Measurement

    PubMed Central

    Xiao, Suzhi; Tao, Wei; Zhao, Hui

    2016-01-01

    In order to acquire an accurate three-dimensional (3D) measurement, the traditional fringe projection technique applies complex and laborious procedures to compensate for the errors that exist in the vision system. However, the error sources in the vision system are very complex, such as lens distortion, lens defocus, and fringe pattern nonsinusoidality. Some errors cannot even be explained or rendered with clear expressions and are difficult to compensate directly as a result. In this paper, an approach is proposed that avoids the complex and laborious compensation procedure for error sources but still promises accurate 3D measurement. It is realized by the mathematical model extension technique. The parameters of the extended mathematical model for the ’phase to 3D coordinates transformation’ are derived using the least-squares parameter estimation algorithm. In addition, a phase-coding method based on a frequency analysis is proposed for the absolute phase map retrieval to spatially isolated objects. The results demonstrate the validity and the accuracy of the proposed flexible fringe projection vision system on spatially continuous and discontinuous objects for 3D measurement. PMID:27136553

  18. A Flexible Fringe Projection Vision System with Extended Mathematical Model for Accurate Three-Dimensional Measurement.

    PubMed

    Xiao, Suzhi; Tao, Wei; Zhao, Hui

    2016-01-01

    In order to acquire an accurate three-dimensional (3D) measurement, the traditional fringe projection technique applies complex and laborious procedures to compensate for the errors that exist in the vision system. However, the error sources in the vision system are very complex, such as lens distortion, lens defocus, and fringe pattern nonsinusoidality. Some errors cannot even be explained or rendered with clear expressions and are difficult to compensate directly as a result. In this paper, an approach is proposed that avoids the complex and laborious compensation procedure for error sources but still promises accurate 3D measurement. It is realized by the mathematical model extension technique. The parameters of the extended mathematical model for the 'phase to 3D coordinates transformation' are derived using the least-squares parameter estimation algorithm. In addition, a phase-coding method based on a frequency analysis is proposed for the absolute phase map retrieval to spatially isolated objects. The results demonstrate the validity and the accuracy of the proposed flexible fringe projection vision system on spatially continuous and discontinuous objects for 3D measurement. PMID:27136553

  19. Universal model for accurate calculation of tracer diffusion coefficients in gas, liquid and supercritical systems.

    PubMed

    Lito, Patrícia F; Magalhães, Ana L; Gomes, José R B; Silva, Carlos M

    2013-05-17

    In this work it is presented a new model for accurate calculation of binary diffusivities (D12) of solutes infinitely diluted in gas, liquid and supercritical solvents. It is based on a Lennard-Jones (LJ) model, and contains two parameters: the molecular diameter of the solvent and a diffusion activation energy. The model is universal since it is applicable to polar, weakly polar, and non-polar solutes and/or solvents, over wide ranges of temperature and density. Its validation was accomplished with the largest database ever compiled, namely 487 systems with 8293 points totally, covering polar (180 systems/2335 points) and non-polar or weakly polar (307 systems/5958 points) mixtures, for which the average errors were 2.65% and 2.97%, respectively. With regard to the physical states of the systems, the average deviations achieved were 1.56% for gaseous (73 systems/1036 points), 2.90% for supercritical (173 systems/4398 points), and 2.92% for liquid (241 systems/2859 points). Furthermore, the model exhibited excellent prediction ability. Ten expressions from the literature were adopted for comparison, but provided worse results or were not applicable to polar systems. A spreadsheet for D12 calculation is provided online for users in Supplementary Data.

  20. Multireference linearized coupled cluster theory for strongly correlated systems using matrix product states

    SciTech Connect

    Sharma, Sandeep; Alavi, Ali

    2015-09-14

    We propose a multireference linearized coupled cluster theory using matrix product states (MPSs-LCC) which provides remarkably accurate ground-state energies, at a computational cost that has the same scaling as multireference configuration interaction singles and doubles, for a wide variety of electronic Hamiltonians. These range from first-row dimers at equilibrium and stretched geometries to highly multireference systems such as the chromium dimer and lattice models such as periodic two-dimensional 1-band and 3-band Hubbard models. The MPS-LCC theory shows a speed up of several orders of magnitude over the usual Density Matrix Renormalization Group (DMRG) algorithm while delivering energies in excellent agreement with converged DMRG calculations. Also, in all the benchmark calculations presented here, MPS-LCC outperformed the commonly used multi-reference quantum chemistry methods in some cases giving energies in excess of an order of magnitude more accurate. As a size-extensive method that can treat large active spaces, MPS-LCC opens up the use of multireference quantum chemical techniques in strongly correlated ab initio Hamiltonians, including two- and three-dimensional solids.

  1. Multireference linearized coupled cluster theory for strongly correlated systems using matrix product states.

    PubMed

    Sharma, Sandeep; Alavi, Ali

    2015-09-14

    We propose a multireference linearized coupled cluster theory using matrix product states (MPSs-LCC) which provides remarkably accurate ground-state energies, at a computational cost that has the same scaling as multireference configuration interaction singles and doubles, for a wide variety of electronic Hamiltonians. These range from first-row dimers at equilibrium and stretched geometries to highly multireference systems such as the chromium dimer and lattice models such as periodic two-dimensional 1-band and 3-band Hubbard models. The MPS-LCC theory shows a speed up of several orders of magnitude over the usual Density Matrix Renormalization Group (DMRG) algorithm while delivering energies in excellent agreement with converged DMRG calculations. Also, in all the benchmark calculations presented here, MPS-LCC outperformed the commonly used multi-reference quantum chemistry methods in some cases giving energies in excess of an order of magnitude more accurate. As a size-extensive method that can treat large active spaces, MPS-LCC opens up the use of multireference quantum chemical techniques in strongly correlated ab initio Hamiltonians, including two- and three-dimensional solids. PMID:26374008

  2. Multireference linearized coupled cluster theory for strongly correlated systems using matrix product states.

    PubMed

    Sharma, Sandeep; Alavi, Ali

    2015-09-14

    We propose a multireference linearized coupled cluster theory using matrix product states (MPSs-LCC) which provides remarkably accurate ground-state energies, at a computational cost that has the same scaling as multireference configuration interaction singles and doubles, for a wide variety of electronic Hamiltonians. These range from first-row dimers at equilibrium and stretched geometries to highly multireference systems such as the chromium dimer and lattice models such as periodic two-dimensional 1-band and 3-band Hubbard models. The MPS-LCC theory shows a speed up of several orders of magnitude over the usual Density Matrix Renormalization Group (DMRG) algorithm while delivering energies in excellent agreement with converged DMRG calculations. Also, in all the benchmark calculations presented here, MPS-LCC outperformed the commonly used multi-reference quantum chemistry methods in some cases giving energies in excess of an order of magnitude more accurate. As a size-extensive method that can treat large active spaces, MPS-LCC opens up the use of multireference quantum chemical techniques in strongly correlated ab initio Hamiltonians, including two- and three-dimensional solids.

  3. Analytical solutions of solute transport in a fracture-matrix system with different reaction rates for fracture and matrix

    NASA Astrophysics Data System (ADS)

    Zhu, Yonghui; Zhan, Hongbin; Jin, Menggui

    2016-08-01

    This study deals with the problem of reactive solute transport in a fracture-matrix system using both analytical and numerical modeling methods. The groundwater flow velocity in the fracture is assumed to be high enough (no less than 0.1 m/day) to ensure the advection-dominant transport in the fracture. The problem includes advection along the fracture, transverse diffusion in the matrix, with linear sorption as well as first-order reactions operative in both the fracture and the matrix. A constant-concentration boundary condition and a decay source boundary condition in the fracture are considered. With a constant-concentration source, we obtain closed-form analytical solutions that account for the transport without reaction as well as steady-state solutions with different first-order reactions in the two media. With a decay source, a semi-analytical solution is obtained. The analytical and semi-analytical solutions are in excellent agreement with the numerical simulation results obtained using COMSOL Multiphysics. Sensitivity analysis is conducted to assess the relative importance of matrix diffusion coefficient, fracture aperture, and matrix porosity. We conclude that the first-order reaction as well as the matrix diffusion in the fractured rock would decrease the solute peak concentration and shorten the penetration distance into the fracture. The solutions can be applied to assess the spatial-temporal distribution of concentrations in the fracture and the matrix as well as to assess the contaminant mass stored in the rock matrix. All of these are useful for designing remediation plans for contaminated fractured rocks or for risk assessment of contaminated fracture-matrix systems.

  4. Accurate and automatic extrinsic calibration method for blade measurement system integrated by different optical sensors

    NASA Astrophysics Data System (ADS)

    He, Wantao; Li, Zhongwei; Zhong, Kai; Shi, Yusheng; Zhao, Can; Cheng, Xu

    2014-11-01

    Fast and precise 3D inspection system is in great demand in modern manufacturing processes. At present, the available sensors have their own pros and cons, and hardly exist an omnipotent sensor to handle the complex inspection task in an accurate and effective way. The prevailing solution is integrating multiple sensors and taking advantages of their strengths. For obtaining a holistic 3D profile, the data from different sensors should be registrated into a coherent coordinate system. However, some complex shape objects own thin wall feather such as blades, the ICP registration method would become unstable. Therefore, it is very important to calibrate the extrinsic parameters of each sensor in the integrated measurement system. This paper proposed an accurate and automatic extrinsic parameter calibration method for blade measurement system integrated by different optical sensors. In this system, fringe projection sensor (FPS) and conoscopic holography sensor (CHS) is integrated into a multi-axis motion platform, and the sensors can be optimally move to any desired position at the object's surface. In order to simple the calibration process, a special calibration artifact is designed according to the characteristics of the two sensors. An automatic registration procedure based on correlation and segmentation is used to realize the artifact datasets obtaining by FPS and CHS rough alignment without any manual operation and data pro-processing, and then the Generalized Gauss-Markoff model is used to estimate the optimization transformation parameters. The experiments show the measurement result of a blade, where several sampled patches are merged into one point cloud, and it verifies the performance of the proposed method.

  5. Distributed fiber sensing system with wide frequency response and accurate location

    NASA Astrophysics Data System (ADS)

    Shi, Yi; Feng, Hao; Zeng, Zhoumo

    2016-02-01

    A distributed fiber sensing system merging Mach-Zehnder interferometer and phase-sensitive optical time domain reflectometer (Φ-OTDR) is demonstrated for vibration measurement, which requires wide frequency response and accurate location. Two narrow line-width lasers with delicately different wavelengths are used to constitute the interferometer and reflectometer respectively. A narrow band Fiber Bragg Grating is responsible for separating the two wavelengths. In addition, heterodyne detection is applied to maintain the signal to noise rate of the locating signal. Experiment results show that the novel system has a wide frequency from 1 Hz to 50 MHz, limited by the sample frequency of data acquisition card, and a spatial resolution of 20 m, according to 200 ns pulse width, along 2.5 km fiber link.

  6. Development of Metal Matrix Composites for NASA'S Advanced Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Lee, Jonathan A.

    2000-01-01

    The state-of-the-art development of several aluminum and copper based Metal Matrix Composites (MMC) for NASA's advanced propulsion systems will be presented. The presentation's goal is to provide an overview of NASA-Marshall Space Flight Center's planned and on-going activities in MMC for advanced liquid rocket engines such as the X-33 vehicle's Aerospike and X-34 Fastrac engine. The focus will be on lightweight and environmental compatibility with oxygen and hydrogen of key MMC materials, within each NASA's new propulsion application, that will provide a high payoff for NASA's reusable launch vehicle systems and space access vehicles. Advanced MMC processing techniques such as plasma spray, centrifugal casting, pressure infiltration casting will be discussed. Development of a novel 3D printing method for low cost production of composite preform, and functional gradient MMC to enhanced rocket engine's dimensional stability will be presented.

  7. Numerical modelling and experimental investigation of drug release from layered silicone matrix systems.

    PubMed

    Snorradóttir, Bergthóra S; Jónsdóttir, Fjóla; Sigurdsson, Sven Th; Thorsteinsson, Freygardur; Másson, Már

    2013-07-16

    Medical devices and polymeric matrix systems that release drugs or other bioactive compounds are of interest for a variety of applications. The release of the drug can be dependent on a number of factors such as the solubility, diffusivity, dissolution rate and distribution of the solid drug in the matrix. Achieving the goal of an optimal release profile can be challenging when relying solely on traditional experimental work. Accurate modelling complementing experimentation is therefore desirable. Numerical modelling is increasingly becoming an integral part of research and development due to the significant advances in computer simulation technology. This work focuses on numerical modelling and investigation of multi-layered silicone matrix systems. A numerical model that can be used to model multi-layered systems was constructed and validated by comparison with experimental data. The model could account for the limited dissolution rate and effect of the drug distribution on the release profiles. Parametric study showed how different factors affect the characteristics of drug release. Multi-layered medical silicone matrices were prepared in special moulds, where the quantity of drug in each layer could be varied, and release was investigated with Franz-diffusion cell setup. Data for long-term release was fitted to the model and the full depletion of the system predicted. The numerical model constructed for this study, whose input parameters are the diffusion, effective dissolution rate and dimensional solubility coefficients, does not require any type of steady-state approximation. These results indicate that numerical model can be used as a design tool for development of controlled release systems such as drug-loaded medical devices.

  8. Accurate first-principles structures and energies of diversely bonded systems from an efficient density functional

    NASA Astrophysics Data System (ADS)

    Sun, Jianwei; Remsing, Richard C.; Zhang, Yubo; Sun, Zhaoru; Ruzsinszky, Adrienn; Peng, Haowei; Yang, Zenghui; Paul, Arpita; Waghmare, Umesh; Wu, Xifan; Klein, Michael L.; Perdew, John P.

    2016-09-01

    One atom or molecule binds to another through various types of bond, the strengths of which range from several meV to several eV. Although some computational methods can provide accurate descriptions of all bond types, those methods are not efficient enough for many studies (for example, large systems, ab initio molecular dynamics and high-throughput searches for functional materials). Here, we show that the recently developed non-empirical strongly constrained and appropriately normed (SCAN) meta-generalized gradient approximation (meta-GGA) within the density functional theory framework predicts accurate geometries and energies of diversely bonded molecules and materials (including covalent, metallic, ionic, hydrogen and van der Waals bonds). This represents a significant improvement at comparable efficiency over its predecessors, the GGAs that currently dominate materials computation. Often, SCAN matches or improves on the accuracy of a computationally expensive hybrid functional, at almost-GGA cost. SCAN is therefore expected to have a broad impact on chemistry and materials science.

  9. Accurate first-principles structures and energies of diversely bonded systems from an efficient density functional.

    PubMed

    Sun, Jianwei; Remsing, Richard C; Zhang, Yubo; Sun, Zhaoru; Ruzsinszky, Adrienn; Peng, Haowei; Yang, Zenghui; Paul, Arpita; Waghmare, Umesh; Wu, Xifan; Klein, Michael L; Perdew, John P

    2016-09-01

    One atom or molecule binds to another through various types of bond, the strengths of which range from several meV to several eV. Although some computational methods can provide accurate descriptions of all bond types, those methods are not efficient enough for many studies (for example, large systems, ab initio molecular dynamics and high-throughput searches for functional materials). Here, we show that the recently developed non-empirical strongly constrained and appropriately normed (SCAN) meta-generalized gradient approximation (meta-GGA) within the density functional theory framework predicts accurate geometries and energies of diversely bonded molecules and materials (including covalent, metallic, ionic, hydrogen and van der Waals bonds). This represents a significant improvement at comparable efficiency over its predecessors, the GGAs that currently dominate materials computation. Often, SCAN matches or improves on the accuracy of a computationally expensive hybrid functional, at almost-GGA cost. SCAN is therefore expected to have a broad impact on chemistry and materials science. PMID:27554409

  10. Fully Automatic System for Accurate Localisation and Analysis of Cephalometric Landmarks in Lateral Cephalograms

    PubMed Central

    Lindner, Claudia; Wang, Ching-Wei; Huang, Cheng-Ta; Li, Chung-Hsing; Chang, Sheng-Wei; Cootes, Tim F.

    2016-01-01

    Cephalometric tracing is a standard analysis tool for orthodontic diagnosis and treatment planning. The aim of this study was to develop and validate a fully automatic landmark annotation (FALA) system for finding cephalometric landmarks in lateral cephalograms and its application to the classification of skeletal malformations. Digital cephalograms of 400 subjects (age range: 7–76 years) were available. All cephalograms had been manually traced by two experienced orthodontists with 19 cephalometric landmarks, and eight clinical parameters had been calculated for each subject. A FALA system to locate the 19 landmarks in lateral cephalograms was developed. The system was evaluated via comparison to the manual tracings, and the automatically located landmarks were used for classification of the clinical parameters. The system achieved an average point-to-point error of 1.2 mm, and 84.7% of landmarks were located within the clinically accepted precision range of 2.0 mm. The automatic landmark localisation performance was within the inter-observer variability between two clinical experts. The automatic classification achieved an average classification accuracy of 83.4% which was comparable to an experienced orthodontist. The FALA system rapidly and accurately locates and analyses cephalometric landmarks in lateral cephalograms, and has the potential to significantly improve the clinical work flow in orthodontic treatment. PMID:27645567

  11. Fully Automatic System for Accurate Localisation and Analysis of Cephalometric Landmarks in Lateral Cephalograms.

    PubMed

    Lindner, Claudia; Wang, Ching-Wei; Huang, Cheng-Ta; Li, Chung-Hsing; Chang, Sheng-Wei; Cootes, Tim F

    2016-09-20

    Cephalometric tracing is a standard analysis tool for orthodontic diagnosis and treatment planning. The aim of this study was to develop and validate a fully automatic landmark annotation (FALA) system for finding cephalometric landmarks in lateral cephalograms and its application to the classification of skeletal malformations. Digital cephalograms of 400 subjects (age range: 7-76 years) were available. All cephalograms had been manually traced by two experienced orthodontists with 19 cephalometric landmarks, and eight clinical parameters had been calculated for each subject. A FALA system to locate the 19 landmarks in lateral cephalograms was developed. The system was evaluated via comparison to the manual tracings, and the automatically located landmarks were used for classification of the clinical parameters. The system achieved an average point-to-point error of 1.2 mm, and 84.7% of landmarks were located within the clinically accepted precision range of 2.0 mm. The automatic landmark localisation performance was within the inter-observer variability between two clinical experts. The automatic classification achieved an average classification accuracy of 83.4% which was comparable to an experienced orthodontist. The FALA system rapidly and accurately locates and analyses cephalometric landmarks in lateral cephalograms, and has the potential to significantly improve the clinical work flow in orthodontic treatment.

  12. Fully Automatic System for Accurate Localisation and Analysis of Cephalometric Landmarks in Lateral Cephalograms.

    PubMed

    Lindner, Claudia; Wang, Ching-Wei; Huang, Cheng-Ta; Li, Chung-Hsing; Chang, Sheng-Wei; Cootes, Tim F

    2016-01-01

    Cephalometric tracing is a standard analysis tool for orthodontic diagnosis and treatment planning. The aim of this study was to develop and validate a fully automatic landmark annotation (FALA) system for finding cephalometric landmarks in lateral cephalograms and its application to the classification of skeletal malformations. Digital cephalograms of 400 subjects (age range: 7-76 years) were available. All cephalograms had been manually traced by two experienced orthodontists with 19 cephalometric landmarks, and eight clinical parameters had been calculated for each subject. A FALA system to locate the 19 landmarks in lateral cephalograms was developed. The system was evaluated via comparison to the manual tracings, and the automatically located landmarks were used for classification of the clinical parameters. The system achieved an average point-to-point error of 1.2 mm, and 84.7% of landmarks were located within the clinically accepted precision range of 2.0 mm. The automatic landmark localisation performance was within the inter-observer variability between two clinical experts. The automatic classification achieved an average classification accuracy of 83.4% which was comparable to an experienced orthodontist. The FALA system rapidly and accurately locates and analyses cephalometric landmarks in lateral cephalograms, and has the potential to significantly improve the clinical work flow in orthodontic treatment. PMID:27645567

  13. Simulated one-pass list-mode: an approach to on-the-fly system matrix calculation.

    PubMed

    Gillam, J E; Solevi, P; Oliver, J F; Rafecas, M

    2013-04-01

    standard (highly accurate) system matrix using experimental data from a prototype system--the AX-PET.

  14. Highly accurate moving object detection in variable bit rate video-based traffic monitoring systems.

    PubMed

    Huang, Shih-Chia; Chen, Bo-Hao

    2013-12-01

    Automated motion detection, which segments moving objects from video streams, is the key technology of intelligent transportation systems for traffic management. Traffic surveillance systems use video communication over real-world networks with limited bandwidth, which frequently suffers because of either network congestion or unstable bandwidth. Evidence supporting these problems abounds in publications about wireless video communication. Thus, to effectively perform the arduous task of motion detection over a network with unstable bandwidth, a process by which bit-rate is allocated to match the available network bandwidth is necessitated. This process is accomplished by the rate control scheme. This paper presents a new motion detection approach that is based on the cerebellar-model-articulation-controller (CMAC) through artificial neural networks to completely and accurately detect moving objects in both high and low bit-rate video streams. The proposed approach is consisted of a probabilistic background generation (PBG) module and a moving object detection (MOD) module. To ensure that the properties of variable bit-rate video streams are accommodated, the proposed PBG module effectively produces a probabilistic background model through an unsupervised learning process over variable bit-rate video streams. Next, the MOD module, which is based on the CMAC network, completely and accurately detects moving objects in both low and high bit-rate video streams by implementing two procedures: 1) a block selection procedure and 2) an object detection procedure. The detection results show that our proposed approach is capable of performing with higher efficacy when compared with the results produced by other state-of-the-art approaches in variable bit-rate video streams over real-world limited bandwidth networks. Both qualitative and quantitative evaluations support this claim; for instance, the proposed approach achieves Similarity and F1 accuracy rates that are 76

  15. Can radiation therapy treatment planning system accurately predict surface doses in postmastectomy radiation therapy patients?

    SciTech Connect

    Wong, Sharon; Back, Michael; Tan, Poh Wee; Lee, Khai Mun; Baggarley, Shaun; Lu, Jaide Jay

    2012-07-01

    Skin doses have been an important factor in the dose prescription for breast radiotherapy. Recent advances in radiotherapy treatment techniques, such as intensity-modulated radiation therapy (IMRT) and new treatment schemes such as hypofractionated breast therapy have made the precise determination of the surface dose necessary. Detailed information of the dose at various depths of the skin is also critical in designing new treatment strategies. The purpose of this work was to assess the accuracy of surface dose calculation by a clinically used treatment planning system and those measured by thermoluminescence dosimeters (TLDs) in a customized chest wall phantom. This study involved the construction of a chest wall phantom for skin dose assessment. Seven TLDs were distributed throughout each right chest wall phantom to give adequate representation of measured radiation doses. Point doses from the CMS Xio Registered-Sign treatment planning system (TPS) were calculated for each relevant TLD positions and results correlated. There were no significant difference between measured absorbed dose by TLD and calculated doses by the TPS (p > 0.05 (1-tailed). Dose accuracy of up to 2.21% was found. The deviations from the calculated absorbed doses were overall larger (3.4%) when wedges and bolus were used. 3D radiotherapy TPS is a useful and accurate tool to assess the accuracy of surface dose. Our studies have shown that radiation treatment accuracy expressed as a comparison between calculated doses (by TPS) and measured doses (by TLD dosimetry) can be accurately predicted for tangential treatment of the chest wall after mastectomy.

  16. Highly accurate moving object detection in variable bit rate video-based traffic monitoring systems.

    PubMed

    Huang, Shih-Chia; Chen, Bo-Hao

    2013-12-01

    Automated motion detection, which segments moving objects from video streams, is the key technology of intelligent transportation systems for traffic management. Traffic surveillance systems use video communication over real-world networks with limited bandwidth, which frequently suffers because of either network congestion or unstable bandwidth. Evidence supporting these problems abounds in publications about wireless video communication. Thus, to effectively perform the arduous task of motion detection over a network with unstable bandwidth, a process by which bit-rate is allocated to match the available network bandwidth is necessitated. This process is accomplished by the rate control scheme. This paper presents a new motion detection approach that is based on the cerebellar-model-articulation-controller (CMAC) through artificial neural networks to completely and accurately detect moving objects in both high and low bit-rate video streams. The proposed approach is consisted of a probabilistic background generation (PBG) module and a moving object detection (MOD) module. To ensure that the properties of variable bit-rate video streams are accommodated, the proposed PBG module effectively produces a probabilistic background model through an unsupervised learning process over variable bit-rate video streams. Next, the MOD module, which is based on the CMAC network, completely and accurately detects moving objects in both low and high bit-rate video streams by implementing two procedures: 1) a block selection procedure and 2) an object detection procedure. The detection results show that our proposed approach is capable of performing with higher efficacy when compared with the results produced by other state-of-the-art approaches in variable bit-rate video streams over real-world limited bandwidth networks. Both qualitative and quantitative evaluations support this claim; for instance, the proposed approach achieves Similarity and F1 accuracy rates that are 76

  17. Development of Metal Matrix Composites for NASA's Advanced Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Lee, J.; Elam, S.

    2001-01-01

    The state-of-the-art development of several Metal Matrix Composites (MMC) for NASA's advanced propulsion systems will be presented. The goal is to provide an overview of NASA-Marshall Space Flight Center's on-going activities in MMC components for advanced liquid rocket engines such as the X-33 vehicle's Aerospike engine and X-34's Fastrac engine. The focus will be on lightweight, low cost, and environmental compatibility with oxygen and hydrogen of key MMC materials, within each of NASA's new propulsion application, that will provide a high payoff for NASA's Reusable Launch Vehicles and space access vehicles. In order to fabricate structures from MMC, effective joining methods must be developed to join MMC to the same or to different monolithic alloys. Therefore, a qualitative assessment of MMC's welding and joining techniques will be outlined.

  18. A Three-Dimensional Parallel Time-Accurate Turbopump Simulation Procedure Using Overset Grid System

    NASA Technical Reports Server (NTRS)

    Kiris, Cetin; Chan, William; Kwak, Dochan

    2002-01-01

    The objective of the current effort is to provide a computational framework for design and analysis of the entire fuel supply system of a liquid rocket engine, including high-fidelity unsteady turbopump flow analysis. This capability is needed to support the design of pump sub-systems for advanced space transportation vehicles that are likely to involve liquid propulsion systems. To date, computational tools for design/analysis of turbopump flows are based on relatively lower fidelity methods. An unsteady, three-dimensional viscous flow analysis tool involving stationary and rotational components for the entire turbopump assembly has not been available for real-world engineering applications. The present effort provides developers with information such as transient flow phenomena at start up, and nonuniform inflows, and will eventually impact on system vibration and structures. In the proposed paper, the progress toward the capability of complete simulation of the turbo-pump for a liquid rocket engine is reported. The Space Shuttle Main Engine (SSME) turbo-pump is used as a test case for evaluation of the hybrid MPI/Open-MP and MLP versions of the INS3D code. CAD to solution auto-scripting capability is being developed for turbopump applications. The relative motion of the grid systems for the rotor-stator interaction was obtained using overset grid techniques. Unsteady computations for the SSME turbo-pump, which contains 114 zones with 34.5 million grid points, are carried out on Origin 3000 systems at NASA Ames Research Center. Results from these time-accurate simulations with moving boundary capability are presented along with the performance of parallel versions of the code.

  19. A Three Dimensional Parallel Time Accurate Turbopump Simulation Procedure Using Overset Grid Systems

    NASA Technical Reports Server (NTRS)

    Kiris, Cetin; Chan, William; Kwak, Dochan

    2001-01-01

    The objective of the current effort is to provide a computational framework for design and analysis of the entire fuel supply system of a liquid rocket engine, including high-fidelity unsteady turbopump flow analysis. This capability is needed to support the design of pump sub-systems for advanced space transportation vehicles that are likely to involve liquid propulsion systems. To date, computational tools for design/analysis of turbopump flows are based on relatively lower fidelity methods. An unsteady, three-dimensional viscous flow analysis tool involving stationary and rotational components for the entire turbopump assembly has not been available for real-world engineering applications. The present effort provides developers with information such as transient flow phenomena at start up, and non-uniform inflows, and will eventually impact on system vibration and structures. In the proposed paper, the progress toward the capability of complete simulation of the turbo-pump for a liquid rocket engine is reported. The Space Shuttle Main Engine (SSME) turbo-pump is used as a test case for evaluation of the hybrid MPI/Open-MP and MLP versions of the INS3D code. CAD to solution auto-scripting capability is being developed for turbopump applications. The relative motion of the grid systems for the rotor-stator interaction was obtained using overset grid techniques. Unsteady computations for the SSME turbo-pump, which contains 114 zones with 34.5 million grid points, are carried out on Origin 3000 systems at NASA Ames Research Center. Results from these time-accurate simulations with moving boundary capability will be presented along with the performance of parallel versions of the code.

  20. A miniature shoe-mounted orientation determination system for accurate indoor heading and trajectory tracking.

    PubMed

    Zhang, Shengzhi; Yu, Shuai; Liu, Chaojun; Liu, Sheng

    2016-06-01

    Tracking the position of pedestrian is urgently demanded when the most commonly used GPS (Global Position System) is unavailable. Benefited from the small size, low-power consumption, and relatively high reliability, micro-electro-mechanical system sensors are well suited for GPS-denied indoor pedestrian heading estimation. In this paper, a real-time miniature orientation determination system (MODS) was developed for indoor heading and trajectory tracking based on a novel dual-linear Kalman filter. The proposed filter precludes the impact of geomagnetic distortions on pitch and roll that the heading is subjected to. A robust calibration approach was designed to improve the accuracy of sensors measurements based on a unified sensor model. Online tests were performed on the MODS with an improved turntable. The results demonstrate that the average RMSE (root-mean-square error) of heading estimation is less than 1°. Indoor heading experiments were carried out with the MODS mounted on the shoe of pedestrian. Besides, we integrated the existing MODS into an indoor pedestrian dead reckoning application as an example of its utility in realistic actions. A human attitude-based walking model was developed to calculate the walking distance. Test results indicate that mean percentage error of indoor trajectory tracking achieves 2% of the total walking distance. This paper provides a feasible alternative for accurate indoor heading and trajectory tracking. PMID:27370490

  1. A miniature shoe-mounted orientation determination system for accurate indoor heading and trajectory tracking

    NASA Astrophysics Data System (ADS)

    Zhang, Shengzhi; Yu, Shuai; Liu, Chaojun; Liu, Sheng

    2016-06-01

    Tracking the position of pedestrian is urgently demanded when the most commonly used GPS (Global Position System) is unavailable. Benefited from the small size, low-power consumption, and relatively high reliability, micro-electro-mechanical system sensors are well suited for GPS-denied indoor pedestrian heading estimation. In this paper, a real-time miniature orientation determination system (MODS) was developed for indoor heading and trajectory tracking based on a novel dual-linear Kalman filter. The proposed filter precludes the impact of geomagnetic distortions on pitch and roll that the heading is subjected to. A robust calibration approach was designed to improve the accuracy of sensors measurements based on a unified sensor model. Online tests were performed on the MODS with an improved turntable. The results demonstrate that the average RMSE (root-mean-square error) of heading estimation is less than 1°. Indoor heading experiments were carried out with the MODS mounted on the shoe of pedestrian. Besides, we integrated the existing MODS into an indoor pedestrian dead reckoning application as an example of its utility in realistic actions. A human attitude-based walking model was developed to calculate the walking distance. Test results indicate that mean percentage error of indoor trajectory tracking achieves 2% of the total walking distance. This paper provides a feasible alternative for accurate indoor heading and trajectory tracking.

  2. Fast, automatic, and accurate catheter reconstruction in HDR brachytherapy using an electromagnetic 3D tracking system

    SciTech Connect

    Poulin, Eric; Racine, Emmanuel; Beaulieu, Luc; Binnekamp, Dirk

    2015-03-15

    Purpose: In high dose rate brachytherapy (HDR-B), current catheter reconstruction protocols are relatively slow and error prone. The purpose of this technical note is to evaluate the accuracy and the robustness of an electromagnetic (EM) tracking system for automated and real-time catheter reconstruction. Methods: For this preclinical study, a total of ten catheters were inserted in gelatin phantoms with different trajectories. Catheters were reconstructed using a 18G biopsy needle, used as an EM stylet and equipped with a miniaturized sensor, and the second generation Aurora{sup ®} Planar Field Generator from Northern Digital Inc. The Aurora EM system provides position and orientation value with precisions of 0.7 mm and 0.2°, respectively. Phantoms were also scanned using a μCT (GE Healthcare) and Philips Big Bore clinical computed tomography (CT) system with a spatial resolution of 89 μm and 2 mm, respectively. Reconstructions using the EM stylet were compared to μCT and CT. To assess the robustness of the EM reconstruction, five catheters were reconstructed twice and compared. Results: Reconstruction time for one catheter was 10 s, leading to a total reconstruction time inferior to 3 min for a typical 17-catheter implant. When compared to the μCT, the mean EM tip identification error was 0.69 ± 0.29 mm while the CT error was 1.08 ± 0.67 mm. The mean 3D distance error was found to be 0.66 ± 0.33 mm and 1.08 ± 0.72 mm for the EM and CT, respectively. EM 3D catheter trajectories were found to be more accurate. A maximum difference of less than 0.6 mm was found between successive EM reconstructions. Conclusions: The EM reconstruction was found to be more accurate and precise than the conventional methods used for catheter reconstruction in HDR-B. This approach can be applied to any type of catheters and applicators.

  3. Matrix-assisted laser desorption ionization-time of flight mass spectrometry can accurately differentiate Aeromonas dhakensis from A. hydrophila, A. caviae, and A. veronii.

    PubMed

    Chen, Po-Lin; Lee, Tai-Fen; Wu, Chi-Jung; Teng, Shih-Hua; Teng, Lee-Jene; Ko, Wen-Chien; Hsueh, Po-Ren

    2014-07-01

    Among 217 Aeromonas isolates identified by sequencing analysis of their rpoB genes, the accuracy rates of identification of A. dhakensis, A. hydrophila, A. veronii, and A. caviae were 96.7%, 90.0%, 96.7%, and 100.0%, respectively, by the cluster analysis of spectra generated by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

  4. An Approach to More Accurate Model Systems for Purple Acid Phosphatases (PAPs).

    PubMed

    Bernhardt, Paul V; Bosch, Simone; Comba, Peter; Gahan, Lawrence R; Hanson, Graeme R; Mereacre, Valeriu; Noble, Christopher J; Powell, Annie K; Schenk, Gerhard; Wadepohl, Hubert

    2015-08-01

    The active site of mammalian purple acid phosphatases (PAPs) have a dinuclear iron site in two accessible oxidation states (Fe(III)2 and Fe(III)Fe(II)), and the heterovalent is the active form, involved in the regulation of phosphate and phosphorylated metabolite levels in a wide range of organisms. Therefore, two sites with different coordination geometries to stabilize the heterovalent active form and, in addition, with hydrogen bond donors to enable the fixation of the substrate and release of the product, are believed to be required for catalytically competent model systems. Two ligands and their dinuclear iron complexes have been studied in detail. The solid-state structures and properties, studied by X-ray crystallography, magnetism, and Mössbauer spectroscopy, and the solution structural and electronic properties, investigated by mass spectrometry, electronic, nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), and Mössbauer spectroscopies and electrochemistry, are discussed in detail in order to understand the structures and relative stabilities in solution. In particular, with one of the ligands, a heterovalent Fe(III)Fe(II) species has been produced by chemical oxidation of the Fe(II)2 precursor. The phosphatase reactivities of the complexes, in particular, also of the heterovalent complex, are reported. These studies include pH-dependent as well as substrate concentration dependent studies, leading to pH profiles, catalytic efficiencies and turnover numbers, and indicate that the heterovalent diiron complex discussed here is an accurate PAP model system. PMID:26196255

  5. Generation IV nuclear energy systems and the need of accurate nuclear data

    NASA Astrophysics Data System (ADS)

    Colonna, N.

    2009-05-01

    To satisfy the world's demand of energy, constantly increasing over the years, a suitable mix of different energy sources has to be envisaged. In this scenario, an important role may be played by nuclear energy, provided that major safety, waste and proliferation issues affecting current nuclear reactors are satisfactorily addressed. In this respect, a large effort is under way since a few years towards the development of advanced nuclear systems that would use more efficiently the uranium resources, and produce a minimal amount of long-lived nuclear waste. The main activity concerns Generation IV reactors, with full or partial waste recycling capability. Their design requires R&D in numerous fields. Among the different needs, it is of fundamental importance to improve the knowledge of basic nuclear data, such as cross-sections for neutron-induced reactions on actinides. The main characteristics and principle of operation of the new generation nuclear systems are here described, together with the related needs of new and accurate nuclear data. Finally, an example of activity currently undergoing in the field is shown, with the recent experimental results obtained at the neutron facility n_TOF at CERN.

  6. Robust and accurate visual echo cancellation in a full-duplex projector-camera system.

    PubMed

    Liao, Miao; Yang, Ruigang; Zhang, Zhengyou

    2008-10-01

    In this paper we study the problem of "visual echo" in a full-duplex projector-camera system for telecollaboration applications. Visual echo is defined as the appearance of projected contents observed by the camera. It can potentially saturate the projected contents, similar to audio echo in telephone conversation. Our approach to visual echo cancellation includes an offline calibration procedure that records the geometric and photometric transfer between the projector and the camera in a look-up table. During run-time, projected contents in the captured video are identified using the calibration information and suppressed, therefore achieving the goal of cancelling visual echo. Our approach can accurately handle full-color images under arbitrary reflectance of display surfaces and photometric response of the projector or camera. It is robust to geometric registration errors and quantization effects and is therefore particularly effective for high-frequency contents such as texts and hand drawings. We demonstrate the effectiveness of our approach with a variety of real images in a full-duplex projector-camera system.

  7. Radiative transfer solutions for coupled atmosphere ocean systems using the matrix operator technique

    NASA Astrophysics Data System (ADS)

    Hollstein, André; Fischer, Jürgen

    2012-05-01

    Accurate radiative transfer models are the key tools for the understanding of radiative transfer processes in the atmosphere and ocean, and for the development of remote sensing algorithms. The widely used scalar approximation of radiative transfer can lead to errors in calculated top of atmosphere radiances. We show results with errors in the order of±8% for atmosphere ocean systems with case one waters. Variations in sea water salinity and temperature can lead to variations in the signal of similar magnitude. Therefore, we enhanced our scalar radiative transfer model MOMO, which is in use at Freie Universität Berlin, to treat these effects as accurately as possible. We describe our one-dimensional vector radiative transfer model for an atmosphere ocean system with a rough interface. We describe the matrix operator scheme and the bio-optical model for case one waters. We discuss some effects of neglecting polarization in radiative transfer calculations and effects of salinity changes for top of atmosphere radiances. Results are shown for the channels of the satellite instruments MERIS and OLCI from 412.5 nm to 900 nm.

  8. Modal cost analysis for linear matrix-second-order systems

    NASA Technical Reports Server (NTRS)

    Skelton, R. E.; Hughes, P. C.

    1980-01-01

    Reduced models and reduced controllers for systems governed by matrix-second-order differential equations are obtained by retaining those modes which make the largest contributions to quadratic control objectives. Such contributions, expressed in terms of modal data, used as mode truncation criteria, allow the statement of the specific control objectives to influence the early model reduction from very high order models which are available, for example, from finite element methods. The relative importance of damping, frequency, and eigenvector in the mode truncation decisions are made explicit for each of these control objectives: attitude control, vibration suppression and figure control. The paper also shows that using modal cost analysis (MCA) on the closed loop modes of the optimally controlled system allows the construction of reduced control policies which feedback only those closed loop modal coordinates which are most critical to the quadratic control performance criterion. In this way, the modes which should be controlled (and hence the modes which must be observable by choice of measurements), are deduced from truncations of the optimal controller.

  9. PHARMACODYNAMICAL EVALUATION OF MATRIX TYPE TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING CAPTOPRIL.

    PubMed

    Kerımoğlu, Oya; Şahbaz, Sevınç; Şehırlı, Özer; Ozdemır, Zarıfe Nıgar; Çetınel, Şule; Dortunç, Betül; Şener, Göksel

    2015-01-01

    The objective of this study was to evaluate pharmacodynamical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. Optimum formulation was chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using Franz Diffusion Cell. Control group, hypertension group (HT) and TTS containing captopril hypertension group (HT-CAP) were assessed for the pharmacodynamic activity of the study. Pharmacodynamic activity of transdermal patches containing captopril was evaluated in rats by the measurement of systolic blood pressure for 24 h with the use of the tail cuff method. Blood pressure, heart rate, body and heart weight, heart and body weight ratio were determined. Lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO) and Na+, K(+)-ATPase were measured in the serum of rats. Histopathological evaluation of the heart tissue was conducted in order to determine any tissue damage. Blood pressure values of the TTS containing captopril hypertension group were decreased significantly and became almost similar with the blood pressure values of the control group. These results indicated that matrix type transdermal patches prepared with Eudragit RL 100 and RS 100 polymers containing captopril can be considered as transdermal therapeutic systems for chronical treatment of hypertension and congestive heart failure. However, further in vivo pharmacokinetic studies should be performed in order to determine the blood level of the drug.

  10. The Curriculum Matrix: A Management System for Mastery Learning. [Revised].

    ERIC Educational Resources Information Center

    Squires, David A.

    The curriculum matrix is a tool to help curriculum coordinators, principals, and superintendents specify, justify, and align curriculum and instructional time to district specified standards. The problem the curriculum matrix solves is connecting the curriculum; that is, tracing an idea from initial justification to its placement in the curriculum…

  11. Stable and accurate hybrid finite volume methods based on pure convexity arguments for hyperbolic systems of conservation law

    NASA Astrophysics Data System (ADS)

    De Vuyst, Florian

    2004-01-01

    This exploratory work tries to present first results of a novel approach for the numerical approximation of solutions of hyperbolic systems of conservation laws. The objective is to define stable and "reasonably" accurate numerical schemes while being free from any upwind process and from any computation of derivatives or mean Jacobian matrices. That means that we only want to perform flux evaluations. This would be useful for "complicated" systems like those of two-phase models where solutions of Riemann problems are hard, see impossible to compute. For Riemann or Roe-like solvers, each fluid model needs the particular computation of the Jacobian matrix of the flux and the hyperbolicity property which can be conditional for some of these models makes the matrices be not R-diagonalizable everywhere in the admissible state space. In this paper, we rather propose some numerical schemes where the stability is obtained using convexity considerations. A certain rate of accuracy is also expected. For that, we propose to build numerical hybrid fluxes that are convex combinations of the second-order Lax-Wendroff scheme flux and the first-order modified Lax-Friedrichs scheme flux with an "optimal" combination rate that ensures both minimal numerical dissipation and good accuracy. The resulting scheme is a central scheme-like method. We will also need and propose a definition of local dissipation by convexity for hyperbolic or elliptic-hyperbolic systems. This convexity argument allows us to overcome the difficulty of nonexistence of classical entropy-flux pairs for certain systems. We emphasize the systematic feature of the method which can be fastly implemented or adapted to any kind of systems, with general analytical or data-tabulated equations of state. The numerical results presented in the paper are not superior to many existing state-of-the-art numerical methods for conservation laws such as ENO, MUSCL or central scheme of Tadmor and coworkers. The interest is rather

  12. Accurate crop classification using hierarchical genetic fuzzy rule-based systems

    NASA Astrophysics Data System (ADS)

    Topaloglou, Charalampos A.; Mylonas, Stelios K.; Stavrakoudis, Dimitris G.; Mastorocostas, Paris A.; Theocharis, John B.

    2014-10-01

    This paper investigates the effectiveness of an advanced classification system for accurate crop classification using very high resolution (VHR) satellite imagery. Specifically, a recently proposed genetic fuzzy rule-based classification system (GFRBCS) is employed, namely, the Hierarchical Rule-based Linguistic Classifier (HiRLiC). HiRLiC's model comprises a small set of simple IF-THEN fuzzy rules, easily interpretable by humans. One of its most important attributes is that its learning algorithm requires minimum user interaction, since the most important learning parameters affecting the classification accuracy are determined by the learning algorithm automatically. HiRLiC is applied in a challenging crop classification task, using a SPOT5 satellite image over an intensively cultivated area in a lake-wetland ecosystem in northern Greece. A rich set of higher-order spectral and textural features is derived from the initial bands of the (pan-sharpened) image, resulting in an input space comprising 119 features. The experimental analysis proves that HiRLiC compares favorably to other interpretable classifiers of the literature, both in terms of structural complexity and classification accuracy. Its testing accuracy was very close to that obtained by complex state-of-the-art classification systems, such as the support vector machines (SVM) and random forest (RF) classifiers. Nevertheless, visual inspection of the derived classification maps shows that HiRLiC is characterized by higher generalization properties, providing more homogeneous classifications that the competitors. Moreover, the runtime requirements for producing the thematic map was orders of magnitude lower than the respective for the competitors.

  13. Gold nanospikes based microsensor as a highly accurate mercury emission monitoring system

    PubMed Central

    Sabri, Ylias M.; Ippolito, Samuel J.; Tardio, James; Bansal, Vipul; O'Mullane, Anthony P.; Bhargava, Suresh K.

    2014-01-01

    Anthropogenic elemental mercury (Hg0) emission is a serious worldwide environmental problem due to the extreme toxicity of the heavy metal to humans, plants and wildlife. Development of an accurate and cheap microsensor based online monitoring system which can be integrated as part of Hg0 removal and control processes in industry is still a major challenge. Here, we demonstrate that forming Au nanospike structures directly onto the electrodes of a quartz crystal microbalance (QCM) using a novel electrochemical route results in a self-regenerating, highly robust, stable, sensitive and selective Hg0 vapor sensor. The data from a 127 day continuous test performed in the presence of volatile organic compounds and high humidity levels, showed that the sensor with an electrodeposted sensitive layer had 260% higher response magnitude, 3.4 times lower detection limit (~22 μg/m3 or ~2.46 ppbv) and higher accuracy (98% Vs 35%) over a Au control based QCM (unmodified) when exposed to a Hg0 vapor concentration of 10.55 mg/m3 at 101°C. Statistical analysis of the long term data showed that the nano-engineered Hg0 sorption sites on the developed Au nanospikes sensitive layer play a critical role in the enhanced sensitivity and selectivity of the developed sensor towards Hg0 vapor. PMID:25338965

  14. Time-Accurate Unsteady Pressure Loads Simulated for the Space Launch System at Wind Tunnel Conditions

    NASA Technical Reports Server (NTRS)

    Alter, Stephen J.; Brauckmann, Gregory J.; Kleb, William L.; Glass, Christopher E.; Streett, Craig L.; Schuster, David M.

    2015-01-01

    A transonic flow field about a Space Launch System (SLS) configuration was simulated with the Fully Unstructured Three-Dimensional (FUN3D) computational fluid dynamics (CFD) code at wind tunnel conditions. Unsteady, time-accurate computations were performed using second-order Delayed Detached Eddy Simulation (DDES) for up to 1.5 physical seconds. The surface pressure time history was collected at 619 locations, 169 of which matched locations on a 2.5 percent wind tunnel model that was tested in the 11 ft. x 11 ft. test section of the NASA Ames Research Center's Unitary Plan Wind Tunnel. Comparisons between computation and experiment showed that the peak surface pressure RMS level occurs behind the forward attach hardware, and good agreement for frequency and power was obtained in this region. Computational domain, grid resolution, and time step sensitivity studies were performed. These included an investigation of pseudo-time sub-iteration convergence. Using these sensitivity studies and experimental data comparisons, a set of best practices to date have been established for FUN3D simulations for SLS launch vehicle analysis. To the author's knowledge, this is the first time DDES has been used in a systematic approach and establish simulation time needed, to analyze unsteady pressure loads on a space launch vehicle such as the NASA SLS.

  15. Development of an accurate fluid management system for a pediatric continuous renal replacement therapy device

    PubMed Central

    SANTHANAKRISHNAN, ARVIND; NESTLE, TRENT T.; MOORE, BRIAN L.; YOGANATHAN, AJIT P.; PADEN, MATTHEW L.

    2013-01-01

    Acute kidney injury is common in critically ill children and renal replacement therapies provide a life saving therapy to a subset of these children. However, there is no Food and Drug Administration approved device to provide pediatric continuous renal replacement therapy (CRRT). Consequently, clinicians adapt approved adult CRRT devices for use in children due to lack of safer alternatives. Complications occur using adult CRRT devices in children due to inaccurate fluid balance (FB) between the volumes of ultrafiltrate (UF) removed and replacement fluid (RF) delivered. We demonstrate the design and validation of a pediatric fluid management system for obtaining accurate instantaneous and cumulative FB. Fluid transport was achieved via multiple novel pulsatile diaphragm pumps. The conservation of volume principle leveraging the physical property of fluid incompressibility along with mechanical coupling via a crankshaft was used for FB. Accuracy testing was conducted in vitro for 8-hour long continuous operation of the coupled UF and RF pumps. The mean cumulative FB error was <1% across filtration flows from 300 mL/hour to 3000 mL/hour. This approach of FB control in a pediatric specific CRRT device would represent a significant accuracy improvement over currently used clinical implementations. PMID:23644618

  16. Development of an accurate fluid management system for a pediatric continuous renal replacement therapy device.

    PubMed

    Santhanakrishnan, Arvind; Nestle, Trent T; Moore, Brian L; Yoganathan, Ajit P; Paden, Matthew L

    2013-01-01

    Acute kidney injury is common in critically ill children, and renal replacement therapies provide a life-saving therapy to a subset of these children. However, there is no Food and Drug Administration-approved device to provide pediatric continuous renal replacement therapy (CRRT). Consequently, clinicians adapt approved adult CRRT devices for use in children because of lack of safer alternatives. Complications occur using adult CRRT devices in children because of inaccurate fluid balance (FB) between the volumes of ultrafiltrate (UF) removed and replacement fluid (RF) delivered. We demonstrate the design and validation of a pediatric fluid management system for obtaining accurate instantaneous and cumulative FB. Fluid transport was achieved via multiple novel pulsatile diaphragm pumps. The conservation of volume principle leveraging the physical property of fluid incompressibility along with mechanical coupling via a crankshaft was used for FB. Accuracy testing was conducted in vitro for 8 hour long continuous operation of the coupled UF and RF pumps. The mean cumulative FB error was <1% across filtration flows from 300 to 3000 ml/hour. This approach of FB control in a pediatric-specific CRRT device would represent a significant accuracy improvement over currently used clinical implementations. PMID:23644618

  17. Modeling State-Space Aeroelastic Systems Using a Simple Matrix Polynomial Approach for the Unsteady Aerodynamics

    NASA Technical Reports Server (NTRS)

    Pototzky, Anthony S.

    2008-01-01

    A simple matrix polynomial approach is introduced for approximating unsteady aerodynamics in the s-plane and ultimately, after combining matrix polynomial coefficients with matrices defining the structure, a matrix polynomial of the flutter equations of motion (EOM) is formed. A technique of recasting the matrix-polynomial form of the flutter EOM into a first order form is also presented that can be used to determine the eigenvalues near the origin and everywhere on the complex plane. An aeroservoelastic (ASE) EOM have been generalized to include the gust terms on the right-hand side. The reasons for developing the new matrix polynomial approach are also presented, which are the following: first, the "workhorse" methods such as the NASTRAN flutter analysis lack the capability to consistently find roots near the origin, along the real axis or accurately find roots farther away from the imaginary axis of the complex plane; and, second, the existing s-plane methods, such as the Roger s s-plane approximation method as implemented in ISAC, do not always give suitable fits of some tabular data of the unsteady aerodynamics. A method available in MATLAB is introduced that will accurately fit generalized aerodynamic force (GAF) coefficients in a tabular data form into the coefficients of a matrix polynomial form. The root-locus results from the NASTRAN pknl flutter analysis, the ISAC-Roger's s-plane method and the present matrix polynomial method are presented and compared for accuracy and for the number and locations of roots.

  18. Equifinality and its violations in a redundant system: multifinger accurate force production

    PubMed Central

    Wilhelm, Luke; Zatsiorsky, Vladimir M.

    2013-01-01

    We explored a hypothesis that transient perturbations applied to a redundant system result in equifinality in the space of task-related performance variables but not in the space of elemental variables. The subjects pressed with four fingers and produced an accurate constant total force level. The “inverse piano” device was used to lift and lower one of the fingers smoothly. The subjects were instructed “not to intervene voluntarily” with possible force changes. Analysis was performed in spaces of finger forces and finger modes (hypothetical neural commands to fingers) as elemental variables. Lifting a finger led to an increase in its force and a decrease in the forces of the other three fingers; the total force increased. Lowering the finger back led to a drop in the force of the perturbed finger. At the final state, the sum of the variances of finger forces/modes computed across repetitive trials was significantly higher than the variance of the total force/mode. Most variance of the individual finger force/mode changes between the preperturbation and postperturbation states was compatible with constant total force. We conclude that a transient perturbation applied to a redundant system leads to relatively small variance in the task-related performance variable (equifinality), whereas in the space of elemental variables much more variance occurs that does not lead to total force changes. We interpret the results within a general theoretical scheme that incorporates the ideas of hierarchically organized control, control with referent configurations, synergic control, and the uncontrolled manifold hypothesis. PMID:23904497

  19. Equifinality and its violations in a redundant system: multifinger accurate force production.

    PubMed

    Wilhelm, Luke; Zatsiorsky, Vladimir M; Latash, Mark L

    2013-10-01

    We explored a hypothesis that transient perturbations applied to a redundant system result in equifinality in the space of task-related performance variables but not in the space of elemental variables. The subjects pressed with four fingers and produced an accurate constant total force level. The "inverse piano" device was used to lift and lower one of the fingers smoothly. The subjects were instructed "not to intervene voluntarily" with possible force changes. Analysis was performed in spaces of finger forces and finger modes (hypothetical neural commands to fingers) as elemental variables. Lifting a finger led to an increase in its force and a decrease in the forces of the other three fingers; the total force increased. Lowering the finger back led to a drop in the force of the perturbed finger. At the final state, the sum of the variances of finger forces/modes computed across repetitive trials was significantly higher than the variance of the total force/mode. Most variance of the individual finger force/mode changes between the preperturbation and postperturbation states was compatible with constant total force. We conclude that a transient perturbation applied to a redundant system leads to relatively small variance in the task-related performance variable (equifinality), whereas in the space of elemental variables much more variance occurs that does not lead to total force changes. We interpret the results within a general theoretical scheme that incorporates the ideas of hierarchically organized control, control with referent configurations, synergic control, and the uncontrolled manifold hypothesis. PMID:23904497

  20. System matrix for OSEM SPECT with attenuation compensation in mesh domain

    NASA Astrophysics Data System (ADS)

    Vogelsang, Levon; Krol, Andrzej; Feiglin, David H.; Lipson, Edward

    2010-04-01

    The purpose of this study was to develop and implement an accurate and computationally efficient method for determination of the mesh-domain ssssssystem matrix including attenuation compensation for Ordered Subsets Expectation Maximization (OSEM) Single Photon Emission Computed Tomography (SPECT). The mesh-domain system matrix elements were estimated by first partitioning the object domain into strips parallel to detector face and with width not exceeding the size of a detector unit. This was followed by approximating the integration over the strip/mesh-element union. This approximation is product of: (i) strip width, (ii) intersection length of a ray central to strip with a mesh element, and (iii) the response and expansion function evaluated at midpoint of the intersection length. Reconstruction was performed using OSEM without regularization and with exact knowledge of the attenuation map. The method was evaluated using synthetic SPECT data generated using SIMIND Monte Carlo simulation software. Comparative quantitative and qualitative analysis included: bias, variance, standard deviation and line-profiles within three different regions of interest. We found that no more than two divisions per detector bin were needed for good quality reconstructed images when using a high resolution mesh.

  1. Modeling of drug release from matrix systems involving moving boundaries: approximate analytical solutions.

    PubMed

    Lee, Ping I

    2011-10-10

    The purpose of this review is to provide an overview of approximate analytical solutions to the general moving boundary diffusion problems encountered during the release of a dispersed drug from matrix systems. Starting from the theoretical basis of the Higuchi equation and its subsequent improvement and refinement, available approximate analytical solutions for the more complicated cases involving heterogeneous matrix, boundary layer effect, finite release medium, surface erosion, and finite dissolution rate are also discussed. Among various modeling approaches, the pseudo-steady state assumption employed in deriving the Higuchi equation and related approximate analytical solutions appears to yield reasonably accurate results in describing the early stage release of a dispersed drug from matrices of different geometries whenever the initial drug loading (A) is much larger than the drug solubility (C(s)) in the matrix (or A≫C(s)). However, when the drug loading is not in great excess of the drug solubility (i.e. low A/C(s) values) or when the drug loading approaches the drug solubility (A→C(s)) which occurs often with drugs of high aqueous solubility, approximate analytical solutions based on the pseudo-steady state assumption tend to fail, with the Higuchi equation for planar geometry exhibiting a 11.38% error as compared with the exact solution. In contrast, approximate analytical solutions to this problem without making the pseudo-steady state assumption, based on either the double-integration refinement of the heat balance integral method or the direct simplification of available exact analytical solutions, show close agreement with the exact solutions in different geometries, particularly in the case of low A/C(s) values or drug loading approaching the drug solubility (A→C(s)). However, the double-integration heat balance integral approach is generally more useful in obtaining approximate analytical solutions especially when exact solutions are not

  2. Experimental results for improving the matrix condition using a hybrid optical system.

    PubMed

    Klapp, Iftach; Mendlovic, David

    2012-03-01

    We present preliminary experimental results for implementing the "blurred trajectories" method on three parallel optics (PO) systems. The "main" system and "auxiliary" optics were simple laboratory graded lenses attached to an iris diaphragm. When applying the blurred trajectories method we first show an improvement in the matrix condition, as the matrix condition number decreased in a range of factors of 3 to 418 relative to the main system. Following that, image restoration by weak regularization was performed so that the system matrix condition dominated the restoration process. It was shown that the restoration results of the PO are better than those of the main system and the auxiliary optics separately. In addition, the quality of the restoration follows the system's matrix condition. The improvement in the matrix condition achieved by the PO system improved the immunity to detection noise. Finally, a comparison to Wiener filtering restoration shows that it is also generally inferior to the proposed method.

  3. Matrix embedded microspherules containing indomethacin as controlled drug delivery systems.

    PubMed

    Swamy, K M Lokamatha; Satyanath, B; Shantakumar, S M; Manjula, D; Mohammedi, Hafsa; Farhana, Ayesha

    2008-10-01

    This work is focused on the development of controlled drug delivery systems using different wax/fat embedded indomethacin (IM). Discrete wax/fat embedded microspherules containing indomethacin were prepared by using cetostearyl alcohol, paraffin wax and stearic acid by employing emulsification-phase separation method. These matrices have been used as barrier coatings due to their hydrophobic nature. Chemically inert and tasteless nature of wax/fats promotes their use as taste masking agents for bitter drugs. Various waxes and fats are available having different physicochemical properties to suit the needs of formulation. Methyl cellulose (MC) 1% w/v, sodium alginate (SA) 0.5% w/v and Tween-80 (TW) 1% w/v were used as emulgents. The resulting microspherules were discrete, large, spherical and also free flowing. It is revealed from the literature that natures of wax/fat emulgents were found to influence the rate of drug release. In the present work the drug content in all the batches of microspherules were found to be uniform. The rate of drug release corresponded best to first order kinetics, followed by Higuchi and zero-order equations. The release of the model drug from these wax/fat microspherules was prolonged over an extended period of time and the drug release mechanism followed anomalous (non-Fickian) diffusion controlled as well as Super Case II transport. Among the three matrix materials used, paraffin wax retarded the drug release more than the other two. Surface characteristics of microspherules have been studied by Scanning Electron Microscope (SEM). A fair degree rank of correlation was found to exist between the size and release retardation in all the three-wax/fat emulgent combinations.

  4. A multi-radar wireless system for respiratory gating and accurate tumor tracking in lung cancer radiotherapy.

    PubMed

    Gu, Changzhan; Li, Ruijiang; Jiang, Steve B; Li, Changzhi

    2011-01-01

    Respiratory gating and tumor tracking are two promising motion-adaptive lung cancer treatments, minimizing incidence and severity of normal tissues and precisely delivering radiation dose to the tumor. Accurate respiration measurement is important in respiratory-gated radiotherapy. Conventional gating techniques are either invasive to the body or bring insufficient accuracy and discomfort to the patients. In this paper, we present an accurate noncontact means of measuring respiration for the use in gated lung cancer radiotherapy. We also present an accurate tumor tracking technique for dynamical beam tracking radiotherapy. Two 2.4 GHz miniature radars were used to monitor the chest wall and abdominal movements simultaneously to get high resolution and enhanced parameter identification. Ray tracing technique was used to investigate the impact of antenna size in clinical practice. It is shown that our multiple radar system can reliably measure respiration signals for respiratory gating and accurate tumor tracking in motion-adaptive lung cancer radiotherapy.

  5. Dry arthroscopy with a retraction system for matrix-aided cartilage repair of patellar lesions.

    PubMed

    Sadlik, Boguslaw; Wiewiorski, Martin

    2014-02-01

    Several commercially available cartilage repair techniques use a natural or synthetic matrix to aid cartilage regeneration (e.g., autologous matrix-induced chondrogenesis or matrix-induced cartilage implantation). However, the use of matrix-aided techniques during conventional knee joint arthroscopy under continuous irrigation is challenging. Insertion and fixation of the matrix can be complicated by the presence of fluid and the confined patellofemoral joint space with limited access to the lesion. To overcome these issues, we developed a novel arthroscopic approach for matrix-aided cartilage repair of patellar lesions. This technical note describes the use of dry arthroscopy assisted by a minimally invasive retraction system. An autologous matrix-induced chondrogenesis procedure is used to illustrate this novel approach.

  6. Development of a Rapid and Accurate Identification Method for Citrobacter Species Isolated from Pork Products Using a Matrix-Assisted Laser-Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS).

    PubMed

    Kwak, Hye-Lim; Han, Sun-Kyung; Park, Sunghoon; Park, Si Hong; Shim, Jae-Yong; Oh, Mihwa; Ricke, Steven C; Kim, Hae-Yeong

    2015-09-01

    Previous detection methods for Citrobacter are considered time consuming and laborious. In this study, we have developed a rapid and accurate detection method for Citrobacter species in pork products, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). A total of 35 Citrobacter strains were isolated from 30 pork products and identified by both MALDI-TOF MS and 16S rRNA gene sequencing approaches. All isolates were identified to the species level by the MALDI-TOF MS, while 16S rRNA gene sequencing results could not discriminate them clearly. These results confirmed that MALDI-TOF MS is a more accurate and rapid detection method for the identification of Citrobacter species.

  7. Matrix formulation of a universal microbial transcript profiling system

    SciTech Connect

    Fitch, J P; Ng, J; Sokhansanj, B A

    2000-11-01

    DNA chips and microarrays are used to profile gene transcription. Unfortunately, the initial fabrication cost for a chip and the reagent costs to amplify thousands of open reading frames for a microarray are over $100K for a typical 4 Mbase bacterial genome. To avoid these expensive steps, a matrix formulation of a universal hybrid chip-microarray approach to transcript profiling is demonstrated for synthetic data. Initial considerations for application to the 4.3 Mbase bacterium Yersinia pestis are also presented. This approach can be applied to arbitrary bacteria by recalculating a matrix and pseudoinverse. This approach avoids the large upfront expenses associated with DNA chips and microarrays.

  8. Accurate prediction of diradical chemistry from a single-reference density-matrix method: Model application to the bicyclobutane to gauche-1,3-butadiene isomerization

    SciTech Connect

    Bertels, Luke W.; Mazziotti, David A.

    2014-07-28

    Multireference correlation in diradical molecules can be captured by a single-reference 2-electron reduced-density-matrix (2-RDM) calculation with only single and double excitations in the 2-RDM parametrization. The 2-RDM parametrization is determined by N-representability conditions that are non-perturbative in their treatment of the electron correlation. Conventional single-reference wave function methods cannot describe the entanglement within diradical molecules without employing triple- and potentially even higher-order excitations of the mean-field determinant. In the isomerization of bicyclobutane to gauche-1,3-butadiene the parametric 2-RDM (p2-RDM) method predicts that the diradical disrotatory transition state is 58.9 kcal/mol above bicyclobutane. This barrier is in agreement with previous multireference calculations as well as recent Monte Carlo and higher-order coupled cluster calculations. The p2-RDM method predicts the Nth natural-orbital occupation number of the transition state to be 0.635, revealing its diradical character. The optimized geometry from the p2-RDM method differs in important details from the complete-active-space self-consistent-field geometry used in many previous studies including the Monte Carlo calculation.

  9. A simple but accurate potential for the naphthalene-argon complex: applications to collisional energy transfer and matrix isolated IR spectroscopy.

    PubMed

    Calvo, F; Falvo, Cyril; Parneix, Pascal

    2013-01-21

    An explicit polarizable potential for the naphthalene-argon complex has been derived assuming only atomic contributions, aiming at large scale simulations of naphthalene under argon environment. The potential was parametrized from dedicated quantum chemical calculations at the CCSD(T) level, and satisfactorily reproduces available structural and energetic properties. Combining this potential with a tight-binding model for naphthalene, collisional energy transfer is studied by means of dedicated molecular dynamics simulations, nuclear quantum effects being accounted for in the path-integral framework. Except at low target temperature, nuclear quantum effects do not alter the average energies transferred by the collision or the collision duration. However, the distribution of energy transferred is much broader in the quantum case due to the significant zero-point energy and the higher density of states. Using an ab initio potential for the Ar-Ar interaction, the IR absorption spectrum of naphthalene solvated by argon clusters or an entire Ar matrix is computed via classical and centroid molecular dynamics. The classical spectra exhibit variations with growing argon environment that are absent from quantum spectra. This is interpreted by the greater fluxional character experienced by the argon atoms due to vibrational delocalization.

  10. An accurate air temperature measurement system based on an envelope pulsed ultrasonic time-of-flight technique.

    PubMed

    Huang, Y S; Huang, Y P; Huang, K N; Young, M S

    2007-11-01

    A new microcomputer based air temperature measurement system is presented. An accurate temperature measurement is derived from the measurement of sound velocity by using an ultrasonic time-of-flight (TOF) technique. The study proposes a novel algorithm that combines both amplitude modulation (AM) and phase modulation (PM) to get the TOF measurement. The proposed system uses the AM and PM envelope square waveform (APESW) to reduce the error caused by inertia delay. The APESW ultrasonic driving waveform causes an envelope zero and phase inversion phenomenon in the relative waveform of the receiver. To accurately achieve a TOF measurement, the phase inversion phenomenon was used to sufficiently identify the measurement pulse in the received waveform. Additionally, a counter clock technique was combined to compute the phase shifts of the last incomplete cycle for TOF. The presented system can obtain 0.1% TOF resolution for the period corresponding to the 40 kHz frequency ultrasonic wave. Consequently, with the integration of a humidity compensation algorithm, a highly accurate and high resolution temperature measurement can be achieved using the accurate TOF measurement. Experimental results indicate that the combined standard uncertainty of the temperature measurement is approximately 0.39 degrees C. The main advantages of this system are high resolution measurements, narrow bandwidth requirements, and ease of implementation.

  11. Improved approximate methods for calculating frequency response function matrix and response of MDOF systems with viscoelastic hereditary terms

    NASA Astrophysics Data System (ADS)

    Li, Li; Hu, Yujin; Wang, Xuelin

    2013-07-01

    As we know, it is difficult and unnecessary to obtain all the eigenpairs of a large-scaled viscoelastic (nonviscous or hysteretic) damping systems, which means that the mode truncation scheme is generally used and the mode-truncated error is therefore introduced. This study is aimed at eliminating the influence of the unavailable modes on the dynamic response of MDOF systems with viscoelastic hereditary terms. The energy dissipation terms of the system depend on the past history of motion via convolution integrals over some kernel functions. Therefore, the system is a nonviscously damped system, which has been considered as the most generalized damping model within the scope of a linear mechanical analysis. To approximate frequency response function (FRF) matrix and response without using the unavailable modes, we suggest two methods, which attempt to approximate the influence of the unavailable modes in terms of the lower modes and system matrices by using the first one or two terms of Neumann expansion of the contribution of the unavailable modes. In contrast with the FRF matrix approximated in terms of the first two terms of Neumann expansion, these procedures cannot be extended to further high order terms since all of them will be affected by the frequency-dependent variation of damping matrix from previous terms. Finally, an example is shown that the two presented methods can make the mode-truncated error reduce and may be used to approximate the influence of nonviscous modes contributed to FRF matrix due to the fact that the nonviscous modes are difficult to be obtained accurately even if a small scaled model is used for some eigensolution methods.

  12. On Optimal Backward Perturbation Analysis for the Linear System with Skew Circulant Coefficient Matrix

    PubMed Central

    Jiang, Zhaolin; Shen, Nuo; Zhou, Jianwei

    2013-01-01

    We first give the style spectral decomposition of a special skew circulant matrix C and then get the style decomposition of arbitrary skew circulant matrix by making use of the Kronecker products between the elements of first row in skew circulant and the special skew circulant C. Besides that, we obtain the singular value of skew circulant matrix as well. Finally, we deal with the optimal backward perturbation analysis for the linear system with skew circulant coefficient matrix on the base of its style spectral decomposition. PMID:24369488

  13. Extracellular matrix-associated proteins form an integral and dynamic system during Pseudomonas aeruginosa biofilm development

    PubMed Central

    Zhang, Weipeng; Sun, Jin; Ding, Wei; Lin, Jinshui; Tian, Renmao; Lu, Liang; Liu, Xiaofen; Shen, Xihui; Qian, Pei-Yuan

    2015-01-01

    Though the essential role of extracellular matrix in biofilm development has been extensively documented, the function of matrix-associated proteins is elusive. Determining the dynamics of matrix-associated proteins would be a useful way to reveal their functions in biofilm development. Therefore, we applied iTRAQ-based quantitative proteomics to evaluate matrix-associated proteins isolated from different phases of Pseudomonas aeruginosa ATCC27853 biofilms. Among the identified 389 proteins, 54 changed their abundance significantly. The increased abundance of stress resistance and nutrient metabolism-related proteins over the period of biofilm development was consistent with the hypothesis that biofilm matrix forms micro-environments in which cells are optimally organized to resist stress and use available nutrients. Secreted proteins, including novel putative effectors of the type III secretion system were identified, suggesting that the dynamics of pathogenesis-related proteins in the matrix are associated with biofilm development. Interestingly, there was a good correlation between the abundance changes of matrix-associated proteins and their expression. Further analysis revealed complex interactions among these modulated proteins, and the mutation of selected proteins attenuated biofilm development. Collectively, this work presents the first dynamic picture of matrix-associated proteins during biofilm development, and provides evidences that the matrix-associated proteins may form an integral and well regulated system that contributes to stress resistance, nutrient acquisition, pathogenesis and the stability of the biofilm. PMID:26029669

  14. Matrix-Product-State Algorithm for Finite Fractional Quantum Hall Systems

    NASA Astrophysics Data System (ADS)

    Liu, Zhao; Bhatt, R. N.

    2015-09-01

    Exact diagonalization is a powerful tool to study fractional quantum Hall (FQH) systems. However, its capability is limited by the exponentially increasing computational cost. In order to overcome this difficulty, density-matrix-renormalization-group (DMRG) algorithms were developed for much larger system sizes. Very recently, it was realized that some model FQH states have exact matrix-product-state (MPS) representation. Motivated by this, here we report a MPS code, which is closely related to, but different from traditional DMRG language, for finite FQH systems on the cylinder geometry. By representing the many-body Hamiltonian as a matrix-product-operator (MPO) and using single-site update and density matrix correction, we show that our code can efficiently search the ground state of various FQH systems. We also compare the performance of our code with traditional DMRG. The possible generalization of our code to infinite FQH systems and other physical systems is also discussed.

  15. Automated MALDI matrix coating system for multiple tissue samples for imaging mass spectrometry.

    PubMed

    Mounfield, William P; Garrett, Timothy J

    2012-03-01

    Uniform matrix deposition on tissue samples for matrix-assisted laser desorption/ionization (MALDI) is key for reproducible analyte ion signals. Current methods often result in nonhomogenous matrix deposition, and take time and effort to produce acceptable ion signals. Here we describe a fully-automated method for matrix deposition using an enclosed spray chamber and spray nozzle for matrix solution delivery. A commercial air-atomizing spray nozzle was modified and combined with solenoid controlled valves and a Programmable Logic Controller (PLC) to control and deliver the matrix solution. A spray chamber was employed to contain the nozzle, sample, and atomized matrix solution stream, and to prevent any interference from outside conditions as well as allow complete control of the sample environment. A gravity cup was filled with MALDI matrix solutions, including DHB in chloroform/methanol (50:50) at concentrations up to 60 mg/mL. Various samples (including rat brain tissue sections) were prepared using two deposition methods (spray chamber, inkjet). A linear ion trap equipped with an intermediate-pressure MALDI source was used for analyses. Optical microscopic examination showed a uniform coating of matrix crystals across the sample. Overall, the mass spectral images gathered from tissues coated using the spray chamber system were of better quality and more reproducible than from tissue specimens prepared by the inkjet deposition method.

  16. Automated MALDI Matrix Coating System for Multiple Tissue Samples for Imaging Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Mounfield, William P.; Garrett, Timothy J.

    2012-03-01

    Uniform matrix deposition on tissue samples for matrix-assisted laser desorption/ionization (MALDI) is key for reproducible analyte ion signals. Current methods often result in nonhomogenous matrix deposition, and take time and effort to produce acceptable ion signals. Here we describe a fully-automated method for matrix deposition using an enclosed spray chamber and spray nozzle for matrix solution delivery. A commercial air-atomizing spray nozzle was modified and combined with solenoid controlled valves and a Programmable Logic Controller (PLC) to control and deliver the matrix solution. A spray chamber was employed to contain the nozzle, sample, and atomized matrix solution stream, and to prevent any interference from outside conditions as well as allow complete control of the sample environment. A gravity cup was filled with MALDI matrix solutions, including DHB in chloroform/methanol (50:50) at concentrations up to 60 mg/mL. Various samples (including rat brain tissue sections) were prepared using two deposition methods (spray chamber, inkjet). A linear ion trap equipped with an intermediate-pressure MALDI source was used for analyses. Optical microscopic examination showed a uniform coating of matrix crystals across the sample. Overall, the mass spectral images gathered from tissues coated using the spray chamber system were of better quality and more reproducible than from tissue specimens prepared by the inkjet deposition method.

  17. Three-dimensional extracellular matrix engineering in the nervous system.

    PubMed

    Borkenhagen, M; Clémence, J F; Sigrist, H; Aebischer, P

    1998-06-01

    Growing neurites are guided through their environment during development and regeneration via different cellular and extracellular matrix (ECM) molecular cues. To mimic cell-matrix interactions, a three-dimensional (3D) hydrogel-based ECM equivalent containing a covalently immobilized laminin oligopeptide sequence was designed to facilitate nerve regeneration. This study illustrates that the oligopeptide domain CDPGYIGSR covalently linked to an agarose gel as a bioartificial 3D substrate successfully supports neurite outgrowth from dorsal root ganglia (DRG) in vitro. The specificity of the neurite promoting activity was illustrated through the inhibition of neurite outgrowth from DRG in a CDPGYIGSR-derivatized gel in the presence of solubilized CDPGYIGSR peptide. Gels derivatized with CDPGYIGSK and CDPGRGSYI peptides stimulated a smaller increase of neurite outgrowth. In vivo experiments revealed the capability of a CDPGYIGSR-derivatized gel to enhance nerve regeneration in a transected rat dorsal root model compared to an underivatized gel, a CDPGRGSYI gel, and saline-filled nerve guidance channels. These data suggest the feasibility of a 3D hydrogel-based ECM equivalent capable of enhancing neurite outgrowth in vitro and in vivo.

  18. Efficient model reduction of parametrized systems by matrix discrete empirical interpolation

    NASA Astrophysics Data System (ADS)

    Negri, Federico; Manzoni, Andrea; Amsallem, David

    2015-12-01

    In this work, we apply a Matrix version of the so-called Discrete Empirical Interpolation (MDEIM) for the efficient reduction of nonaffine parametrized systems arising from the discretization of linear partial differential equations. Dealing with affinely parametrized operators is crucial in order to enhance the online solution of reduced-order models (ROMs). However, in many cases such an affine decomposition is not readily available, and must be recovered through (often) intrusive procedures, such as the empirical interpolation method (EIM) and its discrete variant DEIM. In this paper we show that MDEIM represents a very efficient approach to deal with complex physical and geometrical parametrizations in a non-intrusive, efficient and purely algebraic way. We propose different strategies to combine MDEIM with a state approximation resulting either from a reduced basis greedy approach or Proper Orthogonal Decomposition. A posteriori error estimates accounting for the MDEIM error are also developed in the case of parametrized elliptic and parabolic equations. Finally, the capability of MDEIM to generate accurate and efficient ROMs is demonstrated on the solution of two computationally-intensive classes of problems occurring in engineering contexts, namely PDE-constrained shape optimization and parametrized coupled problems.

  19. A non-empirical, parameter-free, hybrid functional for accurate calculations of optoelectronic properties of finite systems

    NASA Astrophysics Data System (ADS)

    Brawand, Nicholas; Vörös, Márton; Govoni, Marco; Galli, Giulia

    The accurate prediction of optoelectronic properties of molecules and solids is a persisting challenge for current density functional theory (DFT) based methods. We propose a hybrid functional where the mixing fraction of exact and local exchange is determined by a non-empirical, system dependent function. This functional yields ionization potentials, fundamental and optical gaps of many, diverse systems in excellent agreement with experiments, including organic and inorganic molecules and nanocrystals. We further demonstrate that the newly defined hybrid functional gives the correct alignment between the energy level of the exemplary TTF-TCNQ donor-acceptor system. DOE-BES: DE-FG02-06ER46262.

  20. Invited article: Time accurate mass flow measurements of solid-fueled systems.

    PubMed

    Olliges, Jordan D; Lilly, Taylor C; Joslyn, Thomas B; Ketsdever, Andrew D

    2008-10-01

    A novel diagnostic method is described that utilizes a thrust stand mass balance (TSMB) to directly measure time-accurate mass flow from a solid-fuel thruster. The accuracy of the TSMB mass flow measurement technique was demonstrated in three ways including the use of an idealized numerical simulation, verifying a fluid mass calibration with high-speed digital photography, and by measuring mass loss in more than 30 hybrid rocket motor firings. Dynamic response of the mass balance was assessed through weight calibration and used to derive spring, damping, and mass moment of inertia coefficients for the TSMB. These dynamic coefficients were used to determine the mass flow rate and total mass loss within an acrylic and gaseous oxygen hybrid rocket motor firing. Intentional variations in the oxygen flow rate resulted in corresponding variations in the total propellant mass flow as expected. The TSMB was optimized to determine mass losses of up to 2.5 g and measured total mass loss to within 2.5% of that calculated by a NIST-calibrated digital scale. Using this method, a mass flow resolution of 0.0011 g/s or 2% of the average mass flow in this study has been achieved.

  1. Accurate heteronuclear J-coupling measurements in dilute spin systems using the multiple-quantum filtered J-resolved experiment.

    PubMed

    Martineau, Charlotte; Fayon, Franck; Legein, Christophe; Buzaré, Jean-Yves; Silly, Gilles; Massiot, Dominique

    2007-07-14

    A new solid-state MAS NMR experiment is proposed to accurately measure heteronuclear (19)F-(207)Pb J-coupling constants, even though these couplings are not visible on high speed (19)F 1D MAS spectra; in particular, we demonstrate that the J-resolved experiment combined with scalar multiple-quantum filtering considerably improves the resolution of J-multiplet patterns for dilute spin systems. PMID:17594032

  2. Accurate description of the optical response of a multilayered spherical system in the long wavelength approximation

    NASA Astrophysics Data System (ADS)

    Chung, H. Y.; Guo, G. Y.; Chiang, H.-P.; Tsai, D. P.; Leung, P. T.

    2010-10-01

    The optical response of a multilayered spherical system of unlimited number of layers (a “matryushka”) in the long wavelength limit can be accounted for from the knowledge of the static multipole polarizability of the system to first-order accuracy. However, for systems of ultrasmall dimensions or systems with sizes not-too-small compared to the wavelength, this ordinary quasistatic long wavelength approximation (LWA) becomes inaccurate. Here we introduce two significant modifications of the LWA for such a nanomatryushka in each of the two limits: the nonlocal optical response for ultrasmall systems (<10nm) , and the “finite-wavelength corrections” for systems ˜100nm . This is accomplished by employing the previous work for a single-layer shell, in combination with a certain effective-medium approach formulated recently in the literature. Numerical calculations for the extinction cross sections for such a system of different dimensions are provided as illustrations for these effects. This formulation thus provides significant improvements on the ordinary LWA, yielding enough accuracy for the description of the optical response of these nanoshell systems over an appreciable range of sizes, without resorting to more involved quantum mechanical or fully electrodynamic calculations.

  3. Automated system for fast and accurate analysis of SF6 injected in the surface ocean.

    PubMed

    Koo, Chul-Min; Lee, Kitack; Kim, Miok; Kim, Dae-Ok

    2005-11-01

    This paper describes an automated sampling and analysis system for the shipboard measurement of dissolved sulfur hexafluoride (SF6) in surface marine environments into which SF6 has been deliberately released. This underway system includes a gas chromatograph associated with an electron capture detector, a fast and highly efficient SF6-extraction device, a global positioning system, and a data acquisition system based on Visual Basic 6.0/C 6.0. This work is distinct from previous studies in that it quantifies the efficiency of the SF6-extraction device and its carryover effect and examines the effect of surfactant on the SF6-extraction efficiency. Measurements can be continuously performed on seawater samples taken from a seawater line installed onboard a research vessel. The system runs on an hourly cycle during which one set of four SF6 standards is measured and SF6 derived from the seawater stream is subsequently analyzed for the rest of each 1 h period. This state-of-art system was successfully used to trace a water mass carrying Cochlodinium polykrikoides, which causes harmful algal blooms (HAB) in the coastal waters of southern Korea. The successful application of this analysis system in tracing the HAB-infected water mass suggests that the SF6 detection method described in this paper will improve the quality of the future study of biogeochemical processes in the marine environment. PMID:16294883

  4. Automated system for fast and accurate analysis of SF6 injected in the surface ocean.

    PubMed

    Koo, Chul-Min; Lee, Kitack; Kim, Miok; Kim, Dae-Ok

    2005-11-01

    This paper describes an automated sampling and analysis system for the shipboard measurement of dissolved sulfur hexafluoride (SF6) in surface marine environments into which SF6 has been deliberately released. This underway system includes a gas chromatograph associated with an electron capture detector, a fast and highly efficient SF6-extraction device, a global positioning system, and a data acquisition system based on Visual Basic 6.0/C 6.0. This work is distinct from previous studies in that it quantifies the efficiency of the SF6-extraction device and its carryover effect and examines the effect of surfactant on the SF6-extraction efficiency. Measurements can be continuously performed on seawater samples taken from a seawater line installed onboard a research vessel. The system runs on an hourly cycle during which one set of four SF6 standards is measured and SF6 derived from the seawater stream is subsequently analyzed for the rest of each 1 h period. This state-of-art system was successfully used to trace a water mass carrying Cochlodinium polykrikoides, which causes harmful algal blooms (HAB) in the coastal waters of southern Korea. The successful application of this analysis system in tracing the HAB-infected water mass suggests that the SF6 detection method described in this paper will improve the quality of the future study of biogeochemical processes in the marine environment.

  5. Hardware and Software Developments for the Accurate Time-Linked Data Acquisition System

    SciTech Connect

    BERG,DALE E.; RUMSEY,MARK A.; ZAYAS,JOSE R.

    1999-11-09

    Wind-energy researchers at Sandia National Laboratories have developed a new, light-weight, modular data acquisition system capable of acquiring long-term, continuous, multi-channel time-series data from operating wind-turbines. New hardware features have been added to this system to make it more flexible and permit programming via telemetry. User-friendly Windows-based software has been developed for programming the hardware and acquiring, storing, analyzing, and archiving the data. This paper briefly reviews the major components of the system, summarizes the recent hardware enhancements and operating experiences, and discusses the features and capabilities of the software programs that have been developed.

  6. Computer-implemented system and method for automated and highly accurate plaque analysis, reporting, and visualization

    NASA Technical Reports Server (NTRS)

    Kemp, James Herbert (Inventor); Talukder, Ashit (Inventor); Lambert, James (Inventor); Lam, Raymond (Inventor)

    2008-01-01

    A computer-implemented system and method of intra-oral analysis for measuring plaque removal is disclosed. The system includes hardware for real-time image acquisition and software to store the acquired images on a patient-by-patient basis. The system implements algorithms to segment teeth of interest from surrounding gum, and uses a real-time image-based morphing procedure to automatically overlay a grid onto each segmented tooth. Pattern recognition methods are used to classify plaque from surrounding gum and enamel, while ignoring glare effects due to the reflection of camera light and ambient light from enamel regions. The system integrates these components into a single software suite with an easy-to-use graphical user interface (GUI) that allows users to do an end-to-end run of a patient record, including tooth segmentation of all teeth, grid morphing of each segmented tooth, and plaque classification of each tooth image.

  7. Mathematical model accurately predicts protein release from an affinity-based delivery system.

    PubMed

    Vulic, Katarina; Pakulska, Malgosia M; Sonthalia, Rohit; Ramachandran, Arun; Shoichet, Molly S

    2015-01-10

    Affinity-based controlled release modulates the delivery of protein or small molecule therapeutics through transient dissociation/association. To understand which parameters can be used to tune release, we used a mathematical model based on simple binding kinetics. A comprehensive asymptotic analysis revealed three characteristic regimes for therapeutic release from affinity-based systems. These regimes can be controlled by diffusion or unbinding kinetics, and can exhibit release over either a single stage or two stages. This analysis fundamentally changes the way we think of controlling release from affinity-based systems and thereby explains some of the discrepancies in the literature on which parameters influence affinity-based release. The rate of protein release from affinity-based systems is determined by the balance of diffusion of the therapeutic agent through the hydrogel and the dissociation kinetics of the affinity pair. Equations for tuning protein release rate by altering the strength (KD) of the affinity interaction, the concentration of binding ligand in the system, the rate of dissociation (koff) of the complex, and the hydrogel size and geometry, are provided. We validated our model by collapsing the model simulations and the experimental data from a recently described affinity release system, to a single master curve. Importantly, this mathematical analysis can be applied to any single species affinity-based system to determine the parameters required for a desired release profile. PMID:25449806

  8. Linear matrix inequalities for analysis and control of linear vector second-order systems

    SciTech Connect

    Adegas, Fabiano D.; Stoustrup, Jakob

    2014-10-06

    Many dynamical systems are modeled as vector second-order differential equations. This paper presents analysis and synthesis conditions in terms of LMI with explicit dependence in the coefficient matrices of vector second-order systems. These conditions benefit from the separation between the Lyapunov matrix and the system matrices by introducing matrix multipliers, which potentially reduce conservativeness in hard control problems. Multipliers facilitate the usage of parameter-dependent Lyapunov functions as certificates of stability of uncertain and time-varying vector second-order systems. The conditions introduced in this work have the potential to increase the practice of analyzing and controlling systems directly in vector second-order form.

  9. Accurate prediction of V1 location from cortical folds in a surface coordinate system

    PubMed Central

    Hinds, Oliver P.; Rajendran, Niranjini; Polimeni, Jonathan R.; Augustinack, Jean C.; Wiggins, Graham; Wald, Lawrence L.; Rosas, H. Diana; Potthast, Andreas; Schwartz, Eric L.; Fischl, Bruce

    2008-01-01

    Previous studies demonstrated substantial variability of the location of primary visual cortex (V1) in stereotaxic coordinates when linear volume-based registration is used to match volumetric image intensities (Amunts et al., 2000). However, other qualitative reports of V1 location (Smith, 1904; Stensaas et al., 1974; Rademacher et al., 1993) suggested a consistent relationship between V1 and the surrounding cortical folds. Here, the relationship between folds and the location of V1 is quantified using surface-based analysis to generate a probabilistic atlas of human V1. High-resolution (about 200 μm) magnetic resonance imaging (MRI) at 7 T of ex vivo human cerebral hemispheres allowed identification of the full area via the stria of Gennari: a myeloarchitectonic feature specific to V1. Separate, whole-brain scans were acquired using MRI at 1.5 T to allow segmentation and mesh reconstruction of the cortical gray matter. For each individual, V1 was manually identified in the high-resolution volume and projected onto the cortical surface. Surface-based intersubject registration (Fischl et al., 1999b) was performed to align the primary cortical folds of individual hemispheres to those of a reference template representing the average folding pattern. An atlas of V1 location was constructed by computing the probability of V1 inclusion for each cortical location in the template space. This probabilistic atlas of V1 exhibits low prediction error compared to previous V1 probabilistic atlases built in volumetric coordinates. The increased predictability observed under surface-based registration suggests that the location of V1 is more accurately predicted by the cortical folds than by the shape of the brain embedded in the volume of the skull. In addition, the high quality of this atlas provides direct evidence that surface-based intersubject registration methods are superior to volume-based methods at superimposing functional areas of cortex, and therefore are better

  10. Accurate and portable weigh-in-motion system for manifesting air cargo

    NASA Astrophysics Data System (ADS)

    Nodine, Robert N.; Scudiere, Matthew B.; Jordan, John K.

    1995-12-01

    An automated and portable weigh-in-motion system has been developed at Oak Ridge National Laboratory for the purpose of manifesting cargo onto aircraft. The system has an accuracy range of plus or minus 3.0% to plus or minus 6.0% measuring gross vehicle weight and locating the center of balance of moving vehicles at speeds of 1 to 5 mph. This paper reviews the control/user interface system and weight determination algorithm developed to acquire, process, and interpret multiple sensor inputs. The development effort resulted in a self- zeroing, user-friendly system capable of weighing a wide range of vehicles in any random order. The control system is based on the STANDARD (STD) bus and incorporates custom- designed data acquisition and sensor fusion hardware controlled by a personal computer (PC) based single-board computer. The user interface is written in the 'C' language to display number of axles, axle weight, axle spacing, gross weight, and center of balance. The weighing algorithm developed functions with any linear weight sensor and a set of four axle switches per sensor.

  11. A polymer visualization system with accurate heating and cooling control and high-speed imaging.

    PubMed

    Wong, Anson; Guo, Yanting; Park, Chul B; Zhou, Nan Q

    2015-04-23

    A visualization system to observe crystal and bubble formation in polymers under high temperature and pressure has been developed. Using this system, polymer can be subjected to a programmable thermal treatment to simulate the process in high pressure differential scanning calorimetry (HPDSC). With a high-temperature/high-pressure view-cell unit, this system enables in situ observation of crystal formation in semi-crystalline polymers to complement thermal analyses with HPDSC. The high-speed recording capability of the camera not only allows detailed recording of crystal formation, it also enables in situ capture of plastic foaming processes with a high temporal resolution. To demonstrate the system's capability, crystal formation and foaming processes of polypropylene/carbon dioxide systems were examined. It was observed that crystals nucleated and grew into spherulites, and they grew at faster rates as temperature decreased. This observation agrees with the crystallinity measurement obtained with the HPDSC. Cell nucleation first occurred at crystals' boundaries due to CO₂ exclusion from crystal growth fronts. Subsequently, cells were nucleated around the existing ones due to tensile stresses generated in the constrained amorphous regions between networks of crystals.

  12. Statistically accurate low-order models for uncertainty quantification in turbulent dynamical systems

    PubMed Central

    Sapsis, Themistoklis P.; Majda, Andrew J.

    2013-01-01

    A framework for low-order predictive statistical modeling and uncertainty quantification in turbulent dynamical systems is developed here. These reduced-order, modified quasilinear Gaussian (ROMQG) algorithms apply to turbulent dynamical systems in which there is significant linear instability or linear nonnormal dynamics in the unperturbed system and energy-conserving nonlinear interactions that transfer energy from the unstable modes to the stable modes where dissipation occurs, resulting in a statistical steady state; such turbulent dynamical systems are ubiquitous in geophysical and engineering turbulence. The ROMQG method involves constructing a low-order, nonlinear, dynamical system for the mean and covariance statistics in the reduced subspace that has the unperturbed statistics as a stable fixed point and optimally incorporates the indirect effect of non-Gaussian third-order statistics for the unperturbed system in a systematic calibration stage. This calibration procedure is achieved through information involving only the mean and covariance statistics for the unperturbed equilibrium. The performance of the ROMQG algorithm is assessed on two stringent test cases: the 40-mode Lorenz 96 model mimicking midlatitude atmospheric turbulence and two-layer baroclinic models for high-latitude ocean turbulence with over 125,000 degrees of freedom. In the Lorenz 96 model, the ROMQG algorithm with just a single mode captures the transient response to random or deterministic forcing. For the baroclinic ocean turbulence models, the inexpensive ROMQG algorithm with 252 modes, less than 0.2% of the total, captures the nonlinear response of the energy, the heat flux, and even the one-dimensional energy and heat flux spectra. PMID:23918398

  13. Energy density matrix formalism for interacting quantum systems: Quantum Monte Carlo study

    NASA Astrophysics Data System (ADS)

    Krogel, Jaron T.; Kim, Jeongnim; Reboredo, Fernando A.

    2014-07-01

    We develop an energy density matrix that parallels the one-body reduced density matrix (1RDM) for many-body quantum systems. Just as the density matrix gives access to the number density and occupation numbers, the energy density matrix yields the energy density and orbital occupation energies. The eigenvectors of the matrix provide a natural orbital partitioning of the energy density while the eigenvalues comprise a single-particle energy spectrum obeying a total energy sum rule. For mean-field systems the energy density matrix recovers the exact spectrum. When correlation becomes important, the occupation energies resemble quasiparticle energies in some respects. We explore the occupation energy spectrum for the finite 3D homogeneous electron gas in the metallic regime and an isolated oxygen atom with ground-state quantum Monte Carlo techniques implemented in the qmcpack simulation code. The occupation energy spectrum for the homogeneous electron gas can be described by an effective mass below the Fermi level. Above the Fermi level evanescent behavior in the occupation energies is observed in similar fashion to the occupation numbers of the 1RDM. A direct comparison with total energy differences shows a quantitative connection between the occupation energies and electron addition and removal energies for the electron gas. For the oxygen atom, the association between the ground-state occupation energies and particle addition and removal energies becomes only qualitative. The energy density matrix provides an avenue for describing energetics with quantum Monte Carlo methods which have traditionally been limited to total energies.

  14. Of Needles and Haystacks: Building an Accurate Statewide Dropout Early Warning System in Wisconsin

    ERIC Educational Resources Information Center

    Knowles, Jared E.

    2015-01-01

    The state of Wisconsin has one of the highest four year graduation rates in the nation, but deep disparities among student subgroups remain. To address this the state has created the Wisconsin Dropout Early Warning System (DEWS), a predictive model of student dropout risk for students in grades six through nine. The Wisconsin DEWS is in use…

  15. Accurate parameters of the oldest known rocky-exoplanet hosting system: Kepler-10 revisited

    SciTech Connect

    Fogtmann-Schulz, Alexandra; Hinrup, Brian; Van Eylen, Vincent; Christensen-Dalsgaard, Jørgen; Kjeldsen, Hans; Silva Aguirre, Víctor; Tingley, Brandon

    2014-02-01

    Since the discovery of Kepler-10, the system has received considerable interest because it contains a small, rocky planet which orbits the star in less than a day. The system's parameters, announced by the Kepler team and subsequently used in further research, were based on only five months of data. We have reanalyzed this system using the full span of 29 months of Kepler photometric data, and obtained improved information about its star and the planets. A detailed asteroseismic analysis of the extended time series provides a significant improvement on the stellar parameters: not only can we state that Kepler-10 is the oldest known rocky-planet-harboring system at 10.41 ± 1.36 Gyr, but these parameters combined with improved planetary parameters from new transit fits gives us the radius of Kepler-10b to within just 125 km. A new analysis of the full planetary phase curve leads to new estimates on the planetary temperature and albedo, which remain degenerate in the Kepler band. Our modeling suggests that the flux level during the occultation is slightly lower than at the transit wings, which would imply that the nightside of this planet has a non-negligible temperature.

  16. A Polymer Visualization System with Accurate Heating and Cooling Control and High-Speed Imaging

    PubMed Central

    Wong, Anson; Guo, Yanting; Park, Chul B.; Zhou, Nan Q.

    2015-01-01

    A visualization system to observe crystal and bubble formation in polymers under high temperature and pressure has been developed. Using this system, polymer can be subjected to a programmable thermal treatment to simulate the process in high pressure differential scanning calorimetry (HPDSC). With a high-temperature/high-pressure view-cell unit, this system enables in situ observation of crystal formation in semi-crystalline polymers to complement thermal analyses with HPDSC. The high-speed recording capability of the camera not only allows detailed recording of crystal formation, it also enables in situ capture of plastic foaming processes with a high temporal resolution. To demonstrate the system’s capability, crystal formation and foaming processes of polypropylene/carbon dioxide systems were examined. It was observed that crystals nucleated and grew into spherulites, and they grew at faster rates as temperature decreased. This observation agrees with the crystallinity measurement obtained with the HPDSC. Cell nucleation first occurred at crystals’ boundaries due to CO2 exclusion from crystal growth fronts. Subsequently, cells were nucleated around the existing ones due to tensile stresses generated in the constrained amorphous regions between networks of crystals. PMID:25915031

  17. A hybrid finite element-transfer matrix model for vibroacoustic systems with flat and homogeneous acoustic treatments.

    PubMed

    Alimonti, Luca; Atalla, Noureddine; Berry, Alain; Sgard, Franck

    2015-02-01

    Practical vibroacoustic systems involve passive acoustic treatments consisting of highly dissipative media such as poroelastic materials. The numerical modeling of such systems at low to mid frequencies typically relies on substructuring methodologies based on finite element models. Namely, the master subsystems (i.e., structural and acoustic domains) are described by a finite set of uncoupled modes, whereas condensation procedures are typically preferred for the acoustic treatments. However, although accurate, such methodology is computationally expensive when real life applications are considered. A potential reduction of the computational burden could be obtained by approximating the effect of the acoustic treatment on the master subsystems without introducing physical degrees of freedom. To do that, the treatment has to be assumed homogeneous, flat, and of infinite lateral extent. Under these hypotheses, simple analytical tools like the transfer matrix method can be employed. In this paper, a hybrid finite element-transfer matrix methodology is proposed. The impact of the limiting assumptions inherent within the analytical framework are assessed for the case of plate-cavity systems involving flat and homogeneous acoustic treatments. The results prove that the hybrid model can capture the qualitative behavior of the vibroacoustic system while reducing the computational effort.

  18. A new sensor system for accurate and precise determination of sediment dynamics and position.

    NASA Astrophysics Data System (ADS)

    Maniatis, Georgios; Hoey, Trevor; Sventek, Joseph; Hodge, Rebecca

    2014-05-01

    Sediment transport processes control many significant geomorphological changes. Consequently, sediment transport dynamics are studied across a wide range of scales leading to application of a variety of conceptually different mathematical descriptions (models) and data acquisition techniques (sensing). For river sediment transport processes both Eulerian and Lagrangian formulations are used. Data are gathered using a very wide range of sensing techniques that are not always compatible with the conceptual formulation applied. We are concerned with small to medium sediment grain-scale motion in gravel-bed rivers, and other coarse-grained environments, and: a) are developing a customised environmental sensor capable of providing coherent data that reliably record the motion; and, b) provide a mathematical framework in which these data can be analysed and interpreted, this being compatible with current stochastic approaches to sediment transport theory. Here we present results from three different aspects of the above developmental process. Firstly, we present a requirement analysis for the sensor based on the state of the art of the existing technologies. We focus on the factors that enhance data coherence and representativeness, extending the common practice for optimization which is based exclusively on electronics/computing related criteria. This analysis leads to formalization of a method that permits accurate control on the physical properties of the sensor using contemporary rapid prototyping techniques [Maniatis et al. 2013]. Secondly the first results are presented from a series of entrainment experiments in a 5 x 0.8 m flume in which a prototype sensor was deployed to monitor entrainment dynamics under increasing flow conditions (0.037 m3.s-1). The sensor was enclosed in an idealized spherical case (111 mm diameter) and placed on a constructed bed of hemispheres of the same diameter. We measured 3-axial inertial acceleration (as a measure of flow stress

  19. Diagnostic efficiency of Mueller-matrix polarization reconstruction system of the phase structure of liver tissue

    NASA Astrophysics Data System (ADS)

    Zabolotna, Natalia I.; Pavlov, Sergii V.; Radchenko, Kostiantyn O.; Stasenko, Vladyslav A.; Wójcik, Waldemar; Kussambayeva, Nazym

    2015-12-01

    The application field of using the Mueller-matrix polarizing reconstruction system of phase structure of biological layer for optical-anisotropic parameters differentiation of histological sections of healthy and rat's liver with hepatitis were investigated. Comparison of system informativity with known systems on indexes of sensitivity, specificity and balanced accuracy were performed.

  20. Accurate DOSY measure for out-of-equilibrium systems using permutated DOSY (p-DOSY).

    PubMed

    Oikonomou, Maria; Asencio-Hernández, Julia; Velders, Aldrik H; Delsuc, Marc-André

    2015-09-01

    NMR spectroscopy is a excellent tool for monitoring in-situ chemical reactions. In particular, DOSY measurement is well suited to characterize transient species by the determination of their sizes. However, here we bring to light a difficulty in the DOSY experiments performed in out-of-equilibrium systems. On such a system, the evolution of the concentration of species interferes with the measurement process, and creates a bias on the diffusion coefficient determination that may lead to erroneous interpretations. We show that a random permutation of the series of gradient strengths used during the DOSY experiment allows to average out this bias. This approach, that we name p-DOSY does not require changes in the pulse sequences nor in the processing software, and restores completely the full accuracy of the measure. This technique is demonstrated on the monitoring of the anomerization reaction of α- to β-glucose.

  1. A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system

    PubMed Central

    Metcalf, Jessica L; Wegener Parfrey, Laura; Gonzalez, Antonio; Lauber, Christian L; Knights, Dan; Ackermann, Gail; Humphrey, Gregory C; Gebert, Matthew J; Van Treuren, Will; Berg-Lyons, Donna; Keepers, Kyle; Guo, Yan; Bullard, James; Fierer, Noah; Carter, David O; Knight, Rob

    2013-01-01

    Establishing the time since death is critical in every death investigation, yet existing techniques are susceptible to a range of errors and biases. For example, forensic entomology is widely used to assess the postmortem interval (PMI), but errors can range from days to months. Microbes may provide a novel method for estimating PMI that avoids many of these limitations. Here we show that postmortem microbial community changes are dramatic, measurable, and repeatable in a mouse model system, allowing PMI to be estimated within approximately 3 days over 48 days. Our results provide a detailed understanding of bacterial and microbial eukaryotic ecology within a decomposing corpse system and suggest that microbial community data can be developed into a forensic tool for estimating PMI. DOI: http://dx.doi.org/10.7554/eLife.01104.001 PMID:24137541

  2. Evaluation of a low-cost and accurate ocean temperature logger on subsurface mooring systems

    SciTech Connect

    Tian, Chuan; Deng, Zhiqun; Lu, Jun; Xu, Xiaoyang; Zhao, Wei; Xu, Ming

    2014-06-23

    Monitoring seawater temperature is important to understanding evolving ocean processes. To monitor internal waves or ocean mixing, a large number of temperature loggers are typically mounted on subsurface mooring systems to obtain high-resolution temperature data at different water depths. In this study, we redesigned and evaluated a compact, low-cost, self-contained, high-resolution and high-accuracy ocean temperature logger, TC-1121. The newly designed TC-1121 loggers are smaller, more robust, and their sampling intervals can be automatically changed by indicated events. They have been widely used in many mooring systems to study internal wave and ocean mixing. The logger’s fundamental design, noise analysis, calibration, drift test, and a long-term sea trial are discussed in this paper.

  3. Automated Mobile System for Accurate Outdoor Tree Crop Enumeration Using an Uncalibrated Camera

    PubMed Central

    Nguyen, Thuy Tuong; Slaughter, David C.; Hanson, Bradley D.; Barber, Andrew; Freitas, Amy; Robles, Daniel; Whelan, Erin

    2015-01-01

    This paper demonstrates an automated computer vision system for outdoor tree crop enumeration in a seedling nursery. The complete system incorporates both hardware components (including an embedded microcontroller, an odometry encoder, and an uncalibrated digital color camera) and software algorithms (including microcontroller algorithms and the proposed algorithm for tree crop enumeration) required to obtain robust performance in a natural outdoor environment. The enumeration system uses a three-step image analysis process based upon: (1) an orthographic plant projection method integrating a perspective transform with automatic parameter estimation; (2) a plant counting method based on projection histograms; and (3) a double-counting avoidance method based on a homography transform. Experimental results demonstrate the ability to count large numbers of plants automatically with no human effort. Results show that, for tree seedlings having a height up to 40 cm and a within-row tree spacing of approximately 10 cm, the algorithms successfully estimated the number of plants with an average accuracy of 95.2% for trees within a single image and 98% for counting of the whole plant population in a large sequence of images. PMID:26225982

  4. When do perturbative approaches accurately capture the dynamics of complex quantum systems?

    NASA Astrophysics Data System (ADS)

    Fruchtman, Amir; Lambert, Neill; Gauger, Erik M.

    2016-06-01

    Understanding the dynamics of higher-dimensional quantum systems embedded in a complex environment remains a significant theoretical challenge. While several approaches yielding numerically converged solutions exist, these are computationally expensive and often provide only limited physical insight. Here we address the question: when do more intuitive and simpler-to-compute second-order perturbative approaches provide adequate accuracy? We develop a simple analytical criterion and verify its validity for the case of the much-studied FMO dynamics as well as the canonical spin-boson model.

  5. When do perturbative approaches accurately capture the dynamics of complex quantum systems?

    PubMed Central

    Fruchtman, Amir; Lambert, Neill; Gauger, Erik M.

    2016-01-01

    Understanding the dynamics of higher-dimensional quantum systems embedded in a complex environment remains a significant theoretical challenge. While several approaches yielding numerically converged solutions exist, these are computationally expensive and often provide only limited physical insight. Here we address the question: when do more intuitive and simpler-to-compute second-order perturbative approaches provide adequate accuracy? We develop a simple analytical criterion and verify its validity for the case of the much-studied FMO dynamics as well as the canonical spin-boson model. PMID:27335176

  6. NIBBS-Search for Fast and Accurate Prediction of Phenotype-Biased Metabolic Systems

    PubMed Central

    Padmanabhan, Kanchana; Shpanskaya, Yekaterina; Banfield, Jill; Scott, Kathleen; Mihelcic, James R.; Samatova, Nagiza F.

    2012-01-01

    Understanding of genotype-phenotype associations is important not only for furthering our knowledge on internal cellular processes, but also essential for providing the foundation necessary for genetic engineering of microorganisms for industrial use (e.g., production of bioenergy or biofuels). However, genotype-phenotype associations alone do not provide enough information to alter an organism's genome to either suppress or exhibit a phenotype. It is important to look at the phenotype-related genes in the context of the genome-scale network to understand how the genes interact with other genes in the organism. Identification of metabolic subsystems involved in the expression of the phenotype is one way of placing the phenotype-related genes in the context of the entire network. A metabolic system refers to a metabolic network subgraph; nodes are compounds and edges labels are the enzymes that catalyze the reaction. The metabolic subsystem could be part of a single metabolic pathway or span parts of multiple pathways. Arguably, comparative genome-scale metabolic network analysis is a promising strategy to identify these phenotype-related metabolic subsystems. Network Instance-Based Biased Subgraph Search (NIBBS) is a graph-theoretic method for genome-scale metabolic network comparative analysis that can identify metabolic systems that are statistically biased toward phenotype-expressing organismal networks. We set up experiments with target phenotypes like hydrogen production, TCA expression, and acid-tolerance. We show via extensive literature search that some of the resulting metabolic subsystems are indeed phenotype-related and formulate hypotheses for other systems in terms of their role in phenotype expression. NIBBS is also orders of magnitude faster than MULE, one of the most efficient maximal frequent subgraph mining algorithms that could be adjusted for this problem. Also, the set of phenotype-biased metabolic systems output by NIBBS comes very close to

  7. RiboTALE: A modular, inducible system for accurate gene expression control

    PubMed Central

    Rai, Navneet; Ferreiro, Aura; Neckelmann, Alexander; Soon, Amy; Yao, Andrew; Siegel, Justin; Facciotti, Marc T.; Tagkopoulos, Ilias

    2015-01-01

    A limiting factor in synthetic gene circuit design is the number of independent control elements that can be combined together in a single system. Here, we present RiboTALEs, a new class of inducible repressors that combine the specificity of TALEs with the ability of riboswitches to recognize exogenous signals and differentially control protein abundance. We demonstrate the capacity of RiboTALEs, constructed through different combinations of TALE proteins and riboswitches, to rapidly and reproducibly control the expression of downstream targets with a dynamic range of 243.7 ± 17.6-fold, which is adequate for many biotechnological applications. PMID:26023068

  8. Gas sampling system for matrix of semiconductor gas sensors

    NASA Astrophysics Data System (ADS)

    Jasinski, Grzegorz; Strzelczyk, Anna; Koscinski, Piotr

    2016-01-01

    Semiconductor gas sensors are popular commercial sensors applied in numerous gas detection systems. They are reliable, small, rugged and inexpensive. However, there are a few problem limiting the wider use of such sensors. Semiconductor gas sensor usually exhibits a low selectivity, low repeatability, drift of response, strong temperature and moisture influence on sensor properties. Sample flow rate is one of the parameters that influence sensors response what should be considered in the measurement system. This paper describes low cost module for controlling measured gas flow rate. The proposed equipment will be used as a component of electronic nose system employed for classifying and distinguishing different levels of contamination in air.

  9. Calcium alginate gel as encapsulation matrix for coimmobilized enzyme systems.

    PubMed

    Blandino, A; Macías, M; Cantero, D

    2003-07-01

    Encapsulation within calcium alginate gel capsules was used to produce a coimmobilized enzyme system. Glucose oxidase (GOD) and catalase (CAT) were chosen as model enzymes. The same values of Vmax and Km app for the GOD encapsulated system and for the GOD-CAT coencapsulated system were calculated. When gel beads and capsules were compared, the same catalyst deactivation sequence for the two enzymes was observed. However, when capsules were employed as immobilization support, GOD efficiencies were higher than for the gel beads. These results were explained in terms of the structure of the capsules.

  10. A simple and accurate grading system for orthoiodohippurate renal scans in the assessment of post-transplant renal function

    SciTech Connect

    Zaki, S.K.; Bretan, P.N.; Go, R.T.; Rehm, P.K.; Streem, S.B.; Novick, A.C. )

    1990-06-01

    Orthoiodohippurate renal scanning has proved to be a reliable, noninvasive method for the evaluation and followup of renal allograft function. However, a standardized system for grading renal function with this test is not available. We propose a simple grading system to distinguish the different functional phases of hippurate scanning in renal transplant recipients. This grading system was studied in 138 patients who were evaluated 1 week after renal transplantation. There was a significant correlation between the isotope renographic functional grade and clinical correlates of allograft function such as the serum creatinine level (p = 0.0001), blood urea nitrogen level (p = 0.0001), urine output (p = 0.005) and need for hemodialysis (p = 0.007). We recommend this grading system as a simple and accurate method to interpret orthoiodohippurate renal scans in the evaluation and followup of renal allograft recipients.

  11. Accurate distortion estimation and optimal bandwidth allocation for scalable H.264 video transmission over MIMO systems.

    PubMed

    Jubran, Mohammad K; Bansal, Manu; Kondi, Lisimachos P; Grover, Rohan

    2009-01-01

    In this paper, we propose an optimal strategy for the transmission of scalable video over packet-based multiple-input multiple-output (MIMO) systems. The scalable extension of H.264/AVC that provides a combined temporal, quality and spatial scalability is used. For given channel conditions, we develop a method for the estimation of the distortion of the received video and propose different error concealment schemes. We show the accuracy of our distortion estimation algorithm in comparison with simulated wireless video transmission with packet errors. In the proposed MIMO system, we employ orthogonal space-time block codes (O-STBC) that guarantee independent transmission of different symbols within the block code. In the proposed constrained bandwidth allocation framework, we use the estimated end-to-end decoder distortion to optimally select the application layer parameters, i.e., quantization parameter (QP) and group of pictures (GOP) size, and physical layer parameters, i.e., rate-compatible turbo (RCPT) code rate and symbol constellation. Results show the substantial performance gain by using different symbol constellations across the scalable layers as compared to a fixed constellation.

  12. Wi-GIM system: a new wireless sensor network (WSN) for accurate ground instability monitoring

    NASA Astrophysics Data System (ADS)

    Mucchi, Lorenzo; Trippi, Federico; Schina, Rosa; Fornaciai, Alessandro; Gigli, Giovanni; Nannipieri, Luca; Favalli, Massimiliano; Marturia Alavedra, Jordi; Intrieri, Emanuele; Agostini, Andrea; Carnevale, Ennio; Bertolini, Giovanni; Pizziolo, Marco; Casagli, Nicola

    2016-04-01

    Landslides are among the most serious and common geologic hazards around the world. Their impact on human life is expected to increase in the next future as a consequence of human-induced climate change as well as the population growth in proximity of unstable slopes. Therefore, developing better performing technologies for monitoring landslides and providing local authorities with new instruments able to help them in the decision making process, is becoming more and more important. The recent progresses in Information and Communication Technologies (ICT) allow us to extend the use of wireless technologies in landslide monitoring. In particular, the developments in electronics components have permitted to lower the price of the sensors and, at the same time, to actuate more efficient wireless communications. In this work we present a new wireless sensor network (WSN) system, designed and developed for landslide monitoring in the framework of EU Wireless Sensor Network for Ground Instability Monitoring - Wi-GIM project (LIFE12 ENV/IT/001033). We show the preliminary performance of the Wi-GIM system after the first period of monitoring on the active Roncovetro Landslide and on a large subsiding area in the neighbourhood of Sallent village. The Roncovetro landslide is located in the province of Reggio Emilia (Italy) and moved an inferred volume of about 3 million cubic meters. Sallent village is located at the centre of the Catalan evaporitic basin in Spain. The Wi-GIM WSN monitoring system consists of three levels: 1) Master/Gateway level coordinates the WSN and performs data aggregation and local storage; 2) Master/Server level takes care of acquiring and storing data on a remote server; 3) Nodes level that is based on a mesh of peripheral nodes, each consisting in a sensor board equipped with sensors and wireless module. The nodes are located in the landslide ground perimeter and are able to create an ad-hoc WSN. The location of each sensor on the ground is

  13. Improved image quality in pinhole SPECT by accurate modeling of the point spread function in low magnification systems

    SciTech Connect

    Pino, Francisco; Roé, Nuria; Aguiar, Pablo; Falcon, Carles; Ros, Domènec; Pavía, Javier

    2015-02-15

    Purpose: Single photon emission computed tomography (SPECT) has become an important noninvasive imaging technique in small-animal research. Due to the high resolution required in small-animal SPECT systems, the spatially variant system response needs to be included in the reconstruction algorithm. Accurate modeling of the system response should result in a major improvement in the quality of reconstructed images. The aim of this study was to quantitatively assess the impact that an accurate modeling of spatially variant collimator/detector response has on image-quality parameters, using a low magnification SPECT system equipped with a pinhole collimator and a small gamma camera. Methods: Three methods were used to model the point spread function (PSF). For the first, only the geometrical pinhole aperture was included in the PSF. For the second, the septal penetration through the pinhole collimator was added. In the third method, the measured intrinsic detector response was incorporated. Tomographic spatial resolution was evaluated and contrast, recovery coefficients, contrast-to-noise ratio, and noise were quantified using a custom-built NEMA NU 4–2008 image-quality phantom. Results: A high correlation was found between the experimental data corresponding to intrinsic detector response and the fitted values obtained by means of an asymmetric Gaussian distribution. For all PSF models, resolution improved as the distance from the point source to the center of the field of view increased and when the acquisition radius diminished. An improvement of resolution was observed after a minimum of five iterations when the PSF modeling included more corrections. Contrast, recovery coefficients, and contrast-to-noise ratio were better for the same level of noise in the image when more accurate models were included. Ring-type artifacts were observed when the number of iterations exceeded 12. Conclusions: Accurate modeling of the PSF improves resolution, contrast, and recovery

  14. Evaluation of the EURO-CORDEX RCMs to accurately simulate the Etesian wind system

    NASA Astrophysics Data System (ADS)

    Dafka, Stella; Xoplaki, Elena; Toreti, Andrea; Zanis, Prodromos; Tyrlis, Evangelos; Luterbacher, Jürg

    2016-04-01

    The Etesians are among the most persistent regional scale wind systems in the lower troposphere that blow over the Aegean Sea during the extended summer season. ΑAn evaluation of the high spatial resolution, EURO-CORDEX Regional Climate Models (RCMs) is here presented. The study documents the performance of the individual models in representing the basic spatiotemporal pattern of the Etesian wind system for the period 1989-2004. The analysis is mainly focused on evaluating the abilities of the RCMs in simulating the surface wind over the Aegean Sea and the associated large scale atmospheric circulation. Mean Sea Level Pressure (SLP), wind speed and geopotential height at 500 hPa are used. The simulated results are validated against reanalysis datasets (20CR-v2c and ERA20-C) and daily observational measurements (12:00 UTC) from the mainland Greece and Aegean Sea. The analysis highlights the general ability of the RCMs to capture the basic features of the Etesians, but also indicates considerable deficiencies for selected metrics, regions and subperiods. Some of these deficiencies include the significant underestimation (overestimation) of the mean SLP in the northeastern part of the analysis domain in all subperiods (for May and June) when compared to 20CR-v2c (ERA20-C), the significant overestimation of the anomalous ridge over the Balkans and central Europe and the underestimation of the wind speed over the Aegean Sea. Future work will include an assessment of the Etesians for the next decades using EURO-CORDEX projections under different RCP scenarios and estimate the future potential for wind energy production.

  15. Recommendations for accurate heat capacity measurements using a Quantum Design physical property measurement system

    NASA Astrophysics Data System (ADS)

    Kennedy, Catherine A.; Stancescu, Maria; Marriott, Robert A.; White, Mary Anne

    2007-02-01

    A commercial instrument for determination of heat capacities of solids from ca. 400 K to 0.4 K, the physical property measurement system from Quantum Design, has been used to determine the heat capacities of a standard samples (sapphire [single crystal] and copper). We extend previous tests of the PPMS in three important ways: to temperatures as low as 0.4 K; to samples with poor thermal conductivity; to compare uncertainty with accuracy. We find that the accuracy of heat capacity determinations can be within 1% for 5 K < T < 300 K and 5% for 0.7 K < T < 5 K. Careful attention should be paid to the relative uncertainty for each data point, as determined from multiple measurements. While we have found that it is possible in some circumstances to obtain excellent results by measurement of samples that contribute more than ca. 1/3 to the total heat capacity, there is no "ideal" sample mass and sample geometry also is an important consideration. In fact, our studies of pressed pellets of zirconium tungstate, a poor thermal conductor, show that several samples of different masses should be determined for the highest degree of certainty.

  16. An Accurate Calibration Method Based on Velocity in a Rotational Inertial Navigation System.

    PubMed

    Zhang, Qian; Wang, Lei; Liu, Zengjun; Feng, Peide

    2015-01-01

    Rotation modulation is an effective method to enhance the accuracy of an inertial navigation system (INS) by modulating the gyroscope drifts and accelerometer bias errors into periodically varying components. The typical RINS drives the inertial measurement unit (IMU) rotation along the vertical axis and the horizontal sensors' errors are modulated, however, the azimuth angle error is closely related to vertical gyro drift, and the vertical gyro drift also should be modulated effectively. In this paper, a new rotation strategy in a dual-axis rotational INS (RINS) is proposed and the drifts of three gyros could be modulated, respectively. Experimental results from a real dual-axis RINS demonstrate that the maximum azimuth angle error is decreased from 0.04° to less than 0.01° during 1 h. Most importantly, the changing of rotation strategy leads to some additional errors in the velocity which is unacceptable in a high-precision INS. Then the paper studies the basic reason underlying horizontal velocity errors in detail and a relevant new calibration method is designed. Experimental results show that after calibration and compensation, the fluctuation and stages in the velocity curve disappear and velocity precision is improved. PMID:26225983

  17. Is TIRADS a practical and accurate system for use in daily clinical practice?

    PubMed Central

    Chandramohan, Anuradha; Khurana, Abhishek; Pushpa, B T; Manipadam, Marie Therese; Naik, Dukhabandhu; Thomas, Nihal; Abraham, Deepak; Paul, Mazhuvanchary Jacob

    2016-01-01

    Aim: To assess the positive predictive value (PPV) and inter-observer agreement of Thyroid Imaging Reporting and Data System (TIRADS) as described by Kwak et al. Materials and Methods: This was a prospective study wherein ultrasound was performed by two radiologists on patients with thyroid nodules >1 cm. The third radiologist interpreted archived images. Ultrasound features and TIRADS category were compared with cytology and surgical histopathology. PPV was calculated for all readers’ combined assessment. Inter-observer agreement was calculated using linear weighted kappa. Results: A total of 238 patients with 272 nodules of mean size 2.9 ± 1.7 cm were included. PPV for malignancy was 6.6%, 32%, 36%, 64%, 59%, and 91% for TIRADS 2, 3, 4a, 4b, 4c, and 5 categories, respectively. Inter-observer agreement was substantial [kappa (k) = 0.61-0.80] for assessment of nodule echogenicity, margins, calcification, and shape and good (k = 0.570, P < 0.001) for assessment of composition of the thyroid nodules. Overall agreement between observers was substantial for assigning TIRADS category [multi-rater weighted kappa coefficient (wt k) = 0.721, P < 0.001]. Conclusions: TIRADS is a simple and practical method of assessing thyroid nodules with high PPV and good inter-observer agreement. PMID:27081240

  18. An Accurate Calibration Method Based on Velocity in a Rotational Inertial Navigation System

    PubMed Central

    Zhang, Qian; Wang, Lei; Liu, Zengjun; Feng, Peide

    2015-01-01

    Rotation modulation is an effective method to enhance the accuracy of an inertial navigation system (INS) by modulating the gyroscope drifts and accelerometer bias errors into periodically varying components. The typical RINS drives the inertial measurement unit (IMU) rotation along the vertical axis and the horizontal sensors’ errors are modulated, however, the azimuth angle error is closely related to vertical gyro drift, and the vertical gyro drift also should be modulated effectively. In this paper, a new rotation strategy in a dual-axis rotational INS (RINS) is proposed and the drifts of three gyros could be modulated, respectively. Experimental results from a real dual-axis RINS demonstrate that the maximum azimuth angle error is decreased from 0.04° to less than 0.01° during 1 h. Most importantly, the changing of rotation strategy leads to some additional errors in the velocity which is unacceptable in a high-precision INS. Then the paper studies the basic reason underlying horizontal velocity errors in detail and a relevant new calibration method is designed. Experimental results show that after calibration and compensation, the fluctuation and stages in the velocity curve disappear and velocity precision is improved. PMID:26225983

  19. The decoupling of second-order linear systems with a singular mass matrix

    NASA Astrophysics Data System (ADS)

    Kawano, Daniel T.; Morzfeld, Matthias; Ma, Fai

    2013-12-01

    It was demonstrated in earlier work that a nondefective, linear dynamical system with an invertible mass matrix in free or forced motion may be decoupled in the configuration space by a real and isospectral transformation. We extend this work by developing a procedure for decoupling a linear dynamical system with a singular mass matrix in the configuration space, transforming the original differential-algebraic system into decoupled sets of real, independent, first- and second-order differential equations. Numerical examples are provided to illustrate the application of the decoupling procedure.

  20. Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria in Uganda.

    PubMed

    Yatsushiro, Shouki; Yamamoto, Takeki; Yamamura, Shohei; Abe, Kaori; Obana, Eriko; Nogami, Takahiro; Hayashi, Takuya; Sesei, Takashi; Oka, Hiroaki; Okello-Onen, Joseph; Odongo-Aginya, Emmanuel I; Alai, Mary Auma; Olia, Alex; Anywar, Dennis; Sakurai, Miki; Palacpac, Nirianne Mq; Mita, Toshihiro; Horii, Toshihiro; Baba, Yoshinobu; Kataoka, Masatoshi

    2016-01-01

    Accurate, sensitive, rapid, and easy operative diagnosis is necessary to prevent the spread of malaria. A cell microarray chip system including a push column for the recovery of erythrocytes and a fluorescence detector was employed for malaria diagnosis in Uganda. The chip with 20,944 microchambers (105 μm width and 50 μm depth) was made of polystyrene. For the analysis, 6 μl of whole blood was employed, and leukocytes were practically removed by filtration through SiO2-nano-fibers in a column. Regular formation of an erythrocyte monolayer in each microchamber was observed following dispersion of an erythrocyte suspension in a nuclear staining dye, SYTO 21, onto the chip surface and washing. About 500,000 erythrocytes were analyzed in a total of 4675 microchambers, and malaria parasite-infected erythrocytes could be detected in 5 min by using the fluorescence detector. The percentage of infected erythrocytes in each of 41 patients was determined. Accurate and quantitative detection of the parasites could be performed. A good correlation between examinations via optical microscopy and by our chip system was demonstrated over the parasitemia range of 0.0039-2.3438% by linear regression analysis (R(2) = 0.9945). Thus, we showed the potential of this chip system for the diagnosis of malaria. PMID:27445125

  1. Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria in Uganda

    PubMed Central

    Yatsushiro, Shouki; Yamamoto, Takeki; Yamamura, Shohei; Abe, Kaori; Obana, Eriko; Nogami, Takahiro; Hayashi, Takuya; Sesei, Takashi; Oka, Hiroaki; Okello-Onen, Joseph; Odongo-Aginya, Emmanuel I.; Alai, Mary Auma; Olia, Alex; Anywar, Dennis; Sakurai, Miki; Palacpac, Nirianne MQ; Mita, Toshihiro; Horii, Toshihiro; Baba, Yoshinobu; Kataoka, Masatoshi

    2016-01-01

    Accurate, sensitive, rapid, and easy operative diagnosis is necessary to prevent the spread of malaria. A cell microarray chip system including a push column for the recovery of erythrocytes and a fluorescence detector was employed for malaria diagnosis in Uganda. The chip with 20,944 microchambers (105 μm width and 50 μm depth) was made of polystyrene. For the analysis, 6 μl of whole blood was employed, and leukocytes were practically removed by filtration through SiO2-nano-fibers in a column. Regular formation of an erythrocyte monolayer in each microchamber was observed following dispersion of an erythrocyte suspension in a nuclear staining dye, SYTO 21, onto the chip surface and washing. About 500,000 erythrocytes were analyzed in a total of 4675 microchambers, and malaria parasite-infected erythrocytes could be detected in 5 min by using the fluorescence detector. The percentage of infected erythrocytes in each of 41 patients was determined. Accurate and quantitative detection of the parasites could be performed. A good correlation between examinations via optical microscopy and by our chip system was demonstrated over the parasitemia range of 0.0039–2.3438% by linear regression analysis (R2 = 0.9945). Thus, we showed the potential of this chip system for the diagnosis of malaria. PMID:27445125

  2. Evaluation of microwave digestion systems for mercury recovery in an oil matrix

    SciTech Connect

    Whitaker, M.J.; Clymire, J.W.

    1997-09-01

    The scope of this document is to characterize three microwave systems developed by CEM Corporation. The purpose of this investigative work was to evaluate the performance of each system for dissolution qualities and the recovery of mercury in an oil based matrix. The microwave systems evaluated were the heavy duty vessel system (HDV), the advanced composite system (ACV), and the open vessel system (OVS). All three systems have automated features, but all systems are limited by one factor or another. EPA method 3051 was the procedure used for sample preparation for this project. This particular microwave digestion method can also be used for other metal analytes of interest. Of the three different systems, only the HDV (now UDV) demonstrated complete digestion of the oil based matrix in a one step process and acceptable mercury recoveries.

  3. Standardization of vitrinite reflectance measurements in shale petroleum systems: How accurate are my Ro data?

    USGS Publications Warehouse

    Hackley, Paul C.

    2014-01-01

    Vitrinite reflectance generally is considered the most robust thermal maturity parameter available for application to hydrocarbon exploration and petroleum system evaluation. However, until 2011 there was no standardized methodology available to provide guidelines for vitrinite reflectance measurements in shale. Efforts to correct this deficiency resulted in publication of ASTM D7708-11: Standard test method for microscopical determination of the reflectance of vitrinite dispersed in sedimentary rocks. In 2012-2013, an interlaboratory exercise was conducted to establish precision limits for the measurement technique. Six samples, representing a wide variety of shale, were tested in duplicate by 28 analysts in 22 laboratories from 14 countries. Samples ranged from immature to overmature (Ro 0.31-1.53%), from organic-rich to organic-lean (1-22 wt.% total organic carbon), and contained Type I (lacustrine), Type II (marine), and Type III (terrestrial) kerogens. Repeatability values (difference between repetitive results from same operator, same conditions) ranged from 0.03-0.11% absolute reflectance, whereas reproducibility values (difference between results obtained on same test material by different operators, different laboratories) ranged from 0.12-0.54% absolute reflectance. Repeatability and reproducibility degraded consistently with increasing maturity and decreasing organic content. However, samples with terrestrial kerogens (Type III) fell off this trend, showing improved levels of reproducibility due to higher vitrinite content and improved ease of identification. Operators did not consistently meet the reporting requirements of the test method, indicating that a common reporting template is required to improve data quality. The most difficult problem encountered was the petrographic distinction of solid bitumens and low-reflecting inert macerals from vitrinite when vitrinite occurred with reflectance ranges overlapping the other components. Discussion among

  4. Physical activity intensity can be accurately monitored by smartphone global positioning system 'app'.

    PubMed

    Gordon, Brett Ashley; Bruce, Lyndell; Benson, Amanda Clare

    2016-08-01

    Monitoring physical activity is important to better individualise health and fitness benefits. This study assessed the concurrent validity of a smartphone global positioning system (GPS) 'app' and a sport-specific GPS device with a similar sampling rate, to measure physical activity components of speed and distance, compared to a higher sampling sport-specific GPS device. Thirty-eight (21 female, 17 male) participants, mean age of 24.68, s = 6.46 years, completed two 2.400 km trials around an all-weather athletics track wearing GPSports Pro™ (PRO), GPSports WiSpi™ (WISPI) and an iPhone™ with a Motion X GPS™ 'app' (MOTIONX). Statistical agreement, assessed using t-tests and Bland-Altman plots, indicated an (mean; 95% LOA) underestimation of 2% for average speed (0.126 km·h(-1); -0.389 to 0.642; p < .001), 1.7% for maximal speed (0.442 km·h(-1); -2.676 to 3.561; p = .018) and 1.9% for distance (0.045 km; -0.140 to 0.232; p < .001) by MOTIONX compared to that measured by PRO. In contrast, compared to PRO, WISPI overestimated average speed (0.232 km·h(-1); -0.376 to 0.088; p < .001) and distance (0.083 km; -0.129 to -0.038; p < .001) by 3.5% whilst underestimating maximal speed by 2.5% (0.474 km·h(-1); -1.152 to 2.099; p < .001). Despite the statistically significant difference, the MOTIONX measures intensity of physical activity, with a similar error as WISPI, to an acceptable level for population-based monitoring in unimpeded open-air environments. This presents a low-cost, minimal burden opportunity to remotely monitor physical activity participation to improve the prescription of exercise as medicine.

  5. Physical activity intensity can be accurately monitored by smartphone global positioning system 'app'.

    PubMed

    Gordon, Brett Ashley; Bruce, Lyndell; Benson, Amanda Clare

    2016-08-01

    Monitoring physical activity is important to better individualise health and fitness benefits. This study assessed the concurrent validity of a smartphone global positioning system (GPS) 'app' and a sport-specific GPS device with a similar sampling rate, to measure physical activity components of speed and distance, compared to a higher sampling sport-specific GPS device. Thirty-eight (21 female, 17 male) participants, mean age of 24.68, s = 6.46 years, completed two 2.400 km trials around an all-weather athletics track wearing GPSports Pro™ (PRO), GPSports WiSpi™ (WISPI) and an iPhone™ with a Motion X GPS™ 'app' (MOTIONX). Statistical agreement, assessed using t-tests and Bland-Altman plots, indicated an (mean; 95% LOA) underestimation of 2% for average speed (0.126 km·h(-1); -0.389 to 0.642; p < .001), 1.7% for maximal speed (0.442 km·h(-1); -2.676 to 3.561; p = .018) and 1.9% for distance (0.045 km; -0.140 to 0.232; p < .001) by MOTIONX compared to that measured by PRO. In contrast, compared to PRO, WISPI overestimated average speed (0.232 km·h(-1); -0.376 to 0.088; p < .001) and distance (0.083 km; -0.129 to -0.038; p < .001) by 3.5% whilst underestimating maximal speed by 2.5% (0.474 km·h(-1); -1.152 to 2.099; p < .001). Despite the statistically significant difference, the MOTIONX measures intensity of physical activity, with a similar error as WISPI, to an acceptable level for population-based monitoring in unimpeded open-air environments. This presents a low-cost, minimal burden opportunity to remotely monitor physical activity participation to improve the prescription of exercise as medicine. PMID:26505223

  6. Patient safety measures in burn care: do National reporting systems accurately reflect quality of burn care?

    PubMed

    Mandell, Samuel P; Robinson, Ellen F; Cooper, Claudette L; Klein, Matthew B; Gibran, Nicole S

    2010-01-01

    Recently, much attention has been placed on quality of care metrics and patient safety. Groups such as the University Health-System Consortium (UHC) collect and review patient safety data, monitor healthcare facilities, and often report data using mortality and complication rates as outcomes. The purpose of this study was to analyze the UHC database to determine if it differentiates quality of care across burn centers. We reviewed UHC clinical database (CDB) fields and available data from 2006 to 2008 for the burn product line. Based on the September 2008 American Burn Association (ABA) list of verified burn centers, we categorized centers as American Burn Association-verified burn centers, self-identified burn centers, and other centers that are not burn units but admit some burn patients. We compared total burn admissions, risk pool, complication rates, and mortality rates. Overall mortality was compared between the UHC and National Burn Repository. The UHC CDB provides fields for number of admissions, % intensive care unit admission, risk pool, length of stay, complication profiles, and mortality index. The overall numbers of burn patients in the database for the study period included 17,740 patients admitted to verified burn centers (mean 631 admissions/burn center/yr or per 2 years), 10,834 for self-identified burn centers (mean 437 admissions/burn center/yr or per 2 years), and 1,487 for other centers (mean 11.5 admissions/burn center/yr or per 2 years). Reported complication rates for verified burn centers (21.6%), self-identified burn centers (21.3%), and others (20%) were similar. Mortality rates were highest for self-identified burn centers (3.06%), less for verified centers (2.88%), and lowest for other centers (0.74%). However, these outcomes data may be misleading, because the risk pool criteria do not include burn-specific risk factors, and the inability to adjust for injury severity prevents rigorous comparison across centers. Databases such as the

  7. Computing the Moore-Penrose Inverse of a Matrix with a Computer Algebra System

    ERIC Educational Resources Information Center

    Schmidt, Karsten

    2008-01-01

    In this paper "Derive" functions are provided for the computation of the Moore-Penrose inverse of a matrix, as well as for solving systems of linear equations by means of the Moore-Penrose inverse. Making it possible to compute the Moore-Penrose inverse easily with one of the most commonly used Computer Algebra Systems--and to have the blueprint…

  8. Determination of first-order derivative matrix of wavefront aberration with respect to system variables.

    PubMed

    Lin, Psang Dain

    2012-02-01

    The first-order derivative matrix of a function with respect to a variable vector is referred to as the Jacobian matrix in mathematics. Current commercial software packages for the analysis and design of optical systems use a finite difference (FD) approximation methodology to estimate the Jacobian matrix of the wavefront aberration with respect to all of the independent system variables in a single raytracing pass such that the change of the wavefront aberration can be determined simply by computing the product of the developed Jacobian matrix and the corresponding changes in the system variables. The proposed method provides an ideal basis for automatic optical system design applications in which the merit function is defined in terms of wavefront aberration. The validity of the proposed approach is demonstrated by means of two illustrative examples. It is shown that the proposed method requires fewer iterations than the traditional FD approach and yields a more reliable and precise optimization performance. However, the proposed method incurs an additional CPU overhead in computing the Jacobian matrix of the merit function. As a result, the CPU time required to complete the optimization process is longer than that required by the FD method. PMID:22307119

  9. Symmetry of matrix-valued stochastic processes and noncolliding diffusion particle systems

    NASA Astrophysics Data System (ADS)

    Katori, Makoto; Tanemura, Hideki

    2004-08-01

    As an extension of the theory of Dyson's Brownian motion models for the standard Gaussian random-matrix ensembles, we report a systematic study of Hermitian matrix-valued processes and their eigenvalue processes associated with the chiral and nonstandard random-matrix ensembles. In addition to the noncolliding Brownian motions, we introduce a one-parameter family of temporally homogeneous noncolliding systems of the Bessel processes and a two-parameter family of temporally inhomogeneous noncolliding systems of Yor's generalized meanders and show that all of the ten classes of eigenvalue statistics in the Altland-Zirnbauer classification are realized as particle distributions in the special cases of these diffusion particle systems. As a corollary of each equivalence in distribution of a temporally inhomogeneous eigenvalue process and a noncolliding diffusion process, a stochastic-calculus proof of a version of the Harish-Chandra (Itzykson-Zuber) formula of integral over unitary group is established.

  10. SU-E-T-475: An Accurate Linear Model of Tomotherapy MLC-Detector System for Patient Specific Delivery QA

    SciTech Connect

    Chen, Y; Mo, X; Chen, M; Olivera, G; Parnell, D; Key, S; Lu, W; Reeher, M; Galmarini, D

    2014-06-01

    Purpose: An accurate leaf fluence model can be used in applications such as patient specific delivery QA and in-vivo dosimetry for TomoTherapy systems. It is known that the total fluence is not a linear combination of individual leaf fluence due to leakage-transmission, tongue-and-groove, and source occlusion effect. Here we propose a method to model the nonlinear effects as linear terms thus making the MLC-detector system a linear system. Methods: A leaf pattern basis (LPB) consisting of no-leaf-open, single-leaf-open, double-leaf-open and triple-leaf-open patterns are chosen to represent linear and major nonlinear effects of leaf fluence as a linear system. An arbitrary leaf pattern can be expressed as (or decomposed to) a linear combination of the LPB either pulse by pulse or weighted by dwelling time. The exit detector responses to the LPB are obtained by processing returned detector signals resulting from the predefined leaf patterns for each jaw setting. Through forward transformation, detector signal can be predicted given a delivery plan. An equivalent leaf open time (LOT) sinogram containing output variation information can also be inversely calculated from the measured detector signals. Twelve patient plans were delivered in air. The equivalent LOT sinograms were compared with their planned sinograms. Results: The whole calibration process was done in 20 minutes. For two randomly generated leaf patterns, 98.5% of the active channels showed differences within 0.5% of the local maximum between the predicted and measured signals. Averaged over the twelve plans, 90% of LOT errors were within +/−10 ms. The LOT systematic error increases and shows an oscillating pattern when LOT is shorter than 50 ms. Conclusion: The LPB method models the MLC-detector response accurately, which improves patient specific delivery QA and in-vivo dosimetry for TomoTherapy systems. It is sensitive enough to detect systematic LOT errors as small as 10 ms.

  11. A frozen matrix hybrid optical nonlinear system enhanced by a particle lens

    NASA Astrophysics Data System (ADS)

    Chen, Lianwei; Zheng, Xiaorui; Du, Zheren; Jia, Baohua; Gu, Min; Hong, Minghui

    2015-09-01

    In this work, a Graphene Oxide (GO) nano-sheet and SiO2 micro-bead hybrid system based on a frozen matrix was investigated for its enhanced optical nonlinear performance. A frozen matrix is a novel approach that hosts the optical nonlinear nano-particles, which combines the strengths from both liquid and solid phase systems for high performance photonic applications. SiO2 micro-beads were used to induce a local field enhancement effect that improved the optical nonlinearity of GO nano-sheets. The nonlinear performance of the hybrid system is several orders higher than the existing GO nano-sheet liquid dispersion. In addition, this frozen matrix and the local field enhancement effect are two facile and versatile methods that can be applied to many types of nano-particle dispersions.In this work, a Graphene Oxide (GO) nano-sheet and SiO2 micro-bead hybrid system based on a frozen matrix was investigated for its enhanced optical nonlinear performance. A frozen matrix is a novel approach that hosts the optical nonlinear nano-particles, which combines the strengths from both liquid and solid phase systems for high performance photonic applications. SiO2 micro-beads were used to induce a local field enhancement effect that improved the optical nonlinearity of GO nano-sheets. The nonlinear performance of the hybrid system is several orders higher than the existing GO nano-sheet liquid dispersion. In addition, this frozen matrix and the local field enhancement effect are two facile and versatile methods that can be applied to many types of nano-particle dispersions. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr03304g

  12. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    SciTech Connect

    Cotte, F.P.; Doughty, C.; Birkholzer, J.

    2010-11-01

    The ability to reliably predict flow and transport in fractured porous rock is an essential condition for performance evaluation of geologic (underground) nuclear waste repositories. In this report, a suite of programs (TRIPOLY code) for calculating and analyzing flow and transport in two-dimensional fracture-matrix systems is used to model single-well injection-withdrawal (SWIW) tracer tests. The SWIW test, a tracer test using one well, is proposed as a useful means of collecting data for site characterization, as well as estimating parameters relevant to tracer diffusion and sorption. After some specific code adaptations, we numerically generated a complex fracture-matrix system for computation of steady-state flow and tracer advection and dispersion in the fracture network, along with solute exchange processes between the fractures and the porous matrix. We then conducted simulations for a hypothetical but workable SWIW test design and completed parameter sensitivity studies on three physical parameters of the rock matrix - namely porosity, diffusion coefficient, and retardation coefficient - in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, is also modeled in this study, in two different ways: (1) by increasing the hydraulic aperture for flow in existing fractures and (2) by adding a new set of fractures to the field. The results of all these different tests are analyzed by studying the population of matrix blocks, the tracer spatial distribution, and the breakthrough curves (BTCs) obtained, while performing mass-balance checks and being careful to avoid some numerical mistakes that could occur. This study clearly demonstrates the importance of matrix effects in the solute transport process, with the sensitivity studies illustrating the increased importance of the matrix in providing a retardation mechanism for radionuclides as matrix porosity, diffusion coefficient, or retardation

  13. Numerical modelling of transdermal delivery from matrix systems: parametric study and experimental validation with silicone matrices.

    PubMed

    Snorradóttir, Bergthóra S; Jónsdóttir, Fjóla; Sigurdsson, Sven Th; Másson, Már

    2014-08-01

    A model is presented for transdermal drug delivery from single-layered silicone matrix systems. The work is based on our previous results that, in particular, extend the well-known Higuchi model. Recently, we have introduced a numerical transient model describing matrix systems where the drug dissolution can be non-instantaneous. Furthermore, our model can describe complex interactions within a multi-layered matrix and the matrix to skin boundary. The power of the modelling approach presented here is further illustrated by allowing the possibility of a donor solution. The model is validated by a comparison with experimental data, as well as validating the parameter values against each other, using various configurations with donor solution, silicone matrix and skin. Our results show that the model is a good approximation to real multi-layered delivery systems. The model offers the ability of comparing drug release for ibuprofen and diclofenac, which cannot be analysed by the Higuchi model because the dissolution in the latter case turns out to be limited. The experiments and numerical model outlined in this study could also be adjusted to more general formulations, which enhances the utility of the numerical model as a design tool for the development of drug-loaded matrices for trans-membrane and transdermal delivery.

  14. Assessment of a three-dimensional line-of-response probability density function system matrix for PET.

    PubMed

    Yao, Rutao; Ramachandra, Ranjith M; Mahajan, Neeraj; Rathod, Vinay; Gunasekar, Noel; Panse, Ashish; Ma, Tianyu; Jian, Yiqiang; Yan, Jianhua; Carson, Richard E

    2012-11-01

    To achieve optimal PET image reconstruction through better system modeling, we developed a system matrix that is based on the probability density function for each line of response (LOR-PDF). The LOR-PDFs are grouped by LOR-to-detector incident angles to form a highly compact system matrix. The system matrix was implemented in the MOLAR list mode reconstruction algorithm for a small animal PET scanner. The impact of LOR-PDF on reconstructed image quality was assessed qualitatively as well as quantitatively in terms of contrast recovery coefficient (CRC) and coefficient of variance (COV), and its performance was compared with a fixed Gaussian (iso-Gaussian) line spread function. The LOR-PDFs of three coincidence signal emitting sources, (1) ideal positron emitter that emits perfect back-to-back γ rays (γγ) in air; (2) fluorine-18 (¹⁸F) nuclide in water; and (3) oxygen-15 (¹⁵O) nuclide in water, were derived, and assessed with simulated and experimental phantom data. The derived LOR-PDFs showed anisotropic and asymmetric characteristics dependent on LOR-detector angle, coincidence emitting source, and the medium, consistent with common PET physical principles. The comparison of the iso-Gaussian function and LOR-PDF showed that: (1) without positron range and acollinearity effects, the LOR-PDF achieved better or similar trade-offs of contrast recovery and noise for objects of 4 mm radius or larger, and this advantage extended to smaller objects (e.g. 2 mm radius sphere, 0.6 mm radius hot-rods) at higher iteration numbers; and (2) with positron range and acollinearity effects, the iso-Gaussian achieved similar or better resolution recovery depending on the significance of positron range effect. We conclude that the 3D LOR-PDF approach is an effective method to generate an accurate and compact system matrix. However, when used directly in expectation-maximization based list-mode iterative reconstruction algorithms such as MOLAR, its superiority is not clear

  15. Modelling the nanomechanical response of a micro particle–matrix system for nanoindentation tests

    NASA Astrophysics Data System (ADS)

    Cao, Yunyi; Duan, Pengfei; Chen, Jinju

    2016-05-01

    A lot of experimental, numerical simulation and analytical modelling work has been done on how the substrate affects the measured hardness and elastic modulus of the coating/substrate system for nanoindentation tests. Little work has been done on the elastic–plastic behaviour of micro particle–matrix systems. Clifford et al have proposed an empirical model to describe the spatially dependent composite modulus during nanoindentation tests for linear elastic particles embedded in a linear elastic matrix. However, no such models have been developed for elastic–plastic composites. In this study, finite element simulations were used to determine the elastic modulus and hardness of hard particles embedded in a soft matrix and vice versa. An extended Clifford model has been developed to determine the elastic modulus and hardness for elastic–plastic composites with various particle shapes and volume fractions.

  16. Non-stochastic matrix Schrödinger equation for open systems

    NASA Astrophysics Data System (ADS)

    Joubert-Doriol, Loïc; Ryabinkin, Ilya G.; Izmaylov, Artur F.

    2014-12-01

    We propose an extension of the Schrödinger equation for a quantum system interacting with environment. This extension describes dynamics of a collection of auxiliary wavefunctions organized as a matrix m, from which the system density matrix can be reconstructed as hat{ρ }= {m} {m}^dagger. We formulate a compatibility condition, which ensures that the reconstructed density satisfies a given quantum master equation for the system density. The resulting non-stochastic evolution equation preserves positive-definiteness of the system density and is applicable to both Markovian and non-Markovian system-bath treatments. Our formalism also resolves a long-standing problem of energy loss in the time-dependent variational principle applied to mixed states of closed systems.

  17. Non-stochastic matrix Schrödinger equation for open systems

    SciTech Connect

    Joubert-Doriol, Loïc; Ryabinkin, Ilya G.; Izmaylov, Artur F.

    2014-12-21

    We propose an extension of the Schrödinger equation for a quantum system interacting with environment. This extension describes dynamics of a collection of auxiliary wavefunctions organized as a matrix m, from which the system density matrix can be reconstructed as ρ{sup ^}=mm{sup †}. We formulate a compatibility condition, which ensures that the reconstructed density satisfies a given quantum master equation for the system density. The resulting non-stochastic evolution equation preserves positive-definiteness of the system density and is applicable to both Markovian and non-Markovian system-bath treatments. Our formalism also resolves a long-standing problem of energy loss in the time-dependent variational principle applied to mixed states of closed systems.

  18. Accurate treatments of electrostatics for computer simulations of biological systems: A brief survey of developments and existing problems

    NASA Astrophysics Data System (ADS)

    Yi, Sha-Sha; Pan, Cong; Hu, Zhong-Han

    2015-12-01

    Modern computer simulations of biological systems often involve an explicit treatment of the complex interactions among a large number of molecules. While it is straightforward to compute the short-ranged Van der Waals interaction in classical molecular dynamics simulations, it has been a long-lasting issue to develop accurate methods for the longranged Coulomb interaction. In this short review, we discuss three types of methodologies for the accurate treatment of electrostatics in simulations of explicit molecules: truncation-type methods, Ewald-type methods, and mean-field-type methods. Throughout the discussion, we brief the formulations and developments of these methods, emphasize the intrinsic connections among the three types of methods, and focus on the existing problems which are often associated with the boundary conditions of electrostatics. This brief survey is summarized with a short perspective on future trends along the method developments and applications in the field of biological simulations. Project supported by the National Natural Science Foundation of China (Grant Nos. 91127015 and 21522304) and the Open Project from the State Key Laboratory of Theoretical Physics, and the Innovation Project from the State Key Laboratory of Supramolecular Structure and Materials.

  19. Dynamics of the matrix in DMS Type-II quantum dot systems

    NASA Astrophysics Data System (ADS)

    Brown, Collin R.; Whiteside, Vince R.; Sellers, Ian R.; Petrou, Athos; Chou, W.-C.

    Magnetic field, temperature, and polarization dependent continuous wave photoluminescence spectroscopy (PL) is used to study two related Type-II quantum dots (QDs). These techniques were used to study how the location of magnetic impurities affects the formation of magnetic polarons in these two (related) systems. The ZnMnTe/ZnSe system has Mn impurities located within the QDs, with (ideally) no Mn in the surrounding ZnSe matrix. The ZnTe/ZnMnSe QDs have Mn impurities grown within the matrix, which ideally is excluded from the QDs. For both these systems, the holes are confined within the dots, while the electrons are located in the surrounding matrix. The location of the Mn and its coupling with the spin of the corresponding carrier leads to distinct characteristics for each system. Due to difficulties growing these systems, some diffusion of Mn during the growth of these samples is suspected, leading to a percentage of magnetic impurities unintentionally located in the non-magnetic region for both samples. The emission from the matrix in particular was studied to determine the effect/composition of Mn in this region and its contribution to the characteristics of the QDs. This work is supported by NSF DMR-1305770.

  20. A similarity solution for reaction front propagation in a fracture-matrix system.

    PubMed

    Rajaram, Harihar; Arshadi, Masoud

    2016-10-13

    We propose a new composite similarity variable, based on which a similarity solution is derived for reaction front propagation in fracture-matrix systems. The similarity solution neglects diffusion/dispersion within the fracture and assumes the existence of a sharp reaction front in the rock matrix. The reaction front location in the rock matrix is shown to follow a linear decrease with distance along the fracture. The reaction front propagation along the fracture is shown to scale like diffusion (i.e. as the square root of time). The similarity solution using the composite similarity variable appears to be applicable to a broad class of reactive transport problems involving mineral reactions in fracture-matrix systems. It also reproduces the solutions for non-reactive solute and heat transport when diffusion/dispersion/conduction are neglected in the fracture. We compared our similarity solution against numerical simulations for nonlinear reactive transport of an aqueous species with a mineral in the rock matrix. The similarity solutions agree very well with the numerical solutions, especially at later times when diffusion limitations are more pronounced.This article is part of the themed issue 'Energy and the subsurface'. PMID:27597793

  1. Chitosan-polycarbophil interpolyelectrolyte complex as an excipient for bioadhesive matrix systems to control macromolecular drug delivery.

    PubMed

    Lu, Zhilei; Chen, Weiyang; Hamman, Josias H; Ni, Jian; Zhai, Xiaoling

    2008-01-01

    The in vitro performance of monolithic matrix systems containing the interpolyelectrolyte complex between chitosan and polycarbophil as excipient was evaluated in terms of their swelling, bioadhesive, and drug release properties. The different matrix systems showed excellent swelling properties without erosion, except for the formulation containing the highest quantity chitosan-polycarbophil complex that exhibited surface erosion in addition to swelling. All the different matrix systems exhibited significantly higher bioadhesive properties than the control group. Furthermore, they showed controlled insulin release without an initial burst release effect. However, only the matrix system that exhibited surface erosion in combination with swelling approached zero-order release.

  2. Accurate and agile digital control of optical phase, amplitude and frequency for coherent atomic manipulation of atomic systems.

    PubMed

    Thom, Joseph; Wilpers, Guido; Riis, Erling; Sinclair, Alastair G

    2013-08-12

    We demonstrate a system for fast and agile digital control of laser phase, amplitude and frequency for applications in coherent atomic systems. The full versatility of a direct digital synthesis radiofrequency source is faithfully transferred to laser radiation via acousto-optic modulation. Optical beatnotes are used to measure phase steps up to 2π, which are accurately implemented with a resolution of ≤ 10 mrad. By linearizing the optical modulation process, amplitude-shaped pulses of durations ranging from 500 ns to 500 ms, in excellent agreement with the programmed functional form, are demonstrated. Pulse durations are limited only by the 30 ns rise time of the modulation process, and a measured extinction ratio of > 5 × 10(11) is achieved. The system presented here was developed specifically for controlling the quantum state of trapped ions with sequences of multiple laser pulses, including composite and bichromatic pulses. The demonstrated techniques are widely applicable to other atomic systems ranging across quantum information processing, frequency metrology, atom interferometry, and single-photon generation.

  3. Vitamins E and C - effects on matrix components in the vascular system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The connective tissue in the vascular system, consisting mainly of vascular smooth muscle cells (VSMC) and the interstitial extracellular matrix (ECM), plays important roles in the maintenance of an intact vascular wall as well as in the repair of atherosclerotic lesions during disease development. ...

  4. The implications of episodic nonequilibrium fracture-matrix flow on site suitability and total system performance

    SciTech Connect

    Nitao, J.J.; Buscheck, T.A.; Chesnut, D.A.

    1992-04-01

    We apply our work on fracture- and matrix-dominated flow to develop a conceptual model of hydrological flow processes in the unsaturated zone at Yucca Mountain. The possibility of fracture-dominated flow is discussed, and various deductions are made on its impact on natural and total system performance, site characterization activities, and site suitability determination.

  5. Chitosan-polycarbophil complexes in swellable matrix systems for controlled drug release.

    PubMed

    Lu, Z; Chen, W; Hamman, J H

    2007-10-01

    A prerequisite for progress in the design of novel drug delivery systems is the development of excipients that are capable of fulfilling multifunctional roles such as controlling the release of the drug according to the therapeutic needs. Although several polymers have been utilised in the development of specialised drug delivery systems, their scope in dosage form design can be enlarged through combining different polymers. When a polymer is cross-linked or complexed with an oppositely charged polyelectrolyte, a three-dimensional network is formed in which the drug can be incorporated to control its release. The swelling properties and release kinetics of two model drugs with different water solubilities (i.e. diltiazem and ibuprofen) from monolithic matrix tablets consisting of an interpolyelectrolyte complex between chitosan and polycarbophil are reported. Matrix tablets consisting of this polymeric complex without drug or excipients exhibited extremely high swelling properties that are completely reversible upon drying. The drug release from matrix systems with different formulations depended on the concentration of the chitosan-polycarbophil interpolyelectrolyte complex and approached zero order release kinetics for both model drugs. The chitosan-polycarbophil interpolyelectrolyte complex has demonstrated a high potential as an excipient for the production of swellable matrix systems with controlled drug release properties.

  6. Development of an extracellular matrix delivery system for effective intramyocardial injection in ischemic tissue.

    PubMed

    Slaughter, Mark S; Soucy, Kevin G; Matheny, Robert G; Lewis, Beecher C; Hennick, Michael F; Choi, Young; Monreal, Gretel; Sobieski, Michael A; Giridharan, Guruprasad A; Koenig, Steven C

    2014-01-01

    Biomaterials with direct intramyocardial injection devices have been developed and are being investigated as a potential cardiac regenerative therapy for end-stage ischemic heart failure. Decellularized extracellular matrix (ECM) has been shown to improve cardiac function and attenuate or reverse pathologic remodeling cascades. CorMatrix Cardiovascular, Inc. has developed a porcine small intestinal submucosa-derived particulate extracellular matrix (P-ECM) and ECM Delivery System to provide uniform and controlled intramyocardial delivery of the injectable P-ECM material into infarcted regions. The CorMatrix ECM Delivery System is composed of a Multi-Needle P-ECM Syringe Assembly, Automated Injection Controller, and Tissue Depth Measurement System (portable ultrasound). Feasibility of the P-ECM delivery system was tested intraoperatively in a chronic ischemic heart failure bovine model (n = 11), and demonstrated the ability to control injection volume (0.1-1.0 ml) and depth of penetration (3-5 mm) under regulated injection pressure (150 psi CO2) into the ischemic region. Targeted intramyocardial delivery of P-ECM may improve efficacy and enable development of novel patient-specific therapy. PMID:25232775

  7. Linear System of Equations, Matrix Inversion, and Linear Programming Using MS Excel

    ERIC Educational Resources Information Center

    El-Gebeily, M.; Yushau, B.

    2008-01-01

    In this note, we demonstrate with illustrations two different ways that MS Excel can be used to solve Linear Systems of Equation, Linear Programming Problems, and Matrix Inversion Problems. The advantage of using MS Excel is its availability and transparency (the user is responsible for most of the details of how a problem is solved). Further, we…

  8. Analysis of a photoacoustic imaging system by the crosstalk matrix and singular value decomposition

    PubMed Central

    Roumeliotis, Michael; Stodilka, Robert Z.; Anastasio, Mark A.; Chaudhary, Govind; Al-Aabed, Hazem; Ng, Eldon; Immucci, Andrea; Carson, Jeffrey J.L.

    2010-01-01

    Photoacoustic imaging is a hybrid imaging modality capable of producing contrast similar to optical imaging techniques but with increased penetration depth and resolution in turbid media by encoding the information as acoustic waves. In general, it is important to characterize the performance of a photoacoustic imaging system by parameters such as sensitivity, resolution, and contrast. However, system characterization can extend beyond these metrics by implementing advanced analysis via the crosstalk matrix and singular value decomposition. A method was developed to experimentally measure a matrix that represented the imaging operator for a photoacoustic imaging system. Computations to produce the crosstalk matrix were completed to provide insight into the spatially dependent sensitivity and aliasing for the photoacoustic imaging system. Further analysis of the imaging operator was done via singular value decomposition to estimate the capability of the imaging system to reconstruct objects and the inherent sensitivity to those objects. The results provided by singular value decomposition were compared to SVD results from a de-noised imaging operator to estimate the number of measurable singular vectors for the system. These characterization techniques can be broadly applied to any photoacoustic system and, with regards to the studied system, could be used as a basis for improvements to future iterations. PMID:20589001

  9. Phase space localization and matrix element distributions in systems with mixed classical phase space.

    PubMed

    Mehlig, B; Müller, K; Eckhardt, B

    1999-05-01

    We consider distributions of diagonal matrix elements for smooth observables in systems whose classical phase space has a mixture of chaotic and nearly integrable regions. The quantum distributions agree very well with distributions obtained from classical trajectory segments whose length is the Heisenberg time. Non-Gaussian wings in the distributions can be linked to classical trapping in certain parts of phase space, sometimes connected to islands, but also to regions separated by other barriers to transport. Thus classical deviations from ergodicity are quantitatively reflected in quantum matrix elements. The relation to scars is discussed.

  10. Investigation of fracture-matrix interaction: Preliminary experiments in a simple system

    SciTech Connect

    Foltz, S.D.; Tidwell, V.C.; Glass, R.J.; Sobolik, S.R.

    1992-12-31

    Paramount to the modeling of unsaturated flow and transport through fractured porous media is a clear understanding of the processes controlling fracture-matrix interaction. As a first step toward such an understanding, two preliminary experiments have been performed to investigate the influence of matrix imbibition on water percolation through unsaturated fractures in the plane normal to the fracture. Test systems consisted of thin slabs of either tuff or an analog material cut by a single vertical fracture into which a constant fluid flux was introduced. Transient moisture content and solute concentration fields were imaged by means of x-ray absorption. Flow fields associated with the two different media were significantly different owing to differences in material properties relative to the imposed flux. Richards` equation was found to be a valid means of modeling the imbibition of water into the tuff matrix from a saturated fracture for the current experiment.

  11. Extraction and Analysis of Inter-area Oscillation Using Improved Multi-signal Matrix Pencil Algorithm Based on Data Reduction in Power System

    NASA Astrophysics Data System (ADS)

    Liu, Cheng; Cai, Guowei; Yang, Deyou; Sun, Zhenglong

    2016-08-01

    In this paper, a robust online approach based on wavelet transform and matrix pencil (WTMP) is proposed to extract the dominant oscillation mode and parameters (frequency, damping, and mode shape) of a power system from wide-area measurements. For accurate and robust extraction of parameters, WTMP is verified as an effective identification algorithm for output-only modal analysis. First, singular value decomposition (SVD) is used to reduce the covariance signals obtained by natural excitation technique. Second, the orders and range of the corresponding frequency are determined by SVD from positive power spectrum matrix. Finally, the modal parameters are extracted from each mode of reduced signals using the matrix pencil algorithm in different frequency ranges. Compared with the original algorithm, the advantage of the proposed method is that it reduces computation data size and can extract mode shape. The effectiveness of the scheme, which is used for accurate extraction of the dominant oscillation mode and its parameters, is thoroughly studied and verified using the response signal data generated from 4-generator 2-area and 16-generator 5-area test systems.

  12. The Type II secretion system delivers matrix proteins for biofilm formation by Vibrio cholerae.

    PubMed

    Johnson, Tanya L; Fong, Jiunn C; Rule, Chelsea; Rogers, Andrew; Yildiz, Fitnat H; Sandkvist, Maria

    2014-12-01

    Gram-negative bacteria have evolved several highly dedicated pathways for extracellular protein secretion, including the type II secretion (T2S) system. Since substrates secreted via the T2S system include both virulence factors and degradative enzymes, this secretion system is considered a major survival mechanism for pathogenic and environmental species. Previous analyses revealed that the T2S system mediates the export of ≥ 20 proteins in Vibrio cholerae, a human pathogen that is indigenous to the marine environment. Here we demonstrate a new role in biofilm formation for the V. cholerae T2S system, since wild-type V. cholerae was found to secrete the biofilm matrix proteins RbmC, RbmA, and Bap1 into the culture supernatant, while an isogenic T2S mutant could not. In agreement with this finding, the level of biofilm formation in a static microtiter assay was diminished in T2S mutants. Moreover, inactivation of the T2S system in a rugose V. cholerae strain prevented the development of colony corrugation and pellicle formation at the air-liquid interface. In contrast, extracellular secretion of the exopolysaccharide VPS, an essential component of the biofilm matrix, remained unaffected in the T2S mutants. Our results indicate that the T2S system provides a mechanism for the delivery of extracellular matrix proteins known to be important for biofilm formation by V. cholerae. Because the T2S system contributes to the pathogenicity of V. cholerae by secreting proteins such as cholera toxin and biofilm matrix proteins, elucidation of the molecular mechanism of T2S has the potential to lead to the development of novel preventions and therapies. PMID:25266381

  13. SU-E-J-134: An Augmented-Reality Optical Imaging System for Accurate Breast Positioning During Radiotherapy

    SciTech Connect

    Nazareth, D; Malhotra, H; French, S; Hoffmann, K; Merrow, C

    2014-06-01

    Purpose: Breast radiotherapy, particularly electronic compensation, may involve large dose gradients and difficult patient positioning problems. We have developed a simple self-calibrating augmented-reality system, which assists in accurately and reproducibly positioning the patient, by displaying her live image from a single camera superimposed on the correct perspective projection of her 3D CT data. Our method requires only a standard digital camera capable of live-view mode, installed in the treatment suite at an approximately-known orientation and position (rotation R; translation T). Methods: A 10-sphere calibration jig was constructed and CT imaged to provide a 3D model. The (R,T) relating the camera to the CT coordinate system were determined by acquiring a photograph of the jig and optimizing an objective function, which compares the true image points to points calculated with a given candidate R and T geometry. Using this geometric information, 3D CT patient data, viewed from the camera's perspective, is plotted using a Matlab routine. This image data is superimposed onto the real-time patient image, acquired by the camera, and displayed using standard live-view software. This enables the therapists to view both the patient's current and desired positions, and guide the patient into assuming the correct position. The method was evaluated using an in-house developed bolus-like breast phantom, mounted on a supporting platform, which could be tilted at various angles to simulate treatment-like geometries. Results: Our system allowed breast phantom alignment, with an accuracy of about 0.5 cm and 1 ± 0.5 degree. Better resolution could be possible using a camera with higher-zoom capabilities. Conclusion: We have developed an augmented-reality system, which combines a perspective projection of a CT image with a patient's real-time optical image. This system has the potential to improve patient setup accuracy during breast radiotherapy, and could possibly be

  14. A bronchoscopic navigation system using bronchoscope center calibration for accurate registration of electromagnetic tracker and CT volume without markers

    SciTech Connect

    Luo, Xiongbiao

    2014-06-15

    electromagnetically navigated bronchoscopy system was constructed with accurate registration of an electromagnetic tracker and the CT volume on the basis of an improved marker-free registration approach that uses the bronchial centerlines and bronchoscope tip center information. The fiducial and target registration errors of our electromagnetic navigation system were about 6.6 and 4.5 mm in dynamic bronchial phantom validation.

  15. Theory of open quantum systems with bath of electrons and phonons and spins: Many-dissipaton density matrixes approach

    SciTech Connect

    Yan, YiJing

    2014-02-07

    This work establishes a strongly correlated system-and-bath dynamics theory, the many-dissipaton density operators formalism. It puts forward a quasi-particle picture for environmental influences. This picture unifies the physical descriptions and algebraic treatments on three distinct classes of quantum environments, electron bath, phonon bath, and two-level spin or exciton bath, as their participating in quantum dissipation processes. Dynamical variables for theoretical description are no longer just the reduced density matrix for system, but remarkably also those for quasi-particles of bath. The present theoretical formalism offers efficient and accurate means for the study of steady-state (nonequilibrium and equilibrium) and real-time dynamical properties of both systems and hybridizing environments. It further provides universal evaluations, exact in principle, on various correlation functions, including even those of environmental degrees of freedom in coupling with systems. Induced environmental dynamics could be reflected directly in experimentally measurable quantities, such as Fano resonances and quantum transport current shot noise statistics.

  16. Parameter identification of fractional order linear system based on Haar wavelet operational matrix.

    PubMed

    Li, Yuanlu; Meng, Xiao; Zheng, Bochao; Ding, Yaqing

    2015-11-01

    Fractional order systems can be more adequate for the description of dynamical systems than integer order models, however, how to obtain fractional order models are still actively exploring. In this paper, an identification method for fractional order linear system was proposed. This is a method based on input-output data in time domain. The input and output signals are represented by Haar wavelet, and then fractional order systems described by fractional order differential equations are transformed into fractional order integral equations. Taking use of the Haar wavelet operational matrix of the fractional order integration, the fractional order linear system can easily be converted into a system of algebraic equation. Finally, the parameters of the fractional order system are determined by minimizing the errors between the output of the real system and that of the identified system. Numerical simulations, involving integral and fractional order systems, confirm the efficiency of the above methodology.

  17. Comparison of the accuracy of matrix-assisted laser desorption ionization-time of flight mass spectrometry with that of other commercial identification systems for identifying Staphylococcus saprophyticus in urine.

    PubMed

    Lee, Tai-Fen; Lee, Hao; Chen, Chung-Ming; Du, Shin-Hei; Cheng, Ya-Chih; Hsu, Chen-Ching; Chung, Meng-Yu; Teng, Shih-Hua; Teng, Lee-Jene; Hsueh, Po-Ren

    2013-05-01

    Among 30 urinary isolates of Staphylococcus saprophyticus identified by sequencing methods, the rate of accurate identification was 100% for Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), 86.7% for the Phoenix PID and Vitek 2 GP systems, 93.3% for the MicroScan GP33 system, and 46.7% for the BBL CHROMagar Orientation system.

  18. Matrix effects of TRU (transuranic) assays using the SWEPP PAN assay system

    SciTech Connect

    Smith, J.R.

    1990-08-01

    The Drum Assay System (DAS) at the Stored Waste Experimental Pilot Plant (SWEPP) is a second-generation active-passive neutron assay system. It has been used to assay over 5000 208-liter drums of transuranic waste from the Rocky Flats Plant (RFP). Data from these assays have been examined and compared with the assays performed at Rocky Flats, mainly utilize counting of {sup 239}Pu gamma rays. For the most part the passive assays are in very good agreement with the Rocky Flats assays. The active assays are strongly correlated with the results of the other two methods, but require matrix-dependent correction factors beyond those provided by the system itself. A set of matrix-dependent correction factors has been developed from the study of the assay results. 3 refs., 4 figs., 3 tabs.

  19. RBAC-Matrix-based EMR right management system to improve HIPAA compliance.

    PubMed

    Lee, Hung-Chang; Chang, Shih-Hsin

    2012-10-01

    Security control of Electronic Medical Record (EMR) is a mechanism used to manage electronic medical records files and protect sensitive medical records document from information leakage. Researches proposed the Role-Based Access Control(RBAC). However, with the increasing scale of medical institutions, the access control behavior is difficult to have a detailed declaration among roles in RBAC. Furthermore, with the stringent specifications such as the U.S. HIPAA and Canada PIPEDA etc., patients are encouraged to have the right in regulating the access control of his EMR. In response to these problems, we propose an EMR digital rights management system, which is a RBAC-based extension to a matrix organization of medical institutions, known as RBAC-Matrix. With the aim of authorizing the EMR among roles in the organization, RBAC-Matrix also allow patients to be involved in defining access rights of his records. RBAC-Matrix authorizes access control declaration among matrix organizations of medical institutions by using XrML file in association with each EMR. It processes XrML rights declaration file-based authorization of behavior in the two-stage design, called master & servant stage, thus makes the associated EMR to be better protected. RBAC-Matrix will also make medical record file and its associated XrML declaration to two different EMRA(EMR Authorization)roles, namely, the medical records Document Creator (DC) and the medical records Document Right Setting (DRS). Access right setting, determined by the DRS, is cosigned by the patient, thus make the declaration of rights and the use of EMR to comply with HIPAA specifications.

  20. Numerical Modeling on Two phase Fluid flow in a Coupled Fracture-Skin-Matrix System

    NASA Astrophysics Data System (ADS)

    Valsala Kumari, R.; G, S. K.

    2015-12-01

    Multiphase flow modeling studies below the ground surface is very essential for designing suitable remediation strategies for contaminated aquifers and for the development of petroleum and geothermal reservoirs. Presence of fractured bedrock beneath the ground surface will make multiphase flow process more complex due to its highly heterogeneous nature. A major challenge in modeling flow within a fractured rock is to capture the interaction between the high permeability fracture and the low permeability rock-matrix. In some instances, weathering and mineral depositions will lead to formation of an additional layer named fracture-skin at the fracture-matrix interface. Porosity and permeability of fracture-skin may significantly vary from the adjacent rock matrix and this variation will result in different flow and transport behavior within the fracture-skin. In the present study, an attempt has been made to model simultaneous flow of two immiscible phases (water and LNAPL) in a saturated coupled fracture-skin-matrix system. A fully-implicit finite difference model has been developed to simulate the variation of pressure and saturation of fluid phases along the fracture and within the rock-matrix. Sensitivity studies have been done to analyze the effect of change of various fracture-skin parameters such as porosity, diffusion coefficient and thickness on pressure and saturation distribution of both wetting and non-wetting fluid phases. It can be concluded from the study that the presence of fracture-skin is significantly affecting the fluid flow at the fracture-matrix interface and it can also be seen from the study that the flow behavior of both fluid phases is sensitive to fracture-skin parameters.

  1. A fast experimental beam hardening correction method for accurate bone mineral measurements in 3D μCT imaging system.

    PubMed

    Koubar, Khodor; Bekaert, Virgile; Brasse, David; Laquerriere, Patrice

    2015-06-01

    Bone mineral density plays an important role in the determination of bone strength and fracture risks. Consequently, it is very important to obtain accurate bone mineral density measurements. The microcomputerized tomography system provides 3D information about the architectural properties of bone. Quantitative analysis accuracy is decreased by the presence of artefacts in the reconstructed images, mainly due to beam hardening artefacts (such as cupping artefacts). In this paper, we introduced a new beam hardening correction method based on a postreconstruction technique performed with the use of off-line water and bone linearization curves experimentally calculated aiming to take into account the nonhomogeneity in the scanned animal. In order to evaluate the mass correction rate, calibration line has been carried out to convert the reconstructed linear attenuation coefficient into bone masses. The presented correction method was then applied on a multimaterial cylindrical phantom and on mouse skeleton images. Mass correction rate up to 18% between uncorrected and corrected images were obtained as well as a remarkable improvement of a calculated mouse femur mass has been noticed. Results were also compared to those obtained when using the simple water linearization technique which does not take into account the nonhomogeneity in the object.

  2. Development and Validation of a Fast, Accurate and Cost-Effective Aeroservoelastic Method on Advanced Parallel Computing Systems

    NASA Technical Reports Server (NTRS)

    Goodwin, Sabine A.; Raj, P.

    1999-01-01

    Progress to date towards the development and validation of a fast, accurate and cost-effective aeroelastic method for advanced parallel computing platforms such as the IBM SP2 and the SGI Origin 2000 is presented in this paper. The ENSAERO code, developed at the NASA-Ames Research Center has been selected for this effort. The code allows for the computation of aeroelastic responses by simultaneously integrating the Euler or Navier-Stokes equations and the modal structural equations of motion. To assess the computational performance and accuracy of the ENSAERO code, this paper reports the results of the Navier-Stokes simulations of the transonic flow over a flexible aeroelastic wing body configuration. In addition, a forced harmonic oscillation analysis in the frequency domain and an analysis in the time domain are done on a wing undergoing a rigid pitch and plunge motion. Finally, to demonstrate the ENSAERO flutter-analysis capability, aeroelastic Euler and Navier-Stokes computations on an L-1011 wind tunnel model including pylon, nacelle and empennage are underway. All computational solutions are compared with experimental data to assess the level of accuracy of ENSAERO. As the computations described above are performed, a meticulous log of computational performance in terms of wall clock time, execution speed, memory and disk storage is kept. Code scalability is also demonstrated by studying the impact of varying the number of processors on computational performance on the IBM SP2 and the Origin 2000 systems.

  3. Discrete time transfer matrix method for dynamics of multibody system with flexible beams moving in space

    NASA Astrophysics Data System (ADS)

    Rui, Xiao-Ting; Kreuzer, Edwin; Rong, Bao; He, Bin

    2012-04-01

    In this paper, by defining new state vectors and developing new transfer matrices of various elements moving in space, the discrete time transfer matrix method of multi-rigid-flexible-body system is expanded to study the dynamics of multibody system with flexible beams moving in space. Formulations and numerical example of a rigid-flexible-body three pendulums system moving in space are given to validate the method. Using the new method to study the dynamics of multi-rigid-flexible-body system moving in space, the global dynamics equations of system are not needed, the orders of involved matrices of the system are very low and the computational speed is high, irrespective of the size of the system. The new method is simple, straightforward, practical, and provides a powerful tool for multi-rigid-flexible-body system dynamics.

  4. Recent advances in thermal desorption-gas chromatography-mass spectrometery method to eliminate the matrix effect between air and water samples: application to the accurate determination of Henry's law constant.

    PubMed

    Kim, Yong-Hyun; Kim, Ki-Hyun

    2014-05-16

    Accurate values for the Henry's law constants are essential to describe the environmental dynamics of a solute, but substantial errors are recognized in many reported data due to practical difficulties in measuring solubility and/or vapor pressure. Despite such awareness, validation of experimental approaches has scarcely been made. An experimental approach based on thermal desorption-gas chromatography-mass spectrometery (TD-GC-MS) method was developed to concurrently allow the accurate determination of target compounds from the headspace and aqueous samples in closed equilibrated system. The analysis of six aromatics and eight non-aromatic oxygenates was then carried out in a static headspace mode. An estimation of the potential bias and mass balance (i.e., sum of mass measured individually from gas and liquid phases vs. the mass initially added to the system) demonstrates compound-specific phase dependency so that the best results are obtained by aqueous (less soluble aromatics) and headspace analysis (more soluble non-aromatics). Accordingly, we were able to point to the possible sources of biases in previous studies and provide the best estimates for the Henry's constants (Matm(-1)): benzene (0.17), toluene (0.15), p-xylene (0.13), m-xylene (0.13), o-xylene (0.19), styrene (0.27); propionaldehyde (9.26), butyraldehyde (6.19), isovaleraldehyde (2.14), n-valeraldehyde (3.98), methyl ethyl ketone (10.5), methyl isobutyl ketone (3.93), n-butyl acetate (2.41), and isobutyl alcohol (22.2).

  5. Recent advances in thermal desorption-gas chromatography-mass spectrometery method to eliminate the matrix effect between air and water samples: application to the accurate determination of Henry's law constant.

    PubMed

    Kim, Yong-Hyun; Kim, Ki-Hyun

    2014-05-16

    Accurate values for the Henry's law constants are essential to describe the environmental dynamics of a solute, but substantial errors are recognized in many reported data due to practical difficulties in measuring solubility and/or vapor pressure. Despite such awareness, validation of experimental approaches has scarcely been made. An experimental approach based on thermal desorption-gas chromatography-mass spectrometery (TD-GC-MS) method was developed to concurrently allow the accurate determination of target compounds from the headspace and aqueous samples in closed equilibrated system. The analysis of six aromatics and eight non-aromatic oxygenates was then carried out in a static headspace mode. An estimation of the potential bias and mass balance (i.e., sum of mass measured individually from gas and liquid phases vs. the mass initially added to the system) demonstrates compound-specific phase dependency so that the best results are obtained by aqueous (less soluble aromatics) and headspace analysis (more soluble non-aromatics). Accordingly, we were able to point to the possible sources of biases in previous studies and provide the best estimates for the Henry's constants (Matm(-1)): benzene (0.17), toluene (0.15), p-xylene (0.13), m-xylene (0.13), o-xylene (0.19), styrene (0.27); propionaldehyde (9.26), butyraldehyde (6.19), isovaleraldehyde (2.14), n-valeraldehyde (3.98), methyl ethyl ketone (10.5), methyl isobutyl ketone (3.93), n-butyl acetate (2.41), and isobutyl alcohol (22.2). PMID:24704185

  6. Implementation of parallel matrix decomposition for NIKE3D on the KSR1 system

    SciTech Connect

    Su, Philip S.; Fulton, R.E.; Zacharia, T.

    1995-06-01

    New massively parallel computer architecture has revolutionized the design of computer algorithms and promises to have significant influence on algorithms for engineering computations. Realistic engineering problems using finite element analysis typically imply excessively large computational requirements. Parallel supercomputers that have the potential for significantly increasing calculation speeds can meet these computational requirements. This report explores the potential for the parallel Cholesky (U{sup T}DU) matrix decomposition algorithm on NIKE3D through actual computations. The examples of two- and three-dimensional nonlinear dynamic finite element problems are presented on the Kendall Square Research (KSR1) multiprocessor system, with 64 processors, at Oak Ridge National Laboratory. The numerical results indicate that the parallel Cholesky (U{sup T}DU) matrix decomposition algorithm is attractive for NIKE3D under multi-processor system environments.

  7. High-Frequency CTD Measurements for Accurate GPS/acoustic Sea-floor Crustal Deformation Measurement System

    NASA Astrophysics Data System (ADS)

    Tadokoro, K.; Yasuda, K.; Taniguchi, S.; Uemura, Y.; Matsuhiro, K.

    2015-12-01

    The GPS/acoustic sea-floor crustal deformation measurement system has developed as a useful tool to observe tectonic deformation especially at subduction zones. One of the factors preventing accurate GPS/acoustic sea-floor crustal deformation measurement is horizontal heterogeneity of sound speed in the ocean. It is therefore necessary to measure the gradient directly from sound speed structure. We report results of high-frequency CTD measurements using Underway CTD (UCTD) in the Kuroshio region. We perform the UCTD measurements on May 2nd, 2015 at two stations (TCA and TOA) above the sea-floor benchmarks installed across the Nankai Trough, off the south-east of Kii Peninsula, middle Japan. The number of measurement points is six at each station along circles with a diameter of 1.8 nautical miles around the sea-floor benchmark. The stations TCA and TOA are located on the edge and the interior of the Kuroshio current, respectively, judging from difference in sea water density measured at the two stations, as well as a satellite image of sea-surface temperature distribution. We detect a sound speed gradient of high speeds in the southern part and low speeds in the northern part at the two stations. At the TCA station, the gradient is noticeable down to 300 m in depth; the maximum difference in sound speed is +/- 5 m/s. The sound speed difference is as small as +/- 1.3 m/s at depths below 300 m, which causes seafloor benchmark positioning error as large as 1 m. At the TOA station, the gradient is extremely small down to 100 m in depth. The maximum difference in sound speed is less than +/- 0.3 m/s that is negligible small for seafloor benchmark positioning error. Clear gradient of high speed is observed to the depths; the maximum difference in sound speed is +/- 0.8-0.9 m/s, causing seafloor benchmark positioning error of several tens centimeters. The UCTD measurement is effective tool to detect sound speed gradient. We establish a method for accurate sea

  8. Accurate spin-orbit and spin-other-orbit contributions to the g-tensor for transition metal containing systems.

    PubMed

    Van Yperen-De Deyne, A; Pauwels, E; Van Speybroeck, V; Waroquier, M

    2012-08-14

    In this paper an overview is presented of several approximations within Density Functional Theory (DFT) to calculate g-tensors in transition metal containing systems and a new accurate description of the spin-other-orbit contribution for high spin systems is suggested. Various implementations in a broad variety of software packages (ORCA, ADF, Gaussian, CP2K, GIPAW and BAND) are critically assessed on various aspects including (i) non-relativistic versus relativistic Hamiltonians, (ii) spin-orbit coupling contributions and (iii) the gauge. Particular attention is given to the level of accuracy that can be achieved for codes that allow g-tensor calculations under periodic boundary conditions, as these are ideally suited to efficiently describe extended condensed-phase systems containing transition metals. In periodic codes like CP2K and GIPAW, the g-tensor calculation schemes currently suffer from an incorrect treatment of the exchange spin-orbit interaction and a deficient description of the spin-other-orbit term. In this paper a protocol is proposed, making the predictions of the exchange part to the g-tensor shift more plausible. Focus is also put on the influence of the spin-other-orbit interaction which becomes of higher importance for high-spin systems. In a revisited derivation of the various terms arising from the two-electron spin-orbit and spin-other-orbit interaction (SOO), new insight has been obtained revealing amongst other issues new terms for the SOO contribution. The periodic CP2K code has been adapted in view of this new development. One of the objectives of this study is indeed a serious enhancement of the performance of periodic codes in predicting g-tensors in transition metal containing systems at the same level of accuracy as the most advanced but time consuming spin-orbit mean-field approach. The methods are first applied on rhodium carbide but afterwards extended to a broad test set of molecules containing transition metals from the fourth

  9. Thin Film Heat Flux Sensor Development for Ceramic Matrix Composite (CMC) Systems

    NASA Technical Reports Server (NTRS)

    Wrbanek, John D.; Fralick, Gustave C.; Hunter, Gary W.; Zhu, Dongming; Laster, Kimala L.; Gonzalez, Jose M.; Gregory, Otto J.

    2010-01-01

    The NASA Glenn Research Center (GRC) has an on-going effort for developing high temperature thin film sensors for advanced turbine engine components. Stable, high temperature thin film ceramic thermocouples have been demonstrated in the lab, and novel methods of fabricating sensors have been developed. To fabricate thin film heat flux sensors for Ceramic Matrix Composite (CMC) systems, the rough and porous nature of the CMC system posed a significant challenge for patterning the fine features required. The status of the effort to develop thin film heat flux sensors specifically for use on silicon carbide (SiC) CMC systems with these new technologies is described.

  10. Novel Control for Voltage Boosted Matrix Converter based Wind Energy Conversion System with Practicality

    NASA Astrophysics Data System (ADS)

    Kumar, Vinod; Joshi, Raghuveer Raj; Yadav, Dinesh Kumar; Garg, Rahul Kumar

    2016-06-01

    This paper presents the implementation and investigation of novel voltage boosted matrix converter (MC) based permanent magnet wind energy conversion system (WECS). In this paper, on-line tuned adaptive fuzzy control algorithm cooperated with reversed MC is proposed to yield maximum energy. The control system is implemented on a dSPACE DS1104 real time board. Feasibility of the proposed system has been experimentally verified using a laboratory 1.2 kW prototype of WECS under steady-state and dynamic conditions.

  11. Operational Experience with the Scattering Matrix Arc Detection System on the JET ITER-Like Antenna

    SciTech Connect

    Vrancken, M.; Lerche, E.; Dumortier, P.; Durodie, F.; Evrard, M.; Huygen, S.; Ongena, J.; Van Eester, D.; Van Schoor, M.; Vervier, M.; Weynants, R.

    2009-11-26

    The Scattering Matrix Arc Detection System (SMAD) has been fully deployed on all 4 sets of Resonant Double Loop (RDL), Vacuum Transmission Line (VTL) and Antenna Pressurised Transmission Lines (APTL) of the JET ICRF ITER-Like Antenna (ILA) and this has been indispensable for operating at low (real) T-point impedance values to investigate ELM tolerance. This paper describes the necessity of the SMAD vs VSWR (Voltage Standing Wave Ratio) protection system, SMAD commissioning, problems and a number of typical events detected by the SMAD system during operation on plasma.

  12. Near real time, accurate, and sensitive microbiological safety monitoring using an all-fibre spectroscopic fluorescence system

    NASA Astrophysics Data System (ADS)

    Vanholsbeeck, F.; Swift, S.; Cheng, M.; Bogomolny, E.

    2013-11-01

    Enumeration of microorganisms is an essential microbiological task for many industrial sectors and research fields. Various tests for detection and counting of microorganisms are used today. However most of the current methods to enumerate bacteria require either long incubation time for limited accuracy, or use complicated protocols along with bulky equipment. We have developed an accurate, all-fibre spectroscopic system to measure fluorescence signal in-situ. In this paper, we examine the potential of this setup for near real time bacteria enumeration in aquatic environment. The concept is based on a well-known phenomenon that the fluorescence quantum yields of some nucleic acid stains significantly increase upon binding with nucleic acids of microorganisms. In addition we have used GFP labeled organisms. The fluorescence signal increase can be correlated to the amount of nucleic acid present in the sample. In addition we have used GFP labeled organisms. Our results show that we are able to detect a wide range of bacteria concentrations without dilution or filtration (1-108 CFU/ml) using different optical probes we designed. This high sensitivity is due to efficient light delivery with an appropriate collection volume and in situ fluorescence detection as well as the use of a sensitive CCD spectrometer. By monitoring the laser power, we can account for laser fluctuations while measuring the fluorescence signal which improves as well the system accuracy. A synchronized laser shutter allows us to achieve a high SNR with minimal integration time, thereby reducing the photobleaching effect. In summary, we conclude that our optical setup may offer a robust method for near real time bacterial detection in aquatic environment.

  13. Baseline Design Compliance Matrix for the Rotary Mode Core Sampling System

    SciTech Connect

    LECHELT, J.A.

    2000-10-17

    The purpose of the design compliance matrix (DCM) is to provide a single-source document of all design requirements associated with the fifteen subsystems that make up the rotary mode core sampling (RMCS) system. It is intended to be the baseline requirement document for the RMCS system and to be used in governing all future design and design verification activities associated with it. This document is the DCM for the RMCS system used on Hanford single-shell radioactive waste storage tanks. This includes the Exhauster System, Rotary Mode Core Sample Trucks, Universal Sampling System, Diesel Generator System, Distribution Trailer, X-Ray Cart System, Breathing Air Compressor, Nitrogen Supply Trailer, Casks and Cask Truck, Service Trailer, Core Sampling Riser Equipment, Core Sampling Support Trucks, Foot Clamp, Ramps and Platforms and Purged Camera System. Excluded items are tools such as light plants and light stands. Other items such as the breather inlet filter are covered by a different design baseline. In this case, the inlet breather filter is covered by the Tank Farms Design Compliance Matrix.

  14. Matrix metalloproteinase 9 polymorphisms and systemic lupus erythematosus: correlation with systemic inflammatory markers and oxidative stress.

    PubMed

    Bahrehmand, F; Vaisi-Raygani, A; Kiani, A; Rahimi, Z; Tavilani, H; Ardalan, M; Vaisi-Raygani, H; Shakiba, E; Pourmotabbed, T

    2015-05-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organs and is characterized by persistent systemic inflammation. Among the effects of inflammatory mediators, the induction of matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) and oxidative stress has been demonstrated to be important in the development of SLE. In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, stress, and inflammatory markers with development of severe cardiovascular disease (CVD), high blood pressure (HBP), and lupus nephropathy (LN) in SLE patients was investigated. The present case-control study consisted of 109 SLE patients with and without CVD, HBP and LN and 101 gender- and age-matched unrelated healthy controls from a population in western Iran. MMP-2 -G1575A and MMP-9 -C1562T polymorphisms were detected by PCR-RFLP, serum MMP-2 and MMP-9, neopterin, malondialdehyde (MDA) and lipid levels were determined by ELISA, HPLC and enzyme assay, respectively. We found that MMP-9 -C1562 T and MMP-2 -G1575A alleles act synergistically to increase the risk of SLE by 2.98 times (p = 0.015). Findings of this study also demonstrated that there is a significant increase in the serum levels of MMP-2, neopterin and MDA and a significant decrease in serum level of MMP-9 in the presence of MMP-9-C1562 T and MMP-2 -G1575A alleles in SLE patients compared to controls. Further, SLE patients with MMP-9 (C/T + T/T) genotype had significantly higher serum concentrations of MMP-2, neopterin, MDA and LDL-C, but lower serum MMP-9 and HDL-C levels than corresponding members of the control group. MMP-9 (C/T + T/T) genotype increased risk of hypertension in SLE patients 2.71-fold. This study for the first time not only suggests that MMP-9 -C1562 T and MMP-2 -G1575A alleles synergistically increase the risk of SLE but also high serum levels of MDA, neopterin, and circulatory levels of MMP-2 and lower MMP-9 in SLE patients. This

  15. System matrix analysis for sparse-view iterative image reconstruction in X-ray CT.

    PubMed

    Wang, Linyuan; Zhang, Hanming; Cai, Ailong; Li, Yongl; Yan, Bin; Li, Lei; Hu, Guoen

    2015-01-01

    Iterative image reconstruction (IIR) with sparsity-exploiting methods, such as total variation (TV) minimization, used for investigations in compressive sensing (CS) claim potentially large reductions in sampling requirements. Quantifying this claim for computed tomography (CT) is non-trivial, as both the singularity of undersampled reconstruction and the sufficient view number for sparse-view reconstruction are ill-defined. In this paper, the singular value decomposition method is used to study the condition number and singularity of the system matrix and the regularized matrix. An estimation method of the empirical lower bound is proposed, which is helpful for estimating the number of projection views required for exact reconstruction. Simulation studies show that the singularity of the system matrices for different projection views is effectively reduced by regularization. Computing the condition number of a regularized matrix is necessary to provide a reference for evaluating the singularity and recovery potential of reconstruction algorithms using regularization. The empirical lower bound is helpful for estimating the projections view number with a sparse reconstruction algorithm. PMID:25567402

  16. Fundamental matrix estimation for binocular vision measuring system used in wild field

    NASA Astrophysics Data System (ADS)

    Yan, Nian; Wang, Xiangjun; Liu, Feng

    2014-11-01

    A method has been proposed to estimate the fundamental matrix of a positing and monitoring binocular vision system with a long working distance and a large field of view. Because of the long working distance and large field of view, images grabbed by this system are seriously blurred, leading to a lack of local features. The edge points are acquired using the Canny algorithm firstly, then the pre-matched points are obtained by the GMM-based points sets registration algorithm, and eventually the fundamental matrix are estimated using the RANSAC algorithm. In actual application, two cameras are 2km away from the object, the fundamental matrix are figured out, and the distance between each point and the corresponding epipolar line is less than 0.8 pixel. Repeated experiments indicate that the average distances between the points and the corresponding epipolar lines are all within 0.3 pixel and the deviations of the distances are all within 0.3 pixel too. This method takes full advantage of the edges in the environment and does not need extra control points, whats more, it can work well in low SNR images.

  17. An explicit matrix formulation of the dynamical equations for flexible multibody systems - A recursive approach

    NASA Astrophysics Data System (ADS)

    Amirouche, F. M. L.; Xie, M.

    1993-01-01

    The dynamic simulation of complex rigid/flexible multibody systems relies greatly on the presentation and development of the equations of motion. To achieve computational speed in the execution and to further develop the control algorithms, the expressions involved in the kinematics and the subsequent coefficients associated with the equations of motion must be clearly defined. The intention of this paper is to develop a recursive formulation based on finite element method where all terms are presented in a matrix form. The methodology permits one to identify the coupling between rigid and flexible body motion, and build the necessary arrays for the application at hand. The equations of motion are based on Kane's equation and the general matrix representation for n bodies of its partial velocities and partial angular velocities. The algorithm developed is applied to a single two-link robot manipulator and the subsequent explicit equations of motion are presented.

  18. Systems and methods for commutating inductor current using a matrix converter

    DOEpatents

    Ransom, Ray M; Kajouke, Lateef A; Perisic, Milun

    2012-10-16

    Systems and methods are provided for delivering current using a matrix converter in a vehicle. An electrical system comprises an AC interface, a first conversion module coupled to the AC interface, an inductive element coupled between the AC interface and the first conversion module, and a control module coupled to the first conversion module. The control module is configured to operate the first conversion module in a bidirectional operating mode to commutate current bidirectionally. When a magnitude of the current through the inductive element is greater than a first threshold value, the control module operates the conversion module in a unidirectional operating mode, wherein current is commutated unidirectionally.

  19. Production of metal matrix composite mirrors for tank fire control systems

    NASA Astrophysics Data System (ADS)

    Geiger, Alan L.; Ulph, Eric, Sr.

    1992-09-01

    The first production lot of 50 units of metal matrix composite mirrors for the Leopard I tank fire control system was recently completed by Optical Corporation of America (OCA), Garden Grove, California. The mirror substrates were finish machined from forgings of Optical Grade SXATM metal matrix composite manufactured by Advanced Composite Materials Corporation (ACMC), Greer, South Carolina. Use of forgings rather than hot pressed billet yields more efficient use of material and reduces machining time, resulting in lower cost. The mirrors were fabricated by a process sequence of machining, thermal stabilization, electroless nickel plating, polishing, and coating with a high efficiency, laser damage-resistant optical coating. The mirrors are used in the fire control system for a day channel (direct view) and near infrared (CCD), a muzzle reference system laser transceiver, a laser range finder, and an infrared thermal imaging system. SXA composite was chosen over competitive mirror materials (glass and beryllium) because of its high specific strength and stiffness, good stability, and moderate machining cost. The mirrors exhibit excellent stability and optical performance. Field trials of prototype mirrors in fire control systems have proven successful.

  20. Tissue matrix arrays for high throughput screening and systems analysis of cell function

    PubMed Central

    Beachley, Vince Z.; Wolf, Matthew T.; Sadtler, Kaitlyn; Manda, Srikanth S.; Jacobs, Heather; Blatchley, Michael; Bader, Joel S.; Pandey, Akhilesh; Pardoll, Drew; Elisseeff, Jennifer H.

    2015-01-01

    Cell and protein arrays have demonstrated remarkable utility in the high-throughput evaluation of biological responses; however, they lack the complexity of native tissue and organs. Here, we describe tissue extracellular matrix (ECM) arrays for screening biological outputs and systems analysis. We spotted processed tissue ECM particles as two-dimensional arrays or incorporated them with cells to generate three-dimensional cell-matrix microtissue arrays. We then investigated the response of human stem, cancer, and immune cells to tissue ECM arrays originating from 11 different tissues, and validated the 2D and 3D arrays as representative of the in vivo microenvironment through quantitative analysis of tissue-specific cellular responses, including matrix production, adhesion and proliferation, and morphological changes following culture. The biological outputs correlated with tissue proteomics, and network analysis identified several proteins linked to cell function. Our methodology enables broad screening of ECMs to connect tissue-specific composition with biological activity, providing a new resource for biomaterials research and translation. PMID:26480475

  1. Temperature Stability and Bioadhesive Properties of Δ9-Tetrahydrocannabinol Incorporated Hydroxypropylcellulose Polymer Matrix Systems

    PubMed Central

    Repka, Michael A.; Munjal, Manish; ElSohly, Mahmoud A.; Ross, Samir A.

    2010-01-01

    The purpose of this study was to determine and compare the bioadhesive profiles of hydroxypropylcellulose (HPC) polymer matrices as a function of Δ9-tetrahydrocannabinol (THC) content. In addition, the effect of processing temperature on the stability of THC and its extent of degradation to cannabinol (CBN) was investigated. A hot-melt cast molding method was used to prepare HPC polymer matrix systems incorporated with THC at 0, 4, 8, and 16 percent. Bioadhesive measurements including peak adhesive force, area under the curve, and elongation at adhesive failure were recorded utilizing the TA.XT2i Texture Analyzer™. Data obtained from these tests at various contact time intervals suggested that the incorporation of THC led to an increase in the bioadhesive strength of the HPC polymer matrices. To determine the stability of THC and the resulting CBN content in the matrices, three different processing temperatures were utilized (120, 160, and 200°C). Post-production High Performance Liquid Chromotography (HPLC) analysis revealed that the processed systems contained at least 94% of THC and the relative percent formation of CBN was 0.5% at 120°C and 0.4% at 160°C compared to 1.6% at 200°C. These findings indicate that the cannabinoid may be a plausible candidate for incorporation into systems utilizing hot-melt extrusion techniques for the development of an effective mucoadhesive transmucosal matrix system for delivery of THC. PMID:16455601

  2. A network and visual quality aware N-screen content recommender system using joint matrix factorization.

    PubMed

    Ullah, Farman; Sarwar, Ghulam; Lee, Sungchang

    2014-01-01

    We propose a network and visual quality aware N-Screen content recommender system. N-Screen provides more ways than ever before to access multimedia content through multiple devices and heterogeneous access networks. The heterogeneity of devices and access networks present new questions of QoS (quality of service) in the realm of user experience with content. We propose, a recommender system that ensures a better visual quality on user's N-screen devices and the efficient utilization of available access network bandwidth with user preferences. The proposed system estimates the available bandwidth and visual quality on users N-Screen devices and integrates it with users preferences and contents genre information to personalize his N-Screen content. The objective is to recommend content that the user's N-Screen device and access network are capable of displaying and streaming with the user preferences that have not been supported in existing systems. Furthermore, we suggest a joint matrix factorization approach to jointly factorize the users rating matrix with the users N-Screen device similarity and program genres similarity. Finally, the experimental results show that we also enhance the prediction and recommendation accuracy, sparsity, and cold start issues.

  3. A Network and Visual Quality Aware N-Screen Content Recommender System Using Joint Matrix Factorization

    PubMed Central

    Ullah, Farman; Sarwar, Ghulam; Lee, Sungchang

    2014-01-01

    We propose a network and visual quality aware N-Screen content recommender system. N-Screen provides more ways than ever before to access multimedia content through multiple devices and heterogeneous access networks. The heterogeneity of devices and access networks present new questions of QoS (quality of service) in the realm of user experience with content. We propose, a recommender system that ensures a better visual quality on user's N-screen devices and the efficient utilization of available access network bandwidth with user preferences. The proposed system estimates the available bandwidth and visual quality on users N-Screen devices and integrates it with users preferences and contents genre information to personalize his N-Screen content. The objective is to recommend content that the user's N-Screen device and access network are capable of displaying and streaming with the user preferences that have not been supported in existing systems. Furthermore, we suggest a joint matrix factorization approach to jointly factorize the users rating matrix with the users N-Screen device similarity and program genres similarity. Finally, the experimental results show that we also enhance the prediction and recommendation accuracy, sparsity, and cold start issues. PMID:24982999

  4. Realizing Low-Energy Classification Systems by Implementing Matrix Multiplication Directly Within an ADC.

    PubMed

    Wang, Zhuo; Zhang, Jintao; Verma, Naveen

    2015-12-01

    In wearable and implantable medical-sensor applications, low-energy classification systems are of importance for deriving high-quality inferences locally within the device. Given that sensor instrumentation is typically followed by A-D conversion, this paper presents a system implementation wherein the majority of the computations required for classification are implemented within the ADC. To achieve this, first an algorithmic formulation is presented that combines linear feature extraction and classification into a single matrix transformation. Second, a matrix-multiplying ADC (MMADC) is presented that enables multiplication between an analog input sample and a digital multiplier, with negligible additional energy beyond that required for A-D conversion. Two systems mapped to the MMADC are demonstrated: (1) an ECG-based cardiac arrhythmia detector; and (2) an image-pixel-based facial gender detector. The RMS error over all multiplication performed, normalized to the RMS of ideal multiplication results is 0.018. Further, compared to idealized versions of conventional systems, the energy savings obtained are estimated to be 13× and 29×, respectively, while achieving similar level of performance. PMID:26849205

  5. Development of an unmanned aerial vehicle-based spray system for highly accurate site-specific application

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Application of crop production and protection materials is a crucial component in the high productivity of American agriculture. Agricultural chemical application is frequently needed at a specific time and location for accurate site-specific management of crop pests. Piloted aircrafts that carry ...

  6. A Charrelation Matrix-Based Blind Adaptive Detector for DS-CDMA Systems.

    PubMed

    Luo, Zhongqiang; Zhu, Lidong

    2015-01-01

    In this paper, a blind adaptive detector is proposed for blind separation of user signals and blind estimation of spreading sequences in DS-CDMA systems. The blind separation scheme exploits a charrelation matrix for simple computation and effective extraction of information from observation signal samples. The system model of DS-CDMA signals is modeled as a blind separation framework. The unknown user information and spreading sequence of DS-CDMA systems can be estimated only from the sampled observation signals. Theoretical analysis and simulation results show that the improved performance of the proposed algorithm in comparison with the existing conventional algorithms used in DS-CDMA systems. Especially, the proposed scheme is suitable for when the number of observation samples is less and the signal to noise ratio (SNR) is low. PMID:26287209

  7. A Charrelation Matrix-Based Blind Adaptive Detector for DS-CDMA Systems.

    PubMed

    Luo, Zhongqiang; Zhu, Lidong

    2015-08-14

    In this paper, a blind adaptive detector is proposed for blind separation of user signals and blind estimation of spreading sequences in DS-CDMA systems. The blind separation scheme exploits a charrelation matrix for simple computation and effective extraction of information from observation signal samples. The system model of DS-CDMA signals is modeled as a blind separation framework. The unknown user information and spreading sequence of DS-CDMA systems can be estimated only from the sampled observation signals. Theoretical analysis and simulation results show that the improved performance of the proposed algorithm in comparison with the existing conventional algorithms used in DS-CDMA systems. Especially, the proposed scheme is suitable for when the number of observation samples is less and the signal to noise ratio (SNR) is low.

  8. A Charrelation Matrix-Based Blind Adaptive Detector for DS-CDMA Systems

    PubMed Central

    Luo, Zhongqiang; Zhu, Lidong

    2015-01-01

    In this paper, a blind adaptive detector is proposed for blind separation of user signals and blind estimation of spreading sequences in DS-CDMA systems. The blind separation scheme exploits a charrelation matrix for simple computation and effective extraction of information from observation signal samples. The system model of DS-CDMA signals is modeled as a blind separation framework. The unknown user information and spreading sequence of DS-CDMA systems can be estimated only from the sampled observation signals. Theoretical analysis and simulation results show that the improved performance of the proposed algorithm in comparison with the existing conventional algorithms used in DS-CDMA systems. Especially, the proposed scheme is suitable for when the number of observation samples is less and the signal to noise ratio (SNR) is low. PMID:26287209

  9. Differentiation of Aeromonas isolated from drinking water distribution systems using matrix-assisted laser desorption/ionization-mass spectrometry.

    PubMed

    Donohue, Maura J; Best, Jennifer M; Smallwood, Anthony W; Kostich, Mitchell; Rodgers, Mark; Shoemaker, Jody A

    2007-03-01

    The genus Aeromonas is one of several medically significant genera that have gained prominence due to their evolving taxonomy and controversial role in human diseases. In this study, matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) was used to analyze the whole cells of both reference strains and unknown Aeromonas isolates obtained from water distribution systems. A library of over 45 unique m/z signatures was created from 40 strains that are representative of the 17 recognized species of Aeromonas, as well as 3 reference strains from genus Vibrio and 2 reference strains from Plesiomonas shigelloides. The library was used to help speciate 52 isolates of Aeromonas. The environmental isolates were broken up into 2 blind studies. Group 1 contained isolates that had a recognizable phenotypic profile and group 2 contained isolates that had an atypical phenotypic profile. MALDI-MS analysis of the water isolates in group 1 matched the phenotypic identification in all cases. In group 2, the MALDI-MS-based determination confirmed the identity of 18 of the 27 isolates. These results demonstrate that MALDI-MS analysis can rapidly and accurately classify species of the genus Aeromonas, making it a powerful tool especially suited for environmental monitoring and detection of microbial hazards in drinking water.

  10. Discrete time transfer matrix method for dynamics of multibody system with real-time control

    NASA Astrophysics Data System (ADS)

    Rong, Bao; Rui, Xiaoting; Wang, Guoping; Yang, Fufeng

    2010-03-01

    By taking the control and feedback parameters into account in state vectors, defining new state vectors and deducing new transfer equations and transfer matrices for actuator, controlled element and feedback element, a new method named as the discrete time transfer matrix method for controlled multibody system (CMS) is developed to study dynamics of CMS with real-time control in this paper. This method does not need the global dynamics equations of system. It has the modeling flexibility, low order of system matrix, high computational efficiency, and is efficient for general CMS. Compared with the ordinary dynamics methods, the proposed method has more advantages for dynamics design and real-time control of a complex CMS. Adopting the PID adaptive controller and modal velocity feedback control on PZT actuators, and applying the proposed method and ordinary dynamics method, respectively, the tip trajectory tracking for a flexible manipulator is carried out. Formulations of the method as well as numerical simulation are given to validate the proposed method.

  11. Extracellular matrix-inspired growth factor delivery systems for bone regeneration

    SciTech Connect

    Martino, Mikaël M.; Briquez, Priscilla S.; Maruyama, Kenta; Hubbell, Jeffrey A.

    2015-04-17

    Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiological doses of growth factor used without optimized delivery systems. Therefore, these issues have motivated the development of new delivery systems allowing better control of the spatio-temporal release and signaling of growth factors. Because the extracellular matrix (ECM) naturally plays a fundamental role in coordinating growth factor activity in vivo, a number of novel delivery systems have been inspired by the growth factor regulatory function of the ECM. After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.

  12. Extracellular matrix-inspired growth factor delivery systems for bone regeneration.

    PubMed

    Martino, Mikaël M; Briquez, Priscilla S; Maruyama, Kenta; Hubbell, Jeffrey A

    2015-11-01

    Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiological doses of growth factor used without optimized delivery systems. Therefore, these issues have motivated the development of new delivery systems allowing better control of the spatiotemporal release and signaling of growth factors. Because the extracellular matrix (ECM) naturally plays a fundamental role in coordinating growth factor activity in vivo, a number of novel delivery systems have been inspired by the growth factor regulatory function of the ECM. After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.

  13. Development of new and improved polymer matrix resin systems, phase 1

    NASA Technical Reports Server (NTRS)

    Hsu, M. S.

    1983-01-01

    Vinystilbazole (vinylstryrylpyridine) and vinylpolystyrulpyridine were prepared for the purpose of modifying bismaleimide composite resins. Cure studies of resins systems were investigated by differential scanning calorimetry. The vinylstyrylpyridine-modified bismaleimide composite resins were found to have lower cure and gel temperatures, and shorter cure times than the corresponding unmodified composite resins. The resin systems were reinforced with commercially avialable satin-weave carbon cloth. Prepregs were fabricated by solvent or hot melt techniques. Thermal stability, flammability, moisture absorption, and mechanical properties of the composites (such as flexural strength, modulus, tensile and short beam shear strength) were determined. Composite laminates showed substantial improvements in both processability and mechanical properties compared to he bismaleimide control systems. The vinylstyrylpyridine modified bismaleimide resins can be used as advanced matrix resins for graphite secondary structures where ease of processing, fireworthiness, and high temperature stability are required for aerospace applications.

  14. PET image reconstruction with a system matrix containing point spread function derived from single photon incidence response

    NASA Astrophysics Data System (ADS)

    Fan, Xin; Wang, Hai-Peng; Yun, Ming-Kai; Sun, Xiao-Li; Cao, Xue-Xiang; Liu, Shuang-Quan; Chai, Pei; Li, Dao-Wu; Liu, Bao-Dong; Wang, Lu; Wei, Long

    2015-01-01

    A point spread function (PSF) for the blurring component in positron emission tomography (PET) is studied. The PSF matrix is derived from the single photon incidence response function. A statistical iterative reconstruction (IR) method based on the system matrix containing the PSF is developed. More specifically, the gamma photon incidence upon a crystal array is simulated by Monte Carlo (MC) simulation, and then the single photon incidence response functions are calculated. Subsequently, the single photon incidence response functions are used to compute the coincidence blurring factor according to the physical process of PET coincidence detection. Through weighting the ordinary system matrix response by the coincidence blurring factors, the IR system matrix containing the PSF is finally established. By using this system matrix, the image is reconstructed by an ordered subset expectation maximization (OSEM) algorithm. The experimental results show that the proposed system matrix can substantially improve the image radial resolution, contrast, and noise property. Furthermore, the simulated single gamma-ray incidence response function depends only on the crystal configuration, so the method could be extended to any PET scanner with the same detector crystal configuration. Project supported by the National Natural Science Foundation of China (Grant Nos. Y4811H805C and 81101175).

  15. The Application of Metal Matrix Composite Materials in Propulsion System Valves

    NASA Technical Reports Server (NTRS)

    Laszar, John; Shah, Sandeep; Kashalikar, Uday; Rozenoyer, Boris

    2003-01-01

    Metal Matrix Composite (MMC) materials have been developed and used in many applications to reduce the weight of components where weight and deflection are the driving design requirement. MMC materials are being developed for use in some propulsion system components, such as turbo-pumps and thrust chambers. However, to date, no propulsion system valves have been developed that take advantage of the materials unique properties. The stiffness of MMC's could help keep valves light or improve life where deflection is the design constraint (such as seal and bearing locations). The low CTE of the materials might allow the designer to reduce tolerances and clearances producing better performance and lighter weight valves. Using unique manufacturing processes allow parts to be plated/coated for longer life and allow joining either by welding or threading/bolting. Additionally, casting of multi part pre-forms to form a single part can lead to designs that would be hard or impossible to manufacture with other methods. Therefore, NASA's Marshall Space Flight Center (MSFC) has developed and tested a prototype propulsion system valve that utilizes these materials to demonstrate these advantages. Through design and testing, this effort will determine the best use of these materials in valves designed to achieve the goal of a highly reliable and lightweight propulsion system. This paper is a continuation of the paper, The Application of Metal Matrix Composite Materials In Propulsion System Valves, presented at the JANNAF Conference held in April, 2002. Fabrication techniques employed, valve development, and valve test results will be discussed in this paper.

  16. Bone Matrix Turnover And Balance In Vitro

    PubMed Central

    Flanagan, Barry; Nichols, George

    1969-01-01

    Labeled proline from incubation media has been shown to be incorporated into living bone matrix collagen in vitro. Hydroxyproline is released from fresh bone slices in similar systems in a characteristic curve against time. This hydroxyproline is derived from three distinct sources, each of which may be separately quantitated. Part of the total represents passive solubilization of matrix collagen, part is derived from new synthesis of soluble collagen occurring in vitro, and the remainder is released by cell-mediated resorptive action. The latter two processes are linear with time up to 8 hr; the former decays to zero at about 2 hr. Consequently, rates of collagen synthesis and of new collagen deposition and resorption can be quantitated simultaneously in the same system. The ability to measure these parameters of bone collagen metabolism provides methods both for the accurate evaluation of organic matrix resorption in vitro and for the accurate measurement of rates of collagen synthesis and collagen deposition. The application of the method is illustrated using parathyroid hormone and thyrocalcitonin. Parathyroid hormone diminishes collagen synthesis and stimulates collagen resorption. It reduces slightly the deposition of newly formed collagen in stable matrix. The net effect of these changes is to produce a marked negative balance. It does not significantly affect the solubility of matrix collagen. Thyrocalcitonin does not affect collagen synthesis or its deposition. It causes a marked fall in resorption rate. It has no effect on matrix collagen solubility. The net effect is to produce a marked positive balance of matrix collagen. Images PMID:5774102

  17. Reduced-density-matrix description for pump-probe optical phenomena in moving atomic systems

    NASA Astrophysics Data System (ADS)

    Jacobs, V. L.

    2014-09-01

    Linear and nonlinear (especially coherent) electromagnetic interactions of moving many-electron atoms are investigated using a reduced-density-matrix description, which is applied to electromagnetically induced transparency and related resonant pump-probe optical phenomena. External magnetic fields are included on an equal footing with the electromagnetic fields and spin-Zeeman interactions are taken into account. Complimentary time-domain (equation-of-motion) and frequency-domain (resolvent-operator) formulations of the reduced-density-matrix description are self-consistently developed. The general nonperturbative and non-Markovian formulations provide a fundamental framework for systematic evaluations of corrections to the standard Born (lowest-order-perturbation) and Markov (short-memory-time) approximations. The macroscopic electromagnetic response is described semiclassically, employing a perturbation expansion of the reduced-density operator in powers of the classical electromagnetic field. Our primary results are compact Liouville-space operator expressions for the linear and general (nth-order) nonlinear macroscopic electromagnetic-response tensors, which can be evaluated for nonlocal and nonstationary optical media described by multilevel atomic-system representations. Interactions among atoms and with environmental photons are treated as line-broadening effects by means of a general Liouville-space self-energy operator, for which the tetradic-matrix elements are explicitly evaluated in the diagonal, lowest-order, and Markov approximations. The compact Liouville-space operator expressions that are derived for the macroscopic electromagnetic-response tensors are introduced into the dynamical description of the electromagnetic-field propagation. It is pointed out that a quantized-electromagnetic-field approach will be required for a fully self-consistent quantum-mechanical treatment of local-field effects and radiative corrections.

  18. Recent Applications Of Metal Matrix Composites In Precision Instruments And Optical Systems

    NASA Astrophysics Data System (ADS)

    Mohn, Walter R.; Vukobratovich, Daniel

    1988-02-01

    This paper describes three unique metal matrix composite (MMC) material systems that have been developed for use in dimensionally stable platforms, precision mechanical systems, and lightweight reflective optics. These engineered materials, consisting of aluminum alloys reinforced with fine particles of silicon carbide, offer distinctive performance advantages over conventional metals, including greater specific stiffness, higher strength, and better resistance to compressive microcreep. Weighing about the same as aluminum, certain grades of these MMC materials are isotropic and have excellent thermal conductivity, and they can be tailored to match the coefficients of thermal expansion of other materials, including beryllium, stainless steel, and electroless nickel. Such flexibilities in establishing material properties and characteristics present new opportunities to the designer in producing weight-critical, precision hardware. Practical applications of MMC materials in advanced guidance equipment and lightweight optical assemblies are presented and discussed.

  19. Accurate potential energy functions, non-adiabatic and spin-orbit couplings in the ZnH(+) system.

    PubMed

    Liang, Guiying; Liu, Xiaoting; Zhang, Xiaomei; Xu, Haifeng; Yan, Bing

    2016-03-01

    A high-level ab initio calculation on the ZnH(+) cation has been carried out with the multi-reference configuration interaction method plus Davison correction (MRCI+Q). The scalar relativistic effect is included by using the Douglas-Kroll-Hess (DKH) method. The calculated potential energy curves (PECs) of the 7 Λ-S states are associated with the dissociation limits of Zn(+)((2)Sg)+H((2)Sg), Zn((1)Sg)+H(+)((1)Sg), and Zn(+)((2)Pu)+H((2)Sg), respectively (The Λ-S state is labeled as (2S+1)Λ, in which Λ is the quantum number for the projection along the internuclear axis of the total electronic orbital angular momentum and S is the total electron spin). The spectroscopic constants of the bound states are determined and in good agreement with the available theoretical and experimental results. The permanent dipole moments (PDMs) of Λ-S states and the spin-orbit (SO) matrix elements between Λ-S states are also computed. The results show that the abrupt changes of the PDMs and SO matrix elements come into being for the reason of the avoided crossing between the states with the same symmetry. In addition, the non-adiabatic couplings matrix elements between Λ-S states are also evaluated. Finally, the spin-orbit couplings (SOCs) for the low-lying states are considered with Breit-Pauli operator. The SOC effect makes the 7 Λ-S states of the ZnH(+) cation split into 12 Ω states (Ω=Λ+Sz, in which Sz is projection of the total electron spin S along the internuclear Z-axis). For the (3)0(+) state, the two energy minima exhibit in the potential, which could be attributed to the formation of the new avoided crossing point. The transition dipole moments (TDMs), Franck-Condon factors, and the radiative lifetimes of the selected transitions (2)0(+)-X0(+), (3)0(+)-X0(+), (2)1-X0(+) and (3)1-X0(+) have been reported.

  20. Accurate potential energy functions, non-adiabatic and spin-orbit couplings in the ZnH+ system

    NASA Astrophysics Data System (ADS)

    Liang, Guiying; Liu, Xiaoting; Zhang, Xiaomei; Xu, Haifeng; Yan, Bing

    2016-03-01

    A high-level ab initio calculation on the ZnH+ cation has been carried out with the multi-reference configuration interaction method plus Davison correction (MRCI + Q). The scalar relativistic effect is included by using the Douglas-Kroll-Hess (DKH) method. The calculated potential energy curves (PECs) of the 7 Λ-S states are associated with the dissociation limits of Zn+(2Sg) + H(2Sg), Zn(1Sg) + H+(1Sg), and Zn+(2Pu) + H(2Sg), respectively (The Λ-S state is labeled as 2S + 1Λ, in which Λ is the quantum number for the projection along the internuclear axis of the total electronic orbital angular momentum and S is the total electron spin). The spectroscopic constants of the bound states are determined and in good agreement with the available theoretical and experimental results. The permanent dipole moments (PDMs) of Λ-S states and the spin-orbit (SO) matrix elements between Λ-S states are also computed. The results show that the abrupt changes of the PDMs and SO matrix elements come into being for the reason of the avoided crossing between the states with the same symmetry. In addition, the non-adiabatic couplings matrix elements between Λ-S states are also evaluated. Finally, the spin-orbit couplings (SOCs) for the low-lying states are considered with Breit-Pauli operator. The SOC effect makes the 7 Λ-S states of the ZnH+ cation split into 12 Ω states (Ω = Λ + Sz, in which Sz is projection of the total electron spin S along the internuclear Z-axis). For the (3)0+ state, the two energy minima exhibit in the potential, which could be attributed to the formation of the new avoided crossing point. The transition dipole moments (TDMs), Franck-Condon factors, and the radiative lifetimes of the selected transitions (2)0+-X0+, (3)0+-X0+, (2)1-X0+ and (3)1-X0+ have been reported.

  1. Simplified LCA and matrix methods in identifying the environmental aspects of a product system.

    PubMed

    Hur, Tak; Lee, Jiyong; Ryu, Jiyeon; Kwon, Eunsun

    2005-05-01

    In order to effectively integrate environmental attributes into the product design and development processes, it is crucial to identify the significant environmental aspects related to a product system within a relatively short period of time. In this study, the usefulness of life cycle assessment (LCA) and a matrix method as tools for identifying the key environmental issues of a product system were examined. For this, a simplified LCA (SLCA) method that can be applied to Electrical and Electronic Equipment (EEE) was developed to efficiently identify their significant environmental aspects for eco-design, since a full scale LCA study is usually very detailed, expensive and time-consuming. The environmentally responsible product assessment (ERPA) method, which is one of the matrix methods, was also analyzed. Then, the usefulness of each method in eco-design processes was evaluated and compared using the case studies of the cellular phone and vacuum cleaner systems. It was found that the SLCA and the ERPA methods provided different information but they complemented each other to some extent. The SLCA method generated more information on the inherent environmental characteristics of a product system so that it might be useful for new design/eco-innovation when developing a completely new product or method where environmental considerations play a major role from the beginning. On the other hand, the ERPA method gave more information on the potential for improving a product so that it could be effectively used in eco-redesign which intends to alleviate environmental impacts of an existing product or process.

  2. Simplified LCA and matrix methods in identifying the environmental aspects of a product system.

    PubMed

    Hur, Tak; Lee, Jiyong; Ryu, Jiyeon; Kwon, Eunsun

    2005-05-01

    In order to effectively integrate environmental attributes into the product design and development processes, it is crucial to identify the significant environmental aspects related to a product system within a relatively short period of time. In this study, the usefulness of life cycle assessment (LCA) and a matrix method as tools for identifying the key environmental issues of a product system were examined. For this, a simplified LCA (SLCA) method that can be applied to Electrical and Electronic Equipment (EEE) was developed to efficiently identify their significant environmental aspects for eco-design, since a full scale LCA study is usually very detailed, expensive and time-consuming. The environmentally responsible product assessment (ERPA) method, which is one of the matrix methods, was also analyzed. Then, the usefulness of each method in eco-design processes was evaluated and compared using the case studies of the cellular phone and vacuum cleaner systems. It was found that the SLCA and the ERPA methods provided different information but they complemented each other to some extent. The SLCA method generated more information on the inherent environmental characteristics of a product system so that it might be useful for new design/eco-innovation when developing a completely new product or method where environmental considerations play a major role from the beginning. On the other hand, the ERPA method gave more information on the potential for improving a product so that it could be effectively used in eco-redesign which intends to alleviate environmental impacts of an existing product or process. PMID:15829365

  3. Matrix equation decomposition and parallel solution of systems resulting from unstructured finite element problems in electromagnetics

    SciTech Connect

    Cwik, T.; Katz, D.S.

    1996-12-31

    Finite element modeling has proven useful for accurately simulating scattered or radiated electromagnetic fields from complex three-dimensional objects whose geometry varies on the scale of a fraction of an electrical wavelength. An unstructured finite element model of realistic objects leads to a large, sparse, system of equations that needs to be solved efficiently with regard to machine memory and execution time. Both factorization and iterative solvers can be used to produce solutions to these systems of equations. Factorization leads to high memory requirements that limit the electrical problem size of three-dimensional objects that can be modeled. An iterative solver can be used to efficiently solve the system without excessive memory use and in a minimal amount of time if the convergence rate is controlled.

  4. Fast iterative image reconstruction using sparse matrix factorization with GPU acceleration

    NASA Astrophysics Data System (ADS)

    Zhou, Jian; Qi, Jinyi

    2011-03-01

    Statistically based iterative approaches for image reconstruction have gained much attention in medical imaging. An accurate system matrix that defines the mapping from the image space to the data space is the key to high-resolution image reconstruction. However, an accurate system matrix is often associated with high computational cost and huge storage requirement. Here we present a method to address this problem by using sparse matrix factorization and parallel computing on a graphic processing unit (GPU).We factor the accurate system matrix into three sparse matrices: a sinogram blurring matrix, a geometric projection matrix, and an image blurring matrix. The sinogram blurring matrix models the detector response. The geometric projection matrix is based on a simple line integral model. The image blurring matrix is to compensate for the line-of-response (LOR) degradation due to the simplified geometric projection matrix. The geometric projection matrix is precomputed, while the sinogram and image blurring matrices are estimated by minimizing the difference between the factored system matrix and the original system matrix. The resulting factored system matrix has much less number of nonzero elements than the original system matrix and thus substantially reduces the storage and computation cost. The smaller size also allows an efficient implement of the forward and back projectors on GPUs, which have limited amount of memory. Our simulation studies show that the proposed method can dramatically reduce the computation cost of high-resolution iterative image reconstruction. The proposed technique is applicable to image reconstruction for different imaging modalities, including x-ray CT, PET, and SPECT.

  5. All-order renormalization of the propagator matrix for fermionic systems with flavor mixing.

    PubMed

    Kniehl, Bernd A

    2014-02-21

    We consider a mixed system of Dirac fermions in a general parity-nonconserving theory and renormalize the propagator matrix to all orders in the pole scheme, in which the squares of the renormalized masses are identified with the complex pole positions and the wave-function renormalization (WFR) matrices are adjusted in compliance with the Lehmann-Symanzik-Zimmermann reduction formalism. We present closed analytic all-order expressions and their expansions through two loops for the renormalization constants in terms of the scalar, pseudoscalar, vector, and pseudovector parts of the unrenormalized self-energy matrix, which is computable from the one-particle-irreducible Feynman diagrams of the flavor transitions. We identify residual degrees of freedom in the WFR matrices and propose an additional renormalization condition to exhaust them. We then explain how our results may be generalized to the case of unstable fermions, in which we encounter the phenomenon of WFR bifurcation. In the special case of a solitary unstable fermion, the all-order-renormalized propagator is presented in a particularly compact form. PMID:24579589

  6. Effects of processing on the release profiles of matrix systems containing 5-aminosalicylic acid.

    PubMed

    Korbely, Anita; Kelemen, András; Kása, Péter; Pintye-Hódi, Klára

    2012-12-01

    The aim of this study was to investigate the influence of different processing methods on the profiles of 5-aminosalicylic acid dissolution from controlled-release matrix systems based on Eudragit® RL and Eudragit® RS water-insoluble polymers. The pure polymers and their mixtures were studied as matrix formers using different processing methods, i.e., direct compression, wet granulation of the active ingredient with the addition of polymer(s) to the external phase, wet granulation with water, and wet granulation with aqueous dispersions. In comparison with the directly compressed tablets, tablets made by wet granulation with water demonstrated a 6-19% increase in final drug dissolution, whereas when polymers were applied in the external phase during compression, a 0-13% decrease was observed in the amount of drug released. Wet granulation with aqueous polymer dispersions delayed the release of the drug; this was especially marked (a 54-56% decrease in drug release) in compositions, which contained a high amount of Eudragit RL 30D. The release profiles were mostly described by the Korsmeyer-Peppas model or the Hopfenberg model. PMID:23054987

  7. Organization of the channel-switching process in parallel computer systems based on a matrix optical switch

    NASA Technical Reports Server (NTRS)

    Golomidov, Y. V.; Li, S. K.; Popov, S. A.; Smolov, V. B.

    1986-01-01

    After a classification and analysis of electronic and optoelectronic switching devices, the design principles and structure of a matrix optical switch is described. The switching and pair-exclusion operations in this type of switch are examined, and a method for the optical switching of communication channels is elaborated. Finally, attention is given to the structural organization of a parallel computer system with a matrix optical switch.

  8. Statistics of time delay and scattering correlation functions in chaotic systems. I. Random matrix theory

    SciTech Connect

    Novaes, Marcel

    2015-06-15

    We consider the statistics of time delay in a chaotic cavity having M open channels, in the absence of time-reversal invariance. In the random matrix theory approach, we compute the average value of polynomial functions of the time delay matrix Q = − iħS{sup †}dS/dE, where S is the scattering matrix. Our results do not assume M to be large. In a companion paper, we develop a semiclassical approximation to S-matrix correlation functions, from which the statistics of Q can also be derived. Together, these papers contribute to establishing the conjectured equivalence between the random matrix and the semiclassical approaches.

  9. Accurate determination of genetic identity for a single cacao bean, using molecular markers with a nanofluidic system, ensures cocoa authentication.

    PubMed

    Fang, Wanping; Meinhardt, Lyndel W; Mischke, Sue; Bellato, Cláudia M; Motilal, Lambert; Zhang, Dapeng

    2014-01-15

    Cacao (Theobroma cacao L.), the source of cocoa, is an economically important tropical crop. One problem with the premium cacao market is contamination with off-types adulterating raw premium material. Accurate determination of the genetic identity of single cacao beans is essential for ensuring cocoa authentication. Using nanofluidic single nucleotide polymorphism (SNP) genotyping with 48 SNP markers, we generated SNP fingerprints for small quantities of DNA extracted from the seed coat of single cacao beans. On the basis of the SNP profiles, we identified an assumed adulterant variety, which was unambiguously distinguished from the authentic beans by multilocus matching. Assignment tests based on both Bayesian clustering analysis and allele frequency clearly separated all 30 authentic samples from the non-authentic samples. Distance-based principle coordinate analysis further supported these results. The nanofluidic SNP protocol, together with forensic statistical tools, is sufficiently robust to establish authentication and to verify gourmet cacao varieties. This method shows significant potential for practical application.

  10. Matrix product states for anyonic systems and efficient simulation of dynamics

    NASA Astrophysics Data System (ADS)

    Singh, Sukhwinder; Pfeifer, Robert N. C.; Vidal, Guifre; Brennen, Gavin K.

    2014-02-01

    Matrix product states (MPS) have proven to be a very successful tool to study lattice systems with local degrees of freedom such as spins or bosons. Topologically ordered systems can support anyonic particles which are labeled by conserved topological charges and collectively carry nonlocal degrees of freedom. In this paper we extend the formalism of MPS to lattice systems of anyons. The anyonic MPS is constructed from tensors that explicitly conserve topological charge. We describe how to adapt the time-evolving block decimation (TEBD) algorithm to the anyonic MPS in order to simulate dynamics under a local and charge-conserving Hamiltonian. To demonstrate the effectiveness of the anyonic TEBD algorithm, we used it to simulate (i) the ground state (using imaginary time evolution) of an infinite one dimensional critical system of (a) Ising anyons and (b) Fibonacci anyons, both of which are well studied, and (ii) the real time dynamics of an anyonic Hubbard-like model of a single Ising anyon hopping on a ladder geometry with an anyonic flux threading each island of the ladder. Our results pertaining to (ii) give insight into the transport properties of anyons. The anyonic MPS formalism can be readily adapted to study systems with conserved symmetry charges, as this is equivalent to a specialization of the more general anyonic case.

  11. A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis

    PubMed Central

    Tressel, Sarah L; Kaneider, Nicole C; Kasuda, Shogo; Foley, Caitlin; Koukos, Georgios; Austin, Karyn; Agarwal, Anika; Covic, Lidija; Opal, Steven M; Kuliopulos, Athan

    2011-01-01

    Sepsis is a deadly disease characterized by the inability to regulate the inflammatory–coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorly understood and has hampered the development of effective therapeutics. Matrix metalloproteases (MMPs) are involved in the host response to pathogens, but can also cause uncontrolled tissue damage and contribute to mortality. We found that human sepsis patients had markedly elevated plasma proMMP-1 and active MMP-1 levels, which correlated with death at 7 and 28 days after diagnosis. Likewise, septic mice had increased plasma levels of the MMP-1 ortholog, MMP-1a. We identified mouse MMP-1a as an agonist of protease-activated receptor-1 (PAR1) on endothelial cells. MMP-1a was released from endothelial cells in septic mice. Blockade of MMP-1 activity suppressed endothelial barrier disruption, disseminated intravascular coagulation (DIC), lung vascular permeability as well as the cytokine storm and improved survival, which was lost in PAR1-deficient mice. Infusion of human MMP-1 increased lung vascular permeability in normal wild-type mice but not in PAR1-deficient mice. These findings implicate MMP-1 as an important activator of PAR1 in sepsis and suggest that therapeutics that target MMP1-PAR1 may prove beneficial in the treatment of sepsis. PMID:21591259

  12. Extraction of food consumption systems by nonnegative matrix factorization (NMF) for the assessment of food choices.

    PubMed

    Zetlaoui, Mélanie; Feinberg, Max; Verger, Philippe; Clémençon, Stephan

    2011-12-01

    In Western countries where food supply is satisfactory, consumers organize their diets around a large combination of foods. It is the purpose of this article to examine how recent nonnegative matrix factorization (NMF) techniques can be applied to food consumption data to understand these combinations. Such data are nonnegative by nature and of high dimension. The NMF model provides a representation of consumption data through latent vectors with nonnegative coefficients, that we call consumption systems (CS), in a small number. As the NMF approach may encourage sparsity of the data representation produced, the resulting CS are easily interpretable. Beyond the illustration of its properties we provide through a simple simulation result, the NMF method is applied to data issued from a French consumption survey. The numerical results thus obtained are displayed and thoroughly discussed. A clustering based on the k-means method is also achieved in the resulting latent consumption space, to recover food consumption patterns easily usable for nutritionists. PMID:21418050

  13. Reduced Density Matrix and Entanglement Entropy of Permutationally Invariant Quantum Many-Body Systems

    NASA Astrophysics Data System (ADS)

    Popkov, Vladislav; Salerno, Mario

    2013-06-01

    In this paper we discuss the properties of the reduced density matrix of quantum many body systems with permutational symmetry and present basic quantification of the entanglement in terms of the von Neumann (VNE), Renyi and Tsallis entropies. In particular, we show, on the specific example of the spin 1/2 Heisenberg model, how the RDM acquires a block diagonal form with respect to the quantum number k fixing the polarization in the subsystem conservation of Sz and with respect to the irreducible representations of the Sn group. Analytical expression for the RDM elements and for the RDM spectrum are derived for states of arbitrary permutational symmetry and for arbitrary polarizations. The temperature dependence and scaling of the VNE across a finite temperature phase transition is discussed and the RDM moments and the Rényi and Tsallis entropies calculated both for symmetric ground states of the Heisenberg chain and for maximally mixed states.

  14. Reduced Density Matrix and Entanglement Entropy of Permutationally Invariant Quantum Many-Body Systems

    NASA Astrophysics Data System (ADS)

    Popkov, Vladislav; Salerno, Mario

    2012-11-01

    In this paper we discuss the properties of the reduced density matrix of quantum many body systems with permutational symmetry and present basic quantification of the entanglement in terms of the von Neumann (VNE), Renyi and Tsallis entropies. In particular, we show, on the specific example of the spin 1/2 Heisenberg model, how the RDM acquires a block diagonal form with respect to the quantum number k fixing the polarization in the subsystem conservation of Sz and with respect to the irreducible representations of the Sn group. Analytical expression for the RDM elements and for the RDM spectrum are derived for states of arbitrary permutational symmetry and for arbitrary polarizations. The temperature dependence and scaling of the VNE across a finite temperature phase transition is discussed and the RDM moments and the Rényi and Tsallis entropies calculated both for symmetric ground states of the Heisenberg chain and for maximally mixed states.

  15. Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes.

    PubMed

    Huang, Hai; Kornberg, Thomas B

    2016-01-01

    Drosophila dorsal air sac development depends on Decapentaplegic (Dpp) and Fibroblast growth factor (FGF) proteins produced by the wing imaginal disc and transported by cytonemes to the air sac primordium (ASP). Dpp and FGF signaling in the ASP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp- nor FGF-receiving cytonemes extended over mutant disc cells that lacked them. ASP cytonemes normally navigate through extracellular matrix (ECM) composed of collagen, laminin, Dally and Dally-like (Dlp) proteins that are stratified in layers over the disc cells. However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally). These findings suggest that cytonemes interact directly and specifically with proteins in the stratified ECM. PMID:27591355

  16. Optimum Co-Design for Spectrum Sharing between Matrix Completion Based MIMO Radars and a MIMO Communication System

    NASA Astrophysics Data System (ADS)

    Li, Bo; Petropulu, Athina P.; Trappe, Wade

    2016-09-01

    Recently proposed multiple input multiple output radars based on matrix completion (MIMO-MC) employ sparse sampling to reduce the amount of data that need to be forwarded to the radar fusion center, and as such enable savings in communication power and bandwidth. This paper proposes designs that optimize the sharing of spectrum between a MIMO-MC radar and a communication system, so that the latter interferes minimally with the former. First, the communication system transmit covariance matrix is designed to minimize the effective interference power (EIP) to the radar receiver, while maintaining certain average capacity and transmit power for the communication system. Two approaches are proposed, namely a noncooperative and a cooperative approach, with the latter being applicable when the radar sampling scheme is known at the communication system. Second, a joint design of the communication transmit covariance matrix and the MIMO-MC radar sampling scheme is proposed, which achieves even further EIP reduction.

  17. Dipole transition matrix elements for systems with power-law potentials

    SciTech Connect

    Grant, A.K.; Rosner, J.L. )

    1992-11-01

    We study the behavior of dipole matrix elements for systems bound by power-law potentials of the form {ital V}({ital r}){similar to}{ital r}{sup {alpha}}, which are useful in the descriptions of quarkonium systems. The experimental feature for which further understanding is sought is the apparent suppression of the transition {Upsilon}(3{ital S}){r arrow}{chi}{sub {ital b}}{gamma}. We find that this matrix element actually vanishes in a power-law potential {ital r}{sup {alpha}} for a certain power {alpha}{sub 0}{approx}{minus}0.4. The suppression of transitions between states with different numbers of nodes in their radial wave functions is a universal property of most physically interesting power-law potentials. We derive results in the limit of large orbital angular momenta {ital l}, checking that they agree with the known answers for the Coulomb and spherical oscillator potentials. For states with {ital n}{sub {ital r}} nodes in their radial wave functions, we find that the matrix elements {l angle}{ital n}{sub {ital r}},{ital l}{vert bar}{ital r}{vert bar}{ital n}{sub {ital r}},{ital l}+1{r angle} behave as {ital l}{sup 2/(2+{alpha})} for small {ital n}{sub {ital r}} and large {ital l}. Transitions with {Delta}{ital n}{sub {ital r}}={plus minus}1 behave with respect to those with {Delta}{ital n}{sub {ital r}}=0 as const/ {radical}{ital l}, with constants calculated for each {ital n}{sub {ital r}}. Moreover, we find that {l angle}{ital n}{sub {ital r}}=0,{ital l}{vert bar}{ital r}{vert bar}{ital n}{sub {ital r}}=2,{ital l}{minus}1{r angle}/{l angle}{ital n}{sub {ital r}}=0, {ital l}{vert bar}{ital r}{vert bar}{ital n}{sub {ital r}}=0,{ital l}+1{r angle}{r arrow}{Phi}({alpha})/{ital l} as {ital l}{r arrow}{infinity}, where {Phi}({alpha}) is calculated explicitly.

  18. Matrix light and pixel light: optical system architecture and requirements to the light source

    NASA Astrophysics Data System (ADS)

    Spinger, Benno; Timinger, Andreas L.

    2015-09-01

    Modern Automotive headlamps enable improved functionality for more driving comfort and safety. Matrix or Pixel light headlamps are not restricted to either pure low beam functionality or pure high beam. Light in direction of oncoming traffic is selectively switched of, potential hazard can be marked via an isolated beam and the illumination on the road can even follow a bend. The optical architectures that enable these advanced functionalities are diverse. Electromechanical shutters and lens units moved by electric motors were the first ways to realize these systems. Switching multiple LED light sources is a more elegant and mechanically robust solution. While many basic functionalities can already be realized with a limited number of LEDs, an increasing number of pixels will lead to more driving comfort and better visibility. The required optical system needs not only to generate a desired beam distribution with a high angular dynamic, but also needs to guarantee minimal stray light and cross talk between the different pixels. The direct projection of the LED array via a lens is a simple but not very efficient optical system. We discuss different optical elements for pre-collimating the light with minimal cross talk and improved contrast between neighboring pixels. Depending on the selected optical system, we derive the basic light source requirements: luminance, surface area, contrast, flux and color homogeneity.

  19. Closed-form solutions for linear regulator design of mechanical systems including optimal weighting matrix selection

    NASA Technical Reports Server (NTRS)

    Hanks, Brantley R.; Skelton, Robert E.

    1991-01-01

    Vibration in modern structural and mechanical systems can be reduced in amplitude by increasing stiffness, redistributing stiffness and mass, and/or adding damping if design techniques are available to do so. Linear Quadratic Regulator (LQR) theory in modern multivariable control design, attacks the general dissipative elastic system design problem in a global formulation. The optimal design, however, allows electronic connections and phase relations which are not physically practical or possible in passive structural-mechanical devices. The restriction of LQR solutions (to the Algebraic Riccati Equation) to design spaces which can be implemented as passive structural members and/or dampers is addressed. A general closed-form solution to the optimal free-decay control problem is presented which is tailored for structural-mechanical system. The solution includes, as subsets, special cases such as the Rayleigh Dissipation Function and total energy. Weighting matrix selection is a constrained choice among several parameters to obtain desired physical relationships. The closed-form solution is also applicable to active control design for systems where perfect, collocated actuator-sensor pairs exist.

  20. Misfit-induced changes of lattice parameters in two-phase systems: coherent/incoherent precipitates in a matrix

    PubMed Central

    Akhlaghi, Maryam; Steiner, Tobias; Meka, Sai Ramudu; Mittemeijer, Eric Jan

    2016-01-01

    Elastic accommodation of precipitation-induced or thermally induced misfit leads to lattice-parameter changes in crystalline multi-phase systems. Formulae for calculation of such misfit-induced lattice-parameter changes are presented for the aggregate (matrix + second-phase particles) and for the individual matrix and second phase, recognizing the occurrence of either coherent or incoherent diffraction by the matrix and second-phase particles. An overview and an (re)interpretation on the above basis is presented of published lattice-parameter data, obtained by X-ray diffraction analyses of aggregates of matrix plus second-phase particles. Examples for three types of systems consisting of a matrix with misfitting second-phase particles are dealt with, which differ in the origin of the misfit (precipitation or thermally induced) and in the type of diffraction (coherent or incoherent diffraction of matrix plus second-phase particles). The experimental data are shown to be in good to very good agreement with predictions according to the current treatment. PMID:26937236

  1. Generalized design of a zero-geometric-loss, astigmatism-free, modified four-objective multipass matrix system.

    PubMed

    Guo, Yin; Sun, LiQun; Yang, Zheng; Liu, Zilong

    2016-02-20

    During this study we constructed a generalized parametric modified four-objective multipass matrix system (MMS). We used an optical system comprising four asymmetrical spherical mirrors to improve the alignment process. The use of a paraxial equation for the design of the front transfer optics yielded the initial condition for modeling our MMS. We performed a ray tracing simulation to calculate the significant aberration of the system (astigmatism). Based on the calculated meridional and sagittal focus positions, the complementary focusing mirror was easily designed to provide an output beam free of astigmatism. We have presented an example of a 108-transit multipass system (5×7 matrix arrangement) with a relatively larger numerical aperture source (xenon light source). The whole system exhibits zero theoretical geometrical loss when simulated with Zemax software. The MMS construction strategy described in this study provides an anastigmatic output beam and the generalized approach to design a controllable matrix spot pattern on the field mirrors. Asymmetrical reflective mirrors aid in aligning the whole system with high efficiency. With the generalized design strategy in terms of optics configuration and asymmetrical fabrication method in this paper, other kinds of multipass matrix system coupled with different sources and detector systems also can be achieved. PMID:26906598

  2. Eigenvalue density of linear stochastic dynamical systems: A random matrix approach

    NASA Astrophysics Data System (ADS)

    Adhikari, S.; Pastur, L.; Lytova, A.; Du Bois, J.

    2012-02-01

    Eigenvalue problems play an important role in the dynamic analysis of engineering systems modeled using the theory of linear structural mechanics. When uncertainties are considered, the eigenvalue problem becomes a random eigenvalue problem. In this paper the density of the eigenvalues of a discretized continuous system with uncertainty is discussed by considering the model where the system matrices are the Wishart random matrices. An analytical expression involving the Stieltjes transform is derived for the density of the eigenvalues when the dimension of the corresponding random matrix becomes asymptotically large. The mean matrices and the dispersion parameters associated with the mass and stiffness matrices are necessary to obtain the density of the eigenvalues in the frameworks of the proposed approach. The applicability of a simple eigenvalue density function, known as the Marenko-Pastur (MP) density, is investigated. The analytical results are demonstrated by numerical examples involving a plate and the tail boom of a helicopter with uncertain properties. The new results are validated using an experiment on a vibrating plate with randomly attached spring-mass oscillators where 100 nominally identical samples are physically created and individually tested within a laboratory framework.

  3. Development of a robust once-a-day glipizide matrix system.

    PubMed

    Jamzad, Shahla; Fassihi, Reza

    2007-06-01

    The robustness of a new hydroxypropylmethylcellulose (HPMC) based modified release glipizide (10 mg) formulation was studied. The tablet formulations were prepared by dry blending the ingredients and direct compression, incorporating a range of release modifying agents up to +/-20% w/w relative to an optimized formulation. The dissolution was assessed in 900 mL pH 6.8 buffer at 75 rev min(-1) paddle speed. Calculated difference and similarity factors (f(1) and f(2)) and results of analysis of variance suggest that the overall release profiles were similar. Compositional changes up to +/-20% w/w and a reduction of drug dose to half did not change the general release pattern of this low dose/pH-dependent drug in a significant way. It is concluded that the drug release from the developed matrix systems is highly dependent on the kinetics of hydration and erosion, and that the proposed compositional changes within +/-20% w/w did not alter this relationship. The particulate systems used were characterized by determining the Carr index, Hausner ratio and the rheological properties using a texture analyser. Results indicate that the release is reproducible and the system has potential for successful scale-up operation, while complying with recommended Food and Drug Administration guidelines "Scale Up and Post Approval Changes". PMID:17637169

  4. Chaotic versus nonchaotic stochastic dynamics in Monte Carlo simulations: a route for accurate energy differences in N-body systems.

    PubMed

    Assaraf, Roland; Caffarel, Michel; Kollias, A C

    2011-04-15

    We present a method to efficiently evaluate small energy differences of two close N-body systems by employing stochastic processes having a stability versus chaos property. By using the same random noise, energy differences are computed from close trajectories without reweighting procedures. The approach is presented for quantum systems but can be applied to classical N-body systems as well. It is exemplified with diffusion Monte Carlo simulations for long chains of hydrogen atoms and molecules for which it is shown that the long-standing problem of computing energy derivatives is solved. PMID:21568537

  5. Gap between technically accurate information and socially appropriate information for structural health monitoring system installed into tall buildings

    NASA Astrophysics Data System (ADS)

    Mita, Akira

    2016-04-01

    The importance of the structural health monitoring system for tall buildings is now widely recognized by at least structural engineers and managers at large real estate companies to ensure the structural safety immediately after a large earthquake and appeal the quantitative safety of buildings to potential tenants. Some leading real estate companies decided to install the system into all tall buildings. Considering this tendency, a pilot project for the west area of Shinjuku Station supported by the Japan Science and Technology Agency was started by the author team to explore a possibility of using the system to provide safe spaces for commuters and residents. The system was installed into six tall buildings. From our experience, it turned out that viewing only from technological aspects was not sufficient for the system to be accepted and to be really useful. Safe spaces require not only the structural safety but also the soundness of key functions of the building. We need help from social scientists, medical doctors, city planners etc. to further improve the integrity of the system.

  6. Matrix Failure Modes and Effects Analysis as a Knowledge Base for a Real Time Automated Diagnosis Expert System

    NASA Technical Reports Server (NTRS)

    Herrin, Stephanie; Iverson, David; Spukovska, Lilly; Souza, Kenneth A. (Technical Monitor)

    1994-01-01

    Failure Modes and Effects Analysis contain a wealth of information that can be used to create the knowledge base required for building automated diagnostic Expert systems. A real time monitoring and diagnosis expert system based on an actual NASA project's matrix failure modes and effects analysis was developed. This Expert system Was developed at NASA Ames Research Center. This system was first used as a case study to monitor the Research Animal Holding Facility (RAHF), a Space Shuttle payload that is used to house and monitor animals in orbit so the effects of space flight and microgravity can be studied. The techniques developed for the RAHF monitoring and diagnosis Expert system are general enough to be used for monitoring and diagnosis of a variety of other systems that undergo a Matrix FMEA. This automated diagnosis system was successfully used on-line and validated on the Space Shuttle flight STS-58, mission SLS-2 in October 1993.

  7. Electrochemical Time-of-Flight in crosslinked collagen matrix solution: implications of structural changes for drug delivery systems.

    PubMed

    Ky, Darline; Liu, Chi Kin; Marumoto, Christopher; Castaneda, Luciano; Slowinska, Katarzyna

    2006-05-15

    Electrochemical Time-of-Flight (ETOF) method was used for the first time to measure the diffusion coefficient of 4-hydroxy-TEMPO, a molecular probe in collagen I matrix solution as a function of its concentration and the extent of crosslinking with glutaraldehyde (GA). The values of the diffusion coefficient were correlated with Circular Dichroism (CD) and viscosity data to assess the changes of the structure of a collagen matrix. The low value of probe diffusion coefficient indicates that the molecular collagen contributes to large diffusion hindrance of the medium. The combined Brinkman or effective medium model and the Carman-Kozeny model were used to estimate the average diameter of a matrix pore as a function of collagen solution composition. We show that 0.5% and 1% (w/w) collagen matrix crosslinked with the addition of GA above 0.1% (v/w) forms matrix with pores larger than in native collagen. This result suggests the existence of a micro-phase separation in the crosslinked collagen matrix. The implications of these findings for the design of small molecule drug delivery systems are discussed.

  8. Quaternion-based unscented Kalman filter for accurate indoor heading estimation using wearable multi-sensor system.

    PubMed

    Yuan, Xuebing; Yu, Shuai; Zhang, Shengzhi; Wang, Guoping; Liu, Sheng

    2015-01-01

    Inertial navigation based on micro-electromechanical system (MEMS) inertial measurement units (IMUs) has attracted numerous researchers due to its high reliability and independence. The heading estimation, as one of the most important parts of inertial navigation, has been a research focus in this field. Heading estimation using magnetometers is perturbed by magnetic disturbances, such as indoor concrete structures and electronic equipment. The MEMS gyroscope is also used for heading estimation. However, the accuracy of gyroscope is unreliable with time. In this paper, a wearable multi-sensor system has been designed to obtain the high-accuracy indoor heading estimation, according to a quaternion-based unscented Kalman filter (UKF) algorithm. The proposed multi-sensor system including one three-axis accelerometer, three single-axis gyroscopes, one three-axis magnetometer and one microprocessor minimizes the size and cost. The wearable multi-sensor system was fixed on waist of pedestrian and the quadrotor unmanned aerial vehicle (UAV) for heading estimation experiments in our college building. The results show that the mean heading estimation errors are less 10° and 5° to multi-sensor system fixed on waist of pedestrian and the quadrotor UAV, respectively, compared to the reference path. PMID:25961384

  9. Quaternion-Based Unscented Kalman Filter for Accurate Indoor Heading Estimation Using Wearable Multi-Sensor System

    PubMed Central

    Yuan, Xuebing; Yu, Shuai; Zhang, Shengzhi; Wang, Guoping; Liu, Sheng

    2015-01-01

    Inertial navigation based on micro-electromechanical system (MEMS) inertial measurement units (IMUs) has attracted numerous researchers due to its high reliability and independence. The heading estimation, as one of the most important parts of inertial navigation, has been a research focus in this field. Heading estimation using magnetometers is perturbed by magnetic disturbances, such as indoor concrete structures and electronic equipment. The MEMS gyroscope is also used for heading estimation. However, the accuracy of gyroscope is unreliable with time. In this paper, a wearable multi-sensor system has been designed to obtain the high-accuracy indoor heading estimation, according to a quaternion-based unscented Kalman filter (UKF) algorithm. The proposed multi-sensor system including one three-axis accelerometer, three single-axis gyroscopes, one three-axis magnetometer and one microprocessor minimizes the size and cost. The wearable multi-sensor system was fixed on waist of pedestrian and the quadrotor unmanned aerial vehicle (UAV) for heading estimation experiments in our college building. The results show that the mean heading estimation errors are less 10° and 5° to multi-sensor system fixed on waist of pedestrian and the quadrotor UAV, respectively, compared to the reference path. PMID:25961384

  10. Quaternion-based unscented Kalman filter for accurate indoor heading estimation using wearable multi-sensor system.

    PubMed

    Yuan, Xuebing; Yu, Shuai; Zhang, Shengzhi; Wang, Guoping; Liu, Sheng

    2015-05-07

    Inertial navigation based on micro-electromechanical system (MEMS) inertial measurement units (IMUs) has attracted numerous researchers due to its high reliability and independence. The heading estimation, as one of the most important parts of inertial navigation, has been a research focus in this field. Heading estimation using magnetometers is perturbed by magnetic disturbances, such as indoor concrete structures and electronic equipment. The MEMS gyroscope is also used for heading estimation. However, the accuracy of gyroscope is unreliable with time. In this paper, a wearable multi-sensor system has been designed to obtain the high-accuracy indoor heading estimation, according to a quaternion-based unscented Kalman filter (UKF) algorithm. The proposed multi-sensor system including one three-axis accelerometer, three single-axis gyroscopes, one three-axis magnetometer and one microprocessor minimizes the size and cost. The wearable multi-sensor system was fixed on waist of pedestrian and the quadrotor unmanned aerial vehicle (UAV) for heading estimation experiments in our college building. The results show that the mean heading estimation errors are less 10° and 5° to multi-sensor system fixed on waist of pedestrian and the quadrotor UAV, respectively, compared to the reference path.

  11. The density matrix renormalization group for strongly correlated electron systems: A generic implementation

    NASA Astrophysics Data System (ADS)

    Alvarez, G.

    2009-09-01

    The purpose of this paper is (i) to present a generic and fully functional implementation of the density-matrix renormalization group (DMRG) algorithm, and (ii) to describe how to write additional strongly-correlated electron models and geometries by using templated classes. Besides considering general models and geometries, the code implements Hamiltonian symmetries in a generic way and parallelization over symmetry-related matrix blocks. Program summaryProgram title: DMRG++ Catalogue identifier: AEDJ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEDJ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: See file LICENSE No. of lines in distributed program, including test data, etc.: 15 795 No. of bytes in distributed program, including test data, etc.: 83 454 Distribution format: tar.gz Programming language: C++, MPI Computer: PC, HP cluster Operating system: Any, tested on Linux Has the code been vectorized or parallelized?: Yes RAM: 1 GB (256 MB is enough to run included test) Classification: 23 External routines: BLAS and LAPACK Nature of problem: Strongly correlated electrons systems, display a broad range of important phenomena, and their study is a major area of research in condensed matter physics. In this context, model Hamiltonians are used to simulate the relevant interactions of a given compound, and the relevant degrees of freedom. These studies rely on the use of tight-binding lattice models that consider electron localization, where states on one site can be labeled by spin and orbital degrees of freedom. The calculation of properties from these Hamiltonians is a computational intensive problem, since the Hilbert space over which these Hamiltonians act grows exponentially with the number of sites on the lattice. Solution method: The DMRG is a numerical variational technique to study quantum many body Hamiltonians. For one-dimensional and quasi one-dimensional systems, the

  12. Anion photoelectron spectroscopy of acid-base systems, solvated molecules and MALDI matrix molecules

    NASA Astrophysics Data System (ADS)

    Eustis, Soren Newman

    Gas phase, mass-selected, anion photoelectron spectroscopic studies were performed on a variety of molecular systems. These studies can be grouped into three main themes: acid-base interactions, solvation, and ions of analytical interest. Acid-base interactions represent some of the most fundamental processes in chemistry. The study of these processes elucidates elementary principles such as inner and outer sphere complexes, hard and soft ions, and salt formation---to name a few. Apart from their appeal from a pedagogical standpoint, the ubiquity of chemical reactions which involve acids, bases or the resulting salts makes the study of their fundamental interactions both necessary and fruitful. With this in mind, the neutral and anionic series (NH3···HX) (X= F, Cl, Br, I) were examined experimentally and theoretically. The relatively small size of these systems, combined with the advances in computational methods, allowed our experimental results to be compared with very high level ab initio theoretical results. The synergy between theory and experiment yielded an understanding of the nature of the complexes that could not be achieved with either method in isolation. The second theme present in this body or work is molecular solvation. Solvation is a phenomenon which is present in biology, chemistry and physics. Many biological molecules do not become 'active' until they are solvated by water. Thus, the study of biologically relevant species solvated by water is one step in a bottom up approach to studying the biochemical interactions in living organisms. Furthermore, the hydration of acidic molecules in the atmosphere is what drives the formation of 'free' protons or hydronium ions which are the key players in acid driven chemistry. Here are presented two unique solvation studies, Adenine(H2O)-n and C6F6(H2O)-n, these systems are very distinct, but show somewhat similar responses to hydration. The last theme presented in this work is the electronic properties

  13. Introduction of a Photogrammetric Camera System for Rpas with Highly Accurate Gnss/imu Information for Standardized Workflows

    NASA Astrophysics Data System (ADS)

    Kraft, T.; Geßner, M.; Meißner, H.; Przybilla, H. J.; Gerke, M.

    2016-03-01

    In this paper we present the evaluation of DLR's modular airborne camera system MACS-Micro for remotely piloted aircraft system (RPAS) with a maximum takeoff weight (MTOW) less than 5kg. The main focus is on standardized calibration and test procedures as well as on standardized photogrammetric workflows as a proof of feasibility for this aerial camera concept. The prototype consists of an industrial grade frame imaging camera and a compact GNSS/IMU solution which are operated by an embedded PC. The camera has been calibrated pre- and post- flight using a three dimensional test field. The validation of the latest prototype is done by a traditional photogrammetric evaluation of an aerial survey using 39 ground control points. The results, concerning geometric and radiometric features of the present system concept as well as the quality of the aero triangulation, fulfill many of the aimed keyspecifications.

  14. Modeling multi-component transport and enhanced anaerobic dechlorination processes in a single fracture-clay matrix system.

    PubMed

    Chambon, Julie C; Broholm, Mette M; Binning, Philip J; Bjerg, Poul L

    2010-03-01

    Clayey tills contaminated with chlorinated solvents are a threat to groundwater and are difficult to remediate. A numerical model is developed for assessing leaching processes and for simulating the remediation via enhanced anaerobic dechlorination. The model simulates the transport of a contaminant in a single fracture-clay matrix system coupled with a reactive model for anaerobic dechlorination. The model takes into account microbially driven anaerobic dechlorination, where sequential Monod kinetics with competitive inhibition is used to model the reaction rates, and degradation is localized to account for potential pore size limitations on microbial entry to the clay matrix. The model is used to assess the distribution of TCE and its daughter products in the clay matrix and the concentration of the different compounds at the outlet of the fracture. The time frame for complete cleanup and the contaminant flux out of the clay system are assessed for different distributions of microbial degradation. Results from a set of scenarios show that time to remove 90% of the initial mass is halved when dechlorination occurs in a 5cm reaction zone in the clay at the fracture-matrix interface (from 419 to 195years) and decreases by an order of magnitude when dechlorination occurs in the entire matrix (to 32years). The fracture spacing and the microbial parameters are shown to be the critical parameter for estimation of time frames depending on the system in question. Generally, the system is more sensitive to the physical processes, mainly diffusion in the matrix, than to the biogeochemical processes, when dechlorination is assumed to take place in a limited reaction zone only. The inclusion of sequential dechlorination in clay fracture transport models is crucial, as the contaminant flux to the aquifer will increase as a result of degradation due to the higher mobility of the formed daughter products DCE and VC. The model is used to examine the relationship between flux

  15. The value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in identifying clinically relevant bacteria: a comparison with automated microbiology system

    PubMed Central

    Zhou, Chunmei; Huang, Shenglei; Shan, Yuzhang; Ye, Xiangru

    2014-01-01

    Background Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been developed as a new-type soft ionization mass spectrometry in the recent year. Increasing number of clinical microbiological laboratories consider it as an innovate approach for bacterial identification. Methods A total of 876 clinical strains, comprising 52 species in 27 genus, were obtained from Fudan University Affiliated Zhongshan Hospital. We compared the identification accuracy of the Vitek MS system (bioMerieux, Marcy l’Etoile) to other conventional methods for bacterial identification. 16S rRNA gene sequencing was performed as a reference identification method in cases of discrepant results. Results The Vitek MS system consistently produced accurate results within minutes of loading, while conventional methods required several hours to produce identification results. Among the 876 isolates, the overall performance of Vitek MS was significantly better than the conventional method both for correct species identification (830, 94.7% vs. 746, 85.2%, respectively, P=0.000). Conclusions Compared to traditional identification methods, MALDI-TOF MS is a rapid, accurate and economical technique to enhance the clinical value of microorganism identification. PMID:24822117

  16. Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system.

    PubMed

    Kuhn, Sam J; Hallahan, Dennis E; Giorgio, Todd D

    2006-01-01

    Controlled dispersion of therapeutic agents within liquid- and gel-filled cavities represents a barrier to treatment of some cancers and other pathological states. Interstitial delivery is compromised by the poor mobility of macromolecules and larger nanoscale structures. We developed an in vitro system to quantify the suitability of superparamagnetic nanoparticles (SPM NPs) as a site-specific therapeutic vehicle for delivery through fluid- and gel-based systems. SPM NP motion was induced by an external magnetic field. NP migration was modulated by NP concentration and surface coating. 135 nanometer radius PEGylated NPs moved through the extracellular matrix with an average velocity of 1.5 mm h(-1), suitable for some clinical applications. Increasing the SPM NP radius to 400 nm while maintaining the same per NP magnetic susceptibility resulted in a greater than 1,000-fold reduction in magnetic mobility, to less than 0.01 mm h(-1). The critical influence of NP size on gel permeation was also observed in silica-coated 135 nm SPM NPs that aggregated under the experimental conditions. Aggregation played a critical role in determining the behavior of the nanoparticles. SPM NPs allow significant free-solution mobility to specific sites within a cavity and generate sufficient force to penetrate common in vivo gels. PMID:16477503

  17. Mechanics and crack formation in the extracellular matrix with articular cartilage as a model system

    NASA Astrophysics Data System (ADS)

    Kearns, Sarah; Silverberg, Jesse; Bonassar, Lawrence; Cohen, Itai; Das, Moumita

    We investigate the mechanical structure-function relations in the extracellular matrix (ECM) with focus on crack formation and failure. As a model system, our study focuses on the ECM in articular cartilage (AC), the tissue that covers the ends of bones, and distributes load in joints including in the knees, shoulders, and hips. The strength, toughness, and crack resistance of native articular cartilage is unparalleled in materials made by humankind. This mechanical response is mainly due to its ECM. The ECM in AC has two major mechanobiological components: a network of the biopolymer collagen and a flexible aggrecan gel. We model this system as a biopolymer network embedded in a swelling gel, and investigate the conditions for the formation and propagation of cracks using a combination of rigidity percolation theory and energy minimization approaches. Our results may provide useful insights into the design principles of the ECM as well as of biomimetic hydrogels that are mechanically robust and can, at the same time, easily adapt to cues in their surroundings. This work was partially supported by a Cottrell College Science Award.

  18. Equivalence of matrix product ensembles of trajectories in open quantum systems.

    PubMed

    Kiukas, Jukka; Guţă, Mădălin; Lesanovsky, Igor; Garrahan, Juan P

    2015-07-01

    The equivalence of thermodynamic ensembles is at the heart of statistical mechanics and central to our understanding of equilibrium states of matter. Recently, a formal connection has been established between the dynamics of open quantum systems and statistical mechanics in an extra dimension: an open system dynamics generates a matrix product state (MPS) encoding all possible quantum jump trajectories which allows to construct generating functions akin to partition functions. For dynamics generated by a Lindblad master equation, the corresponding MPS is a so-called continuous MPS which encodes the set of continuous measurement records terminated at some fixed total observation time. Here, we show that if one instead terminates trajectories after a fixed total number of quantum jumps, e.g., emission events into the environment, the associated MPS is discrete. The continuous and discrete MPS correspond to different ensembles of quantum trajectories, one characterized by total time, the other by total number of quantum jumps. Hence, they give rise to quantum versions of different thermodynamic ensembles, akin to "grand canonical" and "isobaric," but for trajectories. Here, we prove that these trajectory ensembles are equivalent in a suitable limit of long time or large number of jumps. This is in direct analogy to equilibrium statistical mechanics where equivalence between ensembles is only strictly established in the thermodynamic limit. An intrinsic quantum feature is that the equivalence holds only for all observables that commute with the number of quantum jumps. PMID:26274149

  19. Crack Driving Forces in a Multilayered Coating System for Ceramic Matrix Composite Substrates

    NASA Technical Reports Server (NTRS)

    Ghosn, Louis J.; Zhu, Dongming; Miller, Robert A.

    2005-01-01

    The effects of the top coating thickness, modulus and shrinkage strains on the crack driving forces for a baseline multilayer Yttria-Stabilized-Zirconia/Mullite/Si thermal and environment barrier coating (TEBC) system for SiC/SiC ceramic matrix composite substrates are determined for gas turbine applications. The crack driving forces increase with increasing modulus, and a low modulus thermal barrier coating material (below 10 GPa) will have no cracking issues under the thermal gradient condition analyzed. Since top coating sintering increases the crack driving forces with time, highly sintering resistant coatings are desirable to maintain a low tensile modulus and maintain a low crack driving force with time. Finite element results demonstrated that an advanced TEBC system, such as ZrO2/HfO2, which possesses improved sintering resistance and high temperature stability, exhibited excellent durability. A multi-vertical cracked structure with fine columnar spacing is an ideal strain tolerant coating capable of reducing the crack driving forces to an acceptable level even with a high modulus of 50 GPa.

  20. An accurate online calibration system based on combined clamp-shape coil for high voltage electronic current transformers

    NASA Astrophysics Data System (ADS)

    Li, Zhen-hua; Li, Hong-bin; Zhang, Zhi

    2013-07-01

    Electronic transformers are widely used in power systems because of their wide bandwidth and good transient performance. However, as an emerging technology, the failure rate of electronic transformers is higher than that of traditional transformers. As a result, the calibration period needs to be shortened. Traditional calibration methods require the power of transmission line be cut off, which results in complicated operation and power off loss. This paper proposes an online calibration system which can calibrate electronic current transformers without power off. In this work, the high accuracy standard current transformer and online operation method are the key techniques. Based on the clamp-shape iron-core coil and clamp-shape air-core coil, a combined clamp-shape coil is designed as the standard current transformer. By analyzing the output characteristics of the two coils, the combined clamp-shape coil can achieve verification of the accuracy. So the accuracy of the online calibration system can be guaranteed. Moreover, by employing the earth potential working method and using two insulating rods to connect the combined clamp-shape coil to the high voltage bus, the operation becomes simple and safe. Tests in China National Center for High Voltage Measurement and field experiments show that the proposed system has a high accuracy of up to 0.05 class.

  1. An accurate online calibration system based on combined clamp-shape coil for high voltage electronic current transformers

    SciTech Connect

    Li, Zhen-hua; Li, Hong-bin; Zhang, Zhi

    2013-07-15

    Electronic transformers are widely used in power systems because of their wide bandwidth and good transient performance. However, as an emerging technology, the failure rate of electronic transformers is higher than that of traditional transformers. As a result, the calibration period needs to be shortened. Traditional calibration methods require the power of transmission line be cut off, which results in complicated operation and power off loss. This paper proposes an online calibration system which can calibrate electronic current transformers without power off. In this work, the high accuracy standard current transformer and online operation method are the key techniques. Based on the clamp-shape iron-core coil and clamp-shape air-core coil, a combined clamp-shape coil is designed as the standard current transformer. By analyzing the output characteristics of the two coils, the combined clamp-shape coil can achieve verification of the accuracy. So the accuracy of the online calibration system can be guaranteed. Moreover, by employing the earth potential working method and using two insulating rods to connect the combined clamp-shape coil to the high voltage bus, the operation becomes simple and safe. Tests in China National Center for High Voltage Measurement and field experiments show that the proposed system has a high accuracy of up to 0.05 class.

  2. An accurate online calibration system based on combined clamp-shape coil for high voltage electronic current transformers.

    PubMed

    Li, Zhen-hua; Li, Hong-bin; Zhang, Zhi

    2013-07-01

    Electronic transformers are widely used in power systems because of their wide bandwidth and good transient performance. However, as an emerging technology, the failure rate of electronic transformers is higher than that of traditional transformers. As a result, the calibration period needs to be shortened. Traditional calibration methods require the power of transmission line be cut off, which results in complicated operation and power off loss. This paper proposes an online calibration system which can calibrate electronic current transformers without power off. In this work, the high accuracy standard current transformer and online operation method are the key techniques. Based on the clamp-shape iron-core coil and clamp-shape air-core coil, a combined clamp-shape coil is designed as the standard current transformer. By analyzing the output characteristics of the two coils, the combined clamp-shape coil can achieve verification of the accuracy. So the accuracy of the online calibration system can be guaranteed. Moreover, by employing the earth potential working method and using two insulating rods to connect the combined clamp-shape coil to the high voltage bus, the operation becomes simple and safe. Tests in China National Center for High Voltage Measurement and field experiments show that the proposed system has a high accuracy of up to 0.05 class. PMID:23902112

  3. Fast and accurate calibration of an X-ray imager to an electromagnetic tracking system for interventional cardiac procedures.

    PubMed

    Lang, Andrew; Stanton, Douglas; Parthasarathy, Vijay; Jain, Ameet

    2010-01-01

    Cardiovascular disease affects millions of Americans each year. Interventional guidance systems are being developed as treatment options for some of the more delicate procedures, including targeted stem cell therapy. As advanced systems for such types of interventional guidance are being developed, electromagnetic (EM) tracking is coming in demand to perform navigation. To use this EM tracking technology, a calibration is necessary to register the tracker to the imaging system. In this paper we investigate the calibration of an X-ray imaging system to EM tracking. Two specially designed calibration phantoms have been designed for this purpose, each having a rigidly attached EM sensor. From a clinical usability point-of-view, we propose to divide this calibration problem into two steps: i) in initial calibration of the EM sensor to the phantom design using an EM tracked needle to trace out grooves in the phantom surface and ii) segmentation from X-ray images and 3D reconstruction of beads embedded in the phantom in a known geometric pattern. Combining these two steps yields and X-ray-to-EM calibration accuracy of less than 1 mm when overlaying an EM tracked needle on X-ray images.

  4. Matrix Algebra for GPU and Multicore Architectures (MAGMA) for Large Petascale Systems

    SciTech Connect

    Dongarra, Jack J.; Tomov, Stanimire

    2014-03-24

    The goal of the MAGMA project is to create a new generation of linear algebra libraries that achieve the fastest possible time to an accurate solution on hybrid Multicore+GPU-based systems, using all the processing power that future high-end systems can make available within given energy constraints. Our efforts at the University of Tennessee achieved the goals set in all of the five areas identified in the proposal: 1. Communication optimal algorithms; 2. Autotuning for GPU and hybrid processors; 3. Scheduling and memory management techniques for heterogeneity and scale; 4. Fault tolerance and robustness for large scale systems; 5. Building energy efficiency into software foundations. The University of Tennessee’s main contributions, as proposed, were the research and software development of new algorithms for hybrid multi/many-core CPUs and GPUs, as related to two-sided factorizations and complete eigenproblem solvers, hybrid BLAS, and energy efficiency for dense, as well as sparse, operations. Furthermore, as proposed, we investigated and experimented with various techniques targeting the five main areas outlined.

  5. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior.

    PubMed

    Kiupel, M; Webster, J D; Bailey, K L; Best, S; DeLay, J; Detrisac, C J; Fitzgerald, S D; Gamble, D; Ginn, P E; Goldschmidt, M H; Hendrick, M J; Howerth, E W; Janovitz, E B; Langohr, I; Lenz, S D; Lipscomb, T P; Miller, M A; Misdorp, W; Moroff, S; Mullaney, T P; Neyens, I; O'Toole, D; Ramos-Vara, J; Scase, T J; Schulman, F Y; Sledge, D; Smedley, R C; Smith, K; W Snyder, P; Southorn, E; Stedman, N L; Steficek, B A; Stromberg, P C; Valli, V E; Weisbrode, S E; Yager, J; Heller, J; Miller, R

    2011-01-01

    Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists and institutional modifications make the prognostic value of histologic grading highly questionable. To evaluate the consistency of microscopic grading among veterinary pathologists and the prognostic significance of the Patnaik grading system, 95 cutaneous MCTs from 95 dogs were graded in a blinded study by 28 veterinary pathologists from 16 institutions. Concordance among veterinary pathologists was 75% for the diagnosis of grade 3 MCTs and less than 64% for the diagnosis of grade 1 and 2 MCTs. To improve concordance among pathologists and to provide better prognostic significance, a 2-tier histologic grading system was devised. The diagnosis of high-grade MCTs is based on the presence of any one of the following criteria: at least 7 mitotic figures in 10 high-power fields (hpf); at least 3 multinucleated (3 or more nuclei) cells in 10 hpf; at least 3 bizarre nuclei in 10 hpf; karyomegaly (ie, nuclear diameters of at least 10% of neoplastic cells vary by at least two-fold). Fields with the highest mitotic activity or with the highest degree of anisokaryosis were selected to assess the different parameters. According to the novel grading system, high-grade MCTs were significantly associated with shorter time to metastasis or new tumor development, and with shorter survival time. The median survival time was less than 4 months for high-grade MCTs but more than 2 years for low-grade MCTs.

  6. A Tumor-specific MicroRNA Recognition System Facilitates the Accurate Targeting to Tumor Cells by Magnetic Nanoparticles

    PubMed Central

    Yu, Yingting; Yao, Yi; Yan, Hao; Wang, Rui; Zhang, Zhenming; Sun, Xiaodan; Zhao, Lingyun; Ao, Xiang; Xie, Zhen; Wu, Qiong

    2016-01-01

    Targeted therapy for cancer is a research area of great interest, and magnetic nanoparticles (MNPs) show great potential as targeted carriers for therapeutics. One important class of cancer biomarkers is microRNAs (miRNAs), which play a significant role in tumor initiation and progression. In this study, a cascade recognition system containing multiple plasmids, including a Tet activator, a lacI repressor gene driven by the TetOn promoter, and a reporter gene repressed by the lacI repressor and influenced by multiple endogenous miRNAs, was used to recognize cells that display miRNA signals that are characteristic of cancer. For this purpose, three types of signal miRNAs with high proliferation and metastasis abilities were chosen (miR-21, miR-145, and miR-9). The response of this system to the human breast cancer MCF-7 cell line was 3.2-fold higher than that to the human breast epithelial HBL100 cell line and almost 7.5-fold higher than that to human embryonic kidney HEK293T cells. In combination with polyethyleneimine-modified MNPs, this recognition system targeted the tumor location in situ in an animal model, and an ~42% repression of tumor growth was achieved. Our study provides a new combination of magnetic nanocarrier and gene therapy based on miRNAs that are active in vivo, which has potential for use in future cancer therapies. PMID:27138178

  7. A matrix lower bound

    SciTech Connect

    Grcar, Joseph F.

    2002-02-04

    A matrix lower bound is defined that generalizes ideas apparently due to S. Banach and J. von Neumann. The matrix lower bound has a natural interpretation in functional analysis, and it satisfies many of the properties that von Neumann stated for it in a restricted case. Applications for the matrix lower bound are demonstrated in several areas. In linear algebra, the matrix lower bound of a full rank matrix equals the distance to the set of rank-deficient matrices. In numerical analysis, the ratio of the matrix norm to the matrix lower bound is a condition number for all consistent systems of linear equations. In optimization theory, the matrix lower bound suggests an identity for a class of min-max problems. In real analysis, a recursive construction that depends on the matrix lower bound shows that the level sets of continuously differential functions lie asymptotically near those of their tangents.

  8. An efficient and accurate approximation to time-dependent density functional theory for systems of weakly coupled monomers

    NASA Astrophysics Data System (ADS)

    Liu, Jie; Herbert, John M.

    2015-07-01

    A novel formulation of time-dependent density functional theory (TDDFT) is derived, based on non-orthogonal, absolutely-localized molecular orbitals (ALMOs). We call this approach TDDFT(MI), in reference to ALMO-based methods for describing molecular interactions (MI) that have been developed for ground-state applications. TDDFT(MI) is intended for efficient excited-state calculations in systems composed of multiple, weakly interacting chromophores. The efficiency is based upon (1) a local excitation approximation; (2) monomer-based, singly-excited basis states; (3) an efficient localization procedure; and (4) a one-step Davidson method to solve the TDDFT(MI) working equation. We apply this methodology to study molecular dimers, water clusters, solvated chromophores, and aggregates of naphthalene diimide that form the building blocks of self-assembling organic nanotubes. Absolute errors of 0.1-0.3 eV with respect to supersystem methods are achievable for these systems, especially for cases involving an excited chromophore that is weakly coupled to several explicit solvent molecules. Excited-state calculations in an aggregate of nine naphthalene diimide monomers are ˜40 times faster than traditional TDDFT calculations.

  9. The extracellular matrix of Volvox: a comparative study and proposed system of nomenclature.

    PubMed

    Kirk, D L; Birchem, R; King, N

    1986-02-01

    The structure of the extracellular matrix (ECM) of representatives of all four sections of the genus Volvox was examined by a combination of light- and electron-microscopic methods. On the basis of these observations, plus published descriptions of aspects of ECM organization in other members of the order Volvocales, a system of nomenclature is proposed, to facilitate discussion of comparative morphology and phylogeny of the ECM in the order. In this system the ECM is divided into four main zones: the flagellar zone (FZ), which consists of attachments to and specializations of the ECM around the flagella; the boundary zone (BZ), which consists of portions of the ECM that (except in periflagellar regions) are continuous over the surface of the organism and are not structurally continuous with deeper layers; the cellular zone (CZ), which consists of specializations, other than those of the FZ, around individual cells; and the deep zone (DZ), which consists of components that fill the central region of the organism, internal to CZ. An empirically based set of hierarchical subdivisions of these zones is then proposed that permits specific identification of most morphologically distinct ECM components. The fact that not all zones and subzones are present in all members of the order means that this system permits identification of those ECM structures that have been gained or lost during Volvocalean evolution. Species-specific differences in the structure of virtually all aspects of the ECM were seen among the Volvox species examined in this study. However, the fact that such differences cannot always be used as diagnostic characters for the four divisions of the genus was demonstrated by the observation that in certain ECM features two members of the same division (V. carteri f. nagariensis and V. carteri f. weismannia) differ markedly in structure from one another, with one member of the pair resembling a member of another division. Thus many details of ECM

  10. Finite Element Modelling of a Field-Sensed Magnetic Suspended System for Accurate Proximity Measurement Based on a Sensor Fusion Algorithm with Unscented Kalman Filter.

    PubMed

    Chowdhury, Amor; Sarjaš, Andrej

    2016-01-01

    The presented paper describes accurate distance measurement for a field-sensed magnetic suspension system. The proximity measurement is based on a Hall effect sensor. The proximity sensor is installed directly on the lower surface of the electro-magnet, which means that it is very sensitive to external magnetic influences and disturbances. External disturbances interfere with the information signal and reduce the usability and reliability of the proximity measurements and, consequently, the whole application operation. A sensor fusion algorithm is deployed for the aforementioned reasons. The sensor fusion algorithm is based on the Unscented Kalman Filter, where a nonlinear dynamic model was derived with the Finite Element Modelling approach. The advantage of such modelling is a more accurate dynamic model parameter estimation, especially in the case when the real structure, materials and dimensions of the real-time application are known. The novelty of the paper is the design of a compact electro-magnetic actuator with a built-in low cost proximity sensor for accurate proximity measurement of the magnetic object. The paper successively presents a modelling procedure with the finite element method, design and parameter settings of a sensor fusion algorithm with Unscented Kalman Filter and, finally, the implementation procedure and results of real-time operation. PMID:27649197

  11. Finite Element Modelling of a Field-Sensed Magnetic Suspended System for Accurate Proximity Measurement Based on a Sensor Fusion Algorithm with Unscented Kalman Filter

    PubMed Central

    Chowdhury, Amor; Sarjaš, Andrej

    2016-01-01

    The presented paper describes accurate distance measurement for a field-sensed magnetic suspension system. The proximity measurement is based on a Hall effect sensor. The proximity sensor is installed directly on the lower surface of the electro-magnet, which means that it is very sensitive to external magnetic influences and disturbances. External disturbances interfere with the information signal and reduce the usability and reliability of the proximity measurements and, consequently, the whole application operation. A sensor fusion algorithm is deployed for the aforementioned reasons. The sensor fusion algorithm is based on the Unscented Kalman Filter, where a nonlinear dynamic model was derived with the Finite Element Modelling approach. The advantage of such modelling is a more accurate dynamic model parameter estimation, especially in the case when the real structure, materials and dimensions of the real-time application are known. The novelty of the paper is the design of a compact electro-magnetic actuator with a built-in low cost proximity sensor for accurate proximity measurement of the magnetic object. The paper successively presents a modelling procedure with the finite element method, design and parameter settings of a sensor fusion algorithm with Unscented Kalman Filter and, finally, the implementation procedure and results of real-time operation. PMID:27649197

  12. Finite Element Modelling of a Field-Sensed Magnetic Suspended System for Accurate Proximity Measurement Based on a Sensor Fusion Algorithm with Unscented Kalman Filter.

    PubMed

    Chowdhury, Amor; Sarjaš, Andrej

    2016-09-15

    The presented paper describes accurate distance measurement for a field-sensed magnetic suspension system. The proximity measurement is based on a Hall effect sensor. The proximity sensor is installed directly on the lower surface of the electro-magnet, which means that it is very sensitive to external magnetic influences and disturbances. External disturbances interfere with the information signal and reduce the usability and reliability of the proximity measurements and, consequently, the whole application operation. A sensor fusion algorithm is deployed for the aforementioned reasons. The sensor fusion algorithm is based on the Unscented Kalman Filter, where a nonlinear dynamic model was derived with the Finite Element Modelling approach. The advantage of such modelling is a more accurate dynamic model parameter estimation, especially in the case when the real structure, materials and dimensions of the real-time application are known. The novelty of the paper is the design of a compact electro-magnetic actuator with a built-in low cost proximity sensor for accurate proximity measurement of the magnetic object. The paper successively presents a modelling procedure with the finite element method, design and parameter settings of a sensor fusion algorithm with Unscented Kalman Filter and, finally, the implementation procedure and results of real-time operation.

  13. Methods of use and presentation of the accurate astrometric data based on the modern terrestrial and celestial reference systems

    NASA Astrophysics Data System (ADS)

    Sekowski, M.; Krynski, J.

    2012-12-01

    The increasing precision of the modern astrometric data as well as changes from the introduction of a new paradigm for the relations of terrestrial and celestial systems, forces the changes in methods of the usage and presentation of the data. The paper presents the efforts undertaken to satisfy these needs in the 'Rocznik Astronomiczny'. Among the issues under consideration are: 1) identification and analysis of the sources of problems with interpolation of the high accuracy data; 2) reviewing the used interpolation methods; 3) development of the new methods of presenting of the high accuracy data, allowing their proper interpolation; 4) research on the need and the possibility to redefine the Besselian Numbers algorithm in calculations of the apparent places, to the form in which it could be used in the new paradigm (CIP/CIO).

  14. Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems

    SciTech Connect

    Samudrala, Ram; Heffron, Fred; McDermott, Jason E.

    2009-04-24

    The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates, effector proteins, are not. We have used a machine learning approach to identify new secreted effectors. The method integrates evolutionary measures, such as the pattern of homologs in a range of other organisms, and sequence-based features, such as G+C content, amino acid composition and the N-terminal 30 residues of the protein sequence. The method was trained on known effectors from Salmonella typhimurium and validated on a corresponding set of effectors from Pseudomonas syringae, after eliminating effectors with detectable sequence similarity. The method was able to identify all of the known effectors in P. syringae with a specificity of 84% and sensitivity of 82%. The reciprocal validation, training on P. syringae and validating on S. typhimurium, gave similar results with a specificity of 86% when the sensitivity level was 87%. These results show that type III effectors in disparate organisms share common features. We found that maximal performance is attained by including an N-terminal sequence of only 30 residues, which agrees with previous studies indicating that this region contains the secretion signal. We then used the method to define the most important residues in this putative secretion signal. Finally, we present novel predictions of secreted effectors in S. typhimurium, some of which have been experimentally validated, and apply the method to predict secreted effectors in the genetically intractable human pathogen Chlamydia trachomatis. This approach is a novel and effective way to identify secreted effectors in a broad range of pathogenic bacteria for further experimental characterization and provides insight into the nature of the type III secretion signal.

  15. In vitro and in vivo evaluation of a matrix-in-cylinder system for sustained drug delivery.

    PubMed

    Mehuys, E; Vervaet, C; Gielen, I; Van Bree, H; Remon, J P

    2004-04-28

    A matrix-in-cylinder system for sustained drug delivery, consisting of a hot-melt extruded ethylcellulose (EC) pipe surrounding a drug containing HPMC-Gelucire 44/14 core, was evaluated in vitro and in vivo. In an aqueous medium, the HPMC-Gelucire core forms a gel plug, which releases the drug-through the open ends of the EC pipe--by means of erosion. The influence of hydrodynamic and mechanical stress and the effect of different 'physiologically relevant' dissolution media on the in vitro drug release were investigated. From these in vitro dissolution tests, it was concluded that the EC pipe has a protective effect on the drug containing HPMC-Gelucire core. It largely protects the core against hydrodynamics and mechanical stress. Furthermore, drug release from the matrix-in-cylinder system was only slightly affected by the composition of the dissolution medium. A randomised crossover in vivo study in dogs revealed that the matrix-in-cylinder system containing propranolol hydrochloride has an ideal sustained release profile with constant plasma levels maintained over 24 h. Moreover, administration of the matrix-in-cylinder system resulted in a 4-fold increase in propranolol bioavailability when compared with a commercial sustained release formulation (Inderal).

  16. Solving rational matrix equations in the state space with applications to computer-aided control-system design

    NASA Technical Reports Server (NTRS)

    Packard, A. K.; Sastry, S. S.

    1986-01-01

    A method of solving a class of linear matrix equations over various rings is proposed, using results from linear geometric control theory. An algorithm, successfully implemented, is presented, along with non-trivial numerical examples. Applications of the method to the algebraic control system design methodology are discussed.

  17. The effect of an autologous cellular gel-matrix integrated implant system on wound healing

    PubMed Central

    2010-01-01

    Background This manuscript reports the production and preclinical studies to examine the tolerance and efficacy of an autologous cellular gel-matrix integrated implant system (IIS) aimed to treat full-thickness skin lesions. Methods The best concentration of fibrinogen and thrombin was experimentally determined by employing 28 formula ratios of thrombin and fibrinogen and checking clot formation and apparent stability. IIS was formed by integrating skin cells by means of the in situ gelification of fibrin into a porous crosslinked scaffold composed of chitosan, gelatin and hyaluronic acid. The in vitro cell proliferation within the IIS was examined by the MTT assay and PCNA expression. An experimental rabbit model consisting of six circular lesions was utilized to test each of the components of the IIS. Then, the IIS was utilized in an animal model to cover a 35% body surface full thickness lesion. Results The preclinical assays in rabbits demonstrated that the IIS was well tolerated and also that IIS-treated rabbit with lesions of 35% of their body surface, exhibited a better survival rate (p = 0,06). Conclusion IIS should be further studied as a new wound dressing which shows promising properties, being the most remarkable its good biological tolerance and cell growth promotion properties. PMID:20565787

  18. Singular-potential random-matrix model arising in mean-field glassy systems

    NASA Astrophysics Data System (ADS)

    Akemann, Gernot; Villamaina, Dario; Vivo, Pierpaolo

    2014-06-01

    We consider an invariant random matrix ensemble where the standard Gaussian potential is distorted by an additional single pole of arbitrary fixed order. Potentials with first- and second-order poles have been considered previously and found applications in quantum chaos and number theory. Here we present an application to mean-field glassy systems. We derive and solve the loop equation in the planar limit for the corresponding class of potentials. We find that the resulting mean or macroscopic spectral density is generally supported on two disconnected intervals lying on the two sides of the repulsive pole, whose edge points can be completely determined imposing the additional constraint of traceless matrices on average. For an unbounded potential with an attractive pole, we also find a possible one-cut solution for certain values of the couplings, which is ruled out when the traceless condition is imposed. Motivated by the calculation of the distribution of the spin-glass susceptibility in the Sherrington-Kirkpatrick spin-glass model, we consider in detail a second-order pole for a zero-trace model and provide the most explicit solution in this case. In the limit of a vanishing pole, we recover the standard semicircle. Working in the planar limit, our results apply to matrices with orthogonal, unitary, and symplectic invariance. Numerical simulations and an independent analytical Coulomb fluid calculation for symmetric potentials provide an excellent confirmation of our results.

  19. Stabilization of pH in solid-matrix hydroponic systems

    NASA Technical Reports Server (NTRS)

    Frick, J.; Mitchell, C. A.

    1993-01-01

    2-[N-morpholino]ethanesulfonic acid (MES) buffer or Amberlite DP-1 (cation-exchange resin beads) were used to stabilize substrate pH of passive-wicking, solid-matrix hydroponic systems in which small canopies of Brassica napus L. (CrGC 5-2, genome : ACaacc) were grown to maturity. Two concentrations of MES (5 or 10 mM) were included in Hoagland 1 nutrient solution. Alternatively, resin beads were incorporated into the 2 vermiculite : 1 perlite (v/v) growth medium at 6% or 12% of total substrate volume. Both strategies stabilized pH without toxic side effects on plants. Average seed yield rates for all four pH stabilization treatments (13.3 to 16.9 g m-2 day-1) were about double that of the control (8.2 g m-2 day-1), for which there was no attempt to buffer substrate pH. Both the highest canopy seed yield rate (16.9 g m-2 day-1) and the highest shoot harvest index (19.5%) occurred with the 6% resin bead treatment, even though the 10 mM MES and 12% bead treatments maintained pH within the narrowest limits. The pH stabilization methods tested did not significantly affect seed oil and protein contents.

  20. System and method for the adaptive mapping of matrix data to sets of polygons

    NASA Technical Reports Server (NTRS)

    Burdon, David (Inventor)

    2003-01-01

    A system and method for converting bitmapped data, for example, weather data or thermal imaging data, to polygons is disclosed. The conversion of the data into polygons creates smaller data files. The invention is adaptive in that it allows for a variable degree of fidelity of the polygons. Matrix data is obtained. A color value is obtained. The color value is a variable used in the creation of the polygons. A list of cells to check is determined based on the color value. The list of cells to check is examined in order to determine a boundary list. The boundary list is then examined to determine vertices. The determination of the vertices is based on a prescribed maximum distance. When drawn, the ordered list of vertices create polygons which depict the cell data. The data files which include the vertices for the polygons are much smaller than the corresponding cell data files. The fidelity of the polygon representation can be adjusted by repeating the logic with varying fidelity values to achieve a given maximum file size or a maximum number of vertices per polygon.

  1. Parametric study of the cyclic behaviour of a hygroscopic matrix in a desiccant airflow system

    NASA Astrophysics Data System (ADS)

    Ruivo, C. R.; Costa, J. J.; Figueiredo, A. R.

    2011-09-01

    The study of the transport phenomena in desiccant airflow systems has been addressed in numerous research works, some of them concerning combined processes of cooling, dehumidification and energy recovery. In this paper a detailed numerical model is used to simulate the behaviour of a parallel-plate channel, cyclically exposed to two airflows with different inlet conditions, the plate being composed by a substrate and a desiccant porous layer. The modelled channel is considered to be representative of a real channel of a hygroscopic matrix that is operating at steady state regime, like it occurs in desiccant or enthalpy rotors. The numerical results are treated in order to represent the global behaviour of the hygroscopic rotor under steady state conditions. Results of a parametric study are presented as maps of isovalues of the heat and mass transfer rates and of the outlet states of both airflows, considering channels of distinct wall thickness, of different thickness of the desiccant and the subtract layers, together with wide ranges of the rotation speed and of the wheel partition. The mapped results presented provide an overview of the operation characteristics of hygroscopic rotors, allowing a quick determination of the optimum range of values for relevant parameters, such as the rotation speed and the wheel partition. The model is thus an interesting tool for design and manufacture purposes of enthalpy and desiccant wheels.

  2. Chondroitin sulphate proteoglycans: extracellular matrix proteins that regulate immunity of the central nervous system.

    PubMed

    Haylock-Jacobs, Sarah; Keough, Michael B; Lau, Lorraine; Yong, V Wee

    2011-10-01

    The extracellular matrix (ECM) is a complex network of scaffolding molecules that also plays an important role in cell signalling, migration and tissue structure. In the central nervous system (CNS), the ECM is integral to the efficient development/guidance and survival of neurons and axons. However, changes in distribution of the ECM in the CNS may significantly enhance pathology in CNS disease or following injury. One group of ECM proteins that is important for CNS homeostasis is the chondroitin sulphate proteoglycans (CSPGs). Up-regulation of these molecules has been demonstrated to be both desirable and detrimental following CNS injury. Taking cues from arthritis, where there is a strong anti-CSPG immune response, there is evidence that suggests that CSPGs may influence immunity during CNS pathological conditions. This review focuses on the role of CSPGs in CNS pathologies as well as in immunity, both from a viewpoint of how they may inhibit repair and exacerbate damage in the CNS, and how they are involved in activation and function of peripheral immune cells, particularly in multiple sclerosis. Lastly, we address how CSPGs may be manipulated to improve disease outcomes.

  3. Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes

    PubMed Central

    Huang, Hai; Kornberg, Thomas B

    2016-01-01

    Drosophila dorsal air sac development depends on Decapentaplegic (Dpp) and Fibroblast growth factor (FGF) proteins produced by the wing imaginal disc and transported by cytonemes to the air sac primordium (ASP). Dpp and FGF signaling in the ASP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp- nor FGF-receiving cytonemes extended over mutant disc cells that lacked them. ASP cytonemes normally navigate through extracellular matrix (ECM) composed of collagen, laminin, Dally and Dally-like (Dlp) proteins that are stratified in layers over the disc cells. However, ECM over PCP mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally). These findings suggest that cytonemes interact directly and specifically with proteins in the stratified ECM. DOI: http://dx.doi.org/10.7554/eLife.18979.001 PMID:27591355

  4. Stabilization of pH in solid-matrix hydroponic systems.

    PubMed

    Frick, J; Mitchell, C A

    1993-10-01

    2-[N-morpholino]ethanesulfonic acid (MES) buffer or Amberlite DP-1 (cation-exchange resin beads) were used to stabilize substrate pH of passive-wicking, solid-matrix hydroponic systems in which small canopies of Brassica napus L. (CrGC 5-2, genome : ACaacc) were grown to maturity. Two concentrations of MES (5 or 10 mM) were included in Hoagland 1 nutrient solution. Alternatively, resin beads were incorporated into the 2 vermiculite : 1 perlite (v/v) growth medium at 6% or 12% of total substrate volume. Both strategies stabilized pH without toxic side effects on plants. Average seed yield rates for all four pH stabilization treatments (13.3 to 16.9 g m-2 day-1) were about double that of the control (8.2 g m-2 day-1), for which there was no attempt to buffer substrate pH. Both the highest canopy seed yield rate (16.9 g m-2 day-1) and the highest shoot harvest index (19.5%) occurred with the 6% resin bead treatment, even though the 10 mM MES and 12% bead treatments maintained pH within the narrowest limits. The pH stabilization methods tested did not significantly affect seed oil and protein contents. PMID:11537992

  5. Singular-potential random-matrix model arising in mean-field glassy systems.

    PubMed

    Akemann, Gernot; Villamaina, Dario; Vivo, Pierpaolo

    2014-06-01

    We consider an invariant random matrix ensemble where the standard Gaussian potential is distorted by an additional single pole of arbitrary fixed order. Potentials with first- and second-order poles have been considered previously and found applications in quantum chaos and number theory. Here we present an application to mean-field glassy systems. We derive and solve the loop equation in the planar limit for the corresponding class of potentials. We find that the resulting mean or macroscopic spectral density is generally supported on two disconnected intervals lying on the two sides of the repulsive pole, whose edge points can be completely determined imposing the additional constraint of traceless matrices on average. For an unbounded potential with an attractive pole, we also find a possible one-cut solution for certain values of the couplings, which is ruled out when the traceless condition is imposed. Motivated by the calculation of the distribution of the spin-glass susceptibility in the Sherrington-Kirkpatrick spin-glass model, we consider in detail a second-order pole for a zero-trace model and provide the most explicit solution in this case. In the limit of a vanishing pole, we recover the standard semicircle. Working in the planar limit, our results apply to matrices with orthogonal, unitary, and symplectic invariance. Numerical simulations and an independent analytical Coulomb fluid calculation for symmetric potentials provide an excellent confirmation of our results.

  6. Blade system design studies volume II : preliminary blade designs and recommended test matrix.

    SciTech Connect

    Griffin, Dayton A.

    2004-06-01

    As part of the U.S. Department of Energy's Wind Partnerships for Advanced Component Technologies (WindPACT) program, Global Energy Concepts, LLC is performing a Blade System Design Study (BSDS) concerning innovations in materials, processes and structural configurations for application to wind turbine blades in the multi-megawatt range. The BSDS Volume I project report addresses issues and constraints identified to scaling conventional blade designs to the megawatt size range, and evaluated candidate materials, manufacturing and design innovations for overcoming and improving large blade economics. The current report (Volume II), presents additional discussion of materials and manufacturing issues for large blades, including a summary of current trends in commercial blade manufacturing. Specifications are then developed to guide the preliminary design of MW-scale blades. Using preliminary design calculations for a 3.0 MW blade, parametric analyses are performed to quantify the potential benefits in stiffness and decreased gravity loading by replacement of a baseline fiberglass spar with carbon-fiberglass hybrid material. Complete preliminary designs are then presented for 3.0 MW and 5.0 MW blades that incorporate fiberglass-to-carbon transitions at mid-span. Based on analysis of these designs, technical issues are identified and discussed. Finally, recommendations are made for composites testing under Part I1 of the BSDS, and the initial planned test matrix for that program is presented.

  7. Multicenter Evaluation of the Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Gram-Positive Aerobic Bacteria

    PubMed Central

    Burnham, Carey-Ann D.; Bythrow, Maureen; Garner, Omai B.; Ginocchio, Christine C.; Jennemann, Rebecca; Lewinski, Michael A.; Manji, Ryhana; Mochon, A. Brian; Procop, Gary W.; Richter, Sandra S.; Sercia, Linda; Westblade, Lars F.; Ferraro, Mary Jane; Branda, John A.

    2013-01-01

    Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF) is gaining momentum as a tool for bacterial identification in the clinical microbiology laboratory. Compared with conventional methods, this technology can more readily and conveniently identify a wide range of organisms. Here, we report the findings from a multicenter study to evaluate the Vitek MS v2.0 system (bioMérieux, Inc.) for the identification of aerobic Gram-positive bacteria. A total of 1,146 unique isolates, representing 13 genera and 42 species, were analyzed, and results were compared to those obtained by nucleic acid sequence-based identification as the reference method. For 1,063 of 1,146 isolates (92.8%), the Vitek MS provided a single identification that was accurate to the species level. For an additional 31 isolates (2.7%), multiple possible identifications were provided, all correct at the genus level. Mixed-genus or single-choice incorrect identifications were provided for 18 isolates (1.6%). Although no identification was obtained for 33 isolates (2.9%), there was no specific bacterial species for which the Vitek MS consistently failed to provide identification. In a subset of 463 isolates representing commonly encountered important pathogens, 95% were accurately identified to the species level and there were no misidentifications. Also, in all but one instance, the Vitek MS correctly differentiated Streptococcus pneumoniae from other viridans group streptococci. The findings demonstrate that the Vitek MS system is highly accurate for the identification of Gram-positive aerobic bacteria in the clinical laboratory setting. PMID:23658261

  8. Magnetic Paleofield of Avanhandava H4 Chondrite's Matrix and Chondrules - Implications on Magnetic Fields in Early Solar System.

    NASA Astrophysics Data System (ADS)

    Kohout, T.; Pesonen, L. J.

    2005-12-01

    The Avanhandava (H4) fall occurred in 1952 in Brazil. A total of 9.33 kg had been preserved after the meteorite brake up during the impact [1]. The meteorite contains large (0.1 - 2.0 mm) chon-drules that have clearly delineated boundaries with matrix. This characteristic allows us to pick up oriented individual chondrules and study their magnetic properties. The chondrules of the Avanhandava meteorite show a low and randomly oriented NRM (10-2 - 10-1 mAm2/kg). In contrast the matrix is strongly (100 - 101 mAm2/kg) and uniformly magnet-ized [2]. Various methods for paleofield determination have been applied on matrix and individual chondrules in order to determine possi-ble magnetizing processes and paleofields in early solar systems.. The laboratory experiments reveal approximate paleofields for matrix similar to present geomagnetic field. The paleofield de-termined for chondrules is approximately one order of magnitude lower comparing to values obtained for matrix. That suggests that chondrules are not magnetically contaminated by geomagnetic or artificial fields and they acquired their NRM prior their aggregation to Avanhandava parent body (random NRM directions). The matrix shows remarkable traces of terres-trial weathering and is uniformly magnetized. The paleofield re-sult for matrix indicates possible remagnetization caused by ter-restrial weathering. The terrestrial weathering of ordinary chon-drites is observed even on falls stored in museums and can sig-nificantly influence meteorite magnetic records [3, 4]. References: [1] Paar W. et al. 1976. Revista Brasileira de Geo-ciencias 6: 201-210. [2] Kohout T. and Pesonen L. J. 2005. 68th Annual Meteoritical Society Meeting: 5202. [3] Kohout T. et al. 2004. Physics and Chemistry of the Earth 29: 885-897. [4] Lee M. R. and Bland P. A. 2004. Geochimica et Cosmochimica Acta 68: 893-916.

  9. Cholesky-decomposed density MP2 with density fitting: Accurate MP2 and double-hybrid DFT energies for large systems

    SciTech Connect

    Maurer, Simon A.; Clin, Lucien; Ochsenfeld, Christian

    2014-06-14

    Our recently developed QQR-type integral screening is introduced in our Cholesky-decomposed pseudo-densities Møller-Plesset perturbation theory of second order (CDD-MP2) method. We use the resolution-of-the-identity (RI) approximation in combination with efficient integral transformations employing sparse matrix multiplications. The RI-CDD-MP2 method shows an asymptotic cubic scaling behavior with system size and a small prefactor that results in an early crossover to conventional methods for both small and large basis sets. We also explore the use of local fitting approximations which allow to further reduce the scaling behavior for very large systems. The reliability of our method is demonstrated on test sets for interaction and reaction energies of medium sized systems and on a diverse selection from our own benchmark set for total energies of larger systems. Timings on DNA systems show that fast calculations for systems with more than 500 atoms are feasible using a single processor core. Parallelization extends the range of accessible system sizes on one computing node with multiple cores to more than 1000 atoms in a double-zeta basis and more than 500 atoms in a triple-zeta basis.

  10. Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction

    SciTech Connect

    Aguiar, Pablo; Pino, Francisco; Silva-Rodríguez, Jesús; Pavía, Javier; Ros, Doménec; Ruibal, Álvaro; and others

    2014-03-15

    Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the

  11. Ranking of small scale proposals for water system repair using the Rapid Impact Assessment Matrix (RIAM)

    SciTech Connect

    Shakib-Manesh, T.E.; Hirvonen, K.O.; Jalava, K.J.; Ålander, T.; Kuitunen, M.T.

    2014-11-15

    Environmental impacts of small scale projects are often assessed poorly, or not assessed at all. This paper examines the usability of the Rapid Impact Assessment Matrix (RIAM) as a tool to prioritize project proposals for small scale water restoration projects in relation to proposals' potential to improve the environment. The RIAM scoring system was used to assess and rank the proposals based on their environmental impacts, the costs of the projects to repair the harmful impacts, and the size of human population living around the sites. A four-member assessment group (The expert panel) gave the RIAM-scores to the proposals. The assumed impacts of the studied projects at the Eastern Finland water systems were divided into the ecological and social impacts. The more detailed assessment categories of the ecological impacts in this study were impacts on landscape, natural state, and limnology. The social impact categories were impacts to recreational use of the area, fishing, industry, population, and economy. These impacts were scored according to their geographical and social significance, their magnitude of change, their character, permanence, reversibility, and cumulativeness. The RIAM method proved to be an appropriate and recommendable method for the small-scale assessment and prioritizing of project proposals. If the assessments are well documented, the RIAM can be a method for easy assessing and comparison of the various kinds of projects. In the studied project proposals there were no big surprises in the results: the best ranks were received by the projects, which were assumed to return watersheds toward their original state.

  12. The Density Matrix Renormalization Group for Strongly Correlated Electron Systems: A Generic Implementation

    SciTech Connect

    Alvarez, Gonzalo

    2009-01-01

    The purpose of this paper is (1) to present a generic and fully functional implementation of the density-matrix renormalization group (DMRG) algorithm, and (2) to describe how to write additional strongly-correlated electron models and geometries by using templated classes. Besides considering general models and geometries, the code implements Hamiltonian symmetries in a generic way and parallelization over symmetry-related matrix blocks.

  13. Determination of optimal collimation parameters for a rotating slat collimator system: a system matrix method using ML-EM

    NASA Astrophysics Data System (ADS)

    Boisson, F.; Bekaert, V.; Brasse, D.

    2016-03-01

    Nowadays, Single Photon imaging has become an essential part of molecular imaging and nuclear medicine. Whether to establish a diagnosis or in the therapeutic monitoring, this modality presents performance that continues to improve. For over 50 years, several collimators have been proposed. Mainly governed by collimation parameters, the resolution-sensitivity trade-off is the factor determining the collimator the most suitable for an intended study. One alternative to the common approaches is the rotating slat collimator (RSC). In the present study, we are aiming at developing a preclinical system equipped with a RSC dedicated to mice and rats imaging, which requires both high sensitivity and spatial resolution. We investigated the resolution-sensitivity trade-offs obtained by varying different collimation parameters: (i) the slats height (H), and (ii) the gap between two consecutive slats (g), considering different intrinsic spatial resolutions. One system matrix was generated for each set of collimation parameters (H,g). Spatial resolutions, Signal-to-Noise Ratio (SNR) and sensitivity obtained for all the set of collimation parameters (H,g) were measured in the 2D projections reconstructed with ML-EM. According to our results, 20 mm high slats and a 1 mm gap were chosen as a good RSC candidate for a preclinical detection module. This collimator will ensure a sensitivity greater than 0.2% and a system spatial resolution below 1 mm, considering an intrinsic spatial resolution below 0.8 mm.

  14. Determination of optimal collimation parameters for a rotating slat collimator system: a system matrix method using ML-EM.

    PubMed

    Boisson, F; Bekaert, V; Brasse, D

    2016-03-21

    Nowadays, Single Photon imaging has become an essential part of molecular imaging and nuclear medicine. Whether to establish a diagnosis or in the therapeutic monitoring, this modality presents performance that continues to improve. For over 50 years, several collimators have been proposed. Mainly governed by collimation parameters, the resolution-sensitivity trade-off is the factor determining the collimator the most suitable for an intended study. One alternative to the common approaches is the rotating slat collimator (RSC). In the present study, we are aiming at developing a preclinical system equipped with a RSC dedicated to mice and rats imaging, which requires both high sensitivity and spatial resolution. We investigated the resolution-sensitivity trade-offs obtained by varying different collimation parameters: (i) the slats height (H), and (ii) the gap between two consecutive slats (g), considering different intrinsic spatial resolutions. One system matrix was generated for each set of collimation parameters (H,g). Spatial resolutions, Signal-to-Noise Ratio (SNR) and sensitivity obtained for all the set of collimation parameters (H,g) were measured in the 2D projections reconstructed with ML-EM. According to our results, 20 mm high slats and a 1 mm gap were chosen as a good RSC candidate for a preclinical detection module. This collimator will ensure a sensitivity greater than 0.2% and a system spatial resolution below 1 mm, considering an intrinsic spatial resolution below 0.8 mm. PMID:26930449

  15. Stimulant-induced adaptations in neostriatal matrix and striosome systems: transiting from instrumental responding to habitual behavior in drug addiction.

    PubMed

    Canales, Juan J

    2005-03-01

    Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug. Such alterations, which correlate with persistent patterns of repetitive behavior, associate with distinct compartmental changes in the neostriatum. Striatal matrix system neurons undergo "silencing" following repeated drug challenges, allowing striosome system neurons to exhibit preferential activation. Matrix neurons are innervated by sensory and motor areas of neocortex and are activated in the course of on-going, adaptive behavior. Inactivation of matrix neurons by chronic stimulant exposure may therefore constrain sensorimotor and cognitive processing. In turn, the striosomes are anatomically connected through re-entrant loops with limbic prefrontal and allocortical structures, such as anterior cingulate cortex, orbital frontal cortex, and basolateral amygdala, all of which play a part in stimulant-induced reinforcement and relapse to drug-taking. Moreover, functional evidence links striosome system neurons, which are responsible for providing inhibitory regulatory feedback to midbrain dopamine neurons, with reinforcement-based processes. In considering such evidence, we postulate that recurrent matrix inactivation and recruitment of striosome-based pathways by chronic stimulant exposure represent neural end-points of the transit from action-outcome associative behavior to conditioned habitual responding. Within this theoretical framework, habitual behavior can be elicited by both interoceptive cues and exteroceptive conditioned stimuli to promote the automatic execution of learned responses.

  16. An adaptive method with weight matrix as a function of the state to design the rotatory flexible system control law

    NASA Astrophysics Data System (ADS)

    Souza, Luiz C. G.; Bigot, P.

    2016-10-01

    One of the most well-known techniques of optimal control is the theory of Linear Quadratic Regulator (LQR). This method was originally applied only to linear systems but has been generalized for non-linear systems: the State Dependent Riccati Equation (SDRE) technique. One of the advantages of SDRE is that the weight matrix selection is the same as in LQR. The difference is that weights are not necessarily constant: they can be state dependent. Then, it gives an additional flexibility to design the control law. Many are applications of SDRE for simulation or real time control but generally SDRE weights are chosen constant so no advantage of this flexibility is taken. This work serves to show through simulation that state dependent weights matrix can improve SDRE control performance. The system is a non-linear flexible rotatory beam. In a brief first part SDRE theory will be explained and the non-linear model detailed. Then, influence of SDRE weight matrix associated with the state Q will be analyzed to get some insight in order to assume a state dependent law. Finally, these laws are tested and compared to constant weight matrix Q. Based on simulation results; one concludes showing the benefits of using an adaptive weight Q rather than a constant one.

  17. Complete polarization characterization of single plasmonic nanoparticle enabled by a novel Dark-field Mueller matrix spectroscopy system

    PubMed Central

    Chandel, Shubham; Soni, Jalpa; Ray, Subir kumar; Das, Anwesh; Ghosh, Anirudha; Raj, Satyabrata; Ghosh, Nirmalya

    2016-01-01

    Information on the polarization properties of scattered light from plasmonic systems are of paramount importance due to fundamental interest and potential applications. However, such studies are severely compromised due to the experimental difficulties in recording full polarization response of plasmonic nanostructures. Here, we report on a novel Mueller matrix spectroscopic system capable of acquiring complete polarization information from single isolated plasmonic nanoparticle/nanostructure. The outstanding issues pertaining to reliable measurements of full 4 × 4 spectroscopic scattering Mueller matrices from single nanoparticle/nanostructures are overcome by integrating an efficient Mueller matrix measurement scheme and a robust eigenvalue calibration method with a dark-field microscopic spectroscopy arrangement. Feasibility of quantitative Mueller matrix polarimetry and its potential utility is illustrated on a simple plasmonic system, that of gold nanorods. The demonstrated ability to record full polarization information over a broad wavelength range and to quantify the intrinsic plasmon polarimetry characteristics via Mueller matrix inverse analysis should lead to a novel route towards quantitative understanding, analysis/interpretation of a number of intricate plasmonic effects and may also prove useful towards development of polarization-controlled novel sensing schemes. PMID:27212687

  18. General A 9 × 9 Matrix Representation of Birman—Wenzl—Murakami Algebra and Berry Phase in Yang—Baxter System

    NASA Astrophysics Data System (ADS)

    Gou, Li-Dan; Xue, Kang; Wang, Gang-Cheng

    2011-02-01

    We present a 9 × 9 S-matrix and E-matrix. A representation of specialized Birman—Wenzl—Murakami algebra is obtained. Starting from the given braid group representation S-matrix, we obtain the trigonometric solution of Yang-Baxter equation. A unitary matrix Ř(x, ϕ1,ϕ2) is generated via the Yang—Baxterization approach. Then we construct a Yang—Baxter Hamiltonian through the unitary matrix Ř(x, ϕ1,ϕ2). Berry phase of this Yang—Baxter system is investigated in detail.

  19. Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis.

    PubMed

    Clancy, Cornelius J; Nguyen, Minh-Ly; Cheng, Shaoji; Huang, Hong; Fan, Guixiang; Jaber, Reia A; Wingard, John R; Cline, Christina; Nguyen, M Hong

    2008-05-01

    Despite shortcomings, cultures of blood and sterile sites remain the "gold standard" for diagnosing systemic candidiasis. Alternative diagnostic markers, including antibody detection, have been developed, but none are widely accepted. In this study, we used an enzyme-linked immunosorbent assay to measure serum antibody responses against 15 recombinant Candida albicans antigens among 60 patients with systemic candidiasis due to various Candida spp. and 24 uninfected controls. Mean immunoglobulin G (IgG) responses against all 15 antigens were significantly higher among patients with systemic candidiasis than among controls, whereas IgM responses were higher against only seven antigens. Using discriminant analysis that included IgG responses against the 15 antigens, we derived a mathematical prediction model that identified patients with systemic candidiasis with an error rate of 3.7%, a sensitivity of 96.6%, and a specificity of 95.6%. Furthermore, a prediction model using a subset of four antigens (SET1, ENO1, PGK1-2, and MUC1-2) identified through backward elimination and canonical correlation analyses performed as accurately as the full panel. Using the simplified model, we predicted systemic candidiasis in a separate test sample of 32 patients and controls with 100% sensitivity and 87.5% specificity. We also demonstrated that IgG titers against each of the four antigens included in the prediction model were significantly higher in convalescent-phase sera than in paired acute-phase sera. Taken together, our findings suggest that IgG responses against a panel of candidal antigens might represent an accurate and early marker of systemic candidiasis, a hypothesis that should be tested in future trials.

  20. Linear matrix inequality-based nonlinear adaptive robust control with application to unmanned aircraft systems

    NASA Astrophysics Data System (ADS)

    Kun, David William

    Unmanned aircraft systems (UASs) are gaining popularity in civil and commercial applications as their lightweight on-board computers become more powerful and affordable, their power storage devices improve, and the Federal Aviation Administration addresses the legal and safety concerns of integrating UASs in the national airspace. Consequently, many researchers are pursuing novel methods to control UASs in order to improve their capabilities, dependability, and safety assurance. The nonlinear control approach is a common choice as it offers several benefits for these highly nonlinear aerospace systems (e.g., the quadrotor). First, the controller design is physically intuitive and is derived from well known dynamic equations. Second, the final control law is valid in a larger region of operation, including far from the equilibrium states. And third, the procedure is largely methodical, requiring less expertise with gain tuning, which can be arduous for a novice engineer. Considering these facts, this thesis proposes a nonlinear controller design method that combines the advantages of adaptive robust control (ARC) with the powerful design tools of linear matrix inequalities (LMI). The ARC-LMI controller is designed with a discontinuous projection-based adaptation law, and guarantees a prescribed transient and steady state tracking performance for uncertain systems in the presence of matched disturbances. The norm of the tracking error is bounded by a known function that depends on the controller design parameters in a known form. Furthermore, the LMI-based part of the controller ensures the stability of the system while overcoming polytopic uncertainties, and minimizes the control effort. This can reduce the number of parameters that require adaptation, and helps to avoid control input saturation. These desirable characteristics make the ARC-LMI control algorithm well suited for the quadrotor UAS, which may have unknown parameters and may encounter external

  1. R-matrix Analysis of Reactions in the {sup 9}B Compound System

    SciTech Connect

    Paris, M. Hale, G.; Hayes-Sterbenz, A.; Jungman, G.

    2014-06-15

    Recent activity in solving the ‘lithium problem’ in big bang nucleosynthesis has focused on the role that putative resonances may play in resonance-enhanced destruction of {sup 7}Li. Particular attention has been paid to the reactions involving the {sup 9}B compound nuclear system, d+{sup 7}Be→{sup 9}B. These reactions are analyzed via the multichannel, two-body unitary R-matrix method using the code EDA developed by Hale and collaborators. We employ much of the known elastic and reaction data, in a four-channel treatment. The data include elastic {sup 3}He+{sup 6}Li differential cross sections from 0.7 to 2.0 MeV, integrated reaction cross sections for energies from 0.7 to 5.0 MeV for {sup 6}Li({sup 3}He,p){sup 8}Be{sup *} and from 0.4 to 5.0 MeV for the {sup 6}Li({sup 3}He,d){sup 7}Be reaction. Capture data have been added to an earlier analysis with integrated cross section measurements from 0.7 to 0.825 MeV for {sup 6}Li({sup 3}He,γ){sup 9}B. The resulting resonance parameters are compared with tabulated values, and previously unidentified resonances are noted. Our results show that there are no near d+{sup 7}Be threshold resonances with widths that are 10's of keV and reduce the likelihood that a resonance-enhanced mass-7 destruction mechanism, as suggested in recently published work, can explain the {sup 7}Li problem.

  2. Periosteal Sharpey’s fibers: a novel bone matrix regulatory system?

    PubMed Central

    Aaron, Jean E.

    2012-01-01

    Sharpey’s “perforating” fibers (SF) are well known skeletally in tooth anchorage. Elsewhere they provide anchorage for the periosteum and are less well documented. Immunohistochemistry has transformed their potential significance by identifying their collagen type III (CIII) content and enabling their mapping in domains as permeating arrays of fibers (5–25 μ thick), protected from osteoclastic resorption by their poor mineralization. As periosteal extensions they are crucial in early skeletal development and central to intramembranous bone healing, providing unique microanatomical avenues for musculoskeletal exchange, their composition (e.g., collagen type VI, elastin, tenascin) combined with a multiaxial pattern of insertion suggesting a role more complex than attachment alone would justify. A proportion permeate the cortex to the endosteum (and beyond), fusing into a CIII-rich osteoid layer (<2 μ thick) encompassing all resting surfaces, and with which they apparently integrate into a PERIOSTEAL-SHARPEY FIBER-ENDOSTEUM (PSE) structural continuum. This intraosseous system behaves in favor of bone loss or gain depending upon extraneous stimuli (i.e., like Frost’s hypothetical “mechanostat”). Thus, the birefringent fibers are sensitive to humoral factors (e.g., estrogen causes retraction, rat femur model), physical activity (e.g., running causes expansion, rat model), aging (e.g., causes fragmentation, pig mandible model), and pathology (e.g., atrophied in osteoporosis, hypertrophied in osteoarthritis, human proximal femur), and with encroaching mineral particles hardening the usually soft parts. In this way the unobtrusive periosteal SF network may regulate bone status, perhaps even contributing to predictable “hotspots” of trabecular disconnection, particularly at sites of tension prone to fatigue, and with the network deteriorating significantly before bone matrix loss. PMID:22908007

  3. Robust pole assignment using velocity-acceleration feedback for second-order dynamical systems with singular mass matrix.

    PubMed

    Abdelaziz, Taha H S

    2015-07-01

    In this paper the robust pole assignment problem using combined velocity and acceleration feedback for second-order linear systems with singular mass matrix is illustrated. This is promising for better applicability in several practical applications where the acceleration signals are easier to obtain than the proportional ones. First, the explicit parametric expressions of both the feedback gain controller and the eigenvector matrix are derived. The parametric solution involves manipulations only on the original second-order model. The available degrees of freedom offered by the velocity-acceleration feedback in selecting the associated eigenvectors are utilized to improve robustness of the closed-loop system. Straight-forward computational algorithms are introduced to demonstrate the effectiveness of the proposed approach. These algorithms are applicable for a dynamical system with mass matrices that can be either singular or nonsingular. Numerical examples are provided to illustrate the application of the proposed procedure. PMID:25724296

  4. A Small Mammal Community in a Forest Fragment, Vegetation Corridor and Coffee Matrix System in the Brazilian Atlantic Forest

    PubMed Central

    Rocha, Mariana Ferreira; Passamani, Marcelo; Louzada, Júlio

    2011-01-01

    The objective of our work was to verify the value of the vegetation corridor in the conservation of small mammals in fragmented tropical landscapes, using a model system in the southeastern Minas Gerais. We evaluated and compared the composition and structure of small mammals in a vegetation corridor, forest fragments and a coffee matrix. A total of 15 species were recorded, and the highest species richness was observed in the vegetation corridor (13 species), followed by the forest fragments (10) and the coffee matrix (6). The absolute abundance was similar between the vegetation corridor and fragments (F = 22.94; p = 0.064), and the greatest differences occurred between the vegetation corridor and the matrix (F = 22.94; p = 0.001) and the forest fragments and the matrix (F = 22.94; p = 0.007). Six species showed significant habitat preference possibly related to the sensitivity of the species to the forest disturbance. Marmosops incanus was the species most sensitive to disturbance; Akodon montensis, Cerradomys subflavus, Gracilinanus microtarsus and Rhipidomys sp. displayed little sensitivity to disturbance, with a high relative abundance in the vegetation corridor. Calomys sp. was the species least affected by habitat disturbance, displaying a high relative abundance in the coffee matrix. Although the vegetation corridors are narrow (4 m width), our results support the hypothesis in which they work as a forest extension, share most species with the forest fragment and support species richness and abundance closer to forest fragments than to the coffee matrix. Our work highlights the importance and cost-effectiveness of these corridors to biodiversity management in the fragmented Atlantic Forest landscapes and at the regional level. PMID:21912591

  5. Integrating GPS, GYRO, vehicle speed sensor, and digital map to provide accurate and real-time position in an intelligent navigation system

    NASA Astrophysics Data System (ADS)

    Li, Qingquan; Fang, Zhixiang; Li, Hanwu; Xiao, Hui

    2005-10-01

    The global positioning system (GPS) has become the most extensively used positioning and navigation tool in the world. Applications of GPS abound in surveying, mapping, transportation, agriculture, military planning, GIS, and the geosciences. However, the positional and elevation accuracy of any given GPS location is prone to error, due to a number of factors. The applications of Global Positioning System (GPS) positioning is more and more popular, especially the intelligent navigation system which relies on GPS and Dead Reckoning technology is developing quickly for future huge market in China. In this paper a practical combined positioning model of GPS/DR/MM is put forward, which integrates GPS, Gyro, Vehicle Speed Sensor (VSS) and digital navigation maps to provide accurate and real-time position for intelligent navigation system. This model is designed for automotive navigation system making use of Kalman filter to improve position and map matching veracity by means of filtering raw GPS and DR signals, and then map-matching technology is used to provide map coordinates for map displaying. In practical examples, for illustrating the validity of the model, several experiments and their results of integrated GPS/DR positioning in intelligent navigation system will be shown for the conclusion that Kalman Filter based GPS/DR integrating position approach is necessary, feasible and efficient for intelligent navigation application. Certainly, this combined positioning model, similar to other model, can not resolve all situation issues. Finally, some suggestions are given for further improving integrated GPS/DR/MM application.

  6. An Accurate and Fault-Tolerant Target Positioning System for Buildings Using Laser Rangefinders and Low-Cost MEMS-Based MARG Sensors.

    PubMed

    Zhao, Lin; Guan, Dongxue; Landry, René; Cheng, Jianhua; Sydorenko, Kostyantyn

    2015-01-01

    Target positioning systems based on MEMS gyros and laser rangefinders (LRs) have extensive prospects due to their advantages of low cost, small size and easy realization. The target positioning accuracy is mainly determined by the LR's attitude derived by the gyros. However, the attitude error is large due to the inherent noises from isolated MEMS gyros. In this paper, both accelerometer/magnetometer and LR attitude aiding systems are introduced to aid MEMS gyros. A no-reset Federated Kalman Filter (FKF) is employed, which consists of two local Kalman Filters (KF) and a Master Filter (MF). The local KFs are designed by using the Direction Cosine Matrix (DCM)-based dynamic equations and the measurements from the two aiding systems. The KFs can estimate the attitude simultaneously to limit the attitude errors resulting from the gyros. Then, the MF fuses the redundant attitude estimates to yield globally optimal estimates. Simulation and experimental results demonstrate that the FKF-based system can improve the target positioning accuracy effectively and allow for good fault-tolerant capability.

  7. An Accurate and Fault-Tolerant Target Positioning System for Buildings Using Laser Rangefinders and Low-Cost MEMS-Based MARG Sensors

    PubMed Central

    Zhao, Lin; Guan, Dongxue; Landry, René Jr.; Cheng, Jianhua; Sydorenko, Kostyantyn

    2015-01-01

    Target positioning systems based on MEMS gyros and laser rangefinders (LRs) have extensive prospects due to their advantages of low cost, small size and easy realization. The target positioning accuracy is mainly determined by the LR’s attitude derived by the gyros. However, the attitude error is large due to the inherent noises from isolated MEMS gyros. In this paper, both accelerometer/magnetometer and LR attitude aiding systems are introduced to aid MEMS gyros. A no-reset Federated Kalman Filter (FKF) is employed, which consists of two local Kalman Filters (KF) and a Master Filter (MF). The local KFs are designed by using the Direction Cosine Matrix (DCM)-based dynamic equations and the measurements from the two aiding systems. The KFs can estimate the attitude simultaneously to limit the attitude errors resulting from the gyros. Then, the MF fuses the redundant attitude estimates to yield globally optimal estimates. Simulation and experimental results demonstrate that the FKF-based system can improve the target positioning accuracy effectively and allow for good fault-tolerant capability. PMID:26512672

  8. Random matrix models for decoherence and fidelity decay in quantum information systems

    NASA Astrophysics Data System (ADS)

    Pineda, Carlos; Seligman, Thomas H.

    2008-03-01

    This course aims to introduce the student to random matrix models for decoherence and fidelity decay. They present a very powerful alternate approach, that emphasizes the disordered character of many environments and uncontrollable perturbations/couplings. The inherent integrability of such models makes analytic studies possible. We limit our considerations to linear response treatment, as high fidelity and small decoherence are the backbone of quantum information processes. For fidelity decay, where experimental results are available, a comparison with experiments shows excellent agreement with random matrix theory predictions.

  9. Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix.

    PubMed

    Gill, Hasreet K; Cohen, Jennifer D; Ayala-Figueroa, Jesus; Forman-Rubinsky, Rachel; Poggioli, Corey; Bickard, Kevin; Parry, Jean M; Pu, Pu; Hall, David H; Sundaram, Meera V

    2016-08-01

    Most epithelial cells secrete a glycoprotein-rich apical extracellular matrix that can have diverse but still poorly understood roles in development and physiology. Zona Pellucida (ZP) domain glycoproteins are common constituents of these matrices, and their loss in humans is associated with a number of diseases. Understanding of the functions, organization and regulation of apical matrices has been hampered by difficulties in imaging them both in vivo and ex vivo. We identified the PAN-Apple, mucin and ZP domain glycoprotein LET-653 as an early and transient apical matrix component that shapes developing epithelia in C. elegans. LET-653 has modest effects on shaping of the vulva and epidermis, but is essential to prevent lumen fragmentation in the very narrow, unicellular excretory duct tube. We were able to image the transient LET-653 matrix by both live confocal imaging and transmission electron microscopy. Structure/function and fluorescence recovery after photobleaching studies revealed that LET-653 exists in two separate luminal matrix pools, a loose fibrillar matrix in the central core of the lumen, to which it binds dynamically via its PAN domains, and an apical-membrane-associated matrix, to which it binds stably via its ZP domain. The PAN domains are both necessary and sufficient to confer a cyclic pattern of duct lumen localization that precedes each molt, while the ZP domain is required for lumen integrity. Ectopic expression of full-length LET-653, but not the PAN domains alone, could expand lumen diameter in the developing gut tube, where LET-653 is not normally expressed. Together, these data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter. These data identify a transient apical matrix component present prior to cuticle secretion in C. elegans, demonstrate critical roles for

  10. Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix

    PubMed Central

    Ayala-Figueroa, Jesus; Parry, Jean M.; Pu, Pu; Hall, David H.

    2016-01-01

    Most epithelial cells secrete a glycoprotein-rich apical extracellular matrix that can have diverse but still poorly understood roles in development and physiology. Zona Pellucida (ZP) domain glycoproteins are common constituents of these matrices, and their loss in humans is associated with a number of diseases. Understanding of the functions, organization and regulation of apical matrices has been hampered by difficulties in imaging them both in vivo and ex vivo. We identified the PAN-Apple, mucin and ZP domain glycoprotein LET-653 as an early and transient apical matrix component that shapes developing epithelia in C. elegans. LET-653 has modest effects on shaping of the vulva and epidermis, but is essential to prevent lumen fragmentation in the very narrow, unicellular excretory duct tube. We were able to image the transient LET-653 matrix by both live confocal imaging and transmission electron microscopy. Structure/function and fluorescence recovery after photobleaching studies revealed that LET-653 exists in two separate luminal matrix pools, a loose fibrillar matrix in the central core of the lumen, to which it binds dynamically via its PAN domains, and an apical-membrane-associated matrix, to which it binds stably via its ZP domain. The PAN domains are both necessary and sufficient to confer a cyclic pattern of duct lumen localization that precedes each molt, while the ZP domain is required for lumen integrity. Ectopic expression of full-length LET-653, but not the PAN domains alone, could expand lumen diameter in the developing gut tube, where LET-653 is not normally expressed. Together, these data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter. These data identify a transient apical matrix component present prior to cuticle secretion in C. elegans, demonstrate critical roles for

  11. Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix.

    PubMed

    Gill, Hasreet K; Cohen, Jennifer D; Ayala-Figueroa, Jesus; Forman-Rubinsky, Rachel; Poggioli, Corey; Bickard, Kevin; Parry, Jean M; Pu, Pu; Hall, David H; Sundaram, Meera V

    2016-08-01

    Most epithelial cells secrete a glycoprotein-rich apical extracellular matrix that can have diverse but still poorly understood roles in development and physiology. Zona Pellucida (ZP) domain glycoproteins are common constituents of these matrices, and their loss in humans is associated with a number of diseases. Understanding of the functions, organization and regulation of apical matrices has been hampered by difficulties in imaging them both in vivo and ex vivo. We identified the PAN-Apple, mucin and ZP domain glycoprotein LET-653 as an early and transient apical matrix component that shapes developing epithelia in C. elegans. LET-653 has modest effects on shaping of the vulva and epidermis, but is essential to prevent lumen fragmentation in the very narrow, unicellular excretory duct tube. We were able to image the transient LET-653 matrix by both live confocal imaging and transmission electron microscopy. Structure/function and fluorescence recovery after photobleaching studies revealed that LET-653 exists in two separate luminal matrix pools, a loose fibrillar matrix in the central core of the lumen, to which it binds dynamically via its PAN domains, and an apical-membrane-associated matrix, to which it binds stably via its ZP domain. The PAN domains are both necessary and sufficient to confer a cyclic pattern of duct lumen localization that precedes each molt, while the ZP domain is required for lumen integrity. Ectopic expression of full-length LET-653, but not the PAN domains alone, could expand lumen diameter in the developing gut tube, where LET-653 is not normally expressed. Together, these data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter. These data identify a transient apical matrix component present prior to cuticle secretion in C. elegans, demonstrate critical roles for

  12. The role of oral controlled release matrix tablets in drug delivery systems.

    PubMed

    Nokhodchi, Ali; Raja, Shaista; Patel, Pryia; Asare-Addo, Kofi

    2012-01-01

    Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years. This type of drug delivery has been at the centre of research due to its many benefits over conventional dosage. The focus of this review is on matrix tablets due to their widely use and simplicity of the formulation. This includes the discussion of various types of matrix tablets and factors affecting the drug release from these formulations. The mechanism of drug release from HPMC matrices is also discussed. PMID:23678458

  13. Variational matrix product ansatz for dispersion relations

    NASA Astrophysics Data System (ADS)

    Haegeman, Jutho; Pirvu, Bogdan; Weir, David J.; Cirac, J. Ignacio; Osborne, Tobias J.; Verschelde, Henri; Verstraete, Frank

    2012-03-01

    A variational ansatz for momentum eigenstates of translation-invariant quantum spin chains is formulated. The matrix product state ansatz works directly in the thermodynamic limit and allows for an efficient implementation (cubic scaling in the bond dimension) of the variational principle. Unlike previous approaches, the ansatz includes topologically nontrivial states (kinks, domain walls) for systems with symmetry breaking. The method is benchmarked using the spin-½ XXZ antiferromagnet and the spin-1 Heisenberg antiferromagnet, and we obtain surprisingly accurate results.

  14. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  15. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  16. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  17. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  18. 38 CFR 4.46 - Accurate measurement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Accurate measurement. 4... RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.46 Accurate measurement. Accurate measurement of the length of stumps, excursion of joints, dimensions and location of scars with respect...

  19. New Method for Accurate Calibration of Micro-Channel Plate based Detection Systems and its use in the Fast Plasma Investigation of NASA's Magnetospheric MultiScale Mission

    NASA Astrophysics Data System (ADS)

    Gliese, U.; Avanov, L. A.; Barrie, A.; Kujawski, J. T.; Mariano, A. J.; Tucker, C. J.; Chornay, D. J.; Cao, N. T.; Zeuch, M.; Pollock, C. J.; Jacques, A. D.

    2013-12-01

    The Fast Plasma Investigation (FPI) of the NASA Magnetospheric MultiScale (MMS) mission employs 16 Dual Electron Spectrometers (DESs) and 16 Dual Ion Spectrometers (DISs) with 4 of each type on each of 4 spacecraft to enable fast (30ms for electrons; 150ms for ions) and spatially differentiated measurements of full the 3D particle velocity distributions. This approach presents a new and challenging aspect to the calibration and operation of these instruments on ground and in flight. The response uniformity and reliability of their calibration and the approach to handling any temporal evolution of these calibrated characteristics all assume enhanced importance in this application, where we attempt to understand the meaning of particle distributions within the ion and electron diffusion regions. Traditionally, the micro-channel plate (MCP) based detection systems for electrostatic particle spectrometers have been calibrated by setting a fixed detection threshold and, subsequently, measuring a detection system count rate plateau curve to determine the MCP voltage that ensures the count rate has reached a constant value independent of further variation in the MCP voltage. This is achieved when most of the MCP pulse height distribution (PHD) is located at higher values (larger pulses) than the detection amplifier threshold. This method is adequate in single-channel detection systems and in multi-channel detection systems with very low crosstalk between channels. However, in dense multi-channel systems, it can be inadequate. Furthermore, it fails to fully and individually characterize each of the fundamental parameters of the detection system. We present a new detection system calibration method that enables accurate and repeatable measurement and calibration of MCP gain, MCP efficiency, signal loss due to variation in gain and efficiency, crosstalk from effects both above and below the MCP, noise margin, and stability margin in one single measurement. The fundamental

  20. Data and Knowledge Base on the Basis of the Expanded Matrix Model of Their Representation for the Intelligent System of Road-Climatic Zoning of Territories

    NASA Astrophysics Data System (ADS)

    Yankovskaya, A.; Cherepanov, D.; Selivanikova, O.

    2016-08-01

    An extended matrix model of data and knowledge representation on the investigated area, as well as a matrix model of data representation on the territory under investigation, are proposed for the intelligent system of road-climatic zoning of territories (RCZT) - the main information technology of RCZT. A part of the West Siberian region has been selected as the investigated territory. The extended matrix model of knowledge representation is filled out by knowledge engineers with participation of highly qualified experts in the field of RCZT. The matrix model of data representation on the territory under investigation is filled out by persons concerned in RCZT of the motor-roads management system.

  1. BD PuraMatrix peptide hydrogel as a culture system for human fetal Schwann cells in spinal cord regeneration.

    PubMed

    Moradi, Fateme; Bahktiari, Mehrdad; Joghataei, Mohammad Taghi; Nobakht, Maliheh; Soleimani, Masoud; Hasanzadeh, Gholamreza; Fallah, Ali; Zarbakhsh, Sam; Hejazian, Leila Beigom; Shirmohammadi, Maryam; Maleki, Fatemeh

    2012-12-01

    BD PuraMatrix peptide hydrogel, a three-dimensional cell culture model of nanofiber scaffold derived from the self-assembling peptide RADA16, has been applied to regenerative tissue repair in order to develop novel nanomedicine systems. In this study with PuraMatrix, self-assembling nanofiber scaffold (SAPNS) and Schwann cells (SCs) were isolated from human fetal sciatic nerves, cultured within SAPNS, and then transplanted into the spinal cord after injury (SCI) in rats. First, the peptide nanofiber scaffold was evaluated via scanning electron microscopy and atomic force microscopy. With phase-contrast microscopy, the appearance of representative human fetal SCs encapsulated in PuraMatrix on days 3, 5, and 7 in 12-well plates was revealed. The Schwann cells in PuraMatrix were cultured for 2 days, and the SCs had active proliferative potential. Spinal cord injury was induced by placing a 35-g weight on the dura of T9-T10 segments for 15 min, followed by in vivo treatment with SAPNS and human fetal SCs (100,000 cells/10 μl/injection) grafted into spinal cord 7 days after SCI. After treatment, the recovery of motor function was assessed periodically using the Basso, Beattie, and Bresnahan scoring system. Eight weeks after grafting, animals were perfusion fixed, and the survival of implanted cells was analyzed with antibody recognizing SCs. Immunohistochemical analysis of grafted lumber segments at 8 weeks after grafting revealed reduced asterogliosis and considerably increased infiltration of endogenous S100(+) cells into the injury site, suggesting that PuraMatrix may play an important role in the repair observed after SAPNS and human fetal SC transplantation.

  2. The Heat Output of the Waimangu, Waiotapu-Waikite and Reporoa Geothermal Systems (NZ): Do Chloride Fluxes Provide an Accurate Measure?

    SciTech Connect

    Bibby, H.M.; Glover, R.B.; Whiteford, P.C.

    1995-01-01

    Geothermal waters from the Waimangu, Waiotapu-Waikite and Reporoa geothermal systems find their way into three separate watersheds. The heat flow data from each of these drainage areas have been assessed making it possible to compare the heat outputs from two independent methods: direct heat measurements and the chloride flux method. For both the Waiotapu/Reporoa Valley drainage and the Waikite drainage a discrepancy exists between the two assessments, with the heat output observed at the surface (Waiotapu-540 {+-} 110 MW; Waikite-80 MW) nearly double of that calculated from the chloride flux (300 MW; 36 MW respectively). It appears that much of the throughput of chloride does not reach the surface within the area which was monitored and the basic assumption on which the method is based has been violated. For Waimangu the direct heat output is assessed as 510 {+-} 60 MW. However the ratio of enthalpy to chloride concentration of the source fluid is not well determined. Depending on the ratio chosen the heat output could lie between 360 and 800 MW. Although the chloride flux is accurately known, the heat output cannot be measured accurately without well determined data on the source fluid at depth.

  3. Evidence of Heterosynaptic LTD in the Human Nociceptive System: Superficial Skin Neuromodulation Using a Matrix Electrode Reduces Deep Pain Sensitivity

    PubMed Central

    Mücke, Martin; Cuhls, Henning; Radbruch, Lukas; Weigl, Tobias; Rolke, Roman

    2014-01-01

    Long term depression (LTD) is a neuronal learning mechanism after low frequency stimulation (LFS). This study compares two types of electrodes (concentric vs. matrix) and stimulation frequencies (4 and 30 Hz) to examine homo- and heterosynaptic effects indirectly depicted from the somatosensory profile of healthy subjects. Both electrodes were compared in a prospective, randomized, controlled cross-over study using 4 Hz as the conditioning LFS compared to 30 Hz (intended sham condition). Quantitative sensory testing (QST) was used to examine 13 thermal and mechanical detection and pain thresholds. Sixteen healthy volunteers (10 women, age 31.0±12.7 years) were examined. Depending on the electrodes and frequencies used a divergent pattern of sensory minus signs occurred. Using LFS the concentric electrode increased thermal thresholds, while the matrix electrode rather increased mechanical including deep pain thresholds. Findings after cutaneous neuromodulation using LFS and a matrix electrode are consistent with the concept of heterosynaptic LTD in the human nociceptive system, where deep pain sensitivity was reduced after superficial stimulation of intraepidermal nerve fibres. Cutaneous neuromodulation using LFS and a matrix electrode may be a useful tool to influence deep pain sensitivity in a variety of chronic pain syndromes. PMID:25229556

  4. Volatile fractionation in the early solar system and chondrule/matrix complementarity

    PubMed Central

    Bland, Philip A.; Alard, Olivier; Benedix, Gretchen K.; Kearsley, Anton T.; Menzies, Olwyn N.; Watt, Lauren E.; Rogers, Nick W.

    2005-01-01

    Bulk chondritic meteorites and terrestrial planets show a monotonic depletion in moderately volatile and volatile elements relative to the Sun's photosphere and CI carbonaceous chondrites. Although volatile depletion was the most fundamental chemical process affecting the inner solar nebula, debate continues as to its cause. Carbonaceous chondrites are the most primitive rocks available to us, and fine-grained, volatile-rich matrix is the most primitive component in these rocks. Several volatile depletion models posit a pristine matrix, with uniform CI-like chemistry across the different chondrite groups. To understand the nature of volatile fractionation, we studied minor and trace element abundances in fine-grained matrices of a variety of carbonaceous chondrites. We find that matrix trace element abundances are characteristic for a given chondrite group; they are depleted relative to CI chondrites, but are enriched relative to bulk compositions of their parent meteorites, particularly in volatile siderophile and chalcophile elements. This enrichment produces a highly nonmonotonic trace element pattern that requires a complementary depletion in chondrule compositions to achieve a monotonic bulk. We infer that carbonaceous chondrite matrices are not pristine: they formed from a material reservoir that was already depleted in volatile and moderately volatile elements. Additional thermal processing occurred during chondrule formation, with exchange of volatile siderophile and chalcophile elements between chondrules and matrix. This chemical complementarity shows that these chondritic components formed in the same nebula region. PMID:16174733

  5. Matrix metalloproteinase-3 in the central nervous system: a look on the bright side.

    PubMed

    Van Hove, Inge; Lemmens, Kim; Van de Velde, Sarah; Verslegers, Mieke; Moons, Lieve

    2012-10-01

    Matrix metalloproteinases (MMPs) are a large family of proteases involved in many cell-matrix and cell-cell signalling processes through activation, inactivation or release of extracellular matrix (ECM) and non-ECM molecules, such as growth factors and receptors. Uncontrolled MMP activities underlie the pathophysiology of many disorders. Also matrix metalloproteinase-3 (MMP-3) or stromelysin-1 contributes to several pathologies, such as cancer, asthma and rheumatoid arthritis, and has also been associated with neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and multiple sclerosis. However, based on defined MMP spatiotemporal expression patterns, the identification of novel candidate molecular targets and in vitro and in vivo studies, a beneficial role for MMPs in CNS physiology and recovery is emerging. The main purpose of this review is to shed light on the recently identified roles of MMP-3 in normal brain development and in plasticity and regeneration after CNS injury and disease. As such, MMP-3 is correlated with neuronal migration and neurite outgrowth and guidance in the developing CNS and contributes to synaptic plasticity and learning in the adult CNS. Moreover, a strict spatiotemporal MMP-3 up-regulation in the injured or diseased CNS might support remyelination and neuroprotection, as well as genesis and migration of stem cells in the damaged brain.

  6. Computer programs for calculation of matrix stability and frequency response from a state-space system description

    NASA Technical Reports Server (NTRS)

    Seidel, R. C.

    1974-01-01

    FORTRAN computer subroutines stemming from requirements to process state variable system equations for systems of high order are presented. They find the characteristic equation of a matrix using the method of Danilevsky, the number of roots with positive real parts using the Routh-Horwitz alternate formulation, convert a state variable system description to a Laplace transfer function using the method of Bollinger, and evaluate that transfer function and obtain its frequency response. A sample problem is presented to demonstrate use of the subroutines.

  7. Matrix System for Provision of Performance Characteristics of Gte Heavy-Duty parts at the Design Stage of Technological Processes

    NASA Astrophysics Data System (ADS)

    Kozhina, T. D.; Eroshkov, V. Yu

    2016-04-01

    The paper highlights the methods to assign technological conditions for machining providing the required performance characteristics due to control of quality parameters of a surface layer and machining accuracy. Assignment of technological conditions for machining is performed at the design stage of technological conditions in accordance with the methods developed based on the matrix system of analysis and computation of groups of technological and operational factors.

  8. Comparison of basis functions for 3D PET reconstruction using a Monte Carlo system matrix

    NASA Astrophysics Data System (ADS)

    Cabello, Jorge; Rafecas, Magdalena

    2012-04-01

    In emission tomography, iterative statistical methods are accepted as the reconstruction algorithms that achieve the best image quality. The accuracy of these methods relies partly on the quality of the system response matrix (SRM) that characterizes the scanner. The more physical phenomena included in the SRM, the higher the SRM quality, and therefore higher image quality is obtained from the reconstruction process. High-resolution small animal scanners contain as many as 103-104 small crystal pairs, while the field of view (FOV) is divided into hundreds of thousands of small voxels. These two characteristics have a significant impact on the number of elements to be calculated in the SRM. Monte Carlo (MC) methods have gained popularity as a way of calculating the SRM, due to the increased accuracy achievable, at the cost of introducing some statistical noise and long simulation times. In the work presented here the SRM is calculated using MC methods exploiting the cylindrical symmetries of the scanner, significantly reducing the simulation time necessary to calculate a high statistical quality SRM and the storage space necessary. The use of cylindrical symmetries makes polar voxels a convenient basis function. Alternatively, spherically symmetric basis functions result in improved noise properties compared to cubic and polar basis functions. The quality of reconstructed images using polar voxels, spherically symmetric basis functions on a polar grid, cubic voxels and post-reconstruction filtered polar and cubic voxels is compared from a noise and spatial resolution perspective. This study demonstrates that polar voxels perform as well as cubic voxels, reducing the simulation time necessary to calculate the SRM and the disk space necessary to store it. Results showed that spherically symmetric functions outperform polar and cubic basis functions in terms of noise properties, at the cost of slightly degraded spatial resolution, larger SRM file size and longer

  9. Aqueous two-phase systems for enhancing immunoassay sensitivity: simultaneous concentration of mycotoxins and neutralization of matrix interference.

    PubMed

    Soares, R R G; Novo, P; Azevedo, A M; Fernandes, P; Chu, V; Conde, J P; Aires-Barros, M R

    2014-09-26

    Immunoassays have a broad application range, from environmental and food toxicology to biomedical analysis, providing rapid and simple methods for analyte quantification. Immunoassays, however, are often challenging at nM and sub nM concentrations and are affected by detrimental matrix interference effects, as is the case of the detection of ochratoxin A (OTA) and Aflatoxin B1 (AFB1). These are widespread mycotoxins found in food and feed, with serious potential implications for human health. This work demonstrates the use of polymer-salt aqueous two phase systems (ATPSs) for the simultaneous concentration of mycotoxins and neutralization of matrix interference. In particular, polyethylene glycol (PEG)-phosphate salt ATPSs were used to enhance the detection sensitivity of OTA and AFB1 in wines and beer by an indirect competitive ELISA. Using this methodology it was possible to quantify both analytes spiked in red wine with limits-of-detection (LoD) down to 0.19 ng/mL and 0.035 ng/mL, respectively, with results comparable to those obtained using solutions of toxins in phosphate buffered saline (PBS) buffer (0.7 ng/mL and 0.009 ng/mL, respectively). Furthermore, a very low matrix-to matrix variability was observed, with LoD and half inhibitory concentration (IC50) values of 5.17 ± 1.08 and 33.2 ± 3.5 ng/mL (±SD) obtained in the detection of OTA spiked in red and white wines, beer or PBS buffer. These results indicate the potential of ATPS as a fast and simple concentration step and in providing matrix-independent analyte quantification for enhanced immunoassay sensitivity below regulatory levels. PMID:25152491

  10. A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS)

    PubMed Central

    Demircan, Kadir; Cömertoğlu, İsmail; Akyol, Sümeyya; Yiğitoğlu, Beyza Nur; Sarıkaya, Esma

    2014-01-01

    Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In addition, in the pathogenesis of cancer, inflammation, arthritis, and connective tissue diseases, ADAMTS proteinases have crucial roles. The purpose of this review is to collect previous studies about obstetrics and gynecology that are related to ADAMTS enzymes and discuss the subject in many aspects to give an idea to the investigators who are interested in the subject. PMID:25584036

  11. On the determination of the crystal-vapor surface free energy, and why a Gaussian expression can be accurate for a system far from Gaussian

    NASA Astrophysics Data System (ADS)

    Modak, Viraj P.; Wyslouzil, Barbara E.; Singer, Sherwin J.

    2016-08-01

    The crystal-vapor surface free energy γ is an important physical parameter governing physical processes, such as wetting and adhesion. We explore exact and approximate routes to calculate γ based on cleaving an intact crystal into non-interacting sub-systems with crystal-vapor interfaces. We do this by turning off the interactions, ΔV, between the sub-systems. Using the soft-core scheme for turning off ΔV, we find that the free energy varies smoothly with the coupling parameter λ, and a single thermodynamic integration yields the exact γ. We generate another exact method, and a cumulant expansion for γ by expressing the surface free energy in terms of an average of e-βΔV in the intact crystal. The second cumulant, or Gaussian approximation for γ is surprisingly accurate in most situations, even though we find that the underlying probability distribution for ΔV is clearly not Gaussian. We account for this fact by developing a non-Gaussian theory for γ and find that the difference between the non-Gaussian and Gaussian expressions for γ consist of terms that are negligible in many situations. Exact and approximate methods are applied to the (111) surface of a Lennard-Jones crystal and are also tested for more complex molecular solids, the surface of octane and nonadecane. Alkane surfaces were chosen for study because their crystal-vapor surface free energy has been of particular interest for understanding surface freezing in these systems.

  12. On the determination of the crystal-vapor surface free energy, and why a Gaussian expression can be accurate for a system far from Gaussian.

    PubMed

    Modak, Viraj P; Wyslouzil, Barbara E; Singer, Sherwin J

    2016-08-01

    The crystal-vapor surface free energy γ is an important physical parameter governing physical processes, such as wetting and adhesion. We explore exact and approximate routes to calculate γ based on cleaving an intact crystal into non-interacting sub-systems with crystal-vapor interfaces. We do this by turning off the interactions, ΔV, between the sub-systems. Using the soft-core scheme for turning off ΔV, we find that the free energy varies smoothly with the coupling parameter λ, and a single thermodynamic integration yields the exact γ. We generate another exact method, and a cumulant expansion for γ by expressing the surface free energy in terms of an average of e(-βΔV) in the intact crystal. The second cumulant, or Gaussian approximation for γ is surprisingly accurate in most situations, even though we find that the underlying probability distribution for ΔV is clearly not Gaussian. We account for this fact by developing a non-Gaussian theory for γ and find that the difference between the non-Gaussian and Gaussian expressions for γ consist of terms that are negligible in many situations. Exact and approximate methods are applied to the (111) surface of a Lennard-Jones crystal and are also tested for more complex molecular solids, the surface of octane and nonadecane. Alkane surfaces were chosen for study because their crystal-vapor surface free energy has been of particular interest for understanding surface freezing in these systems.

  13. Circuit theory and full counting statistics of charge transfer through mesoscopic systems: A random-matrix approach

    NASA Astrophysics Data System (ADS)

    Duarte-Filho, G. C.; Macedo-Junior, A. F.; Macêdo, A. M. S.

    2007-08-01

    We introduce a random-matrix description of full counting statistics of charge transfer through a quantum mesoscopic system at finite temperature in the presence two nonideal contacts. Using the exact map between random-matrix theory and the supersymmetric nonlinear σ model, we demonstrate, via explicit calculations, that the saddle-point equation, derived by applying the variational principle to the supersymmetric action, can be cast in the form of the two-terminal version of Nazarov’s circuit theory, thus giving it the status of a controlled approximation. For the case in which the mesoscopic system is a quantum dot at zero temperature, this circuit theory has recently been shown [A. L. R. Barbosa and A. M. S. Macêdo, Phys. Rev. B 71, 235307 (2005)] to reproduce exactly the asymptotic semiclassical limit of the Poisson kernel in perfect agreement with a diagrammatic approach for averaging over the unitary group. We report applications of our formalism to the description of charge transfer through a quantum dot, a quantum chain, and a quantum wire. We also discuss the role of different symmetry classes (orthogonal, unitary, and symplectic) and show how to use known exact connections between the supersymmetric nonlinear σ model and random scattering matrix theories to perform both perturbative and nonperturbative calculations. We believe that our results will help unify the various approaches being currently used in mesoscopic physics of hybrid devices within a single physically sound and mathematically rigorous theoretical scheme.

  14. Performances of the Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Rapid Identification of Bacteria in Routine Clinical Microbiology

    PubMed Central

    Grare, Marion; Prere, Marie-Françoise; Segonds, Christine; Marty, Nicole; Oswald, Eric

    2012-01-01

    Rapid and cost-effective matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS)-based systems will replace conventional phenotypic methods for routine identification of bacteria. We report here the first evaluation of the new MALDI-TOF MS-based Vitek MS system in a large clinical microbiology laboratory. This system uses an original spectrum classifier algorithm and a specific database designed for the identification of clinically relevant species. We have tested 767 routine clinical isolates representative of 50 genera and 124 species. Vitek MS-based identifications were performed by means of a single deposit on a MALDI disposable target without any prior extraction step and compared with reference identifications obtained mainly with the VITEK2 phenotypic system; if the identifications were discordant, molecular techniques provided reference identifications. The Vitek MS system provided 96.2% correct identifications to the species level (86.7%), to the genus level (8.2%), or within a range of species belonging to different genera (1.3%). Conversely, 1.3% of isolates were misidentified and 2.5% were unidentified, partly because the species was not included in the database; a second deposit provided a successful identification for 0.8% of isolates unidentified with the first deposit. The Vitek MS system is a simple, convenient, and accurate method for routine bacterial identification with a single deposit, considering the high bacterial diversity studied and as evidenced by the low prevalence of species without correct identification. In addition to a second deposit in uncommon cases, expanding the spectral database is expected to further enhance performances. PMID:22593596

  15. Performances of the Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid identification of bacteria in routine clinical microbiology.

    PubMed

    Dubois, Damien; Grare, Marion; Prere, Marie-Françoise; Segonds, Christine; Marty, Nicole; Oswald, Eric

    2012-08-01

    Rapid and cost-effective matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based systems will replace conventional phenotypic methods for routine identification of bacteria. We report here the first evaluation of the new MALDI-TOF MS-based Vitek MS system in a large clinical microbiology laboratory. This system uses an original spectrum classifier algorithm and a specific database designed for the identification of clinically relevant species. We have tested 767 routine clinical isolates representative of 50 genera and 124 species. Vitek MS-based identifications were performed by means of a single deposit on a MALDI disposable target without any prior extraction step and compared with reference identifications obtained mainly with the VITEK2 phenotypic system; if the identifications were discordant, molecular techniques provided reference identifications. The Vitek MS system provided 96.2% correct identifications to the species level (86.7%), to the genus level (8.2%), or within a range of species belonging to different genera (1.3%). Conversely, 1.3% of isolates were misidentified and 2.5% were unidentified, partly because the species was not included in the database; a second deposit provided a successful identification for 0.8% of isolates unidentified with the first deposit. The Vitek MS system is a simple, convenient, and accurate method for routine bacterial identification with a single deposit, considering the high bacterial diversity studied and as evidenced by the low prevalence of species without correct identification. In addition to a second deposit in uncommon cases, expanding the spectral database is expected to further enhance performances.

  16. Flexible body stability analysis of Space Shuttle ascent flight control system by using lambda matrix solution techniques

    NASA Technical Reports Server (NTRS)

    Bown, R. L.; Christofferson, A.; Lardas, M.; Flanders, H.

    1980-01-01

    A lambda matrix solution technique is being developed to perform an open loop frequency analysis of a high order dynamic system. The procedure evaluates the right and left latent vectors corresponding to the respective latent roots. The latent vectors are used to evaluate the partial fraction expansion formulation required to compute the flexible body open loop feedback gains for the Space Shuttle Digital Ascent Flight Control System. The algorithm is in the final stages of development and will be used to insure that the feedback gains meet the design specification.

  17. Observability Analysis of a Matrix Kalman Filter-Based Navigation System Using Visual/Inertial/Magnetic Sensors

    PubMed Central

    Feng, Guohu; Wu, Wenqi; Wang, Jinling

    2012-01-01

    A matrix Kalman filter (MKF) has been implemented for an integrated navigation system using visual/inertial/magnetic sensors. The MKF rearranges the original nonlinear process model in a pseudo-linear process model. We employ the observability rank criterion based on Lie derivatives to verify the conditions under which the nonlinear system is observable. It has been proved that such observability conditions are: (a) at least one degree of rotational freedom is excited, and (b) at least two linearly independent horizontal lines and one vertical line are observed. Experimental results have validated the correctness of these observability conditions. PMID:23012523

  18. Observability analysis of a matrix Kalman filter-based navigation system using visual/inertial/magnetic sensors.

    PubMed

    Feng, Guohu; Wu, Wenqi; Wang, Jinling

    2012-01-01

    A matrix Kalman filter (MKF) has been implemented for an integrated navigation system using visual/inertial/magnetic sensors. The MKF rearranges the original nonlinear process model in a pseudo-linear process model. We employ the observability rank criterion based on Lie derivatives to verify the conditions under which the nonlinear system is observable. It has been proved that such observability conditions are: (a) at least one degree of rotational freedom is excited, and (b) at least two linearly independent horizontal lines and one vertical line are observed. Experimental results have validated the correctness of these observability conditions.

  19. Shorter sampling periods and accurate estimates of milk volume and components are possible for pasture based dairy herds milked with automated milking systems.

    PubMed

    Kamphuis, Claudia; Burke, Jennie K; Taukiri, Sarah; Petch, Susan-Fay; Turner, Sally-Anne

    2016-08-01

    Dairy cows grazing pasture and milked using automated milking systems (AMS) have lower milking frequencies than indoor fed cows milked using AMS. Therefore, milk recording intervals used for herd testing indoor fed cows may not be suitable for cows on pasture based farms. We hypothesised that accurate standardised 24 h estimates could be determined for AMS herds with milk recording intervals of less than the Gold Standard (48 hs), but that the optimum milk recording interval would depend on the herd average for milking frequency. The Gold Standard protocol was applied on five commercial dairy farms with AMS, between December 2011 and February 2013. From 12 milk recording test periods, involving 2211 cow-test days and 8049 cow milkings, standardised 24 h estimates for milk volume and milk composition were calculated for the Gold Standard protocol and compared with those collected during nine alternative sampling scenarios, including six shorter sampling periods and three in which a fixed number of milk samples per cow were collected. Results infer a 48 h milk recording protocol is unnecessarily long for collecting accurate estimates during milk recording on pasture based AMS farms. Collection of two milk samples only per cow was optimal in terms of high concordance correlation coefficients for milk volume and components and a low proportion of missed cow-test days. Further research is required to determine the effects of diurnal variations in milk composition on standardised 24 h estimates for milk volume and components, before a protocol based on a fixed number of samples could be considered. Based on the results of this study New Zealand have adopted a split protocol for herd testing based on the average milking frequency for the herd (NZ Herd Test Standard 8100:2015). PMID:27600967

  20. CLARREO Cornerstone of the Earth Observing System: Measuring Decadal Change Through Accurate Emitted Infrared and Reflected Solar Spectra and Radio Occultation

    NASA Technical Reports Server (NTRS)

    Sandford, Stephen P.

    2010-01-01

    The Climate Absolute Radiance and Refractivity Observatory (CLARREO) is one of four Tier 1 missions recommended by the recent NRC Decadal Survey report on Earth Science and Applications from Space (NRC, 2007). The CLARREO mission addresses the need to provide accurate, broadly acknowledged climate records that are used to enable validated long-term climate projections that become the foundation for informed decisions on mitigation and adaptation policies that address the effects of climate change on society. The CLARREO mission accomplishes this critical objective through rigorous SI traceable decadal change observations that are sensitive to many of the key uncertainties in climate radiative forcings, responses, and feedbacks that in turn drive uncertainty in current climate model projections. These same uncertainties also lead to uncertainty in attribution of climate change to anthropogenic forcing. For the first time CLARREO will make highly accurate, global, SI-traceable decadal change observations sensitive to the most critical, but least understood, climate forcings, responses, and feedbacks. The CLARREO breakthrough is to achieve the required levels of accuracy and traceability to SI standards for a set of observations sensitive to a wide range of key decadal change variables. The required accuracy levels are determined so that climate trend signals can be detected against a background of naturally occurring variability. Climate system natural variability therefore determines what level of accuracy is overkill, and what level is critical to obtain. In this sense, the CLARREO mission requirements are considered optimal from a science value perspective. The accuracy for decadal change traceability to SI standards includes uncertainties associated with instrument calibration, satellite orbit sampling, and analysis methods. Unlike most space missions, the CLARREO requirements are driven not by the instantaneous accuracy of the measurements, but by accuracy in

  1. A fast accurate approximation method with multigrid solver for two-dimensional fractional sub-diffusion equation

    NASA Astrophysics Data System (ADS)

    Lin, Xue-lei; Lu, Xin; Ng, Micheal K.; Sun, Hai-Wei

    2016-10-01

    A fast accurate approximation method with multigrid solver is proposed to solve a two-dimensional fractional sub-diffusion equation. Using the finite difference discretization of fractional time derivative, a block lower triangular Toeplitz matrix is obtained where each main diagonal block contains a two-dimensional matrix for the Laplacian operator. Our idea is to make use of the block ɛ-circulant approximation via fast Fourier transforms, so that the resulting task is to solve a block diagonal system, where each diagonal block matrix is the sum of a complex scalar times the identity matrix and a Laplacian matrix. We show that the accuracy of the approximation scheme is of O (ɛ). Because of the special diagonal block structure, we employ the multigrid method to solve the resulting linear systems. The convergence of the multigrid method is studied. Numerical examples are presented to illustrate the accuracy of the proposed approximation scheme and the efficiency of the proposed solver.

  2. WE-A-17A-10: Fast, Automatic and Accurate Catheter Reconstruction in HDR Brachytherapy Using An Electromagnetic 3D Tracking System

    SciTech Connect

    Poulin, E; Racine, E; Beaulieu, L; Binnekamp, D

    2014-06-15

    Purpose: In high dose rate brachytherapy (HDR-B), actual catheter reconstruction protocols are slow and errors prompt. The purpose of this study was to evaluate the accuracy and robustness of an electromagnetic (EM) tracking system for improved catheter reconstruction in HDR-B protocols. Methods: For this proof-of-principle, a total of 10 catheters were inserted in gelatin phantoms with different trajectories. Catheters were reconstructed using a Philips-design 18G biopsy needle (used as an EM stylet) and the second generation Aurora Planar Field Generator from Northern Digital Inc. The Aurora EM system exploits alternating current technology and generates 3D points at 40 Hz. Phantoms were also scanned using a μCT (GE Healthcare) and Philips Big Bore clinical CT system with a resolution of 0.089 mm and 2 mm, respectively. Reconstructions using the EM stylet were compared to μCT and CT. To assess the robustness of the EM reconstruction, 5 catheters were reconstructed twice and compared. Results: Reconstruction time for one catheter was 10 seconds or less. This would imply that for a typical clinical implant of 17 catheters, the total reconstruction time would be less than 3 minutes. When compared to the μCT, the mean EM tip identification error was 0.69 ± 0.29 mm while the CT error was 1.08 ± 0.67 mm. The mean 3D distance error was found to be 0.92 ± 0.37 mm and 1.74 ± 1.39 mm for the EM and CT, respectively. EM 3D catheter trajectories were found to be significantly more accurate (unpaired t-test, p < 0.05). A mean difference of less than 0.5 mm was found between successive EM reconstructions. Conclusion: The EM reconstruction was found to be faster, more accurate and more robust than the conventional methods used for catheter reconstruction in HDR-B. This approach can be applied to any type of catheters and applicators. We would like to disclose that the equipments, used in this study, is coming from a collaboration with Philips Medical.

  3. Investigations on the effect of antioxidant type and concentration and model system matrix on acrylamide formation in model Maillard reaction systems.

    PubMed

    Constantinou, Costas; Koutsidis, Georgios

    2016-04-15

    The formation of acrylamide in model Maillard reaction systems containing phenolic compounds was examined, with regards to phenolic type, concentration, and model system matrix. In dry glyoxal/asparagine waxy maize starch (WMS) systems, 9 out of 10 examined phenolics demonstrated an inhibiting effect, with the most significant reductions (55-60%) observed for caffeoylquinic acids. In WMS glucose/asparagine systems, examination of three different concentrations (0.1, 0.5 and 1 μmol/g WMS) suggested a 'minimum effective concentration' for epicatechin and caffeic acid, whilst addition of caffeoylquinic acids resulted in dose-dependent acrylamide reduction (25-75%). The discordant results of further studies utilising different matrices (dry and wet-to-dry) indicated that, apart from the nature and chemical reactivity, the matrix and the physical state of the reactants might be important for acrylamide formation.

  4. Probabilistic models and numerical calculation of system matrix and sensitivity in list-mode MLEM 3D reconstruction of Compton camera images.

    PubMed

    Maxim, Voichita; Lojacono, Xavier; Hilaire, Estelle; Krimmer, Jochen; Testa, Etienne; Dauvergne, Denis; Magnin, Isabelle; Prost, Rémy

    2016-01-01

    This paper addresses the problem of evaluating the system matrix and the sensitivity for iterative reconstruction in Compton camera imaging. Proposed models and numerical calculation strategies are compared through the influence they have on the three-dimensional reconstructed images. The study attempts to address four questions. First, it proposes an analytic model for the system matrix. Second, it suggests a method for its numerical validation with Monte Carlo simulated data. Third, it compares analytical models of the sensitivity factors with Monte Carlo simulated values. Finally, it shows how the system matrix and the sensitivity calculation strategies influence the quality of the reconstructed images.

  5. Accurate monotone cubic interpolation

    NASA Technical Reports Server (NTRS)

    Huynh, Hung T.

    1991-01-01

    Monotone piecewise cubic interpolants are simple and effective. They are generally third-order accurate, except near strict local extrema where accuracy degenerates to second-order due to the monotonicity constraint. Algorithms for piecewise cubic interpolants, which preserve monotonicity as well as uniform third and fourth-order accuracy are presented. The gain of accuracy is obtained by relaxing the monotonicity constraint in a geometric framework in which the median function plays a crucial role.

  6. Accurate Finite Difference Algorithms

    NASA Technical Reports Server (NTRS)

    Goodrich, John W.

    1996-01-01

    Two families of finite difference algorithms for computational aeroacoustics are presented and compared. All of the algorithms are single step explicit methods, they have the same order of accuracy in both space and time, with examples up to eleventh order, and they have multidimensional extensions. One of the algorithm families has spectral like high resolution. Propagation with high order and high resolution algorithms can produce accurate results after O(10(exp 6)) periods of propagation with eight grid points per wavelength.

  7. Path integral molecular dynamics method based on a pair density matrix approximation: An algorithm for distinguishable and identical particle systems

    NASA Astrophysics Data System (ADS)

    Miura, Shinichi; Okazaki, Susumu

    2001-09-01

    In this paper, the path integral molecular dynamics (PIMD) method has been extended to employ an efficient approximation of the path action referred to as the pair density matrix approximation. Configurations of the isomorphic classical systems were dynamically sampled by introducing fictitious momenta as in the PIMD based on the standard primitive approximation. The indistinguishability of the particles was handled by a pseudopotential of particle permutation that is an extension of our previous one [J. Chem. Phys. 112, 10 116 (2000)]. As a test of our methodology for Boltzmann statistics, calculations have been performed for liquid helium-4 at 4 K. We found that the PIMD with the pair density matrix approximation dramatically reduced the computational cost to obtain the structural as well as dynamical (using the centroid molecular dynamics approximation) properties at the same level of accuracy as that with the primitive approximation. With respect to the identical particles, we performed the calculation of a bosonic triatomic cluster. Unlike the primitive approximation, the pseudopotential scheme based on the pair density matrix approximation described well the bosonic correlation among the interacting atoms. Convergence with a small number of discretization of the path achieved by this approximation enables us to construct a method of avoiding the problem of the vanishing pseudopotential encountered in the calculations by the primitive approximation.

  8. Some fundamental aspects of fault-tree and digraph-matrix relationships for a systems-interaction evaluation procedure

    SciTech Connect

    Alesso, H.P.

    1982-02-28

    Recent events, such as Three Mile Island-2, Brown's Ferry-3, and Crystal River-3, have demonstrated that complex accidents can occur as a result of dependent (common-cause/mode) failures. These events are now being called Systems Interactions. A procedure for the identification and evaluation of Systems Interactions is being developed by the NRC. Several national laboratories and utilities have contributed preliminary procedures. As a result, there are several important views of the Systems Interaction problem. This report reviews some fundamental mathematical background of both fault-oriented and success-oriented risk analyses in order to bring out the advantages and disadvantages of each. In addition, it outlines several fault-oriented/dependency analysis approaches and several success-oriented/digraph-matrix approaches. The objective is to obtain a broad perspective of present options for solving the Systems Interaction problem.

  9. The Microstructure-Processing-Property Relationships in an Al Matrix Composite System Reinforced by Al-Cu-Fe Alloy Particles

    SciTech Connect

    Tang, Fei

    2004-01-01

    the matrix choice (elemental Al) and the ''low shear'' consolidation methods utilized. This reinforcement effectiveness is further evidenced by elastic modulus measurements of the composites that are very close to the upper bound predictions of the rule of mixtures. The load partitioning measurements by neutron diffraction showed that composite samples made from GARS powders present significantly higher load transfer efficiency than the composites made from commercially atomized powders. Also, the composite samples made from GARS powders show a higher strengthening effect and ductility than the samples made from commercial purity powders. The higher load transfer efficiency and higher strength and ductility may result from an enhanced inter-particle bonding strength, promoted by the ''clean'' interfaces between particles. Further analysis of the load sharing measurements and the calculated values of the mismatch of coefficient of thermal expansion (CTE) and the geometrically necessary dislocation (GND) effects suggest that these strengthening mechanisms can be combined to predict accurately the strength of the composites.

  10. Resin Systems and Chemistry-Degradation Mechanisms and Durability in Long-Term Durability of Polymeric Matrix Composites. Chapter 1

    NASA Technical Reports Server (NTRS)

    Hinkley, Jeffrey A.; Connell, John W.

    2012-01-01

    In choosing a polymer-matrix composite material for a particular application, a number of factors need to be weighed. Among these are mechanical requirements, fabrication method (e.g. press-molding, resin infusion, filament winding, tape layup), and use conditions. Primary among the environmental exposures encountered in aerospace structures are moisture and elevated temperatures, but certain applications may require resistance to other fluids and solvents, alkaline agents, thermal cycling, radiation, or rapid, localized heating (for example, lightning strike). In this chapter, the main classes of polymer resin systems found in aerospace composites will be discussed. Within each class, their responses to environmental factors and the associated degradation mechanisms will be reviewed.

  11. SU-E-J-08: A Hybrid Three Dimensional Registration Framework for Image-Guided Accurate Radiotherapy System ARTS-IGRT

    SciTech Connect

    Wu, Q; Pei, X; Cao, R; Hu, L; Wu, Y

    2014-06-01

    Purpose: The purpose of this work was to develop a registration framework and method based on the software platform of ARTS-IGRT and implement in C++ based on ITK libraries to register CT images and CBCT images. ARTS-IGRT was a part of our self-developed accurate radiation planning system ARTS. Methods: Mutual information (MI) registration treated each voxel equally. Actually, different voxels even having same intensity should be treated differently in the registration procedure. According to their importance values calculated from self-information, a similarity measure was proposed which combined the spatial importance of a voxel with MI (S-MI). For lung registration, Firstly, a global alignment method was adopted to minimize the margin error and achieve the alignment of these two images on the whole. The result obtained at the low resolution level was then interpolated to become the initial conditions for the higher resolution computation. Secondly, a new similarity measurement S-MI was established to quantify how close the two input image volumes were to each other. Finally, Demons model was applied to compute the deformable map. Results: Registration tools were tested for head-neck and lung images and the average region was 128*128*49. The rigid registration took approximately 2 min and converged 10% faster than traditional MI algorithm, the accuracy reached 1mm for head-neck images. For lung images, the improved symmetric Demons registration process was completed in an average of 5 min using a 2.4GHz dual core CPU. Conclusion: A registration framework was developed to correct patient's setup according to register the planning CT volume data and the daily reconstructed 3D CBCT data. The experiments showed that the spatial MI algorithm can be adopted for head-neck images. The improved Demons deformable registration was more suitable to lung images, and rigid alignment should be applied before deformable registration to get more accurate result. Supported by

  12. The rigorous stochastic matrix multiplication scheme for the calculations of reduced equilibrium density matrices of open multilevel quantum systems

    SciTech Connect

    Chen, Xin

    2014-04-21

    Understanding the roles of the temporary and spatial structures of quantum functional noise in open multilevel quantum molecular systems attracts a lot of theoretical interests. I want to establish a rigorous and general framework for functional quantum noises from the constructive and computational perspectives, i.e., how to generate the random trajectories to reproduce the kernel and path ordering of the influence functional with effective Monte Carlo methods for arbitrary spectral densities. This construction approach aims to unify the existing stochastic models to rigorously describe the temporary and spatial structure of Gaussian quantum noises. In this paper, I review the Euclidean imaginary time influence functional and propose the stochastic matrix multiplication scheme to calculate reduced equilibrium density matrices (REDM). In addition, I review and discuss the Feynman-Vernon influence functional according to the Gaussian quadratic integral, particularly its imaginary part which is critical to the rigorous description of the quantum detailed balance. As a result, I establish the conditions under which the influence functional can be interpreted as the average of exponential functional operator over real-valued Gaussian processes for open multilevel quantum systems. I also show the difference between the local and nonlocal phonons within this framework. With the stochastic matrix multiplication scheme, I compare the normalized REDM with the Boltzmann equilibrium distribution for open multilevel quantum systems.

  13. Statistical Analysis of the Figure of Merit of a Two-Level Thermoelectric System: A Random Matrix Approach

    NASA Astrophysics Data System (ADS)

    Abbout, Adel; Ouerdane, Henni; Goupil, Christophe

    2016-09-01

    Using the tools of random matrix theory we develop a statistical analysis of the transport properties of thermoelectric low-dimensional systems made of two electron reservoirs set at different temperatures and chemical potentials, and connected through a low-density-of-states two-level quantum dot that acts as a conducting chaotic cavity. Our exact treatment of the chaotic behavior in such devices lies on the scattering matrix formalism and yields analytical expressions for the joint probability distribution functions of the Seebeck coefficient and the transmission profile, as well as the marginal distributions, at arbitrary Fermi energy. The scattering matrices belong to circular ensembles which we sample to numerically compute the transmission function, the Seebeck coefficient, and their relationship. The exact transport coefficients probability distributions are found to be highly non-Gaussian for small numbers of conduction modes, and the analytical and numerical results are in excellent agreement. The system performance is also studied, and we find that the optimum performance is obtained for half-transparent quantum dots; further, this optimum may be enhanced for systems with few conduction modes.

  14. Quantum propagation and confinement in 1D systems using the transfer-matrix method

    NASA Astrophysics Data System (ADS)

    Pujol, Olivier; Carles, Robert; Pérez, José-Philippe

    2014-05-01

    The aim of this article is to provide some Matlab scripts to the teaching community in quantum physics. The scripts are based on the transfer-matrix formalism and offer a very efficient and versatile tool to solve problems of a physical object (electron, proton, neutron, etc) with one-dimensional (1D) stationary potential energy. Resonant tunnelling through a multiple-barrier or confinement in wells of various shapes is particularly analysed. The results are quantitatively discussed with semiconductor heterostructures, harmonic and anharmonic molecular vibrations, or neutrons in a gravity field. Scripts and other examples (hydrogen-like ions and transmission by a smooth variation of potential energy) are available freely at http://www-loa.univ-lille1.fr/˜pujol in three languages: English, French and Spanish.

  15. Evaluating cell matrix mechanics using an integrated nonlinear optical tweezer-confocal imaging system

    NASA Astrophysics Data System (ADS)

    Peng, Berney; Alonzo, Carlo A. C.; Xia, Lawrence; Speroni, Lucia; Georgakoudi, Irene; Soto, Ana M.; Sonnenschein, Carlos; Cronin-Golomb, Mark

    2013-09-01

    Biomechanics plays a central role in breast epithelial morphogenesis. In this study we have used 3D cultures in which normal breast epithelial cells are able to organize into rounded acini and tubular ducts, the main structures found in the breast tissue. We have identified fiber organization as a main determinant of ductal organization. While bulk rheological properties of the matrix seem to play a negligible role in determining the proportion of acini versus ducts, local changes may be pivotal in shape determination. As such, the ability to make microscale rheology measurements coupled with simultaneous optical imaging in 3D cultures can be critical to assess the biomechanical factors underlying epithelial morphogenesis. This paper describes the inclusion of optical tweezers based microrheology in a microscope that had been designed for nonlinear optical imaging of collagen networks in ECM. We propose two microrheology methods and show preliminary results using a gelatin hydrogel and collagen/Matrigel 3D cultures containing mammary gland epithelial cells.

  16. Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies.

    PubMed

    Aleksovski, Aleksandar; Van Bockstal, Pieter-Jan; Roškar, Robert; Sovány, Tamás; Regdon, Géza; De Beer, Thomas; Vervaet, Chris; Dreu, Rok

    2016-06-10

    The aim of this study was to develop, evaluate and compare extended release mini-matrices based on metoprolol tartrate (MPT) and either glyceryl behenate (GB) or glyceryl palmitostearate (GPS). Mini-matrices were produced by three different techniques: hot melt extrusion, compression of melt granulates and prilling. Hot-melt extrusion and compression of granules obtained from melted material proved to be reliable, robust and reproducible techniques with aim of obtaining extended release matrices. Prilling tended to be susceptible to increased melt viscosity. Direct compression was not applicable for mini-matrix production due to poor powder flow. In general MPT release from all matrices was affected by its loading and the size of the units/particles. Processing of GB-MPT mixtures by different techniques did not lead to different drug release rates and patterns, while in case of GPS differently obtained matrices provided diverse MPT release outcomes. Matrices based on GB tended to have higher porosity compared to ones composed of GPS and thus most of the GB-based formulations showed faster drug delivery. FT-IR analysis revealed no interactions between primary components used for matrix production and Raman mapping outlined uniform MPT distribution throughout the units. DSC and X-ray studies revealed significant changes in the crystallinity of glycerides after storage under room conditions (GPS samples) and at increased temperature (GB and GPS samples), which was correlated to the changes seen in drug release rate and pattern after storage. Media composition in general tended to insignificantly affect GB matrices, while in case of GPS matrices increasing the pH and presence of biorelevant compounds induced faster drug release.

  17. Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies.

    PubMed

    Aleksovski, Aleksandar; Van Bockstal, Pieter-Jan; Roškar, Robert; Sovány, Tamás; Regdon, Géza; De Beer, Thomas; Vervaet, Chris; Dreu, Rok

    2016-06-10

    The aim of this study was to develop, evaluate and compare extended release mini-matrices based on metoprolol tartrate (MPT) and either glyceryl behenate (GB) or glyceryl palmitostearate (GPS). Mini-matrices were produced by three different techniques: hot melt extrusion, compression of melt granulates and prilling. Hot-melt extrusion and compression of granules obtained from melted material proved to be reliable, robust and reproducible techniques with aim of obtaining extended release matrices. Prilling tended to be susceptible to increased melt viscosity. Direct compression was not applicable for mini-matrix production due to poor powder flow. In general MPT release from all matrices was affected by its loading and the size of the units/particles. Processing of GB-MPT mixtures by different techniques did not lead to different drug release rates and patterns, while in case of GPS differently obtained matrices provided diverse MPT release outcomes. Matrices based on GB tended to have higher porosity compared to ones composed of GPS and thus most of the GB-based formulations showed faster drug delivery. FT-IR analysis revealed no interactions between primary components used for matrix production and Raman mapping outlined uniform MPT distribution throughout the units. DSC and X-ray studies revealed significant changes in the crystallinity of glycerides after storage under room conditions (GPS samples) and at increased temperature (GB and GPS samples), which was correlated to the changes seen in drug release rate and pattern after storage. Media composition in general tended to insignificantly affect GB matrices, while in case of GPS matrices increasing the pH and presence of biorelevant compounds induced faster drug release. PMID:26980237

  18. Creep Behavior of Hafnia and Ytterbium Silicate Environmental Barrier Coating Systems on SiC/SiC Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Zhu, Dongming; Fox, Dennis S.; Ghosn, Louis J.; Harder, Bryan

    2011-01-01

    Environmental barrier coatings will play a crucial role in future advanced gas turbine engines because of their ability to significantly extend the temperature capability and stability of SiC/SiC ceramic matrix composite (CMC) engine components, thus improving the engine performance. In order to develop high performance, robust coating systems for engine components, appropriate test approaches simulating operating temperature gradient and stress environments for evaluating the critical coating properties must be established. In this paper, thermal gradient mechanical testing approaches for evaluating creep and fatigue behavior of environmental barrier coated SiC/SiC CMC systems will be described. The creep and fatigue behavior of Hafnia and ytterbium silicate environmental barrier coatings on SiC/SiC CMC systems will be reported in simulated environmental exposure conditions. The coating failure mechanisms will also be discussed under the heat flux and stress conditions.

  19. Matrix effects in applying mono- and polyclonal ELISA systems to the analysis of weathered oils in contaminated soil.

    PubMed

    Pollard, S J T; Farmer, J G; Knight, D M; Young, P J

    2002-01-01

    Commercial mono- and polyclonal enzyme-linked immunosorbent assay (ELISA) systems were applied to the on-site analysis of weathered hydrocarbon-contaminated soils at a former integrated steelworks. Comparisons were made between concentrations of solvent extractable matter (SEM) determined gravimetrically by Soxhlet (dichloromethane) extraction and those estimated immunologically by ELISA determination over a concentration range of 2000-330,000 mg SEM/kg soil dry weight. Both ELISA systems tinder-reported for the more weathered soil samples. Results suggest this is due to matrix effects in the sample rather than any inherent bias in the ELISA systems and it is concluded that, for weathered hydrocarbons typical of steelworks and coke production sites, the use of ELISA requires careful consideration as a field technique. Consideration of the target analyte relative to the composition of the hydrocarbon waste encountered appears critical.

  20. A time convolution less density matrix approach to the nonlinear optical response of a coupled system-bath complex

    SciTech Connect

    Richter, Marten Knorr, Andreas

    2010-04-15

    Time convolution less density matrix theory (TCL) is a powerful and well established tool to investigate strong system-bath coupling for linear optical spectra. We show that TCL equations can be generalised to the nonlinear optical response up to a chosen order in the optical field. This goal is achieved via an time convolution less perturbation scheme for the reduced density matrices of the electronic system. In our approach, the most important results are the inclusion of a electron-phonon coupling non-diagonal in the electronic states and memory effects of the bath: First, the considered model system is introduced. Second, the time evolution of the statistical operator is expanded with respect to the external optical field. This expansion is the starting point to explain how a TCL theory can treat the response up to in a certain order in the external field. Third, new TCL equations, including bath memory effects, are derived and the problem of information loss in the reduced density matrix is analysed. For this purpose, new dimensions are added to the reduced statistical operator to compensate lack of information in comparison with the full statistical operator. The theory is benchmarked with a two level system and applied to a three level system including non-diagonal phonon coupling. In our analysis of pump-probe experiments, the bath memory is influenced by the system state occupied between pump and probe pulse. In particular, the memory of the bath influences the dephasing process of electronic coherences developing during the time interval between pump and probe pulses.

  1. Can the Dupuit-Thiem equation accurately describe the flow pattern induced by injection in a laboratory scale aquifer-well system?

    NASA Astrophysics Data System (ADS)

    Bonilla, Jose; Kalwa, Fritz; Händel, Falk; Binder, Martin; Stefan, Catalin

    2016-04-01

    The Dupuit-Thiem equation is normally used to assess flow towards a pumping well in unconfined aquifers under steady-state conditions. For the formulation of the equation it is assumed that flow is laminar, radial and horizontal towards the well. It is well known that these assumptions are not met in the vicinity of the well; some authors restrict the application of the equation only to a radius larger than 1.5-fold the aquifer thickness. In this study, the equation accuracy to predict the pressure head is evaluated as a simple and quick analytical method to describe the flow pattern for different injection rates in the LSAW. A laboratory scale aquifer-well system (LSAW) was implemented to study the aquifer recharge through wells. The LSAW consists of a 1.0 m-diameter tank with a height of 1.1 meters, filled with sand and a screened well in the center with a diameter of 0.025 m. A regulated outflow system establishes a controlled water level at the tank wall to simulate various aquifer thicknesses. The pressure head at the bottom of the tank along one axis can be measured to assess the flow profile every 0.1 m between the well and the tank wall. In order to evaluate the accuracy of the Dupuit-Thiem equation, a combination of different injection rates and aquifer thicknesses were simulated in the LSAW. Contrary to what was expected (significant differences between the measured and calculated pressure heads in the well), the absolute difference between the calculated and measured pressure head is less than 10%. Beside this, the highest differences are not observed in the well itself, but in the near proximity of it, at a radius of 0.1 m. The results further show that the difference between the calculated and measured pressure heads tends to decrease with higher flow rates. Despite its limitations (assumption of laminar and horizontal flow throughout the whole aquifer), the Dupuit-Thiem equation is considered to accurately represent the flow system in the LSAW.

  2. Accurate quantum chemical calculations

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Langhoff, Stephen R.; Taylor, Peter R.

    1989-01-01

    An important goal of quantum chemical calculations is to provide an understanding of chemical bonding and molecular electronic structure. A second goal, the prediction of energy differences to chemical accuracy, has been much harder to attain. First, the computational resources required to achieve such accuracy are very large, and second, it is not straightforward to demonstrate that an apparently accurate result, in terms of agreement with experiment, does not result from a cancellation of errors. Recent advances in electronic structure methodology, coupled with the power of vector supercomputers, have made it possible to solve a number of electronic structure problems exactly using the full configuration interaction (FCI) method within a subspace of the complete Hilbert space. These exact results can be used to benchmark approximate techniques that are applicable to a wider range of chemical and physical problems. The methodology of many-electron quantum chemistry is reviewed. Methods are considered in detail for performing FCI calculations. The application of FCI methods to several three-electron problems in molecular physics are discussed. A number of benchmark applications of FCI wave functions are described. Atomic basis sets and the development of improved methods for handling very large basis sets are discussed: these are then applied to a number of chemical and spectroscopic problems; to transition metals; and to problems involving potential energy surfaces. Although the experiences described give considerable grounds for optimism about the general ability to perform accurate calculations, there are several problems that have proved less tractable, at least with current computer resources, and these and possible solutions are discussed.

  3. Embryonic and postnatal development of the layer I-directed ("matrix") thalamocortical system in the rat.

    PubMed

    Galazo, Maria J; Martinez-Cerdeño, Verónica; Porrero, César; Clascá, Francisco

    2008-02-01

    Inputs to the layer I apical dendritic tufts of pyramidal cells are crucial in "top-down" interactions in the cerebral cortex. A large population of thalamocortical cells, the "matrix" (M-type) cells, provides a direct robust input to layer I that is anatomically and functionally different from the thalamocortical input to layer VI. The developmental timecourse of M-type axons is examined here in rats aged E (embryonic day) 16 to P (postnatal day) 30. Anterograde techniques were used to label axons arising from 2 thalamic nuclei mainly made up of M-type cells, the Posterior and the Ventromedial. The primary growth cones of M-type axons rapidly reached the subplate of dorsally situated cortical areas. After this, interstitial branches would sprout from these axons under more lateral cortical regions to invade the overlying cortical plate forming secondary arbors. Moreover, retrograde labeling of M-type cell somata in the thalamus after tracer deposits confined to layer I revealed that large numbers of axons from multiple thalamic nuclei had already converged in a given spot of layer I by P3. Because of early ingrowth in such large numbers, interactions of M-type axons may significantly influence the early development of cortical circuits.

  4. Ordering Unstructured Meshes for Sparse Matrix Computations on Leading Parallel Systems

    NASA Technical Reports Server (NTRS)

    Oliker, Leonid; Li, Xiaoye; Heber, Gerd; Biswas, Rupak

    2000-01-01

    The ability of computers to solve hitherto intractable problems and simulate complex processes using mathematical models makes them an indispensable part of modern science and engineering. Computer simulations of large-scale realistic applications usually require solving a set of non-linear partial differential equations (PDES) over a finite region. For example, one thrust area in the DOE Grand Challenge projects is to design future accelerators such as the SpaHation Neutron Source (SNS). Our colleagues at SLAC need to model complex RFQ cavities with large aspect ratios. Unstructured grids are currently used to resolve the small features in a large computational domain; dynamic mesh adaptation will be added in the future for additional efficiency. The PDEs for electromagnetics are discretized by the FEM method, which leads to a generalized eigenvalue problem Kx = AMx, where K and M are the stiffness and mass matrices, and are very sparse. In a typical cavity model, the number of degrees of freedom is about one million. For such large eigenproblems, direct solution techniques quickly reach the memory limits. Instead, the most widely-used methods are Krylov subspace methods, such as Lanczos or Jacobi-Davidson. In all the Krylov-based algorithms, sparse matrix-vector multiplication (SPMV) must be performed repeatedly. Therefore, the efficiency of SPMV usually determines the eigensolver speed. SPMV is also one of the most heavily used kernels in large-scale numerical simulations.

  5. Expert system training and control based on the fuzzy relation matrix

    NASA Technical Reports Server (NTRS)

    Ren, Jie; Sheridan, T. B.

    1991-01-01

    Fuzzy knowledge, that for which the terms of reference are not crisp but overlapped, seems to characterize human expertise. This can be shown from the fact that an experienced human operator can control some complex plants better than a computer can. Proposed here is fuzzy theory to build a fuzzy expert relation matrix (FERM) from given rules or/and examples, either in linguistic terms or in numerical values to mimic human processes of perception and decision making. The knowledge base is codified in terms of many implicit fuzzy rules. Fuzzy knowledge thus codified may also be compared with explicit rules specified by a human expert. It can also provide a basis for modeling the human operator and allow comparison of what a human operator says to what he does in practice. Two experiments were performed. In the first, control of liquid in a tank, demonstrates how the FERM knowledge base is elicited and trained. The other shows how to use a FERM, build up from linguistic rules, and to control an inverted pendulum without a dynamic model.

  6. Development Status and Performance Comparisons of Environmental Barrier Coating Systems for SiCSiC Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Zhu, Dongming; Harder, Bryan

    2016-01-01

    Environmental barrier coatings (EBC) and SiCSiC ceramic matrix composites (CMCs) will play a crucial role in future aircraft turbine engine systems, because of their ability to significantly increase engine operating temperatures, reduce engine weight and cooling requirements. This paper presents current NASA EBC-CMC development emphases including: the coating composition and processing improvements, laser high heat flux-thermal gradient thermo-mechanical fatigue - environmental testing methodology development, and property evaluations for next generation EBC-CMC systems. EBCs processed with various deposition techniques including Plasma Spray, Electron Beam - Physical Vapor Deposition, and Plasma Spray Physical Vapor Deposition (PS-PVD) will be particularly discussed. The testing results and demonstrations of advanced EBCs-CMCs in complex simulated engine thermal gradient cyclic fatigue, oxidizing-steam and CMAS environments will help provide insights into the coating development strategies to meet long-term engine component durability goals.

  7. Quantum information aspects on bulk and nano interacting Fermi system: A spin-space density matrix approach

    NASA Astrophysics Data System (ADS)

    Afzali, R.; Ebrahimian, N.; Eghbalifar, B.

    2016-10-01

    By approximating the energy gap, entering nano-size effect via gap fluctuation and calculating the Green's functions and the space-spin density matrix, the dependence of quantum correlation (entanglement, discord and tripartite entanglement) on the relative distance of two electron spins forming Cooper pairs, the energy gap and the length of bulk and nano interacting Fermi system (a nodal d-wave superconductor) is determined. In contrast to a s-wave superconductor, quantum correlation of the system is sensitive to the change of the gap magnitude and strongly depends on the length of the grain. Also, quantum discord oscillates. Furthermore, the entanglement length and the correlation length are investigated. Discord becomes zero at a characteristic length of the d-wave superconductor.

  8. Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains.

    PubMed

    Ishikawa, Fumihiro; Miyamoto, Kengo; Konno, Sho; Kasai, Shota; Kakeya, Hideaki

    2015-12-18

    A significant gap exists between protein engineering and enzymes used for the biosynthesis of natural products, largely because there is a paucity of strategies that rapidly detect active-site phenotypes of the enzymes with desired activities. Herein, we describe a proof-of-concept study of an enzyme-linked immunosorbent assay (ELISA) system for the adenylation (A) domains in nonribosomal peptide synthetases (NRPSs) using a combination of active site-directed probes coupled to a 5'-O-N-(aminoacyl)sulfamoyladenosine scaffold with a biotin functionality that immobilizes probe molecules onto a streptavidin-coated solid support. The recombinant NRPSs have a C-terminal His-tag motif that is targeted by an anti-6×His mouse antibody as the primary antibody and a horseradish peroxidase-linked goat antimouse antibody as the secondary antibody. These probes can selectively capture the cognate A domains by ligand-directed targeting. In addition, the ELISA technique detected A domains in the crude cell-free homogenates from the Escherichia coli expression systems. When coupled with a chromogenic substrate, the antibody-based ELISA technique can visualize probe-protein binding interactions, which provides accurate readouts of the A-domain functions in NRPS enzymes. To assess the ELISA-based engineering of the A domains of NRPSs, we reprogramed 2,3-dihydroxybenzoic acid (DHB)-activating enzyme EntE toward salicylic acid (Sal)-activating enzymes and investigated a correlation between binding properties for probe molecules and enzyme catalysts. We generated a mutant of EntE that displayed negligible loss in the kcat/Km value with the noncognate substrate Sal and a corresponding 48-fold decrease in the kcat/Km value with the cognate substrate DHB. The resulting 26-fold switch in substrate specificity was achieved by the replacement of a Ser residue in the active site of EntE with a Cys toward the nonribosomal codes of Sal-activating enzymes. Bringing a laboratory ELISA technique

  9. An in-line micro-pyrolysis system to remove contaminating organic species for precise and accurate water isotope analysis by spectroscopic techniques

    NASA Astrophysics Data System (ADS)

    Panetta, R. J.; Hsiao, G.

    2011-12-01

    Trace levels of organic contaminants such as short alcohols and terpenoids have been shown to cause spectral interference in water isotope analysis by spectroscopic techniques. The result is degraded precision and accuracy in both δD and δ18O for samples such as beverages, plant extracts or slightly contaminated waters. An initial approach offered by manufacturers is post-processing software that analyzes spectral features to identify and flag contaminated samples. However, it is impossible for this software to accurately reconstruct the water isotope signature, thus it is primarily a metric for data quality. Here, we describe a novel in-line pyrolysis system (Micro-Pyrolysis Technology, MPT) placed just prior to the inlet of a cavity ring-down spectroscopy (CRDS) analyzer that effectively removes interfering organic molecules without altering the isotope values of the water. Following injection of the water sample, N2 carrier gas passes the sample through a micro-pyrolysis tube heated with multiple high temperature elements in an oxygen-free environment. The temperature is maintained above the thermal decomposition threshold of most organic compounds (≤ 900 oC), but well below that of water (~2000 oC). The main products of the pyrolysis reaction are non-interfering species such as elemental carbon and H2 gas. To test the efficacy and applicability of the system, waters of known isotopic composition were spiked with varying amounts of common interfering alcohols (methanol, ethanol, propanol, hexanol, trans-2-hexenol, cis-3-hexanol up to 5 % v/v) and common soluble plant terpenoids (carveol, linalool, geraniol, prenol). Spiked samples with no treatment to remove the organics show strong interfering absorption peaks that adversely affect the δD and δ18O values. However, with the MPT in place, all interfering absorption peaks are removed and the water absorption spectrum is fully restored. As a consequence, the δD and δ18O values also return to their original

  10. A positioning model of a two CCD camera coordinate system with an alternate-four-matrix look-up table algorithm

    NASA Astrophysics Data System (ADS)

    Lin, Chern-Sheng; Chen, Chia-Tse; Wei, Tzu-Chi; Chen, Wei-Lung; Chang, Chia-Chang

    2010-12-01

    This study proposes a novel positioning model of a two CCD camera coordinate system with an alternate-four-matrix (AFM) look-up table (LUT) algorithm. Two CCD cameras are set on both sides of a large scale screen and used to aid the position measures of targets. The coordinate position of the object in a specified space can be obtained by using different viewing angles of the two cameras and the AFMLUT method. The right camera is in charge of detecting the intermediate block near the right side and the dead zone of the left camera, using the first and the second matrix LUTs. The left camera is in charge of detecting the other parts, using the third and the fourth matrix LUTs. The results indicate that this rapid mapping and four matrix memory allocation method has good accuracy (positioning error <2%) and stability when operating a human-machine interface system.

  11. Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia

    PubMed Central

    Witsch, Thilo J.; Turowski, Paweł; Sakkas, Elpidoforos; Niess, Gero; Becker, Simone; Herold, Susanne; Mayer, Konstantin; Vadász, István; Roberts, Jesse D.; Seeger, Werner

    2013-01-01

    Bronchopulmonary dysplasia (BPD) is a common and serious complication of premature birth, characterized by a pronounced arrest of alveolar development. The underlying pathophysiological mechanisms are poorly understood although perturbations to the maturation and remodeling of the extracellular matrix (ECM) are emerging as candidate disease pathomechanisms. In this study, the expression and regulation of three members of the lysyl hydroxylase family of ECM remodeling enzymes (Plod1, Plod2, and Plod3) in clinical BPD, as well as in an experimental animal model of BPD, were addressed. All three enzymes were localized to the septal walls in developing mouse lungs, with Plod1 also expressed in the vessel walls of the developing lung and Plod3 expressed uniquely at the base of developing septa. The expression of plod1, plod2, and plod3 was upregulated in the lungs of mouse pups exposed to 85% O2, an experimental animal model of BPD. Transforming growth factor (TGF)-β increased plod2 mRNA levels and activated the plod2 promoter in vitro in lung epithelial cells and in lung fibroblasts. Using in vivo neutralization of TGF-β signaling in the experimental animal model of BPD, TGF-β was identified as the regulator of aberrant plod2 expression. PLOD2 mRNA expression was also elevated in human neonates who died with BPD or at risk for BPD, compared with neonates matched for gestational age at birth or chronological age at death. These data point to potential roles for lysyl hydroxylases in normal lung development, as well as in perturbed late lung development associated with BPD. PMID:24285264

  12. Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Nocardia, Rhodococcus, Kocuria, Gordonia, Tsukamurella, and Listeria Species

    PubMed Central

    Lee, Tai-Fen; Du, Shin-Hei; Teng, Shih-Hua; Liao, Chun-Hsing; Sheng, Wang-Hui; Teng, Lee-Jene

    2014-01-01

    We evaluated whether the Bruker Biotyper matrix-associated laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) system provides accurate species-level identifications of 147 isolates of aerobically growing Gram-positive rods (GPRs). The bacterial isolates included Nocardia (n = 74), Listeria (n = 39), Kocuria (n = 15), Rhodococcus (n = 10), Gordonia (n = 7), and Tsukamurella (n = 2) species, which had all been identified by conventional methods, molecular methods, or both. In total, 89.7% of Listeria monocytogenes, 80% of Rhodococcus species, 26.7% of Kocuria species, and 14.9% of Nocardia species (n = 11, all N. nova and N. otitidiscaviarum) were correctly identified to the species level (score values, ≥2.0). A clustering analysis of spectra generated by the Bruker Biotyper identified six clusters of Nocardia species, i.e., cluster 1 (N. cyriacigeorgica), cluster 2 (N. brasiliensis), cluster 3 (N. farcinica), cluster 4 (N. puris), cluster 5 (N. asiatica), and cluster 6 (N. beijingensis), based on the six peaks generated by ClinProTools with the genetic algorithm, i.e., m/z 2,774.477 (cluster 1), m/z 5,389.792 (cluster 2), m/z 6,505.720 (cluster 3), m/z 5,428.795 (cluster 4), m/z 6,525.326 (cluster 5), and m/z 16,085.216 (cluster 6). Two clusters of L. monocytogenes spectra were also found according to the five peaks, i.e., m/z 5,594.85, m/z 6,184.39, and m/z 11,187.31, for cluster 1 (serotype 1/2a) and m/z 5,601.21 and m/z 11,199.33 for cluster 2 (serotypes 1/2b and 4b). The Bruker Biotyper system was unable to accurately identify Nocardia (except for N. nova and N. otitidiscaviarum), Tsukamurella, or Gordonia species. Continuous expansion of the MALDI-TOF MS databases to include more GPRs is necessary. PMID:24759706

  13. An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix.

    PubMed

    Kulp, Kristen S; Fortson, Susan L; Knize, Mark G; Felton, James S

    2003-12-01

    To understand the impact of variation in digestion parameters on the release of heterocyclic amines naturally formed during cooking, we developed and characterized a model system to assess the effect of amylase, pepsin, and pancreatin on digestion of well-done chicken. The amounts of MeIQx, DiMeIQx, IFP, and PhIP in the liquid portion of the digestate were compared to levels in the undigested meat to determine the percentage released (accessible fraction). Incubating the meat with amylase and pepsin did not change the accessibility of HAs when compared to incubation with water alone. In contrast, increasing amounts of pancreatin increased the accessibility up to 6.4-fold. Comparing the amounts of the HAs in the liquid to the solid fraction showed that there was more MeIQx, DiMeIQx, and IFP in the liquid fraction. In contrast, PhIP was equally divided between the solid and liquid fractions. For all four compounds, increasing the doneness of the meat decreased the amount of the compound accessible from the meat matrix. Our data suggest that bioaccessability of HAs may vary according to the polarity of the individual HAs and also may depend upon the doneness of the meat. These results may have important ramifications for human feeding studies, which assume that the total amount of each HA in the meat matrix is equally bioavailable.

  14. Quasi-disjoint pentadiagonal matrix systems for the parallelization of compact finite-difference schemes and filters

    NASA Astrophysics Data System (ADS)

    Kim, Jae Wook

    2013-05-01

    This paper proposes a novel systematic approach for the parallelization of pentadiagonal compact finite-difference schemes and filters based on domain decomposition. The proposed approach allows a pentadiagonal banded matrix system to be split into quasi-disjoint subsystems by using a linear-algebraic transformation technique. As a result the inversion of pentadiagonal matrices can be implemented within each subdomain in an independent manner subject to a conventional halo-exchange process. The proposed matrix transformation leads to new subdomain boundary (SB) compact schemes and filters that require three halo terms to exchange with neighboring subdomains. The internode communication overhead in the present approach is equivalent to that of standard explicit schemes and filters based on seven-point discretization stencils. The new SB compact schemes and filters demand additional arithmetic operations compared to the original serial ones. However, it is shown that the additional cost becomes sufficiently low by choosing optimal sizes of their discretization stencils. Compared to earlier published results, the proposed SB compact schemes and filters successfully reduce parallelization artifacts arising from subdomain boundaries to a level sufficiently negligible for sophisticated aeroacoustic simulations without degrading parallel efficiency. The overall performance and parallel efficiency of the proposed approach are demonstrated by stringent benchmark tests.

  15. Response calculations based on an independent particle system with the exact one-particle density matrix: Polarizabilities

    SciTech Connect

    Giesbertz, K. J. H.; Gritsenko, O. V.; Baerends, E. J.

    2014-05-14

    Recently, we have demonstrated that the problems finding a suitable adiabatic approximation in time-dependent one-body reduced density matrix functional theory can be remedied by introducing an additional degree of freedom to describe the system: the phase of the natural orbitals [K. J. H. Giesbertz, O. V. Gritsenko, and E. J. Baerends, Phys. Rev. Lett. 105, 013002 (2010); K. J. H. Giesbertz, O. V. Gritsenko, and E. J. Baerends, J. Chem. Phys. 133, 174119 (2010)]. In this article we will show in detail how the frequency-dependent response equations give the proper static limit (ω → 0), including the perturbation in the chemical potential, which is required in static response theory to ensure the correct number of particles. Additionally we show results for the polarizability for H{sub 2} and compare the performance of two different two-electron functionals: the phase-including Löwdin–Shull functional and the density matrix form of the Löwdin–Shull functional.

  16. A Comparison of Accuracy of Matrix Impression System with Putty Reline Technique and Multiple Mix Technique: An In Vitro Study

    PubMed Central

    Kumar, M Praveen; Patil, Suneel G; Dheeraj, Bhandari; Reddy, Keshav; Goel, Dinker; Krishna, Gopi

    2015-01-01

    Background: The difficulty in obtaining an acceptable impression increases exponentially as the number of abutments increases. Accuracy of the impression material and the use of a suitable impression technique are of utmost importance in the fabrication of a fixed partial denture. This study compared the accuracy of the matrix impression system with conventional putty reline and multiple mix technique for individual dies by comparing the inter-abutment distance in the casts obtained from the impressions. Materials and Methods: Three groups, 10 impressions each with three impression techniques (matrix impression system, putty reline technique and multiple mix technique) were made of a master die. Typodont teeth were embedded in a maxillary frasaco model base. The left first premolar was removed to create a three-unit fixed partial denture situation and the left canine and second premolar were prepared conservatively, and hatch marks were made on the abutment teeth. The final casts obtained from the impressions were examined under a profile projector and the inter-abutment distance was calculated for all the casts and compared. Results: The results from this study showed that in the mesiodistal dimensions the percentage deviation from master model in Group I was 0.1 and 0.2, in Group II was 0.9 and 0.3, and Group III was 1.6 and 1.5, respectively. In the labio-palatal dimensions the percentage deviation from master model in Group I was 0.01 and 0.4, Group II was 1.9 and 1.3, and Group III was 2.2 and 2.0, respectively. In the cervico-incisal dimensions the percentage deviation from the master model in Group I was 1.1 and 0.2, Group II was 3.9 and 1.7, and Group III was 1.9 and 3.0, respectively. In the inter-abutment dimension of dies, percentage deviation from master model in Group I was 0.1, Group II was 0.6, and Group III was 1.0. Conclusion: The matrix impression system showed more accuracy of reproduction for individual dies when compared with putty reline

  17. Anisotropic dielectric properties of two-dimensional matrix in pseudo-spin ferroelectric system

    NASA Astrophysics Data System (ADS)

    Kim, Se-Hun

    2016-10-01

    The anisotropic dielectric properties of a two-dimensional (2D) ferroelectric system were studied using the statistical calculation of the pseudo-spin Ising Hamiltonian model. It is necessary to delay the time for measurements of the observable and the independence of the new spin configuration under Monte Carlo sampling, in which the thermal equilibrium state depends on the temperature and size of the system. The autocorrelation time constants of the normalized relaxation function were determined by taking temperature and 2D lattice size into account. We discuss the dielectric constants of a two-dimensional ferroelectric system by using the Metropolis method in view of the Slater-Takagi defect energies.

  18. The usefulness of performance matrix tests in locomotor system evaluation of girls attending a ballet school - preliminary observation.

    PubMed

    Wójcik, Małgorzata; Siatkowski, Idzi

    2014-01-01

    [Purpose] Learning ballet is connected with continuous use of the locomotor system while subjecting it to high loads. Therefore, we conducted some research defining the appearance of weak links in the motor system, in order to eliminate the risk of injury. [Methods] Fifty-two female students of a ballet school were examined. To identify weak links, low-threshold Performance Matrix tests were performed. An analysis of weak link occurrence in the locomotor system was carried out, using two way analysis of variance ANOVA Tukey's HSD test, clustering methods and Principal Component Analysis (PCA). [Results] The average age of the subjects was 11.64±0.53 years (mean ± standard deviation), their average body height was 151.1±7.5 cm, their average body weight was 35.92±5.41 kg, and their average time of learning at ballet school was 2.17±0.65 years. We found that there were significant differences in weak links occurrence in the motor system of every girl examined. [Conclusions] Weak links were found in every location of the motor system. Our results show that the influence of weak link location is essentially different from their occurrence, and that learning ballet has a significantly different impact on the number of weak links in different locations. PMID:24567673

  19. The Usefulness of Performance Matrix Tests in Locomotor System Evaluation of Girls Attending a Ballet School — Preliminary Observation

    PubMed Central

    Wójcik, Małgorzata; Siatkowski, Idzi

    2014-01-01

    [Purpose] Learning ballet is connected with continuous use of the locomotor system while subjecting it to high loads. Therefore, we conducted some research defining the appearance of weak links in the motor system, in order to eliminate the risk of injury. [Methods] Fifty-two female students of a ballet school were examined. To identify weak links, low-threshold Performance Matrix tests were performed. An analysis of weak link occurrence in the locomotor system was carried out, using two way analysis of variance ANOVA Tukey’s HSD test, clustering methods and Principal Component Analysis (PCA). [Results] The average age of the subjects was 11.64±0.53 years (mean ± standard deviation), their average body height was 151.1±7.5 cm, their average body weight was 35.92±5.41 kg, and their average time of learning at ballet school was 2.17±0.65 years. We found that there were significant differences in weak links occurrence in the motor system of every girl examined. [Conclusions] Weak links were found in every location of the motor system. Our results show that the influence of weak link location is essentially different from their occurrence, and that learning ballet has a significantly different impact on the number of weak links in different locations. PMID:24567673

  20. POTENTIAL OF BIOLOGICAL MONITORING SYSTEMS TO DETECT TOXICITY IN A FINISHED MATRIX

    EPA Science Inventory

    Distribution systems of the U.S. are vulnerable to natural and anthropogenic factors affecting quality for use as drinking water. Important factors include physical parameters such as increased turbidity, ecological cycles such as algal blooms, and episodic contamination events ...

  1. Accurate Optical Reference Catalogs

    NASA Astrophysics Data System (ADS)

    Zacharias, N.

    2006-08-01

    Current and near future all-sky astrometric catalogs on the ICRF are reviewed with the emphasis on reference star data at optical wavelengths for user applications. The standard error of a Hipparcos Catalogue star position is now about 15 mas per coordinate. For the Tycho-2 data it is typically 20 to 100 mas, depending on magnitude. The USNO CCD Astrograph Catalog (UCAC) observing program was completed in 2004 and reductions toward the final UCAC3 release are in progress. This all-sky reference catalogue will have positional errors of 15 to 70 mas for stars in the 10 to 16 mag range, with a high degree of completeness. Proper motions for the about 60 million UCAC stars will be derived by combining UCAC astrometry with available early epoch data, including yet unpublished scans of the complete set of AGK2, Hamburg Zone astrograph and USNO Black Birch programs. Accurate positional and proper motion data are combined in the Naval Observatory Merged Astrometric Dataset (NOMAD) which includes Hipparcos, Tycho-2, UCAC2, USNO-B1, NPM+SPM plate scan data for astrometry, and is supplemented by multi-band optical photometry as well as 2MASS near infrared photometry. The Milli-Arcsecond Pathfinder Survey (MAPS) mission is currently being planned at USNO. This is a micro-satellite to obtain 1 mas positions, parallaxes, and 1 mas/yr proper motions for all bright stars down to about 15th magnitude. This program will be supplemented by a ground-based program to reach 18th magnitude on the 5 mas level.

  2. Matrix superpotentials

    NASA Astrophysics Data System (ADS)

    Nikitin, Anatoly G.; Karadzhov, Yuri

    2011-07-01

    We present a collection of matrix-valued shape invariant potentials which give rise to new exactly solvable problems of SUSY quantum mechanics. It includes all irreducible matrix superpotentials of the generic form W=kQ+\\frac{1}{k} R+P, where k is a variable parameter, Q is the unit matrix multiplied by a real-valued function of independent variable x, and P and R are the Hermitian matrices depending on x. In particular, we recover the Pron'ko-Stroganov 'matrix Coulomb potential' and all known scalar shape invariant potentials of SUSY quantum mechanics. In addition, five new shape invariant potentials are presented. Three of them admit a dual shape invariance, i.e. the related Hamiltonians can be factorized using two non-equivalent superpotentials. We find discrete spectrum and eigenvectors for the corresponding Schrödinger equations and prove that these eigenvectors are normalizable.

  3. Solving systems of linear equations by GPU-based matrix factorization in a Science Ground Segment

    NASA Astrophysics Data System (ADS)

    Legendre, Maxime; Schmidt, Albrecht; Moussaoui, Saïd; Lammers, Uwe

    2013-11-01

    Recently, Graphics Cards have been used to offload scientific computations from traditional CPUs for greater efficiency. This paper investigates the adaptation of a real-world linear system solver, which plays a central role in the data processing of the Science Ground Segment of ESA's astrometric Gaia mission. The paper quantifies the resource trade-offs between traditional CPU implementations and modern CUDA based GPU implementations. It also analyses the impact on the pipeline architecture and system development. The investigation starts from both a selected baseline algorithm with a reference implementation and a traditional linear system solver and then explores various modifications to control flow and data layout to achieve higher resource efficiency. It turns out that with the current state of the art, the modifications impact non-technical system attributes. For example, the control flow of the original modified Cholesky transform is modified so that locality of the code and verifiability deteriorate. The maintainability of the system is affected as well. On the system level, users will have to deal with more complex configuration control and testing procedures.

  4. Microgravity effects on water supply and substrate properties in porous matrix root support systems.

    PubMed

    Bingham, G E; Jones, S B; Or, D; Podolski, I G; Levinskikh, M A; Sytchov, V N; Ivanova, T; Kostov, P; Sapunova, S; Dandolov, I; Bubenheim, D B; Jahns, G

    2000-12-01

    The control of water content and water movement in granular substrate-based plant root systems in microgravity is a complex problem. Improper water and oxygen delivery to plant roots has delayed studies of the effects of microgravity on plant development and the use of plants in physical and mental life support systems. Our international effort (USA, Russia and Bulgaria) has upgraded the plant growth facilities on the Mir Orbital Station (OS) and used them to study the full life cycle of plants. The Bulgarian-Russian-developed Svet Space Greenhouse (SG) system was upgraded on the Mir OS in 1996. The US developed Gas Exchange Measurement System (GEMS) greatly extends the range of environmental parameters monitored. The Svet-GEMS complex was used to grow a fully developed wheat crop during 1996. The growth rate and development of these plants compared well with earth grown plants indicating that the root zone water and oxygen stresses that have limited plant development in previous long-duration experiments have been overcome. However, management of the root environment during this experiment involved several significant changes in control settings as the relationship between the water delivery system, water status sensors, and the substrate changed during the growth cycles.

  5. Microgravity effects on water supply and substrate properties in porous matrix root support systems

    NASA Technical Reports Server (NTRS)

    Bingham, G. E.; Jones, S. B.; Or, D.; Podolski, I. G.; Levinskikh, M. A.; Sytchov, V. N.; Ivanova, T.; Kostov, P.; Sapunova, S.; Dandolov, I.; Bubenheim, D. B.; Jahns, G.; Campbell, W. F. (Principal Investigator)

    2000-01-01

    The control of water content and water movement in granular substrate-based plant root systems in microgravity is a complex problem. Improper water and oxygen delivery to plant roots has delayed studies of the effects of microgravity on plant development and the use of plants in physical and mental life support systems. Our international effort (USA, Russia and Bulgaria) has upgraded the plant growth facilities on the Mir Orbital Station (OS) and used them to study the full life cycle of plants. The Bulgarian-Russian-developed Svet Space Greenhouse (SG) system was upgraded on the Mir OS in 1996. The US developed Gas Exchange Measurement System (GEMS) greatly extends the range of environmental parameters monitored. The Svet-GEMS complex was used to grow a fully developed wheat crop during 1996. The growth rate and development of these plants compared well with earth grown plants indicating that the root zone water and oxygen stresses that have limited plant development in previous long-duration experiments have been overcome. However, management of the root environment during this experiment involved several significant changes in control settings as the relationship between the water delivery system, water status sensors, and the substrate changed during the growth cycles. c 2001 Published by Elsevier Science Ltd. All rights reserved.

  6. Cross sections for n+{sup 14}N from an R-matrix analysis of the {sup 15}N system

    SciTech Connect

    Hale, G.M.; Young, P.G.; Chadwick, M.B.

    1994-06-01

    As part of the Hiroshima-Nagasaki Dose Reevaluation Program, a new evaluation of the neutron cross sections for {sup 14}N was made for ENDF/B-VI, based at energies below 2.5 MeV on a multichannel R-matrix analysis of reactions in the {sup 15}N system. The types of data used in the analysis, and the resulting cross sections and resonance structure for {sup 15}N are briefly described. The resonant features of the neutron cross sections were especially well determined by including precise, high-resolution neutron total cross section measurements from ORNL. While the new evaluated cross section appear to be significant improvements over the earlier ones, they still need to be tested more extensively against recent measurements of the differential elastic cross section from Oak Ridge.

  7. Artifact free reconstruction with the system matrix approach by overscanning the field-free-point trajectory in magnetic particle imaging

    NASA Astrophysics Data System (ADS)

    Weber, A.; Werner, F.; Weizenecker, J.; Buzug, T. M.; Knopp, T.

    2016-01-01

    Magnetic particle imaging is a tracer-based imaging method that utilizes the non-linear magnetization response of iron-oxide for determining their spatial distribution. The method is based on a sampling scheme where a sensitive spot is moved along a trajectory that captured a predefined field-of-view (FOV). However, particles outside the FOV also contribute to the measurement signal due to their rotation and the non-sharpness of the sensitive spot. In the present work we investigate artifacts that are induced by particles not covered by the FOV and show that the artifacts can be mitigated by using a system matrix that covers not only the region of interest but also a certain area around the FOV. The findings are especially relevant when using a multi-patch acquisition scheme where the boundaries of neighboring patches have to be handled.

  8. Systems and methods for reducing transient voltage spikes in matrix converters

    DOEpatents

    Kajouke, Lateef A.; Perisic, Milun; Ransom, Ray M.

    2013-06-11

    Systems and methods are provided for delivering energy using an energy conversion module that includes one or more switching elements. An exemplary electrical system comprises a DC interface, an AC interface, an isolation module, a first conversion module between the DC interface and the isolation module, and a second conversion module between the AC interface and the isolation module. A control module is configured to operate the first conversion module to provide an injection current to the second conversion module to reduce a magnitude of a current through a switching element of the second conversion module before opening the switching element.

  9. Solid-state active switch matrix for high energy, moderate power battery systems

    DOEpatents

    Deal, Larry; Paris, Peter; Ye, Changqing

    2016-06-07

    A battery management system employs electronic switches and capacitors. No traditional cell-balancing resistors are used. The BMS electronically switches individual cells into and out of a module of cells in order to use the maximum amount of energy available in each cell and to completely charge and discharge each cell without overcharging or under-discharging.

  10. A novel gastro-floating multiparticulate system for dipyridamole (DIP) based on a porous and low-density matrix core: in vitro and in vivo evaluation.

    PubMed

    Li, Zhao; Xu, Heming; Li, Shujuan; Li, Qijun; Zhang, Wenji; Ye, Tiantian; Yang, Xinggang; Pan, Weisan

    2014-01-30

    The study was aimed to develop a novel gastro-floating multiparticulate system based on a porous and low-density matrix core with excellent floatability. The gastro-floating pellets (GFP) were composed of a porous matrix core, a drug loaded layer (DIP and HPMC), a sub-coating layer (HPMC) and a retarding layer (Eudragit(®) NE 30D). The porous matrix cores were evaluated in specific. EC was chosen as the matrix membrane for its rigidity and minimal expansion to large extent. The porous matrix core was achieved by the complete release of the bulk water soluble excipient from the EC coated beads, and mannitol was selected as the optimal water soluble excipient. SEM photomicrographs confirmed the structure of porous matrix cores. The compositions of GFP were investigated and optimized by orthogonal array design. The optimized formulation could sustain the drug release for 12h and float on the dissolution medium for at least 12h without lag time to float. The pharmacokinetic study was conducted in beagle dogs, and the relative bioavailability of the test preparation was 193.11±3.43%. In conclusion, the novel gastro-floating pellets can be developed as a promising approach for the gastro-retentive drug delivery systems. PMID:24368104

  11. A novel gastro-floating multiparticulate system for dipyridamole (DIP) based on a porous and low-density matrix core: in vitro and in vivo evaluation.

    PubMed

    Li, Zhao; Xu, Heming; Li, Shujuan; Li, Qijun; Zhang, Wenji; Ye, Tiantian; Yang, Xinggang; Pan, Weisan

    2014-01-30

    The study was aimed to develop a novel gastro-floating multiparticulate system based on a porous and low-density matrix core with excellent floatability. The gastro-floating pellets (GFP) were composed of a porous matrix core, a drug loaded layer (DIP and HPMC), a sub-coating layer (HPMC) and a retarding layer (Eudragit(®) NE 30D). The porous matrix cores were evaluated in specific. EC was chosen as the matrix membrane for its rigidity and minimal expansion to large extent. The porous matrix core was achieved by the complete release of the bulk water soluble excipient from the EC coated beads, and mannitol was selected as the optimal water soluble excipient. SEM photomicrographs confirmed the structure of porous matrix cores. The compositions of GFP were investigated and optimized by orthogonal array design. The optimized formulation could sustain the drug release for 12h and float on the dissolution medium for at least 12h without lag time to float. The pharmacokinetic study was conducted in beagle dogs, and the relative bioavailability of the test preparation was 193.11±3.43%. In conclusion, the novel gastro-floating pellets can be developed as a promising approach for the gastro-retentive drug delivery systems.

  12. Optimizing identification of clinically relevant Gram-positive organisms by use of the Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometry system.

    PubMed

    McElvania Tekippe, Erin; Shuey, Sunni; Winkler, David W; Butler, Meghan A; Burnham, Carey-Ann D

    2013-05-01

    Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) can be used as a method for the rapid identification of microorganisms. This study evaluated the Bruker Biotyper (MALDI-TOF MS) system for the identification of clinically relevant Gram-positive organisms. We tested 239 aerobic Gram-positive organisms isolated from clinical specimens. We evaluated 4 direct-smear methods, including "heavy" (H) and "light" (L) smears, with and without a 1-μl direct formic acid (FA) overlay. The quality measure assigned to a MALDI-TOF MS identification is a numerical value or "score." We found that a heavy smear with a formic acid overlay (H+FA) produced optimal MALDI-TOF MS identification scores and the highest percentage of correctly identified organisms. Using a score of ≥2.0, we identified 183 of the 239 isolates (76.6%) to the genus level, and of the 181 isolates resolved to the species level, 141 isolates (77.9%) were correctly identified. To maximize the number of correct identifications while minimizing misidentifications, the data were analyzed using a score of ≥1.7 for genus- and species-level identification. Using this score, 220 of the 239 isolates (92.1%) were identified to the genus level, and of the 181 isolates resolved to the species level, 167 isolates (92.2%) could be assigned an accurate species identification. We also evaluated a subset of isolates for preanalytic factors that might influence MALDI-TOF MS identification. Frequent subcultures increased the number of unidentified isolates. Incubation temperatures and subcultures of the media did not alter the rate of identification. These data define the ideal bacterial preparation, identification score, and medium conditions for optimal identification of Gram-positive bacteria by use of MALDI-TOF MS.

  13. Stability, controllability and observability of linear matrix-second-order systems

    NASA Technical Reports Server (NTRS)

    Hughes, P. C.; Skelton, R. E.

    1979-01-01

    The stability, controllability and observability of lightly damped linear mechanical systems are considered and gyroscopic effects (e.g., control moment gyros) are also included. The structure of the equations is further specified to include both 'rigid' and 'elastic' modes, possibly coupled by gyroscopic terms. Stability and asymptotic stability results are summarized in two theorems. The special structure of the system equations permits a statement of the necessary and sufficient conditions for controllability and observability in terms of simple rank tests. Of great practical significance, the minimum number of actuators and sensors are among the necessary conditions derived. Natural definitions for modal controllability and observability are also evolved which give a direct indication of beneficial locations for actuators and sensors.

  14. Osmolarity affects matrix synthesis in the nucleus pulposus associated with the involvement of MAPK pathways: A study of ex vivo disc organ culture system.

    PubMed

    Li, Pei; Gan, Yibo; Xu, Yuan; Li, Songtao; Song, Lei; Li, Sukai; Li, Huijuan; Zhou, Qiang

    2016-06-01

    Matrix homeostasis within the nucleus pulposus (NP) is important for disc function. Unfortunately, the effects of osmolarity on NP matrix synthesis in a disc organ culture system and the underlying mechanisms are largely unknown. The present study was to investigate the effects of different osmolarity modes (constant and cyclic) and osmolarity levels (hypo-, iso-, and hyper-) on NP matrix synthesis using a disc organ culture system and determine whether ERK1/2 or p38MAPK pathway has a role in this process. Porcine discs were cultured for 7 days in various osmotic media, including constant hypo-, iso-, hyper-osmolarity (330, 430, and 550 mOsm/kg, respectively) and cyclic-osmolarity (430 mOsm/kg for 8 h, followed by 550 mOsm/kg for 16 h). The role of ERK1/2 and p38MAPK pathways were determined by their inhibitors U0126 and SB202190 respectively. The expression of SOX9 and downstream aggrecan and collagen II, biochemical content, and histology were used to assess NP matrix synthesis. The findings revealed that NP matrix synthesis was promoted in iso- and cyclic-osmolarity cultures compared to hypo- or hyper-osmolarity culture although the level of matrix synthesis in cyclic-osmolarity culture did not reach that in iso-osmolarity culture. Further analysis suggested that inhibition of the ERK1/2 or p38MAPK pathway in iso- and cyclic-osmolarity cultures reduced NP matrix production. Therefore, we concluded that the effects of osmolarity on NP matrix synthesis depend on osmolarity level (hypo-, iso-, or hyper-) and osmolarity mode (constant or cyclic), and the ERK1/2 and p38MAPK pathways may participate in this process. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1092-1100, 2016.

  15. Transient and stability analysis of large scale rotor-bearing system with strong nonlinear elements by the mode summation-transfer matrix method

    NASA Astrophysics Data System (ADS)

    Gu, Zhiping

    This paper extends Riccati transfer matrix method to the transient and stability analysis of large scale rotor-bearing systems with strong nonlinear elements, and proposes a mode summation-transfer matrix method, in which the field transfer matrix of a distributed mass uniform shaft segment is obtained with the aid of the idea of mode summation and Newmark beta formulation, and the Riccati transfer matrix method is adopted to stablize the boundary value problem of the nonlinear systems. In this investigation, the real nonlinearity of the strong nonlinear elements is considered, not linearized, and the advantages of the Riccati transfer matrix are retained. So, this method is especially applicable to analyze the transient response and stability of large-scale rotor-bear systems with strong nonlinear elements. One example, a single-spool rotating system with strong nonlinear elements, is given. The obtained results show that this method is superior to that of Gu and Chen (1990) in accuracy, stability, and economy.

  16. Durability and CMAS Resistance of Advanced Environmental Barrier Coatings Systems for SiC/SiC Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Zhu, Dongming

    2015-01-01

    Environmental barrier coatings (EBCs) and SiCSiC ceramic matrix composites (CMCs) systems will play a crucial role in next generation turbine engines for hot-section component applications because of their ability to significantly increase engine operating temperatures with improved efficiency, reduce engine weight and cooling requirements. This paper will emphasize advanced environmental barrier coating developments for SiCSiC turbine airfoil components, by using advanced coating compositions and processing, in conjunction with mechanical and environment testing and durability validations. The coating-CMC degradations and durability in the laboratory simulated engine fatigue-creep and complex operating environments are being addressed. The effects of Calcium-Magnesium-Alumino-Silicate (CMAS) from road sand or volcano-ash deposits on the degradation mechanisms of the environmental barrier coating systems will be discussed. The results help understand the advanced EBC-CMC system performance, aiming at the durability improvements of more robust, prime-reliant environmental barrier coatings for successful applications of the component technologies and lifing methodologies.

  17. Homolumo gap and matrix model

    SciTech Connect

    Andric, I.; Jonke, L.; Jurman, D.; Nielsen, H. B.

    2008-06-15

    We discuss a dynamical matrix model by which probability distribution is associated with Gaussian ensembles from random matrix theory. We interpret the matrix M as a Hamiltonian representing interaction of a bosonic system with a single fermion. We show that a system of second-quantized fermions influences the ground state of the whole system by producing a gap between the highest occupied eigenvalue and the lowest unoccupied eigenvalue.

  18. New York City Board of Education Division of School Safety: Incident Reporting System Needs To Be Strengthened To Ensure Accurate Reporting of School Safety Incidents, No. A-7-95.

    ERIC Educational Resources Information Center

    New York State Office of the Comptroller, Albany.

    The New York State Board of Education's Division of School Safety is responsible for maintaining a safe and secure environment to ensure that schools are free from disruption. This report presents findings of an audit that investigated whether the division's incident reporting system database accurately captured all school safety incidents that…

  19. Matrix product states for gauge field theories.

    PubMed

    Buyens, Boye; Haegeman, Jutho; Van Acoleyen, Karel; Verschelde, Henri; Verstraete, Frank

    2014-08-29

    The matrix product state formalism is used to simulate Hamiltonian lattice gauge theories. To this end, we define matrix product state manifolds which are manifestly gauge invariant. As an application, we study (1+1)-dimensional one flavor quantum electrodynamics, also known as the massive Schwinger model, and are able to determine very accurately the ground-state properties and elementary one-particle excitations in the continuum limit. In particular, a novel particle excitation in the form of a heavy vector boson is uncovered, compatible with the strong coupling expansion in the continuum. We also study full quantum nonequilibrium dynamics by simulating the real-time evolution of the system induced by a quench in the form of a uniform background electric field. PMID:25215973

  20. Ceramic Matrix Composite (CMC) Thermal Protection Systems (TPS) and Hot Structures for Hypersonic Vehicles

    NASA Technical Reports Server (NTRS)

    Glass, David E.

    2008-01-01

    Thermal protection systems (TPS) and hot structures are required for a range of hypersonic vehicles ranging from ballistic reentry to hypersonic cruise vehicles, both within Earth's atmosphere and non-Earth atmospheres. The focus of this paper is on air breathing hypersonic vehicles in the Earth's atmosphere. This includes single-stage to orbit (SSTO), two-stage to orbit (TSTO) accelerators, access to space vehicles, and hypersonic cruise vehicles. This paper will start out with a brief discussion of aerodynamic heating and thermal management techniques to address the high heating, followed by an overview of TPS for rocket-launched and air-breathing vehicles. The argument is presented that as we move from rocket-based vehicles to air-breathing vehicles, we need to move away from the insulated airplane approach used on the Space Shuttle Orbiter to a wide range of TPS and hot structure approaches. The primary portion of the paper will discuss issues and design options for CMC TPS and hot structure components, including leading edges, acreage TPS, and control surfaces. The current state-of-the-art will be briefly discussed for some of the components. The two primary technical challenges impacting the use of CMC TPS and hot structures for hypersonic vehicles are environmental durability and fabrication, and will be discussed briefly.

  1. Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix.

    PubMed

    Stout, David A; Toyjanova, Jennet; Franck, Christian

    2015-01-01

    The importance of cell migration can be seen through the development of human life. When cells migrate, they generate forces and transfer these forces to their surrounding area, leading to cell movement and migration. In order to understand the mechanisms that can alter and/or affect cell migration, one can study these forces. In theory, understanding the fundamental mechanisms and forces underlying cell migration holds the promise of effective approaches for treating diseases and promoting cellular transplantation. Unfortunately, modern chemotaxis chambers that have been developed are usually restricted to two dimensions (2D) and have complex diffusion gradients that make the experiment difficult to interpret. To this end, we have developed, and describe in this paper, a direct-viewing chamber for chemotaxis studies, which allows one to overcome modern chemotaxis chamber obstacles able to measure cell forces and specific concentration within the chamber in a 3D environment to study cell 3D migration. More compelling, this approach allows one to successfully model diffusion through 3D collagen matrices and calculate the coefficient of diffusion of a chemoattractant through multiple different concentrations of collagen, while keeping the system simple and user friendly for traction force microscopy (TFM) and digital volume correlation (DVC) analysis. PMID:26131645

  2. Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases.

    PubMed

    Happonen, Kaisa E; Heinegård, Dick; Saxne, Tore; Blom, Anna M

    2012-11-01

    Rheumatoid arthritis (RA) is a highly disabling disease affecting all structures of the joint. Understanding the pathology behind the development of RA is essential for developing targeted therapeutic strategies as well as for developing novel markers to predict disease onset. Several molecules normally hidden within the cartilage tissue are exposed to complement components in the synovial fluid upon cartilage breakdown. Some of these have been shown to activate complement and toll-like receptors, which may enhance an already existing inflammatory response, thereby worsening the course of disease. Other cartilage-resident molecules have in contrast shown to possess complement-inhibitory properties. Knowledge about mechanisms behind pathological complement activation in the joints will hopefully lead to methods which allow us to distinguish patients with pathological complement activation from those where other inflammatory pathways are predominant. This will help to elucidate which patients will benefit from complement inhibitory therapies, which are thought to aid a specific subset of patients or patients at a certain stage of disease. Future challenges are to target the complement inhibition specifically to the joints to minimize systemic complement blockade.

  3. Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix.

    PubMed

    Nagy, Nandor; Barad, Csilla; Graham, Hannah K; Hotta, Ryo; Cheng, Lily S; Fejszak, Nora; Goldstein, Allan M

    2016-01-15

    The enteric nervous system (ENS) develops from neural crest cells that migrate along the intestine, differentiate into neurons and glia, and pattern into two plexuses within the gut wall. Inductive interactions between epithelium and mesenchyme regulate gut development, but the influence of these interactions on ENS development is unknown. Epithelial-mesenchymal recombinations were constructed using avian hindgut mesenchyme and non-intestinal epithelium from the bursa of Fabricius. These recombinations led to abnormally large and ectopically positioned ganglia. We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial protein not expressed in the bursa, mediates this effect. Inhibition of Shh signaling, by addition of cyclopamine or a function-blocking antibody, resulted in large, ectopic ganglia adjacent to the epithelium. Shh overexpression, achieved in ovo using Shh-encoding retrovirus and in organ culture using recombinant protein, led to intestinal aganglionosis. Shh strongly induced the expression of versican and collagen type IX, whereas cyclopamine reduced expression of these chondroitin sulfate proteoglycans that are known to be inhibitory to neural crest cell migration. Shh also inhibited enteric neural crest-derived cell (ENCC) proliferation, promoted neuronal differentiation, and reduced expression of Gdnf, a key regulator of ENS formation. Ptc1 and Ptc2 were not expressed by ENCCs, and migration of isolated ENCCs was not inhibited by Shh protein. These results suggest that epithelial-derived Shh acts indirectly on the developing ENS by regulating the composition of the intestinal microenvironment. PMID:26674309

  4. Optical shutter switching matrix

    NASA Technical Reports Server (NTRS)

    Grove, Charles H.

    1991-01-01

    The interface switching systems are discussed which are related to those used in the Space Shuttle ground control system, transmission systems, communications systems, and airborne radar electronic countermeasure systems. The main goal is to identify a need that exists throughout the comprehensive information processing and communications disciplines supporting the Space Shuttle and Space Station programs, and introduce one viable approach to satisfy that need. The proposed device, described in NASA patent entitled 'Optical Shutter Switch Matrix', is discussed.

  5. Optimization of Multiple and Multipurpose Reservoir System Operations by Using Matrix Structure (Case Study: Karun and Dez Reservoir Dams)

    PubMed Central

    Othman, Faridah; Taghieh, Mahmood

    2016-01-01

    Optimal operation of water resources in multiple and multipurpose reservoirs is very complicated. This is because of the number of dams, each dam’s location (Series and parallel), conflict in objectives and the stochastic nature of the inflow of water in the system. In this paper, performance optimization of the system of Karun and Dez reservoir dams have been studied and investigated with the purposes of hydroelectric energy generation and providing water demand in 6 dams. On the Karun River, 5 dams have been built in the series arrangements, and the Dez dam has been built parallel to those 5 dams. One of the main achievements in this research is the implementation of the structure of production of hydroelectric energy as a function of matrix in MATLAB software. The results show that the role of objective function structure for generating hydroelectric energy in weighting method algorithm is more important than water supply. Nonetheless by implementing ε- constraint method algorithm, we can both increase hydroelectric power generation and supply around 85% of agricultural and industrial demands. PMID:27248152

  6. Optimization of Multiple and Multipurpose Reservoir System Operations by Using Matrix Structure (Case Study: Karun and Dez Reservoir Dams).

    PubMed

    Heydari, Mohammad; Othman, Faridah; Taghieh, Mahmood

    2016-01-01

    Optimal operation of water resources in multiple and multipurpose reservoirs is very complicated. This is because of the number of dams, each dam's location (Series and parallel), conflict in objectives and the stochastic nature of the inflow of water in the system. In this paper, performance optimization of the system of Karun and Dez reservoir dams have been studied and investigated with the purposes of hydroelectric energy generation and providing water demand in 6 dams. On the Karun River, 5 dams have been built in the series arrangements, and the Dez dam has been built parallel to those 5 dams. One of the main achievements in this research is the implementation of the structure of production of hydroelectric energy as a function of matrix in MATLAB software. The results show that the role of objective function structure for generating hydroelectric energy in weighting method algorithm is more important than water supply. Nonetheless by implementing ε- constraint method algorithm, we can both increase hydroelectric power generation and supply around 85% of agricultural and industrial demands.

  7. Sync Matrix

    2004-12-31

    Sync Matrix provides a graphic display of the relationships among all of the response activities of each jurisdiction. This is accomplished through software that organizes and displays the activities by jurisdiction, function, and time for easy review and analysis. The software can also integrate the displays of multiple jurisdictions to allow examination of the total response.

  8. Some properties of horn equation model of ultrasonic system vibration and of transfer matrix and equivalent circuit methods of its solution.

    PubMed

    Hornišová, K; Billik, P

    2014-01-01

    Traditional technique of horn equation solved by transfer matrices as a model of vibration of ultrasonic systems consisting of sectional transducer, horn and load is discussed. Expression of vibration modes as a ratio of solutions of two Schrödinger equations gives better insight to the structure of a transfer matrix and properties of amplitudes of displacement and strain, and enables more systematic search for analytic solutions. Incorrectness of impedance matrix method and of equivalent circuit method on one hand and correctness and advantages of transfer matrix method in avoiding numerical artifacts and revealing the real features of the model on the other hand are demonstrated on examples. Discontinuous dependence of the nth resonant value on parameters of ultrasonic system, recently described in Sturm-Liouville theory, and consequently, a jump from half-wave to full-wave mode, is observed in a transducer model.

  9. Efficient determination of the uncertainty for the optimization of SPECT system design: a subsampled fisher information matrix.

    PubMed

    Fuin, Niccolo; Pedemonte, Stefano; Arridge, Simon; Ourselin, Sebastien; Hutton, Brian F

    2014-03-01

    System designs in single photon emission tomography (SPECT) can be evaluated based on the fundamental trade-off between bias and variance that can be achieved in the reconstruction of emission tomograms. This trade off can be derived analytically using the Cramer-Rao type bounds, which imply the calculation and the inversion of the Fisher information matrix (FIM). The inverse of the FIM expresses the uncertainty associated to the tomogram, enabling the comparison of system designs. However, computing, storing and inverting the FIM is not practical with 3-D imaging systems. In order to tackle the problem of the computational load in calculating the inverse of the FIM, a method based on the calculation of the local impulse response and the variance, in a single point, from a single row of the FIM, has been previously proposed for system design. However this approximation (circulant approximation) does not capture the global interdependence between the variables in shift-variant systems such as SPECT, and cannot account e.g., for data truncation or missing data. Our new formulation relies on subsampling the FIM. The FIM is calculated over a subset of voxels arranged in a grid that covers the whole volume. Every element of the FIM at the grid points is calculated exactly, accounting for the acquisition geometry and for the object. This new formulation reduces the computational complexity in estimating the uncertainty, but nevertheless accounts for the global interdependence between the variables, enabling the exploration of design spaces hindered by the circulant approximation. The graphics processing unit accelerated implementation of the algorithm reduces further the computation times, making the algorithm a good candidate for real-time optimization of adaptive imaging systems. This paper describes the subsampled FIM formulation and implementation details. The advantages and limitations of the new approximation are explored, in comparison with the circulant

  10. Are conduits superconductor-like and supported by tetrahedra structure of hyaluronic matrix in living systems? New perspectives.

    PubMed

    Fromknecht, Rainer; Goncalves, Mario; Greten, Henry Johannes; Machado, Jorge

    2013-01-01

    All biological-medical treatments need a ground regulation in the intermeshed control loop system in animate matter. The focus of our contribution is to suggest a possible mechanism in this interconnected system that will work in order to supply/assist a higher ordered servo loop. Bonghan ducts indicate similarities to so-called meridians or conduits that are the central part in Chinese Medicine for the energy Qi. It is assumed that the nervous system demands a highly redundant and rapid communication system (RCS) probably established via the extracellular matrix (ECM) and triggered by a threshold value for the entire body. Metabolic processes could work in the picosecond's range while the nervous system is on the time scale at least one order of magnitude lower; probably most of them in the millisecond range. Long-range coherent electromagnetic phenomena and recent experiments indicate a structured superconducting-like system with the Josephson-effect behavior in biological systems. In the ECM are the components proteoglycans and glycosaminoglycans (PG/GAGs) and among them the ubiquitarian hyaluronic acid plays probably an important role and can behave as liquid crystals while the charge transport is performed via proton "jumping" in the proton-chains. Therefore, the water molecules have to be confident on a nanometer scale, lowering their energy states, and set up a phase transition with a rapid jumping of the protons through the water-carbon-chains. These partial chains could probably be modeled by tiny pyramids of the atoms. We propose that in order to set up those long-range coherent effects, a vortex is created. By doing Qi Gong, an energetic vortex through the body is established and the entire body can be modeled by two-base plane-faced pyramids acting as a tunable cavity resonator obeying electrodynamics laws. Therefore, the phenomenon's of pyramids should be considered in animate and inanimate matter in order to achieve long-range coherent effects, which

  11. "EWS Matrix" and "EWG Matrix": "De-sign for All" tools referred to the development of a enabling communication system for public spaces.

    PubMed

    Di Bucchianico, Giuseppe; Camplone, Stefania; Picciani, Stefano; Vallese, Valeria

    2012-01-01

    The widespread sense of spatial disorientation that can be experienced in many public places (buildings and open spaces),generally depends on a design approach that doesn't take into account both the "communication skills" of the different parts of the spatial organization, both the variability of people and their ways of interacting with environments, orienteering themselves. Nevertheless, "not find the way" often has some obvious practical costs (loss of time, failure to achieve a target) and some more intangible, but no less important, emotional costs. That's why the design of signage systems must take into account both the specificities of places and the extreme variability of its users. The paper presents the results of a study on this specific issue. In particular, the study focuses on the description of some tools useful for the analysis and design of a signage system that is truly "for All".

  12. Spacecraft IF switch matrix for wideband service applications in 30/20 GHz communications satellite systems: Proof-of-concept model, executive summary

    NASA Technical Reports Server (NTRS)

    Ho, P. T.; Coban, E.; Pelose, J.

    1983-01-01

    The design and development of a unique coupler crossbar 20 x 20 microwave switch matrix are described. The test results of the proof of concept model that meets the requirements for a high speed satellite switched, time division multiple access (SS-TDMA) system are presented.

  13. Influence of baking time and matrix effects on the detection of milk allergens in cookie model food system by ELISA.

    PubMed

    Monaci, Linda; Brohée, Marcel; Tregoat, Virginie; van Hengel, Arjon

    2011-07-15

    Milk allergens are common allergens occurring in foods, therefore raising concern in allergic consumers. Enzyme-linked immunosorbent assay (ELISA) is, to date, the method of choice for the detection of food allergens by the food industry although, the performance of ELISA might be compromised when severe food processing techniques are applied to allergen-containing foods. In this paper we investigated the influence of baking time on the detection of milk allergens by using commercial ELISA kits. Baked cookies were chosen as a model food system and experiments were set up to study the impact of spiking a matrix food either before, or after the baking process. Results revealed clear analytical differences between both spiking methods, which stress the importance of choosing appropriate spiking methodologies for method validation purposes. Finally, since the narrow dynamic range of quantification of ELISA implies that dilution of samples is required, the impact of sample dilution on the quantitative results was investigated. All parameters investigated were shown to impact milk allergen detection by means of ELISA.

  14. Aerothermoelastic response analysis for C/SiC panel of ceramic matrix composite shingle thermal protection system

    NASA Astrophysics Data System (ADS)

    Huo, Lin; Cheng, Xing-Hua; Yang, Tao

    2015-05-01

    This paper presents a study of aerothermoelastic response of a C/SiC panel, which is a primary structure for ceramic matrix composite shingle thermal protection system for hypersonic vehicles. It is based on a three dimensional thermal protection shingle panel on a quasi-waverider vehicle model. Firstly, the Thin Shock Layer and piston theory are adopted to compute the aerodynamic pressure of rigid body and deformable body, and a series of engineering methods are used to compute the aerodynamic heating. Then an aerothermoelastic loosely-coupled time marching strategy and self-adapting aerodynamic heating time step are developed to analyze the aerothermoelastic response of the panel, with an aerodynamic heating and temperature field coupling parameter selection method being adopted to increase the efficiency. Finally, a few revealing conclusions are reached by analyzing how coupling at different degrees influences the quasi-static aerothermoelastic response of the panel and how aerodynamic pressure of rigid body time step influences the quasi-static aerothermoelastic response on a glide trajectory.

  15. QUANTIFYING LOAD-INDUCED SOLUTE TRANSPORT AND SOLUTE-MATRIX INTERACTIONS WITHIN THE OSTEOCYTE LACUNAR-CANALICULAR SYSTEM

    PubMed Central

    Wang, Bin; Zhou, Xiaozhou; Price, Christopher; Li, Wen; Pan, Jun; Wang, Liyun

    2012-01-01

    Osteocytes, the most abundant cells in bone, are critical in maintaining tissue homeostasis and orchestrating bone’s mechanical adaptation. Osteocytes depend upon load-induced convection within the lacunar-canalicular system (LCS) to maintain viability and to sense their mechanical environment. Using the fluorescence recovery after photobleaching (FRAP) imaging approach, we previously quantified the convection of a small tracer (sodium fluorescein, 376Da) in the murine tibial LCS for an intermittent cyclic loading (Price et al., 2011. JBMR 26:277-85). In the present study we first expanded the investigation of solute transport using a larger tracer (parvalbumin, 12.3kDa), which is comparable in size to some signaling proteins secreted by osteocytes. Murine tibiae were subjected to sequential FRAP tests under rest-inserted cyclic loading while the loading magnitude (0, 2.8, or 4.8N) and frequency (0.5, 1, or 2 Hz) were varied. The characteristic transport rate k and the transport enhancement relative to diffusion (k/k0) were measured under each loading condition, from which the peak solute velocity in the LCS was derived using our LCS transport model. Both the transport enhancement and solute velocity increased with loading magnitude and decreased with loading frequency. Furthermore, the solute-matrix interactions, quantified in terms of the reflection coefficient through the osteocytic pericellular matrix (PCM), were measured and theoretically modeled. The reflection coefficient of parvalbumin (σ=0.084) was derived from the differential fluid and solute velocities within loaded bone. Using a newly developed PCM sieving model, the PCM’s fiber configurations accounting for the measured interactions were obtained for the first time. The present study provided not only new data on the micro-fluidic environment experienced by osteocytes in situ, but also a powerful quantitative tool for future study of the PCM, the critical interface that controls both outside

  16. The Effect of Nanosized Pb Liquid Phase on the Damping Behavior in Aluminum Matrix Composite Based on the 2024Al-BaPbO3 System

    NASA Astrophysics Data System (ADS)

    Fan, G. H.; Geng, L.; Wu, H.; Zheng, Z. Z.; Meng, Q. C.

    2016-03-01

    An aluminum matrix composite containing nanosized Pb particles was fabricated by a powder metallurgy technique based on the 2024Al-BaPbO3 system. The composite exhibited a high and broad damping peak at the melting temperature range of nanosized Pb particles. The increase in value and breadth of the damping peak was attributed to the dislocation damping of the interfacial matrix close to the nanosized Pb liquid phase. The damping peak is expected to be enhanced by further refining the Pb particle size.

  17. [THE COMPARATIVE ANALYSIS OF LEVEL OF OLIGOMERIC MATRIX PROTEIN OF CARTILAGE IN BLOOD SERUM OF PATIENTS WITH DISEASES OF MUSCULO-SKELETAL SYSTEM].

    PubMed

    Starodubtseva, L A; Vasilieva, L V

    2016-02-01

    The osteoarthritis and rheumatoid arthritis are considered as the most prevalent diseases in the structure of diseases of musculoskeletal system. The higher social significance of these nosologies dictates necessity of searching reliable cartilage biomarkers having diagnostic validity both in discerning degenerative alterations at early stage of disease of joints and in monitoring of treatment effectiveness. The content of oligomeric matrix protein of cartilage using ELISA was evaluated in blood serum ofpatients with secondary osteoarthritis under rheumatoid arthritis (n=248). The comparison of derived results was carried out using control groups. Within the framework of study relationship was evaluated between level of oligomeric matrix protein of cartilage in patients with secondary osteoarthritis under rheumatoid arthritis with values offunctional KOOS index. The analysis of derived results established trend to increasing of level of oligomeric matrix protein of cartilage in blood serum ofpatients with secondary osteoarthritis under rheumatoid arthritis as compared with control groups. The moderate correlation interdependence between cartilage biomarker and KOOS index.

  18. Effects of extracellular matrix proteins on macrophage differentiation, growth, and function: comparison of liquid and agar culture systems

    NASA Technical Reports Server (NTRS)

    Armstrong, J. W.; Chapes, S. K.; Spooner, B. S. (Principal Investigator)

    1994-01-01

    Both spaceflight and skeletal unloading suppress the haematopoietic differentiation of macrophages (Sonnenfeld et al., Aviat. Space Environ. Med., 61:648-653, 1990; Armstrong et al., J. Appl. Physiol., 75:2734-2739, 1993). The mechanism behind this reduction in haematopoiesis has yet to be elucidated. However, changes in bone marrow extracellular matrix (ECM) may be involved. To further understand the role of ECM products in macrophage differentiation, we have performed experiments evaluating the effects of fibronectin, laminin, collagen type I, and collagen type IV on macrophage development and function. Bone marrow-derived macrophages cultured on four different ECM substrates in liquid culture medium showed less growth than those cultured on plastic. Significant morphological differences were seen on each of the substrates used. Phenotypically and functionally, as measured by class II major histocompatibility molecule (MHCII) expression, MAC-2 expression, and the secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), these macrophages were similar. In contrast, bone marrow-derived macrophages cultured in suspension, using agar, showed no difference in growth when exposed to ECM proteins. However, IL-6 and TNF-alpha secretion was affected by fibronectin, laminin, collagen type I, and collagen type IV in a concentration-dependent manner. We conclude that the ECM products fibronectin, laminin, collagen type I, and collagen type IV have profound effects on macrophage development and function. Additionally, we suggest that an ECM-supplemented agar culture system provides an environment more analogous to in vivo bone marrow than does a traditional liquid culture system.

  19. Artificial extracellular matrix proteins containing phenylalanine analogues biosynthesized in bacteria using T7 expression system and the PEGylation.

    PubMed

    Takasu, Akinori; Kondo, Shiori; Ito, Akihiro; Furukawa, Yuya; Higuchi, Masahiro; Kinoshita, Takatoshi; Kwon, Inchan

    2011-10-10

    In vivo incorporation of phenylalanine (Phe) analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished using a bacterial expression host that harbors the mutant phenylalanyl-tRNA synthetase (PheRS) with an enlarged binding pocket. Although the Ala294Gly/Thr251Gly mutant PheRS (PheRS**) under the control of T5 promoter allows incorporation of some Phe analogues into a protein, the T5 system is not suitable for material science studies because the amount of materials produced is not sufficient due to the moderate strength of the T5 promoter. This limitation can be overcome by using a pair of T7 promoter and T7 RNA polymerase instead. In the T7 expression system, it is difficult, however, to achieve a high incorporation level of Phe analogues, due to competition of Phe analogues for incorporation with the residual Phe that is required for synthesis of active T7 RNA polymerase. In this study, we prepared the PheRS** under T7 promoter and optimized culture condition to improve both the incorporation level of recombinant aECM protein and the incorporation level of Phe analogues. Incorporation and expression levels tend to increase in the case of p-azidophenylalanine, p-iodophenylalanine, and p-acetylphenylalanine. We evaluated the lower critical transition temperature, which is dependent on the incorporation ratio and the turbidity decreased when the incorporation level increased. Circular dichromism measurement indicated that this tendency is based on conformational change from random coil to β-turn structure. We demonstrated that polyethylene glycol (PEG) can be conjugated at reaction site of Phe analogues incorporated. We also demonstrated that the increased hydrophilicity of elastin-like sequences in the aECM-CS5-ELF made by PEG conjugation could suppress nonspecific adhesion of human umbilical vein endothelial cells (HUVEC).

  20. Immunohistochemical Expression of Matrix Metalloproteinase-7 in Human Colorectal Adenomas Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study

    PubMed Central

    Qasim, Ban J.; Ali, Hussam H.; Hussein, Alaa G.

    2013-01-01

    Background/Aim: To evaluate the immunohistochemical expression of matrix metalloproteinase-7 (MMP-7) in colorectal adenomas, and to correlate this expression with different clinicopathological parameters. Patients and Methods: The study was retrospectively designed. Thirty three paraffin blocks from patients with colorectal adenoma and 20 samples of non-tumerous colonic tissue taken as control group were included in the study. MMP-7 expression was assessed by immunohistochemistry method. The scoring of immunohistochemical staining was conducted utilizing a specified automated cellular image analysis system (Digimizer). Results: The frequency of positive immunohistochemical expression of MMP-7 was significantly higher in adenoma than control group (45.45% versus 10%) (P value < 0.001). Strong MMP-7 staining was mainly seen in adenoma cases (30.30%) in comparison with control (0%) the difference is significant (P < 0.001). The three digital parameters of MMP-7 immunohistochemical expression (Area (A), Number of objects (N), and intensity (I)) were significantly higher in adenoma than control. Mean (A and I) of MMP-7 showed a significant correlation with large sized adenoma (≥ 1cm) (P < 0.05), also a significant positive correlation of the three digital parameters (A, N, and I) of MMP-7 expression with villous configuration and severe dysplasia in colorectal adenoma had been identified (P < 0.05). Conclusion: MMP-7 plays an important role in the growth and malignant conversion of colorectal adenomas as it is more likely to be expressed in advanced colorectal adenomatous polyps with large size, severe dysplasia and villous histology. The use of automated cellular image analysis system (Digmizer) to quantify immunohistochemical staining yields more consistent assay results, converts semi-quantitative assay to a truly quantitative assay, and improves assay objectivity and reproducibility. PMID:23319034

  1. A volume of intersection approach for on-the-fly system matrix calculation in 3D PET image reconstruction

    NASA Astrophysics Data System (ADS)

    Lougovski, A.; Hofheinz, F.; Maus, J.; Schramm, G.; Will, E.; van den Hoff, J.

    2014-02-01

    The aim of this study is the evaluation of on-the-fly volume of intersection computation for system’s geometry modelling in 3D PET image reconstruction. For this purpose we propose a simple geometrical model in which the cubic image voxels on the given Cartesian grid are approximated with spheres and the rectangular tubes of response (ToRs) are approximated with cylinders. The model was integrated into a fully 3D list-mode PET reconstruction for performance evaluation. In our model the volume of intersection between a voxel and the ToR is only a function of the impact parameter (the distance between voxel centre to ToR axis) but is independent of the relative orientation of voxel and ToR. This substantially reduces the computational complexity of the system matrix calculation. Based on phantom measurements it was determined that adjusting the diameters of the spherical voxel size and the ToR in such a way that the actual voxel and ToR volumes are conserved leads to the best compromise between high spatial resolution, low noise, and suppression of Gibbs artefacts in the reconstructed images. Phantom as well as clinical datasets from two different PET systems (Siemens ECAT HR+ and Philips Ingenuity-TF PET/MR) were processed using the developed and the respective vendor-provided (line of intersection related) reconstruction algorithms. A comparison of the reconstructed images demonstrated very good performance of the new approach. The evaluation showed the respective vendor-provided reconstruction algorithms to possess 34-41% lower resolution compared to the developed one while exhibiting comparable noise levels. Contrary to explicit point spread function modelling our model has a simple straight-forward implementation and it should be easy to integrate into existing reconstruction software, making it competitive to other existing resolution recovery techniques.

  2. Efficient fully 3D list-mode TOF PET image reconstruction using a factorized system matrix with an image domain resolution model

    PubMed Central

    Zhou, Jian; Qi, Jinyi

    2014-01-01

    A factorized system matrix utilizing an image domain resolution model is attractive in fully 3D TOF PET image reconstruction using list-mode data. In this paper, we study a factored model based on sparse matrix factorization that is comprised primarily of a simplified geometrical projection matrix and an image blurring matrix. Beside the commonly-used Siddon's raytracer, we propose another more simplified geometrical projector based on the Bresenham's raytracer which further reduces the computational cost. We discuss in general how to obtain an image blurring matrix associated with a geometrical projector, and provide theoretical analysis that can be used to inspect the efficiency in model factorization. In simulation studies, we investigate the performance of the proposed sparse factorization model in terms of spatial resolution, noise properties and computational cost. The quantitative results reveal that the factorization model can be as efficient as a nonfactored model such as the analytical model while its computational cost can be much lower. In addition we conduct Monte Carlo simulations to identify the conditions under which the image resolution model can become more efficient in terms of image contrast recovery. We verify our observations using the provided theoretical analysis. The result offers a general guide to achieve optimal reconstruction performance based on a sparse factorization model with an only image domain resolution model. PMID:24434568

  3. Efficient fully 3D list-mode TOF PET image reconstruction using a factorized system matrix with an image domain resolution model

    NASA Astrophysics Data System (ADS)

    Zhou, Jian; Qi, Jinyi

    2014-02-01

    A factorized system matrix utilizing an image domain resolution model is attractive in fully 3D time-of-flight PET image reconstruction using list-mode data. In this paper, we study a factored model based on sparse matrix factorization that is comprised primarily of a simplified geometrical projection matrix and an image blurring matrix. Beside the commonly-used Siddon’s ray-tracer, we propose another more simplified geometrical projector based on the Bresenham’s ray-tracer which further reduces the computational cost. We discuss in general how to obtain an image blurring matrix associated with a geometrical projector, and provide theoretical analysis that can be used to inspect the efficiency in model factorization. In simulation studies, we investigate the performance of the proposed sparse factorization model in terms of spatial resolution, noise properties and computational cost. The quantitative results reveal that the factorization model can be as efficient as a non-factored model, while its computational cost can be much lower. In addition we conduct Monte Carlo simulations to identify the conditions under which the image resolution model can become more efficient in terms of image contrast recovery. We verify our observations using the provided theoretical analysis. The result offers a general guide to achieve the optimal reconstruction performance based on a sparse factorization model with an image domain resolution model.

  4. A Quasiclassical Study of the F((2)P) + CHD3 (ν1 = 0,1) Reactive System on an Accurate Potential Energy Surface.

    PubMed

    Palma, Juliana; Manthe, Uwe

    2015-12-17

    Quasiclassical trajectories (QCT) have been employed to elucidate the effect of exciting the C-H bond in F + CHD3 collisions. The calculations were performed on a new potential energy surface that accurately describes the van der Waals complexes in the entrance channel of the reaction. It was found that exciting the C-H bond significantly enhances the yield of HF + CD3, whereas it has a minor effect on the production of DF + CHD2. Therefore, the net effect is that the total reactivity increases upon excitation. This result strongly contradicts recent experimental findings. Significant differences in regard to the yield of each product channel were also found between QCT results calculated with the new surface and those obtained with the surface previously developed by Czakó et al. This shows that relatively small variations in the topography of the entrance channel can result in huge discrepancies in the predicted DF/HF branching ratio. However, in regard to other attributes of the reaction, the agreement between QCT results computed with different surfaces, and between them and experimental results, is good. For the F + CHD3 → HF + CD3 reaction, at a collisional energy of 9.0 kcal/mol, experiments and QCT calculations agree, indicating that the extra energy deposited in the C-H bond is channelled into the HF product. In addition, the angular distribution of CD3 is backward oriented and is not sensitive to the excitation of the C-H bond. PMID:26270126

  5. Cost reduction and minimization of land based on an accurate determination of fault current distribution in shield wires and grounding systems

    SciTech Connect

    Daily, W.K. ); Dawalibi, F. )

    1993-01-01

    Careful analysis of Fault Current Distribution in neutral metallic paths, Power System Protection requirements and Ground Potential Rise (GPR) evaluations were carried out at FPL's Lauderdale Power Plant and associated switchyard. These studies resulted in substantial cost savings and land utilization minimization for the power system expansions at Lauderdale Plant by confirming that the in-situ expansion and reconfiguration aimed at constructing two electrically independent substations sharing the same site and grounding system is a sound economical alternative to the construction of a new substation and associated significant site preparation and construction costs. This paper describes the methodology used to conduct this study.

  6. Molecular host-guest energy-transfer system with an ultralow amplified spontaneous emission threshold employing an ambipolar semiconducting host matrix.

    PubMed

    Toffanin, Stefano; Capelli, Raffaella; Hwu, Tsyr-Yuan; Wong, Ken-Tsung; Plötzing, Tobias; Först, Michael; Muccini, Michele

    2010-01-14

    We report on the characteristics of a host-guest lasing system obtained by coevaporation of an oligo(9,9-diarylfluorene) derivative named T3 with the red-emitter 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran dye (DCM). We demonstrate that the ambipolar semiconductor T3 can be implemented as an active matrix in the realization of a host-guest system in which an efficient energy transfer takes place from the T3 matrix to the lasing DCM molecules. We performed a detailed spectroscopic study on the system by systematically varying the DCM concentration in the T3 matrix. Measurements of steady-state photoluminescence (PL), PL quantum yield (PLQY), time-resolved picosecond PL, and amplified spontaneous emission (ASE) threshold are used to optimize the acceptor concentration at which the ASE from DCM molecules takes place with the lowest threshold. The sample with a DCM relative deposition ratio of 2% shows an ASE threshold as low as 0.6 kW/cm(2) and a net optical gain measured by femtosecond time-resolved pump-and-probe spectroscopy as high as 77 cm(-1). The reference model system Alq(3):DCM sample measured in exactly the same experimental conditions presents an one-order-of-magnitude higher ASE threshold. The ASE threshold of T3:DCM is the lowest reported to date for a molecular host-guest energy-transfer system, which makes the investigated blend an appealing system for use as an active layer in lasing devices. In particular, the ambipolar charge transport properties of the T3 matrix and its field-effect characteristics make the host-guest system presented here an ideal candidate for the realization of electrically pumped organic lasers.

  7. MALDI-TOF MS is more accurate than VITEK II ANC card and API Rapid ID 32 A system for the identification of Clostridium species.

    PubMed

    Kim, Young Jin; Kim, Si Hyun; Park, Hyun-Jung; Park, Hae-Geun; Park, Dongchul; Song, Sae Am; Lee, Hee Joo; Yong, Dongeun; Choi, Jun Yong; Kook, Joong-Ki; Kim, Hye Ran; Shin, Jeong Hwan

    2016-08-01

    All 50 Clostridium difficile strains were definitely identified by Vitek2 system, Rapid ID 32A system, and MALDI-TOF. For 18 non-difficile Clostridium strains, the identification results were correct in 0, 2, and 17 strains by Vitek2, Rapid ID 32A, and MALDI-TOF, respectively. MALDI-TOF could be used as the primary tool for identification of Clostridium species.

  8. MALDI-TOF MS is more accurate than VITEK II ANC card and API Rapid ID 32 A system for the identification of Clostridium species.

    PubMed

    Kim, Young Jin; Kim, Si Hyun; Park, Hyun-Jung; Park, Hae-Geun; Park, Dongchul; Song, Sae Am; Lee, Hee Joo; Yong, Dongeun; Choi, Jun Yong; Kook, Joong-Ki; Kim, Hye Ran; Shin, Jeong Hwan

    2016-08-01

    All 50 Clostridium difficile strains were definitely identified by Vitek2 system, Rapid ID 32A system, and MALDI-TOF. For 18 non-difficile Clostridium strains, the identification results were correct in 0, 2, and 17 strains by Vitek2, Rapid ID 32A, and MALDI-TOF, respectively. MALDI-TOF could be used as the primary tool for identification of Clostridium species. PMID:27296834

  9. Human periosteal-derived cell expansion in a perfusion bioreactor system: proliferation, differentiation and extracellular matrix formation.

    PubMed

    Sonnaert, M; Papantoniou, I; Bloemen, V; Kerckhofs, G; Luyten, F P; Schrooten, J

    2014-09-01

    Perfusion bioreactor systems have shown to be a valuable tool for the in vitro development of three-dimensional (3D) cell-carrier constructs. Their use for cell expansion, however, has been much less explored. Since maintenance of the initial cell phenotype is essential in this process, it is imperative to obtain insight into the bioreactor-related variables determining cell fate. Therefore, this study investigated the influence of fluid flow-induced shear stress on the proliferation, differentiation and matrix deposition of human periosteal-derived cells in the absence of additional differentiation-inducing stimuli; 120 000 cells were seeded on additive manufactured 3D Ti6Al4V scaffolds and cultured for up to 28 days at different flow rates in the range 0.04-6 ml/min. DNA measurements showed, on average, a three-fold increase in cell content for all perfused conditions in comparison to static controls, whereas the magnitude of the flow rate did not have an influence. Contrast-enhanced nanofocus X-ray computed tomography showed substantial formation of an engineered neotissue in all perfused conditions, resulting in a filling (up to 70%) of the total internal void volume, and no flow rate-dependent differences were observed. The expression of key osteogenic markers, such as RunX2, OCN, OPN and Col1, did not show any significant changes in comparison to static controls after 28 days of culture, with the exception of OSX at high flow rates. We therefore concluded that, in the absence of additional osteogenic stimuli, the investigated perfusion conditions increased cell proliferation but did not significantly enhance osteogenic differentiation, thus allowing for this process to be used for cell expansion. Copyright © 2014 John Wiley & Sons, Ltd. PMID:25186024

  10. NNLOPS accurate associated HW production

    NASA Astrophysics Data System (ADS)

    Astill, William; Bizon, Wojciech; Re, Emanuele; Zanderighi, Giulia

    2016-06-01

    We present a next-to-next-to-leading order accurate description of associated HW production consistently matched to a parton shower. The method is based on reweighting events obtained with the HW plus one jet NLO accurate calculation implemented in POWHEG, extended with the MiNLO procedure, to reproduce NNLO accurate Born distributions. Since the Born kinematics is more complex than the cases treated before, we use a parametrization of the Collins-Soper angles to reduce the number of variables required for the reweighting. We present phenomenological results at 13 TeV, with cuts suggested by the Higgs Cross section Working Group.

  11. The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression.

    PubMed

    Saurí, J; Millán, D; Suñé-Negre, J M; Pérez-Lozano, P; Sarrate, R; Fàbregas, A; Carrillo, C; Miñarro, M; Ticó, J R; García-Montoya, E

    2014-01-30

    The SeDeM diagram expert system has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril direct compression SR matrix tablets. The application of the SeDeM diagram expert system enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM diagram expert system as system responses.

  12. Evaluation of lexicon size variations on a verification and rejection system based on SVM, for accurate and robust recognition of handwritten words

    NASA Astrophysics Data System (ADS)

    Ricquebourg, Yann; Coüasnon, Bertrand; Guichard, Laurent

    2013-01-01

    The transcription of handwritten words remains a still challenging and difficult task. When processing full pages, approaches are limited by the trade-off between automatic recognition errors and the tedious aspect of human user verification. In this article, we present our investigations to improve the capabilities of an automatic recognizer, so as to be able to reject unknown words (not to take wrong decisions) while correctly rejecting (i.e. to recognize as much as possible from the lexicon of known words). This is the active research topic of developing a verification system that optimize the trade-off between performance and reliability. To minimize the recognition errors, a verification system is usually used to accept or reject the hypotheses produced by an existing recognition system. Thus, we re-use our novel verification architecture1 here: the recognition hypotheses are re-scored by a set of support vector machines, and validated by a verification mechanism based on multiple rejection thresholds. In order to tune these (class-dependent) rejection thresholds, an algorithm based on dynamic programming has been proposed which focus on maximizing the recognition rate for a given error rate. Experiments have been carried out on the RIMES database in three steps. The first two showed that this approach results in a performance superior or equal to other state-of-the-art rejection methods. We focus here on the third one showing that this verification system also greatly improves results of keywords extraction in a set of handwritten words, with a strong robustness to lexicon size variations (21 lexicons have been tested from 167 entries up to 5,600 entries) which is particularly relevant to our application context cooperating with humans, and only made possible thanks to the rejection ability of this proposed system. The proposed verification system, compared to a HMM with simple rejection, improves on average the recognition rate by 57% (resp. 33% and 21%) for

  13. Inference from matrix products: a heuristic spin glass algorithm

    SciTech Connect

    Hastings, Matthew B

    2008-01-01

    We present an algorithm for finding ground states of two-dimensional spin-glass systems based on ideas from matrix product states in quantum information theory. The algorithm works directly at zero temperature and defines an approximation to the energy whose accuracy depends on a parameter k. We test the algorithm against exact methods on random field and random bond Ising models, and we find that accurate results require a k which scales roughly polynomially with the system size. The algorithm also performs well when tested on small systems with arbitrary interactions, where no fast, exact algorithms exist. The time required is significantly less than Monte Carlo schemes.

  14. Student Information Systems Demystified: The Increasing Demand for Accurate, Timely Data Means Schools and Districts Are Relying Heavily on SIS Technologies

    ERIC Educational Resources Information Center

    McIntire, Todd

    2004-01-01

    Student information systems, one of the first applications of computer technology in education, are undergoing a significant transition yet again. The first major shift in SIS technologies occurred about 15 years ago when they evolved from mainframe programs to client-server solutions. Now, vendors across the board are offering centralized…

  15. Role of solvent on protein-matrix coupling in MbCO embedded in water-saccharide systems: a Fourier transform infrared spectroscopy study.

    PubMed

    Giuffrida, Sergio; Cottone, Grazia; Cordone, Lorenzo

    2006-08-01

    Embedding protein in sugar systems of low water content enables one to investigate the protein dynamic-structure function in matrixes whose rigidity is modulated by varying the content of residual water. Accordingly, studying the dynamics and structure thermal evolution of a protein in sugar systems of different hydration constitutes a tool for disentangling solvent rigidity from temperature effects. Furthermore, studies performed using different sugars may give information on how the detailed composition of the surrounding solvent affects the internal protein dynamics and structural evolution. In this work, we compare Fourier transform infrared spectroscopy measurements (300-20 K) on MbCO embedded in trehalose, sucrose, maltose, raffinose, and glucose matrixes of different water content. At all the water contents investigated, the protein-solvent coupling was tighter in trehalose than in the other sugars, thus suggesting a molecular basis for the trehalose peculiarity. These results are in line with the observation that protein-matrix phase separation takes place in lysozyme-lactose, whereas it is absent in lysozyme-trehalose systems; indeed, these behaviors may respectively be due to the lack or presence of suitable water-mediated hydrogen-bond networks, which match the protein surface to the surroundings. The above processes might be at the basis of pattern recognition in crowded living systems; indeed, hydration shells structural and dynamic matching is first needed for successful come together of interacting biomolecules.

  16. Role of Solvent on Protein-Matrix Coupling in MbCO Embedded in Water-Saccharide Systems: A Fourier Transform Infrared Spectroscopy Study

    PubMed Central

    Giuffrida, Sergio; Cottone, Grazia; Cordone, Lorenzo

    2006-01-01

    Embedding protein in sugar systems of low water content enables one to investigate the protein dynamic-structure function in matrixes whose rigidity is modulated by varying the content of residual water. Accordingly, studying the dynamics and structure thermal evolution of a protein in sugar systems of different hydration constitutes a tool for disentangling solvent rigidity from temperature effects. Furthermore, studies performed using different sugars may give information on how the detailed composition of the surrounding solvent affects the internal protein dynamics and structural evolution. In this work, we compare Fourier transform infrared spectroscopy measurements (300–20 K) on MbCO embedded in trehalose, sucrose, maltose, raffinose, and glucose matrixes of different water content. At all the water contents investigated, the protein-solvent coupling was tighter in trehalose than in the other sugars, thus suggesting a molecular basis for the trehalose peculiarity. These results are in line with the observation that protein-matrix phase separation takes place in lysozyme-lactose, whereas it is absent in lysozyme-trehalose systems; indeed, these behaviors may respectively be due to the lack or presence of suitable water-mediated hydrogen-bond networks, which match the protein surface to the surroundings. The above processes might be at the basis of pattern recognition in crowded living systems; indeed, hydration shells structural and dynamic matching is first needed for successful come together of interacting biomolecules. PMID:16714349

  17. Accurate identification of the frequency response functions for the rotor-bearing-foundation system using the modified pseudo mode shape method

    NASA Astrophysics Data System (ADS)

    Chen, Yeong-Shu; Cheng, Ye-Dar; Yang, Tachung; Koai, Kwang-Lu

    2010-03-01

    In this paper, an identification technique in the dynamic analyses of rotor-bearing-foundation systems called the pseudo mode shape method (PMSM) was improved in order to enhance the accuracy of the identified dynamic characteristic matrices of its foundation models. Two procedures, namely, phase modification and numerical optimisation, were proposed in the algorithm of PMSM to effectively improve its accuracy. Generally, it is always necessary to build the whole foundation model in studying the dynamics of a rotor system through the finite element analysis method. This is either unfeasible or impractical when the foundation is too complicated. Instead, the PMSM uses the frequency response function (FRF) data of joint positions between the rotor and the foundation to establish the equivalent mass, damping, and stiffness matrices of the foundation without having to build the physical model. However, the accuracy of the obtained system's FRF is still unsatisfactory, especially at those higher modes. In order to demonstrate the effectiveness of the presented methods, a solid foundation was solved for its FRF by using both the original and modified PMSM, as well as the finite element (ANSYS) model for comparisons. The results showed that the accuracy of the obtained FRF was improved remarkably with the modified PMSM based on the results of the ANSYS. In addition, an induction motor resembling a rotor-bearing-foundation system, with its housing treated as the foundation, was taken as an example to verify the algorithm experimentally. The FRF curves at the bearing supports of the rotor (armature) were obtained through modal testing to estimate the above-mentioned equivalent matrices of the housing. The FRF of the housing, which was calculated from the equivalent matrices with the modified PMSM, showed satisfactory consistency with that from the modal testing.

  18. Application of matrix singular value properties for evaluating gain and phase margins of multiloop systems. [stability margins for wing flutter suppression and drone lateral attitude control

    NASA Technical Reports Server (NTRS)

    Mukhopadhyay, V.; Newsom, J. R.

    1982-01-01

    A stability margin evaluation method in terms of simultaneous gain and phase changes in all loops of a multiloop system is presented. A universal gain-phase margin evaluation diagram is constructed by generalizing an existing method using matrix singular value properties. Using this diagram and computing the minimum singular value of the system return difference matrix over the operating frequency range, regions of guaranteed stability margins can be obtained. Singular values are computed for a wing flutter suppression and a drone lateral attitude control problem. The numerical results indicate that this method predicts quite conservative stability margins. In the second example if the eigenvalue magnitude is used instead of the singular value, as a measure of nearness to singularity, more realistic stability margins are obtained. However, this relaxed measure generally cannot guarantee global stability.

  19. M-matrix based robust stability and stabilization for uncertain discrete-time switched TS fuzzy systems with time-varying delays.

    PubMed

    Jaballi, Ahmed; Sakly, Anis; Hajjaji, Ahmed El

    2016-07-01

    This paper provides novel sufficient conditions on robust asymptotic stability and stabilization for a class of uncertain discrete-time switched fuzzy with time-varying delays. The attention is focused on developing new algebraic criteria to break with classical criteria in terms of Linear Matrix Inequalities (LMIs). Firstly, based on the M-matrix proprieties and through l1,∞ induced norms notion, new delay-dependent sufficient conditions are derived to ensure the asymptotic stability and stabilization for a class of uncertain discrete-time switched fuzzy systems with time-varying delay. Secondly, these results are extended for a class of uncertain discrete-time switched fuzzy systems with time delays, modeled by difference equations. Finally, two numerical examples and practical example (a robot arm) are provided to demonstrate the advantage and the effectiveness of our results. PMID:26996925

  20. Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury

    PubMed Central

    Phillips, Linda L.; Chan, Julie L.; Doperalski, Adele E.; Reeves, Thomas M.

    2014-01-01

    Over the past two decades, many investigators have reported how extracellular matrix molecules act to regulate neuroplasticity. The majority of these studies involve proteins which are targets of matrix metalloproteinases. Importantly, these enzyme/substrate interactions can regulate degenerative and regenerative phases of synaptic plasticity, directing axonal and dendritic reorganization after brain insult. The present review first summarizes literature support for the prominent role of matrix metalloproteinases during neuroregeneration, followed by a discussion of data contrasting adaptive and maladaptive neuroplasticity that reveals time-dependent metalloproteinase/substrate regulation of postinjury synaptic recovery. The potential for these enzymes to serve as therapeutic targets for enhanced neuroplasticity after brain injury is illustrated with experiments demonstrating that metalloproteinase inhibitors can alter adaptive and maladaptive outcome. Finally, the complexity of metalloproteinase role in reactive synaptogenesis is revealed in new studies showing how these enzymes interact with immune molecules to mediate cellular response in the local regenerative environment, and are regulated by novel binding partners in the brain extracellular matrix. Together, these different examples show the complexity with which metalloproteinases are integrated into the process of neuroregeneration, and point to a promising new angle for future studies exploring how to facilitate brain plasticity. PMID:25206824