Sample records for acetate bia 2-093

  1. 25 CFR 166.2 - Can the BIA waive the application of these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can the BIA waive the application of these regulations? 166.2 Section 166.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Purpose, Scope, and Definitions § 166.2 Can the BIA waive the application of these...

  2. 25 CFR 166.2 - Can the BIA waive the application of these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can the BIA waive the application of these regulations? 166.2 Section 166.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Purpose, Scope, and Definitions § 166.2 Can the BIA waive the application of these...

  3. Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine.

    PubMed

    Hainzl, D; Parada, A; Soares-da-Silva, P

    2001-05-01

    BIA 2-093 and BIA 2-059 are two stereoisomers under development as new antiepileptic drugs. They act as prodrugs for the corresponding hydroxy derivatives (S(+)- or R(-)-10,11-dihydro-10-hydroxy carbamazepine, respectively) which are known to be the active metabolites of the antiepileptic drug oxcarbazepine (OXC). The purpose of this study was to define the metabolic pathway especially in terms of stereoselectivity, and to estimate the possibility of racemization in humans. For in vivo studies, the rat, mouse and rabbit were chosen as models in order to cover a broad spectrum of metabolic activity. In addition, incubations with liver microsomes from these three species plus dog and monkey were compared to results obtained with human liver microsomes. It was found that both drugs were almost instantly hydrolysed to the corresponding 10-hydroxy compounds in mice, rats and rabbits. Mice and rabbits were not able to oxidize the 10-hydroxy compounds to OXC in significant amounts. In the rat, BIA 2-093 also gave origin to OXC, whereas BIA 2-059 resulted in the formation of OXC and the trans-diol metabolite in equal amounts. It could be shown that the rat is able to reduce the formed OXC in liver to S(+)-10-hydroxy metabolite, resulting in a loss of enantiomeric purity after treatment with BIA 2-059 rather than in the case of BIA 2-093. Human liver microsomes hydrolysed BIA 2-093 and BIA 2-059 to their corresponding 10-hydroxy compounds and to OXC in a very small extent with BIA 2-093 only. Therefore, BIA 2-093 and BIA 2-059 seem to be preferable drugs over OXC since they most likely exhibit a 'cleaner' metabolism. From a therapeutic point of view BIA 2-059 would be less appropriate than BIA 2-093 for the purpose of treating epileptic patients due to its propensity to undergo inactivation to the trans-diol.

  4. 40 CFR 86.093-2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 1977 and Later Model Year New Light-Duty Vehicles, Light-Duty Trucks and Heavy-Duty Engines, and for 1985 and Later Model Year New Gasoline Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and...-11 and 86.093-35. Centrally fueled bus means a bus that is refueled at least 75 percent of the time...

  5. 40 CFR 86.093-2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 1977 and Later Model Year New Light-Duty Vehicles, Light-Duty Trucks and Heavy-Duty Engines, and for 1985 and Later Model Year New Gasoline Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and...-11 and 86.093-35. Centrally fueled bus means a bus that is refueled at least 75 percent of the time...

  6. Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.

    PubMed

    Gama, Helena; Vieira, Mariana; Costa, Raquel; Graça, Joana; Magalhães, Luís M; Soares-da-Silva, Patrício

    2017-12-01

    Eslicarbazepine acetate was first approved in the European Union in 2009 as adjunctive therapy in adults with partial-onset seizures with or without secondary generalization. The objective of this study was to review the safety profile of eslicarbazepine acetate analyzing the data from several clinical studies to 6 years of post-marketing surveillance. We used a post-hoc pooled safety analysis of four phase III, double-blind, randomized, placebo-controlled studies (BIA-2093-301, -302, -303, -304) of eslicarbazepine acetate as add-on therapy in adults. Safety data of eslicarbazepine acetate in special populations of patients aged ≥65 years with partial-onset seizures (BIA-2093-401) and subjects with moderate hepatic impairment (BIA-2093-111) and renal impairment (BIA-2093-112) are also considered. The incidences of treatment-emergent adverse events, treatment-emergent adverse events leading to discontinuation, and serious adverse events were analyzed. The global safety database of eslicarbazepine acetate was analyzed for all cases from post-marketing surveillance from 1 October, 2009 to 21 October, 2015. From a pooled analysis of four phase III studies, it was concluded that the incidence of treatment-emergent adverse events, treatment-emergent adverse events leading to discontinuation, and adverse drug reactions were dose dependent. Dizziness, somnolence, headache, and nausea were the most common treatment-emergent adverse events (≥10% of patients) and the majority were of mild-to-moderate intensity. No dose-dependent trend was observed for serious adverse events and individual serious adverse events were reported in less than 1% of patients. Hyponatremia was classified as a possibly related treatment-emergent adverse event in phase III studies (1.2%); however, after 6 years of post-marketing surveillance it represents the most frequently (10.2%) reported adverse drug reaction, with more than half of these cases occurring with eslicarbazepine acetate at

  7. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What is the IRR Program and BIA Road Maintenance Program... INDIAN RESERVATION ROADS PROGRAM Policies, Applicability, and Definitions § 170.2 What is the IRR Program and BIA Road Maintenance Program policy? (a) It is the policy of the Secretary of the Interior and the...

  8. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What is the IRR Program and BIA Road Maintenance Program... INDIAN RESERVATION ROADS PROGRAM Policies, Applicability, and Definitions § 170.2 What is the IRR Program and BIA Road Maintenance Program policy? (a) It is the policy of the Secretary of the Interior and the...

  9. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What is the IRR Program and BIA Road Maintenance Program... INDIAN RESERVATION ROADS PROGRAM Policies, Applicability, and Definitions § 170.2 What is the IRR Program and BIA Road Maintenance Program policy? (a) It is the policy of the Secretary of the Interior and the...

  10. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the IRR Program and BIA Road Maintenance Program... and BIA Road Maintenance Program policy? (a) It is the policy of the Secretary of the Interior and the... designed to enable Indian tribes to participate in all contractible IRR and BIA Road Maintenance programs...

  11. What makes a BIA equation unique? Validity of 8-electrode multifrequency-BIA to estimate body compostion in a healthy adult population

    USDA-ARS?s Scientific Manuscript database

    The validity of bioelectrical impedance analysis (BIA) for body composition analysis is limited by assumptions relating to body shape. Improvement in BIA technology could overcome these limitations and reduce the population specificity of the BIA algorithm. BIA equations for the prediction of fat ...

  12. Preliminary bioelectrical impedance analysis (BIA) equation for body composition assessment in young females from Colombia

    NASA Astrophysics Data System (ADS)

    Caicedo-Eraso, J. C.; González-Correa, C. H.; González-Correa, C. A.

    2013-04-01

    A previous study showed that reported BIA equations for body composition are not suitable for Colombian population. The purpose of this study was to develop and validate a preliminary BIA equation for body composition assessment in young females from Colombia, using hydrodensitometry as reference method. A sample of 30 young females was evaluated. Inclusion and exclusion criteria were defined to minimize the variability of BIA. Height, weight, BIA, residual lung volume (RV) and underwater weight (UWW) were measured. A preliminary BIA equation was developed (r2 = 0.72, SEE = 2.48 kg) by stepwise multiple regression with fat-free mass (FFM) as dependent variable and weight, height and impedance measurements as independent variables. The quality of regression was evaluated and a cross-validation against 50% of sample confirmed that results obtained with the preliminary BIA equation is interchangeable with results obtained with hydrodensitometry (r2 = 0.84, SEE = 2.62 kg). The preliminary BIA equation can be used for body composition assessment in young females from Colombia until a definitive equation is developed. The next step will be increasing the sample, including a second reference method, as deuterium oxide dilution (D2O), and using multi-frequency BIA (MF-BIA). It would also be desirable to develop equations for males and other ethnic groups in Colombia.

  13. 25 CFR 170.801 - What is the BIA Road Maintenance Program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the BIA Road Maintenance Program? 170.801 Section... ROADS PROGRAM BIA Road Maintenance § 170.801 What is the BIA Road Maintenance Program? The BIA Road... subpart contains a list of activities that are eligible for funding under the BIA road maintenance program. ...

  14. 25 CFR 161.701 - What is BIA's trespass policy?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is BIA's trespass policy? 161.701 Section 161.701... GRAZING PERMITS Trespass § 161.701 What is BIA's trespass policy? BIA will: (a) Investigate accidental, willful, and/or incidental trespass on Navajo Partitioned Lands; (b) Respond to alleged trespass in a...

  15. 25 CFR 161.701 - What is BIA's trespass policy?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is BIA's trespass policy? 161.701 Section 161.701... GRAZING PERMITS Trespass § 161.701 What is BIA's trespass policy? BIA will: (a) Investigate accidental, willful, and/or incidental trespass on Navajo Partitioned Lands; (b) Respond to alleged trespass in a...

  16. 25 CFR 161.701 - What is BIA's trespass policy?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What is BIA's trespass policy? 161.701 Section 161.701... GRAZING PERMITS Trespass § 161.701 What is BIA's trespass policy? BIA will: (a) Investigate accidental, willful, and/or incidental trespass on Navajo Partitioned Lands; (b) Respond to alleged trespass in a...

  17. 25 CFR 161.701 - What is BIA's trespass policy?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What is BIA's trespass policy? 161.701 Section 161.701... GRAZING PERMITS Trespass § 161.701 What is BIA's trespass policy? BIA will: (a) Investigate accidental, willful, and/or incidental trespass on Navajo Partitioned Lands; (b) Respond to alleged trespass in a...

  18. 25 CFR 161.701 - What is BIA's trespass policy?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What is BIA's trespass policy? 161.701 Section 161.701... GRAZING PERMITS Trespass § 161.701 What is BIA's trespass policy? BIA will: (a) Investigate accidental, willful, and/or incidental trespass on Navajo Partitioned Lands; (b) Respond to alleged trespass in a...

  19. 25 CFR 170.2 - What is the IRR Program and BIA Road Maintenance Program policy?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the IRR Program and BIA Road Maintenance Program policy? 170.2 Section 170.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Policies, Applicability, and Definitions § 170.2 What is the IRR Program...

  20. 25 CFR 161.601 - How will BIA monitor permit compliance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will BIA monitor permit compliance? 161.601 Section 161.601 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Permit Violations § 161.601 How will BIA monitor permit compliance? Unless the permit provides otherwise, BIA and/or Navajo...

  1. 25 CFR 161.601 - How will BIA monitor permit compliance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will BIA monitor permit compliance? 161.601 Section 161.601 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Permit Violations § 161.601 How will BIA monitor permit compliance? Unless the permit provides otherwise, BIA and/or Navajo...

  2. [Abdomen specific bioelectrical impedance analysis (BIA) methods for evaluation of abdominal fat distribution].

    PubMed

    Ida, Midori; Hirata, Masakazu; Hosoda, Kiminori; Nakao, Kazuwa

    2013-02-01

    Two novel bioelectrical impedance analysis (BIA) methods have been developed recently for evaluation of intra-abdominal fat accumulation. Both methods use electrodes that are placed on abdominal wall and allow evaluation of intra-abdominal fat area (IAFA) easily without radiation exposure. Of these, "abdominal BIA" method measures impedance distribution along abdominal anterior-posterior axis, and IAFA by BIA method(BIA-IAFA) is calculated from waist circumference and the voltage occurring at the flank. Dual BIA method measures impedance of trunk and body surface at the abdominal level and calculates BIA-IAFA from transverse and antero-posterior diameters of the abdomen and the impedance of trunk and abdominal surface. BIA-IAFA by these two BIA methods correlated well with IAFA measured by abdominal CT (CT-IAFA) with correlatipn coefficient of 0.88 (n = 91, p < 0.0001) for the former, and 0.861 (n = 469, p < 0.01) for the latter. These new BIA methods are useful for evaluating abdominal adiposity in clinical study and routine clinical practice of metabolic syndrome and obesity.

  3. 34 CFR 673.6 - Coordination with BIA grants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EDUCATION, DEPARTMENT OF EDUCATION GENERAL PROVISIONS FOR THE FEDERAL PERKINS LOAN PROGRAM, FEDERAL WORK... Federal Perkins Loan, FWS, and FSEOG Programs § 673.6 Coordination with BIA grants. (a) Coordination of BIA grants with Federal Perkins loans, FWS awards, or FSEOGs. To determine the amount of a Federal...

  4. 34 CFR 673.6 - Coordination with BIA grants.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EDUCATION, DEPARTMENT OF EDUCATION GENERAL PROVISIONS FOR THE FEDERAL PERKINS LOAN PROGRAM, FEDERAL WORK... Federal Perkins Loan, FWS, and FSEOG Programs § 673.6 Coordination with BIA grants. (a) Coordination of BIA grants with Federal Perkins loans, FWS awards, or FSEOGs. To determine the amount of a Federal...

  5. 28 CFR 0.93 - Bureau of Justice Statistics.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Bureau of Justice Statistics. 0.93...-Office of Justice Programs and Related Agencies § 0.93 Bureau of Justice Statistics. The Bureau of Justice Statistics is headed by a Director appointed by the President. Under the general authority of the...

  6. 28 CFR 0.93 - Bureau of Justice Statistics.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Bureau of Justice Statistics. 0.93...-Office of Justice Programs and Related Agencies § 0.93 Bureau of Justice Statistics. The Bureau of Justice Statistics is headed by a Director appointed by the President. Under the general authority of the...

  7. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible for maintenance under the BIA Road Maintenance Program: (1) BIA transportation facilities listed in...

  8. 22 Cases of BIA-ALCL: Awareness and Outcome Tracking from the Italian Ministry of Health.

    PubMed

    Antonella, Campanale; Rosaria, Boldrini; Marcella, Marletta

    2017-09-13

    To date, 359 cases of anaplastic large cell lymphoma in women with breast implants (BIA-ALCL) worldwide have been reported out of more than 10 million implanted patients but Health Care Authorities suspect this is a possible underestimation and the limited number of cases makes it difficult to clarify its etiology. The General Directorate of Medical Devices and Pharmaceutical Services of the Italian Ministry of Health (IMoH) has examined and studied the Italian BIA-ALCL cases, and the aim of this study is to report on the knowledge and experience gained on this new emerging disease. An official document has been diffused by the IMoH to all the Italian medical associations, aiming at encouraging all physicians to notify each BIA-ALCL case through the compilation of a specific on-line form. A retrospective study has been performed on the notified BIA-ALCL cases collected in the IMoH's database named DISPOVIGILANCE. Research on DISPOVIGILANCE gives back a list of 22 Italian BIA-ALCL cases. The patients' mean age was 49.6 years (range 30 -71). The average time to the onset of the symptoms was 6.8 years (range 1-22). The average time to the diagnosis was 7.8 years (range 4 -22). The estimated incidence of the Italian BIA-ALCL cases related to 2015 is 2.8 per 100.000 patients. The BIA-ALCL pathogenesis remains unknown. The Italian Ministry of Health, together with scientific associations and other Competent Authorities worldwide, is working on the BIA-ALCL issue to increase awareness and knowledge of this disease by healthcare professionals.

  9. 25 CFR 170.472 - What construction records must tribes and BIA keep?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What construction records must tribes and BIA keep? 170... Construction and Construction Monitoring § 170.472 What construction records must tribes and BIA keep? The following table shows which IRR construction records BIA and tribes must keep and the requirements for...

  10. 43 CFR 30.264 - When must BIA furnish a valuation of a decedent's interests?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false When must BIA furnish a valuation of a... BIA furnish a valuation of a decedent's interests? (a) BIA must furnish a valuation report of the..., BIA must furnish a valuation report in the probate file when it is submitted to OHA. Interested...

  11. 25 CFR 171.125 - Can I appeal BIA decisions?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I appeal BIA decisions? 171.125 Section 171.125 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE General Provisions § 171.125 Can I appeal BIA decisions? (a) You may appeal our decisions in...

  12. 25 CFR 103.14 - Can BIA request additional information?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA request additional information? 103.14 Section 103.14 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY How a Lender Obtains a Loan Guaranty or Insurance Coverage § 103.14 Can BIA...

  13. sts093-s-016

    NASA Image and Video Library

    1999-07-27

    STS093-(S)-016 (27 July 1999) --- Members of the STS-93 crew pose in front of the Space Shuttle Columbia following the night landing on runway 33 at Kennedy Space Center's Shuttle Landing Facility. From the left are astronauts Catherine G. (Cady) Coleman and Steven A. Hawley, both mission specialists; Jeffrey S. Ashby, pilot; Eileen M. Collins, mission commander; and Michel Tognini, mission specialist representing France's Centre National d'Etudes Spatiales (CNES). Main gear touchdown occurred at 11:20:35 p.m.(EDT), July 27, 1999.

  14. 25 CFR 170.804 - How is BIA's Road Maintenance Program related to the IRR Program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How is BIA's Road Maintenance Program related to the IRR... WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.804 How is BIA's Road Maintenance Program related to the IRR Program? The following chart illustrates how BIA's Road Maintenance Program is...

  15. 25 CFR 161.706 - What actions does BIA take against trespassers?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.706 What actions does BIA take against trespassers... property involved in the trespass. BIA may keep the property seized for use as evidence. (b) Assess...

  16. 25 CFR 161.706 - What actions does BIA take against trespassers?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.706 What actions does BIA take against trespassers... property involved in the trespass. BIA may keep the property seized for use as evidence. (b) Assess...

  17. 25 CFR 161.706 - What actions does BIA take against trespassers?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.706 What actions does BIA take against trespassers... property involved in the trespass. BIA may keep the property seized for use as evidence. (b) Assess...

  18. 25 CFR 161.706 - What actions does BIA take against trespassers?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.706 What actions does BIA take against trespassers... property involved in the trespass. BIA may keep the property seized for use as evidence. (b) Assess...

  19. 25 CFR 161.706 - What actions does BIA take against trespassers?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.706 What actions does BIA take against trespassers... property involved in the trespass. BIA may keep the property seized for use as evidence. (b) Assess...

  20. sts093-s-013

    NASA Image and Video Library

    1999-06-27

    STS093-S-013 (27 June 1999) --- In this fish-eye view, the Chandra X-ray Observatory rests inside the payload bay of the Space Shuttle Columbia at the Kennedy Space Center (KSC). Chandra is the primary payload on the STS-93 mission, scheduled to launch next month. The world's most powerful X-ray telescope, Chandra, will allow scientists from around the world to see previously invisible black holes and high-temperature gas clouds, giving the observatory the potential to rewrite the books on the structure and evolution of the universe.

  1. 23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR part...

  2. 23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR part...

  3. Utilization of BIA-Derived Bone Mineral Estimates Exerts Minimal Impact on Body Fat Estimates via Multicompartment Models in Physically Active Adults.

    PubMed

    Nickerson, Brett S; Tinsley, Grant M

    2018-03-21

    The purpose of this study was to compare body fat estimates and fat-free mass (FFM) characteristics produced by multicompartment models when utilizing either dual energy X-ray absorptiometry (DXA) or single-frequency bioelectrical impedance analysis (SF-BIA) for bone mineral content (BMC) in a sample of physically active adults. Body fat percentage (BF%) was estimated with 5-compartment (5C), 4-compartment (4C), 3-compartment (3C), and 2-compartment (2C) models, and DXA. The 5C-Wang with DXA for BMC (i.e., 5C-Wang DXA ) was the criterion. 5C-Wang using SF-BIA for BMC (i.e., 5C-Wang BIA ), 4C-Wang DXA (DXA for BMC), 4C-Wang BIA (BIA for BMC), and 3C-Siri all produced values similar to 5C-Wang DXA (r > 0.99; total error [TE] < 0.83%; standard error of estimate < 0.67%; 95% limits of agreement [LOAs] < ±1.35%). The 2C models (2C-Pace, 2C-Siri, and 2C-Brozek) and DXA each produced similar standard error of estimate and 95% LOAs (2.13%-3.12% and ±4.15%-6.14%, respectively). Furthermore, 3C-Lohman DXA (underwater weighing for body volume and DXA for BMC) and 3C-Lohman BIA (underwater weighing for body volume and SF-BIA for BMC) produced the largest 95% LOAs (±5.94%-8.63%). The FFM characteristics (i.e., FFM density, water/FFM, mineral/FFM, and protein/FFM) for 5C-Wang DXA and 5C-Wang BIA were each compared with the "reference body" cadavers of Brozek et al. 5C-Wang BIA FFM density differed significantly from the "reference body" in women (1.103 ± 0.007 g/cm 3 ; p < 0.001), but no differences were observed for 5C-Wang DXA or either 5C model in men. Moreover, water/FFM and mineral/FFM were significantly lower in men and women when comparing 5C-Wang DXA and 5C-Wang BIA with the "reference body," whereas protein/FFM was significantly higher (all p ≤ 0.001). 3C-Lohman BIA and 3C-Lohman DXA produced error similar to 2C models and DXA and are therefore not recommended multicompartment models. Although more advanced multicompartment models (e

  4. 25 CFR 161.800 - How does the Navajo Nation provide concurrence to BIA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Navajo Nation provide concurrence to BIA... Nation provide concurrence to BIA? (a) Actions taken by BIA under this part require concurrence of the Navajo Nation under section 640d-9(e)(1)(A) of the Settlement Act. (b) For any action requiring the...

  5. The BIA/Contract School Secondary Administrator: Characteristics and Leadership Style.

    ERIC Educational Resources Information Center

    Chance, Edward W.

    This study of the Bureau of Indian Affairs (BIA) and contract secondary school administrators creates a BIA administrator profile and examines differences between Indian and non-Indian administrators. Two different instruments were mailed to 54 administrators. The first, with a return rate of 44%, was a questionnaire relating to administrative…

  6. Oxidation of indole-3-acetic acid and oxindole-3-acetic acid to 2,3-dihydro-7-hydroxy-2-oxo-1H indole-3-acetic acid-7'-O-beta-D-glucopyranoside in Zea mays seedlings

    NASA Technical Reports Server (NTRS)

    Nonhebel, H. M.; Bandurski, R. S.

    1984-01-01

    Radiolabeled oxindole-3-acetic acid was metabolized by roots, shoots, and caryopses of dark grown Zea mays seedlings to 2,3-dihydro-7-hydroxy-2-oxo-1H indole-3-acetic acid-7'-O-beta-D-glycopyranoside with the simpler name of 7-hydroxyoxindole-3-acetic acid-glucoside. This compound was also formed from labeled indole-3-acetic acid supplied to intact seedlings and root segments. The glucoside of 7-hydroxyoxindole-3-acetic acid was also isolated as an endogenous compound in the caryopses and shoots of 4-day-old seedlings. It accumulates to a level of 4.8 nanomoles per plant in the kernel, more than 10 times the amount of oxindole-3-acetic acid. In the shoot it is present at levels comparable to that of oxindole-3-acetic acid and indole-3-acetic acid (62 picomoles per shoot). We conclude that 7-hydroxyoxindole-3-acetic acid-glucoside is a natural metabolite of indole-3-acetic acid in Z. mays seedlings. From the data presented in this paper and in previous work, we propose the following route as the principal catabolic pathway for indole-3-acetic acid in Zea seedlings: Indole-3-acetic acid --> Oxindole-3-acetic acid --> 7-Hydroxyoxindole-3-acetic acid --> 7-Hydroxyoxindole-3-acetic acid-glucoside.

  7. 25 CFR 166.801 - What is the BIA's trespass policy?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the BIA's trespass policy? 166.801 Section 166... Trespass § 166.801 What is the BIA's trespass policy? We will: (a) Investigate accidental, willful, and/or incidental trespass on Indian agricultural land; (b) Respond to alleged trespass in a prompt, efficient...

  8. 25 CFR 166.801 - What is the BIA's trespass policy?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What is the BIA's trespass policy? 166.801 Section 166... Trespass § 166.801 What is the BIA's trespass policy? We will: (a) Investigate accidental, willful, and/or incidental trespass on Indian agricultural land; (b) Respond to alleged trespass in a prompt, efficient...

  9. 25 CFR 166.801 - What is the BIA's trespass policy?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the BIA's trespass policy? 166.801 Section 166... Trespass § 166.801 What is the BIA's trespass policy? We will: (a) Investigate accidental, willful, and/or incidental trespass on Indian agricultural land; (b) Respond to alleged trespass in a prompt, efficient...

  10. 25 CFR 166.801 - What is the BIA's trespass policy?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What is the BIA's trespass policy? 166.801 Section 166... Trespass § 166.801 What is the BIA's trespass policy? We will: (a) Investigate accidental, willful, and/or incidental trespass on Indian agricultural land; (b) Respond to alleged trespass in a prompt, efficient...

  11. 25 CFR 170.227 - How does BIA develop and use the IRR Inventory?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA develop and use the IRR Inventory? 170.227... Planning (lrtp) § 170.227 How does BIA develop and use the IRR Inventory? The IRR Inventory as defined in § 170.442 identifies the transportation need by providing the data that BIA uses to generate the Cost to...

  12. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What facilities are eligible under the BIA Road... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible...

  13. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What facilities are eligible under the BIA Road... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible...

  14. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What facilities are eligible under the BIA Road... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible...

  15. 25 CFR 170.803 - What facilities are eligible under the BIA Road Maintenance Program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What facilities are eligible under the BIA Road... AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.803 What facilities are eligible under the BIA Road Maintenance Program? (a) The following public transportation facilities are eligible...

  16. 25 CFR 166.801 - What is the BIA's trespass policy?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What is the BIA's trespass policy? 166.801 Section 166.801 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass § 166.801 What is the BIA's trespass policy? We will: (a) Investigate accidental, willful, and/or incidental...

  17. 25 CFR 171.300 - Does BIA restrict my water use?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Does BIA restrict my water use? 171.300 Section 171.300 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.300 Does BIA restrict my water use? (a) You must not interfere with or alter our...

  18. 25 CFR 170.605 - When may BIA use force account methods in the IRR Program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When may BIA use force account methods in the IRR Program... § 170.605 When may BIA use force account methods in the IRR Program? BIA may use force account methods... account project activities. ...

  19. AIPRC--BIA Management Study: Personnel Management

    ERIC Educational Resources Information Center

    American Indian Journal, 1976

    1976-01-01

    Continuing the American Indian Policy Review Commission's (AIPRC) Bureau of Indian Affairs (BIA) Management Study, this article reviews the divisions of responsibility, Indian preference, recruitment and hiring problems, training, labor relations, and internal communication. (NQ)

  20. Synthesis of acetic acid via methanol hydrocarboxylation with CO2 and H2

    PubMed Central

    Qian, Qingli; Zhang, Jingjing; Cui, Meng; Han, Buxing

    2016-01-01

    Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a route to produce acetic acid from CO2, methanol and H2. The reaction can be efficiently catalysed by Ru–Rh bimetallic catalyst using imidazole as the ligand and LiI as the promoter in 1,3-dimethyl-2-imidazolidinone (DMI) solvent. It is confirmed that methanol is hydrocarboxylated into acetic acid by CO2 and H2, which accounts for the outstanding reaction results. The reaction mechanism is proposed based on the control experiments. The strategy opens a new way for acetic acid production and CO2 transformation, and represents a significant progress in synthetic chemistry. PMID:27165850

  1. Synthesis of acetic acid via methanol hydrocarboxylation with CO2 and H2.

    PubMed

    Qian, Qingli; Zhang, Jingjing; Cui, Meng; Han, Buxing

    2016-05-11

    Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a route to produce acetic acid from CO2, methanol and H2. The reaction can be efficiently catalysed by Ru-Rh bimetallic catalyst using imidazole as the ligand and LiI as the promoter in 1,3-dimethyl-2-imidazolidinone (DMI) solvent. It is confirmed that methanol is hydrocarboxylated into acetic acid by CO2 and H2, which accounts for the outstanding reaction results. The reaction mechanism is proposed based on the control experiments. The strategy opens a new way for acetic acid production and CO2 transformation, and represents a significant progress in synthetic chemistry.

  2. 25 CFR 170.808 - Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA Road Maintenance Program funds be used to improve... THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.808 Can BIA Road Maintenance Program funds be used to improve IRR transportation facilities? No. BIA Road...

  3. 25 CFR 1000.122 - What non-BIA programs are eligible for inclusion in an annual funding agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What non-BIA programs are eligible for inclusion in an... Funding Agreements Eligibility § 1000.122 What non-BIA programs are eligible for inclusion in an annual... inclusion in AFAs. The Secretary will publish annually a list of these programs in accordance with section...

  4. 25 CFR 1000.122 - What non-BIA programs are eligible for inclusion in an annual funding agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What non-BIA programs are eligible for inclusion in an... Funding Agreements Eligibility § 1000.122 What non-BIA programs are eligible for inclusion in an annual... inclusion in AFAs. The Secretary will publish annually a list of these programs in accordance with section...

  5. 25 CFR 1000.122 - What non-BIA programs are eligible for inclusion in an annual funding agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What non-BIA programs are eligible for inclusion in an... Funding Agreements Eligibility § 1000.122 What non-BIA programs are eligible for inclusion in an annual... inclusion in AFAs. The Secretary will publish annually a list of these programs in accordance with section...

  6. 25 CFR 1000.122 - What non-BIA programs are eligible for inclusion in an annual funding agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What non-BIA programs are eligible for inclusion in an... Funding Agreements Eligibility § 1000.122 What non-BIA programs are eligible for inclusion in an annual... inclusion in AFAs. The Secretary will publish annually a list of these programs in accordance with section...

  7. 25 CFR 1000.122 - What non-BIA programs are eligible for inclusion in an annual funding agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What non-BIA programs are eligible for inclusion in an... Funding Agreements Eligibility § 1000.122 What non-BIA programs are eligible for inclusion in an annual... inclusion in AFAs. The Secretary will publish annually a list of these programs in accordance with section...

  8. Validation of bioelectrical impedance analysis (BIA) for estimation of body composition in Black, White and Hispanic adolescent girls

    PubMed Central

    Going, S.; Nichols, J.; Loftin, M.; Stewart, D.; Lohman, T.; Tuuri, G.; Ring, K.; Pickrel, J.; Blew, R.; J.Stevens

    2007-01-01

    Aim Equations for estimating % fat mass (%BF) and fat-free mass (FFM) from bioelectrical impedance analysis (BIA) that work in adolescent girls from different racial/ethnic backgrounds are not available. We investigated whether race/ethnicity influences estimation of body composition in adolescent girls. Principal procedures Prediction equations were developed for estimating FFM and %BF from BIA in 166 girls, 10–15 years old, consisting of 51 Black (B), 45 non-Black Hispanic (H), 55 non-Hispanic White (W) and 15 mixed (M) race/ethnicity girls, using dual energy x-ray absorptiometry (DXA) as the criterion method. Findings Black girls had similar %BF compared to other groups, yet were heavier per unit of height according to body mass index (BMI: kg·m−2) due to significantly greater FFM. BIA resistance index, age, weight and race/ethnicity were all significant predictors of FFM (R2 = 0.92, SEE = 1.81 kg). Standardized regression coefficients showed resistance index (0.63) and weight (0.34) were the most important predictors of FFM. Errors in %BF (~2%) and FFM (~1.0 kg) were greater when race/ethnicity was not included in the equation, particularly in Black girls. We conclude the BIA-composition relationship in adolescent girls is influenced by race, and consequently have developed new BIA equations for adolescent girls for predicting FFM and %BF. PMID:17848976

  9. 25 CFR 171.300 - Does BIA restrict my water use?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Does BIA restrict my water use? 171.300 Section 171.300 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.300 Does BIA restrict my water use? (a) You must not interfere with or alter our service to you without our prior written...

  10. 25 CFR 171.300 - Does BIA restrict my water use?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Does BIA restrict my water use? 171.300 Section 171.300 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.300 Does BIA restrict my water use? (a) You must not interfere with or alter our service to you without our prior written...

  11. 25 CFR 171.300 - Does BIA restrict my water use?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Does BIA restrict my water use? 171.300 Section 171.300 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.300 Does BIA restrict my water use? (a) You must not interfere with or alter our service to you without our prior written...

  12. 25 CFR 166.306 - Can the BIA adjust the grazing capacity?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can the BIA adjust the grazing capacity? 166.306 Section 166.306 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Land and Operations Management § 166.306 Can the BIA adjust the grazing capacity? Yes. In consultation...

  13. STS093-S-002

    NASA Image and Video Library

    1998-09-01

    STS093-S-002 (September 1998) --- The five astronauts assigned to fly aboard the Space Shuttle Columbia early next year for the STS-93 mission pose with a small model of their primary payload-the Advanced X-ray Astrophysics Facility (AXAF). From the left are astronauts Eileen M. Collins, mission commander; Steven A. Hawley, mission specialist; Jeffrey S. Ashby, pilot; Michel Tognini and Catherine G. Coleman, both mission specialists. Tognini represents France's Centre National d'Etudes Spatiales (CNES). The scheduled five-day mission will feature the deployment of AXAF, which will enable scientists to conduct comprehensive studies of exotic phenomena in the universe. Among bodies studied will be exploding stars, quasars and black holes.

  14. 76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Adult Detention Facility Guidelines AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice. SUMMARY: This notice announces the online publication of the Interim BIA Adult Detention Facility Guidelines and... Indian Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines and Interim Model...

  15. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Will BIA provide leaching service to me? 171.305 Section 171.305 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide...

  16. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will BIA provide leaching service to me? 171.305 Section 171.305 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide...

  17. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Will BIA provide leaching service to me? 171.305 Section 171.305 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide...

  18. 25 CFR 1000.88 - Do Tribes/Consortia need Secretarial approval to redesign BIA programs that the Tribe/Consortium...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Do Tribes/Consortia need Secretarial approval to redesign BIA programs that the Tribe/Consortium administers under an AFA? 1000.88 Section 1000.88 Indians... in An Afa § 1000.88 Do Tribes/Consortia need Secretarial approval to redesign BIA programs that the...

  19. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Will BIA provide leaching service to me? 171.305 Section... OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide you leaching service if: (1) You submit a written plan that documents how soil salinity limits your...

  20. 25 CFR 171.305 - Will BIA provide leaching service to me?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will BIA provide leaching service to me? 171.305 Section... OPERATION AND MAINTENANCE Water Use § 171.305 Will BIA provide leaching service to me? (a) We may provide you leaching service if: (1) You submit a written plan that documents how soil salinity limits your...

  1. 25 CFR 170.231 - May a tribe challenge the data BIA uses in the RNDF?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... challenge the data BIA uses in the RNDF? (a) A tribe may submit a request to the BIA Regional Director to... submit a data correction request at any time. In order to impact the distribution in a given fiscal year... prior fiscal year. (c) The BIA Regional Director must respond within 30 days of receiving a data...

  2. 25 CFR 170.231 - May a tribe challenge the data BIA uses in the RNDF?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... challenge the data BIA uses in the RNDF? (a) A tribe may submit a request to the BIA Regional Director to... submit a data correction request at any time. In order to impact the distribution in a given fiscal year... prior fiscal year. (c) The BIA Regional Director must respond within 30 days of receiving a data...

  3. 25 CFR 170.231 - May a tribe challenge the data BIA uses in the RNDF?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... challenge the data BIA uses in the RNDF? (a) A tribe may submit a request to the BIA Regional Director to... submit a data correction request at any time. In order to impact the distribution in a given fiscal year... prior fiscal year. (c) The BIA Regional Director must respond within 30 days of receiving a data...

  4. 25 CFR 170.231 - May a tribe challenge the data BIA uses in the RNDF?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... challenge the data BIA uses in the RNDF? (a) A tribe may submit a request to the BIA Regional Director to... submit a data correction request at any time. In order to impact the distribution in a given fiscal year... prior fiscal year. (c) The BIA Regional Director must respond within 30 days of receiving a data...

  5. 25 CFR 170.231 - May a tribe challenge the data BIA uses in the RNDF?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... challenge the data BIA uses in the RNDF? (a) A tribe may submit a request to the BIA Regional Director to... submit a data correction request at any time. In order to impact the distribution in a given fiscal year... prior fiscal year. (c) The BIA Regional Director must respond within 30 days of receiving a data...

  6. 25 CFR 900.96 - How can Indian tribes or tribal organizations learn about BIA and IHS excess property?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false How can Indian tribes or tribal organizations learn about BIA and IHS excess property? 900.96 Section 900.96 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Property § 900.96 How can Indian tribes or tribal organizations learn about BIA and IHS excess property...

  7. 25 CFR 900.96 - How can Indian tribes or tribal organizations learn about BIA and IHS excess property?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false How can Indian tribes or tribal organizations learn about BIA and IHS excess property? 900.96 Section 900.96 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Property § 900.96 How can Indian tribes or tribal organizations learn about BIA and IHS excess property...

  8. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  9. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  10. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  11. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  12. 25 CFR 166.901 - How will the BIA select an agriculture intern?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the BIA select an agriculture intern? 166.901... PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.901 How will the BIA select an agriculture intern? (a) The purpose of the agriculture intern program is to ensure the future...

  13. 25 CFR 161.5 - Can BIA waive the application of this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA waive the application of this part? 161.5 Section 161.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Definitions, Authority, Purpose, and Scope § 161.5 Can BIA waive the application...

  14. 25 CFR 161.5 - Can BIA waive the application of this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can BIA waive the application of this part? 161.5 Section 161.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Definitions, Authority, Purpose, and Scope § 161.5 Can BIA waive the application...

  15. Resistivity and phase in localized BIA

    NASA Astrophysics Data System (ADS)

    Shiffman, C. A.; Aaron, R.; Amoss, V.; Therrien, J.; Coomler, K.

    1999-10-01

    We describe a system for highly reproducible non-invasive rf impedance measurements as a function of position along body segments such as the thigh. Results are reported for mainly healthy male and female subjects ranging in age from 19 to 65 and in body-mass index from 15 to 40. A principal conclusion is that the phase of the impedance falls monotonically with increasing distance from the knee, with average values substantially above what is found using standard, whole-body bioelectrical impedance analysis (BIA). To compensate for thigh shape, the data are further analysed using an anatomical model based on reasonable approximations for the distributions of muscle, fat and bone, yielding values of the effective resistivity for current flow parallel to the muscle fibres. The phase and resistivity results are discussed with reference to the whole-body BIA study of maintenance haemodialysis patients by Chertow et al, and in regard to possible physiological correlations observed in this work.

  16. 25 CFR 162.524 - Will BIA require a valuation for a WEEL?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will BIA require a valuation for a WEEL? 162.524 Section 162.524 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Monetary Compensation Requirements § 162.524 Will BIA require a...

  17. 25 CFR 162.524 - Will BIA require a valuation for a WEEL?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will BIA require a valuation for a WEEL? 162.524 Section 162.524 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Monetary Compensation Requirements § 162.524 Will BIA require a...

  18. Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

    PubMed

    Grunze, Heinz; Kotlik, Eduardo; Costa, Raquel; Nunes, Teresa; Falcão, Amílcar; Almeida, Luis; Soares-da-Silva, Patrício

    2015-03-15

    Eslicarbazepine acetate (ESL) is an anticonvulsant approved as an adjunctive therapy in adults with partial-onset seizures. To evaluate the efficacy, safety and tolerability of ESL in the treatment of acute mania and prevention of recurrence in bipolar disorder I. Two 3-week multicentre, double-blind, randomised, placebo-controlled studies in acute mania (study BIA-2093-203: dose titrated by response, ESL 600-1800mg or 800-2400mg, once-daily; study BIA-2093-204: fixed doses of 600, 1200 and 1800mg, once-daily) were followed by a recurrence prevention study consisting of a 2-week open-label period (900mg, once-daily) continued by a double-blind, parallel-group, fixed dose (300, 900 and 1800mg, once-daily) period for a minimum of 6 months. The primary endpoint was changed from baseline until the end of the 3-week treatment period in Young Mania Rating Scale (YMRS) in studies BIA-2093-203 and BIA-2093-204, and the proportion of patients showing no worsening according to the Clinical Global Impressions - Bipolar Version (CGI-BP) over Part II in study BIA-2093-205. In study BIA-2093-203 (n=160, ITT), neither dose group was statistically different from placebo in the primary endpoint, though the ESL 800-2400mg showed a greater reduction in YMRS score (p=0.0523). CGI-BP score changes for mania and overall bipolar illness indicate a significant improvement in patient symptomatology for the ESL 800-2400mg group (from preceding and worst phase) and for ESL 600-1800mg group (from worst phase only) when compared to placebo. Study BIA-2093-204 (n=38) results were inconclusive due to premature termination caused by recruitment difficulties. In study BIA-2093-205 (n=85, ITT), at least 50% of patients showed no worsening in all treatment groups (p=0.250). ESL adverse events were mostly of mild and moderate intensities and consistent with previously reported observations for ESL. ESL treatment was not significantly different from placebo in manic patients in the primary outcome

  19. 25 CFR 115.426 - What is the BIA's responsibility regarding the management of a minor's supervised account?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the BIA's responsibility regarding the management...: Minors § 115.426 What is the BIA's responsibility regarding the management of a minor's supervised account? The BIA's responsibility in regard to the management of a minor's supervised account is to: (a...

  20. Detection of muscle gap by L-BIA in muscle injuries: clinical prognosis.

    PubMed

    Nescolarde, L; Yanguas, J; Terricabras, J; Lukaski, H; Alomar, X; Rosell-Ferrer, J; Rodas, G

    2017-06-21

    Sport-related muscle injury classifications are based basically on imaging criteria such as ultrasound (US) and magnetic resonance imaging (MRI) without consensus because of a lack of clinical prognostics for return-to-play (RTP), which is conditioned upon the severity of the injury, and this in turn with the muscle gap (muscular fibers retraction). Recently, Futbol Club Barcelona's medical department proposed a new muscle injury classification in which muscle gap plays an important role, with the drawback that it is not always possible to identify by MRI. Localized bioimpedance measurement (L-BIA) has emerged as a non-invasive technique for supporting US and MRI to quantify the disrupted soft tissue structure in injured muscles. To correlate the severity of the injury according to the gap with the RTP, through the percent of change in resistance (R), reactance (Xc) and phase-angle (PA) by L-BIA measurements in 22 muscle injuries. After grouping the data according to the muscle gap (by MRI exam), there were significant differences in R between grade 1 and grade 2f (myotendinous or myofascial muscle injury with feather-like appearance), as well as between grade 2f and grade 2g (myotendinous or myofascial muscle injury with feather and gap). The Xc and PA values decrease significantly between each grade (i.e. 1 versus 2f, 1 versus 2g and 2f versus 2g). In addition, the severity of the muscle gap adversely affected the RTP with significant differences observed between 1 and 2g as well as between 2f and 2g. These results show that L-BIA could aid MRI and US in identifying the severity of an injured muscle according to muscle gap and therefore to accurately predict the RTP.

  1. 25 CFR 170.614 - Can a tribe receive funds before BIA publishes the notice of funding availability?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe receive funds before BIA publishes the notice... Contracts and Agreements Under Isdeaa § 170.614 Can a tribe receive funds before BIA publishes the notice of funding availability? A tribe can receive funds before BIA publishes the notice of funding availability...

  2. 25 CFR 161.711 - How will BIA sell impounded livestock or other property?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will BIA sell impounded livestock or other property? 161.711 Section 161.711 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.711 How will BIA sell impounded livestock...

  3. 25 CFR 161.711 - How will BIA sell impounded livestock or other property?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will BIA sell impounded livestock or other property? 161.711 Section 161.711 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.711 How will BIA sell impounded livestock...

  4. 25 CFR 161.711 - How will BIA sell impounded livestock or other property?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA sell impounded livestock or other property? 161.711 Section 161.711 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.711 How will BIA sell impounded livestock...

  5. 25 CFR 161.711 - How will BIA sell impounded livestock or other property?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA sell impounded livestock or other property? 161.711 Section 161.711 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.711 How will BIA sell impounded livestock...

  6. 25 CFR 161.711 - How will BIA sell impounded livestock or other property?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will BIA sell impounded livestock or other property? 161.711 Section 161.711 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.711 How will BIA sell impounded livestock...

  7. 25 CFR 162.516 - How will BIA enforce removal requirements in a WEEL?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA enforce removal requirements in a WEEL? 162.516 Section 162.516 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weels § 162.516 How will BIA enforce removal requirements...

  8. 25 CFR 162.516 - How will BIA enforce removal requirements in a WEEL?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA enforce removal requirements in a WEEL? 162.516 Section 162.516 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weels § 162.516 How will BIA enforce removal requirements...

  9. 25 CFR 162.531 - How will BIA decide whether to approve a WEEL?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve a WEEL? 162.531 Section 162.531 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Approval § 162.531 How will BIA decide whether to approve a...

  10. 25 CFR 162.531 - How will BIA decide whether to approve a WEEL?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve a WEEL? 162.531 Section 162.531 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Approval § 162.531 How will BIA decide whether to approve a...

  11. Occurrence and metabolism of 7-hydroxy-2-indolinone-3-acetic acid in Zea mays

    NASA Technical Reports Server (NTRS)

    Lewer, P.; Bandurski, R. S.

    1987-01-01

    7-Hydroxy-2-indolinone-3-acetic acid was identified as a catabolite of indole-3-acetic acid in germinating kernels of Zea mays and found to be present in amounts of ca 3.1 nmol/kernel. 7-Hydroxy-2-indolinone-3-acetic acid was shown to be a biosynthetic intermediate between 2-indolinone-3-acetic acid and 7-hydroxy-2-indolinone-3-acetic acid-7'-O-glucoside in both kernels and roots of Zea mays. Further metabolism of 7-hydroxy-2-[5-3H]-indolinone-3-acetic acid-7'-O-glucoside occurred to yield tritiated water plus, as yet, uncharacterized products.

  12. 25 CFR 15.203 - What information must tribes provide BIA to complete the probate file?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What information must tribes provide BIA to complete the... the Probate File § 15.203 What information must tribes provide BIA to complete the probate file... pending probate matter. ...

  13. Aqueous-Phase Acetic Acid Ketonization over Monoclinic Zirconia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cai, Qiuxia; Lopez-Ruiz, Juan A.; Cooper, Alan R.

    The effect of aqueous phase on the acetic acid ketonization over monoclinic zirconia has been investigated using first-principles based density functional theory (DFT) calculations. To capture the aqueous phase chemistry over the solid zirconia catalyst surface, the aqueous phase is represented by 111 explicit water molecules with a liquid water density of 0.93 g/cm3 and the monoclinic zirconia is modeled by the most stable surface structure . The dynamic nature of aqueous phase/ interface was studied using ab initio molecular dynamics simulation, indicating that nearly half of the surface Zr sites are occupied by either adsorbed water molecules or hydroxylmore » groups at 550 K. DFT calculations show that the adsorption process of acetic acid from the liquid water phase to the surface is nearly thermodynamically neutral with a Gibbs free energy of -2.3 kJ/mol although the adsorption strength of acetic acid on the surface in aqueous phase is much stronger than in vapor phase. Therefore it is expected that the adsorption of acetic acid will dramatically affects aqueous phase ketonization reactivity over the monoclinic zirconia catalyst. Using the same ketonization mechanism via the β-keto acid intermediate, we have compared acetic acid ketonization to acetone in both vapor and aqueous phases. Our DFT calculation results show although the rate-determining step of the β-keto acid formation via the C-C coupling is not pronouncedly affected, the presence of liquid water molecules will dramatically affect dehydrogenation and hydrogenation steps via proton transfer mechanism. This work was financially supported by the United States Department of Energy (DOE)’s Bioenergy Technologies Office (BETO) and performed at the Pacific Northwest National Laboratory (PNNL). PNNL is a multi-program national laboratory operated for DOE by Battelle Memorial Institute. Computing time and advanced catalyst characterization use was granted by a user proposal at the William R. Wiley

  14. Smart Multi-Frequency Bioelectrical Impedance Spectrometer for BIA and BIVA Applications.

    PubMed

    Harder, Rene; Diedrich, Andre; Whitfield, Jonathan S; Buchowski, Macie S; Pietsch, John B; Baudenbacher, Franz J

    2016-08-01

    Bioelectrical impedance analysis (BIA) is a noninvasive and commonly used method for the assessment of body composition including body water. We designed a small, portable and wireless multi-frequency impedance spectrometer based on the 12 bit impedance network analyzer AD5933 and a precision wide-band constant current source for tetrapolar whole body impedance measurements. The impedance spectrometer communicates via Bluetooth with mobile devices (smart phone or tablet computer) that provide user interface for patient management and data visualization. The export of patient measurement results into a clinical research database facilitates the aggregation of bioelectrical impedance analysis and biolectrical impedance vector analysis (BIVA) data across multiple subjects and/or studies. The performance of the spectrometer was evaluated using a passive tissue equivalent circuit model as well as a comparison of body composition changes assessed with bioelectrical impedance and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Our results show an absolute error of 1% for resistance and 5% for reactance measurements in the frequency range of 3 kHz to 150 kHz. A linear regression of BIA and DXA fat mass estimations showed a strong correlation (r(2)=0.985) between measures with a maximum absolute error of 6.5%. The simplicity of BIA measurements, a cost effective design and the simple visual representation of impedance data enables patients to compare and determine body composition during the time course of a specific treatment plan in a clinical or home environment.

  15. Ulipristal acetate versus leuprolide acetate for uterine fibroids.

    PubMed

    Donnez, Jacques; Tomaszewski, Janusz; Vázquez, Francisco; Bouchard, Philippe; Lemieszczuk, Boguslav; Baró, Francesco; Nouri, Kazem; Selvaggi, Luigi; Sodowski, Krzysztof; Bestel, Elke; Terrill, Paul; Osterloh, Ian; Loumaye, Ernest

    2012-02-02

    The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear. In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy with oral ulipristal acetate (at a dose of either 5 mg or 10 mg) or once-monthly intramuscular injections of leuprolide acetate (at a dose of 3.75 mg). The primary outcome was the proportion of patients with controlled bleeding at week 13, with a prespecified noninferiority margin of -20%. Uterine bleeding was controlled in 90% of patients receiving 5 mg of ulipristal acetate, in 98% of those receiving 10 mg of ulipristal acetate, and in 89% of those receiving leuprolide acetate, for differences (as compared with leuprolide acetate) of 1.2 percentage points (95% confidence interval [CI], -9.3 to 11.8) for 5 mg of ulipristal acetate and 8.8 percentage points (95% CI, 0.4 to 18.3) for 10 mg of ulipristal acetate. Median times to amenorrhea were 7 days for patients receiving 5 mg of ulipristal acetate, 5 days for those receiving 10 mg of ulipristal acetate, and 21 days for those receiving leuprolide acetate. Moderate-to-severe hot flashes were reported for 11% of patients receiving 5 mg of ulipristal acetate, for 10% of those receiving 10 mg of ulipristal acetate, and for 40% of those receiving leuprolide acetate (P<0.001 for each dose of ulipristal acetate vs. leuprolide acetate). Both the 5-mg and 10-mg daily doses of ulipristal acetate were noninferior to once-monthly leuprolide acetate in controlling uterine bleeding and were significantly less likely to cause hot flashes. (Funded by PregLem; ClinicalTrials.gov number, NCT00740831.).

  16. 23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available funding...

  17. 23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available funding...

  18. 25 CFR 1000.123 - Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such terms as the parties may negotiate? 1000.123 Section 1000... there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such...

  19. 25 CFR 1000.123 - Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such terms as the parties may negotiate? 1000.123 Section 1000... there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such...

  20. 25 CFR 1000.123 - Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such terms as the parties may negotiate? 1000.123 Section 1000... there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such...

  1. 25 CFR 1000.123 - Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such terms as the parties may negotiate? 1000.123 Section 1000... there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such...

  2. 25 CFR 1000.123 - Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Are there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such terms as the parties may negotiate? 1000.123 Section 1000... there non-BIA programs for which the Secretary must negotiate for inclusion in an AFA subject to such...

  3. 25 CFR 162.598 - When will BIA issue a decision on an appeal from a WSR leasing decision?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false When will BIA issue a decision on an appeal from a WSR leasing decision? 162.598 Section 162.598 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR..., and Enforcement § 162.598 When will BIA issue a decision on an appeal from a WSR leasing decision? BIA...

  4. 25 CFR 162.598 - When will BIA issue a decision on an appeal from a WSR leasing decision?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false When will BIA issue a decision on an appeal from a WSR leasing decision? 162.598 Section 162.598 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR..., and Enforcement § 162.598 When will BIA issue a decision on an appeal from a WSR leasing decision? BIA...

  5. 25 CFR 115.427 - What is the BIA's annual review process for a minor's supervised account?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the BIA's annual review process for a minor's supervised account? A BIA social worker with an MSW will... reports and notes; (d) Reviewing account records to insure that withdrawals and payments were made in...

  6. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

    PubMed

    Chen, Rui; Xu, Min; Nagati, Jason S; Hogg, Richard T; Das, Alok; Gerard, Robert D; Garcia, Joseph A

    2015-01-01

    Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by CBP also requires a specific acetyl CoA generator, acetate-dependent acetyl CoA synthetase 2 (ACSS2). In this study, we demonstrate that ACSS2/HIF-2 signaling is active not only during hypoxia, but also during glucose deprivation. Acetate levels increase during stress and coincide with maximal HIF-2α acetylation and CBP/HIF-2α complex formation. Exogenous acetate induces HIF-2α acetylation, CBP/HIF-2α complex formation, and HIF-2 signaling. ACSS2 and HIF-2 are required for maximal colony formation, proliferation, migration, and invasion during stress. Acetate also stimulates flank tumor growth and metastasis in mice in an ACSS2 and HIF-2 dependent manner. Thus, ACSS2/CBP/SIRT1/HIF-2 signaling links nutrient sensing and stress signaling with cancer growth and progression in mammals.

  7. The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

    PubMed Central

    Chen, Rui; Xu, Min; Nagati, Jason S.; Hogg, Richard T.; Das, Alok; Gerard, Robert D.; Garcia, Joseph A.

    2015-01-01

    Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by CBP also requires a specific acetyl CoA generator, acetate-dependent acetyl CoA synthetase 2 (ACSS2). In this study, we demonstrate that ACSS2/HIF-2 signaling is active not only during hypoxia, but also during glucose deprivation. Acetate levels increase during stress and coincide with maximal HIF-2α acetylation and CBP/HIF-2α complex formation. Exogenous acetate induces HIF-2α acetylation, CBP/HIF-2α complex formation, and HIF-2 signaling. ACSS2 and HIF-2 are required for maximal colony formation, proliferation, migration, and invasion during stress. Acetate also stimulates flank tumor growth and metastasis in mice in an ACSS2 and HIF-2 dependent manner. Thus, ACSS2/CBP/SIRT1/HIF-2 signaling links nutrient sensing and stress signaling with cancer growth and progression in mammals. PMID:25689462

  8. 25 CFR 162.545 - How will BIA enforce removal requirements in a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA enforce removal requirements in a WSR lease? 162.545 Section 162.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.545 How will BIA enforce removal...

  9. 25 CFR 162.545 - How will BIA enforce removal requirements in a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA enforce removal requirements in a WSR lease? 162.545 Section 162.545 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.545 How will BIA enforce removal...

  10. Rapid degradation of 2,4-dichlorophenoxyacetic acid facilitated by acetate under methanogenic condition.

    PubMed

    Yang, Zhiman; Xu, Xiaohui; Dai, Meng; Wang, Lin; Shi, Xiaoshuang; Guo, Rongbo

    2017-05-01

    Acetate can be used as an electron donor to stimulate 2,4-dichlorophenoxyacetic acid (2,4-D), which has not been determined under methanogenic condition. This study applied high-throughput sequencing and methanogenic inhibition approaches to investigate the 2,4-D degradation process using the enrichments obtained from paddy soil. Acetate addition significantly promoted 2,4-D degradation, which was 5-fold higher than in the acetate-unsupplemented enrichments in terms of the 2,4-D degradation rate constant. Dechloromonas and Pseudomonas were the dominant 2,4-D degraders. Methanogenic inhibition experiments indicated that the 2,4-D degradation was independent of methanogenesis. It was proposed that the accelerated 2,4-D degradation in the acetate-supplemented enrichment involved an unusual interaction, where members of the acetate oxidizers primarily oxidized acetate and produced H 2 . H 2 was utilized by the 2,4-D degraders to degrade 2,4-D, but also partially consumed by the hydrogenotrophic methanogens to produce methane. The findings presented here provide a new strategy for the remediation of 2,4-D-polluted soils. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. 25 CFR 162.566 - How will BIA decide whether to approve a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve a WSR lease? 162.566 Section 162.566 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Approval § 162.566 How will BIA decide whether to...

  12. 25 CFR 162.566 - How will BIA decide whether to approve a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve a WSR lease? 162.566 Section 162.566 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Approval § 162.566 How will BIA decide whether to...

  13. 25 CFR 171.310 - Can I use water delivered by BIA for livestock purposes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I use water delivered by BIA for livestock purposes? 171.310 Section 171.310 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.310 Can I use water delivered by BIA for livestock purposes? Yes, if we determine it will not: (...

  14. 25 CFR 171.310 - Can I use water delivered by BIA for livestock purposes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can I use water delivered by BIA for livestock purposes? 171.310 Section 171.310 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.310 Can I use water delivered by BIA for livestock purposes? Yes, if we determine it will not: (...

  15. Low-field induced large magnetocaloric effect in Tm2Ni0.93Si2.93: influence of short-range magnetic correlation

    NASA Astrophysics Data System (ADS)

    Pakhira, Santanu; Mazumdar, Chandan; Ranganathan, R.

    2017-12-01

    In this work, we report the successful synthesis of a new intermetallic compound Tm2 Ni0.93 Si2.93 that forms in single phase only in defect crystal structure. The compound does not show any long range magnetic ordering down to 2 K. The material exhibits a large magnetic entropy change (-Δ S_M˜13.7 J kg-1 K-1) and adiabatic temperature change (Δ T_ad˜4.4 K) at 2.2 K for a field change of 20 kOe which can be realized by permanent magnets, thus being very beneficial for application purpose. In the absence of long-range magnetic ordering down to 2 K, the metastable nature of low-temperature spin dynamics and short-range magnetic correlations are considered to be responsible for such a large magnetocaloric effect over a wide temperature region.

  16. 25 CFR 170.600 - What must BIA include in the notice of availability of funds?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must BIA include in the notice of availability of... WATER INDIAN RESERVATION ROADS PROGRAM Service Delivery for Indian Reservation Roads Funding Process § 170.600 What must BIA include in the notice of availability of funds? (a) Upon receiving the total...

  17. 25 CFR 15.203 - What information must Tribes provide BIA to complete the probate file?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What information must Tribes provide BIA to complete the... the Probate File § 15.203 What information must Tribes provide BIA to complete the probate file... pending probate matter, and a copy of Tribal probate orders where they exist. [76 FR 7505, Feb. 10, 2011] ...

  18. 25 CFR 171.310 - Can I use water delivered by BIA for livestock purposes?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Can I use water delivered by BIA for livestock purposes? 171.310 Section 171.310 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Water Use § 171.310 Can I use water delivered by BIA for livestock purposes? Yes, if we determine it will not: (a...

  19. Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid.

    PubMed

    Zhang, Mingming; Zhang, Keyu; Mehmood, Muhammad Aamer; Zhao, Zongbao Kent; Bai, Fengwu; Zhao, Xinqing

    2017-12-01

    The aim of this work was to study the effects of deleting acetate transporter gene ADY2 on growth and fermentation of Saccharomyces cerevisiae in the presence of inhibitors. Comparative transcriptome analysis revealed that three genes encoding plasma membrane carboxylic acid transporters, especially ADY2, were significantly downregulated under the zinc sulfate addition condition in the presence of acetic acid stress, and the deletion of ADY2 improved growth of S. cerevisiae under acetic acid, ethanol and hydrogen peroxide stresses. Consistently, a concomitant increase in ethanol production by 14.7% in the presence of 3.6g/L acetic acid was observed in the ADY2 deletion mutant of S. cerevisiae BY4741. Decreased intracellular acetic acid, ROS accumulation, and plasma membrane permeability were observed in the ADY2 deletion mutant. These findings would be useful for developing robust yeast strains for efficient ethanol production. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. 25 CFR 170.807 - What must BIA include when it develops an IRR Transportation Facilities Maintenance Management...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Transportation Facilities Maintenance Management System? 170.807 Section 170.807 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.807 What must BIA include when it develops an IRR Transportation Facilities Maintenance Management System...

  1. BIA Wingate High School WWTF, Fort Wingate, NM: NN0020958

    EPA Pesticide Factsheets

    NPDES Permit and Fact Sheet explaining EPA's action under the Clean Water Act to issue NPDES Permit No. NN0020958 to Bureau of Indian Affairs (BIA) Wingate High School Wastewater Treatment Lagoon, Fort Wingate, NM.

  2. Pulsed (13)C2-Acetate Protein-SIP Unveils Epsilonproteobacteria as Dominant Acetate Utilizers in a Sulfate-Reducing Microbial Community Mineralizing Benzene.

    PubMed

    Starke, Robert; Keller, Andreas; Jehmlich, Nico; Vogt, Carsten; Richnow, Hans H; Kleinsteuber, Sabine; von Bergen, Martin; Seifert, Jana

    2016-05-01

    In a benzene-degrading and sulfate-reducing syntrophic consortium, a clostridium affiliated to the genus Pelotomaculum was previously described to ferment benzene while various sulfate-reducing Deltaproteobacteria and a member of the Epsilonproteobacteria were supposed to utilize acetate and hydrogen as key metabolites derived from benzene fermentation. However, the acetate utilization network within this community was not yet unveiled. In this study, we performed a pulsed (13)C2-acetate protein stable isotope probing (protein-SIP) approach continuously spiking low amounts of acetate (10 μM per day) in addition to the ongoing mineralization of unlabeled benzene. Metaproteomics revealed high abundances of Clostridiales followed by Syntrophobacterales, Desulfobacterales, Desulfuromonadales, Desulfovibrionales, Archaeoglobales, and Campylobacterales. Pulsed acetate protein-SIP results indicated that members of the Campylobacterales, the Syntrophobacterales, the Archaeoglobales, the Clostridiales, and the Desulfobacterales were linked to acetate utilization in descending abundance. The Campylobacterales revealed the fastest and highest (13)C incorporation. Previous experiments suggested that the activity of the Campylobacterales was not essential for anaerobic benzene degradation in the investigated community. However, these organisms were consistently detected in various hydrocarbon-degrading and sulfate-reducing consortia enriched from the same aquifer. Here, we demonstrate that this member of the Campylobacterales is the dominant acetate utilizer in the benzene-degrading microbial consortium.

  3. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.68 May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its...

  4. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.68 May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its...

  5. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.68 May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its...

  6. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.68 May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its...

  7. Pulmonary and percutaneous absorption of 2-propoxyethyl acetate and 2-ethoxyethyl acetate in beagle dogs.

    PubMed Central

    Guest, D; Hamilton, M L; Deisinger, P J; DiVincenzo, G D

    1984-01-01

    A comparison was made of the absorption and elimination rates of 2-propoxyethyl acetate (PEA) and 2-ethoxyethyl acetate (EEA) following inhalation, dermal application or IV administration. Male beagle dogs were exposed to 50 ppm PEA or EEA for 5 hr, and breath samples were collected during the exposure and a 3-hr recovery period. Both compounds were rapidly absorbed through the lungs. After 10 min of exposure, the concentrations of the parent compounds in the expired breath were 5 to 10 ppm (80-90% absorption) and reached plateau values at about 3 hr of 13 ppm for PEA (74% absorption) and 16 ppm for EEA (68% absorption). Post-exposure breath samples declined exponentially to 0.5 ppm and 2 ppm after 3 hr for PEA and EEA, respectively. Expired concentrations of PEA were slightly, but significantly (p less than 0.025), lower than those of EEA at corresponding times during the exposure. After IV dosing with 1 mg/kg [ethyl-1,2-14C]PEA, the urine contained 61% and 88% of the dose in 4 and 24 hr, respectively. [14C]EEA was eliminated more slowly, with 20% and 61% of the dose appearing in the urine in 4 and 24 hr, respectively. Blood elimination half-lives were 1.6 hr for [14C]PEA and 7.9 hr for [14C]EEA. Only trace amounts of 14CO2 (less than 1%) or volatile materials (less than 0.1%) were detected in the expired air with either compound. For studies of percutaneous absorption, [14C]PEA or [14C]EEA was added to undiluted compound and applied in a glass cell to a shaved area on a dog's thorax for 30 or 60 min.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:6499802

  8. Response of anaerobes to methyl fluoride, 2-bromoethanesulfonate and hydrogen during acetate degradation.

    PubMed

    Hao, Liping; Lü, Fan; Li, Lei; Shao, Liming; He, Pinjing

    2013-05-01

    To use the selective inhibition method for quantitative analysis of acetate metabolism in methanogenic systems, the responses of microbial communities and metabolic activities, which were involved in anaerobic degradation of acetate, to the addition of methyl fluoride (CH3F), 2-bromoethanesulfonate (BES) and hydrogen were investigated in a thermophilic batch experiment. Both the methanogenic inhibitors, i.e., CH3F and BES, showed their effectiveness on inhibiting CH4 production, whereas acetate metabolism other than acetoclastic methanogenesis was stimulated by BES, as reflected by the fluctuated acetate concentration. Syntrophic acetate oxidation was thermodynamically blocked by hydrogen (H2), while H2-utilizing reactions as hydrogenotrophic methanogenesis and homoacetogenesis were correspondingly promoted. Results of PCR-DGGE fingerprinting showed that, CH3F did not influence the microbial populations significantly. However, the BES and hydrogen notably altered the bacterial community structures and increased the diversity. BES gradually changed the methanogenic community structure by affecting the existence of different populations to different levels, whilst H2 greatly changed the abundance of different methanogenic populations, and induced growth of new species.

  9. 25 CFR 103.39 - When will BIA refuse to pay all or part of a lender's claim?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to liquidate loan collateral, and: (1) The lender has not made a reasonable effort to liquidate all... from collateral liquidation proceeds applied to the loan balance; or (e) The lender has otherwise... ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY Default and Payment by BIA § 103.39 When will BIA...

  10. Conversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies.

    PubMed

    Sperling, Michael R; French, Jacqueline; Jacobson, Mercedes P; Pazdera, Ladislav; Gough, Mallory; Cheng, Hailong; Grinnell, Todd; Blum, David

    2016-03-22

    To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%-26.8%); ESL 1,200 mg = 30.8% (23.0%-40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. © 2016 American Academy of Neurology.

  11. 25 CFR 170.701 - May a direct service tribe and BIA Region sign a Memorandum of Understanding?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true May a direct service tribe and BIA Region sign a... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Program Oversight and Accountability § 170.701 May a direct service tribe and BIA Region sign a Memorandum of Understanding? Yes. An IRR Program tribal...

  12. 25 CFR 170.701 - May a direct service tribe and BIA Region sign a Memorandum of Understanding?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false May a direct service tribe and BIA Region sign a... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Program Oversight and Accountability § 170.701 May a direct service tribe and BIA Region sign a Memorandum of Understanding? Yes. An IRR Program tribal...

  13. 25 CFR 170.701 - May a direct service tribe and BIA Region sign a Memorandum of Understanding?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false May a direct service tribe and BIA Region sign a... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Program Oversight and Accountability § 170.701 May a direct service tribe and BIA Region sign a Memorandum of Understanding? Yes. An IRR Program tribal...

  14. 25 CFR 170.701 - May a direct service tribe and BIA Region sign a Memorandum of Understanding?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false May a direct service tribe and BIA Region sign a... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Program Oversight and Accountability § 170.701 May a direct service tribe and BIA Region sign a Memorandum of Understanding? Yes. An IRR Program tribal...

  15. 25 CFR 170.701 - May a direct service tribe and BIA Region sign a Memorandum of Understanding?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false May a direct service tribe and BIA Region sign a... INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Program Oversight and Accountability § 170.701 May a direct service tribe and BIA Region sign a Memorandum of Understanding? Yes. An IRR Program tribal...

  16. Selective Hydrogenolysis of Furfural Derivative 2-Methyltetrahydrofuran into Pentanediol Acetate and Pentanol Acetate over Pd/C and Sc(OTf)3 Cocatalytic System.

    PubMed

    Zhang, Kun; Li, Xing-Long; Chen, Shi-Yan; Xu, Hua-Jian; Deng, Jin; Fu, Yao

    2018-02-22

    It is of great significance to convert platform molecules and their derivatives into high value-added alcohols, which have multitudinous applications. This study concerns systematic conversion of 2-methyltetrahydrofuran (MTHF), which is obtained from furfural, into 1-pentanol acetate (PA) and 1,4-pentanediol acetate (PDA). Reaction parameters, such as the Lewis acid species, reaction temperature, and hydrogen pressure, were investigated in detail. 1 H NMR spectroscopy and reaction dynamics study were also conducted to help clarify the reaction mechanism. Results suggested that cleavage of the primary alcohol acetate was less facile than that of the secondary alcohol acetate, with the main product being PA. A PA yield of 91.8 % (150 °C, 3 MPa H 2 , 30 min) was achieved by using Pd/C and Sc(OTf) 3 as a cocatalytic system and an 82 % yield of PDA was achieved (150 °C, 30 min) by using Sc(OTf) 3 catalyst. Simultaneously, the efficient conversion of acetic esters into alcohols by simple saponification was carried out and led to a good yield. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. 25 CFR 166.815 - How will the BIA determine the amount of damages to Indian agricultural land?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will the BIA determine the amount of damages to Indian agricultural land? 166.815 Section 166.815 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.815 How will the BIA...

  18. 25 CFR 166.815 - How will the BIA determine the amount of damages to Indian agricultural land?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will the BIA determine the amount of damages to Indian agricultural land? 166.815 Section 166.815 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.815 How will the BIA...

  19. 25 CFR 166.815 - How will the BIA determine the amount of damages to Indian agricultural land?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will the BIA determine the amount of damages to Indian agricultural land? 166.815 Section 166.815 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.815 How will the BIA determine...

  20. 25 CFR 166.815 - How will the BIA determine the amount of damages to Indian agricultural land?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the BIA determine the amount of damages to Indian agricultural land? 166.815 Section 166.815 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.815 How will the BIA...

  1. 25 CFR 166.815 - How will the BIA determine the amount of damages to Indian agricultural land?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the BIA determine the amount of damages to Indian agricultural land? 166.815 Section 166.815 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.815 How will the BIA...

  2. sts093-s-001

    NASA Image and Video Library

    1998-09-01

    STS093-S-001 (September 1998) --- This is the STS-93 mission insignia designed by the crew members. Space shuttle Columbia will carry the Advanced X-ray Astrophysics Facility (AXAF) into low Earth orbit initiating its planned five-year astronomy mission. AXAF is the third of NASA's great observatories, following the Hubble Space Telescope (HST) and the Compton Gamma Ray Observatory (GRO). AXAF will provide scientists and order-of magnitude improvement over current capabilities at X-ray wavelengths. In the words of the crew, "Observations of X-ray emissions from energetic galaxies and clusters, as well as black holes, promise to greatly expand current understanding of the origin and evolution of our universe." The patch depicts AXAF separating from the space shuttle Columbia after a successful deployment. A spiral galaxy is shown in the background as a possible target for AXAF observations. The two flags represent the international crew, consisting of astronauts from both the United States and France. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

  3. Acetate ester production by Chinese yellow rice wine yeast overexpressing the alcohol acetyltransferase-encoding gene ATF2.

    PubMed

    Zhang, J; Zhang, C; Qi, Y; Dai, L; Ma, H; Guo, X; Xiao, D

    2014-11-27

    Acetate ester, which are produced by fermenting yeast cells in an enzyme-catalyzed intracellular reaction, are responsible for the fruity character of fermented alcoholic beverages such as Chinese yellow rice wine. Alcohol acetyltransferase (AATase) is currently believed to be the key enzyme responsible for the production of acetate ester. In order to determine the precise role of the ATF2 gene in acetate ester production, an ATF2 gene encoding a type of AATase was overexpressed and the ability of the mutant to form acetate esters (including ethyl acetate, isoamyl acetate, and isobutyl acetate) was investigated. The results showed that after 5 days of fermentation, the concentrations of ethyl acetate, isoamyl acetate, and isobutyl acetate in yellow rice wines fermented with EY2 (pUC-PIA2K) increased to 137.79 mg/L (an approximate 4.9-fold increase relative to the parent cell RY1), 26.68 mg/L, and 7.60 mg/L, respectively. This study confirms that the ATF2 gene plays an important role in the production of acetate ester production during Chinese yellow rice wine fermentation, thereby offering prospects for the development of yellow rice wine yeast starter strains with optimized ester-producing capabilities.

  4. Discovery of the VHE gamma-ray source HESS J1832-093 in the vicinity of SNR G22.7-0.2

    NASA Astrophysics Data System (ADS)

    HESS Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Clapson, A.-C.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Zabalza, V.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    2015-01-01

    The region around the supernova remnant (SNR) W41 contains several TeV sources and has prompted the HESS Collaboration to perform deep observations of this field of view. This resulted in the discovery of the new very high energy (VHE) source HESS J1832-093, at the position {RA=18^h 32^m 50^s ± 3^s_{stat} ± 2^s_{syst}}, {Dec=-9*deg;22'36" ± 32"}_{stat} ± 20^' '}_{syst} (J2000)}, spatially coincident with a part of the radio shell of the neighbouring remnant G22.7-0.2. The photon spectrum is well described by a power law of index Γ = 2.6 ± 0.3stat ± 0.1syst and a normalization at 1 TeV of Φ _0=(4.8 ± 0.8_stat± 1.0_syst) × 10^{-13} cm ^{-2} s^{-1} TeV^{-1}. The location of the gamma-ray emission on the edge of the SNR rim first suggested a signature of escaping cosmic rays illuminating a nearby molecular cloud. Then a dedicated XMM-Newton observation led to the discovery of a new X-ray point source spatially coincident with the TeV excess. Two other scenarios were hence proposed to identify the nature of HESS J1832-093. Gamma-rays from inverse Compton radiation in the framework of a pulsar wind nebula scenario or the possibility of gamma-ray production within a binary system are therefore also considered. Deeper multiwavelength observations will help to shed new light on this intriguing VHE source.

  5. 25 CFR 166.214 - Will the BIA notify the permittee of any change in land title status?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will the BIA notify the permittee of any change in land... AND WATER GRAZING PERMITS Permit Requirements General Requirements § 166.214 Will the BIA notify the permittee of any change in land title status? Yes. We will notify the permittee if a fee patent is issued or...

  6. 25 CFR 162.581 - How will BIA decide whether to approve a sublease of a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve a sublease of a WSR lease? 162.581 Section 162.581 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Subleases § 162.581 How will BIA...

  7. 25 CFR 162.581 - How will BIA decide whether to approve a sublease of a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve a sublease of a WSR lease? 162.581 Section 162.581 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Subleases § 162.581 How will BIA...

  8. New yellow Ba 0.93Eu 0.07Al 2O 4 phosphor for warm-white light-emitting diodes through single-emitting-center conversion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Xufan; Budai, John D.; Liu, Feng

    2013-01-01

    Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white (i.e., correlated color temperature <4000 K) with good color rendition (i.e., color rendering index >80). However, no single-phosphor, single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’ emission spectrum. Here, we report a new yellow Ba 0.93Eu 0.07Al 2O 4 phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component. Warm-white emissions with correlated color temperature <4000 K and color rendering index >80more » were readily achieved when combining the Ba 0.93Eu 0.07Al 2O 4 phosphor with a blue light-emitting diode (440–470 nm). This study demonstrates that warm-white light-emitting diodes with high color rendition (i.e., color rendering index >80) can be achieved based on single-phosphor, single-emitting-center conversion.« less

  9. Properties of MgB 2 superconductor chemically treated by acetic acid

    NASA Astrophysics Data System (ADS)

    Hušeková, K.; Hušek, I.; Kováč, P.; Kulich, M.; Dobročka, E.; Štrbík, V.

    2010-03-01

    Commercial Alfa Aesar MgB 2 powder was chemically treated by acetic acid with the aim of MgO removing. Single-core MgB 2/Fe ex situ wires have been made by powder-in-tube (PIT) process using the powders treated with different acid concentration. All samples were annealed in argon at 950 °C/0.5 h. Differences in transition temperatures and critical currents of acetic acid treated MgB 2 are related to the normal state resistivity, effective carbon substitution from the organic solvent and the active area fraction (grain-connectivity).

  10. 25 CFR 162.551 - How will BIA determine fair market rental for a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation Requirements § 162.551 How will BIA determine fair market rental for a WSR lease? (a) We will use a market analysis... method; or (2) Use an approved market analysis, appraisal, or other appropriate valuation method from the...

  11. 25 CFR 162.551 - How will BIA determine fair market rental for a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation Requirements § 162.551 How will BIA determine fair market rental for a WSR lease? (a) We will use a market analysis... method; or (2) Use an approved market analysis, appraisal, or other appropriate valuation method from the...

  12. 21 CFR 184.1185 - Calcium acetate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Calcium acetate. 184.1185 Section 184.1185 Food... Specific Substances Affirmed as GRAS § 184.1185 Calcium acetate. (a) Calcium acetate (Ca (C2H3O2)2, CAS Reg. No. 62-54-4), also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It...

  13. 21 CFR 184.1185 - Calcium acetate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Calcium acetate. 184.1185 Section 184.1185 Food... GRAS § 184.1185 Calcium acetate. (a) Calcium acetate (Ca (C2H3O2)2, CAS Reg. No. 62-54-4), also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It may be produced by the...

  14. 21 CFR 184.1185 - Calcium acetate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Calcium acetate. 184.1185 Section 184.1185 Food... Specific Substances Affirmed as GRAS § 184.1185 Calcium acetate. (a) Calcium acetate (Ca (C2H3O2)2, CAS Reg. No. 62-54-4), also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It...

  15. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Transportation Facility Maintenance Program A Appendix A to Subpart G Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance Pt. 170... Transportation Facility Maintenance Program The following activities are eligible for BIA Transportation Facility...

  16. Oxygen relieves the CO2 and acetate dependency of Lactobacillus johnsonii NCC 533.

    PubMed

    Hertzberger, Rosanne Y; Pridmore, R David; Gysler, Christof; Kleerebezem, Michiel; Teixeira de Mattos, M Joost

    2013-01-01

    Oxygen relieves the CO2 and acetate dependency of Lactobacillus johnsonii NCC 533. The probiotic Lactobacillus johnsonii NCC 533 is relatively sensitive to oxidative stress; the presence of oxygen causes a lower biomass yield due to early growth stagnation. We show however that oxygen can also be beneficial to this organism as it relieves the requirement for acetate and CO2 during growth. Both on agar- and liquid-media, anaerobic growth of L. johnsonii NCC 533 requires CO2 supplementation of the gas phase. Switching off the CO2 supply induces growth arrest and cell death. The presence of molecular oxygen overcomes the CO2 dependency. Analogously, L. johnsonii NCC 533 strictly requires media with acetate to sustain anaerobic growth, although supplementation at a level that is 100-fold lower (120 microM) than the concentration in regular growth medium for lactobacilli already suffices for normal growth. Analogous to the CO2 requirement, oxygen supply relieves this acetate-dependency for growth. The L. johnsonii NCC 533 genome indicates that this organism lacks genes coding for pyruvate formate lyase (PFL) and pyruvate dehydrogenase (PDH), both CO2 and acetyl-CoA producing systems. Therefore, C1- and C2- compound production is predicted to largely depend on pyruvate oxidase activity (POX). This proposed role of POX in C2/C1-generation is corroborated by the observation that in a POX deficient mutant of L. johnsonii NCC 533, oxygen is not able to overcome acetate dependency nor does it relieve the CO2 dependency.

  17. Oxygen Relieves the CO2 and Acetate Dependency of Lactobacillus johnsonii NCC 533

    PubMed Central

    Hertzberger, Rosanne Y.; Pridmore, R. David; Gysler, Christof; Kleerebezem, Michiel; Teixeira de Mattos, M. Joost

    2013-01-01

    Oxygen relieves the CO2 and acetate dependency of Lactobacillus johnsonii NCC 533. The probiotic Lactobacillus johnsonii NCC 533 is relatively sensitive to oxidative stress; the presence of oxygen causes a lower biomass yield due to early growth stagnation. We show however that oxygen can also be beneficial to this organism as it relieves the requirement for acetate and CO2 during growth. Both on agar- and liquid-media, anaerobic growth of L. johnsonii NCC 533 requires CO2 supplementation of the gas phase. Switching off the CO2 supply induces growth arrest and cell death. The presence of molecular oxygen overcomes the CO2 dependency. Analogously, L. johnsonii NCC 533 strictly requires media with acetate to sustain anaerobic growth, although supplementation at a level that is 100-fold lower (120 microM) than the concentration in regular growth medium for lactobacilli already suffices for normal growth. Analogous to the CO2 requirement, oxygen supply relieves this acetate-dependency for growth. The L. johnsonii NCC 533 genome indicates that this organism lacks genes coding for pyruvate formate lyase (PFL) and pyruvate dehydrogenase (PDH), both CO2 and acetyl-CoA producing systems. Therefore, C1- and C2- compound production is predicted to largely depend on pyruvate oxidase activity (POX). This proposed role of POX in C2/C1-generation is corroborated by the observation that in a POX deficient mutant of L. johnsonii NCC 533, oxygen is not able to overcome acetate dependency nor does it relieve the CO2 dependency. PMID:23468944

  18. 25 CFR 1000.68 - May non-BIA bureaus provide technical assistance to a Tribe/Consortium in drafting its planning...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application... Tribe/Consortium in drafting its planning grant application? 1000.68 Section 1000.68 Indians OFFICE OF... planning grant application? Yes, upon request from the Tribe/Consortium, a non-BIA bureau may provide...

  19. 25 CFR 161.715 - What will BIA do if a trespasser fails to pay penalties, damages and costs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What will BIA do if a trespasser fails to pay penalties....715 What will BIA do if a trespasser fails to pay penalties, damages and costs? This section applies if a trespasser fails to pay the assessed penalties, damages, and costs as directed. Unless otherwise...

  20. 25 CFR 161.715 - What will BIA do if a trespasser fails to pay penalties, damages and costs?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What will BIA do if a trespasser fails to pay penalties....715 What will BIA do if a trespasser fails to pay penalties, damages and costs? This section applies if a trespasser fails to pay the assessed penalties, damages, and costs as directed. Unless otherwise...

  1. 25 CFR 166.813 - How will the BIA determine the value of forage or crops consumed or destroyed?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will the BIA determine the value of forage or crops consumed or destroyed? 166.813 Section 166.813 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.813 How will the BIA...

  2. 25 CFR 166.813 - How will the BIA determine the value of forage or crops consumed or destroyed?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How will the BIA determine the value of forage or crops consumed or destroyed? 166.813 Section 166.813 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.813 How will the BIA...

  3. 25 CFR 166.813 - How will the BIA determine the value of forage or crops consumed or destroyed?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will the BIA determine the value of forage or crops consumed or destroyed? 166.813 Section 166.813 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.813 How will the BIA...

  4. 25 CFR 166.813 - How will the BIA determine the value of forage or crops consumed or destroyed?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the BIA determine the value of forage or crops consumed or destroyed? 166.813 Section 166.813 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.813 How will the BIA...

  5. 25 CFR 166.813 - How will the BIA determine the value of forage or crops consumed or destroyed?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will the BIA determine the value of forage or crops consumed or destroyed? 166.813 Section 166.813 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.813 How will the BIA...

  6. 25 CFR 171.420 - Can I dispose of sewage, trash, or other refuse on a BIA irrigation project?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I dispose of sewage, trash, or other refuse on a BIA... AND WATER IRRIGATION OPERATION AND MAINTENANCE Irrigation Facilities § 171.420 Can I dispose of sewage, trash, or other refuse on a BIA irrigation project? No. Sewage, trash, or other refuse are considered...

  7. 25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

  8. 25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

  9. 25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

  10. 25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

  11. 25 CFR 115.410 - What types of identification will the BIA or OTFM accept as “verifiable photo identification”?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... as âverifiable photo identificationâ? 115.410 Section 115.410 Indians BUREAU OF INDIAN AFFAIRS...: Minors § 115.410 What types of identification will the BIA or OTFM accept as “verifiable photo identification”? BIA or OTFM will accept the following forms of identification as “verifiable photo...

  12. 25 CFR 166.819 - What happens if the BIA does not collect enough money to satisfy the penalty?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What happens if the BIA does not collect enough money to satisfy the penalty? 166.819 Section 166.819 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.819 What happens if the BIA...

  13. 25 CFR 170.425 - How does BIA update the IRRTIP?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA update the IRRTIP? 170.425 Section 170.425 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Transportation...

  14. Fast BIA-amperometric determination of isoniazid in tablets.

    PubMed

    Quintino, Maria S M; Angnes, Lúcio

    2006-09-26

    This paper proposes a new, fast and precise method to analyze isoniazid based on the electrochemical oxidation of the analyte at a glassy carbon electrode in 0.1M NaOH. The quantification was performed utilizing amperometry associated with batch injection analysis (BIA) technique. Fast sequential analysis (60 determinations h(-1)) in an unusually wide linear dynamic range (from 2.5 x 10(-8) to 1.0 x 10(-3)M), with high sensitivity and low limits of detection (4.1 x 10(-9)M) and quantification (1.4 x 10(-8)M), was achieved. Such characteristics allied to a good repeatability of the current responses (relative standard deviation of 0.79% for 30 measurements), were explored for the specific determination of isoniazid in isoniazid-rifampin tablet.

  15. Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

    DOEpatents

    Hollingsworth, Rawle I.; Wang, Guijun

    2000-01-01

    A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.

  16. 21 CFR 184.1721 - Sodium acetate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Sodium acetate. 184.1721 Section 184.1721 Food and....1721 Sodium acetate. (a) Sodium acetate (C2H3O2Na, CAS Reg. No. 127-09-3 or C2H3O2Na·3H2O, CAS Reg. No. 6131-90-4) is the sodium salt of acetic acid and occurs naturally in plant and animal tissues. Sodium...

  17. Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering

    PubMed Central

    Chen, Yingying; Stabryla, Lisa

    2016-01-01

    Development of acetic acid-resistant Saccharomyces cerevisiae is important for economically viable production of biofuels from lignocellulosic biomass, but the goal remains a critical challenge due to limited information on effective genetic perturbation targets for improving acetic acid resistance in the yeast. This study employed a genomic-library-based inverse metabolic engineering approach to successfully identify a novel gene target, WHI2 (encoding a cytoplasmatic globular scaffold protein), which elicited improved acetic acid resistance in S. cerevisiae. Overexpression of WHI2 significantly improved glucose and/or xylose fermentation under acetic acid stress in engineered yeast. The WHI2-overexpressing strain had 5-times-higher specific ethanol productivity than the control in glucose fermentation with acetic acid. Analysis of the expression of WHI2 gene products (including protein and transcript) determined that acetic acid induced endogenous expression of Whi2 in S. cerevisiae. Meanwhile, the whi2Δ mutant strain had substantially higher susceptibility to acetic acid than the wild type, suggesting the important role of Whi2 in the acetic acid response in S. cerevisiae. Additionally, overexpression of WHI2 and of a cognate phosphatase gene, PSR1, had a synergistic effect in improving acetic acid resistance, suggesting that Whi2 might function in combination with Psr1 to elicit the acetic acid resistance mechanism. These results improve our understanding of the yeast response to acetic acid stress and provide a new strategy to breed acetic acid-resistant yeast strains for renewable biofuel production. PMID:26826231

  18. Crystal structure of [(2R,3R,4S)-3,4-bis(acet-yloxy)-5-iodo-3,4-di-hydro-2H-pyran-2-yl]methyl acetate.

    PubMed

    Zukerman-Schpector, Julio; Caracelli, Ignez; Stefani, Hélio A; Shamim, Anwar; Tiekink, Edward R T

    2015-01-01

    In the title compound, C12H15IO7, the 3,4-di-hydro-2H-pyran ring is in a distorted half-boat conformation with the atom bearing the acet-yloxy group adjacent to the C atom bearing the methyl-acetate group lying 0.633 (6) Å above the plane of the remaining ring atoms (r.m.s. deviation = 0.0907 Å). In the crystal, mol-ecules are linked into a supra-molecular chain along the a axis through two C-H⋯O inter-actions to the same acceptor carbonyl O atom; these chains pack with no specific inter-molecular inter-actions between them.

  19. Reactivity and reaction intermediates for acetic acid adsorbed on CeO 2(111)

    DOE PAGES

    Calaza, Florencia C.; Chen, Tsung -Liang; Mullins, David R.; ...

    2015-05-02

    Adsorption and reaction of acetic acid on a CeO 2(1 1 1) surface was studied by a combination of ultra-highvacuum based methods including temperature desorption spectroscopy (TPD), soft X-ray photoelectronspectroscopy (sXPS), near edge X-ray absorption spectroscopy (NEXAFS) and reflection absorption IRspectroscopy (RAIRS), together with density functional theory (DFT) calculations. TPD shows that thedesorption products are strongly dependent upon the initial oxidation state of the CeO 2 surface, includingselectivity between acetone and acetaldehyde products. The combination of sXPS and NEXAFS demon-strate that acetate forms upon adsorption at low temperature and is stable to above 500 K, above whichpoint ketene, acetone andmore » acetic acid desorb. Furthermore, DFT and RAIRS show that below 500 K, bridge bondedacetate coexists with a moiety formed by adsorption of an acetate at an oxygen vacancy, formed bywater desorption.« less

  20. 25 CFR 162.213 - What supporting documents must be provided prior to BIA's grant or approval of an agricultural...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What supporting documents must be provided prior to BIA's....213 What supporting documents must be provided prior to BIA's grant or approval of an agricultural... organizational and financial documents, as needed to show that the lease will be enforceable against the tenant...

  1. Relationships among dual-energy X-ray absorptiometry (DXA), bioelectrical impedance (BIA), and ultrasound measurements of body composition of swine

    USDA-ARS?s Scientific Manuscript database

    In three separate studies (156 pigs total), DXA, BIA, and ultrasound were compared as methods for measuring live body composition of pigs at 60 and 100-110 kg BWt. DXA measured total body fat and lean content, BIA measurements of resistance (Rs) and reactance (Xc) were used to calculate total body l...

  2. 25 CFR 115.614 - Why is the BIA hearing recorded?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.614 Why is... the hearing process is appealed under § 115.107. The BIA hearing record must be preserved as a trust...

  3. 25 CFR 115.614 - Why is the BIA hearing recorded?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.614 Why is... the hearing process is appealed under § 115.107. The BIA hearing record must be preserved as a trust...

  4. 25 CFR 115.614 - Why is the BIA hearing recorded?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.614 Why is... the hearing process is appealed under § 115.107. The BIA hearing record must be preserved as a trust...

  5. 25 CFR 115.614 - Why is the BIA hearing recorded?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.614 Why is... the hearing process is appealed under § 115.107. The BIA hearing record must be preserved as a trust...

  6. 25 CFR 115.614 - Why is the BIA hearing recorded?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.614 Why is... the hearing process is appealed under § 115.107. The BIA hearing record must be preserved as a trust...

  7. 21 CFR 184.1721 - Sodium acetate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Sodium acetate. 184.1721 Section 184.1721 Food and... Substances Affirmed as GRAS § 184.1721 Sodium acetate. (a) Sodium acetate (C2H3O2Na, CAS Reg. No. 127-09-3 or C2H3O2Na·3H2O, CAS Reg. No. 6131-90-4) is the sodium salt of acetic acid and occurs naturally in plant and...

  8. 21 CFR 184.1721 - Sodium acetate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Sodium acetate. 184.1721 Section 184.1721 Food and... Substances Affirmed as GRAS § 184.1721 Sodium acetate. (a) Sodium acetate (C2H3O2Na, CAS Reg. No. 127-09-3 or C2H3O2Na·3H2O, CAS Reg. No. 6131-90-4) is the sodium salt of acetic acid and occurs naturally in plant and...

  9. 21 CFR 184.1721 - Sodium acetate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Sodium acetate. 184.1721 Section 184.1721 Food and... Substances Affirmed as GRAS § 184.1721 Sodium acetate. (a) Sodium acetate (C2H3O2Na, CAS Reg. No. 127-09-3 or C2H3O2Na·3H2O, CAS Reg. No. 6131-90-4) is the sodium salt of acetic acid and occurs naturally in plant and...

  10. 21 CFR 184.1721 - Sodium acetate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Sodium acetate. 184.1721 Section 184.1721 Food and... Substances Affirmed as GRAS § 184.1721 Sodium acetate. (a) Sodium acetate (C2H3O2Na, CAS Reg. No. 127-09-3 or C2H3O2Na·3H2O, CAS Reg. No. 6131-90-4) is the sodium salt of acetic acid and occurs naturally in plant and...

  11. Design and Development of a Portable WiFi enabled BIA device

    NASA Astrophysics Data System (ADS)

    Križaj, D.; Baloh, M.; Brajkovič, R.; Žagar, T.

    2013-04-01

    A bioimpedance device (BIA) for evaluation of sarcopenia - age related muscle mass loss - is designed, developed and evaluated. The requirements were based on lightweight design, flexible and user enabled incorporation of measurement protocols and WiFi protocol for remote device control, full internet integration and fast development and usage of measurement protocols. The current design is based on usage of a microcontroller with integrated AD/DA converters. The prototype system was assembled and the operation and connectivity to different handheld devices and laptop computers was successfully tested. The designed BIA device can be accessed using TCP sockets and once the connection is established the data transfer runs successfully at the specified speed. The accuracy of currently developed prototype is about 5% for the impedance modulus and 5 deg. for the phase for the frequencies below 20 kHz with an unfiltered excitation signal and no additional amplifiers employed.

  12. Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering.

    PubMed

    Chen, Yingying; Stabryla, Lisa; Wei, Na

    2016-01-29

    Development of acetic acid-resistant Saccharomyces cerevisiae is important for economically viable production of biofuels from lignocellulosic biomass, but the goal remains a critical challenge due to limited information on effective genetic perturbation targets for improving acetic acid resistance in the yeast. This study employed a genomic-library-based inverse metabolic engineering approach to successfully identify a novel gene target, WHI2 (encoding a cytoplasmatic globular scaffold protein), which elicited improved acetic acid resistance in S. cerevisiae. Overexpression of WHI2 significantly improved glucose and/or xylose fermentation under acetic acid stress in engineered yeast. The WHI2-overexpressing strain had 5-times-higher specific ethanol productivity than the control in glucose fermentation with acetic acid. Analysis of the expression of WHI2 gene products (including protein and transcript) determined that acetic acid induced endogenous expression of Whi2 in S. cerevisiae. Meanwhile, the whi2Δ mutant strain had substantially higher susceptibility to acetic acid than the wild type, suggesting the important role of Whi2 in the acetic acid response in S. cerevisiae. Additionally, overexpression of WHI2 and of a cognate phosphatase gene, PSR1, had a synergistic effect in improving acetic acid resistance, suggesting that Whi2 might function in combination with Psr1 to elicit the acetic acid resistance mechanism. These results improve our understanding of the yeast response to acetic acid stress and provide a new strategy to breed acetic acid-resistant yeast strains for renewable biofuel production. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  13. 25 CFR 166.806 - What actions does the BIA take against trespassers?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... GRAZING PERMITS Trespass Actions § 166.806 What actions does the BIA take against trespassers? If the... involved in the trespass. We may keep such property we seize for use as evidence. (b) Assess penalties...

  14. 25 CFR 166.806 - What actions does the BIA take against trespassers?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... GRAZING PERMITS Trespass Actions § 166.806 What actions does the BIA take against trespassers? If the... involved in the trespass. We may keep such property we seize for use as evidence. (b) Assess penalties...

  15. 25 CFR 166.806 - What actions does the BIA take against trespassers?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... GRAZING PERMITS Trespass Actions § 166.806 What actions does the BIA take against trespassers? If the... involved in the trespass. We may keep such property we seize for use as evidence. (b) Assess penalties...

  16. 25 CFR 166.806 - What actions does the BIA take against trespassers?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... GRAZING PERMITS Trespass Actions § 166.806 What actions does the BIA take against trespassers? If the... involved in the trespass. We may keep such property we seize for use as evidence. (b) Assess penalties...

  17. 25 CFR 166.806 - What actions does the BIA take against trespassers?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GRAZING PERMITS Trespass Actions § 166.806 What actions does the BIA take against trespassers? If the... involved in the trespass. We may keep such property we seize for use as evidence. (b) Assess penalties...

  18. 25 CFR 115.613 - Will the BIA record the hearing?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will the BIA record the hearing? 115.613 Section 115.613 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.613 Will the...

  19. 25 CFR 115.613 - Will the BIA record the hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Will the BIA record the hearing? 115.613 Section 115.613 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.613 Will the...

  20. 25 CFR 115.613 - Will the BIA record the hearing?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Will the BIA record the hearing? 115.613 Section 115.613 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.613 Will the...

  1. 25 CFR 115.613 - Will the BIA record the hearing?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Will the BIA record the hearing? 115.613 Section 115.613 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.613 Will the...

  2. 25 CFR 115.613 - Will the BIA record the hearing?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will the BIA record the hearing? 115.613 Section 115.613 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.613 Will the...

  3. 25 CFR 103.5 - What size loan will BIA guarantee or insure?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... insure? BIA can guarantee or insure a loan or combination of loans of up to $500,000 for an individual Indian, or more for an acceptable Indian business entity, Tribe, or tribal enterprise involving two or...

  4. Methane production from formate, acetate and H2/CO2; focusing on kinetics and microbial characterization.

    PubMed

    Pan, Xiaofang; Angelidaki, Irini; Alvarado-Morales, Merlin; Liu, Houguang; Liu, Yuhong; Huang, Xu; Zhu, Gefu

    2016-10-01

    For evaluating the methanogenesis from typical methanogenic precursors (formate, acetate and H2/CO2), CH4 production kinetics were investigated at 37±1°C in batch anaerobic digestion tests and stimulated by modified Gompertz model. The results showed that maximum methanation rate from formate, acetate and H2/CO2 were 19.58±0.49, 42.65±1.17 and 314.64±3.58NmL/gVS/d in digested manure system and 6.53±0.31, 132.04±3.96 and 640.16±19.92NmL/gVS/d in sewage sludge system during second generation incubation. Meanwhile the model could not fit well in granular sludge system, while the rate of formate methanation was faster than from H2/CO2 and acetate. Considering both the kinetic results and microbial assay we could conclude that H2/CO2 methanation was the fastest methanogenic step in digested manure and sewage sludge system with Methanomicrobiales as dominant methanogens, while granular sludge with Methanobacteriales as dominant methanogens contributed to the fastest formate methanation. Copyright © 2016. Published by Elsevier Ltd.

  5. Sphingolipid biosynthesis upregulation by TOR Complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress

    PubMed Central

    Guerreiro, Joana F.; Muir, Alexander; Ramachandran, Subramaniam; Thorner, Jeremy; Sá-Correia, Isabel

    2016-01-01

    Acetic acid-induced inhibition of yeast growth and metabolism limits the productivity of industrial fermentation processes, especially when lignocellulosic hydrolysates are used as feedstock in industrial biotechnology. Tolerance to acetic acid of food spoilage yeasts is also a problem in the preservation of acidic foods and beverages. Thus, understanding the molecular mechanisms underlying adaptation and tolerance to acetic acid stress is increasingly important in industrial biotechnology and the food industry. Prior genetic screens for S. cerevisiae mutants with increased sensitivity to acetic acid identified loss-of-function mutations in the YPK1 gene, which encodes a protein kinase activated by the Target of Rapamycin (TOR) Complex 2 (TORC2). We show here by several independent criteria that TORC2-Ypk1 signaling is stimulated in response to acetic acid stress. Moreover, we demonstrate that TORC2-mediated Ypk1 phosphorylation and activation is necessary for acetic acid tolerance, and occurs independently of Hrk1, a protein kinase previously implicated in the cellular response to acetic acid. In addition, we show that TORC2-Ypk1-mediated activation of L-serine: palmitoyl-CoA acyltransferase, the enzyme complex that catalyzes the first committed step of sphingolipid biosynthesis, is required for acetic acid tolerance. Furthermore, analysis of the sphingolipid pathway using inhibitors and mutants indicates that it is production of certain complex sphingolipids that contributes to conferring acetic acid tolerance. Consistent with that conclusion, promoting sphingolipid synthesis by adding exogenous long-chain base precursor phytosphingosine to the growth medium enhanced acetic acid tolerance. Thus, appropriate modulation of the TORC2-Ypk1-sphingolipid axis in industrial yeast strains may have utility in improving fermentations of acetic acid-containing feedstocks. PMID:27671892

  6. Spectrophotometric determination of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid in pure form and in pharmaceuticals

    NASA Astrophysics Data System (ADS)

    Bazel, Yaroslav; Hunka, Iryna; Kormosh, Zholt; Andruch, Vasil

    2009-12-01

    A new sensitive and selective spectrophotometric method has been developed for the determination of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid in pharmaceuticals in the presence of nicotinic acid. The method is based on the reaction of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid with 1,3,3-trimethyl-5-phenyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indol-2-ylidene)-propenyl]-3 H-indolium chloride (PIC) followed by the extraction of the formed ion associate into toluene and spectrophotometric detection at 581 nm. Appropriate experimental conditions were found to be pH 7.8-9.8 and 3.6 × 10 -4 mol L -1 of PIC. The molar absorptivity is 5.0 × 10 -4 L mol -1 cm -1. The absorbance obeys Beer's law in the range 0.61-12.60 μg mL -1 of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid, and the detection limit calculated from a blank test was 0.20 μg mL -1.

  7. 25 CFR 900.98 - Who takes title to excess BIA or IHS property donated to an Indian tribe or tribal organization?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... an Indian tribe or tribal organization? 900.98 Section 900.98 Indians BUREAU OF INDIAN AFFAIRS... UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Property Donation Procedures Bia and... or tribal organization? The Indian tribe or tribal organization takes title to donated excess BIA or...

  8. 25 CFR 900.98 - Who takes title to excess BIA or IHS property donated to an Indian tribe or tribal organization?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... an Indian tribe or tribal organization? 900.98 Section 900.98 Indians BUREAU OF INDIAN AFFAIRS... UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Property Donation Procedures Bia and... or tribal organization? The Indian tribe or tribal organization takes title to donated excess BIA or...

  9. 25 CFR 900.98 - Who takes title to excess BIA or IHS property donated to an Indian tribe or tribal organization?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... an Indian tribe or tribal organization? 900.98 Section 900.98 Indians BUREAU OF INDIAN AFFAIRS... UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Property Donation Procedures Bia and... or tribal organization? The Indian tribe or tribal organization takes title to donated excess BIA or...

  10. 25 CFR 900.98 - Who takes title to excess BIA or IHS property donated to an Indian tribe or tribal organization?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... an Indian tribe or tribal organization? 900.98 Section 900.98 Indians BUREAU OF INDIAN AFFAIRS... UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Property Donation Procedures Bia and... or tribal organization? The Indian tribe or tribal organization takes title to donated excess BIA or...

  11. Ozone decomposition in aqueous acetate solutions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sehested, K.; Holcman, J.; Bjergbakke, E.

    1987-01-01

    The acetate radical ion reacts with ozone with a rate constant of k = (1.5 +/- 0.5) x 10Z dmT mol s . The products from this reaction are CO2, HCHO, and O2 . By subsequent reaction of the peroxy radical with ozone the acetate radical ion is regenerated through the OH radical. A chain decomposition of ozone takes place. It terminates when the acetate radical ion reacts with oxygen forming the unreactive peroxy acetate radical. The chain is rather short as oxygen is developed, as a result of the ozone consumption. The inhibiting effect of acetate on the ozonemore » decay is rationalized by OH scavenging by acetate and successive reaction of the acetate radical ion with oxygen. Some products from the bimolecular disappearance of the peroxy acetate radicals, however, react further with ozone, reducing the effectiveness of the stabilization.« less

  12. BIA AND DOD SCHOOLS: Student Achievement and Other Characteristics Often Differ from Public Schools

    DTIC Science & Technology

    2001-09-01

    access GAO reports on the Internet, send an e - mail message with “info” in the body to: Info@www.gao.gov or visit GAO’s World Wide Web home page at...may have more than one school. A F R I C A E U R O P E A T L A N T I C O C E A N Page 8 GAO-01-934 BIA and DOD Schools Figure 3: Locations of DOD...A S I A P A C I F I C O C E A N Page 9 GAO-01-934 BIA and DOD Schools Figure 4: Locations of DOD Domestic and Cuba Schools in School Year 1999–2000

  13. 25 CFR 162.108 - What are BIA's responsibilities in administering and enforcing leases?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AND WATER LEASES AND PERMITS General Provisions § 162.108 What are BIA's responsibilities in... obligations that run directly to them, and in the exercise of any negotiated remedies that apply in addition...

  14. 25 CFR 162.108 - What are BIA's responsibilities in administering and enforcing leases?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND WATER LEASES AND PERMITS General Provisions § 162.108 What are BIA's responsibilities in... obligations that run directly to them, and in the exercise of any negotiated remedies that apply in addition...

  15. 25 CFR 162.108 - What are BIA's responsibilities in administering and enforcing leases?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AND WATER LEASES AND PERMITS General Provisions § 162.108 What are BIA's responsibilities in... obligations that run directly to them, and in the exercise of any negotiated remedies that apply in addition...

  16. Comparison of body composition methods during weight loss in obese women using herbal formula.

    PubMed

    Kim, Ho-Jun; Gallagher, Dympna; Song, Mi-Yeon

    2005-01-01

    Bioelectrical impedance analysis (BIA), a device that analyzes the current conduction differences between the fat and water components is widely used for reasons that include convenience of use, non-invasiveness, safety, and low cost. Dual energy X-ray absorptiometry (DXA) allows for the assessment of total body and regional lean and fat tissues and bone mineral content (BMC). The objective of this study was to compare body composition assessments by BIA and DXA before and after a 6-week herbal diet intervention program in 50 pre-menopausal women [mean +/- SD: age 30.58 +/- 6.15, body mass index (BMI) 31.72 +/- 3.78]. Waist-to-hip ratio (WHR) was measured by BIA and anthropometry. Lean body mass (LBM), body fat (BF), BMC and percent body fat (%BF) were measured by BIA and DXA. Highly significant correlations were observed between BIA and DXA measurements for LBM, BF, BMC and %BF (r = 0.73, 0.93, 0.53, 0.79, respectively) before the intervention. Differences between BIA and DXA measurements were observed in LBM, BF, %BF and BMC before intervention (p < 0.01) where WHR by BIA was significantly higher compared to anthropometry before (p < 0.01) and after the intervention (p < 0.01). BIA underestimated LBM by 1.85 kg and overestimated BF by 2.54 kg compared to DXA before the intervention. Although BIA and DXA showed highly significant correlations for LBM, BF, BMC and %BF before the intervention, they did not produce statistically comparable results in pre-menopausal Korean women and therefore should not be used interchangeably when measuring body composition.

  17. 25 CFR 161.610 - What will BIA do if livestock is not removed when a permit expires or is cancelled?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What will BIA do if livestock is not removed when a permit expires or is cancelled? 161.610 Section 161.610 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... will BIA do if livestock is not removed when a permit expires or is cancelled? If the livestock is not...

  18. 4-Nitro­benzyl 2-bromo­acetate

    PubMed Central

    Zhu, Kai; Liu, Hui; Wang, Yan-Hua; Han, Ping-Fang; Wei, Ping

    2009-01-01

    In the mol­ecule of the title compound, C9H8BrNO4, the acetate group is close to planar [maximum deviation = 0.042 (3) Å] and is oriented at a dihedral angle of 73.24 (3)° with respect to the aromatic ring. In the crystal structure, inter­molecular C—H⋯O inter­actions link the mol­ecules into a three-dimensional network, forming R 2 2(10) ring motifs. PMID:21582813

  19. 25 CFR 171.575 - Can BIA charge me a special assessment?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can BIA charge me a special assessment? 171.575 Section 171.575 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... me a special assessment? Yes. We will make every reasonable effort to avoid charging special...

  20. 25 CFR 171.575 - Can BIA charge me a special assessment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can BIA charge me a special assessment? 171.575 Section 171.575 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... me a special assessment? Yes. We will make every reasonable effort to avoid charging special...

  1. 25 CFR 171.575 - Can BIA charge me a special assessment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Can BIA charge me a special assessment? 171.575 Section 171.575 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... me a special assessment? Yes. We will make every reasonable effort to avoid charging special...

  2. 25 CFR 171.575 - Can BIA charge me a special assessment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Can BIA charge me a special assessment? 171.575 Section 171.575 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION... me a special assessment? Yes. We will make every reasonable effort to avoid charging special...

  3. Acetate transport and utilization in the rat brain.

    PubMed

    Deelchand, Dinesh K; Shestov, Alexander A; Koski, Dee M; Uğurbil, Kâmil; Henry, Pierre-Gilles

    2009-05-01

    Acetate, a glial-specific substrate, is an attractive alternative to glucose for the study of neuronal-glial interactions. The present study investigates the kinetics of acetate uptake and utilization in the rat brain in vivo during infusion of [2-13C]acetate using NMR spectroscopy. When plasma acetate concentration was increased, the rate of brain acetate utilization (CMR(ace)) increased progressively and reached close to saturation for plasma acetate concentration > 2-3 mM, whereas brain acetate concentration continued to increase. The Michaelis-Menten constant for brain acetate utilization (K(M)(util) = 0.01 +/- 0.14 mM) was much smaller than for acetate transport through the blood-brain barrier (BBB) (K(M)(t) = 4.18 +/- 0.83 mM). The maximum transport capacity of acetate through the BBB (V(max)(t) = 0.96 +/- 0.18 micromol/g/min) was nearly twofold higher than the maximum rate of brain acetate utilization (V(max)(util) = 0.50 +/- 0.08 micromol/g/min). We conclude that, under our experimental conditions, brain acetate utilization is saturated when plasma acetate concentrations increase above 2-3 mM. At such high plasma acetate concentration, the rate-limiting step for glial acetate metabolism is not the BBB, but occurs after entry of acetate into the brain.

  4. [Effect of acetic acid, furfural and 5-hydroxymethylfurfural on production of 2,3-butanediol by Klebsiella oxytoca].

    PubMed

    Wu, Jing; Cheng, Keke; Li, Wenying; Feng, Jie; Zhang, Jian'an

    2013-03-01

    To get the tolerability and consumption of Klebsiella oxytoca on major inhibitors in lignocelluloses hydrolysate, we studied the effect of acetic acid, furfural and 5-hydroxymethylfurfural on production of 2,3-butanediol by Klebsiella oxytoca. The metabolites of furfural and 5-hydroxymethylfurfural were measured. The results show that when acetic acid, furfural and 5-hydroxymethylfurfural was individually added, tolerance threshold for Klebsiella oxytoca was 30 g/L, 4 g/L and 5 g/L, respectively. Acetic acid was likely used as substrate to produce 2,3-butanediol. The yield of 2,3-butanediol increased when acetic acid concentration was lower than 30 g/L. In the fermentation, more than 70% 5-hydroxymethylfurfural was converted to 2,5-furandimethanol. All furfural and the rest of 5-hydroxymethylfurfural were metabolized by Klebsiella oxytoca. It showed that in the detoxification process of 2,3-butanediol production using lignocelluloses hydrolysate, furfural should be given priority to remove and a certain concentration of acetic acid is not need to removal.

  5. Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.

    PubMed

    Gonçalves, Daniela; Alves, Gilberto; Fortuna, Ana; Soares-da-Silva, Patrício; Falcão, Amílcar

    2016-03-01

    Opicapone is a novel potent, reversible and purely peripheral third generation catechol-O-methyltransferase inhibitor, currently under clinical trials as an adjunct to levodopa therapy for Parkinson's disease. To support additional nonclinical pharmacokinetic studies, a novel high-performance liquid chromatographic method coupled to a diode array detector (HPLC-DAD) to quantify opicapone and its active metabolite (BIA 9-1079) in rat plasma and tissues (liver and kidney) is herein reported. The analytes were extracted from rat samples through a deproteinization followed by liquid-liquid extraction. Chromatographic separation was achieved in less than 10 min on a reversed-phase C18 column, applying a gradient elution program with 0.05 M monosodium phosphate solution (pH 2.45 ± 0.05) and acetonitrile. Calibration curves were linear (r(2)  ≥ 0.994) within the ranges of 0.04-6.0 µg/mL for both analytes in plasma, 0.04-4.0 µg/mL for opicapone in liver and kidney homogenates, and 0.07-4.0 µg/mL and 0.06-4.0 µg/mL for BIA 9-1079 in liver and kidney homogenates, respectively. The overall intra- and inter-day accuracy ranged from -12.68% to 7.70% and the imprecision values did not exceed 11.95%. This new HPLC-DAD assay was also successfully applied to quantify opicapone and BIA 9-1079 in a preliminary pharmacokinetic study. Copyright © 2015 John Wiley & Sons, Ltd.

  6. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its... notice of its decision to restrict your account, the only information the public notice will include is... 25 Indians 1 2010-04-01 2010-04-01 false What information will the BIA include in its notice of...

  7. Kinetic study of benzyl [1-14C]acetate as a potential probe for astrocytic energy metabolism in the rat brain: Comparison with benzyl [2-14C]acetate.

    PubMed

    Okada, Maki; Yanamoto, Kazuhiko; Kagawa, Tomohiko; Yoshino, Keiko; Hosoi, Rie; Abe, Kohji; Zhang, Ming-Rong; Inoue, Osamu

    2016-02-01

    Brain uptake of [(14)C]acetate has been reported to be a useful marker of astrocytic energy metabolism. In addition to uptake values, the rate of radiolabeled acetate washout from the brain appears to reflect CO2 exhaustion and oxygen consumption in astrocytes. We measured the time-radioactivity curves of benzyl [1-(14)C]acetate ([1-(14)C]BA), a lipophilic probe of [1-(14)C]acetate, and compared it with that of benzyl [2-(14)C]acetate ([2-(14)C]BA) in rat brains. The highest brain uptake was observed immediately after injecting either [1-(14)C]BA or [2-(14)C]BA, and both subsequently disappeared from the brain in a single-exponential manner. Estimated [1-(14)C]BA washout rates in the cerebral cortex and cerebellum were higher than those of [2-(14)C]BA. These results suggested that [1-(14)C]BA could be a useful probe for estimating the astrocytic oxidative metabolism. The [1-(14)C]BA washout rate in the cerebral cortex of immature rats was lower than that of mature rats. An autoradiographic study showed that the washout rates of [1-(14)C]BA from the rat brains of a lithium-pilocarpine-induced status epilepticus model were not significantly different from the values in control rat brains except for the medial septal nucleus. These results implied that the enhancement of amino acid turnover rate rather than astrocytic oxidative metabolism was increased in status epilepticus. © The Author(s) 2015.

  8. Conversion to eslicarbazepine acetate monotherapy

    PubMed Central

    French, Jacqueline; Jacobson, Mercedes P.; Pazdera, Ladislav; Gough, Mallory; Cheng, Hailong; Grinnell, Todd; Blum, David

    2016-01-01

    Objective: To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy. Methods: This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical control threshold (65.3%). Results: Pooled exit rates were as follows: ESL 1,600 mg = 20.6% (95% confidence interval: 15.6%–26.8%); ESL 1,200 mg = 30.8% (23.0%–40.5%). Use of 2 baseline AEDs or rescue medication, US location, epilepsy duration ≥20 years, and higher maximum baseline seizure frequency were associated with higher exit risks. Median percent reductions in standardized seizure frequency between baseline and the 18-week double-blind period were as follows: ESL 1,600 mg = 43.2%; ESL 1,200 mg = 35.7%; baseline carbamazepine use was associated with smaller reductions. Safety profiles were similar between ESL doses. Conclusions: Exit rates for ESL monotherapy (1,600 mg and 1,200 mg once daily) were lower than the historical control threshold, irrespective of baseline AED use and region, with no additional safety concerns identified. Clinical factors and location clearly influence treatment responses in conversion-to-monotherapy trials. Classification of evidence: This pooled analysis provides Class IV evidence that for adults with medically uncontrolled partial-onset seizures, ESL monotherapy is well tolerated and effective. PMID:26911639

  9. Plasma membrane proteins Yro2 and Mrh1 are required for acetic acid tolerance in Saccharomyces cerevisiae.

    PubMed

    Takabatake, Akiko; Kawazoe, Nozomi; Izawa, Shingo

    2015-03-01

    Yro2 and its paralogous protein Mrh1 of Saccharomyces cerevisiae have seven predicted transmembrane domains and predominantly localize to the plasma membrane. Their physiological functions and regulation of gene expression have not yet been elucidated in detail. We herein demonstrated that MRH1 was constitutively expressed, whereas the expression of YRO2 was induced by acetic acid stress and entering the stationary phase. Fluorescence microscopic analysis revealed that Mrh1 and Yro2 were distributed as small foci in the plasma membrane under acetic acid stress conditions. The null mutants of these genes (mrh1∆, yro2∆, and mrh1∆yro2∆) showed delayed growth and a decrease in the productivity of ethanol in the presence of acetic acid, indicating that Yro2 and Mrh1 are involved in tolerance to acetic acid stress.

  10. 25 CFR 170.472 - What construction records must tribes and BIA keep?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What construction records must tribes and BIA keep? 170.472 Section 170.472 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities...

  11. 25 CFR 162.108 - What are BIA's responsibilities in administering and enforcing agricultural leases?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases § 162.108 What are BIA's responsibilities in... enforcement of payment obligations that run directly to them, and in the exercise of any negotiated remedies...

  12. 25 CFR 162.108 - What are BIA's responsibilities in administering and enforcing agricultural leases?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases § 162.108 What are BIA's responsibilities in... enforcement of payment obligations that run directly to them, and in the exercise of any negotiated remedies...

  13. Effect of acetate and nitrate anions on the molecular structure of 3-(hydroxyimino)-2-butanone-2-(1H-benzimidazol-2-yl)hydrazone

    NASA Astrophysics Data System (ADS)

    Kamat, Vinayak; Naik, Krishna; Revankar, Vidyanand K.

    2017-04-01

    A novel Schiff base ligand 3-(hydroxyimino)-2-butanone-2-(1H-benzimidazol-2-yl)hydrazone has been synthesized by the condensation reaction of 2-Hydrazinobenzimidazole with diacetyl monoxime in presence of acetic acid catalyst. The ligand has crystallized as its acetate salt, due to the charge-assisted hydrogen bonding between protonated benzimidazole ring and acetate anion. Efforts to synthesize the zinc(II) complex of the title compound, has resulted in the formation of a nitrate salt of the ligand, instead of coordination complex of zinc(II). Acetate salt has crystallized in monoclinic P 21/n, while the nitrate salt has crystallized in a triclinic crystal system with P -1 space group. Hirshfeld surface analysis is presented for both of the crystal structures. Structures of synthesized molecules are even computationally optimized using DFT. A comparative structural approach between the synthesized molecules and DFT optimized structure of bare ligand without any counterions is analyzed in terms of bond parameters. Hydrogen bonding is explained keeping the anions as the central dogma. Mass fragmentation pattern of the organic molecule and comparative account of IR, 1H and 13C NMR chemical shifts are also presented. Compounds are screened for their antibacterial and antifungal potencies against few pathogenic microorganisms. The organic motif is found be an excellent antifungal agent.

  14. Emission characteristics of carboxylates in PM2.5 from incense burning with the effect of light on acetate

    NASA Astrophysics Data System (ADS)

    Kuo, Su-Ching; Tsai, Ying I.; Sopajaree, Khajornsak

    2016-08-01

    Incense burning produces potentially harmful particulate matter. In this study we investigated the emissions of PM2.5 and gaseous acetic acid from four brands of traditional incense; Liao and Shang Lao Shan (SLS), sold in Taiwan, and Thai Yellow (Thai Y) and Thai Black (Thai B), sold in Thailand. Additionally, photochemical reactions of PM2.5 carboxylates emitted from incense burning were studied via a simulated light experiment. The average PM2.5 mass emission factor of each incense type was inversely correlated with the ash production of that incense. The Thailand incense carboxylate emissions were markedly higher than the Taiwan incense. Acetate accounted for 87.46% of total carboxylate emissions, with acetate emitted from the Thailand incense 1.26 times higher than from the Taiwan incense. Phthalate was detected in the PM2.5, indicating the presence of plasticizer. Concentrations of PM2.5 acetate, formate, pyruvate, glutarate, succinate, fumarate and tartarate were reduced in simulated light (51.5%-97.1% of those under dark), indicating that these seven types of carboxylate are easily photodegradable. In contrast, malonate, maleate, oxalate and phthalate concentrations in light were 1.17-1.84 times higher than in darkness, indicating photochemical reactions contribute to the formation of these species. The formation of the low-molecular weight dicarboxylates oxalate and malonate was most noticeable. Acetic acid, highly irritating to the respiratory system and skin, was present at high levels for all four incense types, as shown by the gaseous acetic acid/PM2.5 acetate ratios of 1.03-3.61. Burning incense indoors can generate high concentrations of PM2.5 acetate that increases the risks of respiratory and contact irritation, particularly when burning the Thailand incense. Moreover, burning incense in poorly ventilated, dimly lit indoor areas (e.g., temples and homes) can markedly increase the risk of irritation because the gaseous acetic acid is not degraded as

  15. Activation volume for phosphorus diffusion in silicon and Si0.93Ge0.07

    NASA Astrophysics Data System (ADS)

    Zhao, Yuechao; Aziz, Michael J.; Zangenberg, Nikolaj R.; Larsen, Arne Nylandsted

    2005-04-01

    The hydrostatic pressure dependence of the diffusivity of P in compressively strained Si0.93Ge0.07 and unalloyed Si has been measured. In both cases the diffusivity is almost independent of pressure, characterized by an activation volume V* of (+0.09±0.11) times the atomic volume Ω for the unalloyed Si, and (+0.01±0.06) Ω for Si0.93Ge0.07. The results are used in conjunction with the reported effect of biaxial strain on diffusion normal to the surface to test the prediction for an interstitialcy-based mechanism of Aziz's phenomenological thermodynamic treatment of diffusion under uniform nonhydrostatic stress states. The prediction agrees well with measured behavior, lending additional credence to the interstitial-based mechanism and supporting the nonhydrostatic thermodynamic treatment.

  16. 25 CFR 103.11 - How does BIA approve lenders for the Program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., or receivership. (c) A change in a lender's name, without any other change specified under paragraph... insurance agreement. The lender should notify BIA of its name change as soon as possible. (d) If a lender's.../or loan insurance agreement suspended as of: (1) The effective date of a change in the lender's...

  17. 25 CFR 103.11 - How does BIA approve lenders for the Program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., or receivership. (c) A change in a lender's name, without any other change specified under paragraph... insurance agreement. The lender should notify BIA of its name change as soon as possible. (d) If a lender's.../or loan insurance agreement suspended as of: (1) The effective date of a change in the lender's...

  18. 25 CFR 103.11 - How does BIA approve lenders for the Program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., or receivership. (c) A change in a lender's name, without any other change specified under paragraph... insurance agreement. The lender should notify BIA of its name change as soon as possible. (d) If a lender's.../or loan insurance agreement suspended as of: (1) The effective date of a change in the lender's...

  19. 25 CFR 103.11 - How does BIA approve lenders for the Program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., or receivership. (c) A change in a lender's name, without any other change specified under paragraph... insurance agreement. The lender should notify BIA of its name change as soon as possible. (d) If a lender's.../or loan insurance agreement suspended as of: (1) The effective date of a change in the lender's...

  20. 25 CFR 162.589 - May BIA investigate compliance with a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false May BIA investigate compliance with a WSR lease? 162.589 Section 162.589 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness, Compliance, and Enforcement § 162.589 May...

  1. 25 CFR 162.589 - May BIA investigate compliance with a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false May BIA investigate compliance with a WSR lease? 162.589 Section 162.589 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness, Compliance, and Enforcement § 162.589 May...

  2. Sugar acetates as CO2-philes: molecular interactions and structure aspects from absorption measurement using quartz crystal microbalance.

    PubMed

    Ma, Shao-Ling; Wu, You-Ting; Hurrey, Michael L; Wallen, Scott L; Grant, Christine S

    2010-03-25

    Sugar acetates, recognized as attractive CO(2)-philic compounds, have potential uses as pharmaceutical excipients, controlled release agents, and surfactants for microemulsion systems in CO(2)-based processes. This study focuses on the quantitative examination of absorption of high pressure CO(2) into these sugar derivatives using quartz crystal microbalance (QCM) as a detector. In addition to the absorption measurement, the QCM is initially found to be able to detect the CO(2)-induced deliquescence of sugar acetates, and the CO(2) pressure at which the deliquescence happens depends on several influencing factors such as the temperature and thickness of the film. The CO(2) absorption in alpha-D-glucose pentaacetate (Ac-alpha-GLU) is revealed to be of an order of magnitude larger in comparison with its anomer Ac-beta-GLU, whereas alpha-D-galactose pentaacetate (Ac-alpha-GAL) absorbs CO(2) less than Ac-alpha-GLU due to the steric-hindrance between the acetyl groups on the anomeric and C4 carbons, implying the significant importance of the molecular structure and configuration of sugar acetates on the absorption. The effects of molecular size and acetyl number of sugar acetates on the CO(2) absorption are evaluated and the results indicate that the conformation and packing of crystalline sugar acetate as well as the accessibility of the acetyls are also vital for the absorption of CO(2). It is additionally found that a CO(2)-induced change in the structure from a crystalline system to an amorphous system results in an order of magnitude increase in CO(2) absorption. Further investigation illustrates the interaction strength between sugar acetates and CO(2) by calculating the thermodynamic parameters such as Henry's law constant, enthalpy and entropy of dissolution from the determined CO(2) absorption. Experiments and calculations demonstrate that sugar acetates exhibit high CO(2) absorption, as at least comparable to ionic liquids. Since the ionic liquids have

  3. 25 CFR 161.707 - When will BIA impound unauthorized livestock or other property?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.707 When will BIA impound... livestock or other property refuses to accept delivery of a written notice of trespass and the unauthorized... after 5 days of providing notice of impoundment if the trespasser failed to correct the trespass. ...

  4. 25 CFR 161.707 - When will BIA impound unauthorized livestock or other property?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.707 When will BIA impound... livestock or other property refuses to accept delivery of a written notice of trespass and the unauthorized... after 5 days of providing notice of impoundment if the trespasser failed to correct the trespass. ...

  5. 25 CFR 161.707 - When will BIA impound unauthorized livestock or other property?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.707 When will BIA impound... livestock or other property refuses to accept delivery of a written notice of trespass and the unauthorized... after 5 days of providing notice of impoundment if the trespasser failed to correct the trespass. ...

  6. 25 CFR 161.707 - When will BIA impound unauthorized livestock or other property?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.707 When will BIA impound... livestock or other property refuses to accept delivery of a written notice of trespass and the unauthorized... after 5 days of providing notice of impoundment if the trespasser failed to correct the trespass. ...

  7. 25 CFR 161.707 - When will BIA impound unauthorized livestock or other property?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Actions § 161.707 When will BIA impound... livestock or other property refuses to accept delivery of a written notice of trespass and the unauthorized... after 5 days of providing notice of impoundment if the trespasser failed to correct the trespass. ...

  8. 25 CFR 171.530 - What information must I provide BIA for billing purposes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What information must I provide BIA for billing purposes? 171.530 Section 171.530 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Financial Matters: Assessments, Billing, and Collections § 171.530 What...

  9. 25 CFR 171.530 - What information must I provide BIA for billing purposes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What information must I provide BIA for billing purposes? 171.530 Section 171.530 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Financial Matters: Assessments, Billing, and Collections § 171.530 What...

  10. Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by High Light with Acetate and Fe2.

    PubMed

    He, Bangxiang; Hou, Lulu; Dong, Manman; Shi, Jiawei; Huang, Xiaoyun; Ding, Yating; Cong, Xiaomei; Zhang, Feng; Zhang, Xuecheng; Zang, Xiaonan

    2018-01-07

    Haematococcus pluvialis is a commercial microalga, that produces abundant levels of astaxanthin under stress conditions. Acetate and Fe 2+ are reported to be important for astaxanthin accumulation in H. pluvialis . In order to study the synergistic effects of high light stress and these two factors, we obtained transcriptomes for four groups: high light irradiation (HL), addition of 25 mM acetate under high light (HA), addition of 20 μM Fe 2+ under high light (HF) and normal green growing cells (HG). Among the total clean reads of the four groups, 156,992 unigenes were found, of which 48.88% were annotated in at least one database (Nr, Nt, Pfam, KOG/COG, SwissProt, KEGG, GO). The statistics for DEGs (differentially expressed genes) showed that there were more than 10 thousand DEGs caused by high light and 1800-1900 DEGs caused by acetate or Fe 2+ . The results of DEG analysis by GO and KEGG enrichments showed that, under the high light condition, the expression of genes related to many pathways had changed, such as the pathway for carotenoid biosynthesis, fatty acid elongation, photosynthesis-antenna proteins, carbon fixation in photosynthetic organisms and so on. Addition of acetate under high light significantly promoted the expression of key genes related to the pathways for carotenoid biosynthesis and fatty acid elongation. Furthermore, acetate could obviously inhibit the expression of genes related to the pathway for photosynthesis-antenna proteins. For addition of Fe 2+ , the genes related to photosynthesis-antenna proteins were promoted significantly and there was no obvious change in the gene expressions related to carotenoid and fatty acid synthesis.

  11. Improved assessment of body cell mass by segmental bioimpedance analysis in malnourished subjects and acromegaly.

    PubMed

    Pirlich, M; Schütz, T; Ockenga, J; Biering, H; Gerl, H; Schmidt, B; Ertl, S; Plauth, M; Lochs, H

    2003-04-01

    Estimation of body cell mass (BCM) has been regarded valuable for the assessment of malnutrition. To investigate the value of segmental bioelectrical impedance analysis (BIA) for BCM estimation in malnourished subjects and acromegaly. Nineteen controls and 63 patients with either reduced (liver cirrhosis without and with ascites, Cushing's disease) or increased BCM (acromegaly) were included. Whole-body and segmental BIA (separately measuring arm, trunk, leg) at 50 kHz was compared with BCM measured by total-body potassium. Multiple regression analysis was used to develop specific equations for BCM in each subgroup. Compared to whole-body BIA equations, the inclusion of arm resistance improved the specific equation in cirrhotic patients without ascites and in Cushing's disease resulting in excellent prediction of BCM (R(2) = 0.93 and 0.92, respectively; both P<0.001). In acromegaly, inclusion of resistance and reactance of the trunk best described BCM (R(2) = 0.94, P<0.001). In controls and in cirrhotic patients with ascites, segmental impedance parameters did not improve BCM prediction (best values obtained by whole-body measurements: R(2)=0.88 and 0.60; P<0.001 and <0.003, respectively). Segmental BIA improves the assessment of BCM in malnourished patients and acromegaly, but not in patients with severe fluid overload. Copyright 2003 Elsevier Science Ltd.

  12. 43 CFR 30.272 - What are BIA's duties on payment by the tribe?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What are BIA's duties on payment by the tribe? 30.272 Section 30.272 Public Lands: Interior Office of the Secretary of the Interior INDIAN... duties on payment by the tribe? On payment by the tribe of the interests purchased, the Superintendent...

  13. 43 CFR 30.272 - What are BIA's duties on payment by the tribe?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What are BIA's duties on payment by the tribe? 30.272 Section 30.272 Public Lands: Interior Office of the Secretary of the Interior INDIAN... duties on payment by the tribe? On payment by the tribe of the interests purchased, the Superintendent...

  14. Vibrational dynamics of acetate in D2O studied by infrared pump-probe spectroscopy.

    PubMed

    Banno, Motohiro; Ohta, Kaoru; Tominaga, Keisuke

    2012-05-14

    Solute-solvent interactions between acetate and D(2)O were investigated by vibrational spectroscopic methods. The vibrational dynamics of the COO asymmetric stretching mode in D(2)O was observed by time-resolved infrared (IR) pump-probe spectroscopy. The pump-probe signal contained both decay and oscillatory components. The time dependence of the decay component could be explained by a double exponential function with time constants of 200 fs and 2.6 ps, which are the same for both the COO asymmetric and symmetric stretching modes. The Fourier spectrum of the oscillatory component contained a band around 80 cm(-1), which suggests that the COO asymmetric stretching mode couples to a low-frequency vibrational mode with a wavenumber of 80 cm(-1). Based on quantum chemistry calculations, we propose that a bridged complex comprising an acetate ion and one D(2)O molecule, in which the two oxygen atoms in the acetate anion form hydrogen bonds with the two deuterium atoms in D(2)O, is the most stable structure. The 80 cm(-1) low-frequency mode was assigned to the asymmetric stretching vibration of the hydrogen bond in the bridged complex. This journal is © the Owner Societies 2012

  15. Air Cushion Equipment Transporter (ACET) Testing. Volume 2.

    DTIC Science & Technology

    1986-10-01

    m: lllllhllllEEE 1.0. 1-2-5 w lw w w w w -- * e %. f~n4% AD-A188 369 AFWAL-TR-86-3088 VOLUME 11 AIR CUSHION EQ~UIPuMNT TRNSPO’jRTERi (ACET) TESTING T.D... E . COLCLOUGH, J Chief Vehicle E eupment Division .. If your address has changed, if you wish to be removed from our mailing list, or if the addressee...and ZIP CodeI 10. SOURCE OF FUNDING NOS. PROGRAM PROJECT TASK WORK UNIT ELEMENT NO. NO NO NO II TITLE (includ. Securito C f e ,,n 62201F 2402 01 34 12

  16. Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial.

    PubMed

    Vexiau, P; Chaspoux, C; Boudou, P; Fiet, J; Jouanique, C; Hardy, N; Reygagne, P

    2002-06-01

    Hormone studies have demonstrated the androgen-dependent character of female androgenetic alopecia, but there have been few controlled studies of therapies for alopecia in women. To compare topical minoxidil 2% and cyproterone acetate in the treatment of female alopecia. Sixty-six women with female-pattern alopecia were randomly assigned for 12 cycles into two groups, 33 received two local applications (2 mL day-1) of topical minoxidil 2% plus combined oral contraceptive and 33 received cyproterone acetate 52 mg day-1 plus ethinyl oestradiol 35 microg for 20 of every 28 days. A mean reduction of 2.4 +/- 6.2 per 0.36 cm2 in hairs of diameter > 40 microm was observed in the cyproterone acetate group (P = 0.05) and a mean increase of 6.5 +/- 9 per 0.36 cm2 in the minoxidil group (P < 0.001). Comparison of the total number of hairs at 12 months and the body mass index (BMI) revealed a borderline positive correlation in the cyproterone acetate group (r = 0.39, P = 0.06) and a negative correlation in the minoxidil group (r = -0.42, P < 0.05). No significant difference was observed in the total number of hairs among cyproterone acetate patients according to the presence or absence of other symptoms of hyperandrogenism, whereas in the minoxidil group, the total number of new hairs was higher in patients with isolated alopecia (Delta = 8.1; P < 0.05). Variations in scalp seborrhoea were significant in both groups, but the result was better (for acne and hirsutism as well) in the cyproterone acetate group than in the minoxidil group (P < 0.001). Minoxidil treatment was more effective in the absence of other signs of hyperandrogenism, hyperseborrhoea, and menstrual cycle modifications when the BMI was low, and when nothing argued in favour of biochemical hyperandrogenism. Cyproterone acetate treatment was more effective when other signs were present and when the BMI was elevated, factors that favoured a diagnosis of biochemical hyperandrogenism.

  17. Ab initio Hartree-Fock investigation of 1- H-pyrrolo[3,2- b]pyridine-3-yl acetic acid

    NASA Astrophysics Data System (ADS)

    Ramek, Michael; Tomić, Sanja

    2001-09-01

    The potential energy surface of 1- H-pyrrolo[3,2- b]pyridine-3-yl acetic acid has been investigated via RIIF/6-31G* calculations. The stationary points and reaction paths for syn orientation of the COOH group were determined and are compared with those of the derivatives of 3-indole acetic acid, which act as plant growth hormones. 1- H-pyrrolo[3,2- b]pyridine-3-yl acetic acid forms a kinetically stable conformer with a strong intramolecular hydrogen bond, in which the COOH group is in anti orientation. The influence of this hydrogen bond on bond lengths and vibration frequencies is described.

  18. Identification of novel potential acetate-oxidizing bacteria in an acetate-fed methanogenic chemostat based on DNA stable isotope probing.

    PubMed

    Wang, Hui-Zhong; Gou, Min; Yi, Yue; Xia, Zi-Yuan; Tang, Yue-Qin

    2018-05-11

    Acetate is a significant intermediate of anaerobic fermentation. There are two pathways for converting acetate to CH 4 and CO 2 : acetoclastic methanogenesis by acetoclastic methanogens, and syntrophic acetate oxidation by acetate-oxidizing bacteria (AOB) and hydrogenotrophic methanogens. Detailed investigations of syntrophic acetate-oxidizing bacteria (SAOB) should contribute to the elucidation of the microbial mechanisms of methanogenesis. In this study, we investigated the major phylogenetic groups of acetate-utilizing bacteria (AUB) in a mesophilic methanogenic chemostat fed with acetate as the sole carbon source by using DNA stable isotope probing (SIP) technology. The results indicated that acetoclastic methanogenesis and acetate oxidization/hydrogenotrophic methanogenesis coexisted in the mesophilic chemostat fed with acetate, operated at a dilution rate of 0.1 d -1 . OTU Ace13(9-17) (KU869530), Ace13(9-4) (KU667241), and Ace13(9-23) (KU667236), assigned to the phyla Firmicutes and Bacteroidetes, were probably potential SAOB in the chemostat, which needs further investigation. Species in the phyla Proteobacteria, Deferribacteres, Acidobacteria, Spirochaetes and Actinobacteria were probably capable of utilizing acetate for their growth. Methanoculleus was likely to be the preferred hydrogenotrophic methanogen for syntrophy with AOB in the chemostat.

  19. Measurement and correlation of the solubility of gossypol acetic acid and gossypol acetic acid of optical activity in different solvents

    NASA Astrophysics Data System (ADS)

    Zhang, B.; Tang, H.; Liu, X. Y.; Zhai, X.; Yao, X. C.

    2018-01-01

    The equilibrium method was used to measure the solubility of gossypol acetic acid and gossypol acetic acid of optical activity in isopropyl alcohol, ethanol, acetic acid and ethyl acetate at temperature from 288.15 to 315.15. The Empirical equation and the Apelblat equation model were adopted to correlate the experimental data. For gossypol acetic acid, the root-mean-square deviations (RMSD) were observed in the range of 0.023-4.979 and 0.0112-0.614 for the Empirical equation and the Apelblat equation, respectively. For gossypol acetic acid of optical activity, the RMSD were observed in the range of 0.021-2.211 and 0.021-2.243 for the Empirical equation and the Apelblat equation, individually. And the maximum relative average deviation was 7.5%. Both equations offered an accurate mathematical expression of the experimental results. The calculated solubility showed a good relationship with the experimental solubility for most of solvents. This study provided valuable datas not only for optimizing the process of purification of gossypol acetic acid of optical activity in industry but also for further theoretical studies.

  20. Isolation and characterization of a thermophilic bacterium which oxidizes acetate in syntrophic association with a methanogen and which grows acetogenically on H/sub 2/-CO/sub 2/

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, M.J.; Zinder, S.H.

    1988-01-01

    The authors previously described a thermophilic (60/sup 0/C), syntrophic, two-membered culture which converted acetate to methane via a two-step mechanism in which acetate was oxidized to H/sub 2/ and CO/sub 2/. While the hydrogenotrophic methanogen Methanobacterium sp. strain THF in the biculture was readily isolated, we were unable to find a substrate that was suitable for isolation of the acetate-oxidizing member of the biculture. In this study, we found that the biculture grew on ethylene glycol, and an acetate-oxidizing, rod-shape bacterium (AOR) was isolated from the biculture by dilution into medium containing ethylene glycol as the growth substrate. When themore » axenic culture of the AOR was recombined with a pure culture of Methanobacterium sp. strain THF, the reconstituted biculture grew on acetate and converted it to CH/sub 4/. The AOR used ethylene glycol, 1,2-propanediol, formate, pyruvate, glycine-betaine, and H/sub 2/-CO/sub 2/ as growth substrates. Acetate was the major fermentation product detected from these substrates, except for 1,2-propanediol, which was converted to 1-propanol and propionate. N,N-Dimethylglycine was also formed from glycine-betaine. Acetate was formed in stoichiometric amounts during growth on H/sub 2/-CO/sub 2/, demonstrating that the AOR is an acetogen. This reaction, which was carried out by the pure culture of the AOR in the presence of high partial pressures of H/sub 2/, was the reverse of the acetate oxidation reaction carried out by the AOR when hydrogen partial pressures were kept low by coculturing it with Methanobacterium sp. strain THF. The DNA base composition of the AOR was 47 mol% guanine plus cytosine, and no cytochromes were detected.« less

  1. 25 CFR 170.805 - What are the local, tribal, and BIA roles in transportation facility maintenance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... transportation facility maintenance? 170.805 Section 170.805 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.805 What are the local... Road Maintenance dollars. ...

  2. Localization of the enzymes involved in the photoevolution of H sub 2 from acetate in Chlamydomonas reinhardtii

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Willeford, K.O.; Gibbs, M.

    1989-07-01

    The localization of a series of enzymes involved in the anaerobic photodissimilation of acetate in Chlamydomonas reinhardtii F-60 adapted to a hydrogen metabolism was determined through the enzymatic analyses of the chloroplastic, cytoplasmic, and mitochondrial fractions obtained with a cellular fractionation procedure that incorporated cell wall removal by treatment with autolysine, digestion of the plasmalemma with the detergent digitonin, and fractionation by differential centrifugation on a Percoll step gradient. The sequence of events leading to the photoevolution of H{sub 2} from acetate includes the conversion of acetate into succinate via the extraplastidic glyoxylate cycle, the oxidation of succinate to fumaratemore » by chloroplastic succinate dehydrogenase, and the oxidation of malate to oxaloacetate in the chloroplast by NAD dependent malate dehydrogenase. The level of potential activity for the enzymes assayed were sufficient to accommodate the observed rate of the photoanaerobic dissimilation of acetate and the photoevolution of H{sub 2}.« less

  3. 25 CFR 161.6 - Are there any other restrictions on information given to BIA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are there any other restrictions on information given to BIA? 161.6 Section 161.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Definitions, Authority, Purpose, and Scope § 161.6 Are there any...

  4. 25 CFR 161.6 - Are there any other restrictions on information given to BIA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Are there any other restrictions on information given to BIA? 161.6 Section 161.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Definitions, Authority, Purpose, and Scope § 161.6 Are there any...

  5. Co-production of furfural and acetic acid from corncob using ZnCl2 through fast pyrolysis in a fluidized bed reactor.

    PubMed

    Oh, Seung-Jin; Jung, Su-Hwa; Kim, Joo-Sik

    2013-09-01

    Corncob was pyrolyzed using ZnCl2 in a pyrolysis plant equipped with a fluidized bed reactor to co-produce furfural and acetic acid. The effects of reaction conditions, the ZnCl2 content and contacting method of ZnCl2 with corncob on the yields of furfural and acetic acid were investigated. The pyrolysis was performed within the temperature range between 310 and 410°C, and the bio-oil yield were 30-60 wt% of the product. The furfural yield increased up to 8.2 wt%. The acetic acid yield was maximized with a value of 13.1 wt%. A lower feed rate in the presence of ZnCl2 was advantageous for the production of acetic acid. The fast pyrolysis of a smaller corncob sample mechanically mixed with 20 wt% of ZnCl2 gave rise to a distinct increase in furfural. A high selectivity for furfural and acetic acid in bio-oil would make the pyrolysis of corncob with ZnCl2 very economically attractive. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. Influence of acute consumption of caffeine vs. placebo over Bia-derived measurements of body composition: a randomized, double-blind, crossover design.

    PubMed

    Williamson, Cassie M; Nickerson, Brett S; Bechke, Emily E; McLester, Cherilyn N; Kliszczewicz, Brian M

    2018-01-01

    Bioelectrical impedance analysis (BIA) is often used to estimate total body water (TBW), intracellular body water (ICW), extracellular body water (ECW), and body fat percentage (BF%). A common restriction for BIA analysis is abstinence from caffeine 12-h prior to testing. However, research has yet to determine whether the consumption of caffeine influences BIA testing results. The purpose of this study was to determine if the consumption of caffeine influences BIA-derived BF% and body water values in habitual caffeine users. Twenty apparently healthy males (26.6 ± 4.1 years) identified as habitual caffeine consumers (≥ one 95 mg serving per day ≥ four days per week) participated in this study. Participants came to the lab on three occasions, the first visit serving as the control (CON) with no supplementation. The remaining two visits were performed in a randomized double-blind, cross-over fashion. Participants consumed 200 mg of dextrose (PLA) or caffeine (CAF) in capsule form. During each visit, seven multi-frequency BIA measurements were conducted before (PRE) and after (15-min, 30-min, 45-min, 60-min, 75-min, 90-min) consumption. Repeated measures ANOVA revealed BF% for CAF was lower than the CON and PLA conditions at PRE and 15-min ( p  < 0.001, p  = 0.004), but not statistically significant for the remaining time points (i.e., 30-, 45-, 60-, 75-, and 90-min). However, the effect size (ES) of the BF% differences were trivial. The CON, PLA, and CAF conditions had higher PRE ICW values than their associated post time points (i.e., 15-, 30-, 45-, 60-, 75-, and 90-min). Similar to BF%, ES of the mean differences for ICW were trivial. No other differences were observed. Caffeine consumption in habitual users produced trivial changes in TBW, ECW, ICW, or BF%. Therefore, the pre-testing guidelines for caffeine consumption may not be necessary in habitual caffeine consumers.

  7. The implementation of high fermentative 2,3-butanediol production from xylose by simultaneous additions of yeast extract, Na2EDTA, and acetic acid.

    PubMed

    Wang, Xiao-Xiong; Hu, Hong-Ying; Liu, De-Hua; Song, Yuan-Quan

    2016-01-25

    The effective use of xylose may significantly enhance the feasibility of using lignocellulosic hydrolysate to produce 2,3-butanediol (2,3-BD). Previous difficulties in 2,3-BD production include that the high-concentration xylose cannot be converted completely and the fermentation rate is slow. This study investigated the effects of yeast extract, ethylenediaminetetraacetic acid disodium salt (Na2EDTA), and acetic acid on 2,3-BD production from xylose. The central composite design approach was used to optimize the concentrations of these components. It was found that simultaneous addition of yeast extract, Na2EDTA, and acetic acid could significantly improve 2,3-BD production. The optimal concentrations of yeast extract, Na2EDTA, and acetic acid were 35.2, 1.2, and 4.5 g/L, respectively. The 2,3-BD concentration in the optimized medium reached 39.7 g/L after 48 hours of shake flask fermentation, the highest value ever reported in such a short period. The xylose utilization ratio and the 2,3-BD concentration increased to 99.0% and 42.7 g/L, respectively, after 48 hours of stirred batch fermentation. Furthermore, the 2,3-BD yield was 0.475 g/g, 95.0% of the theoretical maximum value. As the major components of lignocellulosic hydrolysate are glucose, xylose, and acetic acid, the results of this study indicate the possibility of directly using the hydrolysate to effectively produce 2,3-BD. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Chelating agents related to ethylenediamine bis(2-hydroxyphenyl)acetic acid (EDDHA): synthesis, characterization, and equilibrium studies of the free ligands and their Mg2+, Ca2+, Cu2+, and Fe3+ chelates.

    PubMed

    Yunta, Felipe; García-Marco, Sonia; Lucena, Juan J; Gómez-Gallego, Mar; Alcázar, Roberto; Sierra, Miguel A

    2003-08-25

    Iron chelates such as ethylenediamine-N,N'-bis(2-hydroxyphenyl)acetic acid (EDDHA) and their analogues are the most efficient soil fertilizers to treat iron chlorosis in plants growing in calcareous soils. EDDHA, EDDH4MA (ethylenediamine-N,N'-bis(2-hydroxy-4-methylphenyl)acetic acid), and EDDCHA (ethylenediamine-N,N'-bis(2-hydroxy-5-carboxyphenyl)acetic acid) are allowed by the European directive, but also EDDHSA (ethylenediamine-N,N'-bis(2-hydroxy-5-sulfonylphenyl)acetic acid) and EDDH5MA (ethylenediamine-N,N'-bis(2-hydroxy-5-methylphenyl)acetic acid) are present in several commercial iron chelates. In this study, these chelating agents as well as p,p-EDDHA (ethylenediamine-N,N'-bis(4-hydroxyphenyl)acetic acid) and EDDMtxA (ethylenediamine-N,N'-bis(2-metoxyphenyl)acetic acid) have been obtained following a new synthetic pathway. Their chemical behavior has been studied to predict the effect of the substituents in the benzene ring on their efficacy as iron fertilizers for soils above pH 7. The purity of the chelating agents has been determined using a novel methodology through spectrophotometric titration at 480 nm with Fe(3+) as titrant to evaluate the inorganic impurities. The protonation constants were determined by both spectrophotometric and potentiometric methods, and Ca(2+) and Mg(2+) stability constants were determined from potentiometric titrations. To establish the Fe(3+) and Cu(2+) stability constants, a new spectrophotometric method has been developed, and the results were compared with those reported in the literature for EDDHA and EDDHMA and their meso- and rac-isomers. pM values have been also determined to provide a comparable basis to establish the relative chelating ability of these ligands. The purity obtained for the ligands is higher than 87% in all cases and is comparable with that obtained by (1)H NMR. No significant differences have been found among ligands when their protonation and stability constants were compared. As expected, no Fe(3

  9. Parameters affecting acetate concentrations during in-situ biological hydrogen methanation.

    PubMed

    Agneessens, Laura Mia; Ottosen, Lars Ditlev Mørck; Andersen, Martin; Berg Olesen, Christina; Feilberg, Anders; Kofoed, Michael Vedel Wegener

    2018-06-01

    Surplus electricity may be supplied to anaerobic digesters as H 2 gas to upgrade the CH 4 content of biogas. Acetate accumulation has been observed following H 2 injections, but the parameters determining the degree of acetate accumulation are not well understood. The pathways involved during H 2 consumption and acetate kinetics were evaluated in continuous lab reactors and parallel batch 13 C experiments. Acetate accumulation increased during initial H 2 injections as organic loading rate increased and CO 2 levels decreased below 7%. The share of CH 4 in H 2 and 13 C mass balances increased after repeated H 2 injections, which corresponded with the increase of Methanomicrobiales observed via qPCR. The organic loading rate, the inorganic carbon level and level of methanogen adaption hence determine acetate kinetics during biomethanation of H 2 . The three identified parameters may form the base of a decision tool to assess acetate accumulation during H 2 injections to an anaerobic digester. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Disorder effects in Mn(12)-acetate at 83 K.

    PubMed

    Cornia, Andrea; Fabretti, Antonio Costantino; Sessoli, Roberta; Sorace, Lorenzo; Gatteschi, Dante; Barra, Anne-Laure; Daiguebonne, Carole; Roisnel, Thierry

    2002-07-01

    The structure of hexadeca-mu-acetato-tetraaquadodeca-mu(3)-oxo-dodecamanganese bis(acetic acid) tetrahydrate, [Mn(12)O(12)(CH(3)COO)(16)(H(2)O)(4)] x 2CH(3)COOH x 4H(2)O, known as Mn(12)-acetate, has been determined at 83 (2) K by X-ray diffraction methods. The fourfold (S(4)) molecular symmetry is disrupted by a strong hydrogen-bonding interaction with the disordered acetic acid molecule of solvation, which displaces one of the acetate ligands in the cluster. Up to six Mn(12) isomers are potentially present in the crystal lattice, which differ in the number and arrangement of hydrogen-bonded acetic acid molecules. These results considerably improve the structural information available on this molecular nanomagnet, which was first synthesized and characterized by Lis [Acta Cryst. (1980), B36, 2042-2046].

  11. N-(6-Methylpyridin-2-yl)mesitylenesulfonamide and acetic acid--a salt, a cocrystal or both?

    PubMed

    Pan, Fangfang; Kalf, Irmgard; Englert, Ulli

    2015-08-01

    In the solid obtained from N-(6-methylpyridin-2-yl)mesitylenesulfonamide and acetic acid, the constituents interact via two N-H···O hydrogen bonds. The H atom situated in one of these short contacts is disordered over two positions: one of these positions is formally associated with an adduct of the neutral sulfonamide molecule and the neutral acetic acid molecule, and corresponds to a cocrystal, while the alternative site is associated with salt formation between a protonated sulfonamide molecule and deprotonated acetic acid molecule. Site-occupancy refinements and electron densities from difference Fourier maps suggest a trend with temperature, albeit of limited significance; the cocrystal is more relevant at 100 K, whereas the intensity data collected at room temperature match the description as cocrystal and salt equally well.

  12. Metabolism of triacetin-derived acetate in dogs.

    PubMed

    Bleiberg, B; Beers, T R; Persson, M; Miles, J M

    1993-12-01

    Triacetin is a water-soluble triglyceride that may have a role as a parenteral nutrient. In the present study triacetin was administered intravenously to mongrel dogs (n = 10) 2 wk after surgical placement of blood-sampling catheters in the aorta and in the portal, hepatic, renal, and femoral veins. [1-14C]Acetate was infused to allow quantification of organ uptake of acetate as well as systemic turnover and oxidation. Systemic acetate turnover accounted for approximately 70% of triacetin-derived acetate, assuming complete hydrolysis of the triglyceride. Approximately 80% of systemic acetate uptake was rapidly oxidized. Significant acetate uptake was demonstrated in all tissues (liver, 559 +/- 68; intestine, 342 +/- 23; hindlimb, 89 +/- 7; and kidney, 330 +/- 37 mumol/min). In conclusion, during intravenous administration in dogs, the majority of infused triacetin undergoes intravascular hydrolysis, and the majority of the resulting acetate is oxidized. Thus, energy in the form of short-chain fatty acids can be delivered to a resting gut via intravenous infusion of a short-chain triglyceride.

  13. 25 CFR 1000.210 - When does a non-BIA bureau use a public consultation process related to the negotiation of an AFA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false When does a non-BIA bureau use a public consultation process related to the negotiation of an AFA? 1000.210 Section 1000.210 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN...

  14. 25 CFR 10.11 - How would someone detained or incarcerated, or their representative, get the BIA policies and...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... are used for operations or maintenance programs, the BIA's policies, standards, and procedures will be... physical or mental condition of the person at time of incarceration. In these cases, the Inmate Handbook...

  15. 25 CFR 1000.62 - Who can apply to OSG for grants to plan and negotiate non-BIA programs?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.62 Who can apply to OSG for grants...

  16. 25 CFR 1000.62 - Who can apply to OSG for grants to plan and negotiate non-BIA programs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.62 Who can apply to OSG for grants...

  17. 25 CFR 1000.62 - Who can apply to OSG for grants to plan and negotiate non-BIA programs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.62 Who can apply to OSG for grants...

  18. 25 CFR 1000.62 - Who can apply to OSG for grants to plan and negotiate non-BIA programs?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.62 Who can apply to OSG for grants...

  19. 25 CFR 1000.62 - Who can apply to OSG for grants to plan and negotiate non-BIA programs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.62 Who can apply to OSG for grants...

  20. Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy.

    PubMed

    Palle, Stine S; Møllehave, Line T; Taheri-Kadkhoda, Zahra; Johansen, Susanne; Larsen, Lisbeth; Hansen, Janne W; Jensen, Nikolaj K G; Elingaard, Anette O; Møller, Alice H; Larsen, Karen; Andersen, Jens R

    2016-12-01

    Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments. To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy. In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight. 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were available for follow-up. BIA overestimated FFM kg for all 31 measurements with mean (SD) 18.0 kg (6.0) compared to the MRI. ST overestimated FFM kg with mean 12.4 kg (6.2) and L2000 underestimated SM kg in 18 measurements and overestimated in 13 with a total mean of -4.3 kg (6.8). BIA and ST were the best alternatives to MRI as they showed constant and thereby correctable errors. The equation, L2000, carried the smallest average measurement error but it was non-constant. Copyright © 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

  1. The acetate switch.

    PubMed

    Wolfe, Alan J

    2005-03-01

    To succeed, many cells must alternate between life-styles that permit rapid growth in the presence of abundant nutrients and ones that enhance survival in the absence of those nutrients. One such change in life-style, the "acetate switch," occurs as cells deplete their environment of acetate-producing carbon sources and begin to rely on their ability to scavenge for acetate. This review explains why, when, and how cells excrete or dissimilate acetate. The central components of the "switch" (phosphotransacetylase [PTA], acetate kinase [ACK], and AMP-forming acetyl coenzyme A synthetase [AMP-ACS]) and the behavior of cells that lack these components are introduced. Acetyl phosphate (acetyl approximately P), the high-energy intermediate of acetate dissimilation, is discussed, and conditions that influence its intracellular concentration are described. Evidence is provided that acetyl approximately P influences cellular processes from organelle biogenesis to cell cycle regulation and from biofilm development to pathogenesis. The merits of each mechanism proposed to explain the interaction of acetyl approximately P with two-component signal transduction pathways are addressed. A short list of enzymes that generate acetyl approximately P by PTA-ACKA-independent mechanisms is introduced and discussed briefly. Attention is then directed to the mechanisms used by cells to "flip the switch," the induction and activation of the acetate-scavenging AMP-ACS. First, evidence is presented that nucleoid proteins orchestrate a progression of distinct nucleoprotein complexes to ensure proper transcription of its gene. Next, the way in which cells regulate AMP-ACS activity through reversible acetylation is described. Finally, the "acetate switch" as it exists in selected eubacteria, archaea, and eukaryotes, including humans, is described.

  2. 21 CFR 73.2396 - Lead acetate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... acetate is the trihydrate of lead (2+) salt of acetic acid. The color additive has the chemical formula Pb... cosmetics intended for coloring hair on the scalp only, subject to the following restrictions: (1) The... mustaches, eyelashes, eyebrows, or hair on parts of the body other than the scalp. (d) Labeling requirements...

  3. 21 CFR 73.2396 - Lead acetate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... acetate is the trihydrate of lead (2+) salt of acetic acid. The color additive has the chemical formula Pb... cosmetics intended for coloring hair on the scalp only, subject to the following restrictions: (1) The... mustaches, eyelashes, eyebrows, or hair on parts of the body other than the scalp. (d) Labeling requirements...

  4. 21 CFR 73.2396 - Lead acetate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... acetate is the trihydrate of lead (2+) salt of acetic acid. The color additive has the chemical formula Pb... cosmetics intended for coloring hair on the scalp only, subject to the following restrictions: (1) The... mustaches, eyelashes, eyebrows, or hair on parts of the body other than the scalp. (d) Labeling requirements...

  5. 21 CFR 73.2396 - Lead acetate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... acetate is the trihydrate of lead (2+) salt of acetic acid. The color additive has the chemical formula Pb... cosmetics intended for coloring hair on the scalp only, subject to the following restrictions: (1) The... mustaches, eyelashes, eyebrows, or hair on parts of the body other than the scalp. (d) Labeling requirements...

  6. 21 CFR 73.2396 - Lead acetate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... acetate is the trihydrate of lead (2+) salt of acetic acid. The color additive has the chemical formula Pb... cosmetics intended for coloring hair on the scalp only, subject to the following restrictions: (1) The... mustaches, eyelashes, eyebrows, or hair on parts of the body other than the scalp. (d) Labeling requirements...

  7. Occurrence of microbial acetate-oxidation in ~2 km-deep coal-bearing sediments off the Shimokita Peninsula, Japan (IODP Expedition 337)

    NASA Astrophysics Data System (ADS)

    Ijiri, A.; Inagaki, F.

    2015-12-01

    During the Integrated Ocean Drilling Program (IODP) Expedition 337 in 2012, the riser-drilling vessel Chikyu extended the previous world depth record of scientific ocean drilling and made one of the deepest scientific borehole down to 2466 m below the seafloor (mbsf) at Site C0020 Hole A off the Shimokita Peninsula, Japan. The sedimentary sequence consists of 17 lignite layers below 1.5 km bellow the seafloor. Microbiological and geochemical data consistently showed evidence for the existence of microbial communities associated with lignite coal beds in the coal-bearing sediments (Inagaki and Hinrichs et al., Science, 2015). Since lignite coals produce substantial dissolved organic compounds during the burial alternation process, volatile fatty acids may play important roles for microbial life and its activity in the deep sedimentary environment. To address this hypothesis, we measured methanogenic and acetate-oxidation activities by radiotracer incubation experiments using 14C-labelled substrate ([2-14C]-acetate) immediately after core recovery. Activity of aceticlastic methanogenesis was observed in the sediment above the coal-baring layers (>1990 mbsf), ranging from 0.2 to 1.2 pmol cm-3 d-1. The highest activity was observed in a coal-bed horizon at 1990 mbsf. However, aceticlastic methanogenesis was below the detection limit in sediment samples below the 2 km-coal layers. Activity of acetate oxidation to CO2 was measured by 14CO2 production rate from [2-14C]-acetate. Interestingly, the acetate-oxidation activity was observed in sediments above the coal beds, which values were generally higher than those of methanogenesis with the maximum value of 33 pmol cm-3 d-1 at 1800 mbsf. The rates gradually decreased with increasing depth from 1800 mbsf and reached below the detection limit (i.e., 0.05 pmol cm-3 d-1) in 2 km-deep coal-bed samples. The occurrence of relatively high acetate oxidation at ~1800 mbsf above the coal formation suggests that microbes respire

  8. Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.

    PubMed

    Mathew, Raji; Arun, Peethambaran; Madhavarao, Chikkathur N; Moffett, John R; Namboodiri, M A Aryan

    2005-10-01

    Canavan disease (CD) is a fatal genetic neurodegenerative disorder caused by mutations in the gene for aspartoacylase, an enzyme that hydrolyzes N-acetylaspartate (NAA) into L-aspartate and acetate. Because aspartoacylase is localized in oligodendrocytes, and NAA-derived acetate is incorporated into myelin lipids, we hypothesize that an acetate deficiency in oligodendrocytes is responsible for the pathology in CD, and we propose acetate supplementation as a possible therapy. In our preclinical efforts toward this goal, we studied the effectiveness of orally administered glyceryl triacetate (GTA) and calcium acetate for increasing acetate levels in the murine brain. The concentrations of brain acetate and NAA were determined simultaneously after intragastric administration of GTA. We found that the acetate levels in brain were increased in a dose- and time-dependent manner, with a 17-fold increase observed at 1 to 2 h in 20- to 21-day-old mice at a dose of 5.8 g/kg GTA. NAA levels in the brain were not significantly increased under these conditions. Studies using mice at varying stages of development showed that the dose of GTA required to maintain similarly elevated acetate levels in the brain increased with age. Also, GTA was significantly more effective as an acetate source than calcium acetate. Chronic administration of GTA up to 25 days of age did not result in any overt pathology in the mice. Based on these results and the current Food and Drug Administration-approved use of GTA as a food additive, we propose that it is a potential candidate for use in acetate supplementation therapy for CD.

  9. (Na{sub x}k{sub 1−x}){sub 2}Ta{sub 4}O{sub 11}(x≈0.93) piezoelectric phase from the transformation of Ta{sub 2}O{sub 5} thin films of monoclinic structure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Le Gallic, M., E-mail: Marie.Le-Gallic@grenoble-inp.fr; Roussel, H.

    2013-04-15

    A phase of trigonal structure has been reported in previous articles to be piezoelectric with a very high longitudinal d{sub 33} coefficient of several thousand pm/V (J. Solid State Chem. 184 (2011) 2023, 2033). It was observed in Ta{sub 2}O{sub 5} thin films and assumed to be the result of a reversible monoclinic–trigonal phase transition. However, new investigations are reported because the cell parameters of this phase are actually very close to those of the natrotantite mineral Na{sub 2}Ta{sub 4}O{sub 11}. From analyses by X-ray energy dispersive spectroscopy (XEDS), the chemical composition of this trigonal phase corresponds to (Na{sub x}K{submore » 1−x}){sub 2}Ta{sub 4}O{sub 11} with x≈0.93. The origin of sodium, potassium, iron and oxygen atoms is found to be due to a pollution coming from alumina crucibles used for thermal treatments. Knowing both atomic structures Ta{sub 2}O{sub 5} and Na{sub 2}Ta{sub 4}O{sub 11} and their structural relationships, observed by high resolution transmission electron microscopy (HRTEM), the mechanism of the reaction of transformation is re-examined and discussed. This mechanism implies that Ta{sup 5+} vacancies likely exist in monoclinic structures of tantalum oxide and that electrical neutrality could be due to incorporated proton H{sup +} instead of O{sup 2−} vacancies or Ta{sup 5+} interstitials. - Graphical abstract: (a, b) TEM images of interfaces between Ta{sub 2}O{sub 5} monoclinic and (Na{sub 0.93}K{sub 0.07}){sub 2}Ta{sub 4}O{sub 11} trigonal phases where it appears that the ratio of periods for the transformation monoclinic-to-trigonal is 3/2 (c, d) corresponding schema of the reaction of transformation, (a, c) viewed along the zone axes [010]{sub o}∥[1{sup ¯}21{sup ¯}]{sub R} and (b, d) along the zone axes [100]{sub o}∥[101{sup ¯}]{sub R}. Highlights: ► The formation of a piezoelectric phase in Ta{sub 2}O{sub 5} thin films, reported in previous articles, is re-examined. ► Its composition is

  10. 25 CFR 115.615 - How long after the hearing will BIA make its final decision?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How long after the hearing will BIA make its final decision? 115.615 Section 115.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM...

  11. 25 CFR 115.615 - How long after the hearing will BIA make its final decision?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How long after the hearing will BIA make its final decision? 115.615 Section 115.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM...

  12. 25 CFR 115.615 - How long after the hearing will BIA make its final decision?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How long after the hearing will BIA make its final decision? 115.615 Section 115.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM...

  13. 25 CFR 115.615 - How long after the hearing will BIA make its final decision?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How long after the hearing will BIA make its final decision? 115.615 Section 115.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM...

  14. 25 CFR 115.615 - How long after the hearing will BIA make its final decision?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How long after the hearing will BIA make its final decision? 115.615 Section 115.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM...

  15. Acetate Utilization and Butyryl Coenzyme A (CoA):Acetate-CoA Transferase in Butyrate-Producing Bacteria from the Human Large Intestine

    PubMed Central

    Duncan, Sylvia H.; Barcenilla, Adela; Stewart, Colin S.; Pryde, Susan E.; Flint, Harry J.

    2002-01-01

    Seven strains of Roseburia sp., Faecalibacterium prausnitzii, and Coprococcus sp. from the human gut that produce high levels of butyric acid in vitro were studied with respect to key butyrate pathway enzymes and fermentation patterns. Strains of Roseburia sp. and F. prausnitzii possessed butyryl coenzyme A (CoA):acetate-CoA transferase and acetate kinase activities, but butyrate kinase activity was not detectable either in growing or in stationary-phase cultures. Although unable to use acetate as a sole source of energy, these strains showed net utilization of acetate during growth on glucose. In contrast, Coprococcus sp. strain L2-50 is a net producer of acetate and possessed detectable butyrate kinase, acetate kinase, and butyryl-CoA:acetate-CoA transferase activities. These results demonstrate that different functionally distinct groups of butyrate-producing bacteria are present in the human large intestine. PMID:12324374

  16. Aerobic Oxidation of 5-(Hydroxymethyl)furfural Cyclic Acetal Enables Selective Furan-2,5-dicarboxylic Acid Formation with CeO2 -Supported Gold Catalyst.

    PubMed

    Kim, Minjune; Su, Yaqiong; Fukuoka, Atsushi; Hensen, Emiel J M; Nakajima, Kiyotaka

    2018-05-14

    The utilization of 5-(hydroxymethyl)furfural (HMF) for the large-scale production of essential chemicals has been largely limited by the formation of solid humin as a byproduct, which prevents the operation of stepwise batch-type and continuous flow-type processes. The reaction of HMF with 1,3-propanediol produces an HMF acetal derivative that exhibits excellent thermal stability. Aerobic oxidation of the HMF acetal with a CeO 2 -supported Au catalyst and Na 2 CO 3 in water gives a 90-95 % yield of furan 2,5-dicarboxylic acid, an increasingly important commodity chemical for the biorenewables industry, from concentrated solutions (10-20 wt %) without humin formation. The six-membered acetal ring suppresses thermal decomposition and self-polymerization of HMF in concentrated solutions. Kinetic studies supported by DFT calculations identify two crucial steps in the reaction mechanism, that is, the partial hydrolysis of the acetal into 5-formyl-2-furan carboxylic acid involving OH - and Lewis acid sites on CeO 2 , and subsequent oxidative dehydrogenation of the in situ generated hemiacetal involving Au nanoparticles. These results represent a significant advance over the current state of the art, overcoming an inherent limitation of the oxidation of HMF to an important monomer for biopolymer production. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase

    PubMed Central

    Van Hellemond, Jaap J.; Opperdoes, Fred R.; Tielens, Aloysius G. M.

    1998-01-01

    Hydrogenosome-containing anaerobic protists, such as the trichomonads, produce large amounts of acetate by an acetate:succinate CoA transferase (ASCT)/succinyl CoA synthetase cycle. The notion that mitochondria and hydrogenosomes may have originated from the same α-proteobacterial endosymbiont has led us to look for the presence of a similar metabolic pathway in trypanosomatids because these are the earliest-branching mitochondriate eukaryotes and because they also are known to produce acetate. The mechanism of acetate production in these organisms, however, has remained unknown. Four different members of the trypanosomatid family: promastigotes of Leishmania mexicana mexicana, L. infantum and Phytomonas sp., and procyclics of Trypanosoma brucei were analyzed as well as the parasitic helminth Fasciola hepatica. They all use a mitochondrial ASCT for the production of acetate from acetyl CoA. The succinyl CoA that is produced during acetate formation by ASCT is recycled presumably to succinate by a mitochondrial succinyl CoA synthetase, concomitantly producing ATP from ADP. The ASCT of L. mexicana mexicana promastigotes was further characterized after partial purification of the enzyme. It has a high affinity for acetyl CoA (Km 0.26 mM) and a low affinity for succinate (Km 6.9 mM), which shows that significant acetate production can occur only when high mitochondrial succinate concentrations prevail. This study identifies a metabolic pathway common to mitochondria and hydrogenosomes, which strongly supports a common origin for these two organelles. PMID:9501211

  18. Activation of methyl acetate on Pd(111)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xu, Lijun; Xu, Ye

    2010-01-01

    The absorption and activation of methyl acetate (CH{sub 3}COOCH{sub 3}), one of the simplest carboxylic esters, on Pd(111) have been studied using self-consistent periodic density functional theory calculations. Methyl acetate adsorbs weakly through the carbonyl oxygen. Its activation occurs via dehydrogenation, instead of direct C-O bond dissociation, on clean Pd(111): It is much more difficult to dissociate the C--O bonds ({epsilon}{sub a} ? 2.0 eV for the carbonyl and acetate-methyl bonds; {epsilon}{sub a} = 1.0 eV for the acetyl-methoxy bond) than to dissociate the C-H bonds to produce enolate (CH{sub 2}COOCH{sub 3}; {epsilon}{sub a} = 0.74 eV) or methylene acetatemore » (CH{sub 3}COOCH{sub 2}; {epsilon}{sub a} = 0.82 eV). The barriers for C-H and C-O bond dissociation are directly calculated for enolate and methylene acetate, and estimated for further dehydrogenated derivatives (CH{sub 3}COOCH, CH{sub 2}COOCH{sub 2}, and CHCOOCH{sub 3}) based on the Bronsted-Evans-Polanyi linear energy relations formed by the calculated steps. The enolate pathway leads to successive dehydrogenation to CCOOCH{sub 3}, whereas methylene acetate readily dissociates to yield acetyl. The selectivity for dissociating the acyl-alkoxy C-O bond, which is desired for alcohol formation, is therefore fundamentally limited by the facility of dehydrogenation under vacuum/low-pressure conditions on Pd(111).« less

  19. Impact of Transfer of Schools and Pupils from BIA to Public Schools. A Position Paper.

    ERIC Educational Resources Information Center

    Wight, Edgar L.

    The transfer of schools operated by the Bureau of Indian Affairs (BIA) to public school systems has been occurring for more than 100 years. When these schools are transferred to the public school systems, a financial impact on school operations, school construction, and the instructional program is felt by the public schools. Because of the…

  20. 25 CFR 162.591 - What will BIA do about a violation of a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What will BIA do about a violation of a WSR lease? 162.591 Section 162.591 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness, Compliance, and Enforcement § 162...

  1. 25 CFR 162.591 - What will BIA do about a violation of a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What will BIA do about a violation of a WSR lease? 162.591 Section 162.591 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness, Compliance, and Enforcement § 162...

  2. BIA Chief Area Office Education Officers' Quarterly Conference (Las Vegas, Nevada, October 14-16, 1975). Research and Evaluation Report Series No. 34.02.

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Albuquerque, NM.

    Highlights from the quarterly conference of the Bureau of Indian Affairs' (BIA) Chief Area Education Officers meeting (held in Las Vegas, Nevada on October 14-16, 1975) are presented in this conference report. Included in the report are: (1) a participant list; (2) reports from each of the 10 Area Offices; (3) the conference agenda; (4) a speech…

  3. 25 CFR 161.714 - How will BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... enforcement of the trespass? 161.714 Section 161.714 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.714 How will BIA determine the costs associated with enforcement of the trespass? Costs of...

  4. 25 CFR 161.714 - How will BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... enforcement of the trespass? 161.714 Section 161.714 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.714 How will BIA determine the costs associated with enforcement of the trespass? Costs of...

  5. 25 CFR 161.714 - How will BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... enforcement of the trespass? 161.714 Section 161.714 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.714 How will BIA determine the costs associated with enforcement of the trespass? Costs of...

  6. 25 CFR 161.714 - How will BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... enforcement of the trespass? 161.714 Section 161.714 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.714 How will BIA determine the costs associated with enforcement of the trespass? Costs of...

  7. 25 CFR 161.714 - How will BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... enforcement of the trespass? 161.714 Section 161.714 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.714 How will BIA determine the costs associated with enforcement of the trespass? Costs of...

  8. 25 CFR 170.232 - How does a tribe appeal a disapproval from the BIA Regional Director?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Bureau of Indian Affairs must issue a written decision upholding or reversing the BIA Regional Director's disapproval. This decision must include a detailed written explanation of the reasons for the disapproval... reaching the decision (other than the tribe's request or notice of appeal), and notice of the tribe's right...

  9. [Research of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acid derivatives].

    PubMed

    Anisimova, V A; Tolpygin, I E; Spasov, A A; Serdiuk, T S; Sukhov, A G

    2011-01-01

    Ethyl esters of (9-subtituted-imidazo[1,2-a]benzimidazolyl-2)acetic acids were synthesized. The chemical properties of these esters (hydrolysis, decarboxylation, hydrazinolysis) and biological activity (fungicidal, antimicrobial, antiarrhythmic activity, and also affects on the brain rhythmogenesis) of the prepared compounds were studied.

  10. Cellulose Acetate/N-TiO2 Biocomposite Flexible Films with Enhanced Solar Photochromic Properties

    NASA Astrophysics Data System (ADS)

    Radhika, T.; Anju, K. R.; Silpa, M. S.; Ramalingam, R. Jothi; Al-Lohedan, Hamad A.

    2017-07-01

    Flexible cellulose acetate/N-TiO2 nanocomposite films containing various concentrations of nanosized N-TiO2 and an intelligent methylene blue ink have been prepared by solution casting. The hydrothermally prepared nitrogen-doped titania (N-TiO2) and the films were characterized in detail. The photochromic properties of the prepared films were investigated under ultraviolet (UV), visible light, and simulated solar irradiation by UV-Vis spectrophotometry. Upon irradiation, the films exhibited rapid photochromic response that was reversible at room temperature. Films with higher content of nano N-TiO2 showed enhanced decoloration/recoloration under all irradiation conditions, with fast decoloration/recoloration under simulated solar irradiation. These results suggest that the amount of nano N-TiO2 in the composite, the concentration of methylene blue, and the solvent greatly influence the photochromic properties of the films. Such flexible and transparent cellulose acetate/N-TiO2 films with enhanced decoloration/recoloration properties under solar irradiation are promising smart materials for use in photoreversible printed electronics applications.

  11. Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism

    DOEpatents

    Gaddy, James L.; Clausen, Edgar C.

    1992-01-01

    A newly discovered microorganism was isolated in a biologically pure culture and designated Clostridium ljungdahlii, having the identifying characteristics of ATCC No. 49587. Cultured in an aqueous nutrient medium under anaerobic conditions, this microorganism is capable of producing ethanol and acetate from CO and H.sub.2 O and/or CO.sub.2 and H.sub.2 in synthesis gas. Under optimal growth conditions, the microorganism produces acetate in preference to ethanol. Conversely, under non-growth conditions, ethanol production is favored over acetate.

  12. 25 CFR 103.19 - When must the lender pay BIA the loan guaranty or insurance premium?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... insurance premium? 103.19 Section 103.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY How a Lender Obtains a Loan Guaranty or Insurance Coverage § 103.19 When must the lender pay BIA the loan guaranty or insurance premium? The premium...

  13. 25 CFR 103.19 - When must the lender pay BIA the loan guaranty or insurance premium?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... insurance premium? 103.19 Section 103.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LOAN GUARANTY, INSURANCE, AND INTEREST SUBSIDY How a Lender Obtains a Loan Guaranty or Insurance Coverage § 103.19 When must the lender pay BIA the loan guaranty or insurance premium? The premium...

  14. 25 CFR 103.16 - How does BIA approve or reject a loan guaranty or insurance application?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... with this part, and whether there is a reasonable prospect of loan repayment from business cash flow... an approval letter, followed by the procedures in § 103.18. If the guaranty or insurance application... submits the missing information. If BIA denies the application, it will provide the lender with a written...

  15. 25 CFR 162.597 - Will BIA appeal bond regulations apply to cancellation decisions involving WSR leases?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will BIA appeal bond regulations apply to cancellation decisions involving WSR leases? 162.597 Section 162.597 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness...

  16. 25 CFR 162.597 - Will BIA appeal bond regulations apply to cancellation decisions involving WSR leases?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will BIA appeal bond regulations apply to cancellation decisions involving WSR leases? 162.597 Section 162.597 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Effectiveness...

  17. A set of new transition metal-based coordination complexes dependent upon Hpztza ligand (Hpztza=2-(5-(pyrazin-2-yl)-2H-tetrazol-2-yl) acetic acid)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang Jie; Shen Lei; Yang Gaowen, E-mail: ygwsx@126.com

    2012-02-15

    Reaction of MCl{sub 2}{center_dot}4H{sub 2}O (M=Zn, Cd, Mn, Co, Ni) with 2-(5-(pyrazin-2-yl)-2H-tetrazol-2-yl) acetic acid (Hpztza) yielded a set of new M(II)/pztza complexes, [Cd(pztza){sub 2}(H{sub 2}O){sub 6}]{center_dot}3H{sub 2}O{center_dot}(Hpztza) (1), [M(pztza){sub 2}(H{sub 2}O){sub 2}; M=Cd(2), Zn(7), Mn(9)], [Cd(pztza){sub 2}]{center_dot}2(CH{sub 3}OH) (3), [Co(pztza){sub 2}(H{sub 2}O){sub 2}]{center_dot}6H{sub 2}O (4), [Co(pztza)(H{sub 2}O)Cl] (6) and [M(pztza){sub 2}(H{sub 2}O){sub 2}]{center_dot}2H{sub 2}O [M=Co(5), Zn(8), Ni(10)]. These compounds were structurally characterized by elemental analysis, IR spectroscopy and X-ray single-crystal diffraction. Complex 1 featured a mononuclear structure, complexes 4, 5, 7, 8, 10 showed 1D chains and complexes 2, 3, 6, 9 displayed 2D layer structures. Furthermore, the luminescence propertiesmore » of 1-10 were investigated at room temperature in the solid state. - Graphical abstract: Ten new coordination polymers with 2-(5-(pyrazin-2-yl)-2H-tetrazol-2-yl) acetic acid (Hpztza) ligand have been synthesized and their structures have been characterized. All of the complexes show photoluminescence at room temperature. Highlights: Black-Right-Pointing-Pointer Ten novel transition metal-based coordination complexes with 2-(5-(pyrazin-2-yl)-2H-tetrazol-2-yl) acetic acid (Hpztza) are reported. Black-Right-Pointing-Pointer Complexes 1-10 are described as mononuclear structure, 1D and 2D frameworks with diverse architecture. Black-Right-Pointing-Pointer Six coordination complexes show emission at room temperature in the solid state.« less

  18. Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism

    DOEpatents

    Gaddy, J.L.; Clausen, E.C.

    1992-12-22

    A newly discovered microorganism was isolated in a biologically pure culture and designated Clostridium ljungdahlii, having the identifying characteristics of ATCC No. 49587. Cultured in an aqueous nutrient medium under anaerobic conditions, this microorganism is capable of producing ethanol and acetate from CO and H[sub 2]O and/or CO[sub 2] and H[sub 2] in synthesis gas. Under optimal growth conditions, the microorganism produces acetate in preference to ethanol. Conversely, under non-growth conditions, ethanol production is favored over acetate. 3 figs.

  19. Simultaneous determination of triacetin, acetic ether, butyl acetate and amorolfine hydrochloride in amorolfine liniment by HPLC.

    PubMed

    Gao, Yuan; Li, Li; Zhang, Jianjun; Shu, Wenjuan; Gao, Liqiong

    2012-04-01

    A simple, rapid, specific and precise reversed-phase high-performance liquid chromatographic method was developed for simultaneous estimation of triacetin, acetic ether, butyl acetate and amorolfine in marketed pharmaceutical liniment. Chromatographic separation was performed on a Shimadzu VP-ODS C(18) column using the mixture of citric acid-hydrochloric acid-sodium hydrate buffer (pH 3.0), acetonitrile and methanol (32:30:38) as the mobile phase at a flow rate of 1.0 mL/min with UV-detection at 215 nm. The method separated the four components simultaneously in less than 10 min. The validation of the method was performed with respect to specificity, linearity, accuracy, and precision. The calibration curves were linear in the range of 35.1-81.9 μ/mL for triacetin, 431.1-1005.9 μ/mL for acetic ether, 167.0-389.7 μ/mL for butyl acetate and 151.0-352.3 μ/mL for amorolfine. The mean 100% spiked recovery for triacetin, acetic ether, butyl acetate and amorolfine is 99.43 ± 0.42, 101.5 ± 1.09, 101.4 ± 1.02 and 100.8 ± 0.69, respectively. The intra-day and inter-day relative standard deviation values were <2.0%. The limits of detection of these compounds ranged from 0.08 to 5.88 ng. The utility of the procedure was verified by its application to the commercial liniment.

  20. Native defect-assisted enhanced response to CH4 near room temperature by Al0.07Ga0.93N nanowires.

    PubMed

    Parida, Santanu; Das, A; Prasad, Arun K; Ghatak, Jay; Dhara, Sandip

    2018-06-26

    Gas sensors at low operating temperature with high sensitivity require group III nitrides owing to their high chemical and thermal stabilities. For the first time, Al0.07Ga0.93N nanowires (NWs) have been utilized in CH4 sensing, and it has been demonstrated that they exhibit an improved response compared to GaN NWs at the low operating temperature of 50 °C. Al0.07Ga0.93N NWs have been synthesized via the ion beam mixing process using inert gas ion irradiation on the bilayer of Al/GaN NWs. The sensing mechanism is explained with the help of native defects present in the system. The number of shallow acceptors created by Ga vacancies (VGa) is found to be higher in Al0.07Ga0.93N NWs than in as-grown GaN NWs. The role of the O antisite defect (ON) for the formation of shallow VGa is inferred from photoluminescence spectroscopic analysis. These native defects strongly influence the gas sensing behaviour, which results in enhanced and low-temperature CH4 sensing.

  1. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

    PubMed

    Yu, Gang; Praveen Rao, P N; Chowdhury, Morshed A; Abdellatif, Khaled R A; Dong, Ying; Das, Dipankar; Velázquez, Carlos A; Suresh, Mavanur R; Knaus, Edward E

    2010-04-01

    A new group of acetic acid (7a-c, R(1) = H), and propionic acid (7d-f, R(1) = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is attached via its C-3, C-4, and C-5 position was synthesized. This group of compounds exhibited a more potent inhibition, and hence selectivity, for the cyclooxygenase-2 (COX-2) relative to the COX-1 isozyme. Attachment of the N-difluoromethyl-1,2-dihydropyrid-2-one ring system to an acetic acid, or propionic acid, moiety confers potent 5-LOX inhibitory activity, that is, absent in traditional arylacetic acid NSAIDs. 2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid (7c) exhibited the best combination of dual COX-2 and 5-LOX inhibitory activities. Molecular modeling (docking) studies showed that the highly electronegative CHF(2) substituent present in 7c, that showed a modest selectivity for the COX-2 isozyme, is oriented within the secondary pocket (Val523) present in COX-2 similar to the sulfonamide (SO(2)NH(2)) COX-2 pharmacophore present in celecoxib, and that the N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore is oriented close to the region containing the LOX enzyme catalytic iron (His361, His366, and His545). Accordingly, the N-difluoromethyl-1,2-dihyrdopyrid-2-one moiety possesses properties suitable for the design of dual COX-2/5-LOX inhibitory drugs. 2010 Elsevier Ltd. All rights reserved.

  2. 25 CFR 161.713 - How will BIA determine the amount of damages to Navajo Partitioned Lands?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will BIA determine the amount of damages to Navajo Partitioned Lands? 161.713 Section 161.713 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161.713...

  3. Effect of surface oxygen vacancy sites on ethanol synthesis from acetic acid hydrogenation on a defective In2O3(110) surface.

    PubMed

    Lyu, Huisheng; Liu, Jiatao; Chen, Yifei; Li, Guiming; Jiang, Haoxi; Zhang, Minhua

    2018-03-07

    Developing a new type of low-cost and high-efficiency non-noble metal catalyst is beneficial for industrially massive synthesis of alcohols from carboxylic acids which can be obtained from renewable biomass. In this work, the effect of active oxygen vacancies on ethanol synthesis from acetic acid hydrogenation over defective In 2 O 3 (110) surfaces has been studied using periodic density functional theory (DFT) calculations. The relative stabilities of six surface oxygen vacancies from O v1 to O v6 on the In 2 O 3 (110) surface were compared. D1 and D4 surfaces with respective O v1 and O v4 oxygen vacancies were chosen to map out the reaction paths from acetic acid to ethanol. A reaction cycle mechanism between the perfect and defective states of the In 2 O 3 surface was found to catalyze the formation of ethanol from acetic acid hydrogenation. By H 2 reduction the oxygen vacancies on the In 2 O 3 surface play key roles in promoting CH 3 COO* hydrogenation and C-O bond breaking in acetic acid hydrogenation. The acetic acid, in turn, benefits the creation of oxygen vacancies, while the C-O bond breaking of acetic acid refills the oxygen vacancy and, thereby, sustains the catalytic cycle. The In 2 O 3 based catalysts were shown to be advantageous over traditional noble metal catalysts in this paper by theoretical analysis.

  4. 25 CFR 10.6 - How is the BIA assured that the policies and standards are being applied uniformly and facilities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-mandatory detention standards and will document progress on uniform reporting. The BIA Office of Law... OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY DETENTION FACILITIES AND...

  5. [Acetate-free biofiltration].

    PubMed

    Martello, Mauro; Di Luca, Marina

    2012-01-01

    Acetate-free biofiltration is a dialysis method with high biocompatibility. The lack of acetate results in decreased stimulation of the production of inflammatory mediators. Other favorable features have been added over the years, such as the possibility to modulate the concentration of potassium in the dialysate, thereby reducing the risk of arrhythmias; the possibility to constantly monitor the blood volume during treatment to reduce the risk of intradialytic hypotension; and a reduced need for heparin thanks to a membrane with a specially treated surface. In this review we discuss the specifics of acetate-free biofiltration.

  6. Acetic acid production from food wastes using yeast and acetic acid bacteria micro-aerobic fermentation.

    PubMed

    Li, Yang; He, Dongwei; Niu, Dongjie; Zhao, Youcai

    2015-05-01

    In this study, yeast and acetic acid bacteria strains were adopted to enhance the ethanol-type fermentation resulting to a volatile fatty acids yield of 30.22 g/L, and improve acetic acid production to 25.88 g/L, with food wastes as substrate. In contrast, only 12.81 g/L acetic acid can be obtained in the absence of strains. The parameters such as pH, oxidation reduction potential and volatile fatty acids were tested and the microbial diversity of different strains and activity of hydrolytic ferment were investigated to reveal the mechanism. The optimum pH and oxidation reduction potential for the acetic acid production were determined to be at 3.0-3.5 and -500 mV, respectively. Yeast can convert organic matters into ethanol, which is used by acetic acid bacteria to convert the organic wastes into acetic acid. The acetic acid thus obtained from food wastes micro-aerobic fermentation liquid could be extracted by distillation to get high-pure acetic acid.

  7. Overview on mechanisms of acetic acid resistance in acetic acid bacteria.

    PubMed

    Wang, Bin; Shao, Yanchun; Chen, Fusheng

    2015-02-01

    Acetic acid bacteria (AAB) are a group of gram-negative or gram-variable bacteria which possess an obligate aerobic property with oxygen as the terminal electron acceptor, meanwhile transform ethanol and sugar to corresponding aldehydes, ketones and organic acids. Since the first genus Acetobacter of AAB was established in 1898, 16 AAB genera have been recorded so far. As the main producer of a world-wide condiment, vinegar, AAB have evolved an elegant adaptive system that enables them to survive and produce a high concentration of acetic acid. Some researches and reviews focused on mechanisms of acid resistance in enteric bacteria and made the mechanisms thoroughly understood, while a few investigations did in AAB. As the related technologies with proteome, transcriptome and genome were rapidly developed and applied to AAB research, some plausible mechanisms conferring acetic acid resistance in some AAB strains have been published. In this review, the related mechanisms of AAB against acetic acid with acetic acid assimilation, transportation systems, cell morphology and membrane compositions, adaptation response, and fermentation conditions will be described. Finally, a framework for future research for anti-acid AAB will be provided.

  8. NuSTAR Hard X-Ray Observation of the Gamma-Ray Binary Candidate HESS J1832-093

    NASA Astrophysics Data System (ADS)

    Mori, Kaya; Gotthelf, E. V.; Hailey, Charles J.; Hord, Ben J.; de Oña Wilhelmi, Emma; Rahoui, Farid; Tomsick, John A.; Zhang, Shuo; Hong, Jaesub; Garvin, Amani M.; Boggs, Steven E.; Christensen, Finn E.; Craig, William W.; Harrison, Fiona A.; Stern, Daniel; Zhang, William W.

    2017-10-01

    We present a hard X-ray observation of the TeV gamma-ray binary candidate HESS J1832-093, which is coincident with the supernova remnant G22.7-0.2, using the Nuclear Spectroscopic Telescope Array. Non-thermal X-ray emission from XMMU J183245-0921539, the X-ray source associated with HESS J1832-093, is detected up to ˜30 keV and is well-described by an absorbed power-law model with a best-fit photon index {{Γ }}=1.5+/- 0.1. A re-analysis of archival Chandra and XMM-Newton data finds that the long-term X-ray flux increase of XMMU J183245-0921539 is {50}-20+40 % (90% C.L.), much less than previously reported. A search for a pulsar spin period or binary orbit modulation yields no significant signal to a pulse fraction limit of {f}p< 19 % in the range 4 ms < P< 40 ks. No red noise is detected in the FFT power spectrum to suggest active accretion from a binary system. While further evidence is required, we argue that the X-ray and gamma-ray properties of XMMU J183245-0921539 are most consistent with a non-accreting binary generating synchrotron X-rays from particle acceleration in the shock formed as a result of the pulsar and stellar wind collision. We also report on three nearby hard X-ray sources, one of which may be associated with diffuse emission from a fast-moving supernova fragment interacting with a dense molecular cloud.

  9. 25 CFR 1000.72 - Will OSG notify Tribes/Consortia and affected non-BIA bureaus of the results of the selection...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.72 Will OSG...

  10. In situ oligomerization of 2-(thiophen-3-yl)acetate intercalated into Zn{sub 2}Al layered double hydroxide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tronto, Jairo, E-mail: jairotronto@ufv.br; Pinto, Frederico G.; Costa, Liovando M. da

    2015-01-15

    A layered double hydroxide (LDH) with cation composition Zn{sub 2}Al was intercalated with 2-(thiophen-3-yl)acetate (3-TA) monomers. To achieve in situ polymerization and/or oligomerization of the intercalated monomers, soft thermal treatments were carried out, and subsequent hybrid LDH materials were analyzed by means of several characterization techniques using powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), {sup 13}C CP–MAS nuclear magnetic resonance (NMR), electron spin resonance (EPR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM), inductively coupled plasma optical emission spectroscopy (ICP–OES), and elemental analysis. PXRD analysis suggested that the intercalated monomers formed a bilayer. Thermalmore » treatment of the hybrid LDH assembly above 120 °C provokes partially the breakdown of the layered structure, generating the phase zincite. EPR results indicated that vicinal monomers (oligomerization) were bound to each other after hydrothermal or thermal treatment, leading to a polaron response characteristic of electron conductivity localized on a restricted number of thiophene-based monomer segments. Localized unpaired electrons exist in the material and interact with the {sup 27}Al nuclei of the LDH layers by superhyperfine coupling. These unpaired electrons also interact with the surface of ZnO (O{sup 2−} vacancies), formed during the thermal treatments. - Graphical abstract: We synthesized a layered double hydroxide (LDH) with cation composition Zn{sub 2}Al, intercalated with 2-(thiophen-3-yl)acetate (3-TA) monomers, by coprecipitation at constant pH. We thermally treated the material, to achieve in situ polymerization and/or oligomerization of the intercalated monomers. - Highlights: • A Zn{sub 2}Al–LDH was intercalated with 2-(thiophen-3-yl)acetate monomers. • To achieve in situ oligomerization of the monomers, thermal treatments were

  11. 25 CFR 166.816 - How will the BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... enforcement of the trespass? 166.816 Section 166.816 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.816 How will the BIA determine the costs associated with enforcement of the trespass? Costs of enforcement may include detection...

  12. 25 CFR 166.816 - How will the BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... enforcement of the trespass? 166.816 Section 166.816 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.816 How will the BIA determine the costs associated with enforcement of the trespass? Costs of enforcement may include detection...

  13. 25 CFR 166.816 - How will the BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... enforcement of the trespass? 166.816 Section 166.816 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.816 How will the BIA determine the costs associated with enforcement of the trespass? Costs of enforcement may include detection...

  14. 25 CFR 166.816 - How will the BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... enforcement of the trespass? 166.816 Section 166.816 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.816 How will the BIA determine the costs associated with enforcement of the trespass? Costs of enforcement may include detection...

  15. 25 CFR 166.816 - How will the BIA determine the costs associated with enforcement of the trespass?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... enforcement of the trespass? 166.816 Section 166.816 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Trespass Penalties, Damages, and Costs § 166.816 How will the BIA determine the costs associated with enforcement of the trespass? Costs of enforcement may include detection...

  16. 25 CFR 115.604 - When will BIA authorize OTFM to place a restriction on your IIM account?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false When will BIA authorize OTFM to place a restriction on your IIM account? 115.604 Section 115.604 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for...

  17. 25 CFR 115.604 - When will BIA authorize OTFM to place a restriction on your IIM account?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When will BIA authorize OTFM to place a restriction on your IIM account? 115.604 Section 115.604 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for...

  18. 25 CFR 115.604 - When will BIA authorize OTFM to place a restriction on your IIM account?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When will BIA authorize OTFM to place a restriction on your IIM account? 115.604 Section 115.604 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for...

  19. 25 CFR 115.604 - When will BIA authorize OTFM to place a restriction on your IIM account?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false When will BIA authorize OTFM to place a restriction on your IIM account? 115.604 Section 115.604 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for...

  20. 25 CFR 115.604 - When will BIA authorize OTFM to place a restriction on your IIM account?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true When will BIA authorize OTFM to place a restriction on your IIM account? 115.604 Section 115.604 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for...

  1. Relative Reactivity Measurements of Stabilized CH2OO, Produced by Ethene Ozonolysis, Toward Acetic Acid and Water Vapor Using Chemical Ionization Mass Spectrometry.

    PubMed

    Yajima, Ryoji; Sakamoto, Yosuke; Inomata, Satoshi; Hirokawa, Jun

    2017-08-31

    We investigated the relative reactivity of stabilized CH 2 OO, produced by ethene ozonolysis, toward acetic acid and water vapor at a temperature of 298 ± 2 K and atmospheric pressure. Hydroperoxymethyl acetate produced through the reaction between stabilized CH 2 OO and acetic acid was monitored using a chemical ionization mass spectrometer as a function of the acetic acid concentration at different relative humidities. The rate of the reaction between CH 2 OO and water vapor depended quadratically on the water vapor concentration, suggesting that CH 2 OO reacted with water dimers in preference to water monomers. We obtained the bimolecular rate constant for the reaction between CH 2 OO and water dimer relative to the rate constant for the reaction between CH 2 OO and acetic acid, k 3 /k 1 , of (6.3 ± 0.4) × 10 -2 . The k 3 value of (8.2 ± 0.8) × 10 -12 cm 3 molecule -1 s -1 was derived by combining with a k 1 value of (1.3 ± 0.1) × 10 -10 cm 3 molecule -1 s -1 , which has been previously reported by direct kinetic studies. The k 3 value thus obtained is consistent with the absolute rate constants measured directly, suggesting that the reactivity of CH 2 OO is irrespective of the CH 2 OO generation method, namely, ethene ozonolysis or diiodomethane photolysis. We indirectly determined the yield of stabilized CH 2 OO from the ozonolysis of ethene of 0.59 ± 0.17 and 0.55 ± 0.16 under dry and humid (relative humidity 23-24%) conditions, respectively, suggesting that the yield is independent of the water vapor concentration. Our results suggest that hydroperoxymethyl acetate is the sole product of the reaction between stabilized CH 2 OO and acetic acid. The approach presented here can likely be extended to studies of the reactivities of more complicated and atmospherically relevant stabilized Criegee intermediates.

  2. 25 CFR 115.607 - How do you request a hearing to challenge the BIA's decision to restrict your IIM account?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... decision and notified you of the restriction. Your request must: (a) Be in writing; (b) Specifically request a hearing to challenge the restriction; and (c) Be hand delivered to the BIA office or postmarked...

  3. 25 CFR 115.617 - What happens when the BIA decides to supervise or encumber your IIM account after your hearing?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.617 What happens when the BIA decides to supervise or...

  4. 25 CFR 115.607 - How do you request a hearing to challenge the BIA's decision to restrict your IIM account?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.607 How do you request a hearing to challenge the BIA...

  5. 25 CFR 115.607 - How do you request a hearing to challenge the BIA's decision to restrict your IIM account?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.607 How do you request a hearing to challenge the BIA...

  6. 25 CFR 115.617 - What happens when the BIA decides to supervise or encumber your IIM account after your hearing?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.617 What happens when the BIA decides to supervise or...

  7. 25 CFR 115.617 - What happens when the BIA decides to supervise or encumber your IIM account after your hearing?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.617 What happens when the BIA decides to supervise or...

  8. 25 CFR 115.607 - How do you request a hearing to challenge the BIA's decision to restrict your IIM account?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.607 How do you request a hearing to challenge the BIA...

  9. 25 CFR 115.607 - How do you request a hearing to challenge the BIA's decision to restrict your IIM account?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.607 How do you request a hearing to challenge the BIA...

  10. 25 CFR 115.617 - What happens when the BIA decides to supervise or encumber your IIM account after your hearing?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.617 What happens when the BIA decides to supervise or...

  11. 25 CFR 115.617 - What happens when the BIA decides to supervise or encumber your IIM account after your hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.617 What happens when the BIA decides to supervise or...

  12. Effect of acetic acid on lipid accumulation by glucose-fed activated sludge cultures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mondala, Andro; Hernandez, Rafael; French, Todd

    2012-01-01

    The effect of acetic acid, a lignocellulose hydrolysis by-product, on lipid accumulation by activated sludge cultures grown on glucose was investigated. This was done to assess the possible application of lignocellulose as low-cost and renewable fermentation substrates for biofuel feedstock production. Results: Biomass yield was reduced by around 54% at a 2 g L -1 acetic acid dosage but was increased by around 18% at 10 g L -1 acetic acid dosage relative to the control run. The final gravimetric lipid contents at 2 and 10 g L -1 acetic acid levels were 12.5 + 0.7% and 8.8 + 3.2%more » w/w, respectively, which were lower than the control (17.8 + 2.8% w/w). However, biodiesel yields from activated sludge grown with acetic acid (5.6 + 0.6% w/w for 2 g L -1 acetic acid and 4.2 + 3.0% w/w for 10 g L -1 acetic acid) were higher than in raw activated sludge (1-2% w/w). The fatty acid profiles of the accumulated lipids were similar with conventional plant oil biodiesel feedstocks. Conclusions: Acetic acid enhanced biomass production by activated sludge at high levels but reduced lipid production. Further studies are needed to enhance acetic acid utilization by activated sludge microorganisms for lipid biosynthesis.« less

  13. Acetobacter pasteurianus metabolic change induced by initial acetic acid to adapt to acetic acid fermentation conditions.

    PubMed

    Zheng, Yu; Zhang, Renkuan; Yin, Haisong; Bai, Xiaolei; Chang, Yangang; Xia, Menglei; Wang, Min

    2017-09-01

    Initial acetic acid can improve the ethanol oxidation rate of acetic acid bacteria for acetic acid fermentation. In this work, Acetobacter pasteurianus was cultured in ethanol-free medium, and energy production was found to increase by 150% through glucose consumption induced by initial acetic acid. However, oxidation of ethanol, instead of glucose, became the main energy production pathway when upon culturing ethanol containing medium. Proteome assay was used to analyze the metabolism change induced by initial acetic acid, which provided insight into carbon metabolic and energy regulation of A. pasteurianus to adapt to acetic acid fermentation conditions. Results were further confirmed by quantitative real-time PCR. In summary, decreased intracellular ATP as a result of initial acetic acid inhibition improved the energy metabolism to produce more energy and thus adapt to the acetic acid fermentation conditions. A. pasteurianus upregulated the expression of enzymes related to TCA and ethanol oxidation to improve the energy metabolism pathway upon the addition of initial acetic acid. However, enzymes involved in the pentose phosphate pathway, the main pathway of glucose metabolism, were downregulated to induce a change in carbon metabolism. Additionally, the enhancement of alcohol dehydrogenase expression promoted ethanol oxidation and strengthened the acetification rate, thereby producing a strong proton motive force that was necessary for energy production and cell tolerance to acetic acid.

  14. 25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108 Indians BUREAU... Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be: (1) Developed...

  15. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... property, including your financial affairs;” or (3) Determines through an administrative process that you..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.601 Under what circumstances may the BIA restrict...

  16. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... property, including your financial affairs;” or (3) Determines through an administrative process that you..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.601 Under what circumstances may the BIA restrict...

  17. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... property, including your financial affairs;” or (3) Determines through an administrative process that you..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.601 Under what circumstances may the BIA restrict...

  18. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... property, including your financial affairs;” or (3) Determines through an administrative process that you..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.601 Under what circumstances may the BIA restrict...

  19. 25 CFR 161.717 - What happens if BIA does not collect enough money to satisfy the penalty?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What happens if BIA does not collect enough money to satisfy the penalty? 161.717 Section 161.717 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161...

  20. 25 CFR 170.435 - How does BIA or the tribe determine the need for a public hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA or the tribe determine the need for a public hearing? 170.435 Section 170.435 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads...

  1. Smartphone-Based Bioelectrical Impedance Analysis Devices for Daily Obesity Management

    PubMed Central

    Choi, Ahyoung; Kim, Justin Younghyun; Jo, Seongwook; Jee, Jae Hwan; Heymsfield, Steven B.; Bhagat, Yusuf A.; Kim, Insoo; Cho, Jaegeol

    2015-01-01

    Current bioelectric impedance analysis (BIA) systems are often large, cumbersome devices which require strict electrode placement on the user, thus inhibiting mobile capabilities. In this work, we developed a handheld BIA device that measures impedance from multiple frequencies (5 kHz~200 kHz) with four contact electrodes and evaluated the BIA device against standard body composition analysis systems: a dual-energy X-ray absorptiometry (DXA) system (GE Lunar Prodigy, GE Healthcare, Buckinghamshire, UK) and a whole-body BIA system (InBody S10, InBody, Co. Ltd, Seoul, Korea). In the study, 568 healthy participants, varying widely in body mass index, age, and gender, were recruited at two research centers: the Samsung Medical Center (SMC) in South Korea and the Pennington Biomedical Research Center (PBRC) in the United States. From the measured impedance data, we analyzed individual body fat and skeletal muscle mass by applying linear regression analysis against target reference data. Results indicated strong correlations of impedance measurements between the prototype pathways and corresponding InBody S10 electrical pathways (R = 0.93, p < 0.0001). Additionally, body fat estimates from DXA did not yield significant differences (p > 0.728 (paired t-test), DXA mean body fat 29.45 ± 10.77 kg, estimated body fat 29.52 ± 12.53 kg). Thus, this portable BIA system shows a promising ability to estimate an individual’s body composition that is comparable to large stationary BIA systems. PMID:26364636

  2. 21 CFR 177.1360 - Ethylene-vinyl acetate-vinyl alcohol copolymers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Ethylene-vinyl acetate-vinyl alcohol copolymers... for Use as Basic Components of Single and Repeated Use Food Contact Surfaces § 177.1360 Ethylene-vinyl acetate-vinyl alcohol copolymers. Ethylene-vinyl acetate-vinyl alcohol copolymers (CAS Reg. No. 26221-27-2...

  3. Divergent Syntheses of Isoquinolines and Indolo[1,2-a]quinazolines by Copper-Catalyzed Cascade Annulation from 2-Haloaryloxime Acetates with Active Methylene Compounds and Indoles.

    PubMed

    Jiang, Huanfeng; Yang, Jidan; Tang, Xiaodong; Wu, Wanqing

    2016-03-04

    A convenient and reliable method for the direct construction of isoquinolines is described. A series of isoquinoline derivatives were synthesized, with high chemo- and regioselectivities, via the copper-catalyzed cascade reaction of 2-haloaryloxime acetates with β-diketones, β-keto esters, and β-keto nitriles. This tandem annulation process features inexpensive catalysts, no need for additional ligands, and excellent functional group tolerance, which makes it have potential synthetic applications. Furthermore, this strategy could also be used to enter functionalized indolo[1,2-a]quinazolines by using indoles as the counterpart of the 2-haloaryloxime acetates.

  4. Investigation of gel formation and volatilization of acetate acid in magnesium acetate droplets by the optical tweezers

    NASA Astrophysics Data System (ADS)

    Lv, Xi-Juan; Wang, Yang; Cai, Chen; Pang, Shu-Feng; Ma, Jia-Bi; Zhang, Yun-Hong

    2018-07-01

    Hygroscopicity and volatility of single magnesium acetate (MgAc2) aerosol particles at various relative humidities (RHs) are studied by a single-beam optical tweezers, and refractive indices (RIs) and morphology are characterized by cavity enhanced Raman spectroscopy. Gel formation and volatilization of acetate acid (HAc) in MgAc2 droplets are observed. Due to the formation of amorphous gel structure, water transposition in droplets at RH < 50% is significantly impeded on a time scale of 140,000 s. Different phase transition at RH < 10% is proposed to explain the distinct water loss after the gel formation. To compare volatilization of HAc in different systems, MgAc2 and sodium acetate (NaAc) droplets are maintained at several different stable RHs during up to 86,000 s. At RH ≈ 74%, magnesium hydroxide (Mg(OH)2) inclusions are formed in MgAc2 droplets due to the volatilization of HAc, and whispering gallery modes (WGMs) of MgAc2 droplets in the Raman spectrum quench after 50,000 s. In sharp contrast, after 86,000 s at RH ≈ 70%, NaAc droplets are in well-mixed liquid states, containing soluble sodium hydroxide (NaOH). At this state, the RI of NaAc droplet is increased, and the quenching of WGMs is not observable.

  5. Role of the Cu-ZrO 2 Interfacial Sites for Conversion of Ethanol to Ethyl Acetate and Synthesis of Methanol from CO 2 and H 2 [The Role of the Cu-ZrO 2 Interfacial Sites for Ethanol Conversion to Ethyl Acetate and Methanol Synthesis from CO 2 and H 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ro, Insoo; Liu, Yifei; Ball, Madelyn R.

    Well-defined Cu catalysts containing different amounts of zirconia were synthesized by controlled surface reactions (CSRs) and atomic layer deposition methods and studied for the selective conversion of ethanol to ethyl acetate and for methanol synthesis. Selective deposition of ZrO 2 on undercoordinated Cu sites or near Cu nanoparticles via the CSR method was evidenced by UV–vis absorption spectroscopy, scanning transmission electron microscopy, and inductively coupled plasma absorption emission spectroscopy. The concentrations of Cu and Cu-ZrO 2 interfacial sites were quantified using a combination of subambient CO Fourier transform infrared spectroscopy and reactive N 2O chemisorption measurements. The oxidation states ofmore » the Cu and ZrO 2 species for these catalysts were determined using X-ray absorption near edge structure measurements, showing that these species were present primarily as Cu 0 and Zr 4+, respectively. Here, it was found that the formation of Cu-ZrO 2 interfacial sites increased the turnover frequency by an order of magnitude in both the conversion of ethanol to ethyl acetate and the synthesis of methanol from CO 2 and H 2.« less

  6. Role of the Cu-ZrO 2 Interfacial Sites for Conversion of Ethanol to Ethyl Acetate and Synthesis of Methanol from CO 2 and H 2 [The Role of the Cu-ZrO 2 Interfacial Sites for Ethanol Conversion to Ethyl Acetate and Methanol Synthesis from CO 2 and H 2

    DOE PAGES

    Ro, Insoo; Liu, Yifei; Ball, Madelyn R.; ...

    2016-09-06

    Well-defined Cu catalysts containing different amounts of zirconia were synthesized by controlled surface reactions (CSRs) and atomic layer deposition methods and studied for the selective conversion of ethanol to ethyl acetate and for methanol synthesis. Selective deposition of ZrO 2 on undercoordinated Cu sites or near Cu nanoparticles via the CSR method was evidenced by UV–vis absorption spectroscopy, scanning transmission electron microscopy, and inductively coupled plasma absorption emission spectroscopy. The concentrations of Cu and Cu-ZrO 2 interfacial sites were quantified using a combination of subambient CO Fourier transform infrared spectroscopy and reactive N 2O chemisorption measurements. The oxidation states ofmore » the Cu and ZrO 2 species for these catalysts were determined using X-ray absorption near edge structure measurements, showing that these species were present primarily as Cu 0 and Zr 4+, respectively. Here, it was found that the formation of Cu-ZrO 2 interfacial sites increased the turnover frequency by an order of magnitude in both the conversion of ethanol to ethyl acetate and the synthesis of methanol from CO 2 and H 2.« less

  7. Isolation and Characterization of Acetate-Utilizing Anaerobes from a Freshwater Sediment.

    PubMed

    Scholten, J.C.M.; Stams, A.J.M.

    2000-12-01

    Acetate-degrading anaerobic microorganisms in freshwater sediment were quantified by the most probable number technique. From the highest dilutions a methanogenic, a sulfate-reducing, and a nitrate-reducing microorganism were isolated with acetate as substrate. The methanogen (culture AMPB-Zg) was non-motile and rod-shaped with blunted ends (0.5-1 mm x 3-4 mm long). Doubling times with acetate at 30-35 degrees C were 5.6-8.1 days. The methanogen grew only on acetate. Analysis of the 16S rRNA sequence showed that AMPB-Zg is closely related to Methanosaeta concilii. The isolated sulfate-reducing bacterium (strain ASRB-Zg) was rod-shaped with pointed ends (0.5-0.7 mm x 1.5-3.5 mm long), weakly motile, spore forming, and gram positive. At the optimum growth temperature of 30 degrees C the doubling times with acetate were 3.9-5.3 days. The bacterium grew on a range of organic acids, such as acetate, butyrate, fumarate, and benzoate, but did not grow autotrophically with H2, CO2, and sulfate. The closest relative of strain ASRB-Zg is Desulfotomaculum acetoxidans. The nitrate-reducing bacterium (strain ANRB-Zg) was rod-shaped (0.5-0.7 mm x 0.7-1 mm long), weakly motile, and gram negative. Optimum growth with acetate occurred at 20-25 degrees C. The bacterium grew on a range of organic substrates, such as acetate, butyrate, lactate, and glucose, and did grow autotrophically with H2, CO2, and oxygen but not with nitrate. In the presence of acetate and nitrate, thiosulfate was oxidized to sulfate. Phylogenetically, the closest relative of strain ANRB-Zg is Variovorax paradoxus.

  8. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its...

  9. Acetic acid removal from corn stover hydrolysate using ethyl acetate and the impact on Saccharomyces cerevisiae bioethanol fermentation.

    PubMed

    Aghazadeh, Mahdieh; Ladisch, Michael R; Engelberth, Abigail S

    2016-07-08

    Acetic acid is introduced into cellulose conversion processes as a consequence of composition of lignocellulose feedstocks, causing significant inhibition of adapted, genetically modified and wild-type S. cerevisiae in bioethanol fermentation. While adaptation or modification of yeast may reduce inhibition, the most effective approach is to remove the acetic acid prior to fermentation. This work addresses liquid-liquid extraction of acetic acid from biomass hydrolysate through a pathway that mitigates acetic acid inhibition while avoiding the negative effects of the extractant, which itself may exhibit inhibition. Candidate solvents were selected using simulation results from Aspen Plus™, based on their ability to extract acetic acid which was confirmed by experimentation. All solvents showed varying degrees of toxicity toward yeast, but the relative volatility of ethyl acetate enabled its use as simple vacuum evaporation could reduce small concentrations of aqueous ethyl acetate to minimally inhibitory levels. The toxicity threshold of ethyl acetate, in the presence of acetic acid, was found to be 10 g L(-1) . The fermentation was enhanced by extracting 90% of the acetic acid using ethyl acetate, followed by vacuum evaporation to remove 88% removal of residual ethyl acetate along with 10% of the broth. NRRL Y-1546 yeast was used to demonstrate a 13% increase in concentration, 14% in ethanol specific production rate, and 11% ethanol yield. This study demonstrated that extraction of acetic acid with ethyl acetate followed by evaporative removal of ethyl acetate from the raffinate phase has potential to significantly enhance ethanol fermentation in a corn stover bioethanol facility. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:929-937, 2016. © 2016 American Institute of Chemical Engineers.

  10. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Subpt. G, App. A Appendix A to Subpart G—List of Activities Eligible for Funding Under BIA..., or purchasing of maintenance equipment. 13. Paying utilities cost for roadway lighting and traffic signals. 14. Purchasing maintenance materials. 15. Developing, implementing, and maintaining an IRR...

  11. Acetic acid fermentation of acetobacter pasteurianus: relationship between acetic acid resistance and pellicle polysaccharide formation.

    PubMed

    Kanchanarach, Watchara; Theeragool, Gunjana; Inoue, Taketo; Yakushi, Toshiharu; Adachi, Osao; Matsushita, Kazunobu

    2010-01-01

    Acetobacter pasteurianus strains IFO3283, SKU1108, and MSU10 were grown under acetic acid fermentation conditions, and their growth behavior was examined together with their capacity for acetic acid resistance and pellicle formation. In the fermentation process, the cells became aggregated and covered by amorphous materials in the late-log and stationary phases, but dispersed again in the second growth phase (due to overoxidation). The morphological change in the cells was accompanied by changes in sugar contents, which might be related to pellicle polysaccharide formation. To determine the relationship between pellicle formation and acetic acid resistance, a pellicle-forming R strain and a non-forming S strain were isolated, and their fermentation ability and acetic acid diffusion activity were compared. The results suggest that pellicle formation is directly related to acetic acid resistance ability, and thus is important to acetic acid fermentation in these A. pasteurianus strains.

  12. 25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

  13. 25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

  14. 25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

  15. 25 CFR 170.108 - Should Indian tribes and BIA consult with States' planning organizations and local governments in...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...' planning organizations and local governments in the development of their IRRTIP? 170.108 Section 170.108... § 170.108 Should Indian tribes and BIA consult with States' planning organizations and local governments in the development of their IRRTIP? Yes. (a) All regionally significant IRR Program projects must be...

  16. 25 CFR 171.500 - How does BIA determine the annual operation and maintenance assessment rate for the irrigation...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... costs needed for the reliable operation of the irrigation facility infrastructure; (8) Maintenance of a... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA determine the annual operation and... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND...

  17. Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance

    PubMed Central

    Ding, Jun; Holzwarth, Garrett; Penner, Michael H.; Patton-Vogt, Jana; Bakalinsky, Alan T.

    2015-01-01

    Acetic acid-mediated inhibition of the fermentation of lignocellulose-derived sugars impedes development of plant biomass as a source of renewable ethanol. In order to overcome this inhibition, the capacity of Saccharomyces cerevisiae to synthesize acetyl-CoA from acetic acid was increased by overexpressing ACS2 encoding acetyl-coenzyme A synthetase. Overexpression of ACS2 resulted in higher resistance to acetic acid as measured by an increased growth rate and shorter lag phase relative to a wild-type control strain, suggesting that Acs2-mediated consumption of acetic acid during fermentation contributes to acetic acid detoxification. PMID:25673654

  18. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its...

  19. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its...

  20. 25 CFR 115.605 - What information will the BIA include in its notice of the decision to restrict your IIM account?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.605 What information will the BIA include in its...

  1. BIA interpretation techniques for vegetation mapping using thematic mapper false color composites (interim report for San Carlos Reservation)

    USGS Publications Warehouse

    Bonner, W.J.; English, T.C.; Haas, R.H.; Feagan, T.R.; McKinley, R.A.

    1987-01-01

    The Bureau of Indian Affairs (BIA) is responsible for the natural resource management of approximately 52 million acres of Trust lands in the contiguous United States. The lands are distributed in a "patchwork" fashion throughout the country. Management responsibilities on these areas include: minerals, range, timber, fish and wildlife, agricultural, cultural, and archaeological resources. In an age of decreasing natural resources and increasing natural resource values, effective multiple resource management is critical. BIA has adopted a "systems approach" to natural resource management which utilizes Geographic Information System (GIS) technology. The GIS encompasses a continuum of spatial and relational data elements, and included functional capabilities such as: data collection, data entry, data base development, data analysis, data base management, display, and report generalization. In support of database development activities, BIA and BLM/TGS conducted a cooperative effort to investigate the potential of 1:100,000 scale Thematic Mapper (TM) False Color Composites (FCCs) for providing vegetation information suitable for input to the GIS and to later be incorporated as a generalized Bureau wide land cover map. Land cover information is critical as the majority of reservations currently have no land cover information in either map or digital form. This poster outlines an approach which includes the manual interpretation of land cover using TM FCCs, the digitizing of interpreted polygons, and the editing of digital data, used upon ground truthing exercises. An efficient and cost-effective methodology for generating large area land cover information is illustrated for the Mineral Strip area on the San Carlos Indian Reservation in Arizona. Techniques which capitalize on the knowledge of the local natural resources professionals, while minimizing machine processing requirements, are suggested.

  2. Granulocyte elastase, beta-thromboglobulin, and C3d during acetate or bicarbonate hemodialysis with Hemophan compared to a cellulose acetate membrane.

    PubMed

    Stegmayr, B G; Esbensen, K; Gutierrez, A; Lundberg, L; Nielsen, B; Stroemsaeter, C E; Wehle, B

    1992-01-01

    Twenty-two patients were dialysed in a cross-over design using Hemophan or cellulose acetate membranes. The dialysate buffer was acetate (n = 12) or bicarbonate (n = 10). Blood was sampled at 0, 15, 60 and 180 min and mean values were adjusted for changes in total protein in each sample. At 15 min during dialysis a decrease in leukocytes and platelets occurred with both membranes, irrespective of the buffer (Wilcoxon, p less than 0.006). During dialysis, increases were found in granulocyte elastase inhibitor complex (E- alpha 1-PI), beta-thromboglobulin and C3d. beta 2-microglobulin was not significantly changed in blood after dialysis with Hemophan or cellulose acetate membranes with bicarbonate buffer. Side effects were more pronounced at 180 min during dialysis with bicarbonate in patients using cellulose acetate than with Hemophan (p = 0.021, n = 8). Hemophan seemed to be more favourable than cellulose acetate membranes in regard to leukopenia and E- alpha 1-PI. The dialysate buffer may also alter membrane biocompatibility.

  3. A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery.

    PubMed

    Donnenfeld, Eric D; Holland, Edward J; Solomon, Kerry D; Fiore, Jay; Gobbo, Anthony; Prince, Jessica; Sandoval, Helga P; Shull, Emily R; Perry, Henry D

    2011-10-01

    To compare the effects of 2 corticosteroids on corneal thickness and visual acuity after cataract surgery. Multicenter, randomized, contralateral-eye, double-masked trial. Fifty-two patients (104 eyes) underwent bilateral phacoemulsification. The first eye randomly received difluprednate 0.05% or prednisolone acetate 1%; the fellow eye received the alternative. Before surgery, 7 doses were administered over 2 hours; 3 additional doses were given after surgery, before discharge. For the remainder of the day, corticosteroids were administered every 2 hours, then 4 times daily during week 1 and twice daily during week 2. Corneal pachymetry, visual acuity, and corneal edema were evaluated before surgery and at days 1, 15, and 30 after surgery. Endothelial cell counts were evaluated before surgery and at 30 days after surgery. Retinal thickness was evaluated before surgery and at 15 and 30 days after surgery. Corneal thickness at day 1 was 33 μm less in difluprednate-treated eyes (P = .026). More eyes were without corneal edema in the difluprednate group than in the prednisolone group at day 1 (62% vs 38%, respectively; P = .019). Uncorrected and best-corrected visual acuity at day 1 were significantly better with difluprednate than prednisolone by 0.093 logMAR lines (P = .041) and 0.134 logMAR lines (P < .001), respectively. Endothelial cell density was 195.52 cells/mm(2) higher in difluprednate-treated eyes at day 30 (P < .001). Retinal thickness at day 15 was 7.74 μm less in difluprednate-treated eyes (P = .011). In this high-dose pulsed-therapy regimen, difluprednate reduced inflammation more effectively than prednisolone acetate, resulting in more rapid return of vision. Difluprednate was superior at protecting the cornea and reducing macular thickening after cataract surgery. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. 25 CFR 162.573 - How will BIA decide whether to approve an amendment to a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve an amendment to a WSR lease? 162.573 Section 162.573 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Amendments § 162.573 How will...

  5. 25 CFR 162.577 - How will BIA decide whether to approve an assignment of a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve an assignment of a WSR lease? 162.577 Section 162.577 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Assignments § 162.577 How will...

  6. 25 CFR 162.573 - How will BIA decide whether to approve an amendment to a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve an amendment to a WSR lease? 162.573 Section 162.573 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Amendments § 162.573 How will...

  7. 25 CFR 162.577 - How will BIA decide whether to approve an assignment of a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve an assignment of a WSR lease? 162.577 Section 162.577 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Assignments § 162.577 How will...

  8. 25 CFR 115.601 - Under what circumstances may the BIA restrict your IIM account through supervision or an...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...: Hearing Process for Restricting an IIM Account § 115.601 Under what circumstances may the BIA restrict... property, including your financial affairs;” or (3) Determines through an administrative process that you are an adult in need of assistance based on a finding by a licensed medical or mental health...

  9. The Effects of Acetate Buffer Concentration on Lysozyme Solubility

    NASA Technical Reports Server (NTRS)

    Forsythe, Elizabeth L.; Pusey, Marc L.

    1996-01-01

    The micro-solubility column technique was employed to systematically investigate the effects of buffer concentration on tetragonal lysozyme solubility. While keeping the NaCl concentrations constant at 2%, 3%, 4%, 5% and 7%, and the pH at 4.0, we have studied the solubility of tetragonal lysozyme over an acetate buffer concentration range of 0.01M to 0.5M as a function of temperature. The lysozyme solubility decreased with increasing acetate concentration from 0.01M to 0.1M. This decrease may simply be due to the net increase in solvent ionic strength. Increasing the acetate concentration beyond 0.1M resulted in an increase in the lysozyme solubility, which reached a peak at - 0.3M acetate concentration. This increase was believed to be due to the increased binding of acetate to the anionic binding sites of lysozyme, preventing their occupation by chloride. In keeping with the previously observed reversal of the Hoffmeister series for effectiveness of anions in crystallizing lysozyme, acetate would be a less effective precipitant than chloride. Further increasing the acetate concentration beyond 0.3M resulted in a subsequent gradual decrease in the lysozyme solubility at all NaCl concentrations.

  10. Elevated acetate concentrations in the rhizosphere of Spartina alterniflora and potential influences on sulfate reduction

    NASA Technical Reports Server (NTRS)

    Hines, Mark E.; Tugel, Joyce B.; Giblin, A. E.; Banta, G. T.; Hobbie, J. E.

    1992-01-01

    Acetate is important in anaerobic metabolism of non-vegetated sediments but its role in salt marsh soils was not investigated thoroughly. Acetate concentrations, oxidation (C-14) and SO4(2-) reduction (S-35) were measured in S. alterniflora soils in NH and MA. Pore water from cores contained greater than 0.1 mM acetate and in some instances greater than 1.0 mM. Non-destructive samples contained less than 0.01 mM. Acetate was associated with roots and concentrations were highest during vegetative growth and varied with changes in plant physiology. Acetate turnover was very low whether whole core or slurry incubations were used. Radiotracers injected directly into soils yielded rates of SO4(2-) reduction and acetate oxidation not significantly different from core incubation techniques. Regardless of incubation method, acetate oxidation did not account for a significant percentage of SO4(2-) reduction. These results differ markedly from data for non-vegetated coastal sediments where acetate levels are low, oxidation rate constants are high and acetate oxidation rates greatly exceed rates of SO4(2-) reduction. The discrepancy between rates of acetate oxidation and SO4(2-) reduction in marsh soils may be due either to the utilization of substrates other than acetate by SO4(2-) reducers or artifacts associated with measurements of organic utilization by rhizosphere bacteria.

  11. Development of Bio-impedance Analyzer (BIA) for Body Fat Calculation

    NASA Astrophysics Data System (ADS)

    Riyadi, Munawar A.; Nugraha, A.; Santoso, M. B.; Septaditya, D.; Prakoso, T.

    2017-04-01

    Common weight scales cannot assess body composition or determine fat mass and fat-fress mass that make up the body weight. This research propose bio-impedance analysis (BIA) tool capable to body composition assessment. This tool uses four electrodes, two of which are used for 50 kHz sine wave current flow to the body and the rest are used to measure the voltage produced by the body for impedance analysis. Parameters such as height, weight, age, and gender are provided individually. These parameters together with impedance measurements are then in the process to produce a body fat percentage. The experimental result shows impressive repeatability for successive measurements (stdev ≤ 0.25% fat mass). Moreover, result on the hand to hand node scheme reveals average absolute difference of total subjects between two analyzer tools of 0.48% (fat mass) with maximum absolute discrepancy of 1.22% (fat mass). On the other hand, the relative error normalized to Omron’s HBF-306 as comparison tool reveals less than 2% relative error. As a result, the system performance offers good evaluation tool for fat mass in the body.

  12. Investigation of gel formation and volatilization of acetate acid in magnesium acetate droplets by the optical tweezers.

    PubMed

    Lv, Xi-Juan; Wang, Yang; Cai, Chen; Pang, Shu-Feng; Ma, Jia-Bi; Zhang, Yun-Hong

    2018-07-05

    Hygroscopicity and volatility of single magnesium acetate (MgAc 2 ) aerosol particles at various relative humidities (RHs) are studied by a single-beam optical tweezers, and refractive indices (RIs) and morphology are characterized by cavity enhanced Raman spectroscopy. Gel formation and volatilization of acetate acid (HAc) in MgAc 2 droplets are observed. Due to the formation of amorphous gel structure, water transposition in droplets at RH < 50% is significantly impeded on a time scale of 140,000 s. Different phase transition at RH < 10% is proposed to explain the distinct water loss after the gel formation. To compare volatilization of HAc in different systems, MgAc 2 and sodium acetate (NaAc) droplets are maintained at several different stable RHs during up to 86,000 s. At RH ≈ 74%, magnesium hydroxide (Mg(OH) 2 ) inclusions are formed in MgAc 2 droplets due to the volatilization of HAc, and whispering gallery modes (WGMs) of MgAc 2 droplets in the Raman spectrum quench after 50,000 s. In sharp contrast, after 86,000 s at RH ≈ 70%, NaAc droplets are in well-mixed liquid states, containing soluble sodium hydroxide (NaOH). At this state, the RI of NaAc droplet is increased, and the quenching of WGMs is not observable. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. 25 CFR 166.909 - What are my obligations to the BIA after I participate in an agriculture education program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... an agriculture education program? 166.909 Section 166.909 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.909 What are my obligations to the BIA after I participate in an agriculture...

  14. 25 CFR 166.909 - What are my obligations to the BIA after I participate in an agriculture education program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... an agriculture education program? 166.909 Section 166.909 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.909 What are my obligations to the BIA after I participate in an agriculture...

  15. 25 CFR 166.909 - What are my obligations to the BIA after I participate in an agriculture education program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... an agriculture education program? 166.909 Section 166.909 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.909 What are my obligations to the BIA after I participate in an agriculture...

  16. 25 CFR 166.909 - What are my obligations to the BIA after I participate in an agriculture education program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... an agriculture education program? 166.909 Section 166.909 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.909 What are my obligations to the BIA after I participate in an agriculture...

  17. 25 CFR 166.909 - What are my obligations to the BIA after I participate in an agriculture education program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... an agriculture education program? 166.909 Section 166.909 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GRAZING PERMITS Agriculture Education, Education Assistance, Recruitment, and Training § 166.909 What are my obligations to the BIA after I participate in an agriculture...

  18. 21 CFR 529.1003 - Flurogestone acetate-impregnated vaginal sponge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Flurogestone acetate-impregnated vaginal sponge... § 529.1003 Flurogestone acetate-impregnated vaginal sponge. (a) Specifications. Each vaginal sponge... ewes during their normal breeding season. (2) Limitations. Using applicator provided, insert sponge...

  19. 25 CFR 162.556 - Will BIA notify a lessee when a payment is due under a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will BIA notify a lessee when a payment is due under a WSR lease? 162.556 Section 162.556 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation...

  20. 25 CFR 162.556 - Will BIA notify a lessee when a payment is due under a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will BIA notify a lessee when a payment is due under a WSR lease? 162.556 Section 162.556 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease Monetary Compensation...

  1. 25 CFR 161.715 - What will BIA do if a trespasser fails to pay penalties, damages and costs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What will BIA do if a trespasser fails to pay penalties, damages and costs? 161.715 Section 161.715 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS Trespass Penalties, Damages, and Costs § 161...

  2. 25 CFR 170.437 - How must BIA or a tribe inform the public when no hearing is held?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How must BIA or a tribe inform the public when no hearing is held? 170.437 Section 170.437 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation...

  3. 25 CFR 162.587 - What happens if BIA disapproves an amendment, assignment, sublease, or leasehold mortgage of a...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What happens if BIA disapproves an amendment, assignment, sublease, or leasehold mortgage of a WSR lease? 162.587 Section 162.587 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease...

  4. 25 CFR 162.587 - What happens if BIA disapproves an amendment, assignment, sublease, or leasehold mortgage of a...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What happens if BIA disapproves an amendment, assignment, sublease, or leasehold mortgage of a WSR lease? 162.587 Section 162.587 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Lease...

  5. Inert Reassessment Document for Amyl Acetate

    EPA Pesticide Factsheets

    Both acetates have a number of industrial uses such as solvents for lacquers, paints, and inks. Pharmaceutically, ethyl acetate is a flavoring aid and amyl acetate is used in extraction of penicillin.

  6. Evaluation of 11C-acetate and 18F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma.

    PubMed

    Territo, Paul R; Maluccio, Mary; Riley, Amanda A; McCarthy, Brian P; Fletcher, James; Tann, Mark; Saxena, Romil; Skill, Nicholas J

    2015-05-16

    Hepatocellular carcinoma (HCC) remains a global health problem with unique diagnostic and therapeutic challenges, including difficulties in identifying the highest risk patients. Previous work from our lab has established the murine multidrug resistance-2 mouse (MDR2) model of HCC as a reasonable preclinical model that parallels the changes seen in human inflammatory associated HCC. The purpose of this study is to evaluate modalities of PET/CT in MDR2(-/-) mice in order to facilitate therapeutic translational studies from bench to bedside. 18F-FDG and 11C-acetate PET/CT was performed on 12 m MDR2(-/-) mice (n = 3/tracer) with HCC and 12 m MDR2(-/+) control mice (n = 3/tracer) without HCC. To compare PET/CT to biological markers of HCC and cellular function, serum alpha-fetoprotein (AFP), lysophosphatidic acid (LPA), cAMP and hepatic tumor necrosis factor α (TNFα) were quantified in 3-12 m MDR2(-/-) (n = 10) mice using commercially available ELISA analysis. To translate results in mice to patients 11C-acetate PET/CT was also performed in 8 patents suspected of HCC recurrence following treatment and currently on the liver transplant wait list. Hepatic18F-FDG metabolism was not significantly increased in MDR2(-/-) mice. In contrast, hepatic 11C-acetate metabolism was significantly elevated in MDR2(-/-) mice when compared to MDR2(-/+) controls. Serum AFP and LPA levels increased in MDR2(-/-) mice contemporaneous with the emergence of HCC. This was accompanied by a significant decrease in serum cAMP levels and an increase in hepatic TNFα. In patients suspected of HCC recurrence there were 5 true positives, 2 true negatives and 1 suspected false 11C-acetate negative. Hepatic 11C-acetate PET/CT tracks well with HCC in MDR2(-/-) mice and patients with underlying liver disease. Consequently 11C-acetate PET/CT is well suited to study (1) HCC emergence/progression in patients and (2) reduce animal numbers required to study new chemotherapeutics in murine models

  7. Megestrol acetate in patients with AIDS-related cachexia.

    PubMed

    Von Roenn, J H; Armstrong, D; Kotler, D P; Cohn, D L; Klimas, N G; Tchekmedyian, N S; Cone, L; Brennan, P J; Weitzman, S A

    1994-09-15

    To compare the effects of oral suspensions of megestrol acetate, 800 mg/d, and placebo on body weight in patients with acquired immunodeficiency syndrome (AIDS)-related weight loss. Randomized, double-blind, placebo-controlled trial. Outpatient community and university patient care setting. Consecutive patients with AIDS who had substantial weight loss and anorexia were enrolled. Of 271 patients, 270 and 195 were evaluable for safety and efficacy, respectively. Patients were randomly assigned to receive placebo or megestrol acetate (100 mg, 400 mg, or 800 mg) daily for 12 weeks. The primary efficacy criterion was weight gain. Patients were evaluated at 4-week intervals for changes in weight and body composition, caloric intake, sense of well-being, toxic effects, and appetite. For evaluable patients receiving 800 mg of megestrol acetate per day, 64.2% gained 2.27 kg (5 pounds) or more compared with 21.4% of patients receiving placebo (P < 0.001). An intent-to-treat analysis showed significant differences (P = 0.002) between those receiving placebo and those receiving 800 mg of megestrol acetate for the number of patients who gained 2.27 kg (5 pounds) or more (8 of 32 [25%] compared with 38 of 61 [62.3%], respectively). Compared with patients receiving placebo at the time of maximum weight change, evaluable patients receiving megestrol acetate, 800 mg/d, reported improvement in overall well-being and had an increase in mean weight gain (-0.725 compared with 3.54 kg [-1.6 compared with +7.8 pounds]; P < 0.001), lean body mass (-0.772 compared with +1.14 kg [-1.7 compared with +2.5 pounds]; P < 0.001), appetite grade (P < 0.001), and caloric intake (-107 compared with +645.6 calories/d; P = 0.001). In patients with AIDS-related weight loss, megestrol acetate can stimulate appetite, food intake, and statistically significant weight gain that is associated with a patient-reported improvement in an overall sense of well-being.

  8. Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance.

    PubMed

    Ding, Jun; Holzwarth, Garrett; Penner, Michael H; Patton-Vogt, Jana; Bakalinsky, Alan T

    2015-01-01

    Acetic acid-mediated inhibition of the fermentation of lignocellulose-derived sugars impedes development of plant biomass as a source of renewable ethanol. In order to overcome this inhibition, the capacity of Saccharomyces cerevisiae to synthesize acetyl-CoA from acetic acid was increased by overexpressing ACS2 encoding acetyl-coenzyme A synthetase. Overexpression of ACS2 resulted in higher resistance to acetic acid as measured by an increased growth rate and shorter lag phase relative to a wild-type control strain, suggesting that Acs2-mediated consumption of acetic acid during fermentation contributes to acetic acid detoxification. © FEMS 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Change in the plasmid copy number in acetic acid bacteria in response to growth phase and acetic acid concentration.

    PubMed

    Akasaka, Naoki; Astuti, Wiwik; Ishii, Yuri; Hidese, Ryota; Sakoda, Hisao; Fujiwara, Shinsuke

    2015-06-01

    Plasmids pGE1 (2.5 kb), pGE2 (7.2 kb), and pGE3 (5.5 kb) were isolated from Gluconacetobacter europaeus KGMA0119, and sequence analyses revealed they harbored 3, 8, and 4 genes, respectively. Plasmid copy numbers (PCNs) were determined by real-time quantitative PCR at different stages of bacterial growth. When KGMA0119 was cultured in medium containing 0.4% ethanol and 0.5% acetic acid, PCN of pGE1 increased from 7 copies/genome in the logarithmic phase to a maximum of 12 copies/genome at the beginning of the stationary phase, before decreasing to 4 copies/genome in the late stationary phase. PCNs for pGE2 and pGE3 were maintained at 1-3 copies/genome during all phases of growth. Under a higher concentration of ethanol (3.2%) the PCN for pGE1 was slightly lower in all the growth stages, and those of pGE2 and pGE3 were unchanged. In the presence of 1.0% acetic acid, PCNs were higher for pGE1 (10 copies/genome) and pGE3 (6 copies/genome) during the logarithmic phase. Numbers for pGE2 did not change, indicating that pGE1 and pGE3 increase their PCNs in response to acetic acid. Plasmids pBE2 and pBE3 were constructed by ligating linearized pGE2 and pGE3 into pBR322. Both plasmids were replicable in Escherichia coli, Acetobacter pasteurianus and G. europaeus, highlighting their suitability as vectors for acetic acid bacteria. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  10. Simultaneous measurement of neuronal and glial metabolism in rat brain in vivo using co-infusion of [1,6- 13C 2]glucose and [1,2- 13C 2]acetate

    NASA Astrophysics Data System (ADS)

    Deelchand, Dinesh K.; Nelson, Christopher; Shestov, Alexander A.; Uğurbil, Kâmil; Henry, Pierre-Gilles

    2009-02-01

    In this work the feasibility of measuring neuronal-glial metabolism in rat brain in vivo using co-infusion of [1,6- 13C 2]glucose and [1,2- 13C 2]acetate was investigated. Time courses of 13C spectra were measured in vivo while infusing both 13C-labeled substrates simultaneously. Individual 13C isotopomers (singlets and multiplets observed in 13C spectra) were quantified automatically using LCModel. The distinct 13C spectral pattern observed in glutamate and glutamine directly reflected the fact that glucose was metabolized primarily in the neuronal compartment and acetate in the glial compartment. Time courses of concentration of singly and multiply-labeled isotopomers of glutamate and glutamine were obtained with a temporal resolution of 11 min. Although dynamic metabolic modeling of these 13C isotopomer data will require further work and is not reported here, we expect that these new data will allow more precise determination of metabolic rates as is currently possible when using either glucose or acetate as the sole 13C-labeled substrate.

  11. Heterotrophic and mixotrophic growth of Micractinium pusillum Fresenius in the presence of acetate and glucose: effect of light and acetate gradient concentration.

    PubMed

    Bouarab, L; Dauta, A; Loudiki, M

    2004-06-01

    The main objective of this study was to determine the importance of secondary mechanism of organic carbon utilization (mixotrophic and heterotrophic modes) in addition to CO2 fixation (photoautotrophic mode) in the green alga, Micractinium pusillum Fresenius (chlorophyta), isolated from a waste stabilization pond. The growth was studied in the presence of acetate and glucose. The incorporation rate of 14C- acetate was measured in the light and in the dark at different concentrations. Finally, in order to underline the role of photosynthesis and respiration processes in the acetate assimilation, the effect of two specific metabolic inhibitors, a specific inhibitor of photosystem II (DCMU) and an uncoupler respiratory (DNP), has been studied. The obtained results showed that M. pusillum grows in the presence of organic substrates, i.e., glucose and acetate, in the light (mixotrophic growth) as well as in the dark (Heterotrophic growth). The growth was much more important in the light than in the dark and more in the presence of glucose than of acetate. In the light, the presence of acetate led to a variation of growth parameters mumax, iotaopt, and beta. The effect of acetate gradient on the growth of the microalga was severe as soon as its concentration in the medium was higher. The acetate uptake followed a Michaelis-Menten kinetic in the light as well as in the dark. The capacity of assimilation was slightly higher in the dark. The utilization of DNP and DCMU indicates that acetate incorporation is an active process depending on both anabolic (photosynthesis) and catabolic (respiration) metabolisms, corroborating the model of the Michaelis-Menten kinetic.

  12. 25 CFR 171.510 - How does BIA calculate my annual operation and maintenance assessment if supplemental water is...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How does BIA calculate my annual operation and maintenance assessment if supplemental water is available on the irrigation facility servicing my farm unit? 171.510 Section 171.510 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Financial...

  13. 25 CFR 171.510 - How does BIA calculate my annual operation and maintenance assessment if supplemental water is...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does BIA calculate my annual operation and maintenance assessment if supplemental water is available on the irrigation facility servicing my farm unit? 171.510 Section 171.510 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Financial...

  14. 25 CFR 171.510 - How does BIA calculate my annual operation and maintenance assessment if supplemental water is...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does BIA calculate my annual operation and maintenance assessment if supplemental water is available on the irrigation facility servicing my farm unit? 171.510 Section 171.510 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER IRRIGATION OPERATION AND MAINTENANCE Financial...

  15. 25 CFR 162.585 - How will BIA decide whether to approve a leasehold mortgage of a WSR lease?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How will BIA decide whether to approve a leasehold mortgage of a WSR lease? 162.585 Section 162.585 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leasehold Mortgages § 162.585...

  16. 25 CFR 162.585 - How will BIA decide whether to approve a leasehold mortgage of a WSR lease?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How will BIA decide whether to approve a leasehold mortgage of a WSR lease? 162.585 Section 162.585 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leasehold Mortgages § 162.585...

  17. Crystal growth, structure analysis and characterisation of 2 - (1, 3 - dioxoisoindolin - 2 - yl) acetic acid single crystal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sankari, R. Siva, E-mail: sivasankari.sh@act.edu.in; Perumal, Rajesh Narayana

    2014-04-24

    Single crystal of dielectric material 2 - (1, 3 - dioxoisoindolin - 2 - yl) acetic acid has been grown by slow evaporation solution growth method. The grown crystal was harvested in 25 days. The crystal structure was analyzed by Single crystal X - ray diffraction. UV-vis-NIR analysis was performed to examine the optical property of the grown crystal. The thermal property of the grown crystal was studied by thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The dielectric measurements were carried out and the dielectric constant was calculated and plotted at all frequencies.

  18. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.602 How will the BIA notify you or your...

  19. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.602 How will the BIA notify you or your...

  20. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.602 How will the BIA notify you or your...

  1. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.602 How will the BIA notify you or your...

  2. 25 CFR 115.602 - How will the BIA notify you or your guardian, as applicable, of its decision to restrict your IIM...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.602 How will the BIA notify you or your...

  3. Preparation of vinyl acetate

    DOEpatents

    Tustin, Gerald Charles; Zoeller, Joseph Robert; Depew, Leslie Sharon

    1998-01-01

    This invention pertains to the preparation of vinyl acetate by contacting a mixture of hydrogen and ketene with a heterogeneous catalyst containing a transition metal to produce acetaldehyde, which is then reacted with ketene in the presence of an acid catalyst to produce vinyl acetate.

  4. Preparation of vinyl acetate

    DOEpatents

    Tustin, G.C.; Zoeller, J.R.; Depew, L.S.

    1998-03-24

    This invention pertains to the preparation of vinyl acetate by contacting a mixture of hydrogen and ketene with a heterogeneous catalyst containing a transition metal to produce acetaldehyde, which is then reacted with ketene in the presence of an acid catalyst to produce vinyl acetate.

  5. Crystal structure of a mixed-ligand dinuclear Ba-Zn complex with 2-meth-oxy-ethanol having tri-phenyl-acetate and chloride bridges.

    PubMed

    Utko, Józef; Sobocińska, Maria; Dobrzyńska, Danuta; Lis, Tadeusz

    2015-07-01

    The dinuclear barium-zinc complex, μ-chlorido-1:2κ(2) Cl:Cl-chlorido-2κCl-bis-(2-meth-oxy-ethanol-1κO)bis-(2-meth-oxy-ethanol-1κ(2) O,O')bis-(μ-tri-phenyl-acetato-1:2κ(2) O:O')bariumzinc, [BaZn(C20H15O2)2Cl2(C3H8O2)4], has been synthesized by the reaction of barium tri-phenyl-acetate, anhydrous zinc chloride and 2-meth-oxy-ethanol in the presence of toluene. The barium and zinc metal cations in the dinuclear complex are linked via one chloride anion and carboxyl-ate O atoms of the tri-phenyl-acetate ligands, giving a Ba⋯Zn separation of 3.9335 (11) Å. The irregular nine-coordinate BaO8Cl coordination centres comprise eight O-atom donors, six of them from 2-meth-oxy-ethanol ligands (four from two bidentate O,O'-chelate inter-actions and two from monodentate inter-actions), two from bridging tri-phenyl-acetate ligands and one from a bridging Cl donor. The distorted tetra-hedral coordination sphere of zinc comprises two O-atom donors from the tri-phenyl-acetate ligands and two Cl donors (one bridging and one terminal). In the crystal, O-H⋯Cl, O-H⋯O and C-H⋯Cl inter-molecular inter-actions form a layered structure, lying parallel to (001).

  6. Detection of CIN by naked eye visualization after application of acetic acid.

    PubMed

    Londhe, M; George, S S; Seshadri, L

    1997-06-01

    A prospective study was undertaken to determine the sensitivity and specificity of acetic application to the cervix followed by naked eye visualization as a screening test for detection of cervical intraepithelial neoplasia. Three hundred and seventy two sexually active woman in the reproductive age group were studied. All the women underwent Papanicolaou test, acetic acid test and colposcopy. One hundred and seventy five woman were acetic acid test negative, 197 women were acetic acid test positive. The sensitivity of acetic acid test was 72.4%, specificity 54% and false negative rate 15.2%, as compared to papanicolaou test which had a sensitivity of 13.2%, specificity of 96.3% and false negative rate of 24.4%. The advantage of the acetic acid test lies in its easy technique, low cost and high sensitivity which are important factors for determining the efficacy of any screening programme in developing countries.

  7. Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).

    PubMed

    Jeon, Jeong Yong; Lee, Misu; Whang, Sang Hyun; Kim, Jung-Whan; Cho, Arthur; Yun, Mijin

    2018-01-19

    Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [18F]fluorodeoxyglucose (FDG) and [11C]acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells. In this study, we evaluated the mechanism and roles of [11C]acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of [11C]acetate uptake in HCC cell lines and human HCCs with different [11C]acetate uptake. Using two representative cell lines with widely different [11C]acetate uptake (HepG2 for high uptake and Hep3B for low uptake), changes in [11C]acetate uptake were measured after treatment with an MCT1 inhibitor or MCT1-targeted siRNA. To verify the roles of MCT1 in cells, oxygen consumption rate and the amount of lipid synthesis were measured. HepG2 cells with high [11C]acetate uptake showed higher MCT1 expression than other HCC cell lines with low [11C]acetate uptake. MCT1 expression was elevated in human HCCs with high [11C]acetate uptake compared to those with low [11C]acetate uptake. After blocking MCT1 with AR-C155858 or MCT1 knockdown, [11C]acetate uptake in HepG2 cells was significantly reduced. Additionally, inhibition of MCT1 suppressed mitochondrial oxidative phosphorylation, lipid synthesis, and cellular proliferation in HCC cells with high [11C]acetate uptake. MCT1 may be a new therapeutic target for acetate-dependent HCCs with high [11C]acetate uptake, which can be selected by [11C]acetate PET/CT imaging in clinical practice.

  8. Isotope fractionation during the anaerobic consumption of acetate by methanogenic and sulfate-reducing microorganisms

    NASA Astrophysics Data System (ADS)

    Gövert, D.; Conrad, R.

    2009-04-01

    During the anaerobic degradation of organic matter in anoxic sediments and soils acetate is the most important substrate for the final step in production of CO2 and/or CH4. Sulfate-reducing bacteria (SRB) and methane-producing archaea both compete for the available acetate. Knowledge about the fractionation of 13C/12C of acetate carbon by these microbial groups is still limited. Therefore, we determined carbon isotope fractionation in different cultures of acetate-utilizing SRB (Desulfobacter postgatei, D. hydrogenophilus, Desulfobacca acetoxidans) and methanogens (Methanosarcina barkeri, M. acetivorans). Including literature values (e.g., Methanosaeta concilii), isotopic enrichment factors (epsilon) ranged between -35 and +2 permil, possibly involving equilibrium isotope effects besides kinetic isotope effects. The values of epsilon were dependent on the acetate-catabolic pathway of the particular microorganism, the methyl or carboxyl position of acetate, and the relative availability or limitation of the substrate acetate. Patterns of isotope fractionation in anoxic lake sediments and rice field soil seem to reflect the characteristics of the microorganisms actively involved in acetate catabolism. Hence, it might be possible using environmental isotopic information to determine the type of microbial metabolism converting acetate to CO2 and/or CH4.

  9. Platinum(II) acetate complexes in hydrogenation of unsaturated compounds

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berenblyum, A.S.; Goranskaya, T.P.; Mund, S.L.

    1979-12-20

    In order to further elucidate the effect of the ligand environment in the complexes of group VIII metals on the activity of H/sub 2/, the catalytic properties of Pt(II) compounds with oxygen-containing acido ligands was studied. The platinum(II) acetate complexes with aniline and triphenylphosphine were synthesized. IR spectral studies indicated that platinum(II) acetate formed complexes with either of the other compounds singly or together. Dimethylformamide(DMF) solutions of platinum acetate and its complexes with aniline and/or triphenylphosphine all absorb H/sub 2/ in the temperature range of 20 to 90/sup 0/C and at a H/sub 2/ pressure of 1 atm. After themore » absorption of H/sub 2/, the DMF solutions of (aniline)(triphenylphosphine)platinum(II)diacetate complex were found to catalyze the hydrogenaton of O/sub 2/ and 1,3-pentadiene.« less

  10. Improvement of nutritional status as assessed by multifrequency BIA during 15 weeks of refeeding in adolescent girls with anorexia nervosa.

    PubMed

    Mika, Claudia; Herpertz-Dahlmann, Beate; Heer, Martina; Holtkamp, Kristian

    2004-11-01

    In patients with anorexia nervosa (AN), an assessment of changes in body composition and nutritional status is crucial for adequate nutritional management during refeeding therapies. Phase-sensitive multifrequency bioelectrical impedance analysis (BIA) is an inexpensive and noninvasive technique with which to determine nutritional status and body composition. We investigated 21 female adolescents with AN (initial BMI 15.5 +/- 1.1 kg/m(2)) 4 times between wk 3 and 15 of inpatient refeeding and 19 normal-weight, age-matched female controls. From wk 3 to 15, BMI, fat mass, body cell mass (BCM), total body water (TBW), intracellular water (ICW) but not extracellular mass (ECM), and extracellular water (ECW) increased significantly. Reactance (Xc), phase angle (PhA), and the ECM/BCM index as parameters of nutritional status improved significantly in patients and no longer differed from controls in wk 15, although the BMI of patients was significantly lower than those of controls. Changes in the ECM/BCM index were due to accretion of BCM, which was associated with an increase of ICW. Multifrequency phase-sensitive BIA seems to be a promising tool for the assessment of changes in nutritional status and body composition in patients with AN. An individually determined and controlled hyperenergetic diet as part of a multidimensional, interdisciplinary treatment program for eating disorders seems to quickly improve the nutritional status of AN patients.

  11. 25 CFR 115.600 - If BIA decides to restrict your IIM account under § 115.102 or § 115.104, what procedures must...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.600 If BIA decides to restrict...

  12. 25 CFR 115.600 - If BIA decides to restrict your IIM account under § 115.102 or § 115.104, what procedures must...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.600 If BIA decides to restrict...

  13. 25 CFR 115.600 - If BIA decides to restrict your IIM account under § 115.102 or § 115.104, what procedures must...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.600 If BIA decides to restrict...

  14. 25 CFR 115.600 - If BIA decides to restrict your IIM account under § 115.102 or § 115.104, what procedures must...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.600 If BIA decides to restrict...

  15. 25 CFR 115.600 - If BIA decides to restrict your IIM account under § 115.102 or § 115.104, what procedures must...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM Account § 115.600 If BIA decides to restrict...

  16. Synthesis of Highly Polymerized Water-soluble Cellulose Acetate by the Side Reaction in Carboxylate Ionic Liquid 1-ethyl-3-methylimidazolium Acetate

    NASA Astrophysics Data System (ADS)

    Pang, Jinhui; Liu, Xin; Yang, Jun; Lu, Fachuang; Wang, Bo; Xu, Feng; Ma, Mingguo; Zhang, Xueming

    2016-09-01

    In the present study, we describe a novel one-step method to prepare water-soluble cellulose acetate (WSCA) with higher degree of polymerization values (DP = 650-680) by in situ activation of carboxyl group in ionic liquid. First of all, cellulose was dissolved in 1-ethyl-3-methylimidazolium acetate (EmimAc) and reacted with dichloroacetyl chloride (Cl2AcCl) in order to make cellulose dichloroacetate. Under various conditions, a series of water soluble products were produced. Elemental analysis and NMR results confirmed that they were cellulose acetate with DS (degree of substitution) values in the range from 0.30 to 0.63. NMR studies demonstrated that Cl2AcCl reacted with acetate anion of EmimAc producing a mixed anhydride that acetylated cellulose. Other acylating reagents such as benzoyl chloride, chloroacetyl chloride can also work similarly. 2D NMR characterization suggested that 6-mono-O-acetyl moiety, 3,6-di-O-acetylcellulose and 2,6-di-O-acetyl cellulose were all synthesized and the reactivity of hydroxyl groups in anhydro-glucose units was in the order C-6>C-3>C-2. This work provides an alternative way to make WSCA, meanwhile, also services as a reminder that the activity of EmimAc toward carbohydrate as acylating reagents could be a problem, because the expected acylated products may not be resulted and recycling of this ionic liquid could also be difficult.

  17. Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses

    PubMed Central

    Jayakody, Kaushadh; Gibson, Roger Carl; Kumar, Ajit; Gunadasa, Shalmini

    2014-01-01

    Background Medication used for acute aggression in psychiatry must have rapid onset of effect, low frequency of administration and low levels of adverse effects. Zuclopenthixol acetate is said to have these properties. Objectives To estimate the clinical effects of zuclopenthixol acetate for the management of acute aggression or violence thought to be due to serious mental illnesses, in comparison to other drugs used to treat similar conditions. Search methods We searched the Cochrane Schizophrenia’s Group Trials Register (July 2011). We supplemented this by citation searching and personal contact with authors and relevant pharmaceutical companies. Selection criteria All randomised clinical trials involving people thought to have serious mental illnesses comparing zuclopenthixol acetate with other drugs. Data collection and analysis Two review authors extracted and cross-checked data independently. We calculated fixed-effect relative risks (RR) and 95% confidence intervals (CI) for dichotomous data. We analysed by intention-to-treat. We used mean differences (MD) for continuous variables. Main results We found no data for the primary outcome, tranquillisation. Compared with haloperidol, zuclopenthixol acetate was no more sedating at two hours (n = 40, 1 RCT, RR 0.60, 95% CI 0.27 to 1.34). People given zuclopenthixol acetate were not at reduced risk of being given supplementary antipsychotics (n = 134, 3 RCTs, RR 1.49, 95% CI 0.97 to 2.30) although additional use of benzodiazepines was less (n = 50, 1 RCT, RR 0.03, 95% CI 0.00 to 0.47). People given zuclopenthixol acetate had fewer injections over seven days compared with those allocated to haloperidol IM (n = 70, 1 RCT, RR 0.39, 95% CI 0.18 to 0.84, NNT 4, CI 3 to 14). We found no data on more episodes of aggression or harm to self or others. One trial (n = 148) reported no significant difference in adverse effects for people receiving zuclopenthixol acetate compared with those allocated haloperidol at one, three

  18. Biotechnological applications of acetic acid bacteria.

    PubMed

    Raspor, Peter; Goranovic, Dusan

    2008-01-01

    products of biotransformations by AAB or their enzymes include 2-keto-L-gulonic acid, which is used for the production of vitamin C; D-tagatose, which is used as a bulking agent in food and a noncalorific sweetener; and shikimate, which is a key intermediate for a large number of antibiotics. Recently, for the first time, a pathogenic acetic acid bacterium was described, representing the newest and tenth genus of AAB.

  19. Microbial Electrosynthesis and Anaerobic Fermentation: An Economic Evaluation for Acetic Acid Production from CO2 and CO.

    PubMed

    Christodoulou, Xenia; Velasquez-Orta, Sharon B

    2016-10-18

    Microbial electrosynthesis (MES) and anaerobic fermentation (AF) are two biological processes capable of reducing CO 2 , CO, and water into acetic acid, an essential industrial reagent. In this study, we evaluated investment and production costs of acetic acid via MES and AF, and compared them to industrial chemical processes: methanol carbonylation and ethane direct oxidation. Production and investment costs were found high-priced for MES (1.44 £/kg, 1770 £/t) and AF (4.14 £/kg, 1598 £/t) because of variable and fixed costs and low production yields (100 t/y) compared to methanol carbonylation (0.26 £/kg, 261 £/t) and ethane direct oxidation (0.11 £/kg, 258 £/t). However, integrating AF with MES would reduce the release of CO 2 , double production rates (200 t/y), and decrease investment costs by 9% (1366 £/t). This resulted into setting the production costs at 0.24 £/kg which is currently market competitive (0.48 £/kg). This economically feasible bioprocess produced molar flow rates of 4550 mol per day from MES and AF independently. Our findings offer a bright opportunity toward the use and scale-up of MES and AF for an economically viable acetic acid production process.

  20. Understanding chemical reactions of CO2 and its isoelectronic molecules with 1-butyl-3-methylimidazolium acetate by changing the nature of the cation: the case of CS2 in 1-butyl-1-methylpyrrolidinium acetate studied by NMR spectroscopy and density functional theory calculations.

    PubMed

    Cabaço, M Isabel; Besnard, Marcel; Chávez, Fabián Vaca; Pinaud, Noël; Sebastião, Pedro J; Coutinho, João A P; Danten, Yann

    2014-06-28

    NMR spectroscopy ((1)H, (13)C, (15)N) shows that carbon disulfide reacts spontaneously with 1-butyl-1-methylpyrrolidinium acetate ([BmPyrro][Ac]) in the liquid phase. It is found that the acetate anions play an important role in conditioning chemical reactions with CS2 leading, via coupled complex reactions, to the degradation of this molecule to form thioacetate anion (CH3COS(-)), CO2, OCS, and trithiocarbonate (CS3 (2-)). In marked contrast, the cation does not lead to the formation of any adducts allowing to conclude that, at most, its role consists in assisting indirectly these reactions. The choice of the [BmPyrro](+) cation in the present study allows disentangling the role of the anion and the cation in the reactions. As a consequence, the ensemble of results already reported on CS2-[Bmim][Ac] (1), OCS-[Bmim][Ac] (2), and CO2-[Bmim][Ac] (3) systems can be consistently rationalized. It is argued that in system (1) both anion and cation play a role. The CS2 reacts with the acetate anion leading to the formation of CH3COS(-), CO2, and OCS. After these reactions have proceeded the nascent CO2 and OCS interact with the cation to form imidazolium-carboxylate ([Bmim] CO2) and imidazolium-thiocarboxylate ([Bmim] COS). The same scenario also applies to system (2). In contrast, in the CO2-[Bmim] [Ac] system a concerted cooperative process between the cation, the anion, and the CO2 molecule takes place. A carbene issued from the cation reacts to form the [Bmim] CO2, whereas the proton released by the ring interacts with the anion to produce acetic acid. In all these systems, the formation of adduct resulting from the reaction between the solute molecule and the carbene species originating from the cation is expected. However, this species was only observed in systems (2) and (3). The absence of such an adduct in system (1) has been theoretically investigated using DFT calculations. The values of the energetic barrier of the reactions show that the formation of [Bmim

  1. 25 CFR 162.529 - Will BIA review a proposed WEEL before or during preparation of the NEPA review documentation?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Will BIA review a proposed WEEL before or during preparation of the NEPA review documentation? 162.529 Section 162.529 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Approval...

  2. 25 CFR 162.529 - Will BIA review a proposed WEEL before or during preparation of the NEPA review documentation?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Will BIA review a proposed WEEL before or during preparation of the NEPA review documentation? 162.529 Section 162.529 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES AND PERMITS Wind and Solar Resource Leases Weel Approval...

  3. Energy Efficiency and Productivity Enhancement of Microbial Electrosynthesis of Acetate

    PubMed Central

    LaBelle, Edward V.; May, Harold D.

    2017-01-01

    It was hypothesized that a lack of acetogenic biomass (biocatalyst) at the cathode of a microbial electrosynthesis system, due to electron and nutrient limitations, has prevented further improvement in acetate productivity and efficiency. In order to increase the biomass at the cathode and thereby performance, a bioelectrochemical system with this acetogenic community was operated under galvanostatic control and continuous media flow through a reticulated vitreous carbon (RVC) foam cathode. The combination of galvanostatic control and the high surface area cathode reduced the electron limitation and the continuous flow overcame the nutrient limitation while avoiding the accumulation of products and potential inhibitors. These conditions were set with the intention of operating the biocathode through the production of H2. Biofilm growth occurred on and within the unmodified RVC foam regardless of vigorous H2 generation on the cathode surface. A maximum volumetric rate or space time yield for acetate production of 0.78 g/Lcatholyte/h was achieved with 8 A/Lcatholyte (83.3 A/m2projected surface area of cathode) supplied to the continuous flow/culture bioelectrochemical reactors. The total Coulombic efficiency in H2 and acetate ranged from approximately 80–100%, with a maximum of 35% in acetate. The overall energy efficiency ranged from approximately 35–42% with a maximum to acetate of 12%. PMID:28515713

  4. Energy Efficiency and Productivity Enhancement of Microbial Electrosynthesis of Acetate.

    PubMed

    LaBelle, Edward V; May, Harold D

    2017-01-01

    It was hypothesized that a lack of acetogenic biomass (biocatalyst) at the cathode of a microbial electrosynthesis system, due to electron and nutrient limitations, has prevented further improvement in acetate productivity and efficiency. In order to increase the biomass at the cathode and thereby performance, a bioelectrochemical system with this acetogenic community was operated under galvanostatic control and continuous media flow through a reticulated vitreous carbon (RVC) foam cathode. The combination of galvanostatic control and the high surface area cathode reduced the electron limitation and the continuous flow overcame the nutrient limitation while avoiding the accumulation of products and potential inhibitors. These conditions were set with the intention of operating the biocathode through the production of H 2 . Biofilm growth occurred on and within the unmodified RVC foam regardless of vigorous H 2 generation on the cathode surface. A maximum volumetric rate or space time yield for acetate production of 0.78 g/L catholyte /h was achieved with 8 A/L catholyte (83.3 A/m 2 projected surface area of cathode) supplied to the continuous flow/culture bioelectrochemical reactors. The total Coulombic efficiency in H 2 and acetate ranged from approximately 80-100%, with a maximum of 35% in acetate. The overall energy efficiency ranged from approximately 35-42% with a maximum to acetate of 12%.

  5. Mixture Toxicity of SN2-Reactive Soft Electrophiles: 2—Evaluation of Mixtures Containing Ethyl α-Halogenated Acetates

    PubMed Central

    Mooneyham, T.; Jeyaratnam, J.; Schultz, T. W.; Pöch, G.

    2011-01-01

    Four ethyl α-halogenated acetates were tested in (1) sham and (2) nonsham combinations and (3) with a nonreactive nonpolar narcotic. Ethyl iodoacetate (EIAC), ethyl bromoacetate (EBAC), ethyl chloroacetate (ECAC), and ethyl fluoroacetate (EFAC), each considered to be an SN2-H-polar soft electrophile, were selected for testing based on their differences in electro(nucleo)philic reactivity and time-dependent toxicity (TDT). Agent reactivity was assessed using the model nucleophile glutathione, with EIAC and EBAC showing rapid reactivity, ECAC being less reactive, and EFAC lacking reactivity at ≤250 mM. The model nonpolar narcotic, 3-methyl-2-butanone (3M2B), was not reactive. Toxicity of the agents alone and in mixture was assessed using the Microtox acute toxicity test at three exposure durations: 15, 30 and 45 min. Two of the agents alone (EIAC and EBAC) had TDT values >100%. In contrast, ECAC (74 to 99%) and EFAC (9 to 12%) had partial TDT, whereas 3M2B completely lacked TDT (<0%). In mixture testing, sham combinations of each agent showed a combined effect consistent with predicted effects for dose-addition at each time point, as judged by EC50 dose-addition quotient values. Mixture toxicity results for nonsham ethyl acetate combinations were variable, with some mixtures being inconsistent with the predicted effects for dose-addition and/or independence. The ethyl acetate–3M2B combinations were somewhat more toxic than predicted for dose-addition, a finding differing from that observed previously for α-halogenated acetonitriles with 3M2B. PMID:21452006

  6. Ulipristal acetate versus placebo for fibroid treatment before surgery.

    PubMed

    Donnez, Jacques; Tatarchuk, Tetyana F; Bouchard, Philippe; Puscasiu, Lucian; Zakharenko, Nataliya F; Ivanova, Tatiana; Ugocsai, Gyula; Mara, Michal; Jilla, Manju P; Bestel, Elke; Terrill, Paul; Osterloh, Ian; Loumaye, Ernest

    2012-02-02

    The efficacy and safety of oral ulipristal acetate for the treatment of symptomatic uterine fibroids before surgery are uncertain. We randomly assigned women with symptomatic fibroids, excessive uterine bleeding (a score of >100 on the pictorial blood-loss assessment chart [PBAC, an objective assessment of blood loss, in which monthly scores range from 0 to >500, with higher numbers indicating more bleeding]) and anemia (hemoglobin level of ≤10.2 g per deciliter) to receive treatment for up to 13 weeks with oral ulipristal acetate at a dose of 5 mg per day (96 women) or 10 mg per day (98 women) or to receive placebo (48 women). All patients received iron supplementation. The coprimary efficacy end points were control of uterine bleeding (PBAC score of <75) and reduction of fibroid volume at week 13, after which patients could undergo surgery. At 13 weeks, uterine bleeding was controlled in 91% of the women receiving 5 mg of ulipristal acetate, 92% of those receiving 10 mg of ulipristal acetate, and 19% of those receiving placebo (P<0.001 for the comparison of each dose of ulipristal acetate with placebo). The rates of amenorrhea were 73%, 82%, and 6%, respectively, with amenorrhea occurring within 10 days in the majority of patients receiving ulipristal acetate. The median changes in total fibroid volume were -21%, -12%, and +3% (P=0.002 for the comparison of 5 mg of ulipristal acetate with placebo, and P=0.006 for the comparison of 10 mg of ulipristal acetate with placebo). Ulipristal acetate induced benign histologic endometrial changes that had resolved by 6 months after the end of therapy. Serious adverse events occurred in one patient during treatment with 10 mg of ulipristal acetate (uterine hemorrhage) and in one patient during receipt of placebo (fibroid protruding through the cervix). Headache and breast tenderness were the most common adverse events associated with ulipristal acetate but did not occur significantly more frequently than with placebo

  7. Optimisation of continuous gas fermentation by immobilisation of acetate-producing Acetobacterium woodii.

    PubMed

    Steger, Franziska; Rachbauer, Lydia; Windhagauer, Matthias; Montgomery, Lucy F R; Bochmann, Günther

    2017-08-01

    Hydrogen from water electrolysis is often suggested as a way of storing the excess energy from wind and solar power plants. However, unlike natural gas, hydrogen is difficult to store and distribute. One solution is to convert the hydrogen into other fuels or bulk chemicals. In this study we investigated fermentation in which homoacetogenic clostridia apply the Wood-Ljungdahl pathway to generate acetate from H 2 and CO 2 . Acetate can be used as a bulk chemical or further transformed into biofuels. Autotrophic growth with CO 2 as the sole carbon source is slow compared to heterotrophic growth, so the aim of this work was to improve continuous gas fermentation by immobilising the acetate-producing clostridia, thus preventing their wash out from the bioreactor. Two homoacetogenic bacterial strains (Acetobacterium woodii and Moorella thermoacetica) were tested for their acetate production potential, with A. woodii proving to be the better strain with maximum acetate concentration of 29.57 g l -1 . Due to its stability during fermentation and good bacterial immobilisation, linen was chosen as immobilisation material for continuous fermentation. This study demonstrates the successful continuous fermentation of acetate from H 2 and CO 2 using A. woodii immobilised on a low-cost surface at high volumetric productivity of 1.21 ± 0.05 g acetate l -1 d -1 . This has great industrial potential and future studies should focus on the scale-up of this process. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Acetate Dose-Dependently Stimulates Milk Fat Synthesis in Lactating Dairy Cows.

    PubMed

    Urrutia, Natalie L; Harvatine, Kevin J

    2017-05-01

    Background: Acetate is a short-chain fatty acid (FA) that is especially important to cows because it is the major substrate for de novo FA synthesis. However, the effect of acetate supply on mammary lipid synthesis is not clear. Objective: The objective of this experiment was to determine the effect of increasing acetate supply on milk fat synthesis in lactating dairy cows. Methods: Six multiparous lactating Holstein cows were randomly assigned to treatments in a replicated design to investigate the effect of acetate supply on milk fat synthesis. Treatments were 0 (control), 5, 10, and 15 mol acetate/d continuously infused into the rumen for 4 d. Rumen short-chain FAs, plasma hormones and metabolites, milk fat concentration, and milk FA profile were analyzed on day 4 of each treatment. Polynomial contrasts were used to test the linear and quadratic effects of increasing acetate supply. Results: Acetate increased milk fat yield quadratically ( P < 0.01) by 7%, 16%, and 14% and increased milk fat concentration linearly ( P < 0.001) by 6%, 9%, and 11% for 5, 10, and 15 mol acetate/d, respectively, compared with the control treatment. Increased milk fat yield predominantly was due to a linear increase in 16-carbon FAs ( P < 0.001) and a quadratic increase in de novo synthesized FAs (<16-carbon FAs; P < 0.01), indicating that there was stimulation of de novo synthesis pathways. Apparent transfer of acetate to milk fat was 33.4%, 36.2%, and 20.6% for 5, 10, and 15 mol/d, respectively. Acetate infusion linearly increased the relative concentration of rumen acetate ( P < 0.001) before feeding, but not after feeding. Acetate linearly increased plasma ß-hydroxybutyric acid by 29%, 50%, and 78%, respectively, after feeding compared with the control treatment ( P < 0.01). Conclusions: Increasing acetate supply to lactating cows increases milk fat synthesis, suggesting that nutritional strategies that increase ruminal acetate absorption would be expected to increase milk fat

  9. Performance of dairy cows fed high levels of acetic acid or ethanol.

    PubMed

    Daniel, J L P; Amaral, R C; Sá Neto, A; Cabezas-Garcia, E H; Bispo, A W; Zopollatto, M; Cardoso, T L; Spoto, M H F; Santos, F A P; Nussio, L G

    2013-01-01

    Ethanol and acetic acid are common end products from silages. The main objective of this study was to determine whether high concentrations of ethanol or acetic acid in total mixed ration would affect performance in dairy cows. Thirty mid-lactation Holstein cows were grouped in 10 blocks and fed one of the following diets for 7 wk: (1) control (33% Bermuda hay + 67% concentrates), (2) ethanol [control diet + 5% ethanol, dry matter (DM) basis], or (3) acetic acid (control diet + 5% acetic acid, DM basis). Ethanol and acetic acid were diluted in water (1:2) and sprayed onto total mixed rations twice daily before feeding. An equal amount of water was mixed with the control ration. To adapt animals to these treatments, cows were fed only half of the treatment dose during the first week of study. Cows fed ethanol yielded more milk (37.9 kg/d) than those fed the control (35.8 kg/d) or acetic acid (35.3 kg/d) diets, mainly due to the higher DM intake (DMI; 23.7, 22.2, and 21.6 kg/d, respectively). The significant diet × week interaction for DMI, mainly during wk 2 and 3 (when acetic acid reached the full dose), was related to the decrease in DMI observed for the acetic acid treatment. There was a diet × week interaction in excretion of milk energy per DMI during wk 2 and 3, due to cows fed acetic acid sustained milk yield despite lower DMI. Energy efficiency was similar across diets. Blood metabolites (glucose, insulin, nonesterified fatty acids, ethanol, and γ-glutamyl transferase activity) and sensory characteristics of milk were not affected by these treatments. Animal performance suggested similar energy value for the diet containing ethanol compared with other diets. Rumen conversion of ethanol to acetate and a concomitant increase in methane production might be a plausible explanation for the deviation of the predicted energy value based on the heat of combustion. Therefore, the loss of volatile compounds during the drying process in the laboratory should be

  10. 21 CFR 582.6185 - Calcium acetate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Calcium acetate. 582.6185 Section 582.6185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Calcium acetate. (a) Product. Calcium acetate. (b) Conditions of use. This substance is generally...

  11. 21 CFR 582.6185 - Calcium acetate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Calcium acetate. 582.6185 Section 582.6185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Calcium acetate. (a) Product. Calcium acetate. (b) Conditions of use. This substance is generally...

  12. 21 CFR 582.6185 - Calcium acetate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Calcium acetate. 582.6185 Section 582.6185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Calcium acetate. (a) Product. Calcium acetate. (b) Conditions of use. This substance is generally...

  13. 21 CFR 582.6185 - Calcium acetate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Calcium acetate. 582.6185 Section 582.6185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Calcium acetate. (a) Product. Calcium acetate. (b) Conditions of use. This substance is generally...

  14. 21 CFR 582.6185 - Calcium acetate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Calcium acetate. 582.6185 Section 582.6185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Calcium acetate. (a) Product. Calcium acetate. (b) Conditions of use. This substance is generally...

  15. Acetic acid in aged vinegar affects molecular targets for thrombus disease management.

    PubMed

    Jing, Li; Yanyan, Zhang; Junfeng, Fan

    2015-08-01

    To elucidate the mechanism underlying the action of dietary vinegar on antithrombotic activity, acetic acid, the main acidic component of dietary vinegar, was used to determine antiplatelet and fibrinolytic activity. The results revealed that acetic acid significantly inhibits adenosine diphosphate (ADP)-, collagen-, thrombin-, and arachidonic acid (AA)-induced platelet aggregation. Acetic acid (2.00 mM) reduced AA-induced platelet aggregation to approximately 36.82 ± 1.31%, and vinegar (0.12 mL L(-1)) reduced the platelet aggregation induced by AA to 30.25 ± 1.34%. Further studies revealed that acetic acid exerts its effects by inhibiting cyclooxygenase-1 and the formation of thromboxane-A2. Organic acids including acetic acid, formic acid, lactic acid, citric acid, and malic acid also showed fibrinolytic activity; specifically, the fibrinolytic activity of acetic acid amounted to 1.866 IU urokinase per mL. Acetic acid exerted its fibrinolytic activity by activating plasminogen during fibrin crossing, thus leading to crosslinked fibrin degradation by the activated plasmin. These results suggest that organic acids in dietary vinegar play important roles in the prevention and cure of cardiovascular diseases.

  16. Thermal decarboxylation of acetic acid: Implications for origin of natural gas

    USGS Publications Warehouse

    Kharaka, Y.K.; Carothers, W.W.; Rosenbauer, R.J.

    1983-01-01

    Laboratory experiments on the thermal decarboxylation of solutions of acetic acid at 200??C and 300??C were carried out in hydrothermal equipment allowing for on-line sampling of both the gas and liquid phases for chemical and stable-carbon-isotope analyses. The solutions had ambient pH values between 2.5 and 7.1; pH values and the concentrations of the various acetate species at the conditions of the experiments were computed using a chemical model. Results show that the concentrations of acetic acid, and not total acetate in solution, control the reaction rates which follow a first order equation based on decreasing concentrations of acetic acid with time. The decarboxylation rates at 200??C (1.81 ?? 10-8 per second) and 300??C (8.17 ?? 10-8 per second) and the extrapolated rates at lower temperatures are relatively high. The activation energy of decarboxylation is only 8.1 kcal/mole. These high decarboxylation rates, together with the distribution of short-chained aliphatic acid anions in formation waters, support the hypothesis that acid anions are precursors for an important portion of natural gas. Results of the ??13C values of CO2, CH4, and total acetate show a reasonably constant fractionation factor of about 20 permil between CO2 and CH4 at 300??C. The ??13C values of CO2 and CH4 are initially low and become higher as decarboxylation increases. ?? 1983.

  17. 21 CFR 582.1721 - Sodium acetate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Sodium acetate. 582.1721 Section 582.1721 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS....1721 Sodium acetate. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally...

  18. 21 CFR 582.1721 - Sodium acetate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Sodium acetate. 582.1721 Section 582.1721 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS....1721 Sodium acetate. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally...

  19. 21 CFR 582.1721 - Sodium acetate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Sodium acetate. 582.1721 Section 582.1721 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS....1721 Sodium acetate. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally...

  20. 21 CFR 582.1721 - Sodium acetate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Sodium acetate. 582.1721 Section 582.1721 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS....1721 Sodium acetate. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally...

  1. 21 CFR 582.1721 - Sodium acetate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Sodium acetate. 582.1721 Section 582.1721 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS....1721 Sodium acetate. (a) Product. Sodium acetate. (b) Conditions of use. This substance is generally...

  2. Synthesis, structural characterization and DNA interaction of zinc complex from 2,6-diacetylpyridine dihydrazone and {4-[(2E)-2-(hydroxyimino)acetyl]phenoxy} acetic acid.

    PubMed

    Gup, Ramazan; Gökçe, Cansu; Dilek, Nefise

    2015-03-01

    A new water soluble zinc complex has been prepared and structurally characterized. The Zn(II) complex was synthesized by the reaction of 2,6-diacetylpyridine dihydrazone (dph) with {4-[(2E)-2-(hydroxyimino)acetyl]phenoxy} acetic acid (H₂L) in the presence of zinc(II) acetate. Single crystal X-ray diffraction study revealed that the zinc ion is situated in distorted trigonal-bipyramidal environment where the equatorial position is occupied by the nitrogen atom of pyridine ring and the oxygen atoms of acetate groups of two oxime ligands (H₂L) whereas the axial positions of the zinc complex are occupied by the imine nitrogen atoms of dph ligand. Characterization of the complex with FTIR, (1)H and (13)C NMR, UV-vis and elemental analysis also confirmed the proposed structure. Interaction of the Zn(II) complex with calf-thymus DNA (CT-DNA) was investigated through UV-vis spectroscopy and viscosity measurements. The results suggest that the complex preferably bind to DNA through the groove binding mode. The zinc complex cleaves plasmid pBR 322 DNA in the presence and absence of an oxidative agent (H₂O₂), possibly through a hydrolytic pathway which is also supported by DNA cleave experiments in the presence of different radical scavengers. The nuclease activity of the zinc complex significantly depends on concentration of the complex and incubation time both in the presence and absence of H₂O₂. DNA cleave activity is inhibited in the presence of methyl green indicating that the zinc complex seems to bind the major groove of DNA. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Simultaneous production of acetic and gluconic acids by a thermotolerant Acetobacter strain during acetous fermentation in a bioreactor.

    PubMed

    Mounir, Majid; Shafiei, Rasoul; Zarmehrkhorshid, Raziyeh; Hamouda, Allal; Ismaili Alaoui, Mustapha; Thonart, Philippe

    2016-02-01

    The activity of bacterial strains significantly influences the quality and the taste of vinegar. Previous studies of acetic acid bacteria have primarily focused on the ability of bacterial strains to produce high amounts of acetic acid. However, few studies have examined the production of gluconic acid during acetous fermentation at high temperatures. The production of vinegar at high temperatures by two strains of acetic acid bacteria isolated from apple and cactus fruits, namely AF01 and CV01, respectively, was evaluated in this study. The simultaneous production of gluconic and acetic acids was also examined in this study. Biochemical and molecular identification based on a 16s rDNA sequence analysis confirmed that these strains can be classified as Acetobacter pasteurianus. To assess the ability of the isolated strains to grow and produce acetic acid and gluconic acid at high temperatures, a semi-continuous fermentation was performed in a 20-L bioreactor. The two strains abundantly grew at a high temperature (41°C). At the end of the fermentation, the AF01 and CV01 strains yielded acetic acid concentrations of 7.64% (w/v) and 10.08% (w/v), respectively. Interestingly, CV01 was able to simultaneously produce acetic and gluconic acids during acetic fermentation, whereas AF01 mainly produced acetic acid. In addition, CV01 was less sensitive to ethanol depletion during semi-continuous fermentation. Finally, the enzymatic study showed that the two strains exhibited high ADH and ALDH enzyme activity at 38°C compared with the mesophilic reference strain LMG 1632, which was significantly susceptible to thermal inactivation. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  4. 40 CFR 86.093-2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... a passenger-carrying vehicle powered by a heavy heavy-duty diesel engine, or of a type normally powered by a heavy heavy-duty diesel engine, with a load capacity of fifteen or more passengers and... urban buses is the same as the useful life for other heavy heavy-duty diesel engines. [58 FR 15795, Mar...

  5. 40 CFR 86.093-2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a passenger-carrying vehicle powered by a heavy heavy-duty diesel engine, or of a type normally powered by a heavy heavy-duty diesel engine, with a load capacity of fifteen or more passengers and... urban buses is the same as the useful life for other heavy heavy-duty diesel engines. [58 FR 15795, Mar...

  6. 40 CFR 86.093-2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a passenger-carrying vehicle powered by a heavy heavy-duty diesel engine, or of a type normally powered by a heavy heavy-duty diesel engine, with a load capacity of fifteen or more passengers and... urban buses is the same as the useful life for other heavy heavy-duty diesel engines. [58 FR 15795, Mar...

  7. 25 CFR 1000.72 - Will OSG notify Tribes/Consortia and affected non-BIA bureaus of the results of the selection...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... bureaus of the results of the selection process? 1000.72 Section 1000.72 Indians OFFICE OF THE ASSISTANT...-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.72 Will OSG...

  8. 25 CFR 1000.72 - Will OSG notify Tribes/Consortia and affected non-BIA bureaus of the results of the selection...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... bureaus of the results of the selection process? 1000.72 Section 1000.72 Indians OFFICE OF THE ASSISTANT...-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.72 Will OSG...

  9. 25 CFR 1000.72 - Will OSG notify Tribes/Consortia and affected non-BIA bureaus of the results of the selection...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... bureaus of the results of the selection process? 1000.72 Section 1000.72 Indians OFFICE OF THE ASSISTANT...-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.72 Will OSG...

  10. 25 CFR 1000.72 - Will OSG notify Tribes/Consortia and affected non-BIA bureaus of the results of the selection...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... bureaus of the results of the selection process? 1000.72 Section 1000.72 Indians OFFICE OF THE ASSISTANT...-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other Financial Assistance for Planning and Negotiation Grants for Non-BIA Programs Eligibility and Application Process § 1000.72 Will OSG...

  11. Methane production from bicarbonate and acetate in an anoxic marine sediment

    NASA Technical Reports Server (NTRS)

    Crill, P. M.; Martens, C. S.

    1986-01-01

    Methane production from C-14 labeled bicarbonate and acetate was measured over the top 28 cm of anoxic Cape Lookout Bight sediments during the summer of 1983. The depth distribution and magnitude of summed radioisotopically determined rates compare well with previous measurements of total methane production and the sediment-water methane flux. Methane production from CO2 reduction and acetate fermentation accounts for greater than 80 percent of the total production rate and sediment-water flux. Methane production from bicarbonate was found to occur in all depth intervals sampled except those in the top 2 cm, whereas significant methane production from acetate only occurred at depths below 10 cm where sulfate was exhausted. Acetate provided 20 to 29 percent of the measured methane production integrated over the top 30 cm of the sediments.

  12. Microbial reduction of Fe(III) and turnover of acetate in Hawaiian soils.

    PubMed

    Küsel, Kirsten; Wagner, Christine; Trinkwalter, Tanja; Gössner, Anita S; Bäumler, Rupert; Drake, Harold L

    2002-04-01

    Soils contain anoxic microzones, and acetate is an intermediate during the turnover of soil organic carbon. Due to negligible methanogenic activities in well-drained soils, acetate accumulates under experimentally imposed short-term anoxic conditions. In contrast to forest, agricultural, and prairie soils, grassland soils from Hawaii rapidly consumed rather than formed acetate when incubated under anoxic conditions. Thus, alternative electron acceptors that might be linked to the anaerobic oxidation of soil organic carbon in Hawaiian soils were assessed. Under anoxic conditions, high amounts of Fe(II) were formed by Hawaiian soils as soon as soils were depleted of nitrate. Rates of Fe(II) formation for different soils ranged from 0.01 to 0.31 micromol (g dry weight soil)(-1) h(-1), but were not positively correlated to increasing amounts of poorly crystallized iron oxides. In general, sulfate-reducing and methanogenic activities were negligible. Supplemental acetate was rapidly oxidized to CO2 via the sequential reduction of nitrate and Fe(III) in grassland soil (obtained near Kaena State Park). Supplemental H2 stimulated the formation of Fe(II), but H2-utilizing acetogens appeared to also be involved in the consumption of H2. Approximately 270 micromol Fe(III) (g dry weight soil)(-1) was available for Fe(III)-reducing bacteria, and acetate became a stable end product when Fe(III) was depleted in long-term incubations. Most-probable-number estimates of H2- and acetate-utilizing Fe(III) reducers and of H2-utilizing acetogens were similar. These results indicate that (i) the microbial reduction of Fe(III) is an important electron-accepting process for the anaerobic oxidation of organic matter in Fe(III)-rich Hawaiian soils of volcanic origin, and (ii) acetate, formed by the combined activity of fermentative and acetogenic bacteria, is an important trophic link in anoxic microsites of these soils.

  13. Development of 2-phenlethanol and acetic acid lures to monitor Obliquebanded leafroller (Lepidoptera: Tortricidae) under mating disruption

    USDA-ARS?s Scientific Manuscript database

    Studies were conducted to compare the relative attraction of the benzenoid plant volatiles 2-phenylethanol, phenylacetaldehyde, and phenylacetonitrile in combination with acetic acid as lures for male and female adults of the obliquebanded leafroller, Choristoneura rosaceana (Harris), in apple, Mal...

  14. Crystal structures of two solvates of (18-crown-6)potassium acetate.

    PubMed

    Liebing, Phil; Zaeni, Ahmad; Olbrich, Falk; Edelmann, Frank T

    2016-12-01

    The crystal and mol-ecular strutures of two solvated forms of [K(18 c 6)]OAc (18 c 6 = 18-crown-6 = 1,4,7,10,13,16-hexa-oxa-cyclo-octa-decane and OAc = acetate) were determined by single-crystal X-ray diffraction, namely (acetato-κ 2 O , O ')(1,4,7,10,13,16-hexa-oxa-cyclo-octa-decane-κ 6 O )potassium dihydrate, [K(CH 3 COO)(C 12 H 24 O 6 )]·2H 2 O ( 1 ) and (acetato-κ 2 O , O ')aqua-(1,4,7,10,13,16-hexa-oxa-cyclo-octa-decane-κ 6 O )potassium acetic acid monosolvate [K(CH 3 COO)(C 12 H 24 O 6 )(H 2 O)]·CH 3 COOH ( 2 ). In both compounds, the acetate anion is bonded to the potassium ion in a chelating fashion and the metal atom is consequently slightly displaced from the O 6 plane of the crown ether. In the crystals, O-H⋯O hydrogen bonds lead to a polymeric ladder structure in the dihydrate 1 , while the acetic acid hydrate 2 features inversion dimers.

  15. Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications

    PubMed Central

    Ferro, Suellen; Azevedo-Silva, João; Casal, Margarida; Côrte-Real, Manuela; Baltazar, Fatima; Preto, Ana

    2016-01-01

    Acetate, together with other short chain fatty acids has been implicated in colorectal cancer (CRC) prevention/therapy. Acetate was shown to induce apoptosis in CRC cells. The precise mechanism underlying acetate transport across CRC cells membrane, that may be implicated in its selectivity towards CRC cells, is not fully understood and was addressed here. We also assessed the effect of acetate in CRC glycolytic metabolism and explored its use in combination with the glycolytic inhibitor 3-bromopyruvate (3BP). We provide evidence that acetate enters CRC cells by the secondary active transporters MCT1 and/or MCT2 and SMCT1 as well as by facilitated diffusion via aquaporins. CRC cell exposure to acetate upregulates the expression of MCT1, MCT4 and CD147, while promoting MCT1 plasma membrane localization. We also observed that acetate increases CRC cell glycolytic phenotype and that acetate-induced apoptosis and anti-proliferative effect was potentiated by 3BP. Our data suggest that acetate selectivity towards CRC cells might be explained by the fact that aquaporins and MCTs are found overexpressed in CRC clinical cases. Our work highlights the importance that acetate transport regulation has in the use of drugs such as 3BP as a new therapeutic strategy for CRC. PMID:28874966

  16. Antibiofilm Properties of Acetic Acid

    PubMed Central

    Bjarnsholt, Thomas; Alhede, Morten; Jensen, Peter Østrup; Nielsen, Anne K.; Johansen, Helle Krogh; Homøe, Preben; Høiby, Niels; Givskov, Michael; Kirketerp-Møller, Klaus

    2015-01-01

    Bacterial biofilms are known to be extremely tolerant toward antibiotics and other antimicrobial agents. These biofilms cause the persistence of chronic infections. Since antibiotics rarely resolve these infections, the only effective treatment of chronic infections is surgical removal of the infected implant, tissue, or organ and thereby the biofilm. Acetic acid is known for its antimicrobial effect on bacteria in general, but has never been thoroughly tested for its efficacy against bacterial biofilms. In this article, we describe complete eradication of both Gram-positive and Gram-negative biofilms using acetic acid both as a liquid and as a dry salt. In addition, we present our clinical experience of acetic acid treatment of chronic wounds. In conclusion, we here present the first comprehensive in vitro and in vivo testing of acetic acid against bacterial biofilms. PMID:26155378

  17. Efficacy of Acetic Acid against Listeria monocytogenes Attached to Poultry Skin during Refrigerated Storage

    PubMed Central

    Gonzalez-Fandos, Elena; Herrera, Barbara

    2014-01-01

    This work evaluates the effect of acetic acid dipping on the growth of L. monocytogenes on poultry legs stored at 4 °C for eight days. Fresh inoculated chicken legs were dipped into either a 1% or 2% acetic acid solution (v/v) or distilled water (control). Changes in mesophiles, psychrotrophs, Enterobacteriaceae counts and sensorial characteristics (odor, color, texture and overall appearance) were also evaluated. The shelf life of the samples washed with acetic acid was extended by at least two days over the control samples washed with distilled water. L. monocytogenes counts before decontamination were 5.57 log UFC/g, and after treatment with 2% acetic acid (Day 0), L. monocytogenes counts were 4.47 log UFC/g. Legs washed with 2% acetic acid showed a significant (p < 0.05) inhibitory effect on L. monocytogenes compared to control legs, with a decrease of about 1.31 log units after eight days of storage. Sensory quality was not adversely affected by acetic acid. This study demonstrates that while acetic acid did reduce populations of L. monocytogenes on meat, it did not completely inactivate the pathogen. The application of acetic acid may be used as an additional hurdle contributing to extend the shelf life of raw poultry and reducing populations of L. monocytogenes. PMID:28234335

  18. Acetate concentrations and oxidation in salt marsh sediments

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Acetate concentrations and rates of acetate oxidation and sulfate reduction were measured in S. alterniflora sediments in New Hampshire and Massachusetts. Pore water extracted from cores by squeezing or centrifugation contained in greater than 0.1 mM acetate and, in some instances, greater than 1.0 mM. Pore water sampled nondestructively contained much less acetate, often less than 0.01 mM. Acetate was associated with roots, and concentrations varied with changes in plant physiology. Acetate turnover was very low whether whole core or slurry incubations were used. Radiotracers injected directly into soils yielded rates of sulfate reduction and acetate oxidation not significantly different from core incubation techniques. Regardless of incubation method, acetate oxidation did not account for a substantial percentage of sulfate reduction. These results differ markedly from data for unvegetated coastal sediments where acetate levels are low, oxidation rate constants are high, and acetate oxication rates greatly exceed rates of sulfate reduction. The discrepancy between rates of acetate oxidation and sulfate reduction in these marsh soils may be due either to the utilization of substrates other than acetate by sulfate reducers or artifacts associated with measurements of organic utilization by rhizosphere bacteria. Care must be taken when interpreting data from salt marsh sediments since the release of material from roots during coring may affect the concentrations of certain compounds as well as influencing results obtained when sediment incubations are employed.

  19. Drug resistance marker-aided genome shuffling to improve acetic acid tolerance in Saccharomyces cerevisiae.

    PubMed

    Zheng, Dao-Qiong; Wu, Xue-Chang; Wang, Pin-Mei; Chi, Xiao-Qin; Tao, Xiang-Lin; Li, Ping; Jiang, Xin-Hang; Zhao, Yu-Hua

    2011-03-01

    Acetic acid existing in a culture medium is one of the most limiting constraints in yeast growth and viability during ethanol fermentation. To improve acetic acid tolerance in Saccharomyces cerevisiae strains, a drug resistance marker-aided genome shuffling approach with higher screen efficiency of shuffled mutants was developed in this work. Through two rounds of genome shuffling of ultraviolet mutants derived from the original strain 308, we obtained a shuffled strain YZ2, which shows significantly faster growth and higher cell viability under acetic acid stress. Ethanol production of YZ2 (within 60 h) was 21.6% higher than that of 308 when 0.5% (v/v) acetic acid was added to fermentation medium. Membrane integrity, higher in vivo activity of the H+-ATPase, and lower oxidative damage after acetic acid treatment are the possible reasons for the acetic acid-tolerance phenotype of YZ2. These results indicated that this novel genome shuffling approach is powerful to rapidly improve the complex traits of industrial yeast strains.

  20. Synthesis, molecular modelling, and preliminary anticonvulsant activity evaluation of novel naphthalen-2-yl acetate and 1,6-dithia-4,9-diazaspiro [4.4] nonane-3,8-dione derivatives.

    PubMed

    Ghareb, Nagat; Abdel Daim, Mohamed M; El-Sayed, Norhan M; Elgawish, Mohamed Saleh

    2017-04-01

    The synthesis, pharmacological evaluation and molecular modelling study of novel naphthalen-2-yl acetate and 1,6-dithia-4,9-diazaspiro [4.4]nonane-3,8-dione derivatives as potential anticonvulsant agents are described. The newly synthesized compounds were characterized by both analytical and spectral data. Alkylation of 1H-imidazole or substituted piperazine with 1-(2-naphthyl)-2-bromoethanone (2) gave naphthalen-2-yl 2-(1H-imidazol-1-yl) acetate (3) and naphthalen-2-yl 2-(substituted piperazin-1-yl) acetate (4-8). Moreover, condensation of naphthalen-2-yl 2-bromoacetate or 2-bromo-1-(naphthalen-2-yl) ethanone with hydrazine hydrate and acetylacetone resulted in the formation of the cyclic pyrazole products 9 and 13. Sonication of naphthalen-2-yl acetate (1) with 2-chloropyridine, 2-chloropyrimidine and 2-(chloromethyl) oxirane gave naphthalen-2-yl 2-(pyridin-2-yl) acetate (10), naphthalen-2-yl 2-(pyrimidin-2-yl) acetate (11) and naphthalen-2-yl-3-(oxiran-2-yl) propanoate (12) respectively. Cyclocondensation reaction of 2-iminothiazolidin-4-one (14) with thioglycolic acid, thiolactic acid and thiomalic acid gave 1,6-dithia-4,9-diazaspiro [4.4]nonane-3,8-dione derivatives (15-17). The compounds were testedin vivofor the anticonvulsant activity by delaying strychnine-induced seizures. The diazaspirononane (17) and 1-(2-naphthyl)-2-bromoethanone (2) showed a high significant delay in the onset of convulsion and prolongation of survival time compared to phenobarbital. The molecular modelling study of anticonvulsant activity of synthesized compounds showed a CNS depressant activity via modulation of benzodiazepine allosteric site in GABA-A receptors. Copyright © 2017 Elsevier Inc. All rights reserved.

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