21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... investigation of reports of possible toxic effects and renal damage due to misuse of the drug acetophenetidin..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements... Drugs, in December 1963, appointed an ad hoc Advisory Committee of Inquiry on Possible Nephrotoxicity...

21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of the drug were in fact responsible for kidney lesions and disease. The Commissioner of Food and... statement to the following effect: “Warning—This medication may damage the kidneys when used in large...

Towards an understanding of the molecular mechanism of solvation of drug molecules: a thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin.

PubMed

Perlovich, German L; Volkova, Tatyana V; Bauer-Brandl, Annette

2006-10-01

Temperature dependencies of saturated vapor pressure for the monoclinic modification of paracetamol (acetaminophen), acetanilide, and phenacetin (acetophenetidin) were measured and thermodynamic functions of sublimation calculated (paracetamol: DeltaGsub298=60.0 kJ/mol; DeltaHsub298=117.9+/-0.7 kJ/mol; DeltaSsub298=190+/-2 J/mol.K; acetanilide: DeltaGsub298=40.5 kJ/mol; DeltaHsub298=99.8+/-0.8 kJ/mol; DeltaSsub298=197+/-2 J/mol.K; phenacetin: DeltaGsub298=52.3 kJ/mol; DeltaHsub298=121.8+/-0.7 kJ/mol; DeltaSsub298=226+/-2 J/mol.K). Analysis of packing energies based on geometry optimization of molecules in the crystal lattices using diffraction data and the program Dmol3 was carried out. Parameters analyzed were: (a) energetic contribution of van der Waals forces and hydrogen bonding to the total packing energy; (b) contributions of fragments of the molecules to the packing energy. The fraction of hydrogen bond energy in the packing energy increases as: phenacetin (17.5%)