Science.gov

Sample records for achieve dramatic improvements

  1. Dramatic Cataplexy Improvement Following Right Parietal Surgery

    PubMed Central

    Fam, David J.; Shammi, Prathiba; Mainprize, Todd G.; Murray, Brian J.

    2015-01-01

    This is the case of a 34-year-old woman with severe narcolepsy with cataplexy who experienced a dramatic reduction in cataplexy symptoms after resection of a right parietal astrocytoma. The patient underwent detailed neurological exam, neuropsychological testing, polysomnography and multiple sleep latency testing following surgery. Citation: Fam DJ, Shammi P, Mainprize TG, Murray BJ. Dramatic cataplexy improvement following right parietal surgery. J Clin Sleep Med 2015;11(7):829–830. PMID:25902819

  2. Dramatic Improvements to Feature Based Stereo

    NASA Technical Reports Server (NTRS)

    Smelyansky, V. N.; Morris, R. D.; Kuehnel, F. O.; Maluf, D. A.; Cheeseman, P.

    2004-01-01

    The camera registration extracted from feature based stereo is usually considered sufficient to accurately localize the 3D points. However, for natural scenes the feature localization is not as precise as in man-made environments. This results in small camera registration errors. We show that even very small registration errors result in large errors in dense surface reconstruction. We describe a method for registering entire images to the inaccurate surface model. This gives small, but crucially important improvements to the camera parameters. The new registration gives dramatically better dense surface reconstruction.

  3. Dramatically Improve How and Where Academic Content Is Taught

    ERIC Educational Resources Information Center

    Hyslop, Alisha

    2007-01-01

    The fourth recommendation in ACTE's high school reform position statement is to dramatically improve how and where academic content is taught. Even as advanced academic course-taking and high school graduation requirements have increased, student achievement on national benchmarks has remained flat, and college remediation rates continue to…

  4. DRAMATIC IMPROVEMENTS IN CAUSTIC-SIDE SOLVENT EXTRACTION OF CESIUM THROUGH MORE EFFICIENT STRIPPING

    SciTech Connect

    Delmau, Laetitia Helene; Bazelaire, Eve; Bonnesen, Peter V; Engle, Nancy L; Gorbunova, Maryna; Haverlock, Tamara; Moyer, Bruce A; Ensor, Dale; Meadors, Viola M; Harmon, Ben; Bartsch, Richard A.; Surowiec, Malgorzata A.; Zhou, Hui

    2008-01-01

    Dramatic potential improvements to the chemistry of the Caustic-Side Solvent Extraction (CSSX) process are presented as related to enhancement of cesium stripping. The current process for removing cesium from the alkaline high-level waste (HLW) at the USDOE Savannah River Site employs acidic scrub and strip stages and shows remarkable extraction and selectivity properties for cesium. It was determined that cesium stripping can be greatly improved with caustic or near-neutral stages using sodium hydroxide and boric acid as scrub and strip solutions, respectively. Improvements can also be achieved by appending pH-sensitive functional groups to the calix[4]arene-crown-6 extractant. Addition of a proton-ionizable group to the calixarene frame leads to a dramatic "pH swing" of up to 6 orders of magnitude change in cesium distribution ratio.

  5. Dramatic Improvements in Beach Water Quality Following Gull Removal

    EPA Science Inventory

    Gulls are often cited as important contributors of fecal contamination to surface waters, and some recreational beaches have used gull control measures to improve microbial water quality. In this study, gulls were chased from a Lake Michigan beach using specially trained dogs, a...

  6. SAFETY IMPROVES DRAMATICALLY IN FLUOR HANFORD SOIL AND GROUNDWATER REMEDIATION PROJECT

    SciTech Connect

    GERBER MS

    2007-12-05

    This paper describes dramatic improvements in the safety record of the Soil and Groundwater Remediation Project (SGRP) at the Hanford Site in southeast Washington state over the past four years. During a period of enormous growth in project work and scope, contractor Fluor Hanford reduced injuries, accidents, and other safety-related incidents and enhanced a safety culture that earned the SGRP Star Status in the Department of Energy's (DOE's) Voluntary Protection Program (VPP) in 2007. This paper outlines the complex and multi-faceted work of Fluor Hanford's SGRP and details the steps taken by the project's Field Operations and Safety organizations to improve safety. Holding field safety meetings and walkdowns, broadening safety inspections, organizing employee safety councils, intensively flowing down safety requirements to subcontractors, and adopting other methods to achieve remarkable improvement in safety are discussed. The roles of management, labor and subcontractors are detailed. Finally, SGRP's safety improvements are discussed within the context of overall safety enhancements made by Fluor Hanford in the company's 11 years of managing nuclear waste cleanup at the Hanford Site.

  7. Safety Improves Dramatically In Fluor Hanford Soil and Groundwater Remediation Project

    SciTech Connect

    Foster, A.L.; Gerber, M.S.; VonBargen, B.H.

    2008-07-01

    This paper describes dramatic improvements in the safety record of the Soil and Groundwater Remediation Project (SGRP) at the Hanford Site in southeast Washington state over the past four years. During a period of enormous growth in project work and scope, contractor Fluor Hanford reduced injuries, accidents, and other safety-related incidents and enhanced a safety culture that earned the SGRP Star Status in the Department of Energy's (DOE's) Voluntary Protection Program (VPP) in 2007. This paper outlines the complex and multi-faceted work of Fluor Hanford's SGRP and details the steps taken by the project's Field Operations and Safety organizations to improve safety. Holding field safety meetings and walk-downs, broadening safety inspections, organizing employee safety councils, intensively flowing down safety requirements to subcontractors, and adopting other methods to achieve remarkable improvement in safety are discussed. The roles of management, labor and subcontractors are detailed. Finally, SGRP's safety improvements are discussed within the context of overall safety enhancements made by Fluor Hanford in the company's 11 years of managing nuclear waste cleanup at the Hanford Site. (authors)

  8. Unexpected, dramatic improvement in atrioventricular conduction during pacemaker implantation for apparent complete heart block.

    PubMed

    Dizon, Jose'; Wang, Huijian; Biviano, Angelo; Garan, Hasan

    2007-09-01

    We describe the case of a 29-year-old man with complete heart block after aortic and mitral valve surgery for bacterial endocarditis. Prior to pacemaker implantation, the patient had sinus bradycardia with third degree atrioventricular (AV) block. During testing of the atrial lead, the patient manifested intact AV conduction with a constant PR interval, which was robust up to 120 beats/min. This case represents a dramatic example of unexpected, improved AV conduction, perhaps a result of loss of Phase IV block. PMID:17725759

  9. Dramatic improvements in toughness in poly(lactide-co-glycolide) nanocomposites.

    PubMed

    Xu, Wei; Raychowdhury, Subhendu; Jiang, David D; Retsos, Haris; Giannelis, Emmanuel P

    2008-05-01

    Poly(lactide-co-glycolide) (PLG), a biocompatible and biodegradable polymer, is dramatically toughened by adding small amounts of surface modified clay nanoparticles. The elongation during tensile tests increases from 7% for the pure polymer to 210% for the nanocomposite, accompanied with a modest increase in modulus. In contrast, PLG nanocomposites based on fumed silica treated with hexamethyldisilazane show only modest improvements in toughness. Electron microscopy, X-ray scattering, rheometry, and dielectric relaxation spectroscopy are used to investigate the toughening mechanism. Multiple crazing occurs in the clay nanocomposite after yielding. Small angle X-ray scattering studies show significant orientation of the clay nanoparticles along the tensile stress direction during deformation. The clay nanocomposites show a new, slow relaxation mode, most likely due to interfacial adsorbption of PLG chains on the surface of the clay nanoparticles. The dramatic increase in toughness is attributed to physical crosslinks introduced by the clay nanoparticles, a mechanism absent in the PLG/silica nanocomposites. The physical crosslinks increase the brittle fracture strength of the polymer and, consequently, trigger a toughening mechanism via multiple crazing and shear yielding. PMID:18398925

  10. Emulating a crowded intracellular environment in vitro dramatically improves RT-PCR performance

    SciTech Connect

    Lareu, Ricky R.; Harve, Karthik S.; Raghunath, Michael

    2007-11-09

    The polymerase chain reaction's (PCR) phenomenal success in advancing fields as diverse as Medicine, Agriculture, Conservation, or Paleontology is based on the ability of using isolated prokaryotic thermostable DNA polymerases in vitro to copy DNA irrespective of origin. This process occurs intracellularly and has evolved to function efficiently under crowded conditions, namely in an environment packed with macromolecules. However, current in vitro practice ignores this important biophysical parameter of life. In order to more closely emulate conditions of intracellular biochemistry in vitro we added inert macromolecules into reverse transcription (RT) and PCR. We show dramatic improvements in all parameters of RT-PCR including 8- to 10-fold greater sensitivity, enhanced polymerase processivity, higher specific amplicon yield, greater primer annealing and specificity, and enhanced DNA polymerase thermal stability. The faster and more efficient reaction kinetics was a consequence of the cumulative molecular and thermodynamic effects of the excluded volume effect created by macromolecular crowding.

  11. Dramatic improvement of crystals of large RNAs by cation replacement and dehydration

    PubMed Central

    Zhang, Jinwei; Ferré-D’Amare, Adrian R.

    2014-01-01

    Summary Compared to globular proteins, RNAs with complex three-dimensional folds are characterized by poorly differentiated molecular surfaces dominated by backbone phosphates, sparse tertiary contacts stabilizing global architecture, and conformational flexibility. The resulting generally poor order of crystals of large RNAs and their complexes frequently hampers crystallographic structure determination. We describe and rationalize a post-crystallization treatment strategy that exploits the importance of solvation and counterions for RNA folding. Replacement of Li+ and Mg2+ needed for growth of crystals of a tRNA-riboswitch-protein co-crystal with Sr2+, coupled with dehydration, dramatically improved the resolution limit (8.5 to 3.2 Å) and data quality, enabling structure determination. The soft Sr2+ ion forms numerous stabilizing intermolecular contacts. Comparison of pre- and post-treatment structures reveals how RNA assemblies redistribute as quasi-rigid bodies to yield improved crystal packing. Cation exchange complements previously reported post-crystallization dehydration of protein crystals, and represents a potentially general strategy for improving crystals of large RNAs. PMID:25185828

  12. Dramatic improvement of crystals of large RNAs by cation replacement and dehydration.

    PubMed

    Zhang, Jinwei; Ferré-D'Amaré, Adrian R

    2014-09-01

    Compared to globular proteins, RNAs with complex 3D folds are characterized by poorly differentiated molecular surfaces dominated by backbone phosphates, sparse tertiary contacts stabilizing global architecture, and conformational flexibility. The resulting generally poor order of crystals of large RNAs and their complexes frequently hampers crystallographic structure determination. We describe and rationalize a postcrystallization treatment strategy that exploits the importance of solvation and counterions for RNA folding. Replacement of Li(+) and Mg(2+) needed for growth of crystals of a tRNA-riboswitch-protein complex with Sr(2+), coupled with dehydration, dramatically improved the resolution limit (8.5-3.2 Å) and data quality, enabling structure determination. The soft Sr(2+) ion forms numerous stabilizing intermolecular contacts. Comparison of pre- and posttreatment structures reveals how RNA assemblies redistribute as quasi-rigid bodies to yield improved crystal packing. Cation exchange complements previously reported postcrystallization dehydration of protein crystals and represents a potentially general strategy for improving crystals of large RNAs. PMID:25185828

  13. Can Judges Improve Academic Achievement?

    ERIC Educational Resources Information Center

    Greene, Jay P.; Trivitt, Julie R.

    2008-01-01

    Over the last 3 decades student achievement has remained essentially unchanged in the United States, but not for a lack of spending. Over the same period a myriad of education reforms have been suggested and per-pupil spending has more than doubled. Since the 1990s the education reform attempts have frequently included judicial decisions to revise…

  14. Use of microsecond current prepulse for dramatic improvements of wire array Z-pinch implosion

    NASA Astrophysics Data System (ADS)

    Calamy, H.; Lassalle, F.; Loyen, A.; Zucchini, F.; Chittenden, J. P.; Hamann, F.; Maury, P.; Georges, A.; Bedoch, J. P.; Morell, A.

    2008-01-01

    The Sphinx machine [F. Lassalle et al., "Status on the SPHINX machine based on the 1microsecond LTD technology"] based on microsecond linear transformer driver (LTD) technology is used to implode an aluminium wire array with an outer diameter up to 140mm and maximum current from 3.5to5MA. 700to800ns implosion Z-pinch experiments are performed on this driver essentially with aluminium. Best results obtained before the improvement described in this paper were 1-3TW radial total power, 100-300kJ total yield, and 20-30kJ energy above 1keV. An auxiliary generator was added to the Sphinx machine in order to allow a multi microsecond current to be injected through the wire array load before the start of the main current. Amplitude and duration of this current prepulse are adjustable, with maxima ˜10kA and 50μs. This prepulse dramatically changes the ablation phase leading to an improvement of the axial homogeneity of both the implosion and the final radiating column. Total power was multiplied by a factor of 6, total yield by a factor of 2.5 with a reproducible behavior. This paper presents experimental results, magnetohydrodynamic simulations, and analysis of the effect of such a long current prepulse.

  15. Use of microsecond current prepulse for dramatic improvements of wire array Z-pinch implosion

    SciTech Connect

    Calamy, H.; Lassalle, F.; Loyen, A.; Zucchini, F.; Chittenden, J. P.; Hamann, F.; Maury, P.; Georges, A.; Bedoch, J. P.; Morell, A.

    2008-01-15

    The Sphinx machine [F. Lassalle et al., 'Status on the SPHINX machine based on the 1microsecond LTD technology'] based on microsecond linear transformer driver (LTD) technology is used to implode an aluminium wire array with an outer diameter up to 140 mm and maximum current from 3.5 to 5 MA. 700 to 800 ns implosion Z-pinch experiments are performed on this driver essentially with aluminium. Best results obtained before the improvement described in this paper were 1-3 TW radial total power, 100-300 kJ total yield, and 20-30 kJ energy above 1 keV. An auxiliary generator was added to the Sphinx machine in order to allow a multi microsecond current to be injected through the wire array load before the start of the main current. Amplitude and duration of this current prepulse are adjustable, with maxima {approx}10 kA and 50 {mu}s. This prepulse dramatically changes the ablation phase leading to an improvement of the axial homogeneity of both the implosion and the final radiating column. Total power was multiplied by a factor of 6, total yield by a factor of 2.5 with a reproducible behavior. This paper presents experimental results, magnetohydrodynamic simulations, and analysis of the effect of such a long current prepulse.

  16. Improving Achievement in Gaelic. Improving Series

    ERIC Educational Resources Information Center

    Her Majesty's Inspectorate of Education, 2005

    2005-01-01

    The aim of this report is to provide an overview of the development of provision for Gaelic education in Scottish schools, 11 years on from the Inspectorate's last major review of the area. The report sets out to provide an update showing what progress has been achieved since that time, with a specific focus on pre-school, primary and secondary…

  17. Dramatic improvement of anti-SS-A/Ro-associated interstitial lung disease after immunosuppressive treatment.

    PubMed

    Paola, Caramaschi; Giuliana, Festi; Giovanni, Orsolini; Cristian, Caimmi; Domenico, Biasi

    2016-07-01

    The aim of the study was to report three patients affected by interstitial lung disease associated with positive anti-SS-A/Ro autoantibody who showed a dramatic improvement after immunosuppressive treatment. Medical charts were reviewed to obtain clinical data, laboratory parameters, lung function tests, high-resolution computed tomography results and response to immunosuppressive treatment. The three patients showed a clinical picture of a lung-dominant connective tissue disease characterized by a sudden onset with dyspnea, cough and subtle extrathoracic features together with positive anti-SS-A/Ro antibody and weak titer antinuclear antibodies. All three patients responded favorably to immunosuppressive therapy: Two cases were treated with a combination of corticosteroid and cyclophosphamide followed by mycophenolate mofetil; in the third patient, clinical benefit was obtained after rituximab was added to corticosteroid and immunosuppressant drug. In spite of an abrupt onset with significant lung function impairment, all three patients had a favorable clinical response to immunosuppressive therapy. This report may be useful in making therapeutic decisions in case of interstitial lung disease associated with anti-SS-A antibody. PMID:27021338

  18. Correcting Inadequate Model Snow Process Descriptions Dramatically Improves Mountain Hydrology Simulations

    NASA Astrophysics Data System (ADS)

    Pomeroy, J. W.; Fang, X.

    2014-12-01

    The vast effort in hydrology devoted to parameter calibration as a means to improve model performance assumes that the models concerned are not fundamentally wrong. By focussing on finding optimal parameter sets and ascribing poor model performance to parameter or data uncertainty, these efforts may fail to consider the need to improve models with more intelligent descriptions of hydrological processes. To test this hypothesis, a flexible physically based hydrological model including a full suite of snow hydrology processes as well as warm season, hillslope and groundwater hydrology was applied to Marmot Creek Research Basin, Canadian Rocky Mountains where excellent driving meteorology and basin biophysical descriptions exist. Model parameters were set from values found in the basin or from similar environments; no parameters were calibrated. The model was tested against snow surveys and streamflow observations. The model used algorithms that describe snow redistribution, sublimation and forest canopy effects on snowmelt and evaporative processes that are rarely implemented in hydrological models. To investigate the contribution of these processes to model predictive capability, the model was "falsified" by deleting parameterisations for forest canopy snow mass and energy, blowing snow, intercepted rain evaporation, and sublimation. Model falsification by ignoring forest canopy processes contributed to a large increase in SWE errors for forested portions of the research basin with RMSE increasing from 19 to 55 mm and mean bias (MB) increasing from 0.004 to 0.62. In the alpine tundra portion, removing blowing processes resulted in an increase in model SWE MB from 0.04 to 2.55 on north-facing slopes and -0.006 to -0.48 on south-facing slopes. Eliminating these algorithms degraded streamflow prediction with the Nash Sutcliffe efficiency dropping from 0.58 to 0.22 and MB increasing from 0.01 to 0.09. These results show dramatic model improvements by including snow

  19. [A case of progressive supranuclear palsy dramatically improved with L-threo-3,4-dihydroxyphenylserine].

    PubMed

    Maruyama, T; Tamaru, F; Yamagisawa, N

    1992-06-01

    We report a 67-year-old female with progressive supranuclear palsy (PSP) who dramatically improved when given L-threo-3,4-dihydroxyphenylserine (L-DOPS). This patient developed dysarthria, lack of facial expression, and slowness at age 64. She was admitted to a local hospital, diagnosed as having parkinsonism and treated with antiparkinsonian drugs. Despite this treatment, she had difficulty in turning over in bed and standing up from a seat, and began to fall backward at age 65. One year later, she had trouble in walking due to frequent falls and became bedridden. The patient was admitted to our hospital in July 1991 under treatment with 20 mg/200 mg of carbidopa/L-dopa and 4 mg of trihexyphenydyl hydrochloride per day. Neurological examination revealed masked face, pseudobulbar palsy, and dystonic rigidity of the neck and upper trunk. Eye movements were normal except for impaired vertical saccades and convergence inability. Deep tendon reflexes were generally brisk and the plantar responses were flexor bilaterally. Tests of pulsion showed that her postural reflex was markedly disturbed, especially in retropulsion. Her gait showed severe unsteadiness. Neuropsychological tests showed intellectual impairment, frontal lobe dysfunction, and memory disturbance. Computed tomography showed an atrophic midbrain with prominent enlargement of ambient and quadrigeminal plate cisterns. Single photon emission computed tomography (SPECT) using 123-I-isopropyl-iodoamphetamine demonstrated marked frontal hypoperfusion. L-DOPS was administered at a dose of 100 mg per day and gradually increased up to 600 mg per day over a period of five weeks, while carbidopa/L-dopa and trihexyphenidyl hydrochloride were continued as on admission.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1424339

  20. Performing History: The Effects of a Dramatic Art-Based History Program on Student Achievement and Enjoyment

    ERIC Educational Resources Information Center

    Otten, Mark; Stigler, James W.; Woodward, J. Arthur; Staley, Lisle

    2004-01-01

    This study examines the influence of a dramatic art-based history program for fifth-grade students on both their learning and enjoyment of history. The program, called "Performing History," reflects theories of effective use of drama in the classroom as well as successful ways to teach history. The program presents historical information as part…

  1. Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

    PubMed Central

    Farboud, Behnom; Meyer, Barbara J.

    2015-01-01

    Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs with a GG motif at the 3′ end of their target-specific sequences. All guides designed using this simple principle induced a high frequency of targeted mutagenesis via nonhomologous end joining (NHEJ) and a high frequency of precise DNA integration from exogenous DNA templates via homology-directed repair (HDR). Related guide RNAs having the GG motif shifted by only three nucleotides showed severely reduced or no genome editing. We also combined the 3′ GG guide improvement with a co-CRISPR/co-conversion approach. For this co-conversion scheme, animals were only screened for genome editing at designated targets if they exhibited a dominant phenotype caused by Cas9-dependent editing of an unrelated target. Combining the two strategies further enhanced the ease of mutant recovery, thereby providing a powerful means to obtain desired genetic changes in an otherwise unaltered genome. PMID:25695951

  2. Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design.

    PubMed

    Farboud, Behnom; Meyer, Barbara J

    2015-04-01

    Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs with a GG motif at the 3' end of their target-specific sequences. All guides designed using this simple principle induced a high frequency of targeted mutagenesis via nonhomologous end joining (NHEJ) and a high frequency of precise DNA integration from exogenous DNA templates via homology-directed repair (HDR). Related guide RNAs having the GG motif shifted by only three nucleotides showed severely reduced or no genome editing. We also combined the 3' GG guide improvement with a co-CRISPR/co-conversion approach. For this co-conversion scheme, animals were only screened for genome editing at designated targets if they exhibited a dominant phenotype caused by Cas9-dependent editing of an unrelated target. Combining the two strategies further enhanced the ease of mutant recovery, thereby providing a powerful means to obtain desired genetic changes in an otherwise unaltered genome. PMID:25695951

  3. Extended reach drilling advancements dramatically improve performance on Bass Strait wells

    SciTech Connect

    Santostefano, V.; Krepp, A.N.

    1994-12-31

    Esso Australia Ltd. (EAL) has been drilling deviated wells in Bass Strait since 1968. Recent technological developments have been employed on the Mackerel Infill Drilling Project, that have significantly improved EAL`s ability to drill Long Reach (LR)/Extended Reach (ER) wells more economically and consistently. The more notable achievements have been: advancements in hole condition reporting, utilizing torque and drag monitoring; the successful use of non-rotating drillpipe rubbers to reduce surface torque to acceptable levels; deeper casing setting depths, to minimize torque and drag, and to reduce time-dependent hole problems; the use of inhibitive/encapsulating mud systems for control of reactive clays/shales; and use of wellbore stability modeling. These advancements have helped EAL to drill 50% greater meterage than was expected in 1993, at 16% lower cost per meter. This paper chronicles the engineering decisions behind these advancements, their applications in the field, the success/failure story on Mackerel to date, and how these developments have been incorporated in EAL`s future well planning.

  4. Dramatic Science

    ERIC Educational Resources Information Center

    McGregor, Debbie; Precious, Wendy

    2010-01-01

    The setting: the science classroom. The characters: you and your students. The scene: Your students acting out scientific discoveries, modeling a frog's life cycle, mimicking the transition from liquid to solid. This is "dramatic science", a teaching approach that uses acting techniques to explore and develop young children's ideas about science.…

  5. Improving Student Achievement through Character Education.

    ERIC Educational Resources Information Center

    Finck, Chip; Hansen, Cynthia; Jensen, Jane

    This report describes a program for improving moral character to increase academic achievement. Targeted population consisted of middle school students in a growing middle class community in a northern suburb of Chicago, Illinois. The problem, an absence of proper moral character, was documented through data collected from discipline referrals to…

  6. Handbook of Research on Improving Student Achievement.

    ERIC Educational Resources Information Center

    Cawelti, Gordon, Ed.

    This handbook is designed to identify classroom practices that research has shown to result in higher student achievement. The fundamental idea behind this book is that in order to succeed, efforts to improve instruction must foucs on the existing knowledge base about effective teaching and learning. The chapters are: (1) "Introduction" (Gordon…

  7. Improving Student Achievement Using Expert Learning Systems

    ERIC Educational Resources Information Center

    Green, Ronny; Smith, Bob; Leech, Don

    2004-01-01

    Both educators and the public are demanding improvements in student achievement and school performance. However, students meeting the highest college admission standards are increasingly selecting fields of study other than teaching. How can we increase teacher competence when many of our brightest teacher prospects are going into other fields?…

  8. Improving Student Achievement through Alternative Assessments.

    ERIC Educational Resources Information Center

    Durning, Jermaine; Matyasec, Maryann

    An attempt was made to improve students' academic grades and students' opinions of themselves as learners through the use of alternative assessments. The format of mastery learning using the direct instruction practice model was combined with performance-based assessment to increase achievement, self-esteem, and higher level thinking skills.…

  9. Dramatic improvement of severe cryptococcosis-induced immune reconstitution syndrome with adalimumab in a renal transplant recipient.

    PubMed

    Scemla, A; Gerber, S; Duquesne, A; Parize, P; Martinez, F; Anglicheau, D; Snanoudj, R; Zuber, M; Bougnoux, M-E; Legendre, C; Lortholary, O

    2015-02-01

    In solid organ transplant recipients, immune reconstitution inflammatory syndrome (IRIS) is a rare complication of cryptococcosis, which may require steroids in its most severe forms. Here, we report the case of a renal transplant recipient who developed severe cryptococcal meningitis-associated IRIS 1 week after immunosuppression reduction. High-dose steroids failed to improve the disease. Finally, a recombinant human monoclonal tumor necrosis factor-α (TNF-α) antagonist, adalimumab, was prescribed, and the patient rapidly experienced dramatic neurological improvement. No IRIS relapse occurred within 14 months following adalimumab discontinuation. PMID:25611999

  10. Dramatic Teaching for Dramatic Learning

    ERIC Educational Resources Information Center

    Graves, Julie

    2010-01-01

    Ressler's "Dramatic Changes" is a powerful guide for anyone brave enough to create a space for young people to discuss sexual orientation and gender identity. Her accessible style and tangible suggestions describe a creative and educationally sound approach to supporting youth in thoughtfully wrestling with one of the most controversial social…

  11. Nanocellulose-based Translucent Diffuser for Optoelectronic Device Applications with Dramatic Improvement of Light Coupling.

    PubMed

    Wu, Wei; Tassi, Nancy G; Zhu, Hongli; Fang, Zhiqiang; Hu, Liangbing

    2015-12-01

    Nanocellulose is a biogenerated and biorenewable organic material. Using a process based on 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)/NaClO/NaBr system, a highly translucent and light-diffusive film consisting of many layers of nanocellulose fibers and wood pulp microfibers was made. The film demonstrates a combination of large optical transmittance of ∼90% and tunable diffuse transmission of up to ∼78% across the visible and near-infrared spectra. The detailed characterizations of the film indicate the combination of high optical transmittance and haze is due to the film's large packing density and microstructured surface. The superior optical properties make the film a translucent light diffuser and applicable for improving the efficiencies of optoelectronic devices such as thin-film silicon solar cells and organic light-emitting devices. PMID:26572592

  12. Dramatic Improvement of Crystal Quality for Low-temperature-grown Rabbit Muscle Aldolase

    SciTech Connect

    Park, H.; Rangarajan, E; Sygusch, J; Izard, T

    2010-01-01

    Rabbit muscle aldolase (RMA) was crystallized in complex with the low-complexity domain (LC4) of sorting nexin 9. Monoclinic crystals were obtained at room temperature that displayed large mosaicity and poor X-ray diffraction. However, orthorhombic RMA-LC4 crystals grown at 277 K under similar conditions exhibited low mosaicity, allowing data collection to 2.2 {angstrom} Bragg spacing and structure determination. It was concluded that the improvement of crystal quality as indicated by the higher resolution of the new RMA-LC4 complex crystals was a consequence of the introduction of new lattice contacts at lower temperature. The lattice contacts corresponded to an increased number of interactions between high-entropy side chains that mitigate the lattice strain incurred upon cryocooling and accompanying mosaic spread increases. The thermodynamically unfavorable immobilization of high-entropy side chains used in lattice formation was compensated by an entropic increase in the bulk-solvent content owing to the greater solvent content of the crystal lattice.

  13. Pancreatic cancer-improved care achievable

    PubMed Central

    Buanes, Trond A

    2014-01-01

    Pancreatic adenocarcinoma is one of the most aggressive cancers, and the decline in mortality observed in most other cancer diseases, has so far not taken place in pancreatic cancer. Complete tumor resection is a requirement for potential cure, and the reorganization of care in the direction of high patient-volume centers, offering multimodal treatment, has improved survival and Quality of Life. Also the rates and severity grade of complications are improving in high-volume pancreatic centers. One of the major problems worldwide is underutilization of surgery in resectable pancreatic cancer. Suboptimal investigation, follow up and oncological treatment outside specialized centers are additional key problems. New chemotherapeutic regimens like FOLFIRINOX have improved survival in patients with metastatic disease, and different adjuvant treatment options result in well documented survival benefit. Neoadjuvant treatment is highly relevant, but needs further evaluation. Also adjuvant immunotherapy, in the form of vaccination with synthetic K-Ras-peptides, has been shown to produce long term immunological memory in cytotoxic T-cells in long term survivors. Improvement in clinical outcome is already achievable and further progress is expected in the near future for patients treated with curative as well as palliative intention. PMID:25132756

  14. Improving Student Achievement in Math and Science

    NASA Technical Reports Server (NTRS)

    Sullivan, Nancy G.; Hamsa, Irene Schulz; Heath, Panagiota; Perry, Robert; White, Stacy J.

    1998-01-01

    As the new millennium approaches, a long anticipated reckoning for the education system of the United States is forthcoming, Years of school reform initiatives have not yielded the anticipated results. A particularly perplexing problem involves the lack of significant improvement of student achievement in math and science. Three "Partnership" projects represent collaborative efforts between Xavier University (XU) of Louisiana, Southern University of New Orleans (SUNO), Mississippi Valley State University (MVSU), and the National Aeronautics and Space Administration (NASA), Stennis Space Center (SSC), to enhance student achievement in math and science. These "Partnerships" are focused on students and teachers in federally designated rural and urban empowerment zones and enterprise communities. The major goals of the "Partnerships" include: (1) The identification and dissemination of key indices of success that account for high performance in math and science; (2) The education of pre-service and in-service secondary teachers in knowledge, skills, and competencies that enhance the instruction of high school math and science; (3) The development of faculty to enhance the quality of math and science courses in institutions of higher education; and (4) The incorporation of technology-based instruction in institutions of higher education. These goals will be achieved by the accomplishment of the following objectives: (1) Delineate significant ?best practices? that are responsible for enhancing student outcomes in math and science; (2) Recruit and retain pre-service teachers with undergraduate degrees in Biology, Math, Chemistry, or Physics in a graduate program, culminating with a Master of Arts in Curriculum and Instruction; (3) Provide faculty workshops and opportunities for travel to professional meetings for dissemination of NASA resources information; (4) Implement methodologies and assessment procedures utilizing performance-based applications of higher order

  15. [A case of Wernicke-Korsakoff syndrome with dramatic improvement in consciousness immediately after intravenous infusion of thiamine].

    PubMed

    Kikuchi, A; Chida, K; Misu, T; Okita, N; Nomura, H; Konno, H; Takase, S; Takeda, A; Itoyama, Y

    2000-01-01

    A 68-year-old man was hospitalized on March 4, 1998 for disturbances in consciousness. In 1995, he had received proximal subtotal gastrectomy and reconstructive surgery of the jejunal interposition for gastric cancer. Thereafter he had been taking enough food without the habit of taking liquor. In October 1997, his short term memory was becoming gradually worse. On February 12, 1998, he suffered from numbness in the feet, and then dysphagia, unsteady gait, and diplopia developed gradually. On February 26, brain MRI showed no abnormalities. On March 3, he had a fever of 38.5 degrees C and his consciousness became unclear. Neurological examination revealed semi-coma, total ophthalmoplegia, and absence of doll's eye movement. Deep tendon reflexes were absent. The serum thiamine level was 9 ng/ml (normal range: 20-50). Brain MRI demonstrated symmetrical high intensity lesions in the periaqueductal area of the midbrain, dorsomedial nuclei of bilateral thalami, and vestibular nuclei. About 30 seconds after intravenous infusion of thiamine, his consciousness improved dramatically, but returned to semi-coma after about two minutes. Wernicke-Korsakoff syndrome usually occurs acutely. In the present case, however, the disease showed slow onset, chronic progression, and then rapid worsening after fever. Reconstructive surgery of the jejunal interposition might have caused the slow onset of Wernicke-Korsakoff syndrome, and fever might have facilitated the rapid progression of the disease. An immediate high concentration of thiamine modifies the kinetics of acetylcholine receptor ion channels, thereby maintaining wakefulness, and the level of consciousness may change dramatically. PMID:10689693

  16. Do Charter Schools Improve Student Achievement?

    ERIC Educational Resources Information Center

    Clark, Melissa A.; Gleason, Philip M.; Tuttle, Christina Clark; Silverberg, Marsha K.

    2015-01-01

    This article presents findings from a lottery-based study of the impacts of a broad set of 33 charter middle schools across 13 states on student achievement. To estimate charter school impacts, we compare test score outcomes of students admitted to these schools through the randomized admissions lotteries with outcomes of applicants who were not…

  17. Proven Strategies for Improving Learning & Achievement.

    ERIC Educational Resources Information Center

    Brown, Duane

    The purpose of this book is to give student support personnel tools that: (1) will be recognized by educators as directly related to enhancing academic performance; (2) can be used with confidence that they will have the desired impact on achievement; and (3) are culturally sensitive. Chapters contain detailed presentation of the technology as…

  18. Reshaping Personnel Policies to Improve Student Achievement

    ERIC Educational Resources Information Center

    Koppich, Julia E.; Gerstein, Amy

    2007-01-01

    The "Getting Down to Facts" (GDTF) studies released in March 2007 offered a clear diagnosis of the issues facing California's education system. Now, as California moves beyond the facts and begins the search for ways to improve the performance of California schools and students, the state faces a critical policy dilemma. On the one hand, the…

  19. Strategic School Funding for Improved Student Achievement

    ERIC Educational Resources Information Center

    Chambers, Jay G.; Brown, James R.; Levin, Jesse; Jubb, Steve; Harper, Dorothy; Tolleson, Ray; Manship, Karen

    2010-01-01

    This article features Strategic School Funding for Results (SSFR) project, a new joint initiative of the American Institutes for Research (AIR) and Pivot Learning Partners (PLP) aimed at improving school finance, human resources, and management systems in large urban school districts. The goal of the project is to develop and implement more…

  20. A Rural School/Community: A Case Study of a Dramatic Turnaround & Its Implications for School Improvement.

    ERIC Educational Resources Information Center

    Carlson, Robert V.

    This paper presents a case study of a rural community exhibiting a dramatic turnaround in community support for a new school bond issue. Demographic change was partly responsible for the change in community attitudes, with two waves of immigration altering the long-term conservative orientation of this community. After a series of failed…

  1. Microstructured fiber@HZSM-5 core-shell catalysts with dramatic selectivity and stability improvement for the methanol-to-propylene process.

    PubMed

    Wang, Xiangyu; Wen, Ming; Wang, Chunzheng; Ding, Jia; Sun, Ying; Liu, Ye; Lu, Yong

    2014-06-18

    We report a macroscopic stainless-steel-fiber@HZSM-5 core-shell catalyst by direct growth of 27 wt% HZSM-5 on a 3D microfibrous structure using 20 μm SS fibers, demonstrating dramatic selectivity and stability improvement in the MTP process. The unprecedented performance is due to the promotion of the olefin methylation/cracking cycle in methanol-to-hydrocarbon catalysis. PMID:24798420

  2. Science Achievement for All: Improving Science Performance and Closing Achievement Gaps

    ERIC Educational Resources Information Center

    Jackson, Julie K.; Ash, Gwynne

    2012-01-01

    This article addresses the serious and growing need to improve science instruction and science achievement for all students. We will describe the results of a 3-year study that transformed science instruction and student achievement at two high-poverty ethnically diverse public elementary schools in Texas. The school-wide intervention included…

  3. Science Achievement for All: Improving Science Performance and Closing Achievement Gaps

    NASA Astrophysics Data System (ADS)

    Jackson, Julie K.; Ash, Gwynne

    2012-11-01

    This article addresses the serious and growing need to improve science instruction and science achievement for all students. We will describe the results of a 3-year study that transformed science instruction and student achievement at two high-poverty ethnically diverse public elementary schools in Texas. The school-wide intervention included purposeful planning, inquiry science instruction, and contextually rich academic science vocabulary development. In combination, these instructional practices rapidly improved student-science learning outcomes and narrowed achievement gaps across diverse student populations.

  4. Finishing the Job: Improving the Achievement of Vocational Students.

    ERIC Educational Resources Information Center

    Bottoms, Gene; Presson, Alice

    The Southern Regional Education Board (SREB)-State Vocational Education Consortium's commitment to higher standards for and greater achievement of vocational students has brought substantial gains in student performance. SREB's High Schools That Work (HSTW), a school improvement initiative, documents achievement gains by vocational students. Data…

  5. How Much Can Spatial Training Improve STEM Achievement?

    ERIC Educational Resources Information Center

    Stieff, Mike; Uttal, David

    2015-01-01

    Spatial training has been indicated as a possible solution for improving Science, Technology, Engineering, and Mathematics (STEM) achievement and degree attainment. Advocates for this approach have noted that the correlation between spatial ability and several measures of STEM achievement suggests that spatial training should focus on improving…

  6. Improvements in Interval Time Tracking and Effects on Reading Achievement

    ERIC Educational Resources Information Center

    Taub, Gordon E.; McGrew, Kevin S.; Keith, Timothy Z.

    2007-01-01

    This study examined the effect of improvements in timing/rhythmicity on students' reading achievement. 86 participants completed pre- and post-test measures of reading achievement (i.e., Woodcock-Johnson III, Comprehensive Test of Phonological Processing, Test of Word Reading Efficiency, and Test of Silent Word Reading Fluency). Students in the…

  7. DEER Sensitivity between Iron Centers and Nitroxides in Heme-Containing Proteins Improves Dramatically Using Broadband, High-Field EPR

    PubMed Central

    2016-01-01

    This work demonstrates the feasibility of making sensitive nanometer distance measurements between Fe(III) heme centers and nitroxide spin labels in proteins using the double electron–electron resonance (DEER) pulsed EPR technique at 94 GHz. Techniques to measure accurately long distances in many classes of heme proteins using DEER are currently strongly limited by sensitivity. In this paper we demonstrate sensitivity gains of more than 30 times compared with previous lower frequency (X-band) DEER measurements on both human neuroglobin and sperm whale myoglobin. This is achieved by taking advantage of recent instrumental advances, employing wideband excitation techniques based on composite pulses and exploiting more favorable relaxation properties of low-spin Fe(III) in high magnetic fields. This gain in sensitivity potentially allows the DEER technique to be routinely used as a sensitive probe of structure and conformation in the large number of heme and many other metalloproteins. PMID:27035368

  8. DEER Sensitivity between Iron Centers and Nitroxides in Heme-Containing Proteins Improves Dramatically Using Broadband, High-Field EPR.

    PubMed

    Motion, Claire L; Lovett, Janet E; Bell, Stacey; Cassidy, Scott L; Cruickshank, Paul A S; Bolton, David R; Hunter, Robert I; El Mkami, Hassane; Van Doorslaer, Sabine; Smith, Graham M

    2016-04-21

    This work demonstrates the feasibility of making sensitive nanometer distance measurements between Fe(III) heme centers and nitroxide spin labels in proteins using the double electron-electron resonance (DEER) pulsed EPR technique at 94 GHz. Techniques to measure accurately long distances in many classes of heme proteins using DEER are currently strongly limited by sensitivity. In this paper we demonstrate sensitivity gains of more than 30 times compared with previous lower frequency (X-band) DEER measurements on both human neuroglobin and sperm whale myoglobin. This is achieved by taking advantage of recent instrumental advances, employing wideband excitation techniques based on composite pulses and exploiting more favorable relaxation properties of low-spin Fe(III) in high magnetic fields. This gain in sensitivity potentially allows the DEER technique to be routinely used as a sensitive probe of structure and conformation in the large number of heme and many other metalloproteins. PMID:27035368

  9. Does Children's Academic Achievement Improve when Single Mothers Marry?

    ERIC Educational Resources Information Center

    Wagmiller, Robert L., Jr.; Gershoff, Elizabeth; Veliz, Philip; Clements, Margaret

    2010-01-01

    Promoting marriage, especially among low-income single mothers with children, is increasingly viewed as a promising public policy strategy for improving developmental outcomes for disadvantaged children. Previous research suggests, however, that children's academic achievement either does not improve or declines when single mothers marry. In this…

  10. An Action Plan for Improving Mediocre or Stagnant Student Achievement

    ERIC Educational Resources Information Center

    Redmond, Kimberley B.

    2013-01-01

    Although all of the schools in the target school system adhere to a school improvement process, achievement scores remain mediocre or stagnant within the overseas school in Italy that serves children of United States armed service members. To address this problem, this study explored the target school's improvement process to discover how…

  11. Professional Learning Communities That Initiate Improvement in Student Achievement

    ERIC Educational Resources Information Center

    Royer, Suzanne M.

    2012-01-01

    Quality teaching requires a strong practice of collaboration, an essential building block for educators to improve student achievement. Researchers have theorized that the implementation of a professional learning community (PLC) with resultant collaborative practices among teachers sustains academic improvement. The problem addressed specifically…

  12. Mechanistic Studies Lead to Dramatically Improved Reaction Conditions for the Cu-Catalyzed Asymmetric Hydroamination of Olefins.

    PubMed

    Bandar, Jeffrey S; Pirnot, Michael T; Buchwald, Stephen L

    2015-11-25

    Enantioselective copper(I) hydride (CuH)-catalyzed hydroamination has undergone significant development over the past several years. To gain a general understanding of the factors governing these reactions, kinetic and spectroscopic studies were performed on the CuH-catalyzed hydroamination of styrene. Reaction profile analysis, rate order assessment, and Hammett studies indicate that the turnover-limiting step is regeneration of the CuH catalyst by reaction with a silane, with a phosphine-ligated copper(I) benzoate as the catalyst resting state. Spectroscopic, electrospray ionization mass spectrometry, and nonlinear effect studies are consistent with a monomeric active catalyst. With this insight, targeted reagent optimization led to the development of an optimized protocol with an operationally simple setup (ligated copper(II) precatalyst, open to air) and short reaction times (<30 min). This improved protocol is amenable to a diverse range of alkene and alkyne substrate classes. PMID:26522837

  13. The contribution of research results to dramatic improvements in post-abortion care: Centre Hospitalier de Libreville, Gabon.

    PubMed

    Mayi-Tsonga, Sosthène; Assoumou, Pamphile; Olé, Boniface Sima; Ntamack, Jacques Bang; Meyé, Jean François; Souza, Maria Helena; Faúndes, Anibal

    2012-12-01

    In 2009, we published an article in RHM showing a large delay in provision of emergency obstetric care to women who died from unsafe abortion complications at the Centre Hospitalier de Libreville. The paper raised awareness among hospital and government authorities of a serious delay in timely treatment, and they supported the recommendation of the hospital's Maternal Mortality Committee to greatly reduce the delay and also improve the care of women with abortion complications. Training in manual vacuum aspiration (MVA) for uterine evacuation was introduced, for use by midwives as well as obstetrician-gynaecologists, with local anaesthesia. The mean delay in providing care to women with abortion complications in the 2008 findings was compared to data from the five months from 1 November 2011 through 31 March 2012. In 2008, all incomplete abortions were treated by physicians with dilatation & evacuation (D&C) or electric vacuum aspiration (EVA) with general anaesthesia. In 2011-12, two-thirds of women were treated with manual vacuum aspiration with local anaesthesia instead, one half of them by midwives. The mean delay between presentation and treatment was 18.0 hours in 2008 and 1.8 hours in 2011-12. The mean delay did not differ between women treated with MVA or D&C/EVA, nor if treated by midwives or physicians. PMID:23245404

  14. A case of shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after a single dose of thiamine.

    PubMed

    Kim, Jihye; Park, Sooyun; Kim, Jun-Hyun; Kim, Sun Woong; Kang, Won Chan; Kim, Sun Jong

    2014-01-01

    Shoshin beriberi is a fulminant form of cardiac beriberi caused by thiamine deficiency. We report on a case of an 87-year-old man with shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after thiamine administration. Because of the rarity of the occurrence, lack of diagnostic test and atypical presentation, diagnosing shoshin beriberi is challenging and requires a high index of clinical suspicion. Shoshin beriberi leads to rapid haemodynamic collapse and death. Therefore, clinicians should consider shoshin beriberi (or cardiac beriberi) as one of the differential diagnoses in patients with heart failure or cardiogenic shock. PMID:25625639

  15. Improving the Teaching of Economics: Achievements and Aspirations.

    ERIC Educational Resources Information Center

    Bach, G. L.; Kelley, Allen C.

    Achievements and possible future projects of the American Economic Association's Committee on Economic Education (CEE), whose goal is to improve teaching in college and university economics, are discussed. The Teacher Training Program (TTP) was established by the CEE in the 1970's to develop programs to train economic educators. To date the…

  16. Using Students' Cultural Heritage to Improve Academic Achievement in Writing

    ERIC Educational Resources Information Center

    Mendez, Gilbert

    2006-01-01

    This article discusses an approach to teaching used at Calexico Unified School District, a California-Mexican border high school, by a group of teachers working to make teaching and learning more relevant to Chicano and Mexican students' lives and to improve their academic achievement in writing. An off-shoot of a training program for English…

  17. Improving Students' Social Skills and Achievement through Cooperative Learning.

    ERIC Educational Resources Information Center

    Caparos, Jennifer; Cetera, Colleen; Ogden, Lynn; Rossett, Kathryn

    This action research project evaluated a program designed to increase the use of appropriate social skills and improve academic achievement. The targeted population was comprised of first through third graders in four separate communities located in northeast Illinois. Evidence of the problem included teacher observational checklists denoting…

  18. Using Site-Based Budgeting To Improve Student Achievement.

    ERIC Educational Resources Information Center

    Warden, Christina

    2002-01-01

    Advances the use of school-based budgeting to improve student achievement. Describes four steps to implementing school-based budgeting: Access the current situation, set priorities and make decisions, plan action steps and benchmarks, and analyze choices and build the budget. Includes case study of the implementation of school-based budgeting at…

  19. Systems Thinking: A Skill to Improve Student Achievement

    ERIC Educational Resources Information Center

    Thornton, Bill; Peltier, Gary; Perreault, George

    2004-01-01

    This article examines how schools can avoid barriers to systems thinking in relation to improving student achievement. It then illustrates common errors associated with non-systems thinking and recommends solutions. Educators who understand that schools are complex interdependent social systems can move their organizations forward. Unfortunately,…

  20. New Directions in Social Psychological Interventions to Improve Academic Achievement

    ERIC Educational Resources Information Center

    Wilson, Timothy D.; Buttrick, Nicholas R.

    2016-01-01

    Attempts to improve student achievement typically focus on changing the educational environment (e.g., better schools, better teachers) or on personal characteristics of students (e.g., intelligence, self-control). The 6 articles in this special issue showcase an additional approach, emanating from social psychology, which focuses on students'…

  1. Understanding the Change Styles of Teachers to Improve Student Achievement

    ERIC Educational Resources Information Center

    Bigby, Arlene May Green

    2009-01-01

    The topic of this dissertation is the understanding of teacher change styles to improve student achievement. Teachers from public schools in a state located in the northern plains were surveyed regarding their Change Styles (preferred approaches to change) and flexibility scores. The results were statistically analyzed to determine if there were…

  2. Improving Student Achievement through the Use of Music Strategies.

    ERIC Educational Resources Information Center

    Brogla-Krupke, Cheryl

    This report describes a program to improve student achievement through the use of music strategies. The targeted population was fifth-grade students in a small Iowa community. The absence of music integration into the social studies area was observed through data that displayed the lack of motivation and in-depth learning by the students. Analysis…

  3. Dramatic improvement in decompensated right heart failure due to severe tricuspid regurgitation following ligation of arteriovenous fistula in a renal transplant recipient.

    PubMed

    Rao, Nitesh; Worthley, Matthew; Disney, Patrick; Faull, Randall

    2014-03-01

    Arteriovenous (AV) fistulas with high blood flow rate are necessary for adequate hemodialysis, but they can also cause significant hemodynamic changes, including raised cardiac output, left ventricular hypertrophy and occasionally overt cardiac failure (Basile et al., Nephrol Dial Transplant, 23, 2008, 282; Unger et al., Am J Transplant, 4, 2004, 2038). We now report a case of rapid and dramatic improvement in symptomatic right heart failure due to severe tricuspid regurgitation following ligation of an arteriovenous fistula. Cardiac magnetic resonance imaging (MRI) performed before and after the ligation of fistula showed striking improvement in both the tricuspid regurgitation and right ventricular dimensions, with minimal impact on left ventricular mass, size, and function. PMID:24118598

  4. Creative Dramatics. Beginnings Workshop.

    ERIC Educational Resources Information Center

    Gabriel, Julia; Sidlovskaya, Olga; Stotter, Ruth; Haugen, Kirsten; Leithold, Naomi

    2000-01-01

    Presents five articles on using creative dramatics in early childhood education: (1) "Drama: A Rehearsal for Life" (Julia Gabriel); (2) "Fairy Tales Enhance Imagination and Creative Thinking" (Olga Sidlovskaya); (3) "Starting with a Story" (Ruth Stotter); (4) "Using Creative Dramatics to Include All Children" (Kirsten Haugen); and (5) "Helping…

  5. Creative Dramatics Handbook.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA. Office of Early Childhood Programs.

    This handbook on creative dramatics at the elementary school level is primarily intended to assist the teacher who already has some training in creative dramatics. The handbook contains sections on (1) the philosophy and objectives of the program, including a discussion of an affective curriculum; (2) definitions of key concepts, including general…

  6. Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1.

    PubMed

    Huang, Boshi; Kang, Dongwei; Yang, Jiapei; Zhan, Peng; Liu, Xinyong

    2016-02-01

    Diarylpyrimidine and diaryltriazine derivatives, two representative structurally related classes of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with robust potencies against wild-type and several mutant strains of HIV-1, have attracted more and more attention in the last decade. However, they have been suffering from poor aqueous solubility. A series of novel diarylpyrimidines and diaryltriazines with solubilizing substituents attached to the central rings were reported as potent NNRTIs in the patent US20140378443A1. Some compounds exhibited potencies against wild-type HIV-1 which were comparable or even superior to those of dapivirine, etravirine and rilpivirine. In addition, dramatically enhanced solubilities were observed for these new compounds. Moreover, some structure optimization strategies for improving aqueous solubility are detailed in this review, providing new insights into development of next-generation NNRTIs endowed with favorable solubility. We anticipate that application of these strategies will ultimately lead to discovery of new anti-HIV drug candidates. PMID:26559996

  7. Why were alternating-current-driven electrochemiluminescence properties from Ru(bpy)3(2+) dramatically improved by the addition of titanium dioxide nanoparticles?

    PubMed

    Tsuneyasu, Shota; Ichihara, Kazuki; Nakamura, Kazuki; Kobayashi, Norihisa

    2016-06-28

    Electrochemiluminescence (ECL) is a phenomenon in which light is emitted from the excited state of a redox-active material generated by electrochemical reactions. Among light-emitting devices, ECL devices have various advantages in terms of structure and ease of fabrication, and therefore, they are expected to be next-generation emitting devices. In this study, we introduced rutile-type titanium dioxide nanoparticles (TiO2 NPs) in a Ru(ii)-complex-based electrolyte to improve the emission properties of an alternating current (AC)-driven ECL device. The properties of the ECL device with TiO2 NPs were greatly improved (emission luminescence, 165 cd m(-2); half-life time, 1000 s) compared to a previously reported AC-driven ECL device without nanoparticles. To determine how TiO2 NPs helped in achieving high emission luminescence and long-term stability, we measured the optical and electrochemical properties of the Ru(bpy)3(2+)-based ECL solution in detail. The PL intensity of Ru(bpy)3(2+) was increased by adding TiO2 NPs, which indicated that the suppression of non-radiative quenching of the complex's excited states could improve the ECL intensity. With respect to the enhanced stability, electron transfers between Ru(bpy)3(2+) and TiO2 were suggested by detailed electrochemical measurements. These electron transfers occurred from the reduced Ru(bpy)3(2+) species to the TiO2, and subsequently, from the TiO2 to the oxidized Ru(bpy)3(2+) species. Such electron transfers are thought to improve the balance of the redox reactions in the ECL device, leading to long-term stability. PMID:27253475

  8. Evidence that Smaller Schools Do Not Improve Student Achievement

    ERIC Educational Resources Information Center

    Wainer, Howard; Zwerling, Harris L.

    2006-01-01

    If more small schools than "expected" are among the high achievers, then creating more small schools would raise achievement across the board, many proponents of small schools have argued. In this article, the authors challenge the faulty logic of such inferences. Many claims have been made about the advantages of smaller schools. One is that,…

  9. Dramatic Developments in the Neurosciences Challenge Educators.

    ERIC Educational Resources Information Center

    Sylwester, Robert

    1986-01-01

    Recent dramatic developments in brain research and technology suggest that a comprehensive understanding of how the human brain works may soon be within reach. Just as the ability of the medical profession to treat patients improved dramatically with the advent of effective research skills and technology concerning the structure, biochemistry, and…

  10. Surface modification of alignment layer by ultraviolet irradiation to dramatically improve the detection limit of liquid-crystal-based immunoassay for the cancer biomarker CA125.

    PubMed

    Su, Hui-Wen; Lee, Mon-Juan; Lee, Wei

    2015-05-01

    Liquid crystal (LC)-based biosensing has attracted much attention in recent years. We focus on improving the detection limit of LC-based immunoassay techniques by surface modification of the surfactant alignment layer consisting of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP). The cancer biomarker CA125 was detected with an array of anti-CA125 antibodies immobilized on the ultraviolet (UV)-modified DMOAP monolayer. Compared with a pristine counterpart, UV irradiation enhanced the binding affinity of the CA125 antibody and reproducibility of immunodetection in which a detection limit of 0.01 ng∕ml for the cancer biomarker CA125 was achieved. Additionally, the optical texture observed under a crossed polarized microscope was correlated with the analyte concentration. In a proof-of-concept experiment using CA125-spiked human serum as the analyte, specific binding between the CA125 antigen and the anti-CA125 antibody resulted in a distinct and concentration-dependent optical response despite the high background caused by nonspecific binding of other biomolecules in the human serum. Results from this study indicate that UVmodification of the alignment layer, as well as detection with LCs of large birefringence, contributes to the enhanced performance of the label-free LC-based immunodetection, which may be considered a promising alternative to conventional label-based methods. PMID:26000796

  11. Surface modification of alignment layer by ultraviolet irradiation to dramatically improve the detection limit of liquid-crystal-based immunoassay for the cancer biomarker CA125

    NASA Astrophysics Data System (ADS)

    Su, Hui-Wen; Lee, Mon-Juan; Lee, Wei

    2015-05-01

    Liquid crystal (LC)-based biosensing has attracted much attention in recent years. We focus on improving the detection limit of LC-based immunoassay techniques by surface modification of the surfactant alignment layer consisting of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP). The cancer biomarker CA125 was detected with an array of anti-CA125 antibodies immobilized on the ultraviolet (UV)-modified DMOAP monolayer. Compared with a pristine counterpart, UV irradiation enhanced the binding affinity of the CA125 antibody and reproducibility of immunodetection in which a detection limit of 0.01 ng/ml for the cancer biomarker CA125 was achieved. Additionally, the optical texture observed under a crossed polarized microscope was correlated with the analyte concentration. In a proof-of-concept experiment using CA125-spiked human serum as the analyte, specific binding between the CA125 antigen and the anti-CA125 antibody resulted in a distinct and concentration-dependent optical response despite the high background caused by nonspecific binding of other biomolecules in the human serum. Results from this study indicate that UV modification of the alignment layer, as well as detection with LCs of large birefringence, contributes to the enhanced performance of the label-free LC-based immunodetection, which may be considered a promising alternative to conventional label-based methods.

  12. Healthcare systems engineering: an interdisciplinary approach to achieving continuous improvement.

    PubMed

    Wu, Bin; Klein, Cerry; Stone, Tamara T

    2006-01-01

    This paper argues that a systems approach can significantly enhance healthcare improvement efforts in patient safety, service quality and healthcare cost containment. The application of systems thinking to healthcare improvement encompasses three key principles: the systems perspective of healthcare processes, structured problem solving and the closed loop of continuous system improvement. These are encapsulated in a conceptual framework of continuous system improvement, which includes a reference architecture model and an analysis and design process model. Combined into a closed-loop, this framework allows users to understand and appropriately apply relevant functions, issues and analytical techniques. Practical applications of the framework are presented. PMID:18048245

  13. Partnering through Training and Practice to Achieve Performance Improvement

    ERIC Educational Resources Information Center

    Lyons, Paul R.

    2010-01-01

    This article presents a partnership effort among managers, trainers, and employees to spring to life performance improvement using the performance templates (P-T) approach. P-T represents a process model as well as a method of training leading to performance improvement. Not only does it add to our repertoire of training and performance management…

  14. Capacity Building for a School Improvement Program, Achievement Directed Leadership.

    ERIC Educational Resources Information Center

    Graeber, Anna O.; And Others

    This report describes and evaluates efforts to enhance school districts' capacity to implement and institutionalize the monitoring and management system for an instructional leadership program called Achievement Directed Leadership (ADL). Chapter one introduces the report's methodology, limitations, and structure. Chapter two first states the…

  15. Improving Secondary School Students' Achievement using Intrinsic Motivation

    ERIC Educational Resources Information Center

    Albrecht, Erik; Haapanen, Rebecca; Hall, Erin; Mantonya, Michelle

    2009-01-01

    This report describes a program for increasing students' intrinsic motivation in an effort to increase academic achievement. The targeted population consisted of secondary level students in a middle to upper-middle class suburban area. The students of the targeted secondary level classes appeared to be disengaged from learning due to a lack of…

  16. Does Video-Autotutorial Instruction Improve College Student Achievement?

    ERIC Educational Resources Information Center

    Fisher, K. M.; And Others

    1977-01-01

    Compares student achievement in an upper-division college introductory course taught by the video-autotutorial method with that in two comparable courses taught by the lecture-discussion method. Pre-post tests of 623 students reveal that video-autotutorial students outperform lecture/discussion participants at all ability levels and that in…

  17. Middle School Practices Improve Student Achievement in High Poverty Schools.

    ERIC Educational Resources Information Center

    Mertens, Steven B.; Flowers, Nancy

    2003-01-01

    Examined how interdisciplinary team practices and classroom instructional practices affected student achievement in high poverty middle schools in Arkansas, Louisiana, and Mississippi. Found that when the combined effects of family poverty level, teaming and common planning time, and duration of teaming were considered, there was a relationship…

  18. Helping Students Improve Academic Achievement and School Success Behavior

    ERIC Educational Resources Information Center

    Brigman, Greg; Campbell, Chari

    2003-01-01

    This article describes a study evaluating the impact of school-counselor-led interventions on student academic achievement and school success behavior. A group counseling and classroom guidance model called student success skills (SSS) was the primary intervention. The focus of the SSS model was on three sets of skills identified in several…

  19. Instruction and Achievement in Chicago Elementary Schools. Improving Chicago's Schools.

    ERIC Educational Resources Information Center

    Smith, Julia B.; Lee, Valerie E.; Newmann, Fred M.

    This study focused on the link between different forms of instruction and learning in Chicago, Illinois, elementary schools. It used teachers' survey reports about their instruction in the 1997-1997 school year and linked these reports with achievement gains. The study tested the common assumption that the nature of standardized assessments…

  20. An Effective Way to Improve Mathematics Achievement in Urban Schools

    ERIC Educational Resources Information Center

    Kim, Taik

    2010-01-01

    The local Gaining Early Awareness and Readiness for Undergraduate Programs (GEARUP) partnership serves 11 K-8 schools with the lowest achievement scores and the highest poverty rates in a large Midwestern urban district. Recently, GEARUP launched a specially designed teaching program, Mathematics Enhancement Group (MEG), for underachievers in…

  1. Dramatic reduction of culture time of Mycobacterium tuberculosis

    NASA Astrophysics Data System (ADS)

    Ghodbane, Ramzi; Raoult, Didier; Drancourt, Michel

    2014-02-01

    Mycobacterium tuberculosis culture, a critical technique for routine diagnosis of tuberculosis, takes more than two weeks. Here, step-by-step improvements in the protocol including a new medium, microaerophlic atmosphere or ascorbic-acid supplement and autofluorescence detection dramatically shortened this delay. In the best case, primary culture and rifampicin susceptibility testing were achieved in 72 hours when specimens were inoculated directly on the medium supplemented by antibiotic at the beginning of the culture.

  2. Organizational management practices for achieving software process improvement

    NASA Technical Reports Server (NTRS)

    Kandt, Ronald Kirk

    2004-01-01

    The crisis in developing software has been known for over thirty years. Problems that existed in developing software in the early days of computing still exist today. These problems include the delivery of low-quality products, actual development costs that exceed expected development costs, and actual development time that exceeds expected development time. Several solutions have been offered to overcome out inability to deliver high-quality software, on-time and within budget. One of these solutions involves software process improvement. However, such efforts often fail because of organizational management issues. This paper discusses business practices that organizations should follow to improve their chances of initiating and sustaining successful software process improvement efforts.

  3. Achieving process control through improved grinding techniques for ferrite materials

    SciTech Connect

    Bruce, J.

    1995-09-01

    In manufacturing soft ferrite materials the particle size of the raw material has a significant impact on the reactivity of calcination. The control of particle size distribution and final formulation at wet milling after calcining impacts the reactivity during sintering and the magnetic properties of the final product. This paper will deal with steps taken to improve process control during the grinding operations of raw material and calcine in soft ferrite production. Equipment modifications as well as changes to the grinding and material handling techniques will be included. All examples of process control and improvements will be supported by data.

  4. Achieving improved cycle efficiency via pressure gain combustors

    SciTech Connect

    Gemmen, R.S.; Janus, M.C.; Richards, G.A.; Norton, T.S.; Rogers, W.A.

    1995-04-01

    As part of the Department of Energy`s Advanced Gas Turbine Systems Program, an investigation is being performed to evaluate ``pressure gain`` combustion systems for gas turbine applications. This paper presents experimental pressure gain and pollutant emission data from such combustion systems. Numerical predictions for certain combustor geometries are also presented. It is reported that for suitable aerovalved pulse combustor geometries studied experimentally, an overall combustor pressure gain of nearly 1 percent can be achieved. It is also shown that for one combustion system operating under typical gas turbine conditions, NO{sub x} and CO emmissions, are about 30 ppmv and 8 ppmv, respectively.

  5. Feedback to achieve improved sign-out technique.

    PubMed

    Doers, Matthew E; Beniwal-Patel, Poonam; Kuester, Jessica; Fletcher, Kathlyn E

    2015-01-01

    To maximize the quality of sign-out documents within the internal medicine residency, a quality improvement intervention was developed and implemented. Written sign-outs were collected from general medicine ward teams and graded using an 11-point checklist; in-person feedback was then given directly to the ward teams. Documentation of many of the 11 elements improved: mental status (22% to 66%, P < .0001), decisionality (40% to 66%, P < .0001), lab/test results (63% to 69%, P < .0001), level of acuity (34% to 50%, P < .0001), anticipatory guidance (69% to 82%, P < .0001), and future plans (35% to 38%, P < .0005). The use of vague language declined (41% to 26%, P < .0001). The mean total scores improved from 7.0 to 8.2 out of a possible 11 (P < .0001). As new house staff rotated onto the services, improvement over time was sustained with 1 feedback session per team, per month. Similar interventions could be made in other programs and other institutions. PMID:24878514

  6. ACHIEVING IRRIGATION RETURN FLOW QUALITY CONTROL THROUGH IMPROVED LEGAL SYSTEMS

    EPA Science Inventory

    The key to irrigated agricultural return flow quality control is proper utilization and management of the resource itself, and an accepted tool in out society is the law. This project is designed to develop legal alternatives that will facilitate the implementation of improved wa...

  7. Community Schools Seek to Improve High School Achievement, College Readiness

    ERIC Educational Resources Information Center

    Gilroy, Marilyn

    2011-01-01

    The Coalition for Community Schools, an alliance of more than 150 national, state, and local organizations, is bringing public schools in partnership with community resources to improve student success. While that might seem like an abstract idea, it has very concrete goals, such as boosting high school graduation rates and college readiness.…

  8. Achieving Continuous Improvement: Theories that Support a System Change.

    ERIC Educational Resources Information Center

    Armel, Donald

    Focusing on improvement is different than focusing on quality, quantity, customer satisfaction, and productivity. This paper discusses Open System Theory, and suggests ways to change large systems. Changing a system (meaning the way all the parts are connected) requires a considerable amount of data gathering and analysis. Choosing the proper…

  9. Using Curriculum-Based Measurement to Improve Achievement

    ERIC Educational Resources Information Center

    Clarke, Suzanne

    2009-01-01

    Response to intervention (RTI) is on the radar screen of most principals these days--finding out what it is, how it can improve teaching and learning, and what needs to be done to implement it effectively. One critical component of RTI that will require particular attention from principals is student progress monitoring, which is required in every…

  10. Improving Student Achievement in Solving Mathematical Word Problems.

    ERIC Educational Resources Information Center

    Roti, Joan; Trahey, Carol; Zerafa, Susan

    This report describes a program for improving students' comprehension of the language of mathematical problems. The targeted population consists of 5th and 6th grade multi-age students and multi-age learners with special needs at a middle school located outside a major city in a Midwestern community. Evidence for the existence of this problem…

  11. Improving International Research with Clinical Specimens: 5 Achievable Objectives

    PubMed Central

    LaBaer, Joshua

    2012-01-01

    Our increased interest in translational research has created a large demand for blood, tissue and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this editorial, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping inter-observer differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do. PMID:22998582

  12. Student Achievement Goal Setting: Using Data to Improve Teaching and Learning

    ERIC Educational Resources Information Center

    Stronge, James H.; Grant, Leslie W.

    2009-01-01

    The first book in the James H. Stronge Research-to-Practice series focuses on improving student achievement through academic goal setting. It offers the tools and plan of action to use performance data to improve instructional practice and increase student achievement. The book is divided into three parts: (1) How Student Achievement Data Can Be…

  13. The Turnaround Challenge: Why America's Best Opportunity to Dramatically Improve Student Achievement Lies in Our Worst-Performing Schools. Supplement to the Main Report

    ERIC Educational Resources Information Center

    Calkins, Andrew; Guenther, William; Belfiore, Grace; Lash, Dave

    2007-01-01

    The turnaround recommendations and framework in "The Turnaround Challenge" grew out of both new research and synthesis of extensive existing research, as carried out by Mass Insight Education & Research Institute and its partners since September 2005. If the main report is the tip of the proverbial iceberg, this supplement represents at least part…

  14. Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer

    PubMed Central

    Borre, Pierre Vanden; Zurakowski, David; Kim, Yon Seon; Dennett, Kate Virginia; Amin, Salma; Freeman, Gordon James; Parangi, Sareh

    2016-01-01

    The interaction of programmed cell death-1 and its ligand is widely studied in cancer. Monoclonal antibodies blocking these molecules have had great success but little is known about them in thyroid cancer. We investigated the role of PD-L1 in thyroid cancer with respect to BRAF mutation and MAP kinase pathway activity and the effect of anti PD-L1 antibody therapy on tumor regression and intra-tumoral immune response alone or in combination with BRAF inhibitor (BRAFi). BRAFV600E cells showed significantly higher baseline expression of PD-L1 at mRNA and protein levels compared to BRAFWT cells. MEK inhibitor treatment resulted in a decrease of PD-L1 expression across all cell lines. BRAFi treatment decreased PD-L1 expression in BRAFV600E cells, but paradoxically increased its expression in BRAFWT cells. BRAFV600E mutated patients samples had a higher level of PD-L1 mRNA compared to BRAFWT (p=0.015). Immunocompetent mice (B6129SF1/J) implanted with syngeneic 3747 BRAFV600E/WT P53−/− murine tumor cells were randomized to control, PLX4720, anti PD-L1 antibody and their combination. In this model of aggressive thyroid cancer, control tumor volume reached 782.3±174.6mm3 at two weeks. The combination dramatically reduced tumor volume to 147.3±60.8, compared to PLX4720 (439.3±188.4 mm3, P=0.023) or PD-L1 antibody (716.7±62.1, P<0.001) alone. Immunohistochemistry analysis revealed intense CD8+ CTL infiltration and cytotoxicity and favorable CD8+:Treg ratio compared to each individual treatment. Our results show anti PD-L1 treatment potentiates the effect of BRAFi on tumor regression and intensifies anti tumor immune response in an immunocompetent model of ATC. Clinical trials of this therapeutic combination may be of benefit in patients with ATC. PMID:26943572

  15. Optimization of the GAFF force field to describe liquid crystal molecules: the path to a dramatic improvement in transition temperature predictions.

    PubMed

    Boyd, Nicola Jane; Wilson, Mark R

    2015-10-14

    The physical properties and phase transitions of thermotropic liquid crystals are highly sensitive to small changes in chemical structure. However, these changes are challenging to model, as both the phase diagram and mesophase properties obtained from fully atomistic simulations are strongly dependent on the force field model employed, and the current generation of chemical force fields has not proved accurate enough to provide reliable predictions of transition temperatures for many liquid crystals. This paper presents a strategy for improving the nematic clearing point, TNI, in atomistic simulations, by systematic optimization of the General Amber Force Field (GAFF) for key mesogenic fragments. We show that with careful optimization of the parameters describing a series of liquid crystal fragment molecules, it is possible to transfer these parameters to larger liquid crystal molecules and make accurate predictions for nematic mesophase formation. This new force field, GAFF-LCFF, is used to predict the nematic-isotropic clearing point to within 5 °C for the nematogen 1,3-benzenedicarboxylic acid,1,3-bis(4-butylphenyl)ester, an improvement of 60 °C over the standard GAFF force field. PMID:26343382

  16. Effects of Improvements in Interval Timing on the Mathematics Achievement of Elementary School Students

    ERIC Educational Resources Information Center

    Taub, Gordon E.; McGrew, Kevin S.; Keith, Timothy Z.

    2015-01-01

    This article examines the effect of improvements in timing/rhythmicity on mathematics achievement. A total of 86 participants attending 1st through 4th grades completed pre- and posttest measures of mathematics achievement from the Woodcock-Johnson III Tests of Achievement. Students in the experimental group participated in a 4-week intervention…

  17. Brain-state classification and a dual-state decoder dramatically improve the control of cursor movement through a brain-machine interface

    NASA Astrophysics Data System (ADS)

    Sachs, Nicholas A.; Ruiz-Torres, Ricardo; Perreault, Eric J.; Miller, Lee E.

    2016-02-01

    Objective. It is quite remarkable that brain machine interfaces (BMIs) can be used to control complex movements with fewer than 100 neurons. Success may be due in part to the limited range of dynamical conditions under which most BMIs are tested. Achieving high-quality control that spans these conditions with a single linear mapping will be more challenging. Even for simple reaching movements, existing BMIs must reduce the stochastic noise of neurons by averaging the control signals over time, instead of over the many neurons that normally control movement. This forces a compromise between a decoder with dynamics allowing rapid movement and one that allows postures to be maintained with little jitter. Our current work presents a method for addressing this compromise, which may also generalize to more highly varied dynamical situations, including movements with more greatly varying speed. Approach. We have developed a system that uses two independent Wiener filters as individual components in a single decoder, one optimized for movement, and the other for postural control. We computed an LDA classifier using the same neural inputs. The decoder combined the outputs of the two filters in proportion to the likelihood assigned by the classifier to each state. Main results. We have performed online experiments with two monkeys using this neural-classifier, dual-state decoder, comparing it to a standard, single-state decoder as well as to a dual-state decoder that switched states automatically based on the cursor’s proximity to a target. The performance of both monkeys using the classifier decoder was markedly better than that of the single-state decoder and comparable to the proximity decoder. Significance. We have demonstrated a novel strategy for dealing with the need to make rapid movements while also maintaining precise cursor control when approaching and stabilizing within targets. Further gains can undoubtedly be realized by optimizing the performance of the

  18. Poly(2,5-dimercapto-1,3,4-thiadiazole) as a cathode for rechargeable lithium batteries with dramatically improved performance.

    PubMed

    Gao, Jie; Lowe, Michael A; Conte, Sean; Burkhardt, Stephen E; Abruña, Héctor D

    2012-07-01

    Organosulfur compounds with multiple thiol groups are promising for high gravimetric energy density electrochemical energy storage. We have synthesized a poly(2,5-dimercapto-1,3,4-thiadiazole) (PDMcT)/poly(3,4-ethylenedioxythiophene) (PEDOT) composite cathode for lithium-ion batteries with a new method and investigated its electrochemical behavior by charge/discharge cycles and cyclic voltammetry (CV) in an ether-based electrolyte. Based on a comparison of the electrochemical performance with a carbonate-based electrolyte, we found a much higher discharge capacity, but also a very attractive cycling performance of PDMcT by using a tetra(ethylene glycol) dimethyl ether (TEGDME)-based electrolyte. The first discharge capacity of the as-synthesized PDMcT/PEDOT composite approached 210 mAh g(-1) in the TEGDME-based electrolyte. CV results clearly show that the redox reactions of PDMcT are highly reversible in this TEGDME-based electrolyte. The reversible capacity remained around 120 mAh g(-1) after 20 charge/discharge cycles. With improved cycling performance and very low cost, PDMcT could become a very promising cathode material when combined with a TEGDME-based electrolyte. The poor capacity in the carbonate-based electrolyte is a consequence of the irreversible reaction of the DMcT monomer and dimer with the solvent, emphasizing the importance of electrolyte chemistry when studying molecular-based battery materials. PMID:22644940

  19. Rapid Surface Cooling by ThermoSuit System Dramatically Reduces Scar Size, Prevents Post-Infarction Adverse Left Ventricular Remodeling, and Improves Cardiac Function in Rats

    PubMed Central

    Dai, Wangde; Herring, Michael J; Hale, Sharon L; Kloner, Robert A

    2015-01-01

    Background The long-term effects of transient hypothermia by the non-invasive ThermoSuit apparatus on myocardial infarct (MI) scar size, left ventricular (LV) remodeling, and LV function were assessed in rat MI model. Methods and Results Rats were randomized to normothermic or hypothermic groups (n=14 in each group) and subjected to 30 minutes coronary artery occlusion and 6 weeks of reperfusion. For hypothermia therapy, rats were placed into the ThermoSuit apparatus at 2 minutes after the onset of coronary artery occlusion, were taken out of the apparatus when the core body temperature reached 32°C (in ≈8 minutes), and were then allowed to rewarm. After 6 weeks of recovery, rats treated with hypothermia demonstrated markedly reduced scar size (expressed as % of left ventricular area: hypothermia, 6.5±1.1%; normothermia, 19.4±1.7%; P=1.3×10−6); and thicker anterior LV wall (hypothermia, 1.57±0.09 mm; normothermia, 1.07±0.05 mm; P=3.4×10−5); decreased postmortem left ventricular volume (hypothermia, 0.45±0.04 mL; normothermia, 0.6±0.03 mL; P=0.028); and better LV fractional shortening by echocardiography (hypothermia, 37.2±2.8%; normothermia, 18.9±2.3%; P=0.0002) and LV ejection fraction by LV contrast ventriculography (hypothermia, 66.8±2.3%; normothermia, 56.0±2.0%; P=0.0014). Conclusions Rapid, transient non-invasive surface cooling with the ThermoSuit apparatus in the acute phase of MI decreased scar size by 66.5%, attenuated adverse post-infarct left ventricular dilation and remodeling, and improved cardiac function in the chronic phase of experimental MI. PMID:26116692

  20. Creative Dramatics in Early Childhood

    ERIC Educational Resources Information Center

    Mandelbaum, Jean

    1975-01-01

    Offers suggestions as to how teachers of nursery through second grade children might develop a creative dramatics program from elements that are already in the curriculum and in the children themselves. (Author/SDH)

  1. Care initiation area yields dramatic results.

    PubMed

    2009-03-01

    The ED at Gaston Memorial Hospital in Gastonia, NC, has achieved dramatic results in key department metrics with a Care Initiation Area (CIA) and a physician in triage. Here's how the ED arrived at this winning solution: Leadership was trained in and implemented the Kaizen method, which eliminates redundant or inefficient process steps. Simulation software helped determine additional space needed by analyzing arrival patterns and other key data. After only two days of meetings, new ideas were implemented and tested. PMID:19275059

  2. Improving Reliability and Validity of "Achievement via Conformance" Through Computer Applications.

    ERIC Educational Resources Information Center

    Riggs, Donald E.

    This paper describes an experiment conducted in order to improve the reliability and validity of the Achievement via Conformance (AC) scale of the California Psychological Inventory (CPI). The primary goal of AC is to identify those factors of interest and motivation which facilitate achievement in any setting where conformance is positive…

  3. Effective Strategies Urban Superintendents Utilize That Improve the Academic Achievement for African American Males

    ERIC Educational Resources Information Center

    Prioleau, Lushandra

    2013-01-01

    This study examined the effective strategies, resources, and programs urban superintendents utilize to improve the academic achievement for African-American males. This study employed a mixed-methods approach to answer the following research questions regarding urban superintendents and the academic achievement for African-American males: What…

  4. Improving Education Achievement and Attainment in Luxembourg. OECD Economics Department Working Papers, No. 508

    ERIC Educational Resources Information Center

    Carey, David; Ernst, Ekkehard

    2006-01-01

    Improving education achievement in Luxembourg is a priority for strengthening productivity growth and enhancing residents' employment prospects in the private sector, where employers mainly hire cross-border workers. Student achievement in Luxembourg is below the OECD average according to the 2003 OECD PISA study, with the performance gap between…

  5. Improving Student Motivation and Achievement in Mathematics through Teaching to the Multiple Intelligences.

    ERIC Educational Resources Information Center

    Bednar, Janet; Coughlin, Jane; Evans, Elizabeth; Sievers, Theresa

    This action research project described strategies for improving student motivation and achievement in mathematics through multiple intelligences. The targeted population consisted of kindergarten, third, fourth, and fifth grade students located in two major Midwestern cities. Documentation proving low student motivation and achievement in…

  6. Breaking through barriers: using technology to address executive function weaknesses and improve student achievement.

    PubMed

    Schwartz, David M

    2014-01-01

    Assistive technologies provide significant capabilities for improving student achievement. Improved accessibility, cost, and diversity of applications make integration of technology a powerful tool to compensate for executive function weaknesses and deficits and their impact on student performance, learning, and achievement. These tools can be used to compensate for decreased working memory, poor time management, poor planning and organization, poor initiation, and decreased memory. Assistive technology provides mechanisms to assist students with diverse strengths and weaknesses in mastering core curricular concepts. PMID:25010083

  7. Teachers' Perception of Their Principal's Leadership Style and the Effects on Student Achievement in Improving and Non-Improving Schools

    ERIC Educational Resources Information Center

    Hardman, Brenda Kay

    2011-01-01

    Teachers' perceptions of their school leaders influence student achievement in their schools. The extent of this influence is examined in this study. This quantitative study examined teachers' perceptions of the leadership style of their principals as transformational, transactional or passive-avoidant in improving and non-improving schools in…

  8. Integrating empowerment evaluation and quality improvement to achieve healthcare improvement outcomes

    PubMed Central

    Wandersman, Abraham; Alia, Kassandra Ann; Cook, Brittany; Ramaswamy, Rohit

    2015-01-01

    While the body of evidence-based healthcare interventions grows, the ability of health systems to deliver these interventions effectively and efficiently lags behind. Quality improvement approaches, such as the model for improvement, have demonstrated some success in healthcare but their impact has been lessened by implementation challenges. To help address these challenges, we describe the empowerment evaluation approach that has been developed by programme evaluators and a method for its application (Getting To Outcomes (GTO)). We then describe how GTO can be used to implement healthcare interventions. An illustrative healthcare quality improvement example that compares the model for improvement and the GTO method for reducing hospital admissions through improved diabetes care is described. We conclude with suggestions for integrating GTO and the model for improvement. PMID:26178332

  9. How to Know when Dramatic Change Is on Track: Leading Indicators of School Turnarounds

    ERIC Educational Resources Information Center

    Kowal, Julie; Ableidinger, Joe

    2011-01-01

    In recent years, national policymakers have placed new emphasis on "school turnarounds" as a strategy for rapid, dramatic improvement in chronically failing schools, calling on education leaders to turn around performance in the 5,000 lowest-achieving schools nationwide. This goal may seem daunting, given the dismal success rates of school…

  10. Children's Voices through Dramatic Play.

    ERIC Educational Resources Information Center

    Sierra, Zayda

    Dramatic play provides children an excellent way to express their feelings and perceptions of the world that surrounds them. It is also an alternative way for researchers and teachers to capture, understand, and interpret children's voices because of the difficulties that children have in expressing ideas through oral and written language. While…

  11. Dramatic Techniques in ESL Instruction.

    ERIC Educational Resources Information Center

    Radin, Barbara

    Three techniques have been found to be helpful in using dramatic techniques to provide motivation, self-confidence, and self-esteem to students of English as a second language at Hostos Community College. Strategic interaction is a technique based on the open-ended scenario, in which students are free to respond to the problem presented in the…

  12. Kenneth Burke's Discovery of Dramatism.

    ERIC Educational Resources Information Center

    Feehan, Michael

    1979-01-01

    Discusses how "Twelve Propositions by Kenneth Burke on the Relation between Economics and Psychology" generates a new synthesis of Marx and Freud and foreshadows Burke's system of dramatism. His conception of self, the community, and communication come together in a serious argument for drama as a model of human relations. (JMF)

  13. Learning through Dramatic Story Presentation

    ERIC Educational Resources Information Center

    Tindall, Evie

    2012-01-01

    The use of story with dramatic presentation approaches produces an engaging and powerful instructional choice for today's adult ESL educators. Two engaging and timed-tested approaches are Reader's Theater and Tableau Vivant. Both provide English language learners with content tailored to their abilities in addition to numerable opportunities to…

  14. School Improvement Plans and Student Achievement: Preliminary Evidence from the Quality and Merit Project in Italy

    ERIC Educational Resources Information Center

    Caputo, Andrea; Rastelli, Valentina

    2014-01-01

    This study provides preliminary evidence from an Italian in-service training program addressed to lower secondary school teachers which supports school improvement plans (SIPs). It aims at exploring the association between characteristics/contents of SIPs and student improvement in math achievement. Pre-post standardized tests and text analysis of…

  15. Training Theory of Mind and Executive Control: A Tool for Improving School Achievement?

    ERIC Educational Resources Information Center

    Kloo, Daniela; Perner, Josef

    2008-01-01

    In the preschool years, there are marked improvements in theory of mind (ToM) and executive functions. And, children's competence in these two core cognitive domains is associated with their academic achievement. Therefore, training ToM and executive control could be a valuable tool for improving children's success in school. This article reviews…

  16. From Compliance to Service: Evolving the State Role to Support District Data Efforts to Improve Student Achievement. Summary

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2011

    2011-01-01

    As a result of state, national and federal leadership and political will, states have dramatically increased their capacity to collect robust longitudinal education data. However, without an equally ambitious effort to ensure access and build stakeholders' capacity to use data to increase student achievement, these infrastructure investments…

  17. From Compliance to Service: Evolving the State Role to Support District Data Efforts to Improve Student Achievement

    ERIC Educational Resources Information Center

    Shah, Rebecca

    2011-01-01

    As a result of state, national and federal leadership and political will, states have dramatically increased their capacity to collect robust longitudinal education data. However, without an equally ambitious effort to ensure access and build stakeholders' capacity to use data to increase student achievement, these infrastructure investments…

  18. Effects of simulated interventions to improve school entry academic skills on socioeconomic inequalities in educational achievement.

    PubMed

    Chittleborough, Catherine R; Mittinty, Murthy N; Lawlor, Debbie A; Lynch, John W

    2014-01-01

    Randomized controlled trial evidence shows that interventions before age 5 can improve skills necessary for educational success; the effect of these interventions on socioeconomic inequalities is unknown. Using trial effect estimates, and marginal structural models with data from the Avon Longitudinal Study of Parents and Children (n = 11,764, imputed), simulated effects of plausible interventions to improve school entry academic skills on socioeconomic inequality in educational achievement at age 16 were examined. Progressive universal interventions (i.e., more intense intervention for those with greater need) to improve school entry academic skills could raise population levels of educational achievement by 5% and reduce absolute socioeconomic inequality in poor educational achievement by 15%. PMID:25327718

  19. Effects of Simulated Interventions to Improve School Entry Academic Skills on Socioeconomic Inequalities in Educational Achievement

    PubMed Central

    Chittleborough, Catherine R; Mittinty, Murthy N; Lawlor, Debbie A; Lynch, John W

    2014-01-01

    Randomized controlled trial evidence shows that interventions before age 5 can improve skills necessary for educational success; the effect of these interventions on socioeconomic inequalities is unknown. Using trial effect estimates, and marginal structural models with data from the Avon Longitudinal Study of Parents and Children (n = 11,764, imputed), simulated effects of plausible interventions to improve school entry academic skills on socioeconomic inequality in educational achievement at age 16 were examined. Progressive universal interventions (i.e., more intense intervention for those with greater need) to improve school entry academic skills could raise population levels of educational achievement by 5% and reduce absolute socioeconomic inequality in poor educational achievement by 15%. PMID:25327718

  20. The Consequences of "School Improvement": Examining the Association between Two Standardized Assessments Measuring School Improvement and Student Science Achievement

    ERIC Educational Resources Information Center

    Maltese, Adam V.; Hochbein, Craig D.

    2012-01-01

    For more than half a century concerns about the ability of American students to compete in a global workplace focused policymakers' attention on improving school performance generally, and student achievement in science, technology, engineering, and mathematics (STEM) specifically. In its most recent form--No Child Left Behind--there is evidence…

  1. Audit-based education: a potentially effective program for improving guideline achievement in CKD patients.

    PubMed

    de Goeij, Moniek C M; Rotmans, Joris I

    2013-09-01

    The achievement of treatment guidelines in patients with chronic kidney disease is poor, and more efforts are needed to improve this. Audit-based education is a program that may contribute to this improvement. de Lusignana et al. investigated whether audit-based education is effective in lowering systolic blood pressure in a primary-care setting. Although the program is inventive and promising, several adjustments are needed before it can be applied as an effective strategy. PMID:23989357

  2. The Dramatic Methods of Hans van Dam.

    ERIC Educational Resources Information Center

    van de Water, Manon

    1994-01-01

    Interprets for the American reader the untranslated dramatic methods of Hans van Dam, a leading drama theorist in the Netherlands. Discusses the functions of drama as a method, closed dramatic methods, open dramatic methods, and applying van Dam's methods. (SR)

  3. Improving Mathematics Achievement for All California Students: The Report of the California Mathematics Task Force.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento.

    This document is the result of the California Mathematics Task Force assigned to address the need to improve the mathematics achievement of California's students. Five recommendations are made and discussed: (1) The State Superintendent of Public Instruction (SSPI) must establish clear and specific content and performance standards for mathematics…

  4. Supporting Instructional Improvement in Low-Performing Schools to Increase Students' Academic Achievement

    ERIC Educational Resources Information Center

    Bellei, Cristian

    2013-01-01

    This is an impact evaluation of the Technical Support to Failing Schools Program, a Chilean compensatory program that provided 4-year in-school technical assistance to low-performing schools to improve students' academic achievement. The author implemented a quasi-experimental design by using difference-in-differences estimation combined with…

  5. Dynamic Geometry Software Improves Mathematical Achievement: Systematic Review and Meta-Analysis

    ERIC Educational Resources Information Center

    Chan, Kan Kan; Leung, Siu Wai

    2014-01-01

    Dynamic geometry software (DGS) aims to enhance mathematics education. This systematic review and meta-analysis evaluated the quasi-experimental studies on the effectiveness of DGS-based instruction in improving students' mathematical achievement. Research articles published between 1990 and 2013 were identified from major databases according to a…

  6. What Matters for Elementary Literacy Coaching? Guiding Principles for Instructional Improvement and Student Achievement

    ERIC Educational Resources Information Center

    L'Allier, Susan; Elish-Piper, Laurie; Bean, Rita M.

    2010-01-01

    Literacy coaches provide job-embedded professional development for teachers, and the number of literacy coaches in elementary schools is increasing. Although literacy coaching offers promise in terms of improving teacher practice and student achievement, guidance is needed regarding the qualifications, activities, and roles of literacy coaches.…

  7. Instructional Leadership Influence on Collective Teacher Efficacy to Improve School Achievement

    ERIC Educational Resources Information Center

    Fancera, Samuel F.; Bliss, James R.

    2011-01-01

    The purpose of this study was to examine whether instructional leadership functions, as defined in Hallinger's Principal Instructional Management Rating Scale, positively influence collective teacher efficacy to improve school achievement. Teachers from sample schools provided data for measures of collective teacher efficacy and instructional…

  8. Investing in Educator Data Literacy Improves Student Achievement. Evidence of Impact: The Oregon Data Project

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2012

    2012-01-01

    Since 2007 the Oregon DATA Project has been investing resources to provide educators on-the-job training around effective data use to improve student achievement. New evidence shows that their efforts are paying off. A 2011 Oregon DATA Project report detailed the impact of their investment in the state's educators, finding the following: (1)…

  9. Improving Student Interest and Achievement in Social Studies Using a Multiple Intelligence Approach.

    ERIC Educational Resources Information Center

    Hanley, Chris; Hermiz, Carmen; Lagioia-Peddy, Jennifer; Levine-Albuck, Valerie

    This action research paper describes a program initiated by teacher researchers to improve academic achievement and interest in social studies. The targeted group consisted of fifth graders in a lower middle class community in the Midwest. Analysis of the problem-causes data show three main factors: curriculum, attitude, and effect. In regard to…

  10. Staff Development Designed To Improve the Achievement of Students with Disabilities.

    ERIC Educational Resources Information Center

    Byrnes, MaryAnn; Majors, Martha

    This paper describes how the University of Massachusetts (Boston) developed partnership programs to improve achievement of students with significant disabilities just beginning to participate in a standards-based general curriculum. Fundamental to the effort was development of a 12-credit graduate certificate program focused on adapting the…

  11. Improving Teaching Capacity to Increase Student Achievement: The Key Role of Data Interpretation by School Leaders

    ERIC Educational Resources Information Center

    Lynch, David; Smith, Richard; Provost, Steven; Madden, Jake

    2016-01-01

    Purpose: This paper argues that in a well-organised school with strong leadership and vision coupled with a concerted effort to improve the teaching performance of each teacher, student achievement can be enhanced. The purpose of this paper is to demonstrate that while macro-effect sizes such as "whole of school" metrics are useful for…

  12. Improving High School Students' Mathematics Achievement through the Use of Motivational Strategies.

    ERIC Educational Resources Information Center

    Portal, Jamie; Sampson, Lisa

    This report describes a program for motivating students in mathematics in order to improve achievement at the high school level. The targeted population consisted of high school students in a middle class community located in a suburb of a large metropolitan area. The problems of underachievement were documented through data collected from surveys…

  13. Improving Achievement in Low-Performing Schools: Key Results for School Leaders

    ERIC Educational Resources Information Center

    Ward, Randolph E.; Burke, Mary Ann

    2004-01-01

    As accountability in schools becomes more crucial, educators are looking for comprehensive and innovative management practices that respond to challenges and realities of student academic achievement. In order to improve academic performance and the quality of instruction, the entire school community needs to be involved. This book provides six…

  14. Analyzing Academic Achievement of Junior High School Students by an Improved Rough Set Model

    ERIC Educational Resources Information Center

    Pai, Ping-Feng; Lyu, Yi-Jia; Wang, Yu-Min

    2010-01-01

    Rough set theory (RST) is an emerging technique used to deal with problems in data mining and knowledge acquisition. However, the RST approach has not been widely explored in the field of academic achievement. This investigation developed an improved RST (IMRST) model, which employs linear discriminant analysis to determine a reduct of RST, and…

  15. Does Children’s Academic Achievement Improve when Single Mothers Marry?

    PubMed Central

    Wagmiller, Robert L.; Gershoff, Elizabeth; Veliz, Philip; Clements, Margaret

    2011-01-01

    Promoting marriage, especially among low-income single mothers with children, is increasingly viewed as a promising public policy strategy for improving developmental outcomes for disadvantaged children. Previous research suggests, however, that children’s academic achievement either does not improve or declines when single mothers marry. In this paper, we argue that previous research may understate the benefits of mothers’ marriages to children from single-parent families because (1) the short-term and long-term developmental consequences of marriage are not adequately distinguished and (2) child and family contexts in which marriage is likely to confer developmental advantages are not differentiated from those that do not. Using multiple waves of data from the ECLS-K, we find that single mothers’ marriages are associated with modest but statistically significant improvements in their children’s academic achievement trajectories. However, only children from more advantaged single-parent families benefit from their mothers’ marriage. PMID:21611134

  16. Recipe for Success: An Updated Parents' Guide to Improving Colorado Schools and Student Achievement. Second Edition.

    ERIC Educational Resources Information Center

    Taher, Bonnie; Durr, Pamela

    This guide describes ways that parents can help improve student achievement and school quality. It answers such questions as how to choose the right early-education opportunity for a preschooler, how to make sure a 5-year-old is ready for school, how to help a daughter do well in school, how to work with a daughter's or son's teachers, how to help…

  17. Estimates of achievable potential for electricity efficiency improvements in U.S. residences

    SciTech Connect

    Brown, Richard

    1993-05-01

    This paper investigates the potential for public policies to achieve electricity efficiency improvements in US residences. This estimate of achievable potential builds upon a database of energy-efficient technologies developed for a previous study estimating the technical potential for electricity savings. The savings potential and cost for each efficiency measure in the database is modified to reflect the expected results of policies implemented between 1990 and 2010. Factors included in these modifications are: the market penetration of efficiency measures, the costs of administering policies, and adjustments to the technical potential measures to reflect the actual energy savings and cost experienced in the past. When all adjustment factors are considered, this study estimates that policies can achieve approximately 45% of the technical potential savings during the period from 1990 to 2010. Thus, policies can potentially avoid 18% of the annual frozen-efficiency baseline electricity consumption forecast for the year 2010. This study also investigates the uncertainty in best estimate of achievable potential by estimating two alternative scenarios -- a

  18. Modified surface loading process for achieving improved performance of the quantum dot-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Liu, Feng; Jin, Zhongxiu; Zhu, Jun; Xu, Yafeng; Zhou, Li; Dai, Songyuan

    2016-06-01

    Achieving high surface coverage of the colloidal quantum dots (QDs) on TiO2 films has been challenging for quantum dot-sensitized solar cells (QDSCs). Herein, a general surface engineering approach was proposed to increase the loading of these QDs. It was found that S2- treatment/QD re-uptake process can significantly improve the attachment of the QDs on TiO2 films. Surface concentration of the QDs was improved by ∼60%, which in turn greatly enhances light absorption and decreases carrier recombination in QDSCs. Ensuing QDSCs with optimized QD loading exhibit a power conversion efficiency of 3.66%, 83% higher than those fabricated with standard procedures.

  19. US objectives generally achieved at broadcasting satellite international conference. Improvements can help in future conferences

    NASA Astrophysics Data System (ADS)

    1984-08-01

    The implementation of broadcasting satellite service for the Western Hemisphere was planned. Broadcasting satellites transmit television programs and other information services from Earth orbit to home or office antennas. At the request of the Senate Appropriations Subcommittee on Commerce, Justice, State and the Judiciary, GAO reviewed conference results as compared to established conference objectives and examined the interagency coordination of U.S. participation in this international conference. The United States basically achieved its two most important conference objectives: adopting a technically and procedurally flexible plan for broadcasting satellite service and obtaining a sufficient allocation of satellite orbit slots and frequencies to meet domestic needs. The U.S. was unable, however, to obtain agreement on adopting a maximum signal power level for satellites. The Department of State could improve its preparation, internal coordination, and administrative support for future international conferences and recommends actions to the Secretary of State to improve its international telecommunications activities.

  20. Leveraging Improvements in Precipitation Measuring from GPM Mission to Achieve Prediction Improvements in Climate, Weather and Hydrometeorology

    NASA Technical Reports Server (NTRS)

    Smith, Eric A.

    2002-01-01

    The main scientific goal of the GPM mission, currently planned for start in the 2007 time frame, is to investigate important scientific problems arising within the context of global and regional water cycles. These problems cut across a hierarchy of scales and include climate-water cycle interactions, techniques for improving weather and climate predictions, and better methods for combining observed precipitation with hydrometeorological prediction models for applications to hazardous flood-producing storms, seasonal flood/draught conditions, and fresh water resource assessments. The GPM mission will expand the scope of precipitation measurement through the use of a constellation of some 9 satellites, one of which will be an advanced TRMM-like "core" satellite carrying a dual-frequency Ku-Ka band precipitation radar and an advanced, multifrequency passive microwave radiometer with vertical-horizontal polarization discrimination. The other constellation members will include new dedicated satellites and co-existing Operational/research satellites carrying similar (but not identical) passive microwave radiometers. The goal of the constellation is to achieve approximately 3-hour sampling at any spot on the globe. The constellation's orbit architecture will consist of a mix of sun-synchronous and non-sun-synchronous satellites with the core satellite providing measurements of cloud-precipitation microphysical processes plus calibration-quality rainrate retrievals to be used with the other retrieval information to ensure bias-free constellation coverage. GPM is organized internationally, currently involving a partnership between NASA in the US and the National Space Development Agency in Japan. Additionally, the program is actively pursuing agreements with other international partners and domestic scientific agencies and institutions, as well as participation by individual scientists from academia, government, and the private sector to fulfill mission goals and to pave

  1. A physical education trial improves adolescents' cognitive performance and academic achievement: the EDUFIT study.

    PubMed

    Ardoy, D N; Fernández-Rodríguez, J M; Jiménez-Pavón, D; Castillo, R; Ruiz, J R; Ortega, F B

    2014-02-01

    To analyze the effects of an intervention focused on increasing the time and intensity of Physical Education (PE), on adolescents' cognitive performance and academic achievement. A 4-month group-randomized controlled trial was conducted in 67 adolescents from South-East Spain, 2007. Three classes were randomly allocated into control group (CG), experimental group 1 (EG1) and experimental group 2 (EG2). CG received usual PE (two sessions/week), EG1 received four PE sessions/week and EG2 received four PE sessions/week of high intensity. Cognitive performance (non-verbal and verbal ability, abstract reasoning, spatial ability, verbal reasoning and numerical ability) was assessed by the Spanish Overall and Factorial Intelligence Test, and academic achievement by school grades. All the cognitive performance variables, except verbal reasoning, increased more in EG2 than in CG (all P < 0.05). Average school grades (e.g., mathematics) increased more in EG2 than in CG. Overall, EG2 improved more than EG1, without differences between EG1 and CG. Increased PE can benefit cognitive performance and academic achievement. This study contributes to the current knowledge by suggesting that the intensity of PE sessions might play a role in the positive effect of physical activity on cognition and academic success. Future studies involving larger sample sizes should confirm or contrast these preliminary findings. PMID:23826633

  2. Employee Perceptions of Progress with Implementing a Student-Centered Model of Institutional Improvement: An Achieving the Dream Case Study

    ERIC Educational Resources Information Center

    Cheek, Annesa LeShawn

    2011-01-01

    Achieving the Dream is a national initiative focused on helping more community college students succeed, particularly students of color and low-income students. Achieving the Dream's student-centered model of institutional improvement focuses on eliminating gaps and raising student achievement by helping institutions build a culture of evidence…

  3. Improving quality and reducing inequities: a challenge in achieving best care

    PubMed Central

    Nicewander, David A.; Qin, Huanying; Ballard, David J.

    2006-01-01

    The health care quality chasm is better described as a gulf for certain segments of the population, such as racial and ethnic minority groups, given the gap between actual care received and ideal or best care quality. The landmark Institute of Medicine report Crossing the Quality Chasm: A New Health System for the 21st Century challenges all health care organizations to pursue six major aims of health care improvement: safety, timeliness, effectiveness, efficiency, equity, and patient-centeredness. “Equity” aims to ensure that quality care is available to all and that the quality of care provided does not differ by race, ethnicity, or other personal characteristics unrelated to a patient's reason for seeking care. Baylor Health Care System is in the unique position of being able to examine the current state of equity in a typical health care delivery system and to lead the way in health equity research. Its organizational vision, “culture of quality,” and involved leadership bode well for achieving equitable best care. However, inequities in access, use, and outcomes of health care must be scrutinized; the moral, ethical, and economic issues they raise and the critical injustice they create must be remedied if this goal is to be achieved. Eliminating any observed inequities in health care must be synergistically integrated with quality improvement. Quality performance indicators currently collected and evaluated indicate that Baylor Health Care System often performs better than the national average. However, there are significant variations in care by age, gender, race/ethnicity, and socioeconomic status that indicate the many remaining challenges in achieving “best care” for all. PMID:16609733

  4. From Guide to Practice: Improving Your After School Science Program to Increase Student Academic Achievement

    NASA Astrophysics Data System (ADS)

    Taylor, J.

    2013-12-01

    Numerous science organizations, such as NASA, offer educational outreach activities geared towards after school. For some programs, the primary goal is to grow students' love of science. For others, the programs are also intended to increase academic achievement. For those programs looking to support student learning in out-of-school time environments, aligning the program with learning during the classroom day can be a challenge. The Institute for Education Sciences, What Works Clearinghouse, put together a 'Practice Guide' for maximizing learning time beyond the regular school day. These practice guides provide concrete recommendations for educators supported by research. While this guide is not specific to any content or subject-area, the recommendations provided align very well with science education. After school science is often viewed as a fun, dynamic environment for students. Indeed, one of the recommendations to ensure time is structured according to students' needs is to provide relevant and interesting experiences. Given that our after school programs provide such creative environments for students, what other components are needed to promote increased academic achievement? The recommendations provided to academic achievement, include: 1. Align Instruction, 2. Maximize Attendance and Participation, 3. Adapt Instruction, 4. Provide Engaging Experiences, and 5. Evaluate Program. In this session we will examine these five recommendations presented in the Practice Guide, discuss how these strategies align with science programs, and examine what questions each program should address in order to provide experiences that lend themselves to maximizing instruction. Roadblocks and solutions for overcoming challenges in each of the five areas will be presented. Jessica Taylor will present this research based on her role as an author on the Practice Guide, 'Improving Academic Achievement in Out-of-School Time' and her experience working in various informal science

  5. Pre-operative Thresholds for Achieving Meaningful Clinical Improvement after Arthroscopic Treatment of Femoroacetabular Impingement

    PubMed Central

    Nwachukwu, Benedict U.; Fields, Kara G.; Nawabi, Danyal H.; Kelly, Bryan T.; Ranawat, Anil S.

    2016-01-01

    sagittal CEA was the only variable maintaining significance (p = 0.032). Conclusion: We used a large prospective hip arthroscopy database to identify pre-operative patient outcome score thresholds predictive of meaningful post-operative outcome improvement after arthroscopic FAI treatment. This is the largest reported hip arthroscopy cohort to define MCID and the first to do so for iHOT-33. The HOS-ADL may have the best predictive ability for achieving MCID after hip arthroscopy. Patients with relatively high pre-operative ADL, quality of life and functional status appear to have a high chance for achieveing MCID up to our defined thresholds. Hip dysplasia is an important outcome modifier. The findings of this study may be useful for managing preoperative expectation for patients undergoing arthroscopic FAI surgery.

  6. Loop chiller plant design dramatically lowers chilled water costs

    SciTech Connect

    Hartman, T.

    1999-07-01

    Recent improvements in HVAC networking and speed control technologies, together with an improved understanding of the nature of cooling loads in buildings offer exciting opportunities for improving the energy efficiency of chiller plants. A new Loop chiller plant design has been developed that incorporates variable speed control on all plant components. Operation of this cooling plant is coordinated with the load it serves through a control network. This new approach has enormous advantages over traditional optimized plants. The two key advantages of these new Loop design chiller plants designs are: (1) Annual operating energy requirements are reduced by as much as 50% or more when compared to present state-of-the-art optimized chiller plants, and (2) A smaller sized and therefore less costly chiller plant can be designed to serve HVAC loads. The term Loop is employed to describe the technologies employed because the concept employs closed loop control by providing operational feedback from each point of use to the plant. The Loop concept also employs a single, series coupled chilled water loop for higher pumping and distribution efficiencies. This paper presents background and design theory and follows with a case study to introduce the new Loop design and operations concept. Specifics of an actual design are presented along with an explanation of how the principles can be applied economically to all new or existing chiller plant designs to achieve dramatic reductions in both construction costs and energy costs.

  7. Achievement for All: improving psychosocial outcomes for students with special educational needs and disabilities.

    PubMed

    Humphrey, Neil; Lendrum, Ann; Barlow, Alexandra; Wigelsworth, Michael; Squires, Garry

    2013-04-01

    Students with special educational needs and disabilities (SEND) are at a greatly increased risk of experiencing poor psychosocial outcomes. Developing effective interventions that address the cause of these outcomes has therefore become a major policy priority in recent years. We report on a national evaluation of the Achievement for All (AfA) programme that was designed to improve outcomes for students with SEND through: (1) academic assessment, tracking and intervention, (2) structured conversations with parents, and (3) developing provision to improve wider outcomes (e.g. positive relationships). Using a quasi-experimental, pre-test-post-test control group design, we assessed the impact of AfA on teacher ratings of the behaviour problems, positive relationships and bullying of students with SEND over an 18-month period. Participants were 4758 students with SEND drawn from 323 schools across England. Our main impact analysis demonstrated that AfA had a significant impact on all three response variables when compared to usual practice. Hierarchical linear modelling of data from the intervention group highlighted a range of school-level contextual factors and implementation activities and student-level individual differences that moderated the impact of AfA on our study outcomes. The implications of our findings are discussed, and study strengths and limitations are noted. PMID:23380579

  8. The Stories Clinicians Tell: Achieving High Reliability and Improving Patient Safety

    PubMed Central

    Cohen, Daniel L; Stewart, Kevin O

    2016-01-01

    The patient safety movement has been deeply affected by the stories patients have shared that have identified numerous opportunities for improvements in safety. These stories have identified system and/or human inefficiencies or dysfunctions, possibly even failures, often resulting in patient harm. Although patients’ stories tell us much, less commonly heard are the stories of clinicians and how their personal observations regarding the environments they work in and the circumstances and pressures under which they work may degrade patient safety and lead to harm. If the health care industry is to function like a high-reliability industry, to improve its processes and achieve the outcomes that patients rightly deserve, then leaders and managers must seek and value input from those on the front lines—both clinicians and patients. Stories from clinicians provided in this article address themes that include incident identification, disclosure and transparency, just culture, the impact of clinical workload pressures, human factors liabilities, clinicians as secondary victims, the impact of disruptive and punitive behaviors, factors affecting professional morale, and personal failings. PMID:26580146

  9. Dramatic Play in Childhood: Rehearsal for Life.

    ERIC Educational Resources Information Center

    Koste, Virginia Glasgow

    The purpose of this book is to help parents and teachers recognize and understand dramatic play in childhood as a process whereby the child acts out human experience in an attempt to order, clarify, and understand it. Written by a person experienced in theatre and drama, the book considers the following aspects of dramatic play: the importance of…

  10. Fifth Graders' Story Dramatizations during Literature Study.

    ERIC Educational Resources Information Center

    Siddall, Jeffery L.

    Dramatizations as a response activity during literature study provide a vehicle for students to use language, both verbal and nonverbal, in an educational context. A study focused on a group of five students who chose to use story dramatizations as one way to create their interpretations of the book, "The Slave Dancer" (Fox, 1973). The study,…

  11. Structuring Out-of-School Time to Improve Academic Achievement. IES Practice Guide. NCEE 2009-012

    ERIC Educational Resources Information Center

    Beckett, Megan; Borman, Geoffrey; Capizzano, Jeffrey; Parsley, Danette; Ross, Steven; Schirm, Allen; Taylor, Jessica

    2009-01-01

    Out-of-school time programs can enhance academic achievement by helping students learn outside the classroom. The purpose of this practice guide is to provide recommendations for organizing and delivering school-based out-of-school time (OST) programs to improve the academic achievement of student participants. The five recommendations in this…

  12. Improving Science Achievement and Attitudes of Students With and Without Learning Disabilities

    NASA Astrophysics Data System (ADS)

    Sanders-White, Pamela

    The primary purpose of this study was to investigate the effect of structured note-taking compared to traditional note-taking on the acquisition of scientific knowledge for students with and without learning disabilities (LD) and students with reading difficulties (RD). An additional purpose was to examine whether the two note-taking methods affected students' attitudes toward science. The sample population consisted of 203 fifth grade students across four public schools in the southern area of the United States. A standardized instrument aligned to Florida's science standards was used to measure the acquisition of scientific knowledge and the Test of Science-Related Attitudes (TOSRA) was used to measure seven distinct science-related attitudes. For meaningful analyses, students with LD and students with RD were collapsed to form a single group due to the small numbers of participants in each of the subgroups; the collapsed group was referred to as "low achievers." A three-way repeated measures ANOVA was conducted to determine the effects of the pretest-posttest Science Interim assessment by group, type of student, and gender. The pretest-posttest Science Interim assessment scores were the within-group factor, while group, type of student, and gender were the between-groups factors. Results revealed that there was a significant interaction between the pretest-posttest Science Interim assessment and group, F(1, 191) = 9.320, p = .003, indicating that scientific knowledge scores increased for the experimental group, but decreased for the control group. Results also indicated that there was a significant three-way interaction between the pretest-posttest Science Interim assessment, group, and gender, F(1, 191) = 5.197, p = .024, showing that all participants in the experimental group improved their scores; while in the control group, female scores decreased and male scores increased. Participants in the experimental and control groups did not show improved attitudes

  13. Improved single-cell culture achieved using micromolding in capillaries technology coupled with poly (HEMA)

    PubMed Central

    Ye, Fang; Jiang, Jin; Chang, Honglong; Xie, Li; Deng, Jinjun; Ma, Zhibo; Yuan, Weizheng

    2015-01-01

    Cell studies at the single-cell level are becoming more and more critical for understanding the complex biological processes. Here, we present an optimization study investigating the positioning of single cells using micromolding in capillaries technology coupled with the cytophobic biomaterial poly (2-hydroxyethyl methacrylate) (poly (HEMA)). As a cytophobic biomaterial, poly (HEMA) was used to inhibit cells, whereas the glass was used as the substrate to provide a cell adhesive background. The poly (HEMA) chemical barrier was obtained using micromolding in capillaries, and the microchannel networks used for capillarity were easily achieved by reversibly bonding the polydimethylsiloxane mold and the glass. Finally, discrete cell adhesion regions were presented on the glass surface. This method is facile and low cost, and the reagents are commercially available. We validated the cytophobic abilities of the poly (HEMA), optimized the channel parameters for higher quality and more stable poly (HEMA) patterns by investigating the effects of changing the aspect ratio and the width of the microchannel on the poly (HEMA) grid pattern, and improved the single-cell occupancy by optimizing the dimensions of the cell adhesion regions. PMID:26339307

  14. 41 CFR 102-193.25 - What type of records management business process improvements should my agency strive to achieve?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-193.25 What type of records management business process improvements should my agency strive to... management business process improvements should my agency strive to achieve? 102-193.25 Section 102-193.25... that needed records can be found rapidly to conduct agency business, to ensure that records...

  15. 41 CFR 102-193.25 - What type of records management business process improvements should my agency strive to achieve?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... management business process improvements should my agency strive to achieve? 102-193.25 Section 102-193.25...-193.25 What type of records management business process improvements should my agency strive to... of temporary records. Retention and disposal of records is governed by NARA regulations in 36...

  16. 41 CFR 102-193.25 - What type of records management business process improvements should my agency strive to achieve?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... management business process improvements should my agency strive to achieve? 102-193.25 Section 102-193.25...-193.25 What type of records management business process improvements should my agency strive to... of temporary records. Retention and disposal of records is governed by NARA regulations in 36...

  17. 41 CFR 102-193.25 - What type of records management business process improvements should my agency strive to achieve?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... management business process improvements should my agency strive to achieve? 102-193.25 Section 102-193.25...-193.25 What type of records management business process improvements should my agency strive to... of temporary records. Retention and disposal of records is governed by NARA regulations in 36...

  18. 41 CFR 102-193.25 - What type of records management business process improvements should my agency strive to achieve?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... management business process improvements should my agency strive to achieve? 102-193.25 Section 102-193.25...-193.25 What type of records management business process improvements should my agency strive to... of temporary records. Retention and disposal of records is governed by NARA regulations in 36...

  19. Using Technology To Improve Academic Achievement in Out-of-School-Time Programs in Washington, D.C.

    ERIC Educational Resources Information Center

    Liu, Meredith; Russell, Victoria; Chaplin, Duncan; Raphael, Jacqueline; Fu, Helen; Anthony, Emily

    This paper describes implementation of the federal government's DC 21st Century Community Learning Center (DC 21st CCLC) program during the summer of 2001, focusing on the use of computer technology to improve academic achievement. The DC 21st CCLC program provides funding to schools in the District of Columbia to improve their out-of-school-time…

  20. Creative Drama: More Than Story Dramatization

    ERIC Educational Resources Information Center

    Stewig, John Warren

    1977-01-01

    Suggests that creative drama, including story dramatization, must include components such as rhythmic movement, pantomime, story improvisation, minimal situations, and teaching-in-role in order to produce educational benefits from a cohesive learning sequence. (MH)

  1. What Effective Principals Do to Improve Instruction and Increase Student Achievement

    ERIC Educational Resources Information Center

    Turner, Elizabeth Anne

    2013-01-01

    The purposes of this mixed method study were to (a) Examine the relationships among principal effectiveness, principal instructional leadership, and student achievement; (b) examine the differences among principal effectiveness, principal instructional leadership and student achievement; and (c) investigate what effective principals do to improve…

  2. How Urban School Superintendents Effectively Use Data Driven Decision Making to Improve Student Achievement

    ERIC Educational Resources Information Center

    Root, Lonny Gene

    2010-01-01

    With the passage of the No Child Left Behind (NCLB) Act of 2002, schools, districts, and therefore, superintendents have been held increasingly accountable for the achievement of the students. The states and federal governments have used student achievement data to measure the progress and success of schools and districts and have held districts…

  3. Pieces of the Puzzle: Factors in Improving Achievement of Urban School Districts. Education Outlook. No. 4

    ERIC Educational Resources Information Center

    Casserly, Michael

    2012-01-01

    In one of the first large-scale analyses of urban trends on the National Assessment of Educational Progress (NAEP), the Council of the Great City Schools and the American Institutes for Research identified urban school systems that demonstrated high achievement or significant achievement gains on the NAEP, and examined possible factors behind…

  4. Improving Student Achievement: Can 9th Grade Academies Make a Difference?

    ERIC Educational Resources Information Center

    Styron, Ronald Anthony; Peasant, Eddie J.

    2010-01-01

    This study focused on student achievement in ninth grade schools or academies compared to ninth grade students enrolled in traditional high schools. Student achievement was measured by standardized test scores. Other variables tested were gender and ethnicity. All students used in this study were enrolled in the ninth grade during the 2005-2006…

  5. Developing and Improving Modified Achievement Level Descriptors: Rationale, Procedures, and Tools

    ERIC Educational Resources Information Center

    Quenemoen, Rachel; Albus, Debra; Rogers, Chris; Lazarus, Sheryl

    2010-01-01

    Some states are developing alternate assessments based on modified achievement standards (AA-MAS) to measure the academic achievement of some students with disabilities (Albus, Lazarus, Thurlow, & Cormier, 2009; Lazarus, Thurlow, Christensen, & Cormier, 2007). These assessments measure the same content as the general assessment for a given…

  6. Improving Upper Grade Math Achievement via the Integration of a Culturally Responsive Curriculum.

    ERIC Educational Resources Information Center

    Pajkos, Diane; Klein-Collins, John

    This report describes an intervention program for increasing mathematical achievement of African American students. Within the targeted population, it was evident that the disparity in math achievement between African American and White students was increasing each year. The targeted population consisted of sixth, seventh, and eighth grade…

  7. Foundations for Success: Case Studies of How Urban School Systems Improve Student Achievement [and] Abstract.

    ERIC Educational Resources Information Center

    Snipes, Jason; Doolittle, Fred; Herlihy, Corinne

    This report examines the experiences of three large urban school districts (and part of a fourth) that raised academic performance for their districts as a whole, while also reducing racial differences in achievement. Educational challenges included low achievement, political conflict, inexperienced teachers, low expectations, and lack of…

  8. Cotton domestication: Dramatic changes in a single cell

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Understanding the nature of genetic changes underpinning plant domestication is critical for untangling the evolutionary history of crops and for improving modern cultivars. A recent study in cotton provides information about the effects of domestication, showing that dramatic genome-wide changes i...

  9. Building Family and Community Demand for Dramatic Change in Schools

    ERIC Educational Resources Information Center

    Brinson, Dana; Steiner, Lucy

    2012-01-01

    District-led, dramatic change efforts in failing schools--including turnarounds and school closures--often face strong resistance from families and communities. Resistance may be based on years of tension and distrust between districts and communities, failed past school improvement efforts, or a lack of understanding about the chasm between a…

  10. Quality improvement initiatives in neonatal intensive care unit networks: achievements and challenges.

    PubMed

    Shah, Vibhuti; Warre, Ruth; Lee, Shoo K

    2013-01-01

    Neonatal intensive care unit networks that encompass regions, states, and even entire countries offer the perfect platform for implementing continuous quality improvement initiatives to advance the health care provided to vulnerable neonates. Through cycles of identification and implementation of best available evidence, benchmarking, and feedback of outcomes, combined with mutual collaborative learning through a network of providers, the performance of health care systems and neonatal outcomes can be improved. We use examples of successful neonatal networks from across North America to explore continuous quality improvement in the neonatal intensive care unit, including the rationale for the formation of neonatal networks, the role of networks in continuous quality improvement, quality improvement methods and outcomes, and barriers to and facilitators of quality improvement. PMID:24268090

  11. Does Spending More on Education Improve Academic Achievement? Backgrounder. No. 2179

    ERIC Educational Resources Information Center

    Lips, Dan; Watkins, Shanea J.; Fleming, John

    2008-01-01

    Debates about how to improve public education in America often focus on whether government should spend more on education. Federal and state policymakers proposing new education programs often base their arguments on the need to provide more resources to schools to improve opportunities for students. Many Americans seem to share this view. While…

  12. Improving Service Quality: Achieving High Performance in the Public and Private Sectors.

    ERIC Educational Resources Information Center

    Milakovich, Michael E.

    Quality-improvement principles are a sound means to respond to customer needs. However, when various quality and productivity theories and methods are applied, it is very difficult to consistently deliver quality results, especially in quasi-monopolistic, non-competitive, and regulated environments. This book focuses on quality-improvement methods…

  13. Using Weblog in Cooperative Learning to Improve the Achievement of History Learning

    ERIC Educational Resources Information Center

    Leng, Lim Hooi; Leng, Chin Hai; Abedalaziz, Nabeel

    2013-01-01

    This research investigates the use of Weblog in Cooperative Learning to enhance students' learning of History. The main issues of this study were the lack of interest and low achievement scores in History learning. The objectives of this study are to explore the incorporation of Weblog in Cooperative Learning within the teaching and learning…

  14. The Role of School Culture in Improving Student Achievement in POS

    ERIC Educational Resources Information Center

    Sundell, Kirsten; Castellano, Marisa; Overman, Laura T.; Aliaga, Oscar A.

    2012-01-01

    Over the past five years, the National Research Center for Career and Technical Education (NRCCTE) has sponsored five research studies of Programs of Study (POS)--including three ongoing longitudinal projects--with the goal of informing the field about how and under what conditions POS impact student engagement, achievement, and transition to…

  15. Improving Low Achievers' Academic Performance at University by Changing the Social Value of Mastery Goals

    ERIC Educational Resources Information Center

    Dompnier, Benoît; Darnon, Céline; Meier, Emanuele; Brandner, Catherine; Smeding, Annique; Butera, Fabrizio

    2015-01-01

    Recent research has shown that, in a university context, mastery goals are highly valued and that students may endorse these goals either because they believe in their utility (i.e., social utility), in which case mastery goals are positively linked to achievement, or to create a positive image of themselves (i.e., social desirability), in which…

  16. Can College Actions Improve the Academic Achievement of At-Risk Minority Students?

    ERIC Educational Resources Information Center

    Clagett, Craig A.

    This study examined factors affecting academic achievement of at-risk minority students to evaluate intervention strategies designed to assist such students. Data were obtained on 2,386 first-time college students entering Prince George's Community College (Maryland) in fall 1990. Factor analysis identified 10 variables that explained a…

  17. Using Culturally Competent Responsive Services to Improve Student Achievement and Behavior

    ERIC Educational Resources Information Center

    Schellenberg, Rita; Grothaus, Tim

    2011-01-01

    This article illustrates standards blending, the integration of core academic and school counseling standards, as a culturally alert responsive services strategy to assist in closing the achievement gap while also enhancing employability skills and culturally salient career competencies. The responsive services intervention described in this…

  18. Teacher Leaders at Work: Analyzing Standardized Achievement Data to Improve Instruction

    ERIC Educational Resources Information Center

    Henning, John E.

    2006-01-01

    The purpose of this study is to describe how 24 elementary and middle school teacher leaders analyzed standardized achievement test scores, utilizing four different approaches: comparing to the norm, analyzing trends, correlating data, and disaggregating data. The analyses were conducted in order to effect positive change in student learning and…

  19. Teaching Test-Taking Strategies to Improve the Academic Achievement of Students with Mild Mental Disabilities

    ERIC Educational Resources Information Center

    Kretlow, Allison G.; Lo, Ya-yu; White, Richard B.; Jordan, LuAnn

    2008-01-01

    This study examined the effects of teaching a test-taking strategy to 4 fourth- and fifth-grade students with mild mental disabilities on reading and math achievement. The intervention consisted of a direct and explicit instructional method using a mnemonic strategy. The participants' acquisition and application of the test-taking strategy on…

  20. Improving Student Achievement in Language Arts through Implementation of Multiple Intelligences Strategies.

    ERIC Educational Resources Information Center

    Geimer, Mandy; Getz, Jennifer; Pochert, Terry; Pullam, Karen

    Student achievement has been low in language arts in Suburban Chicago, Illinois school districts. This action research project was designed to determine the effect of incorporating multiple intelligence strategies into the language arts curriculum. The targeted students were in the second, third, and fifth grades, in a western suburb of Chicago,…

  1. Leveraging Quality Improvement to Achieve Student Learning Assessment Success in Higher Education

    ERIC Educational Resources Information Center

    Glenn, Nancy Gentry

    2009-01-01

    Mounting pressure for transformational change in higher education driven by technology, globalization, competition, funding shortages, and increased emphasis on accountability necessitates that universities implement reforms to demonstrate responsiveness to all stakeholders and to provide evidence of student achievement. In the face of the demand…

  2. Achievement for All: Improving Psychosocial Outcomes for Students with Special Educational Needs and Disabilities

    ERIC Educational Resources Information Center

    Humphrey, Neil; Lendrum, Ann; Barlow, Alexandra; Wigelsworth, Michael; Squires, Garry

    2013-01-01

    Students with special educational needs and disabilities (SEND) are at a greatly increased risk of experiencing poor psychosocial outcomes. Developing effective interventions that address the cause of these outcomes has therefore become a major policy priority in recent years. We report on a national evaluation of the Achievement for All (AfA)…

  3. Major Field Achievement Test in Business: Guidelines for Improved Outcome Scores--Part I

    ERIC Educational Resources Information Center

    McLaughlin, J. Patrick; White, Jason T.

    2007-01-01

    Outcomes measurements have always been an important part of proving to outside constituencies how you "measure up" to other schools with your business programs. A common nationally-normed exam that is used is the Major Field Achievement Test in Business from Educational Testing Services. Our paper discusses some guidelines that we are "pilot…

  4. Concept Mapping Strategy: An Effective Tool for Improving Students' Academic Achievement in Biology

    ERIC Educational Resources Information Center

    Sakiyo, John; Waziri, Kawu

    2015-01-01

    The study investigated the use of concept mapping teaching method on secondary school students' academic achievement in biology. Two hypotheses tested at 0.05 level of significance guided the study. The design of the study was quasi-experimental design with 122 Senior Secondary students selected purposively from two senior secondary schools in…

  5. Teacher Professional Development to Improve Science and Literacy Achievement of English Language Learners

    ERIC Educational Resources Information Center

    Lee, Okhee; Buxton, Cory A.

    2013-01-01

    The school-aged population in the United States is becoming more culturally and linguistically diverse, while achievement gaps across content areas persist. At the same time, more rigorous academic demands are being placed on all students, including English language learners (ELLs). Teachers of ELLs face the double challenge of promoting English…

  6. The Single-Gender Classroom: Improving Middle School Students' Achievement in Math

    ERIC Educational Resources Information Center

    Whalen, William V., III.

    2012-01-01

    At Joseph Case Junior High School, a school located in Swansea, Massachusetts for students in grades six through eight; there was a problematic trend in regard to student achievement in mathematics. Upon completion of an analysis of student cohort results in mathematics on the MCAS (Massachusetts Comprehensive Assessment System), there was an…

  7. Does NCLB Improve the Achievement of Students with Disabilities? A Regression Discontinuity Design

    ERIC Educational Resources Information Center

    Wei, Xin

    2012-01-01

    The No Child Left Behind Act (NCLB) holds public schools accountable for the academic achievement of student subgroups that are larger than the state minimum-subgroup-size threshold. In 2004, California added students with disabilities to the NCLB subgroup categories. Using a regression discontinuity design, this study compared the academic…

  8. Using Self-Correction to Improve the Spelling Performance of Low-Achieving Third Graders.

    ERIC Educational Resources Information Center

    Wirtz, Connie L.; And Others

    1996-01-01

    Comparison of two spelling strategies (traditional versus self-correction) on spelling performance of six low-achieving third-grade students found the self-correction procedure more effective than the traditional condition and also helped students maintain their ability to correctly spell previously learned words. (Author/DB)

  9. Traditional Teaching Strategies versus Cooperative Teaching Strategies: Which Can Improve Achievement Scores in Chinese Middle Schools?

    ERIC Educational Resources Information Center

    Messier, William P.

    2005-01-01

    This study examines two teaching styles in Chinese middle schools, traditional lecture-based and cooperative learning. The study uses simple descriptive statistics to analyze economic status and achievement scores for both strategies in four Chinese middle schools. There were 145 randomly selected middle school students involved in the study. The…

  10. Comparing District Achievement to Improve Decision Making in Clark County, Nevada. Vignette

    ERIC Educational Resources Information Center

    American Institutes for Research, 2012

    2012-01-01

    In response to changing demographics, a tightening budget, and drastic achievement gaps (white students outperform Latino students on standardized tests) the Clark County School District in Nevada (the fifth largest district in the country) commissioned, in 2011, an educational and operational efficiency review. The district commissioned the…

  11. Closing the Achievement Gap: Principles for Improving the Educational Success of All Students. ERIC Digest.

    ERIC Educational Resources Information Center

    Schwartz, Wendy

    This digest reviews educational policies and practices that have been proven effective in closing the achievement gap, offering a list of resources with detailed information about them. The digest focuses on state and district roles (e.g., developing and implementing educational goals, rigorous standards, and accountability standards and providing…

  12. Improving Parental Involvement and Reading Achievement of Caribbean Immigrant Adolescents through Differentiated Instruction

    ERIC Educational Resources Information Center

    Robert, Joshua

    2010-01-01

    The purpose of this applied dissertation study was to determine the relative impact of parental involvement, parental school perception, student generation status, and Caribbean adolescents' own attitudes and behavior towards academic achievement and reading comprehension skills. For this study, 45 Caribbean parents from Grenadian, Guyanese,…

  13. Effectiveness of a Metacognitive Reading Strategies Program for Improving Low Achieving EFL Readers

    ERIC Educational Resources Information Center

    Ismail, Nasrah Mahmoud; Tawalbeh, Tha'er Issa

    2015-01-01

    As the training of language learners was a main concern of EFL teachers, this study aimed to assess the effectiveness of metacognitive reading strategies instruction (MRSI) on Taif University EFL students who achieved low results in reading. The final sample of this study was (21) female university students. The sample was divided into two groups;…

  14. Is There a Relationship between the Play Attention Program and Improved Student Achievement?

    ERIC Educational Resources Information Center

    Webber, Jenny Ann

    2011-01-01

    Attention Deficit/Hyperactivity Disorder (ADHD) and its effects on student academic achievement have been researched for many years. There have been many interventions that have been used in treating ADHD that have been found successful when implemented consistently. Some of the interventions that have been researched in the past are behavior…

  15. Improving Elementary American Indian Students' Math Achievement with Inquiry-Based Mathematics and Games

    ERIC Educational Resources Information Center

    Stone, Jamalee; Hamann, Edmund

    2012-01-01

    Project Inquiry-Based Mathematics was a National Science Foundation Math-Science Partnership implemented in a Great Plains city school district with a significant K-12 Native American population. One goal of the project was to reduce the achievement gap between Native American and non-Native students enrolled in district. This gap reduction was to…

  16. Improving Astronomy Achievement and Attitude through Astronomy Summer Project: A Design, Implementation and Assessment

    ERIC Educational Resources Information Center

    Türk, Cumhur; Kalkan, Hüseyin; Iskeleli', Nazan Ocak; Kiroglu, Kasim

    2016-01-01

    The purpose of this study is to examine the effects of an astronomy summer project implemented in different learning activities on elementary school students, pre-service elementary teachers and in-service teachers' astronomy achievement and their attitudes to astronomy field. This study is the result of a five-day, three-stage, science school,…

  17. The Effect of Using Activities Improving Scientific Literacy on Students' Achievement in Science and Technology Lesson

    ERIC Educational Resources Information Center

    Gucluer, Efe; Kesercioglu, Teoman

    2012-01-01

    The aim of this study is examining the effect of the using scientific literacy development activities on students' achievement. The study was carried out in a primary school in Buca Izmir for 2010-2011 academic years. System of our body was chosen as a study topic in our search which took 6 weeks. Pre-post test semi experimental control model was…

  18. Turnaround Schools: Practices Used by Nationally Recognized Principals to Improve Student Achievement in High Poverty Schools

    ERIC Educational Resources Information Center

    Brown, Angela Antuanette

    2012-01-01

    The specific purpose of this study was to identify the practices used by leaders of National Blue Ribbon Awarded Schools to successfully turnaround a school or to maintain proficient achievement scores within the school. The school principals answered a four part questionnaire for this study. Part 1 of the questionnaire asked about the extent to…

  19. A Mobile Gamification Learning System for Improving the Learning Motivation and Achievements

    ERIC Educational Resources Information Center

    Su, C-H.; Cheng, C-H.

    2015-01-01

    This paper aims to investigate how a gamified learning approach influences science learning, achievement and motivation, through a context-aware mobile learning environment, and explains the effects on motivation and student learning. A series of gamified learning activities, based on MGLS (Mobile Gamification Learning System), was developed and…

  20. 78 FR 69336 - Title I-Improving the Academic Achievement of the Disadvantaged

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... FR 52467) a notice of proposed rulemaking regarding modified academic achievement standards and... period for seven days. DATES: For the proposed rule published on August 23, 2013 (78 FR 52467), written... August 23, 2013, we published a notice of proposed rulemaking in the Federal Register (78 FR...

  1. Programming in Pairs with Alice to Improve Confidence, Enjoyment, and Achievement

    ERIC Educational Resources Information Center

    Bishop-Clark, Cathy; Courte, Jill; Howard, Elizabeth V.

    2006-01-01

    Students in an introductory computing class participated in a study investigating the impact of using a graphics programming environment (Alice) and pair-programming on confidence, enjoyment and achievement. Sixty-four participants completed a short questionnaire and a content pre-test about computer programming concepts. Students were then…

  2. Waste Minimization Improvements Achieved Through Six Sigma Analysis Result In Significant Cost Savings

    SciTech Connect

    Mousseau, Jeffrey, D.; Jansen, John, R.; Janke, David, H.; Plowman, Catherine, M.

    2003-02-26

    Improved waste minimization practices at the Department of Energy's (DOE) Idaho National Engineering and Environmental Laboratory (INEEL) are leading to a 15% reduction in the generation of hazardous and radioactive waste. Bechtel, BWXT Idaho, LLC (BBWI), the prime management and operations contractor at the INEEL, applied the Six Sigma improvement process to the INEEL Waste Minimization Program to review existing processes and define opportunities for improvement. Our Six Sigma analysis team: composed of an executive champion, process owner, a black belt and yellow belt, and technical and business team members used this statistical based process approach to analyze work processes and produced ten recommendations for improvement. Recommendations ranged from waste generator financial accountability for newly generated waste to enhanced employee recognition programs for waste minimization efforts. These improvements have now been implemented to reduce waste generation rates and are producing positive results.

  3. Dramatizing Poetry in the Second Language Classroom

    ERIC Educational Resources Information Center

    Elting, Stephen; Firkins, Arthur

    2006-01-01

    Poetry performance is an approach to learning where students can use theatrical techniques to develop a response to the poem. This paper argues that ELL students can explore the aesthetic function of language and, more widely, develop confidence in using English as a communicative tool through the dramatization of poetry. We describe the process…

  4. Nietzsche contra Burke: The Melodrama in Dramatism.

    ERIC Educational Resources Information Center

    Desilet, Gregory

    1989-01-01

    Examines Kenneth Burke's and Friedrich Nietzsche's similar understanding of the hortatory nature of language-using, weighed against their radically differing conceptions of the negative, which allows a distinction between two genres of dramatism, and illustrates contrasting orientations toward symbolic activity in general. (SR)

  5. The Psychodrama-Social Dramatics Separation.

    ERIC Educational Resources Information Center

    Klepac, Richard L.

    Social dramatics is a therapeutic and educational program that can act as a mirror to reflect images of the self in action with others. It is the modality for experiential learning to correct social dysfunction by providing models for imitation, opportunities to practice and develop individual forms from that model, and risk free environments for…

  6. Introductory Dramatics Guide for Grade 9. (Revised).

    ERIC Educational Resources Information Center

    Montgomery County Board of Education, Rockville, MD.

    Based on the experiences of classroom teachers of theatre, the elective dramatics course described in this guide is designed to enhance ninth grade students' aesthetic awareness, social development, intellectual growth, and technical knowledge. Following a brief course description and overview, the guide presents complete instructions for seven…

  7. Dramatic Ways to Engage Every Student

    ERIC Educational Resources Information Center

    Dixon, Edmond J.

    2012-01-01

    The goal of all teaching should be to help students make neural connections--the basis for all learning. To do that, however, the student has to have engagement and cognition around the material to be learned. At its core, dramatic activities, even when they have nothing to do with performance, have a tremendous ability to foster these…

  8. Back to Basics through Creative Dramatics.

    ERIC Educational Resources Information Center

    Rubin, Janet E.

    In the back to basics era, creative dramatics should still be used in the English classroom because it helps to develop the entire child. For some time, teaching strategies have been directed at the left brain, the hemisphere that deals with logical and linear functions. Recently, however, attention has been given to the right side of the brain,…

  9. Reading in Upward Bound: An Evaluation of a Reading Improvement Course and an Analysis of Some Correlates of Reading Achievement.

    ERIC Educational Resources Information Center

    Gwaltney, Wayne Keith

    The purpose of this study was to evaluate a seven-week reading improvement course for Upward Bound students and to analyze select correlates of reading achievement. Sixty Upward Bound students attending a summer session at Murray State University in Murray, Kentucky, served as the sample. The subjects were randomly assigned to an experimental…

  10. Improving Learning Achievements, Motivations and Problem-Solving Skills through a Peer Assessment-Based Game Development Approach

    ERIC Educational Resources Information Center

    Hwang, Gwo-Jen; Hung, Chun-Ming; Chen, Nian-Shing

    2014-01-01

    In this study, a peer assessment-based game development approach is proposed for improving students' learning achievements, motivations and problem-solving skills. An experiment has been conducted to evaluate the effectiveness of the proposed approach in a science course at an elementary school. A total of 167 sixth graders participated in…

  11. Improving Science, Technology and Mathematics Students' Achievement: Imperatives for Teacher Preparation in the Caribbean Colleges and Universities

    ERIC Educational Resources Information Center

    Ogunkola, Babalola J.

    2012-01-01

    The concerns of this article are the unacceptable status of Science, Technology and Mathematics (STM) Education in the Caribbean and how to improve the students' achievement in the subjects involved through the instrumentality of better preparation of teachers by the Colleges and University faculties training teachers in the region. The index for…

  12. An Investigation of World Language Teachers' Use of Student Performance Data to Inform Teaching and to Help Improve Student Achievement

    ERIC Educational Resources Information Center

    Koffi, Bruno N.

    2013-01-01

    This qualitative study investigated the types of content-based student performance data World Language teachers used to improve instruction and student academic achievement, the purposes for which they used data, the issues they encountered, and the suggestions they made for more effective use of data. The Standards for Foreign Language Learning…

  13. Experimental Evaluations of Two Strategies to Improve Reading Achievement in Kenya: Enhanced Literacy Instruction and Treatment of Malaria

    ERIC Educational Resources Information Center

    Jukes, Matthew; Dubeck, Margaret; Brooker, Simon; Wolf, Sharon

    2012-01-01

    There is less quality evidence on how malaria may affect cognitive abilities and educational achievement or on how schools can tackle the problem of malaria among school children. A randomised trial among Sri Lankan children showed that weekly malaria chemoprophylaxis with chloroquine can improve school examination scores. The Health and Literacy…

  14. GUIDELINES FOR INDUSTRIAL BOILER PERFORMANCE IMPROVEMENT. (BOILER ADJUSTMENT PROCEDURES TO MINIMIZE AIR POLLUTION AND TO ACHIEVE EFFICIENT USE OF FUEL)

    EPA Science Inventory

    Recommended procedures for improving industrial boiler performance to minimize air pollution and to achieve efficient use of fuel are given. It is intended for use by industrial boiler operators to perform an efficiency and emissions tune-up on boilers firing gas, oil, or coal. P...

  15. A University Engagement Model for Achieving Technology Adoption and Performance Improvement Impacts in Healthcare, Manufacturing, and Government

    ERIC Educational Resources Information Center

    McKinnis, David R.; Sloan, Mary Anne; Snow, L. David; Garimella, Suresh V.

    2014-01-01

    The Purdue Technical Assistance Program (TAP) offers a model of university engagement and service that is achieving technology adoption and performance improvement impacts in healthcare, manufacturing, government, and other sectors. The TAP model focuses on understanding and meeting the changing and challenging needs of those served, always…

  16. Improving Achievement in Secondary Schools: Impact of a Literacy Project on Reading Comprehension and Secondary School Qualifications

    ERIC Educational Resources Information Center

    Lai, Mei Kuin; Wilson, Aaron; McNaughton, Stuart; Hsiao, Selena

    2014-01-01

    This paper examines whether a literacy intervention involving generic and content area literacy components can improve both achievement on a standardized reading test and the attainment of secondary school qualifications, and whether the intervention can be implemented by teachers in their regular classroom settings. We report on a design-based…

  17. Top 10 Ways to Improve Science Achievement: Actions for School Principals, Assistant Principals, Department Chairs and School Improvement Consultants.

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2007

    2007-01-01

    High Schools That Work (HSTW) Assessment data show the need to improve science education in both the middle grades and high school. Science education increases students' critical thinking and problem-solving skills. This publication is designed to help principals, other school leaders and teachers identify rigorous instruction and successfully…

  18. Emerging Evidence on Improving High School Student Achievement and Graduation Rates: The Effects of Four Popular Improvement Programs. Issue Brief

    ERIC Educational Resources Information Center

    Herlihy, Corinne M.; Quint, Janet

    2006-01-01

    The National High School Center released methods for improving low-performing high schools based on some of the most rigorous research currently available in the school reform arena. This research brief identifies lessons learned as well as key practices used to strengthen high schools and is based on evaluations of four widely used high school…

  19. Evaluation and capacity building to improve precollege science and mathematics achievement in the US: 10 CFR, Part 605

    SciTech Connect

    Not Available

    1992-01-01

    The National Center for Improving Science Education has undertaken activities to achieve evaluation goals for DOE's Precollege programs: develop means to determine program quality; develop means for determining the contribution of DOE precollege programs to both teacher enhancement and student achievement; provide evaluation designs and instruments and reports of program quality and impact; and strengthen both DOE's and the Labs' capacity to do both short- and long-term planning as well as deliver effective programs and evaluation. Appendices include evaluation/technical assistance report, profiling teacher research participation and teacher development programs, teacher surveys, impact assessment design, and teacher research participation programs anecdotes for 8 labs.

  20. Creating a Longitudinal Data System: Using Data To Improve Student Achievement

    ERIC Educational Resources Information Center

    Achieve, Inc., 2006

    2006-01-01

    Policymakers and educators need longitudinal data systems capable of providing timely, valid and relevant data. Access to these data gives teachers the information they need to tailor instruction to help each student improve, gives administrators the resources and information to effectively and efficiently manage, and enables policymakers to…

  1. Resource Allocation Practices in Three Charter Middle Schools in Relation to Student Achievement Improvement Strategies

    ERIC Educational Resources Information Center

    Campo-Contreras, Susana

    2013-01-01

    The purpose of the study was to develop a better understanding of the allocation of resources used to improve student learning outcomes in three middle schools within a Charter Management Organization (CMO). The three middle schools that participated in the study have similar demographics and serve students in low socio-economic areas of Los…

  2. An Individualized Approach To Improve Reading Achievement Levels and Behavior of Learning Disabled Pupils.

    ERIC Educational Resources Information Center

    Hebron, Preston T., Jr.

    In this practicum, 15 learning-disabled pupils in grades two and three participated in an individualized program featuring mastery learning, a personalized system of instruction, attention to learning style and modality, and behavior modification, in order to improve reading levels and poor behavior. Program components included learning stations,…

  3. What Is the Best Way to Achieve Broader Reach of Improved Practices in Higher Education?

    ERIC Educational Resources Information Center

    Kezar, Adrianna

    2011-01-01

    This article examines a common problem in higher education--how to create more widespread use of improved practices, often commonly referred to as innovations. I argue that policy models of scale-up are often advocated in higher education but that they have a dubious history in community development and K-12 education and that higher education…

  4. Creating Birds of Similar Feathers: Leveraging Similarity to Improve Teacher-Student Relationships and Academic Achievement

    ERIC Educational Resources Information Center

    Gehlbach, Hunter; Brinkworth, Maureen E.; King, Aaron M.; Hsu, Laura M.; McIntyre, Joseph; Rogers, Todd

    2016-01-01

    When people perceive themselves as similar to others, greater liking and closer relationships typically result. In the first randomized field experiment that leverages actual similarities to improve real-world relationships, we examined the affiliations between 315 9th grade students and their 25 teachers. Students in the treatment condition…

  5. Achieving World-Class Schools: Mastering School Improvement Using a Genetic Model.

    ERIC Educational Resources Information Center

    Kimmelman, Paul L.; Kroeze, David J.

    In providing its program for education reform, this book uses, as an analogy, the genetic model taken from the Human Genome project. In the first part, "Theoretical Underpinnings," the book explains why a genetic model can be used to improve school systems; describes the critical components of a world-class school system; and details the genetic…

  6. Effects of Simulated Interventions to Improve School Entry Academic Skills on Socioeconomic Inequalities in Educational Achievement

    ERIC Educational Resources Information Center

    Chittleborough, Catherine R.; Mittinty, Murthy N.; Lawlor, Debbie A.; Lynch, John W.

    2014-01-01

    Randomized controlled trial evidence shows that interventions before age 5 can improve skills necessary for educational success; the effect of these interventions on socioeconomic inequalities is unknown. Using trial effect estimates, and marginal structural models with data from the Avon Longitudinal Study of Parents and Children (n = 11,764,…

  7. Improving Student Achievement in Introductory Computer Science Courses Using Peer-Led Team Learning

    ERIC Educational Resources Information Center

    Dennis, Sonya Maria

    2013-01-01

    There has been a steady decline of majors in the disciplines of science, technology, engineering, and mathematics ("STEM majors"). In an effort to improve recruitment and retention in "STEM" majors, an active-learning methodology--"peer-led team learning" ("PLTL")--was implemented by the participating…

  8. Increasing Student Achievement and Improving Self-Esteem through a Community Building Intervention

    ERIC Educational Resources Information Center

    Lupo, Concetta M.

    2012-01-01

    This study focused on improving students' self-esteem through community building at an elementary school in a low socioeconomic community where over 55% of the students live below the poverty line. Orefield and Yun state in their 1999 article, "Resegregation of America's schools," "school level poverty is related to many…

  9. Evaluating and Improving Student Achievement in Business Programs: The Effective Use of Standardized Assessment Tests

    ERIC Educational Resources Information Center

    Black, H. Tyrone; Duhon, David L.

    2003-01-01

    Having made "continuous improvement" the theme of its accreditation process a decade ago, the Association to Advance Collegiate Schools of Business (AACSB) is poised to make "assurance of learning" the current focus of the faculty/student exchange. In this article, the authors discuss how to use standardized assessment tests appropriately and…

  10. Combined Fluency and Cognitive Strategies Instruction Improves Mathematics Achievement in Early Elementary School

    ERIC Educational Resources Information Center

    Carr, Martha; Taasoobshirazi, Gita; Stroud, Rena; Royer, James M.

    2011-01-01

    One hundred and seventy-eight second grade students from two states (Georgia and Massachusetts) participated in an experiment in which they were randomly assigned to either (1) a computer program designed to increase fluency in addition and subtraction, (2) a program designed to improve cognitive strategy use for addition and subtraction, (3) a…

  11. Improving Student Achievement in Alaska. Alaska Goals 2000 Annual Report, 1997-98.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau.

    Alaska Goals 2000 is part of a coordinated, statewide effort to improve public education for all students in Alaska. In 1997-1998, 90% of Alaska's federal funding was used to fund grants to local school districts, and 10% was used to fund state-level activities through the Alaska Department of Education. During 1997-1998, curriculum frameworks and…

  12. School Stability: Improving Academic Achievement for NJ Foster Children. Policy Brief

    ERIC Educational Resources Information Center

    Bernard-Rance, Kourtney; Parello, Nancy

    2014-01-01

    Children in New Jersey's foster care system are more likely to remain in their home school when they enter foster care, thanks to a law passed in 2010, giving these fragile children improved educational stability. The law allows children to remain in their "school of origin" when they are placed in foster care, even if the foster…

  13. What We Know about Student Achievement and School Improvement in Kansas. Focus On...

    ERIC Educational Resources Information Center

    Tallman, Mark

    2012-01-01

    Educational improvement can be measured over time and against benchmarks in four key areas: (1) mastery of basic reading and math skills; (2) high school completion; (3) preparation for postsecondary education; and (4) adult educational attainment. The first three reflect how the school system prepares students for postsecondary education. The…

  14. Teachers Unions and Management Partnerships: How Working Together Improves Student Achievement

    ERIC Educational Resources Information Center

    Rubinstein, Saul A.; McCarthy, John E.

    2014-01-01

    For more than a decade, the debate over public school reform has created friction between teachers unions, administrators, school boards, parents, policymakers, and other stakeholders in public education and has fueled disagreements over how to improve the quality of teaching and learning for children. While many factors make consensus elusive…

  15. Using Motivational Strategies To Improve Academic Achievement of Middle School Students.

    ERIC Educational Resources Information Center

    DeKeyrel, Angela; Dernovish, Julie; Epperly, Annette; McKay, Victoria

    This action research project sought to improve student motivation in order to increase academic performance among eighth graders in an urban community. Evidence of academic underachievement and lack of student participation was documented by means of teacher observations, incomplete and missing assignments, and student questionnaires. Student,…

  16. Leaders of Learning: How District, School, and Classroom Leaders Improve Student Achievement

    ERIC Educational Resources Information Center

    DuFour, Richard; Marzano, Robert J.

    2011-01-01

    In their first coauthored book, Dr. DuFour and Dr. Marzano have combined their passions to articulate how effective leaders foster continuous improvement at the district, school, and classroom levels. The book focuses on district leadership, principal leadership, and team leadership and addresses how individual teachers can be most effective in…

  17. Effective Strategies That Urban Superintendents Use That Improve the Academic Achievement for African-American Males

    ERIC Educational Resources Information Center

    Shackelford, Cardenas

    2013-01-01

    The roles of urban superintendents are crucial to improving the educational outlook for the neediest students, specifically the African-American males. The roles and responsibilities of the urban school superintendent today are more numerous, complex, and demanding than in the past. The expectations of today's urban superintendents are to be…

  18. Improving Reading Achievement of First Grade Students by Integrating Phonics Skills into a Whole Language Curriculum.

    ERIC Educational Resources Information Center

    Batjes, Kathy; Brown, Theresa

    An action research study implemented a program for improving the reading ability of first-grade students who enter school with low reading readiness skills. The targeted population came from a mid-size, middle-class town in northern Illinois that has experienced recent growth and socioeconomic changes. The problem was evidenced by teacher…

  19. Teacher Self-Evaluation of Renewal Efforts of Their Teaching Practices To Improve Student Achievement.

    ERIC Educational Resources Information Center

    Fountain, Cheryl; Drummond, Robert J.; Senterfitt, Heather D.

    This study evaluated how teachers perceived their efforts to improve their teaching practices by participating in the Jacksonville Urban Educational Partnership (JUEP), a Professional Development School (PDS). The JUEP was designed to create sustained, high quality, professional development systems for inservice educators in three PDSs. The study…

  20. Techniques for mass resolution improvement achieved by typical plasma mass analyzers: Modeling and simulations

    NASA Astrophysics Data System (ADS)

    Nicolaou, Georgios; Yamauchi, Masatoshi; Wieser, Martin; Barabash, Stas; Fedorov, Andrei

    2016-04-01

    Mass separation and particularly distinction between atomic ions and molecular ions are essential in understanding a wide range of plasma environments, with each consisted of different species with various properties. In this study we present the optimization results of light-weight (about 2 kg) magnetic mass analyzers with high g-factor for Rosetta (Ion Composition Analyser: ICA) and for Mars Express and Venus Express (Ion Mass Analyser: IMA). For the instrument's optimization we use SIMION, a 3D ion tracing software in which we can trace particle beams of several energies and directions, passing through the instrument's units. We first reproduced ICA and IMA results, which turned out to be different from simple models for low energy (< 100 eV). We then change the mechanical structure of several units of the instrument and we quantify the new mass resolution achieved with each change. Our goal is to find the optimal instrument's structure, which will allow us to achieve a proper mass resolution to distinguish atomic nitrogen from atomic oxygen for the purposes of a future magnetospheric mission.

  1. Sectionalizing interconnected transmission network to improve system performance and achieve fault current reduction

    SciTech Connect

    Ray, B.

    1998-12-31

    An analysis was recently undertaken at Northern States Power Company (NSP) in an attempt to identify the advantages and disadvantages of sectionalizing Twin Cities metropolitan area transmission system. Five specific sectionalization schemes were developed to evaluate the transmission system performance associated with each scenario. These schemes were judged against the following performance characteristics: fault current level, severity of voltage depression during faults, NSP system losses, system through flow and contingency operation. Study results indicated that by careful application of the splitting scheme, sectionalization can provide significant performance improvements and still have economic feasibility. A comparison between sectionalization costs (increased system losses) and its benefits (improved performance) would help determine to what degree sectionalization is economically feasible and make the final decision. Of the five schemes tested, the contour that appeared the best in terms of reliability, performance and economics was chosen for implementation in NSP system during 1997 summer.

  2. Improving University Ranking to Achieve University Competitiveness by Management Information System

    NASA Astrophysics Data System (ADS)

    Dachyar, M.; Dewi, F.

    2015-05-01

    One way to increase university competitiveness is through information system management. A literature review was done to find information system factors that affect university performance in Quacquarelli Symonds (QS) University Ranking: Asia evaluation. Information system factors were then eliminated using Delphi method through consensus of 7 experts. Result from Delphi method was used as measured variables in PLS-SEM. Estimation with PLS-SEM method through 72 respondents shows that the latent variable academic reputation and citation per paper have significant correlation to university competitiveness. In University of Indonesia (UI) the priority to increase university competitiveness as follow: (i) network building in international conference, (ii) availability of research data to public, (iii) international conference information, (iv) information on achievements and accreditations of each major, (v) ease of employment for alumni.

  3. Identification of Energy Efficiency Opportunities through Building Data Analysis and Achieving Energy Savings through Improved Controls

    SciTech Connect

    Katipamula, Srinivas; Taasevigen, Danny J.; Koran, Bill

    2014-09-04

    This chapter will highlight analysis techniques to identify energy efficiency opportunities to improve operations and controls. A free tool, Energy Charting and Metrics (ECAM), will be used to assist in the analysis of whole-building, sub-metered, and/or data from the building automation system (BAS). Appendix A describes the features of ECAM in more depth, and also provide instructions for downloading ECAM and all resources pertaining to using ECAM.

  4. Live births achieved via IVF are increased by improvements in air quality and laboratory environment

    PubMed Central

    Heitmann, Ryan J; Hill, Micah J; James, Aidita N; Schimmel, Tim; Segars, James H; Csokmay, John M; Cohen, Jacques; Payson, Mark D

    2016-01-01

    Infertility is a common disease, which causes many couples to seek treatment with assisted reproduction techniques. Many factors contribute to successful assisted reproduction technique outcomes. One important factor is laboratory environment and air quality. Our facility had the unique opportunity to compare consecutively used, but separate assisted reproduction technique laboratories, as a result of a required move. Environmental conditions were improved by strategic engineering designs. All other aspects of the IVF laboratory, including equipment, physicians, embryologists, nursing staff and protocols, were kept constant between facilities. Air quality testing showed improved air quality at the new IVF site. Embryo implantation (32.4% versus 24.3%; P < 0.01) and live birth (39.3% versus 31.8%, P < 0.05) were significantly increased in the new facility compared with the old facility. More patients met clinical criteria and underwent mandatory single embryo transfer on day 5 leading to both a reduction in multiple gestation pregnancies and increased numbers of vitrified embryos per patient with supernumerary embryos available. Improvements in IVF laboratory conditions and air quality had profound positive effects on laboratory measures and patient outcomes. This study further strengthens the importance of the laboratory environment and air quality in the success of an IVF programme. PMID:26194882

  5. Achieving health, safety, and performance improvements through enhanced cost visibility and workplace partnerships.

    PubMed

    Grant, Katharyn A; Garland, John G; Joachim, Todd C; Wallen, Andrew; Vital, Twyla

    2003-01-01

    Reduction in the environment, safety, and occupational health (ESOH) component of operational costs requires not only a better understanding of ESOH costs and requirements, but also the formation of effective partnerships between ESOH professionals, financial analysts, and shop workers to identify viable improvements to current practices. This article presents two case studies of efforts to enhance productivity and ESOH in corrosion control facilities at Randolph Air Force Base (AFB), Texas, and Robins AFB, Ga. At each site, activity-based cost models were created to increase the visibility of ESOH-related costs and target improvement opportunities. Analysis of the strip-and-paint processes for the T-38 aircraft at Randolph and the F-15 radome and C-141 aft cowl at Robins revealed that a large proportion of operating costs were tied to ESOH requirements and practices (22 and 39%, respectively). In each case ESOH professionals teamed with shop personnel to identify potential improvements in personal protective equipment use, waste disposal, tool selection, and work methods. This approach yielded alternatives projected to reduce total shop costs by 5 to 7%. This case study demonstrates how workplaces can identify cost-saving and efficiency-enhancing practices by partnering with ESOH professionals in planning and decision-making activities. PMID:14521429

  6. Achieving Exceptional Grain Refinement through Severe Plastic Deformation: New Approaches for Improving the Processing Technology

    NASA Astrophysics Data System (ADS)

    Valiev, Ruslan Z.; Langdon, Terence G.

    2011-10-01

    The processes of equal-channel angular pressing (ECAP) and high-pressure torsion (HPT) are now established for the fabrication of ultrafine-grained metals having superior properties by comparison with their coarse-grained counterparts. This article examines the recent developments designed to improve the processing technology of ECAP and HPT and to establish these techniques as viable procedures for use in industrial applications. Based on these developments, it is reasonable to anticipate these processing procedures will experience increasing use in the fabrication of commercial products.

  7. Clinical decision support systems for improving diagnostic accuracy and achieving precision medicine.

    PubMed

    Castaneda, Christian; Nalley, Kip; Mannion, Ciaran; Bhattacharyya, Pritish; Blake, Patrick; Pecora, Andrew; Goy, Andre; Suh, K Stephen

    2015-01-01

    As research laboratories and clinics collaborate to achieve precision medicine, both communities are required to understand mandated electronic health/medical record (EHR/EMR) initiatives that will be fully implemented in all clinics in the United States by 2015. Stakeholders will need to evaluate current record keeping practices and optimize and standardize methodologies to capture nearly all information in digital format. Collaborative efforts from academic and industry sectors are crucial to achieving higher efficacy in patient care while minimizing costs. Currently existing digitized data and information are present in multiple formats and are largely unstructured. In the absence of a universally accepted management system, departments and institutions continue to generate silos of information. As a result, invaluable and newly discovered knowledge is difficult to access. To accelerate biomedical research and reduce healthcare costs, clinical and bioinformatics systems must employ common data elements to create structured annotation forms enabling laboratories and clinics to capture sharable data in real time. Conversion of these datasets to knowable information should be a routine institutionalized process. New scientific knowledge and clinical discoveries can be shared via integrated knowledge environments defined by flexible data models and extensive use of standards, ontologies, vocabularies, and thesauri. In the clinical setting, aggregated knowledge must be displayed in user-friendly formats so that physicians, non-technical laboratory personnel, nurses, data/research coordinators, and end-users can enter data, access information, and understand the output. The effort to connect astronomical numbers of data points, including '-omics'-based molecular data, individual genome sequences, experimental data, patient clinical phenotypes, and follow-up data is a monumental task. Roadblocks to this vision of integration and interoperability include ethical, legal

  8. Achieving crop stress tolerance and improvement--an overview of genomic techniques.

    PubMed

    Rasool, Saiema; Ahmad, Parvaiz; Rehman, Muneeb U; Arif, Ahmad; Anjum, Naser A

    2015-12-01

    The inexorable exposure of plants to the combinations of abiotic stresses has affected the worldwide food supply. The crop improvement against these abiotic stresses has been captivating approach to increase the yield and enhance the stress tolerance. By using traditional and modern breeding methods, the characters that confer tolerance to these stresses were accomplished. No doubt genetic engineering and molecular breeding have helped in comprehending the intricate nature of stress response. Understanding of abiotic stress-involved cellular pathways provides vital information on such responses. On the other hand, genomic research for crop improvement has raised new assessments in breeding new varieties against abiotic stresses. Interpretation of responses of the crop plants under stress is of great significance by studying the main role of crops in food and biofuel production. This review presents genomic-based approaches revealing the complex networks controlling the mechanisms of abiotic stress tolerance, and the possible modes of assimilating information attained by genomic-based approaches due to the advancement in isolation and functional analysis of genes controlling the yield and abiotic stress tolerance are discussed. PMID:26440315

  9. Strategies To Boost Maternal Immunization To Achieve Further Gains In Improved Maternal And Newborn Health.

    PubMed

    Steedman, Mark R; Kampmann, Beate; Schillings, Egbert; Al Kuwari, Hanan; Darzi, Ara

    2016-02-01

    Despite the indisputable successes of the United Nations Millennium Development Goals, which include goals on improving maternal health and reducing child mortality, millions of mothers and newborns still die tragically and unnecessarily each year. Many of these deaths result from vaccine-preventable diseases, since obstacles such as cost and accessibility have hampered efforts to deliver efficacious vaccines to those most in need. Additionally, many vaccines given to mothers and children under age five are not suitable for newborns, since their maturing immune systems do not respond optimally during the first few months of life. Maternal immunization-the process by which a pregnant woman's immune system is fortified against a particular disease and the protection is then transferred to her unborn child-has emerged as a strategy to prevent many unnecessary maternal and newborn deaths. We review vaccines that are already used for maternal immunization, analyze vaccines under development that could be used for maternal immunization strategies in the future, and recommend that policy makers use maternal immunization for improved maternal and newborn health. PMID:26858385

  10. Can developing countries achieve adequate improvements in child health outcomes without engaging the private sector?

    PubMed Central

    Bustreo, Flavia; Harding, April; Axelsson, Henrik

    2003-01-01

    The private sector exerts a significant and critical influence on child health outcomes in developing countries, including the health of poor children. This article reviews the available evidence on private sector utilization and quality of care. It provides a framework for analysing the private sector's influence on child health outcomes. This influence goes beyond service provision by private providers and nongovernmental organizations (NGOs). Pharmacies, drug sellers, private suppliers, and food producers also have an impact on the health of children. Many governments are experimenting with strategies to engage the private sector to improve child health. The article analyses some of the most promising strategies, and suggests that a number of constraints make it hard for policy-makers to emulate these approaches. Few experiences are clearly described, monitored, and evaluated. The article suggests that improving the impact of child health programmes in developing countries requires a more systematic analysis of how to engage the private sector most effectively. The starting point should include the evaluation of the presence and potential of the private sector, including actors such as professional associations, producer organizations, community groups, and patients' organizations. PMID:14997241

  11. Anti-idiotypic antibodies as cancer vaccines: achievements and future improvements

    PubMed Central

    Ladjemi, Maha Z.

    2012-01-01

    Since the discovery of tumor-associated antigens (TAAs), researchers have tried to develop immune-based anti-cancer therapies. Thanks to their specificity, monoclonal antibodies (mAbs) offer the major advantage to induce fewer side effects than those caused by non-specific conventional treatments (e.g., chemotherapy, radiotherapy). Passive immunotherapy by means of mAbs or cytokines has proved efficacy in oncology and validated the use of immune-based agents as part of anti-cancer treatment options. The next step was to try to induce an active immune protection aiming to boost own’s host immune defense against TAAs. Cancer vaccines are thus developed to specifically induce active immune protection targeting only tumor cells while preserving normal tissues from a non-specific toxicity. But, as most of TAAs are self antigens, an immune tolerance against them exists representing a barrier to effective vaccination against these oncoproteins. One promising approach to break this immune tolerance consists in the use of anti-idiotypic (anti-Id) mAbs, so called Ab2, as antigen surrogates. This vaccination strategy allows also immunization against non-proteic antigens (such as carbohydrates). In some clinical studies, anti-Id cancer vaccines indeed induced efficient humoral and/or cellular immune responses associated with clinical benefit. This review article will focus on recent achievements of anti-Id mAbs use as cancer vaccines in solid tumors. PMID:23133825

  12. Exemplary Care and Learning Sites: A Model for Achieving Continual Improvement in Care and Learning in the Clinical Setting

    PubMed Central

    Ogrinc, Greg; Hoffman, Kimberly G.; Stevenson, Katherine M.; Shalaby, Marc; Beard, Albertine S.; Thörne, Karin E.; Coleman, Mary T.; Baum, Karyn D.

    2016-01-01

    Problem Current models of health care quality improvement do not explicitly describe the role of health professions education. The authors propose the Exemplary Care and Learning Site (ECLS) model as an approach to achieving continual improvement in care and learning in the clinical setting. Approach From 2008–2012, an iterative, interactive process was used to develop the ECLS model and its core elements—patients and families informing process changes; trainees engaging both in care and the improvement of care; leaders knowing, valuing, and practicing improvement; data transforming into useful information; and health professionals competently engaging both in care improvement and teaching about care improvement. In 2012–2013, a three-part feasibility test of the model, including a site self-assessment, an independent review of each site’s ratings, and implementation case stories, was conducted at six clinical teaching sites (in the United States and Sweden). Outcomes Site leaders reported the ECLS model provided a systematic approach toward improving patient (and population) outcomes, system performance, and professional development. Most sites found it challenging to incorporate the patients and families element. The trainee element was strong at four sites. The leadership and data elements were self-assessed as the most fully developed. The health professionals element exhibited the greatest variability across sites. Next Steps The next test of the model should be prospective, linked to clinical and educa tional outcomes, to evaluate whether it helps care delivery teams, educators, and patients and families take action to achieve better patient (and population) outcomes, system performance, and professional development. PMID:26760058

  13. An experimentally determined evolutionary model dramatically improves phylogenetic fit.

    PubMed

    Bloom, Jesse D

    2014-08-01

    All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models do not realistically represent the site-heterogeneous selection that governs actual sequence change. Attempts to remedy this problem have involved augmenting these models with a burgeoning number of free parameters. Here, I demonstrate an alternative: Experimental determination of a parameter-free evolutionary model via mutagenesis, functional selection, and deep sequencing. Using this strategy, I create an evolutionary model for influenza nucleoprotein that describes the gene phylogeny far better than existing models with dozens or even hundreds of free parameters. Emerging high-throughput experimental strategies such as the one employed here provide fundamentally new information that has the potential to transform the sensitivity of phylogenetic and genetic analyses. PMID:24859245

  14. The Results Fieldbook: Practical Strategies from Dramatically Improved Schools.

    ERIC Educational Resources Information Center

    Schmoker, Mike

    This book offers methods on how to cultivate and capture teacher expertise--one of the most grossly underused assets in education. These methods are simple and include goal-oriented, data-driven collaboration and ongoing assessment that can lead to an array of effective innovations and strategies to enhance school effectiveness. Five case-study…

  15. How PEPFAR's public-private partnerships achieved ambitious goals, from improving labs to strengthening supply chains.

    PubMed

    Sturchio, Jeffrey L; Cohen, Gary M

    2012-07-01

    The President's Emergency Plan for AIDS Relief (PEPFAR), established in 2003, is widely recognized as one of the most ambitious and successful bilateral programs ever implemented to address a single disease. Part of the program's success is attributable to the participation of the private sector, working in partnership with the US and local governments and implementing organizations to maximize the reach and effectiveness of every dollar spent. We examined key public-private partnerships that grew out of PEPFAR to identify features that have made them effective. For example, PEPFAR's Supply Chain Management System took advantage of private industry's best practices in logistics, and a partnership with the medical technology company BD (Becton, Dickinson and Company) improved laboratory systems throughout sub-Saharan Africa. We found that setting ambitious goals, enlisting both global and local partners, cultivating a culture of collaboration, careful planning, continuous monitoring and evaluation, and measuring outcomes systematically led to the most effective programs. The Office of the US Global AIDS Coordinator and PEPFAR should continue to strengthen their capacity for private-sector partnerships, learning from a decade of experience and identifying new ways to make smart investments that will make the most efficient use of taxpayer resources, expand proven interventions more rapidly, and help ensure the sustainability of key programs. PMID:22778334

  16. Mismatched partners that achieve postpairing behavioral similarity improve their reproductive success

    PubMed Central

    Laubu, Chloé; Dechaume-Moncharmont, François-Xavier; Motreuil, Sébastien; Schweitzer, Cécile

    2016-01-01

    Behavioral similarity between partners is likely to promote within-pair compatibility and to result in better reproductive success. Therefore, individuals are expected to choose a partner that is alike in behavioral type. However, mate searching is very costly and does not guarantee finding a matching partner. If mismatched individuals pair, they may benefit from increasing their similarity after pairing. We show in a monogamous fish species—the convict cichlid—that the behavioral similarity between mismatched partners can increase after pairing. This increase resulted from asymmetrical adjustment because only the reactive individual became more alike its proactive partner, whereas the latter did not change its behavior. The mismatched pairs that increased their similarity not only improved their reproductive success but also raised it up to the level of matched pairs. While most studies assume that assortative mating results from mate choice, our study suggests that postpairing adjustment could be an alternative explanation for the high behavioral similarity between partners observed in the field. It also explains why interindividual behavioral differences can be maintained within a given population. PMID:26973869

  17. Exercise Improves Executive Function and Achievement and Alters Brain Activation in Overweight Children: A Randomized Controlled Trial

    PubMed Central

    Davis, Catherine L.; Tomporowski, Phillip D.; McDowell, Jennifer E.; Austin, Benjamin P.; Miller, Patricia H.; Yanasak, Nathan E.; Allison, Jerry D.; Naglieri, Jack A.

    2010-01-01

    Objective This experiment tested the hypothesis that exercise would improve executive function. Design Sedentary, overweight 7- to 11-year-old children (N = 171, 56% female, 61% Black, M ± SD age 9.3 ± 1.0 yrs, body mass index (BMI) 26 ± 4.6 kg/m2, BMI z-score 2.1 ± 0.4) were randomized to 13 ± 1.6 weeks of an exercise program (20 or 40 minutes/day), or a control condition. Main outcome measures Blinded, standardized psychological evaluations (Cognitive Assessment System and Woodcock-Johnson Tests of Achievement III) assessed cognition and academic achievement. Functional magnetic resonance imaging measured brain activity during executive function tasks. Results Intent to treat analysis revealed dose response benefits of exercise on executive function and mathematics achievement. Preliminary evidence of increased bilateral prefrontal cortex activity and reduced bilateral posterior parietal cortex activity due to exercise was also observed. Conclusion Consistent with results obtained in older adults, a specific improvement on executive function and brain activation changes due to exercise were observed. The cognitive and achievement results add evidence of dose response, and extend experimental evidence into childhood. This study provides information on an educational outcome. Besides its importance for maintaining weight and reducing health risks during a childhood obesity epidemic, physical activity may prove to be a simple, important method of enhancing aspects of children’s mental functioning that are central to cognitive development. This information may persuade educators to implement vigorous physical activity. PMID:21299297

  18. Maverick Comet Splits during Dramatic Outburst

    NASA Astrophysics Data System (ADS)

    1996-01-01

    New ESO Observations of P/Schwassmann-Wachmann 3 A few months ago, Periodic Comet Schwassmann-Wachmann 3 underwent a dramatic and completely unexpected, thousand-fold brightening. At that time, the cause for this interesting event was unknown. However, observations with the two largest ESO telescopes have now shown that the ``dirty snowball'' nucleus of this comet has recently split into at least four individual pieces [1]. There is little doubt that the outburst and the splitting event(s) are closely related and that the greatly increased dust and gas production is due to ``fresh'' material of the icy cometary nucleus becoming exposed to the surrounding space for the first time. A Comet with a Troubled History Comet Schwassmann-Wachmann 3 was discovered on May 2, 1930, on a photographic plate obtained at the Hamburg Observatory (Germany) by two astronomers at this institution, Arnold Schwassmann and Arthur Arno Wachmann. The subsequent observations showed that the comet moved in an elliptical orbit with a revolution period of somewhat more than 5 years. Great efforts were expended to observe the comet during the next returns, but it was not recovered until nearly 50 years and eight revolutions later, when its faint image was found of a plate obtained in August 1979 with a telescope at the Perth Observatory in Western Australia. It was missed in 1984, but was sighted again in 1989 and most recently in 1994. Thus this comet has only been observed during four out of thirteen approaches since 1930. While this may be partly due to a less advantageous location in the sky at some returns, it is also a strong indication that the comet behaves unpredictably and must have a quite variable brightness. For the sake of convenience this comet is often referred to as ``SW-3'' by professional astronomers. Recent orbital calculations have shown that it was inserted into the present, short-period orbit by the strong gravitational pull of Jupiter during several, relatively close

  19. A Sacrificial Lam: A Divided School Board, a Beleaguered Superintendent, and an Urgent Need to Improve Student Achievement

    ERIC Educational Resources Information Center

    Fossey, Richard

    2011-01-01

    This case describes the confrontational relationship between four trustees on the San Antonio School Board and the San Antonio School District's superintendent Diana Lam, a nationally recognized school reformer, who came to San Antonio in 1994. The case includes a dramatic board meeting where a closely divided board meets to buy out Lam's…

  20. Organizing Schools to Improve Student Achievement: Start Times, Grade Configurations, and Teacher Assignments. Discussion Paper 2011-08

    ERIC Educational Resources Information Center

    Jacob, Brian A.; Rockoff, Jonah E.

    2011-01-01

    Education reform proposals are often based on high-profile or dramatic policy changes, many of which are expensive, politically controversial, or both. In this paper, we argue that the debates over these "flashy" policies have obscured a potentially important direction for raising student performance--namely, reforms to the management or…

  1. Out-of-School-Time Academic Programs to Improve School Achievement: A Community Guide Health Equity Systematic Review

    PubMed Central

    Knopf, John A.; Hahn, Robert A.; Proia, Krista K.; Truman, Benedict I.; Johnson, Robert L.; Muntaner, Carles; Fielding, Jonathan E.; Jones, Camara Phyllis; Fullilove, Mindy T.; Hunt, Pete C.; Qu, Shuli; Chattopadhyay, Sajal K.; Milstein, Bobby

    2015-01-01

    Context Low-income and minority status in the United States are associated with poor educational outcomes, which, in turn, reduce the long-term health benefits of education. Objective This systematic review assessed the extent to which out-of-school-time academic (OSTA) programs for at-risk students, most of whom are from low-income and racial/ethnic minority families, can improve academic achievement. Because most OSTA programs serve low-income and ethnic/racial minority students, programs may improve health equity. Design Methods of the Guide to Community Preventive Services were used. An existing systematic review assessing the effects of OSTA programs on academic outcomes (Lauer et al 2006; search period 1985–2003) was supplemented with a Community Guide update (search period 2003–2011). Main Outcome Measure Standardized mean difference. Results Thirty-two studies from the existing review and 25 studies from the update were combined and stratified by program focus (ie, reading-focused, math-focused, general academic programs, and programs with minimal academic focus). Focused programs were more effective than general or minimal academic programs. Reading-focused programs were effective only for students in grades K-3. There was insufficient evidence to determine effectiveness on behavioral outcomes and longer-term academic outcomes. Conclusions OSTA programs, particularly focused programs, are effective in increasing academic achievement for at-risk students. Ongoing school and social environments that support learning and development may be essential to ensure the longer-term benefits of OSTA programs. PMID:26062096

  2. Dramatic innovations in modern surgical subspecialties

    PubMed Central

    Ball, Chad G.; Sutherland, Francis; Kirkpatrick, Andrew W.; Dixon, Elijah; MacLean, Anthony R.; Mack, Lloyd A.; Feliciano, David V.; Rajani, Ravi R.; Karmy-Jones, Riyad; Buie, W. Donald; Temple, Walley J.; Rozycki, Grace S.; Simeone, Alan

    2010-01-01

    Innovation is defined as the introduction of something new, whether an idea, method or device. In this article, we describe the most important and innovative concepts and techniques that have advanced patient care within modern surgical subspecialties. We performed a systematic literature review and consulted academic subspecialty experts to evaluate recent changes in practice. The identified innovations included reduced blood loss and improved training in hepatobiliary surgery, total mesorectal excision and neoadjuvant therapies in colorectal surgery, prosthetic mesh in outpatient surgery, sentinel lymph node theory in surgical oncology, endovascular and wire-based skills in vascular and cardiovascular surgery, and the acceptance of abnormal anatomy through damage-control procedures in trauma and critical care. The common denominator among all subspecialties is an improvement in patient care manifested as a decrease in morbidity and mortality. Surgeons must continue to pursue innovative thinking, technological advances, improved training and systematic research. PMID:20858379

  3. Cardiorespiratory Improvements Achieved by American College of Sports Medicine’s Exercise Prescription Implemented on a Mobile App

    PubMed Central

    Rospo, Gianluca; Valsecchi, Viola; Bonomi, Alberto G; Thomassen, Inge WJ; van Dantzig, Saskia; La Torre, Antonio

    2016-01-01

    Background Strong evidence shows that an increase in cardiorespiratory fitness (CRF) and physical activity (PA) reduces cardiovascular disease risk. Objective To test whether a scientifically endorsed program to increase CRF and PA, implemented on an easy-to-use, always-accessible mobile app would be effective in improving CRF. Methods Of 63 healthy volunteers participating, 18 tested the user interface of the Cardio-Fitness App (CF-App); and 45 underwent a 2-week intervention period, of whom 33 eventually concluded it. These were assigned into three groups. The Step-based App (Step-App) group (n=8), followed 10,000 steps/day prescription, the CF-App group (n=13), and the Supervised Cardio-Fitness (Super-CF) group (n=12), both followed a heart rate (HR)-based program according to American College of Sports Medicine (ACSM) guidelines, but either implemented on the app, or at the gym, respectively. Participants were tested for CRF, PA, resting systolic and diastolic blood pressures (SBP, DBP), resting, exercise, and recovery HR. Results CRF increased in all groups (+4.9%; P<.001). SBP decreased in all groups (-2.6 mm Hg; P=.03). DBP decrease was higher in the Super-CF group (-3.5 mm Hg) than in the Step-App group (-2.1 mm Hg; P<.001). Posttest exercise HR decreased in all groups (-3.4 bpm; P=.02). Posttest recovery HR was lower in the Super-CF group (-10.1 bpm) than in the other two groups (CF-App: -4.9 bpm, Step-App: -3.3 bpm; P<.001). The CF-App group, however, achieved these improvements with more training heart beats (P<.01). Conclusions A 10,000 steps/day target-based app improved CRF similar to an ACSM guideline-based program whether it was implemented on a mobile app or in supervised gym sessions. PMID:27339153

  4. "Play for Real": Understanding Middle School Children's Dramatic Play.

    ERIC Educational Resources Information Center

    Sierra, Zayda

    2000-01-01

    Summarizes a dissertation that examines the theory and practice of dramatic play among middle school children. Finds that they are still adept and interested in dramatic play. Discusses four components describing the nature and product of the dramatic process (social interactions, metacognitive strategies, ideational processes, and content of…

  5. How To Use Creative Dramatics in the Classroom.

    ERIC Educational Resources Information Center

    Johnson, Andrew P.

    1998-01-01

    Provides specific steps and techniques for teaching and using creative dramatics in elementary school classrooms. Notes that creative dramatics address children's powerful emotions and imaginations, which children rely on to explore and understand the world. Discusses four necessary components of creative dramatics--structure, open-endedness, a…

  6. Creative Dramatics: The Perfect Tool for Gifted Students.

    ERIC Educational Resources Information Center

    Johnson, Andrew P.

    2000-01-01

    Discussion of the use of creative dramatics with gifted students considers the value of creative dramatics; components of creative dramatics (structure, open-endedness, a safe environment, and feedback); the actor's elements (voice, body, character or imagination, and group work). Specific exercises to develop the actor's elements are described.…

  7. Dramatic Outburst Reveals Nearest Black Hole

    NASA Astrophysics Data System (ADS)

    2000-01-01

    Scientists have discovered the closest black hole yet, a mere 1,600 light years from Earth. Its discovery was heralded by four of the most dramatic rapid X-ray intensity changes ever seen from one star. Astronomers from the Massachusetts Institute of Technology (MIT) and the National Science Foundation's National Radio Astronomy Observatory (NRAO) announced their findings at the American Astronomical Society's meeting in Atlanta. The black hole in the constellation Sagittarius, along with a normal star dubbed V4641 Sgr, form a violent system that briefly flooded part of our Milky Way Galaxy with X-rays and ejected subatomic particles moving at nearly the speed of light one day last September. At the peak of its X-ray output, V4641 Sgr was the brightest X-ray emitter in the sky. Astronomers call this type of system an X-ray nova because it suddenly becomes a bright source of X-rays, but this object shows characteristics never seen in an X-ray nova. "V4641 Sgr turns on and off so fast that it seems to represent a new subclass of X-ray novae," said Donald A. Smith, postdoctoral associate in MIT's Center for Space Research. Smith worked on data from this object with MIT principal research scientist Ronald Remillard and NRAO astronomer Robert Hjellming. "In X-rays, the intensity rose by a factor of more than 1,000 in seven hours, then dropped by a factor of 100 in two hours," Remillard said. The radio emission was seen as an image of an expanding "jet" of particles shooting out from the binary system. After reaching a maximum, the radio intensity dropped by a factor of nearly 40 within two days. "Radio telescopes give us a quick glimpse of something moving at a fantastically high velocity," Hjellming said. Black holes harbor enormous gravitational force that can literally rip the gas away from a nearby star. This transfer of gas is visible in many forms of radiation. Both orbiting X-ray telescopes and ground-based radio and optical telescopes saw the outburst of V4641

  8. Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes

    PubMed Central

    Homma, R.; Cohen, L. B.; Kosmidis, E. K.; Youngentob, S. L.

    2009-01-01

    We compared the concentration dependence of the ability of rats to identify odorants with the calcium signals in the nerve terminals of the olfactory receptor neurons. Although identification performance decreased with concentrations both above and below the training stimuli it remained well above random at all concentrations tested (between 0.0006% and 35% of saturated vapor). In contrast, the calcium signals in the same awake animals were much smaller than their maximum values at odorant concentrations less than 1% of saturated vapor. In addition, maps of activated glomeruli changed dramatically as odorant concentration was reduced. Thus perceptual stability exists in the face of dramatic changes in both the amplitude and the maps of the input to the olfactory bulb. The data for the concentration dependence of the response of the most sensitive glomeruli for each of five odorants was fitted with a Michaelis-Menten (Hill) equation. The fitted curves were extrapolated to odorant concentrations several orders of magnitude lower the smallest observed signals and suggest that the calcium response at low odorant concentrations is more than 1000 times smaller than the response at saturating odorant concentrations. We speculate that only a few spikes in olfactory sensory neurons may be sufficient for correct odorant identification. PMID:19291227

  9. Improved yields of full-length functional human FGF1 can be achieved using the methylotrophic yeast Pichia pastoris.

    PubMed

    Fantoni, Adele; Bill, Roslyn M; Gustafsson, Lena; Hedfalk, Kristina

    2007-03-01

    We have produced human fibroblast growth factor 1 (hFGF1) in the methylotrophic yeast Pichia pastoris in order to obtain the large amounts of active protein required for subsequent functional and structural characterization. Four constructs were made to examine both intracellular and secreted expression, with variations in the location of the His6 tag at either end of the peptide. hFGF1 could be produced from all four constructs in shake flasks, but production was optimized by growing only the highest-yielding of these strains, which produced hFGF1 intracellularly, under tightly controlled conditions in a 3 L fermentor. One hundred and eight milligrams of pure protein was achieved per liter culture (corresponding to 0.68 mg of protein per gram of wet cells), the function of which was verified using NIH 3T3 cell cultures. This is a 30-fold improvement over previously reported yields of full-length hFGF1. PMID:17134911

  10. Dramatic Demand Reduction In The Desert Southwest

    SciTech Connect

    Boehm, Robert; Hsieh, Sean; Lee, Joon; Baghzouz, Yahia; Cross, Andrew; Chatterjee, Sarah

    2015-07-06

    This report summarizes a project that was funded to the University of Nevada Las Vegas (UNLV), with subcontractors Pulte Homes and NV Energy. The project was motivated by the fact that locations in the Desert Southwest portion of the US demonstrate very high peak electrical demands, typically in the late afternoons in the summer. These high demands often require high priced power to supply the needs, and the large loads can cause grid supply problems. An approach was proposed through this contact that would reduce the peak electrical demands to an anticipated 65% of what code-built houses of the similar size would have. It was proposed to achieve energy reduction through four approaches applied to a development of 185 homes in northwest part of Las Vegas named Villa Trieste. First, the homes would all be highly energy efficient. Secondly, each house would have a PV array installed on it. Third, an advanced demand response technique would be developed to allow the resident to have some control over the energy used. Finally, some type of battery storage would be used in the project. Pulte Homes designed the houses. The company considered initial cost vs. long-term savings and chose options that had relatively short paybacks. HERS (Home Energy Rating Service) ratings for the homes are approximately 43 on this scale. On this scale, code-built homes rate at 100, zero energy homes rate a 0, and Energy Star homes are 85. In addition a 1.764 Wp (peak Watt) rated PV array was used on each house. This was made up of solar shakes that were in visual harmony with the roofing material used. A demand response tool was developed to control the amount of electricity used during times of peak demand. While demand response techniques have been used in the utility industry for some time, this particular approach is designed to allow the customer to decide the degree of participation in the response activity. The temperature change in the residence can be decided by the residents by

  11. Using Dramatic Events and Visualization Technology to Teach About Watersheds

    NASA Astrophysics Data System (ADS)

    Huth, A. K.; Hall, M. K.

    2008-12-01

    We developed a GIS-based, two-unit module about dynamic watersheds that uses spatial visualization tools, inquiry-based questioning, and eyewitness accounts of historical, dramatic events to teach students about the natural phenomenon of watershed evolution. The module puts into context the relationship between watersheds and human behavior. The centerpiece of Unit 1 is the Big Thompson watershed in Colorado and the flash flood that killed 145 people in 1976. Unit 2 is a case history of the Sabino Canyon watershed in Arizona, which was ravaged by wildfires in 2002 and 2003, as well as destructive debris flows in 2006. Students examine the causes and magnitude of each of these events, and how they changed landscapes and people. Both units use MyWorld GIS and Google Earth visualization software tools. A teacher workshop in summer 2008 revealed an increased understanding of watersheds and an improved comfort level using spatial visualization software after working with the module. Prior to the workshop, a survey demonstrated that fewer than 50 percent of the workshop participants knew the name of the watershed in which they lived. After the workshop, all teachers were able to conceptually define a watershed, identify the watershed in which they live, and describe hazards that would put a watershed and its communities at risk for dramatic changes. They also showed an increased awareness of seasonal variations in streamflow and made connections between these variations and the sources that generate streamflow in different watersheds. We expect similar results among high-school students who will field test these materials during the Fall 2008 semester.

  12. Playing around with Improvisation: An Analysis of the Text Creation Processes Used within Preadolescent Dramatic Play

    ERIC Educational Resources Information Center

    Dunn, Julie

    2008-01-01

    When children come together to play dramatically they are involved in the creation of an improvised text. This text emerges spontaneously via the moment-by-moment contributions of individual players who must operate in a highly collaborative way in order to achieve cohesion. This paper reports on a research project involving several groups of 11-…

  13. [A mixed germ cell tumor that underwent dramatic size changes].

    PubMed

    Kuwayama, Kazuyuki; Takai, Hiroki; Nishiyama, Akira; Hirai, Satoshi; Yokosuka, Kimihiko; Toi, Hiroyuki; Hirano, Kazuhiro; Matsubara, Shunji; Uno, Masaaki; Nishimura, Hirotake

    2014-09-01

    This report describes a mixed germ cell tumor that underwent dramatic size changes. A 12-year-old boy presented to our hospital with a headache that had persisted for two months. Initial magnetic resonance imaging (MRI) revealed a pineal tumor and hydrocephalus. The patient required external ventricular drainage and underwent two endoscopic biopsies. His evaluation involved a total of nine computed tomography (CT) scans prior to the second biopsy;the tumor size had decreased before the second endoscopic biopsy. The tumor consisted of both a germinoma and a teratoma component. The patient was treated with three courses of carboplatin-etoposide (CBDCA-VP) chemotherapy and whole-ventricle radiotherapy (32.1 Gy). However, during the adjuvant therapy, the tumor size increased, necessitating total tumor resection. We speculate that the tumor's initial size reduction was caused by leakage of the cyst component and exposure to the brain CT irradiation. The tumor's subsequent increase in size was due to the recollection of the cystic components and intracranial growing teratoma syndrome (iGTS). Therefore, frequent brain CTs and angiography should be avoided before definitive pathological diagnosis is achieved. Further, the tumor size should be considered, with surgical resection being performed at the optimal time. PMID:25179200

  14. Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms

    PubMed Central

    Binnebose, Andrea M.; Haughney, Shannon L.; Martin, Richard; Imerman, Paula M.; Narasimhan, Balaji; Bellaire, Bryan H.

    2015-01-01

    Filarial diseases represent a significant social and economic burden to over 120 million people worldwide and are caused by endoparasites that require the presence of symbiotic bacteria of the genus Wolbachia for fertility and viability of the host parasite. Targeting Wolbachia for elimination is a therapeutic approach that shows promise in the treatment of onchocerciasis and lymphatic filariasis. Here we demonstrate the use of a biodegradable polyanhydride nanoparticle-based platform for the co-delivery of the antibiotic doxycycline with the antiparasitic drug, ivermectin, to reduce microfilarial burden and rapidly kill adult worms. When doxycycline and ivermectin were co-delivered within polyanhydride nanoparticles, effective killing of adult female Brugia malayi filarial worms was achieved with approximately 4,000-fold reduction in the amount of drug used. Additionally the time to death of the macrofilaria was also significantly reduced (five-fold) when the anti-filarial drug cocktail was delivered within polyanhydride nanoparticles. We hypothesize that the mechanism behind this dramatically enhanced killing of the macrofilaria is the ability of the polyanhydride nanoparticles to behave as a Trojan horse and penetrate the cuticle, bypassing excretory pumps of B. malayi, and effectively deliver drug directly to both the worm and Wolbachia at high enough microenvironmental concentrations to cause death. These provocative findings may have significant consequences for the reduction in the amount of drug and the length of treatment required for filarial infections in terms of patient compliance and reduced cost of treatment. PMID:26496201

  15. Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

    PubMed

    Binnebose, Andrea M; Haughney, Shannon L; Martin, Richard; Imerman, Paula M; Narasimhan, Balaji; Bellaire, Bryan H

    2015-01-01

    Filarial diseases represent a significant social and economic burden to over 120 million people worldwide and are caused by endoparasites that require the presence of symbiotic bacteria of the genus Wolbachia for fertility and viability of the host parasite. Targeting Wolbachia for elimination is a therapeutic approach that shows promise in the treatment of onchocerciasis and lymphatic filariasis. Here we demonstrate the use of a biodegradable polyanhydride nanoparticle-based platform for the co-delivery of the antibiotic doxycycline with the antiparasitic drug, ivermectin, to reduce microfilarial burden and rapidly kill adult worms. When doxycycline and ivermectin were co-delivered within polyanhydride nanoparticles, effective killing of adult female Brugia malayi filarial worms was achieved with approximately 4,000-fold reduction in the amount of drug used. Additionally the time to death of the macrofilaria was also significantly reduced (five-fold) when the anti-filarial drug cocktail was delivered within polyanhydride nanoparticles. We hypothesize that the mechanism behind this dramatically enhanced killing of the macrofilaria is the ability of the polyanhydride nanoparticles to behave as a Trojan horse and penetrate the cuticle, bypassing excretory pumps of B. malayi, and effectively deliver drug directly to both the worm and Wolbachia at high enough microenvironmental concentrations to cause death. These provocative findings may have significant consequences for the reduction in the amount of drug and the length of treatment required for filarial infections in terms of patient compliance and reduced cost of treatment. PMID:26496201

  16. Making History Come Alive: Dramatization in the Classroom.

    ERIC Educational Resources Information Center

    Drake, Frederick D.; Corbin, Denee

    1993-01-01

    Asserts that people of all ages love a story that involves heroes and villains and that a teacher can bridge the gap between political and social history through dramatization. Describes procedures for identifying appropriate topics for dramatization and encouraging student involvement. (CFR)

  17. Cognitive Psychology and Audience-Oriented Dramatic Theory.

    ERIC Educational Resources Information Center

    Bratt, David

    Cognitive psychology's most useful contribution to dramatic theory is the concept of schemata, or the mental structures that make up part of the perceptual cycle. In regard to an audience-oriented dramatic theory, this suggests that analysis of a script ought to identify the sorts of schemata that are to be aroused in the audience's minds and the…

  18. Dramatic Activities in Language Arts Classrooms: Resource Summary. ERIC Digest.

    ERIC Educational Resources Information Center

    Tatar, Sibel

    This digest reviews some of the related literature about the benefits of classroom drama activities and introduces a variety of resources to help educators incorporate dramatic activities in their language arts classrooms. The digest notes that although several terms have been used to refer to "classroom drama" such as creative dramatics,…

  19. Dramatic Arts in the Secondary School, MSA Curriculum Guide 6.

    ERIC Educational Resources Information Center

    Herman, Deldee M., Ed.; Ratliffe, Sharon A., Ed.

    This volume of the Michigan Speech Association curriculum guide is a revision of the 1968 edition (ED 026 389). The first eight units comprise a first semester course that emphasizes theatre history, dramatic structure, and dramatic criticism and theory. There are also units on presenting a one-act play, music in the theatre, and children's…

  20. Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption.

    PubMed

    Zhang, Zhanping; Ma, Hongwei; Hausner, Douglas B; Chilkoti, Ashutosh; Beebe, Thomas P

    2005-01-01

    New applications in regenerative biotechnology require the ability to understand and control protein-surface interactions on micrometer and submicrometer length scales. Evidence presented here shows that micropatterned amphiphilic comb polymer films exhibit a pretreatment-dependent behavior with respect to protein adsorption for the proteins fibronectin, laminin, and for serum. A micropatterned surface, consisting of protein-reactive regions, separated by comb polymer, was created and tested for protein adsorption using the surface-sensitive imaging tool TOF-SIMS. Immersion of micropatterned surfaces in solutions of fibronectin or laminin resulted in uniform protein coverage on both the comb polymer and protein-reactive regions. However, preimmersion of similarly patterned surfaces in water for 2 h prior to protein incubation was found to dramatically improve the protein-resistant properties of the comb polymer regions. These results are consistent with poly(ethylene glycol) (PEG) side chain reorientation and/or hydration and poly(methyl methacrylate) (PMMA) backbone segregation away from the interface region. PMID:16283770

  1. A Mixed-Methods Study of the Transformation Model for Rapid Improvement of Low Achieving Rural Schools

    ERIC Educational Resources Information Center

    Atkinson Duina, Angela

    2013-01-01

    New regulations attached to ARRA funding of federal School Improvement Fund grants aimed at producing rapid turnaround of low performing schools were highly criticized as unsuitable for rural schools. This mixed-methods study looked at the implementation of the School Improvement Fund Transformation Model in two rural Maine high schools during the…

  2. In Their Own Words: Erasing Deficits and Exploring What Works to Improve K-12 and Postsecondary Black Male School Achievement

    ERIC Educational Resources Information Center

    Warren, Chezare A.; Douglas, Ty-Ron M. O.; Howard, Tyrone C.

    2016-01-01

    This article outlines the imperative for strengths-based research to counter deficit perceptions and perspectives of Black males in contemporary discussions of their school achievement in the United States. The importance of young men of color in shaping research agendas, practice, and public policy is argued followed by a brief overview of the…

  3. Improving Secondary School Students' Achievement and Retention in Biology through Video-Based Multimedia Instruction

    ERIC Educational Resources Information Center

    Gambari, Amosa Isiaka; Yaki, Akawo Angwal; Gana, Eli S.; Ughovwa, Queen Eguono

    2014-01-01

    The study examined the effects of video-based multimedia instruction on secondary school students' achievement and retention in biology. In Nigeria, 120 students (60 boys and 60 girls) were randomly selected from four secondary schools assigned either into one of three experimental groups: Animation + Narration; Animation + On-screen Text;…

  4. The Potential for School-Based Interventions That Target Executive Function to Improve Academic Achievement: A Review

    ERIC Educational Resources Information Center

    Jacob, Robin; Parkinson, Julia

    2015-01-01

    This article systematically reviews what is known empirically about the association between executive function and student achievement in both reading and math and critically assesses the evidence for a causal association between the two. Using meta-analytic techniques, the review finds that there is a moderate unconditional association between…

  5. Surmounting the Challenges of Improving Academic Performance: Closing the Achievement Gap through Social-Emotional and Character Development

    ERIC Educational Resources Information Center

    Elias, Maurice J.; White, Gwyne; Stepney, Cesalie

    2014-01-01

    While educators and policy makers have an intuitive understanding of the influence of socioeconomic factors and race on student achievement, these factors make the current emphasis on standardized test scores as a primary criterion for evaluating schools and teachers indefensible and ineffective. The research presented illustrates the limits of…

  6. Do Career and Technical Education Programs of Study Improve Student Achievement? Preliminary Analyses from a Rigorous Longitudinal Study

    ERIC Educational Resources Information Center

    Castellano, Marisa; Sundell, Kirsten; Overman, Laura T.; Aliaga, Oscar A.

    2012-01-01

    This longitudinal study examines the impact of programs of study on high school academic and technical achievement. Two districts are participating in experimental and quasi-experimental strands of the study. This article describes the sample selection, baseline characteristics, study design, career and technical education and academic achievement…

  7. Massachusetts Charter Public Schools: Best Practices Using Data to Improve Student Achievement in Springfield. White Paper No. 142

    ERIC Educational Resources Information Center

    Candal, Cara Stillings

    2016-01-01

    Recent studies continue to shine light on high-performing charter schools. While Boston-area charter schools--a concentrated group of high-performers--garner more attention than others, many excellent schools outside of Boston have been quietly chipping away at the achievement gap between advantaged and disadvantaged students. One of these schools…

  8. The Path to Math: Leadership Matters Effective Practices of Principals That Improve Student Achievement in Secondary Mathematics

    ERIC Educational Resources Information Center

    Pyo, Michelle Hyo Jung

    2013-01-01

    The quality of school leadership is linked to student academic achievement (Leithwood et al., 2004; Thompson & Barnes, 2007; Glatthorn & Jailall, 1997; Lezotte, 1991; Edmonds, 1979; Hallinger & Heck, 1996; Crum & Sherman, 2008). The purpose of this study was to examine the instructional leadership (IL) of high school principals and…

  9. Neurofeedback as an Intervention to Improve Reading Achievement in Students with Attention- Deficit/Hyperactivity Disorder, Inattentive Subtype

    ERIC Educational Resources Information Center

    La Marca, Jeffry P.; O'Connor, Rollanda E.

    2016-01-01

    Research consistently demonstrates that attention deficits have a deleterious effect on academic achievement. Impairments in attention, and not hyperactivity/impulsivity, are associated with learning difficulties and academic problems in students with attention-deficit/hyperactivity disorder (ADHD). To date, most studies have focused on symptoms…

  10. "Does Charter School Attendance Improve Test Scores?" Comments and Reactions on the Arizona Achievement Study. Upjohn Institute Staff Working Paper.

    ERIC Educational Resources Information Center

    Nelson, Christopher; Hollenbeck, Kevin

    In a recent report, Lewis Solmon, Kern Paark, and David Garcia (2001) seek to identify the impact of attending charter schools on student achievement using data from Arizona. Based on a sophisticated statistical analysis, these authors report that charter school attendance increases test score gains of students. This note raises some questions…

  11. Schooling and Cognitive Achievements of Children in Morocco: Can the Government Improve Outcomes? World Bank Discussion Papers, No. 264.

    ERIC Educational Resources Information Center

    Khandker, Shahidur R.; And Others

    This paper uses data from the Morocco Living Standard Survey in an econometric investigation of the relative effectiveness of supply- and demand-side factors in determining educational outcomes. A wide range of factors are examined that may be responsible for differences in grade completion levels and achievement among sexes, regions, and urban…

  12. Socio-Dramatic Affective-Relational Intervention for Adolescents with Asperger Syndrome & High Functioning Autism: Pilot Study

    ERIC Educational Resources Information Center

    Lerner, Matthew D.; Mikami, Amori Yee; Levine, Karen

    2011-01-01

    This study examined the effectiveness of a novel intervention called "socio-dramatic affective-relational intervention" (SDARI), intended to improve social skills among adolescents with Asperger syndrome and high functioning autism diagnoses. SDARI adapts dramatic training activities to focus on in vivo practice of areas of social skill deficit…

  13. Learning Achievement Improvement Efforts Course Learn and Learning Using the Jigsaw Method and Card Media in STKIP PGRI Ngawi 2014/2015 Academic Year

    ERIC Educational Resources Information Center

    Haryono

    2015-01-01

    Subject Teaching and Learning is a basic educational courses that must be taken by all student teachers. Class Action Research aims to improve student achievement Teaching and Learning course by applying Jigsaw and media cards. Research procedures using Classroom Action Research (CAR) with multiple cycles. Each cycle includes four phases:…

  14. Indirect Effects of the Family Check-up on School-Age Academic Achievement through Improvements in Parenting in Early Childhood

    ERIC Educational Resources Information Center

    Brennan, Lauretta M.; Shelleby, Elizabeth C.; Shaw, Daniel S.; Gardner, Frances; Dishion, Thomas J.; Wilson, Melvin

    2013-01-01

    This project examined the hypothesis that the impact of the Family Check-Up on parent use of positive behavior support would indirectly improve academic achievement scores at school age. The study included a sample of 731 high-risk families recruited from Women, Infant, and Children Supplemental Nutrition Program settings in 3 geographically…

  15. Improving the Teaching and Learning of Science in a Suburban Junior High School on Long Island: Achieving Parity through Cogenerative Dialogues

    ERIC Educational Resources Information Center

    Baker, Eileen Perman

    2010-01-01

    The research in this dissertation focuses on ways to improve the teaching and learning of science in a suburban junior high school on Long Island, New York. The study is my attempt to find ways to achieve parity in my classroom in terms of success in science. I was specifically looking for ways to encourage Black female students in my classroom…

  16. Collaborating to Create Change: How El Paso Community College Improved the Readiness of Its Incoming Students through Achieving the Dream. Culture of Evidence Series, Report No. 4

    ERIC Educational Resources Information Center

    Kerrigan, Monica Reid; Slater, Doug

    2010-01-01

    Launched in 2003, "Achieving the Dream: Community Colleges Count" is a multiyear national initiative designed to improve educational outcomes for community college students, particularly students of color and low-income students. Supported by Lumina Foundation for Education and other funders, the initiative has grown to include 98 community…

  17. Higher Achievement and Improvement Through Instruction with Computers and Scholarly Transition and Resource Systems Program (Project HAITI STARS), 1989-90. Final Evaluation Report.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    A final evaluation was conducted in the 1989-90 school year of New York City (New York) Board of Education's project, Higher Achievement and Improvement Through Instruction with Computers and Scholarly Transition and Resource Systems (HAITI STARS). The project served 524 limited-English-proficient Spanish-speaking students at Far Rockaway High…

  18. Higher Achievement and Improvement Through Instruction with Computers and Scholarly Transition And Resource Systems Program (Project HAITI STARS). Final Evaluation Report, 1992-93. OER Report.

    ERIC Educational Resources Information Center

    Augustin, Marc A.

    The Higher Achievement and Improvement Through Instruction with Computers and Scholarly Transition And Resource Systems program (Project HAITI STARS), a federally-funded bilingual education program, served 425 students of limited English proficiency at three high schools in New York City during its fifth contract year. Students received…

  19. How to Implement the Ways of Knowing through the Realms of Meaning as an Ethical Decision-Making Process to Improve Academic Achievement--Ten Recommendations

    ERIC Educational Resources Information Center

    Skinner, Desiree A.; Kritsonis, William Allan

    2006-01-01

    "Values, purposes, and understandings are fragile achievements and give way all too readily to attitudes of futility, frustration, and doubt" (Kritsonis, 2007, pg. 7). Ethical decision-making is one way for school leaders to contribute to improving education. Effecting change is the duty of school principals; this may often come in making…

  20. The Efforts to Improve Mathematics Learning Achievement Results of High School Students as Required by Competency-Based Curriculum and Lesson Level-Based Curriculum

    ERIC Educational Resources Information Center

    Sidabutar, Ropinus

    2016-01-01

    The research was aimed to investigate the effect of various, innovated teaching models to improved the student's achievement in various topic in Mathematics. The study was conduct experiment by using innovated teaching with contextual, media and web which are the compared. with conventional teaching method. The result showed the innovation in the…

  1. Improving Reading Achievement of Chapter 1 Pull-Out Students through Self-Esteem Building Classes Involving Buddy Group and Teacher Participation.

    ERIC Educational Resources Information Center

    Hershfield, Marlene

    A practicum attempted to improve the low reading achievement of Chapter 1 students in a low socioeconomic fifth-grade class by implementing a self-esteem building program. Activities were designed in a workbook format to complement class instruction in self-esteem building exercises. An emphasis on critical thinking skills was incorporated into…

  2. Video Taping and Abnormal Psychology: Dramatized Clinical Interviews.

    ERIC Educational Resources Information Center

    Lyons, Michael J.; And Others

    1984-01-01

    Students in an abnormal psychology course worked in teams to produce dramatizations of diagnostic interviews and then presented them in class. Positive and negative aspects of the activity are discussed. (RM)

  3. Writing a Book about Dorothy Heathcote's Dramatic Approach to Education.

    ERIC Educational Resources Information Center

    Bolton, Gavin

    1993-01-01

    Discusses the development of a book about Dorothy Heathcote's dramatic approach to education. Describes a lesson on "bullying" that illustrates an attempt to implement Heathcote's "Mantle of the Expert" method. (RS)

  4. Dramatically Enhanced Flux Pinning Properties of Cation Composition Controlled Bi(Pb)2212 Single Crystals

    NASA Astrophysics Data System (ADS)

    Uchida, Satoshi; Shimoyama, Jun-Ichi; Makise, Takanori; Horii, Shigeru; Kishio, Kohji

    2006-06-01

    Single crystals of Bi2212 and Bi(Pb)2212 having various cation compositions were grown by the floating zone method and evaluated their Jc characteristics after control of oxygen content by post-annealing. Jc characteristics of Bi2212 and Bi(Pb)2212 were found to be improved by control of cation compositions towards stoichiometric, Bi:Sr:Ca:Cu = 2:2:1:2. This means that nonstoichiometric cation composition in these systems suppresses inherent superconductivity possibly due to considerably disordered crystal lattice, resulting in poor Jc characteristics. Dramatically enhanced Jc were achieved for cation stoichiometric and small amount of Y or Lu-doped Bi(Pb)2212 single crystals. The highest Jc at 20 K observed were ~0.85 MAcm-2 in self-field and ~0.1 MAcm-2 under 5 T with H // c. The dilute Y and Ludoping is considered to introduce locally lattice-distorted regions acting as effective pinning sites up to high fields.

  5. Using M and S to Improve Human Decision Making and Achieve Effective Problem Solving in an International Environment

    NASA Technical Reports Server (NTRS)

    Christie, Vanessa L.; Landess, David J.

    2012-01-01

    In the international arena, decision makers are often swayed away from fact-based analysis by their own individual cultural and political bias. Modeling and Simulation-based training can raise awareness of individual predisposition and improve the quality of decision making by focusing solely on fact vice perception. This improved decision making methodology will support the multinational collaborative efforts of military and civilian leaders to solve challenges more effectively. The intent of this experimental research is to create a framework that allows decision makers to "come to the table" with the latest and most significant facts necessary to determine an appropriate solution for any given contingency.

  6. Achieving a culture of continuous improvement by adopting the principles of self-assessment and business excellence.

    PubMed

    Jackson, S

    1999-01-01

    Following a brief description of the inception of self-assessment and the European Foundation for Quality business excellence model, this article describes how one clinical directorate in an NHS Trust used the principles of both to secure a culture of continuous improvement. The journey from a mainly hierarchical, bureaucratic, individualist culture to one where the norms, values and beliefs reflected teamwork, involvement and empowerment is described. The highs, lows and learning points are all included, in an attempt to enlighten other healthcare organisations considering the benefits and pitfalls of using the business excellence model to improve the quality of their healthcare delivery. PMID:10537858

  7. Boron-doped bismuth oxybromide microspheres with enhanced surface hydroxyl groups: Synthesis, characterization and dramatic photocatalytic activity.

    PubMed

    Liu, ZhangSheng; Liu, JinLong; Wang, HaiYang; Cao, Gang; Niu, JiNan

    2016-02-01

    B-doped BiOBr photocatalysts were successfully synthesized via a facile solvothermal method with boric acid used as boron source. As-obtained products consist of novel hierarchical microspheres, whose nanosheet building units were formed by nanoparticles splicing. They showed dramatic photocatalytic efficiency toward the degradation of Rhodamine B (RhB) and phenol under the visible-light irradiation and the highest activity was achieved by 0.075B-BiOBr. The enhanced photocatalytic activity could be attributed to the enriched surface hydroxyl groups on B-doped BiOBr samples, which not only improved the adsorption of pollutant on the photocatalyst but also promoted the separation of photogenerated electron-hole pairs. In addition, it was found that the main reactive species responsible for the degradation of organic pollutant were h(+) and O2(-) radicals, instead of OH radicals. PMID:26590875

  8. Evaluation and capacity building to improve precollege science and mathematics achievement in the US: 10 CFR, Part 605. Technical progress report, June--December 1992

    SciTech Connect

    Not Available

    1992-12-31

    The National Center for Improving Science Education has undertaken activities to achieve evaluation goals for DOE`s Precollege programs: develop means to determine program quality; develop means for determining the contribution of DOE precollege programs to both teacher enhancement and student achievement; provide evaluation designs and instruments and reports of program quality and impact; and strengthen both DOE`s and the Labs` capacity to do both short- and long-term planning as well as deliver effective programs and evaluation. Appendices include evaluation/technical assistance report, profiling teacher research participation and teacher development programs, teacher surveys, impact assessment design, and teacher research participation programs anecdotes for 8 labs.

  9. A Project-Based Digital Storytelling Approach for Improving Students' Learning Motivation, Problem-Solving Competence and Learning Achievement

    ERIC Educational Resources Information Center

    Hung, Chun-Ming; Hwang, Gwo-Jen; Huang, Iwen

    2012-01-01

    Although project-based learning is a well-known and widely used instructional strategy, it remains a challenging issue to effectively apply this approach to practical settings for improving the learning performance of students. In this study, a project-based digital storytelling approach is proposed to cope with this problem. With a…

  10. The Impact of School Improvement Grants on Achievement: Plans for a National Evaluation Using a Regression Discontinuity Design

    ERIC Educational Resources Information Center

    Deke, John; Dragoset, Lisa

    2015-01-01

    Does receipt of School Improvement Grants (SIG) funding to implement a school intervention model have an impact on outcomes for low-performing schools? This study answers this question using a regression discontinuity design (RDD) that exploits cutoff values on the continuous variables used to define SIG eligibility tiers, comparing outcomes in…

  11. Taking Off! Sharing State-Level Accountability Strategies. Using Academic and Vocational Accountability Strategies To Improve Student Achievement.

    ERIC Educational Resources Information Center

    Rahn, Mikala L.; O'Driscoll, Patricia; Hudecki, Phyllis

    This document shares lessons learned related to states' strategies to improve accountability. Case studies describe promising practices or particular strategies within an accountability system that have operationalized six standards identified by the National Association of State Boards of Education. The introduction discusses accountability and…

  12. Do Incentive-Based Programs Improve Teacher Quality and Student Achievement? An Analysis of Implementation in 12 Urban Charter Schools

    ERIC Educational Resources Information Center

    Kaimal, Girija; Jordan, Will J.

    2016-01-01

    Context: Policymakers have increasingly advocated for incentive-based approaches for improving urban schools. Purpose of the study: Few studies have examined the implementation of incentive based approaches in the urban charter school context. This paper presents research findings from a 4-year longitudinal study of the implementation of a…

  13. Performance Incentives to Improve Community College Completion: Learning from Washington State's Student Achievement Initiative. A State Policy Brief

    ERIC Educational Resources Information Center

    Shulock, Nancy; Jenkins, Davis

    2011-01-01

    Amid growing signs of America's weakening position in the global economy, federal and state policymakers and major foundations have set ambitious goals for increasing postsecondary attainment in the United States. Given changing U.S. demographics, it has become clear that these national goals are attainable only with vastly improved outcomes among…

  14. Yes We Can! Improving Urban Schools through Innovative Educational Reform. Contemporary Perspectives on Access, Equity, and Achievement

    ERIC Educational Resources Information Center

    Howell, Leanne L., Ed.; Lewis, Chance W., Ed.; Carter, Norvella, Ed.

    2011-01-01

    Yes We Can: Improving Urban Schools through Innovative Educational Reform is a empirically-based book on urban education reform to not only proclaim that hope is alive for urban schools, but to also produce a body of literature that examines current practices and then offer practical implications for all involved in this arduous task. This book is…

  15. Achieving Their Potential

    ERIC Educational Resources Information Center

    Prouty, Sally T.

    2009-01-01

    Seventy-five years ago, Franklin D. Roosevelt took two crises--a decayed environment and wide unemployment--and combined them to form a single success: the Civilian Conservation Corps (CCC). In the CCC three million young unemployed men dramatically improved the nation's infrastructure. The CCC gave young Americans living in poverty hope. This…

  16. Monitoring Hip and Elbow Dysplasia Achieved Modest Genetic Improvement of 74 Dog Breeds over 40 Years in USA

    PubMed Central

    Zhang, Xu; Zhao, Qian; Todhunter, Rory J.; Zhang, Zhiwu

    2013-01-01

    Hip (HD) and Elbow Dysplasia (ED) are two common complex developmental disorders of dogs. In order to decrease their prevalence and severity, the Orthopedic Foundation for Animals (OFA) has a voluntary registry of canine hip and elbow conformation certified by boarded radiologists. However, the voluntarily reports have been severely biased against exposing dogs with problems, especially at beginning period. Fluctuated by additional influential factors such as age, the published raw scores barely showed trends of improvement. In this study, we used multiple-trait mixed model to simultaneously adjust these factors and incorporate pedigree to derive Estimated Breeding Values (EBV). A total of 1,264,422 dogs from 74 breeds were evaluated for EBVs from 760,455 hip scores and 135,409 elbow scores. These EBVs have substantially recovered the reporting bias and the other influences. Clear and steady trends of genetic improvement were observed over the 40 years since 1970. The total genetic improvements were 16.4% and 1.1% of the phenotypic standard deviation for HD and ED, respectively. The incidences of dysplasia were 0.83% and 2.08%, and the heritabilities were estimated as 0.22 and 0.17 for hip and elbow scores, respectively. The genetic correlation between them was 0.12. We conclude that EBV is more effective than reporting raw phenotype. The weak genetic correlation suggested that selection based on hip scores would also slightly improve elbow scores but it is necessary to allocate effort toward improvement of elbow scores alone. PMID:24124555

  17. Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA.

    PubMed

    Hou, Yali; Wang, Yachun; Lu, Xuemei; Zhang, Xu; Zhao, Qian; Todhunter, Rory J; Zhang, Zhiwu

    2013-01-01

    Hip (HD) and Elbow Dysplasia (ED) are two common complex developmental disorders of dogs. In order to decrease their prevalence and severity, the Orthopedic Foundation for Animals (OFA) has a voluntary registry of canine hip and elbow conformation certified by boarded radiologists. However, the voluntarily reports have been severely biased against exposing dogs with problems, especially at beginning period. Fluctuated by additional influential factors such as age, the published raw scores barely showed trends of improvement. In this study, we used multiple-trait mixed model to simultaneously adjust these factors and incorporate pedigree to derive Estimated Breeding Values (EBV). A total of 1,264,422 dogs from 74 breeds were evaluated for EBVs from 760,455 hip scores and 135,409 elbow scores. These EBVs have substantially recovered the reporting bias and the other influences. Clear and steady trends of genetic improvement were observed over the 40 years since 1970. The total genetic improvements were 16.4% and 1.1% of the phenotypic standard deviation for HD and ED, respectively. The incidences of dysplasia were 0.83% and 2.08%, and the heritabilities were estimated as 0.22 and 0.17 for hip and elbow scores, respectively. The genetic correlation between them was 0.12. We conclude that EBV is more effective than reporting raw phenotype. The weak genetic correlation suggested that selection based on hip scores would also slightly improve elbow scores but it is necessary to allocate effort toward improvement of elbow scores alone. PMID:24124555

  18. Improving educational achievement and anaemia of school children: design of a cluster randomised trial of school-based malaria prevention and enhanced literacy instruction in Kenya

    PubMed Central

    2010-01-01

    Background Improving the health of school-aged children can yield substantial benefits for cognitive development and educational achievement. However, there is limited experimental evidence on the benefits of school-based malaria prevention or how health interventions interact with other efforts to improve education quality. This study aims to evaluate the impact of school-based malaria prevention and enhanced literacy instruction on the health and educational achievement of school children in Kenya. Design A factorial, cluster randomised trial is being implemented in 101 government primary schools on the coast of Kenya. The interventions are (i) intermittent screening and treatment of malaria in schools by public health workers and (ii) training workshops and support for teachers to promote explicit and systematic literacy instruction. Schools are randomised to one of four groups: receiving either (i) the malaria intervention alone; (ii) the literacy intervention alone; (iii) both interventions combined; or (iv) control group where neither intervention is implemented. Children from classes 1 and 5 are randomly selected and followed up for 24 months. The primary outcomes are educational achievement and anaemia, the hypothesised mediating variables through which education is affected. Secondary outcomes include malaria parasitaemia, school attendance and school performance. A nested process evaluation, using semi-structured interviews, focus group discussion and a stakeholder analysis will investigate the community acceptability, feasibility and cost-effectiveness of the interventions. Discussion Across Africa, governments are committed to improve health and education of school-aged children, but seek clear policy and technical guidance as to the optimal approach to address malaria and improved literacy. This evaluation will be one of the first to simultaneously evaluate the impact of health and education interventions in the improvement of educational achievement

  19. Child abuse and neglect in Turkey: professional, governmental and non-governmental achievements in improving the national child protection system.

    PubMed

    Akco, Seda; Dagli, Tolga; Inanici, Mehmet Akif; Kaynak, Hatice; Oral, Resmiye; Sahin, Figen; Sofuoglu, Zeynep; Ulukol, Betul

    2013-11-01

    Since ratification of the United Nations Convention on the Rights of the Child in 1995, significant efforts were made in Turkey to improve protection of children from abuse and neglect. The government took steps to amend relevant laws. Several state departments recognized the need for professional in-service training of relevant governmental agency staff. University hospitals established numerous hospital-based multidisciplinary child protection centres. The government established an Interministerial Higher Council, which has been overseeing the foundation of 13 child advocacy centres for a multidisciplinary and interagency response to child sexual abuse. In addition to undertaking research, non-governmental organizations contributed to this process by instituting professional and public education. These ground-breaking developments in the last decade give promise of even further improvement in the national child protection system from investigative, child protective and rehabilitative perspectives. PMID:24070409

  20. Sensitivity improvement of an electrical sensor achieved by control of biomolecules based on the negative dielectrophoretic force.

    PubMed

    Kim, Hye Jin; Kim, Jinsik; Yoo, Yong Kyoung; Lee, Jeong Hoon; Park, Jung Ho; Hwang, Kyo Seon

    2016-11-15

    Effective control of nano-scale biomolecules can enhance the sensitivity and limit of detection of an interdigitated microelectrode (IME) sensor. Manipulation of the biomolecules by dielectrophoresis (DEP), especially the negative DEP (nDEP) force, so that they are trapped between electrodes (sensing regions) was predicted to increase the binding efficiency of the antibody and target molecules, leading to a more effective reaction. To prove this concept, amyloid beta 42 (Aβ42) and prostate specific antigen (PSA) protein were respectively trapped between the sensing region owing to the nDEP force under 5V and 0.05V, which was verified with COMSOL simulation. Using the simulation value, the resistance change (ΔR/Rb) of the IME sensor from the specific antibody-antigen reaction of the two biomolecules and the change in fluorescence intensity were compared in the reference (pDEP) and nDEP conditions. The ΔR/Rb value improved by about 2-fold and 1.66-fold with nDEP compared to the reference condition with various protein concentrations, and these increases were confirmed with fluorescence imaging. Overall, nDEP enhanced the detection sensitivity for Aβ42 and PSA by 128% and 258%, respectively, and the limit of detection improved by up to 2-orders of magnitude. These results prove that DEP can improve the biosensor's performance. PMID:27449966

  1. Human ergology that promotes participatory approach to improving safety, health and working conditions at grassroots workplaces: achievements and actions.

    PubMed

    Kawakami, Tsuyoshi

    2011-12-01

    Participatory approaches are increasingly applied to improve safety, health and working conditions of grassroots workplaces in Asia. The core concepts and methods in human ergology research such as promoting real work life studies, relying on positive efforts of local people (daily life-technology), promoting active participation of local people to identify practical solutions, and learning from local human networks to reach grassroots workplaces, have provided useful viewpoints to devise such participatory training programmes. This study was aimed to study and analyze how human ergology approaches were applied in the actual development and application of three typical participatory training programmes: WISH (Work Improvement for Safe Home) with home workers in Cambodia, WISCON (Work Improvement in Small Construction Sites) with construction workers in Thailand, and WARM (Work Adjustment for Recycling and Managing Waste) with waste collectors in Fiji. The results revealed that all the three programmes, in the course of their developments, commonly applied direct observation methods of the work of target workers before devising the training programmes, learned from existing local good examples and efforts, and emphasized local human networks for cooperation. These methods and approaches were repeatedly applied in grassroots workplaces by taking advantage of their the sustainability and impacts. It was concluded that human ergology approaches largely contributed to the developments and expansion of participatory training programmes and could continue to support the self-help initiatives of local people for promoting human-centred work. PMID:25665213

  2. Can Community and School-Based Supports Improve the Achievement of First-Generation Immigrant Children Attending High-Poverty Schools?

    PubMed

    Dearing, Eric; Walsh, Mary E; Sibley, Erin; Lee-St John, Terry; Foley, Claire; Raczek, Anastacia E

    2016-05-01

    Using a quasi-experimental design, the effects of a student support intervention were estimated for the math and reading achievement of first-generation immigrant children (n = 667, M = 11.05 years of age) attending high-poverty, urban elementary schools. The intervention was designed to help schools identify developmental strengths and barriers to learning and, in turn, connect children to community and school supports aligned with their strengths and needs. By exploiting within-school changes in the implementation of the intervention, the present study revealed statistically and practically significant treatment effects indicating improvements in math and reading achievement at the end of elementary school. In addition, the intervention appears to considerably narrow achievement gaps between English language learners and immigrant children proficient in English. PMID:27028490

  3. Indirect Effects of the Family Check-Up on School-Age Academic Achievement Through Improvements in Parenting in Early Childhood

    PubMed Central

    Brennan, Lauretta M.; Shelleby, Elizabeth C.; Shaw, Daniel S.; Gardner, Frances; Dishion, Thomas J.; Wilson, Melvin

    2013-01-01

    This project examined the hypothesis that the impact of the Family Check-Up on parent use of positive behavior support would indirectly improve academic achievement scores at school age. The study included a sample of 731 high-risk families recruited from Women, Infant, and Children Supplemental Nutrition Program settings in 3 geographically distinct areas. The results demonstrated that changes in positive parenting between the child ages of 2 and 3 were associated with higher scores on children’s school-age academic achievement, as measured by the Woodcock–Johnson III (W-J) Academic Skills composite. Moreover, structural equation modeling revealed that random assignment to the intervention was associated with higher levels of children’s academic achievement at age 5 and age 7.5 indirectly, through greater increases in parents’ use of positive behavior support in intervention families than in control families. Results are discussed with respect to the potential of a brief parenting intervention for improving parenting practices that promote academic achievement up to 5 years later. The results have promising implications for efforts to promote child adaptation in the school environment. PMID:24319295

  4. The effectiveness of a standards-based integrated chemistry and mathematics curriculum on improving the academic achievement in chemistry for high school students in Southern California

    NASA Astrophysics Data System (ADS)

    Mupanduki, Blessing T.

    The purpose of this study was to determine whether integrating chemistry and mathematics curricula and teaching practices significantly improves academic achievement in chemistry among high school students in Southern California. The study was conducted during the 2008--2009 academic year. A quasi-experimental research design was used to explore the effects of a standards-based integrated chemistry and mathematics curriculum (Integrated CHEMAT) and teaching practices on student academic achievement when compared to a traditional standards-based chemistry curriculum (Regular CHEM) and teaching practices. Academic achievement was based on a researcher-created Chemistry Achievement Assessment (CHAAS). The sample population involved in the research included 136 high school chemistry students attending high school in a Southern California rural school district. The research involved 2 groups of 68 students each: the experimental group and the control group. The data were analyzed using SPSS independent samples t-test, one-way multivariate analysis of covariance (MANCOVA), and profile analysis. Statistical significance was determined at the .05 and .001 levels. Significant differences were found when analyzing the effects of the standards-based integrated chemistry and mathematics curriculum and teaching practices. All 3 statistical analysis procedures (the independent samples t-test, MANCOVA, and profile analysis) indicated that students in the integrated CHEMAT program scored significantly higher than the students in the regular CHEM program in achievement scores based on the results of the CHAAS.

  5. Achieving equity in HIV-treatment outcomes: can social protection improve adolescent ART-adherence in South Africa?

    PubMed Central

    Cluver, L. D.; Toska, E.; Orkin, F. M.; Meinck, F.; Hodes, R.; Yakubovich, A. R.; Sherr, L.

    2016-01-01

    ABSTRACT Low ART-adherence amongst adolescents is associated with morbidity, mortality and onward HIV transmission. Reviews find no effective adolescent adherence-promoting interventions. Social protection has demonstrated benefits for adolescents, and could potentially improve ART-adherence. This study examines associations of 10 social protection provisions with adherence in a large community-based sample of HIV-positive adolescents. All 10–19-year-olds ever ART-initiated in 53 government healthcare facilities in a health district of South Africa’s Eastern Cape were traced and interviewed in 2014–2015 (n = 1175 eligible). About 90% of the eligible sample was included (n = 1059). Social protection provisions were “cash/cash in kind”: government cash transfers, food security, school fees/materials, school feeding, clothing; and “care”: HIV support group, sports groups, choir/art groups, positive parenting and parental supervision/monitoring. Analyses used multivariate regression, interaction and marginal effects models in SPSS and STATA, controlling for socio-demographic, HIV and healthcare-related covariates. Findings showed 36% self-reported past-week ART non-adherence (<95%). Non-adherence was associated with increased opportunistic infections (p = .005, B .269, SD .09), and increased likelihood of detectable viral load at last test (>75 copies/ml) (aOR 1.98, CI 1.1–3.45). Independent of covariates, three social protection provisions were associated with reduced non-adherence: food provision (aOR .57, CI .42–.76, p < .001); HIV support group attendance (aOR .60, CI .40–.91, p < .02), and high parental/caregiver supervision (aOR .56, CI .43–.73, p < .001). Combination social protection showed additive benefits. With no social protection, non-adherence was 54%, with any one protection 39–41%, with any two social protections, 27–28% and with all three social protections, 18%. These results demonstrate that social protection provisions

  6. Achieving equity in HIV-treatment outcomes: can social protection improve adolescent ART-adherence in South Africa?

    PubMed

    Cluver, L D; Toska, E; Orkin, F M; Meinck, F; Hodes, R; Yakubovich, A R; Sherr, L

    2016-03-01

    Low ART-adherence amongst adolescents is associated with morbidity, mortality and onward HIV transmission. Reviews find no effective adolescent adherence-promoting interventions. Social protection has demonstrated benefits for adolescents, and could potentially improve ART-adherence. This study examines associations of 10 social protection provisions with adherence in a large community-based sample of HIV-positive adolescents. All 10-19-year-olds ever ART-initiated in 53 government healthcare facilities in a health district of South Africa's Eastern Cape were traced and interviewed in 2014-2015 (n = 1175 eligible). About 90% of the eligible sample was included (n = 1059). Social protection provisions were "cash/cash in kind": government cash transfers, food security, school fees/materials, school feeding, clothing; and "care": HIV support group, sports groups, choir/art groups, positive parenting and parental supervision/monitoring. Analyses used multivariate regression, interaction and marginal effects models in SPSS and STATA, controlling for socio-demographic, HIV and healthcare-related covariates. Findings showed 36% self-reported past-week ART non-adherence (<95%). Non-adherence was associated with increased opportunistic infections (p = .005, B .269, SD .09), and increased likelihood of detectable viral load at last test (>75 copies/ml) (aOR 1.98, CI 1.1-3.45). Independent of covariates, three social protection provisions were associated with reduced non-adherence: food provision (aOR .57, CI .42-.76, p < .001); HIV support group attendance (aOR .60, CI .40-.91, p < .02), and high parental/caregiver supervision (aOR .56, CI .43-.73, p < .001). Combination social protection showed additive benefits. With no social protection, non-adherence was 54%, with any one protection 39-41%, with any two social protections, 27-28% and with all three social protections, 18%. These results demonstrate that social protection provisions, particularly combinations of "cash

  7. General chemistry courses that can affect achievement: An action research study in developing a plan to improve undergraduate chemistry courses

    NASA Astrophysics Data System (ADS)

    Shweikeh, Eman

    Over the past 50 years, considerable research has been dedicated to chemistry education. In evaluating principal chemistry courses in higher education, educators have noted the learning process for first-year general chemistry courses may be challenging. The current study investigated perceptions of faculty, students and administrators on chemistry education at three institutions in Southern California. Via action research, the study sought to develop a plan to improve student engagement in general chemistry courses. A mixed method was utilized to analyze different perceptions on key factors determining the level of commitment and engagement in general chemistry education. The approach to chemistry learning from both a faculty and student perspective was examined including good practices, experiences and extent of active participation. The research study considered well-known measures of effective education with an emphasis on two key components: educational practices and student behavior. Institutional culture was inclusively assessed where cognitive expectations of chemistry teaching and learning were communicated. First, the extent in which faculty members are utilizing the "Seven Principles for Good Practice in Undergraduate Education" in their instruction was explored. Second, student attitudes and approaches toward chemistry learning were examined. The focus was on investigating student understanding of the learning process and the structure of chemistry knowledge. The seven categories used to measure students' expectations for learning chemistry were: effort, concepts, math link, reality link, outcome, laboratory, and visualization. This analysis represents the views of 16 faculty and 140 students. The results validated the assertion that students need some competencies and skills to tackle the challenges of the chemistry learning process to deeply engage in learning. A mismatch exists between the expectations of students and those of the faculty

  8. Injection of Xenopus eggs before activation, achieved by control of extracellular factors, improves plasmid DNA replication after activation.

    PubMed

    Wangh, L J

    1989-05-01

    Injection of molecular probes into unfertilized Xenopus eggs requires suppression of activation. But the unfertilized egg is poised for activity, and pricking, like sperm penetration, triggers the start of the first cell cycle. Methods of suppressing activation generally rely on introduction of drugs into the cell, but some of these techniques are irreversible. I report here that injection without activation can also be accomplished by simply limiting extracellular free Ca2+ to 1-2 microM. The site of injection heals, but the cortex does not contract. Gentle modification of the vitelline envelope, which causes it to become tougher, improves the rate of healing to about 100%. Healed eggs are stable for hours and can be activated when needed. Injection of a plasmid derived from type 1 bovine papilloma virus revealed that replication occurs only after activation, but preloading the DNA markedly increased the efficiency of first-round replication. DNA interaction with the unactivated egg cytoplasm may therefore be required for efficient replication of exogenous DNA. The new procedures described here are likely to be of general utility. PMID:2559091

  9. Parahydrogen and Synthesis Allow Dramatically Enhanced Nuclear Alignment

    NASA Astrophysics Data System (ADS)

    Bowers, Clifford Russell

    The PASADENA effect is a method for transient high-sensitivity proton spin-labelling by molecular addition of dihydrogen. When the parahydrogen mole fraction differs from the high-temperature limit of 1/4, this population difference constitutes a form of spin order which can be converted to magnetization observable by NMR. Large NMR signals are observed, if subsequent to the hydrogen addition, the two protons experience magnetic inequivalence and spin -spin coupling and if observation is made before spin-lattice relaxation restores the equilibrium spin order. The analogous effect for D_2 is also possible. The kinetic mechanisms of the homogeneous hydrogenation catalysts which permit the realization of the PASADENA effect have been the target of the experimental applications. Rates determined in PASADENA studies pertain to the active catalytic species, since only these molecules can contribute to the enhanced signals from which all kinetic inferences are made. The sensitivity enhancement has also led to the identification of a novel intermediate in the mechanism for the Rh(DIPHOS)^+ catalyzed hydrogenation of styrene. The rate of conversion of this species into product and starting material has been studied using two -dimensional NMR. The dramatically improved sensitivity should make it possible to observe key catalytic intermediates which do not build up in sufficient quantity to allow detection by conventional NMR arising from Curie-Law magnetization. The study of surface sites which bind pairwise with H_2 is also a potentially fruitful area for future experimental work. The ambient temperature NMR spectroscopy of surfaces is not often feasible due to sensitivity limitations. Simulations have been performed using typical shift and coupling parameters in an effort to characterize the enhanced lineshapes which can be expected. The inverse of the PASADENA effect has also been proposed, whereby the spin order of a molecule containing hydrogen is probed by measuring

  10. Use of Dramatic Enquiry to Explore Controversies in Science

    ERIC Educational Resources Information Center

    Phillipson, Neil; Poad, Gordon

    2010-01-01

    With the increasing prominence of "How science works" in science courses in England and the imperative of equipping students to engage with the controversies thrown up by the advance of science, science departments need new teaching strategies. Here we describe the application of "Dramatic Enquiry" to GCSE science. The project, developed by…

  11. Dramatic Play: Root Meaning of Drama/Theatre.

    ERIC Educational Resources Information Center

    Koste, Virginia Glasgow

    The processes involved in drama and the dramatic play of children are essentially the same in that they rely on an imitation of nature, involve a transformation of reality through imagination, connect seemingly irrelevant elements creatively, and bring a temporary, limited order to an emotional experience. When child's play is used as a basis for…

  12. Assessment to Make "Dramatic Advance;" Coherency, Comprehensiveness Key

    ERIC Educational Resources Information Center

    Armistead, Lew

    2010-01-01

    Assessment in America's high schools is about to undergo its most dramatic advance in decades, according to a policy brief released in February by the Alliance for Excellent Education (AEE), a Washington, DC, based organization devoted to promoting high school transformation. "There is widespread concern that the most prominent assessments…

  13. Piaget in Performance: The Role of "Games" in Creative Dramatics.

    ERIC Educational Resources Information Center

    Ratliff, Gerald Lee

    Jean Piaget's theories of child development and the nature of intelligence are adapted to creative dramatics in this description of two games for children aged 6 through 12. The first game discussed incorporates a "touchy-feely box," a cardboard construction with openings on two sides so that a child may reach inside, select, and describe an…

  14. Burke Bingo: Using Active Learning to Introduce Dramatism

    ERIC Educational Resources Information Center

    Krueger, Ben

    2011-01-01

    Kenneth Burke is typically regarded as the single most significant figure in 20th-century rhetorical studies. Undergraduate textbooks in rhetorical criticism, rhetorical theory, and communication theory typically include coverage of Burke's theory of dramatism. In this article, the author describes a classroom activity dubbed "Burke Bingo" that…

  15. Celebrating Diversity through Northeastern Asian Children's Literature and Dramatic Productions.

    ERIC Educational Resources Information Center

    Richardson, Maurine V.; And Others

    At the University of South Dakota, as part of a campus-wide celebration of diversity focused on northeastern Asia (China, Japan, Korea), undergraduate and graduate Children's Literature classes participated by locating relevant literature and presenting them dramatically. Students were divided into six small cooperative groups. Each group chose a…

  16. Astronaut to Zoologist: Changing the Dramatic Play Area!

    ERIC Educational Resources Information Center

    Brouette, Scott J.

    Changing the dramatic play area in a child care setting promotes creativity and gives children the chance to experience a place they may never experience in real life. Whenever possible, the children should be involved in the process of changing the area, by moving furniture and exchanging props, as well as brainstorming ideas for changes. The…

  17. Frost Bite: A Dramatic Tale of Research in Aesthetic Education

    ERIC Educational Resources Information Center

    Hirsch, Miriam

    2008-01-01

    This article follows the author's research on the integration of an aesthetic arts initiative in a private elementary school with an established traditional arts program. The narrative describes the sequence of events, interpersonal interactions, and learning experiences in the format of a full-length dramatic performance. Informed by Ben Peretz's…

  18. Soaps and Suspicious Activity: Dramatic Experiences in British Classrooms.

    ERIC Educational Resources Information Center

    Ferree, Angela M.

    2001-01-01

    Offers examples of dramatic experiences (student produced soap operas) in two classrooms in British comprehensive secondary schools. Concludes that students in other countries would find such experiences as meaningful and enjoyable as their British counterparts. Notes that the two teachers managed to be flexible, appropriating effective…

  19. Windows into Children's Thinking: A Guide to Storytelling and Dramatization

    ERIC Educational Resources Information Center

    Wright, Cheryl; Bacigalupa, Chiara; Black, Tyler; Burton, Michael

    2008-01-01

    Telling and dramatizing stories is an increasingly popular addition to the preschool curriculum, largely due to the attention this activity has received through the writings of Vivian Paley (Bad guys don't have birthdays: fantasy play at four. The University of Chicago Press, Chicago, 1988; The boy who would be a helicopter: the uses of…

  20. Inverting the Achievement Pyramid

    ERIC Educational Resources Information Center

    White-Hood, Marian; Shindel, Melissa

    2006-01-01

    Attempting to invert the pyramid to improve student achievement and increase all students' chances for success is not a new endeavor. For decades, educators have strategized, formed think tanks, and developed school improvement teams to find better ways to improve the achievement of all students. Currently, the No Child Left Behind Act (NCLB) is…

  1. Achieving change in primary care—effectiveness of strategies for improving implementation of complex interventions: systematic review of reviews

    PubMed Central

    Lau, Rosa; Stevenson, Fiona; Ong, Bie Nio; Dziedzic, Krysia; Treweek, Shaun; Eldridge, Sandra; Everitt, Hazel; Kennedy, Anne; Qureshi, Nadeem; Rogers, Anne; Peacock, Richard; Murray, Elizabeth

    2015-01-01

    Objective To identify, summarise and synthesise available literature on the effectiveness of implementation strategies for optimising implementation of complex interventions in primary care. Design Systematic review of reviews. Data sources MEDLINE, EMBASE, CINAHL, Cochrane Library and PsychINFO were searched, from first publication until December 2013; the bibliographies of relevant articles were screened for additional reports. Eligibility criteria for selecting studies Eligible reviews had to (1) examine effectiveness of single or multifaceted implementation strategies, (2) measure health professional practice or process outcomes and (3) include studies from predominantly primary care in developed countries. Two reviewers independently screened titles/abstracts and full-text articles of potentially eligible reviews for inclusion. Data synthesis Extracted data were synthesised using a narrative approach. Results 91 reviews were included. The most commonly evaluated strategies were those targeted at the level of individual professionals, rather than those targeting organisations or context. These strategies (eg, audit and feedback, educational meetings, educational outreach, reminders) on their own demonstrated a small to modest improvement (2–9%) in professional practice or behaviour with considerable variability in the observed effects. The effects of multifaceted strategies targeted at professionals were mixed and not necessarily more effective than single strategies alone. There was relatively little review evidence on implementation strategies at the levels of organisation and wider context. Evidence on cost-effectiveness was limited and data on costs of different strategies were scarce and/or of low quality. Conclusions There is a substantial literature on implementation strategies aimed at changing professional practices or behaviour. It remains unclear which implementation strategies are more likely to be effective than others and under what conditions

  2. Enhancement of filterability in MBR achieved by improvement of supernatant and floc characteristics via filter aids addition.

    PubMed

    Ji, Jing; Qiu, Jiangping; Wong, Fook-sin; Li, Yaozhong

    2008-08-01

    Reduction of membrane fouling in membrane bioreactors (MBR) by addition of three typical filter aids (aluminum sulfate (Al(2)(SO(4))(3)), polymeric ferric sulfate (PFS) and Chitosan) was investigated. The effects of filter aids on membrane pore blocking, gel layer and cake layer resistance were analyzed respectively. Significant improvement of the sustainable filtration was demonstrated in the filter aids added MBRs. The membrane fouling rate of the MBRs operated under 20L/m(2)h flux was in the order of Control MBR (no filter aid added)>Al(2)(SO(4))(3) added MBR>Chitosan added MBR>PFS added MBR. Membrane inner fouling due to pore blocking was analyzed by means of Fourier-transform infrared microscope (FTIR). Compared to the control MBR, significantly low protein and carbohydrate concentrations were measured in the membranes of the filter aids added MBRs, indicating that filter aids could effectively alleviate membrane pore blocking. Gel Permeation Chromatography (GPC) analysis suggested that both the concentration and molecular weight distribution of the macromolecules in supernatant play an important role in gel layer formation and loss of membrane porosity. The reduction of fouling rate in the filter aids added MBRs could be attributed to lower concentration and reduction in molecular weight of macromolecules in supernatant. The specific cake resistance (alpha(c)), mean floc size (d(p)) and fractal dimension of the flocs (df) in the filter aids added MBRs were also investigated. It was demonstrated that alpha(c) decreased with the increase of d(p) and with the decrease of df, which is in consistent with the model prediction. PMID:18694586

  3. Achieving a "Grand Convergence" in Global Health by 2035: Rwanda Shows the Way Comment on "Improving the World's Health Through the Post-2015 Development Agenda: Perspectives From Rwanda".

    PubMed

    Yamey, Gavin; Fewer, Sara; Beyeler, Naomi

    2015-01-01

    Global Health 2035, the report of The Lancet Commission on Investing in Health, laid out a bold, highly ambitious framework for making rapid progress in improving global public health outcomes. It showed that with the right health investments, the international community could achieve a "grand convergence" in global health-a reduction in avertable infectious, maternal, and child deaths down to universally low levels-within a generation. Rwanda's success in rapidly reducing such deaths over the last 20 years shows that convergence is feasible. Binagwaho and Scott have argued that 5 lessons from this success are the importance of equity, quality health services, evidence-informed policy, intersectoral collaboration, and effective collaboration between countries and multilateral agencies. This article re-examines these lessons through the lens of the Global Health 2035 report to analyze how the experience in Rwanda might be generalized for other countries to making progress towards achieving a grand convergence. PMID:26673345

  4. Permeability Enhancers Dramatically Increase Zanamivir Absolute Bioavailability in Rats: Implications for an Orally Bioavailable Influenza Treatment

    PubMed Central

    Holmes, Eric H.; Devalapally, Harikrishna; Li, Libin; Perdue, Michael L.; Ostrander, Gary K.

    2013-01-01

    We have demonstrated that simple formulations composed of the parent drug in combination with generally regarded as safe (GRAS) permeability enhancers are capable of dramatically increasing the absolute bioavailability of zanamivir. This has the advantage of not requiring modification of the drug structure to promote absorption, thus reducing the regulatory challenges involved in conversion of an inhaled to oral route of administration of an approved drug. Absolute bioavailability increases of up to 24-fold were observed when Capmul MCM L8 (composed of mono- and diglycerides of caprylic/capric acids in glycerol) was mixed with 1.5 mg of zanamivir and administered intraduodenally to rats. Rapid uptake (tmax of 5 min) and a Cmax of over 7200 ng/mL was achieved. Variation of the drug load or amount of enhancer demonstrated a generally linear variation in absorption, indicating an ability to optimize a formulation for a desired outcome such as a targeted Cmax for enzyme saturation. No absorption enhancement was observed when the enhancer was given 2 hr prior to drug administration, indicating, in combination with the observed tmax, that absorption enhancement is temporary. This property is significant and aligns well with therapeutic applications to limit undesirable drug-drug interactions, potentially due to the presence of other poorly absorbed polar drugs. These results suggest that optimal human oral dosage forms of zanamivir should be enteric-coated gelcaps or softgels for intraduodenal release. There continues to be a strong need and market for multiple neuraminidase inhibitors for influenza treatment. Creation of orally available formulations of inhibitor drugs that are currently administered intravenously or by inhalation would provide a significant improvement in treatment of influenza. The very simple GRAS formulation components and anticipated dosage forms would require low manufacturing costs and yield enhanced convenience. These results are being utilized

  5. Dramatic changes in electronic structure revealed by fractionally charged nuclei

    SciTech Connect

    Cohen, Aron J.; Mori-Sánchez, Paula

    2014-01-28

    Discontinuous changes in the electronic structure upon infinitesimal changes to the Hamiltonian are demonstrated. These are revealed in one and two electron molecular systems by full configuration interaction (FCI) calculations when the realm of the nuclear charge is extended to be fractional. FCI electron densities in these systems show dramatic changes in real space and illustrate the transfer, hopping, and removal of electrons. This is due to the particle nature of electrons seen in stretched systems and is a manifestation of an energy derivative discontinuity at constant number of electrons. Dramatic errors of density functional theory densities are seen in real space as this physics is missing from currently used approximations. The movements of electrons in these simple systems encapsulate those in real physical processes, from chemical reactions to electron transport and pose a great challenge for the development of new electronic structure methods.

  6. Dramatic Resolution of an Unresectable Giant Basal Cell Carcinoma Treated with Intensity-Modulated Radiation Therapy (IMRT) - A Case Report

    PubMed Central

    Wandrey, Narine; Chen, Tiffany

    2015-01-01

    A 59-year-old man presented with an unresectable bulky giant basal cell carcinoma on his upper back. A trial of chemotherapy did not help relieve his symptoms or reduce the tumor. He was referred for and received definitive radiation therapy via IMRT with dramatic regression. The patient had been unable to lie on his back for many years but currently can sleep comfortably on his back without pain, which has dramatically improved his quality of life. PMID:26848409

  7. Does Homework Really Improve Achievement?

    ERIC Educational Resources Information Center

    Costley, Kevin C.

    2013-01-01

    Should public school teachers assign daily homework? Should school districts have policies requiring teachers to assign homework? Is homework beneficial to students? Do students learn from completing daily homework? In this article, a review of literature is included offering pros and cons to students doing homework with various counterpoint…

  8. Teaching Triarchically Improves School Achievement.

    ERIC Educational Resources Information Center

    Sternberg, Robert J.; Torff, Bruce; Grigorenko, Elena L.

    1998-01-01

    Two studies involving 213 third graders and 141 eighth graders tested the triarchic structure of human intelligence as applied to the classroom by emphasizing traditional instruction, critical thinking, and triarchically based instruction (analytical, creative, and practical). Results support the superiority of triarchically-based instruction.…

  9. Improving Achievement Via Essay Exams.

    ERIC Educational Resources Information Center

    Milton, Ohmer

    1979-01-01

    The benefits of using essay tests rather than objective tests in professional education programs are discussed. Essay tests offer practice in writing, creativity and formal communications. Guidelines for using and scoring a sample essay test in biology are presented. (BH)

  10. Effectiveness of Music Education for the Improvement of Reading Skills and Academic Achievement in Young Poor Readers: A Pragmatic Cluster-Randomized, Controlled Clinical Trial

    PubMed Central

    Cogo-Moreira, Hugo; de Ávila, Clara Regina Brandão; Ploubidis, George B.; Mari, Jair de Jesus

    2013-01-01

    Introduction Difficulties in word-level reading skills are prevalent in Brazilian schools and may deter children from gaining the knowledge obtained through reading and academic achievement. Music education has emerged as a potential method to improve reading skills because due to a common neurobiological substratum. Objective To evaluate the effectiveness of music education for the improvement of reading skills and academic achievement among children (eight to 10 years of age) with reading difficulties. Method 235 children with reading difficulties in 10 schools participated in a five-month, randomized clinical trial in cluster (RCT) in an impoverished zone within the city of São Paulo to test the effects of music education intervention while assessing reading skills and academic achievement during the school year. Five schools were chosen randomly to incorporate music classes (n = 114), and five served as controls (n = 121). Two different methods of analysis were used to evaluate the effectiveness of the intervention: The standard method was intention-to-treat (ITT), and the other was the Complier Average Causal Effect (CACE) estimation method, which took compliance status into account. Results The ITT analyses were not very promising; only one marginal effect existed for the rate of correct real words read per minute. Indeed, considering ITT, improvements were observed in the secondary outcomes (slope of Portuguese = 0.21 [p<0.001] and slope of math = 0.25 [p<0.001]). As for CACE estimation (i.e., complier children versus non-complier children), more promising effects were observed in terms of the rate of correct words read per minute [β = 13.98, p<0.001] and phonological awareness [β = 19.72, p<0.001] as well as secondary outcomes (academic achievement in Portuguese [β = 0.77, p<0.0001] and math [β = 0.49, p<0.001] throughout the school year). Conclusion The results may be seen as promising, but they are not, in themselves

  11. Closing the social-class achievement gap: a difference-education intervention improves first-generation students' academic performance and all students' college transition.

    PubMed

    Stephens, Nicole M; Hamedani, MarYam G; Destin, Mesmin

    2014-04-01

    College students who do not have parents with 4-year degrees (first-generation students) earn lower grades and encounter more obstacles to success than do students who have at least one parent with a 4-year degree (continuing-generation students). In the study reported here, we tested a novel intervention designed to reduce this social-class achievement gap with a randomized controlled trial (N = 168). Using senior college students' real-life stories, we conducted a difference-education intervention with incoming students about how their diverse backgrounds can shape what they experience in college. Compared with a standard intervention that provided similar stories of college adjustment without highlighting students' different backgrounds, the difference-education intervention eliminated the social-class achievement gap by increasing first-generation students' tendency to seek out college resources (e.g., meeting with professors) and, in turn, improving their end-of-year grade point averages. The difference-education intervention also improved the college transition for all students on numerous psychosocial outcomes (e.g., mental health and engagement). PMID:24553359

  12. Dramatic performance gains of a novel circular vanadium flow battery

    NASA Astrophysics Data System (ADS)

    Zheng, Qiong; Xing, Feng; Li, Xianfeng; Liu, Tao; Lai, Qinzhi; Ning, Guiling; Zhang, Huamin

    2015-03-01

    Vanadium flow battery (VFB) holds great promise for use in large scale energy storage applications. However, one major issue that limits the battery performance is the energy storage capacity loss due to insufficient use of electrolyte. The battery structure design is flexible and acceptable to solve the issue. Based on the mass transport limitation of the conventional rectangular vanadium flow battery (RFB), a novel circular vanadium flow battery (CFB) was firstly proposed in the research. Without increasing pump consumption, the new structure of CFB is effective to achieve mass transport enhancement and concentration polarization reduction. The charge-discharge test confirmed the performance advantage of CFB, presenting a significant increment of 10.52% at 40 mA cm-2 and 30.46% at 160 mA cm-2 in the utilization of electrolyte and improved energy storage capacity by 12.56% at 40 mA cm-2 and a 2.55 times of that for RFB at 160 mA cm-2. The performance advantage of CFB becomes exceptionally evident at high current densities.

  13. Postmastectomy Radiation Improves the Outcome of Patients With Locally Advanced Breast Cancer Who Achieve a Pathologic Complete Response to Neoadjuvant Chemotherapy

    SciTech Connect

    McGuire, Sean E.; Gonzalez-Angulo, Ana M.; Huang, Eugene H.; Tucker, Susan L.; Kau, S.-W.C.; Yu, T.-K.; Strom, Eric A.; Oh, Julia L.; Woodward, Wendy A.; Tereffe, Welela; Hunt, Kelly K.; Kuerer, Henry M.; Sahin, Aysegul A.; Hortobagyi, Gabriel N.; Buchholz, Thomas A. . E-mail: tbuchhol@mdanderson.org

    2007-07-15

    Purpose: The aim of this study was to investigate the role of postmastectomy radiation therapy in women with breast cancer who achieved a pathologic complete response (pCR) to neoadjuvant chemotherapy. Methods and Materials: We retrospectively identified 226 patients treated at our institution who achieved a pCR at surgery after receiving neoadjuvant chemotherapy. Of these, the 106 patients without inflammatory breast cancer who were treated with mastectomy were analyzed. The patients' clinical stages at diagnosis were I in 2%, II in 31%, IIIA in 30%, IIIB in 25%, and IIIC in 11% (American Joint Committee on Cancer 2003 system). Of the patients, 92% received anthracycline-based chemotherapy, and 38% also received a taxane. A total of 72 patients received postmastectomy radiation therapy, and 34 did not. The actuarial rates of local-regional recurrence (LRR) and survival of the two groups were compared using the log-rank test. Results: The median follow-up of surviving patients was 62 months. Use of radiation therapy did not affect the 10-year rates of LRR for patients with Stage I or II disease (the 10-year LRR rates were 0% for both groups). However, the 10-year LRR rate for patients with Stage III disease was significantly improved with radiation therapy (7.3% {+-} 3.5% with vs. 33.3% {+-} 15.7% without; p 0.040). Within this cohort, use of radiation therapy was also associated with improved disease-specific and overall survival. Conclusion: Postmastectomy radiation therapy provides a significant clinical benefit for breast cancer patients who present with clinical Stage III disease and achieve a pCR after neoadjuvant chemothearpy.

  14. Enhanced loading regimen of teicoplanin is necessary to achieve therapeutic pharmacokinetics levels for the improvement of clinical outcomes in patients with renal dysfunction.

    PubMed

    Ueda, T; Takesue, Y; Nakajima, K; Ichiki, K; Doita, A; Wada, Y; Tsuchida, T; Takahashi, Y; Ishihara, M; Ikeuchi, H; Uchino, M; Kimura, T

    2016-09-01

    We evaluated the clinical efficacy and safety of teicoplanin according to the pharmacokinetics (PK) therapeutic level achieved in patients with renal dysfunction. Target trough concentration (Cmin) was ≥15-30 μg/ml which has been recommended in patients with normal renal function. Adult patients (estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)) who were treated by teicoplanin were included in the study. We adopted two types of regimen for the initial 3 days: the conventional regimen, and the enhanced loading regimen (10 mg/kg twice daily on the 1st day, followed by 6.7-10 mg/kg once daily for the 2nd and 3rd days]. Two hundred and eighty-eight patients were evaluated for safety, and 106 patients with methicillin-resistant Staphylococcus aureus (MRSA) infections were evaluated for clinical efficacy. A significantly higher success rate was obtained in patients who achieved the target initial Cmin compared with those that did not (75.0 % vs 50.0 %, p = 0.008). In a multivariate analysis, initial Cmin ≥15 μg/ml was an independent factor for clinical success (adjusted odds ratio: 4.20, 95 % confidence interval: 1.34-13.15). In patients with 15-30 μg/ml of maximal Cmin during therapy, nephrotoxicity occurred in 13.1 %, and hepatotoxicity in 2.6 %, and these incidences were not significantly higher compared with those patients with <15 μg/ml. In conclusion, achievement of Cmin of 15-30 μg/ml without delay was necessary to improve clinical outcomes for the treatment by teicoplanin in patients with renal dysfunction. Further investigation is required regarding the optimal loading regimen to achieve the therapeutic levels in those patients. PMID:27278654

  15. Using optimal combination of teaching-learning methods (open book assignment and group tutorials) as revision exercises to improve learning outcome in low achievers in biochemistry.

    PubMed

    Rajappa, Medha; Bobby, Zachariah; Nandeesha, H; Suryapriya, R; Ragul, Anithasri; Yuvaraj, B; Revathy, G; Priyadarssini, M

    2016-07-01

    Graduate medical students of India are taught Biochemistry by didactic lectures and they hardly get any opportunity to clarify their doubts and reinforce the concepts which they learn in these lectures. We used a combination of teaching-learning (T-L) methods (open book assignment followed by group tutorials) to study their efficacy in improving the learning outcome. About 143 graduate medical students were classified into low (<50%: group 1, n = 23), medium (50-75%: group 2, n = 74), and high (>75%: group 3, n = 46) achievers, based on their internal assessment marks. After the regular teaching module on the topics "Vitamins and Enzymology", all the students attempted an open book assignment without peer consultation. Then all the students participated in group tutorials. The effects on the groups were evaluated by pre and posttests at the end of each phase, with the same set of MCQs. Gain from group tutorials and overall gain was significantly higher in the low achievers, compared to other groups. High and medium achievers obtained more gain from open book assignment, than group tutorials. The overall gain was significantly higher than the gain obtained from open book assignment or group tutorials, in all three groups. All the three groups retained the gain even after 1 week of the exercise. Hence, optimal use of novel T-L methods (open book assignment followed by group tutorials) as revision exercises help in strengthening concepts in Biochemistry in this oft neglected group of low achievers in graduate medical education. © 2016 by The International Union of Biochemistry and Molecular Biology, 44(4):321-325, 2016. PMID:26891594

  16. Exploratory Analyses of the Long-Term Effects of Improving Behavior, Attendance, and Educational Achievement in Grades 1-6 and 8-12. ACT Research Report Series, 2012 (3)

    ERIC Educational Resources Information Center

    Sawyer, Richard; Gibson, Neal

    2012-01-01

    We studied relationships among background characteristics, behavioral infractions, punishments, attendance, and educational achievement, using longitudinal data of students in grades 1-6 and 8-12. We estimated how much hypothesized early improvements in educational achievement or sustained improvements in behavior and attendance might ultimately…

  17. Multiple nontuberculous scrofulodermas showing dramatic response to clarithromycin.

    PubMed

    Parimalam, Kumar; Senthil, G; Vinnarasan, M; Arumugakani, V; Amutha, B M; Lalitha, S; Swarna, S

    2015-01-01

    Atypical mycobacteria are distinct from the Mycobacterium tuberculosis. Mycobacterium chelonae, a non-pigment producing rapid grower, can be found in many cutaneous sites; infection occurs most commonly after skin trauma from surgery, injections, or minor injuries. In immune competent patients, the infection is more frequently localized as a cellulitis or a nodule, whereas, in the immunocompromised patient, dissemination (more than five lesions) can occur. Because the organism is resistant to antituberculous therapy, abscess can develop and follow a chronic, indolent course. We report a case of multiple scrofuloderma due to nontuberculous infection caused by M. chelonae showing dramatic response to clarithromycin. PMID:25657914

  18. Intra-arrest Hypothermia: Both Cold Liquid Ventilation with Perfluorocarbons and Cold Intravenous Saline Rapidly Achieve Hypothermia, but Only Cold Liquid Ventilation Improves Resumption of Spontaneous Circulation

    PubMed Central

    Riter, Henry G.; Brooks, Leonard A.; Pretorius, Andrew M.; Ackermann, Laynez W.; Kerber, Richard E.

    2009-01-01

    Background Rapid intra-arrest induction of hypothermia using total liquid ventilation (TLV) with cold perfluorocarbons improves resuscitation outcome from ventricular fibrillation (VF). Cold saline intravenous infusion during cardiopulmonary resuscitation (CPR) is a simpler method of inducing hypothermia. We compared these 2 methods of rapid hypothermia induction for cardiac resuscitation. Methods Three groups of swine were studied: cold preoxygenated TLV (TLV, n=8), cold intravenous saline infusion (S, n=8), and control (C, n=8). VF was electrically induced. Beginning at 8 minutes of VF, TLV and S animals received 3 minutes of cold TLV or rapid cold saline infusion. After 11 minutes of VF, all groups received standard air ventilation and closed chest massage. Defibrillation was attempted after 3 minutes of CPR (14 minutes of VF). The end point was resumption of spontaneous circulation (ROSC). Results Pulmonary arterial (PA) temperature decreased after 1 minute of CPR from 37.2°C to 32.2°C in S and from 37.1°C to 34.8°C in TLV (S or TLV vs. C p<0.0001). Coronary perfusion pressure (CPP) was higher in TLV than S animals during the initial 3 minutes of CPR. Arterial pO2 was higher in the preoxygenated TLV animals. ROSC was achieved in 7 of 8 TLV, 2 of 8 S, and 1 of 8 C (TLV vs. C, p=0.03). Conclusions Moderate hypothermia was achieved rapidly during VF and CPR using both cold saline infusion and cold TLV, but ROSC was higher than control only in cold TLV animals, probably due to better CPP and pO2. The method by which hypothermia is achieved influences ROSC. PMID:19249149

  19. Dramatic rigidification of a peptide-decorated lamellar phase

    NASA Astrophysics Data System (ADS)

    Tsapis, N.; Urbach, W.; Ober, R.

    2001-04-01

    We have performed small-angle x-ray scattering on a lamellar (Lα) phase made of a nonionic surfactant (C12E4), decane, and water, after the insertion of a triblock peptide. The hydrophilic part of the peptide is rigid and organized in an α helix in the presence of membranes. Surface tension measurements and spectrofluorometry show that the peptide lies on the membrane surface. The Caillé parameter η and the smectic compressibility modulus B¯ decrease with peptide concentration, whereas the membrane bending rigidity κ increases threefold for mole ratio of peptide to surfactant as low as 5.2×10-4. The published models for rigid inclusions in membranes cannot account for this dramatic rigidification. However, experimental results are well fitted by a Heuristic renormalization of the membrane thickness.

  20. The Cardiovascular Intervention Improvement Telemedicine Study (CITIES): Rationale for a Tailored Behavioral and Educational Pharmacist-Administered Intervention for Achieving Cardiovascular Disease Risk Reduction

    PubMed Central

    Zullig, Leah L.; Melnyk, S. Dee; Stechuchak, Karen M.; McCant, Felicia; Danus, Susanne; Oddone, Eugene; Bastian, Lori; Olsen, Maren; Edelman, David; Rakley, Susan; Morey, Miriam

    2014-01-01

    Abstract Background: Hypertension, hyperlipidemia, and diabetes are significant, but often preventable, contributors to cardiovascular disease (CVD) risk. Medication and behavioral nonadherence are significant barriers to successful hypertension, hyperlidemia, and diabetes management. Our objective was to describe the theoretical framework underlying a tailored behavioral and educational pharmacist-administered intervention for achieving CVD risk reduction. Materials and Methods: Adults with poorly controlled hypertension and/or hyperlipidemia were enrolled from three outpatient primary care clinics associated with the Durham Veterans Affairs Medical Center (Durham, NC). Participants were randomly assigned to receive a pharmacist-administered, tailored, 1-year telephone-based intervention or usual care. The goal of the study was to reduce the risk for CVD through a theory-driven intervention to increase medication adherence and improve health behaviors. Results: Enrollment began in November 2011 and is ongoing. The target sample size is 500 patients. Conclusions: The Cardiovascular Intervention Improvement Telemedicine Study (CITIES) intervention has been designed with a strong theoretical underpinning. The theoretical foundation and intervention are designed to encourage patients with multiple comorbidities and poorly controlled CVD risk factors to engage in home-based monitoring and tailored telephone-based interventions. Evidence suggests that clinical pharmacist-administered telephone-based interventions may be efficiently integrated into primary care for patients with poorly controlled CVD risk factors. PMID:24303930

  1. A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene.

    PubMed

    Boehm, Fritz; Edge, Ruth; Truscott, Terence George; Witt, Christian

    2016-04-01

    Reducing radiation damage is important and dietary antioxidants that can protect cells from such damage are of value. Dietary lycopene, a carotenoid found in tomatoes, protects human lymphoid cell membranes from damage by γ-radiation. We report that such protective effects are remarkably reduced as the oxygen concentration increases - near zero at 100% oxygen from fivefold protection at 20% oxygen and, dramatically, from 50-fold protection at 0% oxygen. Such huge differences imply that under higher oxygen concentrations lycopene could lead to improved cancer therapy using γ-radiation. The cells are not efficiently protected from the superoxide radical by lycopene. Noncellular studies suggest molecular mechanisms for the oxygen effect. PMID:26991327

  2. Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration.

    PubMed

    Imamura, Teruhiko; Kinugawa, Koichiro

    2015-01-01

    "Shoshin beriberi", which is a fulminant form of cardiovascular beriberi accompanied by hemodynamic deterioration with high cardiac output and decreased systemic blood pressure, caused by thiamine deficiency due to alcoholic abuse or malnutrition, is often difficult to address because of its rarity and non-specific symptoms. We here present a patient with a history of alcoholic abuse who had suffered hemodynamic deterioration with extremely low cardiac output refractory to extracorporeal membrane oxygenation and intravenous catecholamine support, which was improved dramatically by bolus intravenous thiamine administration. Such a type with low cardiac output would be the most severe form of Shoshin beriberi, and cannot be rescued without diagnostic administration of thiamine. PMID:26346515

  3. The Relationship between Dramatic Play and Self-Concept in Middle Class Kindergarten Children.

    ERIC Educational Resources Information Center

    Gootman, Marilyn Eisenstadt

    This study attempted to determine the relationships between the dramatic play of children aged three to seven and their self-concept; between dramatic play and two components of self-concept--self-esteem and identification with friends; between dramatic play ability and self-concept; and between dramatic play and the teacher's attitude toward…

  4. Aiming at Achievement.

    ERIC Educational Resources Information Center

    Martinez, Paul

    The Raising Quality and Achievement Program is a 3-year initiative to support further education (FE) colleges in the United Kingdom in their drive to improve students' achievement and the quality of provision. The program offers the following: (1) quality information and advice; (2) onsite support for individual colleges; (3) help with…

  5. Anions dramatically enhance proton transfer through aqueous interfaces

    PubMed Central

    Mishra, Himanshu; Enami, Shinichi; Nielsen, Robert J.; Hoffmann, Michael R.; Goddard, William A.; Colussi, Agustín J.

    2012-01-01

    Proton transfer (PT) through and across aqueous interfaces is a fundamental process in chemistry and biology. Notwithstanding its importance, it is not generally realized that interfacial PT is quite different from conventional PT in bulk water. Here we show that, in contrast with the behavior of strong nitric acid in aqueous solution, gas-phase HNO3 does not dissociate upon collision with the surface of water unless a few ions (> 1 per 106 H2O) are present. By applying online electrospray ionization mass spectrometry to monitor in situ the surface of aqueous jets exposed to HNO3(g) beams we found that production increases dramatically on > 30-μM inert electrolyte solutions. We also performed quantum mechanical calculations confirming that the sizable barrier hindering HNO3 dissociation on the surface of small water clusters is drastically lowered in the presence of anions. Anions electrostatically assist in drawing the proton away from lingering outside the cluster, whose incorporation is hampered by the energetic cost of opening a cavity therein. Present results provide both direct experimental evidence and mechanistic insights on the counterintuitive slowness of PT at water-hydrophobe boundaries and its remarkable sensitivity to electrostatic effects. PMID:22689964

  6. Unusual Dramatic Surface Restructuring of Silicon Substrate during Epitaxy

    NASA Astrophysics Data System (ADS)

    Gupta, Tanya; Steingart, Daniel; Hannon, James; Princeton University Collaboration; IBM Collaboration

    2015-03-01

    Interfacial strain is unavoidable in heteroepitaxial growth and can have a profound impact on the morphology and properties of thin films. In fact, ``engineering'' thin-film strain is a critical component in many advanced technologies. For example, straining the silicon in advanced CMOS devices can increase the device speed by as much as 90 percent.order to control interfacial strain, its effects on growth must be understood. The common picture is that the growth substrate is essentially passive: its role is to provide the lattice mismatch that the growing film must respond to. As the film grows thicker, the stress in the film evolves, which can lead to morphological changes in the film, e.g. dislocations, or a change in growth mode from 2D, planar growth to 3D, quantum dot growth., in both of these examples, the action is in the growing film. In this work we describe a growth system that behaves in a completely unexpected manner that does not fit into this conventional picture. Interfacial strain that accompanies the growth of SiC nanoparticles is relieved by a dramatic restructuring of the *substrate* rather than the nanoparticles. The growth of nanoparticles induces a massive change in the substrate. In situ measurements of the Si mound formation was done with the use of LEEM. Using a simple, illustrative model with parameters taken from the literature, we show that the shapes and heights of the mounds are consistent with a strain-driven formation mechanism.

  7. Dramatic long-term X-ray variability in AGNs

    NASA Astrophysics Data System (ADS)

    Moran, Edward C.

    2016-04-01

    Dramatic X-ray and optical variability on ˜ 10 year timescales has been discovered recently in a handful of quasars, which may provide important new insight into the issue of how luminous AGNs are fueled. We have assembled a new sample of extremely variable X-ray sources from archival Einstein and ROSAT data that could increase substantially the number of such objects known. The sources in our sample varied in X-ray flux by at least a factor of 7-8 over a 10-year span, and most exhibited significantly larger variability amplitudes (10 to over 100). We present the details of how our sample was assembled and preliminary results regarding the identifications, properties, and X-ray histories of the objects. Although a heterogeneous population is expected, some sources in the sample are associated with broad-line AGNs, including a radio-quiet quasar at z = 1.3 that decreased in X-ray luminosity by a factor of 40.

  8. New therapies for hereditary angioedema: disease outlook changes dramatically.

    PubMed

    Frank, Michael M; Jiang, Haixiang

    2008-01-01

    Hereditary angioedema (HAE) is an autosomal dominant disease associated with episodic attacks of nonpitting edema that may affect any external or mucosal body surface. Attacks most often affect the extremities, causing local swelling, the GI tract, leading to severe abdominal pain, and the mouth and throat, at times causing asphyxiation. Most patients with HAE have low levels of the plasma serine protease inhibitor C1 inhibitor. The edema in these patients is caused by unregulated generation of bradykinin. Effective chronic therapy of patients with impeded androgens or plasmin inhibitors has been available for decades, but in the United States, we do not have therapy for acute attacks. Five companies have completed or are in the process of conducting phase 3 clinical trials, double-blind, placebo-controlled studies of products designed to terminate acute attacks or to be used in prophylaxis. Two companies, Lev Pharmaceuticals and CSL Behring, have preparations of C1 inhibitor purified from plasma that have been used in Europe for decades (trade names Cinryze and Berinert P, respectively). One company, Pharming, has developed a recombinant C1 inhibitor preparation. One company, Dyax, is testing a kallikrein inhibitor (ecallantide), and one company, Jerini, is completing testing of a bradykinin type 2 receptor antagonist (Icatibant). Although little has been published thus far, all of these products may prove effective. It is likely that HAE treatment will change dramatically within the next few years. PMID:18206518

  9. A Dramatic Change in the Polarization of V Hya

    NASA Astrophysics Data System (ADS)

    Johnson, J. J.

    1993-12-01

    The unusual carbon star, V Hydrae, is a semiregular variable with a period of 530 days superimposed on a longer, large amplitude period of 6500 days. It has been observed to have bipolar CO outflow (Kahane et al., 1988), and is believed to be an early precursor of a bipolar planetary nebula (Tsuji et al., 1988). In an earlier program (Johnson and Jones, 1991), we observed V Hya with a broad-band polarimeter. We found that it was intrinsically polarized with P on the order of 0.7% at V. We re-observed V Hya at the University of Wisconsin's Pine Bluff Observatory using a spectropolarimeter, and found that the polarization has increased dramatically to 10% at V, with a near 90 degree rotation in position angle from the earlier observation. Near the epoch when we observed V Hya for the second time, it was reported by T. L. Evans that V Hya was experiencing a decline in visible light. The infrared colors have also become redder, suggesting a possible dust ejection episode. V Hya is expected to reach a deep minimum sometime in 1994. We combine our polarimetric observations with our infrared and optical photometry and optical spectroscopy to propose a possible explanation for the polarimetric variations.

  10. Taming Self-Organization Dynamics to Dramatically Control Porous Architectures.

    PubMed

    Daly, Ronan; Sader, John E; Boland, John J

    2016-03-22

    We demonstrate templating of functional materials with unexpected and intricate micro- and nanostructures by controlling the condensation, packing, and evaporation of water droplets on a polymer solution. Spontaneous evaporation of a polymer solution induces cooling of the liquid surface and water microdroplet condensation from the ambient vapor. These droplets pack together and act as a template to imprint an entangled polymer film. This breath figure (BF) phenomenon is an example of self-organization that involves the long-range ordering of droplets. Equilibrium-based analysis provides many insights into contact angles and drop stability of individual drops, but the BF phenomenon remains poorly understood thus far, preventing translation to real applications. Here we investigate the dynamics of this phenomenon to separate out the competing influences and then introduce a modulation scheme to ultimately manipulate the water vapor-liquid equilibrium independently from the solvent evaporation. This approach to BF control provides insights into the mechanism, a rationale for microstructure design, and evidence for the benefits of dynamical control of self-organization systems. We finally present dramatically different porous architectures from this approach reminiscent of microscale Petri dishes, conical flasks, and test tubes. PMID:26828573

  11. Anions dramatically enhance proton transfer through aqueous interfaces.

    PubMed

    Mishra, Himanshu; Enami, Shinichi; Nielsen, Robert J; Hoffmann, Michael R; Goddard, William A; Colussi, Agustín J

    2012-06-26

    Proton transfer (PT) through and across aqueous interfaces is a fundamental process in chemistry and biology. Notwithstanding its importance, it is not generally realized that interfacial PT is quite different from conventional PT in bulk water. Here we show that, in contrast with the behavior of strong nitric acid in aqueous solution, gas-phase HNO(3) does not dissociate upon collision with the surface of water unless a few ions (> 1 per 10(6) H(2)O) are present. By applying online electrospray ionization mass spectrometry to monitor in situ the surface of aqueous jets exposed to HNO(3(g)) beams we found that NO(3)(-) production increases dramatically on > 30-μM inert electrolyte solutions. We also performed quantum mechanical calculations confirming that the sizable barrier hindering HNO(3) dissociation on the surface of small water clusters is drastically lowered in the presence of anions. Anions electrostatically assist in drawing the proton away from NO(3)(-) lingering outside the cluster, whose incorporation is hampered by the energetic cost of opening a cavity therein. Present results provide both direct experimental evidence and mechanistic insights on the counterintuitive slowness of PT at water-hydrophobe boundaries and its remarkable sensitivity to electrostatic effects. PMID:22689964

  12. Impacts on Coralligenous Outcrop Biodiversity of a Dramatic Coastal Storm

    PubMed Central

    Teixidó, Núria; Casas, Edgar; Cebrián, Emma; Linares, Cristina; Garrabou, Joaquim

    2013-01-01

    Extreme events are rare, stochastic perturbations that can cause abrupt and dramatic ecological change within a short period of time relative to the lifespan of organisms. Studies over time provide exceptional opportunities to detect the effects of extreme climatic events and to measure their impacts by quantifying rates of change at population and community levels. In this study, we show how an extreme storm event affected the dynamics of benthic coralligenous outcrops in the NW Mediterranean Sea using data acquired before (2006–2008) and after the impact (2009–2010) at four different sites. Storms of comparable severity have been documented to occur occasionally within periods of 50 years in the Mediterranean Sea. We assessed the effects derived from the storm comparing changes in benthic community composition at sites exposed to and sheltered from this extreme event. The sites analyzed showed different damage from severe to negligible. The most exposed and impacted site experienced a major shift immediately after the storm, represented by changes in the species richness and beta diversity of benthic species. This site also showed higher compositional variability immediately after the storm and over the following year. The loss of cover of benthic species resulted between 22% and 58%. The damage across these species (e.g. calcareous algae, sponges, anthozoans, bryozoans, tunicates) was uneven, and those with fragile forms were the most impacted, showing cover losses up to 50 to 100%. Interestingly, small patches survived after the storm and began to grow slightly during the following year. In contrast, sheltered sites showed no significant changes in all the studied parameters, indicating no variations due to the storm. This study provides new insights into the responses to large and rare extreme events of Mediterranean communities with low dynamics and long-lived species, which are among the most threatened by the effects of global change. PMID:23326496

  13. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice

    PubMed Central

    Libersa, Christian C; Brique, Serge A; Motte, Kokou B; Caron, Jacques F; Guédon-Moreau, Laurence M; Humbert, Luc; Vincent, A; Devos, Patrick; Lhermitte, Michel A

    2000-01-01

    Aims Grapefruit juice increases blood concentrations of many drugs metabolized by CYP3A. Amiodarone is metabolized by CYP3A to N-desethylamiodarone (N-DEA). The aim of this study was to determine amiodarone kinetics when administrated with and without grapefruit juice. Methods Eleven healthy adult volunteers took part in a single sequence, repeated-measures design study. Each subject, who had been evaluated 6 months previously for amiodarone pharmacokinetics, was given a single oral dose of amiodarone (17 mg kg−1) with three glasses of 300 ml of grapefruit juice on the same day. Results Grapefruit juice completely inhibited the production of N-DEA, the major metabolite of amiodarone, in all subjects and increased the area-under-the-curve (AUC) and maximum concentration of amiodarone (Cmax) by 50% and 84%, respectively, as compared with the control period during which water had been administrated instead of grapefruit juice (AUC: 35.9 ± 14.3 vs 23.9 ± 11.2 µg ml−1 h, P < 0.005 and Cmax: 3.45 ± 1.7 vs 1.87 ± 0.6 µg ml−1, P < 0. 02, respectively) (means ± s.d.). This inhibition of N-DEA production led to a decrease in the alterations caused by amiodarone on PR and QTc intervals. Conclusions Grapefruit juice dramatically alters the metabolism of amiodarone with complete inhibition of N-DEA production. These results are in agreement with in vitro data pointing to the involvement of CYP3 A in the metabolism of amiodarone and suggests that this interaction should be taken into account when prescribing this antiarrhythmic drug. PMID:10759694

  14. Dorsal Raphe Neuroinflammation Promotes Dramatic Behavioral Stress Dysregulation

    PubMed Central

    Howerton, Alexis R.; Roland, Alison V.

    2014-01-01

    Impulsivity, risk-taking behavior, and elevated stress responsivity are prominent symptoms of mania, a behavioral state common to schizophrenia and bipolar disorder. Though inflammatory processes activated within the brain are involved in the pathophysiology of both disorders, the specific mechanisms by which neuroinflammation drives manic behavior are not well understood. Serotonin cell bodies originating within the dorsal raphe (DR) play a major role in the regulation of behavioral features characteristic of mania. Therefore, we hypothesized that the link between neuroinflammation and manic behavior may be mediated by actions on serotonergic neurocircuitry. To examine this, we induced local neuroinflammation in the DR by viral delivery of Cre recombinase into interleukin (IL)-1βXAT transgenic male and female mice, resulting in overexpressing of the proinflammatory cytokine, IL-1β. For assertion of brain-region specificity of these outcomes, the prefrontal cortex (PFC), as a downstream target of DR serotonergic projections, was also infused. Inflammation within the DR, but not the PFC, resulted in a profound display of manic-like behavior, characterized by increased stress-induced locomotion and responsivity, and reduced risk-aversion/fearfulness. Microarray analysis of the DR revealed a dramatic increase in immune-related genes, and dysregulation of genes important in GABAergic, glutamatergic, and serotonergic neurotransmission. Behavioral and physiological changes were driven by a loss of serotonergic neurons and reduced output as measured by high-performance liquid chromatography, demonstrating inflammation-induced serotonergic hypofunction. Behavioral changes were rescued by acute selective serotonin reuptake inhibitor treatment, supporting the hypothesis that serotonin dysregulation stemming from neuroinflammation in the DR underlies manic-like behaviors. PMID:24849347

  15. Liven up Your Student Dramatics with Commedia dell' Arte.

    ERIC Educational Resources Information Center

    Potter, Jonathan

    1980-01-01

    Suggests using the ancient Commedia dell' Arte technique of establishing characters and a plot and then allowing the actors to create their own play. Indicates that this improves student performances even in more traditional plays. (TJ)

  16. Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules.

    PubMed

    Stavenga, Doekele G; Leertouwer, Hein L; Marshall, N Justin; Osorio, Daniel

    2011-07-22

    The breast-plate plumage of male Lawes' parotia (Parotia lawesii) produces dramatic colour changes when this bird of paradise displays on its forest-floor lek. We show that this effect is achieved not solely by the iridescence--that is an angular-dependent spectral shift of the reflected light--which is inherent in structural coloration, but is based on a unique anatomical modification of the breast-feather barbule. The barbules have a segmental structure, and in common with many other iridescent feathers, they contain stacked melanin rodlets surrounded by a keratin film. The unique property of the parotia barbules is their boomerang-like cross section. This allows each barbule to work as three coloured mirrors: a yellow-orange reflector in the plane of the feather, and two symmetrically positioned bluish reflectors at respective angles of about 30°. Movement during the parotia's courtship displays thereby achieves much larger and more abrupt colour changes than is possible with ordinary iridescent plumage. To our knowledge, this is the first example of multiple thin film or multi-layer reflectors incorporated in a single structure (engineered or biological). It nicely illustrates how subtle modification of the basic feather structure can achieve novel visual effects. The fact that the parotia's breast feathers seem to be specifically adapted to give much stronger colour changes than normal structural coloration implies that colour change is important in their courtship display. PMID:21159676

  17. Dramatic decrease of carnitine esters after interruption of exogenous carnitine supply in hemodialysis patients.

    PubMed

    Bene, Judit; Csiky, Botond; Wittmann, Istvan; Sulyok, Endre; Melegh, Bela

    2012-01-01

    L-carnitine supplementation is extensively used in patients on maintenance hemodialysis (HD) to improve dialysis-related clinical symptoms. In a series of studies, we investigated the dynamics of carnitine pool in carnitine-supplemented HD patients; here we report dramatic decrease with special changes of the ester profile due to interruption of the exogenous intake after the last HD session. Serum samples were collected from 18 L-carnitine-repleted end-stage renal disease (ESRD) patients before the L-carnitine supplementation, after completion of a carnitine supplementation period treatment (12 weeks, 1 g/IV/HD), right before the HD session, and 44 h after the dialysis. Levels of free carnitine (FC) and the individual esters were determined using electrospray MS/MS technique. Normally, L-carnitine supplementation causes significant elevation of all carnitine compounds to supraphysiological levels, which reaches a standard steady-state-like profile. In this study we found a dramatic decrease in the level of FC, and in short- and medium-chain acylcarnitines (ACs) 44 h after the last dialysis. At the end of this interdialytic period, FC levels increased to only 65% of the predialysis level, whereas the amounts of C2 and C3 esters recovered to only 50%. The level of C6 was 65% of the predialysis level, whereas the amount of C8 chain length ACs returned to 72% of the predialysis level. No significant change was seen in AC concentrations above C10 chain length. Omission of one single dosage of supplemental carnitine in long-term administration schemes results in dramatic decrease and reprofiling of carnitine esters even after the usual 44 h of interdialytic period. PMID:22417076

  18. Accuracy of Numerical Simulations of Tip Clearance Flow in Transonic Compressor Rotors Improved Dramatically

    NASA Technical Reports Server (NTRS)

    VanZante, Dale E.; Strazisar, Anthony J.; Wood, Jerry R.; Hathaway, Michael D.; Okiishi, Theodore H.

    2000-01-01

    The tip clearance flows of transonic compressor rotors have a significant impact on rotor and stage performance. Although numerical simulations of these flows are quite sophisticated, they are seldom verified through rigorous comparisons of numerical and measured data because, in high-speed machines, measurements acquired in sufficient detail to be useful are rare. Researchers at the NASA Glenn Research Center at Lewis Field compared measured tip clearance flow details (e.g., trajectory and radial extent) of the NASA Rotor 35 with results obtained from a numerical simulation. Previous investigations had focused on capturing the detailed development of the jetlike flow leaking through the clearance gap between the rotating blade tip and the stationary compressor shroud. However, we discovered that the simulation accuracy depends primarily on capturing the detailed development of a wall-bounded shear layer formed by the relative motion between the leakage jet and the shroud.

  19. President Obama and Education: The Possibility for Dramatic Improvements in Teaching and Learning

    ERIC Educational Resources Information Center

    Darling-Hammond, Linda

    2009-01-01

    From the unique perspective gained heading Obama's education policy transition team, Darling-Hammond describes President Obama's commitment to making the education of every child a collective responsibility and reviews the major tenets of the new administration's plans for education. She reflects on the importance of suggested policy changes,…

  20. Integrated System Dramatically Improves Hydrogen Molar Yield from Biomass via Fermentation (Fact Sheet)

    SciTech Connect

    Not Available

    2010-11-01

    This fact sheet describes NREL's accomplishments in fermentative and electrohydrogenic production of hydrogen from corn stover. Work was performed by NREL's Biosciences Center and Pennsylvania State University.

  1. [Achievement of therapeutic objectives].

    PubMed

    Mantilla, Teresa

    2014-07-01

    Therapeutic objectives for patients with atherogenic dyslipidemia are achieved by improving patient compliance and adherence. Clinical practice guidelines address the importance of treatment compliance for achieving objectives. The combination of a fixed dose of pravastatin and fenofibrate increases the adherence by simplifying the drug regimen and reducing the number of daily doses. The good tolerance, the cost of the combination and the possibility of adjusting the administration to the patient's lifestyle helps achieve the objectives for these patients with high cardiovascular risk. PMID:25043543

  2. World-Wide Effort Produces Dramatic "Movie" of Cosmic Jet

    NASA Astrophysics Data System (ADS)

    2001-05-01

    Astronomers using a world-wide collection of radio telescopes, including the National Science Foundation's Very Long Baseline Array (VLBA) of the National Radio Astronomy Observatory (NRAO), have made a dramatic "movie" of a voracious, superdense neutron star repeatedly spitting out subatomic particles at nearly the speed of light into two narrow jets as it pulls material from a companion star. The movie shows these jets ejecting clouds of hot plasma that are then "zapped" by pulses of energy in the jets as they move away from the neutron star. Frame from Radio-Telescope 'Movie' of Scorpius X-1 "We have directly measured the speed of energy flow in a cosmic jet for the first time," said Ed Fomalont, an astronomer at the NRAO in Charlottesville, Virginia. Fomalont worked with Barry Geldzahler and Charles Bradshaw of George Mason University in Fairfax, Virginia. The astronomers used the VLBA, the NSF's Very Large Array (VLA) and the Green Bank 140-foot telescope, along with radio telescopes from the European VLBI Network, Australia, Japan and South Africa to record the double-star system's eruptions continuously for 56 hours. "This study is going to be extremely valuable in helping us understand a phenomenon that we see throughout the universe," Fomalont said. Cosmic jets of superfast particles are ejected from the cores of numerous galaxies. On a smaller scale, similar jets are ejected from binary-star systems closer to home, in our own Milky Way Galaxy. While the jets from galaxy cores are thought to be powered by supermassive black holes millions of times more massive than the Sun, the closer "microquasars" are powered by much smaller black holes or by neutron stars only a few times more massive than the sun. "Studying one of the closer, smaller examples will help us understand how they all work, including the bigger ones," Geldzahler said. "The jets coming from distant galaxies are harder to study because of their much greater distance and the slowness of their

  3. Unique Tuft Test Facility Dramatically Reduces Brush Seal Development Costs

    NASA Technical Reports Server (NTRS)

    Fellenstein, James A.

    1997-01-01

    Brush seals have been incorporated in the latest turbine engines to reduce leakage and improve efficiency. However, the life of these seals is limited by wear. Studies have shown that optimal sealing characteristics for a brush seal occur before the interference fit between the brush and shaft is excessively worn. Research to develop improved tribopairs (brush and coating) with reduced wear and lower friction has been hindered by the lack of an accurate, low-cost, efficient test methodology. Estimated costs for evaluating a new material combination in an engine company seal test program are on the order of $100,000. To address this need, the NASA Lewis Research Center designed, built, and validated a unique, innovative brush seal tuft tester that slides a single tuft of brush seal wire against a rotating shaft under controlled loads, speeds, and temperatures comparable to those in turbine engines. As an initial screening tool, the brush seal tuft tester can tribologicaly evaluate candidate seal materials for 1/10th the cost of full-scale seal tests. Previous to the development of the brush seal tuft tester facility, most relevant tribological data had been obtained from full-scale seal tests conducted primarily to determine seal leakage characteristics. However, from a tribological point of view, these tests included the confounding effects of varying contact pressures, bristle flaring, high-temperature oxidation, and varying bristle contact angles. These confounding effects are overcome in tuft testing. The interface contact pressures can be either constant or varying depending on the tuft mounting device, and bristle wear can be measured optically with inscribed witness marks. In a recent cooperative program with a U.S. turbine engine manufacturer, five metallic wire candidates were tested against a plasma-sprayed Nichrome-bonded chrome carbide. The wire materials used during this collaboration were either nickel-chrome- or cobaltchrome-based superalloys. These

  4. Restricted Field IMRT Dramatically Enhances IMRT Planning for Mesothelioma

    SciTech Connect

    Allen, Aaron M. Schofield, Deborah; Hacker, Fred; Court, Laurence E.; Czerminska, Maria M.S.

    2007-12-01

    Purpose: To improve the target coverage and normal tissue sparing of intensity-modulated radiotherapy (IMRT) for mesothelioma after extrapleural pneumonectomy. Methods and Materials: Thirteen plans from patients previously treated with IMRT for mesothelioma were replanned using a restricted field technique. This technique was novel in two ways. It limited the entrance beams to 200{sup o} around the target and three to four beams per case had their field apertures restricted down to the level of the heart or liver to further limit the contralateral lung dose. New constraints were added that included a mean lung dose of <9.5 Gy and volume receiving {>=}5 Gy of <55%. Results: In all cases, the planning target volume coverage was excellent, with an average of 97% coverage of the planning target volume by the target dose. No change was seen in the target coverage with the new technique. The heart, kidneys, and esophagus were all kept under tolerance in all cases. The average mean lung dose, volume receiving {>=}20 Gy, and volume receiving {>=}5 Gy with the new technique was 6.6 Gy, 3.0%, and 50.8%, respectively, compared with 13.8 Gy, 15%, and 90% with the previous technique (p < 0.0001 for all three comparisons). The maximal value for any case in the cohort was 8.0 Gy, 7.3%, and 57.5% for the mean lung dose, volume receiving {>=}20 Gy, and volume receiving {>=}5 Gy, respectively. Conclusion: Restricted field IMRT provides an improved method to deliver IMRT to a complex target after extrapleural pneumonectomy. An upcoming Phase I trial will provide validation of these results.

  5. Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.

    PubMed

    Shih, Ying-Yih; Hsiao, Liang-Tsai; Yang, Ching-Fen; Wu, Yu-Chung; Chiou, Tzeon-Jye

    2008-01-01

    Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia. However, the relationship between IMF and malignant thymoma has not been published before. Here, we report a 48-year-old woman who was initially diagnosed of IMF with severe anemia and transfusion dependent. Five years later, malignant thymoma was found when she was examined for chronic cough. After performing extended thymectomy, her anemia dramatically recovered to normal and sustained for 2 years till last follow-up. Her splenomegaly and myelofibrosis were also improved. We hypothesized that her malignant thymoma induced the progression of IMF, especially in anemia. PMID:18224414

  6. Dramatic niche shifts and morphological change in two insular bird species

    PubMed Central

    Alström, Per; Jønsson, Knud A.; Fjeldså, Jon; Ödeen, Anders; Ericson, Per G. P.; Irestedt, Martin

    2015-01-01

    Colonizations of islands are often associated with rapid morphological divergence. We present two previously unrecognized cases of dramatic morphological change and niche shifts in connection with colonization of tropical forest-covered islands. These evolutionary changes have concealed the fact that the passerine birds madanga, Madanga ruficollis, from Buru, Indonesia, and São Tomé shorttail, Amaurocichla bocagii, from São Tomé, Gulf of Guinea, are forest-adapted members of the family Motacillidae (pipits and wagtails). We show that Madanga has diverged mainly in plumage, which may be the result of selection for improved camouflage in its new arboreal niche, while selection pressures for other morphological changes have probably been weak owing to preadaptations for the novel niche. By contrast, we suggest that Amaurocichla's niche change has led to divergence in both structure and plumage. PMID:26064613

  7. Dramatic regression and bleeding of a duodenal GIST during preoperative imatinib therapy: case report and review

    PubMed Central

    2010-01-01

    Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. The majority of GISTs is located in the stomach. Only 3-5% of GISTs are located in the duodenum associated with an increased risk of gastrointestinal bleeding as primary manifestation. With response rates of up to 90%, but complications like bleeding due to tumor necrosis in 3%, imatinib mesylate dramatically altered the pre- and postoperative therapy for GIST patients. Case presentation A 58-year-old female patient presented with acute upper gastrointestinal bleeding 2 weeks after a giant GIST of the duodenum had been diagnosed. Neoadjuvant imatinib therapy had been initiated to achieve a tumor downsizing prior to surgery. During emergency laparotomy a partial duodenopancreatectomy was performed to achieve a complete resection of the mass. Histology revealed a high-malignancy GIST infiltrating the duodenal wall. Adjuvant imatinib therapy was initiated. At follow-up (19 months) the patient is still alive and healthy. Conclusion Giant GISTs of the duodenum are rare and - in contrast to other localizations - harbour a higher risk of serious bleeding as primary manifestation. Tumor necrosis and tumor bleeding are rare but typical adverse effects of imatinib therapy especially during treatment of high-malignancy GIST. In GIST patients with increased risk of tumor bleeding neoadjuvant imatinib therapy should thoroughly be performed during hospitalization. In cases of duodenal GIST primary surgery should be considered as treatment alternative. PMID:20515511

  8. PACS implementation dramatically impacts people and radiology work processes

    NASA Astrophysics Data System (ADS)

    Ouvry, Ann

    1997-05-01

    The technology is not the bottleneck anymore in PACS implementation, it has become clear that the key to the success of PACS is understanding the current process, the end-user requirements, and how these processes will change with the introduction of PACS. We will discuss how implementation of PACS changed the working procedures in the Radiology department of Visby Hospital. Visby Hospital in Gotland, Sweden has approximately 160 beds. The Radiology department performs approximately 33,000 examinations per year and is capable of offering a broad range of diagnostic imaging services including CT and MRI. When a new facility was built in 1994, the decision was made to go for filmless operation and a modern information infrastructure. The new facility went operational by the end of 1994, in August 1995 almost filmless operation was reached. Continuing effort and attention is being paid to further simplify the workflow and working procedures in the Radiology department, and to improve the services offered to referring physicians. Although the project aimed at filmless operation, the main goal was to organize for efficient operation and excellent service, thereby maintaining high quality standards and employee satisfaction.

  9. Dramatic increase in fatigue life in hierarchical graphene composites.

    PubMed

    Yavari, F; Rafiee, M A; Rafiee, J; Yu, Z-Z; Koratkar, N

    2010-10-01

    We report the synthesis and fatigue characterization of fiberglass/epoxy composites with various weight fractions of graphene platelets infiltrated into the epoxy resin as well as directly spray-coated on to the glass microfibers. Remarkably only ∼0.2% (with respect to the epoxy resin weight and ∼0.02% with respect to the entire laminate weight) of graphene additives enhanced the fatigue life of the composite in the flexural bending mode by up to 1200-fold. By contrast, under uniaxial tensile fatigue conditions, the graphene fillers resulted in ∼3-5-fold increase in fatigue life. The fatigue life increase (in the flexural bending mode) with graphene additives was ∼1-2 orders of magnitude superior to those obtained using carbon nanotubes. In situ ultrasound analysis of the nanocomposite during the cyclic fatigue test suggests that the graphene network toughens the fiberglass/epoxy-matrix interface and prevents the delamination/buckling of the glass microfibers under compressive stress. Such fatigue-resistant hierarchical materials show potential to improve the safety, reliability, and cost effectiveness of fiber-reinforced composites that are increasingly the material of choice in the aerospace, automotive, marine, sports, biomedical, and wind energy industries. PMID:20863061

  10. State Test Score Trends through 2008-09, Part 4: Is Achievement Improving and Are Gaps Narrowing for Title I Students?

    ERIC Educational Resources Information Center

    Kober, Nancy; McMurrer, Jennifer; Silva, Malini R.

    2011-01-01

    Title I provides extra instructional services designed to raise achievement for low-performing students in schools with relatively high poverty rates, and for all students in many of the nation's highest-poverty schools. To learn more about how well Title I students are performing academically, the Center on Education Policy (CEP) compared…

  11. Does Self-Regulated Learning-Skills Training Improve High-School Students' Self-Regulation, Math Achievement, and Motivation While Using an Intelligent Tutor?

    ERIC Educational Resources Information Center

    Barrus, Angela

    2013-01-01

    This study empirically evaluated the effectiveness of the instructional design, learning tools, and role of the teacher in three versions of a semester-long, high-school remedial Algebra I course to determine what impact self-regulated learning skills and learning pattern training have on students' self-regulation, math achievement, and…

  12. Project LEAP: The Labor Education Achievement Program. A Program To Improve the Literacy Level and Productivity of the Workforce. Final Project Report. April 1, 1991-September 30, 1992.

    ERIC Educational Resources Information Center

    Metropolitan Baltimore Council of AFL-CIO Unions, MD.

    Maryland's Labor Education Achievement Program (LEAP) worked with a wide diversity of union workers in multiple industries and within numerous private companies and public agencies over a dispersed geographic area. Staff development included a workshop for local coordinators and a teacher inservice training session. LEAP provided…

  13. An Augmented Reality-Based Mobile Learning System to Improve Students' Learning Achievements and Motivations in Natural Science Inquiry Activities

    ERIC Educational Resources Information Center

    Chiang, Tosti H. C.; Yang, Stephen J. H.; Hwang, Gwo-Jen

    2014-01-01

    In this study, an augmented reality-based mobile learning system is proposed for conducting inquiry-based learning activities. An experiment has been conducted to examine the effectiveness of the proposed approach in terms of learning achievements and motivations. The subjects were 57 fourth graders from two classes taught by the same teacher in…

  14. Using School Reform Models to Improve Reading Achievement: A Longitudinal Study of Direct Instruction and Success for All in an Urban District

    ERIC Educational Resources Information Center

    Ross, Steven M.; Nunnery, John A.; Goldfeder, Elizabeth; McDonald, Aaron; Rachor, Robert; Hornbeck, Matthew; Fleischman, Steve

    2004-01-01

    This research examined the effectiveness in an urban school district of 2 of the most widely used Comprehensive School Reform (CSR) programs-Direct Instruction (DI), implemented in 9 district elementary schools, and Success for All (SFA), implemented in 2 elementary schools. In examining impacts on student achievement and school change outcomes…

  15. A Class Size Reduction (CSR) Implementation Plan Based on an Evaluative Study of CSRs for the Improvement of Third Grade Reading Achievement

    ERIC Educational Resources Information Center

    Vandyke, Barbara Adrienne

    2009-01-01

    For too long, educators have been left to their own devices when implementing educational policies, initiatives, strategies, and interventions, and they have longed to see the full benefits of these programs, especially in reading achievement. However, instead of determining whether a policy/initiative is working, educators have been asked to…

  16. The Daily Disciplines of Leadership: How To Improve Student Achievement, Staff Motivation, and Personal Organization. The Jossey-Bass Education Series.

    ERIC Educational Resources Information Center

    Reeves, Douglas B.

    This guide is intended to be a practical primer to help education leaders meet the daily challenges of school leadership. It shows how to include leadership in an integrated system of educational accountability, teaching, and curriculum for student achievement; how to do away with ineffective, obsolete, and unnecessary practices; and how to…

  17. The Economic Benefits of Closing Educational Achievement Gaps: Promoting Growth and Strengthening the Nation by Improving the Educational Outcomes of Children of Color

    ERIC Educational Resources Information Center

    Lynch, Robert G.; Oakford, Patrick

    2014-01-01

    Our nation is currently experiencing growing levels of income and wealth inequality, which are contributing to longstanding racial and ethnic gaps in education outcomes and other areas. This report quantifies the economic benefits of closing one of the most harmful racial and ethnic gaps: the educational achievement gap that exists between black…

  18. Use of Rasch Rating Scale Modeling to Develop and Validate a Measure of District-Level Characteristics and Practices Identified to Improve Instruction and Increase Student Achievement

    ERIC Educational Resources Information Center

    Soska, Paul J., III

    2012-01-01

    Increasing qualitative evidence in the literature supports specific characteristics and practices, presented from a distributed leadership perspective, to be prevalent in school districts that demonstrate significant increases in student achievement. Quantitative evidence linking these identified district-level characteristics and practices to…

  19. Examining School Improvement through the Lens of Principal and Teacher Flow of Influence in High-Achieving, High-Poverty Schools

    ERIC Educational Resources Information Center

    Murley, Lisa Downing; Keedy, John L.; Welsh, John F.

    2008-01-01

    Based on the social exchange theory of Homans, Gouldner, and Malinowski, this sociocultural analysis of three elementary schools focused on principal-teacher and teacher-teacher exchanges of instructional influence. Two questions were asked: (a) In what ways, if any, do principals and teachers in high-achieving, high-poverty schools exchange…

  20. School Improvement in Petersburg: A Comprehensive Three-Year Study of the Partnership for Achieving Successful Schools Initiative Model IV Intervention. Final Evaluation Report

    ERIC Educational Resources Information Center

    Edwards, Joanna; Smith, Karen; Marr, Linda; Wyshynski, Laura

    2005-01-01

    Dr. Jo Lynne DeMary, Virginia's state superintendent of public instruction, requested that the Appalachia Educational Laboratory at Edvantia work in partnership with the Virginia Department of Education and Petersburg City Schools to design and test the Partnership for Achieving Successful Schools Initiative (PA+SS) Model IV Intervention. The goal…

  1. Is It Possible to Improve Mathematical Achievement by Means of Self-Regulation Strategies? Evaluation of an Intervention in Regular Math Classes

    ERIC Educational Resources Information Center

    Perels, Franziska; Dignath, Charlotte; Schmitz, Bernhard

    2009-01-01

    After the effectiveness of self-regulation training outside school was demonstrated, a self-regulation intervention was developed to foster the learning achievement in regular math classes. Based on the theoretical framework of self-regulated learning, self-regulation training was integrated into a math class unit. The evaluation of the…

  2. Closing the Gap: A Report on the Wingspread Conference "Beyond the Standards Horse Race: Implementation, Assessment, and Accountability--the Keys to Improving Student Achievement" (Racine, Wisconsin, November 2-4, 1999). Special Report.

    ERIC Educational Resources Information Center

    Duggan, Terri, Ed.; Holmes, Madelyn, Ed.

    This report highlights results from the 1999 Wingspread Conference on improving student achievement, a gathering of educators, leaders, and policymakers that opened a dialogue about barriers to full implementation of high standards for all students. Participants discussed five papers that examined these issues from top to bottom--from the…

  3. Improving Student Achievement through Technology. Hearing before the Subcommittee on 21st Century Competitiveness of the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, First Session (March 15, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

    The Subcommittee on 21st Century Competitiveness, Committee on Education and the Workforce to met on Thursday, March 15, 2001 at 10:06 a.m., in Room 2175, Rayburn House Office Building, Hon. Howard P. "Buck" McKeon, Chairman of the Subcommittee presiding, to hear testimony on the use of technology to improve student achievement.Under Committee…

  4. Testimony of Dr. Willard Sakiestewa Gilbert, President National Indian Education Association before the Education and Labor Subcommittee on Early Childhood, Elementary and Secondary Education on Challenges Facing Bureau of Indian Education Schools in Improving Student Achievement

    ERIC Educational Resources Information Center

    Gilbert, Willard Sakiestewa

    2008-01-01

    In this testimony, Dr. Willard Sakiestewa Gilbert talks on behalf of the National Indian Education Association with regard to the Bureau of Indian Education (BIE) and challenges facing BIE schools in improving student achievement. Founded in 1969, the National Indian Education Association (NIEA) is the largest organization in the nation dedicated…

  5. WWC Review of the Report "Closing the Social-Class Achievement Gap: A Difference-Education Intervention Improves First-Generation Students' Academic Performance and All Students' College Transition." What Works Clearinghouse Single Study Review

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    For the 2014 study, "Closing the Social-Class Achievement Gap: A Difference-Education Intervention Improves First-Generation Students' Academic Performance and All Students' College Transition," researchers investigated the impact of attending a moderated panel on incoming freshmen's adjustment to college. The panel…

  6. Closing the Achievement Gap by Improving Reading Instruction. Hearing before the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, First Session (Orlando, Florida, November 13, 2001).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

    A field hearing of the United States House of Representatives' Committee on Education and the Workforce, entitled "Closing the Achievement Gap by Improving Reading Instruction," was held at Lancaster Elementary School in Orlando, Florida, on November 13, 2001. The hearing begins with welcoming statements by the committee chairman and one of the…

  7. Improving the teaching and learning of science in a suburban junior high school on Long Island: Achieving parity through cogenerative dialogues

    NASA Astrophysics Data System (ADS)

    Baker, Eileen Perman

    The research in this dissertation focuses on ways to improve the teaching and learning of science in a suburban junior high school on Long Island, New York. The study is my attempt to find ways to achieve parity in my classroom in terms of success in science. I was specifically looking for ways to encourage Black female students in my classroom and in other classrooms to continue their science education into the upper grades. The participants were the 27 students in the class, a friend of one of the students, and I, as the teacher-researcher. In order to examine the ways in which structure mediates the social and historical contexts of experiences in relation to teacher and student practices in the classroom, I used collaborative research; autobiographical reflection; the sociology of emotions; immigration, racialization, and ethnicity, and cogenerative dialogues (cogens) as tools. Cogenerative dialogues are a way for students and teachers to accept shared responsibility for teaching and learning. This study is of importance because of my school's very diverse student body. The school has a large minority population and therefore shares many of the characteristics of urban schools. In my study I look at why there are so few Black female students in the advanced science courses offered by our district and how this problem can be addressed. I used a variety of qualitative approaches including critical ethnography and micro analysis to study the teaching and learning of science. In addition to the usual observational, methodological, and theoretical field notes, I videotaped and audiotaped lessons and had discussions with students and teachers, one-on-one and in groups. In the first year the cogenerative group consisted of two Black female students. In the second year of the study there were four Black and one White-Hispanic female students in the cogen group. In my research I studied the interactions of the students between lessons and during laboratory activities as

  8. Improving the teaching and learning of science in a suburban junior high school on Long Island: Achieving parity through cogenerative dialogues

    NASA Astrophysics Data System (ADS)

    Baker, Eileen Perman

    The research in this dissertation focuses on ways to improve the teaching and learning of science in a suburban junior high school on Long Island, New York. The study is my attempt to find ways to achieve parity in my classroom in terms of success in science. I was specifically looking for ways to encourage Black female students in my classroom and in other classrooms to continue their science education into the upper grades. The participants were the 27 students in the class, a friend of one of the students, and I, as the teacher-researcher. In order to examine the ways in which structure mediates the social and historical contexts of experiences in relation to teacher and student practices in the classroom, I used collaborative research; autobiographical reflection; the sociology of emotions; immigration, racialization, and ethnicity, and cogenerative dialogues (cogens) as tools. Cogenerative dialogues are a way for students and teachers to accept shared responsibility for teaching and learning. This study is of importance because of my school's very diverse student body. The school has a large minority population and therefore shares many of the characteristics of urban schools. In my study I look at why there are so few Black female students in the advanced science courses offered by our district and how this problem can be addressed. I used a variety of qualitative approaches including critical ethnography and micro analysis to study the teaching and learning of science. In addition to the usual observational, methodological, and theoretical field notes, I videotaped and audiotaped lessons and had discussions with students and teachers, one-on-one and in groups. In the first year the cogenerative group consisted of two Black female students. In the second year of the study there were four Black and one White-Hispanic female students in the cogen group. In my research I studied the interactions of the students between lessons and during laboratory activities as

  9. Title III Accountability and District Improvement Efforts: A Closer Look. ESEA Evaluation Brief: The English Language Acquisition, Language Enhancement, and Academic Achievement Act

    ERIC Educational Resources Information Center

    Tanenbaum, Courtney; Anderson, Lindsay

    2010-01-01

    "Title III Accountability and District Improvement Efforts: A Closer Look" (2010) summarizes findings from interviews with six Title III Directors and nine Title III district-level directors in the spring of 2009. States and districts were selected in order to collect information from some entities with a long history of serving English Learners…

  10. What Works Clearinghouse Quick Review of the Report "Exercise Improves Executive Function and Achievement and Alters Brain Activation in Overweight Children: A Randomized, Controlled Trial"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The study examined whether exercise offered to sedentary, overweight children ages 7 to 11 improved executive function--defined as strategy execution when presented with a novel task--and academic performance in reading and math. The study authors analyzed data on about 170 students from Georgia who were recruited in five cohorts from 2003 to…

  11. Southern Education and the American Recovery and Reinvestment Act: An Analysis of Historic Federal Funding to Improve the South's Low-Achieving Schools. Issue Brief

    ERIC Educational Resources Information Center

    Southern Education Foundation, 2009

    2009-01-01

    The new federal stimulus law, the American Recovery and Reinvestment Act of 2009 (ARRA), offers Southern states a historic opportunity to improve public education from pre-school through college especially for low income students. ARRA allocates over $100 billion directly to the 15 states of the South for creating jobs and spurring economic…

  12. The Rice coding algorithm achieves high-performance lossless and progressive image compression based on the improving of integer lifting scheme Rice coding algorithm

    NASA Astrophysics Data System (ADS)

    Jun, Xie Cheng; Su, Yan; Wei, Zhang

    2006-08-01

    In this paper, a modified algorithm was introduced to improve Rice coding algorithm and researches of image compression with the CDF (2,2) wavelet lifting scheme was made. Our experiments show that the property of the lossless image compression is much better than Huffman, Zip, lossless JPEG, RAR, and a little better than (or equal to) the famous SPIHT. The lossless compression rate is improved about 60.4%, 45%, 26.2%, 16.7%, 0.4% on average. The speed of the encoder is faster about 11.8 times than the SPIHT's and its efficiency in time can be improved by 162%. The speed of the decoder is faster about 12.3 times than that of the SPIHT's and its efficiency in time can be rasied about 148%. This algorithm, instead of largest levels wavelet transform, has high coding efficiency when the wavelet transform levels is larger than 3. For the source model of distributions similar to the Laplacian, it can improve the efficiency of coding and realize the progressive transmit coding and decoding.

  13. Reducing Stereotype Threat in Classrooms: A Review of Social-Psychological Intervention Studies on Improving the Achievement of Black Students. Summary. Issues & Answers. REL 2009-076

    ERIC Educational Resources Information Center

    Aronson, Joshua; Cohen, Geoffrey; McColskey, Wendy

    2009-01-01

    Stereotype threat arises from a fear among members of a group of reinforcing negative stereotypes about the intellectual ability of the group. This report identifies three randomized controlled trial studies that use classroom-based strategies to reduce stereotype threat and improve the academic performance of Black students, narrowing their…

  14. Reducing Stereotype Threat in Classrooms: A Review of Social-Psychological Intervention Studies on Improving the Achievement of Black Students. Issues & Answers. REL 2009-076

    ERIC Educational Resources Information Center

    Aronson, Joshua; Cohen, Geoffrey; McColskey, Wendy

    2009-01-01

    Stereotype threat arises from a fear among members of a group of reinforcing negative stereotypes about the intellectual ability of the group. This report identifies three randomized controlled trial studies that use classroom-based strategies to reduce stereotype threat and improve the academic performance of Black students, narrowing their…

  15. Hypnotherapy and Test Anxiety: Two Cognitive-Behavioral Constructs. The Effects of Hypnosis in Reducing Test Anxiety and Improving Academic Achievement in College Students.

    ERIC Educational Resources Information Center

    Sapp, Marty

    A two-group randomized multivariate analysis of covariance (MANCOVA) was used to investigate the effects of cognitive-behavioral hypnosis in reducing test anxiety and improving academic performance in comparison to a Hawthorne control group. Subjects were enrolled in a rigorous introductory psychology course which covered an entire text in one…

  16. Progress Made on a Plan To Integrate Planning, Budgeting, Assessment and Quality Principles To Achieve Institutional Improvement. First Year Report. AIR 1996 Annual Forum Paper.

    ERIC Educational Resources Information Center

    Griffith, Susan R.; And Others

    This paper describes first year implementation efforts of Southwest Texas (SWT) State University to develop a system to integrate planning, budgeting, assessment, and quality to improve the delivery of education and other services to all the institution's customers. The document addresses the common situation when an organization already has…

  17. The Effect of Improved School Climate over Time on Fifth-Grade Students' Achievement Assessment Scores and Teacher Administered Grade Scores

    ERIC Educational Resources Information Center

    Marten, Dawn M.

    2012-01-01

    The purpose of the study was to determine the effect of improved school climate, as teachers' beliefs changed from negative to positive over time, on students' reading, math, and writing assessment scores and teacher administered grade scores in reading, math, and writing. Overall, findings indicate that lose, maintain, or improve…

  18. Dramatic Expression in Opera, and Its Implications for Conversational Agents. Chapter 7

    NASA Technical Reports Server (NTRS)

    Johnson, W. Lewis

    2007-01-01

    This article has discussed principles, techniques, and methods of dramatic portrayal in opera, and their application to the development of embodied conversational agents. Investigations such as this complement studies of natural human behavior, and offer insights as to how to make such behavior understandable and interesting when adapted for use by embodied conversational agents. However, one should use caution in applying such lessons. The unique characteristics of computer-based media are still being identified and explored. In any case, one must always be careful about applying principles blindly to any artistic form. Such principles are post-hoc analysis of the intuitive skill of great artists; this was as true in Aristotle's day as it is today. We should not let structural principles stand in the way of injecting creativity into the design of ECAs. Opera at its best possesses an element of magic that is difficult to describe, much less analytically reconstruct. We can only hope to achieve a similar result with conversational agents.

  19. Implementation of the Peer-Led Team-Learning Instructional Model as a Stopgap Measure Improves Student Achievement for Students Opting Out of Laboratory

    PubMed Central

    Snyder, Julia J.; Carter, B. Elijah; Wiles, Jason R.

    2015-01-01

    In entry-level university courses in science, technology, engineering, and mathematics fields, students participating in associated laboratory sessions generally do better than those who have no related lab classes. This is a problem when, for various reasons, not enough lab sections can be offered for students and/or when students opt out of optional available lab courses. Faced with such a situation, this study evaluated the efficacy of the peer-led team-learning (PLTL) instructional model as a potential method for narrowing the achievement gap among undergraduate students electing not to enroll in an optional laboratory component of an introductory biology course. In peer-led workshops, small groups of students participated in solving problems and other activities that encouraged active learning. Students led by peer leaders attained significantly higher exam and final course grades in introductory biology than comparable students not participating in PLTL. Among the introductory biology students who opted not to enroll in the optional lab course, those who participated in PLTL averaged more than a letter grade higher than those who did not. This difference was statistically significant, and the PLTL workshops almost entirely closed the achievement gap in lecture exam and final grades for students who did not take the lab. PMID:25673354

  20. Implementation of the peer-led team-learning instructional model as a stopgap measure improves student achievement for students opting out of laboratory.

    PubMed

    Snyder, Julia J; Carter, B Elijah; Wiles, Jason R

    2015-03-01

    In entry-level university courses in science, technology, engineering, and mathematics fields, students participating in associated laboratory sessions generally do better than those who have no related lab classes. This is a problem when, for various reasons, not enough lab sections can be offered for students and/or when students opt out of optional available lab courses. Faced with such a situation, this study evaluated the efficacy of the peer-led team-learning (PLTL) instructional model as a potential method for narrowing the achievement gap among undergraduate students electing not to enroll in an optional laboratory component of an introductory biology course. In peer-led workshops, small groups of students participated in solving problems and other activities that encouraged active learning. Students led by peer leaders attained significantly higher exam and final course grades in introductory biology than comparable students not participating in PLTL. Among the introductory biology students who opted not to enroll in the optional lab course, those who participated in PLTL averaged more than a letter grade higher than those who did not. This difference was statistically significant, and the PLTL workshops almost entirely closed the achievement gap in lecture exam and final grades for students who did not take the lab. PMID:25673354

  1. Dramatic Photosynthesis.

    ERIC Educational Resources Information Center

    Carlsson, Britta

    2003-01-01

    Presents a creative way to teach photosynthesis. Revolves around the growth of a lily planted and stored in the classroom. Combines the concepts of particle theory, transformation, and changes of phase and mass in a holistic approach. The six-step teaching sequence is founded on the notions of challenge, variation, and drama. (Author/NB)

  2. Resonant Ionization Laser Ion Source (RILIS) With Improved Selectivity Achieved By Ion Pulse Compression Using In-Source Time-of-flight Technique

    SciTech Connect

    Mishin, V. I.; Malinovsky, A. L.; Mishin, D. V.

    2009-03-17

    This paper describes for the first time the improved selectivity of the RILIS made possible by the time-of-flight (TOF) ion bunch compression. Brief description of the compression principles and some preliminary experimental results are presented. In the off-line experiments short ion peaks of natural Li, Na, K, Tm and Yb are observed as ions leave the RILIS-TOF structure. For Tm the ion peaks of 5 {mu}s half-height duration are detected and 1 {mu}s peaks for Sn are predicted. In view of the repetition rate of the ISOLDE-RILIS lasers it is hoped that the selectivity of Sn isotopes production may be improved as much as 100 employing the RILIS with the TOF ion bunch compression and a gating technique.

  3. Greater years of maternal schooling and higher scores on academic achievement tests are independently associated with improved management of child diarrhea by rural Guatemalan mothers.

    PubMed

    Webb, Aimee L; Ramakrishnan, Usha; Stein, Aryeh D; Sellen, Daniel W; Merchant, Moeza; Martorell, Reynaldo

    2010-09-01

    Appropriate home management can alleviate many of the consequences of diarrhea including malnutrition, impaired development, growth faltering, and mortality. Maternal cognitive ability, years of schooling, and acquired academic skills are hypothesized to improve child health by improving maternal child care practices, such as illness management. Using information collected longitudinally in 1996-1999 from 466 rural Guatemalan women with children <36 months, we examined the independent associations between maternal years of schooling, academic skills, and scores on the Raven's Progressive Matrices and an illness management index (IMI). Women scoring in the lowest and middle tertiles of academic skills scored lower on the IMI compared to women in the highest tertile (-0.24 [95% CI: -0.54, 0.07]; -0.30 [95% CI: -0.54, -0.06], respectively) independent of sociodemographic factors, schooling, and Raven's scores. Among mothers with less than 1 year of schooling, scoring in the lowest tertile on the Raven's Progressive Matrices compared to the highest was significantly associated with scoring one point lower on the IMI (-1.18 [95% CI: -2.20, -0.17]). Greater academic skills were independently associated with maternal care during episodes of infant diarrhea. Schooling of young girls and/or community based programs that provide women with academic skills such as literacy, numeracy and knowledge could potentially improve mothers' care giving practices. PMID:19685178

  4. Achieving performance breakthroughs in an HMO business process through quality planning.

    PubMed

    Hanan, K B

    1993-01-01

    Kaiser Permanente's Georgia Region commissioned a quality planning team to design a new process to improve payments to its suppliers and vendors. The result of the team's effort was a 73 percent reduction in cycle time. This team's experiences point to the advantages of process redesign as a quality planning model, as well as some general guidelines for its most effective use in teams. If quality planning project teams are carefully configured, sufficiently expert in the existing process, and properly supported by management, organizations can achieve potentially dramatic improvements in process performance using this approach. PMID:10130708

  5. Guiding the Noticing: Using a Dramatic Performance Experience to Promote Tellability in Narrative Writing

    ERIC Educational Resources Information Center

    Clark, Shanetia

    2012-01-01

    In this article, the author describes her use of dramatic performance to promote tellability in narrative writing within a seventh and eighth grade English and language arts classroom. By experiencing dramatic performance, the students were able to actively and physically perform the writing process: brainstorming, drafting, revising, and editing.…

  6. Using Creative Dramatics to Teach Conflict Resolution: Exploiting the Drama/Conflict Dialectic.

    ERIC Educational Resources Information Center

    Pipkin, Will; DiMenna, Stephen

    1989-01-01

    Discusses the dialectic between creative dramatics and conflict resolution and its exploration by the Conflict Resolution Project (CRP). Outlines the CRP's perspectives and general approach as a prelude to a more indepth review about how creative dramatics are used by the CRP. (Author/NB)

  7. "I Did Not Wash My Feet with that Woman": Using Dramatic Performance to Teach Biblical Studies

    ERIC Educational Resources Information Center

    Torbett, David

    2010-01-01

    The student dramatic performance is an effective way for undergraduates to learn biblical studies. In this article I will give an example of a dramatic performance assignment that I developed over a number of courses and used most recently and most successfully in an undergraduate course in the Hebrew Bible at a small liberal arts college in the…

  8. The Influence of the Physical Design of the Dramatic Play Center on Children's Play.

    ERIC Educational Resources Information Center

    Petrakos, Harriet; Howe, Nina

    1996-01-01

    Observed the effects of dramatic play center variations on children's social and cognitive play behaviors. Found that solitary-designed centers facilitated more solitary play than group-designed centers; dramatic play increased in the intervention and follow-up housekeeping centers compared to the baseline housekeeping center; and thematic centers…

  9. The Ecology of Dramatic Play Centers and Children's Social and Cognitive Play.

    ERIC Educational Resources Information Center

    Howe, Nina; And Others

    1993-01-01

    Used traditional housekeeping and novel dramatic play centers to compare the effects of theme, novelty, and duration on the social and cognitive play of two- to five-year olds. More dramatic play was observed in centers that used familiar rather than unfamiliar themes. Girls preferred traditional to novel centers; boys preferred novel to…

  10. Use of Dramatization to Teach Cardiac Cycle Physiology to Medical Students

    ERIC Educational Resources Information Center

    Dowlati, Ehsan; Musick, David W.; Zhang, Lin; Thornton, Katherine; Carvalho, Helena

    2016-01-01

    Part of the educator's mission is to develop new methodologies that promote active learning. This study examines the use of dramatization of the cardiac cycle in medical school. Two groups (n = 42, 21 each) of first-year medical students participated. Group A was initially taught through dramatization alone, while Group B was taught through…

  11. Enhancing Creative Dramatic Play and Story Reenactments in a Primary Grade Classroom.

    ERIC Educational Resources Information Center

    Schierholt, Carla G.

    A classroom research project in Alaska explored what role dramatic play and story reenactments have as a teaching/learning method for young childrens' development. A review of the literature identified several common elements that helped teachers elicit successful dramatic story reenactments: choosing a familiar book or story; encouraging…

  12. Receta para el Exito. Una Guia Actualizada para Padres sobre el Mejoramiento de las Escuelas de Colorado y Logros Estudiantiles (Recipe for Success: An Updated Parents' Guide to Improving Colorado Schools and Student Achievement).

    ERIC Educational Resources Information Center

    Taher, Bonnie; Durr, Pamela

    This Spanish language guide describes ways that parents can help improve student achievement and school quality. It answers such questions as: how to choose the right early-education opportunity for a preschooler; how to make sure a 5-year-old is ready for school; how to help a daughter do well in school; how to work with a daughter's or son's…

  13. In pursuit of high-value healthcare: the case for improving quality and achieving equity in a time of healthcare transformation.

    PubMed

    Betancourt, Joseph R

    2014-01-01

    The passage of the Patient Protection and Affordable Care Act and current efforts in payment reform signal the beginning of a significant transformation for the US healthcare system. As we embark on this transformation, disparities have emerged as the hallmark of low-value healthcare--care that does not meet quality standards, is inefficient, and is usually of high cost. A new set of structures is being developed to facilitate increased access to care that is cost-effective and high in quality--otherwise known as high-value healthcare. Addressing disparities and achieving equity are the perfect target areas for recouping value, and doing so will pave the way for high-value healthcare. As healthcare leaders make difficult choices, they should consider the realities of healthcare equity. First, racial and ethnic disparities in healthcare persist and are a clear sign of poor-quality, low-value healthcare. Second, the root causes of these disparities are complex, but a well-developed set of evidence-based approaches is available to help leaders address healthcare inequity. Third, evidence suggests that being inattentive to the root causes of disparities adversely affects efficiency and an organization's bottom line. Finally, if healthcare organizations are progressive, thoughtful, and prepared for success in such an environment, a new healthcare system that offers accessible, high-value, equitable, culturally competent, and high-quality care to all is well within reach. PMID:25291891

  14. Improved methods for achieving the equilibrium number of phases in mixtures suitable for use in battery electrodes e. g. , for lithiating FeS/sub 2/

    DOEpatents

    Guidotti, R.A.

    1986-06-10

    A method is disclosed for preparing lithiated, particulate FeS/sub 2/ useful as a catholyte material in a lithium thermal battery, whereby the latter's voltage regulation properties are improved. The method comprises admixing FeS/sub 2/ and an amount of a lithium-containing compound, whereby the resultant total composition falls in an invariant region of the metallurgical phase diagram of its constituent components. Said lithium-containing compound and FeS/sub 2/ are admixed together with a solid electrolyte compatible with said catholyte, and the mixture is heated at a temperature above the melting point of said electrolyte and at which said mixture reaches its thermodynamic equilibrium number of phases.

  15. An improved characterization method for international accountancy measurements of fresh and irradiated mixed oxide (MOX) fuel: helping achieve continual monitoring and safeguards through the fuel cycle

    SciTech Connect

    Evans, Louise G; Croft, Stephen; Swinhoe, Martyn T; Tobin, S. J.; Menlove, H. O.; Schear, M. A.; Worrall, Andrew

    2011-01-13

    Nuclear fuel accountancy measurements are conducted at several points through the nuclear fuel cycle to ensure continuity of knowledge (CofK) of special nuclear material (SNM). Non-destructive assay (NDA) measurements are performed on fresh fuel (prior to irradiation in a reactor) and spent nuclear fuel (SNF) post-irradiation. We have developed a fuel assembly characterization system, based on the novel concept of 'neutron fingerprinting' with multiplicity signatures to ensure detailed CofK of nuclear fuel through the entire fuel cycle. The neutron fingerprint in this case is determined by the measurement of the various correlated neutron signatures, specific to fuel isotopic composition, and therefore offers greater sensitivity to variations in fissile content among fuel assemblies than other techniques such as gross neutron counting. This neutron fingerprint could be measured at the point of fuel dispatch (e.g. from a fuel fabrication plant prior to irradiation, or from a reactor site post-irradiation), monitored during transportation of the fuel assembly, and measured at a subsequent receiving site (e.g. at the reactor site prior to irradiation, or reprocessing facility post-irradiation); this would confirm that no unexpected changes to the fuel composition or amount have taken place during transportation and/ or reactor operations. Changes may indicate an attempt to divert material for example. Here, we present the current state of the practice of fuel measurements for both fresh mixed oxide (MOX) fuel and SNF (both MOX and uranium dioxide). This is presented in the framework of international safeguards perspectives from the US and UK. We also postulate as to how the neutron fingerprinting concept could lead to improved fuel characterization (both fresh MOX and SNF) resulting in: (a) assured CofK of fuel across the nuclear fuel cycle, (b) improved detection of SNM diversion, and (c) greater confidence in safeguards of SNF transportation.

  16. An improved characterization method for international accountancy measurements of fresh and irradiated mixed oxide (MOX) fuel: helping achieve continual monitoring and safeguards through the fuel cycle

    SciTech Connect

    Evans, Louise G; Croft, Stephen; Swinhoe, Martyn T; Tobin, S. J.; Boyer, B. D.; Menlove, H. O.; Schear, M. A.; Worrall, Andrew

    2010-11-24

    Nuclear fuel accountancy measurements are conducted at several points through the nuclear fuel cycle to ensure continuity of knowledge (CofK) of special nuclear material (SNM). Non-destructive assay (NDA) measurements are performed on fresh fuel (prior to irradiation in a reactor) and spent nuclear fuel (SNF) post-irradiation. We have developed a fuel assembly characterization system, based on the novel concept of 'neutron fingerprinting' with multiplicity signatures to ensure detailed CofK of nuclear fuel through the entire fuel cycle. The neutron fingerprint in this case is determined by the measurement of the various correlated neutron signatures, specific to fuel isotopic composition, and therefore offers greater sensitivity to variations in fissile content among fuel assemblies than other techniques such as gross neutron counting. This neutron fingerprint could be measured at the point of fuel dispatch (e.g. from a fuel fabrication plant prior to irradiation, or from a reactor site post-irradiation), monitored during transportation of the fuel assembly, and measured at a subsequent receiving site (e.g. at the reactor site prior to irradiation, or reprocessing facility post-irradiation); this would confirm that no unexpected changes to the fuel composition or amount have taken place during transportation and/or reactor operations. Changes may indicate an attempt to divert material for example. Here, we present the current state of the practice of fuel measurements for both fresh mixed oxide (MOX) fuel and SNF (both MOX and uranium dioxide). This is presented in the framework of international safeguards perspectives from the US and UK. We also postulate as to how the neutron fingerprinting concept could lead to improved fuel characterization (both fresh MOX and SNF) resulting in: (a) assured CofK of fuel across the nuclear fuel cycle, (b) improved detection of SNM diversion, and (c) greater confidence in safeguards of SNF transportation.

  17. 25OHD analogues and vacuum blood collection tubes dramatically affect the accuracy of automated immunoassays.

    PubMed

    Yu, Songlin; Cheng, Xinqi; Fang, Huiling; Zhang, Ruiping; Han, Jianhua; Qin, Xuzhen; Cheng, Qian; Su, Wei; Hou, Li'an; Xia, Liangyu; Qiu, Ling

    2015-01-01

    Variations in vitamin D quantification methods are large, and influences of vitamin D analogues and blood collection methods have not been systematically examined. We evaluated the effects of vitamin D analogues 25OHD2 and 3-epi 25OHD3 and blood collection methods on vitamin D measurement, using five immunoassay systems and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Serum samples (332) were selected from routine vitamin D assay requests, including samples with or without 25OHD2 or 3-epi 25OHD3, and analysed using various immunoassay systems. In samples with no 25OHD2 or 3-epi 25OHD3, all immunoassays correlated well with LC-MS/MS. However, the Siemens system produced a large positive mean bias of 12.5 ng/mL and a poor Kappa value when using tubes with clot activator and gel separator. When 25OHD2 or 3-epi 25OHD3 was present, correlations and clinical agreement decreased for all immunoassays. Serum 25OHD in VACUETTE tubes with gel and clot activator, as measured by the Siemens system, produced significantly higher values than did samples collected in VACUETTE tubes with no additives. Bias decreased and clinical agreement improved significantly when using tubes with no additives. In conclusion, most automated immunoassays showed acceptable correlation and agreement with LC-MS/MS; however, 25OHD analogues and blood collection tubes dramatically affected accuracy. PMID:26420221

  18. 25OHD analogues and vacuum blood collection tubes dramatically affect the accuracy of automated immunoassays

    PubMed Central

    Yu, Songlin; Cheng, Xinqi; Fang, Huiling; Zhang, Ruiping; Han, Jianhua; Qin, Xuzhen; Cheng, Qian; Su, Wei; Hou, Li’an; Xia, Liangyu; Qiu, Ling

    2015-01-01

    Variations in vitamin D quantification methods are large, and influences of vitamin D analogues and blood collection methods have not been systematically examined. We evaluated the effects of vitamin D analogues 25OHD2 and 3-epi 25OHD3 and blood collection methods on vitamin D measurement, using five immunoassay systems and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Serum samples (332) were selected from routine vitamin D assay requests, including samples with or without 25OHD2 or 3-epi 25OHD3, and analysed using various immunoassay systems. In samples with no 25OHD2 or 3-epi 25OHD3, all immunoassays correlated well with LC-MS/MS. However, the Siemens system produced a large positive mean bias of 12.5 ng/mL and a poor Kappa value when using tubes with clot activator and gel separator. When 25OHD2 or 3-epi 25OHD3 was present, correlations and clinical agreement decreased for all immunoassays. Serum 25OHD in VACUETTE tubes with gel and clot activator, as measured by the Siemens system, produced significantly higher values than did samples collected in VACUETTE tubes with no additives. Bias decreased and clinical agreement improved significantly when using tubes with no additives. In conclusion, most automated immunoassays showed acceptable correlation and agreement with LC-MS/MS; however, 25OHD analogues and blood collection tubes dramatically affected accuracy. PMID:26420221

  19. Leaks can dramatically decrease FiO2 on home ventilators: a bench study

    PubMed Central

    2013-01-01

    Background Long term oxygen therapy improves survival in hypoxemic patients with chronic obstructive pulmonary disease (COPD). Because pressure support ventilation with a home care ventilator is largely unsupervised, there is considerable risk of leakage occurring, which could affect delivered FiO2. We have therefore conducted a bench study in order to measure the effect of different levels of O2 supply and degrees of leakage on delivered FiO2. Ventilator tested: Legendair® (Airox™, Pau, France). Thirty-six measures were performed in each four ventilators with zero, 5 and 10 l.min-1 leakage and 1,2,4 and 8 l O2 flow. Findings FiO2 decreased significantly with 5 l.min-1 leakage for all O2 flow rates, and with 10 l.min-1 at 4 and 8 l.min-1 O2. Conclusion During application of NIV on home ventilators, leakage can dramatically decrease inspired FiO2 making it less effective. It is important to know the FiO2 dispensed when NIV is used for COPD at home. We would encourage industry to develop methods for FiO2 regulation Chronic use of NIV for COPD with controlled FiO2 or SpO2 requires further studys. PMID:23870165

  20. The temperature of flash-cooling has dramatic effects on the diffraction quality of nucleosome crystals.

    PubMed

    Edayathumangalam, Rajeswari S; Luger, Karolin

    2005-07-01

    Nucleosome core-particle crystals are routinely flash-cooled in liquid propane at temperatures of approximately 153 K, followed by transfer into a cold nitrogen-gas stream (approximately 93 K). Analysis of diffraction data from crystals flash-cooled at different temperatures shows that the optimal temperature is approximately 153 K. The data quality worsens, with a concomitant reduction in the diffraction limit, at temperatures both higher and lower than 153 K. With some batches of crystals, significant shrinkage of the unit-cell volume is also observed at temperatures of 138 K and lower. The lattice shrinkage is always restricted to the c axis, concurrent with closer packing of two nucleosomes. Direct plunge-cooling of crystals in liquid nitrogen leads to loss of diffraction quality and resolution limit. Thus, in cases where flash-cooling into liquid nitrogen is detrimental to diffraction, optimizing cooling protocols at higher temperatures using liquid propane or other cryogens with similar properties may lead to dramatically improved results. In a related study, it is shown that a nucleosome crystal transported under 'cryocooled' conditions has higher mosaicity and yields inferior data quality in comparison to a crystal cryocooled at the synchrotron. For fragile crystals, transport in mother liquor and/or cryoprotectant followed by subsequent flash-cooling at the synchrotron may be the best procedure. PMID:15983411

  1. Reaction of amines with 8-methylthioBODIPY: dramatic optical and laser response to amine substitution.

    PubMed

    Esnal, Ixone; Urías-Benavides, Arlette; Gómez-Durán, C F Azael; Osorio-Martínez, Carlos A; García-Moreno, Inmaculada; Costela, Angel; Bañuelos, Jorge; Epelde, Nerea; López Arbeloa, Iñigo; Hu, Rongrong; Tang, Ben Zhong; Peña-Cabrera, Eduardo

    2013-11-01

    A thorough study of the photophysical and laser properties of 8-aminoboron dipyrromethene dyes was undertaken to determine the role of amine substitution and spatial disposition on the properties of the dyes. It was found that the fluorescent and laser response varied significantly. Although primary amines give rise to highly fluorescent products at the blue edge of the visible region, secondary amines yield nonfluorescent analogues in polar media. The crystal structures of two analogues are reported and described. Steric hindrance and the higher electron-releasing ability of the amine favor the formation of a quenching intramolecular charge-transfer state. Accordingly, boron dipyrromethene derivatives with primary amines exhibited laser emission with efficiencies of up to 44%. Besides, the more efficient derivative was also the most photostable, leading to a significant improvement in the lasing performance with regard to previously reported 8-aminoboron dipyrromethene derivatives. An increase in the solvent polarity, and mainly the presence of tertiary cyclic amines, led to a dramatic decrease or even the loss of the laser action. PMID:23956141

  2. Improved continuity of reduced graphene oxide on polyester fabric by use of polypyrrole to achieve a highly electro-conductive and flexible substrate

    NASA Astrophysics Data System (ADS)

    Berendjchi, Amirhosein; Khajavi, Ramin; Yousefi, Ali Akbar; Yazdanshenas, Mohammad Esmail

    2016-02-01

    A flexible and highly conductive fabric can be applied for wearable electronics and as a pliable counter electrode for photovoltaics. Methods such as surface coating of fabrics with conductive polymers and materials have been developed, but the roughness of fabric is a challenge because it creates discontinuity in the coated layer. The present study first coated polyethylene terephthalate (PET) fabric with reduced graphene oxide sheets; RGO and then filled the gaps with polypyrrole (PPy). The samples were first dipped in graphene oxide (GO) and then reduced to RGO. They were next coated with PPy by in situ polymerization. The results showed that the presence of oxidative agent during synthesis of PPy oxidized the RGO to some extent on the previously RGO-coated samples. PPy was more uniform on samples pre-coated with RGO in comparison those coated with raw PET. The RGO-PPy coated samples exhibited 53% and 263% lower surface resistivity values than samples coated only with PPy and RGO, respectively. There was no significant difference between the tenacity of samples but the bending rigidity of samples increased. The RGO-PPy coated fabric displayed properties, such as excellent UV blocking (UPF = 73), antibacterial activity, improved electrochemical behavior and thermal stability which make it a multifunctional fabric.

  3. Comment and Response: A Relation of Agency to Act in Dramatism: A Comment on "Burke's Act."

    ERIC Educational Resources Information Center

    College English, 1985

    1985-01-01

    Presents a criticism of Clayton W. Lewis's analysis of Burke's "A Rhetoric of Motives" arguing that Lewis risks overstressing act and neglecting the necessary connection between agency and act in Burke's theory of dramatism. Includes Lewis's response. (HTH)

  4. The Interview: Dramatization Techniques in Dance--A New Approach to Teaching Modern Dance.

    ERIC Educational Resources Information Center

    Hamm, Gwendolyn Croom; Snygg, Fran

    1979-01-01

    The use of the interview dramatization as a teaching technique for presenting historical and chronological background information in the field of modern dance is described. Samples of the interviews are included. (JMF)

  5. A new treatment protocol using photobiomodulation and muscle/bone/joint recovery techniques having a dramatic effect on a stroke patient's recovery: a new weapon for clinicians

    PubMed Central

    Boonswang, N Ab; Chicchi, Mary; Lukachek, Adele; Curtiss, Donna

    2012-01-01

    The subject of this case study is a 29-year-old woman who suffered a brainstem stroke. She remained severely dizzy, had a non-functional left hand secondary to weakness, severe spasticity in the right hand, a right lateral sixth nerve palsy and was unable to ambulate on presentation. The stroke occurred 2 years before presentation. The subject had been treated for 21 months at two different stroke rehabilitation centres before presentation. Our stroke protocol includes photobiomodulation administered with the XR3T-1 device and ‘muscle/bone/joint/soft tissue’ recovery techniques. The patient was seen once a week for 8 weeks and treatment sessions lasted approximately 60 min. The results were dramatic: after 8 weeks of implementation of our protocol, the patient demonstrated positive change in every area of her deficits as determined by improvements in physical examination findings. The gains achieved at 8 weeks have been maintained to this day and she continues to be treated once every 4 weeks. PMID:22967677

  6. Moving Toward Universal Health Coverage (UHC) to Achieve Inclusive and Sustainable Health Development: Three Essential Strategies Drawn From Asian Experience Comment on "Improving the World's Health Through the Post-2015 Development Agenda: Perspectives from Rwanda".

    PubMed

    Xu, Ye; Huang, Cheng; Colón-Ramos, Uriyoán

    2015-01-01

    Binagwaho and colleagues' perspective piece provided a timely reflection on the experience of Rwanda in achieving the Millennium Development Goals (MDGs) and a proposal of 5 principles to carry forward in post-2015 health development. This commentary echoes their viewpoints and offers three lessons for health policy reforms consistent with these principles beyond 2015. Specifically, we argue that universal health coverage (UHC) is an integrated solution to advance the global health development agenda, and the three essential strategies drawn from Asian countries' health reforms toward UHC are: (1) Public financing support and sequencing health insurance expansion by first extending health insurance to the extremely poor, vulnerable, and marginalized population are critical for achieving UHC; (2) Improved quality of delivered care ensures supply-side readiness and effective coverage; (3) Strategic purchasing and results-based financing creates incentives and accountability for positive changes. These strategies were discussed and illustrated with experience from China and other Asian economies. PMID:26673477

  7. Progress on achieving the ICF conditions needed for high gain

    SciTech Connect

    Lindl, J.D.

    1988-12-23

    Progress during the past two years has moved us much closer to demonstrating the scientific and technological requirements for high gain ICF in the laboratory. This progress has been made possible by operating at the third harmonic of 1..mu..m light which dramatically reduces concern about hot electrons and by advances in diagnostics such as 100 ps x-ray framing cameras which greatly increase the data available from each experiment. Making use of many of these new capabilities, major improvements in confinement conditions have been achieved for ICF implosions. In particular, in an optimized hohlraum on Nova, radiation driven implosions with convergence ratio in excess of 30 (volume compression /approximately/3 /times/ 10/sup 4/) have performed essentially as predicted by spherical implosion calculations. This paper presents these results as well as examples of advances in several other areas and discusses the implications for the future of ICF with lasers and heavy ion beam drivers. 8 refs., 10 figs.

  8. Improving African American Achievement in Geometry Honors

    ERIC Educational Resources Information Center

    Mims, Adrian B.

    2010-01-01

    This case study evaluated the significance of implementing an enrichment mathematics course during the summer to rising African American ninth graders entitled, "Geometry Honors Preview." In the past, 60 to 70 percent of African American students in this school district had withdrawn from Geometry Honors by the second academic quarter. This study…

  9. Improving the Achievement of Minority Students.

    ERIC Educational Resources Information Center

    Murphy, John A.

    1988-01-01

    In 1984, a Maryland elementary school publicized standardized test scores showing black students trailing white students by 25 points. Alarmed by this gap, a district task force found the root cause--negative attitudes about black students' potential--and launched an effective schools process in 171 schools. Two supporting programs are described.…

  10. Computer Networks Improve Student Achievement, School Management.

    ERIC Educational Resources Information Center

    Cherry, Steve

    1991-01-01

    Using computer networking programs at two high schools as examples, this article describes what principals should know about networking. The many advantages of computer networking in schools will remain beneficial so long as the principal's objectives are met. Tips are provided for assessing the network. (eight references) (MLH)

  11. Dietary Measures to Improve Behavior and Achievement

    ERIC Educational Resources Information Center

    Powers, Hugh W. S., Jr.

    1973-01-01

    Reported are results of nutritional treatment (to correct deviant blood sugar curves) on the behavioral and academic performances of 260 children and young adults with wide ranges of learning and behavioral problems. (MC)

  12. Can Emphasising Cognitive Development Improve Academic Achievement?

    ERIC Educational Resources Information Center

    Pasnak, Robert; Kidd, Julie K.; Gadzichowski, Marinka K.; Gallington, Deborah A.; Saracina, Robin P.

    2008-01-01

    Background: Children ordinarily begin their formal education at the age when the great majority of them are capable of understanding the role of addition and subtraction in changing number. In determining critical differences they can apply the oddity principle--the first "pure" abstraction that children ever develop--understanding that when all…

  13. Factors Influencing Improved Student Achievement in Virginia

    ERIC Educational Resources Information Center

    Linehan, Patrick D.

    2012-01-01

    At the beginning of the last decade, Congress passed and President George W. Bush signed the No Child Left Behind (NCLB) Act of 2002. Key provisions of this act focused on holding schools accountable to ensure that all students met state established standards. In Virginia, the state Standards of Learning (SOL) assessments form the basis of…

  14. Improved Reading Achievement: It's Union Work.

    ERIC Educational Resources Information Center

    American Federation of Teachers, Washington, DC.

    This booklet discusses the importance of all students being guaranteed a carefully crafted and appropriately balanced approach to reading instruction. Section 1, "Beginning Reading Instruction," discusses variation and inequity in reading instruction and reading skills nationwide. The American Federation of Teachers (AFT) has made it a priority to…

  15. Graded Achievement, Tested Achievement, and Validity

    ERIC Educational Resources Information Center

    Brookhart, Susan M.

    2015-01-01

    Twenty-eight studies of grades, over a century, were reviewed using the argument-based approach to validity suggested by Kane as a theoretical framework. The review draws conclusions about the meaning of graded achievement, its relation to tested achievement, and changes in the construct of graded achievement over time. "Graded…

  16. The Phantom Collapse of Student Achievement in New York

    ERIC Educational Resources Information Center

    Cronin, John; Jensen, Nate

    2014-01-01

    When New York state released the first results of the exams under the Common Core State Standards, many wrongly believed that the results showed dramatic declines in student achievement. A closer look at the results showed that student achievement may have increased. Another lesson from the exams is that states need to closely coordinate new data…

  17. Dramatic reduction in process temperature of InGaN-based light-emitting diodes by pulsed sputtering growth technique

    NASA Astrophysics Data System (ADS)

    Nakamura, Eiji; Ueno, Kohei; Ohta, Jitsuo; Fujioka, Hiroshi; Oshima, Masaharu

    2014-02-01

    P-type doping of GaN by pulsed sputtering deposition (PSD) at a low growth temperature of 480 °C and dramatic reduction in the growth process temperature for InGaN-based light-emitting diodes (LEDs) were achieved. Mg-doped GaN layers grown on semi-insulating GaN at 480 °C exhibited clear p-type conductivity with a hole concentration and mobility of 3.0 × 1017 cm-3 and 3.1 cm2 V-1 s-1, respectively. GaN/In0.33Ga0.67N/GaN LEDs fabricated at 480 °C showed clear rectifying characteristics and a bright electroluminescence emission near 640 nm. These results indicate that this low temperature PSD growth technique is quite promising for the production of nitride-based light-emitting devices on large-area glass substrates.

  18. Bandwidth efficient coding: Theoretical limits and real achievements. Error control techniques for satellite and space communications

    NASA Technical Reports Server (NTRS)

    Costello, Daniel J., Jr.; Courturier, Servanne; Levy, Yannick; Mills, Diane G.; Perez, Lance C.; Wang, Fu-Quan

    1993-01-01

    In his seminal 1948 paper 'The Mathematical Theory of Communication,' Claude E. Shannon derived the 'channel coding theorem' which has an explicit upper bound, called the channel capacity, on the rate at which 'information' could be transmitted reliably on a given communication channel. Shannon's result was an existence theorem and did not give specific codes to achieve the bound. Some skeptics have claimed that the dramatic performance improvements predicted by Shannon are not achievable in practice. The advances made in the area of coded modulation in the past decade have made communications engineers optimistic about the possibility of achieving or at least coming close to channel capacity. Here we consider the possibility in the light of current research results.

  19. Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin.

    PubMed

    Wu, Jiajia; Gao, Bin; Zhu, Shunyi

    2016-07-01

    The emergence and rapid spread of multiresistant bacteria has lead to an urgent need for novel antimicrobials. Based on single-point substitutions, we generated a series of mutants of micasin, a dermatophytic defensin, with enhanced activities against multiple clinical isolates of Staphylococcus species, including 4 antibiotic-resistant strains. We first mapped the functional surface of micasin by alanine-scanning mutational analysis of its highly exposed residues, through which we found that substitution of site 8 (acidic Glu) dramatically enhanced bacterial killing of this peptide. Structural analysis indicates that this single point mutation could result in a functional local amphipathic architecture. Four different types of side chains (hydrophobic, cationic polar, neutral polar, and acidic polar) were introduced at site 8 to clarify the role of this local architecture in micasin function. The results show that all mutants displayed increased antibacterial activity with the exception of the acidic replacement. These mutants with enhanced activity exhibited low hemolysis and cytotoxicity and showed high serum stability, indicating their therapeutic potential. Our work represents the first example of structural fine-tuning to largely improve the antibacterial potency of a dermatophytic defensin.-Wu, J., Gao, B., Zhu, S. Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. PMID:27084888

  20. Recalcitrant eosinophilic pustular folliculitis of Ofuji with palmoplantar pustulosis: dramatic response to narrowband UVB phototherapy.

    PubMed

    Lim, Hua Liang; Chong, Wei-Sheng

    2012-08-01

    Eosinophilic pustular folliculitis of Ofuji is a recalcitrant disease typified by non-infective eosinophilic spongiosis involving the infundibular region of the hair follicle. We present a case of a 49-year-old Chinese man with known palmoplantar pustulosis and acrodermatitis continua of Hallopeau which was promptly resolved with methotrexate therapy. He returned with an erythematous papulopustular eruption with coalescence to annular plaques, occurring over the face, chest and back with active palmoplantar pustulation. Histology from skin biopsy of the palmar lesion was in keeping with palmoplantar psoriasis, while biopsy of the facial and truncal lesions revealed florid perifollicular eosinophilic congregation diagnostic of eosinophilic pustular folliculitis of Ofuji. Indomethacin was initiated with partial improvement of lesions with cyclical flares. A trial of narrowband ultraviolet-B phototherapy at a frequency of thrice weekly achieved sustained clearance of both eosinophilic pustular folliculitis and palmoplantar lesions. Indomethacin was tailed down and eventually discontinued with maintenance of narrowband ultraviolet-B therapy; this achieved successful control of the disease. PMID:23017177

  1. The Impact of Presence Versus Absence of Negative Consequences in Dramatic Portrayals of Alcohol Drinking.

    ERIC Educational Resources Information Center

    Bahk, C. Mo.

    1997-01-01

    Using dramatic media presentations, explores issues surrounding the absence of negative consequences in alcohol consumption. Results based on 211 participants indicate that exposure to portrayals of alcohol drinking with negative consequences elicits the least favorable attitudes toward drinking. Exposure to the same presentation, without the…

  2. Occupational Awareness through Dramatic Play: A Curriculum Guide for Primary Grades: Parts 1 and 2.

    ERIC Educational Resources Information Center

    Golden, Loretta

    Designed for grades K-3, the career education curriculum guide focuses on dramatic play to create an environment which will stimulate children to explore various occupations within the community. At the beginning of the program, the community includes only a few structures. As the students realize the need for more buildings and services, the…

  3. Examining Young Children's Perception toward Augmented Reality-Infused Dramatic Play

    ERIC Educational Resources Information Center

    Han, Jeonghye; Jo, Miheon; Hyun, Eunja; So, Hyo-jeong

    2015-01-01

    Amid the increasing interest in applying augmented reality (AR) in educational settings, this study explores the design and enactment of an AR-infused robot system to enhance children's satisfaction and sensory engagement with dramatic play activities. In particular, we conducted an exploratory study to empirically examine children's perceptions…

  4. Athenian and Shakespearean Tragedies in Oceania: Teaching Dramatic Literatures in Fiji

    ERIC Educational Resources Information Center

    Anae, Nicole

    2013-01-01

    This paper presents a theorised classroom-based narrative discussing the author's interdisciplinary approach to the teaching of English dramatic literatures--in particular, Sophocles' "Oedipus the King" and Shakespeare's "Macbeth"--to i-Taukei, Indo-Fijian and Pacific Islander tertiary students at a South Pacific…

  5. Collaborative College Playwriting and Performance: A Core Course "Trespassing" onto the Dramatic Arts

    ERIC Educational Resources Information Center

    Bedetti, Gabriella

    2015-01-01

    Arts integration is relevant in the context of the increased demand for creative thinkers in a global economy. However, reaching across disciplinary boundaries is less common in higher education. Arts integration is one way that a literature class can "trespass" onto the dramatic arts. This paper reports on a study of integrating the…

  6. Art-House Cinema, Avant-Garde Film, and Dramatic Modernism

    ERIC Educational Resources Information Center

    Cardullo, Bert

    2011-01-01

    In this article, the author talks about art-house cinema, avant-garde film, and dramatic modernism. He believes that the most important modes of film practice are art-house cinema and the avant-garde, both of which contrast with the classical Hollywood mode of film practice. While the latter is characterized by its commercial imperative, corporate…

  7. Teenagers' Significant Experiences in Aesthetic Areas: Some Empirical Observations Regarding the Role of Dramatic Art

    ERIC Educational Resources Information Center

    Finnas, Leif

    2008-01-01

    Fifteen sixteen-year-old Fenno-Swedish compulsory school pupils' descriptions and evaluations of significant, i.e. more or less "strong", experiences relating to dramatic art (film, theatre) were analysed and compared with reported experiences in other aesthetic areas (music, nature etc.). The drama area was represented in many experiences, but…

  8. Effects of Dramatized Depictions of Accidents on Grade School Children's Reception of Safety Guidelines.

    ERIC Educational Resources Information Center

    Omdahl, Becky L.; Cantor, Joanne

    A study examined a format for fear appeal messages that introduced a threat through one medium (i.e., a segment of dramatic television programming) and the recommended action through another medium (i.e., the verbal presentation of safety guidelines by an adult to a child). Subjects, 138 elementary school children from a middle-class elementary…

  9. "Welcome to Philadelphia": An Original Dramatization of Life in the 1780s.

    ERIC Educational Resources Information Center

    Stakes, Mary E.

    Teachers can create an interest in the founding period of U.S. history and present students with an authentic view of this time period through the presentation of this play. The dramatic pretense of the play is that the audience, by their presence, is part of the drama. The audience plays the part of travelers visiting a Philadelphia home in the…

  10. "Emergent Literacy and Dramatic Play in Early Education" by Jane Davidson. Book Review.

    ERIC Educational Resources Information Center

    Chapman, Marilyn L.

    2000-01-01

    Notes that Davidson's book provides an in-depth exploration of the contribution of dramatic play to emergent literacy and ways that teachers can implement play-based literacy learning. Maintains that the book has a balanced theoretical orientation, provides a sensitive treatment of intervention, presents a thoughtful treatment of oral and written…

  11. Some Therapeutic Uses of Dramatic Play with the Aggressive Child in the Preschool Classroom.

    ERIC Educational Resources Information Center

    Ginnane, Patrick

    The primary purpose of this master's thesis is to describe some therapeutic uses of dramatic play with the mildly aggressive preschool child. The child for whom the suggested play interventions are considered appropriate is characterized by sociality and attachment to both peers and adults, and is not chronically aggressive. After the first…

  12. Engaging in Dramatic Activities in English as a Foreign Language Classes at the University Level

    ERIC Educational Resources Information Center

    Algarra Carrasco, Victoria

    2012-01-01

    In this article, we discuss how, through dramatic activities, fiction and reality can work together to help the English as a Foreign language learner communicate in a more personal and meaningful way. The kind of activities proposed are designed to help engender a space where students can personally engage with each other in an atmosphere that is…

  13. Architectural Images through the Dual Lens of Picture Books and Creative Dramatics.

    ERIC Educational Resources Information Center

    Cleaver, Betty P.; And Others

    Introducing architectural concepts to children is a relatively new area of the curriculum for schools, whether elementary schools or high schools. The use of picture books and creative dramatics to encourage children to think about architecture is explored. In a few hours, a fourth-grade class considered the destruction and rebuilding of a…

  14. Erotic Language as Dramatic Action in Plays by Lyly and Shakespeare

    ERIC Educational Resources Information Center

    Knoll, Gillian

    2012-01-01

    This study closely examines the language of desire in the dramatic works of John Lyly and William Shakespeare, and argues that contemplative and analytical speeches about desire function as modes of action in their plays. Erotic speeches do more than express desire in a purely descriptive or perlocutionary capacity distinct from the action of the…

  15. Mantle of the Expert: Integrating Dramatic Inquiry and Visual Arts in Social Studies

    ERIC Educational Resources Information Center

    Johnson, Edric C.; Liu, Katrina; Goble, Kristin

    2015-01-01

    This article introduces the social studies field to Dorothy Heatchote's Mantle of Expert (MOE). MOE is a dramatic inquiry approach used in several subject areas and can work at all levels in the social studies curriculum. The authors go into the development of using this approach in an elementary and middle teacher education program. After sharing…

  16. Dramatic Science at Key Stage 1: Modelling Ideas within an Olympics Theme

    ERIC Educational Resources Information Center

    McGregor, Deb; Precious, Wendy

    2012-01-01

    Dramatic Science is an approach to teaching science that purposely places the children in thought-provoking situations where they need to apply their scientific understanding to decide how to act. Teachers can then apply drama techniques to help children develop and communicate their ideas. In this article, the authors share how modelling through…

  17. Lord Kelvin and the Age-of-the-Earth Debate: A Dramatization.

    ERIC Educational Resources Information Center

    Stinner, Art; Tecihman, Jurgen

    2003-01-01

    Presents a dramatization of a fictitious debate about the age of the earth that takes place at the Royal Institution, London, England, in the year 1872 among Sir William Thomson, T.H. Huxley, Sir Charles Lyell, and Hermann von Helmholtz. (Contains 17 references.) (Author/YDS)

  18. National Lighting Bureau Reports Dramatic Energy Savings Possible through Minor Lighting Modifications.

    ERIC Educational Resources Information Center

    College Store Journal, 1979

    1979-01-01

    Dramatic savings are possible by implementing minor modifications including: energy efficient light bulbs and tubes, ballasts, luminaires (fixtures), controls, operating practices, and revised maintenance. Many different changes can be made without affecting productivity, safety and security, visual comfort, aesthetic appeal, consumer discretion,…

  19. Identity transformation and a changed lifestyle following dramatic weight loss and body-contouring surgery: An exploratory study.

    PubMed

    Gilmartin, Jo; Long, Andrew; Soldin, Mark

    2015-10-01

    This article reports on two major quality-of-life perception changes for patients who had undergone plastic surgery following dramatic weight loss. The exploratory, qualitative study was undertaken with 20 patients from one teaching hospital. In-depth interviews were conducted, and a thematic analysis of the data was undertaken. The results provide unique glimpses of surgical consumption empowering and facilitating 'identity transformation', embracing improved physical function and enhanced self-esteem, confidence and quality of life, and a 'changed lifestyle'. For a minority, identity transformation was sometimes interrupted by 'identity lag', posing the need for additional health-care support throughout the adjustment process. The study provides additional insight into existing quantitative studies, adding to the body of knowledge in this area. PMID:24296742

  20. [I was born a woman, the life of Mame: the dramatization of intergenerational inclusion].

    PubMed

    Lasheras Amat, M del Pilar; Muriel Fernández, Rafael; Llamas Martínez, M Victoria; Hallaga Messari, Asmaa; Bitoden Yaka, Albert; Ndour, Mame Awa; Dieng, Ousseynou; Márquez Bernal, Victoriano; Sevillano, Manuel Garrido

    2010-01-01

    I was born a woman, the life of Mame is the dramatization a fictitious intergenerational story. However, the story is based on true events and the feelings of real immigrant women. The dramatization narrates the life of a woman, from the time her parents-who had recently emigrated from Senegal-settled in Andalusia, up to the adolescence of Mame's own daughter. The story is told with one person on stage who, through the use of three costume changes, plays three different generations of women: mother, daughter and granddaughter, with the video-recorded testimonies of other characters (a teacher and a midwife), who express their views of the host society against a background of African music and pictures of their native country. The present article describes their goals, such as communication in conferences, and includes a concise summary of the script, reflections on the process of integrating, and the evaluation made after a performance. PMID:20022142

  1. "Shadows of the heart": a dramatic video for the treatment resistance of spouse abusers.

    PubMed

    Stosny, S

    1994-11-01

    Successful intervention with spouse abusers, most of whom are ordered into treatment by the courts, must overcome formidable anger and resistance, often expressed by high attrition and scant participation in the group treatment process. The dramatic video "Shadows of the Heart" dissipates client resistance by providing internal motivation to control violent behavior. The video dramatizes spouse abuse from the viewpoint of a young boy, who as a man has become a spouse abuser. As clients experience compassion for the child witness to family violence, they learn to convert their habitual anger response into nonviolent actions. Developed to combat treatment resistance, the video presentation was tested in a randomized experiment with 106 male spouse abusers drawn from seven public and private agencies. Results indicate that the video presentation significantly increased attendance and participation in the group treatment process. PMID:7992138

  2. Dramatic reduction of read disturb through pulse width control in spin torque random access memory

    NASA Astrophysics Data System (ADS)

    Wang, Zihui; Wang, Xiaobin; Gan, Huadong; Jung, Dongha; Satoh, Kimihiro; Lin, Tsann; Zhou, Yuchen; Zhang, Jing; Huai, Yiming; Chang, Yao-Jen; Wu, Te-ho

    2013-09-01

    Magnetizations dynamic effect in low current read disturb region is studied both experimentally and theoretically. Dramatic read error rate reduction through read pulse width control is theoretically predicted and experimentally observed. The strong dependence of read error rate upon pulse width contrasts conventional energy barrier approach and can only be obtained considering detailed magnetization dynamics at long time thermal magnetization reversal region. Our study provides a design possibility for ultra-fast low current spin torque random access memory.

  3. Discrimination, developmental science, and the law: addressing dramatic shifts in civil rights jurisprudence.

    PubMed

    Levesque, Roger J R

    2014-01-01

    The civil rights movement fostered dramatic shifts in legal responses to discrimination based on race, gender, and a host of other group characteristics. The legal system now evinces yet another dramatic shift, as it moves from considering difference to focusing on neutrality, from efforts that seek to counter subjugation to those that adopt a "color-blind" approach. The shifting approach already has reached laws regulating responses to the group that spurred massive civil rights reform: minority youth. The shift requires a different body of empirical evidence to address it and a new look at equality jurisprudence. This article notes the need to turn to the current understanding of prejudice and discrimination for guidance, and uses, as illustration, developmental science to shed light on the development, manifestation, and alleviation of invidious discrimination. Using that understanding, the analysis details how the legal system can benefit from that research and better address discrimination in light of dramatic changes in law. The article articulates the need to address discrimination by recognizing and enlisting the law's inculcative powers through multiple sites of inculcation, ranging from families, schools, health and justice systems to religious and community groups. The discussion concludes with brief suggestions for reform benefiting from understandings of prejudice and its expression. PMID:24826823

  4. Achieving Extreme Utilization of Excitons by an Efficient Sandwich-Type Emissive Layer Architecture for Reduced Efficiency Roll-Off and Improved Operational Stability in Organic Light-Emitting Diodes.

    PubMed

    Wu, Zhongbin; Sun, Ning; Zhu, Liping; Sun, Hengda; Wang, Jiaxiu; Yang, Dezhi; Qiao, Xianfeng; Chen, Jiangshan; Alshehri, Saad M; Ahamad, Tansir; Ma, Dongge

    2016-02-10

    It has been demonstrated that the efficiency roll-off is generally caused by the accumulation of excitons or charge carriers, which is intimately related to the emissive layer (EML) architecture in organic light-emitting diodes (OLEDs). In this article, an efficient sandwich-type EML structure with a mixed-host EML sandwiched between two single-host EMLs was designed to eliminate this accumulation, thus simultaneously achieving high efficiency, low efficiency roll-off and good operational stability in the resulting OLEDs. The devices show excellent electroluminescence performances, realizing a maximum external quantum efficiency (EQE) of 24.6% with a maximum power efficiency of 105.6 lm W(-1) and a maximum current efficiency of 93.5 cd A(-1). At the high brightness of 5,000 cd m(-2), they still remain as high as 23.3%, 71.1 lm W(-1), and 88.3 cd A(-1), respectively. And, the device lifetime is up to 2000 h at initial luminance of 1000 cd m(-2), which is significantly higher than that of compared devices with conventional EML structures. The improvement mechanism is systematically studied by the dependence of the exciton distribution in EML and the exciton quenching processes. It can be seen that the utilization of the efficient sandwich-type EML broadens the recombination zone width, thus greatly reducing the exciton quenching and increasing the probability of the exciton recombination. It is believed that the design concept provides a new avenue for us to achieve high-performance OLEDs. PMID:26828128

  5. The Ohio Vocational Education Achievement Test Program.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Trade and Industrial Education Instructional Materials Lab.

    The Ohio Vocational Achievement Tests are specially designed instruments for use by teachers, supervisors, and administrators to evaluate and diagnose vocational achievement for improving instruction in secondary vocational programs at the 11th and 12th grade levels. This guide explains the Ohio Vocational Achievement Tests and how they are used.…

  6. A Study of Effect of Dramatic Activities on Improving English Communicative Speaking Skill of Grade 11th Students

    ERIC Educational Resources Information Center

    Iamsaard, Prisana; Kerdpol, Sakon

    2015-01-01

    This paper aimed to reexamine the current EFL communicative speaking skill in high school level in Thailand due to the coming of the entry to ASEAN at the end of the year 2015. Thai students need to be well prepared for workforce in the future since English is used as the working language in ASEAN. The purposes of this paper were to study the…

  7. Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

    PubMed Central

    Fleetwood, Filippa; Klint, Susanne; Hanze, Martin; Gunneriusson, Elin; Frejd, Fredrik Y.; Ståhl, Stefan; Löfblom, John

    2014-01-01

    Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic targets. The aim of this work was to generate antagonistic VEGFR2-specific affinity proteins having adjustable pharmacokinetic properties allowing for either therapy or molecular imaging. Two antagonistic Affibody molecules that were cross-reactive for human and murine VEGFR2 were selected by phage and bacterial display. Surprisingly, although both binders independently blocked VEGF-A binding, competition assays revealed interaction with non-overlapping epitopes on the receptor. Biparatopic molecules, comprising the two Affibody domains, were hence engineered to potentially increase affinity even further through avidity. Moreover, an albumin-binding domain was included for half-life extension in future in vivo experiments. The best-performing of the biparatopic constructs demonstrated up to 180-fold slower dissociation than the monomers. The new Affibody constructs were also able to specifically target VEGFR2 on human cells, while simultaneously binding to albumin, as well as inhibit VEGF-induced signaling. In summary, we have generated small antagonistic biparatopic Affibody molecules with high affinity for VEGFR2, which have potential for both future therapeutic and diagnostic purposes in angiogenesis-related diseases. PMID:25515662

  8. Collaboration Takes Center Stage: Interactive Teaching through a Schoolwide Focus on the Performing Arts Leads to Dramatic Improvements in Learning

    ERIC Educational Resources Information Center

    Williamson, Jeff; Zimmerman, Diane

    2009-01-01

    In the Old Adobe Union School District in Petaluma, California, the school staff's goal is to assure that all teachers make the fundamental shift from teacher-centric to learner-centric thinking. For them, this is what distinguishes great teachers from good teachers. They believe this level of expertise takes years to develop and that schools play…

  9. Menu modeling with MyPyramid food patterns: Incremental dietary changes lead to dramatic improvements in diet quality of menus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The MyPyramid food guidance system provides recommended food intake patterns for members of each sex at various age and activity levels. These food intake patterns are based on recommendations of the Dietary Guidelines for Americans 2005. Actual consumption patterns of American adults compared to My...

  10. Comparing Science Achievement Constructs: Targeted and Achieved

    ERIC Educational Resources Information Center

    Ferrara, Steve; Duncan, Teresa

    2011-01-01

    This article illustrates how test specifications based solely on academic content standards, without attention to other cognitive skills and item response demands, can fall short of their targeted constructs. First, the authors inductively describe the science achievement construct represented by a statewide sixth-grade science proficiency test.…

  11. Health and Nutrition: Preconditions for Educational Achievement.

    ERIC Educational Resources Information Center

    Negussie, Birgit

    This paper discusses the importance of maternal and infant health for children's educational achievement. Education, health, and nutrition are so closely related that changes in one causes changes in the others. Improvement of maternal and preschooler health and nutrition is a precondition for improved educational achievement. Although parental…

  12. Varieties of Achievement Motivation.

    ERIC Educational Resources Information Center

    Kukla, Andre; Scher, Hal

    1986-01-01

    A recent article by Nicholls on achievement motivation is criticized on three points: (1) definitions of achievement motives are ambiguous; (2) behavioral consequences predicted do not follow from explicit theoretical assumptions; and (3) Nicholls's account of the relation between his theory and other achievement theories is factually incorrect.…

  13. Motivation and School Achievement.

    ERIC Educational Resources Information Center

    Maehr, Martin L.; Archer, Jennifer

    Addressing the question, "What can be done to promote school achievement?", this paper summarizes the literature on motivation relating to classroom achievement and school effectiveness. Particular attention is given to how values, ideology, and various cultural patterns impinge on classroom performance and serve to enhance motivation to achieve.…

  14. Mobility and Reading Achievement.

    ERIC Educational Resources Information Center

    Waters, Theresa Z.

    A study examined the effect of geographic mobility on elementary school students' achievement. Although such mobility, which requires students to make multiple moves among schools, can have a negative impact on academic achievement, the hypothesis for the study was that it was not a determining factor in reading achievement test scores. Subjects…

  15. PASS and Reading Achievement.

    ERIC Educational Resources Information Center

    Kirby, John R.

    Two studies examined the effectiveness of the PASS (Planning, Attention, Simultaneous, and Successive cognitive processes) theory of intelligence in predicting reading achievement scores of normally achieving children and distinguishing children with reading disabilities from normally achieving children. The first study dealt with predicting…

  16. Quick and continuous improvement through kaizen blitz.

    PubMed

    McNichols, T; Hassinger, R; Bapst, G W

    1999-05-01

    It is our objective to provide you with a step-by-step approach to conducting a kaizen blitz within two days and describe how to achieve dramatic performance improvement with employee buy-in through this process. Kaizen blitz has been used dozens of times by the authors, and in some instances the same area has been blitzed as many as four times, with significant improvements each and every time. Employees have even taken it on themselves to conduct informal blitzes as a continuing improvement effort after a formal blitz has been conducted in their area. Blitzes can succeed in a variety of environments. The morning after the employees of one company attended this presentation, they self initiated a mini-blitz and discovered opportunities for improvement that they enthusiastically presented to management. PMID:10387775

  17. Photographer : JPL Range : 1 million kilometers Voyager 2 completed a dramatic 10 hour time lapse

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Photographer : JPL Range : 1 million kilometers Voyager 2 completed a dramatic 10 hour time lapse photo sequence to monitor the active volcanos on Jupiter's moon Io following the spacecraft's closest approach to Jupiter. This picture is one of about 200 images that will be used to generate a time lapse motion picture to illustrate Io's volcanic activity. On the bright limb, two of the plumes (P-5 & P-6) discovered in March by Voyager 1 are again visible. The plumes are spewing materials to a height of about 100 kilometers.

  18. Dramatic effect of superfluidity on the collapse of 4He vapor bubbles

    NASA Astrophysics Data System (ADS)

    Qu, An; Trimeche, A.; Jacquier, Ph.; Grucker, J.

    2016-05-01

    The lifetime of cavitation bubbles produced by an acoustic wave focused in liquid helium-4 is investigated. This lifetime is found to be different by orders of magnitude depending on whether the liquid is superfluid or not. We show that if the liquid is in the superfluid state, the bubble lifetime is well explained by a purely mechanical model, corresponding to the so-called Rayleigh regime. In the normal state, the Rayleigh-Plesset regime applies, in which heat diffusion plays a crucial role and dramatically increases the bubble lifetime.

  19. Gorham-Stout Disease of the Skull Base With Hearing Loss: Dramatic Recovery and Antiangiogenic Therapy.

    PubMed

    Nozawa, Akifumi; Ozeki, Michio; Kuze, Bunya; Asano, Takahiko; Matsuoka, Kentaro; Fukao, Toshiyuki

    2016-05-01

    Gorham-Stout disease (GSD) is a rare disorder of unknown etiology. We present a 6-year-old male with GSD involving the skull base who presented with recurrent cerebrospinal fluid (CSF) rhinorrhea, severe hearing loss, and facial palsy secondary to cerebellar herniation into the internal auditory canal. After 2 months of treatment with pegylated interferon (IFN) α-2b (50 μg/week), his hearing recovered dramatically. Two years later, new bone formation appeared radiologically and IFN was switched to sirolimus. One year after the switch, CSF rhinorrhea disappeared. Antiangiogenic therapy might inhibit proliferation of vascular endothelial cells in osteolytic lesions and lead to new bone formation. PMID:26713883

  20. Dramatic reduction of crop-to-crop gene flow within a short distance from transgenic rice fields.

    PubMed

    Rong, Jun; Lu, Bao-Rong; Song, Zhiping; Su, Jun; Snow, Allison A; Zhang, Xinsheng; Sun, Shuguang; Chen, Rui; Wang, Feng

    2007-01-01

    Genetically modified (GM) rice with enhanced agronomic traits and pharmaceutical uses are ready for widespread adoption. Little is known about isolation requirements for achieving stringent transgene confinement in rice. To investigate the extent of pollen-mediated crop-to-crop transgene flow, we conducted a field experiment with four plot-size treatments of adjacent GM and nonGM rice (Oryza sativa) in China. Three insect-resistant GM rice (Bt/CpTI) and nonGM isogenic lines were used in the study. The hygromycin-resistance transgene (hpt) marker was used to screen seeds from the nonGM rice rows at different distance intervals from GM rice plots. Based on the examination of > 2.1 million germinated seeds, we found a dramatic reduction in transgene frequencies with increasing distance from the GM crop, ranging from c. 0.28% at 0.2 m to < 0.01% at 6.2 m. In addition, different plot size did not significantly affect the frequencies of gene flow. In conclusion, pollen-mediated crop-to-crop transgene flow in rice can be maintained at negligible levels with short spatial isolation. The model can also be applied to other crops with self- and wind-pollination. PMID:17204081