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Sample records for achieve highly conformal

  1. Effects of Achievement Motivation, Social Identity, and Peer Group Norms on Academic Conformity

    ERIC Educational Resources Information Center

    Masland, Lindsay C.; Lease, A. Michele

    2013-01-01

    This study investigated whether academic achievement motivation and social identity explain variation in children's conformity to positive academic behaviors (n = 455 children in grades three through five). Structural equation modeling suggested that academic value and peer group academic norms were positively related to academic conformity.…

  2. Achieving High Performance Perovskite Solar Cells

    NASA Astrophysics Data System (ADS)

    Yang, Yang

    2015-03-01

    Recently, metal halide perovskite based solar cell with the characteristics of rather low raw materials cost, great potential for simple process and scalable production, and extreme high power conversion efficiency (PCE), have been highlighted as one of the most competitive technologies for next generation thin film photovoltaic (PV). In UCLA, we have realized an efficient pathway to achieve high performance pervoskite solar cells, where the findings are beneficial to this unique materials/devices system. Our recent progress lies in perovskite film formation, defect passivation, transport materials design, interface engineering with respect to high performance solar cell, as well as the exploration of its applications beyond photovoltaics. These achievements include: 1) development of vapor assisted solution process (VASP) and moisture assisted solution process, which produces perovskite film with improved conformity, high crystallinity, reduced recombination rate, and the resulting high performance; 2) examination of the defects property of perovskite materials, and demonstration of a self-induced passivation approach to reduce carrier recombination; 3) interface engineering based on design of the carrier transport materials and the electrodes, in combination with high quality perovskite film, which delivers 15 ~ 20% PCEs; 4) a novel integration of bulk heterojunction to perovskite solar cell to achieve better light harvest; 5) fabrication of inverted solar cell device with high efficiency and flexibility and 6) exploration the application of perovskite materials to photodetector. Further development in film, device architecture, and interfaces will lead to continuous improved perovskite solar cells and other organic-inorganic hybrid optoelectronics.

  3. Spine stereotactic body radiation therapy plans: Achieving dose coverage, conformity, and dose falloff.

    PubMed

    Hong, Linda X; Shankar, Viswanathan; Shen, Jin; Kuo, Hsiang-Chi; Mynampati, Dinesh; Yaparpalvi, Ravindra; Goddard, Lee; Basavatia, Amar; Fox, Jana; Garg, Madhur; Kalnicki, Shalom; Tomé, Wolfgang A

    2015-01-01

    We report our experience of establishing planning objectives to achieve dose coverage, conformity, and dose falloff for spine stereotactic body radiation therapy (SBRT) plans. Patients with spine lesions were treated using SBRT in our institution since September 2009. Since September 2011, we established the following planning objectives for our SBRT spine plans in addition to the cord dose constraints: (1) dose coverage—prescription dose (PD) to cover at least 95% planning target volume (PTV) and 90% PD to cover at least 99% PTV; (2) conformity index (CI)—ratio of prescription isodose volume (PIV) to the PTV < 1.2; (3) dose falloff—ratio of 50% PIV to the PTV (R(50%)); (4) and maximum dose in percentage of PD at 2 cm from PTV in any direction (D(2cm)) to follow Radiation Therapy Oncology Group (RTOG) 0915. We have retrospectively reviewed 66 separate spine lesions treated between September 2009 and December 2012 (31 treated before September 2011 [group 1] and 35 treated after [group 2]). The χ(2) test was used to examine the difference in parameters between groups. The PTV V(100% PD) ≥ 95% objective was met in 29.0% of group 1 vs 91.4% of group 2 (p < 0.01) plans. The PTV V(90% PD) ≥ 99% objective was met in 38.7% of group 1 vs 88.6% of group 2 (p < 0.01) plans. Overall, 4 plans in group 1 had CI > 1.2 vs none in group 2 (p = 0.04). For D(2cm), 48.3% plans yielded a minor violation of the objectives and 16.1% a major violation for group 1, whereas 17.1% exhibited a minor violation and 2.9% a major violation for group 2 (p < 0.01). Spine SBRT plans can be improved on dose coverage, conformity, and dose falloff employing a combination of RTOG spine and lung SBRT protocol planning objectives.

  4. The Constraints of Poverty on High Achievement

    ERIC Educational Resources Information Center

    Burney, Virginia H.; Beilke, Jayne R.

    2008-01-01

    Research studies on school success often focus on the impact of discrete elements such as race, culture, ethnicity, gender, language, or school location on high achievement. The condition of poverty, however, may be the most important of all student differences in relation to high achievement; although not all schools have racial diversity, nearly…

  5. Self Regulated Learning of High Achievers

    ERIC Educational Resources Information Center

    Rathod, Ami

    2010-01-01

    The study was conducted on high achievers of Senior Secondary school. Main objectives were to identify the self regulated learners among the high achievers, to find out dominant components and characteristics operative in self regulated learners and to compare self regulated learning of learners with respect to their subject (science and non…

  6. Systemic Reform and Minority Student High Achievement.

    ERIC Educational Resources Information Center

    Treisman, Philip Uri; Surles, Stephanie A.

    The under-representation of African American and Hispanic American students among high achievers on standardized tests, honors graduates of most colleges, and practitioners of mathematics and science professions is well-documented. This paper explores the extent to which the current educational reform movement is achieving the goal of…

  7. Spine stereotactic body radiation therapy plans: Achieving dose coverage, conformity, and dose falloff

    SciTech Connect

    Hong, Linda X.; Shankar, Viswanathan; Shen, Jin; Kuo, Hsiang-Chi; Mynampati, Dinesh; Yaparpalvi, Ravindra; Goddard, Lee; Basavatia, Amar; Fox, Jana; Garg, Madhur; Kalnicki, Shalom; Tomé, Wolfgang A.

    2015-10-01

    We report our experience of establishing planning objectives to achieve dose coverage, conformity, and dose falloff for spine stereotactic body radiation therapy (SBRT) plans. Patients with spine lesions were treated using SBRT in our institution since September 2009. Since September 2011, we established the following planning objectives for our SBRT spine plans in addition to the cord dose constraints: (1) dose coverage—prescription dose (PD) to cover at least 95% planning target volume (PTV) and 90% PD to cover at least 99% PTV; (2) conformity index (CI)—ratio of prescription isodose volume (PIV) to the PTV < 1.2; (3) dose falloff—ratio of 50% PIV to the PTV (R{sub 50%}); (4) and maximum dose in percentage of PD at 2 cm from PTV in any direction (D{sub 2cm}) to follow Radiation Therapy Oncology Group (RTOG) 0915. We have retrospectively reviewed 66 separate spine lesions treated between September 2009 and December 2012 (31 treated before September 2011 [group 1] and 35 treated after [group 2]). The χ{sup 2} test was used to examine the difference in parameters between groups. The PTV V{sub 100%} {sub PD} ≥ 95% objective was met in 29.0% of group 1 vs 91.4% of group 2 (p < 0.01) plans. The PTV V{sub 90%} {sub PD} ≥ 99% objective was met in 38.7% of group 1 vs 88.6% of group 2 (p < 0.01) plans. Overall, 4 plans in group 1 had CI > 1.2 vs none in group 2 (p = 0.04). For D{sub 2cm}, 48.3% plans yielded a minor violation of the objectives and 16.1% a major violation for group 1, whereas 17.1% exhibited a minor violation and 2.9% a major violation for group 2 (p < 0.01). Spine SBRT plans can be improved on dose coverage, conformity, and dose falloff employing a combination of RTOG spine and lung SBRT protocol planning objectives.

  8. High-Quality Dataset of Protein-Bound Ligand Conformations and Its Application to Benchmarking Conformer Ensemble Generators.

    PubMed

    Friedrich, Nils-Ole; Meyder, Agnes; de Bruyn Kops, Christina; Sommer, Kai; Flachsenberg, Florian; Rarey, Matthias; Kirchmair, Johannes

    2017-02-16

    We developed a cheminformatics pipeline for the fully automated selection and extraction of high-quality protein-bound ligand conformations from X-ray structural data. The pipeline evaluates the validity and accuracy of the 3D structures of small molecules according to multiple criteria, including their fit to the electron density and their physicochemical and structural properties. Using this approach, we compiled two high-quality datasets from the Protein Data Bank (PDB): a comprehensive dataset and a diversified subset of 4626 and 2912 structures, respectively. The datasets were applied to benchmarking seven freely available conformer ensemble generators: Balloon (two different algorithms), the RDKit standard conformer ensemble generator, the Experimental-Torsion basic Knowledge Distance Geometry (ETKDG) algorithm, Confab, Frog2 and Multiconf-DOCK. Substantial differences in the performance of the individual algorithms were observed, with RDKit and ETKDG generally achieving a favorable balance of accuracy, ensemble size and runtime. The Platinum datasets are available for download from http://www.zbh.uni-hamburg.de/platinum_dataset .

  9. Student Perceptions of High-Achieving Classmates

    ERIC Educational Resources Information Center

    Händel, Marion; Vialle, Wilma; Ziegler, Albert

    2013-01-01

    The reported study investigated students' perceptions of their high-performing classmates in terms of intelligence, social skills, and conscientiousness in different school subjects. The school subjects for study were examined with regard to cognitive, physical, and gender-specific issues. The results show that high academic achievements in…

  10. High Stakes Testing and Student Achievement.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    The effects of high stakes testing may be critical in the lives of public school students and may have many consequences for schools and teachers. There are no easy answers in measuring student achievement and in holding teachers accountable for learner progress. High stakes testing also involves responsibilities on the part of the principal who…

  11. Curved and conformal high-pressure vessel

    SciTech Connect

    Croteau, Paul F.; Kuczek, Andrzej E.; Zhao, Wenping

    2016-10-25

    A high-pressure vessel is provided. The high-pressure vessel may comprise a first chamber defined at least partially by a first wall, and a second chamber defined at least partially by the first wall. The first chamber and the second chamber may form a curved contour of the high-pressure vessel. A modular tank assembly is also provided, and may comprise a first mid tube having a convex geometry. The first mid tube may be defined by a first inner wall, a curved wall extending from the first inner wall, and a second inner wall extending from the curved wall. The first inner wall may be disposed at an angle relative to the second inner wall. The first mid tube may further be defined by a short curved wall opposite the curved wall and extending from the second inner wall to the first inner wall.

  12. ACHIEVEMENT MOTIVATION, AFFILIATION MOTIVATION, AND TASK DIFFICULTY AS DETERMINANTS OF SOCIAL CONFORMITY

    DTIC Science & Technology

    subjected to contrived group pressures toward erroneous perceptual judgments. An analysis of variance of frequencies of conforming behavior revealed (a... conformity to group pressures disappear when predispositional motivational factors are controlled. (Author)...Extending from the differentiation of normative and informational processes of social influence an investigation of interactions between two

  13. High Achievers: 23rd Annual Survey. Attitudes and Opinions from the Nation's High Achieving Teens.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Northbrook, IL.

    This report presents data from an annual survey of high school student leaders and high achievers. It is noted that of the nearly 700,000 high achievers featured in this edition, 5,000 students were sent the survey and 2,092 questionnaires were completed. Subjects were high school juniors and seniors selected for recognition by their principals or…

  14. Reliability achievement in high technology space systems

    NASA Technical Reports Server (NTRS)

    Lindstrom, D. L.

    1981-01-01

    The production of failure-free hardware is discussed. The elements required to achieve such hardware are: technical expertise to design, analyze, and fully understand the design; use of high reliability parts and materials control in the manufacturing process; and testing to understand the system and weed out defects. The durability of the Hughes family of satellites is highlighted.

  15. Catalytic performance and thermostability of chloroperoxidase in reverse micelle: achievement of a catalytically favorable enzyme conformation.

    PubMed

    Wang, Yali; Wu, Jinyue; Ru, Xuejiao; Jiang, Yucheng; Hu, Mancheng; Li, Shuni; Zhai, Quanguo

    2011-06-01

    The catalytic performance of chloroperoxidase (CPO) in peroxidation of 2, 2'-azinobis-(-3 ethylbenzothiazoline-6-sulfononic acid) diammonium salt (ABTS) and oxidation of indole in a reverse micelle composed of surfactant-water-isooctane-pentanol was investigated and optimized in this work. Some positive results were obtained as follows: the peroxidation activity of CPO was enhanced 248% and 263%, while oxidation activity was enhanced 215% and 222% in cetyltrimethylammonium bromide (CTABr) reverse micelle medium and dodecyltrimethylammonium bromide (DTABr) medium, respectively. Thermostability was also greatly improved in reverse micelle: at 40 °C, CPO essentially lost all its activity after 5 h incubation, while 58-76% catalytic activity was retained for both reactions in the two reverse micelle media. At 50 °C, about 44-75% catalytic activity remained for both reactions in reverse micelle after 2 h compared with no observed activity in pure buffer under the same conditions. The enhancement of CPO activity was dependent mainly on the surfactant concentration and structure, organic solvent ratio (V(pentanol)/V(isooctane)), and water content in the reverse micelle. The obtained kinetic parameters showed that the catalytic turnover frequency (k(cat)) was increased in reverse micelle. Moreover, the lower K(m) and higher k(cat)/K(m) demonstrated that both the affinity and specificity of CPO to substrates were improved in reverse micelle media. Fluorescence, circular dichroism (CD) and UV-vis spectra assays indicated that a catalytically favorable conformation of enzyme was achieved in reverse micelle, including the strengthening of the protein α-helix structure, and greater exposure of the heme prosthetic group for easy access of the substrate in bulk solution. These results are promising in view of the industrial applications of this versatile biological catalyst.

  16. Early predictors of high school mathematics achievement.

    PubMed

    Siegler, Robert S; Duncan, Greg J; Davis-Kean, Pamela E; Duckworth, Kathryn; Claessens, Amy; Engel, Mimi; Susperreguy, Maria Ines; Chen, Meichu

    2012-07-01

    Identifying the types of mathematics content knowledge that are most predictive of students' long-term learning is essential for improving both theories of mathematical development and mathematics education. To identify these types of knowledge, we examined long-term predictors of high school students' knowledge of algebra and overall mathematics achievement. Analyses of large, nationally representative, longitudinal data sets from the United States and the United Kingdom revealed that elementary school students' knowledge of fractions and of division uniquely predicts those students' knowledge of algebra and overall mathematics achievement in high school, 5 or 6 years later, even after statistically controlling for other types of mathematical knowledge, general intellectual ability, working memory, and family income and education. Implications of these findings for understanding and improving mathematics learning are discussed.

  17. Native proteins trap high-energy transit conformations.

    PubMed

    Brereton, Andrew E; Karplus, P Andrew

    2015-10-01

    During protein folding and as part of some conformational changes that regulate protein function, the polypeptide chain must traverse high-energy barriers that separate the commonly adopted low-energy conformations. How distortions in peptide geometry allow these barrier-crossing transitions is a fundamental open question. One such important transition involves the movement of a non-glycine residue between the left side of the Ramachandran plot (that is, ϕ < 0°) and the right side (that is, ϕ > 0°). We report that high-energy conformations with ϕ ~ 0°, normally expected to occur only as fleeting transition states, are stably trapped in certain highly resolved native protein structures and that an analysis of these residues provides a detailed, experimentally derived map of the bond angle distortions taking place along the transition path. This unanticipated information lays to rest any uncertainty about whether such transitions are possible and how they occur, and in doing so lays a firm foundation for theoretical studies to better understand the transitions between basins that have been little studied but are integrally involved in protein folding and function. Also, the context of one such residue shows that even a designed highly stable protein can harbor substantial unfavorable interactions.

  18. Attitudes and Opinions from the Nation's High Achieving Teens. 18th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Educational Communications, Inc., Lake Forest, IL.

    This document contains factsheets and news releases which cite findings from a national survey of 1,985 high achieving high school students. Factsheets describe the Who's Who Among American High School Students recognition and service program for high school students and explain the Who's Who survey. A summary report of this eighteenth annual…

  19. Method for producing highly conformal transparent conducting oxides

    SciTech Connect

    Elam, Jeffrey W.; Mane, Anil U.

    2016-07-26

    A method for forming a transparent conducting oxide product layer. The method includes use of precursors, such as tetrakis-(dimethylamino) tin and trimethyl indium, and selected use of dopants, such as SnO and ZnO for obtaining desired optical, electrical and structural properties for a highly conformal layer coating on a substrate. Ozone was also input as a reactive gas which enabled rapid production of the desired product layer.

  20. 22nd Annual Survey of High Achievers: Attitudes and Opinions from the Nation's High Achieving Teens.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Northbrook, IL.

    This study surveyed high school students (N=1,879) who were student leaders or high achievers in the spring of 1991 for the purpose of determining their attitudes. Students were members of the junior or senior high school class during the 1990-91 academic year and were selected for recognition by their principals or guidance counselors, other…

  1. Conformal BaTiO3 Films with High Piezoelectric Coupling through an Optimized Hydrothermal Synthesis.

    PubMed

    Zhou, Zhi; Bowland, Christopher C; Patterson, Brendan A; Malakooti, Mohammad H; Sodano, Henry A

    2016-08-24

    Two-dimensional (2D) ferroelectric films have vast applications due to their dielectric, ferroelectric, and piezoelectric properties that meet the requirements of sensors, nonvolatile ferroelectric random access memory (NVFeRAM) devices, and micro-electromechanical systems (MEMS). However, the small surface area of these 2D ferroelectric films has limited their ability to achieve higher memory storage density in NVFeRAM devices and more sensitive sensors and transducer. Thus, conformally deposited ferroelectric films have been actively studied for these applications in order to create three-dimensional (3D) structures, which lead to a larger surface area. Most of the current methods developed for the conformal deposition of ferroelectric films, such as metal-organic chemical vapor deposition (MOCVD) and plasma-enhanced vapor deposition (PECVD), are limited by high temperatures and unstable and toxic organic precursors. In this paper, an innovative fabrication method for barium titanate (BaTiO3) textured films with 3D architectures is introduced to alleviate these issues. This fabrication method is based on converting conformally grown rutile TiO2 nanowire arrays into BaTiO3 textured films using a simple two-step hydrothermal process which allows for thickness-controlled growth of conformal films on patterned silicon wafers coated with fluorine-doped tin oxide (FTO). Moreover, the processing parameters have been optimized to achieve a high piezoelectric coupling coefficient of 100 pm/V. This high piezoelectric response along with high relative dielectric constant (εr = 1600) of the conformally grown textured BaTiO3 films demonstrates their potential application in sensors, NVFeRAM, and MEMS.

  2. Attitudes and Opinions from the Nation's High Achieving Teens: 26th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    A national survey of 3,351 high achieving high school students (junior and senior level) was conducted. All students had A or B averages. Topics covered include lifestyles, political beliefs, violence and entertainment, education, cheating, school violence, sexual violence and date rape, peer pressure, popularity, suicide, drugs and alcohol,…

  3. Attitudes and Opinions from the Nation's High Achieving Teens. 24th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This survey represents information compiled by the largest national survey of adolescent leaders and high achievers. Of the 5,000 students selected demographically from "Who's Who Among American High School Students," 1,957 responded. All students surveyed had "A" or "B" averages, and 98% planned on attending college. Questions were asked about…

  4. Effects of high external electric fields on protein conformation

    NASA Astrophysics Data System (ADS)

    Pompa, Pier Paolo; Bramanti, Alessandro; Maruccio, Giuseppe; del Mercato, Loretta Laureana; Chiuri, Rocco; Cingolani, Roberto; Rinaldi, Ross

    2005-06-01

    Resistance of biomolecules to high electric fields is a main concern for nanobioelectronics/nanobiosensing applications, and it is also a relevant issue from a fundamental perspective, to understand the dielectric properties and structural dynamics of proteins. In nanoscale devices, biomolecules may experience electric fields as high as 107 V/m in order to elicit charge transport/transfer. Understanding the effects of such fields on their structural integrity is thus crucial to assess the reliability of biomolecular devices. In this study, we show experimental evidence for the retention of native-like fold pattern by proteins embedded in high electric fields. We have tested the metalloprotein azurin, deposited onto SiO2 substrates in air with proper electrode configuration, by applying high static electric fields (up to 106-107 V/m). The effects on the conformational properties of protein molecules have been determined by means of intrinsic fluorescence measurements. Experimental results indicate that no significant field-induced conformational alteration occurs. This behavior is also discussed and supported by theoretical predictions of the intrinsic intra-protein electric fields. As the general features of such inner fields are not peculiar of azurin, the conclusions presented here should have general validity.

  5. Pseudoelastic behaviour of a natural material is achieved via reversible changes in protein backbone conformation

    PubMed Central

    Harrington, Matthew J.; Wasko, S. Scott; Masic, Admir; Fischer, F. Dieter; Gupta, Himadri S.; Fratzl, Peter

    2012-01-01

    The egg capsules of marine prosobranch gastropods, commonly know as whelks, function as a protective encapsulant for whelk embryos in wave-swept marine environments. The proteinaceous sheets comprising the wall of whelk egg capsules (WEC) exhibit long-range reversible extensibility with a hysteresis of up to 50 per cent, previously suggested to result from reversible changes in the structure of the constituent protein building blocks. Here, we further investigate the structural changes of the WEC biopolymer at various hierarchical levels using several different time-resolved in situ approaches. We find strong evidence in these biological polymers for a strain-induced reversible transition from an ordered conformational phase to a largely disordered one that leads to the characteristic reversible hysteretic behaviour, which is reminiscent of the pseudoelastic behaviour in some metallic alloys. On the basis of these results, we generate a simple numerical model incorporating a worm-like chain equation to explain the phase transition behaviour of the WEC at the molecular level. PMID:22696489

  6. High Involvement Mothers of High Achieving Children: Potential Theoretical Explanations

    ERIC Educational Resources Information Center

    Hunsaker, Scott L.

    2013-01-01

    In American society, parents who have high aspirations for the achievements of their children are often viewed by others in a negative light. Various pejoratives such as "pushy parent," "helicopter parent," "stage mother," and "soccer mom" are used in the common vernacular to describe these parents. Multiple…

  7. Does High School Homework Increase Academic Achievement?

    ERIC Educational Resources Information Center

    Kalenkoski, Charlene Marie; Pabilonia, Sabrina Wulff

    2017-01-01

    Although previous research has shown that homework improves students' academic achievement, the majority of these studies use data on students' homework time from retrospective questionnaires, which may be less accurate than time-diary data. We use data from the combined Child Development Supplement (CDS) and the Transition to Adulthood Survey…

  8. Factors Implicated in High Mathematics Achievement

    ERIC Educational Resources Information Center

    Forgasz, Helen J.; Hill, Janelle C.

    2013-01-01

    The most recent Program for International Student Assessment (PISA) (2009) mathematical literacy results provide evidence that in Western English-speaking countries, including Australia, the gender gap in achievement appears to be widening in favour of males. In the study reported in this article, the aim was to explore the effects of gender,…

  9. High Ability Readers and the Achievement Gap

    ERIC Educational Resources Information Center

    Hunsaker, Scott L.; Parke, Cynthia J.; Bramble, Joan G.

    2004-01-01

    To close the achievement gap, the "No Child Left Behind" law calls for all students to make appropriate yearly progress. This presumably means that progress is being made by capable readers at the same time progress is being made by struggling readers. However, there appear to be unintended effects of "No Child Left Behind"…

  10. High-Achieving Students in the Era of NCLB

    ERIC Educational Resources Information Center

    Loveless, Tom; Parkas, Steve; Duffett, Ann

    2008-01-01

    This report contains two separate studies examining the status of high-achieving students in the No Child Left Behind (NCLB) era. Part I, An Analysis of NAEP Data, authored by Brookings Institution scholar Tom Loveless, examines achievement trends for high-achieving students (defined, like low-achieving students, by their performance on the…

  11. Improving Student Achievement: A Study of High-Poverty Schools with Higher Student Achievement Outcomes

    ERIC Educational Resources Information Center

    Butz, Stephen D.

    2012-01-01

    This research examined the education system at high-poverty schools that had significantly higher student achievement levels as compared to similar schools with lower student achievement levels. A multischool qualitative case study was conducted of the educational systems where there was a significant difference in the scores achieved on the…

  12. Achieving strategic surety for high consequence software

    SciTech Connect

    Pollock, G.M.

    1996-09-01

    A strategic surety roadmap for high consequence software systems under the High Integrity Software (HIS) Program at Sandia National Laboratories guides research in identifying methodologies to improve software surety. Selected research tracks within this roadmap are identified and described detailing current technology and outlining advancements to be pursued over the coming decade to reach HIS goals. The tracks discussed herein focus on Correctness by Design, and System Immunology{trademark}. Specific projects are discussed with greater detail given on projects involving Correct Specification via Visualization, Synthesis, & Analysis; Visualization of Abstract Objects; and Correct Implementation of Components.

  13. Achieving High-Temperature Ferromagnetic Topological Insulator

    NASA Astrophysics Data System (ADS)

    Katmis, Ferhat

    Topological insulators (TIs) are insulating materials that display conducting surface states protected by time-reversal symmetry, wherein electron spins are locked to their momentum. This unique property opens new opportunities for creating next-generation electronic and spintronic devices, including TI-based quantum computation. Introducing ferromagnetic order into a TI system without compromising its distinctive quantum coherent features could lead to a realization of several predicted novel physical phenomena. In particular, achieving robust long-range magnetic order at the TI surface at specific locations without introducing spin scattering centers could open up new possibilities for devices. Here, we demonstrate topologically enhanced interface magnetism by coupling a ferromagnetic insulator (FMI) to a TI (Bi2Se3); this interfacial ferromagnetism persists up to room temperature, even though the FMI (EuS) is known to order ferromagnetically only at low temperatures (<17 K). The induced magnetism at the interface resulting from the large spin-orbit interaction and spin-momentum locking feature of the TI surface is found to greatly enhance the magnetic ordering (Curie) temperature of the TI/FMI bilayer system. Due to the short range nature of the ferromagnetic exchange interaction, the time-reversal symmetry is broken only near the surface of a TI, while leaving its bulk states unaffected. The topological magneto-electric response originating in such an engineered TI could allow for an efficient manipulation of the magnetization dynamics by an electric field, providing an energy efficient topological control mechanism for future spin-based technologies. Work supported by MIT MRSEC through the MRSEC Program of NSF under award number DMR-0819762, NSF Grant DMR-1207469, the ONR Grant N00014-13-1-0301, and the STC Center for Integrated Quantum Materials under NSF grant DMR-1231319.

  14. Norview High School: Leadership Fosters Achievment

    ERIC Educational Resources Information Center

    Principal Leadership, 2013

    2013-01-01

    Often little unsaid things demonstrate what is truly important in a school. When teachers have common planning time and all of the department chairs share a single space as they do at Norview High School in Norfolk, VA, the unmistakable message is that instructional collaboration and leadership are expected and valued. Norview, an urban,…

  15. Self-Concept and Achievement Motivation of High School Students

    ERIC Educational Resources Information Center

    Lawrence, A. S. Arul; Vimala, A.

    2013-01-01

    The present study "Self-concept and Achievement Motivation of High School Students" was investigated to find the relationship between Self-concept and Achievement Motivation of High School Students. Data for the study were collected using Self-concept Questionnaire developed by Raj Kumar Saraswath (1984) and Achievement Motive Test (ACMT)…

  16. Gun requirements to achieve high field spheromaks

    SciTech Connect

    Fowler, T K

    1999-03-04

    It is shown that a gun similar to that in the SSPX could demonstrate the high fields required for Pulsed Spheromak reactors merely by prolonging the pulse. Important considerations are choosing the voltage to exceed ohmic losses; designing the gun to avoid wasteful short-circuiting of current within the gun; and the injection efficiency factor, f, determined by the ''sag'' in the profile of {lambda} = {mu}{sub o}j/B. Typically f = 0.75 in experiments, giving an overall efficiency > 50 % if short-circuiting is avoided. Theoretical transport models agree qualitatively with the need for a finite gradient in h to pump in helicity by current-driven tearing modes and suggest that pressure-driven resistive modes would not compete with current-driven modes during a buildup to ohmic ignition.

  17. Scientific Temper among Academically High and Low Achieving Adolescent Girls

    ERIC Educational Resources Information Center

    Kour, Sunmeet

    2015-01-01

    The present study was undertaken to compare the scientific temper of high and low achieving adolescent girl students. Random sampling technique was used to draw the sample from various high schools of District Srinagar. The sample for the present study consisted of 120 school going adolescent girls (60 high and 60 low achievers). Data was…

  18. Exploration of conformational spaces of high-mannose-type oligosaccharides by an NMR-validated simulation.

    PubMed

    Yamaguchi, Takumi; Sakae, Yoshitake; Zhang, Ying; Yamamoto, Sayoko; Okamoto, Yuko; Kato, Koichi

    2014-10-06

    Exploration of the conformational spaces of flexible biomacromolecules is essential for quantitatively understanding the energetics of their molecular recognition processes. We employed stable isotope- and lanthanide-assisted NMR approaches in conjunction with replica-exchange molecular dynamics (REMD) simulations to obtain atomic descriptions of the conformational dynamics of high-mannose-type oligosaccharides, which harbor intracellular glycoprotein-fate determinants in their triantennary structures. The experimentally validated REMD simulation provided quantitative views of the dynamic conformational ensembles of the complicated, branched oligosaccharides, and indicated significant expansion of the conformational space upon removal of a terminal mannose residue during the functional glycan-processing pathway.

  19. Conformal Invariance in Driven Diffusive Systems at High Currents

    NASA Astrophysics Data System (ADS)

    Karevski, D.; Schütz, G. M.

    2017-01-01

    We consider space-time correlations in driven diffusive systems which undergo a fluctuation into a regime with an atypically large current or dynamical activity. For a single conserved mass we show that the spatiotemporal density correlations in one space dimension are fully determined by conformal field theory with central charge c =1 , corresponding to a ballistic universality class with dynamical exponent z =1 . The full phase diagram for general atypical behavior exhibits the conformally invariant regime and, for atypically low current or activity, a region of phase separation. The phase transition line between these two regimes corresponds to typical behavior and the dynamics belongs to the Kardar-Parisi-Zhang universality class with dynamical exponent z =3 /2 , except for a diffusive point with z =2 . The exact universal dynamical structure function is obtained in explicit form from the one-dimensional asymmetric simple exclusion process with periodic and open boundaries in the limit of maximal current.

  20. The "Renaissance Child": High Achievement and Gender in Late Modernity

    ERIC Educational Resources Information Center

    Skelton, Christine; Francis, Becky

    2012-01-01

    This paper draws on the concept of the "Renaissance Child" to illustrate the ways in which gender influences the opportunities and possibilities of high-achieving pupils. Using data from a study of 12-13-year high-achieving boys and girls based in schools in England, the paper considers the ways in which a group of popular boys was able…

  1. Dynamic Aberration Correction for Conformal Window of High-Speed Aircraft Using Optimized Model-Based Wavefront Sensorless Adaptive Optics.

    PubMed

    Dong, Bing; Li, Yan; Han, Xin-Li; Hu, Bin

    2016-09-02

    For high-speed aircraft, a conformal window is used to optimize the aerodynamic performance. However, the local shape of the conformal window leads to large amounts of dynamic aberrations varying with look angle. In this paper, deformable mirror (DM) and model-based wavefront sensorless adaptive optics (WSLAO) are used for dynamic aberration correction of an infrared remote sensor equipped with a conformal window and scanning mirror. In model-based WSLAO, aberration is captured using Lukosz mode, and we use the low spatial frequency content of the image spectral density as the metric function. Simulations show that aberrations induced by the conformal window are dominated by some low-order Lukosz modes. To optimize the dynamic correction, we can only correct dominant Lukosz modes and the image size can be minimized to reduce the time required to compute the metric function. In our experiment, a 37-channel DM is used to mimic the dynamic aberration of conformal window with scanning rate of 10 degrees per second. A 52-channel DM is used for correction. For a 128 × 128 image, the mean value of image sharpness during dynamic correction is 1.436 × 10(-5) in optimized correction and is 1.427 × 10(-5) in un-optimized correction. We also demonstrated that model-based WSLAO can achieve convergence two times faster than traditional stochastic parallel gradient descent (SPGD) method.

  2. Dynamic Aberration Correction for Conformal Window of High-Speed Aircraft Using Optimized Model-Based Wavefront Sensorless Adaptive Optics

    PubMed Central

    Dong, Bing; Li, Yan; Han, Xin-li; Hu, Bin

    2016-01-01

    For high-speed aircraft, a conformal window is used to optimize the aerodynamic performance. However, the local shape of the conformal window leads to large amounts of dynamic aberrations varying with look angle. In this paper, deformable mirror (DM) and model-based wavefront sensorless adaptive optics (WSLAO) are used for dynamic aberration correction of an infrared remote sensor equipped with a conformal window and scanning mirror. In model-based WSLAO, aberration is captured using Lukosz mode, and we use the low spatial frequency content of the image spectral density as the metric function. Simulations show that aberrations induced by the conformal window are dominated by some low-order Lukosz modes. To optimize the dynamic correction, we can only correct dominant Lukosz modes and the image size can be minimized to reduce the time required to compute the metric function. In our experiment, a 37-channel DM is used to mimic the dynamic aberration of conformal window with scanning rate of 10 degrees per second. A 52-channel DM is used for correction. For a 128 × 128 image, the mean value of image sharpness during dynamic correction is 1.436 × 10−5 in optimized correction and is 1.427 × 10−5 in un-optimized correction. We also demonstrated that model-based WSLAO can achieve convergence two times faster than traditional stochastic parallel gradient descent (SPGD) method. PMID:27598161

  3. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes

    NASA Astrophysics Data System (ADS)

    Baird, Nathan J.; Inglese, James; Ferré-D'Amaré, Adrian R.

    2015-12-01

    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. The method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. This demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  4. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes

    SciTech Connect

    Baird, Nathan J.; Inglese, James; Ferré-D’Amaré, Adrian R.

    2015-12-07

    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. This method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. Our research demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  5. High-fidelity conformation of graphene to SiO2 topographic features.

    PubMed

    Cullen, W G; Yamamoto, M; Burson, K M; Chen, J H; Jang, C; Li, L; Fuhrer, M S; Williams, E D

    2010-11-19

    High-resolution noncontact atomic force microscopy of SiO2 reveals previously unresolved roughness at the few-nm length scale, and scanning tunneling microscopy of graphene on SiO2 shows graphene to be slightly smoother than the supporting SiO2 substrate. A quantitative energetic analysis explains the observed roughness of graphene on SiO2 as extrinsic, and a natural result of highly conformal adhesion. Graphene conforms to the substrate down to the smallest features with nearly 99% fidelity, indicating conformal adhesion can be highly effective for strain engineering of graphene.

  6. Conformable pressure vessel for high pressure gas storage

    DOEpatents

    Simmons, Kevin L.; Johnson, Kenneth I.; Lavender, Curt A.; Newhouse, Norman L.; Yeggy, Brian C.

    2016-01-12

    A non-cylindrical pressure vessel storage tank is disclosed. The storage tank includes an internal structure. The internal structure is coupled to at least one wall of the storage tank. The internal structure shapes and internally supports the storage tank. The pressure vessel storage tank has a conformability of about 0.8 to about 1.0. The internal structure can be, but is not limited to, a Schwarz-P structure, an egg-crate shaped structure, or carbon fiber ligament structure.

  7. Test-Taking Strategies of High and Low Mathematics Achievers

    ERIC Educational Resources Information Center

    Hong, Eunsook; Sas, Maggie; Sas, John C.

    2006-01-01

    The authors explored test-preparation and test-taking strategies that high school students used in algebra tests. From a pool of high school students (N = 156), 61 students participated in interviews, and of those interviewed, 26 represented those who were high achieving as well as highly interested in mathematics (n = 15) vs. those who were low…

  8. Some Correlates of High School Foreign Language Achievement.

    ERIC Educational Resources Information Center

    Beanblossom, Gary F.

    This paper investigates the influences of traditional kinds of verbal and quantitative achievement and aptitude variables on high school foreign language achievement, as measured by Modern Language Association and University of Washington tests of language skills administered to entering college students. The report focuses on: (1) the sample and…

  9. Trickle-Down Preferences: Preferential Conformity to High Status Peers in Fashion Choices.

    PubMed

    Galak, Jeff; Gray, Kurt; Elbert, Igor; Strohminger, Nina

    2016-01-01

    How much do our choices represent stable inner preferences versus social conformity? We examine conformity and consistency in sartorial choices surrounding a common life event of new norm exposure: relocation. A large-scale dataset of individual purchases of women's shoes (16,236 transactions) across five years and 2,007 women reveals a balance of conformity and consistency, moderated by changes in location socioeconomic status. Women conform to new local norms (i.e., average heel size) when moving to relatively higher status locations, but mostly ignore new local norms when moving to relatively lower status locations. In short, at periods of transition, it is the fashion norms of the rich that trickle down to consumers. These analyses provide the first naturalistic large-scale demonstration of the tension between psychological conformity and consistency, with real decisions in a highly visible context.

  10. Trickle-Down Preferences: Preferential Conformity to High Status Peers in Fashion Choices

    PubMed Central

    Galak, Jeff; Gray, Kurt; Elbert, Igor; Strohminger, Nina

    2016-01-01

    How much do our choices represent stable inner preferences versus social conformity? We examine conformity and consistency in sartorial choices surrounding a common life event of new norm exposure: relocation. A large-scale dataset of individual purchases of women’s shoes (16,236 transactions) across five years and 2,007 women reveals a balance of conformity and consistency, moderated by changes in location socioeconomic status. Women conform to new local norms (i.e., average heel size) when moving to relatively higher status locations, but mostly ignore new local norms when moving to relatively lower status locations. In short, at periods of transition, it is the fashion norms of the rich that trickle down to consumers. These analyses provide the first naturalistic large-scale demonstration of the tension between psychological conformity and consistency, with real decisions in a highly visible context. PMID:27144595

  11. Attitudes and Opinions from the Nation's High Achieving Teens: 29th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report presents the 1998 statistical findings of the annual survey to determine the attitudes of national high school student leaders. Questionnaires were completed by 3,123 high school juniors and seniors, all of whom were selected for recognition in "Who's Who among American High School Students." In addition to demographic…

  12. Conformable actively multiplexed high-density surface electrode array for brain interfacing

    DOEpatents

    Rogers, John; Kim, Dae-Hyeong; Litt, Brian; Viventi, Jonathan

    2015-01-13

    Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.

  13. Peak deconvolution in high-field asymmetric waveform ion mobility spectrometry (FAIMS) to characterize macromolecular conformations

    NASA Astrophysics Data System (ADS)

    Robinson, Errol W.; Sellon, Rachel E.; Williams, Evan R.

    2007-01-01

    Protonated poly(ethylene glycol), produced by electrospray ionization (ESI), with molecular weights ranging from 0.3 to 5 kDa and charge states from 1+ to 7+ were characterized using high-field asymmetric waveform ion mobility spectrometry (FAIMS). Results for all but some of the 3+ and 4+ charge states are consistent with a single gas-phase conformer or family of unresolved conformers for each of these charge states. The FAIMS compensation voltage scans resulted in peaks that could be accurately fit with a single Gaussian for each peak. The peak widths increase linearly with compensation voltage for maximum ion transmission but do not depend on m/z or molecular weight. Fitting parameters obtained from the poly(ethylene glycol) data were used to analyze conformations of oxidized and reduced lysozyme formed from different solutions. For oxidized lysozyme formed from a buffered aqueous solution, a single conformer (or group of unresolved conformers) was observed for the 7+ and 8+ charge states. Two conformers were observed for the 9+ and 10+ charge states formed from more denaturing solutions. Data for the fully reduced form indicate the existence of up to three different conformers for each charge state produced directly by ESI and a general progression from a more extended to a more folded structure with decreasing charge state. These results are consistent with those obtained previously by proton-transfer reactivity and drift tube ion mobility experiments, although more conformers were identified for the fully reduced form of lysozyme using FAIMS.

  14. Achievement Motivation Training for Potential High School Dropouts. Achievement Motivation Development Project Working Paper Number 4.

    ERIC Educational Resources Information Center

    McClelland, David C.

    This pilot project sought to determine if instruction in achievement motivation would help potential dropouts to complete their schooling. Subjects were tenth grade students in a suburban Boston high school. A one-week residential course during winter and spring vacations was taken by one group of six boys and a second group of four. Equated…

  15. Attitudes and Opinions from the Nation's High Achieving Teens: 28th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report details the 28th annual study to examine the attitudes of student leaders in U.S. high schools. Participating in the survey were 3,210 adolescents, primarily 16- and 17-year-olds, who had been featured in the 1997 edition of "Who's Who Among American High School Students." The report presents demographic information on the…

  16. Attitudes and Opinions from the Nation's High Achieving Teens: 27th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This report details the 27th annual study to examine the attitudes of student leaders in U.S. high schools. Participating in the survey were 3,370 adolescents, primarily 16- and 17-year-olds, who had been featured in the 1996 edition of "Who's Who Among American High School Students." The report presents demographic information on the survey…

  17. NIR Laser Radiation Induced Conformational Changes and Tunneling Lifetimes of High-Energy Conformers of Amino Acids in Low-Temperature Matrices

    NASA Astrophysics Data System (ADS)

    Bazso, Gabor; Najbauer, Eszter E.; Magyarfalvi, Gabor; Tarczay, Gyorgy

    2013-06-01

    We review our recent results on combined matrix isolation FT-IR and NIR laser irradiation studies on glycine alanine, and cysteine. The OH and the NH stretching overtones of the low-energy conformers of these amino acids deposited in Ar, Kr, Xe, and N_{2} matrices were irradiated. At the expense of the irradiated conformer, other conformers were enriched and new, high-energy, formerly unobserved conformers were formed in the matrices. This enabled the separation and unambiguous assignment of the vibrational transitions of the different conformers. The main conversion paths and their efficiencies are described qualitatively showing that there are significant differences in different matrices. It was shown that the high-energy conformer decays in the matrix by H-atom tunneling. The lifetimes of the high-energy conformers in different matrices were measured. Based on our results we conclude that some theoretically predicted low-energy conformers of amino acids are likely even absent in low-energy matrices due to fast H-atom tunneling. G. Bazso, G. Magyarfalvi, G. Tarczay J. Mol. Struct. 1025 (Light-Induced Processes in Cryogenic Matrices Special Issue) 33-42 (2012). G. Bazso, G. Magyarfalvi, G. Tarczay J. Phys. Chem. A 116 (43) 10539-10547 (2012). G. Bazso, E. E. Najbauer, G. Magyarfalvi, G. Tarczay J. Phys. Chem. A in press, DOI: 10.1021/jp400196b. E. E. Najbauer, G. Bazso, G. Magyarfalvi, G. Tarczay in preparation.

  18. Attitudes and Opinions from the Nation's High Achieving Teens. 25th Annual Survey of High Achievers.

    ERIC Educational Resources Information Center

    Who's Who among American High School Students, Lake Forest, IL.

    This survey was conducted during the spring of 1994 for the purpose of determining the attitudes of student leaders in the nation's high schools. Eight thousand surveys were sent out to students, of which 3177 were returned. All students surveyed were members of the junior or senior class during the 1993-94 academic year. They were selected for…

  19. High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases

    PubMed Central

    Zámocký, Marcel; García-Fernández, Queralt; Gasselhuber, Bernhard; Jakopitsch, Christa; Furtmüller, Paul G.; Loewen, Peter C.; Fita, Ignacio; Obinger, Christian; Carpena, Xavi

    2012-01-01

    Catalase-peroxidases (KatGs) are bifunctional heme enzymes widely spread in archaea, bacteria, and lower eukaryotes. Here we present the first crystal structure (1.55 Å resolution) of an eukaryotic KatG, the extracellular or secreted enzyme from the phytopathogenic fungus Magnaporthe grisea. The heme cavity of the homodimeric enzyme is similar to prokaryotic KatGs including the unique distal +Met-Tyr-Trp adduct (where the Trp is further modified by peroxidation) and its associated mobile arginine. The structure also revealed several conspicuous peculiarities that are fully conserved in all secreted eukaryotic KatGs. Peculiarities include the wrapping at the dimer interface of the N-terminal elongations from the two subunits and cysteine residues that cross-link the two subunits. Differential scanning calorimetry and temperature- and urea-mediated unfolding followed by UV-visible, circular dichroism, and fluorescence spectroscopy combined with site-directed mutagenesis demonstrated that secreted eukaryotic KatGs have a significantly higher conformational stability as well as a different unfolding pattern when compared with intracellular eukaryotic and prokaryotic catalase-peroxidases. We discuss these properties with respect to the structure as well as the postulated roles of this metalloenzyme in host-pathogen interactions. PMID:22822072

  20. What Does Quality Programming Mean for High Achieving Students?

    ERIC Educational Resources Information Center

    Samudzi, Cleo

    2008-01-01

    The Missouri Academy of Science, Mathematics and Computing (Missouri Academy) is a two-year accelerated, early-entrance-to-college, residential school that matches the level, complexity and pace of the curriculum with the readiness and motivation of high achieving high school students. The school is a part of Northwest Missouri State University…

  1. High School Employment and Academic Achievement: A Note for Educators

    ERIC Educational Resources Information Center

    Keister, Mary; Hall, Joshua

    2010-01-01

    Educators are often in a position to affect student decisions to work during the school term. This study reviews and summarizes the literature on the effect that employment during high school has on academic achievement. The available evidence suggests that part-time jobs for high school students are beneficial as long as the number of hours…

  2. High-Stakes Testing: Does It Increase Achievement?

    ERIC Educational Resources Information Center

    Nichols, Sharon L.

    2007-01-01

    I review the literature on the impact on student achievement of high-stakes testing. Its popularity as a mechanism for holding educators accountable has triggered studies to examine whether its promise to increase student learning has been fulfilled. The review concludes there is no consistent evidence to suggest high-stakes testing leads to…

  3. Brain Hemisphericity and Mathematics Achievement of High School Students

    ERIC Educational Resources Information Center

    Fernandez, Sanny F.

    2011-01-01

    This study aimed to find out the brain hemisphericity and mathematics achievement of high school students. The respondents of the study were the 168 first year high school students of Colegio de San Jose, during school year 2010-2011 who were chosen through stratified random sampling. The descriptive and interview methods of research were used in…

  4. Exploring High-Achieving Students' Images of Mathematicians

    ERIC Educational Resources Information Center

    Aguilar, Mario Sánchez; Rosas, Alejandro; Zavaleta, Juan Gabriel Molina; Romo-Vázquez, Avenilde

    2016-01-01

    The aim of this study is to describe the images that a group of high-achieving Mexican students hold of mathematicians. For this investigation, we used a research method based on the Draw-A-Scientist Test (DAST) with a sample of 63 Mexican high school students. The group of students' pictorial and written descriptions of mathematicians assisted us…

  5. Achieving the College Dream? Examining Disparities in Access to College Information among High Achieving and Non-High Achieving Latina Students

    ERIC Educational Resources Information Center

    Kimura-Walsh, Erin; Yamamura, Erica K.; Griffin, Kimberly A.; Allen, Walter R.

    2009-01-01

    Using an Opportunity to Learn (OTL) framework, this study examines the college preparatory experiences of Latina high and non-high achievers at an urban Latina/o majority high school. Findings indicate that students relied almost exclusively on school resources to navigate their college preparation process. However, the school provided…

  6. Enhanced thermal stability achieved without increased conformational rigidity at physiological temperatures: spatial propagation of differential flexibility in rubredoxin hybrids.

    PubMed

    LeMaster, David M; Tang, Jianzhong; Paredes, Diana I; Hernández, Griselda

    2005-11-15

    The extreme thermal stability of proteins from hyperthermophilic organisms is widely believed to arise from an increased conformational rigidity in the native state. In apparent contrast to this paradigm, both Pyrococcus furiosus (Pf) rubredoxin, the most thermostable protein characterized to date, and its Clostridium pasteurianum (Cp) mesophile homolog undergo a transient conformational opening of their multi-turn segments, which is more favorable in hyperthermophile proteins below room temperature. Substitution of the hyperthermophile multi-turn sequence into the mesophile protein sequence yields a hybrid, (14-33(Pf)) Cp, that exhibits a 12 degrees increase in its reversible thermal unfolding transition midpoint. Nuclear magnetic resonance (NMR) magnetization transfer-based hydrogen exchange was used to monitor backbone conformational dynamics in the subsecond time regime. Despite the substantially increased thermostability, flexibility throughout the entire main chain of the more thermostable hybrid is equal to or greater than that of the wild type mesophile rubredoxin near its normal growth temperature. In comparison to the identical core residues of the (14-33(Pf)) Cp rubredoxin hybrid, six spatially clustered residues in the parental mesophile protein exhibit a substantially larger temperature dependence of exchange. The exchange behavior of these six residues closely matches that observed in the multi-turn segment, consistent with a more extensive conformational process. These six core residues exhibit a much weaker temperature dependence of exchange in the (14-33(Pf)) Cp hybrid, similar to that observed for the multi-turn segment in its parental Pf rubredoxin. These results suggest that differential temperature dependence of flexibility can underlie variations in thermostability observed for mesophile versus hyperthermophile homologs.

  7. Direct experimental evidence for the high chemical reactivity of α- and β-xylopyranosides adopting a (2,5)B conformation in glycosyl transfer.

    PubMed

    Amorim, Luis; Marcelo, Filipa; Rousseau, Cyril; Nieto, Lidia; Jiménez-Barbero, Jesús; Marrot, Jérôme; Rauter, Amélia P; Sollogoub, Matthieu; Bols, Mikael; Blériot, Yves

    2011-06-20

    The effect of a (2,5)B boat conformation on xyloside reactivity has been investigated by studying the hydrolysis and glycosylation of a series of synthetic xyloside analogues based on a 2-oxabicyclo[2.2.2]octane framework, which forces the xylose analogue to adopt a (2,5)B conformation. The locked β-xylosides were found to hydrolyze 100-1200 times faster than methyl β-D-xylopyranoside, whereas the locked α-xylosides hydrolyzed up to 2×10(4) times faster than methyl α-D-xylopyranoside. A significant rate enhancement was also observed for the glycosylation reaction. The high reactivity of these conformers can be related to the imposition of a (2,5)B conformation, which approximates a transition state (TS) boat conformation. In this way, the energy penalty required to go from the chair to the TS conformation is already paid. These results parallel and support the observation that the GH-11 xylanase family force their substrate to adopt a (2,5)B conformation to achieve highly efficient enzymatic glycosidic bond hydrolysis.

  8. A Study of the Conformational Isomerism of 1-Iodobutane by High Resolution Rotational Spectroscopy

    DOE PAGES

    Arsenault, Eric A.; Obenchain, Daniel A.; Blake, Thomas A.; ...

    2017-03-24

    The first microwave study of 1-iodobutane, performed by Steinmetz et al. in 1977, led to the determination of the B+C parameter for the anti-anti- and gauche-anti-conformers. Nearly 40 years later, in this paper this reinvestigation of 1-iodobutane, by high-resolution microwave spectroscopy, led to the determination of rotational constants, centrifugal distortion constants, nuclear quadrupole coupling constants (NQCCs), and nuclear-spin rotation constants belonging to both of the two previously mentioned conformers, in addition to the gauche-gauche-conformer, which was observed in this frequency regime for the first time. Finally, comparisons between the three conformers of 1-iodobutane and other iodo- and bromoalkanes are made,more » specifically through an analysis of the nuclear quadrupole coupling constants belonging to the iodine and bromine atoms in the respective chemical environments.« less

  9. 77 FR 64183 - Notice of Availability of a Final General Conformity Determination for the California High-Speed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Federal Railroad Administration Notice of Availability of a Final General Conformity Determination for the... advise the public that it issued a Final General Conformity Determination for the Merced to Fresno... General Conformity requirements. The California High Speed Rail Authority (Authority), as the...

  10. Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids

    PubMed Central

    2016-01-01

    High-density lipoprotein (HDL) nanoparticles doped with gadolinium lipids can be used as magnetic resonance imaging diagnostic agents for atherosclerosis. In this study, HDL nanoparticles with different molar fractions of gadolinium lipids (0 < xGd-lipids < 0.33) were prepared, and the MR relaxivity values (r1 and r2) for all compositions were measured. Both r1 and r2 parameters reached a maximal value at a molar fraction of approximately xGd-lipids = 0.2. Higher payloads of gadolinium did not significantly increase relaxivity values but induced changes in the structure of HDL, increasing the size of the particles from dH = 8.2 ± 1.6 to 51.7 ± 7.3 nm. High payloads of gadolinium lipids trigger conformational changes in HDL, with potential effects on the in vivo behavior of the nanoparticles. PMID:27713933

  11. Self-Esteem and Academic Achievement of High School Students

    ERIC Educational Resources Information Center

    Moradi Sheykhjan, Tohid; Jabari, Kamran; Rajeswari, K.

    2014-01-01

    The primary purpose of this study was to determine the influence of self-esteem on academic achievement among high school students in Miandoab City of Iran. The methodology of the research is descriptive and correlation that descriptive and inferential statistics were used to analyze the data. Statistical Society includes male and female high…

  12. Comparison of Achievement of Students in High School Courses

    ERIC Educational Resources Information Center

    Troxel, Verne A.

    1970-01-01

    Compares student achievements on common objectives of CHEMS, CBA, and "Modern Chemistry high school chemistry courses. Results indicate the three couses are not equally effective in meeting their objectives. CHEMS and CBA develop a better understanding of chemistry and science, as well as develop greater ability for critical thinking. CBA…

  13. Relationship between High School Leadership Team Practices and Student Achievement

    ERIC Educational Resources Information Center

    McInnis, Timothy M.

    2009-01-01

    This study investigated if a relationship existed between student achievement in 10th grade Missouri Assessment Program mathematics and 11th grade communication arts scores in 2007 and high school leadership team perceptions of the extent to which they demonstrated leadership practices. The secondary purpose was to compare perceptional…

  14. Early College High School: Closing the Latino Achievement Gap

    ERIC Educational Resources Information Center

    Beall, Kristen Ann

    2016-01-01

    The population of United States Latino students is growing at a rapid rate but their academic achievement lags behind white and Asian students. This issue has significant consequences for the nation's economy, as the job market continues to demand more education and better skills. Early College High School programs have the potential to improve…

  15. Contribution of high-energy conformations to NMR chemical shifts, a DFT-BOMD study.

    PubMed

    Goursot, A; Mineva, T; Vásquez-Pérez, J M; Calaminici, P; Köster, A M; Salahub, D R

    2013-01-21

    This paper highlights the relevance of including the high-energy conformational states sampled by Born-Oppenheimer molecular dynamics (BOMD) in the calculation of time-averaged NMR chemical shifts. Our case study is the very flexible glycerol molecule that undergoes interconversion between conformers in a nonrandom way. Along the sequence of structures from one backbone conformer to another, transition states have been identified. The three (13)C NMR chemical shifts of the molecule were estimated by averaging their calculated values over a large set of BOMD snapshots. The simulation time needed to obtain a good agreement with the two signals present in the experimental spectrum is shown to be dependent on the atomic orbital basis set used for the dynamics, with a necessary longer trajectory for the most extended basis sets. The large structural deformations with respect to the optimized conformer geometries that occur along the dynamics are related to a kinetically driven conformer distribution. Calculated conformer type populations are in good agreement with experimental gas phase microwave results.

  16. High-Dose Conformal Radiotherapy for Patients With Stage III Non-Small-Cell Lung Carcinoma

    SciTech Connect

    Nakayama, Hidetsugu; Satoh, Hiroaki; Kurishima, Koichi; Ishikawa, Hiroichi; Tokuuye, Koichi

    2010-11-01

    Purpose: To determine the effectiveness of high-dose conformal radiotherapy to the involved field for patients with Stage III non-small-cell lung cancer (NSCLC). Methods and Materials: Between May 1999 and April 2006, a total of 100 consecutive patients with inoperable Stage IIIA or IIIB NSCLC with a performance score of 0 to 2 and treatment by radical radiotherapy combined with chemotherapy were included. Up to August 2002, 33 patients underwent conventional radiotherapy of 56 Gy to 66 Gy using anteroposterior opposite ports to the primary tumor and elective lymph nodes (conventional group). After September 2002, the remaining 67 patients underwent high-dose radiotherapy of 66 Gy to 84 Gy to the involved volume with three-dimensional (3-D) conformal radiotherapy (conformal group). Results: The median survival was 13.2 months (95% confidence interval [CI], 7.5-18.5 months) in the conventional group and 17.3 months (95% CI, 10.7- 24.0 months) in the conformal group. The overall survival at 3 years were 9.1% (95% CI, -0.7-18.9%) in the conventional group and 31.0% (95% CI, 18.9-43.1%) in the conformal group; the conformal group had a significantly better overall survival (p < 0.05). The radiotherapy method (hazard ratio = 0.55, p < 0.05) and performance status (hazard ratio = 1.48, p < 0.05) were shown to be statistically significant independent prognostic factors. Conclusions: Based on the practical experience reported here, 3-D conformal radiotherapy allowed dose escalation without excessive toxicity, and may improve overall survival rates for patients with Stage III NSCLC.

  17. Parent Involvement Practices of High-Achieving Elementary Science Students

    NASA Astrophysics Data System (ADS)

    Waller, Samara Susan

    This study addressed a prevalence of low achievement in science courses in an urban school district in Georgia. National leaders and educators have identified the improvement of science proficiency as critical to the future of American industry. The purpose of this study was to examine parent involvement in this school district and its contribution to the academic achievement of successful science students. Social capital theory guided this study by suggesting that students achieve best when investments are made into their academic and social development. A collective case study qualitative research design was used to interview 9 parent participants at 2 elementary schools whose children scored in the exceeds category on the Science CRCT. The research questions focused on what these parents did at home to support their children's academic achievement. Data were collected using a semi-structured interview protocol and analyzed through the categorical aggregation of transcribed interviews. Key findings revealed that the parents invested time and resources in 3 practices: communicating high expectations, supporting and developing key skills, and communicating with teachers. These findings contribute to social change at both the local and community level by creating a starting point for teachers, principals, and district leaders to reexamine the value of parent input in the educational process, and by providing data to support the revision of current parent involvement policies. Possibilities for further study building upon the findings of this study may focus on student perceptions of their parents' parenting as it relates to their science achievement.

  18. The Construction of Black High-Achiever Identities in a Predominantly White High School

    ERIC Educational Resources Information Center

    Andrews, Dorinda J. Carter

    2009-01-01

    In this article, I examine how black students construct their racial and achievement self-concepts in a predominantly white high school to enact a black achiever identity. By listening to these students talk about the importance of race and achievement to their lives, I came to understand how racialized the task of achieving was for them even…

  19. Improving science achievement at high-poverty urban middle schools

    NASA Astrophysics Data System (ADS)

    Ruby, Allen

    2006-11-01

    A large percentage of U.S. students attending high-poverty urban middle schools achieve low levels of science proficiency, posing significant challenges to their success in high school science and to national and local efforts to reform science education. Through its work in Philadelphia schools, the Center for Social Organization of Schools at Johns Hopkins University developed a teacher-support model to address variation in science curricula, lack of materials, and underprepared teachers that combined with initial low levels of proficiency block improvements in science achievement. The model includes a common science curriculum based on NSF-supported materials commercially available, ongoing teacher professional development built around day-to-day lessons, and regular in-class support of teachers by expert peer coaches. One cohort of students at three Philadelphia middle schools using the model was followed from the end of fourth grade through seventh grade. Their gains in science achievement and achievement levels were substantially greater than students at 3 matched control schools and the 23 district middle schools serving a similar student population. Under school-by-school comparisons, these results held for the two schools with adequate implementation. Using widely available materials and techniques, the model can be adopted and modified by school partners and districts.

  20. The Will to Achieve: A Phenomenological Study of the Experiences of African American High Achieving Students and Their Parents

    ERIC Educational Resources Information Center

    Spencer, Natalie Faye

    2012-01-01

    The purpose of this research study was to understand the experiences of high achieving African American students and their parents. The experiences of high achieving African American students and their parents have been missing from literature on the academic achievement of African American students. Much of the literature that has been published…

  1. Achieving High Performance on the i860 Microprocessor

    NASA Technical Reports Server (NTRS)

    Lee, King; Kutler, Paul (Technical Monitor)

    1998-01-01

    The i860 is a high performance microprocessor used in the Intel Touchstone project. This paper proposes a paradigm for programming the i860 that is modelled on the vector instructions of the Cray computers. Fortran callable assembler subroutines were written that mimic the concurrent vector instructions of the Cray. Cache takes the place of vector registers. Using this paradigm we have achieved twice the performance of compiled code on a traditional solve.

  2. Retention of nativelike conformation by proteins embedded in high external electric fields

    NASA Astrophysics Data System (ADS)

    Pompa, P. P.; Bramanti, A.; Maruccio, G.; Cingolani, R.; De Rienzo, F.; Corni, S.; Di Felice, R.; Rinaldi, R.

    2005-05-01

    In this Communication, we show that proteins embedded in high external electric fields are capable of retaining a nativelike fold pattern. We have tested the metalloprotein azurin, immobilized onto SiO2 substrates in air with proper electrode configuration, by applying static fields up to 106-107V/m. The effects on the conformational properties of protein molecules have been determined by means of intrinsic fluorescence measurements. Experimental results indicate that no significant field-induced conformational alteration occurs. Such results are also discussed and supported by theoretical predictions of the inner protein fields.

  3. Experiences of High-Achieving High School Students Who Have Taken Multiple Concurrent Advanced Placement Courses

    ERIC Educational Resources Information Center

    Milburn, Kristine M.

    2011-01-01

    Problem: An increasing number of high-achieving American high school students are enrolling in multiple Advanced Placement (AP) courses. As a result, high schools face a growing need to understand the impact of taking multiple AP courses concurrently on the social-emotional lives of high-achieving students. Procedures: This phenomenological…

  4. Interface Strategy To Achieve Tunable High Frequency Attenuation.

    PubMed

    Lv, Hualiang; Zhang, Haiqian; Ji, Guangbin; Xu, Zhichuan J

    2016-03-01

    Among all polarizations, the interface polarization effect is the most effective, especially at high frequency. The design of various ferrite/iron interfaces can significantly enhance the materials' dielectric loss ability at high frequency. This paper presents a simple method to generate ferrite/iron interfaces to enhance the microwave attenuation at high frequency. The ferrites were coated onto carbonyl iron and could be varied to ZnFe2O4, CoFe2O4, Fe3O4, and NiFe2O4. Due to the ferrite/iron interface inducing a stronger dielectric loss effect, all of these materials achieved broad effective frequency width at a coating layer as thin as 1.5 mm. In particular, an effective frequency width of 6.2 GHz could be gained from the Fe@NiFe2O4 composite.

  5. The Structure of a High Fidelity DNA Polymerase Bound to a Mismatched Nucleotide Reveals an ;Ajar; Intermediate Conformation in the Nucleotide Selection Mechanism

    SciTech Connect

    Wu, Eugene Y.; Beese, Lorena S.

    2011-10-10

    To achieve accurate DNA synthesis, DNA polymerases must rapidly sample and discriminate against incorrect nucleotides. Here we report the crystal structure of a high fidelity DNA polymerase I bound to DNA primer-template caught in the act of binding a mismatched (dG:dTTP) nucleoside triphosphate. The polymerase adopts a conformation in between the previously established 'open' and 'closed' states. In this 'ajar' conformation, the template base has moved into the insertion site but misaligns an incorrect nucleotide relative to the primer terminus. The displacement of a conserved active site tyrosine in the insertion site by the template base is accommodated by a distinctive kink in the polymerase O helix, resulting in a partially open ternary complex. We suggest that the ajar conformation allows the template to probe incoming nucleotides for complementarity before closure of the enzyme around the substrate. Based on solution fluorescence, kinetics, and crystallographic analyses of wild-type and mutant polymerases reported here, we present a three-state reaction pathway in which nucleotides either pass through this intermediate conformation to the closed conformation and catalysis or are misaligned within the intermediate, leading to destabilization of the closed conformation.

  6. Structural investigation of ribonuclease A conformational preferences using high pressure protein crystallography

    NASA Astrophysics Data System (ADS)

    Kurpiewska, Katarzyna; Dziubek, Kamil; Katrusiak, Andrzej; Font, Josep; Ribò, Marc; Vilanova, Maria; Lewiński, Krzysztof

    2016-04-01

    Hydrostatic pressure in range 0.1-1.5 GPa is used to modify biological system behaviour mostly in biophysical studies of proteins in solution. Due to specific influence on the system equilibrium high pressure can act as a filter that enables to identify and investigate higher energy protein conformers. The idea of the presented experiments is to examine the behaviour of RNase A molecule under high pressure before and after introduction of destabilizing mutation. For the first time crystal structures of wild-type bovine pancreatic ribonuclease A and its markedly less stable variant modified at position Ile106 were determined at different pressures. X-ray diffraction experiments at high pressure showed that the secondary structure of RNase A is well preserved even beyond 0.67 GPa at room temperature. Detailed structural analysis of ribonuclease A conformation observed under high pressure revealed that pressure influences hydrogen bonds pattern, cavity size and packing of molecule.

  7. Unlocking Emergent Talent: Supporting High Achievement of Low-Income, High Ability Students

    ERIC Educational Resources Information Center

    Olszewski-Kubilius, Paula; Clarenbach, Jane

    2012-01-01

    This report takes a comprehensive look at achievement for low-income promising learners--past, present, and future. At its core, it challenges the nation to move beyond its near-singular focus of achieving minimum performance for all students, to identifying and developing the talent of all students who are capable of high achievement, including…

  8. X-ray Crystallography at High Pressure to Probe Conformational Fluctuations in Biological Macromolecules

    SciTech Connect

    Girard, Eric; Fourme, Roger; Kahn, Richard; Dhaussy, Anne-Claire; Ascone, Isabella; Mezouar, Mohamed

    2007-01-19

    Macromolecular crystals can be compressed hydrostatically at room temperature in a diamond anvil cell. The quality of diffraction data recorded on the ESRF ID30/ID27 beamlines using a parallel X-ray beam of ultra-short wavelength can meet usual standards. The 3D structures of proteins (monomeric, dimeric and tetrameric) and of a virus have been refined both at atmospheric and at high pressure. High pressure is a way to explore the high energy landscape of macromolecular systems, from the fully folded state to the unfolded state. High energy conformers of biological significance can be selected and trapped under high pressure.

  9. Achieving unusual oxidation state of matter under high pressure

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoli; Lin, Haiqing; Ma, Yanming; Miao, Maosheng

    2013-03-01

    Pressure has many effects to matter including the reduction of the volume, the increase of the coordination number and the broadening of the band-widths. In the past, most of the high-pressure studies focused on structural and electronic state phase transitions. Using first principles calculations and a bias-free structural search method, we will demonstrate that high pressure can lead to high oxidation state of elements that can never be achieved under ambient condition, making high pressure technique a nice tool to explore many traditional topics in solid state and molecular chemistry. As an example, we will show that Hg can transfer the electrons in its outmost d shell to F atoms and form HgF4 molecular crystals under pressure, thereby acting as a true transition metal. Group IIB elements, including Zn, Cd, and Hg are usually defined as post-transition metals because they are commonly oxidized only to the +2 state. Their d shells are completely filled and do not participate in the formation of chemical bonds. Although the synthesis of HgF4 molecules in gas phase was reported before, the molecules show strong instabilities and dissociate. Therefore, the transition metal propensity of Hg remains an open question.

  10. Achieving high energy absorption capacity in cellular bulk metallic glasses

    PubMed Central

    Chen, S. H.; Chan, K. C.; Wu, F. F.; Xia, L.

    2015-01-01

    Cellular bulk metallic glasses (BMGs) have exhibited excellent energy-absorption performance by inheriting superior strength from the parent BMGs. However, how to achieve high energy absorption capacity in cellular BMGs is vital but mysterious. In this work, using step-by-step observations of the deformation evolution of a series of cellular BMGs, the underlying mechanisms for the remarkable energy absorption capacity have been investigated by studying two influencing key factors: the peak stress and the decay of the peak stress during the plastic-flow plateau stages. An analytical model of the peak stress has been proposed, and the predicted results agree well with the experimental data. The decay of the peak stress has been attributed to the geometry change of the macroscopic cells, the formation of shear bands in the middle of the struts, and the “work-softening” nature of BMGs. The influencing factors such as the effect of the strut thickness and the number of unit cells have also been investigated and discussed. Strategies for achieving higher energy absorption capacity in cellular BMGs have been proposed. PMID:25973781

  11. Achieving High Resolution Timer Events in Virtualized Environment

    PubMed Central

    Adamczyk, Blazej; Chydzinski, Andrzej

    2015-01-01

    Virtual Machine Monitors (VMM) have become popular in different application areas. Some applications may require to generate the timer events with high resolution and precision. This however may be challenging due to the complexity of VMMs. In this paper we focus on the timer functionality provided by five different VMMs—Xen, KVM, Qemu, VirtualBox and VMWare. Firstly, we evaluate resolutions and precisions of their timer events. Apparently, provided resolutions and precisions are far too low for some applications (e.g. networking applications with the quality of service). Then, using Xen virtualization we demonstrate the improved timer design that greatly enhances both the resolution and precision of achieved timer events. PMID:26177366

  12. Achievement of high nitrite accumulation via endogenous partial denitrification (EPD).

    PubMed

    Ji, Jiantao; Peng, Yongzhen; Wang, Bo; Wang, Shuying

    2017-01-01

    This study proposed a novel strategy for achievement of partial denitrification driven by endogenous carbon sources in an anaerobic/anoxic/aerobic activated sludge system. Results showed that in the steady-stage, the nitrate-to-nitrite transformation ratio (NTR) was kept at around 87% without nitrate in the effluent. During the anaerobic period, exogenous carbon sources was completely taken up, accompanied by the consumption of glycogen and production of polyhydroxyalkanoates (PHAs). During the anoxic period, nitrate was reduced to nitrite by using PHAs as carbon sources, followed by the replenishment of glycogen. Thus, the phenotype of denitrifying GAOs was clearly observed and endogenous partial denitrification (EPD) occurred. Furthermore, results showed the nitrate reduction was prior to the nitrite reduction in the presence of nitrate, which led to the high nitrite accumulation.

  13. Achieving ultra-high temperatures with a resistive emitter array

    NASA Astrophysics Data System (ADS)

    Danielson, Tom; Franks, Greg; Holmes, Nicholas; LaVeigne, Joe; Matis, Greg; McHugh, Steve; Norton, Dennis; Vengel, Tony; Lannon, John; Goodwin, Scott

    2016-05-01

    The rapid development of very-large format infrared detector arrays has challenged the IR scene projector community to also develop larger-format infrared emitter arrays to support the testing of systems incorporating these detectors. In addition to larger formats, many scene projector users require much higher simulated temperatures than can be generated with current technology in order to fully evaluate the performance of their systems and associated processing algorithms. Under the Ultra High Temperature (UHT) development program, Santa Barbara Infrared Inc. (SBIR) is developing a new infrared scene projector architecture capable of producing both very large format (>1024 x 1024) resistive emitter arrays and improved emitter pixel technology capable of simulating very high apparent temperatures. During earlier phases of the program, SBIR demonstrated materials with MWIR apparent temperatures in excess of 1400 K. New emitter materials have subsequently been selected to produce pixels that achieve even higher apparent temperatures. Test results from pixels fabricated using the new material set will be presented and discussed. A 'scalable' Read In Integrated Circuit (RIIC) is also being developed under the same UHT program to drive the high temperature pixels. This RIIC will utilize through-silicon via (TSV) and Quilt Packaging (QP) technologies to allow seamless tiling of multiple chips to fabricate very large arrays, and thus overcome the yield limitations inherent in large-scale integrated circuits. Results of design verification testing of the completed RIIC will be presented and discussed.

  14. High resolution single strand conformation polymorphism analysis using formamide and ethidium bromide staining.

    PubMed Central

    Xie, T; Ho, S L; Ma, O C

    1997-01-01

    Single strand conformation polymorphism (SSCP) analysis using ethidium bromide can be improved by adding formamide as the denaturant. This gives higher resolution than previous SSCP methods; it had 100% sensitivity in the discrimination of 14 PCR samples from two different genes, even for a long fragment close to the upper limit of 250 base pairs. This modified procedure is a rapid, simple, safe, and yet highly sensitive method for detecting structural differences in DNA fragments. Images PMID:9497922

  15. Comparative visualization of protein conformations using large high resolution displays with gestures and body tracking

    NASA Astrophysics Data System (ADS)

    Marangoni, Matt; Wischgoll, Thomas

    2015-01-01

    Automatically identifying protein conformations can yield multiple candidate structures. Potential candidates are examined further to cull false positives. Individual conformations and the collection are compared when seeking flaws. Desktop displays are ineffective due to limited size and resolution. Thus a user must sacrifice large scale content by viewing the micro level with high detail or view the macro level while forfeiting small details. We address this ultimatum by utilizing multiple, high resolution displays. Using 27, 50", high resolution displays with active, stereoscopic 3D, and modified virtual environment software, each display presents a protein users can manipulate. Such an environment enables users to gain extensive insight both at the micro and macro levels when performing structural comparisons among the candidate structures. Integrating stereoscopic 3D improves the user's ability to judge conformations spatial relationships. In order to facilitate intuitive interaction, gesture recognition as well as body tracking are used. The user is able to look at the protein of interest, select a modality via gesture, and the user's motions provide intuitive navigation functions such as panning, rotating, and zooming. Using this approach, users are able to perform protein structure comparison through intuitive controls without sacrificing important visual details at any scale.

  16. Equivalent Biochemical Control and Improved Prostate-Specific Antigen Nadir After Permanent Prostate Seed Implant Brachytherapy Versus High-Dose Three-Dimensional Conformal Radiotherapy and High-Dose Conformal Proton Beam Radiotherapy Boost

    SciTech Connect

    Jabbari, Siavash; Weinberg, Vivian K.; Shinohara, Katsuto; Speight, Joycelyn L.; Gottschalk, Alexander R.; Hsu, I.-C.; Pickett, Barby; McLaughlin, Patrick W.; Sandler, Howard M.; Roach, Mack

    2010-01-15

    Purpose: Permanent prostate implant brachytherapy (PPI), three-dimensional conformal radiotherapy (3D-CRT), and conformal proton beam radiotherapy (CPBRT) are used in the treatment of localized prostate cancer, although no head-to-head trials have compared these modalities. We studied the biochemical control (biochemical no evidence of disease [bNED]) and prostate-specific antigen (PSA) nadir achieved with contemporary PPI, and evaluated it against 3D-CRT and CPBRT. Patients and Methods: A total of 249 patients were treated with PPI at the University of California, San Francisco, and the outcomes were compared with those from a 3D-CRT cohort and the published results of a high-dose CPBRT boost (CPBRTB) trial. For each comparison, subsets of the PPI cohort were selected with patient and disease criteria similar to those of the reference group. Results: With a median follow-up of 5.3 years, the bNED rate at 5 and 7 years achieved with PPI was 92% and 86%, respectively, using the American Society for Therapeutic Radiology and Oncology (ASTRO) definition, and 93% using the PSA nadir plus 2 ng/mL definition. Using the ASTRO definition, a 5-year bNED rate of 78% was achieved for the 3D-CRT patients compared with 94% for a comparable PPI subset and 93% vs. 92%, respectively, using the PSA nadir plus 2 ng/mL definition. The median PSA nadir for patients treated with PPI and 3D-CRT was 0.10 and 0.40 ng/mL, respectively (p < .0001). For the CPBRT comparison, the 5-year bNED rate after a CPBRTB was 91% using the ASTRO definition vs. 93% for a similar group of PPI patients. A greater proportion of PPI patients achieved a lower PSA nadir compared with those achieved in the CPBRTB trial (PSA nadir <=0.5 ng/mL, 91% vs. 59%, respectively). Conclusion: We have demonstrated excellent outcomes in low- to intermediate-risk patients treated with PPI, suggesting at least equivalent 5-year bNED rates and a greater proportion of men achieving lower PSA nadirs compared with 3D-CRT or

  17. Graphitic Carbon Conformal Coating of Mesoporous TiO2 Hollow Spheres for High-Performance Lithium Ion Battery Anodes.

    PubMed

    Liu, Hao; Li, Wei; Shen, Dengke; Zhao, Dongyuan; Wang, Guoxiu

    2015-10-14

    Rational design and controllable synthesis of TiO2 based materials with unique microstructure, high reactivity, and excellent electrochemical performance for lithium ion batteries are crucially desired. In this paper, we developed a versatile route to synthesize hollow TiO2/graphitic carbon (H-TiO2/GC) spheres with superior electrochemical performance. The as-prepared mesoporous H-TiO2/GC hollow spheres present a high specific surface area (298 m(2) g(-1)), a high pore volume (0.31 cm(3) g(-1)), a large pore size (∼5 nm), well-defined hollow structure (monodispersed size of 600 nm and inner diameter of ∼400 nm, shell thickness of 100 nm), and small nanocrystals of anatase TiO2 (∼8 nm) conformably encapsulated in ultrathin graphitic carbon layers. As a result, the H-TiO2/GC hollow spheres achieve excellent electrochemical reactivity and stability as an anode material for lithium ion batteries. A high specific capacity of 137 mAh g(-1) can be achieved up to 1000 cycles at a current density of 1 A g(-1) (5 C). We believe that the mesoporous H-TiO2/GC hollow spheres are expected to be applied as a high-performance electrode material for next generation lithium ion batteries.

  18. How to achieve high-level expression of microbial enzymes

    PubMed Central

    Liu, Long; Yang, Haiquan; Shin, Hyun-dong; Chen, Rachel R.; Li, Jianghua; Du, Guocheng; Chen, Jian

    2013-01-01

    Microbial enzymes have been used in a large number of fields, such as chemical, agricultural and biopharmaceutical industries. The enzyme production rate and yield are the main factors to consider when choosing the appropriate expression system for the production of recombinant proteins. Recombinant enzymes have been expressed in bacteria (e.g., Escherichia coli, Bacillus and lactic acid bacteria), filamentous fungi (e.g., Aspergillus) and yeasts (e.g., Pichia pastoris). The favorable and very advantageous characteristics of these species have resulted in an increasing number of biotechnological applications. Bacterial hosts (e.g., E. coli) can be used to quickly and easily overexpress recombinant enzymes; however, bacterial systems cannot express very large proteins and proteins that require post-translational modifications. The main bacterial expression hosts, with the exception of lactic acid bacteria and filamentous fungi, can produce several toxins which are not compatible with the expression of recombinant enzymes in food and drugs. However, due to the multiplicity of the physiological impacts arising from high-level expression of genes encoding the enzymes and expression hosts, the goal of overproduction can hardly be achieved, and therefore, the yield of recombinant enzymes is limited. In this review, the recent strategies used for the high-level expression of microbial enzymes in the hosts mentioned above are summarized and the prospects are also discussed. We hope this review will contribute to the development of the enzyme-related research field. PMID:23686280

  19. Effects of Partner's Ability on the Achievement and Conceptual Organization of High-Achieving Fifth-Grade Students.

    ERIC Educational Resources Information Center

    Carter, Glenda; Jones, M. Gail; Rua, Melissa

    2003-01-01

    Investigates high-achieving fifth-grade students' achievement gains and conceptual reorganization on convection. Features an instructional sequence of three dyadic inquiry investigations related to convection currents as well as pre- and post-assessment consisting of a multiple-choice test, a card sorting task, construction of a concept map, and…

  20. Comparison of the Level of Using Metacognitive Strategies during Study between High Achieving and Low Achieving Prospective Teachers

    ERIC Educational Resources Information Center

    Doganay, Ahmet; Demir, Ozden

    2011-01-01

    The main purpose of this study is to compare the level of using metacognitive strategies during study between high achieving and low achieving prospective classroom teachers. This study was designed as a mixed method study. Metacognitive Learning Strategies Scale developed by Namlu (2004) was used to measure the use of metacognitive strategies…

  1. Effects of high pressure modification on conformation and gelation properties of myofibrillar protein.

    PubMed

    Zhang, Ziye; Yang, Yuling; Zhou, Peng; Zhang, Xing; Wang, Jingyu

    2017-02-15

    The effects of high pressure (HP) treatment (100-500MPa) on conformation and gelation properties of myofibrillar protein (MP) were investigated. As pressure increased (0.1-500MPa), α-helix and β-sheet changed into random coil and β-turn, proteins unfolded to expose interior hydrophobic and sulfhydryl groups, therefore surface hydrophobicity and formation of disulfide bonds were strengthened. At 200MPa, protein solubility and gel hardness reached their maximum value, particle size had minimum value, and gel microstructure was dense and uniform. DSC data showed that actin and myosin completely denatured at 300MPa and 400MPa, respectively. Rheological modulus (G' and G″) of HP-treated MP decreased as pressure increased during thermal gelation. Moderate HP treatment (≦200MPa) strengthened gelation properties of MP, while stronger HP treatment (⩾300MPa) weakened the gelation properties. 200MPa was the optimum pressure level for modifying MP conformation to improve its gelation properties.

  2. Achieving High Throughput for Data Transfer over ATM Networks

    NASA Technical Reports Server (NTRS)

    Johnson, Marjory J.; Townsend, Jeffrey N.

    1996-01-01

    File-transfer rates for ftp are often reported to be relatively slow, compared to the raw bandwidth available in emerging gigabit networks. While a major bottleneck is disk I/O, protocol issues impact performance as well. Ftp was developed and optimized for use over the TCP/IP protocol stack of the Internet. However, TCP has been shown to run inefficiently over ATM. In an effort to maximize network throughput, data-transfer protocols can be developed to run over UDP or directly over IP, rather than over TCP. If error-free transmission is required, techniques for achieving reliable transmission can be included as part of the transfer protocol. However, selected image-processing applications can tolerate a low level of errors in images that are transmitted over a network. In this paper we report on experimental work to develop a high-throughput protocol for unreliable data transfer over ATM networks. We attempt to maximize throughput by keeping the communications pipe full, but still keep packet loss under five percent. We use the Bay Area Gigabit Network Testbed as our experimental platform.

  3. Does Recreational Computer Use Affect High School Achievement?

    ERIC Educational Resources Information Center

    Bowers, Alex J.; Berland, Matthew

    2013-01-01

    Historically, the relationship between student academic achievement and use of computers for fun and video gaming has been described from a multitude of perspectives, from positive, to negative, to neutral. However, recent research has indicated that computer use and video gaming may be positively associated with achievement, yet these studies…

  4. Student Perception of Academic Achievement Factors at High School

    ERIC Educational Resources Information Center

    Bahar, Mustafa

    2016-01-01

    Measuring the quality of the "product" is elemental in education, and most studies depend on observational data about student achievement factors, focusing overwhelmingly on quantitative data namely achievement scores, school data like attendance, facilities, expenditure class size, etc. But there is little evidence of learner…

  5. High-Achieving High School Students and Not so High-Achieving College Students: A Look at Lack of Self-Control, Academic Ability, and Performance in College

    ERIC Educational Resources Information Center

    Honken, Nora B.; Ralston, Patricia A. S.

    2013-01-01

    This study investigated the relationship among lack of self-control, academic ability, and academic performance for a cohort of freshman engineering students who were, with a few exceptions, extremely high achievers in high school. Structural equation modeling analysis led to the conclusion that lack of self-control in high school, as measured by…

  6. Threatened and Placed at Risk: High Achieving African American Males in Urban High Schools

    ERIC Educational Resources Information Center

    McGee, Ebony O.

    2013-01-01

    This study investigated the risk and protective factors of 11 high-achieving African American males attending 4 urban charter high schools in a Midwestern city to determine what factors account for their resilience and success in mathematics courses, and in high school more generally. This research was guided by a Phenomenological Variant of…

  7. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin.

    PubMed

    Bjerregaard, Henriette; Severinsen, Kasper; Said, Saida; Wiborg, Ove; Sinning, Steffen

    2015-03-20

    Serotonergic neurotransmission is modulated by the membrane-embedded serotonin transporter (SERT). SERT mediates the reuptake of serotonin into the presynaptic neurons. Conformational changes in SERT occur upon binding of ions and substrate and are crucial for translocation of serotonin across the membrane. Our understanding of these conformational changes is mainly based on crystal structures of a bacterial homolog in various conformations, derived homology models of eukaryotic neurotransmitter transporters, and substituted cysteine accessibility method of SERT. However, the dynamic changes that occur in the human SERT upon binding of ions, the translocation of substrate, and the role of cholesterol in this interplay are not fully elucidated. Here we show that serotonin induces a dualistic conformational response in SERT. We exploited the substituted cysteine scanning method under conditions that were sensitized to detect a more outward-facing conformation of SERT. We found a novel high affinity outward-facing conformational state of the human SERT induced by serotonin. The ionic requirements for this new conformational response to serotonin mirror the ionic requirements for translocation. Furthermore, we found that membrane cholesterol plays a role in the dualistic conformational response in SERT induced by serotonin. Our results indicate the existence of a subpopulation of SERT responding differently to serotonin binding than hitherto believed and that membrane cholesterol plays a role in this subpopulation of SERT.

  8. Plasma-assisted atomic layer deposition of conformal Pt films in high aspect ratio trenches.

    PubMed

    Erkens, I J M; Verheijen, M A; Knoops, H C M; Keuning, W; Roozeboom, F; Kessels, W M M

    2017-02-07

    To date, conventional thermal atomic layer deposition (ALD) has been the method of choice to deposit high-quality Pt thin films grown typically from (MeCp)PtMe3 vapor and O2 gas at 300 °C. Plasma-assisted ALD of Pt using O2 plasma can offer several advantages over thermal ALD, such as faster nucleation and deposition at lower temperatures. In this work, it is demonstrated that plasma-assisted ALD at 300 °C also allows for the deposition of highly conformal Pt films in trenches with high aspect ratio ranging from 3 to 34. Scanning electron microscopy inspection revealed that the conformality of the deposited Pt films was 100% in trenches with aspect ratio (AR) up to 34. These results were corroborated by high-precision layer thickness measurements by transmission electron microscopy for trenches with an aspect ratio of 22. The role of the surface recombination of O-radicals and the contribution of thermal ALD reactions is discussed.

  9. Plasma-assisted atomic layer deposition of conformal Pt films in high aspect ratio trenches

    NASA Astrophysics Data System (ADS)

    Erkens, I. J. M.; Verheijen, M. A.; Knoops, H. C. M.; Keuning, W.; Roozeboom, F.; Kessels, W. M. M.

    2017-02-01

    To date, conventional thermal atomic layer deposition (ALD) has been the method of choice to deposit high-quality Pt thin films grown typically from (MeCp)PtMe3 vapor and O2 gas at 300 °C. Plasma-assisted ALD of Pt using O2 plasma can offer several advantages over thermal ALD, such as faster nucleation and deposition at lower temperatures. In this work, it is demonstrated that plasma-assisted ALD at 300 °C also allows for the deposition of highly conformal Pt films in trenches with high aspect ratio ranging from 3 to 34. Scanning electron microscopy inspection revealed that the conformality of the deposited Pt films was 100% in trenches with aspect ratio (AR) up to 34. These results were corroborated by high-precision layer thickness measurements by transmission electron microscopy for trenches with an aspect ratio of 22. The role of the surface recombination of O-radicals and the contribution of thermal ALD reactions is discussed.

  10. The Effect of Music Participation on Mathematical Achievement and Overall Academic Achievement of High School Students

    ERIC Educational Resources Information Center

    Cox, H. A.; Stephens, L. J.

    2006-01-01

    A study was conducted on high school students, comparing those with some music credits to those with none. No statistically significant difference was found in their mean math grade point averages (GPA) or their mean cumulative GPAs. Students were then separated into two groups based on the number of music credits. Students who had earned at least…

  11. LDRD Project 52523 final report :Atomic layer deposition of highly conformal tribological coatings.

    SciTech Connect

    Jungk, John Michael; Dugger, Michael Thomas; George, Steve M.; Prasad, Somuri V.; Grubbs, Robert K.; Moody, Neville Reid; Mayer, Thomas Michael; Scharf, Thomas W.; Goeke, Ronald S.; Gerberich, William W.

    2005-10-01

    Friction and wear are major concerns in the performance and reliability of micromechanical (MEMS) devices. While a variety of lubricant and wear resistant coatings are known which we might consider for application to MEMS devices, the severe geometric constraints of many micromechanical systems (high aspect ratios, shadowed surfaces) make most deposition methods for friction and wear-resistance coatings impossible. In this program we have produced and evaluate highly conformal, tribological coatings, deposited by atomic layer deposition (ALD), for use on surface micromachined (SMM) and LIGA structures. ALD is a chemical vapor deposition process using sequential exposure of reagents and self-limiting surface chemistry, saturating at a maximum of one monolayer per exposure cycle. The self-limiting chemistry results in conformal coating of high aspect ratio structures, with monolayer precision. ALD of a wide variety of materials is possible, but there have been no studies of structural, mechanical, and tribological properties of these films. We have developed processes for depositing thin (<100 nm) conformal coatings of selected hard and lubricious films (Al2O3, ZnO, WS2, W, and W/Al{sub 2}O{sub 3} nanolaminates), and measured their chemical, physical, mechanical and tribological properties. A significant challenge in this program was to develop instrumentation and quantitative test procedures, which did not exist, for friction, wear, film/substrate adhesion, elastic properties, stress, etc., of extremely thin films and nanolaminates. New scanning probe and nanoindentation techniques have been employed along with detailed mechanics-based models to evaluate these properties at small loads characteristic of microsystem operation. We emphasize deposition processes and fundamental properties of ALD materials, however we have also evaluated applications and film performance for model SMM and LIGA devices.

  12. Achieving Energy Savings with Highly-Controlled Lighting in an Open-Plan Office

    SciTech Connect

    Rubinstein, Francis; Enscoe, Abby

    2010-04-19

    An installation in a Federal building tested the effectiveness of a highly-controlled, workstation-specific lighting retrofit. The study took place in an open-office area with 86 cubicles and low levels of daylight. Each cubicle was illuminated by a direct/indirectpendant luminaire with three 32 watt lamps, two dimmable DALI ballasts, and an occupancy sensor. A centralized control system programmed all three lamps to turn on and off according to occupancy on a workstation-by-workstation basis. Field measurements taken over the course of several monthsdemonstrated 40% lighting energy savings compared to a baseline without advanced controls that conforms to GSA's current retrofit standard. A photometric analysis found that the installation provided higher desktop light levels than the baseline, while an occupant survey found that occupants in general preferred the lighting system to thebaseline.Simple payback is fairly high; projects that can achieve lower installation costs and/or higher energy savings and those in which greenhouse gas reduction and occupant satisfaction are significant priorities provide the ideal setting for workstation-specific lighting retrofits.

  13. Academic attainment and the high school science experiences among high-achieving African American males

    NASA Astrophysics Data System (ADS)

    Trice, Rodney Nathaniel

    This study examines the educational experiences of high achieving African American males. More specifically, it analyzes the influences on their successful navigation through high school science. Through a series of interviews, observations, questionnaires, science portfolios, and review of existing data the researcher attempted to obtain a deeper understanding of high achieving African American males and their limitations to academic attainment and high school science experiences. The investigation is limited to ten high achieving African American male science students at Woodcrest High School. Woodcrest is situated at the cross section of a suburban and rural community located in the southeastern section of the United States. Although this investigation involves African American males, all of whom are successful in school, its findings should not be generalized to this nor any other group of students. The research question that guided this study is: What are the limitations to academic attainment and the high school science experiences of high achieving African American males? The student participants expose how suspension and expulsion, special education placement, academic tracking, science instruction, and teacher expectation influence academic achievement. The role parents play, student self-concept, peer relationships, and student learning styles are also analyzed. The anthology of data rendered three overarching themes: (1) unequal access to education, (2) maintenance of unfair educational structures, and (3) authentic characterizations of African American males. Often the policies and practices set in place by school officials aid in creating hurdles to academic achievement. These policies and practices are often formed without meaningful consideration of the unintended consequences that may affect different student populations, particularly the most vulnerable. The findings from this study expose that high achieving African American males face major

  14. Dominant Achievement Goals across Tracks in High School

    ERIC Educational Resources Information Center

    Scheltinga, Peter A. M.; Kuyper, Hans; Timmermans, Anneke C.; van der Werf, Greetje P. C.

    2016-01-01

    The dominant achievement goals (DAGs) of 7,008 students in the third grade of Dutch secondary education (US grade 9) were investigated, based on Elliot & McGregors' 2 × 2 framework (2001), in relation to track-level and motivational variables. We found the mastery-approach goal and the performance-approach goal, generally considered adaptive,…

  15. Charter High Schools: Closing the Achievement Gap. Innovations in Education

    ERIC Educational Resources Information Center

    US Department of Education, 2006

    2006-01-01

    The eight schools profiled in this document are serving different populations, but all of them are closing the achievement gap between low-income, minority, and special needs students and their peers. By trying out innovative new strategies, these schools are blazing a trail for others to follow. They are dispelling the myth that some students can…

  16. "Brains before "Beauty"?" High Achieving Girls, School and Gender Identities

    ERIC Educational Resources Information Center

    Skelton, Christine; Francis, Becky; Read, Barbara

    2010-01-01

    In recent years educational policy on gender and achievement has concentrated on boys' underachievement, frequently comparing it with the academic success of girls. This has encouraged a perception of girls as the "winners" of the educational stakes and assumes that they no longer experience the kinds of gender inequalities identified in…

  17. Parenting Style, Perfectionism, and Creativity in High-Ability and High-Achieving Young Adults

    ERIC Educational Resources Information Center

    Miller, Angie L.; Lambert, Amber D.; Speirs Neumeister, Kristie L.

    2012-01-01

    The current study explores the potential relationships among perceived parenting style, perfectionism, and creativity in a high-ability and high-achieving young adult population. Using data from 323 honors college students at a Midwestern university, bivariate correlations suggested positive relationships between (a) permissive parenting style and…

  18. Success Despite Socioeconomics: A Case Study of a High-Achieving, High-Poverty School

    ERIC Educational Resources Information Center

    Tilley, Thomas Brent; Smith, Samuel J.; Claxton, Russell L.

    2012-01-01

    This case study of a high-achieving, high-poverty school describes the school's leadership, culture, and programs that contributed to its success. Data were collected from two surveys (the School Culture Survey and the Vanderbilt Assessment of Leadership in Education), observations at the school site, and interviews with school personnel. The…

  19. Fragmentation and conformation study of ephedrine by low- and high-resolution mass selective UV spectroscopy

    NASA Astrophysics Data System (ADS)

    Chervenkov, S.; Wang, P. Q.; Braun, J. E.; Neusser, H. J.

    2004-10-01

    The neurotransmitter molecule, ephedrine, has been studied by mass-selective low- and high-resolution UV resonance enhanced two-photon ionization spectroscopy. Under all experimental conditions we observed an efficient fragmentation upon ionization. The detected vibronic peaks in the spectrum are classified according to the efficiency of the fragmentation, which leads to the conclusion that there exist three different species in the molecular beam: ephedrine-water cluster and two distinct conformers. The two-color two-photon ionization experiment with a decreased energy of the second photon leads to an upper limit of 8.3 eV for the ionization energy of ephedrine. The high-resolution (70 MHz) spectrum of the strongest vibronic peak in the spectrum measured at the fragment (m/z=58) mass channel displays a pronounced and rich rotational structure. Its analysis by the use of a specially designed computer-aided rotational fit process yields accurate rotational constants for the S0 and S1 states and the transition moment ratio, providing information on the respective conformational structure.

  20. Three-dimensional conformal graphene microstructure for flexible and highly sensitive electronic skin.

    PubMed

    Yang, Jun; Ran, Qincui; Wei, Dapeng; Sun, Tai; Yu, Leyong; Song, Xuefen; Pu, Lichun; Shi, Haofei; Du, Chunlei

    2017-03-17

    We demonstrate a highly stretchable electronic skin (E-skin) based on the facile combination of microstructured graphene nanowalls (GNWs) and a polydimethylsiloxane (PDMS) substrate. The microstructure of the GNWs was endowed by conformally growing them on the unpolished silicon wafer without the aid of nanofabrication technology. Then a stamping transfer method was used to replicate the micropattern of the unpolished silicon wafer. Due to the large contact interface between the 3D graphene network and the PDMS, this type of E-skin worked under a stretching ratio of nearly 100%, and showed excellent mechanical strength and high sensitivity, with a change in relative resistance of up to 6500% and a gauge factor of 65.9 at 99.64% strain. Furthermore, the E-skin exhibited an obvious highly sensitive response to joint movement, eye movement and sound vibration, demonstrating broad potential applications in healthcare, body monitoring and wearable devices.

  1. Three-dimensional conformal graphene microstructure for flexible and highly sensitive electronic skin

    NASA Astrophysics Data System (ADS)

    Yang, Jun; Ran, Qincui; Wei, Dapeng; Sun, Tai; Yu, Leyong; Song, Xuefen; Pu, Lichun; Shi, Haofei; Du, Chunlei

    2017-03-01

    We demonstrate a highly stretchable electronic skin (E-skin) based on the facile combination of microstructured graphene nanowalls (GNWs) and a polydimethylsiloxane (PDMS) substrate. The microstructure of the GNWs was endowed by conformally growing them on the unpolished silicon wafer without the aid of nanofabrication technology. Then a stamping transfer method was used to replicate the micropattern of the unpolished silicon wafer. Due to the large contact interface between the 3D graphene network and the PDMS, this type of E-skin worked under a stretching ratio of nearly 100%, and showed excellent mechanical strength and high sensitivity, with a change in relative resistance of up to 6500% and a gauge factor of 65.9 at 99.64% strain. Furthermore, the E-skin exhibited an obvious highly sensitive response to joint movement, eye movement and sound vibration, demonstrating broad potential applications in healthcare, body monitoring and wearable devices.

  2. Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural Database.

    PubMed

    Hawkins, Paul C D; Skillman, A Geoffrey; Warren, Gregory L; Ellingson, Benjamin A; Stahl, Matthew T

    2010-04-26

    Here, we present the algorithm and validation for OMEGA, a systematic, knowledge-based conformer generator. The algorithm consists of three phases: assembly of an initial 3D structure from a library of fragments; exhaustive enumeration of all rotatable torsions using values drawn from a knowledge-based list of angles, thereby generating a large set of conformations; and sampling of this set by geometric and energy criteria. Validation of conformer generators like OMEGA has often been undertaken by comparing computed conformer sets to experimental molecular conformations from crystallography, usually from the Protein Databank (PDB). Such an approach is fraught with difficulty due to the systematic problems with small molecule structures in the PDB. Methods are presented to identify a diverse set of small molecule structures from cocomplexes in the PDB that has maximal reliability. A challenging set of 197 high quality, carefully selected ligand structures from well-solved models was obtained using these methods. This set will provide a sound basis for comparison and validation of conformer generators in the future. Validation results from this set are compared to the results using structures of a set of druglike molecules extracted from the Cambridge Structural Database (CSD). OMEGA is found to perform very well in reproducing the crystallographic conformations from both these data sets using two complementary metrics of success.

  3. A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability

    PubMed Central

    Ding, Shilei; Tolbert, William D.; Prévost, Jérémie; Pacheco, Beatriz; Coutu, Mathieu; Debbeche, Olfa; Xiang, Shi-Hua

    2016-01-01

    ABSTRACT Previous studies have shown that highly conserved residues in the inner domain of gp120 are required for HIV-1 envelope glycoprotein (Env) transitions to the CD4-bound conformation (A. Finzi, S. H. Xiang, B. Pacheco, L. Wang, J. Haight, et al., Mol Cell 37:656–667, 2010, http://dx.doi.org/10.1016/j.molcel.2010.02.012; A. Desormeaux, M. Coutu, H. Medjahed, B. Pacheco, A. Herschhorn, et al., J Virol 87:2549–2562, 2013, http://dx.doi.org/10.1128/JVI.03104-12). Moreover, W69, a highly conserved residue located at the interface between layer 1 and layer 2 of the inner domain, was recently shown to be important for efficient Env recognition by CD4-induced (CD4i) antibodies capable of potent antibody-dependent cellular cytotoxicity (W. D. Tolbert, N. Gohain, M. Veillette, J. P. Chapleau, C. Orlandi, et al., 2016, Structure 24:697–709, http://dx.doi.org/10.1016/j.str.2016.03.005; S. Ding, M. Veillette, M. Coutu, J. Prevost, L. Scharf, et al., 2016, J Virol 90:2127–2134, http://dx.doi.org/10.1128/JVI.02779-15). We evaluated the contribution of the hydrophobicity of W69 to conformational changes of Env by replacing it with a series of residues with aliphatic or aromatic side chains of decreasing chain length. We have found that the hydrophobicity of residue 69 is important for Env processing, CD4 binding, and its transition to the CD4-bound conformation. The most deleterious effect was observed when W69 was replaced with alanine or glycine residues. However, the functions lost due to W69 mutations could be progressively restored with amino acids of increasing aliphatic chain length and fully recovered with residues bearing an aromatic ring. Interestingly, poor CD4 binding of W69A could be fully restored by introducing a compensatory mutation within layer 2 (S115W). Structural studies of HIV-1 gp120 coree W69A/S115W mutant bound to the CD4 peptide mimetic M48U1 and Fab of anti-cluster A antibody N60-i3 revealed no perturbations to the overall structure of the

  4. A nanofiber based artificial electronic skin with high pressure sensitivity and 3D conformability

    NASA Astrophysics Data System (ADS)

    Zhong, Weibin; Liu, Qiongzhen; Wu, Yongzhi; Wang, Yuedan; Qing, Xing; Li, Mufang; Liu, Ke; Wang, Wenwen; Wang, Dong

    2016-06-01

    Pressure sensors with 3D conformability are highly desirable components for artificial electronic skin or e-textiles that can mimic natural skin, especially for application in real-time monitoring of human physiological signals. Here, a nanofiber based electronic skin with ultra-high pressure sensitivity and 3D conformability is designed and built by interlocking two elastic patterned nanofibrous membranes. The patterned membrane is facilely prepared by casting conductive nanofiber ink into a silicon mould to form an array of semi-spheroid-like protuberances. The protuberances composed of intertwined elastic POE nanofibers and PPy@PVA-co-PE nanofibers afford a tunable effective elastic modulus that is capable of capturing varied strains and stresses, thereby contributing to a high sensitivity for pressure sensing. This electronic skin-like sensor demonstrates an ultra-high sensitivity (1.24 kPa-1) below 150 Pa with a detection limit as low as about 1.3 Pa. The pixelated sensor array and a RGB-LED light are then assembled into a circuit and show a feasibility for visual detection of spatial pressure. Furthermore, a nanofiber based proof-of-concept wireless pressure sensor with a bluetooth module as a signal transmitter is proposed and has demonstrated great promise for wireless monitoring of human physiological signals, indicating a potential for large scale wearable electronic devices or e-skin.Pressure sensors with 3D conformability are highly desirable components for artificial electronic skin or e-textiles that can mimic natural skin, especially for application in real-time monitoring of human physiological signals. Here, a nanofiber based electronic skin with ultra-high pressure sensitivity and 3D conformability is designed and built by interlocking two elastic patterned nanofibrous membranes. The patterned membrane is facilely prepared by casting conductive nanofiber ink into a silicon mould to form an array of semi-spheroid-like protuberances. The

  5. “A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide”

    PubMed Central

    Thota, Chaitanya Kumar; Yadav, Nitin; Chauhan, Virander Singh

    2016-01-01

    Nanostructures including hydrogels based on peptides containing non protein amino acids are being considered as platform for drug delivery because of their inherent biocompatibility and additional proteolytic stability. Here we describe instantaneous self-assembly of a conformationally restricted dipeptide, LeuΔPhe, containing an α,β-dehydrophenylalanine residue into a highly stable and mechanically strong hydrogel, under mild physiological aqueous conditions. The gel successfully entrapped several hydrophobic and hydrophilic drug molecules and released them in a controlled manner. LeuΔPhe was highly biocompatible and easily injectable. Administration of an antineoplastic drug entrapped in the gel in tumor bearing mice significantly controlled growth of tumors. These characteristics make LeuΔPhe an attractive candidate for further development as a delivery platform for various biomedical applications. PMID:27507432

  6. The Relationship between Self-Esteem and Academic Achievement in a Group of High, Medium, and Low Secondary Public High School Achievers.

    ERIC Educational Resources Information Center

    Thomas-Brantley, Betty J.

    This study investigated the relationship between self-esteem and academic achievement in a group of 150 high, medium, and low achievers at a large midwestern public high school. Correlating data from the Coopersmith Inventory of self-esteem with grades, cumulative grade point averages, and class rank, the study disclosed a positive correlation…

  7. Effect of Concurrent High-Dose Cisplatin Chemotherapy and Conformal Radiotherapy on Cervical Esophageal Cancer Survival

    SciTech Connect

    Huang Shaohui; Lockwood, Gina; Brierley, James; Cummings, Bernard; Kim, John; Wong, Rebecca; Bayley, Andrew; Ringash, Jolie

    2008-07-01

    Purpose: To determine whether a change in treatment policy to conformal, elective nodal radiotherapy and concurrent high-dose cisplatin improved survival for cervical esophageal cancer patients. Methods and Materials: All cervical esophageal cancer patients treated between 1997 and 2005 were restaged (1983 American Joint Committee on Cancer criteria). Patients treated before 2001 (previous cohort [PC]) were compared with those treated from 2001 onward (recent cohort [RC]). The PC institutional chemoradiotherapy protocol was 54 Gy in 20 fractions within 4 weeks, with 5-fluorouracil (1,000 mg/m{sup 2}) on Days 1-4 and either mitomycin C (10 mg/m{sup 2}) or cisplatin (75 mg/m{sup 2}) on Day 1. The RC institutional chemoradiotherapy protocol was conformal radiotherapy, 70 Gy in 35 fractions within 7 weeks, to the primary tumor and elective nodes, with high-dose cisplatin (100 mg/m{sup 2}) on Days 1, 22, and 43. Results: The median follow-up was 3.1 years (PC, 8.1 and RC, 2.3). Of 71 patients (25 women and 46 men), 21 of 29 in the PC and 29 of 42 in the RC were treated curatively (curative subgroup, n = 50). Between the two groups, no differences in overall survival or locoregional relapse-free survival were seen. The overall survival rate at 2 and 5 years was 35% (range, 24-47%) and 21% (range, 12-32%) in the whole group and 46% (range 32-60%) and 28% (range, 15-42%) in the curative group, respectively. In the curative group, no statistically significant prognostic factors were found. Trends toward better locoregional relapse-free survival were seen in women (2-year rate, 73% vs. for men, 36%; p = 0.08) and in patients aged >64 years (2-year rate, 68% vs. age {<=}64 years, 34%; p = 0.10). Conclusion: No survival improvement could be demonstrated after changing the treatment policy to high-dose cisplatin-based, conventionally fractionated conformal chemoradiotherapy. Female gender and older age might predict for better outcomes.

  8. High resolution ion mobility measurements for gas phase proteins: correlation between solution phase and gas phase conformations

    NASA Astrophysics Data System (ADS)

    Hudgins, Robert R.; Woenckhaus, Jürgen; Jarrold, Martin F.

    1997-11-01

    Our high resolution ion mobility apparatus has been modified by attaching an electrospray source to perform measurements for biological molecules. While the greater resolving power permits the resolution of more conformations for BPTI and cytochrome c, the resolved features are generally much broader than expected for a single rigid conformation. A major advantage of the new experimental configuration is the much gentler introduction of ions into the drift tube, so that the observed gas phase conformations appear to more closely reflect those present in solution. For example, it is possible to distinguish between the native state of cytochrome c and the methanol-denatured form on the basis of the ion mobility measurements; the mass spectra alone are not sensitive enough to detect this change. Thus this approach may provide a quick and sensitive tool for probing the solution phase conformations of biological molecules.

  9. Relationships among Stress, Coping, and Mental Health in High-Achieving High School Students

    ERIC Educational Resources Information Center

    Suldo, Shannon M.; Shaunessy, Elizabeth; Hardesty, Robin

    2008-01-01

    This study investigates the relationships among stress, coping, and mental health in 139 students participating in an International Baccalaureate (IB) high school diploma program. Mental health was assessed using both positive indicators (life satisfaction, academic achievement, academic self-efficacy) and negative indicators (psychopathology) of…

  10. Examining Organizational Practices That Predict Persistence among High-Achieving Black Males in High School

    ERIC Educational Resources Information Center

    Anderson, Kenneth Alonzo

    2016-01-01

    Background/Context: This article summarizes an increasing trend of antideficit Black male research in mathematics and highlights opportunities to add to the research. A review of the literature shows that antideficit researchers often examine relationships between individual traits and persistence of high-achieving Black males in mathematics.…

  11. The Strengths of High-Achieving Black High School Students in a Racially Diverse Setting

    ERIC Educational Resources Information Center

    Marsh, Kris; Chaney, Cassandra; Jones, Derrick

    2012-01-01

    Robert Hill (1972) identified strengths of Black families: strong kinship bonds, strong work orientation, adaptability of family roles, high achievement orientation, and religious orientation. Some suggest these strengths sustain the physical, emotional, social, and spiritual needs of Blacks. This study used narratives and survey data from a…

  12. Relationship between High School Mathematical Achievement and Quantitative GPA

    ERIC Educational Resources Information Center

    Brown, Jennifer L.; Halpin, Glennelle; Halpin, Gerald

    2015-01-01

    The demand for STEM graduates has increased, but the number of incoming freshmen who declare a STEM major has remained stagnant. High school courses, such as calculus, can open or close the gate for students interested in careers in STEM. The purpose of this study was to determine if high school mathematics preparation was a significant…

  13. Postoperative Chemotherapy Followed by Conformal Concomitant Chemoradiotherapy in High-Risk Gastric Cancer

    SciTech Connect

    Quero, Laurent; Bouchbika, Zineb; Kouto, Honorine; Baruch-Hennequin, Valerie; Gornet, Jean-Marc; Munoz, Nicolas; Cojean-Zelek, Isabelle; Houdart, Remi; Panis, Yves; Valleur, Patrice; Aparicio, Thomas; Maylin, Claude; Hennequin, Christophe

    2012-06-01

    Purpose: To analyze the efficacy, toxicity, and pattern of relapse after adjuvant cisplatin-based chemotherapy followed by three-dimensional irradiation and concomitant LV5FU2 chemotherapy (high-dose leucovorin and 5-fluorouracil bolus plus continuous infusion) in the treatment of completely resected high-risk gastric cancer. Methods and Materials: This was a retrospective analysis of 52 patients with high-risk gastric cancer initially treated by total/partial gastrectomy and lymphadenectomy between January 2002 and June 2007. Median age was 54 years (range, 36-75 years). Postoperative treatment consisted of 5-fluorouracil and cisplatin chemotherapy. Adjuvant chemotherapy was followed by three-dimensional conformal radiotherapy in the tumor bed and regional lymph nodes at 4500 cGy/25 fractions in association with concomitant chemotherapy. Concomitant chemotherapy consisted of a 2-h infusion of leucovorin (200 mg/m Superscript-Two ) followed by a bolus of 5-fluorouracil (400 mg/m Superscript-Two ) and then a 44-h continuous infusion of 5-fluorouracil (2400-3600 mg/m Superscript-Two ) given every 14 days, for three cycles (LV5FU2 protocol). Results: Five-year overall and disease-free survival were 50% and 48%, respectively. Distant metastases and peritoneal spread were the most frequent sites of relapse (37% each). After multivariate analysis, only pathologic nodal status was significantly associated with disease-free and overall survival. Acute toxicities were essentially gastrointestinal and hematologic. One myocardial infarction and one pulmonary embolism were also reported. Eighteen patients had a radiotherapy program interruption because of acute toxicity. All patients but 2 have completed radiotherapy. Conclusion: Postoperative cisplatin-based chemotherapy followed by conformal radiotherapy in association with concurrent 5-fluorouracil seemed to be feasible and resulted in successful locoregional control.

  14. Practically Perfect in Every Way: Can Reframing Perfectionism for High-Achieving Undergraduates Impact Academic Resilience?

    ERIC Educational Resources Information Center

    Dickinson, Mary J.; Dickinson, David A. G.

    2015-01-01

    This study focuses on a pan-disciplinary scheme that targeted high-achieving undergraduate students. Earlier research from the scheme argued that high achievers have discernibly different learning and personal development support needs. One of the most frequent self-reported challenges within this high-achieving group is perfectionism. This…

  15. High Achiever: A School Modernization Uncovers Hidden Potential.

    ERIC Educational Resources Information Center

    Babcock, Regina Raiford

    2003-01-01

    Describes the renovation of Lisle Senior High School in Lisle, Illinois, including the educational context and design goals. Includes information on the architects, suppliers, and construction team. Also includes the floor plan and photographs. (EV)

  16. Intrinsically disordered protein from a pathogenic mesophile Mycobacterium tuberculosis adopts structured conformation at high temperature.

    PubMed

    Kumar, Niti; Shukla, Swati; Kumar, Sanjiv; Suryawanshi, Anju; Chaudhry, Uma; Ramachandran, Srinivasan; Maiti, Souvik

    2008-05-15

    Compared to eukaryotes, the occurrence of "intrinsically disordered" or "natively unfolded" proteins in prokaryotes has not been explored extensively. Here, we report the occurrence of an intrinsically disordered protein from the mesophilic human pathogen Mycobacterium tuberculosis. The Histidine-tagged recombinant Rv3221c biotin-binding protein is intrinsically disordered at ambient and physiological growth temperatures as revealed by circular dichroism and Fourier transform infrared (FTIR) spectroscopic studies. However, an increase in temperature induces a transition from disordered to structured state with a folding temperature of approximately 53 degrees C. Addition of a structure inducing solvent trifluoroethanol (TFE) causes the protein to fold at lower temperatures suggesting that TFE fosters hydrophobic interactions, which drives protein folding. Differential Scanning Calorimetry studies revealed that folding is endothermic and the transition from a disordered to structured state is continuous (higher-order), implying existence of intermediates during folding process. Secondary structure analysis revealed that the protein has propensity to form beta-sheets. This is in conformity with FTIR spectrum that showed an absorption peak at wave number of 1636 cm(-1), indicative of disordered beta-sheet conformation in the native state. These data suggest that although Rv3221c may be disordered under ambient or optimal growth temperature conditions, it has the potential to fold into ordered structure at high temperature driven by increased hydrophobic interactions. In contrast to the generally known behavior of other intrinsically disordered proteins folding at high temperature, Rv3221c does not appear to oligomerize or aggregate as revealed through numerous experiments including Congo red binding, Thioflavin T-binding, turbidity measurements, and examining molar ellipticity as a function of protein concentration. The amino acid composition of Rv3221c reveals that

  17. Gender, Student Motivation and Academic Achievement in a Midsized Wisconsin High School

    ERIC Educational Resources Information Center

    Lutzke, Steven Ronald

    2013-01-01

    This mixed-methods study investigated relationships among gender, academic motivation and achievement in a mid-sized Wisconsin high school. A questionnaire was developed that focused on perceived ability, achievement motives and achievement goals. Interviews with teachers focused on relationships among academic motivation and gender achievement.…

  18. Student Achievement Data Systems in High and Low Performing Schools

    ERIC Educational Resources Information Center

    Stachowiak, Jeannie E.

    2013-01-01

    The purpose of this study was to determine if there was a difference in how high and low performing elementary school districts use and analyze data to differentiate instruction, make changes to district/grade level curriculum, determine professional development needs, determine teacher effectiveness, and determine the use of school district…

  19. Behaviour and achievement disorders in children with high intelligence.

    PubMed

    Barchmann, H; Kinze, W

    1990-01-01

    With 6% of the patients of a childpsychiatric population using treatment a high intelligence with an IQ of over 120 was the result. This is in agreement with the results by Reinhard (1981), but is below the results by Schmidt (1977) and justifies neither the association to a higher talent as risk factor nor as protective factor in view of a potential psychic illness. 341 child-neuropsychiatric patients with hyperkinetic syndrome (55%), Enuresis (28%), reactions of adaptation (5%), specific emotional disturbances in childhood (4%), Encopresis (3%), Psychalgy (3%) and tics (2%) were studied; thereby 22 highly intelligent patients were compared with average intelligent patients. With high intelligence better performances of concentration, more reflexive style of study, better school notes and more favourable motor capabilities, less pronounced signs of anxiety and neuroticism are found, but also a poorer social adaptation and less favourable effects of treatment. Concerning the poorer chances of treatment with high intelligence however the behaviour-therapeutic concentration of our therapy has to be pointed out, which might not offer an optimal chance for development.

  20. Organizational Citizenship of Faculty and Achievement of High School Students

    ERIC Educational Resources Information Center

    DiPaola, Michael F.; Hoy, Wayne K.

    2005-01-01

    All successful organizations, including successful high schools, have employees who go beyond their formal job responsibilities and freely give of their time and energy to succeed. Organ was the first to use the phrase "organizational citizenship behavior" (OCB) to denote organizationally beneficial behavior of workers that was not prescribed but…

  1. Common Core and America's High-Achieving Students

    ERIC Educational Resources Information Center

    Plucker, Jonathan A.

    2015-01-01

    While the merit and politics of the Common Core State Standards (CCSS) have been much debated and discussed, one topic has been virtually ignored: What do the standards portend for America's high-ability students? This brief addresses that question and provides guidance for CCSS-implementing districts and schools as they seek to help these…

  2. Syllabication Skills and Reading Achievement of High School Students.

    ERIC Educational Resources Information Center

    Curry, Robert L.; Geis, Lynna

    A sample of 175 students, constituting grades 10, 11, and 12 of two high schools, was used in the validation of a new Syllabication Skills Test. On the first day, the students completed four forms of the syllabication test; on the second, they completed Survey F of the Gates-MacGinitie Reading Tests. Means and standard deviations were similar for…

  3. Technology's Achilles Heel: Achieving High-Quality Implementation

    ERIC Educational Resources Information Center

    Hall, Gene E.

    2010-01-01

    An inherent characteristic of technology education is the continual development of new technologies and creating innovative applications of already existing technologies. As exciting as these innovations can be, technology educators and school staffs are frequently challenged to accomplish high levels of implementation. The metaphor of the…

  4. Alternative High School Scheduling. Student Achievement and Behavior. Research Report.

    ERIC Educational Resources Information Center

    Pisapia, John; Westfall, Amy Lynn

    In 1995 the Metropolitan Educational Research Consortium (MERC), Richmond (Virginia) commissioned a study of alternative high school scheduling modules to determine the effects of different schedules on teaching strategies, teacher and student satisfaction, and student and school performance. This report presents results of an analysis of student…

  5. High-Achieving Schools Put Equity Front and Center

    ERIC Educational Resources Information Center

    Gleason, Sonia Caus; Gerzon, Nancy

    2014-01-01

    How does professional learning look and feel in high-poverty schools where every student makes at least one year's worth of progress every year? How do schools and leaders put all the varied components of professional learning together so that they support all students learning every day? What professional learning grounds and sustains educators…

  6. More High-Achieving Students Are Choosing Community Colleges First

    ERIC Educational Resources Information Center

    Pluviose, David

    2008-01-01

    Certainly, "Tonight Show" host Jay Leno has nurtured the perception that community colleges are a punishment for underperforming high school students by joking that community colleges aren't "real colleges." This article shows that this perception belies the reality that contemporary community colleges serve students seeking trade skills but also…

  7. Impact of learning orientation on African American children's attitudes toward high-achieving peers.

    PubMed

    Marryshow, Derrick; Hurley, Eric A; Allen, Brenda A; Tyler, Kenneth M; Boykin, A Wade

    2005-01-01

    This study examined Ogbu's widely accepted thesis that African American students reject high academic achievement because they perceive its limited utility in a world where their upward mobility is constrained by racial discrimination. Boykin's psychosocial integrity model contends that Black students value high achievement but that discrepancies between their formative cultural experiences and those imposed in school lead them to reject the modes of achievement available in classrooms. Ninety Black children completed a measure of attitudes toward students who achieve via mainstream or African American cultural values. Participants rejected the mainstream achievers and embraced the African American cultural achievers. Moreover, they expected their teachers to embrace the mainstream achievers and reject those who achieved through high-verve behavior. Results suggest that Boykin's thesis is a needed refinement to Ogbu's ideas. They indicate that Black children may reject not high achievement but some of the mainstream cultural values and behaviors on which success in mainstream classrooms is made contingent.

  8. Achieving High Reliability Operations Through Multi-Program Integration

    SciTech Connect

    Holly M. Ashley; Ronald K. Farris; Robert E. Richards

    2009-04-01

    Over the last 20 years the Idaho National Laboratory (INL) has adopted a number of operations and safety-related programs which has each periodically taken its turn in the limelight. As new programs have come along there has been natural competition for resources, focus and commitment. In the last few years, the INL has made real progress in integrating all these programs and are starting to realize important synergies. Contributing to this integration are both collaborative individuals and an emerging shared vision and goal of the INL fully maturing in its high reliability operations. This goal is so powerful because the concept of high reliability operations (and the resulting organizations) is a masterful amalgam and orchestrator of the best of all the participating programs (i.e. conduct of operations, behavior based safety, human performance, voluntary protection, quality assurance, and integrated safety management). This paper is a brief recounting of the lessons learned, thus far, at the INL in bringing previously competing programs into harmony under the goal (umbrella) of seeking to perform regularly as a high reliability organization. In addition to a brief diagram-illustrated historical review, the authors will share the INL’s primary successes (things already effectively stopped or started) and the gaps yet to be bridged.

  9. Telescoping Solar Array Concept for Achieving High Packaging Efficiency

    NASA Technical Reports Server (NTRS)

    Mikulas, Martin; Pappa, Richard; Warren, Jay; Rose, Geoff

    2015-01-01

    Lightweight, high-efficiency solar arrays are required for future deep space missions using high-power Solar Electric Propulsion (SEP). Structural performance metrics for state-of-the art 30-50 kW flexible blanket arrays recently demonstrated in ground tests are approximately 40 kW/cu m packaging efficiency, 150 W/kg specific power, 0.1 Hz deployed stiffness, and 0.2 g deployed strength. Much larger arrays with up to a megawatt or more of power and improved packaging and specific power are of interest to mission planners for minimizing launch and life cycle costs of Mars exploration. A new concept referred to as the Compact Telescoping Array (CTA) with 60 kW/cu m packaging efficiency at 1 MW of power is described herein. Performance metrics as a function of array size and corresponding power level are derived analytically and validated by finite element analysis. Feasible CTA packaging and deployment approaches are also described. The CTA was developed, in part, to serve as a NASA reference solar array concept against which other proposed designs of 50-1000 kW arrays for future high-power SEP missions could be compared.

  10. From Dropout to High Achiever: An Understanding of Academic Excellence through the Ethnography of High and Low Achieving Secondary School Students.

    ERIC Educational Resources Information Center

    Cuellar, Alfredo

    This paper, a follow-up to a previous review of literature on academic excellence that synthesized information from the United States and Mexico, describes an ethnographic study of high-achieving and low-achieving Hispanic secondary school students from Calexico, California and Mexicali, Baja California Mexico. Five students for each group were…

  11. Achieving high data reduction with integral cubic B-splines

    NASA Technical Reports Server (NTRS)

    Chou, Jin J.

    1993-01-01

    During geometry processing, tangent directions at the data points are frequently readily available from the computation process that generates the points. It is desirable to utilize this information to improve the accuracy of curve fitting and to improve data reduction. This paper presents a curve fitting method which utilizes both position and tangent direction data. This method produces G(exp 1) non-rational B-spline curves. From the examples, the method demonstrates very good data reduction rates while maintaining high accuracy in both position and tangent direction.

  12. High Achievement in Mathematics Education in India: A Report from Mumbai

    ERIC Educational Resources Information Center

    Raman, Manya

    2010-01-01

    This paper reports a study aimed at characterizing the conditions that lead to high achievement in mathematics in India. The study involved eight schools in the greater Mumbai region. The main result of the study is that the notion of high achievement itself is problematic, as reflected in the reports about mathematics achievement within and…

  13. Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.

    PubMed Central

    Pelton, J T; Gulya, K; Hruby, V J; Duckles, S P; Yamamura, H I

    1985-01-01

    A series of cyclic, conformationally restricted analogs of somatostatin have been prepared and tested for their ability to inhibit the binding of [3H]naloxone and [D-Ala2, D-Leu5] [3H]enkephalin to rat brain membranes. The most potent analog, D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 where Pen is penicillamine in [D-Phe5, Cys6, Tyr7, D-Trp8, Pen11]somatostatin-(5-12)-octapeptide amide, exhibited high affinity for mu-opiate receptors (IC50 value of [3H]naloxone = 3.5 nM), being 7800 times more potent than somatostatin. The cyclic octapeptide also displayed high mu-opiate receptor selectivity with an IC50 [( D-Ala2,D-Leu5]enkephalin)/IC50 (naloxone) ratio of 271. The high affinity and selectivity of the somatostatin analog for mu-opiate receptors may be of use in examining the physiological role(s) of the mu-opiate receptor. PMID:2857488

  14. Highly Conformal Ni Micromesh as a Current Collecting Front Electrode for Reduced Cost Si Solar Cell.

    PubMed

    Gupta, Nikita; Rao, K D M; Gupta, Ritu; Krebs, Frederik C; Kulkarni, Giridhar U

    2017-02-28

    Despite relatively high manufacturing cost, crystalline-Si solar cell continues to hold promising future due to its high energy conversion efficiency and long life. As regards cost, one pertinent issue is the top electrode metallization of textured cell surface, which typically involves screen printing of silver paste. The associated disadvantages call for alternative methods that can lower the cost without compromising the solar cell efficiency. In the present work, a highly interconnected one-dimensional (1D) metal wire network has been employed as front electrode on conventional Si wafers. Here, for the first time, we report an innovative solution based crackle templating method for conformal metal wire network patterning over large textured surfaces. Laser beam induced current mapping showed uniform photocurrent collection by the electrodes without any shadow losses. With electroless deposition of Ni wire network on corrugated solar cell, a short circuit current of 33.28 mA/cm(2) was obtained in comparison to 20.53 mA/cm(2) without the network electrode. On comparing the efficiency with the conventional cells with screen printed electrodes, a 20% increment in efficiency has been observed. Importantly, the estimated manufacturing cost is at least two orders lower.

  15. Rectangular Dielectric-loaded Structures for Achieving High Acceleration Gradients

    NASA Astrophysics Data System (ADS)

    Wang, Changbiao; Yakovlev, V. P.; Marshall, T. C.; LaPointe, M. A.; Hirshfield, J. L.

    2006-11-01

    Rectangular dielectric-loaded structures are described that may sustain higher acceleration gradients than conventional all-metal structures with similar apertures. One structure is a test cavity designed to ascertain the breakdown limits of dielectrics, while a second structure could be the basis for a two-beam accelerator. CVD diamond is an attractive dielectric for a high-gradient structure, since the published DC breakdown limit for CVD diamond is ˜ 2 GV/m, although the limit has never been determined for RF fields. Here we present a design of a diamond-lined test cavity to measure the breakdown limit. The designed cavity operates at 34 GHz, where with 10-MW input power it is expected to produce an ˜800 MV/m field on the diamond surface—provided breakdown is avoided. The two channel rectangular dielectric-loaded waveguide could be a two-beam accelerator structure, in which a drive beam is in one channel and an accelerated beam is in the other. The RF power produced by drive bunches in the drive channel is continuously coupled to the acceleration channel. The ratio of fields in the channels (transformer ratio) for the operating mode can be designed by adjusting the dimensions of the structure. An example of the two-channel structure is described, in which a train of five 3-nC drive bunches excites wake fields in the accelerator channel of up to 1.3 GV/m with a transformer ratio of 10 for the design mode.

  16. Soft, conformable electrical contacts for organic semiconductors: High-resolution plastic circuits by lamination

    PubMed Central

    Loo, Yueh-Lin; Someya, Takao; Baldwin, Kirk W.; Bao, Zhenan; Ho, Peter; Dodabalapur, Ananth; Katz, Howard E.; Rogers, John A.

    2002-01-01

    Soft, conformable electrical contacts provide efficient, noninvasive probes for the transport properties of chemically and mechanically fragile, ultrathin organic semiconducting films. When combined with high-resolution printing and lamination techniques, these soft contacts also form the basis of a powerful technique for fabricating flexible plastic circuits. In this approach, a thin elastomeric film on a plastic substrate supports the electrodes and interconnections; laminating this substrate against another plastic substrate that supports the gate, dielectric and semiconductor levels establishes effective electrical contacts and completes the circuits. In addition to eliminating many of the problems associated with traditional layer-by-layer fabrication strategies, this lamination scheme possesses other attractive features: the transistors and circuit elements are naturally and efficiently encapsulated, and the active organic semiconductor layer is placed near the neutral mechanical plane. We demonstrate the features of soft, laminated contacts by fabricating large arrays of high-performance thin film transistors on plastic substrates by using a wide variety of organic semiconductors. PMID:12145323

  17. High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation.

    PubMed

    Azzu, Vian; Parker, Nadeene; Brand, Martin D

    2008-07-15

    Mitochondria generate reactive oxygen species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the uncoupling proteins and adenine nucleotide translocase. Using mitochondria from rat liver, which lack uncoupling proteins, in the present study we show that energization (specifically, high membrane potential) is required for 4-hydroxynonenal to activate proton conductance mediated by adenine nucleotide translocase. Prolonging the time at high membrane potential promotes greater uncoupling. 4-Hydroxynonenal-induced uncoupling via adenine nucleotide translocase is prevented but not readily reversed by addition of carboxyatractylate, suggesting a permanent change (such as adduct formation) that renders the translocase leaky to protons. In contrast with the irreversibility of proton conductance, carboxyatractylate added after 4-hydroxynonenal still inhibits nucleotide translocation, implying that the proton conductance and nucleotide translocation pathways are different. We propose a model to relate adenine nucleotide translocase conformation to proton conductance in the presence or absence of 4-hydroxynonenal and/or carboxyatractylate.

  18. "This Was My Hell": The Violence Experienced by Gender Non-Conforming Youth in US High Schools

    ERIC Educational Resources Information Center

    Wyss, Shannon E.

    2004-01-01

    This paper explores the experiences of harassment and violence endured by seven gender non-conforming youth in US high schools. Based on a larger research project, it opens an inquiry into the school-based lives of gender-variant teens, a group heretofore ignored by most academics and educators. Breaking violence down into two main types (physical…

  19. Formal Operational Precocity and Achievement in Biology among Some Nigerian High School Students.

    ERIC Educational Resources Information Center

    Ehindero, Olusola Joseph

    1979-01-01

    Compares the performances on a battery of six Piagetian tasks of 80 Nigerian high school students classified as high and low achievers in biology. The relationship between performance of very bright biology students (high achievers) and intellectual precocity is also investigated. (HM)

  20. The Chinese High School Student's Stress in the School and Academic Achievement

    ERIC Educational Resources Information Center

    Liu, Yangyang; Lu, Zuhong

    2011-01-01

    In a sample of 466 Chinese high school students, we examined the relationships between Chinese high school students' stress in the school and their academic achievements. Regression mixture modelling identified two different classes of the effects of Chinese high school students' stress on their academic achievements. One class contained 87% of…

  1. Beyond Academic Reputation: Factors that Influence the College of First Choice for High Achieving Students

    ERIC Educational Resources Information Center

    Schoenherr, Holly J.

    2009-01-01

    Studies that have investigated college choice factors for high-achieving students repeatedly cite academic reputation as one of the top indicators of choice but have not indicated why some high-achieving students choose to attend universities with a less prestigious reputation than the more highly prestigious options available to them. The purpose…

  2. Does High School Facility Quality Affect Student Achievement? A Two-Level Hierarchical Linear Model

    ERIC Educational Resources Information Center

    Bowers, Alex J.; Urick, Angela

    2011-01-01

    The purpose of this study is to isolate the independent effects of high school facility quality on student achievement using a large, nationally representative U.S. database of student achievement and school facility quality. Prior research on linking school facility quality to student achievement has been mixed. Studies that relate overall…

  3. The Effects of Web-Based/Non-Web-Based Problem-Solving Instruction and High/Low Achievement on Students' Problem-Solving Ability and Biology Achievement

    ERIC Educational Resources Information Center

    Yu, Wen-Feng; She, Hsiao-Ching; Lee, Yu-Mei

    2010-01-01

    This study investigates the effects of two factors: the mode of problem-solving instruction (i.e. Web-based versus non-Web-based) and the level of academic achievement (i.e. high achievers versus low achievers) on students' problem-solving ability and biology achievement. A quasi-experimental design was used, in which the experimental group…

  4. Spin pair geometry revealed by high-field DEER in the presence of conformational distributions

    NASA Astrophysics Data System (ADS)

    Polyhach, Ye.; Godt, A.; Bauer, C.; Jeschke, G.

    2007-03-01

    Orientation selection on two nitroxide-labelled shape-persistent molecules is demonstrated by high-field pulsed electron-electron double resonance experiments at a frequency of 95 GHz with a commercial spectrometer. The experiments are performed with fixed observer and pump frequencies by variation of the magnetic field, so that the variation of both the dipolar frequencies and the modulation depths can be analyzed. By applying the deadtime-free four-pulse double electron-electron resonance (DEER) sequence, the lineshapes of the dipolar spectra are obtained. In the investigated linear biradical and equilateral triradical the nitroxide labels undergo restricted dynamics, so that their relative orientations are not fixed, but are correlated to some extent. In this situation, the general dependence of the dipolar spectra on the observer field can be satisfyingly modelled by simple geometrical models that involve only one rotational degree of freedom for the biradical and two rotational degrees of freedom for the triradical. A somewhat better agreement of the dipolar lineshapes for the biradical is obtained by simulations based on a molecular dynamics trajectory. For the triradical, small but significant deviations of the lineshape are observed with both models, indicating that the technique can reveal deficiencies in modelling of the conformational ensemble of a macromolecule.

  5. Conformation-dependent high-affinity potent ricin-neutralizing monoclonal antibodies.

    PubMed

    Hu, Wei-Gang; Yin, Junfei; Chau, Damon; Hu, Charles Chen; Lillico, Dustin; Yu, Justin; Negrych, Laurel M; Cherwonogrodzky, John W

    2013-01-01

    Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conformational epitopes of ricin toxin B (RTB) with high affinity (KD values from 2.55 to 36.27 nM). RTB not only triggers cellular uptake of ricin, but also facilitates transport of the ricin toxin A (RTA) from the endoplasmic reticulum to the cytosol, where RTA exerts its toxic activity. The four mAbs were found to have potent ricin-neutralizing capacities and synergistic effects among them as determined by an in vitro neutralization assay. In vivo protection assay demonstrated that all four mAbs had strong efficacy against ricin challenges. D9 was found to be exceptionally effective. Intraperitoneal (i.p.) administration of D9, at a dose of 5 μ g, 6 weeks before or 6 hours after an i.p. challenge with 5 × LD50 of ricin was able to protect or rescue 100% of the mice, indicating that mAb D9 is an excellent candidate to be developed as a potent antidote against ricin poisoning for both prophylactic and therapeutic purposes.

  6. Conformation-Dependent High-Affinity Potent Ricin-Neutralizing Monoclonal Antibodies

    PubMed Central

    Hu, Wei-Gang; Yin, Junfei; Chau, Damon; Hu, Charles Chen; Lillico, Dustin; Yu, Justin; Negrych, Laurel M.; Cherwonogrodzky, John W.

    2013-01-01

    Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conformational epitopes of ricin toxin B (RTB) with high affinity (KD values from 2.55 to 36.27 nM). RTB not only triggers cellular uptake of ricin, but also facilitates transport of the ricin toxin A (RTA) from the endoplasmic reticulum to the cytosol, where RTA exerts its toxic activity. The four mAbs were found to have potent ricin-neutralizing capacities and synergistic effects among them as determined by an in vitro neutralization assay. In vivo protection assay demonstrated that all four mAbs had strong efficacy against ricin challenges. D9 was found to be exceptionally effective. Intraperitoneal (i.p.) administration of D9, at a dose of 5 μg, 6 weeks before or 6 hours after an i.p. challenge with 5 × LD50 of ricin was able to protect or rescue 100% of the mice, indicating that mAb D9 is an excellent candidate to be developed as a potent antidote against ricin poisoning for both prophylactic and therapeutic purposes. PMID:23484120

  7. Achieving High Strength and High Ductility in Friction Stir-Processed Cast Magnesium Alloy

    NASA Astrophysics Data System (ADS)

    Yuan, Wei; Panigrahi, Sushanta K.; Mishra, Rajiv S.

    2013-08-01

    Friction stir processing (FSP) is emerging as an effective tool for microstructural modification and property enhancement. As-cast AZ91 magnesium alloy was friction stir processed with one-pass and two-pass to examine the influence of processing conditions on microstructural evolution and corresponding mechanical properties. Grain refinement accompanied with development of strong basal texture was observed for both processing conditions. Ultrafine-grained (UFG) AZ91 was achieved under two-pass FSP with fine precipitates distributed on the grain boundary. The processed UFG AZ91 exhibited a high tensile strength of ~435 MPa (117 pct improvement) and tensile fracture elongation of ~23 pct. The promising combination of strength and ductility is attributed to the elimination of casting porosity, and high density of fine precipitates in an UFG structure with quite low dislocation density. The effects of grain size, precipitate, and texture on deformation behavior have been discussed.

  8. An Analysis of Java Programming Behaviors, Affect, Perceptions, and Syntax Errors among Low-Achieving, Average, and High-Achieving Novice Programmers

    ERIC Educational Resources Information Center

    Rodrigo, Ma. Mercedes T.; Andallaza, Thor Collin S.; Castro, Francisco Enrique Vicente G.; Armenta, Marc Lester V.; Dy, Thomas T.; Jadud, Matthew C.

    2013-01-01

    In this article we quantitatively and qualitatively analyze a sample of novice programmer compilation log data, exploring whether (or how) low-achieving, average, and high-achieving students vary in their grasp of these introductory concepts. High-achieving students self-reported having the easiest time learning the introductory programming…

  9. (13)CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins.

    PubMed

    Rennella, Enrico; Huang, Rui; Velyvis, Algirdas; Kay, Lewis E

    2015-10-01

    An NMR experiment for quantifying slow (millisecond) time-scale exchange processes involving the interconversion between visible ground state and invisible, conformationally excited state conformers is presented. The approach exploits chemical exchange saturation transfer (CEST) and makes use of (13)CHD2 methyl group probes that can be readily incorporated into otherwise highly deuterated proteins. The methodology is validated with an application to a G48A Fyn SH3 domain that exchanges between a folded conformation and a sparsely populated and transiently formed unfolded ensemble. Experiments on a number of different protein systems, including a 360 kDa half-proteasome, establish that the sensitivity of this (13)CHD2 (13)C-CEST technique can be upwards of a factor of 5 times higher than for a previously published (13)CH3 (13)C-CEST approach (Bouvignies and Kay in J Biomol NMR 53:303-310, 2012), suggesting that the methodology will be powerful for studies of conformational exchange in high molecular weight proteins.

  10. Conformer-specific hydrogen atom tunnelling in trifluoromethylhydroxycarbene

    NASA Astrophysics Data System (ADS)

    Mardyukov, Artur; Quanz, Henrik; Schreiner, Peter R.

    2017-01-01

    Conformational control of organic reactions is at the heart of the biomolecular sciences. To achieve a particular reactivity, one of many conformers may be selected, for instance, by a (bio)catalyst, as the geometrically most suited and appropriately reactive species. The equilibration of energetically close-lying conformers is typically assumed to be facile and less energetically taxing than the reaction under consideration itself: this is termed the 'Curtin-Hammett principle'. Here, we show that the trans conformer of trifluoromethylhydroxycarbene preferentially rearranges through a facile quantum-mechanical hydrogen tunnelling pathway, while its cis conformer is entirely unreactive. Hence, this presents the first example of a conformer-specific hydrogen tunnelling reaction. The Curtin-Hammett principle is not applicable, due to the high barrier between the two conformers.

  11. The Effect of the Time Management Art on Academic Achievement among High School Students in Jordan

    ERIC Educational Resources Information Center

    Al-Zoubi, Maysoon

    2016-01-01

    This study aimed at recognizing the effect of the Time Management Art on academic achievement among high school students in the Hashemite Kingdom of Jordan. The researcher employed the descriptive-analytic research to achieve the purpose of the study where he chose a sample of (2000) high school female and male students as respondents to the…

  12. Effects of a Collaborative Science Intervention on High Achieving Students' Learning Anxiety and Attitudes toward Science

    ERIC Educational Resources Information Center

    Hong, Zuway-R.

    2010-01-01

    This study investigated the effects of a collaborative science intervention on high achieving students' learning anxiety and attitudes toward science. Thirty-seven eighth-grade high achieving students (16 boys and 21 girls) were selected as an experimental group who joined a 20-week collaborative science intervention, which integrated and utilized…

  13. Individual and Longitudinal Differences among High and Low-Achieving, LD, and ADHD L2 Learners

    ERIC Educational Resources Information Center

    Sparks, Richard L.; Humbach, Nancy; Javorsky, James

    2008-01-01

    High-achieving (HA) and low-achieving (LA), learning disabled (LD), and attention deficit hyperactivity disorder (ADHD) high school students were followed over two years of L2 study and compared on measures of L1 literacy (reading and writing) in elementary school, L1 cognitive ability, L2 aptitude, oral and written L2 proficiency, and L2 word…

  14. International Note: Between-Domain Relations of Chinese High School Students' Academic Achievements

    ERIC Educational Resources Information Center

    Yangyang, Liu

    2012-01-01

    The present study examined the between-domain relations of Chinese high school students' academic achievements. In a sample of 1870 Chinese 10th grade students, the results indicated that Chinese high school students' academic achievements were correlated across nine subjects. In line with the previous Western findings, the findings suggested that…

  15. A Longitudinal Investigation of Project-Based Instruction and Student Achievement in High School Social Studies

    ERIC Educational Resources Information Center

    Summers, Emily J.; Dickinson, Gail

    2012-01-01

    This longitudinal study focused on how project-based instruction (PBI) influenced secondary social studies students' academic achievement and promoted College and Career Readiness (CCR). We explored and compared student achievement in a PBI high school versus a traditional instruction high school within the same rural school district. While…

  16. Parent-Child Relations and Psychological Adjustment among High-Achieving Chinese and European American Adolescents

    ERIC Educational Resources Information Center

    Qin, Desiree Baolian; Rak, Eniko; Rana, Meenal; Donnellan, M. Brent

    2012-01-01

    Chinese American students are often perceived as problem-free high achievers. Recent research, however, suggests that high-achieving Chinese American students can experience elevated levels of stress, especially comparing to their peers from other ethnic groups. In this paper, we examine how family dynamics may influence psychological adjustment…

  17. High-Achieving and Average Students' Reading Growth: Contrasting School and Summer Trajectories

    ERIC Educational Resources Information Center

    Rambo-Hernandez, Karen E.; McCoach, D. Betsy

    2015-01-01

    Much is unknown about how initially high-achieving students grow academically, especially given the measurement issues inherent in assessing growth for the highest performing students. This study compared initially high-achieving and average students' growth in reading (in a cohort of third-grade students from 2,000 schools) over 3 years.…

  18. Conformal Nets II: Conformal Blocks

    NASA Astrophysics Data System (ADS)

    Bartels, Arthur; Douglas, Christopher L.; Henriques, André

    2017-03-01

    Conformal nets provide a mathematical formalism for conformal field theory. Associated to a conformal net with finite index, we give a construction of the `bundle of conformal blocks', a representation of the mapping class groupoid of closed topological surfaces into the category of finite-dimensional projective Hilbert spaces. We also construct infinite-dimensional spaces of conformal blocks for topological surfaces with smooth boundary. We prove that the conformal blocks satisfy a factorization formula for gluing surfaces along circles, and an analogous formula for gluing surfaces along intervals. We use this interval factorization property to give a new proof of the modularity of the category of representations of a conformal net.

  19. The Meaning High-Achieving African-American Males in an Urban High School Ascribe to Mathematics

    ERIC Educational Resources Information Center

    Thompson, LaTasha; Davis, Julius

    2013-01-01

    Many researchers, educators, administrators, policymakers and members of the general public doubt the prevalence of high-achieving African-American males in urban high schools capable of excelling in mathematics. As part of a larger study, the current study explored the educational experiences of four high-achieving African-American males…

  20. Three-dimensional simple conformal symplectic particle-in-cell methods for simulations of high power microwave devices

    NASA Astrophysics Data System (ADS)

    Wang, Yue; Wang, Jianguo; Chen, Zaigao; Cheng, Guoxin; Wang, Pan

    2016-08-01

    To overcome the staircase error in the traditional particle-in-cell (PIC) method, a three dimensional (3D) simple conformal (SC) symplectic PIC method is presented in this paper. The SC symplectic finite integration technique (FIT) scheme is used to advance the electromagnetic fields without reduction of the time step. Particles are emitted from conformal boundaries with the charge conserving emission scheme and moved by using the relativistic Newton-Lorentz force equation. The symplectic formulas of auxiliary-differential equation, complex frequency shifted perfectly matched layer (ADE-CFS-PML) are given for truncating the open boundaries, numerical results show that the maximum relative error of truncation is less than 90 dB. Based on the surface equivalence theorem, the computing algorithms of conformal signals' injection are given, numerical results show that the algorithms can give the right mode patterns and the errors of cutoff frequencies could be as low as 0.1%. To verify the conformal algorithms, a magnetically insulated line oscillator is simulated, and the results are compared to those provided by using the 2.5D UNIPIC code, which show that they agree well. The results also show that the high order symplectic integration method can suppress the numerical Cherenkov radiation.

  1. Electrical control of protein conformation.

    PubMed

    Wan, Alwin M D; Schur, Rebecca M; Ober, Christopher K; Fischbach, Claudia; Gourdon, Delphine; Malliaras, George G

    2012-05-08

    Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as conformation gradients are achieved by applying an appropriate potential. These surfaces remain biologically relevant and support cell culture; hence, they may serve as a model to understand and control cell-surface interactions, with applications in basic research, medical diagnostics, and tissue engineering.

  2. Insights into the conformational equilibria of maltose-binding protein by analysis of high affinity mutants.

    PubMed

    Telmer, Patrick G; Shilton, Brian H

    2003-09-05

    The affinity of maltose-binding protein (MBP) for maltose and related carbohydrates was greatly increased by removal of groups in the interface opposite the ligand binding cleft. The wild-type protein has a KD of 1200 nM for maltose; mutation of residues Met-321 and Gln-325, both to alanine, resulted in a KD for maltose of 70 nM; deletion of 4 residues, Glu-172, Asn-173, Lys-175, and Tyr-176, which are part of a poorly ordered loop, results in a KD for maltose of 110 nM. Combining the mutations yields an increased affinity for maltodextrins and a KD of 6 nM for maltotriose. Comparison of ligand binding by the mutants, using surface plasmon resonance spectroscopy, indicates that decreases in the off-rate are responsible for the increased affinity. Small-angle x-ray scattering was used to demonstrate that the mutations do not significantly affect the solution conformation of MBP in either the presence or absence of maltose. The crystal structures of selected mutants showed that the mutations do not cause significant structural changes in either the closed or open conformation of MBP. These studies show that interactions in the interface opposite the ligand binding cleft, which we term the "balancing interface," are responsible for modulating the affinity of MBP for its ligand. Our results are consistent with a model in which the ligand-bound protein alternates between the closed and open conformations, and removal of interactions in the balancing interface decreases the stability of the open conformation, without affecting the closed conformation.

  3. Conformal Coating Strategy Comprising N-doped Carbon and Conventional Graphene for Achieving Ultrahigh Power and Cyclability of LiFePO4.

    PubMed

    Zhang, Kan; Lee, Jeong-Taik; Li, Ping; Kang, Byoungwoo; Kim, Jung Hyun; Yi, Gi-Ra; Park, Jong Hyeok

    2015-10-14

    Surface carbon coating to improve the inherent poor electrical conductivity of lithium iron phosphate (LiFePO4, LFP) has been considered as most efficient strategy. Here, we also report one of the conventional methods for LFP but exhibiting a specific capacity beyond the theoretical value, ultrahigh rate performance, and excellent long-term cyclability: the specific capacity is 171.9 mAh/g (70 μm-thick electrode with ∼10 mg/cm(2) loading mass) at 0.1 C (17 mA/g) and retains 143.7 mAh/g at 10 C (1.7 A/g) and 95.8% of initial capacity at 10 C after 1000 cycles. It was found that the interior conformal N-C coating enhances the intrinsic conductivity of LFP nanorods (LFP NR) and the exterior reduced graphene oxide coating acts as an electrically conducting secondary network to electrically connect the entire electrode. The great electron transport mutually promoted with shorten Li diffusion length on (010) facet exposed LFP NR represents the highest specific capacity value recorded to date at 10 C and ultralong-term cyclability. This conformal carbon coating approach can be a promising strategy for the commercialization of LFP cathode in lithium ion batteries.

  4. The impact of collective teacher efficacy on student achievement in high school science

    NASA Astrophysics Data System (ADS)

    Burcham, Mark W.

    This dissertation was designed to examine the impact of collective teacher efficacy on high school science achievement by looking at relationships among collective teacher efficacy, its two constructs, group competence and group task analysis, and high school science achievement scores at four rural high schools in Northwestern North Carolina. The researcher gathered historical test data from the testing coordinator from the school system and then administered the Collective Teacher Efficacy Instrument, developed by Goddard, Hoy, and Woolfolk Hoy (2000), to 24 science teachers from the four high schools. Using this information, the researcher conducted statistical analyses to determine the relationships among collective teacher efficacy, group competence, and group task analysis as compared with the tested science curriculum (physical science, biology, chemistry, and physics). The researcher also examined which construct was the most contributing factor and examined differences in efficacy levels and student achievement levels at each high school. Analysis of the data from this study indicated collective teacher efficacy, as well as its two constructs, group competence and group task analysis, does have a positive impact on student achievement in high school science. Analysis of the data revealed group competence is the major contributing factor for student achievement in biology and group task analysis is the major contributing factor for student achievement in physical science, chemistry, and physics. Further analysis of the data in this study, also revealed that the two high schools with the highest levels of collective teacher efficacy had the highest levels of student achievement.

  5. Achieving High Rates and High Uniformity in Copper Chemical Mechanical Polishing

    NASA Astrophysics Data System (ADS)

    Nolan, Lucy Marjorie

    The chemical mechanical polishing of Copper (Cu-CMP) is a complex and poorly understood process. Despite this, it is widely used throughout the semiconductor and microelectronics industries, and makes up a significant portion of wafer processing costs. In these contexts, desirable polishing outcomes such as a high rate of removal from the copper surface, and high removal rate uniformity, are achieved largely by trial-and-error. In this study, the same outcomes are pursued through a systematic investigation of polishing lubrication characteristics and abrasive and oxidiser concentrations in the polishing slurry. A strong link between lubrication characteristics, quantified by the dimensionless Sommerfield number, and the uniformity of polishing is demonstrated. A mechanism for the observed relationship is proposed, based on an adaptation of hydrodynamic lubrication theory. The overall rate of removal is maximized by polishing in a slurry containing oxidiser and abrasives in a synergistic ratio. Polishing away from this ratio has additional effects on the overall quality of the surface produced. Transport of slurry across the polishing pad is investigated by using tracers; the results demonstrate that slurry usage can be reduced in many circumstances with no impact on overall polishing outcomes, reducing overall processing costs. These findings are combined to design a polishing process, with good results.

  6. Achieving high strength and high ductility in magnesium alloy using hard-plate rolling (HPR) process

    PubMed Central

    Wang, Hui–Yuan; Yu, Zhao–Peng; Zhang, Lei; Liu, Chun–Guo; Zha, Min; Wang, Cheng; Jiang, Qi–Chuan

    2015-01-01

    Magnesium alloys are highly desirable for a wide range of lightweight structural components. However, rolling Mg alloys can be difficult due to their poor plasticity, and the strong texture yielded from rolling often results in poor plate forming ability, which limits their further engineering applications. Here we report a new hard-plate rolling (HPR) route which achieves a large reduction during a single rolling pass. The Mg-9Al-1Zn (AZ91) plates processed by HPR consist of coarse grains of 30–60 μm, exhibiting a typical basal texture, fine grains of 1–5 μm and ultrafine (sub) grains of 200–500 nm, both of the latter two having a weakened texture. More importantly, the HPR was efficient in gaining a simultaneous high strength and uniform ductility, i.e., ~371 MPa and ~23%, respectively. The superior properties should be mainly attributed to the cooperation effect of the multimodal grain structure and weakened texture, where the former facilitates a strong work hardening while the latter promotes the basal slip. The HPR methodology is facile and effective, and can avoid plate cracking that is prone to occur during conventional rolling processes. This strategy is applicable to hard-to-deform materials like Mg alloys, and thus has a promising prospect for industrial application. PMID:26603776

  7. Achieving high strength and high ductility in magnesium alloy using hard-plate rolling (HPR) process

    NASA Astrophysics Data System (ADS)

    Wang, Hui–Yuan; Yu, Zhao–Peng; Zhang, Lei; Liu, Chun–Guo; Zha, Min; Wang, Cheng; Jiang, Qi–Chuan

    2015-11-01

    Magnesium alloys are highly desirable for a wide range of lightweight structural components. However, rolling Mg alloys can be difficult due to their poor plasticity, and the strong texture yielded from rolling often results in poor plate forming ability, which limits their further engineering applications. Here we report a new hard-plate rolling (HPR) route which achieves a large reduction during a single rolling pass. The Mg-9Al-1Zn (AZ91) plates processed by HPR consist of coarse grains of 30-60 μm, exhibiting a typical basal texture, fine grains of 1-5 μm and ultrafine (sub) grains of 200-500 nm, both of the latter two having a weakened texture. More importantly, the HPR was efficient in gaining a simultaneous high strength and uniform ductility, i.e., ~371 MPa and ~23%, respectively. The superior properties should be mainly attributed to the cooperation effect of the multimodal grain structure and weakened texture, where the former facilitates a strong work hardening while the latter promotes the basal slip. The HPR methodology is facile and effective, and can avoid plate cracking that is prone to occur during conventional rolling processes. This strategy is applicable to hard-to-deform materials like Mg alloys, and thus has a promising prospect for industrial application.

  8. Achieving high strength and high ductility in magnesium alloy using hard-plate rolling (HPR) process.

    PubMed

    Wang, Hui-Yuan; Yu, Zhao-Peng; Zhang, Lei; Liu, Chun-Guo; Zha, Min; Wang, Cheng; Jiang, Qi-Chuan

    2015-11-25

    Magnesium alloys are highly desirable for a wide range of lightweight structural components. However, rolling Mg alloys can be difficult due to their poor plasticity, and the strong texture yielded from rolling often results in poor plate forming ability, which limits their further engineering applications. Here we report a new hard-plate rolling (HPR) route which achieves a large reduction during a single rolling pass. The Mg-9Al-1Zn (AZ91) plates processed by HPR consist of coarse grains of 30-60 μm, exhibiting a typical basal texture, fine grains of 1-5 μm and ultrafine (sub) grains of 200-500 nm, both of the latter two having a weakened texture. More importantly, the HPR was efficient in gaining a simultaneous high strength and uniform ductility, i.e., ~371 MPa and ~23%, respectively. The superior properties should be mainly attributed to the cooperation effect of the multimodal grain structure and weakened texture, where the former facilitates a strong work hardening while the latter promotes the basal slip. The HPR methodology is facile and effective, and can avoid plate cracking that is prone to occur during conventional rolling processes. This strategy is applicable to hard-to-deform materials like Mg alloys, and thus has a promising prospect for industrial application.

  9. New York State Superintendents and Board Presidents Attitudes on Superintendent Responsibilities in High-Achieving and Low-Achieving School Districts

    ERIC Educational Resources Information Center

    Murphy, Matthew J.

    2009-01-01

    The purpose of this study is to determine the perceptions of New York State superintendents and board presidents in high-achieving and low-achieving school districts on the six superintendent leadership responsibilities identified by Waters and Marzano (2006) and their relationship to improving student achievement: (1) creating research-relevant…

  10. Understanding and Reversing Underachievement, Low Achievement, and Achievement Gaps among High-Ability African American Males in Urban School Contexts

    ERIC Educational Resources Information Center

    Ford, Donna Y.; Moore, James L., III

    2013-01-01

    This article focuses on the achievement gap, with attention devoted to underachievement and low achievement among African American males in urban school contexts. More specifically, the article explains problems and issues facing or confronting these Black male students in urban education settings. A central part of this discussion is grounded in…

  11. Gender and High School Chemistry: Student Perceptions on Achievement in a Selective Setting

    ERIC Educational Resources Information Center

    Cousins, Andrew; Mills, Martin

    2015-01-01

    This paper reports on research undertaken in a middle-class Australian school. The focus of the research was on the relationship between gender and students' engagement with high school chemistry. Achievement data from many OECD [Organisation for Economic Co-operation and Development] countries suggest that middle-class girls are achieving equally…

  12. Achievement Motivation in High School: Contrasting Theoretical Models in the Classroom.

    ERIC Educational Resources Information Center

    Garcia-Celay, I. Montero; Tapia, J. Alonso

    1992-01-01

    Three models of achievement motivation in the classroom are contrasted. Results with 155 high school students suggest that the model of C. S. Dweck and E. S. Elliott offers a better explanation of the relationships among achievement motivation, attributions, emotional reactions, expectancies, and performance than do the other models. (SLD)

  13. Predicting Early Academic Failure in High School from Prior Academic Achievement, Psychosocial Characteristics, and Behavior

    ERIC Educational Resources Information Center

    Casillas, Alex; Robbins, Steve; Allen, Jeff; Kuo, Yi-Lung; Hanson, Mary Ann; Schmeiser, Cynthia

    2012-01-01

    The authors examined the differential effects of prior academic achievement, psychosocial, behavioral, demographic, and school context factors on early high school grade point average (GPA) using a prospective study of 4,660 middle-school students from 24 schools. The findings suggest that (a) prior grades and standardized achievement are the…

  14. Accelerated Mathematics and High-Ability Students' Math Achievement in Grades Three and Four

    ERIC Educational Resources Information Center

    Stanley, Ashley M.

    2011-01-01

    The purpose of this study was to explore the relationship between the use of a computer-managed integrated learning system entitled Accelerated Math (AM) as a supplement to traditional mathematics instruction on achievement as measured by TerraNova achievement tests of third and fourth grade high-ability students. Gender, socioeconomic status, and…

  15. An Analysis of Mathematics Course Sequences for Low Achieving Students at a Comprehensive Technical High School

    ERIC Educational Resources Information Center

    Edge, D. Michael

    2011-01-01

    This non-experimental study attempted to determine how the different prescribed mathematic tracks offered at a comprehensive technical high school influenced the mathematics performance of low-achieving students on standardized assessments of mathematics achievement. The goal was to provide an analysis of any statistically significant differences…

  16. The Impact of Charter Schools on Promoting High Levels of Mathematics Achievement

    ERIC Educational Resources Information Center

    Plucker, Jonathan A.; Makel, Matthew C.; Rapp, Kelly E.

    2007-01-01

    This study compares achievement levels for high ability students attending charter schools and students in traditional public schools in Georgia. Researchers examined student achievement (as assessed by the state's Criterion-Referenced Competency Tests) using three comparison groups: students in the closest traditional schools with similar grade…

  17. A Quantitative Comparison of Pennsylvania High School Student Achievement by Middle States Association's Accreditation Status

    ERIC Educational Resources Information Center

    Johnson, Christopher A.

    2012-01-01

    As public school accountability for student achievement has continued to increase, prior to and as a result of the No Child Left Behind Act of 2001, schools have sought ways of bringing new instructional services to their students to raise their levels of achievement. Some Pennsylvania public high schools have attempted to improve student…

  18. Unforgiving Confucian Culture: A Breeding Ground for High Academic Achievement, Test Anxiety and Self-Doubt?

    ERIC Educational Resources Information Center

    Stankov, Lazar

    2010-01-01

    This paper reviews findings from several studies that contribute to our understanding of cross-cultural differences in academic achievement, anxiety and self-doubt. The focus is on comparisons between Confucian Asian and European regions. Recent studies indicate that high academic achievement of students from Confucian Asian countries is…

  19. Instructional, Transformational, and Managerial Leadership and Student Achievement: High School Principals Make a Difference

    ERIC Educational Resources Information Center

    Valentine, Jerry W.; Prater, Mike

    2011-01-01

    This statewide study examined the relationships between principal managerial, instructional, and transformational leadership and student achievement in public high schools. Differences in student achievement were found when schools were grouped according to principal leadership factors. Principal leadership behaviors promoting instructional and…

  20. Cohort versus Non-Cohort High School Students' Math Performance: Achievement Test Scores and Coursework

    ERIC Educational Resources Information Center

    Parke, Carol S.; Keener, Dana

    2011-01-01

    The purpose of this study is to compare multiple measures of mathematics achievement for 1,378 cohort students who attended the same high school in a district from 9th to 12th grade with non-cohort students in each grade level. Results show that mobility had an impact on math achievement. After accounting for gender, ethnicity, and SES, adjusted…

  1. A modified infrared spectrometer with high time resolution and its application for investigating fast conformational changes of the GTPase Ras.

    PubMed

    Lin, Jie; Gerwert, Klaus; Kötting, Carsten

    2014-01-01

    Time-resolved infrared spectroscopy is a valuable tool for the investigation of proteins and protein interactions. The investigation of many biological processes is possible by means of caged compounds, which set free biologically active substances upon light activation. Some caged compounds could provide sub-nanosecond time resolution, e.g., para-hydroxyphenacyl-guanosine 5'-triphosphate (GTP) forms GTP in picoseconds. However, the time resolution in single shot experiments with rapid-scan Fourier transform infrared (FT-IR) spectrometers is limited to about 10 ms. Here we use an infrared diode laser instead of the conventional globar and achieve a time resolution of 100 ns. This allows for the time-resolved measurement of the fast Ras(off) to Ras(on) conformational change at room temperature. We quantified the activation parameters for this reaction and found that the free energy of activation for this reaction is mainly enthalpic. Investigation of the same reaction in the presence of the Ras binding domain of the effector Raf (RafRBD) reveals a four orders of magnitude faster reaction, indicating that Ras·RafRBD complex formation directly induces the conformational change. Recent developments of broadly tunable quantum cascade lasers will further improve time resolution and usability of the setup. The reported 100 ns time resolution is the best achieved for a non-repetitive experiment so far.

  2. Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.

    PubMed

    Luo, Bing-Hao; Takagi, Junichi; Springer, Timothy A

    2004-03-12

    Although integrin alpha subunit I domains exist in multiple conformations, it is controversial whether integrin beta subunit I-like domains undergo structurally analogous movements of the alpha7-helix that are linked to affinity for ligand. Disulfide bonds were introduced into the beta(3) integrin I-like domain to lock its beta6-alpha7 loop and alpha7-helix in two distinct conformations. Soluble ligand binding, ligand mimetic mAb binding and cell adhesion studies showed that disulfide-bonded receptor alpha(IIb)beta(3)(T329C/A347C) was locked in a low affinity state, and dithiothreitol treatment restored the capability of being activated to high affinity binding; by contrast, disulfide-bonded alpha(IIb)beta(3)(V332C/M335C) was locked in a high affinity state. The results suggest that activation of the beta subunit I-like domain is analogous to that of the alpha subunit I domain, i.e. that axial movement in the C-terminal direction of the alpha7-helix is linked to rearrangement of the I-like domain metal ion-dependent adhesion site into a high affinity conformation.

  3. Impacts of comprehensive reading instruction on diverse outcomes of low- and high-achieving readers.

    PubMed

    Guthrie, John T; McRae, Angela; Coddington, Cassandra S; Lutz Klauda, Susan; Wigfield, Allan; Barbosa, Pedro

    2009-01-01

    Low-achieving readers in Grade 5 often lack comprehension strategies, domain knowledge, word recognition skills, fluency, and motivation to read. Students with such multiple reading needs seem likely to benefit from instruction that supports each of these reading processes. The authors tested this expectation experimentally by comparing the effects of Concept-Oriented Reading Instruction (CORI) with traditional instruction (TI) on several outcomes in a 12-week intervention for low achievers and high achievers. Low achievers in the CORI group were afforded explicit instruction, leveled texts, and motivation support. Compared with TI students, CORI students scored higher on posttest measures of word recognition speed, reading comprehension on the Gates-MacGinitie Reading Test, and ecological knowledge. CORI was equally effective for lower achievers and higher achievers. Explicitly supporting multiple aspects of reading simultaneously appeared to benefit diverse learners on a range of reading outcomes.

  4. Understanding the Elements of Operational Reliability: A Key for Achieving High Reliability

    NASA Technical Reports Server (NTRS)

    Safie, Fayssal M.

    2010-01-01

    This viewgraph presentation reviews operational reliability and its role in achieving high reliability through design and process reliability. The topics include: 1) Reliability Engineering Major Areas and interfaces; 2) Design Reliability; 3) Process Reliability; and 4) Reliability Applications.

  5. A Quantitative Literature Review of Cooperative Learning Effects on High School and College Chemistry Achievement.

    ERIC Educational Resources Information Center

    Bowen, Craig W.

    2000-01-01

    Describes meta-analysis, a quantitative approach to conducting literature reviews. Illustrates the power of this technique by reporting the quantitative effects of cooperative learning on chemistry achievement in high school and college classes. (Contains 32 references.) (WRM)

  6. Efficient sampling of protein conformational space using fast loop building and batch minimization on highly parallel computers.

    PubMed

    Tyka, Michael D; Jung, Kenneth; Baker, David

    2012-12-05

    All-atom sampling is a critical and compute-intensive end stage to protein structural modeling. Because of the vast size and extreme ruggedness of conformational space, even close to the native structure, the high-resolution sampling problem is almost as difficult as predicting the rough fold of a protein. Here, we present a combination of new algorithms that considerably speed up the exploration of very rugged conformational landscapes and are capable of finding heretofore hidden low-energy states. The algorithm is based on a hierarchical workflow and can be parallelized on supercomputers with up to 128,000 compute cores with near perfect efficiency. Such scaling behavior is notable, as with Moore's law continuing only in the number of cores per chip, parallelizability is a critical property of new algorithms. Using the enhanced sampling power, we have uncovered previously invisible deficiencies in the Rosetta force field and created an extensive decoy training set for optimizing and testing force fields.

  7. A Comparison of Emotional-Motivational (A-R-D Theory) Personality Characteristics in Learning Disabled, Normal Achieving, and High Achieving Children.

    ERIC Educational Resources Information Center

    Hufano, Linda D.

    The study examined emotional-motivational personality characteristics of 15 learning disabled, 15 normal achieving, and 15 high achieving students (grades 3-5). The study tested the hypothesis derived from the A-R-D (attitude-reinforcer-discriminative) theory of motivation that learning disabled (LD) children differ from normal and high achieving…

  8. The Outward Bound Bridging Course for Low-Achieving High School Males: Effect on Academic Achievement and Multidimensional Self-Concepts.

    ERIC Educational Resources Information Center

    Marsh, Herbert W.; Richards, Garry

    The Outward Bound Bridging Course is a 6-week residential program designed to improve academic achievement and self-concepts in low-achieving high school males. During 1980-1984, five courses were conducted for 66 Australian high school males. Most of them were ninth grade students, chosen on the basis of poor academic performance, an apparent…

  9. Probing the binding behavior and conformational states of globular proteins in reversed-phase high-performance liquid chromatography.

    PubMed

    Purcell, A W; Aguilar, M I; Hearn, M T

    1999-07-01

    Reversed-phase high-performance liquid chromatography (RP-HPLC) is a widely used technique for the separation of proteins under low pH aquo-organic solvent gradient elution conditions, typically carried out at ambient temperatures. These conditions can however induce conformational effects with proteins as evident from changes in their biological or immunological activities. By monitoring the influence of temperature on the retention and band-broadening characteristics of proteins, the role of conformational processes in these lipophilic environments can be examined. These processes can then be interpreted in terms of a two-state model involving a native (N) and a fully unfolded species (U) or more complex folding/unfolding models. In the present study, the gradient elution RP-HPLC behavior of sperm whale myoglobin (SWMYO) and hen egg white lysozyme (HEWL) has been investigated at temperatures between 5 and 85 degrees C with n-octadecyl (C18)- and n-butyl (C4)-silica reversed-phase sorbents. The interaction of these proteins with these reversed-phase sorbents has also been examined in terms of the contributions that the heme prosthetic group of SWMYO and the disulfide bonds in HEWL make to the stabilization of the native conformation of these proteins in these hydrophobic environments. The observed interconversions of multiple peak zones of SWMYO and HEWL in the presence of C18 and C4 ligands have been subsequently analyzed in terms of the unfolding processes that these proteins can undergo at low pH and at elevated temperatures. The ability of hydrocarbonaceous ligands to trap ensemblies of partially unfolded conformational intermediates of proteins in these perturbing environments has been examined. Pseudo-first-order rate constants have been derived for these processes from analysis of the dependencies on time of the concentration of the different protein species at specified temperatures. The relationship of these processes to the conformational transitions

  10. Race and Ethnic Differences in College Achievement: Does High School Attended Matter?

    PubMed Central

    Fletcher, Jason M.; Tienda, Marta

    2012-01-01

    This paper uses 10 years of enrollment data at four Texas public universities to examine whether, to what extent, and in what ways high school attended contributes to racial and ethnic differences in college achievement. Like previous studies, we show that controlling for observable pre-college achievement variables (e.g. test scores, class rank) shrinks, but does not eliminate, sizable racial differences in college achievement. Fixed-effects models that take into account differences across high schools that minority and nonminority youth attend largely eliminate, and often reverse, black-white and Hispanic-white gaps in several measures of college achievement. Our results, which are quite robust across universities of varying selectivity, illustrate how high school quality foments race and ethnic inequality in postsecondary achievement. Leveling inequities in the quality of high schools that minority students attend is a long-run agenda, but remediation programs that compensate for instructional shortfalls at low performing high schools may help close achievement gaps in the interim. PMID:23136447

  11. Race and Ethnic Differences in College Achievement: Does High School Attended Matter?

    PubMed

    Fletcher, Jason M; Tienda, Marta

    2010-01-01

    This paper uses 10 years of enrollment data at four Texas public universities to examine whether, to what extent, and in what ways high school attended contributes to racial and ethnic differences in college achievement. Like previous studies, we show that controlling for observable pre-college achievement variables (e.g. test scores, class rank) shrinks, but does not eliminate, sizable racial differences in college achievement. Fixed-effects models that take into account differences across high schools that minority and nonminority youth attend largely eliminate, and often reverse, black-white and Hispanic-white gaps in several measures of college achievement. Our results, which are quite robust across universities of varying selectivity, illustrate how high school quality foments race and ethnic inequality in postsecondary achievement. Leveling inequities in the quality of high schools that minority students attend is a long-run agenda, but remediation programs that compensate for instructional shortfalls at low performing high schools may help close achievement gaps in the interim.

  12. Application of Metabolic 13C Labeling in Conjunction with High-Field Nuclear Magnetic Resonance Spectroscopy for Comparative Conformational Analysis of High Mannose-Type Oligosaccharides

    PubMed Central

    Kamiya, Yukiko; Yanagi, Kotaro; Kitajima, Toshihiko; Yamaguchi, Takumi; Chiba, Yasunori; Kato, Koichi

    2013-01-01

    High mannose-type oligosaccharides are enzymatically trimmed in the endoplasmic reticulum, resulting in various processing intermediates with exposed glycotopes that are recognized by a series of lectins involved in glycoprotein fate determination in cells. Although recent crystallographic data have provided the structural basis for the carbohydrate recognition of intracellular lectins, atomic information of dynamic oligosaccharide conformations is essential for a quantitative understanding of the energetics of carbohydrate–lectin interactions. Carbohydrate NMR spectroscopy is useful for characterizing such conformational dynamics, but often hampered by poor spectral resolution and lack of recombinant techniques required to produce homogeneous glycoforms. To overcome these difficulties, we have recently developed a methodology for the preparation of a homogeneous high mannose-type oligosaccharide with 13C labeling using a genetically engineered yeast strain. We herein successfully extended this method to result in the overexpression of 13C-labeled Man9GlcNAc2 (M9) with a newly engineered yeast strain with the deletion of four genes involved in N-glycan processing. This enabled high-field NMR analyses of 13C-labeled M9 in comparison with its processing product lacking the terminal mannose residue ManD2. Long-range NOE data indicated that the outer branches interact with the core in both glycoforms, and such foldback conformations are enhanced upon the removal of ManD2. The observed conformational variabilities might be significantly associated with lectins and glycan-trimming enzymes. PMID:24970159

  13. Highly conformal CT based surface mould brachytherapy for non-melanoma skin cancers of earlobe and nose

    PubMed Central

    Kozłowski, Sławomir; Pietraszek, Andrzej; Pietrzykowska-Kuncman, Malwina; Danielska, Justyna; Sobotkowski, Janusz; Łuniewska-Bury, Jolanta; Fijuth, Jacek

    2016-01-01

    Purpose Brachytherapy (BT), due to rapid dose fall off and minor set-up errors, should be superior to external beam radiotherapy (EBRT) for treatment of lesions in difficult locations like nose and earlobe. Evidences in this field are scarce. We describe computed tomography (CT) based surface mould BT for non-melanoma skin cancers (NMSC), and compare its conformity, dose coverage, and tissue sparing ability to EBRT. Material and methods We describe procedure of preparation of surface mould applicator and dosimetry parameters of BT plans, which were implemented in 10 individuals with NMSC of nose and earlobe. We evaluated dose coverage by minimal dose to 90% of planning target volume (PTV) (D90), volumes of PTV receiving 90-150% of prescribed dose (PD) (VPTV90-150), conformal index for 90 and 100% of PD (COIN90, COIN100), dose homogeneity index (DHI), dose nonuniformity ratio (DNR), exposure of organs. Prospectively, we created CT-based photons and electrons plans. We compared conformity (COIN90, COIN100), dose coverage of PTV (D90, VPTV90, VPTV100), volumes of body receiving 10-90% of PD (V10-V90) of EBRT and BT plans. Results We obtained mean BT-DHI = 0.76, BT-DNR = 0.23, EBRT-DHI = 1.26. We observed no significant differences in VPTV90 and D90 between BT and EBRT. Mean BT-VPTV100 (89.4%) was higher than EBRT-VPTV100 (71.2%). Both COIN90 (BT-COIN90 = 0.46 vs. EBRT-COIN90 = 0.21) and COIN100 (BT-COIN100 = 0.52 vs. EBRT-COIN100 = 0.26) were superior for BT plans. We observed more exposure of normal tissues for small doses in BT plans (V10, V20), for high doses in EBRT plans (V70, V90). Conclusions Computed tmography-based surface mould brachytherapy for superficial lesions on irregular surfaces is a highly conformal method with good homogeneity. Brachytherapy is superior to EBRT in those locations in terms of conformity and normal tissue sparing ability in high doses. PMID:27504128

  14. Evaluation of High Density Air Traffic Operations with Automation for Separation Assurance, Weather Avoidance and Schedule Conformance

    NASA Technical Reports Server (NTRS)

    Prevot, Thomas; Mercer, Joey S.; Martin, Lynne Hazel; Homola, Jeffrey R.; Cabrall, Christopher D.; Brasil, Connie L.

    2011-01-01

    In this paper we discuss the development and evaluation of our prototype technologies and procedures for far-term air traffic control operations with automation for separation assurance, weather avoidance and schedule conformance. Controller-in-the-loop simulations in the Airspace Operations Laboratory at the NASA Ames Research Center in 2010 have shown very promising results. We found the operations to provide high airspace throughput, excellent efficiency and schedule conformance. The simulation also highlighted areas for improvements: Short-term conflict situations sometimes resulted in separation violations, particularly for transitioning aircraft in complex traffic flows. The combination of heavy metering and growing weather resulted in an increased number of aircraft penetrating convective weather cells. To address these shortcomings technologies and procedures have been improved and the operations are being re-evaluated with the same scenarios. In this paper we will first describe the concept and technologies for automating separation assurance, weather avoidance, and schedule conformance. Second, the results from the 2010 simulation will be reviewed. We report human-systems integration aspects, safety and efficiency results as well as airspace throughput, workload, and operational acceptability. Next, improvements will be discussed that were made to address identified shortcomings. We conclude that, with further refinements, air traffic control operations with ground-based automated separation assurance can routinely provide currently unachievable levels of traffic throughput in the en route airspace.

  15. Social Goals, Social Status, and Problem Behavior among Low-Achieving and High-Achieving Adolescents from Rural Schools

    ERIC Educational Resources Information Center

    Ludden, Alison Bryant

    2012-01-01

    The current research examines how social goals and perceptions of what is needed for social status at school relate to school misbehavior and substance use among rural adolescents (N = 683). Results indicate that social goals and perceptions of social status have differential links to problem behaviors depending upon adolescents' achievement.…

  16. Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy.

    PubMed

    Baldwin, Andrew J; Walsh, Patrick; Hansen, D Flemming; Hilton, Gillian R; Benesch, Justin L P; Sharpe, Simon; Kay, Lewis E

    2012-09-19

    Solution- and solid-state nuclear magnetic resonance (NMR) spectroscopy are highly complementary techniques for studying supra-molecular structure. Here they are employed for investigating the molecular chaperone αB-crystallin, a polydisperse ensemble of between 10 and 40 identical subunits with an average molecular mass of approximately 600 kDa. An IxI motif in the C-terminal region of each of the subunits is thought to play a critical role in regulating the size distribution of oligomers and in controlling the kinetics of subunit exchange between them. Previously published solid-state NMR and X-ray results are consistent with a bound IxI conformation, while solution NMR studies provide strong support for a highly dynamic state. Here we demonstrate through FROSTY (freezing rotational diffusion of protein solutions at low temperature and high viscosity) MAS (magic angle spinning) NMR that both populations are present at low temperatures (<0 °C), while at higher temperatures only the mobile state is observed. Solution NMR relaxation dispersion experiments performed under physiologically relevant conditions establish that the motif interchanges between flexible (highly populated) and bound (sparsely populated) states. This work emphasizes the importance of using multiple methods in studies of supra-molecules, especially for highly dynamic ensembles where sample conditions can potentially affect the conformational properties observed.

  17. The Impact of Block Scheduling on Student Achievement, Attendance, and Discipline at the High School Level

    ERIC Educational Resources Information Center

    Williams, Charles, Jr.

    2011-01-01

    The purpose of this study was to determine the impact block scheduling has on (a) student academic achievement, discipline, and attendance, and (b) administrator, teacher, and student perceptions. The study compared 2005-2010 data from a high school utilizing the A/B block schedule and a high school under a traditional schedule, in one suburban…

  18. The Role of Teachers at University: What Do High Achiever Students Look for?

    ERIC Educational Resources Information Center

    Monteiro, Silvia; Almeida, Leandro S.; Vasconcelos, Rosa M.

    2012-01-01

    The perceptions of students about their teachers have interested the academic and scientific community, regarding the improvement of the quality of higher education. This paper presents data obtained from interviews conducted with ten high achiever engineering students and focuses on the characteristics of teachers that are highly valued by the…

  19. Study-Orientation of High and Low Academic Achievers at Secondary Level in Pakistan

    ERIC Educational Resources Information Center

    Sarwar, Muhammad; Bashir, Muhammad; Khan, Muhammad Naemullah; Khan, Muhammad Saeed

    2009-01-01

    The study orientation of low and high academic achievers was compared, measured through a self-developed study orientation scale (SOS) primarily based on 47 items comparing study habits and attitude. Students' marks obtained in the 10th grade Examination determined the measure of academic performance. The analysis revealed that the high achievers…

  20. What Works Clearinghouse Quick Review: "Expanding College Opportunities for High-Achieving, Low Income Students"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2013

    2013-01-01

    This study examined the effects of providing low-income, high-achieving high school seniors with college application guidance and information about the costs of college. The "application guidance" included information about deadlines and requirements for college applications at nearby institutions, at the state's flagship institution, and at in-…

  1. The Relationship between Self-Efficacy and Achievement in At-Risk High School Students

    ERIC Educational Resources Information Center

    Gold, Jarrett Graham

    2010-01-01

    The focus of this quantitative survey study was the examination of the relationship between self-efficacy and academic achievement in 164 at-risk high school students. The study used Bandura's self-efficacy as the theoretical framework. The research questions involved understanding the levels of self-efficacy in at-risk high school students and…

  2. The Contribution of Limbic Learning Aptitude to Achievement in High School. Final Report.

    ERIC Educational Resources Information Center

    Ax, Albert F.; And Others

    Achievement in earning grades in high school was resolved into its intellectual and motivational components. This study employed tests of I.Q., personality inventories and classical and operant conditioning of autonomic nervous system controlled variables. Eleven procedures were given to 99 Black inner city high school seniors. Six physiological…

  3. The Effects of Modeling Instruction on High School Physics Academic Achievement

    ERIC Educational Resources Information Center

    Wright, Tiffanie L.

    2012-01-01

    The purpose of this study was to explore whether Modeling Instruction, compared to traditional lecturing, is an effective instructional method to promote academic achievement in selected high school physics classes at a rural middle Tennessee high school. This study used an "ex post facto," quasi-experimental research methodology. The…

  4. Improving High School Students' Mathematics Achievement through the Use of Motivational Strategies.

    ERIC Educational Resources Information Center

    Portal, Jamie; Sampson, Lisa

    This report describes a program for motivating students in mathematics in order to improve achievement at the high school level. The targeted population consisted of high school students in a middle class community located in a suburb of a large metropolitan area. The problems of underachievement were documented through data collected from surveys…

  5. Coping with High-Achieving Transnationalist Immigrant Students: The Experience of Israeli Teachers

    ERIC Educational Resources Information Center

    Eisikovits, Rivka A.

    2008-01-01

    Little attention has been paid to teacher attitudes toward high-achieving culturally diverse student groups. This in-depth study focuses on the experience of Israeli teachers who tell the story of a decade and a half of educational work with their highly motivated, academically successful immigrant students from the Former Soviet Union. The paper…

  6. 10 Strategies for Raising Achievement and Improving High School Completion Rates

    ERIC Educational Resources Information Center

    Bottoms, Gene

    2004-01-01

    No state can afford to have the percentage of young people who are failing to finish high school remain at the present levels nor can they afford to ease the standards. This document discusses the following 10 strategies that states can implement to raise achievement and increase high school completion rates: (1) Initiate a transition program for…

  7. Emotional Intelligence as a Predictor of Leadership of Kuwaiti High and Low Achieving 11th Graders

    ERIC Educational Resources Information Center

    Alnabhan, Mousa

    2010-01-01

    The current study examined the association between emotional intelligence (EI) and the Leadership components (L) of high school students in the state of Kuwait. The possibility of predicting each leadership component via emotional intelligence components was investigated for high and low achievers. A sample of 11th grade students from Kuwaiti…

  8. Dual Enrollment Programs: A Comparative Study of High School Students' College Academic Achievement at Different Settings

    ERIC Educational Resources Information Center

    Flores, Agnes L. Acker

    2012-01-01

    The "ex post facto" causal-comparative study examined the academic achievement of high school students who took their dual credit English or mathematics college credit-bearing course in two different environments, namely, the college setting and the high school setting. Due to non-experimental nature of the study, no causal inferences…

  9. Classroom Environment, Instructional Resources, and Teaching Differences in High-Performing Kentucky Schools with Achievement Gaps.

    ERIC Educational Resources Information Center

    Meehan, Merrill L.; Cowley, Kimberly S.; Schumacher, Debbie; Hauser, Brenda; Croom, Nona D. M.

    This study examined differences at the classroom level between Kentucky schools with minimum versus large gaps in academic achievement between particular groups of students. Data were gathered via observations of 213 classrooms at 18 elementary, middle, and high schools. Although all the schools were identified as high-performing in terms of…

  10. A Case Study of 21st Century Skills in High Achieving Elementary Schools in Pennsylvania

    ERIC Educational Resources Information Center

    Egnor, Gregory P.

    2013-01-01

    This study examines if practices that advocate for 21st century skills are in conflict with the mandates of NCLB. Interviews with influential school leaders of high achieving elementary schools focused on collecting data about 21st century skills. This study was designed to (a) Determine if 21st century skills are addressed in high achieving…

  11. Small Classes in the Early Grades, Academic Achievement, and Graduating From High School

    ERIC Educational Resources Information Center

    Finn, Jeremy D.; Gerber, Susan B.; Boyd-Zaharias, Jayne

    2005-01-01

    This investigation addressed 3 questions about the long-term effects of early school experiences: (a) Is participation in small classes in the early grades (K-3) related to high school graduation? (b) Is academic achievement in K-3 related to high school graduation? (c) If class size is related to graduation, is the relationship explained by the…

  12. The Relationship between Thinking Style Differences and Career Choices for High-Achieving Students

    ERIC Educational Resources Information Center

    Kim, Mihyeon

    2011-01-01

    The intent of this study was to present information about high-achieving students' career decision making associated with thinking styles. We gathered data from two International Baccalaureate (IB) programs and a Governor's School Program with a sample of 209 high-school students. The findings of this study demonstrated that the effect of program…

  13. Transportation Conformity

    EPA Pesticide Factsheets

    This section provides information on: current laws, regulations and guidance, policy and technical guidance, project-level conformity, general information, contacts and training, adequacy review of SIP submissions

  14. Does Homogeneous Ability Grouping for High School Honors English Instruction Benefit the High Achiever?

    ERIC Educational Resources Information Center

    Hostetter, Douglas Paul

    2013-01-01

    Public schools are examining their policies and instructional practices to address the achievement gap exposed by the reporting requirements of NCLB (Wenglinski, 2004). As accountability measures and stakes rise, there is a call for an improved use of scientific evidence to inform educational policymaking (Wiseman, 2010). In terms of the…

  15. Academic achievement and career choice in science: Perceptions of African American urban high school students

    NASA Astrophysics Data System (ADS)

    Jones, Sheila Kay

    2007-12-01

    Low test scores in science and fewer career choices in science among African American high school students than their White counterparts has resulted in lower interest during high school and an underrepresentation of African Americans in science and engineering fields. Reasons for this underachievement are not known. This qualitative study used a grounded theory methodology to examine what influence parental involvement, ethnic identity, and early mentoring had on the academic achievement in science and career choice in science of African American urban high school 10th grade students. Using semi-structured open-ended questions in individual interviews and focus groups, twenty participants responded to questions about African American urban high school student achievement in science and their career choice in science. The median age of participants was 15 years; 85% had passed either high school biology or physical science. The findings of the study revealed influences and interactions of selected factors on African American urban high school achievement in science. Sensing potential emerged as the overarching theme with six subthemes; A Taste of Knowledge, Sounds I Hear, Aromatic Barriers, What Others See, The Touch of Others, and The Sixth Sense. These themes correlate to the natural senses of the human body. A disconnect between what science is, their own individual learning and success, and what their participation in science could mean for them and the future of the larger society. Insight into appropriate intervention strategies to improve African American urban high school achievement in science was gained.

  16. Patterns of Self-Regulation: Patterns of Self-Regulatory Strategy Use among Low-Achieving and High-Achieving University Students

    ERIC Educational Resources Information Center

    Ruban, Lilia; Reis, Sally M.

    2006-01-01

    The present mixed-methods study attempts to provide insights into the nature, idiosyncrasies, and inter- and intra-individual patterns of academic self-regulatory strategy use among two different populations of university students. Low-achieving (n = 49) and high-achieving students (n = 131) described their self-regulatory strategy use in their…

  17. Predicting bioactive conformations and binding modes of macrocycles

    NASA Astrophysics Data System (ADS)

    Anighoro, Andrew; de la Vega de León, Antonio; Bajorath, Jürgen

    2016-10-01

    Macrocyclic compounds experience increasing interest in drug discovery. It is often thought that these large and chemically complex molecules provide promising candidates to address difficult targets and interfere with protein-protein interactions. From a computational viewpoint, these molecules are difficult to treat. For example, flexible docking of macrocyclic compounds is hindered by the limited ability of current docking approaches to optimize conformations of extended ring systems for pose prediction. Herein, we report predictions of bioactive conformations of macrocycles using conformational search and binding modes using docking. Conformational ensembles generated using specialized search technique of about 70 % of the tested macrocycles contained accurate bioactive conformations. However, these conformations were difficult to identify on the basis of conformational energies. Moreover, docking calculations with limited ligand flexibility starting from individual low energy conformations rarely yielded highly accurate binding modes. In about 40 % of the test cases, binding modes were approximated with reasonable accuracy. However, when conformational ensembles were subjected to rigid body docking, an increase in meaningful binding mode predictions to more than 50 % of the test cases was observed. Electrostatic effects did not contribute to these predictions in a positive or negative manner. Rather, achieving shape complementarity at macrocycle-target interfaces was a decisive factor. In summary, a combined computational protocol using pre-computed conformational ensembles of macrocycles as a starting point for docking shows promise in modeling binding modes of macrocyclic compounds.

  18. 2×2 dominant achievement goal profiles in high-level swimmers.

    PubMed

    Fernandez-Rio, Javier; Cecchini Estrada, Jose A; Mendez-Giménez, Antonio; Fernández-Garcia, Benjamín; Saavedra, Pablo

    2014-01-01

    The goal of this study was to assess achievement goal dominance, self-determined situational motivation and competence in high-level swimmers before and after three training sessions set at different working intensities (medium, sub-maximal and maximal). Nineteen athletes (males, n=9, 18.00±2.32 years; females, n=10, 16.30±2.01 years, range = 14-18) agreed to participate. They completed a questionnaire that included the Dominant Achievement Goal assessment instrument, the 2×2 Achievement Goals Questionnaire for Sport (AGQ-S), The Situational Motivation Scale (SIMS) and the Competence subscale of the Basic Psychological Needs in Exercise questionnaire (BPNES). Results indicated that participants overwhelmingly showed mastery-approach achievement goal dominance, and it remained stable at the conclusion of the different training sessions under all intensity levels. This profile was positively correlated to self-determined situational motivation and competence. However, swimmers' feelings of competence increased only after the medium intensity level training session. After the completion of the maximal intensity training session, swimmers' self-determined motivation was significantly lower compared to the other two training sessions, which could be caused by a temporary period of burnout. Results indicated that high-level swimmers had a distinct mastery-approach dominant achievement goal profile that was not affected by the workload of the different training sessions. They also showed high levels of self-determined situational motivation and competence. However, heavy workloads should be controlled because they can cause transitory burnout.

  19. High IQ Is Sufficient to Explain the High Achievements in Math and Science of the East Asian Peoples

    ERIC Educational Resources Information Center

    Lynn, Richard

    2010-01-01

    It is argued that it is unnecessary to propose that Confucian values explain the high achievements in math and science of the North East Asian peoples, and that these can be satisfactorily and more parsimoniously be explained by their high IQs.

  20. "It's a Way of Life for Us": High Mobility and High Achievement in Department of Defense Schools.

    ERIC Educational Resources Information Center

    Smrekar, Claire E.; Owens, Debra E.

    2003-01-01

    Examines the academic performance of students in U.S. Department of Defense Education Activity (DoDEA) schools, which have high student mobility. Some observers contend that these students' high achievement is a function of their middle class family and community characteristics. Asserts that DoDEA schools simultaneously "do the right…

  1. Highly conforming polyethylene inlays reduce the in vivo variability of knee joint kinematics after total knee arthroplasty.

    PubMed

    Daniilidis, Kiriakos; Skwara, Adrian; Vieth, Volker; Fuchs-Winkelmann, Susanne; Heindel, Walter; Stückmann, Volker; Tibesku, Carsten O

    2012-08-01

    The use of highly conforming polyethylene inlays in total knee arthroplasty (TKA) provides improved anteroposterior stability. The aim of this fluoroscopic study was to investigate the in vivo kinematics during unloaded and loaded active extension with a highly conforming inlay and a flat inlay after cruciate retaining (CR) total knee arthroplasty (TKA). Thirty one patients (50 knees) received a fixed-bearing cruciate retaining total knee arthroplasty (Genesis II, Smith & Nephew, Schenefeld, Germany) for primary knee osteoarthritis. Twenty two of them received a flat polyethylene inlay (PE), nine a deep dished PE and 19 were in the control group (physiological knees). The mean age at the time of surgery was 62 years. Dynamic examination with fluoroscopy was performed to assess the "patella tendon angle" in relation to the knee flexion angle (measure of anteroposterior translation) and the "kinematic index" (measure of reproducibility). Fluoroscopy was performed under active extension and flexion, during unloaded movement, and under full weight bearing, simulated by step climbing. No significant difference was observed between both types of polyethylene inlay designs and the physiological knee during unloaded movement. Anteroposterior (AP) instability was found during weight-bearing movement. The deep-dish inlay resulted in lower AP translation and a non-physiological rollback. Neither inlay types could restore physiological kinematics of the knee. Despite the fact that deep dished inlays reduce the AP translation, centralisation of contact pressure results in non-physiological rollback. The influence of kinematic pattern variability on clinical results warrants further investigation.

  2. Effects of Part-Time Work on School Achievement During High School

    ERIC Educational Resources Information Center

    Singh, Kusum; Chang, Mido; Dika, Sandra

    2007-01-01

    The authors explored the effects of part-time work on school achievement during high school. To estimate the true effects of part-time work on school grades, the authors included family background, students' educational aspirations, and school engagement as controls. Although a substantial literature exists on the relationship of part-time work…

  3. The Federal Transformation Intervention Model in Persistently Lowest Achieving High Schools: A Mixed-Methods Study

    ERIC Educational Resources Information Center

    Le Patner, Michelle B.

    2012-01-01

    This study examined the American Recovery and Reinvestment Act federal mandate of the Transformation Intervention Model (TIM) outlined by the School Improvement Grant, which was designed to turn around persistently lowest achieving schools. The study was conducted in four high schools in a large Southern California urban district that selected the…

  4. Balancing Dreams and Realities: The College Choice Process for High-Achieving Latinas

    ERIC Educational Resources Information Center

    Hernández, Ebelia

    2015-01-01

    This study's narratives of 17 high-achieving Latinas revealed how their college choice was a constant balancing of individual and family expectations, being "close, but far enough away," and "getting your money's worth." With the use of critical race theory, further analysis revealed the influence of "familismo" on…

  5. Fostering the Promise of High Achieving Mathematics Students through Curriculum Differentiation

    ERIC Educational Resources Information Center

    Zmood, Simone

    2014-01-01

    Recent research suggests some teachers may not have a wide range of teaching and learning strategies for their most proficient mathematics students, which could impact on these students' learning and ongoing improvement in performance. This paper outlines the different drivers of high achievement and explores the main curriculum differentiation…

  6. Being Labeled "Nerd": Factors that Influence the Social Acceptance of High-Achieving Students

    ERIC Educational Resources Information Center

    Rentzsch, Katrin; Schutz, Astrid; Schroder-Abe, Michela

    2011-01-01

    The present investigation addresses the question of whether certain factors can protect high-achieving students at risk for being labeled a nerd against devaluation. In 2 studies, 125 and 317 students from Grade 8 evaluated vignettes describing average students and students who were called "nerds." Results indicate that being modest…

  7. Conflicts and Communication between High-Achieving Chinese American Adolescents and Their Parents

    ERIC Educational Resources Information Center

    Qin, Desiree Baolian; Chang, Tzu-Fen; Han, Eun-Jin; Chee, Grace

    2012-01-01

    Drawing on in-depth interview data collected on 18 high-achieving Chinese American students, the authors examine domains of acculturation-based conflicts, parent and child internal conflicts, and conflict resolution in their families. Their analyses show that well-established negative communication patterns in educational expectations, divergent…

  8. The College-Choice Process of High Achieving Freshmen: A Comparative Case Study

    ERIC Educational Resources Information Center

    Dale, Amanda

    2010-01-01

    The purpose of this study was to examine the college-choice process of high achieving students. Employing current literature and previous research, it combined current models of college choice and the influential factors identified throughout the literature while utilizing the concept of bounded rationality to create a conceptual framework to…

  9. Examining the Relationship between Selected Variables and the Academic Achievement of African American High School Students

    ERIC Educational Resources Information Center

    Graham, David Mark

    2009-01-01

    Research investigating the impact of factors such as gender, socioeconomic status, racial socialization, and academic self-concept on the academic achievement of African American high school students has been of interest to scholars for decades. Previous literature has focused much attention on the relationship of each of these constructs and…

  10. The Transition Experiences of High-Achieving, Low-Income Undergraduates in an Elite College Environment

    ERIC Educational Resources Information Center

    McLoughlin, Paul J., II

    2012-01-01

    This hermeneutic phenomenological study describes the lived experiences of high-achieving, low-income undergraduates and their transition into a college environment historically reserved for wealthy students. The results of this study indicate that these students are flourishing in full need-based financial aid programs as a result of their own…

  11. Examining the Predictive Power of Autonomy and Self-Evaluation on High School Students' Language Achievement

    ERIC Educational Resources Information Center

    Yuksel, Ismail; Toker, Yalcin

    2013-01-01

    This study aims to determine language learners' autonomy, self-evaluation levels and to examine the predictive power of these two variables on language achievement. The study was designed as mixed method design and was conducted with 108 high school students. Data were collected through an autonomy scale, a self-evaluation scale, schools record on…

  12. Mathematics Attitudes and Achievement of U.S. High School Sophomores Based on Race

    ERIC Educational Resources Information Center

    Martinez, James

    2017-01-01

    What are high school students thinking? The purpose of this study was to examine the degree that psychosocial attitudes affect academic achievement in mathematics for students of different races during secondary schooling. Based on a quantitative methodology, data was gathered from a nationally distributed survey involving over 16,000 student…

  13. The Effects of Alcohol Use on Academic Achievement in High School

    ERIC Educational Resources Information Center

    Balsa, Ana I.; Giuliano, Laura M.; French, Michael T.

    2011-01-01

    This paper examines the effects of alcohol use on high school students' quality of learning. We estimate fixed-effects models using data from the National Longitudinal Study of Adolescent Health. Our primary measure of academic achievement is the student's grade point average (GPA) abstracted from official school transcripts. We find that…

  14. Growing into Equity: Professional Learning and Personalization in High-Achieving Schools

    ERIC Educational Resources Information Center

    Gleason, Sonia Caus; Gerzon, Nancy

    2013-01-01

    What makes a Title I school high-achieving, and what can we all learn from that experience? Professional learning and leadership that supports personalized instruction makes the difference, as captured in the ground-breaking research of authors Sonia Caus Gleason and Nancy Gerzon. This illuminating book shows how four outstanding schools are…

  15. Further Evidence of an Engagement-Achievement Paradox among U.S. High School Students

    ERIC Educational Resources Information Center

    Shernoff, David J.; Schmidt, Jennifer A.

    2008-01-01

    Achievement, engagement, and students' quality of experience were compared by racial and ethnic group in a sample of students (N = 586) drawn from 13 high schools with diverse ethnic and socioeconomic student populations. Using the Experience Sampling Method (ESM), 3,529 samples of classroom experiences were analyzed along with self-reported…

  16. Impact of Physical Environment on Academic Achievement of High School Youth.

    ERIC Educational Resources Information Center

    Burkhalter, Bettye B.

    1983-01-01

    To study the relationship of the physical environment to high school students' academic achievement, 60 students participated in an experiential career exploration program at the Alabama Space and Rocket Center while 108 students participated in a traditional careers program. Tests indicated the former group improved more in career choice…

  17. Reliability and Validity Evidence for Achievement Goal Models in High School Physical Education Settings

    ERIC Educational Resources Information Center

    Guan, Jianmin; McBride, Ron; Xiang, Ping

    2007-01-01

    Although empirical research in academic areas provides support for both a 3-factor as well as a 4-factor achievement goal model, both models were proposed and tested with a collegiate sample. Little is known about the generalizability of either model with high school level samples. This study was designed to examine whether the 3-factor model…

  18. Antecedent and Concurrent Psychosocial Skills That Support High Levels of Achievement within Talent Domains

    ERIC Educational Resources Information Center

    Olszewski-Kubilius, Paula; Subotnik, Rena F.; Worrell, Frank C.

    2015-01-01

    Motivation and emotional regulation are important for the sustained focused study and practice required for high levels of achievement and creative productivity in adulthood. Using the talent development model proposed by the authors as a framework, the authors discuss several important psychosocial skills based on the psychological research…

  19. How High-Achieving African American Undergraduate Men Negotiate Cultural Challenges at a Predominantly White Institution

    ERIC Educational Resources Information Center

    Bradley, Elva Elaine

    2010-01-01

    In this study I examine the manner in which high-achieving African American undergraduate men negotiate cultural challenges in a predominantly White institution (PWI). Cultural theory underpins the conceptual framework of this case study. Basing the study in cultural theory provided a lens through which to view the lived experiences of the twenty…

  20. Central American Refugees and U.S. High Schools. A Psychosocial Study of Motivation and Achievement.

    ERIC Educational Resources Information Center

    Suarez-Orozco, Marcelo M.

    This ethnographic study documents and interprets key school, work, and family life issues in the lives and experiences of a sampling of recent immigrants from the war-torn Central American nations; and suggests a psychocultural theory of achievement motivation. Information was gathered from observation in two urban high schools, interviews with 50…

  1. The Impact of Inclusion on the Academic Achievement of High School Special Education Students

    ERIC Educational Resources Information Center

    Dawkins, Harold Smith

    2010-01-01

    This dissertation examined the impact of inclusion on the academic achievement outcome of high school special education students as measured by English 1, biology, and algebra 1 as a function of gender, ethnicity, and years of inclusion. The study also examined the generalizations with confidence that could be made about the use of inclusion…

  2. Experiencing More Mathematics Anxiety than Expected? Contrasting Trait and State Anxiety in High Achieving Students

    ERIC Educational Resources Information Center

    Roos, A.-L.; Bieg, M.; Goetz, T.; Frenzel, A. C.; Taxer, J.; Zeidner, M.

    2015-01-01

    This study examined mathematics anxiety among high and low achieving students (N = 237, grades 9 and 10) by contrasting trait (habitual) and state (momentary) assessments of anxiety. Previous studies have found that trait anxiety measures are typically rated higher than state measures. Furthermore, the academic self-concept has been identified to…

  3. High-Stakes Testing and Student Achievement: Updated Analyses with NAEP Data

    ERIC Educational Resources Information Center

    Nichols, Sharon L.; Glass, Gene V.; Berliner, David C.

    2012-01-01

    The present research is a follow-up study of earlier published analyses that looked at the relationship between high-stakes testing pressure and student achievement in 25 states. Using the previously derived Accountability Pressure Index (APR) as a measure of state-level policy pressure for performance on standardized tests, a series of…

  4. Standardized Tests as Measurements of Achievement: Does the High School Assessment Program (HSAP) Measure Up?

    ERIC Educational Resources Information Center

    Ray, Susan Amanda

    2008-01-01

    Purpose: The purpose of this study was to determine the correlation between HSAP scores and various measures of classroom achievement such as overall GPA, End Of Course Scores and SAT/ACT scores of Berea High School [BHS] students in the classes of 2005-2006 and 2006-2007. Methodology: The researcher collected the following data for random samples…

  5. Brain Structure and Resting-State Functional Connectivity in University Professors with High Academic Achievement

    ERIC Educational Resources Information Center

    Li, Weiwei; Yang, Wenjing; Li, Wenfu; Li, Yadan; Wei, Dongtao; Li, Huimin; Qiu, Jiang; Zhang, Qinglin

    2015-01-01

    Creative persons play an important role in technical innovation and social progress. There is little research on the neural correlates with researchers with high academic achievement. We used a combined structural (regional gray matter volume, rGMV) and functional (resting-state functional connectivity analysis, rsFC) approach to examine the…

  6. Ugandan Immigrant Students' Perceptions of Barriers to Academic Achievement in American High Schools

    ERIC Educational Resources Information Center

    Ssekannyo, Denis

    2010-01-01

    In a world that is now a global village, enterprising individuals, especially from Third World countries, who make it to greener pastures do not leave their children behind. But with a long list of barriers to academic achievement associated with immigrant and minority students in American high schools, an understanding of the experiences and…

  7. Students' High School Organizational Leadership Opportunities and Their Influences on Academic Achievement and Civic Participation

    ERIC Educational Resources Information Center

    Elemen, Jennifer E.

    2015-01-01

    The purpose of this quantitative study was to analyze high school leadership praxis for its inclusion of students in organizational leadership dialogue and decision-making and the influences of these factors on student achievement and civic participation. Survey questionnaire data were provided by 215 full-time enrolled undergraduate students from…

  8. Achievement, School Integration, and Self-Efficacy in Single-Sex and Coeducational Parochial High Schools

    ERIC Educational Resources Information Center

    Micucci, Kara Hanson

    2014-01-01

    A structural model for prior achievement, school integration, and self-efficacy was developed using Tinto's theory of student attrition and Bandura's self-efficacy theory. The model was tested and revised using a sample of 1,452 males and females from single-sex and coeducational parochial high schools. Results indicated that the theoretically…

  9. The Relationship between Illinois School District Superintendent Longevity and High School Student Achievement

    ERIC Educational Resources Information Center

    Libka, Robert J.

    2012-01-01

    Frequent changes in school district superintendents may be having a detrimental impact on student achievement. Rapid changes in leadership today parallel the present (NCLB) era of high stakes state assessments. The goal of the study was to provide correlation research that would have a positive effect on school district management, superintendent…

  10. Effect of Textbook Readability on Student Achievement in High School Chemistry.

    ERIC Educational Resources Information Center

    Rapp, D. Neil

    2001-01-01

    Notes the readability level of many high school chemistry textbooks is far above students' reading levels. Conducts two separate studies, making every effort to keep the two classes as similar as possible in all aspects except text. Finds strong evidence that changing the chemistry textbook resulted in an increase in student achievement. Suggests…

  11. Negative Relationship between Achievement in High School and Self-Concept in College.

    ERIC Educational Resources Information Center

    Wolfe, Raymond N.; Grosch, James W.

    Social learning theory implies that there should be a significant positive relationship between academic performance and self-concept and outcomes of recent meta-analyses support this prediction. While path-analytic studies of high school samples in the 1960s and 1970s demonstrated that ability and achievement each made a small positive…

  12. The Impact of Reading Success Academy on High School Reading Achievement

    ERIC Educational Resources Information Center

    Burlison, Kelly; Chave, Josh

    2014-01-01

    The study explores the effectiveness of the Reading Success Academy on the reading achievement of the selected group of ninth-grade students in a comprehensive high school. We examine in what ways the Reading Success Academy may improve the reading proficiency rates and amount of reading growth of ninth-grade students. The results indicate that…

  13. Black High Achieving Undergraduate Mathematics Majors Discuss Success and Persistence in Mathematics

    ERIC Educational Resources Information Center

    Ellington, Roni M.; Frederick, Rona

    2010-01-01

    Experiences of eight Black high-achieving college junior and senior mathematics majors are examined to discern which social and cultural factors shape success and persistence in mathematics. College persistence literature as well as mathematics education studies that document Black students' success in mathematics were used as frameworks to…

  14. Teaching Practices in Grade 5 Mathematics Classrooms with High-Achieving English Learner Students

    ERIC Educational Resources Information Center

    Merritt, Eileen G.; Palacios, Natalia; Banse, Holland; Rimm-Kaufman, Sara E.; Leis, Micela

    2017-01-01

    Teachers need more clarity about effective teaching practices as they strive to help their low-achieving students understand mathematics. Our study describes the instructional practices used by two teachers who, by value-added metrics, would be considered "highly effective teachers" in classrooms with a majority of students who were…

  15. One-to-One Computing and Student Achievement in Ohio High Schools

    ERIC Educational Resources Information Center

    Williams, Nancy L.; Larwin, Karen H.

    2016-01-01

    This study explores the impact of one-to-one computing on student achievement in Ohio high schools as measured by performance on the Ohio Graduation Test (OGT). The sample included 24 treatment schools that were individually paired with a similar control school. An interrupted time series methodology was deployed to examine OGT data over a period…

  16. Emotional Intelligence and Academic Achievement of High School Students in Kanyakumari District

    ERIC Educational Resources Information Center

    Lawrence, A. S. Arul; Deepa, T.

    2013-01-01

    The objective of the study is to find the significant relationship between emotional intelligence and academic achievement of high school students with reference to the background variables. Survey method was employed. Two tools are used in this study namely self-made Trait Emotional Intelligence Questionnaire Short Form (TEIQue SF) and the…

  17. Integrating Economic and Social Policy: Good Practices from High-Achieving Countries. Innocenti Working Papers.

    ERIC Educational Resources Information Center

    Mehrotra, Santosh

    This paper examines the successes of 10 "high achievers," countries with social indicators far higher than might be expected, given their national wealth, pulling together the lessons learned for social policy in the developing world. The 10 countries identified are Costa Rica, Cuba, Barbados, Botswana, Zimbabwe, Mauritius, Kerala, Sri…

  18. Spatial Experiences of High Academic Achievers: Insights from a Developmental Perspective

    ERIC Educational Resources Information Center

    Weckbacher, Lisa Marie; Okamoto, Yukari

    2012-01-01

    The study explored the relationship between types of spatial experiences and spatial abilities among 13- to 14-year-old high academic achievers. Each participant completed two spatial tasks and a survey assessing favored spatial activities across five categories (computers, toys, sports, music, and art) and three developmental periods (early…

  19. The Impact of High School Size on Math Achievement and Dropout Rate

    ERIC Educational Resources Information Center

    Werblow, Jacob; Duesbery, Luke

    2009-01-01

    The study explores the ways in which school size influences two important student outcomes commonly used in school effects research: growth in mathematics achievement and dropout rate. Past research suggests that smaller high schools can lead to increased benefits for students. In this study, multilevel analytic models of the first two waves of…

  20. Filial Piety and Academic Motivation: High-Achieving Students in an International School in South Korea

    ERIC Educational Resources Information Center

    Tam, Jonathan

    2016-01-01

    This study uses self-determination theory to explore the mechanisms of filial piety in the academic motivation of eight high-achieving secondary school seniors at an international school in South Korea, resulting in several findings. First, the students attributed their parents' values and expectations as a major source of the students'…

  1. Obesity, High-Calorie Food Intake, and Academic Achievement Trends among U.S. School Children

    ERIC Educational Resources Information Center

    Li, Jian; O'Connell, Ann A.

    2012-01-01

    The authors investigated children's self-reported high-calorie food intake in Grade 5 and its relationship to trends in obesity status and academic achievement over the first 6 years of school. They used 3-level hierarchical linear models in the large-scale database (the Early Childhood Longitudinal Study--Kindergarten Cohort). Findings indicated…

  2. Teachers and Student Achievement in the Chicago Public High Schools. WP 2002-28. Revised

    ERIC Educational Resources Information Center

    Aaronson, Daniel; Barrow, Lisa; Sander, William

    2003-01-01

    Using unique administrative data on Chicago public high school students and their teachers, we are able to estimate the importance of teachers on student mathematical achievement. We find that teachers are educationally and statistically important. To be sure, sampling variation and other measurement issues can strongly influence estimates of…

  3. Social Media Use, Loneliness, and Academic Achievement: A Correlational Study with Urban High School Students

    ERIC Educational Resources Information Center

    Neto, Roque; Golz, Nancy; Polega, Meaghan

    2015-01-01

    This study explored the association between social media use, loneliness, and academic achievement in high school students and identified the demographic characteristics associated with these three elements. This study also aimed to identify the percentage of variance in loneliness accounted for by social media use and GPA. Participants were 345…

  4. Actively Closing the Gap? Social Class, Organized Activities, and Academic Achievement in High School

    ERIC Educational Resources Information Center

    Morris, David S.

    2015-01-01

    Participation in Organized Activities (OA) is associated with positive behavioral and developmental outcomes in children. However, less is known about how particular aspects of participation affect the academic achievement of high school students from different social class positions. Using the Education Longitudinal Study of 2002, this study…

  5. Turkish High School Students' Biology Achievement in Relation to Academic Self-Regulation

    ERIC Educational Resources Information Center

    Yumusak, Necmettin; Sungur, Semra; Cakiroglu, Jale

    2007-01-01

    This study aimed at investigating the contribution of motivational beliefs, cognitive, and metacognitive strategy use to Turkish high school students' achievement in biology. In order to investigate the specified purpose of the study, 519 tenth-grade students were administered the Motivated Strategies for Learning Questionnaire (Pintrich, Smith,…

  6. Communication Satisfaction, Organizational Citizenship Behavior and the Relationship to Student Achievement in High Schools

    ERIC Educational Resources Information Center

    Blanchard, Gayle A.

    2012-01-01

    This study used a correlational design that allowed the researcher to examine the relationship among communication satisfaction, organizational citizenship behaviors (OCB) and student achievement. High school teachers were surveyed from a convenience sample of 12 school districts in Arizona. Established instruments were used to survey teachers'…

  7. Consequences of the Confucian Culture: High Achievement but Negative Psychological Attributes?

    ERIC Educational Resources Information Center

    Ho, Irene T.; Hau, Kit-Tai

    2010-01-01

    In "Unforgiving Confucian culture: A breeding ground for high academic achievement, test anxiety and self-doubt?" Stankov (in press) provides three reasons for caution against over-glorifying the academic excellence of Confucian Asian learners, namely that it may lead to a reluctance to change their rote learning approach which is not conducive to…

  8. Evaluative and Behavioral Correlates to Intrarehearsal Achievement in High School Bands

    ERIC Educational Resources Information Center

    Montemayor, Mark

    2014-01-01

    The purpose of this study was to investigate relationships of teaching effectiveness, ensemble performance quality, and selected rehearsal procedures to various measures of intrarehearsal achievement (i.e., musical improvement exhibited by an ensemble during the course of a single rehearsal). Twenty-nine high school bands were observed in two…

  9. Faculty Perceptions of High-Achieving Male Collegians: A Critical Race Theory Analysis

    ERIC Educational Resources Information Center

    Comeaux, Eddie

    2013-01-01

    Critical race theory was employed as an interpretive framework to explore faculty perceptions of the academic accomplishments of high-achieving Black and White male collegians. Using photo elicitation methodology, faculty participants responded to a randomly assigned photograph of and vignette about either a Black or White male student. While most…

  10. Self-Graded and Teacher-Graded Achievement in a BSCS High School Biology Course.

    ERIC Educational Resources Information Center

    Good, Wallace Martin

    The effect of self-grading on biology students exposed to the same instruction (except grading) in an upper-middle class public school was investigated by comparing self-graded and teacher-graded populations in (1) achievement in high school biology, (2) level of aspiration behavior, (3) critical thinking skills, and (4) productivity. The…

  11. Cognitive Abilities and Motivational Processes in High School Students' Situational Engagement and Achievement in Science.

    ERIC Educational Resources Information Center

    Lau, Shun; Roeser, Robert W.

    2002-01-01

    Building on R. Snow's two pathways to achievement outcomes (1989), examined how cognitive and motivational factors associated with the performance and commitment pathways respectively contributed to prediction of outcomes in science for 491 high school students. Results are consistent with Snow's conjecture that factors related to both pathways…

  12. Overall Findings: Common Practices and Procedures across Schools. High Achieving Schools Study. Synthesis Report

    ERIC Educational Resources Information Center

    Mohajeri-Nelson, Nazanin; Bamberry, Lynn; Dunaway, Wendy; Hunter, Ellen; Klein, Jeff; Kuntz, Courtney; Negley, Tina; Singer, Robin; Ottenbreit, Rebekah; Young, Eric

    2015-01-01

    This report summarizes the factors that were commonly noted across five high achieving elementary schools in Colorado: (1) Burlington; (2) Canyon Creek; (3) Soaring Eagles; (4) South Lakewood; and (5) Tavelli. After 10 days of onsite visits to participating schools, noteworthy commonalities surfaced across the schools. Policies, practices, and…

  13. Solution structure studies of monomeric human TIP47/perilipin-3 reveal a highly extended conformation

    PubMed Central

    Hynson, Robert M. G.; Jeffries, Cy M.; Trewhella, Jill; Cocklin, Simon

    2012-01-01

    Tail-interacting protein of 47 kDa (TIP47) has two putative functions: lipid biogenesis and mannose 6-phosphate receptor recycling. Progress in understanding the molecular details of these two functions has been hampered by the lack of structural data on TIP47, with a crystal structure of the C-terminal domain of the mouse homologue constituting the only structural data in the literature so far. Our studies have first provided a strategy to obtain pure monodisperse preparations of the full-length TIP47/perilipin-3 protein, as well as a series of N-terminal truncation mutants with no exogenous sequences. These constructs have then enabled us to obtain the first structural characterization of the full-length protein in solution. Our work demonstrates that the N-terminal region of TIP47/perilipin-3, in contrast to the largely helical C-terminal region, is predominantly β-structure with turns and bends. Moreover, we show that full-length TIP47/perilipin-3 adopts an extended conformation in solution, with considerable spatial separation of the N- and C-termini that would likely translate into a separation of functional domains. PMID:22508559

  14. Conformal Surface Coatings to Enable High Volume Expansion Li-Ion Anode Materials

    DTIC Science & Technology

    2010-07-12

    the formation of a metastable amor - phous alloy, sustaining up to 4.4 Li+ per Si.[2] Transition metal oxides undergo a conversion reaction at lower...necessary to achieve good cycling stability. If carbother- mal reduction to MoO3y during the electrode pre-heat treat- ment is observed, it suggests

  15. High Expectations--High Achievement on Literacy: "What Shall We Do in This Hangman's Hour?"

    ERIC Educational Resources Information Center

    Linnakyla, Pirjo

    Finland is a country of great expectations on literacy and literacy education. High expectations and demands have, however, a darker side. High expectations of society, parents, and teachers may have an effect on the students' self-esteem. The economic recession in the early 1990s strongly accelerated the change in literacy demands and…

  16. Cultivating a Growth Mindset in Students at a High-Achieving High School

    ERIC Educational Resources Information Center

    Fegley, Alan D.

    2010-01-01

    The purpose of this EPP is to develop a plan for changing the mindset of a large number of Haddonfield Memorial High School (HMHS) students from a fixed mindset to a growth mindset. HMHS is by most conventional measures a high performing school. Typically 100% of the students graduate with 96% of the students attending two or four year colleges…

  17. No More 1s: High Expectations Can Lead to High Achievement

    ERIC Educational Resources Information Center

    Cervone, Laureen; DiMartino, Lisa; Kerr, Kris

    2010-01-01

    The school district in Middletown, New York, in the state's Orange County, today serves close to 7,000 students in four elementary schools, two middle schools, and one high school. The district is classified by the state in the highest of three Need-to-Resource-Capacity groups, an urban or suburban school district with high student needs in…

  18. Examining the Success Factors of High-Achieving Puerto Rican Male High-School Students

    ERIC Educational Resources Information Center

    Garrett, Tomas; Antrop-Gonzalez, Rene; Velez, William

    2010-01-01

    This article works to dispel the myth that Latino urban high-school students are not capable of performing at high academic levels. Whereas much educational research emphasizes the academic underachievement of urban Latino students, this article counteracts this research by describing the four success factors that three working-class Puerto Rican…

  19. Conforming with current regulation in Turkey regarding the freezing of oocytes: A case report of the first pregnancy in Turkey achieved through oocyte vitrification

    PubMed Central

    Kahraman, Semra; Ulker, Kahraman; Pirkevi Çetinkaya, Caroline; Kumtepe Colakoglu, Yesim; Yelke, Hakan K.; Yilanlioglu, Cihangir

    2017-01-01

    Objectives: To present the first pregnancy achieved in Turkey with frozen–warmed oocytes in a case with previous nine unsuccessful assisted reproductive technology (ART) attempts. Methods: The clinical follow-up of a 33-year-old female applying to our ART centre after a long and complicated history of infertility is described. Results: In April 2013, the woman attempted our centre for her 10th ART trial. She informed us on oocyte pick-up (OPU) day that her husband had been hospitalized following a car crush in Albania and was unable to travel to our clinic to give a sperm sample. We were therefore placed in the position of having to make an emergency decision. OPU was done and seven oocytes were retrieved. Six metaphase II (MII) oocytes out of seven Cumulus Oocyte Complexes (COCs) were vitrified using the Kitazato Vitrification Cryotop Kit. Six months later, in November 2013, the patient applied for transfer. Two blastocysts were transferred and the ART trial resulted with a singleton pregnancy and the birth of a healthy new-born at term via cesarean section. Conclusion: Regulation Codes on Assisted Reproductive Procedures and Assisted Reproductive Technology Centres, published in the Official Gazette of the Republic of Turkey, on 6 March 2010 forbade the freezing of gonad cells and tissues except when essential for medical reasons and stated that this would be specified later. However, the Regulation Codes published in the Official Gazette of the Republic of Turkey, on 30 September 2014 provided no further clarification. Unfortunately, the wording of the regulations did not specifically address this unexpected emergency situation. However, we saw our decision to cryopreserve the oocytes as a valid interpretation of the regulations, bearing in mind also the requirement that sperm and oocyte in the IVF process must be those of a married couple. Turkish medicolegal regulations should be revised to increase the chances of more women taking advantage of the procedure

  20. Multiplex and quantitative pathogen detection with high-resolution capillary electrophoresis-based single-strand conformation polymorphism.

    PubMed

    Hwang, Hee Sung; Shin, Gi Won; Chung, Boram; Na, Jeongkyeong; Jung, Gyoo Yeol

    2013-01-01

    Among the molecular diagnostic methods for bacteria-induced diseases, capillary electrophoresis-based single-strand conformation polymorphism (CE-SSCP) combined with 16S rRNA gene-specific PCR has enormous potential because it can separate sequence variants using a simple procedure. However, conventional CE-SSCP systems have limited resolution and cannot separate most 16S rRNA gene-specific markers into separate peaks. A high-resolution CE-SSCP system that uses a poly(ethyleneoxide)-poly(propyleneoxide)-poly(ethyleneoxide) triblock copolymer matrix was recently developed and shown to effectively separate highly similar PCR products. In this report, a protocol for the detection of 12 pathogenic bacteria is provided. Pathogen markers were amplified by PCR using universal primers and separated by CE-SSCP; each marker peak was well separated at baseline and showed a characteristic mobility, allowing the easy identification of the pathogens.

  1. General Conformity

    EPA Pesticide Factsheets

    The General Conformity requirements ensure that the actions taken by federal agencies in nonattainment and maintenance areas do not interfere with a state’s plans to meet national standards for air quality.

  2. Conformal Infinity

    NASA Astrophysics Data System (ADS)

    Frauendiener, Jörg

    2004-12-01

    The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, "conformal infinity" is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation, and how it lends itself very naturally to the solution of radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  3. Modeling stability of growth between mathematics and science achievement during middle and high school.

    PubMed

    Ma, Xin; Ma, Lingling

    2004-04-01

    In this study, the authors introduced a multivariate multilevel model to estimate the consistency among students and schools in the rates of growth between mathematics and science achievement during the entire middle and high school years with data from the Longitudinal Study of American Youth (LSAY). There was no evident consistency in the rates of growth between mathematics and science achievement among students, and this inconsistency was not much influenced by student characteristics and school characteristics. However, there was evident consistency in the average rates of growth between mathematics and science achievement among schools, and this consistency was influenced by student characteristics and school characteristics. Major school-level variables associated with parental involvement did not show any significant impacts on consistency among either students or schools. Results call for educational policies that promote collaboration between mathematics and science departments or teachers.

  4. Relationship of constructivist learning environment to student attitudes and achievement in high school mathematics and science

    NASA Astrophysics Data System (ADS)

    Dethlefs, Theresa Marie

    This study investigated the relationship of constructivist learning environment and standards-based teaching practices to student achievement and attitudes (self-efficacy, intrinsic value, and learning strategies) in Algebra and Biology. Further, these relationships were examined as a function of student gender and prior achievement. A purposive sample of 804 high school students enrolled in Biology I, Algebra I, or Advanced Algebra was selected for inclusion in this study. Although the dimensions of constructivist learning environment that contributed to predicting student achievement and attitudes varied by content area and criterion, the results of the present study generally provide strong support for a positive relationship between constructivist learning environment and student attitudes, but little support for a direct relationship to student achievement. Teacher reports of overall constructivist learning environment were not correlated with achievement or attitudes. Observer reports of constructivist learning environment were correlated with student intrinsic value and learning strategies. Student reports of constructivist learning environment were correlated with all three attitude measures. Multiple regression findings showed that neither overall constructivist learning environment nor standards-based teaching practices predicted achievement in any of the content areas. Overall constructivist learning environment and standards-based teaching practices were significant positive predictors of student intrinsic value and learning strategies in all three content areas, after controlling for student and classroom demographic variables. Overall constructivist learning environment and standards-based teaching practices were also significant positive predictors of self-efficacy in Algebra 1. In addition, standards-based teaching practices was a significant positive predictor of student self-efficacy in Biology. No specific dimensions of constructivist learning

  5. Peace of Mind, Academic Motivation, and Academic Achievement in Filipino High School Students.

    PubMed

    Datu, Jesus Alfonso D

    2017-04-09

    Recent literature has recognized the advantageous role of low-arousal positive affect such as feelings of peacefulness and internal harmony in collectivist cultures. However, limited research has explored the benefits of low-arousal affective states in the educational setting. The current study examined the link of peace of mind (PoM) to academic motivation (i.e., amotivation, controlled motivation, and autonomous motivation) and academic achievement among 525 Filipino high school students. Findings revealed that PoM was positively associated with academic achievement β = .16, p < .05, autonomous motivation β = .48, p < .001, and controlled motivation β = .25, p < .01. As expected, PoM was negatively related to amotivation β = -.19, p < .05, and autonomous motivation was positively associated with academic achievement β = .52, p < .01. Furthermore, the results of bias-corrected bootstrap analyses at 95% confidence interval based on 5,000 bootstrapped resamples demonstrated that peace of mind had an indirect influence on academic achievement through the mediating effects of autonomous motivation. In terms of the effect sizes, the findings showed that PoM explained about 1% to 18% of the variance in academic achievement and motivation. The theoretical and practical implications of the results are elucidated.

  6. The role of chronotype, gender, test anxiety, and conscientiousness in academic achievement of high school students.

    PubMed

    Rahafar, Arash; Maghsudloo, Mahdis; Farhangnia, Sajedeh; Vollmer, Christian; Randler, Christoph

    2016-01-01

    Previous findings have demonstrated that chronotype (morningness/intermediate/eveningness) is correlated with cognitive functions, that is, people show higher mental performance when they do a test at their preferred time of day. Empirical studies found a relationship between morningness and higher learning achievement at school and university. However, only a few of them controlled for other moderating and mediating variables. In this study, we included chronotype, gender, conscientiousness and test anxiety in a structural equation model (SEM) with grade point average (GPA) as academic achievement outcome. Participants were 158 high school students and results revealed that boys and girls differed in GPA and test anxiety significantly, with girls reporting better grades and higher test anxiety. Moreover, there was a positive correlation between conscientiousness and GPA (r = 0.17) and morningness (r = 0.29), respectively, and a negative correlation between conscientiousness and test anxiety (r = -0.22). The SEM demonstrated that gender was the strongest predictor of academic achievement. Lower test anxiety predicted higher GPA in girls but not in boys. Additionally, chronotype as moderator revealed a significant association between gender and GPA for evening types and intermediate types, while intermediate types showed a significant relationship between test anxiety and GPA. Our results suggest that gender is an essential predictor of academic achievement even stronger than low or absent test anxiety. Future studies are needed to explore how gender and chronotype act together in a longitudinal panel design and how chronotype is mediated by conscientiousness in the prediction of academic achievement.

  7. High fat diet promotes achievement of peak bone mass in young rats

    SciTech Connect

    Malvi, Parmanand; Piprode, Vikrant; Chaube, Balkrishna; Pote, Satish T.; Mittal, Monika; Chattopadhyay, Naibedya; Wani, Mohan R.; Bhat, Manoj Kumar

    2014-12-05

    Highlights: • High fat diet helps in achieving peak bone mass at younger age. • Shifting from high fat to normal diet normalizes obese parameters. • Bone parameters are sustained even after withdrawal of high fat diet. - Abstract: The relationship between obesity and bone is complex. Epidemiological studies demonstrate positive as well as negative correlation between obesity and bone health. In the present study, we investigated the impact of high fat diet-induced obesity on peak bone mass. After 9 months of feeding young rats with high fat diet, we observed obesity phenotype in rats with increased body weight, fat mass, serum triglycerides and cholesterol. There were significant increases in serum total alkaline phosphatase, bone mineral density and bone mineral content. By micro-computed tomography (μ-CT), we observed a trend of better trabecular bones with respect to their microarchitecture and geometry. This indicated that high fat diet helps in achieving peak bone mass and microstructure at younger age. We subsequently shifted rats from high fat diet to normal diet for 6 months and evaluated bone/obesity parameters. It was observed that after shifting rats from high fat diet to normal diet, fat mass, serum triglycerides and cholesterol were significantly decreased. Interestingly, the gain in bone mineral density, bone mineral content and trabecular bone parameters by HFD was retained even after body weight and obesity were normalized. These results suggest that fat rich diet during growth could accelerate achievement of peak bone mass that is sustainable even after withdrawal of high fat diet.

  8. Computer-Based Drill and Practice in Arithmetic: Widening the Gap between High- and Low-Achieving Students.

    ERIC Educational Resources Information Center

    Hativa, Nira

    1988-01-01

    The differential effects of computer-assisted instruction for high-achieving and low-achieving students were examined for seven elementary students of varied background. Higher-achieving students were more able to adjust to the requirements of computer work and to derive benefit from it than were lower-achieving students. Implications for teaching…

  9. Achievement Motivation of the High School Students: A Case Study among Different Communities of Goalpara District of Assam

    ERIC Educational Resources Information Center

    Sarangi, C.

    2015-01-01

    Achievement motivation is a consistent striving force of an individual to achieve success to a certain standard of excellence in competing situation. In this study an attempt was made to study the effect of achievement motivation on the academic achievement of the high school students of tribal and non tribal communities in relation to their sex…

  10. Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning.

    PubMed

    Ren, Jiyun; Menon, Geetha; Sloboda, Ron

    2013-04-07

    Although the Manchester system is still extensively used to prescribe dose in brachytherapy (BT) for locally advanced cervix cancer, many radiation oncology centers are transitioning to 3D image-guided BT, owing to the excellent anatomy definition offered by modern imaging modalities. As automatic dose optimization is highly desirable for 3D image-based BT, this study comparatively evaluates the performance of two optimization methods used in BT treatment planning--Nelder-Mead simplex (NMS) and simulated annealing (SA)--for a cervix BT computer simulation model incorporating a Manchester-style applicator. Eight model cases were constructed based on anatomical structure data (for high risk-clinical target volume (HR-CTV), bladder, rectum and sigmoid) obtained from measurements on fused MR-CT images for BT patients. D90 and V100 for HR-CTV, D2cc for organs at risk (OARs), dose to point A, conformation index and the sum of dwell times within the tandem and ovoids were calculated for optimized treatment plans designed to treat the HR-CTV in a highly conformal manner. Compared to the NMS algorithm, SA was found to be superior as it could perform optimization starting from a range of initial dwell times, while the performance of NMS was strongly dependent on their initial choice. SA-optimized plans also exhibited lower D2cc to OARs, especially the bladder and sigmoid, and reduced tandem dwell times. For cases with smaller HR-CTV having good separation from adjoining OARs, multiple SA-optimized solutions were found which differed markedly from each other and were associated with different choices for initial dwell times. Finally and importantly, the SA method yielded plans with lower dwell time variability compared with the NMS method.

  11. Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning

    NASA Astrophysics Data System (ADS)

    Ren, Jiyun; Menon, Geetha; Sloboda, Ron

    2013-04-01

    Although the Manchester system is still extensively used to prescribe dose in brachytherapy (BT) for locally advanced cervix cancer, many radiation oncology centers are transitioning to 3D image-guided BT, owing to the excellent anatomy definition offered by modern imaging modalities. As automatic dose optimization is highly desirable for 3D image-based BT, this study comparatively evaluates the performance of two optimization methods used in BT treatment planning—Nelder-Mead simplex (NMS) and simulated annealing (SA)—for a cervix BT computer simulation model incorporating a Manchester-style applicator. Eight model cases were constructed based on anatomical structure data (for high risk-clinical target volume (HR-CTV), bladder, rectum and sigmoid) obtained from measurements on fused MR-CT images for BT patients. D90 and V100 for HR-CTV, D2cc for organs at risk (OARs), dose to point A, conformation index and the sum of dwell times within the tandem and ovoids were calculated for optimized treatment plans designed to treat the HR-CTV in a highly conformal manner. Compared to the NMS algorithm, SA was found to be superior as it could perform optimization starting from a range of initial dwell times, while the performance of NMS was strongly dependent on their initial choice. SA-optimized plans also exhibited lower D2cc to OARs, especially the bladder and sigmoid, and reduced tandem dwell times. For cases with smaller HR-CTV having good separation from adjoining OARs, multiple SA-optimized solutions were found which differed markedly from each other and were associated with different choices for initial dwell times. Finally and importantly, the SA method yielded plans with lower dwell time variability compared with the NMS method.

  12. Solvent additive to achieve highly ordered nanostructural semicrystalline DPP copolymers: toward a high charge carrier mobility.

    PubMed

    An, Tae Kyu; Kang, Il; Yun, Hui-jun; Cha, Hyojung; Hwang, Jihun; Park, Seonuk; Kim, Jiye; Kim, Yu Jin; Chung, Dae Sung; Kwon, Soon-Ki; Kim, Yun-Hi; Park, Chan Eon

    2013-12-23

    A facile spin-coating method in which a small percentage of the solvent additive, 1-chloronaphthalene (CN), is found to increase the drying time during film deposition, is reported. The field-effect mobility of a PDPPDBTE film cast from a chloroform-CN mixed solution is 0.46 cm(2) V(-1) s(-1). The addition of CN to the chloroform solution facilitates the formation of highly crystalline polymer structures.

  13. Challenges to achievement of metal sustainability in our high-tech society

    SciTech Connect

    Izatt, Reed M.; Izatt, Steven R.; Bruening, Ronald L.; Izatt, Neil; Moyer, Bruce A

    2014-01-01

    Achievement of sustainability in metal life cycles from mining of virgin ore to consumer and industrial devices to end-of-life products requires greatly increased recycling and improved processing of metals. Electronic and other high-tech products containing precious, toxic, and specialty metals usually have short lifetimes and low recycling rates. Products containing these metals generally are incinerated, discarded as waste in landfills, or dismantled in informal recycling using crude and environmentally irresponsible procedures. Low metal recycling rates coupled with increasing demand for products containing them necessitate increased mining with attendant environmental, health, energy, water, and carbon-footprint consequences. In this tutorial review, challenges to achieving metal sustainability in present high-tech society are presented; health, environmental, and economic incentives for various stakeholders to improve metal sustainability are discussed; a case for technical improvements in separations technology, especially employing molecular recognition, is given; and global consequences of continuing on the present path are examined.

  14. Achieving High Pressure Shock Hugoniot Measurements in Cylindrical Geometry Utilizing a High-Explosive Pulsed Power Drive

    DTIC Science & Technology

    2011-06-01

    to conduct high velocity material experiments and measure shock velocities at pressures near 1 TPa. The DEMG (Disk Explosive Magnetic Generator ... Explosive Magnetic Generator ) will be able to achieve extremely high currents with as much as 70 MA usable for driving a z-pinch experiment. In this...shock velocities at pressures near 1 TPa. The DEMG (Disk Explosive Magnetic Generator ) is used to drive a >60MA current that accelerates an aluminum

  15. The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence

    PubMed Central

    Krapohl, Eva; Rimfeld, Kaili; Shakeshaft, Nicholas G.; Trzaskowski, Maciej; McMillan, Andrew; Pingault, Jean-Baptiste; Asbury, Kathryn; Harlaar, Nicole; Kovas, Yulia; Dale, Philip S.; Plomin, Robert

    2014-01-01

    Because educational achievement at the end of compulsory schooling represents a major tipping point in life, understanding its causes and correlates is important for individual children, their families, and society. Here we identify the general ingredients of educational achievement using a multivariate design that goes beyond intelligence to consider a wide range of predictors, such as self-efficacy, personality, and behavior problems, to assess their independent and joint contributions to educational achievement. We use a genetically sensitive design to address the question of why educational achievement is so highly heritable. We focus on the results of a United Kingdom-wide examination, the General Certificate of Secondary Education (GCSE), which is administered at the end of compulsory education at age 16. GCSE scores were obtained for 13,306 twins at age 16, whom we also assessed contemporaneously on 83 scales that were condensed to nine broad psychological domains, including intelligence, self-efficacy, personality, well-being, and behavior problems. The mean of GCSE core subjects (English, mathematics, science) is more heritable (62%) than the nine predictor domains (35–58%). Each of the domains correlates significantly with GCSE results, and these correlations are largely mediated genetically. The main finding is that, although intelligence accounts for more of the heritability of GCSE than any other single domain, the other domains collectively account for about as much GCSE heritability as intelligence. Together with intelligence, these domains account for 75% of the heritability of GCSE. We conclude that the high heritability of educational achievement reflects many genetically influenced traits, not just intelligence. PMID:25288728

  16. The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence.

    PubMed

    Krapohl, Eva; Rimfeld, Kaili; Shakeshaft, Nicholas G; Trzaskowski, Maciej; McMillan, Andrew; Pingault, Jean-Baptiste; Asbury, Kathryn; Harlaar, Nicole; Kovas, Yulia; Dale, Philip S; Plomin, Robert

    2014-10-21

    Because educational achievement at the end of compulsory schooling represents a major tipping point in life, understanding its causes and correlates is important for individual children, their families, and society. Here we identify the general ingredients of educational achievement using a multivariate design that goes beyond intelligence to consider a wide range of predictors, such as self-efficacy, personality, and behavior problems, to assess their independent and joint contributions to educational achievement. We use a genetically sensitive design to address the question of why educational achievement is so highly heritable. We focus on the results of a United Kingdom-wide examination, the General Certificate of Secondary Education (GCSE), which is administered at the end of compulsory education at age 16. GCSE scores were obtained for 13,306 twins at age 16, whom we also assessed contemporaneously on 83 scales that were condensed to nine broad psychological domains, including intelligence, self-efficacy, personality, well-being, and behavior problems. The mean of GCSE core subjects (English, mathematics, science) is more heritable (62%) than the nine predictor domains (35-58%). Each of the domains correlates significantly with GCSE results, and these correlations are largely mediated genetically. The main finding is that, although intelligence accounts for more of the heritability of GCSE than any other single domain, the other domains collectively account for about as much GCSE heritability as intelligence. Together with intelligence, these domains account for 75% of the heritability of GCSE. We conclude that the high heritability of educational achievement reflects many genetically influenced traits, not just intelligence.

  17. Test of the Anti-de Sitter-Space/Conformal-Field-Theory Correspondence Using High-Spin Operators

    SciTech Connect

    Benna, M. K.; Benvenuti, S.; Klebanov, I. R.; Scardicchio, A.

    2007-03-30

    In two remarkable recent papers the planar perturbative expansion was proposed for the universal function of the coupling appearing in the dimensions of high-spin operators of the N=4 super Yang-Mills theory. We study numerically the integral equation derived by Beisert, Eden, and Staudacher, which resums the perturbative series. In a confirmation of the anti-de Sitter-space/conformal-field-theory (AdS/CFT) correspondence, we find a smooth function whose two leading terms at strong coupling match the results obtained for the semiclassical folded string spinning in AdS{sub 5}. We also make a numerical prediction for the third term in the strong coupling series.

  18. Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy

    PubMed Central

    Ngo, Kien Xuan; Kodera, Noriyuki; Katayama, Eisaku; Ando, Toshio; Uyeda, Taro QP

    2015-01-01

    High-speed atomic force microscopy was employed to observe structural changes in actin filaments induced by cofilin binding. Consistent with previous electron and fluorescence microscopic studies, cofilin formed clusters along actin filaments, where the filaments were 2-nm thicker and the helical pitch was ∼25% shorter, compared to control filaments. Interestingly, the shortened helical pitch was propagated to the neighboring bare zone on the pointed-end side of the cluster, while the pitch on the barbed-end side was similar to the control. Thus, cofilin clusters induce distinctively asymmetric conformational changes in filaments. Consistent with the idea that cofilin favors actin structures with a shorter helical pitch, cofilin clusters grew unidirectionally toward the pointed-end of the filament. Severing was often observed near the boundaries between bare zones and clusters, but not necessarily at the boundaries. DOI: http://dx.doi.org/10.7554/eLife.04806.001 PMID:25642645

  19. Motivational profiles in high school students: Differences in behavioural and emotional homework engagement and academic achievement.

    PubMed

    Regueiro, Bibiana; Núñez, José C; Valle, Antonio; Piñeiro, Isabel; Rodríguez, Susana; Rosário, Pedro

    2016-12-12

    This work examined whether combinations of academic and non-academic goals generated different motivational profiles in high school students. Besides, differences in homework behavioural engagement (i.e. amount of homework, time spent in homework, homework time management), homework emotional engagement (i.e. homework anxiety) and academic achievement were analysed. Participants were 714 high school students (43.4% boys and 56.6% girls). The study of potential motivational profiles was conducted by latent profile analysis, and the differences between the motivational profiles regarding homework variables and academic achievement were analysed using multivariate analysis. The results indicate the existence of five groups of motivational profiles: a group of students with multiple goals, a group of unmotivated students, two groups of students with a predominance of learning goals and, finally, a group comprising students with a high fear of failure. Both the group with multiple goals and the learning goals-oriented groups reported to do more homework, spending more time on homework, making better use of that time and having a higher academic achievement than counterparts. The avoidance-failure group and the group with multiple goals showed higher levels of homework anxiety. Globally, these results provide support for a person-centred approach.

  20. Family Processes, SES, and Family Structure Differentially Affect Academic Self-Concepts and Achievement of Gifted High School Students.

    ERIC Educational Resources Information Center

    Verna, Marilyn Ann; Campbell, James Reed; Beasley, Mark

    A study involving 109 male and 116 female high achieving high school students (ages 16-18) and their parents investigated the causal linkages among home environment, self-concepts, prior ability, and socioeconomic status on mathematics achievement, science achievement, and Scholastic Aptitude Test-Quantitative (SAT-Q) and Verbal scores. Students…

  1. Achieving high strength and high electrical conductivity in Ag/Cu multilayers

    NASA Astrophysics Data System (ADS)

    Wei, M. Z.; Xu, L. J.; Shi, J.; Pan, G. J.; Cao, Z. H.; Meng, X. K.

    2015-01-01

    In this work, we investigated the microstructure evolution of Ag/Cu multilayers and its influences on the hardness and electric resistivity with individual layer thickness (h) ranging from 3 to 50 nm. The hardness increases with the decreasing h in the range of 5-20 nm. The barrier to dislocation transmission by stacking faults, twin boundaries, and interfaces leads to hardness enhancement. Simultaneously, in order to get high conductivity, the strong textures in-layers were induced to form for reducing the amount of grain boundaries. The resistivity keeps low even when h decreases to 10 nm. Furthermore, we developed a facile model to evaluate the comprehensive property of Ag/Cu multilayers—the results indicate that the best combination of strength and conductivity occurs when h = 10 nm.

  2. Dry Blending to Achieve Isotopic Dilution of Highly Enriched Uranium Oxide Materials

    SciTech Connect

    Henry, Roger Neil; Chipman, Nathan Alan; Rajamani, R. K.

    2001-04-01

    The end of the cold war produced large amounts of excess fissile materials in the United States and Russia. The Department of Energy has initiated numerous activities to focus on identifying material management strategies for disposition of these excess materials. To date, many of these planning strategies have included isotopic dilution of highly enriched uranium as a means of reducing the proliferation and safety risks. Isotopic dilution by dry blending highly enriched uranium with natural and/or depleted uranium has been identified as one non-aqueous method to achieve these risk (proliferation and criticality safety) reductions. This paper reviews the technology of dry blending as applied to free flowing oxide materials.

  3. Progress toward achieving high power and high efficiency semipolar LEDs and their characterization

    NASA Astrophysics Data System (ADS)

    Zhong, Hong

    Performance of current commercially available wurtzite nitride based light-emitting diodes (LEDs), grown along the polar (0001) c-plane orientation, is limited by the presence of polarization-related electric fields inside multi-quantum wells (MQWs). The discontinuities in both spontaneous and piezoelectric polarization at the heterointerfaces result in internal electric fields in the quantum wells. These electric fields cause carrier separation [quantum confined Stark effect (QCSE)] and reduce the radiative recombination rate within the quantum wells. One approach to reduce and possibly eliminate the polarization-related effects is to grow III-nitride devices on crystal planes that are inclined with respect to the c-axis, i.e., on semipolar planes. In this dissertation, metalorganic chemical vapor deposition (MOCVD) has been employed for the homoepitaxial growth of GaN based LEDs on semipolar orientations. As a consequence of growing on high-quality bulk GaN substrates, the LEDs have significantly reduced threading dislocation and stacking fault densities, resulting in remarkable improvements in EQE and output power. High efficiency semipolar (1011) violet-blue and blue LEDs have been demonstrated without any intentional effort to enhance the light extraction from those devices. Optimizations of epitaxial structures have led to increased output power and external quantum efficiency. A silicone encapsulated single quantum well blue LED with peak wavelength of 444 nm with output power of 24.3 mW, external quantum efficiency of 43% and luminous efficacy of 75 lm/W (with phosphorescent coating) at 20 mA has been demonstrated. Polarization fields in strained (1011) and (112¯2) InGaN quantum wells have been experimentally determined through bias-dependent optical studies. Our results show that the polarization field flips its direction in semipolar InGaN quantum wells with large inclination angles (i.e. around 60°). This suggests that there exists a polarization

  4. High-Dose Conformal Radiotherapy Reduces Prostate Cancer-Specific Mortality: Results of a Meta-analysis

    SciTech Connect

    Viani, Gustavo Arruda; Godoi Bernardes da Silva, Lucas; Stefano, Eduardo Jose

    2012-08-01

    Purpose: To determine in a meta-analysis whether prostate cancer-specific mortality (PCSM), biochemical or clinical failure (BCF), and overall mortality (OM) in men with localized prostate cancer treated with conformal high-dose radiotherapy (HDRT) are better than those in men treated with conventional-dose radiotherapy (CDRT). Methods and Materials: The MEDLINE, Embase, CANCERLIT, and Cochrane Library databases, as well as the proceedings of annual meetings, were systematically searched to identify randomized, controlled studies comparing conformal HDRT with CDRT for localized prostate cancer. Results: Five randomized, controlled trials (2508 patients) that met the study criteria were identified. Pooled results from these randomized, controlled trials showed a significant reduction in the incidence of PCSM and BCF rates at 5 years in patients treated with HDRT (p = 0.04 and p < 0.0001, respectively), with an absolute risk reduction (ARR) of PCSM and BCF at 5 years of 1.7% and 12.6%, respectively. Two trials evaluated PCSM with 10 years of follow up. The pooled results from these trials showed a statistical benefit for HDRT in terms of PCSM (p = 0.03). In the subgroup analysis, trials that used androgen deprivation therapy (ADT) showed an ARR for BCF of 12.9% (number needed to treat = 7.7, p < 0.00001), whereas trials without ADT had an ARR of 13.6% (number needed to treat = 7, p < 0.00001). There was no difference in the OM rate at 5 and 10 years (p = 0.99 and p = 0.11, respectively) between the groups receiving HDRT and CDRT. Conclusions: This meta-analysis is the first study to show that HDRT is superior to CDRT in preventing disease progression and prostate cancer-specific death in trials that used conformational technique to increase the total dose. Despite the limitations of our study in evaluating the role of ADT and HDRT, our data show no benefit for HDRT arms in terms of BCF in trials with or without ADT.

  5. A Study of Gifted High, Moderate, and Low Achievers in Their Personal Characteristics and Attitudes toward School and Teachers

    ERIC Educational Resources Information Center

    Abu-Hamour, Bashir; Al-Hmouz, Hanan

    2013-01-01

    This study examines the problem of underachievement among gifted high school students. Low achievers were compared to high and moderate achievers on their motivation, self-regulation, and attitudes toward their school and teachers. Participants were all highly able students from grades 10 and 11 in an academically selective gifted high school in…

  6. High performances CNTFETs achieved using CNT networks for selective gas sensing

    NASA Astrophysics Data System (ADS)

    Gorintin, Louis; Bondavalli, Paolo; Legagneux, Pierre; Pribat, Didier

    2009-08-01

    Our study deals with the utilization of carbon nanotubes networks based transistors with different metal electrodes for highly selective gas sensing. Indeed, carbon nanotubes networks can be used as semi conducting materials to achieve good performances transistors. These devices are extremely sensitive to the change of the Schottky barrier heights between Single Wall Carbon Nanotubes (SWCNTs) and drain/source metal electrodes: the gas adsorption creates an interfacial dipole that modifies the metal work function and so the bending and the height of the Schottky barrier at the contacts. Moreover each gas interacts specifically with each metal identifying a sort of electronic fingerprinting. Using airbrush technique for deposition, we have been able to achieve uniform random networks of carbon nanotubes suitable for large area applications and mass production such as fabrication of CNT based gas sensors. These networks enable us to achieve transistors with on/off ratio of more than 5 orders of magnitude. To reach these characteristics, the density of the CNT network has been adjusted in order to reach the percolation threshold only for semi-conducting nanotubes. These optimized devices have allowed us to tune the sensitivity (improving it) of our sensors for highly selective detection of DiMethyl-Methyl-Phosphonate (DMMP, a sarin stimulant), and even volatile drug precursors using Pd, Au and Mo electrodes.

  7. Achieving High Spatial Resolution Surface Plasmon Resonance Microscopy with Image Reconstruction.

    PubMed

    Yu, Hui; Shan, Xiaonan; Wang, Shaopeng; Tao, Nongjian

    2017-03-07

    Surface plasmon resonance microscopy (SPRM) is a powerful platform for biomedical imaging and molecular binding kinetics analysis. However, the spatial resolution of SPRM along the plasmon propagation direction (longitudinal) is determined by the decaying length of the plasmonic wave, which can be as large as tens of microns. Different methods have been proposed to improve the spatial resolution, but each at the expense of decreased sensitivity or temporal resolution. Here we present a method to achieve high spatial resolution SPRM based on deconvolution of complex field. The method does not require additional optical setup and improves the spatial resolution in the longitudinal direction. We applied the method to image nanoparticles and achieved close-to-diffraction limit resolution in both longitudinal and transverse directions.

  8. Supercharging with m-nitrobenzyl alcohol and propylene carbonate: forming highly charged ions with extended, near-linear conformations.

    PubMed

    Going, Catherine C; Williams, Evan R

    2015-04-07

    The effectiveness of the supercharging reagents m-nitrobenzyl alcohol (m-NBA) and propylene carbonate at producing highly charged protein ions in electrospray ionization is compared. Addition of 5% m-NBA or 15% propylene carbonate increases the average charge of three proteins by ∼21% or ∼23%, respectively, when these ions are formed from denaturing solutions (water/methanol/acetic acid). These results indicate that both reagents are nearly equally effective at supercharging when used at their optimum concentrations. A narrowing of the charge state distribution occurs with both reagents, although this effect is greater for propylene carbonate. Focusing the ion signal into fewer charge states has the advantage of improving sensitivity. The maximum charge state of ubiquitin formed with propylene carbonate is 21+, four charges higher than previously reported. Up to nearly 30% of all residues in a protein can be charged, and the collisional cross sections of the most highly charged ions of both ubiquitin and cytochrome c formed with these supercharging reagents were measured for the first time and found to be similar to those calculated for theoretical highly extended, linear or near-linear conformations. Under native supercharging conditions, m-NBA is significantly more effective at producing high charge states than propylene carbonate.

  9. The effects of modeling instruction on high school physics academic achievement

    NASA Astrophysics Data System (ADS)

    Wright, Tiffanie L.

    The purpose of this study was to explore whether Modeling Instruction, compared to traditional lecturing, is an effective instructional method to promote academic achievement in selected high school physics classes at a rural middle Tennessee high school. This study used an ex post facto , quasi-experimental research methodology. The independent variables in this study were the instructional methods of teaching. The treatment variable was Modeling Instruction and the control variable was traditional lecture instruction. The Treatment Group consisted of participants in Physical World Concepts who received Modeling Instruction. The Control Group consisted of participants in Physical Science who received traditional lecture instruction. The dependent variable was gains scores on the Force Concepts Inventory (FCI). The participants for this study were 133 students each in both the Treatment and Control Groups (n = 266), who attended a public, high school in rural middle Tennessee. The participants were administered the Force Concepts Inventory (FCI) prior to being taught the mechanics of physics. The FCI data were entered into the computer-based Statistical Package for the Social Science (SPSS). Two independent samples t-tests were conducted to answer the research questions. There was a statistically significant difference between the treatment and control groups concerning the instructional method. Modeling Instructional methods were found to be effective in increasing the academic achievement of students in high school physics. There was no statistically significant difference between FCI gains scores for gender. Gender was found to have no effect on the academic achievement of students in high school physics classes. However, even though there was not a statistically significant difference, female students' gains scores were higher than male students' gains scores when Modeling Instructional methods of teaching were used. Based on these findings, it is recommended

  10. Achieving High Performance in AC-Field Driven Organic Light Sources

    PubMed Central

    Xu, Junwei; Carroll, David L.; Smith, Gregory M.; Dun, Chaochao; Cui, Yue

    2016-01-01

    Charge balance in organic light emitting structures is essential to simultaneously achieving high brightness and high efficiency. In DC-driven organic light emitting devices (OLEDs), this is relatively straight forward. However, in the newly emerging, capacitive, field-activated AC-driven organic devices, charge balance can be a challenge. In this work we introduce the concept of gating the compensation charge in AC-driven organic devices and demonstrate that this can result in exceptional increases in device performance. To do this we replace the insulator layer in a typical field-activated organic light emitting device with a nanostructured, wide band gap semiconductor layer. This layer acts as a gate between the emitter layer and the voltage contact. Time resolved device characterization shows that, at high-frequencies (over 40 kHz), the semiconductor layer allows for charge accumulation in the forward bias, light generating part of the AC cycle and charge compensation in the negative, quiescent part of the AC cycle. Such gated AC organic devices can achieve a non-output coupled luminance of 25,900 cd/m2 with power efficiencies that exceed both the insulator-based AC devices and OLEDs using the same emitters. This work clearly demonstrates that by realizing balanced management of charge, AC-driven organic light emitting devices may well be able to rival today’s OLEDs in performance. PMID:27063414

  11. Achieving High Performance in AC-Field Driven Organic Light Sources

    NASA Astrophysics Data System (ADS)

    Xu, Junwei; Carroll, David L.; Smith, Gregory M.; Dun, Chaochao; Cui, Yue

    2016-04-01

    Charge balance in organic light emitting structures is essential to simultaneously achieving high brightness and high efficiency. In DC-driven organic light emitting devices (OLEDs), this is relatively straight forward. However, in the newly emerging, capacitive, field-activated AC-driven organic devices, charge balance can be a challenge. In this work we introduce the concept of gating the compensation charge in AC-driven organic devices and demonstrate that this can result in exceptional increases in device performance. To do this we replace the insulator layer in a typical field-activated organic light emitting device with a nanostructured, wide band gap semiconductor layer. This layer acts as a gate between the emitter layer and the voltage contact. Time resolved device characterization shows that, at high-frequencies (over 40 kHz), the semiconductor layer allows for charge accumulation in the forward bias, light generating part of the AC cycle and charge compensation in the negative, quiescent part of the AC cycle. Such gated AC organic devices can achieve a non-output coupled luminance of 25,900 cd/m2 with power efficiencies that exceed both the insulator-based AC devices and OLEDs using the same emitters. This work clearly demonstrates that by realizing balanced management of charge, AC-driven organic light emitting devices may well be able to rival today’s OLEDs in performance.

  12. Challenges to achievement of metal sustainability in our high-tech society.

    PubMed

    Izatt, Reed M; Izatt, Steven R; Bruening, Ronald L; Izatt, Neil E; Moyer, Bruce A

    2014-04-21

    Achievement of sustainability in metal life cycles from mining of virgin ore to consumer and industrial devices to end-of-life products requires greatly increased recycling rates and improved processing of metals using conventional and green chemistry technologies. Electronic and other high-tech products containing precious, toxic, and specialty metals usually have short lifetimes and low recycling rates. Products containing these metals generally are incinerated, discarded as waste in landfills, or dismantled in informal recycling using crude and environmentally irresponsible procedures. Low recycling rates of metals coupled with increasing demand for high-tech products containing them necessitate increased mining with attendant environmental, health, energy, water, and carbon-footprint consequences. In this tutorial review, challenges to achieving metal sustainability, including projected use of urban mining, in present high-tech society are presented; health, environmental, and economic incentives for various government, industry, and public stakeholders to improve metal sustainability are discussed; a case for technical improvements, including use of molecular recognition, in selective metal separation technology, especially for metal recovery from dilute feed stocks is given; and global consequences of continuing on the present path are examined.

  13. Investigation of a nanofabrication process to achieve high aspect-ratio nanostructures on a quartz substrate.

    PubMed

    Mohamed, K; Alkaisi, M M

    2013-01-11

    This work investigates the development of a nanofabrication process to achieve high aspect-ratio nanostructures on quartz substrates using electron beam lithography (EBL) patterning and fluorinated plasma etching processes. An imaging layer of a poly(methyl methacrylate) bi-layer resist was spun coated on quartz substrate and exposed by an e-beam with the designed patterns of sub-100 nm feature sizes using a Raith-150 EBL patterning tool. Additive pattern transfer was employed by depositing a 40 nm thick Nichrome layer on the resist pattern using a metal evaporator which was later lifted off by soaking in acetone. Nichrome was employed as an etch mask and an Oxford Plasmalab 80Plus reactive ion etcher was used for the etching process. The etching process was carried out in a gas mixture of CHF(3)/Ar with a flow rate ratio of 50/30 sccm, pressure of 20 mTorr, radiofrequency power of 200 W and at room temperature. These etching process parameters were found to achieve a 10 nm min(-1) etch rate and tall vertical side walls profile. An aspect-ratio of 10:1 was achieved on 60 nm feature size structures.

  14. Investigation of a nanofabrication process to achieve high aspect-ratio nanostructures on a quartz substrate

    NASA Astrophysics Data System (ADS)

    Mohamed, K.; Alkaisi, M. M.

    2013-01-01

    This work investigates the development of a nanofabrication process to achieve high aspect-ratio nanostructures on quartz substrates using electron beam lithography (EBL) patterning and fluorinated plasma etching processes. An imaging layer of a poly(methyl methacrylate) bi-layer resist was spun coated on quartz substrate and exposed by an e-beam with the designed patterns of sub-100 nm feature sizes using a Raith-150 EBL patterning tool. Additive pattern transfer was employed by depositing a 40 nm thick Nichrome layer on the resist pattern using a metal evaporator which was later lifted off by soaking in acetone. Nichrome was employed as an etch mask and an Oxford Plasmalab 80Plus reactive ion etcher was used for the etching process. The etching process was carried out in a gas mixture of CHF3/Ar with a flow rate ratio of 50/30 sccm, pressure of 20 mTorr, radiofrequency power of 200 W and at room temperature. These etching process parameters were found to achieve a 10 nm min-1 etch rate and tall vertical side walls profile. An aspect-ratio of 10:1 was achieved on 60 nm feature size structures.

  15. Subpixel shift with Fourier transform to achieve efficient and high-quality image interpolation

    NASA Astrophysics Data System (ADS)

    Chen, Qin-Sheng; Weinhous, Martin S.

    1999-05-01

    A new approach to image interpolation is proposed. Different from the conventional scheme, the interpolation of a digital image is achieved with a sub-unity coordinate shift technique. In the approach, the original image is first shifted by sub-unity distances matching the locations where the image values need to be restored. The original and the shifted images are then interspersed together, yielding an interpolated image. High quality sub-unity image shift which is crucial to the approach is accomplished by implementing the shift theorem of Fourier transformation. It is well known that under the Nyquist sampling criterion, the most accurate image interpolation can be achieved with the interpolating function (sinc function). A major drawback is its computation efficiency. The present approach can achieve an interpolation quality as good as that with the sinc function since the sub-unity shift in Fourier domain is equivalent to shifting the sinc function in spatial domain, while the efficiency, thanks to the fast Fourier transform, is very much improved. In comparison to the conventional interpolation techniques such as linear or cubic B-spline interpolation, the interpolation accuracy is significantly enhanced. In order to compensate for the under-sampling effects in the interpolation of 3D medical images owing to a larger inter-slice distance, proper window functions were recommended. The application of the approach to 2- and 3-D CT and MRI images produced satisfactory interpolation results.

  16. Cognitive abilities and motivational processes in high school students' science achievement and engagement

    NASA Astrophysics Data System (ADS)

    Lau, Shun

    The dissertation presents two analytic approaches, a variable-centered and person-centered approach, to investigating holistic patterns of the cognitive, motivational, and affective correlates of science achievement and engagement in a sample of 491 10th and 11th grade high-school students. Building on Snow's (1989) idea of two pathways to achievement outcomes, Study 1 adopted a variable-centered approach to examining how cognitive and motivational factors associated with the performance and commitment pathways, respectively, contributed to the prediction of achievement outcomes in science. Results of hierarchical regression analyses showed that (a) students' cognitive abilities were the strongest predictors of their performance in science as measured by standardized test scores; (b) motivational processes enhanced the predictive validity for science test scores and grades beyond the variance accounted for by ability and demography; (c) motivational processes were the strongest predictors of students' commitment to science in the form of situational engagement and anticipated choices of science-related college majors and careers; and (d) competence beliefs served as a point of contact between the performance and commitment pathways. These results are consistent with Snow's (1989) conjecture that both performance and commitment pathway-related factors are necessary for understanding the full range of person-level inputs to achievement outcomes. Study 2 adopted a person-centered approach to examining holistic organizations of psychological factors within individuals and their relations to science achievement and engagement. Four types of students characterized by unique configurations of cognitive, motivational, and affective attributes were identified in both the male and female subsamples using inverse factor analysis. Type membership was found to distinguish students in various indicators of science achievement and engagement. Two of the four types were also found

  17. A new high school science program and its effect on student achievement in mathematics and science

    NASA Astrophysics Data System (ADS)

    Goodman, Robert

    Student achievement in mathematics and science is a high educational priority worldwide. The American educational system is not meeting its objectives for these subjects: our students are performing below international standards. The problem is endemic, leading to the conclusion that it is structural. During the last seven years, I have led the creation and implementation of a program whose aim is to address this problem. The structure of this program stresses horizontal and vertical curriculum articulations in order to increase curriculum efficiency and meaningfulness to students. My first aim, in conducting this study, was to determine the program's effectiveness. Since this was a long term program created in a real world environment it would be difficult to use experimental or quasi-experimental analysis. However, I was able to develop a plausible argument for the effectiveness of the program by using two measures to create a baseline for student aptitude and three measures to determine student achievement. Together these showed that the school's students, while typical of those in New Jersey, achieved very positive results in mathematic and science. The likelihood that the new program was responsible for this was enhanced by the fact that the verbal and mathematical aptitudes of the students were comparable, but their achievement in areas outside mathematic and science were not exceptional. My second aim was to provide documentation so that the program could be replicated at other schools. This included the scope and sequence of the mathematics and science courses; the curricula of the physics courses; an explanation the pedagogical approach used in the physics courses, and sample chapters of a textbook being written to support the first year physic course. Whiles those documents supply a snapshot of the current state of the program; they are probably insufficient to replicate it. This would also require an understanding of the program's rationale. Towards this

  18. Mathematical and numerical models to achieve high speed with special-purpose parallel processors

    SciTech Connect

    Cheng, H.S.; Wulff, W.; Mallen, A.N.

    1986-07-01

    One simulation facility that has been developed is the BNL Plant Analyzer, currently set up for BWR plant simulations at up to seven times faster than real-time process speeds. The principal hardware components of the BNL Plant Analyzer are two units of special-purpose parallel processors, the AD10 of Applied Dynamics International and a PDP-11/34 host computer. The AD10 is specifically designed for time-critical system simulations, utilizing the modern parallel processing technology with pipeline architecture. The simulator employs advanced modeling techniques and efficient integration techniques in conjunction with the parallel processors to achieve high speed performance.

  19. High School Principal Instructional Leadership Behavior in High and Low Need and High and Low Achievement Schools

    ERIC Educational Resources Information Center

    Fulton, Theodore T.

    2009-01-01

    The purpose of this study was to investigate teacher perceptions of the ten specific principal instructional leadership behaviors of Hallinger's Principal Instructional Management Rating Scale as they relate to school need, school achievement, years of experience as a teacher, and years working with the current principal. This quantitative…

  20. Number Sense-Based Strategies Used by High-Achieving Sixth Grade Students Who Experienced Reform Textbooks

    ERIC Educational Resources Information Center

    Alsawaie, Othman N.

    2012-01-01

    The purpose of this study was to explore strategies used by high-achieving 6th grade students in the United Arab Emirates (UAE) to solve basic arithmetic problems involving number sense. The sample for the study consisted of 15 high-achieving boys and 15 high-achieving girls in grade 6 from 2 schools in the Emirate of Abu Dhabi, UAE. Data for the…

  1. Achieving high mass-throughput of therapeutic proteins through parvovirus retentive filters.

    PubMed

    Bolton, Glen R; Basha, Jonida; Lacasse, Daniel P

    2010-01-01

    Parvovirus retentive filters that assure removal of viruses and virus-like particles during the production of therapeutic proteins significantly contribute to total manufacturing costs. Operational approaches that can increase throughput and reduce filtration area would result in a significant cost savings. A combination of methods was used to achieve high throughputs of an antibody or therapeutic protein solution through three parvovirus retentive filters. These methods included evaluation of diatomaceous earth or size-based prefilters, the addition of additives, and the optimization of protein concentration, temperature, buffer composition, and solution pH. An optimum temperature of 35°C was found for maximizing throughput through the Virosart CPV and Viresolve Pro filters. Mass-throughput values of 7.3, 26.4, and 76.2 kg/m(2) were achieved through the Asahi Planova 20N, Virosart CPV, and Viresolve Pro filters, respectively, in 4 h of processing. Mass-throughput values of 73, 137, and 192 kg/m(2) were achieved through a Millipore Viresolve Pro filter in 4.0, 8.8, and 22.1 h of processing, respectively, during a single experiment. However, large-scale parvovirus filtration operations are typically controlled to limit volumetric throughput to below the level achieved during small-scale virus spiking experiments. The virus spike may cause significant filter plugging, limiting throughput. Therefore newer parvovirus filter spiking strategies should be adopted that may lead to more representative viral clearance data and higher utilization of large-scale filter capacity.

  2. The Combined Effect of Teacher Effectiveness Characteristics on Value-Added Student Achievement in Junior High School Mathematics

    ERIC Educational Resources Information Center

    Wadleigh, Linda L.

    2013-01-01

    Student academic achievement in junior high mathematics is an ongoing mission for educational leaders. To achieve that undertaking, teacher effectiveness plays an important role. The purpose of this study was to examine the combined effects of teacher effectiveness on student achievement. The study was conducted in a suburban school district in…

  3. Achieving High Contrast for Exoplanet Imaging with a Kalman Filter and Stroke Minimization

    NASA Astrophysics Data System (ADS)

    Eldorado Riggs, A. J.; Groff, T. D.; Kasdin, N. J.; Carlotti, A.; Vanderbei, R. J.

    2014-01-01

    High contrast imaging requires focal plane wavefront control and estimation to correct aberrations in an optical system; non-common path errors prevent the use of conventional estimation with a separate wavefront sensor. The High Contrast Imaging Laboratory (HCIL) at Princeton has led the development of several techniques for focal plane wavefront control and estimation. In recent years, we developed a Kalman filter for optimal wavefront estimation. Our Kalman filter algorithm is an improvement upon DM Diversity, which requires at least two images pairs each iteration and does not utilize any prior knowledge of the system. The Kalman filter is a recursive estimator, meaning that it uses the data from prior estimates along with as few as one new image pairs per iteration to update the electric field estimate. Stroke minimization has proven to be a feasible controller for achieving high contrast. While similar to a variation of Electric Field Conjugation (EFC), stroke minimization achieves the same contrast with less stroke on the DMs. We recently utilized these algorithms to achieve high contrast for the first time in our experiment at the High Contrast Imaging Testbed (HCIT) at the Jet Propulsion Laboratory (JPL). Our HCIT experiment was also the first demonstration of symmetric dark hole correction in the image plane using two DMs--this is a major milestone for future space missions. Our ongoing work includes upgrading our optimal estimator to include an estimate of the incoherent light in the system, which allows for simultaneous estimation of the light from a planet along with starlight. The two-DM experiment at the HCIT utilized a shaped pupil coronagraph. Those tests utilized ripple style, free-standing masks etched out of silicon, but our current work is in designing 2-D optimized reflective shaped pupils. In particular, we have created several designs for the AFTA telescope, whose pupil presents major hurdles because of its atypical pupil obstructions. Our

  4. High Titer and Yields Achieved with Novel, Low-Severity Pretreatment Strategy

    SciTech Connect

    2016-03-01

    NREL researchers obtained high concentration sugar syrups in enzymatic hydrolysis that are fermentable to ethanol and other advanced biofuels and intermediate products at high yields. The novel DMR process is simpler and bypasses all severe pretreatment methods, thus reducing the environmental impact. The results are unprecedented. Researchers achieved a high concentration of sugars (230g/L of monomeric sugar and 270 g/L total sugar) and this low toxicity, highly fermentable syrup yielded 86 g/L ethanol (> 90 percent conversion). In addition, the lignin streams from this process can readily be converted to jet or renewable diesel blendstocks through a hydrodeoxygenation step. The NREL-developed, low severity DMR process may potentially replace higher severity chemical pretreatments and associated expensive reactors constructed of exotic alloys with a simpler process, using commercial-scale equipment commonly associated with the pulp and paper industry, to produce high concentration, low toxicity sugar streams and highly reactive lignin streams from non-food renewable biomass for biological and catalytic upgrading to advanced biofuels and chemicals. The simpler DMR process with black liquor recycling could reduce environmental and life-cycle impacts, and repurpose shuttered pulp and paper mills to help revitalize rural economies.

  5. Phase II Study of Vinorelbine and Estramustine in Combination With Conformational Radiotherapy for Patients With High-Risk Prostate Cancer

    SciTech Connect

    Carles, Joan; Nogue, Miguel; Sole, Josep M.; Foro, Palmira; Domenech, Montserrat; Suarez, Marta; Gallardo, Enrique; Garcia, Dario; Ferrer, Ferran; Gelabert-Mas, Antoni; Gayo, Javier; Fabregat, Xavier

    2010-03-15

    Purpose: To evaluate the efficacy and safety profile of vinorelbine and estramustine in combination with three-dimensional conformational radiotherapy (3D-CRT) in patients with localized high-risk prostate cancer. Methods and Materials: Fifty patients received estramustine, 600 mg/m{sup 2} daily, and vinorelbine, 25 mg/m{sup 2}, on days 1 and 8 of a 21-day cycle for three cycles in combination with 8 weeks of 3D-CRT (total dose of 70.2 gray [Gy] at 1.8-Gy fractions or 70 Gy at 2.0-Gy fractions). Additionally, patients received luteinizing hormone-releasing hormone analogs for 3 years. Results: All patients were evaluated for response and toxicity. Progression-free survival at 5 years was 72% (95% confidence interval [CI]: 52-86). All patients who relapsed had only biochemical relapse. The most frequent severe toxicities were cystitis (16% of patients), leucopenia (10% of patients), diarrhea (10% of patients), neutropenia (8% of patients), and proctitis (8% of patients). Six patients (12%) did not complete study treatment due to the patient's decision (n = 1) and to adverse events such as hepatotoxicity, proctitis, paralytic ileus, and acute myocardial infarction. Conclusions: Vinorelbine and estramustine in combination with 3D-CRT is a safe and effective regimen for patients with localized high-risk prostate cancer. A randomized trial is needed to determine whether the results of this regimen are an improvement over the results obtained with radiotherapy and androgen ablation.

  6. Conformational study of the binding of a high mobility group protein with chromatin

    SciTech Connect

    Sasi, R.; Huvoes, P.E.; Fasman, G.D.

    1982-10-10

    The nature of the binding of a high mobility group protein (HMG 17) to native and H1-H5-depleted chicken erythrocyte chromatin was studied, as a function of ionic strength, using circular dichroism and thermal denaturation techniques. The circular dichroism properties of the HMG 17-reconstituted whole chromatin and H1-H5-depleted chromatin structure occurred upon HMG 17 binding at low ionic strength. Thermal denaturation profiles confirmed this change in the structure of chromatin induced by HMG 17. Thermal denaturation profiles were resolved into three-component transitions. These results indicate that the binding sites of HMG 17 are situated in the linker regions immediately adjacent to the core. The nature of the interaction of HMG 17 at higher ionic strength with whole chromatin and H1-H5-depleted chromatin was found to be different. These observations suggest that HMG 17 does not loosen chromatin structure but produces an overall stabilization and condensation of structure. The implications of these results to the currently accepted models of transcriptionally active chromatin are discussed.

  7. The Pentagon-S process: A systematic approach for achieving high confidence in high-consequence products

    SciTech Connect

    D`Antonio, P.E.; Covan, J.M.; Ekman, M.E.

    1997-10-01

    Sandia National Laboratories has developed a systematic approach for achieving high confidence in major products requiring high reliability for use in high-consequence applications. A high-consequence application is one in which product failure could result in significant loss of life, damage to major systems or to the environment, financial loss, or political repercussions. The application of this process has proven to be of significant benefit in the early identification, verification, and correction of potential product design and manufacturing process failure modes. Early identification and correction of these failures modes and the corresponding controls placed on safety-critical features, ensures product adherence to safety-critical design requirements, and enhances product quality, reliability, and the cost effectiveness of delivered products. Safety-critical features include design features such as materials and dimensions, as well as manufacturing features such as assembly processes, inspections, and testing.

  8. What makes a good program? A case study of a school admitting high academic achievers.

    PubMed

    Lam, Ching Man

    2008-10-10

    This paper reports the results of a qualitative study that explored the administration and implementation of the Tier 1 Program (Secondary 1 Curriculum) of the Project P.A.T.H.S. The case study method was used to explore perceptions of the teachers and the project coordinator of program effectiveness, and to identify various factors for program success. A school admitting high academic achievers was selected, and site visits, as well as individual and focus group interviews, were conducted with the program coordinator, social worker, and course teachers. The results suggested that clear vision and program goals, high quality of curriculum, helpful leadership, positive teacher attitude, and strong administrative support are factors for program success. Analyzing the data enables the researchers to understand the characteristics of a successful program as well as the interplay among factors for producing success.

  9. Improving production of 11C to achieve high specific labelled radiopharmaceuticals

    NASA Astrophysics Data System (ADS)

    Savio, E.; García, O.; Trindade, V.; Buccino, P.; Giglio, J.; Balter, H.; Engler, H.

    2012-12-01

    Molecular imaging is usually based on the recognition by the radiopharmaceuticals of specific sites which are present in limited number or density in the cells or biological tissues. Thus is of high importance to label the radiopharmaceuticals with high specific activity to be able to achieve a high target to non target ratio. The presence of carbon dioxide (CO2) from the air containing 98,88% of 12C and 1,12% 13C compete with 11CO2 produced at the cyclotron. In order to minimize the presence of these isotopes along the process of irradiation, transferring and synthesis of radiopharmaceuticals labelled with 11C, we applied this method: previous to the irradiation the target was 3-4 times flushed with He (5.7) as a cold cleaning, followed by a similar conditioning of the line, from the target up to the module, and finally a hot cleaning in order to desorb 12CO2 and 13CO2, this was performed by irradiation during 1 min at 5 uA (3 times). In addition, with the aim of improving quality of gases in the target and in the modules, water traps (Agilent) were incorporated in the inlet lines of the target and modules. Target conditioning process (cold and hot flushings) as well as line cleaning, allowing the desorption of unlabelled CO2, together with the increasing of gas purity in the irradiation and in the synthesis, were critical parameters that enable to achieve 11C-radiopharamaceuticals with high specific activity, mainly in the case of 11C-PIB.

  10. Near-IR laser generation of a high-energy conformer of L-alanine and the mechanism of its decay in a low-temperature nitrogen matrix.

    PubMed

    Nunes, Cláudio M; Lapinski, Leszek; Fausto, Rui; Reva, Igor

    2013-03-28

    Monomers of L-alanine (ALA) were isolated in cryogenic nitrogen matrices at 14 K. Two conformers were identified for the compound trapped from the gas-phase into the solid nitrogen environment. The potential energy surface (PES) of ALA was theoretically calculated at the MP2 and QCISD levels. Twelve minima were located on this PES. Seven low-energy conformers fall within the 0-10 kJ mol(-1) range and should be appreciably populated in the equilibrium gas phase prior to deposition. Observation of only two forms in the matrices is explained in terms of calculated barriers to conformational rearrangements. All conformers with the O=C-O-H moiety in the cis orientation are separated by low barriers and collapse to the most stable form I during deposition of the matrix onto the low-temperature substrate. The second observed form II has the O=C-O-H group in the trans orientation. The remaining trans forms have very high relative energies (between 24 and 30 kJ mol(-1)) and are not populated. The high-energy trans form VI, that differs from I only by rotation of the OH group, was found to be separated from other conformers by barriers that are high enough to open a perspective for its stabilization in a matrix. The form VI was photoproduced in situ by narrow-band near-infrared irradiation of the samples at 6935-6910 cm(-1), where the first overtone of the OH stretching vibration in form I appears. The photogenerated form VI decays in N2 matrices back to conformer I with a characteristic decay time of ∼15 min. The mechanism of the VI → I relaxation is rationalized in terms of the proton tunneling.

  11. Conformational changes at the highly reactive cystein and lysine regions of skeletal muscle myosin induced by formation of transition state analogues.

    PubMed

    Maruta, S; Homma, K; Ohki, T

    1998-09-01

    Myosin forms stable ternary complexes with Mg2+-ADP and phosphate analogues of aluminum fluoride (AlF4-), beryllium fluoride (BeFn), and scandium fluoride (ScFn). These complexes are distinct from each other and may mimic different transient states in the ATPase cycle [Maruta et al. (1993) J. Biol. Chem. 268, 7093-7100]. Regions of skeletal muscle myosin containing the highly reactive residues Cys 707 (SH1), Cys 697 (SH2), and lysine 83 (RLR) dramatically alter their local conformation when myosin hydrolyzes ATP, and these changes may reflect formation of a series of transient intermediates during ATP hydrolysis. We used the fluorescent probes 4-fluoro-7-sulfamoylbezofurazan, 2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid, and trinitrobenzene-sulfonate, which bind to SH1, SH2, and RLR, respectively, to examine differences in local conformations within myosin.ADP.phosphate analogue (BeFn, Vi, AlF4-, and ScFn) complexes. It was observed that the ternary complexes had SH1 conformations similar to those seen on S-1 in the presence of ATP. In contrast, local conformations in the SH2 and RLR regions of S-1.ADP.BeFn were different from those in corresponding regions of S-1.ADP.AlF4- or ScFn. These results suggest that SH1 and SH2 move distinctly during ATP hydrolysis and that the local conformations of the SH2 and RLR regions more sensitively reflect different transient states.

  12. Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions.

    PubMed

    Stadhouders, Ralph; Kolovos, Petros; Brouwer, Rutger; Zuin, Jessica; van den Heuvel, Anita; Kockx, Christel; Palstra, Robert-Jan; Wendt, Kerstin S; Grosveld, Frank; van Ijcken, Wilfred; Soler, Eric

    2013-03-01

    Chromosome conformation capture (3C) technology is a powerful and increasingly popular tool for analyzing the spatial organization of genomes. Several 3C variants have been developed (e.g., 4C, 5C, ChIA-PET, Hi-C), allowing large-scale mapping of long-range genomic interactions. Here we describe multiplexed 3C sequencing (3C-seq), a 4C variant coupled to next-generation sequencing, allowing genome-scale detection of long-range interactions with candidate regions. Compared with several other available techniques, 3C-seq offers a superior resolution (typically single restriction fragment resolution; approximately 1-8 kb on average) and can be applied in a semi-high-throughput fashion. It allows the assessment of long-range interactions of up to 192 genes or regions of interest in parallel by multiplexing library sequencing. This renders multiplexed 3C-seq an inexpensive, quick (total hands-on time of 2 weeks) and efficient method that is ideal for the in-depth analysis of complex genetic loci. The preparation of multiplexed 3C-seq libraries can be performed by any investigator with basic skills in molecular biology techniques. Data analysis requires basic expertise in bioinformatics and in Linux and Python environments. The protocol describes all materials, critical steps and bioinformatics tools required for successful application of 3C-seq technology.

  13. Fractal Dimensions of Self-Avoiding Walks and Ising High-Temperature Graphs in 3D Conformal Bootstrap

    NASA Astrophysics Data System (ADS)

    Shimada, Hirohiko; Hikami, Shinobu

    2016-12-01

    The fractal dimensions of polymer chains and high-temperature graphs in the Ising model both in three dimension are determined using the conformal bootstrap applied for the continuation of the O( N) models from N=1 (Ising model) to N=0 (polymer). Even for non-integer N, the O( N) sum rule allows one to study the unitarity bound formally defined from the positivity, which may be violated in a non-unitary CFT. This unitarity bound of the scaling dimension for the O( N)-symmetric-tensor develops a kink as a function of the fundamental field as in the case of the energy operator dimension in the Z_2 (Ising) sum rule. Although this kink structure becomes less pronounced as N tends to zero, we found instead an emerging asymmetric minimum in the current central charge C_J. Despite the non-unitarity of the O( N) model at non-integer N, we find the C_J-kink along the unitarity bound lies very close to the location of the infrared (IR) O( N) CFT estimated by other methods. It is pointed out that certain level degeneracies at the IR CFT should induce these singular shapes of the unitarity bounds. As an application to the quantum and classical spin systems, we also predict critical exponents associated with the N=1 supersymmetry, which could be relevant for locating the corresponding fixed point in the phase diagram.

  14. High school students' perceptions of EFL teacher control orientations and their English academic achievement.

    PubMed

    Kiany, Gholam Reza; Shayestefar, Parvaneh

    2011-09-01

    BACKGROUND. Theories distinguish between student-initiated and teacher-initiated regulation of students' learning activities, or between strong, shared, or loose teacher control during the completion of learning tasks. Empirical validations for such distinctions are scarce, however. AIM. The present study aimed at (a) investigating students' perceptions of control behaviours exhibited by their English teachers; and (b) exploring the contribution of different types of teacher control behaviours to students' cognitive outcomes (English Achievement). SAMPLE. The sample comprised 732 English as a Foreign Language (EFL) students studying in three major fields of high school (Mathematics, Natural Science, and Humanities). The participants (16-17 years of age) were selected from third-grade classes of 27 EFL teachers working in 25 high schools of 6 main different geographical regions in the Isfahan province, Iran. METHOD. To obtain a comprehensive picture of different control types exhibited by Iranian EFL teachers, the control subscales of the two existing questionnaires, i.e., the Questionnaire on Instructional Behaviours (QIB), adapted by Den Brok et al. (2004) and the Questionnaire on Lesson Activities (QLA) used by Den Brok (2001) were merged to form the Questionnaire of Teacher Control (QTC). The development of this Persian instrument involved several steps: translation and back translation by the researchers, one expert translator, and two EFL teachers; piloting; and a final administration of the questionnaire to the student sample. With respect to the second aim of the study, data regarding students' performances on the Standardized National English Achievement Tests were gathered from local educational offices and schools. RESULTS AND CONCLUSION. Statistical analyses supported acceptable reliability and validity of the instrument. A main factor structure with three types of teacher control (strong/high, shared/mid, and loose/low) was found to underlie students

  15. Not choosing nursing: work experience and career choice of high academic achieving school leavers.

    PubMed

    Neilson, Gavin R; McNally, James G

    2010-01-01

    Work experience has been a feature of the secondary school curriculum in the United Kingdom for a number of years. Usually requested by the pupil, it aims to provide opportunities for school pupils to enhance their knowledge and understanding of an occupation. The main benefits are claimed to be that it can help pupils develop an insight into the skills and attitudes required for an occupation and an awareness of career opportunities. However the quality and choice of placements are considered to be of great importance in this process and in influencing career choice [Department for Education and Skills (DfES), 2002a. Work Experience: A Guide for Employers. Department for Education and Skills, London]. As university departments of nursing experience a decline in the number of school pupils entering student nurse education programmes, and with the competition for school leavers becoming even greater, it is important to consider whether school pupils have access to appropriate work placements in nursing and what influence their experience has on pursuing nursing as a career choice. This paper is based on interview data from 20 high academic achieving fifth and sixth year school pupils in Scotland, paradigmatic cases from a larger survey sample (n=1062), who had considered nursing as a possible career choice within their career preference cluster, but then later disregarded nursing and decided to pursue medicine or another health care profession. This was partly reported by Neilson and Lauder [Neilson, G.R., Lauder, W., 2008. What do high academic achieving school pupils really think about a career in nursing: analysis of the narrative from paradigmatic case interviews. Nurse Education Today 28(6), 680-690] which examined what high academic achieving school pupils really thought about a career in nursing. However, the data was particularly striking in revealing the poor quality of nursing work experience for the pupils, and also their proposal that there was a need

  16. Tuning charge balance in PHOLEDs with ambipolar host materials to achieve high efficiency

    SciTech Connect

    Padmaperuma, Asanga B.; Koech, Phillip K.; Cosimbescu, Lelia; Polikarpov, Evgueni; Swensen, James S.; Chopra, Neetu; So, Franky; Sapochak, Linda S.; Gaspar, Daniel J.

    2009-08-27

    The efficiency and stability of blue organic light emitting devices (OLEDs) continue to be a primary roadblock to developing organic solid state white lighting. For OLEDs to meet the high power conversion efficiency goal, they will require both close to 100% internal quantum efficiency and low operating voltage in a white light emitting device.1 It is generally accepted that such high quantum efficiency, can only be achieved with the use of organometallic phosphor doped OLEDs. Blue OLEDs are particularly important for solid state lighting. The simplest (and therefore likely the lowest cost) method of generating white light is to down convert part of the emission from a blue light source with a system of external phosphors.2 A second method of generating white light requires the superposition of the light from red, green and blue OLEDs in the correct ratio. Either of these two methods (and indeed any method of generating white light with a high color rendering index) critically depends on a high efficiency blue light component.3 A simple OLED generally consists of a hole-injecting anode, a preferentially hole transporting organic layer (HTL), an emissive layer that contains the recombination zone and ideally transports both holes and electrons, a preferentially electron-transporting layer (ETL) and an electron-injecting cathode. Color in state-of-the-art OLEDs is generated by an organometallic phosphor incorporated by co-sublimation into the emissive layer (EML).4 New materials functioning as hosts, emitters, charge transporting, and charge blocking layers have been developed along with device architectures leading to electrophosphorescent based OLEDs with high quantum efficiencies near the theoretical limit. However, the layers added to the device architecture to enable high quantum efficiencies lead to higher operating voltages and correspondingly lower power efficiencies. Achievement of target luminance power efficiencies will require new strategies for lowering

  17. High and Low Reading Comprehension Achievers' Strategic Behaviors and Their Relation to Performance in a Reading Comprehension Situation

    ERIC Educational Resources Information Center

    Dermitzaki, Irini; Andreou, Georgia; Paraskeva, Violetta

    2008-01-01

    This study aimed at investigating the actual strategic behaviors of high and low achievers in reading comprehension and their relation with respective performance. The participants were 45 individually examined third graders, 20 high and 25 low reading comprehension achievers. Cognitive, metacognitive, and motivational aspects of the participants'…

  18. A Comparison of Strategic Development for Multiplication Problem Solving in Low-, Average-, and High-Achieving Students

    ERIC Educational Resources Information Center

    Zhang, Dake; Ding, Yi; Barrett, Dave E.; Xin, Yan Ping; Liu, Ru-de

    2014-01-01

    The present study investigated the differences of strategy use between low-, average-, and high-achieving students when solving different multiplication problems. Nineteen high-, 48 average-, and 17 low-achieving students participated in this study. All participants were asked to complete three different multiplication tests and to explain how…

  19. Is Early Ability Grouping Good for High-Achieving Students' Psychosocial Development? Effects of the Transition into Academically Selective Schools

    ERIC Educational Resources Information Center

    Becker, Michael; Neumann, Marko; Tetzner, Julia; Böse, Susanne; Knoppick, Henrike; Maaz, Kai; Baumert, Jürgen; Lehmann, Rainer

    2014-01-01

    The present study investigates school context effects on psychosocial characteristics (academic self-concept, peer relations, school satisfaction, and school anxiety) of high-achieving and gifted students. Students who did or did not make an early transition from elementary to secondary schools for high-achieving and gifted students in 5th grade…

  20. The Difference in the Academic Achievement of Hispanic High School Students Based on the Theme of the Small Learning Community

    ERIC Educational Resources Information Center

    Martinez, Beate M. Winter

    2010-01-01

    The purpose of this study is to describe the difference in the academic achievement of urban Hispanic high school students based on the small learning community theme. The study used a quantitative method of ex post facto research to examine how the academic achievement of Hispanic high school students differs across the themes of small…

  1. Trajectories of Chinese Students' Sense of School Belonging and Academic Achievement over the High School Transition Period

    ERIC Educational Resources Information Center

    Liu, Yangyang; Lu, Zuhong

    2011-01-01

    The present study identified the different patterns of Chinese students' academic achievement trajectories over the high school transition period and examined the relationships between students' sense of school belonging trajectories and the different patterns of academic achievement trajectories. In a sample of 567 Chinese high school students, a…

  2. Robust and Fragile Mathematical Identities: A Framework for Exploring Racialized Experiences and High Achievement among Black College Students

    ERIC Educational Resources Information Center

    McGee, Ebony O.

    2015-01-01

    I introduce the construct of fragile and robust identities for the purpose of exploring the experiences that influenced the mathematical and racial identities of high-achieving Black college students in mathematics and engineering. These students maintained high levels of academic achievement in these fields while enduring marginalization,…

  3. Theoretical Study of Monolayer and Double-Layer Waveguide Love Wave Sensors for Achieving High Sensitivity.

    PubMed

    Li, Shuangming; Wan, Ying; Fan, Chunhai; Su, Yan

    2017-03-22

    Love wave sensors have been widely used for sensing applications. In this work, we introduce the theoretical analysis of the monolayer and double-layer waveguide Love wave sensors. The velocity, particle displacement and energy distribution of Love waves were analyzed. Using the variations of the energy repartition, the sensitivity coefficients of Love wave sensors were calculated. To achieve a higher sensitivity coefficient, a thin gold layer was added as the second waveguide on top of the silicon dioxide (SiO₂) waveguide-based, 36 degree-rotated, Y-cut, X-propagating lithium tantalate (36° YX LiTaO₃) Love wave sensor. The Love wave velocity was significantly reduced by the added gold layer, and the flow of wave energy into the waveguide layer from the substrate was enhanced. By using the double-layer structure, almost a 72-fold enhancement in the sensitivity coefficient was achieved compared to the monolayer structure. Additionally, the thickness of the SiO₂ layer was also reduced with the application of the gold layer, resulting in easier device fabrication. This study allows for the possibility of designing and realizing robust Love wave sensors with high sensitivity and a low limit of detection.

  4. Theoretical Study of Monolayer and Double-Layer Waveguide Love Wave Sensors for Achieving High Sensitivity

    PubMed Central

    Li, Shuangming; Wan, Ying; Fan, Chunhai; Su, Yan

    2017-01-01

    Love wave sensors have been widely used for sensing applications. In this work, we introduce the theoretical analysis of the monolayer and double-layer waveguide Love wave sensors. The velocity, particle displacement and energy distribution of Love waves were analyzed. Using the variations of the energy repartition, the sensitivity coefficients of Love wave sensors were calculated. To achieve a higher sensitivity coefficient, a thin gold layer was added as the second waveguide on top of the silicon dioxide (SiO2) waveguide–based, 36 degree–rotated, Y-cut, X-propagating lithium tantalate (36° YX LiTaO3) Love wave sensor. The Love wave velocity was significantly reduced by the added gold layer, and the flow of wave energy into the waveguide layer from the substrate was enhanced. By using the double-layer structure, almost a 72-fold enhancement in the sensitivity coefficient was achieved compared to the monolayer structure. Additionally, the thickness of the SiO2 layer was also reduced with the application of the gold layer, resulting in easier device fabrication. This study allows for the possibility of designing and realizing robust Love wave sensors with high sensitivity and a low limit of detection. PMID:28327504

  5. Science literacy in high school students: A comparison of achievement in two curriculum approaches

    NASA Astrophysics Data System (ADS)

    McAlister, Diane C.

    2009-12-01

    Academic achievement as measured by the Florida Comprehensive Assessment Test (FCAT) in science for 367 students in two science curriculum options, integrated science and the traditional subject-specific courses, in one central Florida high school were compared. A multivariate analysis of covariance (MANCOVA) of science curriculum choice was analyzed for three variables, total FCAT score, earth science subscore, and scientific thinking subscore. Covariate of academic ability as defined by grade point average (GPA) and academic focus as defined by post secondary plans were considered for use. Analysis of statistically significant results was completed through analysis of covariance (ANCOVA). While statistically significant results were found in favor of the traditional curriculum group, additional statistical analysis of the curriculum groups for differences in socioeconomic status (SES), gender, and instructional level led to a logistic regression to explore the ability of these variables, GPA, and total FCAT score to predict curriculum group membership. GPA, level of instruction and FCAT score were found to be statistically significant predictors. Final conclusions to the study indicated a significant difference in scientific literacy for the two groups in favor of the traditional curriculum. However, logistic regression results indicated that due to significant differences in SES, gender, GPA, and level of instruction for the groups, the differences in academic achievement were probably due to factors other than curriculum design. Limitations of the study and suggestions for further research were presented.

  6. Achieving behavioral control with millisecond resolution in a high-level programming environment.

    PubMed

    Asaad, Wael F; Eskandar, Emad N

    2008-08-30

    The creation of psychophysical tasks for the behavioral neurosciences has generally relied upon low-level software running on a limited range of hardware. Despite the availability of software that allows the coding of behavioral tasks in high-level programming environments, many researchers are still reluctant to trust the temporal accuracy and resolution of programs running in such environments, especially when they run atop non-real-time operating systems. Thus, the creation of behavioral paradigms has been slowed by the intricacy of the coding required and their dissemination across labs has been hampered by the various types of hardware needed. However, we demonstrate here that, when proper measures are taken to handle the various sources of temporal error, accuracy can be achieved at the 1 ms time-scale that is relevant for the alignment of behavioral and neural events.

  7. A High-Temperature Order-Disorder Phase Transition Coupled With Conformational Change in the Hybrid Material [C6 H13 NH]2 ⋅ZnBr4.

    PubMed

    Khan, Tariq; Asghar, Muhammad Adnan; Sun, Zhihua; Zeb, Aurang; Li, Lina; Sijie, Liu; Zhao, Sangen; Ji, Chengmin; Luo, Junhua

    2016-10-20

    A new high-temperature, hybrid, phase-transition material, 1-methylpiperidinium tetrabromozincate (1), that shows a reversible transition at 345 K was synthesized. Differential scanning calorimetry and specific heat capacity measurements confirmed this reversible transformation with a large heat hysteresis of 25 K, which describes a typical first-order phase transition in 1. The dielectric constant exhibited a steplike anomaly and showed high and low dielectric states in the high- and room-temperature phases, respectively, and therefore, this hybrid might be considered as a potential switchable dielectric material. The variable-temperature powder X-ray diffraction patterns displayed remarkable shifts between the experimental patterns at the two different phases. Single-crystal X-ray diffraction analyses at various temperatures revealed that the origin of this transformation could be attributed to disordering of the bromine atoms in the anion and the nitrogen atom of the cation. The cation also assumed a conformational change, which was likely induced by the disordered nitrogen atom. The conformational onset of the transformation of the cation from a planar conformer into a relaxed chair also occurred upon decreasing the temperature below transition point; thus, the combined order-disorder and conformational change induced the structural transformation and the change in symmetry.

  8. Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms

    PubMed Central

    Arora, Karunesh; Beard, William A.; Wilson, Samuel H.

    2012-01-01

    In recent papers, there has been a lively exchange concerning theories for enzyme catalysis, especially the role of protein dynamics/pre-chemistry conformational changes in the catalytic cycle of enzymes. Of particular interest is the notion that substrate-induced conformational changes that assemble the polymerase active site prior to chemistry are required for DNA synthesis and impact fidelity (i.e., substrate specificity). High-resolution crystal structures of DNA polymerase β representing intermediates of substrate complexes prior to the chemical step are available. These structures indicate that conformational adjustments in both the protein and substrates must occur to achieve the requisite geometry of the reactive participants for catalysis. We discuss computational and kinetic methods to examine possible conformational change pathways that lead from the observed crystal structure intermediates to the final structures poised for chemistry. The results, as well as kinetic data from site-directed mutagenesis studies, are consistent with models requiring pre-chemistry conformational adjustments in order to achieve high fidelity DNA synthesis. Thus, substrate-induced conformational changes that assemble the polymerase active site prior to chemistry contribute to DNA synthesis even when they do not represent actual rate-determining steps for chemistry. PMID:23459563

  9. Strategies for achieving high-level expression of genes in Escherichia coli.

    PubMed Central

    Makrides, S C

    1996-01-01

    Progress in our understanding of several biological processes promises to broaden the usefulness of Escherichia coli as a tool for gene expression. There is an expanding choice of tightly regulated prokaryotic promoters suitable for achieving high-level gene expression. New host strains facilitate the formation of disulfide bonds in the reducing environment of the cytoplasm and offer higher protein yields by minimizing proteolytic degradation. Insights into the process of protein translocation across the bacterial membranes may eventually make it possible to achieve robust secretion of specific proteins into the culture medium. Studies involving molecular chaperones have shown that in specific cases, chaperones can be very effective for improved protein folding, solubility, and membrane transport. Negative results derived from such studies are also instructive in formulating different strategies. The remarkable increase in the availability of fusion partners offers a wide range of tools for improved protein folding, solubility, protection from proteases, yield, and secretion into the culture medium, as well as for detection and purification of recombinant proteins. Codon usage is known to present a potential impediment to high-level gene expression in E. coli. Although we still do not understand all the rules governing this phenomenon, it is apparent that "rare" codons, depending on their frequency and context, can have an adverse effect on protein levels. Usually, this problem can be alleviated by modification of the relevant codons or by coexpression of the cognate tRNA genes. Finally, the elucidation of specific determinants of protein degradation, a plethora of protease-deficient host strains, and methods to stabilize proteins afford new strategies to minimize proteolytic susceptibility of recombinant proteins in E. coli. PMID:8840785

  10. Identification of high affinity bioactive Salbutamol conformer directed against mutated (Thr164Ile) beta 2 adrenergic receptor.

    PubMed

    Bandaru, Srinivas; Tiwari, Geet; Akka, Jyothy; Marri, Vijaya Kumar; Alvala, Mallika; Gutlapalli, Venkata Ravi; Nayarisseri, Anuraj; Mundluru, Hema Prasad

    2015-01-01

    Salbutamol forms an important and widely administered β2 agonist prescribed in the symptomatic treatment of bronchial asthma. Unfortunately, a subset of patients show refractoriness to it owing to ADRB2 gene variant (rs 1800888). The variant substitutes Thr to Ile at the position 164 in the β2 adrenergic receptor leading to sub-optimal binding of agonists. The present study aims to associate the Salbutamol response with the variant and select the bioactive conformer of Sabutamol with optimal binding affinity against mutated receptor by in silico approaches. To assess bronchodilator response spirometry was performed before and 15 min after Salbutamol (200 mcg) inhalation. Responders to Salbutamol were categorized if percentage reversibility was greater than or equal to 12%, while those showing FEV₁ reversibility less than 12% were classified as non-responders. Among the 344 subjects screened, 238 were responders and 106 were non-responders. The frequency of mutant allele "T" was significantly higher in case of non-responders (p < 0.05). In silico process involved generation of Salbutamol conformer ensembles supported by systematic search algorithm. 4369 conformers were generated of which only 1882 were considered bioactive conformers (threshold RMSD≤1 in reference to normalized structure of salbutamol). All the bioactive conformers were evaluated for the binding affinity against (Thr164 Ile) receptor through MolDock aided docking algorithm. One of the bioactive conformer (P.E. = -57.0038, RMSD = 0.6) demonstrated 1.54 folds greater affinity than the normal Salbutamol in the mutated receptor. The conformer identified in the present study may be put to pharmacodynamic and pharmacokinetic studies in future ahead.

  11. The Effects of School Bonding on High School Seniors' Academic Achievement

    ERIC Educational Resources Information Center

    Bryan, Julia; Moore-Thomas, Cheryl; Gaenzle, Stacey; Kim, Jungnam; Lin, Chia-Huei; Na, Goeun

    2012-01-01

    The authors examine the effects of school bonding on academic achievement (measured by math achievement scores) in a sample of 12th graders from the Educational Longitudinal Study of 2002 (Ingels, Pratt, Rogers, Siegel, & Stutts, 2005). Components of school bonding have proximal and distal effects on academic achievement. Attachment to school and…

  12. Superintendent Leadership and Student Achievement in Suburban High Schools: A Sequential Explanatory Mixed Methods Analysis

    ERIC Educational Resources Information Center

    Kellner, Steven Reese

    2012-01-01

    This research study explored the critical nature of the connection between student achievement and superintendent leadership. A great deal of scholarship has addressed either student achievement or leadership and previous evidence has suggested the impact of both parental education and racioethnicity on student achievement, but few studies have…

  13. Achieving high performance polymer tandem solar cells via novel materials design

    NASA Astrophysics Data System (ADS)

    Dou, Letian

    Organic photovoltaic (OPV) devices show great promise in low-cost, flexible, lightweight, and large-area energy-generation applications. Nonetheless, most of the materials designed today always suffer from the inherent disadvantage of not having a broad absorption range, and relatively low mobility, which limit the utilization of the full solar spectrum. Tandem solar cells provide an effective way to harvest a broader spectrum of solar radiation by combining two or more solar cells with different absorption bands. However, for polymer solar cells, the performance of tandem devices lags behind single-layer solar cells mainly due to the lack of suitable low-bandgap polymers (near-IR absorbing polymers). In this dissertation, in order to achieve high performance, we focus on design and synthesis of novel low bandgap polymers specifically for tandem solar cells. In Chapter 3, I demonstrate highly efficient single junction and tandem polymer solar cells featuring a spectrally matched low-bandgap conjugated polymer (PBDTT-DPP: bandgap, ˜1.44 eV). The polymer has a backbone based on alternating benzodithiophene and diketopyrrolopyrrole units. A single-layer device based on the polymer provides a power conversion efficiency of ˜6%. When the polymer is applied to tandem solar cells, a power conversion efficiency of 8.62% is achieved, which was the highest certified efficiency for a polymer solar cell. To further improve this material system, in Chapter 4, I show that the reduction of the bandgap and the enhancement of the charge transport properties of the low bandgap polymer PBDTT-DPP can be accomplished simultaneously by substituting the sulfur atoms on the DPP unit with selenium atoms. The newly designed polymer PBDTT-SeDPP (Eg = 1.38 eV) shows excellent photovoltaic performance in single junction devices with PCEs over 7% and photo-response up to 900 nm. Tandem polymer solar cells based on PBDTT-SeDPP are also demonstrated with a 9.5% PCE, which are more than 10

  14. Influence of acid-induced conformational variability on protein separation in reversed phase high performance liquid chromatography.

    PubMed

    Bobály, Balázs; Tóth, Eszter; Drahos, László; Zsila, Ferenc; Visy, Júlia; Fekete, Jenő; Vékey, Károly

    2014-01-17

    Influence of acid concentration in the mobile phase on protein separation was studied in a wide concentration range using trifluoroacetic acid (TFA) and formic acid (FA). At low, 0.001-0.01 (v/v%) TFA concentration and appropriate solvent strength proteins elute before the column's dead time. This is explained by the proteins having a structured, but relatively extended conformation in the eluent; and are excluded from the pores of the stationary phase. Above ca. 0.01-0.05 (v/v%) TFA concentration proteins undergo further conformational change, leading to a compact, molten globule-like structure, likely stabilized by ion pairing. Proteins in this conformation enter the pores and are retained on the column. The results suggest a pore exclusion induced separation related to protein conformation. This effect is influenced by the pH and type of acid used, and is likely to involve ion-pair formation. The TFA concentration needed to result in protein folding (and therefore to observe retention on the column) depends on the protein; and therefore can be utilized to improve chromatographic performance. Conformation change was monitored by circular dichroism spectroscopy and mass spectrometry; and it was shown that not only TFA but FA can also induce molten globule formation.

  15. Achieving High-Energy-High-Power Density in a Flexible Quasi-Solid-State Sodium Ion Capacitor.

    PubMed

    Li, Hongsen; Peng, Lele; Zhu, Yue; Zhang, Xiaogang; Yu, Guihua

    2016-09-14

    Simultaneous integration of high-energy output with high-power delivery is a major challenge for electrochemical energy storage systems, limiting dual fine attributes on a device. We introduce a quasi-solid-state sodium ion capacitor (NIC) based on a battery type urchin-like Na2Ti3O7 anode and a capacitor type peanut shell derived carbon cathode, using a sodium ion conducting gel polymer as electrolyte, achieving high-energy-high-power characteristics in solid state. Energy densities can reach 111.2 Wh kg(-1) at power density of 800 W kg(-1), and 33.2 Wh kg(-1) at power density of 11200 W kg(-1), which are among the best reported state-of-the-art NICs. The designed device also exhibits long-term cycling stability over 3000 cycles with capacity retention ∼86%. Furthermore, we demonstrate the assembly of a highly flexible quasi-solid-state NIC and it shows no obvious capacity loss under different bending conditions.

  16. Non-Planar Structures of the High-Energy Rotational Conformers of 2-METHYLBUTA-1,3-DIENE (isoprene) and 2,3-DIMETHYLBUTA-1,3-DIENE

    NASA Astrophysics Data System (ADS)

    Panchenko, Yu. N.; Bock, Ch. W.; Larkin, J. D.; Abramenkov, A. V.; Kühnemann, F.

    2009-06-01

    Optimization of the geometrical parameters and determination of the force fields for rotamers of the title molecules were performed at the MP2(FC)/aug-cc-pVDZ//MP2(FC)/aug-cc-pVDZ computational level. The vibrational analyses of these conformers were carried out using scaled quantum-mechanical force field methodology. Recent experimental wavenumbers for these conformers and their deuteroisomers were incorporated into these analyses. The theoretical non-planar structures of the high-energy conformers of 2-methylbuta-1,3-diene (isoprene) and 2,3-dimethylbuta-1,3-diene were corroborated by good agreement between the experimental and theoretical wavenumbers of the molecules under investigation. The dihedral angles of the non-planar high-energy conformers for rotation around the =C-C= bond are as follows: 41.6^° for 2-methylbuta-1,3-diene (isoprene) and 47.0^° for 2,3-dimethylbuta-1,3-diene. Previous studies performed at the HF/6-31G level gave 41.0^° and 48.5^° for the first and second compounds, respectively. Yu. N. Panchenko, Ch. W. Bock, J. D. Larkin, A. V. Abramenkov, F. Kühnemann, Struct. Chem. 19, 421 (2008). Yu. N. Panchenko, Ch. W. Bock, J. D. Larkin, A. V. Abramenkov, Struct. Chem. 19, 793 (2008)

  17. New insulating materials and their use to achieve high operating stresses in electrostatic machines

    NASA Astrophysics Data System (ADS)

    Cooke, Chathan M.

    1986-02-01

    Compressed gas insulation has provided the main insulation for sustaining terminal voltages of electrostatic accelerators. Essentially coaxial geometry is used with mechanical support of the terminal achieved by long columns which also support the acceleration tubes. Because of the vacuum insulation in the acceleration tubes, the electric gradient along the columns is typically 10-20 kV/cm, whereas the radial gas gap can operate at stresses about ten times larger. Until now, the terminal support has always been located in the low stress axial direction along the column and not in the radial high stress region. This paper is concerned with support insulation to be used in the radial direction. Advantages of radial supports include: simpler, more compact column structures, higher total voltages, and support of discrete stress redistribution electrodes such as vivitron. Important factors to the design of radial support insulators include the insulation constraints imposed by the gas gap, mechanical contact to the solid insulator, and basic limits of gas-solid dielectric interfaces. The gas gap insulation strength is shown to be limited by surface microirregularities and this accounts for electrode area and pressure effects. Based on the gas gap requirements, a design strategy for the insulators is developed. Epoxy is employed as the dielectric to allow the use of cast-in metal inserts at the ends. The inserts provide mechanical contact, shielding of the triple junction, and redistribution of the interface electric stresses. By careful design, the electric stress on the interface is made lower than that in the plain coaxial electrode gap. Practical experience shows that voltage increases linearly with insulator length and that designs achieve more than 10 MV/m into the multimegavolt region.

  18. Evaluation of dialyzer jacket structure and hollow-fiber dialysis membranes to achieve high dialysis performance.

    PubMed

    Hirano, Ayaka; Yamamoto, Ken-ichiro; Matsuda, Masato; Ogawa, Takehito; Yakushiji, Taiji; Miyasaka, Takehiro; Sakai, Kiyotaka

    2011-02-01

    The objective of this study was to determine the optimum dialyzer jacket structure and hollow-fiber dialysis membrane, both of which are indispensable factors for achieving high dialysis performance, by clarifying the relationship between the dialysis performance and the flow of dialysate and blood in a hollow-fiber dialyzer. We evaluated the clearance, dialysate, and blood flow for four commercially available hollow-fiber dialyzers, namely, the APS-15S, APS-15SA, TS-1.6UL, and CX-1.6U. To evaluate dialysate and blood flow, we measured the residence-time distribution of dialysate and blood flow of these dialyzers by the pulse-response method. We also determined the clearances of urea, creatinine, vitamin B(12), and lysozyme to evaluate the dialysis performance of these dialyzers. While the baffle and taper structures allow effective supply of dialysate into the dialyzer jacket, the hollow-fiber shape, inner diameter, and packing density significantly influence the dialysate flow. In dialyzers with long taper-holding slits, the slit area is a key design parameter for achieving optimum dialysate flow. Similarly, the blood flow is significantly influenced by the structure of the inflowing and outflowing blood ports at the header of a dialyzer, and the shape and inner diameter of the hollow fibers. Hollow fibers with smaller inner diameters cause an increase in blood pressure, which causes blood to enter the hollow fibers more easily. The hollow-fiber shape hardly affects the blood flow. While improved dialysate and blood flow cause higher clearance of low molecular-weight substances, higher membrane area and pure-water permeability accelerate internal filtration, thereby causing an increase in the clearance of large molecular-weight substances.

  19. Polyaspartamide derivative nanoparticles with tunable surface charge achieve highly efficient cellular uptake and low cytotoxicity.

    PubMed

    Xu, Min; Zhao, Yuefang; Feng, Min

    2012-08-07

    Cationic nanocarrier mediated intracellular therapeutic agent delivery acts as a double-edged sword: the carriers promote cellular uptake, but interact nonspecifically and strongly with negatively charged endogenic proteins and cell membranes, which results in aggregates and high cytotoxicity. The present study was aimed at exploring zwitterionic polyaspartamide derivative nanoparticles for efficient intracellular delivery with low cytotoxicity. Poly(aspartic acid) partially grafted tetraethylenepentamine (PASP-pg-TEPA) with different isoelectric points (IEPs) was synthesized. The PASP-pg-TEPA formed zwitterionic nanoparticles with an irregular core and a well-defined shell structure in aqueous medium. Their particle size decreased from about 300 to 80 nm with an increase of the IEP from 7.5 to 9.1. The surface charge of the PASP-pg-TEPA nanoparticles could be tuned from positive to negative with a change of the pH of the medium. The nanoparticles with an IEP above 8.5 exhibited good stability under simulated physiological conditions. It was noted that the zwitterionic PASP-pg-TEPA nanoparticles displayed highly efficient cellular uptake in HeLa cells (approximately 99%) in serum-containing medium and did not adversely affect the cell viability at concentrations up to 1 mg/mL. Furthermore, thermodynamic analysis using isothermal titration calorimetry provided direct evidence that these zwitterionic nanoparticles had low binding affinities for serum protein. Therefore, the zwitterionic PASP-pg-TEPA nanoparticles could overcome limitations of cationic nanocarriers and achieve efficient intracellular delivery with low cytotoxicity.

  20. Autonomous Information Fading and Provision to Achieve High Response Time in Distributed Information Systems

    NASA Astrophysics Data System (ADS)

    Lu, Xiaodong; Arfaoui, Helene; Mori, Kinji

    In highly dynamic electronic commerce environment, the need for adaptability and rapid response time to information service systems has become increasingly important. In order to cope with the continuously changing conditions of service provision and utilization, Faded Information Field (FIF) has been proposed. FIF is a distributed information service system architecture, sustained by push/pull mobile agents to bring high-assurance of services through a recursive demand-oriented provision of the most popular information closer to the users to make a tradeoff between the cost of information service allocation and access. In this paper, based on the analysis of the relationship that exists among the users distribution, information provision and access time, we propose the technology for FIF design to resolve the competing requirements of users and providers to improve users' access time. In addition, to achieve dynamic load balancing with changing users preference, the autonomous information reallocation technology is proposed. We proved the effectiveness of the proposed technology through the simulation and comparison with the conventional system.

  1. The clinical potential of high energy, intensity and energy modulated electron beams optimized by simulated annealing for conformal radiation therapy

    NASA Astrophysics Data System (ADS)

    Salter, Bill Jean, Jr.

    Purpose. The advent of new, so called IVth Generation, external beam radiation therapy treatment machines (e.g. Scanditronix' MM50 Racetrack Microtron) has raised the question of how the capabilities of these new machines might be exploited to produce extremely conformal dose distributions. Such machines possess the ability to produce electron energies as high as 50 MeV and, due to their scanned beam delivery of electron treatments, to modulate intensity and even energy, within a broad field. Materials and methods. Two patients with 'challenging' tumor geometries were selected from the patient archives of the Cancer Therapy and Research Center (CTRC), in San Antonio Texas. The treatment scheme that was tested allowed for twelve, energy and intensity modulated beams, equi-spaced about the patient-only intensity was modulated for the photon treatment. The elementary beams, incident from any of the twelve allowed directions, were assumed parallel, and the elementary electron beams were modeled by elementary beam data. The optimal arrangement of elementary beam energies and/or intensities was optimized by Szu-Hartley Fast Simulated Annealing Optimization. Optimized treatment plans were determined for each patient using both the high energy, intensity and energy modulated electron (HIEME) modality, and the 6 MV photon modality. The 'quality' of rival plans were scored using three different, popular objective functions which included Root Mean Square (RMS), Maximize Dose Subject to Dose and Volume Limitations (MDVL - Morrill et. al.), and Probability of Uncomplicated Tumor Control (PUTC) methods. The scores of the two optimized treatments (i.e. HIEME and intensity modulated photons) were compared to the score of the conventional plan with which the patient was actually treated. Results. The first patient evaluated presented a deeply located target volume, partially surrounding the spinal cord. A healthy right kidney was immediately adjacent to the tumor volume, separated

  2. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins.

    PubMed

    Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean

    2005-06-21

    Discoidal forms of high density lipoproteins (HDL) are critical intermediates between lipid-poor apolipoprotein A-I (apo A-I), the major protein constituent of HDL, and the mature spherical forms that comprise the bulk of circulating particles. Thus, many studies have focused on understanding apoA-I structure in discs reconstituted in vitro. Recent theoretical and experimental work supports a "belt" model for apoA-I in which repeating amphipathic helical domains run parallel to the plane of the lipid disc. However, disc-associated apoA-I can adopt several tertiary arrangements that are consistent with a belt orientation. To distinguish among these, we cross-linked near-neighbor Lys groups in homogeneous 96 A discs containing exactly two molecules of apoA-I. After delipidation and tryptic digestion, mass spectrometry was used to identify 9 intermolecular and 11 intramolecular cross-links. The cross-linking pattern strongly suggests a "double-belt" molecular arrangement for apoA-I in which two apoA-I molecules wrap around the lipid bilayer disc forming two stacked rings in an antiparallel orientation with helix 5 of each apoA-I in juxtaposition (LL5/5 orientation). The data also suggests the presence of an additional double-belt orientation with a shifted helical registry (LL5/2 orientation). Furthermore, a 78 A particle with two molecules of apoA-I fit a similar double-belt motif with evidence for conformational changes in the N-terminus and the region near helix 5. A comparison of this work to a previous study is suggestive that a third molecule of apoA-I can form a hairpin in larger particles containing three molecules of apoA-I.

  3. Qualitative research study of high-achieving females' life experiences impacting success

    NASA Astrophysics Data System (ADS)

    Butcher, Ann Patrice

    2003-07-01

    This qualitative study investigated the life experiences of five academically gifted female students in math and science in reflection of their elementary learning prior to enrollment at a prestigious science and mathematics high school. The elite high school limits admission to the state of Illinois' top students. The purpose of this study is to unfold the story of five academically gifted females in attendance at the elite high school reflecting on their life experiences in elementary school that contributed to their current academic success. Twelve female students, who at the time of this study were currently in their senior year (12th grade) of high school, were solicited from the top academic groups who are regarded by their teachers as highly successful in class. Students were selected as part of the study based on academic status, survey completion and interest in study, Caucasian and Asian ethnicity, locale of elementary school with preference given to the variety of school demographics---urban, suburban, and rural---further defined the group to the core group of five. All female participants were personally interviewed and communicated via Internet with the researcher. Parents and teachers completing surveys as well met the methodological requirements of triangulation. An emergent theme of paternal influence came from the research. Implications supported in the research drawn from this study to increase achievement of academically gifted females include: (a) proper early identification of learner strengths plays a role; (b) learning with appropriate intellectual peers is more important than learning with their age group; (c) teachers are the greatest force for excellent instruction; (d) effective teaching strategies include cooperative learning, multi-sensory learning, problem-based learning, and hands-on science; (e) rigor in math is important; (f) gender and stereotypes need not be barriers; (g) outside interests and activities are important for self

  4. Optimal microelectromechanical systems (MEMS) device for achieving high pyroelectric response of AlN

    NASA Astrophysics Data System (ADS)

    Kebede, Bemnnet; Coutu, Ronald A.; Starman, LaVern

    2014-03-01

    This paper discusses research being conducted on aluminum nitride (AlN) as a pyroelectric material for use in detecting applications. AlN is being investigated because of its high pyroelectric coefficient, thermal stability, and high Curie temperature. In order to determine suitability of the pyroelectric properties of AlN for use as a detector, testing of several devices was conducted. These devices were fabricated using microelectromechanical systems (MEMS) fabrication processes; the devices were also designed to allow for voltage and current measurements. The deposited AlN films used were 150 nm - 300 nm in thickness. Thin-films were used to rapidly increase the temperature response after the thermal stimulus was applied to the pyroelectric material. This is important because the pyroelectric effect is directly proportional to the rate of temperature change. The design used was a face-electrode bridge that provides thermal isolation which minimizes heat loss to the substrate, thereby increasing operation frequency of the pyroelectric device. A thermal stimulus was applied to the pyroelectric material and the response was measured across the electrodes. A thermal imaging camera was used to monitor the changes in temperature. Throughout the testing process, the annealing temperatures, type of layers, and thicknesses were also varied. These changes resulted in improved MEMS designs, which were fabricated to obtain an optimal design configuration for achieving a high pyroelectric response. A pyroelectric voltage response of 38.9 mVp-p was measured without filtering, 12.45 mVp-p was measured in the infrared (IR) region using a Si filter, and 6.38 mVp-p was measured in the short wavelength IR region using a long pass filter. The results showed that AlN's pyroelectric properties can be used in detecting applications.

  5. Longitudinal Outcomes of Start Time Delay on Sleep, Behavior, and Achievement in High School

    PubMed Central

    Thacher, Pamela V.; Onyper, Serge V.

    2016-01-01

    Study Objectives: To establish whether sleep, health, mood, behavior, and academics improved after a 45-minute delay in high school start time, and whether changes persisted longitudinally. Methods: We collected data from school records and student self-report across a number of domains at baseline (May 2012) and at two follow-up time points (November 2012 and May 2013), at a public high school in upstate New York. Students enrolled during academic years (AY) 2011–2012 and 2012–2013 completed the Pittsburgh Sleep Quality Index; the DASS-21; the “Owl-Lark” Scale; the Daytime Sleepiness Index; and a brief self-report of health. Reports from school records regarding attendance, tardiness, disciplinary violations, and academic performance were collected for AY 2010–2011 through 2013–2014. Results: Students delayed but did not extend their sleep period; we found lasting improvements in tardiness and disciplinary violations after the start-time delay, but no changes to other variables. At the first follow-up, students reported 20 minutes longer sleep, driven by later rise times and stable bed times. At the second follow-up, students maintained later rise times but delayed bedtimes, returning total sleep to baseline levels. A delay in rise time, paralleling the delay in the start time that occurred, resulted in less tardiness and decreased disciplinary incidents, but larger improvements to sleep patterns may be necessary to affect health, attendance, sleepiness, and academic performance. Conclusions: Later start times improved tardiness and disciplinary issues at this school district. A delay in start time may be a necessary but not sufficient means to increase sleep time and may depend on preexisting individual differences. Commentary: A commentary on this article appears in this issue on page 267. Citation: Thacher PV, Onyper SV. Longitudinal outcomes of start time delay on sleep, behavior, and achievement in high school. SLEEP 2016;39(2):271–281. PMID

  6. Performance Assessment of High and Low Income Families through "Online RAW Achievement Battery Test" of Primary Grade Students

    ERIC Educational Resources Information Center

    Ahmed, Tamim; Hanif, Maria

    2016-01-01

    This study is intended to investigate student's achievement capability among two families i.e. Low and High income families and designed for primary level learners. A Reading, Arithmetic and Writing (RAW) Achievement test that was developed as a part of another research study (Tamim Ahmed Khan, 2015) was adopted for this study. Both English medium…

  7. Bright and Beautiful: High Achieving Girls, Ambivalent Femininities, and the Feminization of Success in the Primary School

    ERIC Educational Resources Information Center

    Renold, Emma; Allan, Alexandra

    2006-01-01

    This paper refocuses attention on and problematizes girls' experiences of school achievement and the construction of schoolgirl femininities. In particular, it centres on the relatively neglected experiences and identity work of high achieving primary school girls. Drawing upon ethnographic data (observations, interviews, and pupil diaries) from a…

  8. (Re)Defining the Narrative: High-Achieving Nontraditional Black Male Undergraduates at a Historically Black College and University

    ERIC Educational Resources Information Center

    Goings, Ramon B.

    2016-01-01

    Using Harper's anti-deficit achievement framework as a theoretical guide, the purpose of this phenomenological study was to investigate the academic and social experiences of four nontraditional, high-achieving, Black male undergraduates attending one historically Black university. Findings show that the participants were intrinsically motivated…

  9. The Relationship between Professional Learning Community Implementation and Academic Achievement and Graduation Rates in Georgia High Schools

    ERIC Educational Resources Information Center

    Hardinger, Regina Gail

    2013-01-01

    Many educational administrators in Georgia continue to struggle with low student academic achievement and low high school graduation rates. DuFour's professional learning community (PLC) theory suggests a positive relationship between levels of PLC implementation and academic achievement and between levels of PLC implementation and graduation…

  10. The Relationship between Professional Learning Communities, Personal Teacher Efficacy, and Student Achievement at the High School Level

    ERIC Educational Resources Information Center

    Brooks, Sherri L.

    2013-01-01

    The purpose of this correlational study was to determine if there was a relationship between professional learning community (PLC), personal teacher efficacy (PTE), and student achievement. The study examined teacher perception of PLC implementation and PET as it related to student achievement at the high school level on the Virginia End-of Course…

  11. American High School Students from Different Ethnic Backgrounds: The Role of Parents and the Classroom in Achievement Motivation

    ERIC Educational Resources Information Center

    Kim, Jung-In

    2015-01-01

    The purpose of this study was to investigate the relationships between ethnically diverse US high school students' (N = 331) perceptions of their parents' or classroom's motivating factors and their achievement motivation in their math class, connecting achievement goal orientation and self-determination theories. Two hypothesized path models were…

  12. Academic Achievement Trajectories of Homeless and Highly Mobile Students: Resilience in the Context of Chronic and Acute Risk

    ERIC Educational Resources Information Center

    Cutuli, J. J.; Desjardins, Christopher David; Herbers, Janette E.; Long, Jeffrey D.; Heistad, David; Chan, Chi-Keung; Hinz, Elizabeth; Masten, Ann S.

    2013-01-01

    Analyses examined academic achievement data across third through eighth grades ("N" = 26,474), comparing students identified as homeless or highly mobile (HHM) with other students in the federal free meal program (FM), reduced price meals (RM), or neither (General). Achievement was lower as a function of rising risk status (General…

  13. A Longitudinal Study of the Social Distribution of Mathematics Achievement for a Cohort of Public High School Students.

    ERIC Educational Resources Information Center

    Mandeville, Garrett K.; Kennedy, Eugene

    This paper reports the results of a study of changes in the social distribution of mathematics achievement for a cohort of public high school students. Using hierarchical linear modeling (HLM) the study sought to identify school characteristics which were significantly correlated with changes in achievement differences from grade 9 to grade 11…

  14. Differences in Self-Concept among Children with Mathematics Disabilities and Their Average and High Achieving Peers

    ERIC Educational Resources Information Center

    Zeleke, Seleshi

    2004-01-01

    Self-concept ratings of children with mathematics disabilities (MD), average mathematics achievement (AA), and high mathematics achievement (HA) who attended regular classes in grades 4 through 6 were compared. Twenty-four children in each group, who were selected from an original pool of 811 children, and who were matched one-to-one by grade,…

  15. A comparison of rural high school students in Germany with rural Tennessee high school students' mathematics and science achievement

    NASA Astrophysics Data System (ADS)

    Harding, R. Fredrick

    This descriptive study compared the science and mathematics aptitudes and achievement test scores for the final school year students in rural White County and Van Buren County, Tennessee with rural county students in Germany. In accordance with the previous research literature (Stevenson, 2002), German students outperformed U.S. students on The International Trends in Math and Science test (TIMSS). As reform in the U.S. education system has been underway, this study intended to compare German county student final school year performance with White County and Van Buren County (Grade 12) performance in science and mathematics. The entire populations of 176 White and Van Buren Counties senior high final school year students were compared with 120 school final year students from two rural German county high schools. The student responses to identical test and questionnaire items were compared using the t-test statistical analysis. In conclusion after t-test analyses, there was no significant difference (p>.05 level) in student attitudes on the 27 problem achievement and the 35 TIMSS questionnaire items between the sampled population of 120 German students compared with the population of 176 White and Van Buren students. Also, there was no statistically significant difference (p>.05 level) between the German, White, and Van Buren County rural science and math achievement in the TIMSS problem section of the final year test. Based on the research, recommendations to improve U.S. student scores to number one in the world include making changes in teaching methodology in mathematics and science; incorporating pamphlet lessons rather than heavily reliance on textbooks; focusing on problem solving; establishing an online clearinghouse for effective lessons; creating national standards in mathematics and science; matching students' course choices to job aspirations; tracking misbehaving students rather than mainstreaming them into the regular classroom; and designing

  16. New Powder Metallurgical Approach to Achieve High Fatigue Strength in Ti-6Al-4V Alloy

    NASA Astrophysics Data System (ADS)

    Cao, Fei; Ravi Chandran, K. S.; Kumar, Pankaj; Sun, Pei; Zak Fang, Z.; Koopman, Mark

    2016-05-01

    Recently, manufacturing of titanium by sintering and dehydrogenation of hydride powders has generated a great deal of interest. An overarching concern regarding powder metallurgy (PM) titanium is that critical mechanical properties, especially the high-cycle fatigue strength, are lower than those of wrought titanium alloys. It is demonstrated here that PM Ti-6Al-4V alloy with mechanical properties comparable (in fatigue strength) and exceeding (in tensile properties) those of wrought Ti-6Al-4V can be produced from titanium hydride powder, through the hydrogen sintering and phase transformation process. Tensile and fatigue behavior, as well as fatigue fracture mechanisms, have been investigated under three processing conditions. It is shown that a reduction in the size of extreme-sized pores by changing the hydride particle size distribution can lead to improved fatigue strength. Further densification by pneumatic isostatic forging leads to a fatigue strength of ~550 MPa, comparable to the best of PM Ti-6Al-4V alloys prepared by other methods and approaching the fatigue strengths of wrought Ti-6Al-4V alloys. The microstructural factors that limit fatigue strength in PM titanium have been investigated, and pathways to achieve greater fatigue strengths in PM Ti-6Al-4V alloys have been identified.

  17. The Stories Clinicians Tell: Achieving High Reliability and Improving Patient Safety

    PubMed Central

    Cohen, Daniel L; Stewart, Kevin O

    2016-01-01

    The patient safety movement has been deeply affected by the stories patients have shared that have identified numerous opportunities for improvements in safety. These stories have identified system and/or human inefficiencies or dysfunctions, possibly even failures, often resulting in patient harm. Although patients’ stories tell us much, less commonly heard are the stories of clinicians and how their personal observations regarding the environments they work in and the circumstances and pressures under which they work may degrade patient safety and lead to harm. If the health care industry is to function like a high-reliability industry, to improve its processes and achieve the outcomes that patients rightly deserve, then leaders and managers must seek and value input from those on the front lines—both clinicians and patients. Stories from clinicians provided in this article address themes that include incident identification, disclosure and transparency, just culture, the impact of clinical workload pressures, human factors liabilities, clinicians as secondary victims, the impact of disruptive and punitive behaviors, factors affecting professional morale, and personal failings. PMID:26580146

  18. Fair and Just Culture, Team Behavior, and Leadership Engagement: The Tools to Achieve High Reliability

    PubMed Central

    Frankel, Allan S; Leonard, Michael W; Denham, Charles R

    2006-01-01

    Background Disparate health care provider attitudes about autonomy, teamwork, and administrative operations have added to the complexity of health care delivery and are a central factor in medicine's unacceptably high rate of errors. Other industries have improved their reliability by applying innovative concepts to interpersonal relationships and administrative hierarchical structures (Chandler 1962). In the last 10 years the science of patient safety has become more sophisticated, with practical concepts identified and tested to improve the safety and reliability of care. Objective Three initiatives stand out as worthy regarding interpersonal relationships and the application of provider concerns to shape operational change: The development and implementation of Fair and Just Culture principles, the broad use of Teamwork Training and Communication, and tools like WalkRounds that promote the alignment of leadership and frontline provider perspectives through effective use of adverse event data and provider comments. Methods Fair and Just Culture, Teamwork Training, and WalkRounds are described, and implementation examples provided. The argument is made that they must be systematically and consistently implemented in an integrated fashion. Conclusions There are excellent examples of institutions applying Just Culture principles, Teamwork Training, and Leadership WalkRounds—but to date, they have not been comprehensively instituted in health care organizations in a cohesive and interdependent manner. To achieve reliability, organizations need to begin thinking about the relationship between these efforts and linking them conceptually. PMID:16898986

  19. Achieving high survival of tournament-caught black bass: past efforts and future needs and opportunities

    USGS Publications Warehouse

    Schramm, Harold; Gilliland, Gene

    2015-01-01

    Rapid growth of black bass (Micropterus spp.) tournaments in the 1960s and 1970s caused concern among fisheries managers and anglers about the impacts of tournament-caused mortality on bass populations. Tournament organizers voluntarily implemented live-release events in the early 1980s. As catch-and-release practices became more common, procedures to improve the survival of tournament-caught fish were developed and have evolved. The objectives of this paper are to review education and outreach efforts to improve survival of tournament-caught black bass, suggest research needs and opportunities to achieve greater survival, and show the relevance of high survival to contemporary black bass management. Since 1985, a succession of informational products describing those techniques have been developed and distributed to anglers. Although research has confirmed the effectiveness of the recommended procedures and documented that angler and tournament organizer behavior has changed and the survival of tournament-caught black bass has increased, the impacts of the outreach efforts on tournament practices have not been quantified. Continued efforts towards increasing angler awareness of proper handling techniques may benefit from better communication, endorsement by professional anglers, and the use of incentives by state agencies to encourage better fish care.

  20. Achieving high-precision pointing on ExoplanetSat: initial feasibility analysis

    NASA Astrophysics Data System (ADS)

    Pong, Christopher M.; Lim, Sungyung; Smith, Matthew W.; Miller, David W.; Villaseñor, Jesus S.; Seager, Sara

    2010-07-01

    ExoplanetSat is a proposed three-unit CubeSat designed to detect down to Earth-sized exoplanets in an orbit out to the habitable zone of Sun-like stars via the transit method. To achieve the required photometric precision to make these measurements, the target star must remain within the same fraction of a pixel, which is equivalent to controlling the pointing of the satellite to the arcsecond level. The satellite will use a two-stage control system: coarse control will be performed by a set of reaction wheels, desaturated by magnetic torque coils, and fine control will be performed by a piezoelectric translation stage. Since no satellite of this size has previously demonstrated this high level of pointing precision, a simulation has been developed to prove the feasibility of realizing such a system. The current baseline simulation has demonstrated the ability to hold the target star to within 0.05 pixels or 1.8 arcseconds (with an 85 mm lens and 15 μm pixels), in the presence of large reaction wheel disturbances as well as external environmental disturbances. This meets the current requirement of holding the target star to 0.14 pixels or 5.0 arcseconds. Other high-risk aspects of the design have been analyzed such as the effect of changing the guide star centroiding error, changing the CMOS sampling frequency, and reaction wheel selection on the slew performance of the satellite. While these results are promising as an initial feasibility analysis, further model improvements and hardware-in-the-loop tests are currently underway.

  1. Motivational Factors Contributing to Turkish High School Students' Achievement in Gases and Chemical Reactions

    ERIC Educational Resources Information Center

    Kadioglu, Cansel; Uzuntiryaki, Esen

    2008-01-01

    This study aimed to investigate the contribution of motivational factors to 10th grade students' achievement in gases and chemical reactions in chemistry. Three hundred fifty nine 10th grade students participated in the study. The Gases and Chemical Reactions Achievement Test and the Motivated Strategies for Learning Questionnaire were…

  2. Job Choice As a Function of SES and Achievement Scores For High School Students.

    ERIC Educational Resources Information Center

    Nelms, Charlie; And Others

    1982-01-01

    Investigated impact of socio-economic status (SES) and achievement scores on job choice for 128 participants in a Labor Market Orientation Training program. Neither SES nor the program measure ("World of Work") were significant, but "Wide Range Achievement Test" gain scores did significantly impact on job choice. (Author/BRR)

  3. Social Adaptation and Its Relationship to Achievement Motivation among High School Students in Jordan

    ERIC Educational Resources Information Center

    AlZboon, Saleem Odeh

    2013-01-01

    The study amid at exploring and detecting the level of social adaptation and its relationship with the achievement motivation of the secondary school students in Jordan, the study sample consisted of 495 secondary school students in the province of Jerash, and to achieve the objective of this study comes the development of two tools: the first one…

  4. Achievement Goal Validation among African American High School Students: CFA and Rasch Results

    ERIC Educational Resources Information Center

    Hart, Caroline O.; Mueller, Christian E.; Royal, Kenneth D.; Jones, Martin H.

    2013-01-01

    Achievement goal theory helps describe how and why students engage in various academic behaviors. Historically, achievement goals have been examined almost exclusively with undergraduate, nonminority samples, and predominately with factor analytic techniques. The present study adds to a growing literature by providing initial validation of a…

  5. Longitudinal Analysis of Chinese High School Student's Stress in School and Academic Achievement

    ERIC Educational Resources Information Center

    Liu, Yangyang; Lu, Zuhong

    2011-01-01

    In previous research, few studies have examined the effects of adolescents' stress in school on the change rates of their academic achievement. In the present study, we seek to examine the longitudinal relationships between adolescents' stress in school and the change rates of their academic achievement. The results indicated that for those whose…

  6. Growth and Achievement Trends of Advanced Placement (AP) Exams in American High Schools

    ERIC Educational Resources Information Center

    Judson, Eugene; Hobson, Angela

    2015-01-01

    This exploratory study examined and compared overall trends in growth and student achievement of the Advanced Placement (AP) program. Using data from the past two decades, analyses indicated there has been steady and extensive growth of AP participation, particularly among underclassmen and some minority groups. However, overall achievement, as…

  7. An Examination of Paternal Influence on High-Achieving Gifted Males

    ERIC Educational Resources Information Center

    Hebert, Thomas P.; Pagnani, Alexander R.; Hammond, Daniel R.

    2009-01-01

    The challenges facing contemporary boys are complex, highlighting the importance of positive paternal influence for young men to achieve success. This study examines the father-son relationships of 10 prominent gifted men of achievement to identify factors influencing talent development. Through biographical analysis, 6 significant themes were…

  8. What’s Past is Prologue: Relations Between Early Mathematics Knowledge and High School Achievement

    PubMed Central

    Watts, Tyler W.; Duncan, Greg J.; Siegler, Robert S.; Davis-Kean, Pamela E.

    2015-01-01

    Although previous research has established the association between early-grade mathematics knowledge and later mathematics achievement, few studies have measured mathematical skills prior to school entry, nor have they investigated the predictive power of early gains in mathematics ability. The current paper relates mathematical skills measured at 54 months to adolescent mathematics achievement using multi-site longitudinal data. We find that preschool mathematics ability predicts mathematics achievement through age 15, even after accounting for early reading, cognitive skills, and family and child characteristics. Moreover, we find that growth in mathematical ability between age 54 months and first grade is an even stronger predictor of adolescent mathematics achievement. These results demonstrate the importance of pre-kindergarten mathematics knowledge and early math learning for later achievement. PMID:26806961

  9. Relationships of cognitive and metacognitive learning strategies to mathematics achievement in four high-performing East Asian education systems.

    PubMed

    Areepattamannil, Shaljan; Caleon, Imelda S

    2013-01-01

    The authors examined the relationships of cognitive (i.e., memorization and elaboration) and metacognitive learning strategies (i.e., control strategies) to mathematics achievement among 15-year-old students in 4 high-performing East Asian education systems: Shanghai-China, Hong Kong-China, Korea, and Singapore. In all 4 East Asian education systems, memorization strategies were negatively associated with mathematics achievement, whereas control strategies were positively associated with mathematics achievement. However, the association between elaboration strategies and mathematics achievement was a mixed bag. In Shanghai-China and Korea, elaboration strategies were not associated with mathematics achievement. In Hong Kong-China and Singapore, on the other hand, elaboration strategies were negatively associated with mathematics achievement. Implications of these findings are briefly discussed.

  10. Psychological maladjustment and academic achievement: a cross-cultural study of Japanese, Chinese, and American high school students.

    PubMed

    Crystal, D S; Chen, C; Fuligni, A J; Stevenson, H W; Hsu, C C; Ko, H J; Kitamura, S; Kimura, S

    1994-06-01

    Psychological maladjustment and its relation to academic achievement, parental expectations, and parental satisfaction were studied in a cross-national sample of 1,386 American, 1,633 Chinese, and 1,247 Japanese eleventh-grade students. 5 indices of maladjustment included measures of stress, depressed mood, academic anxiety, aggression, and somatic complaints. Asian students reported higher levels of parental expectation and lower levels of parental satisfaction concerning academic achievement than their American peers. Nevertheless, Japanese students reported less stress, depressed mood, aggression, academic anxiety, and fewer somatic complaints than did American students. Chinese students reported less stress, academic anxiety, and aggressive feelings than their American counterparts, but did report higher frequencies of depressed mood and somatic complaints. High academic achievement as assessed by a test of mathematics was generally not associated with psychological maladjustment. The only exception was in the United States, where high achievers indicated more frequent feelings of stress than did low achievers.

  11. Role of highly central residues of P-loop and it's flanking region in preserving the archetypal conformation of Walker A motif of diverse P-loop NTPases.

    PubMed

    Pathak, Ekta; Atri, Neelam; Mishra, Rajeev

    2013-01-01

    P-loop NTPases represent a large and highly diverse protein family that is involved in variety of cellular functions. Walker A motif forms a typical arched conformation, necessary to accommodate the phosphate moiety of the nucleoside tri (or di-) phosphate in Ploop NTPases. The feature that maintains the ancient architecture of P-loop is unidentified and uncharacterized. Here, using a well established global network parameter, closeness centrality, we identify that Walker A and its flanking regions (N- and C-terminal) have high density of globally connected residue positions. We find that closeness centrality of these residue positions are conserved across common structural core of diverse domains of P-loop NTPase fold. Our results suggest the potential role of globally connected residues in maintaining the local conformation of P-loop.

  12. Louisiana High School Weathers the Storm to Become a Leader in Student Achievement and High Graduation Rates. "High Schools That Work" Profile

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2011

    2011-01-01

    Warren Easton Charter High School in New Orleans, Louisiana, has weathered changes of many types, including Hurricane Katrina in 2005. After having to close for the 2005-2006 school year, the school reopened as a charter school with a board and stepped up its efforts to raise student achievement. Now the school is receiving attention for the…

  13. Anion control as a strategy to achieve high-mobility and high-stability oxide thin-film transistors.

    PubMed

    Kim, Hyun-Suk; Jeon, Sang Ho; Park, Joon Seok; Kim, Tae Sang; Son, Kyoung Seok; Seon, Jong-Baek; Seo, Seok-Jun; Kim, Sun-Jae; Lee, Eunha; Chung, Jae Gwan; Lee, Hyungik; Han, Seungwu; Ryu, Myungkwan; Lee, Sang Yoon; Kim, Kinam

    2013-01-01

    Ultra-definition, large-area displays with three-dimensional visual effects represent megatrend in the current/future display industry. On the hardware level, such a "dream" display requires faster pixel switching and higher driving current, which in turn necessitate thin-film transistors (TFTs) with high mobility. Amorphous oxide semiconductors (AOS) such as In-Ga-Zn-O are poised to enable such TFTs, but the trade-off between device performance and stability under illumination critically limits their usability, which is related to the hampered electron-hole recombination caused by the oxygen vacancies. Here we have improved the illumination stability by substituting oxygen with nitrogen in ZnO, which may deactivate oxygen vacancies by raising valence bands above the defect levels. Indeed, the stability under illumination and electrical bias is superior to that of previous AOS-based TFTs. By achieving both mobility and stability, it is highly expected that the present ZnON TFTs will be extensively deployed in next-generation flat-panel displays.

  14. Anion control as a strategy to achieve high-mobility and high-stability oxide thin-film transistors

    PubMed Central

    Kim, Hyun-Suk; Jeon, Sang Ho; Park, Joon Seok; Kim, Tae Sang; Son, Kyoung Seok; Seon, Jong-Baek; Seo, Seok-Jun; Kim, Sun-Jae; Lee, Eunha; Chung, Jae Gwan; Lee, Hyungik; Han, Seungwu; Ryu, Myungkwan; Lee, Sang Yoon; Kim, Kinam

    2013-01-01

    Ultra-definition, large-area displays with three-dimensional visual effects represent megatrend in the current/future display industry. On the hardware level, such a “dream” display requires faster pixel switching and higher driving current, which in turn necessitate thin-film transistors (TFTs) with high mobility. Amorphous oxide semiconductors (AOS) such as In-Ga-Zn-O are poised to enable such TFTs, but the trade-off between device performance and stability under illumination critically limits their usability, which is related to the hampered electron-hole recombination caused by the oxygen vacancies. Here we have improved the illumination stability by substituting oxygen with nitrogen in ZnO, which may deactivate oxygen vacancies by raising valence bands above the defect levels. Indeed, the stability under illumination and electrical bias is superior to that of previous AOS-based TFTs. By achieving both mobility and stability, it is highly expected that the present ZnON TFTs will be extensively deployed in next-generation flat-panel displays. PMID:23492854

  15. Closing the Academic Achievement Gap on the California High School Exit Exam (CAHSEE) through Professional Learning Communities (PLC) Characteristics

    ERIC Educational Resources Information Center

    Buenrostro, Samuel

    2012-01-01

    Purpose: The purpose of this study was to determine the degree of importance that DuFour's nine characteristics of highly effective schools have on closing the academic achievement gap on the California High School Exit Exam, as perceived by high school principals. The study also examined the strategies believed to be most important in developing…

  16. Replacement between conformity and counter-conformity in consumption decisions.

    PubMed

    Chou, Ting-Jui; Chang, En-Chung; Dai, Qi; Wong, Veronica

    2013-02-01

    This study assessed, in a Chinese context, how self-esteem interacts with perceived similarity and uniqueness to yield cognitive dissonance, and whether the dissonance leads to self-reported conformity or counter-conformity behavior. Participants were 408 respondents from 4 major Chinese cities (M age = 33.0 yr., SD = 4.3; 48% men). Self-perceptions of uniqueness, similarity, cognitive dissonance, self-esteem and need to behave in conformity or counter-conformity were measured. A theoretical model was assessed in four situations, relating the ratings of self-esteem and perceived similarity/uniqueness to the way other people at a wedding were dressed, and the resultant cognitive dissonance and conformity/ counter-conformity behavior. Regardless of high or low self-esteem, all participants reported cognitive dissonance when they were told that they were dressed extremely similarly to or extremely differently from the other people attending the wedding. However, the conforming/counter-conforming strategies used by participants to resolve the cognitive dissonance differed. When encountering dissonance induced by the perceived extreme uniqueness of dress, participants with low self-esteem tended to say they would dress next time so as to conform with the way others were dressed, while those with high self-esteem indicated they would continue their counter-conformity in attire. When encountering dissonance induced by the perceived extreme similarity to others, both those with high and low self-esteem tended to say they would dress in an unorthodox manner to surprise other people in the future.

  17. Investigation of Ag-TiO2 Interfacial Reaction of Highly Stable Ag Nanowire Transparent Conductive Film with Conformal TiO2 Coating by Atomic Layer Deposition.

    PubMed

    Yeh, Ming-Hua; Chen, Po-Hsun; Yang, Yi-Ching; Chen, Guan-Hong; Chen, Hsueh-Shih

    2017-03-29

    The atomic layer deposition (ALD) technique is applied to coat Ag nanowires (NWs) with a highly uniform and conformal TiO2 layer to improve the stability and sustainability of Ag NW transparent conductive films (TCFs) at high temperatures. The TiO2 layer can be directly deposited on Ag NWs with a surface polyvinylpyrrolidone (PVP) coat that acts a bed for TiO2 seeding in the ALD process. The ALD TiO2 layer significantly enhances the thermal stability at least 100 fold when aged between 200-400 °C and also provides an extra function of violet-blue light filtration for Ag NW TCFs. Investigation into the interaction between TiO2 and Ag reveals that the conformal TiO2 shell could effectively prevent Ag from 1D-to-3D ripening. However, Ag could penetrate the conformal TiO2 shell and form nanocrystals on the TiO2 shell surface when it is aged at 400 °C. According to experimental data and thermodynamic evaluation, the Ag penetration leads to an interlayer composed of mixed Ag-Ag2O-amorphous carbon phases and TiO2-x at the Ag-TiO2 interface, which is thought to be caused by extremely high vapor pressure of Ag at the Ag-TiO2 interface at a higher temperature (e.g., 400 °C).

  18. Raising the stakes: How students' motivation for mathematics associates with high- and low-stakes test achievement.

    PubMed

    Simzar, Rahila M; Martinez, Marcela; Rutherford, Teomara; Domina, Thurston; Conley, AnneMarie M

    2015-04-01

    This study uses data from an urban school district to examine the relation between students' motivational beliefs about mathematics and high- versus low-stakes math test performance. We use ordinary least squares and quantile regression analyses and find that the association between students' motivation and test performance differs based on the stakes of the exam. Students' math self-efficacy and performance avoidance goal orientation were the strongest predictors for both exams; however, students' math self-efficacy was more strongly related to achievement on the low-stakes exam. Students' motivational beliefs had a stronger association at the low-stakes exam proficiency cutoff than they did at the high-stakes passing cutoff. Lastly, the negative association between performance avoidance goals and high-stakes performance showed a decreasing trend across the achievement distribution, suggesting that performance avoidance goals are more detrimental for lower achieving students. These findings help parse out the ways motivation influences achievement under different stakes.

  19. Direct tumor in vivo dosimetry in highly-conformal radiotherapy: A feasibility study of implantable MOSFETs for hypofractionated extracranial treatments using the Cyberknife system

    SciTech Connect

    Scalchi, Paolo; Righetto, Roberto; Cavedon, Carlo; Francescon, Paolo; Colombo, Federico

    2010-04-15

    Purpose: In highly-conformal radiotherapy, due to the complexity of both beam configurations and dose distributions, traditional in vivo dosimetry is unpractical or even impossible. The ideal dosimeter would be implanted inside the planning treatment volume so that it can directly measure the total delivered dose during each fraction with no additional uncertainty due to calculation models. The aim of this work is to verify if implantable metal oxide semiconductors field effect transistors (MOSFETs) can achieve a sufficient degree of dosimetric accuracy when used inside extracranial targets undergoing radiotherapy treatments using the Cyberknife system. Methods: Based on the preliminary findings of this study, new prototypes for high dose fractionations were developed to reduce the time dependence for long treatment delivery times. These dosimeters were recently cleared and are marketed as DVS-HFT. Multiple measurements were performed using both Virtual Water and water phantoms to characterize implantable MOSFETs under the Cyberknife beams, and included the reference-dosimetry consistency, the dependence of the response on the collimator size, on the daily delivered dose, and the time irradiation modality. Finally a Cyberknife prostate treatment simulation using a body phantom was conducted, and both MOSFET and ionization readings were compared to Monte Carlo calculations. The feasibility analysis was conducted based on the ratios of the absorbed dose divided by the dose reading, named as ''further calibration factor'' (FCF). Results: The average FCFs resulted to be 0.98 for the collimator dependence test, and about 1.00 for the reference-dosimetry test, the dose-dependence test, and the time-dependence test. The average FCF of the prostate treatment simulation test was 0.99. Conclusions: The obtained results are well within DVS specifications, that is, the factory calibration is still valid for such kind of treatments using the Cyberknife system, with no need of

  20. A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution

    SciTech Connect

    Pallan, Pradeep S.; Prakash, Thazha P.; Li, Feng; Eoff, Robert L.; Manoharan, Muthiah; Egli, Martin

    2009-06-17

    Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.

  1. Influence of Strategy of Learning and Achievement Motivation of Learning Achievement Class VIII Students of State Junior High School in District Blitar

    ERIC Educational Resources Information Center

    Ayundawati, Dyah; Setyosari, Punaji; Susilo, Herawati; Sihkabuden

    2016-01-01

    This study aims for know influence of problem-based learning strategies and achievement motivation on learning achievement. The method used in this research is quantitative method. The instrument used in this study is two fold instruments to measure moderator variable (achievement motivation) and instruments to measure the dependent variable (the…

  2. The statistical conformation of a highly flexible protein: small-angle X-ray scattering of S. aureus protein A.

    PubMed

    Capp, Jo A; Hagarman, Andrew; Richardson, David C; Oas, Terrence G

    2014-08-05

    Staphylococcal protein A (SpA) is a multidomain protein consisting of five globular IgG binding domains separated by a conserved six- to nine-residue flexible linker. We collected SAXS data on the N-terminal protein-binding half of SpA (SpA-N) and constructs consisting of one to five domain modules in order to determine statistical conformation of this important S. aureus virulence factor. We fit the SAXS data to a scattering function based on a new polymer physics model, which provides an analytical description of the SpA-N statistical conformation. We describe a protocol for systematically determining the appropriate level of modeling to fit a SAXS data set based on goodness of fit and whether the addition of parameters improves it. In the case of SpA-N, the analytical polymer physics description provides a depiction of the statistical conformation of a flexible protein that, while lacking atomistic detail, properly reflects the information content of the data.

  3. Academic Achievement Trajectories of Homeless and Highly Mobile Students: Resilience in the Context of Chronic and Acute Risk

    PubMed Central

    Cutuli, J. J.; Desjardins, Christopher David; Herbers, Janette E.; Long, Jeffrey D.; Heistad, David; Chan, Chi-Keung; Hinz, Elizabeth; Masten, Ann S.

    2012-01-01

    Analyses examined academic achievement data across 3rd through 8th grades (N = 26,474), comparing students identified as homeless or highly mobile (HHM) to other students in the federal free meal program (FM), reduced-price meals (RM), or neither (General). Achievement was lower as a function of rising risk status (General > RM > FM > HHM). Achievement gaps appeared stable or widened between HHM students and lower-risk groups. Math and reading achievement were lower and growth in math was slower in years of HHM identification, suggesting acute consequences of residential instability. Nonetheless, 45% of HHM students scored within or above the average range, suggesting academic resilience. Results underscore the need for research on risk and resilience processes among HHM students to address achievement disparities. PMID:23110492

  4. The Predictive Relation of a High School Mathematic GPA to High-Stakes Assessment Achievement Scores in Mathematics

    ERIC Educational Resources Information Center

    West, Suzanne M.

    2013-01-01

    Course grades, which often include non-achievement factors such as effort and behavior and are subject to individual teacher grading philosophies, suffer from issues of unreliability. Yet, course grades continue to be utilized as a primary tool for reporting academic achievement to students and parents and are used by most colleges and…

  5. Achievement Emotions as Predictors of High School Science Success Among African-American and European American Students

    NASA Astrophysics Data System (ADS)

    Bowe, Marilyn Louise Simmons

    The literature includes few studies of the interrelations of achievement goals and achievement emotions with respect to minority students and science achievement. The objective of this study was to test the control-value theory (CVT) of achievement emotions to determine if the eight discrete achievement emotions would be predictive of test scores on the High School Graduation Test (GHSGT)-Science for African-American compared to European-American science students. Convenience cluster sampling was employed to select 160 students who were all juniors in the same public high school at the time that they took the GHSGT-Science. The central research question for this study aimed to uncover whether any of the eight achievement emotions identified in CVT would contribute significantly to the predictability of science achievement as measured by GHSGT-Science scores. Data were collected using a nonexperimental, cross sectional design survey. Data were analyzed using a hierarchal, forced entry, multiple regression analysis. Key results indicated that the eight achievement emotions were predictive of GHSGT-Science score outcomes. Positive social change at the individual level could reflect a boost in confidence for African American science students and help decrease the achievement gap in science, technology, engineering, and mathematics (STEM) endeavors between European Americans and African-American students. Educators may consider the importance of achievement emotions in science outcomes by including social emotional learning (SEL) as a part of the regular science curriculum. Future researchers should repeat the study in a school district where the population is available to support the desired cluster sample of equal parts European Americans to African Americans and male to female students.

  6. Behavior problems at ages 6 and 11 and high school academic achievement: longitudinal latent variable modeling.

    PubMed

    Breslau, Naomi; Breslau, Joshua; Miller, Elizabeth; Raykov, Tenko

    2011-02-28

    Previous studies documented long-run effects of behavior problems at the start of school on academic achievement. However, these studies did not examine whether the observed effects of early behavior problems are explained by more proximate behavior problems, given the tendency of children's behavior problems to persist. Latent variable modeling was applied to estimate the effects of behavior problems at ages 6 and 11 on academic achievement at age 17, using data from a longitudinal study (n=823). Behavior problems at ages 6 and 11, each stage independently of the other, predicted lower math and reading test scores at age 17, controlling for intelligence quotient (IQ), birth weight, maternal characteristics, family and community environment, and taking into account behavior problems at age 17. Behavior problems at the start of school, independent of later behavior problems, exert lingering effects on achievement by impeding the acquisition of cognitive skills that are the foundation for later academic progress.

  7. A Study of the Academic Achievement, Attrition and Group Reactions of High School Equivalency Students Attending Brandon University.

    ERIC Educational Resources Information Center

    Colert, Sherril

    The academic achievement and attrition of high school equivalency students attending Brandon University, a small undergraduate Canadian university, were studied, as were the students' reactions to college life. The students, who received a high school equivalency certificate after completing the Tests of General Educational Development (GED), were…

  8. High-Stakes Tests: Comparative Study Examining the Impact on the Achievement Gap that Causes Minority Students Continued Failure

    ERIC Educational Resources Information Center

    Taylor-Smith, Carol J.

    2011-01-01

    The purpose of this comparative qualitative study examined the impact of the achievement gap on the lack of highly qualified teachers instructing African American students consistently from K-12th grades and its effects on high-stakes testing. In addition, the study examined teacher perceptions that could also be contributing factors of the…

  9. The Relationship of Mental Pressure with Optimism and Academic Achievement Motivation among Second Grade Male High School Students

    ERIC Educational Resources Information Center

    Sarouni, Ali Sedigh; Jenaabadi, Hossein; Pourghaz, Abdulwahab

    2016-01-01

    The present study aimed to examine the relationship of mental pressure with optimism and academic achievement motivation among second grade second period male high school students. This study followed a descriptive-correlational method. The sample included 200 second grade second period male high school students in Sooran. Data collection tools in…

  10. Gender Differences in Korean High School Students' Science Achievements and Attitudes towards Science in Three Different School Settings

    ERIC Educational Resources Information Center

    Bang, EunJin; Baker, Dale R.

    2013-01-01

    This study analysed the effect of high schools' gender organization on Korean tenth-grade students' science achievements, and their attitudes towards science. The high schools involved included an all-male institution, an all-female institution, and a co-educational institution. Three schools, three principals, three science teachers, and 302…

  11. The Influence of the Antecedent Variable on the Teachers' Performance through Achievement Motivation in Senior High School

    ERIC Educational Resources Information Center

    Dewi, Erni R.; Bundu, Patta; Tahmir, Suradi

    2016-01-01

    This study aims at analysing whether the antecedent variable directly affects the performance of the high school teachers or not. In addition, this research strives to find out whether the antecedent variable indirectly affects the teachers' performance through the achievement motivation of the high school teachers. It was a quantitative research…

  12. A Descriptive Study of High School Latino and Caucasian Students' Values about Math, Perceived Math Achievement and STEM Career Choice

    ERIC Educational Resources Information Center

    Rodriguez Flecha, Samuel

    2012-01-01

    The purpose of this study was to examine high school students' math values, perceived math achievement, and STEM career choice. Participants (N=515) were rural high school students from the U.S. Northwest. Data was collected by administering the "To Do or Not to Do:" STEM pilot survey. Most participants (n=294) were Latinos, followed by…

  13. Big School, Small School: (Re)Testing Assumptions about High School Size, School Engagement and Mathematics Achievement

    ERIC Educational Resources Information Center

    Weiss, Christopher C.; Carolan, Brian V.; Baker-Smith, E. Christine

    2010-01-01

    In an effort to increase both adolescents' engagement with school and academic achievement, school districts across the United States have created small high schools. However, despite the widespread adoption of size reduction reforms, relatively little is known about the relationship between size, engagement and outcomes in high school. In…

  14. The Effects of College Counseling on High-Achieving, Low-Income Students. NBER Working Paper No. 16359

    ERIC Educational Resources Information Center

    Avery, Christopher

    2010-01-01

    This paper reports the results of a pilot study, using a randomized controlled trial to provide college counseling to high-achieving students from relatively poor families. We followed 107 high school seniors through the college admissions process in 2006-2007; we selected 52 of these students at random, offering them ten hours of individualized…

  15. The Grasshopper and the Ant: Motivational Responses of Low-Achieving Students to High-Stakes Testing.

    ERIC Educational Resources Information Center

    Roderick, Melissa; Engel, Mimi

    2001-01-01

    Examined the responses of 102 low achieving sixth and eighth graders to Chicago's highly publicized efforts to end social promotion. Students generally described increased work efforts, and students with high levels of work effort generally had greater than average learning gains and positive outcomes in terms of promotion. About one-third of…

  16. The Effect of Community Linguistic Isolation on Language-Minority Student Achievement in High School

    ERIC Educational Resources Information Center

    Drake, Timothy Arthur

    2014-01-01

    Research on language-minority student outcomes has revealed sizeable and persistent achievement gaps. The reasons for these gaps are often closely linked with other factors related to underperformance, including generational status, race/ethnicity, and socioeconomic status. Using sociocultural second-language acquisition theories and community…

  17. Sustaining Success toward Closing the Achievement Gap: A Case Study of One Urban High School

    ERIC Educational Resources Information Center

    Cabrera, Kimberly Elizabeth

    2010-01-01

    Since the introduction of the Coleman Report (1966), the focus on closing the achievement gap has been a critical component of educational policy for political leaders and field research by educators. The economic crisis which California and the nation at large currently face creates a challenging situation in attempting to narrow the gap.…

  18. Effect of Blended Learning Environment Model on High School Students' Academic Achievement

    ERIC Educational Resources Information Center

    Kazu, Ibrahim Yasar; Demirkol, Mehmet

    2014-01-01

    This study analyzes the students' academic performance by comparing the blended learning environment and traditional learning environment. It has been observed whether there is a significant difference between the academic achievement grade dispersions and the male-female students' grades. The study has been carried out in Diyarbakir Anatolian…

  19. Relationship between Grade One Achievement and Academic Performance through High School.

    ERIC Educational Resources Information Center

    Simner, Marvin L.; Barnes, Michael J.

    The major purpose of this study was to determine what relationship currently exists between grade 1 marks and later school achievement. Complete academic records were obtained on two samples of students from rural towns in Southwestern Ontario. Each sample contained all the children born between 1964 and 1971 who attended their town's major public…

  20. The Influence of Mathematics Anxiety in Middle and High School Students Math Achievement

    ERIC Educational Resources Information Center

    Al Mutawah, Masooma Ali

    2015-01-01

    Math anxiety has been the focus of much psychological and educational research in the past few years, there are many international studies showing that mathematics anxiety is an influence on student's achievements in school, but little research has been done about this issue in Bahrain. Bahrain is a country in the Arabian Gulf region, its economic…

  1. Mathematically Gifted Students and High Achievement: The Role of Motivation and Classroom Structure

    ERIC Educational Resources Information Center

    Lüftenegger, Marko; Kollmayer, Marlene; Bergsmann, Evelyn; Jöstl, Gregor; Spiel, Christiane; Schober, Barbara

    2015-01-01

    One of the most intriguing questions for those who study intellectually gifted students is why some of them reach peak performances at school and others don't. Moderator theories of giftedness assume that domain-specific gifts are transformed into achievement in a process influenced by non-cognitive and environmental variables. Thus, the current…

  2. Faculty Sense of Academic Optimism and Its Relationship to Students' Achievement in Well Performing High Schools

    ERIC Educational Resources Information Center

    Cromartie, Michael Tyrone

    2013-01-01

    The aim of this study was to determine the organizational characteristics and behaviors that contribute to sustaining a culture of academic optimism as a mechanism of student achievement. While there is a developing research base identifying both the individual elements of academic optimism as well as the academic optimism construct itself as…

  3. MOTIVATIONAL FACTORS INFLUENCING ACADEMIC ACHIEVEMENT OF ELEVENTH GRADE PUERTO RICAN HIGH SCHOOL STUDENTS.

    ERIC Educational Resources Information Center

    FARQUHAR, WILLIAM M.; CHRISTENSEN, EDWARD W.

    THIS STUDY INVOLVED--(1) EXPLORING ACADEMIC MOTIVATIONAL FACTORS IN PUERTO RICAN 11TH-GRADE STUDENTS, (2) CREATING A MEASURE FOR THESE FACTORS WHICH MIGHT BE USABLE IN OTHER LATIN AMERICAN AREAS, AND (3) INVESTIGATING THE CHILD-REARING AND OTHER PSYCHO-SOCIAL FACTORS RELATED TO ACADEMIC ACHIEVEMENT. THE METHOD INVOLVED THREE STAGES--(1)…

  4. Academic Achievement of High School Students in Relation to Their Anxiety, Emotional Maturity and Social Maturity

    ERIC Educational Resources Information Center

    Puar, Surjit Singh

    2013-01-01

    The present study has been designed to investigate the non-cognitive variables like anxiety, emotional maturity and social maturity and their relationship with academic achievement and also to see the locale-wise differences on the basis of their anxiety, emotional maturity and social maturity. The study was conducted over a sample of 400 (200…

  5. Unequal Academic Achievement in High School: The Mediating Roles of Concerted Cultivation and Close Friends

    ERIC Educational Resources Information Center

    Carolan, Brian V.

    2016-01-01

    Building from the classic Wisconsin model of status attainment, this study examines whether a specific style of parenting, concerted cultivation, and a close friend's school-related attitudes and behaviors mediate the relationship between a family's socioeconomic status and their child's academic achievement in the United States. Using a recursive…

  6. Teacher Commitment and Its Effects on Student Achievement in American High Schools

    ERIC Educational Resources Information Center

    Park, Insim

    2005-01-01

    This study explored the effects of teacher commitment on student achievement. Three teacher commitment dimensions of organizational, professional, and student commitment were derived. The three-dimensional teacher commitment measurement model was tested by a confirmatory factor analysis. Then, the relationships among individual and organizational…

  7. High School Teachers' Perceptions of School Change and Its Implications for Student Achievement

    ERIC Educational Resources Information Center

    Mitchell, Anthony J.

    2010-01-01

    This study attempted to observe if there was a statistical significant relationship between perceptions of educational change and student achievement. The independent variables that represented perceptions of educational change included: community pressure for change, faculty anxiety to change, faculty openness to change, principal anxiety to…

  8. Comprehensive Achievement Monitoring in the Sequoia Union High School District. Symposium, California Mathematics Council Northern Section.

    ERIC Educational Resources Information Center

    Easter, John; And Others

    A description is provided of comprehensive Achievement Monitoring (CAM), a tool which enables classroom teachers to function as researchers and evaluators. Part I reviews the CAM philosophy and the section following discusses computerized feedback in CAM operations. The final two portions of the report describes the use of CAM in mathematics…

  9. Analyzing Academic Achievement of Junior High School Students by an Improved Rough Set Model

    ERIC Educational Resources Information Center

    Pai, Ping-Feng; Lyu, Yi-Jia; Wang, Yu-Min

    2010-01-01

    Rough set theory (RST) is an emerging technique used to deal with problems in data mining and knowledge acquisition. However, the RST approach has not been widely explored in the field of academic achievement. This investigation developed an improved RST (IMRST) model, which employs linear discriminant analysis to determine a reduct of RST, and…

  10. Differential Effects of Organizational Processes on High and Low Achieving Students.

    ERIC Educational Resources Information Center

    Madhere, Serge; Azumi, Jann

    Pupils, teachers, and principals in urban elementary schools were interviewed to determine how administrative leadership styles and types of feedback mechanisms affect the academic achievement of two groups of pupils: those enrolled in Title I remedial reading programs, and those enrolled in the regular curriculum. Two components of administrative…

  11. Three Dopaminergic Polymorphisms Are Associated with Academic Achievement in Middle and High School

    ERIC Educational Resources Information Center

    Beaver, Kevin M.; Vaughn, Michael G.; Wright, John Paul; DeLisi, Matt; Howard, Matthew O.

    2010-01-01

    Although academic achievement is a heritable construct, to date research has yet to explore its molecular genetic underpinnings. Drawing on data from the National Longitudinal Study of Adolescent Health, the current longitudinal study investigated the associations between polymorphisms in three dopaminergic genes (DAT1, DRD2, and DRD4) and…

  12. Factors Influencing Student Achievement at a High-Performing Title I Elementary School

    ERIC Educational Resources Information Center

    Neimeier, Charlann K.

    2012-01-01

    Schools in America are required to provide all students with a quality education regardless of race, ethnicity, or socioeconomic background, demonstrated through test scores mandated by the No Child Left Behind Act. Knowledge about factors that influence students' academic performance and serve to reduce the achievement gap between Hispanic…

  13. Schools Raise Achievement by Setting High Expectations for All Groups of Students

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2009

    2009-01-01

    Schools are raising standards to improve academic and technical achievement and intellectual growth for all groups of students, particularly at-risk students. This newsletter contains tools and strategies that school leaders and teachers are using successfully to help students meet higher expectations. It organizes the techniques into five…

  14. Self-Regulation, Executive Function, Working Memory, and Academic Achievement of Female High School Students

    ERIC Educational Resources Information Center

    Halloran, Roberta Kathryn

    2011-01-01

    Self-regulation, executive function and working memory are areas of cognitive processing that have been studied extensively. Although many studies have examined the constructs, there is limited empirical support suggesting a formal link between the three cognitive processes and their prediction of academic achievement. Thus, the present study…

  15. Impacts of Comprehensive Reading Instruction on Diverse Outcomes of Low- and High-Achieving Readers

    ERIC Educational Resources Information Center

    Guthrie, John T.; McRae, Angela; Coddington, Cassandra S.; Klauda, Susan Lutz; Wigfield, Allan; Barbosa, Pedro

    2009-01-01

    Low-achieving readers in Grade 5 often lack comprehension strategies, domain knowledge, word recognition skills, fluency, and motivation to read. Students with such multiple reading needs seem likely to benefit from instruction that supports each of these reading processes. The authors tested this expectation experimentally by comparing the…

  16. The Role of Schools, Families, and Psychological Variables on Math Achievement of Black High School Students

    ERIC Educational Resources Information Center

    Strayhorn, Terrell L.

    2010-01-01

    Using data from the National Education Longitudinal Study (NELS;1988/2000), the author conducted hierarchical linear regression analyses, with a nested design, to estimate the influence of affective variables--parent involvement, teacher perceptions, and school environments--on Black students' math achievement in grade 10. Drawing on…

  17. Highly Qualified Teacher Status and the Reading Achievement of Students with Disabilities

    ERIC Educational Resources Information Center

    Robinson, Helene

    2011-01-01

    The purpose of this study was to examine teacher qualification factors believed to affect reading achievement of students with disabilities in intensive reading classes after controlling for certain student and teacher demographics using ANCOVA. Results indicated that there was no statistically significant difference between the reading…

  18. The Contribution of Cultural Capital to Students' Mathematics Achievement in Medium and High Socioeconomic Gradient Economies

    ERIC Educational Resources Information Center

    Tan, Cheng Yong

    2015-01-01

    The present study addresses the issue of how different forms of cultural capital may influence children's mathematics achievement in economies with different socioeconomic gradients. Data from 73,178 parent-child dyads from 10 economies with different socioeconomic gradients who participated in the Programme for International Student Assessment…

  19. A Qualitative Study of High Student Achievement in a Rural Appalachian Region: Perceptions of Selected Superintendents

    ERIC Educational Resources Information Center

    Mathis, Regina

    2011-01-01

    This qualitative study was based on grounded theory and used purposive sampling for selecting participants. The sample for this study included 12 of the 16 superintendents in this region. This rural Appalachian region has historically outperformed the remainder of the southeastern state on reading and math achievement tests at the elementary and…

  20. Transition from High School to University: A Person-Centered Approach to Academic Achievement

    ERIC Educational Resources Information Center

    De Clercq, Mikaël; Galand, Benoît; Frenay, Mariane

    2017-01-01

    Although a vast body of studies regarding the variables related to students' achievement exists, only a handful has investigated how these variables combine and interact together. Such an investigation might make it possible to more accurately illustrate the heterogeneity of students enrolling in university and assess the impact of this diversity…

  1. Low-Achieving Readers, High Expectations: Image Theatre Encourages Critical Literacy

    ERIC Educational Resources Information Center

    Rozansky, Carol Lloyd; Aagesen, Colleen

    2010-01-01

    Students in an eighth-grade, urban, low-achieving reading class were introduced to critical literacy through engagement in Image Theatre. Developed by liberatory dramatist Augusto Boal, Image Theatre gives participants the opportunity to examine texts in the triple role of interpreter, artist, and sculptor (i.e., image creator). The researchers…

  2. The Relationship of Grade Span in 9th Grade to Math Achievement in High School

    ERIC Educational Resources Information Center

    West, John; Miller, Mary Lou; Myers, Jim; Norton, Timothy

    2015-01-01

    Purpose, Scope, and Method of Study: The purpose of this study was to determine if a correlation exists between grade span for ninth grade and gains in math achievement test scores in 10th grade and 12th grade. A quantitative, longitudinal, correlational research design was employed to investigate the research questions. The population was high…

  3. Conformers, infrared spectrum, UV-induced photochemistry, and near-IR-induced generation of two rare conformers of matrix-isolated phenylglycine

    NASA Astrophysics Data System (ADS)

    Borba, Ana; Gómez-Zavaglia, Andrea; Fausto, Rui

    2014-10-01

    The conformational space of α-phenylglycine (PG) have been investigated theoretically at both the DFT/B3LYP/6-311++G(d,p) and MP2/6-311++G(d,p) levels of approximation. Seventeen different minima were found on the investigated potential energy surfaces, which are characterized by different dominant intramolecular interactions: type I conformers are stabilized by hydrogen bonds of the type N-H...O=C, type II by a strong O-H...N hydrogen bond, type III by weak N-H...O-H hydrogen bonds, and type IV by a C=O...H-C contact. The calculations indicate also that entropic effects are relevant in determining the equilibrium populations of the conformers of PG in the gas phase, in particular in the case of conformers of type II, where the strong intramolecular O-H...N hydrogen bond considerably diminishes entropy by reducing the conformational mobility of the molecule. In consonance with the relative energies of the conformers and barriers for conformational interconversion, only 3 conformers of PG were observed for the compound isolated in cryogenic Ar, Xe, and N2 matrices: the conformational ground state (ICa), and forms ICc and IITa. All other significantly populated conformers existing in the gas phase prior to deposition convert either to conformer ICa or to conformer ICc during matrix deposition. The experimental observation of ICc had never been achieved hitherto. Narrowband near-IR irradiation of the first overtone of νOH vibrational mode of ICa and ICc in nitrogen matrices (at 6910 and 6930 cm-1, respectively) led to selective generation of two additional conformers of high-energy, ITc and ITa, respectively, which were also observed experimentally for the first time. In addition, these experiments also provided the key information for the detailed vibrational characterization of the 3 conformers initially present in the matrices. On the other hand, UV irradiation (λ = 255 nm) of PG isolated in a xenon matrix revealed that PG undergoes facile photofragmentation

  4. Conformers, infrared spectrum, UV-induced photochemistry, and near-IR-induced generation of two rare conformers of matrix-isolated phenylglycine

    SciTech Connect

    Borba, Ana Fausto, Rui; Gómez-Zavaglia, Andrea

    2014-10-21

    The conformational space of α-phenylglycine (PG) have been investigated theoretically at both the DFT/B3LYP/6-311++G(d,p) and MP2/6-311++G(d,p) levels of approximation. Seventeen different minima were found on the investigated potential energy surfaces, which are characterized by different dominant intramolecular interactions: type I conformers are stabilized by hydrogen bonds of the type N–H···O=C, type II by a strong O–H···N hydrogen bond, type III by weak N–H···O–H hydrogen bonds, and type IV by a C=O···H–C contact. The calculations indicate also that entropic effects are relevant in determining the equilibrium populations of the conformers of PG in the gas phase, in particular in the case of conformers of type II, where the strong intramolecular O–H···N hydrogen bond considerably diminishes entropy by reducing the conformational mobility of the molecule. In consonance with the relative energies of the conformers and barriers for conformational interconversion, only 3 conformers of PG were observed for the compound isolated in cryogenic Ar, Xe, and N{sub 2} matrices: the conformational ground state (ICa), and forms ICc and IITa. All other significantly populated conformers existing in the gas phase prior to deposition convert either to conformer ICa or to conformer ICc during matrix deposition. The experimental observation of ICc had never been achieved hitherto. Narrowband near-IR irradiation of the first overtone of νOH vibrational mode of ICa and ICc in nitrogen matrices (at 6910 and 6930 cm{sup −1}, respectively) led to selective generation of two additional conformers of high-energy, ITc and ITa, respectively, which were also observed experimentally for the first time. In addition, these experiments also provided the key information for the detailed vibrational characterization of the 3 conformers initially present in the matrices. On the other hand, UV irradiation (λ = 255 nm) of PG isolated in a xenon matrix revealed that

  5. Detection of Short-Range DNA Interactions in Mammalian Cells Using High-Resolution Circular Chromosome Conformation Capture Coupled to Deep Sequencing.

    PubMed

    Millau, Jean-François; Gaudreau, Luc

    2015-01-01

    DNA interactions shape the genome to physically and functionally connect regulatory elements to their target genes. Studying these interactions is crucial to understanding the molecular mechanisms that regulate gene expression. In this chapter, we present a protocol for high-resolution circular chromosome conformation capture coupled to deep sequencing. This methodology allows to investigate short-range DNA interactions (<100 kbp) and to obtain high-resolution DNA interaction maps of loci. It is a powerful tool to explore how regulatory elements and genes are connected together.

  6. Academic achievement, violent victimization, and bullying among U.S. high school students.

    PubMed

    Hammig, Bart; Jozkowski, Kristen

    2013-05-01

    The authors examined the relationship between adolescents' experiences with violent victimization and academic achievement. Data from the 2009 Youth Risk Behavior Survey were analyzed for males (N = 8,537) and females (N = 7,816). Multinomial logistic regression analyses were employed to estimate the relationship between academic achievement and violent victimization. Among males and females, 6.6% and 4.4%, respectively, earned grades of mostly Ds or Fs during the past year. Among males, those earning mostly Ds or Fs had an increased odds of having been injured in a fight (adjusted odds ratio [OR] = 2.2, 95% confidence interval [95% CI]: 1.5-3.3) or threatened at school (OR = 2.0, 95% CI: 1.3-2.9) when compared to males who earned mostly As or Bs. Moreover, those who earned mostly Cs were at increased odds of having been threatened at school when compared to males who earned mostly As or Bs (OR = 1.4, 95% CI: 1.1-1.9). Among females, those earning mostly Ds or Fs had a higher odds of having been bullied at school (OR = 1.6, 95% CI: 1.1-2.3 ), threatened at school (OR = 1.5, 95% CI: 1.1-2.3), or violently victimized by an intimate partner (OR = 2.0, 95% CI: 1.4-3.0) when compared to females who earned mostly As or Bs. Similar findings were observed when examining females earning mostly C grades. Academic achievement is linked to victimization patterns among male and female adolescents. Although the temporality of the relationship is unclear, the strength of the associations increase as academic achievement decreases.

  7. Effect of Direct Teaching Method on the Academic Achievement of High and Low Achievers in the Subject of English at the Secondary Level

    ERIC Educational Resources Information Center

    Hussain, Ishtiaq; Hamdani, Syed Nisar Hussain; Quraishi, Uzma; Zeeshan, Muhammad

    2010-01-01

    The major objective of the study was to determine the role of the direct teaching method in the academic achievement of students in English at the secondary level. To achieve the said objective, the Solomon Four-Design pre-test/post-test equivalent group design was considered to be the most useful design for this study. The pre-test was used to…

  8. Beating the Odds: The Real Challenges behind the Math Achievement Gap--And What High-Achieving Schools Can Teach Us about How to Close It

    ERIC Educational Resources Information Center

    Goldberger, Susan

    2008-01-01

    One of the most persistent inequities in U.S. education is the gap in math achievement along income and race lines. Yet some secondary schools beat the odds, producing consistently strong math performance with students who likely would fail in traditional settings. This report advocates that the math achievement gap is not the result of poor and…

  9. Inquiry-Based Laboratory Activities in Electrochemistry: High School Students' Achievements and Attitudes

    ERIC Educational Resources Information Center

    Sesen, Burcin Acar; Tarhan, Leman

    2013-01-01

    This study aimed to investigate the effects of inquiry-based laboratory activities on high school students' understanding of electrochemistry and attitudes towards chemistry and laboratory work. The participants were 62 high school students (average age 17 years) in an urban public high school in Turkey. Students were assigned to experimental (N =…

  10. Six Challenges Are Key for High-Performing Schools that Aim to Achieve More

    ERIC Educational Resources Information Center

    Ray-Taylor, Rossi; Baskerville, Sharon; Bruder, Shelley; Bennett, Elaine; Schulte, Karen

    2006-01-01

    Across the US, some schools are hallmarks of high academic performance. These schools display consistently high test performance, and their students are sought after by competitive colleges and universities. These schools are successful, with consistently above-average test scores, low dropout rates, high percentages of children attending college,…

  11. Short Circuits or Superconductors? Effects of Group Composition on High-Achieving Students' Science Assessment Performance.

    ERIC Educational Resources Information Center

    Webb, Noreen M.; Nemer, Kariane Mari; Zuniga, Stephen

    2002-01-01

    Studied the effects of group ability composition (homogeneous versus heterogeneous) on group processes and outcomes for high-ability students completing science assessments. Results for 83 high ability students show the quality of group functioning serves as the strongest predictor of high-ability students' performance and explained much of the…

  12. Conceptualizing Concurrent Enrollment: Why High-Achieving Students Go For It

    ERIC Educational Resources Information Center

    Dare, Lynn; Nowicki, Elizabeth

    2015-01-01

    Research shows that carefully planned acceleration offers academic benefits with little social or emotional risk to high-ability learners. However, acceleration is underutilized and little is known about students' motivations to accelerate. In this study, 21 high-ability high school students in Grades 11 and 12 took part in a structured…

  13. Multiscale conformal pattern transfer

    PubMed Central

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-01-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics. PMID:27329824

  14. Multiscale conformal pattern transfer

    NASA Astrophysics Data System (ADS)

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-06-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics.

  15. Doped Si nanoparticles with conformal carbon coating and cyclized-polyacrylonitrile network as high-capacity and high-rate lithium-ion battery anodes.

    PubMed

    Xie, Ming; Piper, Daniela Molina; Tian, Miao; Clancey, Joel; George, Steven M; Lee, Se-Hee; Zhou, Yun

    2015-09-11

    Doped Si nanoparticles (SiNPs) with conformal carbon coating and cyclized-polyacrylonitrile (PAN) network displayed capacities of 3500 and 3000 mAh g(-1) at C/20 and C/10, respectively. At 1 C, the electrode preserves a specific discharge capacity of ∼1500 mAh g(-1) for at least 60 cycles without decay. Al2O3 atomic layer deposition (ALD) helps improve the initial Coulombic efficiency (CE) to 85%. The dual coating of conformal carbon and cyclized-PAN help alleviate volume change and facilitate charge transfer. Ultra-thin Al2O3 ALD layers help form a stable solid electrolyte interphase interface.

  16. Doped Si nanoparticles with conformal carbon coating and cyclized-polyacrylonitrile network as high-capacity and high-rate lithium-ion battery anodes

    NASA Astrophysics Data System (ADS)

    Xie, Ming; Molina Piper, Daniela; Tian, Miao; Clancey, Joel; George, Steven M.; Lee, Se-Hee; Zhou, Yun

    2015-09-01

    Doped Si nanoparticles (SiNPs) with conformal carbon coating and cyclized-polyacrylonitrile (PAN) network displayed capacities of 3500 and 3000 mAh g-1 at C/20 and C/10, respectively. At 1 C, the electrode preserves a specific discharge capacity of ˜1500 mAh g-1 for at least 60 cycles without decay. Al2O3 atomic layer deposition (ALD) helps improve the initial Coulombic efficiency (CE) to 85%. The dual coating of conformal carbon and cyclized-PAN help alleviate volume change and facilitate charge transfer. Ultra-thin Al2O3 ALD layers help form a stable solid electrolyte interphase interface.

  17. Addressing the Career Development Needs of High-Achieving African American High School Students: Implications for Counselors

    ERIC Educational Resources Information Center

    Parris, George P.; Owens, Delila; Johnson, Tyrone; Grbevski, Sonja; Holbert-Quince, Joanne

    2010-01-01

    African Americans face numerous obstacles in achieving their fullest developmental and career potentials in the current political, social, and economic environment. These barriers have produced, for the most part, workers who have been wage earners as opposed to being self-employed, and blue-collar workers rather than managers or proprietors…

  18. Steinberg conformal algebras

    NASA Astrophysics Data System (ADS)

    Mikhalev, A. V.; Pinchuk, I. A.

    2005-06-01

    The structure of Steinberg conformal algebras is studied; these are analogues of Steinberg groups (algebras, superalgebras).A Steinberg conformal algebra is defined as an abstract algebra by a system of generators and relations between the generators. It is proved that a Steinberg conformal algebra is the universal central extension of the corresponding conformal Lie algebra; the kernel of this extension is calculated.

  19. Electrodeposition of Gold to Conformally Fill High Aspect Ratio Nanometric Silicon Grating Trenches: A Comparison of Pulsed and Direct Current Protocols.

    PubMed

    Znati, Sami A; Chedid, Nicholas; Miao, Houxun; Chen, Lei; Bennett, Eric E; Wen, Han

    2015-10-01

    Filling high-aspect-ratio trenches with gold is a frequent requirement in the fabrication of x-ray optics as well as micro-electronic components and other fabrication processes. Conformal electrodeposition of gold in sub-micron-width silicon trenches with an aspect ratio greater than 35 over a grating area of several square centimeters is challenging and has not been described in the literature previously. A comparison of pulsed plating and constant current plating led to a gold electroplating protocol that reliably filled trenches for such structures.

  20. Highly Qualified Status Type and Student Achievement Scores, Special Education, and General Education: Is There a Connection?

    ERIC Educational Resources Information Center

    Burdett, Nicole G.

    2013-01-01

    The purpose of this research study was to examine, through statistical analyses, the impact that the 2 different types of highly qualified teachers have on student achievement reading and math scores among fourth- and fifth-grade special education and general education students for the 2010-2011 and 2011-2012 school years. The evaluation…

  1. Unpacking High and Low Efficacy Teachers' Task Analysis and Competence Assessment in Teaching Low-Achieving Students in Secondary Schools

    ERIC Educational Resources Information Center

    Wang, Li-Yi; Jen-Yi, Li; Tan, Liang-See; Tan, Irene; Lim, Xue-Fang; Wu, Bing Sheng

    2016-01-01

    This study adopted a pragmatic qualitative research design to unpack high and low efficacy teachers' task analysis and competence assessment in the context of teaching low-achieving students. Nine secondary school English and Science teachers were recruited and interviewed. Results of thematic analysis show that helping students perform well in…

  2. Effective Learning: A Case Study of the Learning Strategies Used by a Gifted High Achiever in Learning Science

    ERIC Educational Resources Information Center

    Stott, Angela; Hobden, Paul A.

    2016-01-01

    This article describes a case study of a gifted high achiever in learning science. This learner was selected on the assumption that drawing attention to the characteristics of a successful learner may improve learning effectiveness of less successful learners. The first author taught the gifted learner and collected data through participant…

  3. The Effect of Poverty on the Achievement of Urban African American Male Students Successfully Completing High School

    ERIC Educational Resources Information Center

    Welch, Amy L.

    2013-01-01

    The purpose of this study was to determine the impact of poverty on the achievement of African American male high school students attending the same large Midwest urban school district. Cumulative grade point average (GPA) at the tenth grade level were compared to the level of poverty provided through census data of African American male tenth…

  4. Retrospective Understandings: Individual-Collective Influences on High Achieving Black Students at a Predominantly White Institution of Higher Education

    ERIC Educational Resources Information Center

    Brooks, Candice Elaine

    2012-01-01

    This article discusses the findings of an exploratory qualitative study that examined the influences of individual and collective sociocultural identities on the community involvements and high academic achievement of 10 Black alumni who attended a predominantly White institution between 1985 and 2008. Syntagmatic narrative analysis and…

  5. Do Socio-Motivational Relationships Predict Achievement Motivation in Adolescents with High and Low School Self-Concepts?

    ERIC Educational Resources Information Center

    Bakadorova, Olga; Raufelder, Diana

    2016-01-01

    Considering the essential role that socio-motivational relationships at school play with respect to achievement motivation, this study examined the differences between students with a low school self-concept and students with a high school self-concept in a large sample of 7th and 8th grade students (N= 1088; M[subscript Age]= 13.7) in secondary…

  6. Practice Brief: Assessing Compensatory Strategies and Motivational Factors in High-Achieving Postsecondary Students with Attention Deficit/Hyperactivity Disorder

    ERIC Educational Resources Information Center

    Schaffer, Gary

    2013-01-01

    Research speculates that high-achieving college students with attention deficit/hyperactivity disorder (ADHD) may demonstrate a set of compensatory strategies and experience areas of difficulty and motivational factors that differ from the general ADHD populace. This Practice Brief used informal surveys with seven undergraduates with ADHD who had…

  7. The Effect of Blended Learning Model on High School Students' Biology Achievement and on Their Attitudes towards the Internet

    ERIC Educational Resources Information Center

    Yapici, I.Umit; Akbayin, Hasan

    2012-01-01

    The present study aims to determine the effect of the blended learning model on high school students' biology achievement and on their attitudes towards the Internet. Among the experimental models, the pretest-posttest control group model was used in the study. The study was carried out with 107 students (47 of whom were in the experimental group,…

  8. The Effect of Consistent Structured Reading Instruction on High and Low Literacy Achievement in Young Children Who Are Blind

    ERIC Educational Resources Information Center

    Emerson, Robert Wall; Sitar, Debbie; Erin, Jane N.; Wormsley, Diane P.; Herlich, Stephanie Leigh

    2009-01-01

    The Alphabetic Braille and Contracted Braille Study found no difference between high and low achievers in the development of literacy skills on such measures as age, etiology of visual impairment, family attitudes and behaviors regarding literacy activities, class size, and time spent with a teacher of students with visual impairments. Some…

  9. The Effective Practices and Beliefs of School Principals in High Achieving Hispanic Majority Mid-Level Schools

    ERIC Educational Resources Information Center

    Briseno, Johnny

    2010-01-01

    This qualitative phenomenological research study used narrative inquiry to investigate the effective practices and beliefs of 10 Texas principals in high achieving majority Hispanic mid-level schools. Participant interviews were analyzed using the Creswell (2007) six step method for analyzing phenomenological studies. Findings from this study…

  10. An Exploration of the Psychosocial Characteristics of High Achieving Students and Identified Gifted Students: Implications for Practice

    ERIC Educational Resources Information Center

    Ritchotte, Jennifer A.; Suhr, Diana; Alfurayh, Naif F.; Graefe, Amy K.

    2016-01-01

    High achieving students or "bright children" are often denied access to gifted services because they do not meet "gifted" criteria. Although psychosocial factors play an integral role in academic success, and can be useful in providing a clearer picture of student need, they are seldom considered in the decision to identify a…

  11. The Effect of Mathematics Curriculum Materials on the Perceived Behavior of Urban Junior High School Teachers of Low Achievers.

    ERIC Educational Resources Information Center

    Chandler, Arnold Marvin

    This study was designed to assess changes in low achievers' perceptions of classroom climate and junior high teachers' opinions of their teaching practices as a result of introducing a new set of mathematics curriculum materials. Nineteen teachers with two classes each participated. One class of each teacher used the new curriculum materials,…

  12. Relationships of Cognitive and Metacognitive Learning Strategies to Mathematics Achievement in Four High-Performing East Asian Education Systems

    ERIC Educational Resources Information Center

    Areepattamannil, Shaljan; Caleon, Imelda S.

    2013-01-01

    The authors examined the relationships of cognitive (i.e., memorization and elaboration) and metacognitive learning strategies (i.e., control strategies) to mathematics achievement among 15-year-old students in 4 high-performing East Asian education systems: Shanghai-China, Hong Kong-China, Korea, and Singapore. In all 4 East Asian education…

  13. The Perceptions of Principals and Teachers Regarding Mental Health Providers' Impact on Student Achievement in High Poverty Schools

    ERIC Educational Resources Information Center

    Perry, Teresa

    2012-01-01

    This study examined the perceptions of principals and teachers regarding mental health provider's impact on student achievement and behavior in high poverty schools using descriptive statistics, t-test, and two-way ANOVA. Respondents in this study shared similar views concerning principal and teacher satisfaction and levels of support for the…

  14. High- and Average-Achieving Students' Perceptions of Disabilities and of Students with Disabilities in Inclusive Classrooms

    ERIC Educational Resources Information Center

    Litvack, Marla S.; Ritchie, Krista C.; Shore, Bruce M.

    2011-01-01

    This study investigates attitudes toward disability held by children with disabilities and average- and high-achieving children, and the latter two groups' experiences in inclusive elementary classrooms. Attitudes Toward Disabled Persons Form-Scale (ATDP; Yuker, Block, & Young, 1966) responses did not differ. Females were more accepting. Children…

  15. Exploring Differences between Self-Regulated Learning Strategies of High and Low Achievers in Open Distance Learning

    ERIC Educational Resources Information Center

    Geduld, Bernadette

    2016-01-01

    Open distance students differ in their preparedness for higher education studies. Students who are less self-regulated risk failure and drop out in the challenging milieu of open distance learning. In this study, the differences between the application of self-regulated learning strategies by low and high achievers were explored. A multi-method…

  16. The Relationship between School Culture and Student Achievement: Perceptions of Georgia Suburban and Urban High School Administrators

    ERIC Educational Resources Information Center

    Tucker, Treva L.

    2011-01-01

    The purpose of this quantitative research study was to determine the relative impact school culture has on student achievement (specifically AYP status, dropout rates and graduation rates) in select urban and suburban Georgia high schools. To examine this relationship, the researcher reviewed data collected from the School Culture Survey (SCS)…

  17. The Effect of Computer Based Instructional Technique for the Learning of Elementary Level Mathematics among High, Average and Low Achievers

    ERIC Educational Resources Information Center

    Afzal, Muhammad Tanveer; Gondal, Bashir; Fatima, Nuzhat

    2014-01-01

    The major objective of the study was to elicit the effect of three instructional methods for teaching of mathematics on low, average and high achiever elementary school students. Three methods: traditional instructional method, computer assisted instruction (CAI) and teacher facilitated mathematics learning software were employed for the teaching…

  18. The Effects of a Professional Learning Community on Teachers and Student Achievement in a High School Serving Predominately Latino Students

    ERIC Educational Resources Information Center

    Mendez, Larry

    2013-01-01

    The research study was an evaluation of a professional learning community (PLC) and its effect on teachers and student achievement in a high school serving predominately Latino students. The study was a mixed research study that consisted of both quantitative and qualitative data. The quantitative data included school-wide and Latino student…

  19. Mathematics: Self-Efficacy, Identity, and Achievement among African American Males from the High School Longitudinal Study

    ERIC Educational Resources Information Center

    Briggs, Calvin

    2014-01-01

    The purpose of this study was to determine if a relationship existed between mathematics self-efficacy and mathematics identity to mathematics achievement among African American males from High School Longitudinal Study of 2009 (HSLS:09). Subsequently, the extent to which mathematics self-efficacy and mathematics identity accounted for low and…

  20. Powerful Pedagogies: Evaluating Effective Culturally Relevant English Instruction for High Achieving African American Males in Advanced Placement English

    ERIC Educational Resources Information Center

    Johnson, Stanley Louis, Jr.

    2011-01-01

    Helping teachers to effectively use culturally relevant instructional practices can help the educational community close the literacy gap for African American males. This study examines effective secondary English teachers and their high achieving African American male students. Using critical race and sociocultural theories as a conceptual…