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  1. Achieving true sustainability of zoo populations.

    PubMed

    Lacy, Robert C

    2013-01-01

    For the last 30 years, cooperative management of irreplaceable animal populations in zoos and aquariums has focused primarily on the goal of minimizing genetic decay within defined time frames, and large advances have been made in technologies to optimize genetic management of closed populations. However, recent analyses have shown that most zoo programs are not projected to meet their stated goals. This has been described as a lack of achieving "sustainability" of the populations, yet by definition a goal of managed decay is not a plan for sustainability. True sustainability requires management of the resource in manner that does not deplete its value for the future. Achieving such sustainability for many managed populations may require changing from managing isolated populations to managing populations that are part of a broader metapopulation, with carefully considered exchange between populations across a spectrum of ex situ to in situ. Managing zoo populations as components of comprehensive conservation strategies for the species will require research on determinants of various kinds of genetic, physiological, behavioral, and morphological variation and their roles in population viability, development of an array of management techniques and tools, training of population managers in metapopulation management and integrated conservation planning, and projections of impacts of management strategies on the viability of the captive populations and all populations that are interactively managed or affected. Such a shift in goals and methods would result in zoo population management being an ongoing part of species conservation rather than short-term or isolated from species conservation. Zoo Biol. 32:19-26, 2013. © 2012 Wiley Periodicals, Inc.

  2. True grit and genetics: predicting academic achievement from personality

    PubMed Central

    Rimfeld, Kaili; Kovas, Yulia; Dale, Philip S.; Plomin, Robert

    2015-01-01

    Grit -- perseverance and passion for long-term goals -- has been shown to be a significant predictor of academic success, even after controlling for other personality factors. Here, for the first time, we use a UK-representative sample and a genetically sensitive design to unpack the etiology of grit and its prediction of academic achievement in comparison to well-established personality traits. For 4,642 16-year-olds (2,321 twin pairs), we used the Grit-S scale (Perseverance of Effort and Consistency of Interest), along with the Big-5 personality traits, to predict scores on the General Certificate of Secondary Education (GCSE) exams, which are administered UK-wide at the end of compulsory education. Twin analyses of Grit Perseverance yielded a heritability estimate of 37% (20% for Consistency of Interest) and no evidence for shared environmental influence. Personality, primarily Conscientiousness, predicts about 6% of the variance in GCSE scores, but Grit adds little to this prediction. Moreover, multivariate twin analyses showed that roughly two-thirds of the GCSE prediction is mediated genetically. Grit Perseverance of Effort and Big-5 Conscientiousness are to a large extent the same trait both phenotypically (r=0.53) and genetically (genetic correlation = 0. 86). We conclude that the etiology of Grit is highly similar to other personality traits, not only in showing substantial genetic influence but also in showing no influence of shared environmental factors. Personality significantly predicts academic achievement, but Grit adds little phenotypically or genetically to the prediction of academic achievement beyond traditional personality factors, especially Conscientiousness. PMID:26867111

  3. Differentiation of true anophthalmia from clinical anophthalmia using neuroradiological imaging

    PubMed Central

    Celebi, Ali Riza Cenk; Sasani, Hadi

    2014-01-01

    Anophthalmia is a condition of the absence of an eye and the presence of a small eye within the orbit. It is associated with many known syndromes. Clinical findings, as well as imaging modalities and genetic analysis, are important in making the diagnosis. Imaging modalities are crucial scanning methods. Cryptophthalmos, cyclopia, synophthalmia and congenital cystic eye should be considered in differential diagnoses. We report two clinical anophthalmic siblings, emphasizing the importance of neuroradiological and orbital imaging findings in distinguishing true congenital anophthalmia from clinical anophthalmia. PMID:25071894

  4. Achieving moral, high quality, affordable medical care in America through a true free market.

    PubMed

    McKalip, David

    2016-11-01

    The basis of a just and moral economic model for health care is examined in the context of Catholic social teaching. The performance of the current model of "central economic planning" in medicine is evaluated in terms of the core principles of the social doctrine of the Catholic Church and compared to freedom-based economic models. It is clear that the best way to respect and serve human dignity, the common good, subsidiarity, and solidarity in medicine is through the establishment of a true, free-market health economy. Lay Summary : This article reviews the impact of recent healthcare reforms as well as traditional "third party payment" models for healthcare financing in America (insurance). Impact on patients and doctors are evaluated in the context of Catholic social doctrine and the Catechism. The many shortcomings and negative consequences of an economy planned centrally by government are compared to the benefits of a true free-market medical economy with empowered individuals. The analysis shows that interference in the patient-physician relationship and the centrally planned medical economy itself violates Catholic teachings, harms patients and doctors, and create morally evil outcomes and economic structures.

  5. Graduate Medical Education: Its Role in Achieving a True Medical Education Continuum.

    PubMed

    Aschenbrener, Carol A; Ast, Cori; Kirch, Darrell G

    2015-09-01

    Nearly half a century ago, Lowell T. Coggeshall recommended, through what has come to be known as the Coggeshall Report, that physician education-medical school (or undergraduate medical education [UME]), residency training (or graduate medical education [GME]), and continuing medical education (CME)-be "planned and provided as a continuum." While the dream of a true continuum remains unfulfilled, recent innovations focused on defining and assessing meaningful outcomes at last offer the anchor for the creation of a seamless, flexible, and ongoing pathway for the preparation of physicians. Recent innovations, including a widely accepted competency framework and entrustable professional activities (EPAs), provide key tools for creating a continuum. The competency framework is being leveraged in UME, GME, and CME and is serving as the foundation for the continuum. Learners and those who assess them are increasingly relying on observable behaviors (e.g., EPAs) to determine progress. The GME community in the United States and Canada has played-and continues to play-a leading role in the creation of these tools and a true medical education continuum. Despite some systemic challenges to implementation (e.g., premedical learner formation, time-in-step requirements), the GME community is already operationalizing these tools as a basis for other innovations that are improving transitions across the continuum (e.g., competency-based progression of residents). The medical education community's greatest responsibility in the years ahead will be to build on these efforts in GME-joining together to learn from one another and develop a continuum that serves the public and the profession.

  6. Achieving quality assurance through clinical audit.

    PubMed

    Patel, Seraphim

    2010-06-01

    Audit is a crucial component of improvements to the quality of patient care. Clinical audits are undertaken to help ensure that patients can be given safe, reliable and dignified care, and to encourage them to self-direct their recovery. Such audits are undertaken also to help reduce lengths of patient stay in hospital, readmission rates and delays in discharge. This article describes the stages of clinical audit and the support required to achieve organisational core values.

  7. Clinical trials in Russia: achieving excellence

    NASA Astrophysics Data System (ADS)

    Reznik, Robert S.; Ichim, Thomas E.; Petrov, Vladimir; Reznik, Boris N.

    2005-06-01

    The Russian population offers a unique opportunity for conducting clinical trials in general, and specifically in the area of Medical Devices. Although the regulatory framework for approval of clinical trials and eventual marketing registration is based on an American-style format, details of operating in the Russian framework are very different. Understanding and leveraging the unique characteristics of the Russian system on the patient side, the investigator side, and the regulatory side is important in extracting optimum value out of clinical trials in Russia. Having performed Medical Device research and clinical trials in Russia, the authors overview the present system and describe various strategies for working in this growing but still under-utilized clinical trials arena.

  8. Variability in Clinical Integration Achieved by Athletic Training Students across Different Clinical Sport Assignments

    ERIC Educational Resources Information Center

    Dodge, Thomas M.; Mazerolle, Stephanie M.; Bowman, Thomas G.

    2015-01-01

    Context: Clinical integration impacts athletic training students' (ATSs) motivation and persistence. Research has yet to elucidate the manner in which different clinical placements can influence clinical integration. Objective: To examine differences in the levels of clinical integration achieved by ATSs across various clinical sport assignments.…

  9. Clinical, cytogenetical, histological, immunological and hormonal studies in a case of true hermaphroditism.

    PubMed

    Roy, C; Roger, M; Boccon-Gibod, L; Fellous, M; Bonno, R; Pasqualini, J; Harpey, J P

    1980-05-01

    A true hermaphrodite with ambiguous genitalia and 46XX karyotype was studied from 18 months of age to 17 years. At 13 years, he developed an ambiguous puberty, with marked bilateral gynaecomastia and public hair score three. A relatively high testosterone level (21 nmol/l), not increased by hCG stimulation, was associated with a high LH level (6 UI/l). In the venous blood of the right ovotestis, the steroid concentrations were in the adult male range, especially testosterone (1400 nmol/l). After removal of the right gonad, large fluctuations of oestradiol levels were observed (150-810 pmol/l). The testosterone secretion of the left ovotestis was low, concentrations begin 4.2 and 130 nmol/l in peripheral and gonadal blood respectively at 16 years. A significant LH surge was induced by oral ethinyl-oestradiol before removal of the left gonad. The 5 alpha-reductase activity was normal in pubic skin. In the left gonad the concentrations of cytosol receptors for testosterone and 5 alpha-dihydrotestosterone (DHT) were significant: 14.5 and 65.5 fmol/mg protein respectively. However the plasma DHT level was not increased by hCG. Finally, the presence of H-Y antigen was demonstrated on lymphocytes. This accords with the presence of testicular tissue in an XX subject, and with significant testosterone production. The high testosterone production did not prevent the appearance of a positive oestrogen-LH feedback. The relative peripheral insensitivity to testosterone, is, in some ways, inconsistent with the presence of receptors for androgens.

  10. Improving International Research with Clinical Specimens: 5 Achievable Objectives

    PubMed Central

    LaBaer, Joshua

    2012-01-01

    Our increased interest in translational research has created a large demand for blood, tissue and other clinical samples, which find use in a broad variety of research including genomics, proteomics, and metabolomics. Hundreds of millions of dollars have been invested internationally on the collection, storage and distribution of samples. Nevertheless, many researchers complain in frustration about their inability to obtain relevant and/or useful samples for their research. Lack of access to samples, poor condition of samples, and unavailability of appropriate control samples have slowed our progress in the study of diseases and biomarkers. In this editorial, I focus on five major challenges that thwart clinical sample use for translational research and propose near term objectives to address them. They include: (1) defining our biobanking needs; (2) increasing the use of and access to standard operating procedures; (3) mapping inter-observer differences for use in normalizing diagnoses; (4) identifying natural internal protein controls; and (5) redefining the clinical sample paradigm by building partnerships with the public. In each case, I believe that we have the tools at hand required to achieve the objective within 5 years. Potential paths to achieve these objectives are explored. However we solve these problems, the future of proteomics depends on access to high quality clinical samples, collected under standardized conditions, accurately annotated and shared under conditions that promote the research we need to do. PMID:22998582

  11. Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine

    SciTech Connect

    Annesley, Thomas M.; Cooks, Robert G.; Herold, David A.; Hoofnagle, Andrew N.

    2016-01-04

    Each year the journal Clinical Chemistry publishes a January special issue on a topic that is relevant to the laboratory medicine community. In January 2016 the topic is mass spectrometry, and the issue is entitled “Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”. One popular feature in our issues is a Q&A on a topic, clearly in this case mass spectrometry. The journal is assembling a panel of 5-6 experts from various areas of mass spectrometry ranging from instrument manufacturing to practicing clinical chemists. Dick Smith is one of the scientist requested to participate in this special issue Q&A on Mass Spectrometry. The Q&A Transcript is attached

  12. Different clinical electrodes achieve similar electrical nerve conduction block

    NASA Astrophysics Data System (ADS)

    Boger, Adam; Bhadra, Narendra; Gustafson, Kenneth J.

    2013-10-01

    Objective. We aim to evaluate the suitability of four electrodes previously used in clinical experiments for peripheral nerve electrical block applications. Approach. We evaluated peripheral nerve electrical block using three such clinical nerve cuff electrodes (the Huntington helix, the Case self-sizing Spiral and the flat interface nerve electrode) and one clinical intramuscular electrode (the Memberg electrode) in five cats. Amplitude thresholds for the block using 12 or 25 kHz voltage-controlled stimulation, onset response, and stimulation thresholds before and after block testing were determined. Main results. Complete nerve block was achieved reliably and the onset response to blocking stimulation was similar for all electrodes. Amplitude thresholds for the block were lowest for the Case Spiral electrode (4 ± 1 Vpp) and lower for the nerve cuff electrodes (7 ± 3 Vpp) than for the intramuscular electrode (26 ± 10 Vpp). A minor elevation in stimulation threshold and reduction in stimulus-evoked urethral pressure was observed during testing, but the effect was temporary and did not vary between electrodes. Significance. Multiple clinical electrodes appear suitable for neuroprostheses using peripheral nerve electrical block. The freedom to choose electrodes based on secondary criteria such as ease of implantation or cost should ease translation of electrical nerve block to clinical practice.

  13. Achieving Core Indicators for HIV Clinical Care Among New Patients at an Urban HIV Clinic.

    PubMed

    Greer, Gillian A; Tamhane, Ashutosh; Malhotra, Rakhi; Burkholder, Greer A; Mugavero, Michael J; Raper, James L; Zinski, Anne

    2015-09-01

    Following the release of the 2010 National HIV/AIDS Strategy for the United States, the Institute of Medicine (IOM) issued core clinical indicators for measuring health outcomes in HIV-positive persons. As early retention in HIV primary care is associated with improved long-term health outcomes, we employed IOM indicators as a guide to examine a cohort of persons initiating HIV outpatient medical care at a university-affiliated HIV clinic in the Southern United States (January 2007-July 2012). Using indicators for visit attendance, CD4 and viral load laboratory testing frequency, and antiretroviral therapy initiation, we evaluated factors associated with achieving IOM core indicators among care- and treatment-naïve patients during the first year of HIV care. Of 448 patients (mean age = 35 years, 35.7% white, 79.0% male, 58.4% education beyond high school, 35.9% monthly income > $1,000 US, 47.3% uninsured), 84.6% achieved at least four of five IOM indicators. In multivariable analyses, persons with monthly income > $1,000 (ORadj. = 3.71; 95% CI: 1.68-8.19; p = 0.001) and depressive symptoms (ORadj. = 2.13; 95% CI: 1.02-4.45; p = 0.04) were significantly more likely to achieve at least four of the five core indicators, while patients with anxiety symptoms were significantly less likely to achieve these indicators (ORadj. = 0.50; 95% CI: 0.26-0.97; p = 0.04). Age, sex, race, education, insurance status, transportation barriers, alcohol use, and HIV status disclosure to family were not associated with achieving core indicators. Evaluating and addressing financial barriers and anxiety symptoms during the first year of HIV outpatient care may improve individual health outcomes and subsequent achievement of the National HIV/AIDS Strategy.

  14. Achieving the World Health Organization's vision for clinical pharmacology.

    PubMed

    Martin, Jennifer H; Henry, David; Gray, Jean; Day, Richard; Bochner, Felix; Ferro, Albert; Pirmohamed, Munir; Mörike, Klaus; Schwab, Matthias

    2016-02-01

    Clinical pharmacology is a medical specialty whose practitioners teach, undertake research, frame policy, give information and advice about the actions and proper uses of medicines in humans and implement that knowledge in clinical practice. It involves a combination of several activities: drug discovery and development, training safe prescribers, providing objective and evidence-based therapeutic information to ethics, regulatory and pricing bodies, supporting patient care in an increasingly subspecialized arena where co-morbidities, polypharmacy, altered pharmacokinetics and drug interactions are common and developing and contributing to medicines policies for Governments. Clinical pharmacologists must advocate drug quality and they must also advocate for sustainability of the Discipline. However for this they need appropriate clinical service and training support. This Commentary discusses strategies to ensure the Discipline is supported by teaching, training and policy organizations, to communicate the full benefits of clinical pharmacology services, put a monetary value on clinical pharmacology services and to grow the clinical pharmacology workforce to support a growing clinical, academic and regulatory need.

  15. Achieving the World Health Organization's vision for clinical pharmacology

    PubMed Central

    Henry, David; Gray, Jean; Day, Richard; Bochner, Felix; Ferro, Albert; Pirmohamed, Munir; Mörike, Klaus; Schwab, Matthias

    2015-01-01

    Clinical pharmacology is a medical specialty whose practitioners teach, undertake research, frame policy, give information and advice about the actions and proper uses of medicines in humans and implement that knowledge in clinical practice. It involves a combination of several activities: drug discovery and development, training safe prescribers, providing objective and evidence‐based therapeutic information to ethics, regulatory and pricing bodies, supporting patient care in an increasingly subspecialized arena where co‐morbidities, polypharmacy, altered pharmacokinetics and drug interactions are common and developing and contributing to medicines policies for Governments. Clinical pharmacologists must advocate drug quality and they must also advocate for sustainability of the Discipline. However for this they need appropriate clinical service and training support. This Commentary discusses strategies to ensure the Discipline is supported by teaching, training and policy organizations, to communicate the full benefits of clinical pharmacology services, put a monetary value on clinical pharmacology services and to grow the clinical pharmacology workforce to support a growing clinical, academic and regulatory need. PMID:26466826

  16. Using nursing clinical decision support systems to achieve meaningful use.

    PubMed

    Harrison, Roberta L; Lyerla, Frank

    2012-07-01

    The Health Information Technology and Clinical Health Act (one component of the American Recovery and Reinvestment Act) is responsible for providing incentive payments to hospitals and eligible providers in an effort to support the adoption of electronic health records. Future penalties are planned for electronic health record noncompliance. In order to receive incentives and avoid penalties, hospitals and eligible providers must demonstrate "meaningful use" of their electronic health records. One of the meaningful-use objectives established by the Centers for Medicare & Medicaid Services involves the use of a clinical decision support rule that addresses a hospital-defined, high-priority condition. This article describes the Plan-Do-Study-Act process for creating and implementing a nursing clinical decision support system designed to improve guideline adherence for hypoglycemia management. This project identifies hypoglycemia management as the high-priority area. However, other facilities with different high-priority conditions may find the process presented in this article useful for implementing additional clinical decision support rules geared toward improving outcomes and meeting federal mandates.

  17. Expertise, Ethics Expertise, and Clinical Ethics Consultation: Achieving Terminological Clarity.

    PubMed

    Iltis, Ana S; Sheehan, Mark

    2016-08-01

    The language of ethics expertise has become particularly important in bioethics in light of efforts to establish the value of the clinical ethics consultation (CEC), to specify who is qualified to function as a clinical ethics consultant, and to characterize how one should evaluate whether or not a person is so qualified. Supporters and skeptics about the possibility of ethics expertise use the language of ethics expertise in ways that reflect competing views about what ethics expertise entails. We argue for clarity in understanding the nature of expertise and ethics expertise. To be an ethics expert, we argue, is to be an expert in knowing what ought to be done. Any attempt to articulate expertise with respect to knowing what ought to be done must include an account of ethics that specifies the nature of moral truth and the means by which we access this truth or a theoretical account of ethics such that expertise in another domain is linked to knowing or being better at judging what ought to be done and the standards by which this "knowing" or "being better at judging" is determined. We conclude with a discussion of the implications of our analysis for the literature on ethics expertise in CEC. We do think that there are clear domains in which a clinical ethics consultant might be expert but we are skeptical about the possibility that this includes ethics expertise. Clinical ethics consultants should not be referred to as ethics experts.

  18. Clinical Application of Preconditioning and Postconditioning to Achieve Neuroprotection

    PubMed Central

    Dezfulian, Cameron; Garrett, Matthew; Gonzalez, Nestor R.

    2012-01-01

    Ischemic conditioning is a form of endogenous protection induced by transient, subcritical ischemia in a tissue. Organs with high sensitivity to ischemia, such as the heart, the brain, and spinal cord represent the most critical and potentially promising targets for potential therapeutic applications of ischemic conditioning. Numerous preclinical investigations have systematically studied the molecular pathways and potential benefits of both pre- and post-conditioning with promising results. The purpose of this review is to summarize the present knowledge on cerebral pre-and post-conditioning, with an emphasis in the clinical application of these forms of neuroprotection. Methods A systematic Medline search for the terms preconditioning and postconditioning was performed. Publications related to the nervous system and to human applications were selected and analyzed. Findings Pre-and post-conditioning appear to provide similar levels of neuroprotection. The preconditioning window of benefit can be subdivided into early and late effects, depending on whether the effect appears immediately after the sublethal stress or with a delay of days. In general early effects have been associated post-translational modification of critical proteins (membrane receptors, mitochondrial respiratory chain) while late effects are the result of gene up-or down-regulation. Transient ischemic attacks appear to represent a form of clinically relevant preconditioning by inducing ischemic tolerance in the brain and reducing the severity of subsequent strokes. Remote forms of ischemic pre- and post-conditioning have been more commonly used in clinical studies, as the remote application reduces the risk of injuring the target tissue for which protection is pursued. Limb transient ischemia is the preferred method of induction of remote conditioning with evidence supporting its safety. Clinical studies in a variety of populations at risk of central nervous damage including carotid disease

  19. Feedback and assessment for clinical placements: achieving the right balance

    PubMed Central

    Burgess, Annette; Mellis, Craig

    2015-01-01

    During clinical placements, the provision of feedback forms an integral part of the learning process and enriches students’ learning experiences. The purpose of feedback is to improve the learner’s knowledge, skills, or behavior. Receipt of accurate feedback can help to narrow the gap between actual and desired performance. Effective and regular feedback has the potential to reinforce good practice and motivate the learner toward the desired outcome. Despite the obvious role of feedback in effective teaching and learning, a common complaint from students is that they do not receive adequate feedback. Unfortunately, skills in giving and receiving feedback are rarely taught to students or clinicians. This study aims to provide an understanding of the role of feedback within the learning process, consider consequences of inadequate or poorly given feedback, consider the barriers to the feedback process, provide practical guidelines for providing feedback, and consider the need for student and faculty development in feedback skills. PMID:26056511

  20. True deficiency of antioxidant vitamins E and A in dialysis patients. Relationship with clinical patterns of atherosclerosis.

    PubMed

    Aguilera, Abelardo; Bajo, M Auxiliadora; del Peso, Gloria; Diez, Juan J; Codoceo, Rosa; Rebollo, Francisco; Mariano, Mario; Selgas, Rafael

    2002-01-01

    Atherosclerosis is an important cause of morbidity and mortality in peritoneal dialysis (PD) patients. Oxidative stress plays a role in the pathogenesis of uremic atherosclerosis. Although antioxidant substances (vitamins A and E) are elevated in the plasma of dialysis patients, intracellular and clinical signs of hypovitaminosis are frequently found. Recently, the importance of vitamin/carrier complexes as a marker of vitamin bioavailability has been demonstrated. In the present study, we analyzed vitamin A and E bioavailability, measured as vitamin/carrier complexes, and the relationship of those measurements with clinical atherosclerosis status in PD patients. We studied 45 patients (15 men, 30 women), who were divided into four groups according to clinical atherosclerotic score (CAS). Five cases were scored as CAS grade 1 (low CAS); 9 as CAS-2; 18 as CAS-3; and 13 as CAS-4. Vitamins A and E and their carriers [prealbumin and retinol binding protein (vitamin A), and cholesterol and triglycerides (vitamin E)] were determined. Plasma levels of vitamin A were low in 5 patients, normal in 7 patients, and high in 33 patients. By correcting the values for the carrier levels, we created three groups: 24 patients showed low vitamin A/carrier complex (5 from the low plasma vitamin A group, 6 from the normal-value group, and 13 from the high-value group); 11 patients were in the group with normal vitamin A/carrier (1 from the normal plasma vitamin A group, and 10 from the high-value group); and 10 patients were in the group with high vitamin A/carrier. The vitamin A/carrier complex showed a statistically significant, negative linear correlation with CAS and with serum iron. Low vitamin E plasma levels were found in 1 patient, normal levels in 28 patients, and high levels in 16 patients. When those values were corrected using the carrier values, three groups were also created. The group with low vitamin E/carrier complex contained 24 patients (1 from the low-value group

  1. The clinical achievement portfolio: an outcomes-based assessment project in nursing education.

    PubMed

    Tracy, S M; Marino, G J; Richo, K M; Daly, E M

    2000-01-01

    Dynamic healthcare market forces impel educators to search for innovative methods of academic assessment to measure learning outcomes. The clinical achievement portfolio is a creative and systematic tool for documenting continuous improvement of student clinical learning. The authors describe the use of the portfolio as a pilot project aimed at introducing reflective thinking and measuring clinical learning in undergraduate nursing education. Potential benefits of the clinical portfolio and implications for future research are proposed.

  2. A True Metasurface Antenna

    PubMed Central

    Badawe, Mohamed El; Almoneef, Thamer S.; Ramahi, Omar M.

    2016-01-01

    We present a true metasurface antenna based on electrically-small resonators. The resonators are placed on a flat surface and connected to one feed point using corporate feed. Unlike conventional array antennas where the distance between adjacent antennas is half wavelength to reduce mutual coupling between adjacent antennas, here the distance between the radiating elements is electrically very small to affect good impedance matching of each resonator to its feed. A metasurface antenna measuring 1.2λ × 1.2λ and designed to operate at 3 GHz achieved a gain of 12 dBi. A prototype was fabricated and tested showing good agreement between numerical simulations and experimental results. Through numerical simulation, we show that the metasurface antenna has the ability to provide beam steering by phasing all the resonators appropriately. PMID:26759177

  3. Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

    PubMed Central

    2011-01-01

    The Institute of Medicine has targeted patient-centeredness as an important area of quality improvement. A major dimension of patient-centeredness is respect for patient's values, preferences, and expressed needs. Yet specific approaches to gaining this understanding and translating it to quality care in the clinical setting are lacking. From a patient perspective quality is not a simple concept but is best understood in terms of five dimensions: technical outcomes; decision-making efficiency; amenities and convenience; information and emotional support; and overall patient satisfaction. Failure to consider quality from this five-pronged perspective results in a focus on medical outcomes, without considering the processes central to quality from the patient's perspective and vital to achieving good outcomes. In this paper, we argue for applying the concept of fair process in clinical settings. Fair process involves using a collaborative approach to exploring diagnostic issues and treatments with patients, explaining the rationale for decisions, setting expectations about roles and responsibilities, and implementing a core plan and ongoing evaluation. Fair process opens the door to bringing patient expertise into the clinical setting and the work of developing health care goals and strategies. This paper provides a step by step illustration of an innovative visual approach, called photovoice or photo-elicitation, to achieve fair process in clinical work with acquired brain injury survivors and others living with chronic health conditions. Applying this visual tool and methodology in the clinical setting will enhance patient-provider communication; engage patients as partners in identifying challenges, strengths, goals, and strategies; and support evaluation of progress over time. Asking patients to bring visuals of their lives into the clinical interaction can help to illuminate gaps in clinical knowledge, forge better therapeutic relationships with patients living

  4. Using visual and narrative methods to achieve fair process in clinical care.

    PubMed

    Lorenz, Laura S; Chilingerian, Jon A

    2011-02-16

    The Institute of Medicine has targeted patient-centeredness as an important area of quality improvement. A major dimension of patient-centeredness is respect for patient's values, preferences, and expressed needs. Yet specific approaches to gaining this understanding and translating it to quality care in the clinical setting are lacking. From a patient perspective quality is not a simple concept but is best understood in terms of five dimensions: technical outcomes; decision-making efficiency; amenities and convenience; information and emotional support; and overall patient satisfaction. Failure to consider quality from this five-pronged perspective results in a focus on medical outcomes, without considering the processes central to quality from the patient's perspective and vital to achieving good outcomes. In this paper, we argue for applying the concept of fair process in clinical settings. Fair process involves using a collaborative approach to exploring diagnostic issues and treatments with patients, explaining the rationale for decisions, setting expectations about roles and responsibilities, and implementing a core plan and ongoing evaluation. Fair process opens the door to bringing patient expertise into the clinical setting and the work of developing health care goals and strategies. This paper provides a step by step illustration of an innovative visual approach, called photovoice or photo-elicitation, to achieve fair process in clinical work with acquired brain injury survivors and others living with chronic health conditions. Applying this visual tool and methodology in the clinical setting will enhance patient-provider communication; engage patients as partners in identifying challenges, strengths, goals, and strategies; and support evaluation of progress over time. Asking patients to bring visuals of their lives into the clinical interaction can help to illuminate gaps in clinical knowledge, forge better therapeutic relationships with patients living

  5. Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure.

    PubMed

    Packer, Milton; Holcomb, Richard; Abraham, William T; Anker, Stefan; Dickstein, Kenneth; Filippatos, Gerasimos; Krum, Henry; Maggioni, Aldo P; McMurray, John J V; Mebazaa, Alexandre; O'Connor, Christopher; Peacock, Frank; Ponikowski, Piotr; Ruschitzka, Frank; van Veldhuisen, Dirk J; Holzmeister, Johannes

    2016-11-13

    The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients following their initial clinical presentation (within 12 h), and entry blood pressure criteria and thresholds for the adjustment of drug infusion rates, which aim to minimize the risk of hypotension. The trial has two primary endpoints: (i) cardiovascular mortality during long-term follow-up; and (ii) the clinical course of patients during their index hospitalization. Cardiovascular mortality is evaluated in this event-driven trial by following all randomized patients for the occurrence of death until the end of the entire study without truncation at an arbitrarily determined early time point. The clinical course during the index hospitalization is evaluated using the hierarchical clinical composite endpoint, which combines information regarding changes in symptoms and the occurrence of in-hospital worsening heart failure events and death into a single ranked metric that captures interval clinical events and minimizes the likelihood of missing data and confounding due to intensification of background therapy. The design of the TRUE-AHF trial capitalizes on lessons learned from earlier trials and aims to evaluate definitively the potential benefit of ularitide in patients with acute heart failure.

  6. Achieving consensus for clinical trials: the REiNS International Collaboration.

    PubMed

    Plotkin, Scott R; Blakeley, Jaishri O; Dombi, Eva; Fisher, Michael J; Hanemann, C Oliver; Walsh, Karin S; Wolters, Pamela L; Widemann, Brigitte C

    2013-11-19

    The neurofibromatoses (NF)--including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis--are related tumor-suppressor syndromes characterized by a predisposition to multiple tumor types and other disease manifestations, which often result in functional disability, reduced quality of life, pain, and, in some cases, malignancy. With increasing knowledge of the biology and pathogenesis of NF, clinical trials with targeted agents directed at NF tumors have become available. Most clinical trials for patients with NF have used designs and endpoints similar to oncology trials. However, differences in the disease manifestations and natural history of NF (compared to cancers) require the development of new designs and endpoints to perform meaningful NF clinical trials. The Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration was established in 2011 at the Children's Tumor Foundation meeting to achieve consensus within the NF community about the design of future clinical trials, with a specific emphasis on endpoints. The REiNS Collaboration includes 7 working groups that focus on imaging of tumor response; functional, visual, patient-reported, and neurocognitive outcomes; whole-body MRI; and disease biomarkers. This supplement includes the first series of recommendations by the REiNS Collaboration. The hope is that these recommendations will be used by members of the group and by researchers outside of the REiNS International Collaboration to standardize the measurement of outcomes and thus improve clinical trials for patients with NF. Ultimately, we plan to engage industry partners and national regulatory agencies in this process to facilitate the approval of drugs for patients with NF.

  7. True Colors of Mars

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image taken on Mars by the panoramic camera on the Mars Exploration Rover Spirit shows the rover's color calibration target, also known as the MarsDial. The target's mirror and the shadows cast on it by the Sun help scientists determine the degree to which dusty martian skies alter the panoramic camera's perception of color. By adjusting for this effect, Mars can be seen in all its true colors.

  8. Invited Commentary: The Tao of Clinical Cohort Analysis-When the Transitions That Can Be Spoken of Are Not the True Transitions.

    PubMed

    Mooney, Stephen J

    2017-03-10

    Patterns in risk-related behaviors identified using clinically deployed surveys may hold value for public health surveillance. However, because such surveys assess subjects only when subjects choose to visit clinics, clinical data are subject to variability in observation patterns that is not present in conventional longitudinal data sets in which research teams contact subjects at regular intervals. In this issue of the Journal, Wilkinson et al. (Am J Epidemiol. 2017;000(00):000-000) describe how they applied a latent transition analysis technique to surveillance data collected during clinic visits. In this commentary I discusses the selection bias that may arise in longitudinal analysis of clinical data due to subject-specific observation patterns, with particular focus on issues that may arise due to classifying successive clinical visits as waves. I suggest that quantitative bias analysis and inverse probability weighting may be useful techniques with which to assess and control bias in future latent transition analyses of clinical data.

  9. A Pharmacist-Staffed, Virtual Gout Management Clinic for Achieving Target Serum Uric Acid Levels: A Randomized Clinical Trial

    PubMed Central

    Goldfien, Robert; Pressman, Alice; Jacobson, Alice; Ng, Michele; Avins, Andrew

    2016-01-01

    Context: Relatively few patients with gout receive appropriate treatment. Objective: To determine whether a pharmacist-staffed gout management program is more effective than usual care in achieving target serum uric acid (sUA) levels in gout patients. Design: A parallel-group, randomized controlled trial of a pharmacist-staffed, telephone-based program for managing hyperuricemia vs usual care. Trial duration was 26 weeks. Main Outcome Measures: Primary outcome measure was achieving sUA levels at or below 6 mg/dL at the 26-week visit. Secondary outcome was mean change in sUA levels in the control and intervention groups. Participants were adults with recurrent gout and sUA levels above 6.0 mg/dL. Participants were randomly assigned to management by a clinical pharmacist following protocol or to monitoring of sUA levels but management of their gout by their usual treating physician. Results: Of 102 patients who met eligibility criteria, 77 subjects obtained a baseline sUA measurement and were entered into the trial. Among 37 participants in the intervention group, 13 (35%) had sUA levels at or below 6.0 mg/dL at 26 weeks, compared with 5 (13%) of 40 participants in the control group (risk ratio = 2.8, 95% confidence interval [CI] = 1.1 to 7.1, p = 0.03). The mean change in sUA levels among controls was +0.1 mg/dL compared with −1.5 mg/dL in the intervention group (sUA difference = −1.6, 95% CI = −0.9 to −2.4, p < 0.001). Conclusions: A structured pharmacist-staffed program was more effective than usual care for achieving target sUA levels. These results suggest a structured program could greatly improve gout management. PMID:27352414

  10. Learners’ perspective: where and when pre-residency trainees learn more to achieve their core clinical competencies

    PubMed Central

    2016-01-01

    Purpose While it is known that effective clinical education requires active involvement of its participants, regular feedback, communication skills and interprofessional training, limited studies have been conducted in Korea that demonstrate how pre-residency trainees acquire their core clinical skills. This is a cross-sectional study of interns and students across a third-tier university hospital in Korea to examine where and when they acquire core clinical skills. Methods A total of 74 students and 91 interns were asked to participate in a closed-ended questionnaire, and 50 participants (20 students and 30 interns) were involved in semistructured individual interviews. The questionnaire was based on the Accreditation Council for Graduate Medical Education core competencies. Results The majority of core clinical skills were acquired during their rotations in emergency medicine, general surgery, and cardiothoracic surgery. The semistructured interviews revealed that these departments required their trainees to be highly involved and analytical, and participate in clinical discourse. Conclusion The common factor among the three departments is an environment in which trainees are highly involved in clinical duties, and are expected to make first-contact patient encounters, participate in clinical discourse, interpret investigative results and arrive at their own conclusions. Work-based learning appear to be key to the trends observed, and further study is warranted to determine whether these findings are indicative of true acquisition of clinical competence. PMID:27907982

  11. Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn's disease

    PubMed Central

    Ran, Zhi Hua; Gao, Xiang; Chen, Minhu; Zhong, Jie; Sheng, Jian-Qiu; Kamm, Michael A; Travis, Simon; Wallace, Kori; Mostafa, Nael M; Shapiro, Marisa; Li, Yao; Thakkar, Roopal B; Robinson, Anne M

    2016-01-01

    Background/Aims This was a Phase 2 study (NCT02015793) to evaluate the pharmacokinetics, safety, and efficacy of adalimumab in Chinese patients with Crohn's disease (CD). Methods Thirty, adult Chinese patients with CD (CD Activity Index [CDAI] 220–450; high-sensitivity [hs]-C-reactive protein [CRP] ≥3 mg/L) received double-blind adalimumab 160/80 mg or 80/40 mg at weeks 0/2, followed by 40 mg at weeks 4 and 6. An open-label extension period occurred from weeks 8–26; patients received 40 mg adalimumab every other week. Serum adalimumab concentration and change from baseline in fecal calprotectin (FC) were measured during the double-blind period. Clinical remission (CDAI <150), response (decrease in CDAI ≥70 points from baseline), and change from baseline in hs-CRP were assessed through week 26. Nonresponder imputation was used for missing categorical data and last observation carried forward for missing hs-CRP/FC values. No formal hypothesis was tested. Adverse events were monitored. Results Mean adalimumab serum concentrations during the induction phase were 13.9–18.1 µg/mL (160/80 mg group) and 7.5−9.5 µg/mL (80/40 mg group). During the double-blind period, higher remission/response rates and greater reductions from baseline in hs-CRP and FC were observed with adalimumab 160/80 mg compared to that with 80/40 mg. Adverse event rates were similar among all treatment groups. Conclusions Adalimumab serum concentrations in Chinese patients with CD were comparable to those observed previously in Western and Japanese patients. Clinically meaningful remission rates and improvement in inflammatory markers were achieved with both dosing regimens; changes occurred rapidly with adalimumab 160/80 mg induction therapy. No new safety signals were reported. PMID:27175116

  12. True Colors Shining Through

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image mosaic illustrates how scientists use the color calibration targets (upper left) located on both Mars Exploration Rovers to fine-tune the rovers' sense of color. In the center, spectra, or light signatures, acquired in the laboratory of the colored chips on the targets are shown as lines. Actual data from Mars Exploration Rover Spirit's panoramic camera is mapped on top of these lines as dots. The plot demonstrates that the observed colors of Mars match the colors of the chips, and thus approximate the red planet's true colors. This finding is further corroborated by the picture taken on Mars of the calibration target, which shows the colored chips as they would appear on Earth.

  13. Clinical Outcomes according to the Achievement of Target Low Density Lipoprotein-Cholesterol in Patients with Acute Myocardial Infarction

    PubMed Central

    Ahn, Taehoon; Lee, Kyounghoon; Kang, Woong Chol; Han, Seung Hwan; Ahn, Youngkeun; Jeong, Myung Ho

    2017-01-01

    Background and Objectives The clinical outcome of patient with an acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI), with or without achievement of target low density lipoprotein-cholesterol (LDL-C), has little known information. This study investigated if target LDL-C level (below 70 mg/dL) achievements in patients with AMI showed better clinical outcomes or not. Subjects and Methods Between May 2008 and September 2012, this study enrolled 13473 AMI patients in a large-scale, prospective, multicenter Korean Myocardial Infarction (KorMI) registry. 12720 patients survived and 6746 patients completed a 1-year clinical follow up. Among them 3315 patients received serial lipid profile follow-ups. Propensity score matching was applied to adjust for differences in clinical baseline and angiographic characteristics, producing a total of 1292 patients (646 target LDL-C achievers vs. 646 non-achievers). The primary end point was the composite of a 1-year major adverse cardiac event (MACE) including cardiac death, recurrent myocardial infarction (MI), target lesion revascularization (TLR) and coronary artery bypass grafting. Results After propensity score matching, baseline clinical and angiographic characteristics were similar between the two groups. Clinical outcomes of the propensity score matched patients who showed no significant differences in cardiac death (0.5% vs. 0.5%, p=1.000), recurrent MI (1.1% vs. 0.8%, p=0.562), TLR (5.0% vs. 4.5%, p=0.649), MACEs (6.5% vs. 5.9%, p=0.644) and stent thrombosis (2.5% vs. 1.9%, p=0.560). Conclusion In this propensity-matched comparison, AMI patients undergoing PCI with a target LDL-C (below 70 mg/dL) achievement did not show better clinical outcomes. PMID:28154588

  14. True vasculitis in lupus nephritis.

    PubMed

    Abdellatif, A A; Waris, S; Lakhani, A; Kadikoy, H; Haque, W; Truong, L D

    2010-08-01

    Vascular lesions are encountered frequently in renal biopsy specimens of patients with systemic lupus erythematosus (SLE) and can present in a variety of morphologic forms. True renal lupus vasculitis (TRLV) is one of the rare vascular lesions associated with lupus nephritis that has been infrequently reported in the medical literature. The primary focus on glomerular pathology and collective classification of the vascular lesions under lupus vasculopathy is one of the reasons why this form of inflammatory vasculitis has been under-recognized as a separate disease entity. Here we have comprehensively reviewed the literature on renal vascular involvement in SLE for a better understanding of the epidemiology, morphologic features, pathogenesis, clinical course and treatment of TRLV. It can be morphologically differentiated from other forms of renal vascular lesions in lupus nephritis, i.e. arteriosclerosis, uncomplicated vascular immune deposits, non-inflammatory necrotizing vasculopathy, and thrombotic microangiopathy. Despite close similarities with antineutrophil cytoplasmic autoantibody associated vasculitis (AASV), there are certain morphological differences that warrant a thorough investigation of the possible pauci-immune mechanism of pathogenesis. The vasculitis follows a severe clinical course in general with rapid progression to renal failure, although favorable outcomes have been reported in certain cases. The standard use of steroids and cytotoxic drugs has yielded variable results in the treatment of TRLV. Current treatment modalities being used in lupus nephritis and AASV have been compared in this article with focus on drugs acting on the inflammatory cells implicated in TRLV pathogenesis.

  15. A hybrid approach to achieving both marginal and conditional balances for stratification variables in sequential clinical trials.

    PubMed

    Lin, Yunzhi; Su, Zheng

    2013-01-01

    Various methods exist in the literature for achieving marginal balance for baseline stratification variables in sequential clinical trials. One major limitation with balancing on the margins of the stratification variables is that there is an efficiency loss when the primary analysis is stratified. To preserve the efficiency of a stratified analysis one recently proposed approach balances on the crossing of the stratification variables included in the analysis, which achieves conditional balance for the variables. A hybrid approach to achieving both marginal and conditional balances in sequential clinical trials is proposed, which is applicable to both continuous and categorical stratification variables. Numerical results based on extensive simulation studies and a real dataset show that the proposed approach outperforms the existing ones and is particularly useful when both additive and stratified models are planned for a trial.

  16. Scope-of-practice laws for nurse practitioners limit cost savings that can be achieved in retail clinics.

    PubMed

    Spetz, Joanne; Parente, Stephen T; Town, Robert J; Bazarko, Dawn

    2013-11-01

    Retail clinics have the potential to reduce health spending by offering convenient, low-cost access to basic health care services. Retail clinics are often staffed by nurse practitioners (NPs), whose services are regulated by state scope-of-practice regulations. By limiting NPs' work scope, restrictive regulations could affect possible cost savings. Using multistate insurance claims data from 2004-07, a period in which many retail clinics opened, we analyzed whether the cost per episode associated with the use of retail clinics was lower in states where NPs are allowed to practice independently and to prescribe independently. We also examined whether retail clinic use and scope of practice were associated with emergency department visits and hospitalizations. We found that visits to retail clinics were associated with lower costs per episode, compared to episodes of care that did not begin with a retail clinic visit, and the costs were even lower when NPs practiced independently. Eliminating restrictions on NPs' scope of practice could have a large impact on the cost savings that can be achieved by retail clinics.

  17. Relationships between Preferred Learning and Clinical Achievement of Baccalaureate Nursing Students.

    ERIC Educational Resources Information Center

    Wilkerson, Norma Neahr

    Paper presented at the Regional achievement in a nursing course in an integrated curriculum were studied. The theoretical framework was based on Kolb's model of experiential learning, which posited four phases: concrete experience, reflective observation, abstract conceptualization, and active experimentation. Kolb's Learning Style Inventory was…

  18. Randomization in clinical trials in orthodontics: its significance in research design and methods to achieve it.

    PubMed

    Pandis, Nikolaos; Polychronopoulou, Argy; Eliades, Theodore

    2011-12-01

    Randomization is a key step in reducing selection bias during the treatment allocation phase in randomized clinical trials. The process of randomization follows specific steps, which include generation of the randomization list, allocation concealment, and implementation of randomization. The phenomenon in the dental and orthodontic literature of characterizing treatment allocation as random is frequent; however, often the randomization procedures followed are not appropriate. Randomization methods assign, at random, treatment to the trial arms without foreknowledge of allocation by either the participants or the investigators thus reducing selection bias. Randomization entails generation of random allocation, allocation concealment, and the actual methodology of implementing treatment allocation randomly and unpredictably. Most popular randomization methods include some form of restricted and/or stratified randomization. This article introduces the reasons, which make randomization an integral part of solid clinical trial methodology, and presents the main randomization schemes applicable to clinical trials in orthodontics.

  19. The role of effective communication in achieving informed consent for clinical trials.

    PubMed

    Pick, Andrew; Gilbert, Kayleigh; McCaul, James

    2014-11-11

    Informed consent is fundamental to the protection of the rights, safety and wellbeing of patients in clinical research. For consent to be valid, patients must first be given all the information they need about the proposed research to be able to decide whether they would like to take part. This material should be presented in a way that is easy for them to understand. This article explores the importance of communication in clinical research, and how more effective communication with patients during the informed consent process can ensure they are fully informed.

  20. Nuclear imaging of the breast: translating achievements in instrumentation into clinical use.

    PubMed

    Hruska, Carrie B; O'Connor, Michael K

    2013-05-01

    Approaches to imaging the breast with nuclear medicine and∕or molecular imaging methods have been under investigation since the late 1980s when a technique called scintimammography was first introduced. This review charts the progress of nuclear imaging of the breast over the last 20 years, covering the development of newer techniques such as breast specific gamma imaging, molecular breast imaging, and positron emission mammography. Key issues critical to the adoption of these technologies in the clinical environment are discussed, including the current status of clinical studies, the efforts at reducing the radiation dose from procedures associated with these technologies, and the relevant radiopharmaceuticals that are available or under development. The necessary steps required to move these technologies from bench to bedside are also discussed.

  1. Nuclear imaging of the breast: Translating achievements in instrumentation into clinical use

    PubMed Central

    Hruska, Carrie B.; O'Connor, Michael K.

    2013-01-01

    Approaches to imaging the breast with nuclear medicine and/or molecular imaging methods have been under investigation since the late 1980s when a technique called scintimammography was first introduced. This review charts the progress of nuclear imaging of the breast over the last 20 years, covering the development of newer techniques such as breast specific gamma imaging, molecular breast imaging, and positron emission mammography. Key issues critical to the adoption of these technologies in the clinical environment are discussed, including the current status of clinical studies, the efforts at reducing the radiation dose from procedures associated with these technologies, and the relevant radiopharmaceuticals that are available or under development. The necessary steps required to move these technologies from bench to bedside are also discussed. PMID:23635248

  2. Achieving quality and fiscal outcomes in patient care: the clinical mentor care delivery model.

    PubMed

    Burritt, Joan E; Wallace, Patricia; Steckel, Cynthia; Hunter, Anita

    2007-12-01

    Contemporary patient care requires sophisticated clinical judgment and reasoning in all nurses. However, the level of development regarding these abilities varies within a staff. Traditional care models lack the structure and process to close the expertise gap creating potential patient safety risks. In an innovative model, senior, experienced nurses were relieved of direct patient care assignments to oversee nursing care delivery. Evaluation of the model showed significant impact on quality and fiscal outcomes.

  3. Achieving clinical statement interoperability using R-MIM and archetype-based semantic transformations.

    PubMed

    Kilic, Ozgur; Dogac, Asuman

    2009-07-01

    Effective use of electronic healthcare records (EHRs) has the potential to positively influence both the quality and the cost of health care. Consequently, sharing patient's EHRs is becoming a global priority in the healthcare information technology domain. This paper addresses the interoperability of EHR structure and content. It describes how two different EHR standards derived from the same reference information model (RIM) can be mapped to each other by using archetypes, refined message information model (R-MIM) derivations, and semantic tools. It is also demonstrated that well-defined R-MIM derivation rules help tracing the class properties back to their origins when the R-MIMs of two EHR standards are derived from the same RIM. Using well-defined rules also enable finding equivalences in the properties of the source and target EHRs. Yet an R-MIM still defines the concepts at the generic level. Archetypes (or templates), on the other hand, constrain an R-MIM to domain-specific concepts, and hence, provide finer granularity semantics. Therefore, while mapping clinical statements between EHRs, we also make use of the archetype semantics. Derivation statements are inferred from the Web Ontology Language definitions of the RIM, the R-MIMs, and the archetypes. Finally, we show how to transform Health Level Seven clinical statement instances to EHRcom clinical statement instances and vice versa by using the generated mapping definitions.

  4. A True Training Needs Analysis.

    ERIC Educational Resources Information Center

    Nowack, Kenneth M.

    1991-01-01

    Employees often want training in areas that are irrelevant to their jobs or inconsistent with organizational objectives. A well-designed questionnaire can weed out training wants to uncover an employee's true training needs. (Author)

  5. Towards Achieving the Full Clinical Potential of Proton Therapy by Inclusion of LET and RBE Models

    PubMed Central

    Jones, Bleddyn

    2015-01-01

    Despite increasing use of proton therapy (PBT), several systematic literature reviews show limited gains in clinical outcomes, with publications mostly devoted to recent technical developments. The lack of randomised control studies has also hampered progress in the acceptance of PBT by many oncologists and policy makers. There remain two important uncertainties associated with PBT, namely: (1) accuracy and reproducibility of Bragg peak position (BPP); and (2) imprecise knowledge of the relative biological effect (RBE) for different tissues and tumours, and at different doses. Incorrect BPP will change dose, linear energy transfer (LET) and RBE, with risks of reduced tumour control and enhanced toxicity. These interrelationships are discussed qualitatively with respect to the ICRU target volume definitions. The internationally accepted proton RBE of 1.1 was based on assays and dose ranges unlikely to reveal the complete range of RBE in the human body. RBE values are not known for human (or animal) brain, spine, kidney, liver, intestine, etc. A simple efficiency model for estimating proton RBE values is described, based on data of Belli et al. and other authors, which allows linear increases in α and β with LET, with a gradient estimated using a saturation model from the low LET α and β radiosensitivity parameter input values, and decreasing RBE with increasing dose. To improve outcomes, 3-D dose-LET-RBE and bio-effectiveness maps are required. Validation experiments are indicated in relevant tissues. Randomised clinical studies that test the invariant 1.1 RBE allocation against higher values in late reacting tissues, and lower tumour RBE values in the case of radiosensitive tumours, are also indicated. PMID:25790470

  6. Poster — Thur Eve — 12: Implementation of a Clinical Lung Tumour High Dose Containment Verification Procedure using Respiratory Cone-Beam CT (4DCBCT) on a Varian TrueBeam Linac

    SciTech Connect

    Beaudry, J.; Bergman, A.

    2014-08-15

    Lung tumours move due to respiratory motion. This is managed during planning by acquiring a 4DCT and capturing the excursion of the GTV (gross tumour volume) throughout the breathing cycle within an IGTV (Internal Gross Tumour Volume) contour. Patients undergo a verification cone-beam CT (CBCT) scan immediately prior to treatment. 3D reconstructed images do not consider tumour motion, resulting in image artefacts, such as blurring. This may lead to difficulty in identifying the tumour on reconstructed images. It would be valuable to create a 4DCBCT reconstruction of the tumour motion to confirm that does indeed remain within the planned IGTV. CBCT projections of a Quasar Respiratory Motion Phantom are acquired in Treatment mode (half-fan scan) on a Varian TrueBeam accelerator. This phantom contains a mobile, low-density lung insert with an embedded 3cm diameter tumour object. It is programmed to create a 15s periodic, 2cm (sup/inf) displacement. A Varian Real-time Position Management (RPM) tracking-box is placed on the phantom breathing platform. Breathing phase information is automatically integrated into the projection image files. Using in-house Matlab programs and RTK (Reconstruction Tool Kit) open-source toolboxes, the projections are re-binned into 10 phases and a 4DCBCT scan reconstructed. The planning IGTV is registered to the 4DCBCT and the tumour excursion is verified to remain within the planned contour. This technique successfully reconstructs 4DCBCT images using clinical modes for a breathing phantom. UBC-BCCA ethics approval has been obtained to perform 4DCBCT reconstructions on lung patients (REB#H12-00192). Clinical images will be accrued starting April 2014.

  7. On achieving a clinically useful D-T neutron isocentric therapy system

    SciTech Connect

    Hilton, J.L.; Hendry, G.O.

    1981-04-01

    The Cyclotron Corporation's Model 4100 Neutron Cancer Therapy System with its output of 8 x 10/sup 12/ (14 MeV) neutron/sec designed for 500 hours is made up of: a factory recyclable miniature 200 kV sealed tube which radially accelerates up to 450 mA of deuterium and tritium ions from four duoplasmatron-type ion sources onto a central target; hand changeable radiation collimators; boronated hydrogenous shielding; isocentric gantry mounting; clinical diagnostics; and controls. The self-contained gas handling system which provides the needed differential gas pressure also stores, pumps, cleans, and recycles the D-T inventory. It is composed of a reversible getter high vacuum pump, a selective noble gas sputter ion pump, and a specialized uranium trap which, by controlled thermal decomposition of uranium hydride, regulates the ion source pressure. A D-T gas inventory of 3.7 k curies provides beam-on time of about three hours, while the gas recycle requires one to two hours. The four-sided target is made up from an array of heat transfer-optimized small copper tubes and their metal surface cladding which results in relatively high neutron output and long target life. The double vacuum walls, providing redundant tritium containment, are combined with other safety features.

  8. Fostering Dental Students' Academic Achievements and Reflection Skills Through Clinical Peer Assessment and Feedback.

    PubMed

    Tricio, Jorge A; Woolford, Mark J; Escudier, Michael P

    2016-08-01

    Peer assessment is increasingly being encouraged to enhance dental students' learning. The aim of this study was to evaluate the educational impact in terms of academic achievements and reflective thinking of a formative prospective peer assessment and feedback protocol. Volunteer final-year dental students at King's College London Dental Institute, UK, received training on peer assessment, peer feedback, and self-reflection. At the beginning (baseline) and end (resultant) of the 2012-13 academic year, 86 students (55% of the year group) completed a reflection questionnaire (RQ). Sixty-eight of those students used a modified Direct Observation of Procedural Skills (DOPS) as a framework for peer assessment and peer feedback during a complete academic year. End-of-year, high-stakes examination grades and RQ scores from the participants and nonparticipants were statistically compared. The participants completed 576 peer DOPS. Those 22 students who peer assessed each other ≥10 times exhibited highly statistically significant differences and powerful positive effect sizes in their high-stakes exam grades (p=0.0001, d=0.74) and critical reflection skills (p=0.005, d=1.41) when compared to those who did not assess one another. Furthermore, only the same 22 students showed a statistically significant increase and positive effect size in their critical reflection skills from baseline to resultant (p=0.003, d=1.04). The results of this study suggest that the protocol used has the potential to impact dental students' academic and reflection skills, provided it is practiced in ten or more peer encounters and ensuring peer feedback is provided followed by self-reflection.

  9. Achieving hemostasis with topical hemostats: making clinically and economically appropriate decisions in the surgical and trauma settings.

    PubMed

    Schreiber, Martin A; Neveleff, Deborah J

    2011-11-01

    Achieving hemostasis is a crucial focus of clinicians working in surgical and trauma settings. Topical hemostatic agents-including mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants-are frequently used in efforts to control bleeding, and new options such as hemostatic dressings, initially used in combat situations, are increasingly being used in civilian settings. To achieve successful hemostasis, a number of vital factors must be considered by surgeons and perioperative nurses, such as the size of the wound; bleeding severity; and the efficacy, possible adverse effects, and method of application of potential hemostatic agents. Understanding how and when to use each of the available hemostatic agents can greatly affect clinical outcomes and help to limit the overall cost of treatment.

  10. Definition of True Score Appropriate for Estimated True Scores

    ERIC Educational Resources Information Center

    Stanley, Julian C.

    1970-01-01

    It is shown that all obtained scores must meet the requirements for classical test-score theory with respect to definitions of true scores and errors of measurement if that frame of reference is to yield valid variance errors of measurement. (DG)

  11. Proficiency testing linked to the national reference system for the clinical laboratory: a proposal for achieving accuracy.

    PubMed

    Lasky, F D

    1992-07-01

    I propose using proficiency testing (PT) to achieve one of the important goals of CLIA: accurate and reliable clinical testing. Routine methods for the clinical laboratory are traceable to Definitive (DM) or Reference Methods (RM) or to Methodological Principles (MP) through a modification of the National Reference System for the Clinical Laboratory. PT is the link used to monitor consistent field performance. Although PT has been effective as a relative measure of laboratory performance, the technical limitations of PT fluids and of routine methods currently in use make it unlikely that PT alone can be used as a reliable measure of laboratory accuracy. Instead, I recommend calibration of routine systems through correlation to DM, RM, or MP with use of patients' specimens. The manufacturer is in the best position to assume this responsibility because of also being responsible for consistent, reliable product. Analysis of different manufactured batches of reagent would be compared with predetermined goals for precision and accuracy, as illustrated with data from product testing of Kodak Ektachem clinical chemistry slides. Adoption of this proposal would give manufacturers of PT materials, manufacturers of analytical systems, PT providers, and government agencies time to understand and resolve sources of error that limit the utility of PT for the job required by law.

  12. Exemplary Care and Learning Sites: A Model for Achieving Continual Improvement in Care and Learning in the Clinical Setting

    PubMed Central

    Ogrinc, Greg; Hoffman, Kimberly G.; Stevenson, Katherine M.; Shalaby, Marc; Beard, Albertine S.; Thörne, Karin E.; Coleman, Mary T.; Baum, Karyn D.

    2016-01-01

    Problem Current models of health care quality improvement do not explicitly describe the role of health professions education. The authors propose the Exemplary Care and Learning Site (ECLS) model as an approach to achieving continual improvement in care and learning in the clinical setting. Approach From 2008–2012, an iterative, interactive process was used to develop the ECLS model and its core elements—patients and families informing process changes; trainees engaging both in care and the improvement of care; leaders knowing, valuing, and practicing improvement; data transforming into useful information; and health professionals competently engaging both in care improvement and teaching about care improvement. In 2012–2013, a three-part feasibility test of the model, including a site self-assessment, an independent review of each site’s ratings, and implementation case stories, was conducted at six clinical teaching sites (in the United States and Sweden). Outcomes Site leaders reported the ECLS model provided a systematic approach toward improving patient (and population) outcomes, system performance, and professional development. Most sites found it challenging to incorporate the patients and families element. The trainee element was strong at four sites. The leadership and data elements were self-assessed as the most fully developed. The health professionals element exhibited the greatest variability across sites. Next Steps The next test of the model should be prospective, linked to clinical and educa tional outcomes, to evaluate whether it helps care delivery teams, educators, and patients and families take action to achieve better patient (and population) outcomes, system performance, and professional development. PMID:26760058

  13. Organizational Designs for Achieving High Treatment Trial Enrollment: A Fuzzy-Set Analysis of the Community Clinical Oncology Program

    PubMed Central

    Weiner, Bryan J.; Jacobs, Sara R.; Minasian, Lori M.; Good, Marjorie J.

    2012-01-01

    Purpose: To examine the organizational design features that were consistently associated in 2010 with high levels of patient enrollment onto National Cancer Institute (NCI) cancer treatment trials among the oncology practices and hospitals participating in the NCI Community Clinical Oncology Program (CCOP). Methods: Fuzzy-set qualitative comparative analysis was used to identify the recipes (ie, combinations of organizational design features) that CCOPs used to achieve high levels of patient enrollment onto NCI treatment trials in 2010. Four organizational design features were examined: number of open treatment trials with at least one patient enrolled, number of newly diagnosed patients with cancer, number of CCOP-affiliated physicians, and number of CCOP-affiliated hospitals or practices where patient enrollment could occur. Data were obtained from NCI data systems and CCOP grant progress reports. Results: Two recipes were consistently associated with high levels of patient enrollment onto NCI treatment trials in 2010: having many open treatment trials and many new patients with cancer, and having many open treatment trials and many affiliated hospitals or practices. Together, these recipes accounted for nearly two thirds of CCOP membership in the high-performance set in 2010. Conclusion: No single organizational design feature, by itself, was consistently associated with high levels of patient enrollment onto NCI treatment trials in 2010. Having a large menu of active treatment trials may be necessary to achieve high–patient enrollment performance, but this is not sufficient unless combined with either large patient volume or many participating sites. PMID:23277765

  14. Two Flavonolignans from Milk Thistle (Silybum marianum) Inhibit CYP2C9-Mediated Warfarin Metabolism at Clinically Achievable Concentrations

    PubMed Central

    Brantley, Scott J.; Oberlies, Nicholas H.; Kroll, David J.

    2010-01-01

    Milk thistle (Silybum marianum) is a popular herbal product used for hepatoprotection and chemoprevention. Two commercially available formulations are the crude extract, silymarin, and the semipurified product, silibinin. Silymarin consists of at least seven flavonolignans, of which the most prevalent are the diastereoisomers silybin A and silybin B; silibinin consists only of silybin A and silybin B. Based on a recent clinical study showing an interaction between a silymarin product and the CYP2C9 substrate losartan, the CYP2C9 inhibition properties of silybin A and silybin B and corresponding regioisomers, isosilybin A and isosilybin B, were evaluated using human liver microsomes (HLMs), recombinant CYP2C9 (rCYP2C9) enzymes, and the clinically relevant probe, (S)-warfarin. Silybin B was the most potent inhibitor in HLMs, followed by silybin A, isosilybin B, and isosilybin A (IC50 of 8.2, 18, 74, and >100 μM, respectively). Next, silybin A and silybin B were selected for further characterization. As with HLMs, silybin B was more potent than silybin A toward rCYP2C9*1 (6.7 versus 12 μM), rCYP2C9*2 (9.3 versus 19 μM), and rCYP2C9*3 (2.4 versus 9.3 μM). Using a matrix of five substrate (1–15 μM) and six inhibitor (1–80 μM) concentrations and HLMs, both diastereoisomers inhibited (S)-warfarin 7-hydroxylation in a manner described best by a mixed-type inhibition model (Ki values of 4.8 and 10 μM for silybin B and silybin A, respectively). These observations, combined with the high systemic silibinin concentrations (>5–75 μM) achieved in a phase I study involving prostate cancer patients, prompt clinical evaluation of a potential warfarin-milk thistle interaction. PMID:19934397

  15. True anteroposterior view pedicle screw insertion technique

    PubMed Central

    Bai, Jia-yue; Zhang, Wei; An, Ji-long; Sun, Ya-peng; Ding, Wen-yuan; Shen, Yong

    2016-01-01

    Background The wide use of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) surgery in the treatment of degenerative disc disease of lumbar spine in spinal surgery highlights the gradual decrease in the use of traditional pedicle screw insertion technology. This study aims to analyze the accuracy of the true anteroposterior view pedicle screw insertion technique in MIS-TLIF surgery, compare it with conventional pedicle screw insertion technology, and discuss its clinical application value. Methods Fifty-two patients undergoing true anteroposterior view (group A) and 87 patients undergoing conventional pedicle screw insertion (group B) were diagnosed with lumbar disc herniation or lumbar spinal stenosis. Time for screw placement, intraoperative irradiation exposure, accuracy rate of pedicle screw insertion, and incidence of neurovascular injury were compared between the two groups. Results The time for screw placement and intraoperative irradiation exposure was significantly less in group A. Penetration rates of the paries lateralis of vertebral pedicle, medial wall of vertebral pedicle, and anterior vertebral wall were 1.44%, 0%, and 2.40%, respectively, all of which were significantly lower than that in group B. No additional serious complications caused by the placement of screw were observed during the follow-up period in patients in group A, but two patients with medial penetration underwent revision for unbearable radicular pain. Conclusion The application of true anteroposterior view pedicle screw insertion technique in MIS-TLIF surgery shortens time for screw placement and reduces the intraoperative irradiation exposure along with a higher accuracy rate of screw placement, which makes it a safe, accurate, and efficient technique. PMID:27418828

  16. Diagnostic pitfalls associated with a large true posterior communicating artery aneurysm: a case report.

    PubMed

    Nagatani, Kimihiro; Otani, Naoki; Seno, Soichiro; Takeuchi, Satoru; Wada, Kojiro; Mori, Kentaro

    2013-10-01

    True posterior communicating artery (PCoA) aneurysm is an aneurysm that originates from the PCoA, and large or giant true PCoA aneurysms are rare. We report a case of a large true PCoA aneurysm successfully clipped after anterior clinoidectomy and discuss the diagnostic pitfalls associated with this rare clinical entity.

  17. Seeking the True Antarctic Ocean

    NASA Astrophysics Data System (ADS)

    Miller, R. G.

    2007-12-01

    With World Ocean warming a corrected name use is recommend with a universal adoption of the name, "Antarctic Ocean. This one large body of circumpolar water lies adjacent to - and south of - the Antarctic Convergence, on its northern perimeter, and is bordered to the south by the shoreline of the Antarctic continent. The Antarctic Ocean has a distinct water mass, with a true perimeter, and with a homogeneity, comprizing a unique environment for a specialized flora and fauna. It is recognized generally by its surface waters, ranging from 3.5 - 4.5 degrees Celsius (summer) and one degree C (winter).While its northern boundary, ' The Antarctic Convergence', has a water quality and thermal difference, this polar front is continuous and circumpolar, and it abuts -- and streams along with -- the ultimate southern extremities of the Atlantic, Pacific and Indian Ocean waters. Parameters, characteristics and dynamics of water exchange are considered, here, with some water exchanges, with Intermediate and Antarctic Bottom water noted. It maintains its own forceful 'West Wind Drift', a current driven and emboldened by Earth's Geostrophic West Wind. Features defining the Antarctic Ocean: (1)Washing all shores of the continent named Antarctica; it is .the only ocean reaching this Antarctic Continent.; (2) it is one of Earth's two Polar (and coldest) oceans, the other, named Arctic Ocean, of which it is the opposite (the Anti); (3) its distinctive cold waters of the Antarctic Ocean and its peripheral seas, floating ice tongues, the frigid stamp of Antarctica's continental glaciers and ice fields; (4) the Antarctic Continent is the source of continual replenishment from her ice cap and melt-water derived from the great mountains, valleys and the massive polar dome of ice. Further, in the literature the present usage, 'Southern Ocean', by some authors, confuses the true Antarctic environmental waters (i.e. south of - and within the South Polar Front - Convergence) with southern

  18. True 3d Images and Their Applications

    NASA Astrophysics Data System (ADS)

    Wang, Z.; wang@hzgeospace., zheng.

    2012-07-01

    A true 3D image is a geo-referenced image. Besides having its radiometric information, it also has true 3Dground coordinates XYZ for every pixels of it. For a true 3D image, especially a true 3D oblique image, it has true 3D coordinates not only for building roofs and/or open grounds, but also for all other visible objects on the ground, such as visible building walls/windows and even trees. The true 3D image breaks the 2D barrier of the traditional orthophotos by introducing the third dimension (elevation) into the image. From a true 3D image, for example, people will not only be able to read a building's location (XY), but also its height (Z). true 3D images will fundamentally change, if not revolutionize, the way people display, look, extract, use, and represent the geospatial information from imagery. In many areas, true 3D images can make profound impacts on the ways of how geospatial information is represented, how true 3D ground modeling is performed, and how the real world scenes are presented. This paper first gives a definition and description of a true 3D image and followed by a brief review of what key advancements of geospatial technologies have made the creation of true 3D images possible. Next, the paper introduces what a true 3D image is made of. Then, the paper discusses some possible contributions and impacts the true 3D images can make to geospatial information fields. At the end, the paper presents a list of the benefits of having and using true 3D images and the applications of true 3D images in a couple of 3D city modeling projects.

  19. Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations

    PubMed Central

    Boland, I; Vassal, G; Morizet, J; Terrier-Lacombe, M-J; Valteau-Couanet, D; Kalifa, C; Hartmann, O; Gouyette, A

    1999-01-01

    High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced stage subcutaneous paediatric solid tumour xenografts. Because busulphan is highly insoluble in water, the use of several vehicles for enteral and parenteral administration was first investigated in terms of pharmacokinetics and toxicity. The highest bioavailability was obtained with busulphan in DMSO administered i.p. When busulphan was suspended in carboxymethylcellulose and given orally or i.p., the bioavailability was poor. Then, in the therapeutic experiments, busulphan in DMSO was administered i.p. on days 0 and 4. At the maximum tolerated total dose (50 mg kg−1), busulphan induced a significant tumour growth delay, ranging from 12 to 34 days in the three neuroblastomas evaluated and in one out of three medulloblastomas. At a dose level above the maximum tolerated dose, busulphan induced complete and partial tumour regressions. Busulphan was inactive in a peripheral primitive neuroectodermal tumour (PNET) xenograft. When busulphan pharmacokinetics in mice and humans were considered, the estimated systemic exposure at the therapeutically active dose in mice (113 μg h ml−1) was close to the mean total systemic exposure in children receiving high-dose busulphan (102.4 μg h ml−1). In conclusion, busulphan displayed a significant anti-tumour activity in neuroblastoma and medulloblastoma xenografts at plasma drug concentrations which can be achieved clinically in children receiving high-dose busulphan-containing regimens. 1999 Cancer Research Campaign PMID:10070870

  20. True hermaphroditism in 45,X/46,XY mosaicism.

    PubMed

    Linskens, R K; Odink, R J; van der Linden, J C; Ekkelkamp, S; Delemarre-van de Waal, H A

    1992-01-01

    This report discusses the clinical findings on two patients with 45,X/46,XY mosaicism, two boys presented with penile hypospadias and cryptorchidism. A dysgenetic ovary and a testis were found in one boy, and a dysgenetic ovary in the other. Both patients can be considered to be true hermaphrodites on the basis of histology and clinical and hormonal observations. 45,X/46,XY mosaics have a wide range of phenotypic appearances and their gonadal morphology can also show great differences. However, the incidence of true hermaphroditism in individuals with 45,X/46,XY mosaicism is low and the reports in the literature rare. It is likely that males with 45,X/46,XY who suffer only mild maldevelopment of the external genitalia will not be recognized. In all patients with penoscrotal hypospadias and cryptorchidism with 45,X/46,XY mosaicism, the possibility of true hermaphroditism should be considered.

  1. Mars in True Color (almost)

    NASA Technical Reports Server (NTRS)

    2003-01-01

    [figure removed for brevity, see original site]

    Released 14 November 2003

    This spectacular view of the sunlit cliffs and basaltic sand dunes in southern Melas Chasma shows Mars in a way rarely seen: in full, realistic color. The colorization is the result of a collaboration between THEMIS team members at Cornell University and space artist Don Davis, who is an expert on true-color renderings of planetary and astronomical objects. Davis began with calibrated and co-registered THEMIS VIS multi-band radiance files produced by the Cornell group. Using as a guide true-color imaging from the Hubble Space Telescope and his own personal experience at Mt. Wilson and other observatories, he performed a manual color balance to match more closely the colors of previous visual Mars observations. He also did some manual smoothing and other image processing to minimize the effects of residual scattered light in the images. The result is a view of Mars that invites comparisons to Earth; a scene that one might observe out the window on a flight over the southwest United States, but not quite. The basaltic dunes are commonplace on Mars but a rare feature on Earth. The rounded knobs and elongated mesas on the canyon floor show an erosional style as exotic as Utah's Bryce Canyon but wholly familiar on Mars. Although the inhospitable Martian atmosphere cannot be seen, the magnificent Martian landscape on display in this image beckons space-suited human explorers and the sightseers who will follow.

    Initial image processing and calibration by THEMIS team members J. Bell, T. McConnochie, and D. Savransky at Cornell University; additional processing and final color balance by space artist Don Davis.

    Image information: VIS instrument. Latitude -12.7, Longitude 288.6 East (71.4 West). 19 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed

  2. Emotional content of true and false memories.

    PubMed

    Laney, Cara; Loftus, Elizabeth F

    2008-01-01

    Many people believe that emotional memories (including those that arise in therapy) are particularly likely to represent true events because of their emotional content. But is emotional content a reliable indicator of memory accuracy? The current research assessed the emotional content of participants' pre-existing (true) and manipulated (false) memories for childhood events. False memories for one of three emotional childhood events were planted using a suggestive manipulation and then compared, along several subjective dimensions, with other participants' true memories. On most emotional dimensions (e.g., how emotional was this event for you?), true and false memories were indistinguishable. On a few measures (e.g., intensity of feelings at the time of the event), true memories were more emotional than false memories in the aggregate, yet true and false memories were equally likely to be rated as uniformly emotional. These results suggest that even substantial emotional content may not reliably indicate memory accuracy.

  3. Achieving appropriate design for developing world heath care: the case of a low-cost autoclave for primary health clinics.

    PubMed

    Cho, Hallie S; Tao, Gregory D; Winter, Amos

    2012-01-01

    In developing world health clinics, incidence of surgical site infection is 2 to 10 times higher than in developed world hospitals. This paper identifies lack of availability of appropriately designed, low-cost autoclaves in developing world health clinics as a major contributing factor to the dramatic gap in surgical site infection rates. The paper describes the process of developing a low-cost autoclave that addresses the unique challenges faced by developing world primary health clinics and discusses how appropriateness of design was determined. The resulting pressure cooker-based autoclave design was fabricated and tested against the CDC specifications. Twelve partnering clinics in Nepal trialed these autoclaves from July until December 2012.

  4. Pediatric Oncology Clinic Care Model: Achieving Better Continuity of Care for Patients in a Medium-sized Program.

    PubMed

    Johnston, Donna L; Halton, Jacqueline; Bassal, Mylène; Klaassen, Robert J; Mandel, Karen; Ramphal, Raveena; Simpson, Ewurabena; Peckan, Li

    2016-10-25

    Providing the best care in both the inpatient and outpatient settings to pediatric oncology patients is all programs goal. Using continuous improvement methodologies, we changed from a solely team-based physician care model to a hybrid model. All patients were assigned a dedicated oncologist. There would then be 2 types of weeks of outpatient clinical service. A "Doc of the Day" week where each oncologist would have a specific day in clinic when their assigned patients would be scheduled, and then a "Doc of the Week" week where one physician would cover clinic for the week. Patient satisfaction surveys done before and 14 months after changing the model of care showed that patients were very satisfied with the care they received in both models. A questionnaire to staff 14 months after changing showed that the biggest effect was increased continuity of care, followed by more efficient clinic workflow and increased consistency of care. Staff felt it provided better planning and delivery of care. A hybrid model of care with a primary physician for each patient and assigned clinic days, alternating with weeks of single physician coverage is a feasible model of care for a medium-sized pediatric oncology program.

  5. Incorporating True Research Opportunities into High School Curriculum: A Research and Design Course

    ERIC Educational Resources Information Center

    Naujock, Jennifer

    2009-01-01

    Field research offers students true scientific practice opportunities and experiences that cannot always be achieved in the classroom. Though research suggests the importance of incorporating field-based research into science curriculum, classroom constraints make it difficult to incorporate true research opportunities into general science…

  6. Is It True That Smoking Causes Wrinkles?

    MedlinePlus

    Healthy Lifestyle Quit smoking Is it true that smoking causes wrinkles? Answers from Lowell Dale, M.D. Yes. ... 10, 2014 Original article: http://www.mayoclinic.org/healthy-lifestyle/quit-smoking/expert-answers/smoking/faq-20058153 . Mayo ...

  7. First report on trichomonads from true bugs.

    PubMed

    Smejkalová, Pavla; Votýpka, Jan; Lukes, Julius; Cepicka, Ivan

    2014-06-01

    Although the hindgut of some insects represents a rich source of intestinal trichomonads, their diversity is only poorly understood. The aim of the present study was to investigate the presence and abundance of intestinal trichomonads in true bugs (Heteroptera). We microscopically examined intestinal contents of more than 780 specimens belonging to 28 families of true bugs from localities in China, Ghana and Papua New Guinea for the presence of intestinal endosymbionts. More than 120 samples were examined also by means of PCR using trichomonad-specific primers. We determined sequences of SSU rDNA and ITS region of two isolates of the genus Simplicimonas Cepicka, Hampl et Kulda, 2010 and one isolate of Monocercomonas colubrorum (Hammerschmidt, 1844). Although our results showed that trichomonads are very rare inhabitants of the intestine of true bugs, two of three isolated flagellates belong to species specific for reptiles. The possibility of transmission of trichomonads between reptiles and true bugs is discussed.

  8. Embryonal Tumors With Abundant Neuropil and True Rosettes

    PubMed Central

    Gessi, Marco; Giangaspero, Felice; Lauriola, Libero; Gardiman, Marina; Scheithauer, Bernd W.; Halliday, William; Hawkins, Cynthia; Rosenblum, Marc K.; Burger, Peter C.; Eberhart, Charles G.

    2015-01-01

    Embryonal neoplasms of the central nervous system (CNS) generally arise in the early years of life and behave in a clinically aggressive manner, but vary somewhat in their microscopic appearance. Several groups have reported examples of an embryonal tumor with combined histologic features of ependymoblastoma and neuroblastoma, a lesion referred to as “embryonal tumor with abundant neuropil and true rosettes” (ETANTR). Herein, we present 22 new cases, and additional clinical follow-up on our 7 initially reported cases, to better define the histologic features and clinical behavior of this distinctive neoplasm. It affects infants and arises most often in cerebral cortex, the cerebellum and brainstem being less frequent sites. Unlike other embryonal tumors of the CNS, girls are more commonly affected than boys. On neuroimaging, the tumors appear as large, demarcated, solid masses featuring patchy or no contrast enhancement. Five of our cases (18%) were at least partly cystic. Distinctive microscopic features include a prominent background of mature neuropil punctuated by true rosettes formed of pseudo-stratified embryonal cells circumferentially disposed about a central lumen (true rosettes). Of the 25 cases with available follow-up, 19 patients have died, their median survival being 9 months. Performed on 2 cases, cytogenetic analysis revealed extra copies of chromosome 2 in both. We believe that the ETANTR represents a histologically distinctive form of CNS embryonal tumor. PMID:18987548

  9. Achievement of recommended glucose and blood pressure targets in patients with type 2 diabetes and hypertension in clinical practice – study rationale and protocol of DIALOGUE

    PubMed Central

    2012-01-01

    Background Patients with type 2 diabetes have 2–4 times greater risk for cardiovascular morbidity and mortality than those without, and this is even further aggravated if they also suffer from hypertension. Unfortunately, less than one third of hypertensive diabetic patients meet blood pressure targets, and more than half fail to achieve target HbA1c values. Thus, appropriate blood pressure and glucose control are of utmost importance. Since treatment sometimes fails in clinical practice while clinical trials generally suggest good efficacy, data from daily clinical practice, especially with regard to the use of newly developed anti-diabetic and anti-hypertensive compounds in unselected patient populations, are essential. The DIALOGUE registry aims to close this important gap by evaluating different treatment approaches in hypertensive type 2 diabetic patients with respect to their effectiveness and tolerability and their impact on outcomes. In addition, DIALOGUE is the first registry to determine treatment success based on the new individualized treatment targets recommended by the ADA and the EASD. Methods DIALOGUE is a prospective observational German multicentre registry and will enrol 10,000 patients with both diabetes and hypertension in up to 700 sites. After a baseline visit, further documentations are scheduled at 6, 12 and 24 months. There are two co-primary objectives referring to the most recent guidelines for the treatment of diabetes and hypertension: 1) individual HbA1c goal achievement with respect to anti-diabetic pharmacotherapy and 2) individual blood pressure goal achievement with different antihypertensive treatments. Among the secondary objectives the rate of major cardio-vascular and cerebro-vascular events (MACCE) and the rate of hospitalizations are the most important. Conclusion The registry will be able to gain insights into the reasons for the obvious gap between the demonstrated efficacy and safety of anti-diabetic and anti

  10. All the Vice Chancellor's Neuroscientists: Unity to Achieve Success in Solving Malaysia's Diseases via Upgrading Clinical Services and Neuroscience Research.

    PubMed

    Abdullah, Jafri Malin

    2013-05-01

    President Obama of the United States of America announced this April the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN for short) investment, while Professor Henry Markram's team based in the European Union will spend over a billion euros on the Human Brain Project, breaking through the unknowns in the fifth science of the decade: Neuroscience. Malaysia's growth in the same field needs to be augmented, and thus the Universiti Sains Malaysia's vision is to excel in the field of clinical brain sciences, mind sciences and neurosciences. This will naturally bring up the level of research in the country simultaneously. Thus, a center was recently established to coordinate this venture. The four-year Integrated Neuroscience Program established recently will be a sustainable source of neuroscientists for the country. We hope to establish ourselves by 2020 as a global university with neurosciences research as an important flagship.

  11. Assessing Eating Disorder Risk: The Pivotal Role of Achievement Anxiety, Depression and Female Gender in Non-Clinical Samples

    PubMed Central

    Fragkos, Konstantinos C.; Frangos, Christos C.

    2013-01-01

    The objective of the present study was to assess factors predicting eating disorder risk in a sample of undergraduate students. A structured questionnaire was employed on a random sample (n = 1865) consisting of the following sections: demographics, SCOFF (Sick, Control, One stone, Fat, Food) questionnaire for screening eating disorders and the Achievement Anxiety Test and the Depression, Anxiety and Stress Scale. The students at risk for eating disorders (SCOFF score ≥2) were 39.7%. Eating disorder risk was more frequent in females, students with divorced parents, students who lived alone, students who were seeking a romantic relationship or were married, students who were at a post-secondary vocational institute/college (private-public) educational level and who were more likely to have marks under merit level. Also, the mean scores for the psychological factors of depression, stress and anxiety were higher in students with eating disorder risk. A logistic regression model was produced depicting that depression, stress, female gender, being married and searching for a romantic relationship were risk factors of having an eating disorder risk. The suggested psychological model examined with structural equation modelling signified the role of academic anxiety as an immediate precursor of general anxiety. Hence, college populations in Greece need organized infrastructures of nutrition health services and campaigns to assist in reducing the risk of eating disorders. PMID:23482057

  12. True Cervicothoracic Meningocele: A Rare and Benign Condition

    PubMed Central

    Pessoa, Bruno L.; Lima, Yara

    2015-01-01

    Cervical meningoceles are rare spinal dysraphism, accounting for approximately 7% of all cystic spinal dysraphism. In spite of the rarity, the clinical course is most of the times benign. The surgical treatment includes resection of the lesion and untethering, when presented. We present a 14-day-old female child with true meningoceles who underwent to surgical excision and dura-mater repair. Retrospect analysis of the literature concerning true cervical meningocele is performed. By reporting this illustrative case, we focus on its classification and its differentiation from other types of cervical spinal dysraphism, such as myelocystocele and myelomeningocele. Although its course is benign, it is mandatory a continuum follow up with periodic magnetic resonance imaging of spinal cord, since late neurological deterioration has been described. PMID:26788266

  13. True's beaked whale (Mesoplodon mirus) in Macaronesia.

    PubMed

    Aguilar de Soto, Natacha; Martín, Vidal; Silva, Monica; Edler, Roland; Reyes, Cristel; Carrillo, Manuel; Schiavi, Agustina; Morales, Talia; García-Ovide, Belen; Sanchez-Mora, Anna; Garcia-Tavero, Nerea; Steiner, Lisa; Scheer, Michael; Gockel, Roland; Walker, Dylan; Villa, Enrico; Szlama, Petra; Eriksson, Ida K; Tejedor, Marisa; Perez-Gil, Monica; Quaresma, João; Bachara, Wojtek; Carroll, Emma

    2017-01-01

    The True's beaked whale (Mesoplodon mirus, True 1913) is a poorly known member of the Ziphiidae family. Its distribution in the northern hemisphere is thought to be restricted to the temperate or warm temperate waters of the North Atlantic, while a few stranding records from the southern hemisphere suggest a wider and antitropical distribution, extending to waters from the Atlantic coast of Brazil to South Africa, Mozambique, Australia and the Tasman Sea coast of New Zealand. This paper (i) reports the first molecular confirmation of the occurrence of the True's beaked whale at the southern limit of its distribution recorded in the northeast Atlantic: the Azores and Canary Islands (macaronesian ecoregion); (ii) describes a new colouration for this species using evidence from a whale with molecular species confirmation; and (iii) contributes to the sparse worldwide database of live sightings, including the first underwater video recording of this species and close images of a calf. Species identification was confirmed in two cases using mitochondrial DNA control region and cytochrome b gene markers: a subadult male True's beaked whale that stranded in El Hierro, Canary Islands, in November 2012, and a subadult male found floating dead near Faial, the Azores, in July 2004. The whale that stranded in the Canary Islands had a clearly delimited white area on its head, extending posteriorly from the tip of the beak to cover the blowhole dorsally and the gular grooves ventrally. This colouration contrasts with previous descriptions for the species and it may be rare, but it exemplifies the variability of the colouration of True's beaked whales in the North Atlantic, further confirmed here by live sightings data. The recording of several observations of this species in deep but relatively coastal waters off the Azores and the Canary Islands suggests that these archipelagos may be unique locations to study the behaviour of the enigmatic True's beaked whale.

  14. [Depression as the sign of true self].

    PubMed

    Brazette, M M

    1992-12-01

    Referring to examples from the poetry of Fernando Pessoa and Mário de Sá Carneiro, we draw attention to the narcissistic relationship between mother and baby, to the role of the mirror-image of the mother's face, and to the organization of a false self caused by a deficiency both of that function, and of the narcissistic investment of the child. The false self is a defence mechanism which protects the true self. This may appear as a depressive state with a feeling of loss and emptiness. The depression is, in such cases, a sign and a clue which may lead to the revelation of the true self.

  15. Effects of Achieving Target Measures in Rheumatoid Arthritis on Functional Status, Quality of Life, and Resource Utilization: Analysis of Clinical Practice Data

    PubMed Central

    Joo, Seongjung; Kawabata, Hugh; Al, Maiwenn J.; Allison, Paul D.; Rutten‐van Mölken, Maureen P. M. H.; Frits, Michelle L.; Iannaccone, Christine K.; Shadick, Nancy A.; Weinblatt, Michael E.

    2016-01-01

    Objective To evaluate associations between achieving guideline‐recommended targets of disease activity, defined by the Disease Activity Score in 28 joints using C‐reactive protein level (DAS28‐CRP) <2.6, the Simplified Disease Activity Index (SDAI) ≤3.3, or the Clinical Disease Activity Index (CDAI) ≤2.8, and other health outcomes in a longitudinal observational study. Methods Other defined thresholds included low disease activity (LDA), moderate (MDA), or severe disease activity (SDA). To control for intraclass correlation and estimate effects of independent variables on outcomes of the modified Health Assessment Questionnaire (M‐HAQ), the EuroQol 5‐domain (EQ‐5D; a quality‐of‐life measure), hospitalization, and durable medical equipment (DME) use, we employed mixed models for continuous outcomes and generalized estimating equations for binary outcomes. Results Among 1,297 subjects, achievement (versus nonachievement) of recommended disease targets was associated with enhanced physical functioning and lower health resource utilization. After controlling for baseline covariates, achievement of disease targets (versus LDA) was associated with significantly enhanced physical functioning based on SDAI ≤3.3 (ΔM‐HAQ −0.047; P = 0.0100) and CDAI ≤2.8 (−0.073; P = 0.0003) but not DAS28‐CRP <2.6 (−0.022; P = 0.1735). Target attainment was associated with significantly improved EQ‐5D (0.022–0.096; P < 0.0030 versus LDA, MDA, or SDA). Patients achieving guideline‐recommended disease targets were 36–45% less likely to be hospitalized (P < 0.0500) and 23–45% less likely to utilize DME (P < 0.0100). Conclusion Attaining recommended target disease‐activity measures was associated with enhanced physical functioning and health‐related quality of life. Some health outcomes were similar in subjects attaining guideline targets versus LDA. Achieving LDA is a worthy clinical objective in some patients. PMID:26238974

  16. Automated balance for determining true mass

    SciTech Connect

    Meyer, J.E.

    1982-08-08

    An automated weighing system utilizing a precision electronic balance and a small desktop computer is described. An example of a computer program demonstrating some of the capabilities attainable with this system is included. The program demonstrates a substitution weighing technique with true mass determination for the object being weighed.

  17. How to Make Their Dreams Come True

    ERIC Educational Resources Information Center

    Easley, Dauna

    2005-01-01

    The beginning of January--a fresh start. This presents a brand new opportunity to help students plan a bright future. This article provides a step-by-step guide to ensure a student's dreams come true. Each new year gives students another chance to get it right. The author provides the following 12 steps to ensure students' success in achieving…

  18. Decreased Sperm Motility Retarded ICSI Fertilization Rate in Severe Oligozoospermia but Good-Quality Embryo Transfer Had Achieved the Prospective Clinical Outcomes

    PubMed Central

    Zheng, Jufeng; Lu, Yongning; Qu, Xianqin; Wang, Peng; Zhao, Luiwen; Gao, Minzhi; Shi, Huijuan; Jin, Xingliang

    2016-01-01

    . Overall rates in all groups were 41.26% clinical pregnancy, 25.74% implantation and 36.32% live birth, which gave live birth to 252 girls and 252 boys. Conclusions The reduction of motile spermatozoa in severe oligozoospermia decreased the rates of fertilization and good-quality embryo. Obtaining and transfer of good-quality embryos was the good prognostic to achieve prospective clinical outcomes regardless of the severity of oligozoospermia. PMID:27661081

  19. True 4D Image Denoising on the GPU.

    PubMed

    Eklund, Anders; Andersson, Mats; Knutsson, Hans

    2011-01-01

    The use of image denoising techniques is an important part of many medical imaging applications. One common application is to improve the image quality of low-dose (noisy) computed tomography (CT) data. While 3D image denoising previously has been applied to several volumes independently, there has not been much work done on true 4D image denoising, where the algorithm considers several volumes at the same time. The problem with 4D image denoising, compared to 2D and 3D denoising, is that the computational complexity increases exponentially. In this paper we describe a novel algorithm for true 4D image denoising, based on local adaptive filtering, and how to implement it on the graphics processing unit (GPU). The algorithm was applied to a 4D CT heart dataset of the resolution 512  × 512  × 445  × 20. The result is that the GPU can complete the denoising in about 25 minutes if spatial filtering is used and in about 8 minutes if FFT-based filtering is used. The CPU implementation requires several days of processing time for spatial filtering and about 50 minutes for FFT-based filtering. The short processing time increases the clinical value of true 4D image denoising significantly.

  20. Cosmic chirality both true and false.

    PubMed

    Barron, Laurence D

    2012-12-01

    The discrete symmetries of parity P, time reversal T, and charge conjugation C may be used to characterize the properties of chiral systems. It is well known that parity violation infiltrates into ordinary matter via an interaction between the nucleons and electrons, mediated by the Z(0) particle, that lifts the degeneracy of the mirror-image enantiomers of a chiral molecule. Being odd under P but even under T, this P-violating interaction exhibits true chirality and so may induce absolute enantioselection under all circumstances. It has been suggested that CP violation may also infiltrate into ordinary matter via a P-odd, T-odd interaction mediated by the (as yet undetected) axion. This CP-violating interaction exhibits false chirality and so may induce absolute enantioselection in processes far from equilibrium. Both true and false cosmic chirality should be considered together as possible sources of homochirality in the molecules of life.

  1. Ionospheric true height profiles from oblique ionograms

    SciTech Connect

    Reilly, M.H.

    1985-06-01

    An improved direct technique in which HF oblique ionograms are reduced to ionospheric true height profiles is introduced. The benefits of this method result principally from the use of a more accurate Breit-Tuve relation to curved earth and ionosphere geometries. By comparing the results of calculations on known cases, the extent of improvement with this technique relative to the techniques by Gething and Maliphant (1967), George (1970), and Smith (1970), is demonstrated. 14 references.

  2. True vaginal prolapse in a bitch.

    PubMed

    Alan, M; Cetin, Y; Sendag, S; Eski, F

    2007-08-01

    Frequently, vaginal fold prolapse is the protrusion of edematous vaginal tissue into and through the opening of the vulva occurring during proestrus and estrus stages of the sexual cycle. True vaginal prolapse may occur near parturition, as the concentration of serum progesterone declines and the concentration of serum oestrogen increases. In the bitch, this type of true vaginal prolapse is a very rare condition. This short communication describes a 5-year-old female, cross-breed dog in moderate condition, weighing 33 kg, with distocia and true vaginal prolapse. Abdominal palpation and transabdominal ultrasonography revealed live and dead foetuses in the uterine horns. One dead and four live fetuses were removed from uterus by cesarean section. The ovariohysterectomy was performed after repositioning the vaginal wall with a combination of traction from within the abdomen and external manipulation through the vulva. Re-occurrence of a vaginal prolapse was not observed and the bitch recovered completely after the surgical therapy. Compared to other vaginal disorders, vaginal prolapse is an uncommon condition in the bitch. In the present case, extreme tenesmus arising from distocia may have predisposed to the vaginal prolapse. The cause of dystocia was probably the disposition of the first foetus. We concluded that the vaginal prolapse was the result of dystocia in the present case.

  3. True random numbers from amplified quantum vacuum.

    PubMed

    Jofre, M; Curty, M; Steinlechner, F; Anzolin, G; Torres, J P; Mitchell, M W; Pruneri, V

    2011-10-10

    Random numbers are essential for applications ranging from secure communications to numerical simulation and quantitative finance. Algorithms can rapidly produce pseudo-random outcomes, series of numbers that mimic most properties of true random numbers while quantum random number generators (QRNGs) exploit intrinsic quantum randomness to produce true random numbers. Single-photon QRNGs are conceptually simple but produce few random bits per detection. In contrast, vacuum fluctuations are a vast resource for QRNGs: they are broad-band and thus can encode many random bits per second. Direct recording of vacuum fluctuations is possible, but requires shot-noise-limited detectors, at the cost of bandwidth. We demonstrate efficient conversion of vacuum fluctuations to true random bits using optical amplification of vacuum and interferometry. Using commercially-available optical components we demonstrate a QRNG at a bit rate of 1.11 Gbps. The proposed scheme has the potential to be extended to 10 Gbps and even up to 100 Gbps by taking advantage of high speed modulation sources and detectors for optical fiber telecommunication devices.

  4. Polyphyly of true branching cyanobacteria (Stigonematales).

    PubMed

    Gugger, Muriel F; Hoffmann, Lucien

    2004-03-01

    Cyanobacteria with true branching are classified in Subsection V (formerly order Stigonematales) in the phylum CYANOBACTERIA: They exhibit a high degree of morphological complexity and are known from particular biotopes. Only a few stigonematalean morphotypes have been cultured, and therefore the high variability of morphotypes found in nature is under-represented in culture. Axenic cultures of Chlorogloeopsis and Fischerella sensu Rippka et al. were, to date, the only representatives of this Subsection in phylogenetic studies. The 16S rDNA sequence analysis data in this report confirm that heterocyst-forming cyanobacteria are a monophyletic group. However, unlike previous studies have suggested, these 16S rDNA data on new Stigonematales strains show that the true branching cyanobacteria are polyphyletic and can be separated into at least two major groups defined by their branching type, the first group being characterized by T-branching and the second group by Y-branching. Cyanobacteria with intercalary heterocysts and either no branching or false-branching also formed separate clusters. In consequence, our phylogenetic data do not correlate with the bacteriological and traditional classifications, which distinguish filamentous heterocystous cyanobacteria with or without true branching (Nostocales/Stigonematales).

  5. Effectiveness of Music Education for the Improvement of Reading Skills and Academic Achievement in Young Poor Readers: A Pragmatic Cluster-Randomized, Controlled Clinical Trial

    PubMed Central

    Cogo-Moreira, Hugo; de Ávila, Clara Regina Brandão; Ploubidis, George B.; Mari, Jair de Jesus

    2013-01-01

    Introduction Difficulties in word-level reading skills are prevalent in Brazilian schools and may deter children from gaining the knowledge obtained through reading and academic achievement. Music education has emerged as a potential method to improve reading skills because due to a common neurobiological substratum. Objective To evaluate the effectiveness of music education for the improvement of reading skills and academic achievement among children (eight to 10 years of age) with reading difficulties. Method 235 children with reading difficulties in 10 schools participated in a five-month, randomized clinical trial in cluster (RCT) in an impoverished zone within the city of São Paulo to test the effects of music education intervention while assessing reading skills and academic achievement during the school year. Five schools were chosen randomly to incorporate music classes (n = 114), and five served as controls (n = 121). Two different methods of analysis were used to evaluate the effectiveness of the intervention: The standard method was intention-to-treat (ITT), and the other was the Complier Average Causal Effect (CACE) estimation method, which took compliance status into account. Results The ITT analyses were not very promising; only one marginal effect existed for the rate of correct real words read per minute. Indeed, considering ITT, improvements were observed in the secondary outcomes (slope of Portuguese = 0.21 [p<0.001] and slope of math = 0.25 [p<0.001]). As for CACE estimation (i.e., complier children versus non-complier children), more promising effects were observed in terms of the rate of correct words read per minute [β = 13.98, p<0.001] and phonological awareness [β = 19.72, p<0.001] as well as secondary outcomes (academic achievement in Portuguese [β = 0.77, p<0.0001] and math [β = 0.49, p<0.001] throughout the school year). Conclusion The results may be seen as promising, but they are not, in themselves

  6. TRUE MASSES OF RADIAL-VELOCITY EXOPLANETS

    SciTech Connect

    Brown, Robert A.

    2015-06-01

    We study the task of estimating the true masses of known radial-velocity (RV) exoplanets by means of direct astrometry on coronagraphic images to measure the apparent separation between exoplanet and host star. Initially, we assume perfect knowledge of the RV orbital parameters and that all errors are due to photon statistics. We construct design reference missions for four missions currently under study at NASA: EXO-S and WFIRST-S, with external star shades for starlight suppression, EXO-C and WFIRST-C, with internal coronagraphs. These DRMs reveal extreme scheduling constraints due to the combination of solar and anti-solar pointing restrictions, photometric and obscurational completeness, image blurring due to orbital motion, and the “nodal effect,” which is the independence of apparent separation and inclination when the planet crosses the plane of the sky through the host star. Next, we address the issue of nonzero uncertainties in RV orbital parameters by investigating their impact on the observations of 21 single-planet systems. Except for two—GJ 676 A b and 16 Cyg B b, which are observable only by the star-shade missions—we find that current uncertainties in orbital parameters generally prevent accurate, unbiased estimation of true planetary mass. For the coronagraphs, WFIRST-C and EXO-C, the most likely number of good estimators of true mass is currently zero. For the star shades, EXO-S and WFIRST-S, the most likely numbers of good estimators are three and four, respectively, including GJ 676 A b and 16 Cyg B b. We expect that uncertain orbital elements currently undermine all potential programs of direct imaging and spectroscopy of RV exoplanets.

  7. [True color accuracy in digital forensic photography].

    PubMed

    Ramsthaler, Frank; Birngruber, Christoph G; Kröll, Ann-Katrin; Kettner, Mattias; Verhoff, Marcel A

    2016-01-01

    Forensic photographs not only need to be unaltered and authentic and capture context-relevant images, along with certain minimum requirements for image sharpness and information density, but color accuracy also plays an important role, for instance, in the assessment of injuries or taphonomic stages, or in the identification and evaluation of traces from photos. The perception of color not only varies subjectively from person to person, but as a discrete property of an image, color in digital photos is also to a considerable extent influenced by technical factors such as lighting, acquisition settings, camera, and output medium (print, monitor). For these reasons, consistent color accuracy has so far been limited in digital photography. Because images usually contain a wealth of color information, especially for complex or composite colors or shades of color, and the wavelength-dependent sensitivity to factors such as light and shadow may vary between cameras, the usefulness of issuing general recommendations for camera capture settings is limited. Our results indicate that true image colors can best and most realistically be captured with the SpyderCheckr technical calibration tool for digital cameras tested in this study. Apart from aspects such as the simplicity and quickness of the calibration procedure, a further advantage of the tool is that the results are independent of the camera used and can also be used for the color management of output devices such as monitors and printers. The SpyderCheckr color-code patches allow true colors to be captured more realistically than with a manual white balance tool or an automatic flash. We therefore recommend that the use of a color management tool should be considered for the acquisition of all images that demand high true color accuracy (in particular in the setting of injury documentation).

  8. True Masses of Radial-Velocity Exoplanets

    NASA Astrophysics Data System (ADS)

    Brown, Robert A.

    2015-06-01

    We study the task of estimating the true masses of known radial-velocity (RV) exoplanets by means of direct astrometry on coronagraphic images to measure the apparent separation between exoplanet and host star. Initially, we assume perfect knowledge of the RV orbital parameters and that all errors are due to photon statistics. We construct design reference missions for four missions currently under study at NASA: EXO-S and WFIRST-S, with external star shades for starlight suppression, EXO-C and WFIRST-C, with internal coronagraphs. These DRMs reveal extreme scheduling constraints due to the combination of solar and anti-solar pointing restrictions, photometric and obscurational completeness, image blurring due to orbital motion, and the “nodal effect,” which is the independence of apparent separation and inclination when the planet crosses the plane of the sky through the host star. Next, we address the issue of nonzero uncertainties in RV orbital parameters by investigating their impact on the observations of 21 single-planet systems. Except for two—GJ 676 A b and 16 Cyg B b, which are observable only by the star-shade missions—we find that current uncertainties in orbital parameters generally prevent accurate, unbiased estimation of true planetary mass. For the coronagraphs, WFIRST-C and EXO-C, the most likely number of good estimators of true mass is currently zero. For the star shades, EXO-S and WFIRST-S, the most likely numbers of good estimators are three and four, respectively, including GJ 676 A b and 16 Cyg B b. We expect that uncertain orbital elements currently undermine all potential programs of direct imaging and spectroscopy of RV exoplanets.

  9. Suspended monolayer graphene under true uniaxial deformation

    NASA Astrophysics Data System (ADS)

    Polyzos, Ioannis; Bianchi, Massimiliano; Rizzi, Laura; Koukaras, Emmanuel N.; Parthenios, John; Papagelis, Konstantinos; Sordan, Roman; Galiotis, Costas

    2015-07-01

    2D crystals, such as graphene, exhibit the higher strength and stiffness of any other known man-made or natural material. So far, this assertion has been primarily based on modelling predictions and on bending experiments in combination with pertinent modelling. True uniaxial loading of suspended graphene is not easy to accomplish; however such an experiment is of paramount importance in order to assess the intrinsic properties of graphene without the influence of an underlying substrate. In this work we report on uniaxial tension of graphene up to moderate strains of ~0.8%. This has been made possible by sandwiching the graphene flake between two polymethylmethacrylate (PMMA) layers and by suspending its central part by the removal of a section of PMMA with e-beam lithography. True uniaxial deformation is confirmed by the measured large phonon shifts with strain by Raman spectroscopy and the indication of lateral buckling (similar to what is observed for thin macroscopic membranes under tension). Finally, we also report on how the stress is transferred to the suspended specimen through the adhesive grips and determine the value of interfacial shear stress that is required for efficient axial loading in such a system.2D crystals, such as graphene, exhibit the higher strength and stiffness of any other known man-made or natural material. So far, this assertion has been primarily based on modelling predictions and on bending experiments in combination with pertinent modelling. True uniaxial loading of suspended graphene is not easy to accomplish; however such an experiment is of paramount importance in order to assess the intrinsic properties of graphene without the influence of an underlying substrate. In this work we report on uniaxial tension of graphene up to moderate strains of ~0.8%. This has been made possible by sandwiching the graphene flake between two polymethylmethacrylate (PMMA) layers and by suspending its central part by the removal of a section of

  10. True bilateral nasopharyngeal angiofibroma: report and review.

    PubMed

    Mishra, Anupam; Mishra, Subhash Chandra

    2016-10-01

    This report describes the third case of a true bilateral Juvenile nasopharyngeal angiofibroma (JNA), i.e. two separate JNA arising from both sides simultaneously. The associated multiple recurrences in such a case have not yet been reported. A 21-year-man underwent transpalatal excision and recurred twice. The last 'neo-occurrence' encountered after 2 years was at a different site and was subsequently managed by post-embolization endoscopic resection. A complete report of its clinico-radiological features and management outcome is discussed.

  11. A Comparison of Multiple-Choice Tests and True-False Tests Used in Evaluating Student Progress

    ERIC Educational Resources Information Center

    Tasdemir, Mehmet

    2010-01-01

    This study aims at comparing the difficulty levels, discrimination powers and powers of testing achievement of multiple choice tests and true-false tests, and thus revealing the rightness or wrongness of the commonly believed hypothesis that multiple choice tests don't bear the same properties as true-false tests. The research was performed with…

  12. In patients with extensive subcutaneous emphysema, which technique achieves maximal clinical resolution: infraclavicular incisions, subcutaneous drain insertion or suction on in situ chest drain?

    PubMed

    Johnson, Charles H N; Lang, Sommer A; Bilal, Haris; Rammohan, Kandadai S

    2014-06-01

    A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: 'In patients with extensive subcutaneous emphysema, which technique achieves maximal clinical resolution: infraclavicular incisions, subcutaneous drain insertion or suction on in situ chest drain?'. Altogether more than 200 papers were found using the reported search, of which 14 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Subcutaneous emphysema is usually a benign, self-limiting condition only requiring conservative management. Interventions are useful in the context of severe patient discomfort, respiratory distress or persistent air leak. In the absence of any comparative study, it is not possible to choose definitively between infraclavicular incisions, drain insertion and increasing suction on an in situ drain as the best method for managing severe subcutaneous emphysema. All the three techniques described have been shown to provide effective relief. Increasing suction on a chest tube already in situ provided rapid relief in patients developing SE following pulmonary resection. A retrospective study showed resolution in 66%, increasing to 98% in those who underwent video-assisted thoracic surgery with identification and closure of the leak. Insertion of a drain into the subcutaneous tissue also provided rapid sustained relief. Several studies aided drainage by using regular compressive massage. Infraclavicular incisions were also shown to provide rapid relief, but were noted to be more invasive and carried the potential for cosmetic defect. No major complications were illustrated.

  13. High bandwidth optical coherent transient true-time delay

    NASA Astrophysics Data System (ADS)

    Reibel, Randy Ray

    An approach to reaching high bandwidth optical coherent transient (OCT) true-time delay (TTD) is described and demonstrated in this thesis. Utilizing the stimulated photon echo process in rare-earth ion doped crystals, such as Tm3+:YAG, TTD of optical signals with bandwidths >20 GHz and high time bandwidth products >104 are possible. TTD regenerators using OCT's have been demonstrated at low bandwidths (<40 MHz) showing picosecond delay resolutions with microsecond delays. With the advent of high bandwidth chirped lasers and high bandwidth electro-optic phase modulators, OCT TTD of broadband optical signals is now possible in the multi-gigahertz regime. To achieve this goal, several theoretical and technical aspects had to be explored. Theoretical discussions and numerical simulations are given using the Maxwell-Bloch equations with arbitrary phase. These simulations show good signal fidelity and high (60%) power efficiencies on echoes produced from gratings programmed with linear frequency chirps. New approaches for programming spectral gratings were also examined that utilized high bandwidth electro-optic modulators. In this technique, the phase modulation sidebands on an optical carrier are linearly chirped, creating an analog to the common linear frequency chirp. This approach allows multi-gigahertz true-time delay spectral grating programming. These new programming approaches are examined and characterized, both through simulation and experiment. A high bandwidth injection locked amplifier, based on semiconductor diode lasers, had to be developed and characterized to boost optical powers from both electro-optic phase modulators as well as chirped lasers. The injection locking system in conjunction with acousto-optic modulators were used in high bandwidth TTD demonstrations in Tm3+:YAG. Ultimately, high bandwidth binary phase shift keyed probe pulses were used in a demonstration of broadband true-time delay at a data rate of 1 GBit/s. The techniques, theory

  14. Suspended monolayer graphene under true uniaxial deformation.

    PubMed

    Polyzos, Ioannis; Bianchi, Massimiliano; Rizzi, Laura; Koukaras, Emmanuel N; Parthenios, John; Papagelis, Konstantinos; Sordan, Roman; Galiotis, Costas

    2015-08-14

    2D crystals, such as graphene, exhibit the higher strength and stiffness of any other known man-made or natural material. So far, this assertion has been primarily based on modelling predictions and on bending experiments in combination with pertinent modelling. True uniaxial loading of suspended graphene is not easy to accomplish; however such an experiment is of paramount importance in order to assess the intrinsic properties of graphene without the influence of an underlying substrate. In this work we report on uniaxial tension of graphene up to moderate strains of ∼0.8%. This has been made possible by sandwiching the graphene flake between two polymethylmethacrylate (PMMA) layers and by suspending its central part by the removal of a section of PMMA with e-beam lithography. True uniaxial deformation is confirmed by the measured large phonon shifts with strain by Raman spectroscopy and the indication of lateral buckling (similar to what is observed for thin macroscopic membranes under tension). Finally, we also report on how the stress is transferred to the suspended specimen through the adhesive grips and determine the value of interfacial shear stress that is required for efficient axial loading in such a system.

  15. A comprehensive study on urban true orthorectification

    USGS Publications Warehouse

    Zhou, G.; Chen, W.; Kelmelis, J.A.; Zhang, Dongxiao

    2005-01-01

    To provide some advanced technical bases (algorithms and procedures) and experience needed for national large-scale digital orthophoto generation and revision of the Standards for National Large-Scale City Digital Orthophoto in the National Digital Orthophoto Program (NDOP), this paper presents a comprehensive study on theories, algorithms, and methods of large-scale urban orthoimage generation. The procedures of orthorectification for digital terrain model (DTM)-based and digital building model (DBM)-based orthoimage generation and their mergence for true orthoimage generation are discussed in detail. A method of compensating for building occlusions using photogrammetric geometry is developed. The data structure needed to model urban buildings for accurately generating urban orthoimages is presented. Shadow detection and removal, the optimization of seamline for automatic mosaic, and the radiometric balance of neighbor images are discussed. Street visibility analysis, including the relationship between flight height, building height, street width, and relative location of the street to the imaging center, is analyzed for complete true orthoimage generation. The experimental results demonstrated that our method can effectively and correctly orthorectify the displacements caused by terrain and buildings in urban large-scale aerial images. ?? 2005 IEEE.

  16. Natural history of true pancreaticoduodenal artery aneurysms

    PubMed Central

    Takao, H; Doi, I; Watanabe, T; Yoshioka, N; Ohtomo, K

    2010-01-01

    Advances in non-invasive diagnostic techniques, such as CT and ultrasonography, have improved our ability to detect unruptured pancreaticoduodenal artery aneurysms. No definitive study evaluating the natural history of these lesions or their preferred method of treatment has been published. In this report, we describe five patients with eight unruptured true pancreaticoduodenal artery aneurysms followed without treatment. Of these patients, four had coeliac axis stenosis (n = 1) or occlusion (n = 3) and one had occlusion of the superior mesenteric artery. The mean diameter of the aneurysms was 12.0 mm (range 7–17 mm). The mean duration of follow-up was 29.4 months (range 6–57 months). There was no aneurysm rupture during a total of 147 patient-months (243 aneurysm-months) of follow-up. Of the eight aneurysms, three increased in size over the follow-up period. We conclude that the risk of rupture of true pancreaticoduodenal artery aneurysms might be lower than expected from the data on ruptured aneurysms; however, careful follow-up of untreated aneurysms is necessary. PMID:20647516

  17. Molecular imaging true-colour spectroscopic optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Robles, Francisco E.; Wilson, Christy; Grant, Gerald; Wax, Adam

    2011-12-01

    Molecular imaging holds a pivotal role in medicine due to its ability to provide invaluable insight into disease mechanisms at molecular and cellular levels. To this end, various techniques have been developed for molecular imaging, each with its own advantages and disadvantages. For example, fluorescence imaging achieves micrometre-scale resolution, but has low penetration depths and is mostly limited to exogenous agents. Here, we demonstrate molecular imaging of endogenous and exogenous chromophores using a novel form of spectroscopic optical coherence tomography. Our approach consists of using a wide spectral bandwidth laser source centred in the visible spectrum, thereby allowing facile assessment of haemoglobin oxygen levels, providing contrast from readily available absorbers, and enabling true-colour representation of samples. This approach provides high spectral fidelity while imaging at the micrometre scale in three dimensions. Molecular imaging true-colour spectroscopic optical coherence tomography (METRiCS OCT) has significant implications for many biomedical applications including ophthalmology, early cancer detection, and understanding fundamental disease mechanisms such as hypoxia and angiogenesis.

  18. New York State TrueAllele® Casework Validation Study*

    PubMed Central

    Perlin, Mark W; Belrose, Jamie L; Duceman, Barry W

    2013-01-01

    DNA evidence can pose interpretation challenges, particularly with low-level or mixed samples. It would be desirable to make full use of the quantitative data, consider every genotype possibility, and objectively produce accurate and reproducible DNA match results. Probabilistic genotype computing is designed to achieve these goals. This validation study assessed TrueAllele® probabilistic computer interpretation on 368 evidence items in 41 test cases and compared the results with human review of the same data. Whenever there was a human result, the computer's genotype was concordant. Further, the computer produced a match statistic on 81 mixture items (for 87 inferred matching genotypes) in the test cases, while human review reported a statistic on 25 of these items (30.9%). Using match statistics to quantify information, probabilistic genotyping was shown to be sensitive, specific, and reproducible. These results demonstrate that objective probabilistic genotyping of biological evidence can reliably preserve DNA identification information. PMID:23865896

  19. Caffeine's effects on true and false memory.

    PubMed

    Capek, Sarah; Guenther, R Kim

    2009-06-01

    Caffeine's effects on recall of word lists were investigated using the Deese-Roediger-McDermott (DRM) paradigm. College students were administered either 200 mg of caffeine or a 250-mg lactose placebo; after 30 min., they were tested on recall using six word lists. Words of each list were semantically related to a single word (a "critical lure") that was not presented in the list. Participants administered caffeine recalled more list words and more critical lures than participants administered lactose. Recall of list words was negatively correlated with recall of critical lures. Caffeine appears to intensify the strength of connections among list words and critical lures, thereby enhancing both true and false memory.

  20. Comparison between true and partial hemifacial hypertrophy.

    PubMed

    Islam, Mohammed N; Bhattacharyya, Indraneel; Ojha, Junu; Bober, Karen; Cohen, Donald M; Green, James G

    2007-10-01

    Hemifacial hypertrophy (HFH) is rare and characterized by unilateral enlargement of the head and teeth. Hemifacial hypertrophy is classified as true HFH (THFH) with unilateral enlargement of the viscerocranium, and partial HFH (PHFH) in which not all structures are enlarged. We present a case of THFH and compare and contrast it with a case of PHFH. Hemifacial hypertrophy may cover a wide spectrum of defects or may involve only muscle or bone. Myohyperplasia, reported previously as a separate syndrome, may actually represent a forme fruste of PHFH or THFH. The PHFH patient lead a healthy, normal life without significant psychosocial problems and was reluctant to accept his deformity. Contrastingly, the THFH patient had significant social stigma and compromised health together with major aesthetic morbidity. Treatment planning in THFH is arduous and involves multiple modalities. Therefore, it is imperative to differentiate THFH and PHFH for better understanding and management of the condition.

  1. Kepler's winding Path to true Heliocentrism

    NASA Astrophysics Data System (ADS)

    Bialas, Volker

    The paper concerns the evolution of concepts by Johannes Kepler from Aristotelian conception of the Universe to Heliocentrism. Already as young Magister in Tubingen Kepler has taken an active part in Physical disputations of the candidates and has defended the doctrines of Copernik (1). In the Mysterium Cosmographicum he refers the planetary distances no longer to the center of the earth's orbit, but to the center of the true sun. But just by working out his Astronomia Nova Kepler succeeds in creating a strictly heliocentric astronomy as his handwriting Manuscripts give detailed information (2). Notes: 1) fragmentum orations de motu terrae. In Keppler Gesammelte werke Vol. 20.1, Munich 1988, p. 147-149 2) Commentaria in Theoriam Martis. Edition in: Kepler Gessamelete Werke Vol. 20.2 (in preparation)

  2. In search of the elusive true surface

    SciTech Connect

    Takacs, P.Z.; Furenlid, K. ); Church, E.L. )

    1990-08-01

    Measurement of an optical surface by a figure measuring device allows one to make an estimate of the shape of the surface. The absolute accuracy in locating the true'' surface depends on the sources of error in the measurement process -- both random errors and systematic errors. Analysis procedures have been developed to extract surface figure information from optical profiler measurements on large mirrors. Rigid-body orientation effects are important in analyzing the shape of the off-axis ellipsoidal reflectors used as gazing incidence mirrors in soft-ray synchrotron instrumentation. Knowledge of the noise level and optical aberration function of the Long Trace Profiler allow us to place error bars smaller than {lambda}/100 on measurements of surfaces that are more than 500 mm long. 6 refs., 11 figs.

  3. In Search of the True Universe

    NASA Astrophysics Data System (ADS)

    Harwit, Martin

    2013-11-01

    1. The nineteenth century's last five years; Part I. The Import of Theoretical Tools: 2. An overview; 3. Conclusions based on principles; 4. Conclusions based on a premise; 5. Conclusions based on calculations; 6. Asking the right questions, accepting limited answers; Part II. A National Plan Shaping the Universe We Perceive: 7. A new order and the new universe it produced; 8. Where did the chemical elements arise?; 9. Landscapes; 10. The evolution of astrophysical theory after 1960; 11. Turmoils of leadership; 12. Cascades and shocks that shape astrophysics; 13. Astrophysical discourse and persuasion; Part III. The Cost of Discerning the True Universe: 14. Organization and functioning of the astronomical community; 15. Language and astrophysical stability; 16. An economically viable astronomical program; Epilogue.

  4. In Search of the True Universe

    NASA Astrophysics Data System (ADS)

    Harwit, Martin

    2014-01-01

    1. The nineteenth century's last five years; Part I. The Import of Theoretical Tools: 2. An overview; 3. Conclusions based on principles; 4. Conclusions based on a premise; 5. Conclusions based on calculations; 6. Asking the right questions, accepting limited answers; Part II. A National Plan Shaping the Universe We Perceive: 7. A new order and the new universe it produced; 8. Where did the chemical elements arise?; 9. Landscapes; 10. The evolution of astrophysical theory after 1960; 11. Turmoils of leadership; 12. Cascades and shocks that shape astrophysics; 13. Astrophysical discourse and persuasion; Part III. The Cost of Discerning the True Universe: 14. Organization and functioning of the astronomical community; 15. Language and astrophysical stability; 16. An economically viable astronomical program; Epilogue.

  5. Uranus in True and False Color

    NASA Technical Reports Server (NTRS)

    1986-01-01

    These two pictures of Uranus -- one in true color (left) and the other in false color -- were compiled from images returned Jan. 17, 1986, by the narrow-angle camera of Voyager 2. The spacecraft was 9.1 million kilometers (5.7 million miles) from the planet, several days from closest approach. The picture at left has been processed to show Uranus as human eyes would see it from the vantage point of the spacecraft. The picture is a composite of images taken through blue, green and orange filters. The darker shadings at the upper right of the disk correspond to the day-night boundary on the planet. Beyond this boundary lies the hidden northern hemisphere of Uranus, which currently remains in total darkness as the planet rotates. The blue-green color results from the absorption of red light by methane gas in Uranus' deep, cold and remarkably clear atmosphere. The picture at right uses false color and extreme contrast enhancement to bring out subtle details in the polar region of Uranus. Images obtained through ultraviolet, violet and orange filters were respectively converted to the same blue, green and red colors used to produce the picture at left. The very slight contrasts visible in true color are greatly exaggerated here. In this false-color picture, Uranus reveals a dark polar hood surrounded by a series of progressively lighter concentric bands. One possible explanation is that a brownish haze or smog, concentrated over the pole, is arranged into bands by zonal motions of the upper atmosphere. The bright orange and yellow strip at the lower edge of the planet's limb is an artifact of the image enhancement. In fact, the limb is dark and uniform in color around the planet. The Voyager project is manages for NASA by the Jet Propulsion Laboratory.

  6. Deep Vein Thrombosis and True Crural Aneurysm: Misdiagnosis or Causal Relation?

    PubMed

    Floros, Nikolaos; Antoniou, Zoi; Papadakis, Marios

    2016-04-01

    True crural artery aneurysm is a rare clinical entity. Crural artery aneurysms are most frequently seen in men in their sixth decade without major cardiopulmonary diseases and are often associated with injury, superinfection, or vasculitis. We report the case of a 44-year-old man with a history of idiopathic deep vein thrombosis (DVT) as the first manifestation of a true crural artery aneurysm. To our knowledge, DVT is very rarely related with true crural artery aneurysms, with only 3 cases reported in the current literature. Open surgical repair is the most common management, with ligation as a second option in emergencies such as rupture. The related literature is discussed. We conclude that crural aneurysms should be considered in differential diagnosis of popliteal DVT in adults. True crural aneurysms need vigilance and a more systematical approach to provide physicians the means to the best medical care.

  7. Finnishing the Force: Achieving True Flexibility for the Joint Force Commander

    DTIC Science & Technology

    2014-06-01

    CREW) 2.1 vehicle-mounted jammer (up to 25,000 of which are on contract for purchase by the US Army). It uses a digitally controlled, 30-watt...out assigned tasks. We may no longer be able to afford the luxury of retaining our most sophisticated capabilities as or- ganic elements of a...joint force” (II-7). 2. “JCREW: ITT Wins Contracts for Land Mine Jammers,” Defense Industry Daily, 3 Octo- ber 2011, http://www.defenseindustrydaily.com

  8. Production of the Smallest QED Atom: True Muonium

    SciTech Connect

    Brodsky, Stanley J.; Lebed, Richard F.

    2009-04-15

    The 'true muonium' ({mu}{sup +}{mu}{sup -}) and 'true tauonium' ({tau}{sup +}{tau}{sup -}) bound states are not only the heaviest, but also the most compact pure QED systems. The rapid weak decay of the {tau} makes the observation of true tauonium difficult. However, as we show, the production and study of true muonium is possible at modern electron-positron colliders.

  9. Comparative Reliabilities of the Multiple Choice and True-False Formats.

    ERIC Educational Resources Information Center

    Oosterhof, Albert C.; Glasnapp, Douglas R.

    The present study was concerned with several currently unanswered questions, two of which are: what is an empirically determined ratio of multiple choice to equivalent true-false items which can be answered in a given amount of time?; and for achievement test items administered within a classroom situation, which of the two formats under…

  10. Determining true nursing costs improves financial planning.

    PubMed

    Payson, A A

    1987-05-01

    The traditional method of apportioning nursing care costs ona per diem basis does not consider nursing intensity or patients' special needs and often includes nonnursing duties. Many hospitals now favor a fee-for-service concept and are determining direct patient care costs to identify the true nursing cost. A patient classification system correlated with the diagnosis-related group (DRG) classification improves nursing cost analyses. For each patient, nurse managers need systems to determine quantified nursing tasks and patient acuity levels for each day. This information can be used to adjust staffing and to establish variable billing procedures. Then they can institute variable billing methods that are based on direct care costs as well as indirect costs of administration, education, and supplies. Variable billing identifies revenue cost centers, allows systematic monitoring of nursing services, and improves budget planning. The entire nursing staff must become involved in the financial system so the hospital can obtain an accurate data base for rate setting and third-party reimbursement.

  11. Model suggests Earth undergoing true polar wander

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2012-11-01

    At various points throughout Earth's history, the planet's solid exterior has drifted about in relation to the planetary rotation axis. This solid body drift, which is known as “true polar wander,” results in a wholesale shift in the orientation of Earth's landmasses and is different from the motion of individual tectonic plates (“tectonic drift”) or of the magnetic pole (“apparent polar wander”). Sorting out when, in which direction, and at what rate the Earth's solid exterior has rotated in this way depends on having a stable frame of reference to which observations of relative motion can be compared. To develop such a frame, researchers rely on hot spots, regions of recurrent volcanism that are known to produce long, largely linear island chains—such as the Hawaiian islands—as an overlying tectonic plate passes overhead. Hot spots are fed by magma plumes from the deep mantle and hence tend to be long-lived and relatively stable. Hot spots have long been used to understand the motion of tectonic plates.

  12. True color tube bore inspection system

    NASA Astrophysics Data System (ADS)

    Pechersky, Martin J.; Harpring, Larry J.

    2000-03-01

    A True Color Tube Bore Inspection System (TCTBIS) has been developed to aid in the visual nondestructive examination of the inside surfaces of small bore stainless steel tubes. The instrument was developed to inspect for the presence of contaminants and oxidation on the inner surfaces of these 1.5 to 1.7 millimeter inside diameter tubes. Previously a parameter called the color factor, which can be calculated from the images collected by the TCTBIS, was found to be a good measure of the surface quality in these tubes. The color factor is a global number in the sense that it is calculated for the entire inspection region. Additional algorithms have also been developed to evaluate the tube based on surface inhomogeneities that are indicative of the presence of foreign matter, local chemical attack or other undesirable but localized conditions. These algorithms have been incorporated into an up-to-date apparatus which is described in detail. We have also investigated the feasibility of using artificial intelligence techniques to aid in the interpretation of these defects. Promising results were obtained with a feed forward, back propagation artificial neural network.

  13. Placebo: the lie that comes true?

    PubMed

    Justman, Stewart

    2013-04-01

    Over the decades of experimentation on the placebo effect, it has become clear that it is driven largely by expectation, and that strong expectations of efficacy are more likely to give rise to the experience of benefit. No wonder the placebo effect has come to resemble a self-fulfilling prophecy. However, this resemblance is considerably exaggerated. The placebo effect does not work as strongly as it is advertised to do in some efforts to elicit it. Half-truths about the placebo effect are now in circulation, reinforced by a number of other equivocations that it seems to attract. As the deceptive use of placebos has fallen into discredit, the use of half-truths and exaggerations-neither of which is technically a deception-becomes an ever more inviting possibility. However, there are risks and costs associated with the half-truth that the doctor possesses the power to make his or her words come true by the alchemy of the placebo effect.

  14. True Color of Jupiter's Great Red Spot

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Roughly true color image of the Great Red Spot of Jupiter as taken by the Galileo imaging system on June 26, 1996. Because the Galileo imaging system's wavelength sensitivities go beyond those of the human eye, this is only an approximation of what a human observer would have seen in place of the Galileo spacecraft. To simulate red as our eyes see it, the near-infrared filter (756 nm) image was used. To simulate blue as our eyes see it, the violet filter (410 nm) image was used. Finally, to simulate green as our eyes see it, a combination of 2/3 violet and 1/3 near-infrared was used. The result is an image that is similar in color to that seen when looking through a telescope at Jupiter with your eye, but allowing detail about 100 times finer to be visible! The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC. This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at URL http://www.jpl.nasa.gov/galileo/sepo

  15. Nathan Watt: A True American Idol

    ERIC Educational Resources Information Center

    Watt, Diana

    2006-01-01

    In this article, the author profiles her son Nathan Watt, a 14-year-old who was born with Spina Bifida, who does not allow setbacks to keep him from achieving his goals and dreams in the areas of writing, recording, and performing his own music. He has also opened a business website and turned his story, "Anything is Possible," into a color story…

  16. Class Rank Weighs Down True Learning

    ERIC Educational Resources Information Center

    Guskey, Thomas R.

    2014-01-01

    The process of determining class rank does not help students achieve more or reach higher levels of proficiency. Evidence indicates ranking students may diminish students' motivation. High school educators argue that they are compelled to rank-order graduating students because selective colleges and universities require information about…

  17. Guilty, but not ashamed: "true" self-conceptions influence affective responses to personal shortcomings.

    PubMed

    Vess, Matthew; Schlegel, Rebecca J; Hicks, Joshua A; Arndt, Jamie

    2014-06-01

    The current research examined how true self-conceptions (who a person believes he or she truly is) influence negative self-relevant emotions in response to shortcomings. In Study 1 (N = 83), an Internet sample of adults completed a measure of authenticity, reflected on a shortcoming or positive life event, and completed state shame and guilt measures. In Study 2 (N = 49), undergraduates focused on true versus other determined self-attributes, received negative performance feedback, and completed state shame and guilt measures. In Study 3 (N = 138), undergraduates focused on self-determined versus other determined self-aspects, reflected on a shortcoming or neutral event, and completed state shame, guilt, and self-esteem measures. In Study 4 (N = 75), undergraduates thought about true self-attributes, an achievement, or an ordinary event; received positive or negative performance feedback; and completed state shame and guilt measures. In Study 1, differences in true self-expression positively predicted shame-free guilt (but not guilt-free shame) following reminders of a shortcoming. Studies 2-4 found that experimental activation of true self-conceptions increased shame-free guilt and generally decreased guilt-free shame in response to negative evaluative experiences. The findings offer novel insights into true self-conceptions by revealing their impact on negative self-conscious emotions.

  18. Identifying true satellites of the Magellanic Clouds

    NASA Astrophysics Data System (ADS)

    Sales, Laura V.; Navarro, Julio F.; Kallivayalil, Nitya; Frenk, Carlos S.

    2017-02-01

    The hierarchical nature of ΛCDM suggests that the Magellanic Clouds must have been surrounded by a number of satellites before their infall into the Milky Way halo. Many of those satellites should still be in close proximity to the Clouds, but some could have dispersed ahead/behind the Clouds along their Galactic orbit. Either way, prior association with the Clouds constrains the present-day positions and velocities of candidate Magellanic satellites: they must lie close to the nearly polar orbital plane of the Magellanic Stream, and their distances and radial velocities must follow the latitude dependence expected for a tidal stream with the Clouds near pericentre. We use a cosmological numerical simulation of the disruption of a massive sub-halo in a Milky Way-sized ΛCDM halo to test whether any of the 20 dwarfs recently discovered in the Dark Energy Survey, the Survey of the MAgellanic Stellar History, Pan-STARRS, and ATLAS surveys are truly associated with the Clouds. Of the six systems with kinematic data, only Hor 1 has distance and radial velocities consistent with a Magellanic origin. Of the remaining dwarfs, six (Hor 2, Eri 3, Ret 3, Tuc 4, Tuc 5, and Phx 2) have positions and distances consistent with a Magellanic origin, but kinematic data are needed to substantiate that possibility. Conclusive evidence for association would require proper motions to constrain the orbital angular momentum direction, which, for true Magellanic satellites, must be similar to that of the Clouds. We use this result to predict radial velocities and proper motions for all new dwarfs, assuming that they were Magellanic satellites. Our results are relatively insensitive to the assumption of first or second pericentre for the Clouds.

  19. In Search of the True Solar Twin

    NASA Astrophysics Data System (ADS)

    Dewarf, L. E.; Guinan, E. F.; Dituro, P.; Mittal, R.; Guedel, M.; Ribas, I.

    1998-12-01

    We present an aspect of our on-going program of "The Sun in Time" that deals with identifying and studying nearby stars that closely match the Sun in their physical properties. Generally a solar twin is defined to be a star with similar properties to the Sun - such as spectral type, color, Teff, M_v, Fe/H, etc. However, in the definition adopted by us for a true solar twin, we also require the star's age to be close (+/-1 Gyr) to the Sun's. When possible, the optically selected solar twin candidates are compared to the energy distributions and emission fluxes of the present Sun in the X-ray through NUV wavelength regions. These emissions from the Sun arise chiefly from magnetic-dynamo activity. The magnetic activity and related coronal X-ray and chromospheric emissions vary as function of the star's rotation period, and thus age. Therefore a star's age can be estimated from its levels of magnetic activity by using age-activity relations. At the present time, the star best matching the Sun in M_v, Teff, age, and chemical abundance [M/H] is 18 Sco (see Porto de Mello & Da Silva 1997, ApJ, 482, L89). Analysis of age-magnetic activity indicators such as L_x, CaII H+K and Mg II h+k indicate levels of magnetic activity closely matched to the Sun. These proxies of age indicate that 18 Sco to be rotating within a few days of the Sun's 25.5 day rotation period. Isochronal fits to the observed M_v and Teff were carried out and indicate an age of 4.8+/-0.8 Gyr with an inferred mass closely matched to the Sun, M=1.0+/-0.03 MSun. This research is supported by NSF/RUI Grant AST93-15365 and NASA Grant NAG5-2160 which we gratefully acknowledge.

  20. A Study of the Pre-Licensure Nursing Students' Perception of the Simulation Learning Environment as Helpful in Achieving Clinical Competencies and Their Perception of the Impact of the Level of Fidelity

    ERIC Educational Resources Information Center

    Crary, Wendy M.

    2012-01-01

    The research question of this study was: to what degree do nursing students perceive using the High Fidelity Simulation (HFS) learning environment to be helpful in their ability to achieve clinical competency. The research sub-questions (7) explored the students' demographics as an influence on rating of reality and helpfulness and the…

  1. [Endovascular coiling of a «true» posterior communicating artery aneurysm].

    PubMed

    Almeida-Pérez, Rafael; Espinosa-García, Héctor; Alcalá-Cerra, Gabriel; de la Rosa-Manjarréz, Ginna; Orozco-Gómez, Fernando

    2014-01-01

    True posterior communicating artery aneurysms originate exclusively from the wall of this artery and should be differentiated from aneurysms of the posterior communicating segment of the distal carotid artery. As these lesions are rare, their anatomical relationships have been poorly described; likewise, reports concerning their endovascular treatment are extremely rare and the technical aspects poorly detailed. A case of a patient with a true aneurysm of the left posterior communicating artery treated by endovascular coiling is presented. A literature review was also conducted to illustrate the anatomical and technical details relevant to achieving its successful treatment.

  2. Why several truths can be true

    PubMed Central

    Meland, Eivind; Brodersen, John

    2016-01-01

    In this paper, we offer a perspective on complementarity, acknowledging that it is not possible for human perception and cognition to grasp reality with unambiguous concepts or theories. Therefore, multiple concepts and perspectives are valid when they are not exaggerated beyond reasonable limits and do not claim exclusive validity. We recommend a humble stance enabling respectful dialogue between different perspectives in medical science and practice. Key Points No single perspective in clinical or scientific medicine can exhaustively explain medical phenomena.Scientific attitude is characterised by a willingness to look for objections against what we prefer as truths.Complementarity or unifying contradictions are concepts that allow for humility and pluralism in clinical and scientific medicine. PMID:27406215

  3. True beam commissioning experience at Nordland Hospital Trust, Norway

    NASA Astrophysics Data System (ADS)

    Daci, Lulzime; Malkaj, Partizan

    2016-03-01

    To evaluate the measured of all photon beam data of first Varian True Beam version 2.0 slim model, recently commissioned at Nordland Hospital Trust, Bodø. To compare and evaluate the possibility of beam matching with the Clinac2300, for the energies of 6MV and 15 MV. Materials/Methods: Measurements of PDD, OAR, and Output factors were realized with the IBA Blue-phantom with different detectors and evaluated between them for all photon energies: 6MV, 15MV, 6MV FFF and 10MV FFF. The ionization chambers used were Pin Point CC01, CC04, Semiflex CC13 and photon diode by Iba dosimetry. The data were processed using Beizer algorithm with a resolution of 1 mm. The measured depth dose curves, diagonals, OAR, and output factors were imported into Eclipse in order to calculate beam data for the anisotropic analytical algorithm (AAA version 10.0.28) for both the dataset measured with CC04 and CC13 and compared. The model head of 23EX was selected as the most near model to True Beam as a restriction of our version of Aria. It was seen that better results were achieved with the CC04 measured data as a result of better resolution. For the biggest field after 10 cm depth a larger difference is seen between measured and calculated for both dataset, but it is within the criteria for acceptance. Results: The Beam analysis criteria of 2 mm at 50% dose is achieved for all the fields accept for 40x40 that is within 3%. Depth difference at maximum dose is within 1 mm for all the fields and dose difference at 100 mm and 200 mm is lower than 1% for or all the fields. The PDD between two machines for all the fields differ after Dmax with less than 1%. For profiles in the field zone and outside field the difference is within 1% for all the fields. In the penumbra region the difference is from 2% up to 12% for big fields. As for diagonals they differ as a result of the head construction at the edge of the field and the penumbra region. The output factors differ for big fields within 5% and

  4. Dynamic 1.5-T vs 3-T true fast imaging with steady-state precession (trueFISP)-MRI sequences for assessment of velopharyngeal function

    PubMed Central

    Sinko, K; Czerny, C; Jagsch, R; Baumann, A

    2015-01-01

    Objectives: To compare the image quality of MRI scans produced with 1.5- and 3.0-T devices during functional test condition. Methods: 65 MRI scans obtained with 1.5- (n = 43) or 3.0-T (n = 22) true fast imaging with steady-state precession (trueFISP) sequences from patients with a history of a cleft palate were evaluated. Two experts assessed the MRI scans, independently of each other, and blinded to the MRI technique used. Subjective ratings were entered on a five-point Likert scale. The median planes of three anatomical structures (velum, tongue and pharyngeal wall) were assessed in three functional states (at rest, during phonation of sustained “e” and during articulation of “kkk”). In addition, MRI scans taken during velopharyngeal closure were evaluated. Results: Under blinded conditions, both observers (radiologist and orthodontist) independently rated the quality of 1.5-T scans higher than that of 3.0 T. Statistical analysis of pooled data showed that the differences were highly significant (p < 0.009) in 4 out of 10 test conditions. The greatest differences in favour of 1.5 T were observed for MRI scans of the velum. Conclusions: 1.5 T used with trueFISP may be preferable over 3.0-T trueFISP for the evaluation of the velopharyngeal structures in the clinical routine. PMID:26090932

  5. FPGA Implementation of Metastability-Based True Random Number Generator

    NASA Astrophysics Data System (ADS)

    Hata, Hisashi; Ichikawa, Shuichi

    True random number generators (TRNGs) are important as a basis for computer security. Though there are some TRNGs composed of analog circuit, the use of digital circuits is desired for the application of TRNGs to logic LSIs. Some of the digital TRNGs utilize jitter in free-running ring oscillators as a source of entropy, which consume large power. Another type of TRNG exploits the metastability of a latch to generate entropy. Although this kind of TRNG has been mostly implemented with full-custom LSI technology, this study presents an implementation based on common FPGA technology. Our TRNG is comprised of logic gates only, and can be integrated in any kind of logic LSI. The RS latch in our TRNG is implemented as a hard-macro to guarantee the quality of randomness by minimizing the signal skew and load imbalance of internal nodes. To improve the quality and throughput, the output of 64-256 latches are XOR'ed. The derived design was verified on a Xilinx Virtex-4 FPGA (XC4VFX20), and passed NIST statistical test suite without post-processing. Our TRNG with 256 latches occupies 580 slices, while achieving 12.5Mbps throughput.

  6. Non-syndromic occurrence of true generalized microdontia with mandibular mesiodens - a rare case

    PubMed Central

    2011-01-01

    Abnormalities in size of teeth and number of teeth are occasionally recorded in clinical cases. True generalized microdontia is rare case in which all the teeth are smaller than normal. Mesiodens is commonly located in maxilary central incisor region and uncommon in the mandible. In the present case a 12 year-old boy was healthy; normal in appearance and the medical history was noncontributory. The patient was examined and found to have permanent teeth that were smaller than those of the average adult teeth. The true generalized microdontia was accompanied by mandibular mesiodens. This is a unique case report of non-syndromic association of mandibular hyperdontia with true generalized microdontia. PMID:22035324

  7. Measuring true localization accuracy in super resolution microscopy with DNA-origami nanostructures

    NASA Astrophysics Data System (ADS)

    Reuss, Matthias; Fördős, Ferenc; Blom, Hans; Öktem, Ozan; Högberg, Björn; Brismar, Hjalmar

    2017-02-01

    A common method to assess the performance of (super resolution) microscopes is to use the localization precision of emitters as an estimate for the achieved resolution. Naturally, this is widely used in super resolution methods based on single molecule stochastic switching. This concept suffers from the fact that it is hard to calibrate measures against a real sample (a phantom), because true absolute positions of emitters are almost always unknown. For this reason, resolution estimates are potentially biased in an image since one is blind to true position accuracy, i.e. deviation in position measurement from true positions. We have solved this issue by imaging nanorods fabricated with DNA-origami. The nanorods used are designed to have emitters attached at each end in a well-defined and highly conserved distance. These structures are widely used to gauge localization precision. Here, we additionally determined the true achievable localization accuracy and compared this figure of merit to localization precision values for two common super resolution microscope methods STED and STORM.

  8. Material Properties Test to Determine Ultimate Strain and True Stress-True Strain Curves for High Yield Steels

    SciTech Connect

    K.R. Arpin; T.F. Trimble

    2003-04-01

    This testing was undertaken to develop material true stress-true strain curves for elastic-plastic material behavior for use in performing transient analysis. Based on the conclusions of this test, the true stress-true strain curves derived herein are valid for use in elastic-plastic finite element analysis for structures fabricated from these materials. In addition, for the materials tested herein, the ultimate strain values are greater than those values cited as the limits for the elastic-plastic strain acceptance criteria for transient analysis.

  9. [Neurological Signs and Symptoms of True Neurogenic Thoracic Outlet Syndrome].

    PubMed

    Higashihara, Mana; Konoeda, Fumie; Sonoo, Masahiro

    2016-05-01

    Thoracic outlet syndrome (TOS) is a well-known disorder, but many aspects of its pathology, including its definition, has been disputed. True neurogenic TOS (TN-TOS) is a rare but well-defined clinical condition. TN-TOS results from the compression of the C8/T1 roots (dominant for the T1 root) or the proximal lower trunk of the brachial plexus by a fibrous band. The band extends from the first rib to either the tip of an elongated C7 transverse process or a rudimentary cervical rib. The most common presenting symptoms of TN-TOS are insidious-onset atrophy and weakness of the intrinsic hand muscles, predominantly in the thenar eminence and radial digit flexors. Nerve conduction studies demonstrate pathognomonic findings: severely attenuated compound muscle action potential of the abductor pollicis brevis muscle, and usually, loss of the sensory nerve action potential of the medial antebrachial cutaneous nerve. Numbness and sensory loss are typically observed, mainly in the medial forearm, although they are usually mild, and may be absent in some patients. Severe pain or paresthesia proximal to the elbow is not observed. The classical concept of TOS underlie nonspecific neurogenic TOS. It has been primarily diagnosed using provocative maneuvers. However, there is controversy regarding its pathological conceptualization and existence, as objective evidence of the disease is still lacking.

  10. Microstructural analysis of pineal volume using trueFISP imaging

    PubMed Central

    Bumb, Jan M; Brockmann, Marc A; Groden, Christoph; Nolte, Ingo

    2013-01-01

    AIM: To determine the spectrum of pineal microstructures (solid/cystic parts) in a large clinical population using a high-resolution 3D-T2-weighted sequence. METHODS: A total of 347 patients enrolled for cranial magnetic resonance imaging were randomly included in this study. Written informed consent was obtained from all patients. The exclusion criteria were artifacts or mass lesions prohibiting evaluation of the pineal gland in any of the sequences. True-FISP-3D-imaging (1.5-T, isotropic voxel 0.9 mm) was performed in 347 adults (55.4 ± 18.1 years). Pineal gland volume (PGV), cystic volume, and parenchyma volume (cysts excluded) were measured manually. RESULTS: Overall, 40.3% of pineal glands were cystic. The median PGV was 54.6 mm3 (78.33 ± 89.0 mm3), the median cystic volume was 5.4 mm3 (15.8 ± 37.2 mm3), and the median parenchyma volume was 53.6 mm3 (71.9 ± 66.7 mm3). In cystic glands, the standard deviation of the PGV was substantially higher than in solid glands (98% vs 58% of the mean). PGV declined with age (r = -0.130, P = 0.016). CONCLUSION: The high interindividual volume variation is mainly related to cysts. Pineal parenchyma volume decreased slightly with age, whereas gender-related effects appear to be negligible. PMID:23671752

  11. True-sky demonstration of an autonomous star tracker

    NASA Astrophysics Data System (ADS)

    van Bezooijen, Roelof W.

    1994-07-01

    An autonomous star tracker (AST) is basically a `star field in, attitude out' device capable of determining its attitude without requiring any a priori attitude knowledge. In addition to this attitude acquisition capability, an AST can perform attitude updates autonomously and is able to provide its attitude `continuously' while tracking a star field. The Lockheed Palo Alto Research Laboratory is developing a reliable, low-cost, miniature AST that has a one arcsec overall accuracy, weighs less than 1.5 kg, consumes less than 7 watts of power, and is sufficiently sensitive to be used at all sky locations. The device performs attitude acquisition in a fraction of a second and outputs its attitude at a 10 Hz rate when operating in its tracking mode. Besides providing the functionality needed for future advanced attitude control and navigation systems, an AST also improves spacecraft reliability, mass, power, cost, and operating expenses. The AST comprises a-thermalized, refractive optics, a frame-transfer CCD with a sensitive area of 1024 by 1024 pixels, camera electronics implemented with application- specific integrated circuits, a compact single board computer with a radiation hard 32 bit RISC processor, and an all-sky guide star database. Star identification is performed by a memory- efficient and highly robust algorithm that finds the largest group of observed stars matching a group of guide stars. An important milestone has recently been achieved with the validation of the attitude acquisition capability through correct and rapid identification of all 704 true-sky star fields obtained at the Lick Observatory, using an uncalibrated prototype AST with a 512 by 1024 pixel frame-transfer CCD and a 50 mm f/1.2 lens that provided an effective 6.5 by 13.2 degree field of view. The overlapping fields cover 47% of the sky, including both rich and sparse areas. The paper contains a description of the AST, a summary of the functions enabled or improved by the device, an

  12. Comparing recollective experience in true and false autobiographical memories.

    PubMed

    Heaps, C M; Nash, M

    2001-07-01

    This study investigated whether true autobiographical memories are qualitatively distinct from false autobiographical memories using a variation of the interview method originally reported by E. F. Loftus and J. Pickrell (1995). Participants recalled events provided by parents on 3 separate occasions and were asked to imagine true and false unremembered events. True memories were rated by both participants and observers as more rich in recollective experience and were rated by participants as more important, more emotionally intense, as having clearer imagery, and as less typical than false memories. Rehearsal frequency was used as a covariate, eliminating these effects. Imagery in true memories was most often viewed from the field perspective, whereas imagery in false memories was most often viewed from the observer perspective. More information was communicated in true memories, and true memories contained more information concerning the consequences of described events. Results suggest repeated remembering can make false memories more rich in recollective experience and more like true memories. Differences between true and false memories suggest some potentially distinct characteristics of false memories and provide insight into the process of false memory creation.

  13. Adults' Memories of Childhood: True and False Reports

    ERIC Educational Resources Information Center

    Qin, Jianjian; Ogle, Christin M.; Goodman, Gail S.

    2008-01-01

    In 3 experiments, the authors examined factors that, according to the source-monitoring framework, might influence false memory formation and true/false memory discernment. In Experiment 1, combined effects of warning and visualization on false childhood memory formation were examined, as were individual differences in true and false childhood…

  14. True and False Memories, Parietal Cortex, and Confidence Judgments

    ERIC Educational Resources Information Center

    Urgolites, Zhisen J.; Smith, Christine N.; Squire, Larry R.

    2015-01-01

    Recent studies have asked whether activity in the medial temporal lobe (MTL) and the neocortex can distinguish true memory from false memory. A frequent complication has been that the confidence associated with correct memory judgments (true memory) is typically higher than the confidence associated with incorrect memory judgments (false memory).…

  15. Estimating the Reliability of Multiple True-False Tests.

    ERIC Educational Resources Information Center

    Frisbie, David A.; Druva, Cynthia A.

    1986-01-01

    This study was designed to examine the level of dependence within multiple true-false test-item clusters by computing sets of item correlations with data from a test composed of both multiple true-false and multiple-choice items. (Author/LMO)

  16. Discovering a "True" Map of the World--Learning Activities.

    ERIC Educational Resources Information Center

    Hantula, James

    "True" maps of the world, as seen from the perspective of the time in which they were produced, remain an ethnocentric visual language in modern times. Students can gain insight into such "true" maps by studying maps produced in the great traditions of the West and East. Teachers can determine a map's appropriateness by identifying its title,…

  17. True bug (Heteroptera) impact on cocoa fruit mortality and productivity.

    PubMed

    Yede; Babin, R; Djieto-Lordon, C; Cilas, C; Dibog, L; Mahob, R; Bilong, C F Bilong

    2012-08-01

    The real impact of true bug damage on cocoa pods has never been assessed precisely. We conducted a 2-yr study on 1,080 cocoa trees on 36 farms in Cameroon to assess the contribution of true bugs to fruit mortality and production loss. The cocoa fruiting cycle, fruit mortality, and damage caused by true bugs as well as other pests and diseases were monitored on a weekly basis. True bug damage also was described on 2,500 ripe pods per year. Pod weight, bean number, and bean weight were measured and compared for different degrees and types of damage on the ripe pods. Our results showed that true bugs were the main external cause of young fruit abortion. They reduced the abundance of young fruit by up to 10%. In contrast, although one-third of the ripe pods sampled had true bug lesions, only 4% were moderately to heavily damaged. The mean weight of ripe pods was reduced by 12% when there was medium to heavy damage. While the mean weight of wet beans was reduced significantly (by 3-10%), the number of beans per pod was not changed by damage. Despite the reduction in mean weight, the overall weight of beans for the pods sampled was reduced by <2%. Therefore, our study confirmed the common assumption that the economic impact of true bug damage on mature pods is negligible on cocoa farms in Cameroon. However, true bugs have a significant impact on young fruit mortality.

  18. Low high-density lipoprotein cholesterol is a residual risk factor associated with long-term clinical outcomes in diabetic patients with stable coronary artery disease who achieve optimal control of low-density lipoprotein cholesterol.

    PubMed

    Ogita, Manabu; Miyauchi, Katsumi; Miyazaki, Tadashi; Naito, Ryo; Konishi, Hirokazu; Tsuboi, Shuta; Dohi, Tomotaka; Kasai, Takatoshi; Yokoyama, Takayuki; Okazaki, Shinya; Kurata, Takeshi; Daida, Hiroyuki

    2014-01-01

    Diabetes mellitus is recognized an independent risk factor for coronary artery disease (CAD) and mortality. Clinical trials have shown that statins significantly reduce cardiovascular events in diabetic patients. However, residual cardiovascular risk persists despite the achievement of target low-density lipoprotein cholesterol (LDL-C) levels with statin. High-density lipoprotein cholesterol (HDL-C) is an established coronary risk factor that is independent of LDL-C levels. We evaluated the impact of HDL-C on long-term mortality in diabetic patients with stable CAD who achieved optimal LDL-C. We enrolled 438 consecutive diabetic patients who were scheduled for percutaneous coronary intervention between 2004 and 2007 at our institution. We identified 165 patients who achieved target LDL-C <100 mg/dl. Patients were stratified into two groups according to HDL-C levels (low HDL-C group, baseline HDL-C <40 mg/dl; high HDL-C group, ≥40 mg/dl). Major adverse cardiac events (MACE) that included all-cause death, acute coronary syndrome, and target lesion revascularization were evaluated between the two groups. The median follow-up period was 946 days. The rate of MACE was significantly higher in diabetic patients with low-HDL-C who achieved optimal LDL-C (6.9 vs 17.9 %, log-rank P = 0.030). Multivariate Cox regression analysis showed that HDL-C is significantly associated with clinical outcomes (adjusted hazard ratio for MACE 1.33, 95 % confidence interval 1.01-1.75, P = 0.042). Low HDL-C is a residual risk factor that is significantly associated with long-term clinical outcomes among diabetic patients with stable CAD who achieve optimal LDL-C levels.

  19. True color blood flow imaging using a high-speed laser photography system

    NASA Astrophysics Data System (ADS)

    Liu, Chien-Sheng; Lin, Cheng-Hsien; Sun, Yung-Nien; Ho, Chung-Liang; Hsu, Chung-Chi

    2012-10-01

    Physiological changes in the retinal vasculature are commonly indicative of such disorders as diabetic retinopathy, glaucoma, and age-related macular degeneration. Thus, various methods have been developed for noninvasive clinical evaluation of ocular hemodynamics. However, to the best of our knowledge, current ophthalmic instruments do not provide a true color blood flow imaging capability. Accordingly, we propose a new method for the true color imaging of blood flow using a high-speed pulsed laser photography system. In the proposed approach, monochromatic images of the blood flow are acquired using a system of three cameras and three color lasers (red, green, and blue). A high-quality true color image of the blood flow is obtained by assembling the monochromatic images by means of image realignment and color calibration processes. The effectiveness of the proposed approach is demonstrated by imaging the flow of mouse blood within a microfluidic channel device. The experimental results confirm the proposed system provides a high-quality true color blood flow imaging capability, and therefore has potential for noninvasive clinical evaluation of ocular hemodynamics.

  20. A Human Achievement: Mathematics without Boundaries.

    ERIC Educational Resources Information Center

    Terzioglu, Tosun

    This paper describes three fundamental principles, dictated by Wilhelm von Humboldt, that were widely adapted as the basic philosophy of higher education in the United States, and proposes to revise the unfulfilled dream of von Humboldt to make it come true. This paper stresses the achievements of humanity not only in technology, health, or the…

  1. Verification of dosimetric accuracy on the TrueBeam STx: Rounded leaf effect of the high definition MLC

    SciTech Connect

    Kielar, Kayla N.; Mok, Ed; Hsu, Annie; Wang Lei; Luxton, Gary

    2012-10-15

    Purpose: The dosimetric leaf gap (DLG) in the Varian Eclipse treatment planning system is determined during commissioning and is used to model the effect of the rounded leaf-end of the multileaf collimator (MLC). This parameter attempts to model the physical difference between the radiation and light field and account for inherent leakage between leaf tips. With the increased use of single fraction high dose treatments requiring larger monitor units comes an enhanced concern in the accuracy of leakage calculations, as it accounts for much of the patient dose. This study serves to verify the dosimetric accuracy of the algorithm used to model the rounded leaf effect for the TrueBeam STx, and describes a methodology for determining best-practice parameter values, given the novel capabilities of the linear accelerator such as flattening filter free (FFF) treatments and a high definition MLC (HDMLC). Methods: During commissioning, the nominal MLC position was verified and the DLG parameter was determined using MLC-defined field sizes and moving gap tests, as is common in clinical testing. Treatment plans were created, and the DLG was optimized to achieve less than 1% difference between measured and calculated dose. The DLG value found was tested on treatment plans for all energies (6 MV, 10 MV, 15 MV, 6 MV FFF, 10 MV FFF) and modalities (3D conventional, IMRT, conformal arc, VMAT) available on the TrueBeam STx. Results: The DLG parameter found during the initial MLC testing did not match the leaf gap modeling parameter that provided the most accurate dose delivery in clinical treatment plans. Using the physical leaf gap size as the DLG for the HDMLC can lead to 5% differences in measured and calculated doses. Conclusions: Separate optimization of the DLG parameter using end-to-end tests must be performed to ensure dosimetric accuracy in the modeling of the rounded leaf ends for the Eclipse treatment planning system. The difference in leaf gap modeling versus physical

  2. Past and present achievements, and future direction of the Gastrointestinal Oncology Study Group (GIOSG), a Division of Japan Clinical Oncology Group (JCOG).

    PubMed

    Boku, Narikazu

    2011-12-01

    Initially, Gastrointestinal Study Group in Japan Clinical Oncology Group (GIOSG/JCOG) focused on gastric cancer. In 1980s, fluoropyrimidine, cisplatin and mitomycin C were key drugs. A randomized Phase II trial (JCOG8501) comparing futrafur plus mitomycin C and uracil plus futrafur and mitomycin C showed a higher response rate of uracil plus futrafur and mitomycin C than futrafur plus mitomycin C. From the results of two Phase II trials of etoposide, adriamycin and cisplatin, and cisplatin plus 5-fluorouracil, uracil plus futrafur and mitomycin C and cisplatin plus 5-fluorouracil were adopted for the test arms of the Phase III trial (JCOG9205) comparing with continuous infusion of 5-fluorouracil as a control arm. Neither cisplatin plus 5-fluorouracil nor uracil plus futrafur and mitomycin C showed a survival benefit over continuous infusion of 5-fluorouracil. In late 1990s, new agents, irinotecan and S-1, were developed for gastric cancer in Japan. GIOSG conducted a Phase III trial (JCOG9912) investigating superiority of irinotecan plus cisplatin and non-inferiority of monotherapy with S-1 compared with continuous infusion of 5-fluorouracil, and S-1 succeeded in showing non-inferiority. Then, SPIRITS trial showed a survival benefit of S-1 plus cisplatin over S-1, resulting in the establishment of a standard care for advanced gastric cancer in Japan. GIOSG have merged with Gastric Cancer Study Group as the Stomach Cancer Study Group (SCSG) from 2011. Recent progress in the development of new drugs has been remarkable. From the point of the roles shared with many other study groups for clinical trials, including registration trials of new drugs conducted by pharmaceutical companies, SCSG should recognize its role and conduct clinical trials with high quality for establishing new standard treatment.

  3. Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.

    PubMed

    Martinez-Outschoorn, Ubaldo E; Prisco, Marco; Ertel, Adam; Tsirigos, Aristotelis; Lin, Zhao; Pavlides, Stephanos; Wang, Chengwang; Flomenberg, Neal; Knudsen, Erik S; Howell, Anthony; Pestell, Richard G; Sotgia, Federica; Lisanti, Michael P

    2011-04-15

    Previously, we showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor cell behavior, here we used genome-wide transcriptional profiling. Briefly, human breast cancer cells (MCF7) were cultured with lactate or ketones, and then subjected to transcriptional analysis (exon-array). Interestingly, our results show that treatment with these high-energy metabolites increases the transcriptional expression of gene profiles normally associated with "stemness," including genes upregulated in embryonic stem (ES) cells. Similarly, we observe that lactate and ketones promote the growth of bonafide ES cells, providing functional validation. The lactate- and ketone-induced "gene signatures" were able to predict poor clinical outcome (including recurrence and metastasis) in a cohort of human breast cancer patients. Taken together, our results are consistent with the idea that lactate and ketone utilization in cancer cells promotes the "cancer stem cell" phenotype, resulting in significant decreases in patient survival. One possible mechanism by which these high-energy metabolites might induce stemness is by increasing the pool of Acetyl-CoA, leading to increased histone acetylation, and elevated gene expression. Thus, our results mechanistically imply that clinical outcome in breast cancer could simply be determined by epigenetics and energy metabolism, rather than by the accumulation of specific "classical" gene mutations. We also suggest that high-risk cancer patients (identified by the lactate/ketone gene signatures) could be treated with new therapeutics that target oxidative mitochondrial metabolism, such as the anti-oxidant and "mitochondrial poison" metformin. Finally, we propose that this new approach to personalized cancer medicine be termed

  4. Broadband true time delay for microwave signal processing, using slow light based on stimulated Brillouin scattering in optical fibers.

    PubMed

    Chin, Sanghoon; Thévenaz, Luc; Sancho, Juan; Sales, Salvador; Capmany, José; Berger, Perrine; Bourderionnet, Jérôme; Dolfi, Daniel

    2010-10-11

    We experimentally demonstrate a novel technique to process broadband microwave signals, using all-optically tunable true time delay in optical fibers. The configuration to achieve true time delay basically consists of two main stages: photonic RF phase shifter and slow light, based on stimulated Brillouin scattering in fibers. Dispersion properties of fibers are controlled, separately at optical carrier frequency and in the vicinity of microwave signal bandwidth. This way time delay induced within the signal bandwidth can be manipulated to correctly act as true time delay with a proper phase compensation introduced to the optical carrier. We completely analyzed the generated true time delay as a promising solution to feed phased array antenna for radar systems and to develop dynamically reconfigurable microwave photonic filters.

  5. All the Vice Chancellor’s Neuroscientists: Unity to Achieve Success in Solving Malaysia’s Diseases via Upgrading Clinical Services and Neuroscience Research

    PubMed Central

    Abdullah, Jafri Malin

    2013-01-01

    President Obama of the United States of America announced this April the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN for short) investment, while Professor Henry Markram’s team based in the European Union will spend over a billion euros on the Human Brain Project, breaking through the unknowns in the fifth science of the decade: Neuroscience. Malaysia's growth in the same field needs to be augmented, and thus the Universiti Sains Malaysia’s vision is to excel in the field of clinical brain sciences, mind sciences and neurosciences. This will naturally bring up the level of research in the country simultaneously. Thus, a center was recently established to coordinate this venture. The four-year Integrated Neuroscience Program established recently will be a sustainable source of neuroscientists for the country. We hope to establish ourselves by 2020 as a global university with neurosciences research as an important flagship. PMID:23966818

  6. Nonperturbative True Muonium on the Light Front with TMSWIFT

    NASA Astrophysics Data System (ADS)

    Lamm, Henry; Lebed, Richard F.

    2016-08-01

    The true muonium {(μbar{μ})} bound state presents an interesting test of light-cone quantization techniques. In addition to exhibiting the standard problems of handling non-perturbative calculations, true muonium requires correct treatment of {ebar{e}} Fock-state contributions. Having previously produced a crude model of true muonium using the method of iterated resolvents, our current work has focused on the inclusion of the box diagrams to improve the cutoff-dependent issues of the model. Further, a parallel computer code, TMSWIFT, allowing for smaller numerical uncertainties, has been developed. This work focuses on the current state of these efforts to develop a model of true muonium that is testable at near-term experiments.

  7. True and false memories, parietal cortex, and confidence judgments.

    PubMed

    Urgolites, Zhisen J; Smith, Christine N; Squire, Larry R

    2015-11-01

    Recent studies have asked whether activity in the medial temporal lobe (MTL) and the neocortex can distinguish true memory from false memory. A frequent complication has been that the confidence associated with correct memory judgments (true memory) is typically higher than the confidence associated with incorrect memory judgments (false memory). Accordingly, it has often been difficult to know whether a finding is related to memory confidence or memory accuracy. In the current study, participants made recognition memory judgments with confidence ratings in response to previously studied scenes and novel scenes. The left hippocampus and 16 other brain regions distinguished true and false memories when confidence ratings were different for the two conditions. Only three regions (all in the parietal cortex) distinguished true and false memories when confidence ratings were equated. These findings illustrate the utility of taking confidence ratings into account when identifying brain regions associated with true and false memories. Neural correlates of true and false memories are most easily interpreted when confidence ratings are similar for the two kinds of memories.

  8. Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis.

    PubMed

    Carson, Christine F; Smith, David W; Lampacher, Gail J; Riley, Thomas V

    2008-01-01

    Double-blinding is an important and widely implemented feature of clinical trials although its success is rarely assessed. In a randomized, placebo-controlled trial of tea tree oil, an aromatic essential oil, for the treatment of recurrent herpes labialis (RHL), or cold sores, deception was used to prevent volunteers from identifying their treatment allocation. Volunteers received placebo (n=102) or tea tree oil (n=112) ointment in preparation for their next episode of RHL and were told, falsely, that the aroma of the ointments had been changed to prevent identification of the treatment group. At the trial's end, of the volunteers who had used their ointment and presented for treatment assessment (n=100), approximately 50% correctly guessed their treatment allocation (P=0.774). Amongst volunteers that had not presented for treatment assessment (n=114), 12 volunteers did not provide blinding data and 46 did not open their tube. For the 56 volunteers who opened their tube, less than half of those receiving tea tree oil (44.4%) and only a small proportion of those on placebo (17.2%) were able to correctly identify their treatment allocation. Among the volunteers that were not treated, the P-value was 0.083. This study showed that the ethical use of deception may provide effective blinding in challenging circumstances.

  9. Implant-supported overdenture manufactured using CAD/CAM techniques to achieve horizontal path insertion between the primary and secondary structure: A clinical case report

    PubMed Central

    Agustín-Panadero, Rubén; Peñarrocha-Oltra, David; Gomar-Vercher, Sonia; Ferreiroa, Alberto

    2015-01-01

    This report describes the case of an edentulous patient with an atrophic maxilla and severe class III malocclusion. Prosthetic rehabilitation was performed using CAD/CAM techniques for manufacturing an implant-supported overdenture with horizontal insertion. A vestibulo-lingual insertion overdenture is a precision prosthesis with a fixation system affording a good fit between the primary and secondary structure. Both structures exhibit passive horizontal adjustment. This treatment option requires the same number of implants as implant-supported fixed dentures. The horizontal assembly system prevents the prosthesis from loosening or moving in response to axial and non-axial forces. The technique was used to rehabilitate a patient presenting an atrophic upper maxilla, with the insertion of 8 implants. No complications were reported at follow-up 3, 6 and 12 months after fitting of the prosthesis. This system offers solutions to the clinical and laboratory complications associated with hybrid prostheses, concealing emergence of the chimneys and improving implant-prosthesis hygiene. PMID:26140179

  10. SU-E-T-327: The Update of a XML Composing Tool for TrueBeam Developer Mode

    SciTech Connect

    Yan, Y; Mao, W; Jiang, S

    2014-06-01

    Purpose: To introduce a major upgrade of a novel XML beam composing tool to scientists and engineers who strive to translate certain capabilities of TrueBeam Developer Mode to future clinical benefits of radiation therapy. Methods: TrueBeam Developer Mode provides the users with a test bed for unconventional plans utilizing certain unique features not accessible at the clinical mode. To access the full set of capabilities, a XML beam definition file accommodating all parameters including kV/MV imaging triggers in the plan can be locally loaded at this mode, however it is difficult and laborious to compose one in a text editor. In this study, a stand-along interactive XML beam composing application, TrueBeam TeachMod, was developed on Windows platforms to assist users in making their unique plans in a WYSWYG manner. A conventional plan can be imported in a DICOM RT object as the start of the beam editing process in which trajectories of all axes of a TrueBeam machine can be modified to the intended values at any control point. TeachMod also includes libraries of predefined imaging and treatment procedures to further expedite the process. Results: The TeachMod application is a major of the TeachMod module within DICOManTX. It fully supports TrueBeam 2.0. Trajectories of all axes including all MLC leaves can be graphically rendered and edited as needed. The time for XML beam composing has been reduced to a negligible amount regardless the complexity of the plan. A good understanding of XML language and TrueBeam schema is not required though preferred. Conclusion: Creating XML beams manually in a text editor will be a lengthy error-prone process for sophisticated plans. A XML beam composing tool is highly desirable for R and D activities. It will bridge the gap between scopes of TrueBeam capabilities and their clinical application potentials.

  11. Lay denial of knowledge for justified true beliefs.

    PubMed

    Nagel, Jennifer; Juan, Valerie San; Mar, Raymond A

    2013-12-01

    Intuitively, there is a difference between knowledge and mere belief. Contemporary philosophical work on the nature of this difference has focused on scenarios known as "Gettier cases." Designed as counterexamples to the classical theory that knowledge is justified true belief, these cases feature agents who arrive at true beliefs in ways which seem reasonable or justified, while nevertheless seeming to lack knowledge. Prior empirical investigation of these cases has raised questions about whether lay people generally share philosophers' intuitions about these cases, or whether lay intuitions vary depending on individual factors (e.g. ethnicity) or factors related to specific types of Gettier cases (e.g. cases that include apparent evidence). We report an experiment on lay attributions of knowledge and justification for a wide range of Gettier Cases and for a related class of controversial cases known as Skeptical Pressure cases, which are also thought by philosophers to elicit intuitive denials of knowledge. Although participants rated true beliefs in Gettier and Skeptical Pressure cases as being justified, they were significantly less likely to attribute knowledge for these cases than for matched True Belief cases. This pattern of response was consistent across different variations of Gettier cases and did not vary by ethnicity or gender, although attributions of justification were found to be positively related to measures of empathy. These findings therefore suggest that across demographic groups, laypeople share similar epistemic concepts with philosophers, recognizing a difference between knowledge and justified true belief.

  12. Graded Achievement, Tested Achievement, and Validity

    ERIC Educational Resources Information Center

    Brookhart, Susan M.

    2015-01-01

    Twenty-eight studies of grades, over a century, were reviewed using the argument-based approach to validity suggested by Kane as a theoretical framework. The review draws conclusions about the meaning of graded achievement, its relation to tested achievement, and changes in the construct of graded achievement over time. "Graded…

  13. Blocking Mimicry Makes True and False Smiles Look the Same

    PubMed Central

    Rychlowska, Magdalena; Cañadas, Elena; Wood, Adrienne; Krumhuber, Eva G.; Fischer, Agneta; Niedenthal, Paula M.

    2014-01-01

    Recent research suggests that facial mimicry underlies accurate interpretation of subtle facial expressions. In three experiments, we manipulated mimicry and tested its role in judgments of the genuineness of true and false smiles. Experiment 1 used facial EMG to show that a new mouthguard technique for blocking mimicry modifies both the amount and the time course of facial reactions. In Experiments 2 and 3, participants rated true and false smiles either while wearing mouthguards or when allowed to freely mimic the smiles with or without additional distraction, namely holding a squeeze ball or wearing a finger-cuff heart rate monitor. Results showed that blocking mimicry compromised the decoding of true and false smiles such that they were judged as equally genuine. Together the experiments highlight the role of facial mimicry in judging subtle meanings of facial expressions. PMID:24670316

  14. Determination of the true density of pulverized coal samples

    USGS Publications Warehouse

    Stanton, R.W.

    1982-01-01

    A method using the gas-comparison pycnometer with helium gas as the penetrating medium measures precisely the true volume of a pulverized coal sample. The true density of a solid is calculated as the true unit volume of the solid exclusive of its pore space which is divided into the weight of the sample. The method is similar to that used to determine the density of refractory materials but the procedure is modified to yield precise density determinations of coal samples. These modifications diminish effects of trapped moisture and gases on the volume measurement. The helium gas-comparison pycnometer method is rapid, reliable, precise, and requires minimal analytical equipment and sample preparation, and also is non-destructive to the coal sample. Using this method, densities can be determined on coal samples of subbituminous to low-volatile bituminous rank and perhaps also on samples of lignite. The density of anthracite samples has not been determined by this method.

  15. Evolution of deceptive and true courtship songs in moths.

    PubMed

    Nakano, Ryo; Takanashi, Takuma; Surlykke, Annemarie; Skals, Niels; Ishikawa, Yukio

    2013-01-01

    Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female moths of the Asian corn borer are unable to distinguish between the male courtship song and bat calls. Females react to both the male song and bat calls by "freezing", which males take advantage of in mating (deceptive courtship song). In contrast, females of the Japanese lichen moth are able to distinguish between the male song and bat calls by the structure of the sounds; females emit warning clicks against bats, but accept males (true courtship song). Here, we propose a hypothesis that deceptive and true signals evolved independently from slightly different precursory sounds; deceptive/true courtship songs in moths evolved from the sounds males incidentally emitted in a sexual context, which females could not/could distinguish, respectively, from bat calls.

  16. Evolution of deceptive and true courtship songs in moths

    PubMed Central

    Nakano, Ryo; Takanashi, Takuma; Surlykke, Annemarie; Skals, Niels; Ishikawa, Yukio

    2013-01-01

    Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female moths of the Asian corn borer are unable to distinguish between the male courtship song and bat calls. Females react to both the male song and bat calls by “freezing”, which males take advantage of in mating (deceptive courtship song). In contrast, females of the Japanese lichen moth are able to distinguish between the male song and bat calls by the structure of the sounds; females emit warning clicks against bats, but accept males (true courtship song). Here, we propose a hypothesis that deceptive and true signals evolved independently from slightly different precursory sounds; deceptive/true courtship songs in moths evolved from the sounds males incidentally emitted in a sexual context, which females could not/could distinguish, respectively, from bat calls. PMID:23788180

  17. High-speed time-reversed ultrasonically encoded (TRUE) optical focusing inside dynamic scattering media at 793 nm

    NASA Astrophysics Data System (ADS)

    Liu, Yan; Lai, Puxiang; Ma, Cheng; Xu, Xiao; Suzuki, Yuta; Grabar, Alexander A.; Wang, Lihong V.

    2014-03-01

    Time-reversed ultrasonically encoded (TRUE) optical focusing is an emerging technique that focuses light deep into scattering media by phase-conjugating ultrasonically encoded diffuse light. In previous work, the speed of TRUE focusing was limited to no faster than 1 Hz by the response time of the photorefractive phase conjugate mirror, or the data acquisition and streaming speed of the digital camera; photorefractive-crystal-based TRUE focusing was also limited to the visible spectral range. These time-consuming schemes prevent this technique from being applied in vivo, since living biological tissue has a speckle decorrelation time on the order of a millisecond. In this work, using a Tedoped Sn2P2S6 photorefractive crystal at a near-infrared wavelength of 793 nm, we achieved TRUE focusing inside dynamic scattering media having a speckle decorrelation time as short as 7.7 ms. As the achieved speed approaches the tissue decorrelation rate, this work is an important step forward toward in vivo applications of TRUE focusing in deep tissue imaging, photodynamic therapy, and optical manipulation.

  18. Software for determining the true displacement of faults

    NASA Astrophysics Data System (ADS)

    Nieto-Fuentes, R.; Nieto-Samaniego, Á. F.; Xu, S.-S.; Alaniz-Álvarez, S. A.

    2014-03-01

    One of the most important parameters of faults is the true (or net) displacement, which is measured by restoring two originally adjacent points, called “piercing points”, to their original positions. This measurement is not typically applicable because it is rare to observe piercing points in natural outcrops. Much more common is the measurement of the apparent displacement of a marker. Methods to calculate the true displacement of faults using descriptive geometry, trigonometry or vector algebra are common in the literature, and most of them solve a specific situation from a large amount of possible combinations of the fault parameters. True displacements are not routinely calculated because it is a tedious and tiring task, despite their importance and the relatively simple methodology. We believe that the solution is to develop software capable of performing this work. In a previous publication, our research group proposed a method to calculate the true displacement of faults by solving most combinations of fault parameters using simple trigonometric equations. The purpose of this contribution is to present a computer program for calculating the true displacement of faults. The input data are the dip of the fault; the pitch angles of the markers, slickenlines and observation lines; and the marker separation. To prevent the common difficulties involved in switching between operative systems, the software is developed using the Java programing language. The computer program could be used as a tool in education and will also be useful for the calculation of the true fault displacement in geological and engineering works. The application resolves the cases with known direction of net slip, which commonly is assumed parallel to the slickenlines. This assumption is not always valid and must be used with caution, because the slickenlines are formed during a step of the incremental displacement on the fault surface, whereas the net slip is related to the finite slip.

  19. Mood-congruent true and false memory: effects of depression.

    PubMed

    Howe, Mark L; Malone, Catherine

    2011-02-01

    The Deese/Roediger-McDermott paradigm was used to investigate the effect of depression on true and false recognition. In this experiment true and false recognition was examined across positive, neutral, negative, and depression-relevant lists for individuals with and without a diagnosis of major depressive disorder. Results showed that participants with major depressive disorder falsely recognised significantly more depression-relevant words than non-depressed controls. These findings also parallel recent research using recall instead of recognition and show that there are clear mood congruence effects for depression on false memory performance.

  20. Coal preparation process using true-heavy-liquid separation

    SciTech Connect

    Baltich, L.K.; Malhotra, D.

    1990-12-20

    The Pittsburgh Energy Technology Center (PETC) is supporting work to develop advanced fine-coal cleaning processes including the exploitation of differences in specific gravity through the use of heavy-liquid media in hydrocyclones. The true-heavy-liquid media used for this program are solutions of sulfuric acid (H{sub 2}SO{sub 4}) and water. This concept takes advantage of the miscibility of the acid water to produce a range of heavy liquids up to a specific gravity of 1.84 for pure sulfuric acid. The main objective of this research program was to develop a true-heavy-liquid separation process to clean ultrafine coal using smelter-guide sulfuric acid. Three bituminous coals and one subbituminous coal were selected for testing. In general, single-stage true-heavy-liquid hydrocyclone process demonstrated similar performance characteristics to heavy-media separation processes under study by other investigators. True-heavy-liquid media has the advantage of allowing additional separation steps at other specific gravities for cleaning and scavenging without the introduction of another heavy liquid to the flowsheet. In addition, sulfuric acid is inorganic and can be neutralized and disposed of without the toxicity problems associated with the other type of heavy liquids under consideration. Preliminary economics analysis indicates that the cost for sulfuric acid makeup to the process may be prohibitive. 4 refs., 11 figs., 61 tabs.

  1. Estimating true color imagery for GOES-R

    NASA Astrophysics Data System (ADS)

    Grossberg, Michael D.; Shahriar, Fazlul; Gladkova, Irina; Alabi, Paul K.; Hillger, Donald W.; Miller, Steven D.

    2011-06-01

    The Advanced Baseline Imager (ABI) on GOES-R will help NOAA's objective of engaging and educating the public on environmental issues by providing near real-time imagery of the earth-atmosphere system. True color satellite images are beneficial to the public, as well as to scientists, who use these images as an important "decision aid" and visualization tool. Unfortunately, ABI only has two visible bands (cyan and red) and does not directly produce the three bands (blue, green, and red) used to create true color imagery. We have developed an algorithm that will produce quantitative true color imagery from ABI. Our algorithm estimates the three tristimulus values of the international standard CIE 1931 XYZ colorspace for each pixel of the ABI image, and thus is compatible with a wide range of software packages and hardware devices. Our algorithm is based on a non-linear statistical regression framework that incorporate both classification and local multispectral regression using training data. We have used training data from the hyper-spectral imager Hyperion. Our algorithm to produce true color images from the ABI is not specific to ABI and may be applicable to other satellites which, like the ABI, do not have the ability to directly produce RGB imagery.

  2. The Full and True Value of Campus Heritage

    ERIC Educational Resources Information Center

    Elefante, Carl

    2011-01-01

    To gain a full and true understanding of the value of campus heritage requires shifting perspective. On many campuses, heritage resources are perceived to have no relevance whatsoever to the challenges of sustainability. This results largely from a profound misconception about what may constitute a sustainable future and what steps may be needed…

  3. Neural correlates underlying true and false associative memories.

    PubMed

    Dennis, Nancy A; Johnson, Christina E; Peterson, Kristina M

    2014-07-01

    Despite the fact that associative memory studies produce a large number of false memories, neuroimaging analyses utilizing this paradigm typically focus only on neural activity mediating successful retrieval. The current study sought to expand on this prior research by examining the neural basis of both true and false associative memories. Though associative false memories are substantially different than those found in semantic or perceptual false memory paradigms, results suggest that associative false memories are mediated by similar neural mechanisms. Specifically, we found increased frontal activity that likely represents enhanced monitoring and evaluation compared to that needed for true memories and correct rejections. Results also indicated that true, and not false associative memories, are mediated by neural activity in the MTL, specifically the hippocampus. Finally, while activity in early visual cortex distinguished true from false memories, a lack of neural differences between hits and correct rejections failed to support previous findings suggesting that activity in early visual cortex represents sensory reactivation of encoding-related processing.

  4. Will true 3d display devices aid geologic interpretation. [Mirage

    SciTech Connect

    Nelson, H.R. Jr.

    1982-04-01

    A description is given of true 3D display devices and techniques that are being evaluated in various research laboratories around the world. These advances are closely tied to the expected application of 3D display devices as interpretational tools for explorationists. 34 refs.

  5. My True Voice: Fundamental Content, Individual Capability, Social Progress

    ERIC Educational Resources Information Center

    Shirer, Natalie Baker

    2005-01-01

    This article examines the "My True Voice Project," a mentorship-based program that uses principles of theater education to teach students effective oral communication skills. This project offers a unique model for how arts education can teach children vital thinking skills, strengthen traditional skills, and build community. As such, the…

  6. Activation of Imaginal Information on True and False Memories

    ERIC Educational Resources Information Center

    Chang, Sau Hou; Pierce, Benton H.

    2009-01-01

    The present study examined the activation of imaginal information on true and false memories. Participants studied a series of concrete objects in pictures or words. The imagery group (n = 96) was instructed to form images and the control group (n = 96) was not instructed to do so. Both groups were then given a standard recognition memory test and…

  7. Using Story Contexts to Bias Children's True and False Memories

    ERIC Educational Resources Information Center

    Howe, Mark L.; Wilkinson, Samantha

    2011-01-01

    The effects of embedding standard Deese/Roediger-McDermott (DRM) lists into stories whose context biased interpretation either toward or away from the overall themes of the DRM lists on both true and false recognition were investigated with 7- and 11-year-olds. These biased story contexts were compared with the same children's susceptibility to…

  8. Remaining True to the Vision: Promoting Research in FCS

    ERIC Educational Resources Information Center

    Blackwell, Ann P.; Burgess, Anne M.

    2006-01-01

    There is an ongoing need for family and consumer sciences professionals to generate new knowledge through research and then share findings with diverse groups. Specific Action Steps describe methods to incorporate research into university curricula to promote this role. The ultimate goal is to inspire new professionals to remain true to the…

  9. Meaningful Movement for Children: Stay True to Their Natures

    ERIC Educational Resources Information Center

    Baumgarten, Sam

    2006-01-01

    This article discusses the meaningful movement for children. In this article, the author discusses "roots" in the "physical education garden" which, when thoroughly examined, reveal tried and true insights about children and their natures. By revisiting these natures or characteristics, one will have a clearer picture of what is meaningful to…

  10. Escape from true stent jail by use of the rotablator.

    PubMed

    Mushahwar, S S; Ramsdale, D R

    2000-02-01

    We describe the use of the Rotablator device to allow sidebranch access via the side-wall of a stent when it has proved impossible to pass even the lowest profile balloon catheter through the struts N a situation of "true stent jail".

  11. Educators' Ability to Detect True and False Bullying Statements

    ERIC Educational Resources Information Center

    Gomez-Garibello, Carlos; Saykaly, Christine; Moore, Kelsey; Talwar, Victoria

    2013-01-01

    The majority of research investigating children's lie-telling behavior has focused on lay people and legal professionals' abilities to detect deception. Fewer researchers have assessed educators' abilities to evaluate the veracity of children's reports of bullying. In this study, educators' abilities to detect true and false accounts of bullying…

  12. Phylogeny and historical biogeography of the true morels (Morchella)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    True morels (Morchella) are among the most charismatic of all edible macrofungi. Contributing to their allure is their short and sporadic fruiting season during the spring. Most species are distributed in temperate forests of the northern hemisphere, which suggests that they evolved in Laurasia. ...

  13. Molecular characterization of true morels (Morchella) in Turkey

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A collection of 247 true morels (Morchella spp.) was made from 10 different provinces of Turkey during the 2007-2008 growing season. This collection was analyzed for species diversity using phylogenetic analyses of partial Ribonucleic acid (RNA) polymerase I (RPB1) and nuclear ribosomal large subuni...

  14. True or False: Do 5-Year-Olds Understand Belief?

    ERIC Educational Resources Information Center

    Fabricius, William V.; Boyer, Ty W.; Weimer, Amy A.; Carroll, Kathleen

    2010-01-01

    In 3 studies (N = 188) we tested the hypothesis that children use a perceptual access approach to reason about mental states before they understand beliefs. The perceptual access hypothesis predicts a U-shaped developmental pattern of performance in true belief tasks, in which 3-year-olds who reason about reality should succeed, 4- to 5-year-olds…

  15. Neural correlates of true and false belief reasoning.

    PubMed

    Sommer, Monika; Döhnel, Katrin; Sodian, Beate; Meinhardt, Jörg; Thoermer, Claudia; Hajak, Göran

    2007-04-15

    Belief reasoning plays a central role in making inferences about other people's mental states. The ability to reason about false beliefs is considered as a critical test for having a Theory of Mind (ToM). There is some controversy as to whether it is the medial prefrontal cortex (MPFC) or the temporo-parietal junction (TPJ) that is centrally involved in belief reasoning. According to developmental studies of belief reasoning we conducted an fMRI experiment with a carefully controlled paradigm (Sally Anne scenario). We compared false belief reasoning with true belief reasoning in parallel tasks, using a series of cartoon stories depicting transfer of an object unbeknownst to the protagonist (false belief) or with the protagonist witnessing (true belief). The false belief versus true belief contrast revealed activation of the dorsal part of the anterior cingulate cortex (dACC), the right lateral rostral prefrontal cortex and the right TPJ associated with false belief. We suggest that the activation of the dACC and the lateral PFC might be associated with action monitoring and stimulus-independent cognitive processing whereas the activation of the TPJ might be related to the computation of mental representations that create perspective differences, such as a person's false belief that contrasts with reality and therefore might be centrally involved in the decoupling mechanism. Additionally we found common patterns of activation for true and false belief reasoning, including inferior parietal and precuneus activation, but we found no activation of the MPFC or the TPJ in general belief reasoning.

  16. True Triaxial Stresses and the Brittle Fracture of Rock

    NASA Astrophysics Data System (ADS)

    Haimson, Bezalel

    2006-06-01

    This paper reviews the efforts made in the last 100 years to characterize the effect of the intermediate principal stress σ 2 on brittle fracture of rocks, and on their strength criteria. The most common theories of failure in geomechanics, such as those of Coulomb, and Mohr, disregard σ 2 and are typically based on triaxial testing of cylindrical rock samples subjected to equal minimum and intermediate principal stresses (σ 3=σ 2). However, as early as 1915 Böker conducted conventional triaxial extension tests (σ 1=σ 2) on the same Carrara marble tested earlier in conventional triaxial compression by von Kármán that showed a different strength behavior. Efforts to incorporate the effect of σ 2 on rock strength continued in the second half of the last century through the work of Nadai, Drucker and Prager, Murrell, Handin, Wiebols and Cook, and others. In 1971 Mogi designed a high-capacity true triaxial testing machine, and was the first to obtain complete true triaxial strength criteria for several rocks based on experimental data. Following his pioneering work, several other laboratories developed equipment and conducted true triaxial tests revealing the extent of σ 2 effect on rock strength (e.g., Takahashi and Koide, Michelis, Smart, Wawersik). Testing equipment emulating Mogi's but considerably more compact was developed at the University of Wisconsin and used for true triaxial testing of some very strong crystalline rocks. Test results revealed three distinct compressive failure mechanisms, depending on loading mode and rock type: shear faulting resulting from extensile microcrack localization, multiple splitting along the σ 1 axis, and nondilatant shear failure. The true triaxial strength criterion for the KTB amphibolite derived from such tests was used in conjunction with logged breakout dimensions to estimate the maximum horizontal in situ stress in the KTB ultra deep scientific hole.

  17. Stratification of pseudoprogression and true progression of glioblastoma multiform based on longitudinal diffusion tensor imaging without segmentation

    PubMed Central

    Qian, Xiaohua; Tan, Hua; Zhang, Jian; Zhao, Weilin; Chan, Michael D.; Zhou, Xiaobo

    2016-01-01

    Purpose: Pseudoprogression (PsP) can mimic true tumor progression (TTP) on magnetic resonance imaging in patients with glioblastoma multiform (GBM). The phenotypical similarity between PsP and TTP makes it a challenging task for physicians to distinguish these entities. So far, no approved biomarkers or computer-aided diagnosis systems have been used clinically for this purpose. Methods: To address this challenge, the authors developed an objective classification system for PsP and TTP based on longitudinal diffusion tensor imaging. A novel spatio-temporal discriminative dictionary learning scheme was proposed to differentiate PsP and TTP, thereby avoiding segmentation of the region of interest. The authors constructed a novel discriminative sparse matrix with the classification-oriented dictionary learning approach by excluding the shared features of two categories, so that the pooled features captured the subtle difference between PsP and TTP. The most discriminating features were then identified from the pooled features by their feature scoring system. Finally, the authors stratified patients with GBM into PsP and TTP by a support vector machine approach. Tenfold cross-validation (CV) and the area under the receiver operating characteristic (AUC) were used to assess the robustness of the developed system. Results: The average accuracy and AUC values after ten rounds of tenfold CV were 0.867 and 0.92, respectively. The authors also assessed the effects of different methods and factors (such as data types, pooling techniques, and dimensionality reduction approaches) on the performance of their classification system which obtained the best performance. Conclusions: The proposed objective classification system without segmentation achieved a desirable and reliable performance in differentiating PsP from TTP. Thus, the developed approach is expected to advance the clinical research and diagnosis of PsP and TTP. PMID:27806598

  18. Using Administrative Data to Ascertain True Cases of Muscular Dystrophy: Rare Disease Surveillance

    PubMed Central

    2017-01-01

    Background Administrative records from insurance and hospital discharge data sources are important public health tools to conduct passive surveillance of disease in populations. Identifying rare but catastrophic conditions is a challenge since approaches for maximizing valid case detection are not firmly established. Objective The purpose of our study was to explore a number of algorithms in which International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes and other administrative variables could be used to identify cases of muscular dystrophy (MD). Methods We used active surveillance to identify possible cases of MD in medical practices in neurology, genetics, and orthopedics in 5 urban South Carolina counties and to identify the cases that had diagnostic support (ie, true cases). We then developed an algorithm to identify cases based on a combination of ICD-9-CM codes and administrative variables from a public (Medicaid) and private insurer claims-based system and a statewide hospital discharge dataset (passive surveillance). Cases of all types of MD and those with Duchenne or Becker MD (DBMD) that were common to both surveillance systems were examined to identify the most specific administrative variables for ascertainment of true cases. Results Passive statewide surveillance identified 3235 possible cases with MD in the state, and active surveillance identified 2057 possible cases in 5 actively surveilled counties that included 2 large metropolitan areas where many people seek medical care. There were 537 common cases found in both the active and passive systems, and 260 (48.4%) were confirmed by active surveillance to be true cases. Of the 260 confirmed cases, 70 (26.9%) were recorded as DBMD. Conclusions Accuracy of finding a true case in a passive surveillance system was improved substantially when specific diagnosis codes, number of times a code was used, age of the patient, and specialty provider variables were used

  19. ID-Check: Online Concealed Information Test Reveals True Identity.

    PubMed

    Verschuere, Bruno; Kleinberg, Bennett

    2016-01-01

    The Internet has already changed people's lives considerably and is likely to drastically change forensic research. We developed a web-based test to reveal concealed autobiographical information. Initial studies identified a number of conditions that affect diagnostic efficiency. By combining these moderators, this study investigated the full potential of the online ID-check. Participants (n = 101) tried to hide their identity and claimed a false identity in a reaction time-based Concealed Information Test. Half of the participants were presented with personal details (e.g., first name, last name, birthday), whereas the others only saw irrelevant details. Results showed that participants' true identity could be detected with high accuracy (AUC = 0.98; overall accuracy: 86-94%). Online memory detection can reliably and validly detect whether someone is hiding their true identity. This suggests that online memory detection might become a valuable tool for forensic applications.

  20. Commercialized VCSEL components fabricated at TrueLight Corporation

    NASA Astrophysics Data System (ADS)

    Pan, Jin-Shan; Lin, Yung-Sen; Li, Chao-Fang A.; Chang, C. H.; Wu, Jack; Lee, Bor-Lin; Chuang, Y. H.; Tu, S. L.; Wu, Calvin; Huang, Kai-Feng

    2001-05-01

    TrueLight Corporation was found in 1997 and it is the pioneer of VCSEL components supplier in Taiwan. We specialize in the production and distribution of VCSEL (Vertical Cavity Surface Emitting Laser) and other high-speed PIN-detector devices and components. Our core technology is developed to meet blooming demand of fiber optic transmission. Our intention is to diverse the device application into data communication, telecommunication and industrial markets. One mission is to provide the high performance, highly reliable and low-cost VCSEL components for data communication and sensing applications. For the past three years, TrueLight Corporation has entered successfully into the Gigabit Ethernet and the Fiber Channel data communication area. In this paper, we will focus on the fabrication of VCSEL components. We will present you the evolution of implanted and oxide-confined VCSEL process, device characterization, also performance in Gigabit data communication and the most important reliability issue

  1. Analog time-reversed ultrasonically encoded (TRUE) optical focusing inside scattering media with high power gain (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Ma, Cheng; Xu, Xiao; Wang, Lihong V.

    2016-03-01

    Focusing light deep inside scattering media plays a key role in such biomedical applications as high resolution optical imaging, control, and therapy. In recent years, wavefront shaping technologies have come a long way in controlling light propagation in complex media. A prominent example is time-reversed ultrasonically encoded (TRUE) focusing, which allows noninvasive introduction of "guide stars" inside biological tissue to guide light focusing. By measuring the optical wavefront emanating from an ultrasound focus created at the target location, TRUE determines the desired wavefront non-iteratively, and achieves focusing at the target position via a subsequent optical time reversal. Compared to digital counterparts that employ slow electronic spatial light modulators and cameras, analog TRUE focusing relies on nonlinear photorefractive crystals that inherently accommodate more spatial modes and eliminate the troublesome alignment and data transfer required by digital approaches. However, analog TRUE focusing suffers from its small gain, defined as the energy or power ratio between the focusing and probing beams in the focal volume. Here, by implementing a modified analog TRUE focusing scheme that squeezes the duration of the time-reversed photon packet below the carrier-recombination-limited hologram decay time of the crystal, we demonstrated a photon flux amplification much greater than unity at a preset focal voxel in between two scattering layers. Although the energy gain was still below unity, the unprecedented power gain will nevertheless benefit new biomedical applications.

  2. Wing motion measurement and aerodynamics of hovering true hoverflies.

    PubMed

    Mou, Xiao Lei; Liu, Yan Peng; Sun, Mao

    2011-09-01

    Most hovering insects flap their wings in a horizontal plane (body having a large angle from the horizontal), called `normal hovering'. But some of the best hoverers, e.g. true hoverflies, hover with an inclined stroke plane (body being approximately horizontal). In the present paper, wing and body kinematics of four freely hovering true hoverflies were measured using three-dimensional high-speed video. The measured wing kinematics was used in a Navier-Stokes solver to compute the aerodynamic forces of the insects. The stroke amplitude of the hoverflies was relatively small, ranging from 65 to 85 deg, compared with that of normal hovering. The angle of attack in the downstroke (∼50 deg) was much larger that in the upstroke (∼20 deg), unlike normal-hovering insects, whose downstroke and upstroke angles of attack are not very different. The major part of the weight-supporting force (approximately 86%) was produced in the downstroke and it was contributed by both the lift and the drag of the wing, unlike the normal-hovering case in which the weight-supporting force is approximately equally contributed by the two half-strokes and the lift principle is mainly used to produce the force. The mass-specific power was 38.59-46.3 and 27.5-35.4 W kg(-1) in the cases of 0 and 100% elastic energy storage, respectively. Comparisons with previously published results of a normal-hovering true hoverfly and with results obtained by artificially making the insects' stroke planes horizontal show that for the true hoverflies, the power requirement for inclined stroke-plane hover is only a little (<10%) larger than that of normal hovering.

  3. Axes determination for segmented true-coaxial HPGe detectors

    NASA Astrophysics Data System (ADS)

    Abt, I.; Caldwell, A.; Liu, J.; Majorovits, B.; Petrov, P.; Volynets, O.

    2012-03-01

    A fast method to determine the crystallographic axes of segmented true-coaxial high-purity germanium detectors is presented. It is based on the analysis of segment-occupancy patterns obtained by irradiation with radioactive sources. The measured patterns are compared to predictions for different axes orientations. The predictions require a simulation of the trajectories of the charge carriers taking the transverse anisotropy of their drift into account.

  4. True bugs (Hemiptera, Heteroptera) as psyllid predators (Hemiptera, Psylloidea)

    PubMed Central

    Jerinić-Prodanović, Dušanka; Protić, Ljiljana

    2013-01-01

    Abstract Data on natural enemies of psyllids are rare and can usually be found in papers about economically significant species. During an investigation of psyllid fauna in Serbia, natural enemies were investigated, too. True bugs were the most numerous among them. From 28 psyllid species, 21 species of true bugs from families Anthocoridae and Miridae were reared. Seven species of Anthocoridae were identified: Anthocoris amplicollis (Horváth, 1839), Anthocoris confusus Reuter, 1884, Anthocoris nemoralis (Fabricius, 1794), Anthocoris nemorum (Linnaeus, 1761), Orius majusculus Reuter, 1884, Orius minutus (Linnaeus, 1758) and Orius niger Wolff, 1811. The following 14 species of Miridae were identified: Atractotomus mali Meyer-Dür, 1843, Campylomma verbasci (Meyer-Dür, 1843), Deraeocoris flavilinea (A. Costa, 1862), Deraeocoris ruber (Linnaeus, 1758), Deraeocoris lutescens (Schilling, 1836), Heterocordylus genistae (Scopoli, 1763), Hypseloecus visci (Puton, 1888), Malacocoris chlorizans Panzer, 1794, Miris striatus (Linnaeus, 1758), Orthotylus marginalis Reuter, 1884, Psallus assimilis Stichel, 1956, Psallus quercus Kirschbaum, 1856, Psallus flavellus Stichel, 1933 and Pseudoloxops coccinea (Meyer-Dür, 1843). The aim of the research was to provide list of true bugs recorded as predators of psyllids in order to preserve their diversity and significance, especially on cultivated plants. PMID:24003311

  5. Leader as achiever.

    PubMed

    Dienemann, Jacqueline

    2002-01-01

    This article examines one outcome of leadership: productive achievement. Without achievement one is judged to not truly be a leader. Thus, the ideal leader must be a visionary, a critical thinker, an expert, a communicator, a mentor, and an achiever of organizational goals. This article explores the organizational context that supports achievement, measures of quality nursing care, fiscal accountability, leadership development, rewards and punishments, and the educational content and teaching strategies to prepare graduates to be achievers.

  6. A Pilot Study on Culottes versus Crossover Single Stenting for True Coronary Bifurcation Lesions

    PubMed Central

    Zhang, Linlin; Zhong, Wenliang; Luo, Yukun; Chen, Lianglong

    2016-01-01

    Background The purpose of our study was to compare clinical and angiographic outcomes of planned culottes technique with that of provisional crossover single stenting in the treatment of true coronary bifurcation lesions (CBL) with drug-eluting stent (DES). Methods True CBL patients (n = 104) were randomly assigned to either the provisional stenting of the side branch (crossover group) or the culottes group. Additional side branch (SB) stenting in the crossover group was required if there was thrombolysis in myocardial infarction flow ≤ 1 flow). The primary end point was the occurrence of major adverse cardiac events (MACE) at nine months, including cardiac death, myocardial infarction, target lesion/vessel revascularization and in-stent thrombosis. The secondary end point was angiographic in-segment restenosis at nine months. Results The rate of MACE at nine months was similar between the crossover and culottes groups (7.7% vs. 7.7%, p = 1.000). Additional SB stenting in the crossover group was required in 3.8% of patients. There was one procedural occlusion of SB in the crossover group. At nine months, the rate of in-segment restenosis was similar in the parent main vessel (0% vs. 1.9%, p = 1.000), main branch (1.9% vs. 7.7%, p = 0.363) and SB (17.3% vs. 9.6%, p = 0.250) between the crossover and culottes groups, respectively. Conclusions This study demonstrated that there is no significant difference in cumulative MACE or in-segment restenosis between crossover and culottes groups. Larger randomized clinical trials are warranted to re-evaluate the outcomes of the provisional crossover stenting versus the culottes stenting techniques utilizing DES for true CBL. PMID:27471358

  7. Method of achieving ultra-wideband true-time-delay beam steering for active electronically scanned arrays

    SciTech Connect

    Loui, Hung; Brock, Billy C.

    2016-10-25

    The various embodiments presented herein relate to beam steering an array antenna by modifying intermediate frequency (IF) waveforms prior to conversion to RF signals. For each channel, a direct digital synthesis (DDS) component can be utilized to generate a waveform or modify amplitude, timing and phase of a waveform relative to another waveform, whereby the generation/modification can be performed prior to the IF input port of a mixer on each channel. A local oscillator (LO) signal can be utilized to commonly drive each of the mixers. After conversion at the RF output port of each of the mixers, each RF signal can be transmitted by a respective antenna element in the antenna array. Initiation of transmission of each RF signal can be performed simultaneously at each antenna. The process can be reversed during receive whereby timing, amplitude, and phase of the received can be modified digitally post ADC conversion.

  8. 'Your true and proper gender': the Barr body as a good enough science of sex.

    PubMed

    Miller, Fiona Alice

    2006-09-01

    In the late 1940s, a microanatomist from London Ontario, Murray Barr, discovered a mark of sex chromosome status in bodily tissues, what came to be known as the 'Barr body'. This discovery offered an important diagnostic technology to the burgeoning clinical science community engaged with the medical interpretation and management of sexual anomalies. It seemed to offer a way to identify the true, underlying sex in those whose bodies or lives were sexually anomalous (intersexuals, homosexuals and transsexuals). The hypothesis that allowed the Barr body to stand in for 'chromosomal' or 'genetic' sex was provisional, but it supported the expectation that genetic information established one's primary identity, and the conviction that the animal world could be neatly divided into two, and only two, sexes. Ultimately, this provisional hypothesis, and its status as an unambiguous arbiter of true sex, was overturned. But during much of the 1950s, Barr's thesis about the identity of the Barr body was consistent with a coherent set of theories and evidence explaining sexual development and sexual pathology. Though provisional, the scientific status of the sex chromatin within this system of knowledge was good enough to support a flourishing research enterprise in the clinical sciences.

  9. Production of the smallest QED atom: true microonium (micro+micro-).

    PubMed

    Brodsky, Stanley J; Lebed, Richard F

    2009-05-29

    The "true microonium" (micro+micro-) and "true tauonium" (tau+tau-) bound states are not only the heaviest, but also the most compact pure QED systems. The rapid weak decay of the tau makes the observation of true tauonium difficult. However, as we show, the production and study of true microonium is possible at modern electron-positron colliders.

  10. Distinguishing true from false positives in genomic studies: p values.

    PubMed

    Broer, Linda; Lill, Christina M; Schuur, Maaike; Amin, Najaf; Roehr, Johannes T; Bertram, Lars; Ioannidis, John P A; van Duijn, Cornelia M

    2013-02-01

    Distinguishing true from false positive findings is a major challenge in human genetic epidemiology. Several strategies have been devised to facilitate this, including the positive predictive value (PPV) and a set of epidemiological criteria, known as the "Venice" criteria. The PPV measures the probability of a true association, given a statistically significant finding, while the Venice criteria grade the credibility based on the amount of evidence, consistency of replication and protection from bias. A vast majority of journals use significance thresholds to identify the true positive findings. We studied the effect of p value thresholds on the PPV and used the PPV and Venice criteria to define usable thresholds of statistical significance. Theoretical and empirical analyses of data published on AlzGene show that at a nominal p value threshold of 0.05 most "positive" findings will turn out to be false if the prior probability of association is below 0.10 even if the statistical power of the study is higher than 0.80. However, in underpowered studies (0.25) with a low prior probability of 1 × 10(-3), a p value of 1 × 10(-5) yields a high PPV (>96 %). Here we have shown that the p value threshold of 1 × 10(-5) gives a very strong evidence of association in almost all studies. However, in the case of a very high prior probability of association (0.50) a p value threshold of 0.05 may be sufficient, while for studies with very low prior probability of association (1 × 10(-4); genome-wide association studies for instance) 1 × 10(-7) may serve as a useful threshold to declare significance.

  11. A novel kind of programmable 3(n) feed-forward optical fiber true delay line based on SOA.

    PubMed

    Li, Xinwan; Peng, Limei; Wang, Songbo; Kim, Young-Chon; Chen, Jianping

    2007-12-10

    A new kind of 3(n) feed-forward programmable optical fiber true delay line was proposed. Theoretical analysis was presented on its delay performance and expandability. Experimental demonstration was given to show the implementation of such delay lines using SOAs and Farady rotation mirrors. Delay step as small as 0.5 ps with precision of about 0.03 ps was achieved. Measurement was performed to verify the feasibility and results are given.

  12. True polyandry and pseudopolyandry: why does a monandrous fly remate?

    PubMed Central

    2013-01-01

    Background The rate of female remating can have important impacts on a species, from affecting conflict and cooperation within families, to population viability and gene flow. However, determining the level of polyandry in a species can be difficult, with information on the mating system of many species being based on a single experiment, or completely absent. Here we investigate the mating system of the fruit fly Drosophila subobscura. Reports from England, Spain and Canada suggest D. subobscura is entirely monandrous, with no females remating. However, work in Greece suggests that 23% of females remate. We examine the willingness of female D. subobscura to remate in the laboratory in a range of conditions, using flies from both Greece and England. We make a distinction between pseudopolyandry, where a female remates after an ineffective first mating that is incapable of fertilising her eggs, and true polyandry, where a female remates even though she has received suitable sperm from a previous mating. Results We find a low rate of true polyandry by females (4%), with no difference between populations. The rate of true polyandry is affected by temperature, but not starvation. Pseudopolyandry is three times as common as true polyandry, and most females showing pseudopolyandry mated at their first opportunity after their first failed mating. However, despite the lack of differences in polyandry between the populations, we do find differences in the way males respond to exposure to other males prior to mating. In line with previous work, English flies responded to one or more rivals by increasing their copulation duration, a response previously thought to be driven by sperm competition. Greek males only show increased copulation duration when exposed to four or more rival males. This suggests that the response to rivals in D. subobscura is not related to sperm competition, because sperm competition is rare, and there is no correlation of response to rivals and mating

  13. Opportunity Approaches the Bowl of Beagle Crater (True Color)

    NASA Technical Reports Server (NTRS)

    2006-01-01

    NASA's Mars Exploration Rover Opportunity took this approximate true-color image of Beagle Crater from a distance of about 25 meters (82 feet). The crater is thought to be relatively young based on its prominent, raised rim and surrounding ejecta that have not been eroded away or buried by sand. The image also shows a portion of the eastern interior rim of Beagle Crater, which appears composed of jumbled, angular blocks of brighter and darker outcrop rocks. The rover will drive to the rim of the crater and acquire an extensive color panorama in the coming sols.

  14. Ternary jitter-based true random number generator

    NASA Astrophysics Data System (ADS)

    Latypov, Rustam; Stolov, Evgeni

    2017-01-01

    In this paper a novel family of generators producing true uniform random numbers in ternary logic is presented. The generator consists of a number of identical ternary logic combinational units connected into a ring. All the units are provided to have a random delay time, and this time is supposed to be distributed in accordance with an exponential distribution. All delays are supposed to be independent events. The theory of the generator is based on Erlang equations. The generator can be used for test production in various systems. Features of multidimensional random vectors, produced by the generator, are discussed.

  15. Heat-related illnesses. When are they a true emergency?

    PubMed

    Scott, J

    1989-06-01

    During the hot, humid months of summer, heat-related illnesses are common. Many of these are minor and self-limited, but heatstroke is a true emergency because the body's cooling mechanisms have been overwhelmed. The condition must be recognized rapidly and treated immediately with fluid replacement and cooling. The most effective and accessible technique for cooling involves the use of cool mist and fans directed across the patient's body to promote rapid evaporation. With aggressive management, the effects of heatstroke are almost uniformly reversible. With proper precautions, its occurrence is universally preventable.

  16. New method for true-triaxial rock testing

    SciTech Connect

    Wawersik, W.R.; Carlson, L.W.; Holcomb, D.J.; Williams, R.J.

    1997-03-01

    Two new and related true-triaxial apparatus are described that make use of conventional triaxial pressure vessels in combination with specially configured, high-pressure hydraulic jacks inside these vessels. The development combines advantages not found in existing facilities, including a compact design, pore-pressure and flow-through capabilities, the ability to attain high principal stresses and principal stress differences, direct access to parts of the sample, and provisions to go to relatively large deformations without developing serious stress field inhomogeneities.

  17. Comparing Science Achievement Constructs: Targeted and Achieved

    ERIC Educational Resources Information Center

    Ferrara, Steve; Duncan, Teresa

    2011-01-01

    This article illustrates how test specifications based solely on academic content standards, without attention to other cognitive skills and item response demands, can fall short of their targeted constructs. First, the authors inductively describe the science achievement construct represented by a statewide sixth-grade science proficiency test.…

  18. Which Achievement Gap?

    ERIC Educational Resources Information Center

    Anderson, Sharon; Medrich, Elliott; Fowler, Donna

    2007-01-01

    From the halls of Congress to the local elementary school, conversations on education reform have tossed around the term "achievement gap" as though people all know precisely what that means. As it's commonly used, "achievement gap" refers to the differences in scores on state or national achievement tests between various…

  19. Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive mef(A) or erm(B)] Streptococcus pneumoniae Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations

    PubMed Central

    Noreddin, Ayman M.; Roberts, Danielle; Nichol, Kim; Wierzbowski, Aleksandra; Hoban, Daryl J.; Zhanel, George G.

    2002-01-01

    The association between macrolide resistance mechanisms and clinical outcomes remains understudied. The present study, using an in vitro pharmacodynamic model, assessed clarithromycin (CLR) activity against mef(A)-positive and erm(B)-negative Streptococcus pneumoniae isolates by simulating free-drug concentrations in serum and both total (protein-bound and free) and free drug in epithelial lining fluid (ELF). Five mef(A)-positive and erm(B)-negative strains, one mef(A)-negative and erm(B)-positive strain, and a control [mef(A)-negative and erm(B)-negative] strain of S. pneumoniae were tested. CLR was modeled using a one-compartment model, simulating a dosage of 500 mg, per os, twice a day (in serum, free-drug Cp maximum of 2 μg/ml, t1/2 of 6 h; in ELF, CELF(total) maximum of 35μg/ml, t1/2 of 6 h; CELF(free) maximum of 14 μg/ml, t1/2 of 6 h). Starting inocula were 106 CFU/ml in Mueller-Hinton broth with 2% lysed horse blood. With sampling at 0, 4, 8, 12, 20, and 24 h, the extent of bacterial killing was assessed. Achieving CLR T/MIC values of ≥90% (AUC0-24/MIC ratio, ≥61) resulted in bacterial eradication, while T>MIC values of 40 to 56% (AUC0-24/MIC ratios of ≥30.5 to 38) resulted in a 1.2 to 2.0 log10 CFU/ml decrease at 24 h compared to that for the initial inoculum. CLR T/MIC values of ≤8% (AUC0-24/MIC ratio, ≤17.3) resulted in a static effect or bacterial regrowth. The high drug concentrations in ELF that were obtained clinically with CLR may explain the lack of clinical failures with mef(A)-producing S. pneumoniae strains, with MICs up to 8 μg/ml. However, mef(A) isolates for which MICs are ≥16 μg/ml along with erm(B) may result in bacteriological failures. PMID:12435719

  20. Pharmacodynamic modeling of clarithromycin against macrolide-resistant [PCR-positive mef(A) or erm(B)] Streptococcus pneumoniae simulating clinically achievable serum and epithelial lining fluid free-drug concentrations.

    PubMed

    Noreddin, Ayman M; Roberts, Danielle; Nichol, Kim; Wierzbowski, Aleksandra; Hoban, Daryl J; Zhanel, George G

    2002-12-01

    The association between macrolide resistance mechanisms and clinical outcomes remains understudied. The present study, using an in vitro pharmacodynamic model, assessed clarithromycin (CLR) activity against mef(A)-positive and erm(B)-negative Streptococcus pneumoniae isolates by simulating free-drug concentrations in serum and both total (protein-bound and free) and free drug in epithelial lining fluid (ELF). Five mef(A)-positive and erm(B)-negative strains, one mef(A)-negative and erm(B)-positive strain, and a control [mef(A)-negative and erm(B)-negative] strain of S. pneumoniae were tested. CLR was modeled using a one-compartment model, simulating a dosage of 500 mg, per os, twice a day (in serum, free-drug C(p) maximum of 2 micro g/ml, t(1/2) of 6 h; in ELF, C(ELF(total)) maximum of 35 micro g/ml, t(1/2) of 6 h; C(ELF(free)) maximum of 14 micro g/ml, t(1/2) of 6 h). Starting inocula were 10(6) CFU/ml in Mueller-Hinton broth with 2% lysed horse blood. With sampling at 0, 4, 8, 12, 20, and 24 h, the extent of bacterial killing was assessed. Achieving CLR T/MIC values of > or =90% (AUC(0-24)/MIC ratio, > or =61) resulted in bacterial eradication, while T>MIC values of 40 to 56% (AUC(0-24)/MIC ratios of > or =30.5 to 38) resulted in a 1.2 to 2.0 log(10) CFU/ml decrease at 24 h compared to that for the initial inoculum. CLR T/MIC values of < or =8% (AUC(0-24)/MIC ratio, < or =17.3) resulted in a static effect or bacterial regrowth. The high drug concentrations in ELF that were obtained clinically with CLR may explain the lack of clinical failures with mef(A)-producing S. pneumoniae strains, with MICs up to 8 micro g/ml. However, mef(A) isolates for which MICs are > or =16 micro g/ml along with erm(B) may result in bacteriological failures.

  1. Experimental and analytical studies of a true airspeed sensor

    NASA Technical Reports Server (NTRS)

    Goglia, G. L.; Shen, J. Y.

    1983-01-01

    A true airspeed sensor based on the precession of a vortex whistle for sensing airspeeds up to 321.9 km/hr (200 mph). In an attempt to model the complicated fluid mechanics of the vortex precession, three dimensional, inviscid, unsteady, incompressible fluid flow was studied by using the hydrodynamical linearized stability theory. The temporal stability approach was used to derive the relationship between the true airspeed and frequency response. The results show that the frequency response is linearly proportional to the airspeed. A computer program was developed to obtain the numerical solution. Computational results for various parameters were obtained. The designed sensor basically consisted of a vortex tube, a swirler, and a transducer system. A microphone converted the audible tone to an electronic frequency signal. Measurements for both the closed conduit tests and wind tunnel tests were recorded. For a specific flow rate or airspeed, larger exit swirler angles produced higher frequencies. For a smaller cross sectional area in the precessional flow region, the frequency was higher. It was observed that as the airspeed was increased the Strouhal number remained constant.

  2. Neural Correlates of True Memory, False Memory, and Deception

    PubMed Central

    Okuda, Jiro; Suzuki, Maki; Sasaki, Hiroshi; Matsuda, Tetsuya; Mori, Etsuro; Tsukada, Minoru; Fujii, Toshikatsu

    2008-01-01

    We used functional magnetic resonance imaging (fMRI) to determine whether neural activity can differentiate between true memory, false memory, and deception. Subjects heard a series of semantically related words and were later asked to make a recognition judgment of old words, semantically related nonstudied words (lures for false recognition), and unrelated new words. They were also asked to make a deceptive response to half of the old and unrelated new words. There were 3 main findings. First, consistent with the notion that executive function supports deception, 2 types of deception (pretending to know and pretending not to know) recruited prefrontal activity. Second, consistent with the sensory reactivation hypothesis, the difference between true recognition and false recognition was found in the left temporoparietal regions probably engaged in the encoding of auditorily presented words. Third, the left prefrontal cortex was activated during pretending to know relative to correct rejection and false recognition, whereas the right anterior hippocampus was activated during false recognition relative to correct rejection and pretending to know. These findings indicate that fMRI can detect the difference in brain activity between deception and false memory despite the fact that subjects respond with “I know” to novel events in both processes. PMID:18372290

  3. Neuroanatomical substrates involved in true and false memories for face.

    PubMed

    Iidaka, Tetsuya; Harada, Tokiko; Kawaguchi, Jun; Sadato, Norihiro

    2012-08-01

    We often mistake an unknown person for a familiar person because of the similarities in facial features. This phenomenon, known as false memory, has been investigated mainly using words, pictures, and shapes. Previous neuroimaging studies on false memory have shown that both true and false memories trigger a similar activation in the medial temporal lobe, suggesting that it plays a common role in both. However, no study to date has investigated neural substrates of false memories for faces. In the present fMRI study, we applied a modified version of the standard false memory paradigm, using morphed pictures of faces, to induce false memory in an MRI environment. We found that activity in the amygdala and orbital cortices was associated with the degree of familiarity of items. In particular, false responses to "lure" items evoked a level of activity in the amygdala between that evoked for correct or incorrect responses to "true" items. This indicates a possible role of the amygdala in false memory. A specific region in the anterior cingulate cortex was involved in false recognition; the activity being correlated to reaction times for the response types. These results suggest that the amygdala is involved in determining the relevance of items; therefore, ambiguousness of lure items in terms of familiarity and novelty may be related to decreased activity in the amygdala. The anterior cingulate activity in false memory may be caused not only by increased effort and motor demand but also by higher mnemonic processing of lure items.

  4. Computational challenges of emerging novel true 3D holographic displays

    NASA Astrophysics Data System (ADS)

    Cameron, Colin D.; Pain, Douglas A.; Stanley, Maurice; Slinger, Christopher W.

    2000-11-01

    A hologram can produce all the 3D depth cues that the human visual system uses to interpret and perceive real 3D objects. As such it is arguably the ultimate display technology. Computer generated holography, in which a computer calculates a hologram that is then displayed using a highly complex modulator, combines the ultimate qualities of a traditional hologram with the dynamic capabilities of a computer display producing a true 3D real image floating in space. This technology is set to emerge over the next decade, potentially revolutionizing application areas such as virtual prototyping (CAD-CAM, CAID etc.), tactical information displays, data visualization and simulation. In this paper we focus on the computational challenges of this technology. We consider different classes of computational algorithms from true computer-generated holograms (CGH) to holographic stereograms. Each has different characteristics in terms of image qualities, computational resources required, total CGH information content, and system performance. Possible trade- offs will be discussed including reducing the parallax. The software and hardware architectures used to implement the CGH algorithms have many possible forms. Different schemes, from high performance computing architectures to graphics based cluster architectures will be discussed and compared. Assessment will be made of current and future trends looking forward to a practical dynamic CGH based 3D display.

  5. Blood-feeding true bugs in the Early Cretaceous.

    PubMed

    Yao, Yunzhi; Cai, Wanzhi; Xu, Xing; Shih, Chungkun; Engel, Michael S; Zheng, Xiaoting; Zhao, Yunyun; Ren, Dong

    2014-08-04

    Blood-feeding insects, as vectors of disease for humans and livestock alike, have garnered significant interest, but our understanding of their early evolution is hindered by the scarcity of available material and the difficulty in distinguishing early hematophages from non-blood-feeding relatives. Here, we report a new family of true bugs including two new genera and species from the Early Cretaceous Yixian Formation in Northeastern China. By utilizing geochemical methods for determining their diets and combining morphological and taphonomic data, we demonstrate that these new species represent the earliest evidence of blood feeding among true bugs, extending the geological record of such lineages by approximately 30 million years. Remarkably, one of the bugs appears to have perished immediately following a blood meal, which may have been from coexisting mammals, birds, or avian-related dinosaurs. These records expand the phylogenetic and ecological diversity of blood-feeding insects in the Early Cretaceous, enriching our knowledge of paleoecological associations in these ancient environments.

  6. Teacher Licensing Examinations--True Progress or an Illusion?

    ERIC Educational Resources Information Center

    Libman, Zipora

    2009-01-01

    Over the past 10 years, public criticism of student achievement has been accompanied by a multitude of educational reforms, most of which emphasized the importance of setting national standards for student achievement and for the level and quality of teaching. The demand for frameworks to assess the extent to which students and teachers met the…

  7. High viscosity environments: an unexpected route to obtain true atomic resolution with atomic force microscopy.

    PubMed

    Weber, Stefan A L; Kilpatrick, Jason I; Brosnan, Timothy M; Jarvis, Suzanne P; Rodriguez, Brian J

    2014-05-02

    Atomic force microscopy (AFM) is widely used in liquid environments, where true atomic resolution at the solid-liquid interface can now be routinely achieved. It is generally expected that AFM operation in more viscous environments results in an increased noise contribution from the thermal motion of the cantilever, thereby reducing the signal-to-noise ratio (SNR). Thus, viscous fluids such as ionic and organic liquids have been generally avoided for high-resolution AFM studies despite their relevance to, e.g. energy applications. Here, we investigate the thermal noise limitations of dynamic AFM operation in both low and high viscosity environments theoretically, deriving expressions for the amplitude, phase and frequency noise resulting from the thermal motion of the cantilever, thereby defining the performance limits of amplitude modulation, phase modulation and frequency modulation AFM. We show that the assumption of a reduced SNR in viscous environments is not inherent to the technique and demonstrate that SNR values comparable to ultra-high vacuum systems can be obtained in high viscosity environments under certain conditions. Finally, we have obtained true atomic resolution images of highly ordered pyrolytic graphite and mica surfaces, thus revealing the potential of high-resolution imaging in high viscosity environments.

  8. True triaxial strength and deformability of crystalline rocks

    NASA Astrophysics Data System (ADS)

    Chang, Chandong

    A fundamental laboratory study was conducted in the deformation and strength of Westerly granite and KTB amphibolite subjected to true triaxial compressive stress conditions (sigma1 > sigma2 > sigma 3) with a particular attention to sigma2 effect on rock failure process. It was found that sigma2 strongly affects the criteria of strength for these rocks, contrary to the assumption contained in commonly accepted Mohr-type failure criteria. Under true triaxial stress conditions, crystalline rocks fail along a steeply inclined throughgoing shear fracture striking to the sigma2 direction. Stress-induced microcracks also develop mainly parallel to sigma2 direction, as the intermediate stress grows beyond sigma3, localizing along the plane that eventually becomes the throughgoing fracture. A general strength criterion can be expressed in terms of the octahedral shear stress and the mean normal stress acting on the failure plane. In a separate series of tests, failure of KTB amphibolite under borehole wall condition was simulated by leaving one pair of the prismatic specimens faces unjacketed and in direct contact with the confining fluid through which sigma 3 is applied. These tests reveal that brittle fracture occurs at a considerably lower stress level than that in dry amphibolite, and results from the development of a swarm of densely spaced extensile fractures subparallel and adjacent to one of the unjacketed faces. It is inferred that upon dilatancy onset, confining fluid intrudes microcracks, which are predominantly subparallel to the unjacketed faces, and promotes their elongation into throughgoing fractures. A true triaxial strength criterion of the unjacketed amphibolite can be expressed in terms of the octahedral shear stress as a function of the octahedral normal stress. The magnitudes of the maximum horizontal in situ stresses at the KTB hole, Germany, were computed based on the strength criterion of the unjacketed KTB amphibolite together with all the other

  9. A Monte Carlo approach to validation of FFF VMAT treatment plans for the TrueBeam linac

    SciTech Connect

    Gete, Ermias; Duzenli, Cheryl; Bergman, Alanah Mary; Milette, Marie-Pierre; Mestrovic, Ante; Hyde, Derek; Teke, Tony

    2013-02-15

    Purpose: To commission and benchmark a vendor-supplied (Varian Medical Systems) Monte Carlo phase-space data for the 6 MV flattening filter free (FFF) energy mode on a TrueBeam linear accelerator for the purpose of quality assurance of clinical volumetric modulated arc therapy (VMAT) treatment plans. A method for rendering the phase-space data compatible with BEAMnrc/DOSXYZnrc simulation software package is presented. Methods: Monte Carlo (MC) simulations were performed to benchmark the TrueBeam 6 MV FFF phase space data that have been released by the Varian MC Research team. The simulations to benchmark the phase space data were done in three steps. First, the original phase space which was created on a cylindrical surface was converted into a format that was compatible with BEAMnrc. Second, BEAMnrc was used to create field size specific phase spaces located underneath the jaws. Third, doses were calculated with DOSXYZnrc in a water phantom for fields ranging from 1 Multiplication-Sign 1 to 40 Multiplication-Sign 40 cm{sup 2}. Calculated percent depth doses (PDD), transverse profiles, and output factors were compared with measurements for all the fields simulated. After completing the benchmarking study, three stereotactic body radiotherapy (SBRT) VMAT plans created with the Eclipse treatment planning system (TPS) were calculated with Monte Carlo. Ion chamber and film measurements were also performed on these plans. 3D gamma analysis was used to compare Monte Carlo calculation with TPS calculations and with film measurement. Results: For the benchmarking study, MC calculated and measured values agreed within 1% and 1.5% for PDDs and in-field transverse profiles, respectively, for field sizes >1 Multiplication-Sign 1 cm{sup 2}. Agreements in the 80%-20% penumbra widths were better than 2 mm for all the fields that were compared. With the exception of the 1 Multiplication-Sign 1 cm{sup 2} field, the agreement between measured and calculated output factors was within

  10. Practice-Generated Questions: A Method of Formulating True Learning Needs of Family Physicians

    PubMed Central

    Jennett, Penny A.; Lockyer, Jocelyn M.; Parboosingh, I. John P.; Maes, William R.

    1989-01-01

    The importance of identifying true learning needs prior to planning and conducting educational programs is well documented. In this study a collection of 579 clinical questions forwarded by 87 family physicians in southern Alberta was reviewed and analysed to determine if the questions would cluster and, therefore, be useful as sources for planning continuing medical education (CME) conferences and newsletters. The nature of submitted questions was also examined to determine if particular groups of physicians, as identified by socio-demographic characteristics, significanly differed by type of questions submitted. The study findings indicate that the questions generated by the clinical practices of family practitioners did cluster into meaningful categories, and did vary significantly by identified physician groups. Questions relating to the genito-urinary system; adverse drug effects, interactions and contraindications; and nervous system and sense organs were most frequently submitted. The nature of questions generated differed significantly by gender, size of practice setting, and year and place of medical graduation. When highly relevant and specific clinical questions, as contrasted with broadly expressed needs, serve as sources of identified learning needs for CME planners, the daily clinical problems faced by practitioners are better addressed. The learning needs identified by this approach provide an optimum framework for planned CME to influence physician behaviour or practice patterns. PMID:21248985

  11. The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor.

    PubMed

    Servant, Guy; Tachdjian, Catherine; Li, Xiaodong; Karanewsky, Donald S

    2011-11-01

    A diet low in carbohydrates helps to reduce the amount of ingested calories and to maintain a healthy weight. With this in mind, food and beverage companies have reformulated a large number of their products, replacing sugar or high fructose corn syrup with several different types of zero-calorie sweeteners to decrease or even totally eliminate their caloric content. A challenge remains, however, with the level of acceptance of some of these products in the market-place. Many consumers believe that zero-calorie sweeteners simply do not taste like sugar. A recent breakthrough reveals that positive allosteric modulators of the human sweet taste receptor, small molecules that enhance the receptor activity and sweetness perception, could be more effective than other reported taste enhancers at reducing calories in consumer products without compromising on the true taste of sugar. A unique mechanism of action at the receptor level could explain the robust synergy achieved with these new modulators.

  12. Too good to be true: when overwhelming evidence fails to convince

    PubMed Central

    Chapeau-Blondeau, François; McDonnell, Mark D.; Davis, Bruce R.; Allison, Andrew; Abbott, Derek

    2016-01-01

    Is it possible for a large sequence of measurements or observations, which support a hypothesis, to counterintuitively decrease our confidence? Can unanimous support be too good to be true? The assumption of independence is often made in good faith; however, rarely is consideration given to whether a systemic failure has occurred. Taking this into account can cause certainty in a hypothesis to decrease as the evidence for it becomes apparently stronger. We perform a probabilistic Bayesian analysis of this effect with examples based on (i) archaeological evidence, (ii) weighing of legal evidence and (iii) cryptographic primality testing. In this paper, we investigate the effects of small error rates in a set of measurements or observations. We find that even with very low systemic failure rates, high confidence is surprisingly difficult to achieve; in particular, we find that certain analyses of cryptographically important numerical tests are highly optimistic, underestimating their false-negative rate by as much as a factor of 280. PMID:27118917

  13. True Color of Mars - Pathfinder Sol 39 Sunrise

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Sunrise, sol 39. This true color, pre-sunrise image (approximately 0530LST) is composed of six images extending 30 o in azimuth and 45 o in elevation and shows the brownish gray predawn sky. A description of the techniques used to generate this color image from IMP data can be found in Maki et al., 1999. Note: a calibrated output device is required accurately reproduce the correct colors.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal investigator.

  14. Liquid crystal thermography and true-colour digital image processing

    NASA Astrophysics Data System (ADS)

    Stasiek, J.; Stasiek, A.; Jewartowski, M.; Collins, M. W.

    2006-06-01

    In the last decade thermochromic liquid crystals (TLC) and true-colour digital image processing have been successfully used in non-intrusive technical, industrial and biomedical studies and applications. Thin coatings of TLCs at surfaces are utilized to obtain detailed temperature distributions and heat transfer rates for steady or transient processes. Liquid crystals also can be used to make visible the temperature and velocity fields in liquids by the simple expedient of directly mixing the liquid crystal material into the liquid (water, glycerol, glycol, and silicone oils) in very small quantities to use as thermal and hydrodynamic tracers. In biomedical situations e.g., skin diseases, breast cancer, blood circulation and other medical application, TLC and image processing are successfully used as an additional non-invasive diagnostic method especially useful for screening large groups of potential patients. The history of this technique is reviewed, principal methods and tools are described and some examples are also presented.

  15. True covariance simulation of the EUVE update filter

    NASA Technical Reports Server (NTRS)

    Bar-Itzhack, I. Y.; Harman, R. R.

    1990-01-01

    This paper presents a covariance analysis of the performance and sensitivity of the attitude determination Extended Kalman Filter (EKF) used by the On Board Computer (OBC) of the Extreme Ultra Violet Explorer (EUVE) spacecraft. The linearized dynamics and measurement equations of the error states are used in formulating the 'truth model' describing the real behavior of the systems involved. The 'design model' used by the OBC EKF is then obtained by reducing the order of the truth model. The covariance matrix of the EKF which uses the reduced order model is not the correct covariance of the EKF estimation error. A 'true covariance analysis' has to be carried out in order to evaluate the correct accuracy of the OBC generated estimates. The results of such analysis are presented which indicate both the performance and the sensitivity of the OBC EKF.

  16. True covariance simulation of the EUVE update filter

    NASA Technical Reports Server (NTRS)

    Bar-Itzhack, Itzhack Y.; Harman, R. R.

    1989-01-01

    A covariance analysis of the performance and sensitivity of the attitude determination Extended Kalman Filter (EKF) used by the On Board Computer (OBC) of the Extreme Ultra Violet Explorer (EUVE) spacecraft is presented. The linearized dynamics and measurement equations of the error states are derived which constitute the truth model describing the real behavior of the systems involved. The design model used by the OBC EKF is then obtained by reducing the order of the truth model. The covariance matrix of the EKF which uses the reduced order model is not the correct covariance of the EKF estimation error. A true covariance analysis has to be carried out in order to evaluate the correct accuracy of the OBC generated estimates. The results of such analysis are presented which indicate both the performance and the sensitivity of the OBC EKF.

  17. The True Deep Femoral Artery Aneurysm: A Case Report

    PubMed Central

    Jang, Lee Chan; Park, Sung Su

    2017-01-01

    A 55-year-old man with a palpable pulsatile mass and pain in his left thigh was presented to us. He had no history of trauma in his left leg, interventions, operation, or medical diseases, including cardiac valve disease, endocarditis, and systemic infection. The size of the aneurysm was 10 cm×7 cm with a mural thrombus in ultrasonography and multidetector computer tomography. There was no evidence of other aneurysms or occlusive lesions in the other arteries. The aneurysm was resected without a vascular reconstruction of the deep femoral artery. The patient’s symptom improved rapidly. The patient had an uneventful postoperative recovery without complications. We report a case of true deep femoral artery aneurysm, which was successfully treated with resection of an aneurysm without a vascular reconstruction. PMID:28377912

  18. Cercosporoid fungi (Mycosphaerellaceae) 3. Species on monocots (Poaceae, true grasses).

    PubMed

    Braun, Uwe; Crous, Pedro W; Nakashima, Chiharu

    2015-06-01

    The third part of a series of monographic treatments of cercosporoid fungi (formerly Cercospora s. lat., Mycosphaerellaceae, Ascomycota) continues with a treatment of taxa on monocots (Liliopsida; Equisetopsida, Magnoliidae, Lilianae), covering asexual and holomorph species with mycosphaerella-like sexual morphs on true grasses (Poaceae), which were excluded from the second part. The species concerned are keyed out, alphabetically listed, described, illustrated and supplemented by references to previously published descriptions, illustrations, and exsiccatae. A key to the recognised genera and a discussion of taxonomically relevant characters was published in the first part of this series. Several species are lecto- or neotypified. The following taxonomic novelties are introduced: Cercospora barretoana comb. nov., C. cymbopogonicola nom. nov., Cladosporium elymi comb. nov., Passalora agrostidicola sp. nov., P. brachyelytri comb. nov., and P. dichanthii-annulati comb. nov.

  19. Churned-Up Rocky Debris and Dust (True Color)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    NASA's Mars Exploration Rover Spirit has been analyzing sulfur-rich rocks and surface materials in the 'Columbia Hills' in Gusev Crater on Mars. This image shows rocky debris and dust, which planetary scientists call 'regolith' or 'soil,' that has been churned up by the rover wheels. This 40-centimeter-wide (16-inch-wide) patch of churned-up dirt, nicknamed 'Paso Robles,' contains brighter patches measured to be high in sulfur by Spirit's alpha particle X-ray Spectrometer. Spirit's panoramic camera took this image on martian day, or sol, 400 (Feb. 16, 2005). The image represents the panoramic camera team's best current attempt at generating a true color view of what this scene would look like if viewed by a human on Mars. The image was generated from a combination of six calibrated, left-eye images acquired through filters ranging from 430-nanometer to 750-nanometer wavelengths.

  20. Rising incidence of lymphoid malignancies--true or false?

    PubMed Central

    Barnes, N.; Cartwright, R. A.; O'Brien, C.; Richards, I. D.; Roberts, B.; Bird, C. C.

    1986-01-01

    The report contrasts the ascertainment of cases by the regional cancer registry with a specially designed search for records and pathology material which was then submitted to critical review irrespective of the original diagnosis. Boundary changes over the intervening years were accounted for and the results contrasted between time periods and with the cancer registry records. A large proportion of cancer registry cases were never subjected to histopathological diagnosis and comparisons between the new data and records are not easy to undertake. The study describes a probable true rise in the incidence of follicular non-Hodgkin's lymphoma in certain parts of Yorkshire over the last 20 years; there is less evidence of a similar change in Hodgkin's disease incidence over the same period of time. PMID:3964541

  1. Gravity constraints for True Polar Wander on Mars

    NASA Astrophysics Data System (ADS)

    Matsuyama, I.; Manga, M.

    2009-12-01

    The gravitational field of planetary bodies is commonly partitioned into hydrostatic and non-hydrostatic contributions (non-hydrostatic theory). However, this partitioning is not appropriate for planets like Mars with long-term elastic strength. Although Bills and James (1999) noted that the present Martian rotation pole would be unstable if the non-hydrostatic theory is adopted, previous studies used this theory to constrain true polar wander on Mars. We illustrate that the inferred paleopole position in these studies implies that the present rotation pole is unstable. Daradich et al. (2008) showed that the current rotation pole is stable, as expected, with a new theory that incorporates a partitioning into equilibrium and non-equilibrium contributions (non-equilibrium theory). They constrained the true polar wander on Mars driven by the formation of Tharsis using the non-equilibrium theory. We extend their analysis in several ways. First, Daradich et al. (2008) used the present location of Tharsis’ center location estimated in previous studies that adopt the non-hydrostatic theory. We estimate it using a semi-analytic procedure that is self-consistent with the non-equilibrium theory. This procedure can be used to remove Tharsis’ contribution from the observed gravity field. Second, Daradich et al. (2008) use the C20 and C22 gravity coefficients, and we extend their analysis to include the C21, S21, and S22 coefficients as additional constraints. Third, we take into account the effect of other surface loads with known locations (Elysium, Utopia, and Hellas). Finally, we quantify the size of the excess contributions required to explain the observed gravity field.

  2. [A study on the true nature of "Chinese jinseng"].

    PubMed

    Yang, Jeong-pil; Yeo, In-sok

    2003-12-01

    Studies generally, it is believed that the ancient 'Chinese ginseng' did exist due to the fact that it is clearly recorded in the Chinese historical and medicine-related sources. Although it is hard to deny that such 'ginseng' did exist in ancient China, the re-examination of its true nature is also necessary. In other words, certain refutation can be made against the claim that ancient 'Chinese jinseng' was in fact 'Panax jinseng' (C. A. Mey.), since the Chinese jinseng accounts do not tell that it is such. For example, when looking into its shape based on descriptions, the 'Chinese Jinseng' has black seed, hairy stem, and violet flower. ' Panax jinseng' on the other hand, has opal seed, no-hair stem, and light-green flower. In terms of cultivation centre, most of mainland China is unsuitable for Jinseng production with the exception of the Shangdang area of Shanxi province, which solely had the reputation of being the production centre of ancient 'Chinese jinseng'. However, when looking into the Chinese sources for jinseng-producing areas, they show that Hepei and Liaoning province and Jiangnan (south of the Yangtze river) areas also have had some jinseng-related history. Regardless of such instance, these regions did not cultivate Panax jinseng. As shown above, ancient 'Chinese jinseng' was far from being identical, in respect to its shape or production areas, to Panax jinseng. Hence, this study came to the conclusion that there is indeed very high skepticism about whether the true nature of 'jinseng' in ancient China was in fact Panax jinseng. On the contrary, there is higher possibility that the ancient 'Chinese jinseng' is totally different plant from Panax jinseng which is actually Codonopsis pilosula. When examining the shape and production areas of Codonopsis pilosula, it is closely matched with many parts of ancient 'Chinese jinseng' texts. In short, it is presumed that the 'Chinese jinseng' did indeed exist in ancient China but it was Codonopsis pilosula

  3. Tunable Optical True-Time Delay Devices Would Exploit EIT

    NASA Technical Reports Server (NTRS)

    Kulikov, Igor; DiDomenico, Leo; Lee, Hwang

    2004-01-01

    Tunable optical true-time delay devices that would exploit electromagnetically induced transparency (EIT) have been proposed. Relative to prior true-time delay devices (for example, devices based on ferroelectric and ferromagnetic materials) and electronically controlled phase shifters, the proposed devices would offer much greater bandwidths. In a typical envisioned application, an optical pulse would be modulated with an ultra-wideband radio-frequency (RF) signal that would convey the information that one seeks to communicate, and it would be required to couple differently delayed replicas of the RF signal to the radiating elements of a phased-array antenna. One or more of the proposed devices would be used to impose the delays and/or generate the delayed replicas of the RF-modulated optical pulse. The beam radiated or received by the antenna would be steered by use of a microprocessor-based control system that would adjust operational parameters of the devices to tune the delays to the required values. EIT is a nonlinear quantum optical interference effect that enables the propagation of light through an initially opaque medium. A suitable medium must have, among other properties, three quantum states (see Figure 1): an excited state (state 3), an upper ground state (state 2), and a lower ground state (state 1). These three states must form a closed system that exhibits no decays to other states in the presence of either or both of two laser beams: (1) a probe beam having the wavelength corresponding to the photon energy equal to the energy difference between states 3 and 1; and (2) a coupling beam having the wavelength corresponding to the photon energy equal to the energy difference between states 3 and 2. The probe beam is the one that is pulsed and modulated with an RF signal.

  4. A true polar wander model for Neoproterozoic plate motions

    SciTech Connect

    Ripperdan, R.L. )

    1992-01-01

    Recent paleogeographic reconstructions for the interval 750--500 Ma (Neoproterozoic to Late Cambrian) require rapid rates of plate motion and/or rotation around an equatorial Euler pole to accommodate reconstructions for the Early Paleozoic. Motions of this magnitude appear to be very uncommon during the Phanerozoic. A model for plate motions based on the hypothesis that discrete intervals of rapid true polar wander (RTPW) occurred during the Neoproterozoic can account for the paleogeographic changes with minimum amounts of plate motion. The model uses the paleogeographic reconstructions of Hoffman (1991). The following constraints were applied during derivation of the model: (1) relative motions between major continental units were restricted to be combinations of great circle or small circle translations with Euler poles of rotation = spin axis; (2) maximum rates of relative translational plate motion were 0.2 m/yr. Based on these constraints, two separate sets of synthetic plate motion trajectories were determined. The sequence of events in both can be summarized as: (1) A rapid true polar wander event of ca 90[degree] rafting a supercontinent to the spin axis; (2) breakup of the polar supercontinent into two fragments, one with the Congo, West Africa, Amazonia, and Baltica cratons, the other with the Laurentia, East Gondwana, and Kalahari cratons; (3) great circle motion of the blocks towards the equator; (4) small circle motion leading to amalgamation of Gondwana and separation of Laurentia and Baltica. In alternative 1, rifting initiates between East Antarctica and Laurentia and one episode of RTPW is required. Alternative 2 requires two episodes of RTPW; and that rifting occurred first along the eastern margin and later along the western margin of Laurentia. Synthetic plate motion trajectories are compared to existing paleomagnetic and geological data, and implications of the model for paleoclimatic changes during the Neoproterozoic are discussed.

  5. It's time to make management a true profession.

    PubMed

    Khurana, Rakesh; Nohria, Nitin

    2008-10-01

    In the face of the recent institutional breakdown of trust in business, managers are losing legitimacy. To regain public trust, management needs to become a true profession in much the way medicine and law have, argue Khurana and Nohria of Harvard Business School. True professions have codes, and the meaning and consequences of those codes are taught as part of the formal education required of their members. Through these codes, professional institutions forge an implicit social contract with society: Trust us to control and exercise jurisdiction over an important occupational category, and, in return, we will ensurethat the members of our profession are worthy of your trust--that they will not only be competent to perform the tasks entrusted to them, but that they will also conduct themselves with high standardsand great integrity. The authors believe that enforcing educational standards and a code of ethics is unlikely to choke entrepreneurial creativity. Indeed, if the field of medicine is any indication, a code may even stimulate creativity. The main challenge in writing a code lies in reaching a broad consensus on the aims and social purpose of management. There are two deeply divided schools of thought. One school argues that management's aim should simply be to maximize shareholder wealth; the other argues that management's purpose is to balance the claims of all the firm's stakeholders. Any code will have to steer a middle course in order to accommodate both the value-creating impetus of the shareholder value concept and the accountability inherent in the stakeholder approach.

  6. Murder and robbery by vehicular impact: true vehicular homicide.

    PubMed

    Nadesan, K

    2000-06-01

    True vehicular homicides are defined as those occurrences in which a motor vehicle is intentionally used as a weapon in taking of a life. A case is presented in which the deceased was traveling in the front passenger seat of a motor car that was deliberately rammed by a heavy jeep that came in the opposite direction, resulting in a serious frontal collision. Immediately after the impact, while the occupants of the car were lying in a dazed condition, the two persons riding in the jeep escaped with a bag containing money that was in the car, leaving the jeep behind. The impact mainly involved the driver's sides of both vehicles. The driver of the car sustained serious injuries but was found to be alive, whereas the front-seat passenger, who did not show any serious external injuries, was found to be in a collapsed state and was pronounced dead on admission to the hospital within 30 minutes of the accident. The autopsy revealed that death was caused by closed hemopericardium from a ruptured right atrium. The evaluation of the external and internal injuries confirmed that the fatal injury and a few serious internal injuries were caused by the seat belt (tertiary-impact injuries). The ruptured right atrium was attributed to blunt abdominal trauma by impacting against the lap belt. The case was a true vehicular homicide in which a motor vehicle had been used as a weapon to kill a person. Various aspects pertaining to road accidents, the safety of the occupants, and the advantage and disadvantage of the safety devices are discussed.

  7. Lunar true polar wander inferred from polar hydrogen.

    PubMed

    Siegler, M A; Miller, R S; Keane, J T; Laneuville, M; Paige, D A; Matsuyama, I; Lawrence, D J; Crotts, A; Poston, M J

    2016-03-24

    The earliest dynamic and thermal history of the Moon is not well understood. The hydrogen content of deposits near the lunar poles may yield insight into this history, because these deposits (which are probably composed of water ice) survive only if they remain in permanent shadow. If the orientation of the Moon has changed, then the locations of the shadowed regions will also have changed. The polar hydrogen deposits have been mapped by orbiting neutron spectrometers, and their observed spatial distribution does not match the expected distribution of water ice inferred from present-day lunar temperatures. This finding is in contrast to the distribution of volatiles observed in similar thermal environments at Mercury's poles. Here we show that polar hydrogen preserves evidence that the spin axis of the Moon has shifted: the hydrogen deposits are antipodal and displaced equally from each pole along opposite longitudes. From the direction and magnitude of the inferred reorientation, and from analysis of the moments of inertia of the Moon, we hypothesize that this change in the spin axis, known as true polar wander, was caused by a low-density thermal anomaly beneath the Procellarum region. Radiogenic heating within this region resulted in the bulk of lunar mare volcanism and altered the density structure of the Moon, changing its moments of inertia. This resulted in true polar wander consistent with the observed remnant polar hydrogen. This thermal anomaly still exists and, in part, controls the current orientation of the Moon. The Procellarum region was most geologically active early in lunar history, which implies that polar wander initiated billions of years ago and that a large portion of the measured polar hydrogen is ancient, recording early delivery of water to the inner Solar System. Our hypothesis provides an explanation for the antipodal distribution of lunar polar hydrogen, and connects polar volatiles to the geologic and geophysical evolution of the Moon

  8. Comparison of True and Smoothed Puff Profile Replication on Smoking Behavior and Mainstream Smoke Emissions

    PubMed Central

    2015-01-01

    To estimate exposures to smokers from cigarettes, smoking topography is typically measured and programmed into a smoking machine to mimic human smoking, and the resulting smoke emissions are tested for relative levels of harmful constituents. However, using only the summary puff data—with a fixed puff frequency, volume, and duration—may underestimate or overestimate actual exposure to smoke toxins. In this laboratory study, we used a topography-driven smoking machine that faithfully reproduces a human smoking session and individual human topography data (n = 24) collected during previous clinical research to investigate if replicating the true puff profile (TP) versus the mathematically derived smoothed puff profile (SM) resulted in differences in particle size distributions and selected toxic/carcinogenic organic compounds from mainstream smoke emissions. Particle size distributions were measured using an electrical low pressure impactor, the masses of the size-fractionated fine and ultrafine particles were determined gravimetrically, and the collected particulate was analyzed for selected particle-bound, semivolatile compounds. Volatile compounds were measured in real time using a proton transfer reaction-mass spectrometer. By and large, TP levels for the fine and ultrafine particulate masses as well as particle-bound organic compounds were slightly lower than the SM concentrations. The volatile compounds, by contrast, showed no clear trend. Differences in emissions due to the use of the TP and SM profiles are generally not large enough to warrant abandoning the procedures used to generate the simpler smoothed profile in favor of the true profile. PMID:25536227

  9. Incidental finding of a true human tail in an adult: a case report.

    PubMed

    Robinson, Caitlin G; Duke, Taylor C; Allison, Ashley W

    2017-01-01

    True human tails are rare vestigial structures that are typically removed in childhood. Here a case is presented in which an inconspicuous sacrococcygeal tail was incidentally discovered in late adulthood. A 56-year-old man with no significant past medical history presented to a dermatology clinic with a chief complaint of a hyperpigmented lesion on his central back. However, on full body skin exam, a separate flesh-colored 0.7 cm × 0.5 cm appendage was discovered in the midline sacrococcygeal region. This lesion had been present and unchanged since childhood. This particular lesion was removed via shave biopsy. Microscopic exam found it to be consistent with a diagnosis of a true human tail. There were no apparent involved spinal cord structures, and no further treatment was thought to be necessary. Human tails are congenital anomalies associated with occult spinal lesions in about 50% of cases. Therefore, it is in these patients' best interest to thoroughly evaluate for spinal cord involvement prior to biopsy. There is a relative lack of literature published on the topic, and a greater awareness of human tails would be helpful to ensure their inclusion in a differential diagnosis for persistent sacrococcygeal lesions in patients of any age.

  10. Achieving Cannabis Cessation - Evaluating N-acetylcysteine Treatment (ACCENT): Design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network

    PubMed Central

    McClure, Erin A.; Sonne, Susan C.; Winhusen, Theresa; Carroll, Kathleen M.; Ghitza, Udi E.; McRae-Clark, Aimee L.; Matthews, Abigail G.; Sharma, Gaurav; Van Veldhuisen, Paul; Vandrey, Ryan G.; Levin, Frances R.; Weiss, Roger D.; Lindblad, Robert; Allen, Colleen; Mooney, Larissa J.; Haynes, Louise; Brigham, Gregory S.; Sparenborg, Steve; Hasson, Albert L.; Gray, Kevin M.

    2014-01-01

    Despite recent advances in behavioral interventions for cannabis use disorders, effect sizes remain modest, and few individuals achieve long-term abstinence. One strategy to enhance outcomes is the addition of pharmacotherapy to complement behavioral treatment, but to date no efficacious medications targeting cannabis use disorders in adults through large, randomized controlled trials have been identified. The National Institute on Drug Abuse Clinical Trials Network (NIDA CTN) is currently conducting a study to test the efficacy of N-acetylcysteine (NAC) versus placebo (PBO), added to contingency management, for cannabis cessation in adults (ages 18–50). This study was designed to replicate positive findings from a study in cannabis-dependent adolescents that found greater odds of abstinence with NAC compared to PBO. This paper describes the design and implementation of an ongoing 12-week, intent-to-treat, double-blind, randomized, placebo-controlled study with one follow-up visit four weeks post-treatment. Approximately 300 treatment-seeking cannabis-dependent adults will be randomized to NAC or PBO across six study sites in the United States. The primary objective of this 12-week study is to evaluate the efficacy of twice-daily orally-administered NAC (1200 mg) versus matched PBO, added to contingency management, on cannabis abstinence. NAC is among the first medications to demonstrate increased odds of abstinence in a randomized controlled study among cannabis users in any age group. The current study will assess the cannabis cessation efficacy of NAC combined with a behavioral intervention in adults, providing a novel and timely contribution to the evidence base for the treatment of cannabis use disorders. PMID:25179587

  11. 44 CFR 321.4 - Achieving production readiness.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Achieving production readiness. 321.4 Section 321.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS MAINTENANCE OF THE MOBILIZATION BASE (DEPARTMENT OF...

  12. Effects of calcium feeding strategy on true ileal phosphorus digestibility and true phosphorus retention determined with growing broilers.

    PubMed

    Perryman, K R; Masey O'Neill, H V; Bedford, M R; Dozier, W A

    2016-05-01

    An experiment utilizing 960 Ross × Ross 708 male broilers was conducted to determine the effects of Ca feeding strategy on true ileal (prececal) P digestibility (TIPD) and true P retention (TPR) of corn. Experimental diets were formulated with 1 of 3 dietary Ca feeding strategies (0.95%, 0.13%, or variable Ca concentrations to maintain a 2.1:1 Ca:P ratio) and contain 0, 25, 50, or 75% corn. A practical corn-soybean meal diet (1.4:1 Ca:P ratio) was fed as a control. After receiving a common starter diet, experimental diets were fed from 19 to 26 d of age. After a 48-h dietary adaptation period, a 48-h retention assay was conducted. At 25 and 26 d of age, ileal digesta were collected from 8 birds per cage. Broilers consuming the control diet had higher (P<0.001) BW gain, feed intake, digesta P, and excreta P than broilers consuming the corn titration diets. Digesta and excreta P increased (linear, P<0.05) with graded increases of corn. True ileal P digestibility and TPR were highest (P<0.05) for diets with 0.13% Ca (57.3 and 69.5%, respectively) compared with diets formulated with a 2.1:1 Ca:P ratio (41.2 and 37.8%, respectively) or 0.95% Ca (25.4 and 39.0%, respectively). Values for TPR were higher (P<0.05) than those for TIPD except when the dietary Ca:P ratio was fixed. Additionally, negative endogenous P losses were predicted by regression equations when TPR was estimated for birds fed titration diets with the fixed Ca:P ratio. Changing the Ca concentration of the diets to maintain a fixed Ca:P ratio influenced (P<0.001) apparent P retention, which affected the estimate for TPR due to the prediction of negative endogenous P losses. These data demonstrated that regression analysis may have limitations when estimating the TIPD or TPR of corn when formulating diets with different Ca feeding strategies. More research is necessary to elucidate the factors that contributed to regression equations predicting negative endogenous P losses.

  13. 'No delays achiever'.

    PubMed

    2007-05-01

    The latest version of the NHS Institute for Innovation and Improvement's 'no delays achiever', a web based tool created to help NHS organisations achieve the 18-week target for GP referrals to first treatment, is available at www.nodelaysachiever.nhs.uk.

  14. Vicarious Achievement Orientation.

    ERIC Educational Resources Information Center

    Leavitt, Harold J.; And Others

    This study tests hypotheses about achievement orientation, particularly vicarious achievement. Undergraduate students (N=437) completed multiple-choice questionnaires, indicating likely responses of one person to the success of another. The sex of succeeder and observer, closeness of relationship, and setting (medical school or graduate school of…

  15. Heritability of Creative Achievement

    ERIC Educational Resources Information Center

    Piffer, Davide; Hur, Yoon-Mi

    2014-01-01

    Although creative achievement is a subject of much attention to lay people, the origin of individual differences in creative accomplishments remain poorly understood. This study examined genetic and environmental influences on creative achievement in an adult sample of 338 twins (mean age = 26.3 years; SD = 6.6 years). Twins completed the Creative…

  16. Confronting the Achievement Gap

    ERIC Educational Resources Information Center

    Gardner, David

    2007-01-01

    This article talks about the large achievement gap between children of color and their white peers. The reasons for the achievement gap are varied. First, many urban minorities come from a background of poverty. One of the detrimental effects of growing up in poverty is receiving inadequate nourishment at a time when bodies and brains are rapidly…

  17. Achievement-Based Resourcing.

    ERIC Educational Resources Information Center

    Fletcher, Mike; And Others

    1992-01-01

    This collection of seven articles examines achievement-based resourcing (ABR), the concept that the funding of educational institutions should be linked to their success in promoting student achievement, with a focus on the application of ABR to postsecondary education in the United Kingdom. The articles include: (1) "Introduction" (Mick…

  18. States Address Achievement Gaps.

    ERIC Educational Resources Information Center

    Christie, Kathy

    2002-01-01

    Summarizes 2 state initiatives to address the achievement gap: North Carolina's report by the Advisory Commission on Raising Achievement and Closing Gaps, containing an 11-point strategy, and Kentucky's legislation putting in place 10 specific processes. The North Carolina report is available at www.dpi.state.nc.us.closingthegap; Kentucky's…

  19. Achievement Motivation and the Adolescent Musician: A Synthesis of the Literature

    ERIC Educational Resources Information Center

    Schatt, Matthew D.

    2011-01-01

    Motivation plays a role in nearly all human decision-making processes. Regardless of the situation, little may be achieved without the appropriate harnessing of motivation. The same is true in the music classroom. Research appears to indicate that motivation plays a crucial role in human development and achievement. The achievement motivation…

  20. A Novel True Triaxial Apparatus to Study the Geomechanical and Fluid Flow Aspects of Energy Exploitations in Geological Formations

    NASA Astrophysics Data System (ADS)

    Li, Minghui; Yin, Guangzhi; Xu, Jiang; Li, Wenpu; Song, Zhenlong; Jiang, Changbao

    2016-12-01

    Fluid-solid coupling investigations of the geological storage of CO2, efficient unconventional oil and natural gas exploitations are mostly conducted under conventional triaxial stress conditions ( σ 2 = σ 3), ignoring the effects of σ 2 on the geomechanical properties and permeability of rocks (shale, coal and sandstone). A novel multi-functional true triaxial geophysical (TTG) apparatus was designed, fabricated, calibrated and tested to simulate true triaxial stress ( σ 1 > σ 2 > σ 3) conditions and to reveal geomechanical properties and permeability evolutions of rocks. The apparatus was developed with the capacity to carry out geomechanical and fluid flow experiments at high three-dimensional loading forces and injection pressures under true triaxial stress conditions. The control and measurement of the fluid flow with effective sealing of rock specimen corners were achieved using a specially designed internally sealed fluid flow system. To validate that the apparatus works properly and to recognize the effects of each principal stress on rock deformation and permeability, stress-strain and permeability experiments and a hydraulic fracturing simulation experiment on shale specimens were conducted under true triaxial stress conditions using the TTG apparatus. Results show that the apparatus has advantages in recognizing the effects of σ 2 on the geomechanical properties and permeability of rocks. Results also demonstrate the effectiveness and reliability of the novel TTG apparatus. The apparatus provides a new method of studying the geomechanical properties and permeability evolutions of rocks under true triaxial stress conditions, promoting further investigations of the geological storage of CO2, efficient unconventional oil and gas exploitations.

  1. Use of TrueBeam developer mode for imaging QA.

    PubMed

    Valdes, Gilmer; Morin, Olivier; Valenciaga, Yanisley; Kirby, Niel; Pouliot, Jean; Chuang, Cynthia

    2015-07-08

    The purpose of this study was to automate regular Imaging QA procedures to become more efficient and accurate. Daily and monthly imaging QA for SRS and SBRT protocols were fully automated on a Varian linac. A three-step paradigm where the data are automatically acquired, processed, and analyzed was defined. XML scripts were written and used in developer mode in a TrueBeam linac to automatically acquire data. MATLAB R013B was used to develop an interface that could allow the data to be processed and analyzed. Hardware was developed that allowed the localization of several phantoms simultaneously on the couch. 14 KV CBCTs from the Emma phantom were obtained using a TrueBeam onboard imager as example of data acquisition and analysis. The images were acquired during two months. Artifacts were artificially introduced in the images during the reconstruction process using iTool reconstructor. Support vector machine algorithms to automatically identify each artifact were written using the Machine Learning MATLAB R2011 Toolbox. A daily imaging QA test could be performed by an experienced medical physicist in 14.3 ± 2.4 min. The same test, if automated using our paradigm, could be performed in 4.2 ± 0.7 min. In the same manner, a monthly imaging QA could be performed by a physicist in 70.7 ± 8.0 min and, if fully automated, in 21.8 ± 0.6 min. Additionally, quantitative data analysis could be automatically performed by Machine Learning Algorithms that could remove the subjectivity of data interpretation in the QA process. For instance, support vector machine algorithms could correctly identify beam hardening, rings and scatter artifacts. Traditional metrics, as well as metrics that describe texture, are needed for the classification. Modern linear accelerators are equipped with advanced 2D and 3D imaging capabilities that are used for patient alignment, substantially improving IGRT treatment accuracy. However, this extra complexity exponentially increases the number of QA

  2. Production of the Smallest QED Atom: True Muonium ({mu}{sup +}{mu}{sup -})

    SciTech Connect

    Brodsky, Stanley J.; Lebed, Richard F.

    2009-05-29

    The 'true muonium' ({mu}{sup +}{mu}{sup -}) and 'true tauonium' ({tau}{sup +}{tau}{sup -}) bound states are not only the heaviest, but also the most compact pure QED systems. The rapid weak decay of the {tau} makes the observation of true tauonium difficult. However, as we show, the production and study of true muonium is possible at modern electron-positron colliders.

  3. Achievability for telerobotic systems

    NASA Astrophysics Data System (ADS)

    Kress, Reid L.; Draper, John V.; Hamel, William R.

    2001-02-01

    Methods are needed to improve the capabilities of autonomous robots to perform tasks that are difficult for contemporary robots, and to identify those tasks that robots cannot perform. Additionally, in the realm of remote handling, methods are needed to assess which tasks and/or subtasks are candidates for automation. We are developing a new approach to understanding the capability of autonomous robotic systems. This approach uses formalized methods for determining the achievability of tasks for robots, that is, the likelihood that an autonomous robot or telerobot can successfully complete a particular task. Any autonomous system may be represented in achievability space by the volume describing that system's capabilities within the 3-axis space delineated by perception, cognition, and action. This volume may be thought of as a probability density with achievability decreasing as the distance from the centroid of the volume increases. Similarly, any task may be represented within achievability space. However, as tasks have more finite requirements for perception, cognition, and action, each may be represented as a point (or, more accurately, as a small sphere) within achievability space. Analysis of achievability can serve to identify, a priori, the survivability of robotic systems and the likelihood of mission success; it can be used to plan a mission or portions of a mission; it can be used to modify a mission plan to accommodate unpredicted occurrences; it can also serve to identify needs for modifications to robotic systems or tasks to improve achievability. .

  4. In search of the true self: a clinical journey through the vale of soul-making.

    PubMed

    Wilkin, P

    2006-02-01

    Once a person accepts any form of mainstream mental health care, she is faced with the paradox of disabling caring. Every time an emotionally distressed individual is professionally rescued, she forfeits a golden opportunity to discover and utilize her own healing potential. Yet within a mental health service that is heavily medicalized and investing more and more in time-limited therapies, can it ever be otherwise? Drawing on the developmental theory of Donald Winnicott, together with the poet John Keats' concept of 'Soul-making', this case study provides an account of therapy delivered from outside the parameters of a health-illness model of caring. It acknowledges human suffering as a natural and inevitable part of life and, whilst acknowledging the value of therapeutic companionship, proclaims the mentally distressed person as best placed to navigate her own recovery.

  5. Linguistic Determinants of the Difficulty of True-False Test Items

    ERIC Educational Resources Information Center

    Peterson, Candida C.; Peterson, James L.

    1976-01-01

    Adults read a prose passage and responded to passages based on it which were either true or false and were phrased either affirmatively or negatively. True negatives yielded most errors, followed in order by false negatives, true affirmatives, and false affirmatives. (Author/RC)

  6. Linear Prediction of a True Score from a Direct Estimate and Several Derived Estimates

    ERIC Educational Resources Information Center

    Haberman, Shelby J.; Qian, Jiahe

    2007-01-01

    Statistical prediction problems often involve both a direct estimate of a true score and covariates of this true score. Given the criterion of mean squared error, this study determines the best linear predictor of the true score given the direct estimate and the covariates. Results yield an extension of Kelley's formula for estimation of the true…

  7. On the true velocity in full correlation analysis

    NASA Astrophysics Data System (ADS)

    Woodman, Ronald F.

    1995-09-01

    The usual assumption made of elliptical symmetry in the shape of the correlation functions for deriving algorithms to determine the "true" velocity of a time-changing random pattern is relaxed. We start, instead, by stating that in the frame of reference moving with the medium, the space-time autocorrelation function of any state parameter of the medium is invariant under an r = -r transformation, where r is the displacement vector. With no further assumptions, a simple formula for the velocity of the medium is found for statistically isotropic patterns and for anisotropic patterns when the sensors are aligned along the axis of symmetry. The simplicity of the derivation and the formula contrast with previous derivations under more restrictive conditions. For the case of unknown elongation direction, previously known algorithms for determining the velocity under the assumption that the locus of equal correlation in r space are elliptical are revised. They are derived as Taylor expansion approximations of the functions specifying the shape of equal correlation shells. Furthermore, the assumption of fixed elliptical elongation parameters is relaxed. Three-dimensional cases are considered throughout, with one- and two-dimensional applications included as special cases.

  8. The quest for a true One Health perspective of brucellosis.

    PubMed

    Godfroid, J; DeBolle, X; Roop, R M; O'Callaghan, D; Tsolis, R M; Baldwin, C; Santos, R L; McGiven, J; Olsen, S; Nymo, I H; Larsen, A; Al Dahouk, S; Letesson, J J

    2014-08-01

    One Health is an interdisciplinary collaboration that aims at mitigating risks to human health arising from microorganisms present in non-human animal species, which have the potential to be transmitted and cause disease in humans. Different degrees of scientific collaboration and sectoral integration are needed for different types of zoonotic diseases, depending on the health and associated economic gains that can be expected from a One Health approach. Indeed, mitigating zoonotic risks related to emerging diseases with pandemic potential is different from mitigating risks related to endemic zoonotic diseases like brucellosis. Likewise, management of brucellosis at the wildlife-livestock interface in wildlife conservation areas is in essence different from mitigating transmission of a given Brucella species within its preferential host species, which in turn is different from mitigating the spillover of a given Brucella species to non-preferential host species, humans included. Brucellosis economic models often oversimplify and/or wrongly assess transmission between reservoir hosts and spillover hosts. Moreover,they may not properly value non-market outcomes, such as avoidance of human disease, consumer confidence and conservation biology issues. As a result, uncertainty is such that the economic predictions of these models can be questionable. Therefore, understanding the infection biology of Brucella species is a prerequisite. This paper reviews and highlights important features of the infection biology of Brucella species and the changing epidemiology of brucellosis that need to be integrated into a true One Health perspective of brucellosis.

  9. True Color of Mars - Pathfinder Sol 24 at 4 PM

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The brownish gray sky as it would be seen by an observer on Mars in this four-frame, true color mosaic taken on sol 24 (at approximately 1610 LST). The twin peaks can be seen on the horizon. The sky near the sun is a pale blue color. Azimuth extent is 60o and elevation extent is approximately 12odegrees. A description of the techniques used to generate this color image from IMP data can be found in Maki et al., 1999 (see full reference in Image Note). Note: a calibrated output device is required accurately reproduce the correct colors.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal investigator.

  10. True 3D displays for avionics and mission crewstations

    NASA Astrophysics Data System (ADS)

    Sholler, Elizabeth A.; Meyer, Frederick M.; Lucente, Mark E.; Hopper, Darrel G.

    1997-07-01

    3D threat projection has been shown to decrease the human recognition time for events, especially for a jet fighter pilot or C4I sensor operator when the advantage of realization that a hostile threat condition exists is the basis of survival. Decreased threat recognition time improves the survival rate and results from more effective presentation techniques, including the visual cue of true 3D (T3D) display. The concept of 'font' describes the approach adopted here, but whereas a 2D font comprises pixel bitmaps, a T3D font herein comprises a set of hologram bitmaps. The T3D font bitmaps are pre-computed, stored, and retrieved as needed to build images comprising symbols and/or characters. Human performance improvement, hologram generation for a T3D symbol font, projection requirements, and potential hardware implementation schemes are described. The goal is to employ computer-generated holography to create T3D depictions of a dynamic threat environments using fieldable hardware.

  11. [Maternity in adolescence: a dream come true and future expectation].

    PubMed

    de Andrade, Paula Rosenberg; Ribeiro, Circéa Amalia; Ohara, Conceição Vieira da Silva

    2009-12-01

    This qualitative study aimed at describing the reasons that motivate an adolescent to get pregnant and her expectations about the future after the child's birth. Symbolic Interactionism was used as theoretical framework and Grounded Theory as the methodological one. Eight adolescent mothers aged between 15 and 19 years who lived the experience of caring for their children took part in the study. Data collection tools were observant participation and semi-structured interviews. Data analysis revealed that becoming a mother is an experience that might be desired and even planned. Furthermore, data showed that after the child's birth, the adolescent continues to have expectations of self-realization in order to provide a better future for herself and for her child, as revealed by the categories: Making a dream come true and Having expectations about the future. The full understanding of this experience will contribute to the practice of all professionals that provide assistance to pregnant and adolescent mothers at different levels of healthcare.

  12. [Isolated true aneurysm of the deep femoral artery].

    PubMed

    Salomon du Mont, L; Holzer, T; Kazandjian, C; Saucy, F; Corpataux, J M; Rinckenbach, S; Déglise, S

    2016-07-01

    Aneurysms of the deep femoral artery, accounting for 5% of all femoral aneurysms, are uncommon. There is a serious risk of rupture. We report the case of an 83-year-old patient with a painless pulsatile mass in the right groin due to an aneurysm of the deep femoral artery. History taking revealed no cardiovascular risk factors and no other aneurysms at other localizations. The etiology remained unclear because no recent history of local trauma or puncture was found. ACT angiography was performed, revealing a true isolated aneurysm of the deep femoral artery with a diameter of 90mm, beginning 1cm after its origin. There were no signs of rupture or distal emboli. Due to unsuitable anatomy for an endovascular approach, the patient underwent open surgery, with exclusion of the aneurysm and interposition of an 8-mm Dacron graft to preserve deep femoral artery flow. Due to their localization, the diagnosis and the management of aneurysms of the deep femoral artery can be difficult. Options are surgical exclusion or an endovascular approach in the absence of symptoms or as a bridging therapy. If possible, blood flow to the distal deep femoral artery should be maintained, the decision depending also on the patency of the superficial femoral artery. In case of large size, aneurysms of the deep femoral artery should be treated without any delay.

  13. Topographic evidence of True Polar Wander on Enceladus

    NASA Astrophysics Data System (ADS)

    Tajeddine, R.; Soderlund, K. M.; Thomas, P.; Helfenstein, P.; Schenk, P.; Hedman, M. M.; Burns, J. A.

    2015-12-01

    The peculiar presence of the active hotspot at Enceladus' south pole raises the question of whether it formed in situor if the satellite reoriented over time and moved the hotspot there from a different location. Here we extend a spherical harmonic reconstruction of Enceladus' shape to order 16 by combining Cassini limb profile data with the positions of a large, globally distributed collection of surface control points. We have discovered an aligned arrangement of deep topographic lows that define a circumglobal valley lying along a non-equatorial great circle across Enceladus' surface. In addition, we have found two antipodal basins located about 90 degrees from the great circle. We argue that these structures are evidence of True Polar Wander of an angle 75 to 90 degrees, where the great circle and the antipodal regions are remnants of old equator and poles, respectively. Modeling of heat transport in Enceladus' sub-surface ocean suggests that heat flux along the ice-ocean interface is strongest and weakest at high and low latitudes, respectively. The resulting basal melt/freeze distribution may produce latitudinal variations in ice shell thickness and density that can create the topographic depressions apparent at the surface through isostatic adjustment. Our hypothesis also agrees well with the surface geological features visible in Cassini images.

  14. True-personality-assisted self-awareness expert system

    SciTech Connect

    Laleuf, M.

    1988-01-01

    Based on psychoanalytic theory, the Who am I expert system explains in simple terms the individual's true personality, even it its unconscious or hidden aspects. Our overt personality traits are deeply rooted. The Who am I expert system gives access to an individual's primary personality, starting from his habitual everyday-life behavior: (1) describes the individual's basic personality, (2) explains this personality through the individual's deeply rooted experience and motivation, and (3) makes links with other people with a similar profile. The following are the primary features of the system: easy individual access, results in <20 minutes, and guaranteed confidentiality. Business applications include the following: (1) Individual training: Self-awareness improves a person's ability to fit in and to succeed within the group. (2) Communication: a homogeneous team has a better chance of success. (3) Human reliability: A close-knit team remains reliable even when faced with serious difficulties. (4) Recruitment: This technique enables the selection of individuals who will fit an existing homogeneous team. The system also enables a psychological diagnosis to be confirmed.

  15. Characterizing the True Background Corona with SDO/AIA

    NASA Technical Reports Server (NTRS)

    Napier, Kate; Winebarger, Amy; Alexander, Caroline

    2014-01-01

    Characterizing the nature of the solar coronal background would enable scientists to more accurately determine plasma parameters, and may lead to a better understanding of the coronal heating problem. Because scientists study the 3D structure of the Sun in 2D, any line of sight includes both foreground and background material, and thus, the issue of background subtraction arises. By investigating the intensity values in and around an active region, using multiple wavelengths collected from the Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory (SDO) over an eight-hour period, this project aims to characterize the background as smooth or structured. Different methods were employed to measure the true coronal background and create minimum intensity images. These were then investigated for the presence of structure. The background images created were found to contain long-lived structures, including coronal loops, that were still present in all of the wavelengths, 193 Angstroms,171 Angstroms,131 Angstroms, and 211 Angstroms. The intensity profiles across the active region indicate that the background is much more structured than previously thought.

  16. Genetic monandry in 6 viviparous species of true sea snakes.

    PubMed

    Lukoschek, Vimoksalehi; Avise, John C

    2011-01-01

    Using a suite of 10 highly variable microsatellite loci, we conducted genetic paternity analyses for 76 embryos in the broods of 12 pregnant females representing 6 viviparous species of true sea snakes (Hydrophis clade) in the family Elapidae. To our surprise, we uncovered no evidence for multiple paternity within any of the clutches despite the fact that the genetic markers showed high intraspecific heterozygosities and as many as 20 conspecific alleles per locus. This outcome stands in sharp contrast to the rather high (but also variable) frequency of multiple paternity previously reported in many other reptilian species. However, because our study appears to be the first assessment of genetic parentage for any sea snake species (and indeed for any member of the elapid clade), we can only speculate as to whether this apparent monandry by females is a broader phylogenetic characteristic of elapid snakes or whether it might relate somehow to the sea snakes' peculiar lifestyle that uniquely combines viviparity with a marine existence.

  17. Blood flow estimation in gastroscopic true-color images

    NASA Astrophysics Data System (ADS)

    Jacoby, Raffael S.; Herpers, Rainer; Zwiebel, Franz M.; Englmeier, Karl-Hans

    1995-05-01

    The assessment of blood flow in the gastrointestinal mucosa might be an important factor for the diagnosis and treatment of several diseases such as ulcers, gastritis, colitis, or early cancer. The quantity of blood flow is roughly estimated by computing the spatial hemoglobin distribution in the mucosa. The presented method enables a practical realization by calculating approximately the hemoglobin concentration based on a spectrophotometric analysis of endoscopic true-color images, which are recorded during routine examinations. A system model based on the reflectance spectroscopic law of Kubelka-Munk is derived which enables an estimation of the hemoglobin concentration by means of the color values of the images. Additionally, a transformation of the color values is developed in order to improve the luminance independence. Applying this transformation and estimating the hemoglobin concentration for each pixel of interest, the hemoglobin distribution can be computed. The obtained results are mostly independent of luminance. An initial validation of the presented method is performed by a quantitative estimation of the reproducibility.

  18. Sulfur-Rich Rocks and Dirt (True Color)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    NASA's Mars Rover Spirit has been analyzing sulfur-rich rocks and surface materials in the 'Columbia Hills' in Gusev Crater on Mars. This image of a very soft, nodular, layered rock nicknamed 'Peace' in honor of Martin Luther King Jr. shows a 4.5-centimeter-wide (1.8-inch-wide) hole Spirit ground into the surface with the rover's rock abrasion tool. The high sulfur content of the rock measured by Spirit's alpha particle X-ray spectrometer and its softness measured by the abrasion tool are probably evidence of past alteration by water. Spirit's panoramic camera took this image on martian day, or sol, 381 (Jan. 27, 2005). The image represents the panoramic camera team's best current attempt at generating a true color view of what this scene would look like if viewed by a human on Mars. The image was generated from a combination of six calibrated, left-eye Pancam images acquired through filters ranging from 430-nanometer to 750-nanometer wavelengths.

  19. ["True neurologic thoracic outlet syndrome" -- anatomical features and electrophysiological long-term follow-up of lateral thenar atrophy].

    PubMed

    Hug, U; Jung, F J; Guggenheim, M; Wedler, V; Burg, D; Künzi, W

    2006-02-01

    Atrophies of the intrinsic muscles of the hand are considered to be a typical symptom of the "true neurologic" form of thoracic outlet syndrome (TOS). The classical form of this entity was described as early as 1970, consisting of a cervical rib or a prolonged transverse process of C7, complete with a fibrous band to the first thoracic rib, resulting in atrophy of the intrinsic muscles of the hand. All our TOS patients presenting with such atrophy displayed anatomical findings consistent with this definition. Based on this observation, the TOS classification currently in clinical use, which differentiates between "disputed" and "true neurologic" subgroups of the neurologic form, is reviewed. In all cases of "true neurologic TOS" with atrophy of the intrinsic muscles of the hand, the lateral thenar muscles are affected first. We present the electrophysiological long-term results of such thenar atrophies of seven patients with eight operated extremities after brachial plexus decompression. The amplitude of the neurographically measured potential over the opponens pollicis and the abductor pollicis brevis muscle, respectively, was defined as quantitative parameter for muscles atrophy. Neither distinct reinnervation nor progressive denervation was evident in any of the cases after a follow-up period, on average, of more than five years post surgery. These findings are in conflict with clinical observations reporting a major postoperative improvement of the motor deficits.

  20. Culture and Achievement Motivation

    ERIC Educational Resources Information Center

    Maehr, Martin L.

    1974-01-01

    A framework is suggested for the cross-cultural study of motivation that stresses the importance of contextual conditions in eliciting achievement motivation and emphasizes cultural relativity in the definition of the concept. (EH)

  1. Achieving Salary Equity

    ERIC Educational Resources Information Center

    Nevill, Dorothy D.

    1975-01-01

    Three techniques are outlined for use by higher education institutions to achieve salary equity: salary prediction (using various statistical procedures), counterparting (comparing salaries of persons of similar rank), and grievance procedures. (JT)

  2. Improving Dose Determination Accuracy in Nonstandard Fields of the Varian TrueBeam Accelerator

    NASA Astrophysics Data System (ADS)

    Hyun, Megan A.

    In recent years, the use of flattening-filter-free (FFF) linear accelerators in radiation-based cancer therapy has gained popularity, especially for hypofractionated treatments (high doses of radiation given in few sessions). However, significant challenges to accurate radiation dose determination remain. If physicists cannot accurately determine radiation dose in a clinical setting, cancer patients treated with these new machines will not receive safe, accurate and effective treatment. In this study, an extensive characterization of two commonly used clinical radiation detectors (ionization chambers and diodes) and several potential reference detectors (thermoluminescent dosimeters, plastic scintillation detectors, and alanine pellets) has been performed to investigate their use in these challenging, nonstandard fields. From this characterization, reference detectors were identified for multiple beam sizes, and correction factors were determined to improve dosimetric accuracy for ionization chambers and diodes. A validated computational (Monte Carlo) model of the TrueBeam(TM) accelerator, including FFF beam modes, was also used to calculate these correction factors, which compared favorably to measured results. Small-field corrections of up to 18 % were shown to be necessary for clinical detectors such as microionization chambers. Because the impact of these large effects on treatment delivery is not well known, a treatment planning study was completed using actual hypofractionated brain, spine, and lung treatments that were delivered at the UW Carbone Cancer Center. This study demonstrated that improperly applying these detector correction factors can have a substantial impact on patient treatments. This thesis work has taken important steps toward improving the accuracy of FFF dosimetry through rigorous experimentally and Monte-Carlo-determined correction factors, the validation of an important published protocol (TG-51) for use with FFF reference fields, and a

  3. Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines

    PubMed Central

    Cheng, Ben-Chung; Lee, Chih-Hsiung; Chang, Wen-Xiu

    2016-01-01

    Background. This study evaluated the association between achieving target chronic kidney disease-mineral and bone disorder (CKD-MBD) marker levels and mortality in Taiwanese hemodialysis (HD) patients. Target levels were based on the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Methods. We performed a retrospective medical record review of 1126 HD patients between 2009 and 2013. A logistic regression model was used to evaluate the relationship between achieving target marker levels and the risk for all-cause and cardiovascular (CV) mortality. Reference target ranges were 7.9 ≤ calcium (Ca) ≤ 9.9 mg/dL, 2.4 ≤ phosphate (P) ≤ 4.7 mg/dL, and 144 ≤ intact parathyroid hormone (iPTH) ≤ 648 pg/mL. Results. Achievement of target P levels was associated with a lower risk for all-cause mortality compared to achievement of either target Ca or iPTH levels. Achieving target P + iPTH levels (OR 1.32) was associated with a lower odds ratio for all-cause mortality compared to achieving target Ca + P (OR 1.66) and Ca + iPTH (OR 1.43) levels. Similar trends were observed for CV mortality risk. Conclusions. The present study demonstrated that achieving serum P levels within the KDIGO target range is the most important factor for lowering mortality in HD patients. PMID:28003998

  4. Hydrodynamic perception in true seals (Phocidae) and eared seals (Otariidae).

    PubMed

    Hanke, Wolf; Wieskotten, Sven; Marshall, Christopher; Dehnhardt, Guido

    2013-06-01

    Pinnipeds, that is true seals (Phocidae), eared seals (Otariidae), and walruses (Odobenidae), possess highly developed vibrissal systems for mechanoreception. They can use their vibrissae to detect and discriminate objects by direct touch. At least in Phocidae and Otariidae, the vibrissae can also be used to detect and analyse water movements. Here, we review what is known about this ability, known as hydrodynamic perception, in pinnipeds. Hydrodynamic perception in pinnipeds developed convergently to the hydrodynamic perception with the lateral line system in fish and the sensory hairs in crustaceans. So far two species of pinnipeds, the harbour seal (Phoca vitulina) representing the Phocidae and the California sea lion (Zalophus californianus) representing the Otariidae, have been studied for their ability to detect local water movements (dipole stimuli) and to follow hydrodynamic trails, that is the water movements left behind by objects that have passed by at an earlier point in time. Both species are highly sensitive to dipole stimuli and can follow hydrodynamic trails accurately. In the individuals tested, California sea lions were clearly more sensitive to dipole stimuli than harbour seals, and harbour seals showed a superior trail following ability as compared to California sea lions. Harbour seals have also been shown to derive additional information from hydrodynamic trails, such as motion direction, size and shape of the object that caused the trail (California sea lions have not yet been tested). The peculiar undulated shape of the harbour seals' vibrissae appears to play a crucial role in trail following, as it suppresses self-generated noise while the animal is swimming.

  5. True vertical validation in facial orthognathic surgery planning

    PubMed Central

    Ruiz-Navarro, Maria B.; Barrera-Mora, José M.; Llamas-Carreras, José M.; Puigdollers-Pérez, Andreu; Ayala-Puente, Jorge

    2013-01-01

    Objectives: To validate the effectiveness of the original standards of True Vertical (TV) Subnasal Line in orthognatic surgery planning. The present study evaluates the changes occurring in patients with skeletal Class II alterations programmed for orthognathic surgery with a view to improving their facial profile. Study design: We showed a series of black profiles (composed by a first control group of subjects with normal occlusion, and another two additional groups comprised patients before –Group 2- and after orthognatic surgical correction of Class II malocclusion -Group 3-) for three groups of observers (orthodontists, surgeons and laypeople). The facial images became black silhouettes in order to determine a series of parameters (including aesthetic assessment) by means of the observers. Their observation were assessed using a 5-point Likert scale. Results: The sample was composed of 52 profile’s subjects who were tested for a total of 72 observers. Aesthetic assessment yielded mean scores of 2.57, 1.67 and 2.46 for groups 1, 2 and 3, respectively. There was a statistically significant difference (p<0.001) between group 1 versus group 2. There were no significant differences in terms of observer assessment of aesthetics, with the exception of a wider perception range among the orthodontists. Regarding the studied profile measures, significant differences were recorded for point B’ and Pg’ (p<0.02) between groups 2 and 3 (i.e., pre- versus post-surgery). Conclusions: The results of our study suggest the subnasale vertical and sagittal measures of the lower third of the face are decisive in facial aesthetics, and therefore also for the planning of orthognathic surgery. Consequently, these aesthetic parameters can be used as an objective tool for the planning of orthodontic treatment. Key words:Facial profile, Class II, orthognathic surgery, cephalometric analysis, facial soft tissue, subnasale vertical. PMID:24455088

  6. True Density Prediction of Garlic Slices Dehydrated by Convection.

    PubMed

    López-Ortiz, Anabel; Rodríguez-Ramírez, Juan; Méndez-Lagunas, Lilia

    2016-01-01

    Physiochemical parameters with constant values are employed for the mass-heat transfer modeling of the air drying process. However, structural properties are not constant under drying conditions. Empirical, semi-theoretical, and theoretical models have been proposed to describe true density (ρp). These models only consider the ideal behavior and assume a linear relationship between ρp and moisture content (X); nevertheless, some materials exhibit a nonlinear behavior of ρp as a function of X with a tendency toward being concave-down. This comportment, which can be observed in garlic and carrots, has been difficult to model mathematically. This work proposes a semi-theoretical model for predicting ρp values, taking into account the concave-down comportment that occurs at the end of the drying process. The model includes the ρs dependency on external conditions (air drying temperature (Ta)), the inside temperature of the garlic slices (Ti ), and the moisture content (X) obtained from experimental data on the drying process. Calculations show that the dry solid density (ρs ) is not a linear function of Ta, X, and Ti . An empirical correlation for ρs is proposed as a function of Ti and X. The adjustment equation for Ti is proposed as a function of Ta and X. The proposed model for ρp was validated using experimental data on the sliced garlic and was compared with theoretical and empirical models that are available in the scientific literature. Deviation between the experimental and predicted data was determined. An explanation of the nonlinear behavior of ρs and ρp in the function of X, taking into account second-order phase changes, are then presented.

  7. Adding Seabed True Color to the Virtual Globe

    NASA Astrophysics Data System (ADS)

    Coplan, J.; Ryan, W. B.; Jenkins, C. J.; Lotti Bond, R.; Arko, R. A.

    2009-12-01

    Since the late 1940’s thousands of sediment cores have been extracted from the global ocean floor. In the process of describing these cores, the color of the sediment has often been recorded using the Munsell Soil color scheme. This observation has been routine for >14,000 cores in the Deep-Sea Sample Repository at the Lamont-Doherty Earth Observatory of Columbia University. The text descriptions were parsed and processed to extract the Munsell code for the uppermost sediment layer in each core. The code was then converted to red, green, blue triplets so that a dot at the location of each seabed sample could be colored in map view on a computer monitor. The sediment color has also been extracted from thousands of other samples in the dbSEABED database and USGS databases. Sediment color is influenced by many parameters, but most notably by the carbonate content, the level of dissolved oxygen in the bottom water and the burial rate. The carbonate content has been measured in a substantial subset of the core tops, and a global grid at 1 degree node spacing is available to assist the interpolation of the seabed color onto a uniform grid. The seabed dissolved oxygen content has also been gridded from physical oceanographic stations. Using these and other proxies (e.g., seafloor depth, slope, physiographic boundaries, carbonate lysocline, surface ocean productivity, seafloor age, etc.), we have begun to construct a comprehensive image of the seabed in its true color for our GeoMapApp and Virtual Ocean tiles. The color of the seabed will ultimately compliment the color of the land accomplished by JPL/NASA in their Blue Marble tile set. The steps taken, problems encountered and the preliminary results will be presented in the poster.

  8. E4 True and false color hot spot mosaic

    NASA Technical Reports Server (NTRS)

    1997-01-01

    True and false color views of Jupiter from NASA's Galileo spacecraft show an equatorial 'hotspot' on Jupiter. These images cover an area 34,000 kilometers by 11,000 kilometers (about 21,100 by 6,800 miles). The top mosaic combines the violet and near infrared continuum filter images to create an image similar to how Jupiter would appear to human eyes. Differences in coloration are due to the composition and abundances of trace chemicals in Jupiter's atmosphere. The bottom mosaic uses Galileo's three near-infrared wavelengths displayed in red, green, and blue) to show variations in cloud height and thickness. Bluish clouds are high and thin, reddish clouds are low, and white clouds are high and thick. The dark blue hotspot in the center is a hole in the deep cloud with an overlying thin haze. The light blue region to the left is covered by a very high haze layer. The multicolored region to the right has overlapping cloud layers of different heights. Galileo is the first spacecraft to distinguish cloud layers on Jupiter.

    North is at the top. The mosaic covers latitudes 1 to 10 degrees and is centered at longitude 336 degrees west. The smallest resolved features are tens of kilometers in size. These images were taken on December 17, 1996, at a range of 1.5 million kilometers (about 930,000 miles) by the Solid State Imaging camera system aboard Galileo. The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC.

    This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at: http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at: http:/ /www.jpl.nasa.gov/galileo/sepo.

  9. Larval nervous systems: true larval and precocious adult.

    PubMed

    Nielsen, Claus

    2015-02-15

    The apical organ of ciliated larvae of cnidarians and bilaterians is a true larval organ that disappears before or at metamorphosis. It appears to be sensory, probably involved in metamorphosis, but knowledge is scant. The ciliated protostome larvae show ganglia/nerve cords that are retained as the adult central nervous system (CNS). Two structures can be recognized, viz. a pair of cerebral ganglia, which form the major part of the adult brain, and a blastoporal (circumblastoporal) nerve cord, which becomes differentiated into a perioral loop, paired or secondarily fused ventral nerve cords and a small perianal loop. The anterior loop becomes part of the brain. This has been well documented through cell-lineage studies in a number of spiralians, and homologies with similar structures in the ecdysozoans are strongly indicated. The deuterostomes are generally difficult to interpret, and the nervous systems of echinoderms and enteropneusts appear completely enigmatic. The ontogeny of the chordate CNS can perhaps be interpreted as a variation of the ontogeny of the blastoporal nerve cord of the protostomes, and this is strongly supported by patterns of gene expression. The presence of 'deuterostomian' blastopore fates both in an annelid and in a mollusk, which are both placed in families with the 'normal' spiralian gastrulation type, and in the chaetognaths demonstrates that the chordate type of gastrulation could easily have evolved from the spiralian type. This indicates that the latest common ancestor of the deuterostomes was very similar to the latest common pelago-benthic ancestor of the protostomes as described by the trochaea theory, and that the neural tube of the chordates is morphologically ventral.

  10. Does a Claims Diagnosis of Autism Mean a True Case?

    ERIC Educational Resources Information Center

    Burke, James P.; Jain, Anjali; Yang, Wenya; Kelly, Jonathan P.; Kaiser, Marygrace; Becker, Laura; Lawer, Lindsay; Newschaffer, Craig J.

    2014-01-01

    The purpose of this study was to validate autism spectrum disorder cases identified through claims-based case identification algorithms against a clinical review of medical charts. Charts were reviewed for 432 children who fell into one of the three following groups: (a) more than or equal to two claims with an autism spectrum disorder diagnosis…

  11. Commissioning measurements for photon beam data on three TrueBeam linear accelerators, and comparison with Trilogy and Clinac 2100 linear accelerators.

    PubMed

    Beyer, Gloria P

    2013-01-07

    in the profile shapes at a distance greater than 20 cm from the central axis, and this was more notable for the 15 MV energy. Output factor differences were found primarily at the ends of the field size spectrum, with observed differences of less than 2% as compared to the other linear accelerators. The TrueBeam's output factor varied less as a function of field size than the output factors for the previous models; this was especially true for the 6 MV. Photon beam data were found to be reproducible between different TrueBeam linear accelerators well within the accepted clinical tolerance of ± 2%. The results indicate reproducibility in the TrueBeam machine head construction and a potential for beam matching between these types of linear accelerators. Photon beam data (6 MV and 15 MV) from the Trilogy and Clinac 2100 showed several similarities and some small variations when compared to the same data measured on the TrueBeam linear accelerator. The differences found could affect small field data and also very large field sizes in beam matching considerations between the TrueBeam and previous linear accelerator models from the same manufacturer, but should be within the accepted clinical tolerance for standard field sizes and standard treatments.

  12. True Local Recurrences after Breast Conserving Surgery have Poor Prognosis in Patients with Early Breast Cancer

    PubMed Central

    Sarsenov, Dauren; Ilgun, Serkan; Ordu, Cetin; Alco, Gul; Bozdogan, Atilla; Elbuken, Filiz; Nur Pilanci, Kezban; Agacayak, Filiz; Erdogan, Zeynep; Eralp, Yesim; Dincer, Maktav

    2016-01-01

    Background: This study was aimed at investigating clinical and histopathologic features of ipsilateral breast tumor recurrences (IBTR) and their effects on survival after breast conservation therapy. Methods: 1,400 patients who were treated between 1998 and 2007 and had breast-conserving surgery (BCS) for early breast cancer (cT1-2/N0-1/M0) were evaluated. Demographic and pathologic parameters, radiologic data, treatment, and follow-up related features of the patients were recorded. Results: 53 patients (3.8%) had IBTR after BCS within a median follow-up of 70 months. The mean age was 45.7 years (range, 27-87 years), and 22 patients (41.5%) were younger than 40 years. 33 patients (62.3%) had true recurrence (TR) and 20 were classified as new primary (NP). The median time to recurrence was shorter in TR group than in NP group (37.0 (6-216) and 47.5 (11-192) months respectively; p = 0.338). Progesterone receptor positivity was significantly higher in the NP group (p = 0.005). The overall 5-year survival rate in the NP group (95.0%) was significantly higher than that of the TR group (74.7%, p < 0.033). Multivariate analysis showed that younger age (<40 years), large tumor size (>20 mm), high grade tumor and triple-negative molecular phenotype along with developing TR negatively affected overall survival (hazard ratios were 4.2 (CI 0.98-22.76), 4.6 (CI 1.07-13.03), 4.0 (CI 0.68-46.10), 6.5 (CI 0.03-0.68), and 6.5 (CI 0.02- 0.80) respectively, p < 0.05). Conclusions: Most of the local recurrences after BCS in our study were true recurrences, which resulted in a poorer outcome as compared to new primary tumors. Moreover, younger age (<40), large tumor size (>2 cm), high grade, triple negative phenotype, and having true recurrence were identified as independent prognostic factors with a negative impact on overall survival in this dataset of patients with recurrent breast cancer. In conjunction with a more intensive follow-up program, the role of adjuvant therapy

  13. Continuous angle steering of an optically- controlled phased array antenna based on differential true time delay constituted by micro-optical components.

    PubMed

    Wang, Jian; Hou, Peipei; Cai, Haiwen; Sun, Jianfeng; Wang, Shunan; Wang, Lijuan; Yang, Fei

    2015-04-06

    We propose an optically controlled phased array antenna (PAA) based on differential true time delay constructed optical beamforming network (OBFN). Differential true time delay is realized by stack integrated micro-optical components. Optically-controlled angle steering of radio frequency (RF) beams are realized and demonstrated by this configuration. Experimental results demonstrate that OBFN based PAA can accomplish RF-independent broadband beam steering without beam squint effect and can achieve continuous angle steering. In addition, multi-beams for different steering angles are acquired synchronously.

  14. Immunoglobulin M for Acute Infection: True or False?

    PubMed Central

    2016-01-01

    Immunoglobulin M (IgM) tests have clear clinical utility but also suffer disproportionately from false-positive results, which in turn can lead to misdiagnoses, inappropriate therapy, and premature closure of a diagnostic workup. Despite numerous reports in the literature, many clinicians and laboratorians remain unaware of this issue. In this brief review, a series of virology case examples is presented. However, a false-positive IgM can occur with any pathogen. Thus, when an accurate diagnosis is essential for therapy, prognosis, infection control, or public health, when the patient is sick enough to be hospitalized, or when the clinical or epidemiologic findings do not fit, IgM detection should not be accepted as a stand-alone test. Rather, whenever possible, the diagnosis should be confirmed by other means, including testing of serial samples and the application of additional test methods. PMID:27193039

  15. Existential crises in two religious patients: Vicissitudes of faith and the emergence of the true self.

    PubMed

    Fattori, Lucia; Secchi, Cesare

    2015-08-01

    The authors present two clinical cases involving an existential crisis which led the patients to lose what had been the foundation in their lives, their faith. Although the therapeutic settings differ--the first patient had a few psychotherapy sessions following a psychotic episode with a mystical background, while the second was in the final stage of analytic treatment - the authors highlight how in both clinical cases a loss of faith becomes a total and urgent crisis of the Self. The fracture which ensues seems to generate an intense engagement of the body which, paradoxically during a loss of faith, induces an experience of ecstasy of the kind that has traditionally been reported. In the first case the experience of ecstasy was lived first-hand by the patient who thereafter redefined the psychotic breakdown as a "moment of truth"; whereas the second patient, through a deep projective identification, induces an eerie countertransferential feeling of 'metaphysical' shortfall in the agnostic psychoanalyst, triggering bewilderment, physical discomfort and awe in him. In both cases the authors believe that the notable somatic involvement may be correlated to a potentially profound and unprecedented contact with the True Self.

  16. Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study

    PubMed Central

    Qian, Xiaohua; Tan, Hua; Zhang, Jian; Liu, Keqin; Yang, Tielin; Wang, Maode; Debinskie, Waldemar; Zhao, Weilin; Chan, Michael D.; Zhou, Xiaobo

    2016-01-01

    The diagnosis for pseudoprogression (PsP) and true tumor progression (TTP) of GBM is a challenging task in clinical practices. The purpose of this study is to identify potential genetic biomarkers associated with PsP and TTP based on the clinical records, longitudinal imaging features, and genomics data. We are the first to introduce the radiogenomics approach to identify candidate genes for PsP and TTP of GBM. Specifically, a novel longitudinal sparse regression model was developed to construct the relationship between gene expression and imaging features. The imaging features were extracted from tumors along the longitudinal MRI and provided diagnostic information of PsP and TTP. The 33 candidate genes were selected based on their association with the imaging features, reflecting their relation with the development of PsP and TTP. We then conducted biological relevance analysis for 33 candidate genes to identify the potential biomarkers, i.e., Interferon regulatory factor (IRF9) and X-ray repair cross-complementing gene (XRCC1), which were involved in the cancer suppression and prevention, respectively. The IRF9 and XRCC1 were further independently validated in the TCGA data. Our results provided the first substantial evidence that IRF9 and XRCC1 can serve as the potential biomarkers for the development of PsP and TTP. PMID:27421136

  17. True Polar Wander of Enceladus From Topographic Data

    NASA Astrophysics Data System (ADS)

    Tajeddine, Radwan; Soderlund, Krista M.; Thomas, Peter C.; Helfenstein, Paul; Hedman, Matthew M.; Burns, Joseph A.; Schenk, Paul M.

    2016-10-01

    Besides the relative motion of lithospheric plates, the Earth as a whole moves with respect to its rotation pole, as shown by paleomagnetic, astrometric and geodetic measurements [1]. Such so-called true polar wander (TPW) occurs because our planet's moments of inertia change temporally owing to internal thermal convection and to the redistribution of surficial mass during ice ages. Thus, to conserve angular momentum while losing rotational energy, Earth's axis of maximum moment of inertia aligns with its spin axis. Theoreticians suspect similar reorientations of other celestial bodies but supporting evidence is fragmentary, at best [2]. Here we report the discovery of a global series of topographic lows on Saturn's satellite Enceladus indicating that this synchronously locked moon has undergone reorientation by ~55°. We use improved topographic data from spherical harmonic expansion of Cassini limb [3,4,5] and stereogrammetric [5,6,7] measurements to characterize regional topography over the surface of Enceladus. We identify a group of nearly antipodal basins orthogonal to a topographic basin chain tracing a non-equatorial circumglobal belt across Enceladus' surface. We argue that the belt and the antipodal regions are fossil remnants of old equator and poles, respectively. These lows are argued to arise from isostasic compensation [7,8] with their pattern reflecting variations in internal dynamics of the ice shell. Our hypothesis is consistent with many geological features visible in Cassini images [9].References:[1] Mitrovica, J.X. & Wahr, Annual Review of Earth and Planetary Sciences, 39, 577-616 (2011).[2] Matsuyama, I. et al. Annual Review of Earth and Planetary Sciences, 42, 605-634 (2014).[3] Thomas, P.C. et al. Icarus, 190, 573-584 (2007).[4] Thomas, P.C. Icarus, 208, 395-401 (2010).[5] Thomas, P.C. et al. Icarus, 264, 37-47 (2016).[6] Edwards, K. Photogrammetric Engineering and Remote Sensing, 53, 1219-1222 (1987).[7] Schenk, P.M. & McKinnon, W. B

  18. SALT and Spelling Achievement.

    ERIC Educational Resources Information Center

    Nelson, Joan

    A study investigated the effects of suggestopedic accelerative learning and teaching (SALT) on the spelling achievement, attitudes toward school, and memory skills of fourth-grade students. Subjects were 20 male and 28 female students from two self-contained classrooms at Kennedy Elementary School in Rexburg, Idaho. The control classroom and the…

  19. Iowa Women of Achievement.

    ERIC Educational Resources Information Center

    Ohrn, Deborah Gore, Ed.

    1993-01-01

    This issue of the Goldfinch highlights some of Iowa's 20th century women of achievement. These women have devoted their lives to working for human rights, education, equality, and individual rights. They come from the worlds of politics, art, music, education, sports, business, entertainment, and social work. They represent Native Americans,…

  20. Schools Achieving Gender Equity.

    ERIC Educational Resources Information Center

    Revis, Emma

    This guide is designed to assist teachers presenting the Schools Achieving Gender Equity (SAGE) curriculum for vocational education students, which was developed to align gender equity concepts with the Kentucky Education Reform Act (KERA). Included in the guide are lesson plans for classes on the following topics: legal issues of gender equity,…

  1. Achieving Peace through Education.

    ERIC Educational Resources Information Center

    Clarken, Rodney H.

    While it is generally agreed that peace is desirable, there are barriers to achieving a peaceful world. These barriers are classified into three major areas: (1) an erroneous view of human nature; (2) injustice; and (3) fear of world unity. In a discussion of these barriers, it is noted that although the consciousness and conscience of the world…

  2. Explorations in achievement motivation

    NASA Technical Reports Server (NTRS)

    Helmreich, Robert L.

    1982-01-01

    Recent research on the nature of achievement motivation is reviewed. A three-factor model of intrinsic motives is presented and related to various criteria of performance, job satisfaction and leisure activities. The relationships between intrinsic and extrinsic motives are discussed. Needed areas for future research are described.

  3. Increasing Male Academic Achievement

    ERIC Educational Resources Information Center

    Jackson, Barbara Talbert

    2008-01-01

    The No Child Left Behind legislation has brought greater attention to the academic performance of American youth. Its emphasis on student achievement requires a closer analysis of assessment data by school districts. To address the findings, educators must seek strategies to remedy failing results. In a mid-Atlantic district of the Unites States,…

  4. Appraising Reading Achievement.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    To determine quality sequence in pupil progress, evaluation approaches need to be used which guide the teacher to assist learners to attain optimally. Teachers must use a variety of procedures to appraise student achievement in reading, because no one approach is adequate. Appraisal approaches might include: (1) observation and subsequent…

  5. Cognitive Processes and Achievement.

    ERIC Educational Resources Information Center

    Hunt, Dennis; Randhawa, Bikkar S.

    For a group of 165 fourth- and fifth-grade students, four achievement test scores were correlated with success on nine tests designed to measure three cognitive functions: sustained attention, successive processing, and simultaneous processing. This experiment was designed in accordance with Luria's model of the three functional units of the…

  6. Graders' Mathematics Achievement

    ERIC Educational Resources Information Center

    Bond, John B.; Ellis, Arthur K.

    2013-01-01

    The purpose of this experimental study was to investigate the effects of metacognitive reflective assessment instruction on student achievement in mathematics. The study compared the performance of 141 students who practiced reflective assessment strategies with students who did not. A posttest-only control group design was employed, and results…

  7. Achieving All Our Ambitions

    ERIC Educational Resources Information Center

    Hartley, Tricia

    2009-01-01

    National learning and skills policy aims both to build economic prosperity and to achieve social justice. Participation in higher education (HE) has the potential to contribute substantially to both aims. That is why the Campaign for Learning has supported the ambition to increase the proportion of the working-age population with a Level 4…

  8. Improving Educational Achievement.

    ERIC Educational Resources Information Center

    New York University Education Quarterly, 1979

    1979-01-01

    This is a slightly abridged version of the report of the National Academy of Education panel, convened at the request of HEW Secretary Joseph Califano and Assistant Secretary for Education Mary F. Berry, to study recent declines in student achievement and methods of educational improvement. (SJL)

  9. The Achievement Club

    ERIC Educational Resources Information Center

    Rogers, Ibram

    2009-01-01

    When Gabrielle Carpenter became a guidance counselor in Northern Virginia nine years ago, she focused on the academic achievement gap and furiously tried to close it. At first, she was compelled by tremendous professional interest. However, after seeing her son lose his zeal for school, Carpenter joined forces with other parents to form an…

  10. Achievement in Problem Solving

    ERIC Educational Resources Information Center

    Friebele, David

    2010-01-01

    This Action Research Project is meant to investigate the effects of incorporating research-based instructional strategies into instruction and their subsequent effect on student achievement in the area of problem-solving. The two specific strategies utilized are the integration of manipulatives and increased social interaction on a regular basis.…

  11. Essays on Educational Achievement

    ERIC Educational Resources Information Center

    Ampaabeng, Samuel Kofi

    2013-01-01

    This dissertation examines the determinants of student outcomes--achievement, attainment, occupational choices and earnings--in three different contexts. The first two chapters focus on Ghana while the final chapter focuses on the US state of Massachusetts. In the first chapter, I exploit the incidence of famine and malnutrition that resulted to…

  12. Advancing Student Achievement

    ERIC Educational Resources Information Center

    Walberg, Herbert J.

    2010-01-01

    For the last half century, higher spending and many modern reforms have failed to raise the achievement of students in the United States to the levels of other economically advanced countries. A possible explanation, says Herbert Walberg, is that much current education theory is ill informed about scientific psychology, often drawing on fads and…

  13. NCLB: Achievement Robin Hood?

    ERIC Educational Resources Information Center

    Bracey, Gerald W.

    2008-01-01

    In his "Wall Street Journal" op-ed on the 25th of anniversary of "A Nation At Risk", former assistant secretary of education Chester E. Finn Jr. applauded the report for turning U.S. education away from equality and toward achievement. It was not surprising, then, that in mid-2008, Finn arranged a conference to examine the…

  14. Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias

    PubMed Central

    Salama, Abdulgabar

    2015-01-01

    Summary Autoimmune haemolytic anaemias (AIHAs) are well-characterized disorders. They can be differentiated from one another and from other non-immune haemolytic anaemias by clinical, laboratory and serological testing. However, several misleading clinical presentations and/or serological findings may result in misinterpretation, delay and/or misdiagnosis. Such failures are avoidable by adequate clinical and serological experience of the responsible physicians and serologists or, at least, by an optimised bidirectional communication. As long as this has not been achieved, unpleasant failures are to be expected. A true diagnosis of AIHA can neither be verified by clinical nor serological findings alone. Thus, a collective clinical and serological picture remains obligatory for fulfilling the criteria of optimal diagnosis and therapy. Ultimately, the majority of pioneer scientific and practical work in this field stems from scientists who were simultaneously involved in both the clinic and serology. PMID:26696799

  15. True Vertigo Patients in Emergency Department; an Epidemiologic Study

    PubMed Central

    Shahrami, Ali; Norouzi, Mehdi; Kariman, Hamid; Hatamabadi, Hamid Reza; Arhami Dolatabadi, Ali

    2016-01-01

    Introduction: Vertigo prevalence is estimated to be 1.8% among young adults and more than 30% in the elderly. 13-38% of the referrals of patients over 65 years old in America are due to vertigo. Vertigo does not increase the risk of mortality but it can affect the patient’s quality of life. Therefore, this study was designed to evaluate the epidemiologic characteristics of vertigo patients referred to the emergency department (ED). Methods: In this 6-month retrospective cross-sectional study, the profiles of all vertigo patients referred to the ED of Imam Hossein Hospital, Tehran, Iran, from October 2013 to March 2014 were evaluated. Demographic data and baseline characteristics of the patients were recorded and then patients were divided into central and peripheral vertigo. The correlation of history and clinical examination with vertigo type was evaluated and screening performance characteristics of history and clinical examination in differentiating central and peripheral vertigo were determined. Results: 379 patients with the mean age of 50.69 ± 11.94 years (minimum 18 and maximum 86) were enrolled (58.13% female). There was no sex difference in vertigo incidence (p = 0.756). A significant correlation existed between older age and increase in frequency of central cases (p < 0.001). No significant difference was detected between the treatment protocols regarding ED length of stay (p = 0.72). There was a significant overlap between the initial diagnosis and the final decision based on imaging and neurologist’s final opinion (p < 0.001). In the end, 361 (95.3%) patients were discharged from ED, while 18 were disposed to the neurology ward. No case of mortality was reported. Conclusion: Sensitivity and specificity of history and clinical examination in differentiating central and peripheral vertigo were 99 (95% CI: 57-99) and 99 (95% CI: 97-99), respectively PMID:26862546

  16. Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension.

    PubMed

    Fadl Elmula, Fadl Elmula M; Hoffmann, Pavel; Larstorp, Anne C; Fossum, Eigil; Brekke, Magne; Kjeldsen, Sverre E; Gjønnæss, Eyvind; Hjørnholm, Ulla; Kjaer, Vibeke N; Rostrup, Morten; Os, Ingrid; Stenehjem, Aud; Høieggen, Aud

    2014-05-01

    We aimed to investigate for the first time the blood pressure (BP)-lowering effect of renal sympathetic denervation (RDN) versus clinically adjusted drug treatment in true treatment-resistant hypertension (TRH) after excluding patients with confounding poor drug adherence. Patients with apparent TRH (n=65) were referred for RDN, and those with secondary and spurious hypertension (n=26) were excluded. TRH was defined as office systolic BP (SBP) >140 mm Hg, despite maximally tolerated doses of ≥3 antihypertensive drugs including a diuretic. In addition, ambulatory daytime SBP >135 mm Hg after witnessed intake of antihypertensive drugs was required, after which 20 patients had normalized BP and were excluded. Patients with true TRH were randomized and underwent RDN (n=9) performed with Symplicity Catheter System versus clinically adjusted drug treatment (n=10). The study was stopped early for ethical reasons because RDN had uncertain BP-lowering effect. Office SBP and diastolic BP in the drug-adjusted group changed from 160±14/88±13 mm Hg (±SD) at baseline to 132±10/77±8 mm Hg at 6 months (P<0.0005 and P=0.02, SBP and diastolic BP, respectively) and in the RDN group from 156±13/91±15 to 148±7/89±8 mm Hg (P=0.42 and P=0.48, SBP and diastolic BP, respectively). SBP and diastolic BP were significantly lower in the drug-adjusted group at 6 months (P=0.002 and P=0.004, respectively), and absolute changes in SBP were larger in the drug-adjusted group (P=0.008). Ambulatory BPs changed in parallel to office BPs. Our data suggest that adjusted drug treatment has superior BP lowering effects compared with RDN in patients with true TRH. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT01673516.

  17. A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates at a National Reference Laboratory.

    PubMed

    Johnson-Davis, Kamisha L; Sadler, Aaron J; Genzen, Jonathan R

    2016-03-01

    Urine drug screens are commonly performed to identify drug use or monitor adherence to drug therapy. The purpose of this retrospective study was to evaluate the true positive and false positive rates of one of our in-house urine drug screen panels. The urine drugs of abuse panel studied consists of screening by immunoassay then positive immunoassay results were confirmed by mass spectrometry. Reagents from Syva and Microgenics were used for the immunoassay screen. The screen was performed on a Beckman AU5810 random access automated clinical analyzer. The percent of true positives for each immunoassay was determined. Agreement with previously validated GC-MS or LC-MS-MS confirmatory methods was also evaluated. There were 8,825 de-identified screening results for each of the drugs in the panel, except for alcohol (N = 2,296). The percent of samples that screened positive were: 10.0% for amphetamine/methamphetamine/3,4-methylenedioxy-methamphetamine (MDMA), 12.8% for benzodiazepines, 43.7% for opiates (including oxycodone) and 20.3% for tetrahydrocannabinol (THC). The false positive rate for amphetamine/methamphetamine was ∼14%, ∼34% for opiates (excluding oxycodone), 25% for propoxyphene and 100% for phencyclidine and MDMA immunoassays. Based on the results from this retrospective study, the true positive rate for THC drug use among adults were similar to the rate of illicit drug use in young adults from the 2013 National Survey; however, our positivity rate for cocaine was higher than the National Survey.

  18. Cosmetic appreciation of lateralization of peripheral facial palsy: 'preference for left or right, true or mirror image?'.

    PubMed

    Pouwels, Sjaak; Ingels, Koen; van Heerbeek, Niels; Beurskens, Carien

    2014-09-01

    There have been several studies in the past depicting asymmetry in 'normal' human faces. Evidence supports the fact that the right hemisphere is superior in the recognition of emotions expressed by the human face and indicates a right hemispheric specialization for processing emotional information. The primary aim of this study is to determine whether there is a difference in cosmetic appreciation of a left peripheral facial palsy compared to a right peripheral facial palsy? Pictures of patients with a facial palsy with House-Brackmann II-VI were reversed as a mirror image and offered as a pair of pictures, together with the true image. Forty-two patients and 24 medical professionals familiar with facial palsy were asked to choose the most attractive photograph. The primary 'end' point was the most attractive side in the pictures chosen by medical professionals and patients. The secondary 'end' points consisted of the preferences for the mirror or true image, and influences of the House-Brackmann score and age. Medical professionals preferred the photographs from patients with a right and left peripheral facial palsy (PFP) in, respectively, a mean of 44 % (41-48 %) and 56 % (52-59 %) of the pictures (p = 0.02). When comparing mirror and true image, patients with a left-sided facial palsy chose their mirror and true image as most attractive in 90 and 10 %, respectively (p < 0.05). Patients with a right-sided facial palsy chose their mirror and true image in 30 and 70 %, respectively (p > 0.05). Subanalysis of patients with a PFP House-Brackmann score V and VI showed that medical professionals did not have a significant preference for a left nor right-sided facial palsy. Patients with a left-sided facial palsy chose their mirror image in all cases and patients with a right-sided palsy chose their mirror and true image in resp. 33 and 67 %. The House-Brackmann score (p = 0.52) and age (p = 0.73) of the patients did not influence preferences. This study, demonstrating

  19. Gusev Rocks Solidified from Lava (Approximate True Color)

    NASA Technical Reports Server (NTRS)

    2006-01-01

    to identify rocks and features investigated by Spirit during the Chinese New Year celebration period. In ancient Chinese myth, FuYi was the first great emperor and lived in the east. He explained the theory of 'Yin' and 'Yang' to his people, invented the net to catch fish, was the first to use fire to cook food, and invented a musical instrument known as the 'Se' to accompany his peoples' songs and dances. Other rocks and features are being informally named for Chinese gods, warriors, inventors, and scientists, as well as rivers, lakes, and mountains.

    Spirit took this image on the rover's Martian day, or sol, 731 (Jan. 23, 2006). This is an approximate true color rendering combining images taken with the Pancam's 750-nanometer, 530-nanometer and 430-nanometer filters.

  20. Supercontinents, True Polar Wander, and Paleogeography of the Slave Craton

    NASA Astrophysics Data System (ADS)

    Mitchell, Ross Nelson

    The supercontinent cycle, which may have been operational throughout most of Earth history, describes not only the kinematics associated with the suturing and rifting of continents via plate tectonics but also the wholesale organization of mantle convection patterns, which has consequences for long-term geodynamics and true polar wander (TPW). Based on both newly acquired paleomagnetic data and regional or global syntheses, this thesis generates paleogeographic maps spanning 2 billion years and evaluates how such empirical constraints inform plate kinematics and TPW. Prior to Pangea, the latest supercontinent, paleomagnetism is the only quantitative method for reconstructing continents. Comparing high-quality data from continents considered central to Nuna, possibly Earth's first supercontinent, reconstructs the core of the hypothesized Paleo-Mesoproterozoic supercontinent for the first time. A global paleomagnetic synthesis spanning the past three supercontinents yields evidence for periods of oscillatory TPW following each supercontinent that can be used to infer a geometric pattern to supercontinent cycles and constrain absolute paleolongitude. Relative to post-Pangea oscillations, large-amplitude TPW is implied for older events if evidence for early TPW is to be believed. Possibly the last large (˜60°) TPW event occurred during the Cambrian explosion of animal life. A new detailed Early Cambrian magnetostratigraphy from the Amadeus Basin of Australia indicates a rapid Early Cambrian rotation of Gondwana, still permitting the possibility that at least one large-amplitude TPW event occurred in Phanerozoic time. Investigating earlier and even larger possible TPW episodes, several cases are identified where interpreting large paleomagnetic oscillations as TPW permits regional geologic interpretations to be honored. Allowing for only minor tectonic motion of Laurentia and large-scale TPW, large amounts of paleomagnetic motion observed can be reconciled with

  1. SU-E-T-341: DVH-Based Comparison of True 3D Measurements to a Delta4 System

    SciTech Connect

    Crockett, E; Oldham, M; Ren, L

    2015-06-15

    Purpose: Delta4 dosimetric software can be used to calculate DVH-based metrics for patient-specific quality assurance from measurements made by a Delta4 QA device. This study investigates the effectiveness of a novel transform method that transposes measurements made with a full-density 3D dosimeter onto patient anatomy, enabling the calculation of DVHs. This allows for DVH comparisons from the transformed dose distribution, which are based on true 3D measurements, to those from the Delta4 system, which are based on semi-3D measurements and interpolation. Methods: A double-arc VMAT treatment for a head-and-neck case was delivered to a 1kg PRESAGE 3D dosimeter inserted into a polyurethane head phantom. The dosimeter was readout using an in-house optical-CT scanner to gather full-density 3D dosimetric data. The transform method is achieved by multiplication of the measured doses with a “transformation matrix” which accounts for heterogeneities and differences in geometry between the patient and the phantom. The transformation matrix is a voxel-by-voxel division of the patient planned dose by the phantom planned dose, both calculated in the treatment planning system (Eclipse). The transformed distribution was then overlaid on the patient CT data, enabling the calculation of DVHs. The same VMAT treatment was delivered to the Delta4 phantom and DVH data was calculated using its associated software. Results: The transformed dose distribution showed good agreement with calculated patient values, determined by similarity in dose profiles between the two distributions and a 3D gamma index passing rate of 94.87% for 3%/3mm criteria. For every structure contained within the dosimeter volume, the transformed DVHs demonstrated better agreement than the Delta4 DVHs, when compared to the values calculated in the treatment planning system. Conclusion: The coupled technique of full-density 3D dose measurements and the presented transform method enables clinical patient

  2. Faculty achievement tracking tool.

    PubMed

    Pettus, Sarah; Reifschneider, Ellen; Burruss, Nancy

    2009-03-01

    Faculty development and scholarship is an expectation of nurse educators. Accrediting institutions, such as the Commission on Collegiate Nursing Education, the National League for Nursing Accrediting Commission, and the Higher Learning Commission, all have criteria regarding faculty achievement. A faculty achievement tracking tool (FATT) was developed to facilitate documentation of accreditation criteria attainment. Based on criteria from accrediting organizations, the roles that are addressed include scholarship, service, and practice. Definitions and benchmarks for the faculty as an aggregate are included. Undergoing reviews from different accrediting organizations, the FATT has been used once for accreditation of the undergraduate program and once for accreditation of the graduate program. The FATT is easy to use and has become an excellent adjunct for the preparation for accreditation reports. In addition, the FATT may be used for yearly evaluations, advancement, and merit.

  3. Project ACHIEVE final report

    SciTech Connect

    1997-06-13

    Project ACHIEVE was a math/science academic enhancement program aimed at first year high school Hispanic American students. Four high schools -- two in El Paso, Texas and two in Bakersfield, California -- participated in this Department of Energy-funded program during the spring and summer of 1996. Over 50 students, many of whom felt they were facing a nightmare future, were given the opportunity to work closely with personal computers and software, sophisticated calculators, and computer-based laboratories -- an experience which their regular academic curriculum did not provide. Math and science projects, exercises, and experiments were completed that emphasized independent and creative applications of scientific and mathematical theories to real world problems. The most important outcome was the exposure Project ACHIEVE provided to students concerning the college and technical-field career possibilities available to them.

  4. Oral lesion classification using true-color images

    NASA Astrophysics Data System (ADS)

    Chodorowski, Artur; Mattsson, Ulf; Gustavsson, Tomas

    1999-05-01

    The aim of the study was to investigate effective image analysis methods for the discrimination of two oral lesions, oral lichenoid reactions and oral leukoplakia, using only color information. Five different color representations (RGB, Irg, HSI, I1I2I3 and La*b*) were studied and their use for color analysis of mucosal images evaluated. Four common classifiers (Fisher's linear discriminant, Gaussian quadratic, kNN-Nearest Neighbor and Multilayer Perceptron) were chosen for the evaluation of classification performance. The feature vector consisted of the mean color difference between abnormal and normal regions extracted from digital color images. Classification accuracy was estimated using resubstitution and 5-fold crossvalidation methods. The best classification results were achieved in HSI color system and using linear discriminant function. In total, 70 out of 74 (94.6%) lichenoid reactions and 14 out of 20 (70.0%) of leukoplakia were correctly classified using only color information.

  5. Endovascular Management of True Renal Arterial Aneurysms: Results from a Single Centre

    SciTech Connect

    Chung, Raymond; Touska, Philip; Morgan, Robert; Belli, Anna-Maria

    2016-01-15

    PurposeTo report a single centre’s experience of the endovascular treatment of renal arterial aneurysms, including techniques and outcomes.Materials and MethodsThis is a retrospective analysis of true renal arterial aneurysms (TRAAs) treated using endovascular techniques over a period of 12 years and 10 months. The clinical presentations, aneurysm characteristics, endovascular techniques and outcomes are reported.ResultsThere were nine TRAA cases with a mean aneurysm size of 21.0 mm, located at the main renal arterial bifurcation in all cases. Onyx{sup ®} was used as the embolic agent of choice (88.9 % cases), with concurrent balloon remodelling. The overall primary technical success rate was 100 %. Repeat intervention was carried out in 1 case, secondary to reperfusion >8 years post-initial treatment. Long-term clinical follow-up was available in 55.6 % of cases (mean 29.8 months; range 3.3–90.1 months). Early post-procedural renal function, as measured by serum creatinine, remained within the normal reference range. Renal parenchymal loss post-embolisation was ≤20 % in 77.8 % of cases, as estimated on imaging. Minor complications included non-target embolization of Onyx{sup ®} with no clinical sequelae (n = 1), transient pain requiring only oral analgesia with no prolongation of hospital stay (n = 2). No major complications occurred as a consequence of embolisation.ConclusionEndovascular therapy is an effective and safe primary therapy for TRAA with high success rate and low morbidity, supplanting surgery as primary therapy. Current experience in the use of Onyx{sup ®} in TRAA is primarily limited to individual case reports, and this represents the largest case series of Onyx{sup ®}-treated TRAAs to date.

  6. Identifying Technology Barriers to the Realization of True Microrobots and Nanorobots for Military Application by 2035

    DTIC Science & Technology

    2010-01-01

    ELA-606 Short Research Paper 13-2251 1 Identifying Technology Barriers to the Realization of True Microrobots and Nanorobots for Military...concepts of “true” microrobot and nanorobot use in military applications; “true,” meaning that the robots are of micrometer and nanometer proportions...respectively. The main goal of this research is to identify key technological barriers to the development of true microrobots and nanorobots

  7. True and False DRM Memories: Differences Detected with an Implicit Task.

    PubMed

    Marini, Maddalena; Agosta, Sara; Mazzoni, Giuliana; Barba, Gianfranco Dalla; Sartori, Giuseppe

    2012-01-01

    Memory is prone to illusions. When people are presented with lists of words associated with a non-presented critical lure, they produce a high level of false recognitions (false memories) for non-presented related stimuli indistinguishable, at the explicit level, from presented words (DRM paradigm). We assessed whether true and false DRM memories can be distinguished at the implicit level by using the autobiographical IAT (aIAT), a novel method based on indirect measures that permits to detect true autobiographical events encoded in the respondent's mind/brain. In our experiment, after a DRM task participants performed two aIATs: the first aimed at testing implicit memory for presented words (true-memories aIAT) and the second aimed at evaluating implicit memory for critical lures (false-memories aIAT). Specifically, the two aIATs assessed the association of presented words and critical lures with the logical dimension "true." Results showed that the aIAT detected a greater association of presented words than critical lures with the logical dimension "true." This result indicates that although true and false DRM memories are indistinguishable at the explicit level a different association of the true and false DRM memories with the logical dimension "true" can be detected at the implicit level, and suggests that the aIAT may be a sensitive instrument to detect differences between true and false DRM memories.

  8. Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light

    PubMed Central

    Liu, Yan; Lai, Puxiang; Ma, Cheng; Xu, Xiao; Grabar, Alexander A.; Wang, Lihong V.

    2015-01-01

    Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques—for example, time-reversed ultrasonically encoded (TRUE) optical focusing—were developed. The speeds of these techniques, however, were limited to no greater than 1 Hz, preventing them from in vivo applications. Here we improve the speed of optical focusing deep inside scattering media by two orders of magnitude, and focus diffuse light inside a dynamic scattering medium having a speckle correlation time as short as 5.6 ms, typical of living tissue. By imaging a target, we demonstrate the first focusing of diffuse light inside a dynamic scattering medium containing living tissue. Since the achieved focusing speed approaches the tissue decorrelation rate, this work is an important step towards in vivo deep tissue noninvasive optical imaging, optogenetics and photodynamic therapy. PMID:25556918

  9. True molecular solutions of natural cellulose in the binary ionic liquid-containing solvent mixtures.

    PubMed

    Rein, Dmitry M; Khalfin, Rafail; Szekely, Noemi; Cohen, Yachin

    2014-11-04

    Evidence is presented for the first time of true molecular dissolution of cellulose in binary mixtures of common polar organic solvents with ionic liquid. Cryogenic transmission electron microscopy, small-angle neutron-, X-ray- and static light scattering were used to investigate the structure of cellulose solutions in mixture of dimethyl formamide and 1-ethyl-3-methylimidazolium acetate. Structural information on the dissolved chains (average molecular weight ∼ 5 × 10(4)g/mol; gyration radius ∼ 36 nm, persistence length ∼ 4.5 nm), indicate the absence of significant aggregation of the dissolved chains and the calculated value of the second virial coefficient ∼ 2.45 × 10(-2)mol ml/g(2) indicates that this solvent system is a good solvent for cellulose. More facile dissolution of cellulose could be achieved in solvent mixtures that exhibit the highest electrical conductivity. Highly concentrated cellulose solution in pure ionic liquid (27 wt.%) prepared according to novel method, utilizing the rapid evaporation of a volatile co-solvent in binary solvent mixtures at superheated conditions, shows insignificant cellulose molecular aggregation.

  10. Does choice of estimators influence conclusions from true metabolizable energy feeding trials?

    USGS Publications Warehouse

    Sherfy, M.H.; Kirkpatrick, R.L.; Webb, K.E.

    2005-01-01

    True metabolizable energy (TME) is a measure of avian dietary quality that accounts for metabolic fecal and endogenous urinary energy losses (EL) of non-dietary origin. The TME is calculated using a bird fed the test diet and an estimate of EL derived from another bird (Paired Bird Correction), the same bird (Self Correction), or several other birds (Group Mean Correction). We evaluated precision of these estimators by using each to calculate TME of three seed diets in blue-winged teal (Anas discors). The TME varied by <2% among estimators for all three diets, and Self Correction produced the least variable TMEs for each. The TME did not differ between estimators in nine paired comparisons within diets, but variation between estimators within individual birds was sufficient to be of practical consequence. Although differences in precision among methods were slight, Self Correction required the lowest sample size to achieve a given precision. Feeding trial methods that minimize variation among individuals have several desirable properties, including higher precision of TME estimates and more rigorous experimental control. Consequently, we believe that Self Correction is most likely to accurately represent nutritional value of food items and should be considered the standard method for TME feeding trials. ?? Dt. Ornithologen-Gesellschaft e.V. 2005.

  11. Ultra-compact optical true time delay device for wideband phased array radars.

    SciTech Connect

    Spahn, Olga Blum; Rabb, David J.; Cowan, William D.; McCray, David L.; Rowe, Delton, J.; Flannery, Martin R.; Yi, Allen Y.; Ho, James G.; Anderson, Betty Lise

    2010-02-01

    An ultra-compact optical true time delay device is demonstrated that can support 112 antenna elements with better than six bits of delay in a volume 16-inch x 5-inch x 4-inch including the box and electronics. Free-space beams circulate in a White cell, overlapping in space to minimize volume. The 18 mirrors are slow-tool diamond turned on two substrates, one at each end, to streamline alignment. Pointing accuracy of better than 10 {micro}rad is achieved, with surface roughness {approx}45 nm rms. A MEMS tip-style mirror array selects among the paths for each beam independently, requiring {approx}100 {micro}s to switch the whole array. The micromirrors have 1.4{sup o} tip angle and three stable states (east, west, and flat). The input is a fiber-and-microlens array, whose output spots are re-imaged multiple times in the White cell, striking a different area of the single MEMS chip in each of 10 bounces. The output is converted to RF by an integrated InP wideband optical combiner detector array. Delays were accurate to within 4% (shortest delay) to 0.03% (longest mirror train). The fiber-to-detector insertion loss is 7.82 dB for the shortest delay path.

  12. True-Time-Delay Adaptive Array Processing Using Photorefractive Crystals

    NASA Astrophysics Data System (ADS)

    Kriehn, G. R.; Wagner, K.

    Radio frequency (RF) signal processing has proven to be a fertile application area when using photorefractive-based, optical processing techniques. This is due to a photorefractive material's capability to record gratings and diffract off these gratings with optically modulated beams that contain a wide RF bandwidth, and include applications such as the bias-free time-integrating correlator [1], adaptive signal processing, and jammer excision, [2, 3, 4]. Photorefractive processing of signals from RF antenna arrays is especially appropriate because of the massive parallelism that is readily achievable in a photorefractive crystal (in which many resolvable beams can be incident on a single crystal simultaneously—each coming from an optical modulator driven by a separate RF antenna element), and because a number of approaches for adaptive array processing using photorefractive crystals have been successfully investigated [5, 6]. In these types of applications, the adaptive weight coefficients are represented by the amplitude and phase of the holographic gratings, and many millions of such adaptive weights can be multiplexed within the volume of a photorefractive crystal. RF modulated optical signals from each array element are diffracted from the adaptively recorded photorefractive gratings (which can be multiplexed either angularly or spatially), and are then coherently combined with the appropriate amplitude weights and phase shifts to effectively steer the angular receptivity pattern of the antenna array toward the desired arriving signal. Likewise, the antenna nulls can also be rotated toward unwanted narrowband jammers for extinction, thereby optimizing the signal-to-interference-plus-noise ratio.

  13. Updates and achievements in virology.

    PubMed

    Buonaguro, Franco M; Campadelli-Fiume, Gabriella; De Giuli Morghen, Carlo; Palù, Giorgio

    2010-07-01

    The 4th European Congress of Virology, hosted by the Italian Society for Virology, attracted approximately 1300 scientists from 46 countries worldwide. It also represented the first conference of the European Society for Virology, which was established in Campidoglio, Rome, Italy in 2009. The main goal of the meeting was to share research activities and results achieved in European virology units/institutes and to strengthen collaboration with colleagues from both western and developing countries. The worldwide representation of participants is a testament to the strength and attraction of European virology. The 5-day conference brought together the best of current virology; topics covered all three living domains (bacteria, archaea and eucarya), with special sessions on plant and veterinary virology as well as human virology, including two oral presentations on mimiviruses. The conference included five plenary sessions, 31 workshops, one hepatitis C virus roundtable, ten special workshops and three poster sessions, as well as 45 keynote lectures, 191 oral presentations and 845 abstracts. Furthermore, the Gesellschaft fur Virologie Loeffler-Frosch medal award was given to Peter Vogt for his long-standing career and achievements; the Gardner Lecture of the European Society for Clinical Virology was presented by Yoshihiro Kawaoka, and the Pioneer in Virology Lecture of the Italian Society for Virology was presented by Ulrich Koszinowski.

  14. True facets of TB diagnosis in 2012: Hypes and realities

    PubMed Central

    2012-01-01

    Tuberculosis takes a heavy toll of ~5000 lives every day from the disease; responsible for the 86% of DALY burden. Despite having drugs to treat TB efficiently, we have failed to control the disease. Mycobacterium tuberculosis has exploited it to their advantage evolving with multiple mutations making it resistant to first-line and second-line drugs. Most of the high-burden countries are low-medium income countries, their national TB program (NTP) still use sputum smear microscopy as the tool of diagnosis. Many new molecular tools are emerging, but confuse the larger TB clinical scientific community at the NTPs. Coherent information need to be disseminated, encouraging TB scientific community to generate evidences within NTPs assessing new tools through critical analyses in terms of value addition and cost benefit before considering rolling out in the program. It is also imperative that the scientific community need to have an open mind to use different tools in the right permutation and combination than being exclusive of one another. This article portrays an overview of the diagnostics landscape in 2012 with pros and cons of different tools to be able to generate a step-wise algorithm for optimal exploitation of the tools within available resources in each of the settings. PMID:24265909

  15. Comparison of desired radiographic advancement distance and true advancement distance required for patellar tendon-tibial plateau angle reduction to the ideal 90° in dogs by use of the modified Maquet technique.

    PubMed

    Pillard, Paul; Livet, Veronique; Cabon, Quentin; Bismuth, Camille; Sonet, Juliette; Remy, Denise; Fau, Didier; Carozzo, Claude; Viguier, Eric; Cachon, Thibaut

    2016-12-01

    OBJECTIVE To evaluate the validity of 2 radiographic methods for measurement of the tibial tuberosity advancement distance required to achieve a reduction in patellar tendon-tibial plateau angle (PTA) to the ideal 90° in dogs by use of the modified Maquet technique (MMT). SAMPLE 24 stifle joints harvested from 12 canine cadavers. PROCEDURES Radiographs of stifle joints placed at 135° in the true lateral position were used to measure the required tibial tuberosity advancement distance with the conventional (A(M)) and correction (A(E)) methods. The MMT was used to successively advance the tibial crest to A(M) and A(E). Postoperative PTA was measured on a mediolateral radiograph for each advancement measurement method. If none of the measurements were close to 90°, the advancement distance was modified until the PTA was equal to 90° within 0.1°, and the true advancement distance (TA) was measured. Results were used to determine the optimal commercially available size of cage implant that would be used in a clinical situation. RESULTS Median A(M) and A(E) were 10.6 mm and 11.5 mm, respectively. Mean PTAs for the conventional and correction methods were 93.4° and 92.3°, respectively, and differed significantly from 90°. Median TA was 13.5 mm. The A(M) and A(E) led to the same cage size recommendations as for TA for only 1 and 4 stifle joints, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Both radiographic methods of measuring the distance required to advance the tibial tuberosity in dogs led to an under-reduction in postoperative PTA when the MMT was used. A new, more accurate radiographic method needs to be developed.

  16. Fibular free flap reconstruction of the "true" lateral mandibular defect.

    PubMed

    Anthony, J P; Foster, R D; Kaplan, M J; Singer, M I; Pogrel, M A

    1997-02-01

    The purpose of this study was to determine the role of the fibular free flap in reconstructing lateral segmental defects of the mandible. Over the past 5 1/2 years, 17 consecutive patients underwent reconstruction of their lateral mandible with the fibular free flap. Patients included 12 men and 5 women, the mean age was 54 years (range, 29-76 years), and the mean length of the mandibular defect was 6.3 cm (range, 2.5-9 cm). The majority of patients with tumors (54%) were treated for recurrence and 92% received radiation to the operative field. The mean operative time to perform the microsurgery and bone plating was 4 hours. Postoperative morbidity occurred in 3 patients (18%) (plate fracture, malocclusion, orocutaneous fistula). Five patients (29%) required leg donor site skin grafting. Donor site morbidity included a minor cellulitis, a transient neuropraxia, and one case of leg swelling. None required additional surgery for donor complications. Thus far, 71% of the patients have received dental rehabilitation and 35% had osseointegrated implants placed in their bone flap. Eighty-two percent of the patients achieved both good or excellent aesthetic and functional results. Sixteen patients (94%) tolerate at least a soft diet and 65% are on a regular diet. Five patients developed tumor recurrence an average of 9 months postoperatively with a mean survival of 21 months. This study demonstrates that the fibular free flap is highly reliable for reconstructing the lateral mandible in a single stage, with low overall morbidity, and provides for excellent dental and speech rehabilitation. For most patients, the fibular free flap should be considered for lateral mandibular reconstruction even in those patients with a limited life expectancy.

  17. Bone induction by surface-double-modified true bone ceramics in vitro and in vivo.

    PubMed

    Li, Jingfeng; Zheng, Qixin; Guo, Xiaodong; Zou, Zhenwei; Liu, Yudong; Lan, Shenghui; Chen, Liaobin; Deng, Yu

    2013-06-01

    True bone ceramic (TBC), obtained by twice sintering fresh bovine cancellous bone at high temperatures, is an osteoconductive and bioactive bone substitute material that exhibits excellent biocompatibility with hard tissue. The authors have previously synthesized a novel BMP-2-related peptide, P24, and found that it could enhance the osteoblastic differentiation of cells. The objective of the present study was to construct a double-modified TBC via mineralization into simulated body fluid and P24 incorporation for enhanced bone formation. In vitro experiments revealed that surface mineralization-modified (SMM) TBC scaffolds demonstrated efficiency for sustained release of P24. The P24/SMM-TBC composite exhibited increased osteogenic activity by cell adhesion rate determination, MTT assay, alkaline phosphatase staining, and calcium nodule staining with alizarin red compared with SMM-TBC and TBC. In vivo studies showed that the P24/SMM-TBC composite scaffold promoted significant bone defect repair, in marked contrast to stand-alone SMM-TBC and TBC, based on the results of radiographic evaluation and histological examination. These findings indicate that SMM-TBC is a good scaffold for the controlled release of P24 and that the P24/SMM-TBC composite could improve the adhesion, proliferation and differentiation of cells and repair bone defects. The double-modified P24/SMM-TBC composite biomaterial shows potential for clinical application in bone tissue engineering.

  18. The journal impact factor: how to interpret its true value and importance.

    PubMed

    Grzybowski, Andrzej

    2009-02-01

    In 1955, Garfield suggested that the number of references could be used to measure the "impact" of a journal, but the term "impact factor" was introduced in 1963 by Garfield and Sher. The primary goal of impact factor analysis was to improve the management of library journal collections. Single-parameter measurements of the quality of a journal article have become increasingly popular as a substitute for scientific quality. The simplicity of its counting system and convenience of its use are significant benefits. Probably for these reasons, funding bodies, academic authorities, and some governments began using the impact factor to guide decisions about allocating grants, awarding appointments and academic degrees, and defining scientific policy. The journal impact factor, which is often recognized as a symbol of scientific prestige and relevance, can be, however, greatly influenced by the type of medical article (review vs original work), clinical specialty, and research. The true value and implications of the journal impact factor (JIF) are important to understand. It is critical to remember that JIF can be used only to evaluate journals. All comparisons should include only journals and never individuals or departments. Only similar journals (particularly those dedicated to the same scientific specialty) must be compared, because the value of the impact factor varies greatly by discipline.

  19. The "Clinical" Masters Degree.

    ERIC Educational Resources Information Center

    Perlman, Baron; Lane, Robert

    1981-01-01

    Discusses issues surrounding the clinical master's degree: the belief that the only true psychologist is a PhD, public confusion between doctoral and subdoctoral psychologists, training guidelines, role responsibility, employment, licensing and competency, accreditation, and supervision. Suggests an APA sponsored conference to discuss and resolve…

  20. Latent Variable Modeling of Cognitive Processes in True and False Recognition of Words: A Developmental Perspective

    ERIC Educational Resources Information Center

    Bouwmeester, Samantha; Verkoeijen, Peter P. J. L.

    2010-01-01

    The present study aimed at testing theoretical predictions of the fuzzy-trace theory about true and false recognition. The effects of semantic relatedness and study opportunity on true and false recognition of words from Deese, Roediger, McDermott lists (J. Deese, 1959; D. R. Read, 1996; H. L. Roediger & K. B. McDermott, 1995) were evaluated…

  1. An Evaluation of Forced-Choice and True-False Item Formats in Personality Assessment.

    ERIC Educational Resources Information Center

    Jackson, Douglas N.; And Others

    In a comparative evaluation of a standard true-false format for personality assessment and a forced-choice format, subjects from college residential units were assigned randomly to respond either to the forced-choice or standard true-false form of the Personality Research Form (PRF). All subjects also rated themselves and the members of their…

  2. Developmentally Invariant Dissociations in Children's True and False Memories: Not All Relatedness Is Created Equal

    ERIC Educational Resources Information Center

    Howe, Mark L.

    2006-01-01

    The role of categorical versus associative relations in 5-, 7-, and 11-year-old children's true and false memories was examined using the Deese--Roediger--McDermott (DRM) paradigm and categorized lists of pictures or words with or without category labels as primes. For true items, recall increased with age and categorized lists were better…

  3. Anxiety and the True Beginner-False Beginner Dynamic in Beginning French and Spanish Classes

    ERIC Educational Resources Information Center

    Frantzen, Diana; Magnan, Sally Sieloff

    2005-01-01

    This study considered true beginners and false beginners in first-semester university French and Spanish classes to: (a) determine whether true beginners and false beginners differ in anxiety, grades, and plans to continue language study; and (b) identify classroom factors that foster anxiety or comfort. Students completed a questionnaire that…

  4. The cortical basis of true memory and false memory for motion.

    PubMed

    Karanian, Jessica M; Slotnick, Scott D

    2014-02-01

    Behavioral evidence indicates that false memory, like true memory, can be rich in sensory detail. By contrast, there is fMRI evidence that true memory for visual information produces greater activity in earlier visual regions than false memory, which suggests true memory is associated with greater sensory detail. However, false memory in previous fMRI paradigms may have lacked sufficient sensory detail to recruit earlier visual processing regions. To investigate this possibility in the present fMRI study, we employed a paradigm that produced feature-specific false memory with a high degree of visual detail. During the encoding phase, moving or stationary abstract shapes were presented to the left or right of fixation. During the retrieval phase, shapes from encoding were presented at fixation and participants classified each item as previously "moving" or "stationary" within each visual field. Consistent with previous fMRI findings, true memory but not false memory for motion activated motion processing region MT+, while both true memory and false memory activated later cortical processing regions. In addition, false memory but not true memory for motion activated language processing regions. The present findings indicate that true memory activates earlier visual regions to a greater degree than false memory, even under conditions of detailed retrieval. Thus, the dissociation between previous behavioral findings and fMRI findings do not appear to be task dependent. Future work will be needed to assess whether the same pattern of true memory and false memory activity is observed for different sensory modalities.

  5. Samarium Hexaboride: The First True 3D Topological Insulator?

    NASA Astrophysics Data System (ADS)

    Wolgast, Steven G.

    systematic scratching or sanding results in a counter-intuitive increase in the electrical conduction due to the unique surface-conducting property of TIs, strengthening the building case for SmB 6's topological nature. This material is attractive as a TI because its bulk is fully insulating at a readily achieved 2 K, but it presents a large number of scientific mysteries and experimental challenges for future research.

  6. Achieving closure at Fernald

    SciTech Connect

    Bradburne, John; Patton, Tisha C.

    2001-02-25

    When Fluor Fernald took over the management of the Fernald Environmental Management Project in 1992, the estimated closure date of the site was more than 25 years into the future. Fluor Fernald, in conjunction with DOE-Fernald, introduced the Accelerated Cleanup Plan, which was designed to substantially shorten that schedule and save taxpayers more than $3 billion. The management of Fluor Fernald believes there are three fundamental concerns that must be addressed by any contractor hoping to achieve closure of a site within the DOE complex. They are relationship management, resource management and contract management. Relationship management refers to the interaction between the site and local residents, regulators, union leadership, the workforce at large, the media, and any other interested stakeholder groups. Resource management is of course related to the effective administration of the site knowledge base and the skills of the workforce, the attraction and retention of qualified a nd competent technical personnel, and the best recognition and use of appropriate new technologies. Perhaps most importantly, resource management must also include a plan for survival in a flat-funding environment. Lastly, creative and disciplined contract management will be essential to effecting the closure of any DOE site. Fluor Fernald, together with DOE-Fernald, is breaking new ground in the closure arena, and ''business as usual'' has become a thing of the past. How Fluor Fernald has managed its work at the site over the last eight years, and how it will manage the new site closure contract in the future, will be an integral part of achieving successful closure at Fernald.

  7. Dynamic phase-sensitive optical coherence elastography at a true kilohertz frame-rate

    NASA Astrophysics Data System (ADS)

    Singh, Manmohan; Wu, Chen; Liu, Chih-Hao; Li, Jiasong; Schill, Alexander; Nair, Achuth; Larin, Kirill V.

    2016-03-01

    Dynamic optical coherence elastography (OCE) techniques have rapidly emerged as a noninvasive way to characterize the biomechanical properties of tissue. However, clinical applications of the majority of these techniques have been unfeasible due to the extended acquisition time because of multiple temporal OCT acquisitions (M-B mode). Moreover, multiple excitations, large datasets, and prolonged laser exposure prohibit their translation to the clinic, where patient discomfort and safety are critical criteria. Here, we demonstrate the feasibility of noncontact true kilohertz frame-rate dynamic optical coherence elastography by directly imaging a focused air-pulse induced elastic wave with a home-built phase-sensitive OCE system. The OCE system was based on a 4X buffered Fourier Domain Mode Locked swept source laser with an A-scan rate of ~1.5 MHz, and imaged the elastic wave propagation at a frame rate of ~7.3 kHz. Because the elastic wave directly imaged, only a single excitation was utilized for one line scan measurement. Rather than acquiring multiple temporal scans at successive spatial locations as with previous techniques, here, successive B-scans were acquired over the measurement region (B-M mode). Preliminary measurements were taken on tissue-mimicking agar phantoms of various concentrations, and the results showed good agreement with uniaxial mechanical compression testing. Then, the elasticity of an in situ porcine cornea in the whole eye-globe configuration at various intraocular pressures was measured. The results showed that this technique can acquire a depth-resolved elastogram in milliseconds. Furthermore, the ultra-fast acquisition ensured that the laser safety exposure limit for the cornea was not exceeded.

  8. Contiguous autogenous transplant--nineteen years' clinical and radiographic follow-up: a case report.

    PubMed

    Sperling, I; Kozlovsky, A; Tal, H

    1994-08-01

    Contiguous autogenous transplant, also known as the bone-swaging procedure, is a technique aimed at regenerating lost periodontium. Clinical healing of bony defects after bone swaging has been satisfactory, but the relationship and mode of attachment between the bone graft and the root surface have not been fully investigated. A 19-year clinical and radiographic follow-up of a bony defect treated with the bone-swaging technique is presented. A significant coronal increase in bone height and a gain in clinical probing depth were achieved postsurgery and remained unchanged during the first 6 years. The long-term clinical and radiographic findings, however, indicated that the attachment developed at the root-bone interface may not have been a true attachment and may have been more vulnerable to pathogenic local agents. These observations may help the clinician to interpret the clinical and radiographic changes that occur in the area of a bony defect following the use of a bone graft.

  9. Achievement Goals and Achievement Emotions: A Meta-Analysis

    ERIC Educational Resources Information Center

    Huang, Chiungjung

    2011-01-01

    This meta-analysis synthesized 93 independent samples (N = 30,003) in 77 studies that reported in 78 articles examining correlations between achievement goals and achievement emotions. Achievement goals were meaningfully associated with different achievement emotions. The correlations of mastery and mastery approach goals with positive achievement…

  10. The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series.

    PubMed

    Chiang, Jaclyn; Wong, Elizabeth; Whatham, Andrew; Hennessy, Michael; Kalloniatis, Michael; Zangerl, Barbara

    2015-01-01

    Ophthalmic practitioners have to make a critical differential diagnosis in cases of an elevated optic nerve head. They have to discriminate between pseudopapilloedema (benign elevation of the optic nerve head) and true swelling of the optic nerve head. This decision has significant implications for appropriate patient management. Assessment of the optic disc prior to the advanced imaging techniques that are available today (particularly spectral domain optical coherence tomography and fundus autofluorescence), has mainly used diagnostic tools, such as funduscopy and retinal photography. As these traditional methods rely on the subjective assessment by the clinician, evaluation of the elevated optic nerve head to differentiate pseudopapilloedema from true swelling of the optic nerve head can be a challenge in clinical practice with patients typically referred for further neuroimaging investigation when the diagnosis is uncertain. The use of multimodal ocular imaging tools such as spectral domain optical coherence tomography, short wavelength fundus autofluorescence and ultrasonography, can potentially aid in the differentiation of pseudopapilloedema from true swelling of the optic nerve head, in conjunction with other clinical findings. By doing so, unnecessary patient costs and anxiety in the case of pseudopapilloedema can be reduced, and appropriate urgent referral and management in the case of true swelling of the optic nerve head can be initiated.

  11. SU-E-T-624: Portal Dosimetry Commissioning of Multiple (6) Varian TrueBeam Linacs Equipped with PortalVision DMI MV Imager

    SciTech Connect

    Weldon, M; DiCostanzo, D; Grzetic, S; Hessler, J

    2015-06-15

    Purpose: To show that a single model for Portal Domisetry (PD) can be established for beam-matched TrueBeam™ linacs that are equipped with the DMI imager (43×43cm effective area). Methods: Our department acquired 6 new TrueBeam™s, 4 “Slim” and 2 “Edge” models. The Slims were equipped with 6 and 10MV photons, and the Edges with 6MV. MLCs differed between the Slims and Edges (Millennium 120 vs HD-MLC respectively). PD model was created from data acquired using a single linac (Slim). This includes maximum field size profile, as well as output factors and acquired measured fluence using the DMI imager. All identical linacs were beam-matched, profiles were within 1% at maximum field size at a variety of depths. The profile correction file was generated from 40×40 profile acquired at 5cm depth, 95cm SSD, and was adjusted for deviation at the field edges and corners. The PD model and profile correction was applied to all six TrueBeam™s and imagers. A variety of jaw only and sliding window (SW) MLC test fields, as well as TG-119 and clinical SW and VMAT plans were run on each linac to validate the model. Results: For 6X and 10X, field by field comparison using 3mm/3% absolute gamma criteria passed 90% or better for all cases. This was also true for composite comparisons of TG-199 and clinical plans, matching our current department criteria. Conclusion: Using a single model per photon energy for PD for the TrueBeam™ equipped with a DMI imager can produce clinically acceptable results across multiple identical and matched linacs. It is also possible to use the same PD model despite different MLCs. This can save time during commissioning and software updates.

  12. Construction of Chained True Score Equipercentile Equatings under the Kernel Equating (KE) Framework and Their Relationship to Levine True Score Equating. Research Report. ETS RR-09-24

    ERIC Educational Resources Information Center

    Chen, Haiwen; Holland, Paul

    2009-01-01

    In this paper, we develop a new chained equipercentile equating procedure for the nonequivalent groups with anchor test (NEAT) design under the assumptions of the classical test theory model. This new equating is named chained true score equipercentile equating. We also apply the kernel equating framework to this equating design, resulting in a…

  13. Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Low- and Middle-Income Countries for Achieving the UNAIDS 90-90-90 Targets

    PubMed Central

    Adetokunboh, Olatunji; Uthman, Olalekan A.; Knowlton, Amy W.; Altice, Frederick L.; Schechter, Mauro; Galárraga, Omar; Geng, Elvin; Peltzer, Karl; Chang, Larry W.; Van Cutsem, Gilles; Jaffar, Shabbar S.; Ford, Nathan; Mellins, Claude A.; Remien, Robert H.; Mills, Edward J.

    2017-01-01

    Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low-and middle-income countries (LMICs). We systematically searched four electronic databases for all available randomized controlled trials (RCTs) and comparative cohort studies in LMICs comparing community versus health facility-based interventions. Relative risks (RRs) for pre-defined adherence, treatment engagement (linkage and retention in care), and relevant clinical outcomes were pooled using random effect models. Eleven cohort studies and eleven RCTs (N = 97,657) were included. Meta-analysis of the included RCTs comparing community- versus health facility-based interventions found comparable outcomes in terms of ART adherence (RR = 1.02, 95 % CI 0.99 to 1.04), virologic suppression (RR = 1.00, 95 % CI 0.98 to 1.03), and all-cause mortality (RR = 0.93, 95 % CI 0.73 to 1.18). The result of pooled analysis from the RCTs (RR = 1.03, 95 % CI 1.01 to 1.06) and cohort studies (RR = 1.09, 95 % CI 1.03 to 1.15) found that participants assigned to community-based interventions had statistically significantly higher rates of treatment engagement. Two studies found community-based ART delivery model either cost-saving or cost-effective. Community- versus facility-based models of ART delivery resulted in at least comparable outcomes for clinically stable HIV-infected patients on treatment in LMICs and are likely to be cost-effective. PMID:27475643

  14. Using contrast patterns between true complexes and random subgraphs in PPI networks to predict unknown protein complexes

    PubMed Central

    Liu, Quanzhong; Song, Jiangning; Li, Jinyan

    2016-01-01

    Most protein complex detection methods utilize unsupervised techniques to cluster densely connected nodes in a protein-protein interaction (PPI) network, in spite of the fact that many true complexes are not dense subgraphs. Supervised methods have been proposed recently, but they do not answer why a group of proteins are predicted as a complex, and they have not investigated how to detect new complexes of one species by training the model on the PPI data of another species. We propose a novel supervised method to address these issues. The key idea is to discover emerging patterns (EPs), a type of contrast pattern, which can clearly distinguish true complexes from random subgraphs in a PPI network. An integrative score of EPs is defined to measure how likely a subgraph of proteins can form a complex. New complexes thus can grow from our seed proteins by iteratively updating this score. The performance of our method is tested on eight benchmark PPI datasets and compared with seven unsupervised methods, two supervised and one semi-supervised methods under five standards to assess the quality of the predicted complexes. The results show that in most cases our method achieved a better performance, sometimes significantly. PMID:26868667

  15. Benefits of Reiki Therapy for a Severely Neutropenic Patient with Associated Influences on a True Random Number Generator

    PubMed Central

    Beem, Lance W.

    2011-01-01

    Abstract Background Reiki therapy is documented for relief of pain and stress. Energetic healing has been documented to alter biologic markers of illness such as hematocrit. True random number generators are reported to be affected by energy healers and spiritually oriented conscious awareness. Methods The patient was a then 54-year-old severely ill man who had hepatitis C types 1 and 2 and who did not improve with conventional therapy. He also suffered from obesity, the metabolic syndrome, asthma, and hypertension. He was treated with experimental high-dose interferon/riboviron therapy with resultant profound anemia and neutropenia. Energetic healing and Reiki therapy was administered initially to enhance the patient's sense of well-being and to relieve anxiety. Possible effects on the patient's absolute neutrophil count and hematocrit were incidentally noted. Reiki therapy was then initiated at times of profound neutropenia to assess its possible effect on the patient's absolute neutrophil count (ANC). Reiki and other energetic healing sessions were monitored with a true random number generator (RNG). Results Statistically significant relationships were documented between Reiki therapy, a quieting of the electronically created white noise of the RNG during healing sessions, and improvement in the patient's ANC. The immediate clinical result was that the patient could tolerate the high-dose interferon regimen without missing doses because of absolute neutropenia. The patient was initially a late responder to interferon and had been given a 5% chance of clearing the virus. He remains clear of the virus 1 year after treatment. Conclusions The association between changes in the RNG, Reiki therapy, and a patient's ANC is the first to the authors' knowledge in the medical literature. Future studies assessing the effects of energetic healing on specific biologic markers of disease are anticipated. Concurrent use of a true RNG may prove to correlate with the

  16. Ultimate DWDM format in fiber-true bit-parallel solitons on WDM beams

    NASA Technical Reports Server (NTRS)

    Yeh, C.; Bergman, L. A.

    2000-01-01

    Whether true solitons can exist on WDM beams (and in what form) is a question that is generally unknown. This paper will discuss an answer to this question and a demonstration of the bit-parallel WDM transmission.

  17. Steam Technical Brief: How to Calculate the True Cost of Steam

    SciTech Connect

    2010-06-25

    This BestPractice Steam Technical Brief helps you calculate the true cost of steam. Knowing the correct cost is important for many reasons and all of them have to do with improving the company's bottom line.

  18. Lifting Minority Achievement: Complex Answers. The Achievement Gap.

    ERIC Educational Resources Information Center

    Viadero, Debra; Johnston, Robert C.

    2000-01-01

    This fourth in a four-part series on why academic achievement gaps exist describes the Minority Achievement Committee scholars program at Shaker Heights High School in Cleveland, Ohio, a powerful antidote to the achievement gap between minority and white and Asian American students. It explains the need to break down stereotypes about academic…

  19. Achievement Motivation of Women: Effects of Achievement and Affiliation Arousal.

    ERIC Educational Resources Information Center

    Gama, Elizabeth Maria Pinheiro

    1985-01-01

    Assigned 139 Brazilian women to neutral, affiliation arousal, and achievement arousal conditions based on their levels of achievement (Ach) and affiliative (Aff) needs. Results of story analyses revealed that achievement arousal increased scores of high Ach subjects and that high Aff subjects obtained higher scores than low Aff subjects. (BL)

  20. Attitude Towards Physics and Additional Mathematics Achievement Towards Physics Achievement

    ERIC Educational Resources Information Center

    Veloo, Arsaythamby; Nor, Rahimah; Khalid, Rozalina

    2015-01-01

    The purpose of this research is to identify the difference in students' attitude towards Physics and Additional Mathematics achievement based on gender and relationship between attitudinal variables towards Physics and Additional Mathematics achievement with achievement in Physics. This research focused on six variables, which is attitude towards…

  1. The Impact of Reading Achievement on Overall Academic Achievement

    ERIC Educational Resources Information Center

    Churchwell, Dawn Earheart

    2009-01-01

    This study examined the relationship between reading achievement and achievement in other subject areas. The purpose of this study was to determine if there was a correlation between reading scores as measured by the Standardized Test for the Assessment of Reading (STAR) and academic achievement in language arts, math, science, and social studies…

  2. Re-entry into the true lumen from the subintimal space.

    PubMed

    Schneider, Peter A; Caps, Michael T; Nelken, Nicolas

    2013-08-01

    Endovascular reconstruction of the femoral and popliteal arteries is replacing femoral-popliteal bypass. This is made possible by subintimal recanalization to manage long chronic total occlusions. Re-entry into the true lumen is the most challenging step in this process. This article summarizes the techniques for re-entry into the true lumen in the superficial femoral and above- and below-the-knee popliteal arteries.

  3. Holographic optical elements (HOEs) for true-time delays aimed at phased-array antenna applications

    NASA Astrophysics Data System (ADS)

    Chen, Ray T.; Li, Richard L.

    1996-05-01

    True time-delay beam steering in optical domain for phased-array antenna application using multiplexed substrate guided wave propagation is introduced. Limitations of practical true- time-delays are discussed. Aspects on making holographic grating couplers are considered. Finally, experimental results on the generation of 25 GHz broadband microwave signals by optical heterodyne technique and 1-to-30 massive substrate guided wave optical fanout with an uniform fanout intensity distribution are presented.

  4. True Measures

    ERIC Educational Resources Information Center

    Cox, Ron

    2010-01-01

    Air filters perform an important function in commercial and institutional facilities. Because indoor air typically is two to five times more polluted than outdoor air, air filters are needed to remove respirable particles such as microorganisms, dust and allergens from the breathing air. In fact, air filters provide the primary defense for…

  5. True Blue

    ERIC Educational Resources Information Center

    Mattise, M. Christine

    2004-01-01

    Traditional interventions (small group, individual counseling, classroom guidance, parent conferences) were obviously having little or no effect to stop bullying among children. The bullies had stuck with their project relentlessly, using snide looks, vicious whispering and a systematic plan to totally isolate one child on the playground. These…

  6. True North

    ERIC Educational Resources Information Center

    Benson, Jo-Anne Mary

    2007-01-01

    For Americans wanting to explore beyond their frontiers, their neighbor to the north is an ideal destination. Much of Canada's population is concentrated near the shared border, mostly in Ontario and Quebec. While nature is an obvious draw, Canada's dynamic urban centers present their own sophisticated enticements, and the country's ten provinces…

  7. True Colors.

    ERIC Educational Resources Information Center

    Penn-Nabrit, Paula

    2003-01-01

    Presents the story of how institutionalized racism prompted one African American couple to home school their three sons, who 10 years later, found themselves at Ivy League schools. The move to home schooling came after the boys were expelled from a mostly white, private school for what the parents insisted were racial reasons, asserting that skin…

  8. True but not false memories are associated with the HTR2A gene.

    PubMed

    Zhu, Bi; Chen, Chuansheng; Loftus, Elizabeth F; Moyzis, Robert K; Dong, Qi; Lin, Chongde

    2013-11-01

    Previous research reported that serotonin receptor 2A gene (HTR2A) polymorphisms were associated with memory. However, it is unknown whether these genetic variants were associated with both true and false memories. The current study of 336 Han Chinese subjects tested 30 single nucleotide polymorphisms (SNPs) within the HTR2A gene for potential associations with true and false memories. False memories were assessed using the Deese-Roediger-McDermott (DRM) paradigm, in which people falsely remember semantically related (but unpresented) words. We found that 11 SNPs within the HTR2A gene were associated with true memory (p=0.000076-0.043). The associations between true memory and seven adjacent SNPs (i.e., rs1923888, rs1745837, rs9567739, rs3742279, rs655888, rs655854, and rs2296972) were still significant after multiple testing corrections. Haplotype-based association analysis revealed that, true memory was positively associated with haplotype A-C-C-G-C-T-A for these seven adjacent SNPs (p=0.000075), which was still significant after multiple testing correction. Only one SNP rs655854 was associated with false memory (p=0.023), and it was not significant after multiple testing correction. This study replicates, in an Asian population, that genetic variation in HTR2A is associated with episodic memory, and also suggests that this association is restricted to true memory.

  9. Validation study of the TrueAllele automated data review system.

    PubMed

    Kadash, Kristy; Kozlowski, Brian E; Biega, Lisa A; Duceman, Barry W

    2004-07-01

    The New York State Convicted Offender DNA Databank is the first U.S. lab to complete an internal validation of the TrueAllele expert data review system. TrueAllele is designed to assess short tandem repeat (STR) DNA data based on several key features such as peak height, shape, area, and position relative to a standard ladder and use this information to make accurate allele calls. The software then prioritizes the allele calls based on several user-defined rules. As a result, the user need only review low-quality data. The validation of this system consisted of an extensive optimization phase and a large concordance phase. During optimization, the rule settings were tailored to minimize the amount of high-quality data viewed by the user. In the concordance phase, a large dataset was typed in parallel with the ABI software Gene Scan and Genotyper (manual review) and TrueAllele (automated review) for comparison of allele calls and sample state assignment. Only one significant difference was discovered out of 2048 samples in the concordance study. In this case, TrueAllele revealed a spike in the profile that was interpreted as a DNA peak by the analyst in Genotyper. TrueAllele was designed to focus the review on poor data and to eliminate the need for complete reanalysis technical review. This validation project proved TrueAllele to be dependable for use at the NYS Convicted Offender DNA Databank.

  10. Chemical composition, true nutrient digestibility, and true metabolizable energy of novel pet food protein sources using the precision-fed cecectomized rooster assay.

    PubMed

    Deng, P; Utterback, P L; Parsons, C M; Hancock, L; Swanson, K S

    2016-08-01

    A wide variety of animal protein-based ingredients is commonly used in the pet food products. The raw ingredients and processing procedures used may greatly affect protein quality. Testing the quality of alternative protein sources is necessary and contributes to the sustainability of pet foods. The objective of this study was to test the chemical composition of 8 protein sources intended for use in dog and cat foods (calamari meal, pork peptone, alligator meal, lamb meal, venison meal, chicken meal, and 2 duck meals), and evaluate their true nutrient digestibility and nitrogen-corrected true ME (TMEn) using the precision-fed cecectomized rooster assay. Calamari meal and pork peptone had lower ash (4.4 and 3.6% of DM, respectively) but greater CP (88.1 and 80.5% of DM, respectively) and either greater or similar GE (5.6 and 5.3 kcal/g of DM, respectively) compared with alligator, lamb, venison, chicken, and duck meals (11.8 to 24.5% ash, 58.7 to 65.9% CP, and 4.6 to 5.3 kcal GE/g). Acid-hydrolyzed fat (AHF) was lower in calamari meal (8.7% of DM) compared with the other proteins tested (15.5-22.1% of DM). True nutrient digestibility was variable among the protein sources (52 to 79% of DM, 60 to 83% of OM, 78 to 92% of AHF, and 70 to 89% of GE) with pork peptone having the highest DM, AHF, and GE digestibility and calamari meal having the highest OM digestibility. True indispensable AA digestibility was highest for calamari meal, with all AA having a digestibility greater than 90%. Except for histidine, all indispensable AA had a digestibility over 85% for pork peptone. In contrast, true indispensable AA digestibility was lowest for lamb meal, with histidine having digestibility less than 70% and the other entire indispensable AA having digestibility between 72 and 88%. The TMEn of calamari meal (4.82 kcal/g DM and 86.9% of GE) was greater ( < 0.05) than the other protein sources. The lamb meal had the lowest TMEn value (3.12 kcal/g DM and 66.9% of GE), with others

  11. Meal replacements and fibre supplement as a strategy for weight loss. Proprietary PGX® meal replacement and PGX® fibre supplement in addition to a calorie-restricted diet to achieve weight loss in a clinical setting.

    PubMed

    Reichert, Ronald G; Reimer, Raylene A; Kacinik, Veronica; Pal, Sebely; Gahler, Roland J; Wood, Simon

    2013-01-01

    Meal replacements and viscous soluble fibre represent safe and sustainable aids for weight loss. Our purpose was to determine if PGX® meal replacements and PGX(®) fibre complex in combination with a calorie-restricted diet would aid in weight loss in a clinical setting. Fifty-two overweight and obese participants (49 women, 3 men; average age 47.1 years) with a mean body mass index (BMI) of 33.8 ± 6.4 kg/m(2) consumed 57 g of proprietary PGX® meal replacement product at breakfast and another 57 g at lunch for 12 weeks. In addition to the meal replacements, they were also asked to consume 5 g/day of PGX® fibre in the form of granules, powder or capsules together with 250 mlwater. A registered dietician recommended low-fat, low-glycaemic-index foods for snacks and the dinner menus such that each volunteer was consuming a total of 1200 kcal/day. All participants (n = 52) lost a significant amount of weight from baseline (-4.69 ± 3.73 kg), which was further reflected in the reductions in their waist (-7.11 ± 6.35 cm) and hip circumference (-5.59 ± 3.58 cm) over the 12-week study (p < 0.0001). BMI scores (n = 51) were reduced by 1.6 ± 1.4 kg/m(2). The use of PGX® meal replacements and PGX(®) fibre along with a controlled dietary caloric intake is of benefit for short-term weight loss.

  12. Achievements in Stratospheric Ozone Protection

    EPA Pesticide Factsheets

    This report describes achievements in protecting the ozone layer, the benefits of these achievements, and strategies involved (e.g., using alternatives to ozone-depleting substances, phasing out harmful substances, and creating partnerships).

  13. Students’ Achievement Goals, Learning-Related Emotions and Academic Achievement

    PubMed Central

    Lüftenegger, Marko; Klug, Julia; Harrer, Katharina; Langer, Marie; Spiel, Christiane; Schober, Barbara

    2016-01-01

    In the present research, the recently proposed 3 × 2 model of achievement goals is tested and associations with achievement emotions and their joint influence on academic achievement are investigated. The study was conducted with 388 students using the 3 × 2 Achievement Goal Questionnaire including the six proposed goal constructs (task-approach, task-avoidance, self-approach, self-avoidance, other-approach, other-avoidance) and the enjoyment and boredom scales from the Achievement Emotion Questionnaire. Exam grades were used as an indicator of academic achievement. Findings from CFAs provided strong support for the proposed structure of the 3 × 2 achievement goal model. Self-based goals, other-based goals and task-approach goals predicted enjoyment. Task-approach goals negatively predicted boredom. Task-approach and other-approach predicted achievement. The indirect effects of achievement goals through emotion variables on achievement were assessed using bias-corrected bootstrapping. No mediation effects were found. Implications for educational practice are discussed. PMID:27199836

  14. Visualization of swallowing using real-time TrueFISP MR fluoroscopy.

    PubMed

    Barkhausen, Jörg; Goyen, Mathias; von Winterfeld, Friederike; Lauenstein, Thomas; Arweiler-Harbeck, Diana; Debatin, Jörg F

    2002-01-01

    The aim of this study was to evaluate the ability of different real-time true fast imaging with steady precession (TrueFISP) sequences regarding their ability to depict the swallowing process and delineate oropharyngeal pathologies in patients with dysphagia. Real-time TrueFISP visualization of swallowing was performed in 8 volunteers and 6 patients with dysphagia using a 1.5 T scanner (Magnetom Sonata, Siemens, Erlangen Germany) equipped with high-performance gradients (amplitude 40 mT/m). Image quality of four different real-time TrueFISP sequences (TR 2.2-3.0 ms, TE 1.1-1.5 ms, matrix 63 x 128-135 x 256, field of view 250 mm(2), acquisition time per image 139-405 ms) was evaluated. Water, yoghurt, and semolina pudding were assessed as oral contrast agents. Functional exploration of the oropharyngeal apparatus was best possible using the fastest real-time TrueFISP sequence (TR 2.2 ms, TE 1.1 ms, matrix 63 x 128). Increased acquisition time resulted in blurring of anatomical structures. As the image contrast of TrueFISP sequences depends on T2/T1 properties, all tested foodstuff were well suited as oral contrast agents, but image quality was best using semolina pudding. Real-time visualization of swallowing is possible using real-time TrueFISP sequences in conjunction with oral contrast agents. For the functional exploration of swallowing high temporal resolution is more crucial than spatial resolution.

  15. Efficacy of a typing scheme for Campylobacter based on the combination of true and questionable CRISPR.

    PubMed

    de Cárdenas, Inés; Fernández-Garayzábal, José F; de la Cruz, María-Luisa; Domínguez, Lucas; Ugarte-Ruiz, María; Gómez-Barrero, Susana

    2015-12-01

    This study evaluates an improved scheme for Campylobacter genotyping based on the combination of true and questionable CRISPR (clustered regularly interspaced short palindromic repeats) elements. A total of 180 Campylobacter strains (Campylobacter jejuni n=93 and Campylobacter coli n=87), isolated from neck skin and caecal content of broilers, poultry meat and sewage water were analysed. Another 97 C. jejuni DNA samples from cases of human campylobacteriosis were assessed. Sixty-three genotypes were found in C. jejuni considering only true CRISPR, and 16 additional genotypes were identified when questionable CRISPR were also taken into account. Likewise in C. coli the number of genotypes increased from eight for only true CRISPR to 14 after including questionable CRISPR elements. The number of typeable C. jejuni and C. coli isolates was 115 (60.5%) and 17 (19.5%) respectively considering only true CRISPR. These percentages increased to 92.7% (n=176) and 39.1% (n=34) respectively when both true and questionable CRISPR were considered. 60.9% of the C. coli isolates were non-typeable by CRISPR due to the lack of any PCR amplifiable CRISPR loci, which raises questions about CRISPR analysis as an appropriate method for C. coli typing. However the assessment of true and questionable CRISPR has proved to be fairly useful for typing C. jejuni due to its high discriminatory power (Simpson's index=0.960) and typeability (92.7%) values. The results of the present work show that our genotyping method based on the combination of true and questionable CRISPR elements may be used as a suitable complementary tool to existing C. jejuni genotyping methods.

  16. The recombination mechanisms leading to amplified spontaneous emission at the true-green wavelength in CH3NH3PbBr3 perovskites

    NASA Astrophysics Data System (ADS)

    Priante, D.; Dursun, I.; Alias, M. S.; Shi, D.; Melnikov, V. A.; Ng, T. K.; Mohammed, O. F.; Bakr, O. M.; Ooi, B. S.

    2015-02-01

    We investigated the mechanisms of radiative recombination in a CH3NH3PbBr3 hybrid perovskite material using low-temperature, power-dependent (77 K), and temperature-dependent photoluminescence (PL) measurements. Two bound-excitonic radiative transitions related to grain size inhomogeneity were identified. Both transitions led to PL spectra broadening as a result of concurrent blue and red shifts of these excitonic peaks. The red-shifted bound-excitonic peak dominated at high PL excitation led to a true-green wavelength of 553 nm for CH3NH3PbBr3 powders that are encapsulated in polydimethylsiloxane. Amplified spontaneous emission was eventually achieved for an excitation threshold energy of approximately 350 μJ/cm2. Our results provide a platform for potential extension towards a true-green light-emitting device for solid-state lighting and display applications.

  17. [Clinical research=design*measurements*statistical analyses].

    PubMed

    Furukawa, Toshiaki

    2012-06-01

    A clinical study must address true endpoints that matter for the patients and the doctors. A good clinical study starts with a good clinical question. Formulating a clinical question in the form of PECO can sharpen one's original question. In order to perform a good clinical study one must have a knowledge of study design, measurements and statistical analyses: The first is taught by epidemiology, the second by psychometrics and the third by biostatistics.

  18. Semantic processes leading to true and false memory formation in schizophrenia

    PubMed Central

    Paz-Alonso, Pedro M.; Ghetti, Simona; Ramsay, Ian; Solomon, Marjorie; Yoon, Jong; Carter, Cameron S.; Ragland, J. Daniel

    2013-01-01

    Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits are not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under “standard” instructions and the other half under explicit “relational processing” instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit “relational processing” instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients’ semantic lexicon. PMID:23623175

  19. Semantic processes leading to true and false memory formation in schizophrenia.

    PubMed

    Paz-Alonso, Pedro M; Ghetti, Simona; Ramsay, Ian; Solomon, Marjorie; Yoon, Jong; Carter, Cameron S; Ragland, J Daniel

    2013-07-01

    Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under "standard" instructions and the other half under explicit "relational processing" instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit "relational processing" instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon.

  20. Priming children's and adults' analogical problem solutions with true and false memories.

    PubMed

    Howe, Mark L; Threadgold, Emma; Norbury, Jenna; Garner, Sarah; Ball, Linden J

    2013-09-01

    We investigated priming of analogical problem solutions with true and false memories. Children and adults were asked to solve nine verbal proportional analogies, three of which had been primed by Deese-Roediger-McDermott (DRM) lists where the critical lure (and problem solution) was presented as the initial word in the list (true memory priming), three of which were primed by DRM lists whose critical lures were the solution to the verbal proportional analogies (false memory priming), and three of which were unprimed. We controlled for age differences in solution rates (knowledge base) in order to examine developmental differences in speed of processing. As anticipated, the results showed that adults completed the problems significantly faster than children. Furthermore, both children and adults solved problems primed with false memories significantly faster than either those primed with true memories or unprimed problems. For both age groups, there was no significant difference between solution times for unprimed and true primed problems. These findings demonstrate that (a) priming of problem solutions extends to verbal proportional analogies, (b) false memories are more effective at priming problem solutions than true memories, and (c) there are clear positive consequences to the production of false memories.

  1. True-time-delay photonic beamformer for an L-band phased array radar

    NASA Astrophysics Data System (ADS)

    Zmuda, Henry; Toughlian, Edward N.; Payson, Paul M.; Malowicki, John E.

    1995-10-01

    The problem of obtaining a true-time-delay photonic beamformer has recently been a topic of great interest. Many interesting and novel approaches to this problem have been studied. This paper examines the design, construction, and testing of a dynamic optical processor for the control of a 20-element phased array antenna operating at L-band (1.2-1.4 GHz). The approach taken here has several distinct advantages. The actual optical control is accomplished with a class of spatial light modulator known as a segmented mirror device (SMD). This allows for the possibility of controlling an extremely large number (tens of thousands) of antenna elements using integrated circuit technology. The SMD technology is driven by the HDTV and laser printer markets so ultimate cost reduction as well as technological improvements are expected. Optical splitting is efficiently accomplished using a diffractive optical element. This again has the potential for use in antenna array systems with a large number of radiating elements. The actual time delay is achieved using a single acousto-optic device for all the array elements. Acousto-optic device technologies offer sufficient delay as needed for a time steered array. The topological configuration is an optical heterodyne system, hence high, potentially millimeter wave center frequencies are possible by mixing two lasers of slightly differing frequencies. Finally, the entire system is spatially integrated into a 3D glass substrate. The integrated system provides the ruggedness needed in most applications and essentially eliminates the drift problems associated with free space optical systems. Though the system is presently being configured as a beamformer, it has the ability to operate as a general photonic signal processing element in an adaptive (reconfigurable) transversal frequency filter configuration. Such systems are widely applicable in jammer/noise canceling systems, broadband ISDN, and for spread spectrum secure communications

  2. Bias and variance reduction in estimating the proportion of true-null hypotheses

    PubMed Central

    Cheng, Yebin; Gao, Dexiang; Tong, Tiejun

    2015-01-01

    When testing a large number of hypotheses, estimating the proportion of true nulls, denoted by \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\pi _0$\\end{document}, becomes increasingly important. This quantity has many applications in practice. For instance, a reliable estimate of \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\pi _0$\\end{document} can eliminate the conservative bias of the Benjamini–Hochberg procedure on controlling the false discovery rate. It is known that most methods in the literature for estimating \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\pi _0$\\end{document} are conservative. Recently, some attempts have been paid to reduce such estimation bias. Nevertheless, they are either over bias corrected or suffering from an unacceptably large estimation variance. In this paper, we propose a new method for estimating \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$\\pi _0$\\end{document} that aims to reduce the bias and variance of the estimation simultaneously. To achieve this, we first utilize the probability density functions of false-null \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage

  3. The Mechanics of Human Achievement.

    PubMed

    Duckworth, Angela L; Eichstaedt, Johannes C; Ungar, Lyle H

    2015-07-01

    Countless studies have addressed why some individuals achieve more than others. Nevertheless, the psychology of achievement lacks a unifying conceptual framework for synthesizing these empirical insights. We propose organizing achievement-related traits by two possible mechanisms of action: Traits that determine the rate at which an individual learns a skill are talent variables and can be distinguished conceptually from traits that determine the effort an individual puts forth. This approach takes inspiration from Newtonian mechanics: achievement is akin to distance traveled, effort to time, skill to speed, and talent to acceleration. A novel prediction from this model is that individual differences in effort (but not talent) influence achievement (but not skill) more substantially over longer (rather than shorter) time intervals. Conceptualizing skill as the multiplicative product of talent and effort, and achievement as the multiplicative product of skill and effort, advances similar, but less formal, propositions by several important earlier thinkers.

  4. The Mechanics of Human Achievement

    PubMed Central

    Duckworth, Angela L.; Eichstaedt, Johannes C.; Ungar, Lyle H.

    2015-01-01

    Countless studies have addressed why some individuals achieve more than others. Nevertheless, the psychology of achievement lacks a unifying conceptual framework for synthesizing these empirical insights. We propose organizing achievement-related traits by two possible mechanisms of action: Traits that determine the rate at which an individual learns a skill are talent variables and can be distinguished conceptually from traits that determine the effort an individual puts forth. This approach takes inspiration from Newtonian mechanics: achievement is akin to distance traveled, effort to time, skill to speed, and talent to acceleration. A novel prediction from this model is that individual differences in effort (but not talent) influence achievement (but not skill) more substantially over longer (rather than shorter) time intervals. Conceptualizing skill as the multiplicative product of talent and effort, and achievement as the multiplicative product of skill and effort, advances similar, but less formal, propositions by several important earlier thinkers. PMID:26236393

  5. The Effects of Repetition on Children’s True and False Reports

    PubMed Central

    Evans, Angela D.; Brunet, Megan K.; Talwar, Victoria; Bala, Nicholas; Lindsay, Rod C.L.; Lee, Kang

    2013-01-01

    As children are often called upon to provide testimony in court proceedings, determining the veracity of their statements is an important issue. In the course of investigation by police and social workers, children are often repeatedly interviewed about their experiences, though the impact of this repetition on children’s true and false statements remains largely unexamined. The current study analysed semantic differences in children’s truthful and fabricated statements about an event they had or had not participated in. Results revealed that children’s truthful and fabricated reports differed in linguistic content, and that their language also varied with repetition. Discriminant analyses revealed that with repetition, children’s true and false reports became increasingly difficult to differentiate using linguistic markers, though true reports were consistently classified correctly at higher rates than false reports. The implications of these findings for legal procedures concerning child witnesses are discussed. PMID:24265592

  6. Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region.

    PubMed

    Marcotullio, Dario; de Vincentiis, Marco; Iannella, Giannicola; Cerbelli, Bruna; Magliulo, Giuseppe

    2015-01-01

    Introduction. True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma "de novo." We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma. Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma. Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported.

  7. Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region

    PubMed Central

    Marcotullio, Dario; de Vincentiis, Marco; Iannella, Giannicola; Cerbelli, Bruna; Magliulo, Giuseppe

    2015-01-01

    Introduction. True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma “de novo.” We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma. Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma. Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported. PMID:26600963

  8. How Fuzzy-Trace Theory Predicts True and False Memories for Words, Sentences, and Narratives.

    PubMed

    Reyna, Valerie F; Corbin, Jonathan C; Weldon, Rebecca B; Brainerd, Charles J

    2016-03-01

    Fuzzy-trace theory posits independent verbatim and gist memory processes, a distinction that has implications for such applied topics as eyewitness testimony. This distinction between precise, literal verbatim memory and meaning-based, intuitive gist accounts for memory paradoxes including dissociations between true and false memory, false memories outlasting true memories, and developmental increases in false memory. We provide an overview of fuzzy-trace theory, and, using mathematical modeling, also present results demonstrating verbatim and gist memory in true and false recognition of narrative sentences and inferences. Results supported fuzzy-trace theory's dual-process view of memory: verbatim memory was relied on to reject meaning-consistent, but unpresented, sentences (via recollection rejection). However, verbatim memory was often not retrieved, and gist memory supported acceptance of these sentences (via similarity judgment and phantom recollection). Thus, mathematical models of words can be extended to explain memory for complex stimuli, such as narratives, the kind of memory interrogated in law.

  9. A suspended anemometer system for measuring true airspeed on low-speed airplanes

    NASA Technical Reports Server (NTRS)

    Kershner, D. D.

    1977-01-01

    A suspended anemometer system for calibrating pitot-static systems on low speed research airplanes is described. The anemometer measures true airspeed when suspended beneath the airplane on a long cable in regions of undisturbed air. The electrical output of the propeller driven tachometer is a sine wave, the frequency of which is proportional to true airspeed. The anemometer measures true airspeed over a range from 20 to 60 m/sec at altitudes to 3000 m, with an accuracy of + or - 0.5 percent of full scale range. This accuracy is exclusive of errors in the recording system. The stability of the suspended system was investigated and was found adequate in the airspeed range. For the purpose of determining the location of the anemometer relative to the airplane, a method is given for calculating the shape assumed by the deployed cable.

  10. Isolated true surface wave in a radiative band on a surface of a stressed auxetic.

    PubMed

    Trzupek, D; Zieliński, P

    2009-08-14

    We demonstrate that a surface resonance (pseudosurface wave) may transform into a true surface wave, i.e., acquire an infinite lifetime, at a single isolated point within a bulk band (radiative region) in a model of a stressed auxetic material. In contrast with the secluded supersonic elastic surface waves, the one found here does not belong to a dispersion line of true surface waves. Therefore we propose to call it an isolated true surface wave (ITSW). The ITSW manifests itself by a deltalike peak in the local density of states and by anomalies in reflection coefficients. The phenomenon may be useful in redirecting energy and/or information from the bulk to the surface in devices supporting guided acoustic waves.

  11. Determining the True Cost to Deliver Total Hip and Knee Arthroplasty Over the Full Cycle of Care: Preparing for Bundling and Reference-Based Pricing.

    PubMed

    DiGioia, Anthony M; Greenhouse, Pamela K; Giarrusso, Michelle L; Kress, Justina M

    2016-01-01

    The Affordable Care Act accelerates health care providers' need to prepare for new care delivery platforms and payment models such as bundling and reference-based pricing (RBP). Thriving in this environment will be difficult without knowing the true cost of care delivery at the level of the clinical condition over the full cycle of care. We describe a project in which we identified true costs for both total hip and total knee arthroplasty. With the same tool, we identified cost drivers in each segment of care delivery and collected patient experience information. Combining cost and experience information with outcomes data we already collect allows us to drive costs down while protecting outcomes and experiences, and compete successfully in bundling and RBP programs.

  12. False memory for context and true memory for context similarly activate the parahippocampal cortex.

    PubMed

    Karanian, Jessica M; Slotnick, Scott D

    2017-02-24

    The role of the parahippocampal cortex is currently a topic of debate. One view posits that the parahippocampal cortex specifically processes spatial layouts and sensory details (i.e., the visual-spatial processing view). In contrast, the other view posits that the parahippocampal cortex more generally processes spatial and non-spatial contexts (i.e., the general contextual processing view). A large number of studies have found that true memories activate the parahippocampal cortex to a greater degree than false memories, which would appear to support the visual-spatial processing view as true memories are typically associated with greater visual-spatial detail than false memories. However, in previous studies, contextual details were also greater for true memories than false memories. Thus, such differential activity in the parahippocampal cortex may have reflected differences in contextual processing, which would challenge the visual-spatial processing view. In the present functional magnetic resonance imaging (fMRI) study, we employed a source memory paradigm to investigate the functional role of the parahippocampal cortex during true memory and false memory for contextual information to distinguish between the visual-spatial processing view and the general contextual processing view. During encoding, abstract shapes were presented to the left or right of fixation. During retrieval, old shapes were presented at fixation and participants indicated whether each shape was previously on the "left" or "right" followed by an "unsure", "sure", or "very sure" confidence rating. The conjunction of confident true memories for context and confident false memories for context produced activity in the parahippocampal cortex, which indicates that this region is associated with contextual processing. Furthermore, the direct contrast of true memory and false memory produced activity in the visual cortex but did not produce activity in the parahippocampal cortex. The present

  13. True status of smear-positive pulmonary tuberculosis defaulters in Malawi.

    PubMed Central

    Kruyt, M. L.; Kruyt, N. D.; Boeree, M. J.; Harries, A. D.; Salaniponi, F. M.; van Noord, P. A.

    1999-01-01

    The article reports the results of a study to determine the true outcome of 8 months of treatment received by smear-positive pulmonary tuberculosis (PTB) patients who had been registered as defaulters in the Queen Elizabeth Central Hospital (QECH) and Mlambe Mission Hospital (MMH), Blantyre, Malawi. The treatment outcomes were documented from the tuberculosis registers of all patients registered between 1 October 1994 and 30 September 1995. The true treatment outcome for patients who had been registered as defaulters was determined by making personal inquiries at the treatment units and the residences of patients or relatives and, in a few cases, by writing to the appropriate postal address. Interviews were carried out with patients who had defaulted and were still alive and with matched, fully compliant PTB patients who had successfully completed the treatment to determine the factors associated with defaulter status. Of the 1099 patients, 126 (11.5%) had been registered as defaulters, and the true treatment outcome was determined for 101 (80%) of the latter; only 22 were true defaulters, 31 had completed the treatment, 31 had died during the treatment period, and 17 had left the area. A total of 8 of the 22 true defaulters were still alive and were compared with the compliant patients. Two significant characteristics were associated with the defaulters; they were unmarried; and they did not know the correct duration of antituberculosis treatment. Many of the smear-positive tuberculosis patients who had been registered as defaulters in the Blantyre district were found to have different treatment outcomes, without defaulting. The quality of reporting in the health facilities must therefore be improved in order to exclude individuals who are not true defaulters. PMID:10361755

  14. Comparison of measured Varian Clinac 21EX and TrueBeam accelerator electron field characteristics.

    PubMed

    Lloyd, Samantha A M; Zavgorodni, Sergei; Gagne, Isabelle M

    2015-07-08

    Dosimetric comparisons of radiation fields produced by Varian's newest linear accelerator, the TrueBeam, with those produced by older Varian accelerators are of interest from both practical and research standpoints. While photon fields have been compared in the literature, similar comparisons of electron fields have not yet been reported. In this work, electron fields produced by the TrueBeam are compared with those produced by Varian's Clinac 21EX accelerator. Diode measurements were taken of fields shaped with electron applicators and delivered at 100 cm SSD, as well as those shaped with photon MLCs without applicators and delivered at 70 cm SSD for field sizes ranging from 5 × 5 to 25 × 25 cm² at energies between 6 and 20 MeV. Additionally, EBT2 and EBT3 radio-chromic film measurements were taken of an MLC-shaped aperture with closed leaf pairs delivered at 70 cm SSD using 6 and 20 MeV electrons. The 6 MeV fields produced by the TrueBeam and Clinac 21EX were found to be almost indistinguishable. At higher energies, TrueBeam fields shaped by electron applicators were generally flatter and had less photon contamination compared to the Clinac 21EX. Differences in PDDs and profiles fell within 3% and 3 mm for the majority of measurements. The most notable differences for open fields occurred in the profile shoulders for the largest applicator field sizes. In these cases, the TrueBeam and Clinac 21EX data differed by as much as 8%. Our data indicate that an accurate electron beam model of the Clinac 21EX could be used as a starting point to simulate electron fields that are dosimetrically equivalent to those produced by the TrueBeam. Given that the Clinac 21EX shares head geometry with Varian's iX, Trilogy, and Novalis TX accelerators, our findings should also be applicable to these machines.

  15. Effects of Part-Time Work on School Achievement During High School

    ERIC Educational Resources Information Center

    Singh, Kusum; Chang, Mido; Dika, Sandra

    2007-01-01

    The authors explored the effects of part-time work on school achievement during high school. To estimate the true effects of part-time work on school grades, the authors included family background, students' educational aspirations, and school engagement as controls. Although a substantial literature exists on the relationship of part-time work…

  16. Quantifying the Consequences of Missing School: Linking School Nurses to Student Absences to Standardized Achievement

    ERIC Educational Resources Information Center

    Gottfried, Michael A.

    2013-01-01

    Background/Context: Parents, policymakers, and researchers uphold that missing school has negative implications on schooling success, particularly for students in urban schools. However, it has thus far been an empirical challenge within educational research to estimate the true effect that absences have on achievement outcomes. This study…

  17. A Correlational Study of Building Principal Emotional Intelligence and the Connection to Academic Achievement

    ERIC Educational Resources Information Center

    Fish, James

    2012-01-01

    While student achievement is only one indicator of a building principal's effectiveness, it is widely considered to be one of the most important. This is especially true in regard to the current climate of accountability surrounding education. Multiple studies have yielded results concerning the behaviors and characteristics of building…

  18. The Development of Product Parity Sensitivity in Children with Mathematics Learning Disability and in Typical Achievers

    ERIC Educational Resources Information Center

    Rotem, Avital; Henik, Avishai

    2013-01-01

    Parity helps us determine whether an arithmetic equation is true or false. The current research examines the development of sensitivity to parity cues in multiplication in typically achieving (TA) children (grades 2, 3, 4 and 6) and in children with mathematics learning disabilities (MLD, grades 6 and 8), via a verification task. In TA children…

  19. Seeds of a Soldier: The True Story of Edgar Allan Poe - The Sergeant Major

    DTIC Science & Technology

    2003-01-01

    2003 2. REPORT TYPE 3. DATES COVERED 00-00-2003 to 00-00-2003 4. TITLE AND SUBTITLE Seeds of a Soldier. The true story of Edgar Allan Poe - the...Std Z39-18 Army Space Journal Fall 200360 By Michael L. Howard Seeds of a Soldier The true story of Edgar Allan Poe — the Sergeant Major...the Managing Editor via email to richard.burks@arspace.army.mil dgar Allan Poe wore U.S. Army sergeant major stripes. Using the name Edgar A. Perry

  20. The effectiveness of family planning programs evaluated with true experimental designs.

    PubMed Central

    Bauman, K E

    1997-01-01

    OBJECTIVES: This paper describes the magnitude of effects for family planning programs evaluated with true experimental designs. METHODS: Studies that used true experimental designs to evaluate family planning programs were identified and their results subjected to meta-analysis. RESULTS: For the 14 studies with the information needed to calculate effect size, the Pearson r between program and effect variables ranged from -.08 to .09 and averaged .08. CONCLUSIONS: The programs evaluated in the studies considered have had, on average, smaller effects than many would assume and desire. PMID:9146451

  1. True congenital dislocation of shoulder: A case report and review of the literature

    PubMed Central

    Sudesh, Pebam; Rangdal, Sushil; Bali, Kamal; Kumar, Vishal; Gahlot, Nitesh; Patel, Sandeep

    2010-01-01

    The dislocation of a shoulder joint in infancy is extremely rare and is usually the result of traumatic birth injuries, a sequel to brachial plexus injury, or a true congenital dislocation of shoulder. With more advanced obstetric care, the incidence of first two types has drastically decreased. We report a case of true congenital dislocation of shoulder, second of its kind, in a child who was delivered by cesarean section thereby negating any influence of trauma. We report the case because of its rarity, and review the available literature on this topic. We also discuss the management options when encountered with such a rare case scenario. PMID:21655006

  2. Achieving reuse of computable guideline systems.

    PubMed

    Johnson, P; Tu, S; Jones, N

    2001-01-01

    We describe an architecture for reusing computable guidelines and the programs used to interpret them across varied legacy clinical systems. Developed for the PRODIGY 3 project, our architecture aims to support interactive, point of care use of guidelines in primary care. Legacy medical record systems in UK primary care are diverse, using different terminologies, different data models, and varying user-interface philosophies. However, our goal is to provide common guideline knowledge bases and system components, while achieving full integration with the host medical record system, and a user interface tailored to that system. In conjunction with system suppliers, we identified areas of standardization required to achieve this goal. Firstly, standardized interfaces were created for mediation with the legacy system medical record and for act management. Secondly, a standard interface was developed for communication with the User Interface for guideline interaction. Thirdly, a terminology mapping knowledge base and system component was provided. Lastly, we developed a numeric unit conversion knowledge base and system component. The standardization of this architecture was achieved by close collaboration with existing vendors of Primary Care computing systems in the UK. The work has been verified by two suppliers successfully building and deploying systems with User Interfaces which mirror their normal look and feel, communicating fully with existing medical records, while using identical Guideline Interpreter components and knowledge bases. Encouragingly further experiments in other areas of clinical decision support have not required extension of our interfaces.

  3. The evaluation and comparison of kidney length obtained from axial cuts in spiral CT scan with its true length

    PubMed Central

    Karami, Mehdi; Rahimi, Farshad; Tajadini, Mohammadhasan

    2015-01-01

    Background: Increased size of kidney is the main symptom of pyelonephritis and renal ischemia in children. Ultrasound and computed tomography (CT) scan methods are the imaging methods for evaluating the urogenital system. The aim of this study is to compare the kidney length obtained from spiral CT scan with the true length obtained from multi-slice CT. Materials and Methods: From 100 patients 200 kidneys were examined in Alzahra Hospital in 2012. Multi-slice CT was used to obtain coronal and sagittal cuts to find the length of kidneys. Results: The mean values of true size of axial sections of the right and left kidneys were 108.37 ± 12.3 mm and 109.74 ± 13.6 mm, respectively. The mean difference of axial sections’ lengths in the right and left kidneys was 1.37 ± 1.22 mm. The mean values of length in the spiral CT scan of the right and left kidneys were 98.61 ± 15.8 mm and 103.11 ± 15.9 mm, respectively. The difference in the estimated size by multi-slice CT scan in oblique and axial images was significant (9.77 ± 1.19 mm and 6.63 ± 0.8 mm for the right and left kidneys, respectively (P < 0.001). Conclusion: The average size of both kidneys determined in axial images was smaller than the actual size. The estimation of kidney size in axial images is not reliable, and to obtain the actual size, it is required to have the coronal and sagittal cuts with proper quality, which could be achieved by multi-slice method. PMID:25709984

  4. EDUCATIONAL ACHIEVEMENT AND THE NAVAJO.

    ERIC Educational Resources Information Center

    HAAS, JOHN; MELVILLE, ROBERT

    A STUDY WAS DEVISED TO APPRAISE THE ACADEMIC ACHIEVEMENT OF NAVAJO STUDENTS LIVING IN DORMITORIES AWAY FROM THE INDIAN RESERVATION. THE FOLLOWING SEVEN FACTORS WERE CHOSEN TO BE INVESTIGATED AS BEING DIRECTLY RELATED TO ACHIEVEMENT--(1) INTELLIGENCE, (2) READING ABILITY, (3) ANXIETY, (4) SELF-CONCEPT, (5) MOTIVATION, (6) VERBAL DEVELOPMENT, (7)…

  5. Sociocultural Origins of Achievement Motivation

    ERIC Educational Resources Information Center

    Maehr, Martin L.

    1977-01-01

    Presents a theoretical review of work on sociocultural influences on achievement, focusing on a critical evaluation of the work of David McClellan. Offers an alternative conception of achievement motivation which stresses the role of contextual and situational factors in addition to personality factors. Available from: Transaction Periodicals…

  6. Raising Boys' Achievement in Schools.

    ERIC Educational Resources Information Center

    Bleach, Kevan, Ed.

    This book offers insights into the range of strategies and good practice being used to raise the achievement of boys. Case studies by school-based practitioners suggest ideas and measures to address the issue of achievement by boys. The contributions are: (1) "Why the Likely Lads Lag Behind" (Kevan Bleach); (2) "Helping Boys Do…

  7. Teaching the Low Level Achiever.

    ERIC Educational Resources Information Center

    Salomone, Ronald E., Ed.

    1986-01-01

    Intended for teachers of the English language arts, the articles in this issue offer suggestions and techniques for teaching the low level achiever. Titles and authors of the articles are as follows: (1) "A Point to Ponder" (Rachel Martin); (2) "Tracking: A Self-Fulfilling Prophecy of Failure for the Low Level Achiever" (James Christopher Davis);…

  8. Early Intervention and Student Achievement

    ERIC Educational Resources Information Center

    Hormes, Mridula T.

    2009-01-01

    The United States Department of Education has been rigorous in holding all states accountable with regard to student achievement. The No Child Left Behind Act of 2001 clearly laid out federal mandates for all schools to follow. K-12 leaders of public schools are very aware of the fact that results in terms of student achievement need to improve…

  9. Parental Involvement and Academic Achievement

    ERIC Educational Resources Information Center

    Goodwin, Sarah Christine

    2015-01-01

    This research study examined the correlation between student achievement and parent's perceptions of their involvement in their child's schooling. Parent participants completed the Parent Involvement Project Parent Questionnaire. Results slightly indicated parents of students with higher level of achievement perceived less demand or invitations…

  10. Asperger Syndrome and Academic Achievement.

    ERIC Educational Resources Information Center

    Griswold, Deborah E.; Barnhill, Gena P.; Myles, Brenda Smith; Hagiwara, Taku; Simpson, Richard L.

    2002-01-01

    A study focused on identifying the academic characteristics of 21 children and youth who have Asperger syndrome. Students had an extraordinary range of academic achievement scores, extending from significantly above average to far below grade level. Lowest achievement scores were shown for numerical operations, listening comprehension, and written…

  11. Perils of Standardized Achievement Testing

    ERIC Educational Resources Information Center

    Haladyna, Thomas M.

    2006-01-01

    This article argues that the validity of standardized achievement test-score interpretation and use is problematic; consequently, confidence and trust in such test scores may often be unwarranted. The problem is particularly severe in high-stakes situations. This essay provides a context for understanding standardized achievement testing, then…

  12. Stress Correlates and Academic Achievement.

    ERIC Educational Resources Information Center

    Bentley, Donna Anderson; And Others

    An ongoing concern for educators is the identification of factors that contribute to or are associated with academic achievement; one such group of variables that has received little attention are those involving stress. The relationship between perceived sources of stress and academic achievement was examined to determine if reactions to stress…

  13. School Size and Student Achievement

    ERIC Educational Resources Information Center

    Riggen, Vicki

    2013-01-01

    This study examined whether a relationship between high school size and student achievement exists in Illinois public high schools in reading and math, as measured by the Prairie State Achievement Exam (PSAE), which is administered to all Illinois 11th-grade students. This study also examined whether the factors of socioeconomic status, English…

  14. Immunopharmacology 2011: an updated report of clinical achievements and perspectives.

    PubMed

    Landys Chovel, Mario; Perea, Silvio; de los Ángeles Robinson, María; Rodeiro, Idania; Delgado, René; Ochoa, Rolando F; Hernández, Ana María

    2011-11-01

    On 26-30 June 2011 the Cuban Society of Pharmacology organized the Second International Congress on Immunopharmacology (Immunopharmacology 2011), held at the beautiful Convention Centre 'Plaza América' and the Meliá Varadero Hotel, in Varadero beach, Cuba. The main topics of the congress were immunopharmacology (including inflammation, cancer immunotherapy and immunomodulation), neuroimmunology, and the pharmacology of cytochrome P450 and transporters, among other relevant and updated related topics. Immunopharmacology 2011 offered an outstanding scientific program with the active contribution of 90 speakers from 23 foreign countries, as well as more than 170 Cuban researchers from the most important local institutions devoted to the development of immunology and pharmacology sciences.

  15. Robust Scale Transformation Methods in IRT True Score Equating under Common-Item Nonequivalent Groups Design

    ERIC Educational Resources Information Center

    He, Yong

    2013-01-01

    Common test items play an important role in equating multiple test forms under the common-item nonequivalent groups design. Inconsistent item parameter estimates among common items can lead to large bias in equated scores for IRT true score equating. Current methods extensively focus on detection and elimination of outlying common items, which…

  16. No Evidence for True Training and Transfer Effects after Inhibitory Control Training in Young Healthy Adults

    ERIC Educational Resources Information Center

    Enge, Sören; Behnke, Alexander; Fleischhauer, Monika; Küttler, Lena; Kliegel, Matthias; Strobel, Alexander

    2014-01-01

    Recent studies reported that training of working memory may improve performance in the trained function and beyond. Other executive functions, however, have been rarely or not yet systematically examined. The aim of this study was to test the effectiveness of inhibitory control (IC) training to produce true training-related function improvements…

  17. Right and Righteous: Children's Incipient Understanding and Evaluation of True and False Statements

    ERIC Educational Resources Information Center

    Lyon, Thomas D.; Quas, Jodi A.; Carrick, Nathalie

    2013-01-01

    Two studies examined young children's early understanding and evaluation of truth telling and lying and the role that factuality plays in their judgments. Study 1 (one hundred four 2- to 5-year-olds) found that even the youngest children reliably accepted true statements and rejected false statements and that older children's ability to…

  18. Latent variable modeling of cognitive processes in true and false recognition of words: A developmental perspective.

    PubMed

    Bouwmeester, Samantha; Verkoeijen, Peter P J L

    2010-05-01

    The present study aimed at testing theoretical predictions of the fuzzy-trace theory about true and false recognition. The effects of semantic relatedness and study opportunity on true and false recognition of words from Deese, Roediger, McDermott lists (J. Deese, 1959; D. R. Read, 1996; H. L. Roediger & K. B. McDermott, 1995) were evaluated in 7- to 12-year-old children (N = 151). Instead of a traditional analysis of variance, the authors used a relatively novel statistical analysis technique, latent class factor analysis, to test the hypotheses pertaining to the effect of semantic relatedness and study opportunity on children's true and false recognition given their low or high verbatim-trace and gist-trace level. The results showed that variation in true recognition of target words from semantically related and unrelated word lists that were either studied once or repeated could be explained well by variation in verbatim-trace and gist-trace level. Variation in false recognition of semantically related distractors also could be explained by variation in gist-trace level, but the recollection-rejection hypothesis was not confirmed. The variable age was positively but weakly related to gist-trace level, but no significant relationship was found between age and verbatim-trace level.

  19. Phylogenetics and evolutionary morphology of the Neotropical true bug genus Epipolops (Hemiptera: Heteroptera: Geocoridae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Species of Epipolops Herrich-Schaeffer (Hemiptera: Geocoridae), comprising the largest genus of Pamphantinae, are among the most bizarre true bugs because of their striking morphology. To elucidate evolutionary morphology in Epipolops, a phylogenetic analysis was performed using 17 species and 36 ad...

  20. Multigene molecular phylogenetics reveals true morels (Morchella) are especially species-rich in China

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The phylogenetic diversity of true morels (Morchella) in China was estimated by initially analyzing nuclear ribosomal internal transcribed spacer (ITS) rDNA sequences from 361 specimens collected in 21 provinces during the 2003-2011 growing seasons, together with six collections obtained on loan fro...

  1. Kothmale Community Radio Interorg Project: True Community Radio or Feel-Good Propaganda?

    ERIC Educational Resources Information Center

    Harvey-Carter, Liz

    2009-01-01

    The Kothmale Community Radio and Interorg project in Sri Lanka has been hailed as an example of how a community radio initiative should function in a developing nation. However, there is some question about whether the Kothmale Community Interorg Project is a true community radio initiative that empowers local communities to access ICT services…

  2. Nebulized Fentanyl for Dyspnea in a Hospice Patient with True Allergy to Morphine and Hydromorphone.

    PubMed

    Wahler, Robert G; Smith, David B; Mulcahy, Kimberly B

    2017-03-01

    An 86-year-old white female was admitted to hospice care with lung cancer. Even with optimal medical management, she suffered from dyspnea and required opioid therapy. However, the patient had a true morphine and hydromorphone allergy. She was administered nebulized fentanyl for symptomatic relief of dyspnea with good effect and she did not experience any allergic response.

  3. True Chemotaxis in Oxygen Gradients of the Sulfur-Oxidizing Bacterium Thiovulum majus

    PubMed Central

    Thar, Roland; Fenchel, Tom

    2001-01-01

    Observations of free-swimming Thiovulum majus cells show that these bacteria exhibit a phobic response as well as true chemotaxis in oxygen gradients. Both phenomena of their chemotactic behavior are integrated into a single model of helical klinotaxis, which is demonstrated by computer simulations. PMID:11425757

  4. Nurses Behave Differentially to Neonates in Terms of Their True Gender Compared to Their Ascribed Gender.

    ERIC Educational Resources Information Center

    Hollenbeck, Albert R.; And Others

    Response patterns of 24 female nurses to 2-day-old neonates who had been arbitrarily labeled male or female were studied. A total of 17 reliable behaviors of nurses were scored from videotapes of nurse-infant interaction. Nurses responded differentially to neonates based on true gender rather than ascribed gender. Nurses held boys more by their…

  5. Fiedler's Least Preferred Coworker (LPC) Instrument: An Investigation of Its True Bipolarity.

    ERIC Educational Resources Information Center

    Schriesheim, Chester A.; Klich, Nancy R.

    1991-01-01

    Two studies were conducted, using 131 business administration majors (53 males and 78 females), to examine the psychological midpoints of the 18 bipolar adjective pairs of Fiedler's Least Preferred Coworker (LPC) instrument. Six of the LPC adjective pairs were found to deviate significantly from true bipolarity. (SLD)

  6. [Primary-care morbidity and true morbidity due to acute respiratory infections].

    PubMed

    Pérez Rodríguez, A E; González Ochoa, E; Bravo González, J R; Carlos Silva, L; Linton, T

    1992-01-01

    The present work presents the study of morbidity due to acute respiratory infections (ARI) in areas of the town of Lisa in Ciudad Habana, and Isla Juventud (Cuba), to characterize different aspects of morbidity measured by health care attendance and to measure true morbidity. About 90% of consultations for ARI were first-time consultations, while their ratio to further consultations was 5.3. True morbidity rates (TMR), obtained trough active research, ranged from 110.4 to 163.4 cases per 1000 inhabitants, considerably higher than morbidity rates measured by primary care consultations (MRPCC) in the same time period. The true morbidity index (TMI), as measured by the ratio of the two previous rates, ranged from 5 to 15. A high proportion (47.6%) of cases reported no medical care attendance. These results provide approximate estimates of true morbidity in the study area, and allow the establishment of a new control program, also improving epidemiologic surveillance within primary care activities.

  7. Simulation of a true-triaxial deformation test on anisotropic gneiss using FLAC3D

    NASA Astrophysics Data System (ADS)

    Ye, Shenghua; Sehizadeh, Mehdi; Nasseri, Mohammad; Young, Paul

    2016-04-01

    A series of true-triaxial experiments have been carried out at the University of Toronto's Rock Fracture Dynamics Laboratory. Isotropic pegmatite and gneiss have been used to systematically study the effect of anisotropy on the strength, behaviour and seismic response. Samples were loaded under true-triaxial stress conditions and subjected to complex loading and unloading histories associated with rock deformation around underground openings. The results show expected patterns of weakness from preferentially oriented samples and highlight the importance of unloading history under true-triaxial conditions on the deformation and seismic response of the samples. These tests have been used to validate a synthetic simulation using the Itasca FLAC3D numerical code. The paper describes the FLAC3D simulations of the complex true-triaxial loading and unloading history of the different anisotropic samples. Various parameters were created to describe the physico-mechanical properties of the synthetic rock samples. Foliation planes of preferential orientations with respect to the primary loading direction were added to the synthetic rock samples to reflect the anisotropy of the gneiss. These synthetic rock samples were subjected to the same loading and unloading paths as the real rock samples, and failed in the same mechanism as what was observed from the experiments, and thus it proved the validity of this numerical simulation with FLAC3D.

  8. Confidence Intervals for True Scores Using the Skew-Normal Distribution

    ERIC Educational Resources Information Center

    Garcia-Perez, Miguel A.

    2010-01-01

    A recent comparative analysis of alternative interval estimation approaches and procedures has shown that confidence intervals (CIs) for true raw scores determined with the Score method--which uses the normal approximation to the binomial distribution--have actual coverage probabilities that are closest to their nominal level. It has also recently…

  9. The Development of Automatic and Controlled Inhibitory Retrieval Processes in True and False Recall

    ERIC Educational Resources Information Center

    Knott, Lauren M.; Howe, Mark L.; Wimmer, Marina C.; Dewhurst, Stephen A.

    2011-01-01

    In three experiments, we investigated the role of automatic and controlled inhibitory retrieval processes in true and false memory development in children and adults. Experiment 1 incorporated a directed forgetting task to examine controlled retrieval inhibition. Experiments 2 and 3 used a part-set cue and retrieval practice task to examine…

  10. Can Maltreated Children Inhibit True and False Memories for Emotional Information?

    ERIC Educational Resources Information Center

    Howe, Mark L.; Toth, Sheree L.; Cicchetti, Dante

    2011-01-01

    The authors examined 284 maltreated and nonmaltreated children's (6- to 12-year-olds) ability to inhibit true and false memories for neutral and emotional information using the Deese/Roediger-McDermott (DRM) paradigm. Children studied either emotional or neutral DRM lists in a control condition or were given directed-remembering or…

  11. Searching for the true diet of marine predators: incorporating Bayesian priors into stable isotope mixing models.

    PubMed

    Chiaradia, André; Forero, Manuela G; McInnes, Julie C; Ramírez, Francisco

    2014-01-01

    Reconstructing the diet of top marine predators is of great significance in several key areas of applied ecology, requiring accurate estimation of their true diet. However, from conventional stomach content analysis to recent stable isotope and DNA analyses, no one method is bias or error free. Here, we evaluated the accuracy of recent methods to estimate the actual proportion of a controlled diet fed to a top-predator seabird, the Little penguin (Eudyptula minor). We combined published DNA data of penguins scats with blood plasma δ(15)N and δ(13)C values to reconstruct the diet of individual penguins fed experimentally. Mismatch between controlled (true) ingested diet and dietary estimates obtained through the separately use of stable isotope and DNA data suggested some degree of differences in prey assimilation (stable isotope) and digestion rates (DNA analysis). In contrast, combined posterior isotope mixing model with DNA Bayesian priors provided the closest match to the true diet. We provided the first evidence suggesting that the combined use of these complementary techniques may provide better estimates of the actual diet of top marine predators- a powerful tool in applied ecology in the search for the true consumed diet.

  12. How well do ITS rDNA sequences differentiate species of true morels (Morchella)?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Arguably more mycophiles hunt true morels (Morchella) during their brief fruiting season each spring in the Northern Hemisphere than any other wild edible fungus. Concerns about overharvesting by individual collectors and commercial enterprises make it essential that science-based management practic...

  13. On a Method of Eliciting True/False Judgments from Young Children

    ERIC Educational Resources Information Center

    Lloyd, Peter; Donaldson, Margaret

    1976-01-01

    Experiments in eliciting true/false judgments from young children aged 3-5 used a "talking doll," a toy panda with a speaker installed. The procedure has been used in studies of language comprehension, communication skills, and free conversation experiments. (CHK)

  14. Properties of true quaternary fission of nuclei with allowance for its multistep and sequential character

    NASA Astrophysics Data System (ADS)

    Kadmensky, S. G.; Titova, L. V.; Bulychev, A. O.

    2015-07-01

    An analysis of basicmechanisms of binary and ternary fission of nuclei led to the conclusion that true ternary and quaternary fission of nuclei has a sequential two-step (three-step) character, where, at the first step, a fissile nucleus emits a third light particle (third and fourth light particles) under shakeup effects associated with a nonadiabatic character of its collective deformation motion, whereupon the residual nucleus undergoes fission to two fission fragments. Owing to this, the formulas derived earlier for the widths with respect to sequential two- and three-step decays of nuclei in constructing the theory of two-step twoproton decays and multistep decays in chains of genetically related nuclei could be used to describe the relative yields and angular and energy distributions of third and fourth light particles emitted in ( α, α), ( t, t), and ( α, t) pairs upon the true quaternary spontaneous fission of 252Cf and thermal-neutron-induced fission of 235U and 233U target nuclei. Mechanisms that explain a sharp decrease in the yield of particles appearing second in time and entering into the composition of light-particle pairs that originate from true quaternary fission of nuclei in relation to the yields of analogous particles in true ternary fission of nuclei are proposed.

  15. Generational Theory and the U.S. Army: Harnessing the True Power of Human Capital

    DTIC Science & Technology

    2011-04-01

    Studies Research Paper September 2010- April 2011 4. TITLE AND ·sUBTITLE 5a. CONTRACT NUMBER Generational Theory and the U.S. Army: Harnessing the...MASTER OF MILITARY STUDIES GENERATIONAL THEORY AND THE U.S. ARMY: HARNESSING THE TRUE POWER OF HUMAN CAPITAL SUBMITTED IN PARTIAL FULFILLMENT dF...

  16. Observed Score and True Score Equating Procedures for Multidimensional Item Response Theory

    ERIC Educational Resources Information Center

    Brossman, Bradley Grant

    2010-01-01

    The purpose of this research was to develop observed score and true score equating procedures to be used in conjunction with the Multidimensional Item Response Theory (MIRT) framework. Currently, MIRT scale linking procedures exist to place item parameter estimates and ability estimates on the same scale after separate calibrations are conducted.…

  17. Asymptotic Standard Errors for Item Response Theory True Score Equating of Polytomous Items

    ERIC Educational Resources Information Center

    Cher Wong, Cheow

    2015-01-01

    Building on previous works by Lord and Ogasawara for dichotomous items, this article proposes an approach to derive the asymptotic standard errors of item response theory true score equating involving polytomous items, for equivalent and nonequivalent groups of examinees. This analytical approach could be used in place of empirical methods like…

  18. Standard Error Estimation of 3PL IRT True Score Equating with an MCMC Method

    ERIC Educational Resources Information Center

    Liu, Yuming; Schulz, E. Matthew; Yu, Lei

    2008-01-01

    A Markov chain Monte Carlo (MCMC) method and a bootstrap method were compared in the estimation of standard errors of item response theory (IRT) true score equating. Three test form relationships were examined: parallel, tau-equivalent, and congeneric. Data were simulated based on Reading Comprehension and Vocabulary tests of the Iowa Tests of…

  19. Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses.

    PubMed

    Olstad, K; Østevik, L; Carlson, C S; Ekman, S

    2015-09-01

    Osteochondrosis arises as a result of focal failure of the blood supply to growth cartilage. The current aim was to examine the pathogenesis of pseudocysts and true cysts in subchondral bone following failure of the blood supply to the articular-epiphyseal cartilage complex in horses. Cases were recruited based on identification of lesions (n = 17) that were considered likely to progress to or to represent pseudocysts or true cysts in epiphyseal bone in histological sections and included 10 horses ranging in age from 48 days to 5 years old. Cases comprised 3 warmbloods, 3 Standardbreds, 1 Quarter horse and 1 Arabian with spontaneous lesions and 2 Fjord ponies with experimentally induced lesions. Seven lesions consisted of areas of ischemic chondronecrosis and were compatible with pseudocysts. Two lesions were located at intermediate depth in epiphyseal growth cartilage, 2 lesions were located in the ossification front, 2 lesions were located in epiphyseal bone and 1 lesion was located in the metaphyseal growth plate (physis). Ten lesions contained dilated blood vessels and were compatible with true cysts. In 2 lesions the dilated blood vessels were located within the lumina of failed cartilage canals. In the 8 remaining lesions areas of ischemic chondronecrosis were associated with granulation tissue in the subjacent bone and dilated vessels were located within this granulation tissue. Failure of the blood supply and ischemic chondronecrosis can lead to formation of pseudocysts or dilatation of blood vessels and formation of true cysts in the epiphyseal bone of horses.

  20. Woman's "True" Profession: Voices from the History of Teaching. 2nd Edition

    ERIC Educational Resources Information Center

    Hoffman, Nancy

    2003-01-01

    A rich and fascinating portrait of education life in America between 1830 and 1920, "Woman's 'True' Profession" is an indispensable contribution to our understanding of the teaching profession. "Women have always been teachers." So begins this second edition of Nancy Hoffman's classic history of women and the teaching…

  1. Multiple-Choice and True/False Tests: Myths and Misapprehensions

    ERIC Educational Resources Information Center

    Burton, Richard F.

    2005-01-01

    Examiners seeking guidance on multiple-choice and true/false tests are likely to encounter various faulty or questionable ideas. Twelve of these are discussed in detail, having to do mainly with the effects on test reliability of test length, guessing and scoring method (i.e. number-right scoring or negative marking). Some misunderstandings could…

  2. Acoustically steered and rotated (ASTRO) optoelectronic 2D true-time-delay generation

    NASA Astrophysics Data System (ADS)

    Paek, Eung Gi; Choe, Joon Y.; Oh, Tae Kwan

    1997-12-01

    A new 2-D true time delay (TTD) generation system architecture for phased array antennas is described. The method uses fiber chirp gratings and acousto-optic beam deflectors. By combining free-space optics and guided optics, the device complexity in conventional TTD systems has been significantly reduced. A proof-of-concept experimental results are demonstrated.

  3. Holographic Structuring of Elastomer Actuator: First True Monolithic Tunable Elastomer Optics.

    PubMed

    Ryabchun, Alexander; Kollosche, Matthias; Wegener, Michael; Sakhno, Oksana

    2016-12-01

    Volume diffraction gratings (VDGs) are inscribed selectively by diffusive introduction of benzophenone and subsequent UV-holographic structuring into an electroactive dielectric elastomer actuator (DEA), to afford a continuous voltage-controlled grating shift of 17%. The internal stress coupling of DEA and optical domain allows for a new generation of true monolithic tunable elastomer optics with voltage controlled properties.

  4. Assessing Class-Wide Consistency and Randomness in Responses to True or False Questions Administered Online

    ERIC Educational Resources Information Center

    Pawl, Andrew; Teodorescu, Raluca E.; Peterson, Joseph D.

    2013-01-01

    We have developed simple data-mining algorithms to assess the consistency and the randomness of student responses to problems consisting of multiple true or false statements. In this paper we describe the algorithms and use them to analyze data from introductory physics courses. We investigate statements that emerge as outliers because the class…

  5. A preliminary assessment of the true morels (Morchella) in Newfoundland and Labrador

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A preliminary assessment of true morels (Morchella) from Newfoundland and Labrador (NL) was obtained by using DNA sequence data from portions of three genes to identify 20 collections from Newfoundland and one from a remote location in Labrador. To place this work in a broader context, data on 25 co...

  6. A multigene molecular phylogenetic assessment of true morels (Morchella) in turkey

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A collection of 247 true morels (Morchella spp.) primarily from the Mediterranean and Aegean Regions of Southern Turkey, were analyzed for species diversity using partial RNA polymerase I (RPB1) and nuclear ribosomal large subunit (LSU) rDNA gene sequences. Based on the result of this initial scree...

  7. Multiple Choice Converted to True-False: Comparative Reliabilities and Validities.

    ERIC Educational Resources Information Center

    Green, Kathy

    Forty three-option multiple choice (MC) statements on a midterm examination were converted to 120 true-false (TF) statements, identical in content. Test forms (MC and TF) were randomly administered to 50 undergraduates, to investigate the validity and internal consistency reliability of the two forms. A Kuder-Richardson formula 20 reliability was…

  8. A Maximum NEC Criterion for Compton Collimation to Accurately Identify True Coincidences in PET

    PubMed Central

    Chinn, Garry; Levin, Craig S.

    2013-01-01

    In this work, we propose a new method to increase the accuracy of identifying true coincidence events for positron emission tomography (PET). This approach requires 3-D detectors with the ability to position each photon interaction in multi-interaction photon events. When multiple interactions occur in the detector, the incident direction of the photon can be estimated using the Compton scatter kinematics (Compton Collimation). If the difference between the estimated incident direction of the photon relative to a second, coincident photon lies within a certain angular range around colinearity, the line of response between the two photons is identified as a true coincidence and used for image reconstruction. We present an algorithm for choosing the incident photon direction window threshold that maximizes the noise equivalent counts of the PET system. For simulated data, the direction window removed 56%–67% of random coincidences while retaining > 94% of true coincidences from image reconstruction as well as accurately extracted 70% of true coincidences from multiple coincidences. PMID:21317079

  9. Stochastic Processes as True-Score Models for Highly Speeded Mental Tests.

    ERIC Educational Resources Information Center

    Moore, William E.

    The previous theoretical development of the Poisson process as a strong model for the true-score theory of mental tests is discussed, and additional theoretical properties of the model from the standpoint of individual examinees are developed. The paper introduces the Erlang process as a family of test theory models and shows in the context of…

  10. Properties of true quaternary fission of nuclei with allowance for its multistep and sequential character

    SciTech Connect

    Kadmensky, S. G. Titova, L. V.; Bulychev, A. O.

    2015-07-15

    An analysis of basicmechanisms of binary and ternary fission of nuclei led to the conclusion that true ternary and quaternary fission of nuclei has a sequential two-step (three-step) character, where, at the first step, a fissile nucleus emits a third light particle (third and fourth light particles) under shakeup effects associated with a nonadiabatic character of its collective deformation motion, whereupon the residual nucleus undergoes fission to two fission fragments. Owing to this, the formulas derived earlier for the widths with respect to sequential two- and three-step decays of nuclei in constructing the theory of two-step twoproton decays and multistep decays in chains of genetically related nuclei could be used to describe the relative yields and angular and energy distributions of third and fourth light particles emitted in (α, α), (t, t), and (α, t) pairs upon the true quaternary spontaneous fission of {sup 252}Cf and thermal-neutron-induced fission of {sup 235}U and {sup 233}U target nuclei. Mechanisms that explain a sharp decrease in the yield of particles appearing second in time and entering into the composition of light-particle pairs that originate from true quaternary fission of nuclei in relation to the yields of analogous particles in true ternary fission of nuclei are proposed.

  11. Impact of Local Item Dependence on True-Score Equating. LSAC Research Report Series.

    ERIC Educational Resources Information Center

    Reese, Lynda M.; Pashley, Peter J.

    This study investigated the practical effects of local item dependence (LID) on item response theory (IRT) true-score equating. A scenario was defined that emulated the Law School Admission Test (LSAT) preequating model, and data were generated to assess the impact of different degrees of LID on final equating outcomes. An extreme amount of LID…

  12. Confessional Discourse and Modern Desires: Power and Pleasure in "True Story" Magazine.

    ERIC Educational Resources Information Center

    Mandziuk, Roseann M.

    2001-01-01

    Traces the roots of the popular culture "commodity confessional" by examining the first five years of the magazine "True Story." Finds the stories fulfilled three functions for the women readers: (1) providing therapeutic messages; (2) providing didactic instruction on proper behavior and modern ways; and (3) serving as interrogative texts which…

  13. A Qualitative Assessment of the My True Body Bariatric Surgery Preparation Program

    ERIC Educational Resources Information Center

    Nakamura, Tracy; Mamary, Edward

    2013-01-01

    Background: The My True Body (MTB) group intervention incorporates cognitive restructuring and social support into bariatric surgery preparation. Purpose: To identify and describe program components that support long-term behavioral modifications and influence confidence in healthy weight maintenance. Methods: Semistructured telephone interviews…

  14. Gender Issues in Gifted Achievement: Are Girls Making Inroads While Boys Fall Behind?

    ERIC Educational Resources Information Center

    Rimm, Sylvia B.

    2015-01-01

    School and life achievement patterns for girls and women differ from those of boys and men. While girls have made dramatic progress in school, they need to be inspired to connect to lifelong achievement. Both research and clinical work at the Ohio-based Family Achievement Clinic find that more boys than girls underachieve in school. There is much…

  15. Molecular analysis in true hermaphrodites with different karyotypes and similar phenotypes

    SciTech Connect

    Torres, L.; Cervantes, A.; Kofman-Alfaro, S.

    1996-05-17

    True hermaphroditism is characterized by the development of ovarian and testicular tissue in the same individual. Muellerian and Wolffian structures are usually present, and external genitalia are often ambiguous. The most frequent karyotype in these patients is 46,XX or various forms of mosaicism, whereas 46,XY is very rarely found. The phenotype in all these subjects is similar. We studied 10 true hermaphrodites. Six of them had a 46,XX chromosomal complement: 3 had been reared as males and 3 as females. The other 4 patients were mosaics: 3 were 46,XX/46,XY and one had a 46,XX/47,XXY karyotype. One of the 46,XX/46,XY mosaics was reared as a female, whereas the other 3 mosaics were reared as males. The sex of assignment in the 10 patients depended only on labio-scrotal differentiation. Molecular studies in 46,XX subjects documented the absence of Y centromeric sequences in all cases, arguing against hidden mosaicism. One patient presented Yp sequences (ZFY+, SRY+), which contrast with South African black 46,XX true hermaphrodites in whom no Y sequences were found. Molecular analysis in the subjects with mosaicism demonstrated the presence of Y centromeric and Yp sequences confirming the presence of a Y chromosome. Gonadal development, endocrine function, and phenotype in the 10 patients did not correlate with the presence of a Y chromosome or Y-derived sequences in the genome, confirming that true hermaphroditism is a heterogeneous condition. Both Mexican and non-South African 46,XX true hermaphrodites may be SRY positive. 51 refs., 3 figs., 2 tabs.

  16. Measurement of true ileal phosphorus digestibility in meat and bone meal for broiler chickens.

    PubMed

    Mutucumarana, R K; Ravindran, V; Ravindran, G; Cowieson, A J

    2015-07-01

    An experiment was conducted to estimate true ileal phosphorus (P:) digestibility of 3 meat and bone meal samples (MBM-1, MBM-2: , and MBM-3:) for broiler chickens. Four semipurified diets were formulated from each sample to contain graded concentrations of P. The experiment was conducted as a completely randomized design with 6 replicates (6 birds per replicate) per dietary treatment. A total of 432 Ross 308 broilers were assigned at 21 d of age to the 12 test diets. The apparent ileal digestibility coefficient of P was determined by the indicator method, and the linear regression method was used to determine the true P digestibility coefficient. The apparent ileal digestibility coefficient of P in birds fed diets containing MBM-1 and MBM-2 was unaffected by increasing dietary concentrations of P (P > 0.05). The apparent ileal digestibility coefficient of P in birds fed the MBM-3 diets decreased with increasing P concentrations (linear, P < 0.001; quadratic, P < 0. 01). In birds fed the MBM-1 and MBM-2 diets, ileal endogenous P losses were estimated to be 0.049 and 0.142 g/kg DM intake (DMI:), respectively. In birds fed the MBM-3 diets, endogenous P loss was estimated to be negative (-0.370 g/kg DMI). True ileal P digestibility of MBM-1, MBM-2, and MBM-3 was determined to be 0.693, 0.608, and 0.420, respectively. True ileal P digestibility coefficients determined for MBM-1 and MBM-2 were similar (P < 0.05), but were higher (P < 0.05) than that for MBM-3. Total P and true digestible P contents of MBM-1, MBM-2, and MBM-3 were determined to be 37.5 and 26.0; 60.2 and 36.6; and 59.8 and 25.1 g/kg, respectively, on an as-fed basis.

  17. An evaluation of a natural language processing tool for identifying and encoding allergy information in emergency department clinical notes.

    PubMed

    Goss, Foster R; Plasek, Joseph M; Lau, Jason J; Seger, Diane L; Chang, Frank Y; Zhou, Li

    2014-01-01

    Emergency department (ED) visits due to allergic reactions are common. Allergy information is often recorded in free-text provider notes; however, this domain has not yet been widely studied by the natural language processing (NLP) community. We developed an allergy module built on the MTERMS NLP system to identify and encode food, drug, and environmental allergies and allergic reactions. The module included updates to our lexicon using standard terminologies, and novel disambiguation algorithms. We developed an annotation schema and annotated 400 ED notes that served as a gold standard for comparison to MTERMS output. MTERMS achieved an F-measure of 87.6% for the detection of allergen names and no known allergies, 90% for identifying true reactions in each allergy statement where true allergens were also identified, and 69% for linking reactions to their allergen. These preliminary results demonstrate the feasibility using NLP to extract and encode allergy information from clinical notes.

  18. Childhood Obesity and Cognitive Achievement.

    PubMed

    Black, Nicole; Johnston, David W; Peeters, Anna

    2015-09-01

    Obese children tend to perform worse academically than normal-weight children. If poor cognitive achievement is truly a consequence of childhood obesity, this relationship has significant policy implications. Therefore, an important question is to what extent can this correlation be explained by other factors that jointly determine obesity and cognitive achievement in childhood? To answer this question, we exploit a rich longitudinal dataset of Australian children, which is linked to national assessments in math and literacy. Using a range of estimators, we find that obesity and body mass index are negatively related to cognitive achievement for boys but not girls. This effect cannot be explained by sociodemographic factors, past cognitive achievement or unobserved time-invariant characteristics and is robust to different measures of adiposity. Given the enormous importance of early human capital development for future well-being and prosperity, this negative effect for boys is concerning and warrants further investigation.

  19. Using Design To Achieve Sustainability

    EPA Science Inventory

    Sustainability is defined as meeting the needs of this generation without compromising the ability of future generations to meet their needs. This is a conditional statement that places the responsibility for achieving sustainability squarely in hands of designers and planners....

  20. Achieving Efficiencies in Army Installations.

    DTIC Science & Technology

    2007-11-02

    34" ’■■"■" 1 USAWC STRATEGY RESEARCH PROJECT Achieving Efficiencies in Army Installations by Richard Fliss Col. Richard M. Meinhart Project...government agency. STRATEGY RESEARCH PROJECT ACHIEVING EFFICIENCIES IN ARMY INSTALLATIONS BY RICHARD FLISS DISTRIBUTION STATEMENT A: Approved...for public release. Distribution is unlimited. DTIC QUALITY INSPECTED & USAWC CLASS OF 1998 U.S. ARMY WAR COLLEGE, CARLISLE BARRACKS, PA 17013-5050

  1. Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy

    PubMed Central

    Huurneman, Luc J.; Neely, Michael; Veringa, Anette; Docobo Pérez, Fernando; Ramos-Martin, Virginia; Tissing, Wim J.; Alffenaar, Jan-Willem C.

    2016-01-01

    Voriconazole is the agent of choice for the treatment of invasive aspergillosis in children at least 2 years of age. The galactomannan index is a routinely used diagnostic marker for invasive aspergillosis and can be useful for following the clinical response to antifungal treatment. The aim of this study was to develop a pharmacokinetic-pharmacodynamic (PK-PD) mathematical model that links the pharmacokinetics of voriconazole with the galactomannan readout in children. Twelve children receiving voriconazole for treatment of proven, probable, and possible invasive fungal infections were studied. A previously published population PK model was used as the Bayesian prior. The PK-PD model was used to estimate the average area under the concentration-time curve (AUC) in each patient and the resultant galactomannan-time profile. The relationship between the ratio of the AUC to the concentration of voriconazole that induced half maximal killing (AUC/EC50) and the terminal galactomannan level was determined. The voriconazole concentration-time and galactomannan-time profiles were both highly variable. Despite this variability, the fit of the PK-PD model was good, enabling both the pharmacokinetics and pharmacodynamics to be described in individual children. (AUC/EC50)/15.4 predicted terminal galactomannan (P = 0.003), and a ratio of >6 suggested a lower terminal galactomannan level (P = 0.07). The construction of linked PK-PD models is the first step in developing control software that enables not only individualized voriconazole dosages but also individualized concentration targets to achieve suppression of galactomannan levels in a timely and optimally precise manner. Controlling galactomannan levels is a first critical step to maximizing clinical response and survival. PMID:26833158

  2. What's the gist? The influence of schemas on the neural correlates underlying true and false memories.

    PubMed

    Webb, Christina E; Turney, Indira C; Dennis, Nancy A

    2016-12-01

    The current study used a novel scene paradigm to investigate the role of encoding schemas on memory. Specifically, the study examined the influence of a strong encoding schema on retrieval of both schematic and non-schematic information, as well as false memories for information associated with the schema. Additionally, the separate roles of recollection and familiarity in both veridical and false memory retrieval were examined. The study identified several novel results. First, while many common neural regions mediated both schematic and non-schematic retrieval success, schematic recollection exhibited greater activation in visual cortex and hippocampus, regions commonly shown to mediate detailed retrieval. More effortful cognitive control regions in the prefrontal and parietal cortices, on the other hand, supported non-schematic recollection, while lateral temporal cortices supported familiarity-based retrieval of non-schematic items. Second, both true and false recollection, as well as familiarity, were mediated by activity in left middle temporal gyrus, a region associated with semantic processing and retrieval of schematic gist. Moreover, activity in this region was greater for both false recollection and false familiarity, suggesting a greater reliance on lateral temporal cortices for retrieval of illusory memories, irrespective of memory strength. Consistent with previous false memory studies, visual cortex showed increased activity for true compared to false recollection, suggesting that visual cortices are critical for distinguishing between previously viewed targets and related lures at retrieval. Additionally, the absence of common visual activity between true and false retrieval suggests that, unlike previous studies utilizing visual stimuli, when false memories are predicated on schematic gist and not perceptual overlap, there is little reliance on visual processes during false memory retrieval. Finally, the medial temporal lobe exhibited an

  3. A True Eddy Accumulation - Eddy Covariance hybrid for measurements of turbulent trace gas fluxes

    NASA Astrophysics Data System (ADS)

    Siebicke, Lukas

    2016-04-01

    Eddy covariance (EC) is state-of-the-art in directly and continuously measuring turbulent fluxes of carbon dioxide and water vapor. However, low signal-to-noise ratios, high flow rates and missing or complex gas analyzers limit it's application to few scalars. True eddy accumulation, based on conditional sampling ideas by Desjardins in 1972, requires no fast response analyzers and is therefore potentially applicable to a wider range of scalars. Recently we showed possibly the first successful implementation of True Eddy Accumulation (TEA) measuring net ecosystem exchange of carbon dioxide of a grassland. However, most accumulation systems share the complexity of having to store discrete air samples in physical containers representing entire flux averaging intervals. The current study investigates merging principles of eddy accumulation and eddy covariance, which we here refer to as "true eddy accumulation in transient mode" (TEA-TM). This direct flux method TEA-TM combines true eddy accumulation with continuous sampling. The TEA-TM setup is simpler than discrete accumulation methods while avoiding the need for fast response gas analyzers and high flow rates required for EC. We implemented the proposed TEA-TM method and measured fluxes of carbon dioxide (CO2), methane (CH4) and water vapor (H2O) above a mixed beech forest at the Hainich Fluxnet and ICOS site, Germany, using a G2301 laser spectrometer (Picarro Inc., USA). We further simulated a TEA-TM sampling system using measured high frequency CO2 time series from an open-path gas analyzer. We operated TEA-TM side-by-side with open-, enclosed- and closed-path EC flux systems for CO2, H2O and CH4 (LI-7500, LI-7200, LI-6262, LI-7700, Licor, USA, and FGGA LGR, USA). First results show that TEA-TM CO2 fluxes were similar to EC fluxes. Remaining differences were similar to those between the three eddy covariance setups (open-, enclosed- and closed-path gas analyzers). Measured TEA-TM CO2 fluxes from our physical

  4. Commissioning of the Varian TrueBeam linear accelerator: A multi-institutional study

    SciTech Connect

    Glide-Hurst, C.; Bellon, M.; Wen, N.; Zhao, B.; Chetty, I. J.; Foster, R.; Speiser, M.; Solberg, T.; Altunbas, C.; Westerly, D.; Miften, M.; Altman, M.

    2013-03-15

    Purpose: Latest generation linear accelerators (linacs), i.e., TrueBeam (Varian Medical Systems, Palo Alto, CA) and its stereotactic counterpart, TrueBeam STx, have several unique features, including high-dose-rate flattening-filter-free (FFF) photon modes, reengineered electron modes with new scattering foil geometries, updated imaging hardware/software, and a novel control system. An evaluation of five TrueBeam linacs at three different institutions has been performed and this work reports on the commissioning experience. Methods: Acceptance and commissioning data were analyzed for five TrueBeam linacs equipped with 120 leaf (5 mm width) MLCs at three different institutions. Dosimetric data and mechanical parameters were compared. These included measurements of photon beam profiles (6X, 6XFFF, 10X, 10XFFF, 15X), photon and electron percent depth dose (PDD) curves (6, 9, 12 MeV), relative photon output factors (Scp), electron cone factors, mechanical isocenter accuracy, MLC transmission, and dosimetric leaf gap (DLG). End-to-end testing and IMRT commissioning were also conducted. Results: Gantry/collimator isocentricity measurements were similar (0.27-0.28 mm), with overall couch/gantry/collimator values of 0.46-0.68 mm across the three institutions. Dosimetric data showed good agreement between machines. The average MLC DLGs for 6, 10, and 15 MV photons were 1.33 {+-} 0.23, 1.57 {+-} 0.24, and 1.61 {+-} 0.26 mm, respectively. 6XFFF and 10XFFF modes had average DLGs of 1.16 {+-} 0.22 and 1.44 {+-} 0.30 mm, respectively. MLC transmission showed minimal variation across the three institutions, with the standard deviation <0.2% for all linacs. Photon and electron PDDs were comparable for all energies. 6, 10, and 15 MV photon beam quality, %dd(10){sub x} varied less than 0.3% for all linacs. Output factors (Scp) and electron cone factors agreed within 0.27%, on average; largest variations were observed for small field sizes (1.2% coefficient of variation, 10 MV, 2

  5. Monte Carlo validation of the TrueBeam 10XFFF phase–space files for applications in lung SABR

    SciTech Connect

    Teke, Tony; Duzenli, Cheryl; Bergman, Alanah; Viel, Francis; Atwal, Parmveer; Gete, Ermias

    2015-12-15

    Purpose: To establish the clinical acceptability of universal Monte Carlo phase–space data for the 10XFFF (flattening filter free) photon beam on the Varian TrueBeam Linac, including previously unreported data for small fields, output factors, and inhomogeneous media. The study was particularly aimed at confirming the suitability for use in simulations of lung stereotactic ablative radiotherapy treatment plans. Methods: Monte Carlo calculated percent depth doses (PDDs), transverse profiles, and output factors for the TrueBeam 10 MV FFF beam using generic phase–space data that have been released by the Varian MC research team were compared with in-house measurements and published data from multiple institutions (ten Linacs from eight different institutions). BEAMnrc was used to create field size specific phase–spaces located underneath the jaws. Doses were calculated with DOSXYZnrc in a water phantom for fields ranging from 1 × 1 to 40 × 40 cm{sup 2}. Particular attention was paid to small fields (down to 1 × 1 cm{sup 2}) and dose per pulse effects on dosimeter response for high dose rate 10XFFF beams. Ion chamber measurements were corrected for changes in ion collection efficiency (P{sub ion}) with increasing dose per pulse. MC and ECLIPSE ANISOTROPIC ANALYTICAL ALGORITHM (AAA) calculated PDDs were compared to Gafchromic film measurement in inhomogeneous media (water, bone, lung). Results: Measured data from all machines agreed with Monte Carlo simulations within 1.0% and 1.5% for PDDs and in-field transverse profiles, respectively, for field sizes >1 × 1 cm{sup 2} in a homogeneous water phantom. Agreements in the 80%–20% penumbra widths were better than 2 mm for all the fields that were compared. For all the field sizes considered, the agreement between their measured and calculated output factors was within 1.1%. Monte Carlo results for dose to water at water/bone, bone/lung, and lung/water interfaces as well as within lung agree with film

  6. Disinhibition of negative true self for identity reconstructions in cyberspace: Advancing self-discrepancy theory for virtual setting.

    PubMed

    Hu, Chuan; Kumar, Sameer; Huang, Jiao; Ratnavelu, Kurunathan

    2017-01-01

    In face-to-face communications, to avoid sanctions and disapproval from others, people are more likely to hide negative aspects of their true self (such as socially undesirable personalities, minds, beliefs and consciousness) to avoid conflict with social norms and laws. The anonymity of cyberspace provides people a unique environment to behave more freely and openly with less restraint from the real word. Existing research related to online true self expression has mainly explored true self as an independent aspect of self. Regarding true self as a two-dimensional concept, this study investigates true self from the perspective of individuals' self-guide and identity reconstruction in both online and offline world. Using qualitative research methods, the current study investigates 57 participants through interviews and questionnaires. Content analysis reveals four factors that motivate people to express more true self (especially negative true self) when reconstructing their online identity and involve true self as a part of their self-guide in anonymous environment. By incorporating true self as an important part of individuals' self-guide and identity online, the current study advances self-discrepancy theory, making it more comprehensive for cyberspace. The results are also interpreted based on self-determination theory. The theoretical contributions of this study are discussed and practical implications are also presented.

  7. The Theory of Artificial Satellites in Terms of the Orbital True Longitude

    NASA Technical Reports Server (NTRS)

    Musen, Peter

    1961-01-01

    The author's previous theory of the artificial satellite is derived in terms of the. disturbed eccentric anomaly. The present development, in terms of the orbital true longitude, is a substantial improvement over the earlier work in that it leads to the faster convergence for large eccentricities and to a smaller number of terms in the series representing the perturbations. Moreover, each approximation of the radius vector and of the parameters determining the position of the orbit plane is obtained not in the form of a truncated infinite series but in the form of trigonometric polynomials in two arguments. These arguments are the mean true anomaly and the mean argument of the latitude. The present theory, like the previous one, permits the computation of perturbations of any desired order. Thus, any future information about earth's gravitational field can easily be included.

  8. True (but not false) memories are subject to retrieval-induced forgetting in children.

    PubMed

    Price, Heather L; Phenix, Thomas L

    2015-05-01

    Veridical and false memories of children aged 6 to 15 years were studied in two experiments with the retrieval-induced forgetting paradigm. Using the Deese-Roediger-McDermott (DRM) false memory word lists, children's reports of true, but not false, memories showed evidence of retrieval-induced forgetting. These differences were observed across delays as long as 2 days following word list presentation. The lack of observation of retrieval-induced forgetting in children's false memories provides evidence that a key assumption in the theory of retrieval-induced forgetting, cue independence, might not consistently apply. These experiments underscore the need for both practical and theoretically motivated study of true and false memories.

  9. Limited true polar wander as evidence that Earth's nonhydrostatic shape is persistently triaxial

    NASA Astrophysics Data System (ADS)

    Steinberger, Bernhard; Seidel, Miriam-Lisanne; Torsvik, Trond H.

    2017-01-01

    Earth's spin axis follows the maximum moment of inertia axis of mantle convection, with some delay due to adjustment of the rotational bulge. Here we compute this axis for geodynamic models based on subduction history, assuming constant slab sinking speed, with another contribution due to thermochemical piles. For a wide range of parameters, a large shift of ≈90° is predicted around 80-90 Ma. It can be largely attributed to a change in circum-Pacific subduction from predominantly in the North and South toward East and West. Actual amounts of true polar wander are much smaller, pointing toward additional inertia tensor contributions, possibly due to slabs in the lowermost mantle below both polar regions. These slabs would have been subducted before ≈150 Ma, when plate motions in the Panthalassa basin are largely unknown. Matching predicted and observed true polar wander can serve at constraining such plate motions.

  10. Detecting children's lies: comparing true accounts about highly stressful injuries with unprepared, prepared, and coached lies.

    PubMed

    Warren, Kelly L; Dodd, Elyse; Raynor, Graham; Peterson, Carole

    2012-01-01

    In this investigation, 514 university students judged whether children were telling the truth about highly emotional events. Eight children (half female, half 8-9 and the remainder 12-14 years old) had been injured seriously enough to require emergency room treatment and were interviewed a few days later. Each was yoked to three other children matched in age and gender who fabricated accounts under one of three conditions: lies that were unprepared, prepared (24 hours to prepare), and coached by parents. Participants were at chance when judging true accounts as well as unprepared and prepared lies. However, 74% of the coached lies were judged as true. Participants' confidence in their judgments, age, experience with children, and relevant coursework/training did not improve judgments.

  11. Can maltreated children inhibit true and false memories for emotional information?

    PubMed

    Howe, Mark L; Toth, Sheree L; Cicchetti, Dante

    2011-01-01

    The authors examined 284 maltreated and nonmaltreated children's (6- to 12-year-olds) ability to inhibit true and false memories for neutral and emotional information using the Deese/Roediger-McDermott (DRM) paradigm. Children studied either emotional or neutral DRM lists in a control condition or were given directed-remembering or directed-forgetting instructions. The findings indicated that children, regardless of age and maltreatment status, could inhibit the output of true and false emotional information, although they did so less effectively than when they were inhibiting the output of neutral material. Verbal IQ was related to memory, but dissociative symptoms were not related to children's recollective ability. These findings add to the growing literature that shows more similarities among, than differences between, maltreated and nonmaltreated children's basic memory processes.

  12. Can Maltreated Children Inhibit True and False Memories for Emotional Information?

    PubMed Central

    Howe, Mark L.; Toth, Sheree L.; Cicchetti, Dante

    2011-01-01

    The authors examined 284 maltreated and nonmaltreated children’s (6- to 12-year-olds) ability to inhibit true and false memories for neutral and emotional information using the Deese/Roediger-McDermott (DRM) paradigm. Children studied either emotional or neutral DRM lists in a control condition or were given directed-remembering or directed-forgetting instructions. The findings indicated that children, regardless of age and maltreatment status, could inhibit the output of true and false emotional information, although they did so less effectively than when they were inhibiting the output of neutral material. Verbal IQ was related to memory, but dissociative symptoms were not related to children’s recollective ability. These findings add to the growing literature that shows more similarities among, than differences between, maltreated and nonmaltreated children’s basic memory processes. PMID:21428984

  13. BWR (boiling water reactor) lattice analysis using true geometry as compared to CPM-2

    SciTech Connect

    Knott, D.; Baratta, A. )

    1989-11-01

    Conventional lattice physics codes perform the two-dimensional transport calculation using an approximated geometry, whereby all pin cells are homogenized following the spectral calculations. To better calculate the true flux within the gadolinia cells, the two-dimensional transport calculation is performed in the true geometry of the lattice using KRAM, a two-dimensional characteristics solution of the transport equation. Normal fuel cells are modeled using three regions (cylindrical fuel and clad regions within a square moderator region), while fuel regions containing gad are subdivided into many annular subregions, thereby better approximating the self-shielding effect of the gad. The characteristics method breaks the system being analyzed into regions of constant flux, as in collision probability methods, and it is, therefore, desirable to minimize the size of these regions. To this end, then, each pin cell is further subdivided diagonally into quadrants.

  14. A geometrical model for the Monte Carlo simulation of the TrueBeam linac.

    PubMed

    Rodriguez, M; Sempau, J; Fogliata, A; Cozzi, L; Sauerwein, W; Brualla, L

    2015-06-07

    Monte Carlo simulation of linear accelerators (linacs) depends on the accurate geometrical description of the linac head. The geometry of the Varian TrueBeam linac is not available to researchers. Instead, the company distributes phase-space files of the flattening-filter-free (FFF) beams tallied at a plane located just upstream of the jaws. Yet, Monte Carlo simulations based on third-party tallied phase spaces are subject to limitations. In this work, an experimentally based geometry developed for the simulation of the FFF beams of the Varian TrueBeam linac is presented. The Monte Carlo geometrical model of the TrueBeam linac uses information provided by Varian that reveals large similarities between the TrueBeam machine and the Clinac 2100 downstream of the jaws. Thus, the upper part of the TrueBeam linac was modeled by introducing modifications to the Varian Clinac 2100 linac geometry. The most important of these modifications is the replacement of the standard flattening filters by ad hoc thin filters. These filters were modeled by comparing dose measurements and simulations. The experimental dose profiles for the 6 MV and 10 MV FFF beams were obtained from the Varian Golden Data Set and from in-house measurements performed with a diode detector for radiation fields ranging from 3  ×  3 to 40  ×  40 cm(2) at depths of maximum dose of 5 and 10 cm. Indicators of agreement between the experimental data and the simulation results obtained with the proposed geometrical model were the dose differences, the root-mean-square error and the gamma index. The same comparisons were performed for dose profiles obtained from Monte Carlo simulations using the phase-space files distributed by Varian for the TrueBeam linac as the sources of particles. Results of comparisons show a good agreement of the dose for the ansatz geometry similar to that obtained for the simulations with the TrueBeam phase-space files for all fields and depths considered, except for

  15. [A case of true neurogenic thoracic outlet syndrome accompanied by an aberrant right subclavian artery].

    PubMed

    Sekiguchi, Kenji; Saito, Takanori; Yokota, Ichiro; Kowa, Hisatomo; Kanda, Fumio; Toda, Tatsushi

    2015-01-01

    A 65-year-old woman experienced progressive intrinsic muscle wasting on the right hand over a period of 7 years. The distribution of muscular atrophy and weakness was consistent with the area innervated by the right C8 and Th1 nerve roots. Neurophysiological examination suggested a right lower trunk lesion. An elongated right transverse process of the C7 vertebra and an aberrant subclavian artery were detected on computed tomography images, and the right lower trunk of the brachial plexus appeared to be lifted upward on magnetic resonance images. The patient was diagnosed with true neurogenic thoracic outlet syndrome. A fibrous band extending from the elongated transverse process was found during surgery, and symptoms did not progress further after resection of the band. True neurogenic thoracic outlet syndrome can cause monomelic amyotrophy, and localized neuroimaging and detailed neurophysiological examination were useful for diagnosis.

  16. Fiber optic Bragg grating true-time-delay generator for broadband rf applications

    NASA Astrophysics Data System (ADS)

    Wickham, Michael G.; Lembo, Lawrence J.; Dozal, Lawrence A.; Brock, John C.

    1996-11-01

    A fiber-optic approach for low-loss true time delay of wideband RF signals for phased-array-antenna beamsteering is presented. An optical carrier modulated by the RF signal of interest is launched into a delay-line fiber composed of optical Bragg reflection gratings written holographically into the core of a single-mode fiber. The desired beam steering is realized by tuning the optical carrier wavelength for reflection from the appropriate grating. Radiation testing of various fibers with Bragg gratings has been performed indicating preferable fiber types. True time delay offers much reduced beam squint and sharper antenna superior nulling compared to phase shift scanned antenna. Examples of applications of this concept showing its advantages are presented.

  17. Inflammatory myofibroblastic tumour of the lung: a reactive lesion or a true neoplasm?

    PubMed Central

    Panagiotopoulos, Nikolaos; Gvinianidze, Lasha; Woo, Wen Ling; Borg, Elaine; Lawrence, David

    2015-01-01

    Inflammatory myofibroblastic tumour (IMT) of the lung represents an extremely rare type of inflammatory pseudo tumor that appears most commonly in children and young individuals. There has been an ongoing controversy whether an IMT is a reactive lesion or a true neoplasm making the further management extremely challenging. Purpose of the paper is through a literature review to highlight the existence of this rare tumour along with its key features and the management options available. PMID:26101648

  18. Deriving the True Mass of an Unresolved Brown Dwarf Companion with AO Aided Astrometry

    NASA Astrophysics Data System (ADS)

    Meyer, Eva; Kürster, M.

    2010-01-01

    From radial velocity detections alone one does not get all orbital parameters needed to derive the true mass of a non-transiting, unresolved substellar companion to a star. Additional astrometric measurements are needed to calculate the inclination and the longitude of the ascending node. Until today only few true companion masses have been determined by this method with the HST fine guidance sensor (Benedict 2006, Benedict 2002). We aim to derive the true mass of a brown dwarf candidate companion to an early M 2.5V dwarf with groundbased high-resolution astrometry aided by adaptive optics. We found this unique brown dwarf desert object, which distance to the host star is only 0.42 AU, in our UVES precision radial velocity survey of M dwarfs, inferring a minimum companion mass of 27 Jupiter masses (Kuerster 2008). Combining the data with HIPPARCOS astrometry, we found a probability of only 2.9% that the companion is stellar. We are therefore observing the host star and a reference star within a monitoring program with VLT/NACO to derive the true mass of the companion and establish its nature (BD vs. star). Simultaneous observations of a reference field in a globular cluster are performed to determine the stability of the AO plus detector system and check its suitability for such high-precision astrometric measurements over several epochs which are needed to find and analyse extrasolar planet systems. We present preliminary results of the analysis of the astrometric displacements of the host star due to the unseen companion after correcting for differential refraction and differential aberration, as well as a first orbit fit and mass estimation.

  19. The true fluence distribution of terrestrial gamma flashes at satellite altitude

    NASA Astrophysics Data System (ADS)

    ØStgaard, N.; Gjesteland, T.; Hansen, R. S.; Collier, A. B.; Carlson, B.

    2012-03-01

    In this paper we use the fluence distributions observed by two different instruments, RHESSI and Fermi GBM, corrected for the effects of their different orbits, combined with their different daily TGF detection rates and their relative sensitivities to make an estimate of the true fluence distribution of TGFs as measured at satellite altitudes. The estimate is then used to calculate the dead-time loss for an average TGF measured by RHESSI. An independent estimate of RHESSI dead-time loss and true fluence distribution is obtained from a Monte Carlo (MC) simulation in order to evaluate the consistency of our results. The two methods give RHESSI dead-time losses of 24-26% for average fluence of 33-35 counts. Assuming a sharp cut-off the true TGF fluence distribution is found to follow a power law with λ = 2.3 ± 0.2 down to ˜5/600 of the detection threshold of RHESSI. This corresponds to a lowest number of electrons produced in a TGF of ˜1014 and a global production rate within ±38° latitude of 50000 TGFs/day or about 35 TGFs every minute, which is 2% of all IC lightning. If a more realistic distribution with a roll-off below 1/3 (or higher) of the RHESSI lower detection threshold with a true distribution with λ ≤ 1.7 that corresponds to a source distribution with λ ≤ 1.3 is considered, we can not rule out that all discharges produce TGFs. In that case the lowest number of total electrons produced in a TGF is ˜1012.

  20. Development and demonstration of the Westinghouse hardware-compressive true time delay (TTD) fiber optic system

    NASA Astrophysics Data System (ADS)

    Goutzoulis, Anastasios P.; Davies, D. Kenneth; Zomp, John M.; Hrycak, Peter; Johnson, Andy

    1994-06-01

    We describe the development and antenna range demonstration of the Westinghouse fiber optic wavelength-multiplexed true time delay steering system for use with broadband phased array antennas. The prototype system is based on a unique hardware compressive architecture and can drive 16 antenna elements over the 0.32 to 2.1 GHz band with 6-bit angular resolution over a +/- 45 degree(s) scan angle.

  1. Two sources of evidence on the non-automaticity of true and false belief ascription.

    PubMed

    Back, Elisa; Apperly, Ian A

    2010-04-01

    A recent study by Apperly et al. (2006) found evidence that adults do not automatically infer false beliefs while watching videos that afford such inferences. This method was extended to examine true beliefs, which are sometimes thought to be ascribed by "default" (e.g., Leslie & Thaiss, 1992). Sequences of pictures were presented in which the location of an object and a character's belief about the location of the object often changed. During the picture sequences participants responded to an unpredictable probe picture about where the character believed the object to be located or where the object was located in reality. In Experiment 1 participants were not directly instructed to track the character's beliefs about the object. There was a significant reaction time cost for belief probes compared with matched reality probes, whether the character's belief was true or false. In Experiment 2, participants were asked to track where the character thought the object was located, responses to belief probes were faster than responses to reality probes, suggesting that the difference observed in Experiment 1 was not due to intrinsic differences between the probes, but was more likely to be due to participants inferring beliefs ad hoc in response to the probe. In both Experiments 1 and 2, responses to belief and reality probes were faster in the true belief condition than in the false belief condition. In Experiment 3 this difference was largely eliminated when participants had fewer reasons to make belief inferences spontaneously. These two lines of evidence are neatly explained by the proposition that neither true nor false beliefs are ascribed automatically, but that belief ascription may occur spontaneously in response to task demands.

  2. Childhood vaccination: achievements and challenges.

    PubMed

    Ndumbe, P

    1996-09-01

    As the goal of eradicating smallpox was being met, the World Health Organization created its Expanded Programme on Immunisation (EPI) in 1974 and reached its initial goal of achieving full vaccination of 80% of the world's children by 1990. This effort was aided by the creation of "cold chain" delivery systems and resulted in the annual saving of 3.5 million children in less-developed countries. Current EPI vaccination goals include 1) eradication of poliomyelitis by the year 2000, 2) elimination of neonatal tetanus by the year 1995, 3) control of measles and hepatitis B, and 4) immunization of 90% of the world's children 1 year or younger by the year 2000. Goals of the Children's Vaccine Initiative (formed in 1991) include 1) provision of an adequate supply of affordable, safe, and effective vaccines; 2) production of improved and new vaccines; and 3) simplification of the logistics of vaccine delivery. Future challenges are to sustain high vaccination coverage, reach the unreached, achieve proper storage of vaccines and reduce waste, integrate new vaccines into national programs, and achieve vaccine self-sufficiency. The fact that these challenges will be difficult to achieve is illustrated by the situation in Africa where the high immunization levels achieved in 1990 have dropped dramatically. Those who must act to implement immunization programs are health personnel, families, governments, and development partners. In order to achieve equity in health, every child must be reached, governments must be made accountable for programs, health workers must convince families of the importance of vaccination, delivery systems must be in place to take advantage of the new vaccines being delivered, and a multisectoral approach must be taken to assure sustainability.

  3. True-time-delay transmit/receive optical beam-forming system for phased arrays and other signal processing applications

    NASA Astrophysics Data System (ADS)

    Toughlian, Edward N.; Zamuda, H.; Carter, Charity A.

    1994-06-01

    This paper addresses the problem of dynamic optical processing for the control of phased array antennas. The significant result presented is the demonstration of a continuously variable photonic RF/microwave delay line. Specifically, it is shown that by applying spatial frequency dependent optical phase compensation in an optical heterodyne process, variable RF delay can be achieved over a prescribed frequency band. Experimental results which demonstrate the performance of the delay line with regard to both maximum delay and resolution over a broad bandwidth are presented. Additionally, a spatially integrated optical system is proposed for control of phased array antennas. The integrated system provides mechanical stability, essentially eliminates the drift problems associated with free space optical systems, and can provide high packing density. This approach uses a class of spatial light modulator known as a deformable mirror device and leads to a steerable arbitrary antenna radiation pattern of the true time delay type. Also considered is the ability to utilize the delay line as a general photonic signal processing element in an adaptive (reconfigurable) transversal frequency filter configuration. Such systems are widely applicable in jammer/noise canceling systems, broadband ISDN, spread spectrum secure communications and the like.

  4. Materials and fabrication of electrode scaffolds for deposition of MnO2 and their true performance in supercapacitors

    NASA Astrophysics Data System (ADS)

    Cao, Jianyun; Li, Xiaohong; Wang, Yaming; Walsh, Frank C.; Ouyang, Jia-Hu; Jia, Dechang; Zhou, Yu

    2015-10-01

    MnO2 is a promising electrode material for high energy supercapacitors because of its large pseudo-capacitance. However, MnO2 suffers from low electronic conductivity and poor cation diffusivity, which results in poor utilization and limited rate performance of traditional MnO2 powder electrodes, obtained by pressing a mixed paste of MnO2 powder, conductive additive and polymer binder onto metallic current collectors. Developing binder-free MnO2 electrodes by loading nanoscale MnO2 deposits on pre-fabricated device-ready electrode scaffolds is an effective way to achieve both high power and energy performance. These electrode scaffolds, with interconnected skeletons and pore structures, will not only provide mechanical support and electron collection as traditional current collectors but also fast ion transfer tunnels, leading to high MnO2 utilization and rate performance. This review covers design strategies, materials and fabrication methods for the electrode scaffolds. Rational evaluation of the true performance of these electrodes is carried out, which clarifies that some of the electrodes with as-claimed exceptional performances lack potential in practical applications due to poor mass loading of MnO2 and large dead volume of inert scaffold materials/void spaces in the electrode structure. Possible ways to meet this challenge and bring MnO2 electrodes from laboratory studies to real-world applications are considered.

  5. An experimental displacement and over 50 years of tag-recoveries show that monarch butterflies are not true navigators.

    PubMed

    Mouritsen, Henrik; Derbyshire, Rachael; Stalleicken, Julia; Mouritsen, Ole Ø; Frost, Barrie J; Norris, D Ryan

    2013-04-30

    Monarch butterflies (Danaus plexippus) breeding in eastern North America are famous for their annual fall migration to their overwintering grounds in Mexico. However, the mechanisms they use to successfully reach these sites remain poorly understood. Here, we test whether monarchs are true navigators who can determine their location relative to their final destination using both a "compass" and a "map". Using flight simulators, we recorded the orientation of wild-caught monarchs in southwestern Ontario and found that individuals generally flew in a southwest direction toward the wintering grounds. When displaced 2,500 km to the west, the same individuals continued to fly in a general southwest direction, suggesting that monarchs use a simple vector-navigation strategy (i.e., use a specific compass bearing without compensating for displacement). Using over 5 decades of field data, we also show that the directional concentration and the angular SD of recoveries from tagged monarchs largely conformed to two mathematical models describing the directional distribution of migrants expected under a vector-navigation strategy. A third analysis of tagged recoveries shows that the increasing directionality of migration from north to south is largely because of the presence of geographic barriers that guide individuals toward overwintering sites. Our work suggests that monarchs breeding in eastern North America likely combine simple orientation mechanisms with geographic features that funnel them toward Mexican overwintering sites, a remarkable achievement considering that these butterflies weigh less than a gram and travel thousands of kilometers to a site they have never seen.

  6. Molecular cloning and heterologous expression of a true lipase in Pichia pastoris isolated via a metagenomic approach.

    PubMed

    Zheng, Jianhua; Liu, Liguo; Liu, Cuina; Jin, Qi

    2012-01-01

    Lipases are important enzymes for various biotechnological applications. By using functional expression screening, lipZ03, a novel lipase gene, was isolated from a soil-derived metagenomic library. The gene was supposed to encode a protein of 617 amino acids with a C-terminal targeting signal region and four potential N-linked glycosylation sites. The protein sequence shared a conserved GXSXG motif (X represents any amino acid residue) with other microbial lipases. Gene lipZ03 was expressed in Pichia pastoris and the molecular weight was estimated to be approximately 65 kDa by electrophoresis. The optimum reaction temperature and pH value for LipZ03 was 50°C and 9.0, respectively. The enzyme was highly stable in the temperature range of 40-60°C and under alkaline conditions (pH 8-10). Lipolytic activity was significantly enhanced by Ca(2+) and Mg(2+) ions, but dramatically inhibited by Cu(2+), Ni(2+) and Hg(2+) ions and EDTA. The purified enzyme preferentially hydrolyzed relatively long-chain triacylglycerols and was a true lipase rather than an esterase. Using a multi-stepwise methanol supply, the purified LipZ03 achieved a conversion yield of biodiesel production up to 74% after 36 h. Some interesting characteristics described here showed that the recombinant lipase may have potential to be a useful enzyme in industrial applications.

  7. Experimental Study of Slabbing and Rockburst Induced by True-Triaxial Unloading and Local Dynamic Disturbance

    NASA Astrophysics Data System (ADS)

    Du, Kun; Tao, Ming; Li, Xi-bing; Zhou, Jian

    2016-09-01

    Slabbing/spalling and rockburst are unconventional types of failure of hard rocks under conditions of unloading and various dynamic loads in environments with high and complex initial stresses. In this study, the failure behaviors of different rock types (granite, red sandstone, and cement mortar) were investigated using a novel testing system coupled to true-triaxial static loads and local dynamic disturbances. An acoustic emission system and a high-speed camera were used to record the real-time fracturing processes. The true-triaxial unloading test results indicate that slabbing occurred in the granite and sandstone, whereas the cement mortar underwent shear failure. Under local dynamically disturbed loading, none of the specimens displayed obvious fracturing at low-amplitude local dynamic loading; however, the degree of rock failure increased as the local dynamic loading amplitude increased. The cement mortar displayed no failure during testing, showing a considerable load-carrying capacity after testing. The sandstone underwent a relatively stable fracturing process, whereas violent rockbursts occurred in the granite specimen. The fracturing process does not appear to depend on the direction of local dynamic loading, and the acoustic emission count rate during rock fragmentation shows that similar crack evolution occurred under the two test scenarios (true-triaxial unloading and local dynamically disturbed loading).

  8. Hiding true emotions: micro-expressions in eyes retrospectively concealed by mouth movements.

    PubMed

    Iwasaki, Miho; Noguchi, Yasuki

    2016-02-26

    When we encounter someone we dislike, we may momentarily display a reflexive disgust expression, only to follow-up with a forced smile and greeting. Our daily lives are replete with a mixture of true and fake expressions. Nevertheless, are these fake expressions really effective at hiding our true emotions? Here we show that brief emotional changes in the eyes (micro-expressions, thought to reflect true emotions) can be successfully concealed by follow-up mouth movements (e.g. a smile). In the same manner as backward masking, mouth movements of a face inhibited conscious detection of all types of micro-expressions in that face, even when viewers paid full attention to the eye region. This masking works only in a backward direction, however, because no disrupting effect was observed when the mouth change preceded the eye change. These results provide scientific evidence for everyday behaviours like smiling to dissemble, and further clarify a major reason for the difficulty we face in discriminating genuine from fake emotional expressions.

  9. True manganese absorption in chicks as affected by dietary excesses of calcium and phosphorus

    SciTech Connect

    Wedekind, K.J.; Titgemeyer, E.C.; Twardock, A.R.; Baker, D.H. )

    1991-03-15

    Two balance studies with growing chicks were conducted to evaluate the effects of excess calcium (Ca) or excess phosphorus (P) on endogenous fecal manganese (Mn) excretion and true Mn absorption determined using an isotope-dilution technique. Supplements were added to a corn-soybean meal diet containing 1% Ca, 0.7% P and 37 mg/kg Mn. In Exp. 1, supplemental Ca levels of 0, 0.5 and 1.0% from feedgrade limestone were compared. True absorption of Mn was not affected by Ca level and averaged 2.8% for birds fed the Mn-unsupplemented diet. In Exp. 2, a 2 x 3 factorial arrangement of treatments included: 100 and 1,000 mg/kg supplemental Mn and 0, 0.4 and 0.8% added P supplied by dicalcium phosphate. Excess P decreased true absorption of Mn. In birds fed 100 mg/kg supplemental Mn, absorption of Mn decreased 22% as excess P increased from 0 to 0.8%, whereas in birds fed 1,000 mg/kg supplemental Mn, Mn absorption decreased 58% as a result of 0.8% P supplementation. These results confirm that excess Ca has little effect while excess P has a marked effect on gut absorption of Mn.

  10. Adaptive memory: Survival processing increases both true and false memory in adults and children.

    PubMed

    Otgaar, Henry; Smeets, Tom

    2010-07-01

    Research has shown that processing information in a survival context can enhance the information's memorability. The current study examined whether survival processing can also decrease the susceptibility to false memories and whether the survival advantage can be found in children. In Experiment 1, adults rated semantically related words in a survival, moving, or pleasantness scenario. Even though the survival advantage was demonstrated for true recall, there also was an unexpected increase in false memories in the survival condition. Similarly, younger and older children in Experiment 2 displayed superior true recall but also higher rates of false memories in a survival condition. Experiment 3 showed that in adults false memories were also more likely to occur in the survival condition when categorized lists instead of Deese-Roediger-McDermott (DRM)-like word lists were used. In all three experiments, no survival recall advantage was found when net accuracy scores that take the total output into account were used. These findings question whether survival processing is an adaptive memory strategy per se, as such processing not only enriches true recall but simultaneously amplifies the vulnerability to false memories.

  11. New approach to calculate the true-coincidence effect of HpGe detector

    SciTech Connect

    Alnour, I. A. E-mail: ibrahim.elnour@yahoo.com; Wagiran, H.; Ibrahim, N.; Hamzah, S.; Elias, M. S.; Siong, W. B.

    2016-01-22

    The corrections for true-coincidence effects in HpGe detector are important, especially at low source-to-detector distances. This work established an approach to calculate the true-coincidence effects experimentally for HpGe detectors of type Canberra GC3018 and Ortec GEM25-76-XLB-C, which are in operation at neutron activation analysis lab in Malaysian Nuclear Agency (NM). The correction for true-coincidence effects was performed close to detector at distances 2 and 5 cm using {sup 57}Co, {sup 60}Co, {sup 133}Ba and {sup 137}Cs as standard point sources. The correction factors were ranged between 0.93-1.10 at 2 cm and 0.97-1.00 at 5 cm for Canberra HpGe detector; whereas for Ortec HpGe detector ranged between 0.92-1.13 and 0.95-100 at 2 and 5 cm respectively. The change in efficiency calibration curve of the detector at 2 and 5 cm after correction was found to be less than 1%. Moreover, the polynomial parameters functions were simulated through a computer program, MATLAB in order to find an accurate fit to the experimental data points.

  12. Age-related Differences in Brain Activity during True and False Memory Retrieval

    PubMed Central

    Dennis, Nancy A.; Kim, Hongkeun; Cabeza, Roberto

    2010-01-01

    Compared to young adults, older adults show not only a reduction in true memories but also an increase in false memories. We investigated the neural bases of these age effects using functional magnetic resonance imaging and a false memory task that resembles the Deese–Roediger–McDermott (DRM) paradigm. Young and older participants were scanned during a word recognition task that included studied words and new words that were strongly associated with studied words (critical lures). During correct recognition of studied words (true memory), older adults showed weaker activity than young adults in the hippocampus but stronger activity than young adults in the retrosplenial cortex. The hippocampal reduction is consistent with age-related deficits in recollection, whereas the retrosplenial increase suggests compensatory recruitment of alternative recollection-related regions. During incorrect recognition of critical lures (false memory), older adults displayed stronger activity than young adults in the left lateral temporal cortex, a region involved in semantic processing and semantic gist. Taken together, the results suggest that older adults’ deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated by the lateral temporal cortex. PMID:18303982

  13. Discovery of a monophagous true predator, a specialist termite-eating spider (Araneae: Ammoxenidae)

    PubMed Central

    Petráková, Lenka; Líznarová, Eva; Pekár, Stano; Haddad, Charles R.; Sentenská, Lenka; Symondson, William O. C.

    2015-01-01

    True predators are characterised by capturing a number of prey items during their lifetime and by being generalists. Some true predators are facultative specialists, but very few species are stenophagous specialists that catch only a few closely related prey types. A monophagous true predator that would exploit a single prey species has not been discovered yet. Representatives of the spider family Ammoxenidae have been reported to have evolved to only catch termites. Here we tested the hypothesis that Ammoxenus amphalodes is a monophagous termite-eater capturing only Hodotermes mossambicus. We studied the trophic niche of A. amphalodes by means of molecular analysis of the gut contents using Next Generation Sequencing. We investigated their willingness to accept alternative prey and observed their specific predatory behaviour and prey capture efficiency. We found all of the 1.4 million sequences were H. mossambicus. In the laboratory A. amphalodes did not accept any other prey, including other termite species. The spiders attacked the lateral side of the thorax of termites and immobilised them within 1 min. The paralysis efficiency was independent of predator:prey size ratio. The results strongly indicate that A. amphalodes is a monophagous prey specialist, specifically adapted to feed on H. mossambicus. PMID:26359085

  14. Management of true recurrent carpal tunnel syndrome: is it worthwhile to bring vascularized tissue?

    PubMed

    Duclos, L; Sokolow, C

    1998-01-01

    Since 1989, 13 consecutive cases of true recurrent carpal tunnel have been operated on. Average delay before reoperation was 20 months (3 to 60 months). Intraoperative findings were univocal: extensive fibrosis with nerve adhesion to the roof of the carpal tunnel and a lack of nerve gliding. Surgery performed was: extensive external neurolysis from distal forearm to distal to carpal tunnel to allow a complete freedom of the nerve. A vascularized flap was never performed. Mean follow-up was 27.5 months (range 4 to 74 months). Results were: complete relief of symptoms in 75%; improvement with complete disappearance of nocturnal symptoms but persistent dysesthesia in 17%; no improvement in one patient (Sudeck's dystrophy). Interests of this study are: homogeneous population (only true recurrence), no bias from work compensation, consecutive cases, one surgeon, standardized surgical procedure and one independent observer. Results suggest that main factor for true recurrent carpal tunnel syndrome is lack of normal gliding of the nerve and that an extensive neurolysis helps to restore this gliding.

  15. True temperature measurement on metallic surfaces using a two-color pyroreflectometer method.

    PubMed

    Hernandez, D; Netchaieff, A; Stein, A

    2009-09-01

    In the most common case of optical pyrometry, the major obstacle in determining the true temperature is the knowledge of the thermo-optical properties for in situ conditions. We present experimental results obtained with a method able to determine the true temperature of metallic surfaces above 500 degrees C when there is not parasitic effect by surrounding radiation. The method is called bicolor pyroreflectometry and it is based on Planck's law, Kirchhoff's law, and the assumption of identical reflectivity indicatrixes for the target surface at two different close wavelengths (here, 1.3 and 1.55 microm). The diffusion factor eta(d), the key parameter of the method, is introduced to determine the convergence temperature T(*), which is expected to be equal to the true temperature T. Our goal is to asses this method for different metallic surfaces. The validation of this method is made by comparison with thermocouples. Measurements were made for tungsten, copper, and aluminum samples of different roughnesses, determined by a rugosimeter. After introducing a theoretical model for two-color pyroreflectometry, we give a description of the experimental setup and present experimental applications of the subject method. The quality of the results demonstrates the usefulness of two-color pyroreflectometry to determine the temperatures of hot metals when the emissivity is not known and for the commercially important case of specular surfaces.

  16. True and false autobiographical memories in schizophrenia: preliminary results of a diary study.

    PubMed

    Pernot-Marino, Elodie; Schuster, Caroline; Hedelin, Guy; Berna, Fabrice; Zimmermann, Marie-Agathe; Danion, Jean-Marie

    2010-08-30

    The frequency of true and false autobiographical memories and associated states of conscious awareness, i.e., conscious recollection and simply knowing, as well as the respective roles of affective and cognitive processes in autobiographical memory construction, were assessed in eight patients with schizophrenia and eight control participants. A diary study methodology was used in combination with the Remember/Know procedure. The results showed a higher frequency of Know responses associated with the retrieval of both true and false memories in patients than in control participants. Whereas control participants rated higher at retrieval than at encoding the distinctiveness and personal importance of events, as well as the extent to which events furthered current personal plans, patients exhibited an opposite pattern of ratings, with ratings being lower at retrieval than at encoding. These preliminary results show a high frequency of simply knowing associated with the retrieval of true and false autobiographical memories in patients with schizophrenia and provide evidence for the interest of the diary study methodology for studying autobiographical memory in schizophrenia.

  17. How Fuzzy-Trace Theory Predicts True and False Memories for Words, Sentences, and Narratives

    PubMed Central

    Reyna, Valerie F.; Corbin, Jonathan C.; Weldon, Rebecca B.; Brainerd, Charles J.

    2016-01-01

    Fuzzy-trace theory posits independent verbatim and gist memory processes, a distinction that has implications for such applied topics as eyewitness testimony. This distinction between precise, literal verbatim memory and meaning-based, intuitive gist accounts for memory paradoxes including dissociations between true and false memory, false memories outlasting true memories, and developmental increases in false memory. We provide an overview of fuzzy-trace theory, and, using mathematical modeling, also present results demonstrating verbatim and gist memory in true and false recognition of narrative sentences and inferences. Results supported fuzzy-trace theory's dual-process view of memory: verbatim memory was relied on to reject meaning-consistent, but unpresented, sentences (via recollection rejection). However, verbatim memory was often not retrieved, and gist memory supported acceptance of these sentences (via similarity judgment and phantom recollection). Thus, mathematical models of words can be extended to explain memory for complex stimuli, such as narratives, the kind of memory interrogated in law. PMID:27042402

  18. Radiomic Texture Analysis Mapping Predicts Areas of True Functional MRI Activity

    PubMed Central

    Hassan, Islam; Kotrotsou, Aikaterini; Bakhtiari, Ali Shojaee; Thomas, Ginu A.; Weinberg, Jeffrey S.; Kumar, Ashok J.; Sawaya, Raymond; Luedi, Markus M.; Zinn, Pascal O.; Colen, Rivka R.

    2016-01-01

    Individual analysis of functional Magnetic Resonance Imaging (fMRI) scans requires user-adjustment of the statistical threshold in order to maximize true functional activity and eliminate false positives. In this study, we propose a novel technique that uses radiomic texture analysis (TA) features associated with heterogeneity to predict areas of true functional activity. Scans of 15 right-handed healthy volunteers were analyzed using SPM8. The resulting functional maps were thresholded to optimize visualization of language areas, resulting in 116 regions of interests (ROIs). A board-certified neuroradiologist classified different ROIs into Expected (E) and Non-Expected (NE) based on their anatomical locations. TA was performed using the mean Echo-Planner Imaging (EPI) volume, and 20 rotation-invariant texture features were obtained for each ROI. Using forward stepwise logistic regression, we built a predictive model that discriminated between E and NE areas of functional activity, with a cross-validation AUC and success rate of 79.84% and 80.19% respectively (specificity/sensitivity of 78.34%/82.61%). This study found that radiomic TA of fMRI scans may allow for determination of areas of true functional activity, and thus eliminate clinician bias. PMID:27151623

  19. Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes

    NASA Technical Reports Server (NTRS)

    Wu, H.; George, K.; Yang, T. C.

    1998-01-01

    PURPOSE: To study the frequency of true incomplete exchanges in radiation-induced chromosome aberrations. MATERIALS AND METHODS: Human lymphocytes were exposed to 2 Gy and 5 Gy of gamma-rays. Chromosome aberrations were studied using the fluorescence in situ hybridization (FISH) technique with whole chromosome-specific probes, together with human telomere probes. Chromosomes 2 and 4 were chosen in the present study. RESULTS: The percentage of incomplete exchanges was 27% when telomere signals were not considered. After excluding false incomplete exchanges identified by the telomere signals, the percentage of incomplete exchanges decreased to 11%. Since telomere signals appear on about 82% of the telomeres, the percentage of true incomplete exchanges should be even lower and was estimated to be 3%. This percentage was similar for chromosomes 2 and 4 and for doses of both 2 Gy and 5 Gy. CONCLUSIONS: The percentage of true incomplete exchanges is significantly lower in gamma-irradiated human lymphocytes than the frequencies reported in the literature.

  20. The True Cusp, a Unique Signature at Low- and Mid-Altitudes

    NASA Astrophysics Data System (ADS)

    Keith, W. R.; Winningham, J. D.; Parks, G. K.

    2001-12-01

    Recent observations have been made at low- and mid-altitudes of highly localized "true cusp" crossings made by the current DMSP F-series spacecraft and Cluster-II. These signatures are remarkably similar to the low-altitude measurements of DE-2, Astrid-2, UARS, and DMSP F-10 reported previously in Keith et. al. (2001). These new observations support the idea of a unique "true" or magnetic cusp that is a mapping of the magnetopause current layer to low altitudes. This is consistent with a narrow, wedge-shaped cusp that follows from antiparallel merging (Crooker, 1988). Mid- and exterior cusp data from the set of Cluster-II spacecraft show that this feature remains coherent out to several Re, greatly expanding the region available for the study of these signatures. Keith, W. R., J. D. Winningham and O. Norberg, A New, Unique Signature of the True Cusp, Ann. Geophys., V. 19, 611, June, 2001. Crooker, N. U., Mapping the Merging Potential From the Magnetopause to the Ionosphere Through the Dayside Cusp, J. Geophys. Res., V. 93, 7,338, 1988. >http://cluster.space.swri.edu/~waynek/agu.html

  1. Methods for obtaining true particle size distributions from cross section measurements

    SciTech Connect

    Lord, Kristina Alyse

    2013-01-01

    Sectioning methods are frequently used to measure grain sizes in materials. These methods do not provide accurate grain sizes for two reasons. First, the sizes of features observed on random sections are always smaller than the true sizes of solid spherical shaped objects, as noted by Wicksell [1]. This is the case because the section very rarely passes through the center of solid spherical shaped objects randomly dispersed throughout a material. The sizes of features observed on random sections are inversely related to the distance of the center of the solid object from the section [1]. Second, on a plane section through the solid material, larger sized features are more frequently observed than smaller ones due to the larger probability for a section to come into contact with the larger sized portion of the spheres than the smaller sized portion. As a result, it is necessary to find a method that takes into account these reasons for inaccurate particle size measurements, while providing a correction factor for accurately determining true particle size measurements. I present a method for deducing true grain size distributions from those determined from specimen cross sections, either by measurement of equivalent grain diameters or linear intercepts.

  2. Hiding true emotions: micro-expressions in eyes retrospectively concealed by mouth movements

    PubMed Central

    Iwasaki, Miho; Noguchi, Yasuki

    2016-01-01

    When we encounter someone we dislike, we may momentarily display a reflexive disgust expression, only to follow-up with a forced smile and greeting. Our daily lives are replete with a mixture of true and fake expressions. Nevertheless, are these fake expressions really effective at hiding our true emotions? Here we show that brief emotional changes in the eyes (micro-expressions, thought to reflect true emotions) can be successfully concealed by follow-up mouth movements (e.g. a smile). In the same manner as backward masking, mouth movements of a face inhibited conscious detection of all types of micro-expressions in that face, even when viewers paid full attention to the eye region. This masking works only in a backward direction, however, because no disrupting effect was observed when the mouth change preceded the eye change. These results provide scientific evidence for everyday behaviours like smiling to dissemble, and further clarify a major reason for the difficulty we face in discriminating genuine from fake emotional expressions. PMID:26915796

  3. From local adaptation to activism and global solidarity: framing a research and innovation agenda towards true health equity.

    PubMed

    Friedman, Eric A; Gostin, Lawrence O

    2017-02-21

    The proposal for a global health treaty aimed at health equity, the Framework Convention on Global Health, raises the fundamental question of whether we can achieve true health equity, globally and domestically, and if not, how close we can come. Considerable knowledge currently exists about the measures required to, at the least, greatly improve health equity. Why, then, do immense inequities remain? Building on this basic question, we propose four areas that could help drive the health equity research and innovation agenda over the coming years.First, recognizing that local contexts will often affect the success of policies aimed at health equity, local research will be critical to adapt strategies to particular settings. This part of the research agenda would be well-served by directly engaging intended beneficiaries for their insights, including through participatory action research, where the research contributes to action towards greater health equity.Second, even with the need for more local knowledge, why is the copious knowledge on how to reduce inequities not more frequently acted upon? What are the best strategies to close policymakers' knowledge gaps and to generate the political will to apply existing knowledge about improving health equity, developing the policies and devoting the resources required? Linked to this is the need to continue to build our understanding of how to empower the activism that can reshape power dynamics.Today's unequal power dynamics contribute significantly to disparities in a third area of focus, the social determinants of health, which are the primary drivers of today's health inequities. Continuing to improve our understanding of the pathways through which they operate can help in developing strategies to change these determinants and disrupt harmful pathways.And fourth, we return to the motivating question of whether we can achieve health equity. For example, can all countries have universal health coverage that

  4. Washington State's Student Achievement Initiative

    ERIC Educational Resources Information Center

    Pettitt, Maureen; Prince, David

    2010-01-01

    This article describes Washington State's Student Achievement Initiative, an accountability system implemented in 2005-06 that measures students' gains in college readiness, college credits earned, and degree or certificate completion. The goal of the initiative is to increase educational attainment by focusing on the critical momentum points…

  5. Meeting a Math Achievement Crisis

    ERIC Educational Resources Information Center

    Jennings, Lenora; Likis, Lori

    2005-01-01

    An urban community spotlighted declining mathematics achievement and took some measures, in which the students' performance increased substantially. The Benjamin Banneker Charter Public School in Cambridge, Massachusetts, engaged the entire community and launched the campaign called "Math Everywhere", which changed Benjamin Banneker's…

  6. Socioeconomic Determinants of Academic Achievement

    ERIC Educational Resources Information Center

    Tomul, Ekber; Savasci, Havva Sebile

    2012-01-01

    This study aims to investigate the relationship between academic achievement and the socioeconomic characteristics of elementary school 7th grade students in Burdur. The population of the study are 7th grade students who had education at elementary schools in Burdur in the 2007-2008 academic year. Two staged sampling was chosen as suitable for the…

  7. Goal Setting to Achieve Results

    ERIC Educational Resources Information Center

    Newman, Rich

    2012-01-01

    Both districts and individual schools have a very clear set of goals and skills for their students to achieve and master. In fact, except in rare cases, districts and schools develop very detailed goals they wish to pursue. In most cases, unfortunately, only the teachers and staff at a particular school or district-level office are aware of the…

  8. School Districts and Student Achievement

    ERIC Educational Resources Information Center

    Chingos, Matthew M.; Whitehurst, Grover J.; Gallaher, Michael R.

    2015-01-01

    School districts are a focus of education reform efforts in the United States, but there is very little existing research about how important they are to student achievement. We fill this gap in the literature using 10 years of student-level, statewide data on fourth- and fifth-grade students in Florida and North Carolina. A variance decomposition…

  9. Student Achievement, 1986-87.

    ERIC Educational Resources Information Center

    Mangino, Evangelina

    This report summarizes results of student achievement in the Austin (Texas) Independent School District (AISD) on the Texas Educational Assessment of Minimum Skills (TEAMS) tests in 1986-87. Major findings indicate the following: (1) 99.4% of AISD seniors to graduate in May 1987 passed the Exit-Level TEAMS tests, with only 17 denied diplomas in…

  10. Sociocultural Variation in Literacy Achievement

    ERIC Educational Resources Information Center

    Verhoeven, Ludo

    2006-01-01

    The purpose of this study was to describe the variations in literacy achievement among native and non-native upper primary school children (grades three to six) in the Netherlands. Various measures of word decoding, reading literacy and writing skill were collected from 1091 native Dutch children, 753 children with a former Dutch colonial…

  11. Game Addiction and Academic Achievement

    ERIC Educational Resources Information Center

    Sahin, Mehmet; Gumus, Yusuf Yasin; Dincel, Sezen

    2016-01-01

    The primary aim of this study was to investigate the correlation between game addiction and academic achievement. The secondary aim was to adapt a self-report instrument to measure game addiction. Three hundred and seventy high school students participated in this study. Data were collected via an online questionnaire that included a brief…

  12. The Widening Income Achievement Gap

    ERIC Educational Resources Information Center

    Reardon, Sean F.

    2013-01-01

    Has the academic achievement gap between high-income and low-income students changed over the last few decades? If so, why? And what can schools do about it? Researcher Sean F. Reardon conducted a comprehensive analysis of research to answer these questions and came up with some striking findings. In this article, he shows that income-related…

  13. Attribution Theory in Science Achievement

    ERIC Educational Resources Information Center

    Craig, Martin

    2013-01-01

    Recent research reveals consistent lags in American students' science achievement scores. Not only are the scores lower in the United States compared to other developed nations, but even within the United States, too many students are well below science proficiency scores for their grade levels. The current research addresses this problem by…

  14. Grouping Students for Increased Achievements.

    ERIC Educational Resources Information Center

    Holloway, John H.

    2001-01-01

    Reviews results of four recent studies exploring the effects of various student-grouping schemes on academic achievement. Grouping plans included multiage classrooms, full-time ability grouping, and within-classroom grouping. Two studies investigated administrator attitudes toward student grouping. Several studies found that grouping plans…

  15. Achievement, Hedonism and the Teacher.

    ERIC Educational Resources Information Center

    Ryan, Kevin

    1991-01-01

    The problem of poor school achievement is in part because students lack work and discipline values. The article suggests moral and ethical teachings inspire students to be better scholars and people; and teacher education must prepare teachers to be moral educators by reintroducing moral education into the curriculum. (SM)

  16. School Desegregation and Black Achievement.

    ERIC Educational Resources Information Center

    Cook, Thomas; And Others

    Seven papers commissioned by the National Institute of Education in order to clarify the state of recent knowledge about the effects of school desegregation on the academic achievement of black students are contained in this report. The papers, which analyze 19 "core" empirical studies on this topic, include: (1) "What Have Black Children Gained…

  17. Institutional Climate and Minority Achievement.

    ERIC Educational Resources Information Center

    Richardson, Richard C.

    This paper discusses ways that institutions can change the higher education system and environment to accommodate more minority students. The first section, "Institutional Climate and Minority Achievement," presents an overview of the problems facing colleges and universities with respect to recruiting and retaining minority students. In the…

  18. Faculty Development: Assessing Learner Achievement.

    ERIC Educational Resources Information Center

    Frey, Barbara A.; Overfield, Karen

    This study addressed the challenges of developing a faculty professional development workshop on assessment, measurement, and evaluation of achievement in adult learners. The setting for the workshop was a system of postsecondary career colleges throughout the United States. The curriculum development model of D. Kirkpatrick (1994) was used as a…

  19. Can Judges Improve Academic Achievement?

    ERIC Educational Resources Information Center

    Greene, Jay P.; Trivitt, Julie R.

    2008-01-01

    Over the last 3 decades student achievement has remained essentially unchanged in the United States, but not for a lack of spending. Over the same period a myriad of education reforms have been suggested and per-pupil spending has more than doubled. Since the 1990s the education reform attempts have frequently included judicial decisions to revise…

  20. Achieving a sustainable service advantage.

    PubMed

    Coyne, K P

    1993-01-01

    Many managers believe that superior service should play little or no role in competitive strategy; they maintain that service innovations are inherently copiable. However, the author states that this view is too narrow. For a company to achieve a lasting service advantage, it must base a new service on a capability gap that competitors cannot or will not copy.