Science.gov

Sample records for aci materials journal

  1. Controlled low strength materials (CLSM), reported by ACI Committee 229

    SciTech Connect

    Rajendran, N.

    1997-07-01

    Controlled low-strength material (CLSM) is a self-compacted, cementitious material used primarily as a backfill in lieu of compacted fill. Many terms are currently used to describe this material including flowable fill, unshrinkable fill, controlled density fill, flowable mortar, flowable fly ash, fly ash slurry, plastic soil-cement, soil-cement slurry, K-Krete and other various names. This report contains information on applications, material properties, mix proportioning, construction and quality-control procedures. This report`s intent is to provide basic information on CLSM technology, with emphasis on CLSM material characteristics and advantages over conventional compacted fill. Applications include backfills, structural fills, insulating and isolation fills, pavement bases, conduit bedding, erosion control, void filling, and radioactive waste management.

  2. SNL-ptc2acis

    SciTech Connect

    Ames, Arlo L.; Kholwadwala, Deepesh

    2002-07-15

    SNL-ptc2acis translates Pro/Engineer descriptions of parts, assemblies, and cross-sections to ACIS representation. It is developed using Pro/Toolkit and the ACIS kernel. As such, it requires a Pro/Engineer license in order to execute, but is not subject to the issues of file encryption as a direct file reader would be.

  3. ACI and MACI.

    PubMed

    Kon, Elizaveta; Filardo, Giuseppe; Di Martino, Alessandro; Marcacci, Maurilio

    2012-03-01

    Regenerative procedures aim to recreate a hyaline-like tissue, thus restoring a biologically and biomechanically valid articular surface with durable clinical results. Autologous chondrocyte implantation (ACI) has been developed two decades ago, and both the production of a hyaline-like articular surface and a satisfactory clinical outcome have been documented at medium-long follow-up. Bioengineering technology further improved this regenerative treatment approach to include matrix-assisted ACI (MACI) techniques. These procedures have been introduced in the clinical practice one decade ago, showing similar results while at the same time overcoming most of the concerns related to the first-generation ACI. The use of scaffolds to create a cartilage-like tissue in a three-dimensional culture system allows for the optimization of the procedure from both the biological and surgical point of view. However, despite thousands of treated patients and many published studies suggesting good clinical results and durability of these procedures, the properties of healthy, normal articular cartilage are still unmatched by any available substitute. Both indications and results of these substitutes are still controversial. The role of many variables that may influence the final outcome still need to be clarified to further improve the potential benefits of these biological regenerative procedures.

  4. ACIS Door Failure Investigation and Mitigation Procedures

    NASA Technical Reports Server (NTRS)

    Podgorski, William A.; Tice, Neil W.; Plucinsky, Paul P.

    2000-01-01

    NASA's Chandra X-ray Observatory (formerly AXAF) was launched on July 23, 1999 and is currently in orbit performing scientific studies. Chandra is the third of NASA's Great Observatories to be launched, following the Hubble Space Telescope and the Compton Gamma Ray Observatory. One of four primary science instruments on Chandra, and one of only two focal plane instruments, is the Advanced CCD Imaging Spectrometer, or ACIS. The ACIS focal plane and Optical Blocking Filter (OBF) must be launched under vacuum, so a tightly sealed, functioning door and venting subsystem were implemented. The door was opened two and one-half weeks after launch (after most out-gassing of composite materials) and allowed X-rays to be imaged by the ACIS CCD's in the focal plane. A failure of this door to open on-orbit would have eliminated all ACIS capabilities, severely degrading mission science. During the final pre-flight thermal-vacuum test of the fully integrated Chandra Observatory at TRW, the ACIS door failed to open when commanded to do so. This paper describes the efforts, under considerable time pressure, by NASA, its contractors and outside review teams to investigate the failure and to develop modified hardware and procedures which would correct the problem. Of interest is the fact that the root cause of the test failure was never clearly identified despite massive effort. We ultimately focussed on hardware and procedures designed to mitigate the effects of potential, but unproven, failure modes. We describe a frequent real-world engineering situation in which one must proceed on the best basis possible in the absence of the complete set of facts.

  5. Journaling.

    ERIC Educational Resources Information Center

    Barlow, Bob

    2001-01-01

    Daily journal writing can help students become strong, confident writers. Students can use journals to reflect on what they are studying, brainstorm on a topic before writing an essay, track and react to current events, and explore ideas in their imaginations. Tips for journal writing include: keep it stress free, reassure students they are…

  6. Top reviewers for the Journal of Nuclear Materials 2016

    NASA Astrophysics Data System (ADS)

    Was, Gary

    2017-01-01

    The Journal of Nuclear Materials achieves its scientific excellence through several familiar editorial activities. Manuscripts are submitted by authors describing their research methods and results, a constructive refereeing process is generously provided by peer reviewers, and the many steps and decisions of the editorial process are carried out by the Editors with assistance from the Advisory Editorial Board. With the exception of peer reviewers, the names of the people within these groups are published in the pages of the Journal. Thereby they receive recognition in the community for their work. However, all of us Journal constituents owe a large debt of gratitude to reviewers. They dedicate time, energy and remarkable depth of expertise to evaluate submitted manuscripts. As a result of their work most manuscripts are substantively improved. We also recognize the fact that many times the underlying research itself is advanced by the recommendations of our reviewers. Because the Journal maintains a strict policy of anonymous peer review, we do not make known the names of reviewers in association with particular manuscripts. Within this constraint the Editors and Publisher wish to find ways to recognize our reviewers. We recently instituted a top reviewer honor for a single individual, awarded at the NuMat conference (http://www.nuclearmaterialsconference.com).

  7. [Cartilage biopsy for autologous chondrocyte implantation (ACI)].

    PubMed

    Pestka, J M; Salzmann, G M; Südkamp, N P; Niemeyer, P

    2013-06-01

    Autologous chondrocyte implantation (ACI) is an established two-step procedure for the treatment of full-thickness cartilage defects of the knee. Cartilage harvest from the affected knee joint represents the first step of this procedure and is essential for further in vitro expansion of autologous chondrocytes. Nevertheless, the cartilage biopsy process itself is underrepresented in the scientific literature and currently there is only a limited amount of data available addressing this process. Biopsy location as well as the technique itself and instruments used for cartilage collection are not well defined and only little standardisation can be found. The article describes the relevant aspects of the biopsy in the context of ACI with regard to the literature available. Follow-up studies to better define and standardise the cartilage biopsy process are thus required.

  8. ACIS Extract takes on the Carina Complex

    NASA Astrophysics Data System (ADS)

    Broos, Patrick

    2009-09-01

    The Chandra community has been using the ACIS Extract (AE) software package to extract and analyze sources in ACIS observations since y2002. AE brings significant automation to the extraction of point-like and diffuse sources, and provides a simple analysis strategy for projects that involve multiple overlapping observations. The community has in past years applied AE to some very complex Chandra projects, e.g. the Chandra Deep Field and the Galactic Center. The AE developers have recently completed their first AE analysis of similar scale---the 14,000 point sources and extensive diffuse emission in the Carina Very Large Project. That experience has significantly refined AE's capabilities and recipes; we will illustrate some of this new functionality with examples from Carina.

  9. Trends in the Use of Supplementary Materials in Environmental Science Journals

    ERIC Educational Resources Information Center

    Kenyon, Jeremy; Sprague, Nancy R.

    2014-01-01

    Our research examined the use of supplementary materials in six environmental science disciplines: atmospheric sciences, biology, fisheries, forestry, geology, and plant sciences. Ten key journals were selected from each of these disciplines and the number of supplementary materials, such as data files or videos, in each issue was noted over a…

  10. Introduction to Special Edition (of the Journal of Nuclear Materials Management) on Reducing the Threat from Radioactive Materials

    SciTech Connect

    Mladineo, Stephen V.

    2007-03-01

    Introductory article for special edition of the JOURNAL OF NUCLEAR MATERIALS MANAGEMENT outlining the Institute of Nuclear Materials Management Nonproliferation and Arms Control Technical Division. In particular the International Nuclear and Radiological Security Standing Committee and its initial focus covering four topical areas--Radiological Threat Reduction, Nuclear Smuggling and Illicit Trafficking, Countering Nuclear Terrorism, and Radioligical Terrorism Consequence Management.

  11. “Terms and conditions of use” for journal articles and scholarly journals : A survey on the licensing processes associated with electronic scholarly materials

    NASA Astrophysics Data System (ADS)

    Hidaka, Masako

    Copyright policies and terms directly affect the approach taken by journal editors, authors and readers regarding dealing with of articles and/or copyrighted materials. However Japanese academic society publishers have some trouble in licensing processes for copyrighted materials as previous studies pointed out. In 2011 we conducted a survey on “terms and conditions of use” of electronic journal and the licensing practices associated with electronic scholarly materials. The survey showed commercial publishers have enough announcements on reuse of copyrighted materials for readers. On the other hand Japanese academic societies' cares for readers tend to not enough. They publish journals both in Japanese and in English. Subsequently, English and Japanese templates of “terms and conditions of use” for Japanese academic society publishers were proposed. The templates were developed based on an understanding of the International Association of Scientific, Technical and Medical Publishers' “STM Permissions Guidelines,” which were designed to establish a standard and reasonable approach to granting permission for republication to all signatory publishers.The survey showed that Japanese academic society publishers and commercial publishers are facing the same issues regarding acceptable use of electronic supplemental materials for journal articles. This issue remains to be solved.

  12. Phylogenetic ecology of the freshwater Actinobacteria acI lineage.

    PubMed

    Newton, Ryan J; Jones, Stuart E; Helmus, Matthew R; McMahon, Katherine D

    2007-11-01

    The acI lineage of freshwater Actinobacteria is a cosmopolitan and often numerically dominant member of lake bacterial communities. We conducted a survey of acI 16S rRNA genes and 16S-23S rRNA internal transcribed spacer regions from 18 Wisconsin lakes and used standard nonphylogenetic and phylogenetic statistical approaches to investigate the factors that determine acI community composition at the local scale (within lakes) and at the regional scale (across lakes). Phylogenetic reconstruction of 434 acI 16S rRNA genes revealed a well-defined and highly resolved phylogeny. Eleven previously unrecognized monophyletic clades, each with > or =97.9% within-clade 16S rRNA gene sequence identity, were identified. Clade community similarity positively correlated with lake environmental similarity but not with geographic distance, implying that the lakes represent a single biotic region containing environmental filters for communities that have similar compositions. Phylogenetically disparate clades within the acI lineage were most abundant at the regional scale, and local communities were comprised of more closely related clades. Lake pH was a strong predictor of the community composition, but only when lakes with a pH below 6 were included in the data set. In the remaining lakes (pH above 6) biogeographic patterns in the landscape were instead a predictor of the observed acI community structure. The nonrandom distribution of the newly defined acI clades suggests potential ecophysiological differences between the clades, with acI clades AI, BII, and BIII preferring acidic lakes and acI clades AII, AVI, and BI preferring more alkaline lakes.

  13. INNOVATIONS IN THE ANALYSIS OF CHANDRA-ACIS OBSERVATIONS

    SciTech Connect

    Broos, Patrick S.; Townsley, Leisa K.; Feigelson, Eric D.; Getman, Konstantin V.; Garmire, Gordon P.; Bauer, Franz E.

    2010-05-10

    As members of the instrument team for the Advanced CCD Imaging Spectrometer (ACIS) on NASA's Chandra X-ray Observatory and as Chandra General Observers, we have developed a wide variety of data analysis methods that we believe are useful to the Chandra community, and have constructed a significant body of publicly available software (the ACIS Extract package) addressing important ACIS data and science analysis tasks. This paper seeks to describe these data analysis methods for two purposes: to document the data analysis work performed in our own science projects and to help other ACIS observers judge whether these methods may be useful in their own projects (regardless of what tools and procedures they choose to implement those methods). The ACIS data analysis recommendations we offer here address much of the workflow in a typical ACIS project, including data preparation, point source detection via both wavelet decomposition and image reconstruction, masking point sources, identification of diffuse structures, event extraction for both point and diffuse sources, merging extractions from multiple observations, nonparametric broadband photometry, analysis of low-count spectra, and automation of these tasks. Many of the innovations presented here arise from several, often interwoven, complications that are found in many Chandra projects: large numbers of point sources (hundreds to several thousand), faint point sources, misaligned multiple observations of an astronomical field, point source crowding, and scientifically relevant diffuse emission.

  14. Supplemental Journal Article Materials: A progress report on an information industry initiative

    NASA Astrophysics Data System (ADS)

    Schwarzman, A. B.

    2011-12-01

    Who could possibly quibble with the idea of publishing supplemental materials to a journal article? Making them available makes it possible for the Earth and space scientists to demonstrate supporting evidence, such as multimedia, computer programs, and datasets; gives the authors the opportunity to present in-depth studies that would not otherwise be available; and enables the readers to replicate experiments and verify their results. However, the scholarly publishing ecosystem is now being threatened by a veritable tsunami of supplemental materials that have to be peer reviewed, identified, described, and made discoverable and citeable; such materials also have to be archived, preserved, and perpetually converted to the contemporary formats to be available to a future researcher. Moreover, the readers often have no clear indication of how critical a particular supplemental material is to the scientific conclusions of the article and thus are not sure whether they should spend their time reading/viewing/running it. In some cases it is not even clear what the material actually supplements. While one segment of the research community argues that even more supplemental materials should be made available, another segment increasingly voices its concern stating categorically that a research article is not a data dump or an FTP site. From the publisher's perspective, dealing with supplemental materials in a responsible fashion is becoming an increasingly costly proposition. Faced with formidable challenges of managing supplemental materials, the information profession community in 2010 formed a joint NISO/NFAIS Working Group to develop Recommended Practices for curating supplemental materials during their life cycle, including but not limited to their selection, peer review, editing, production, presentation, providing context, identification, linking, citing, hosting, discovery, metadata and markup, packaging, accessibility, and preservation. The Recommended Practices

  15. Successful enrichment of the ubiquitous freshwater acI Actinobacteria.

    PubMed

    Garcia, Sarahi L; McMahon, Katherine D; Grossart, Hans-Peter; Warnecke, Falk

    2014-02-01

    Actinobacteria of the acI lineage are often the numerically dominant bacterial phylum in surface freshwaters, where they can account for > 50% of total bacteria. Despite their abundance, there are no described isolates. In an effort to obtain enrichment of these ubiquitous freshwater Actinobacteria, diluted freshwater samples from Lake Grosse Fuchskuhle, Germany, were incubated in 96-well culture plates. With this method, a successful enrichment containing high abundances of a member of the lineage acI was established. Phylogenetic classification showed that the acI Actinobacteria of the enrichment belonged to the acI-B2 tribe, which seems to prefer acidic lakes. This enrichment grows to low cell densities and thus the oligotrophic nature of acI-B2 was confirmed.

  16. Swift observations of Gaia17acy/2017it

    NASA Astrophysics Data System (ADS)

    Sokolovsky, K.; Wyrzykowski, L.; Hamanowicz, A.; Gromadzki, M.

    2017-01-01

    The optical transient Gaia17acy was discovered on 2017-01-14 coinciding with an uncataloged galaxy. Follow-up spectroscopic observations by NOT (ATel #9990) and PESSTO (ATel #10012) show blue continuum and emission lines at z = 0.175.

  17. ACIS design compliance with principle accelerator safety interlock design requirements.

    SciTech Connect

    Knott, M.

    2005-02-23

    Prior to and during the design of the APS's Access Control Interlock System (ACIS), an effort was made to insure that the design complied with the relevant DOE and ANL requirements as well as those set forth in other recognized documents then in circulation. A paragraph-by-paragraph listing of the requirements (in some cases, recommended practices) and the corresponding ACIS design features was compiled for use by the review committees then in place. This tabulation was incorporated in the APS Safety Analysis Document (SAD) as Appendix A. With the evolutionary changes that have occurred to the APS and to the documents referenced, some of the details of these compliances have evolved as well. It has been decided to maintain the SAD as a ''living'' document, editing it in close time proximity to the evolving APS. Since Appendix A depicted the ACIS's original design compliance to an also-evolving set of documents, it was decided to remove Appendix A but to retain it as a reference document. This LS Note now contains that set of original design compliances. As the APS and the ACIS continue to evolve, the changes made will be subject to internal review and approval and will always be subject to the requirements set forth by the DOE and ANL.

  18. Spin trapping of nitric oxide by aci anions of nitroalkanes.

    PubMed

    Reszka, Krzysztof J; Bilski, Piotr; Chignell, Colin F

    2004-03-01

    In alkaline solutions, nitroalkanes (RCH2NO2) undergo deprotonation and rearrange to an aci anion (RHC=NO2-), which may function as a spin trap. Using electron paramagnetic resonance (EPR) spectroscopy, we have investigated suitability of aci anions of a series of nitroalkanes (CH3NO2, CH3CH2NO2, CH3(CH2)2NO2, and CH3(CH2)3NO2) to spin trap nitric oxide (*NO). Based on the observed EPR spectra, the general structure of the adducts, formed by addition of *NO to RHC=NO2-, was identified as nitronitroso dianion radicals of general formula [RC(NO)NO2]*2- in strong base (0.5 M NaOH), and as a mono-anion radical [RCH(NO)NO2]*- in alkaline buffers, pH 10-13. The hyperfine splitting on 14N in the -NO2 moiety (11.2-12.48 G) is distinctly different from the splitting on 14N in the -NO moiety of the adducts (5.23-6.5 G). The structure of the adducts was verified using 15N-labeled *NO, which produced radicals, in which triplet due to splitting on 14N (I = 1) in 14NO/aci nitro adducts was replaced by a doublet due to 15N (I = 1/2) in 15NO/aci nitro adducts. EPR spectra of aci nitromethane/NO adduct recorded in NaOH and NaOD (0.5 M) showed that the hydrogen at alpha-carbon can be exchanged for deuterium, consistent with structures of the adducts being [CH(NO)NO2]*2- and [CD(NO)NO2]*2-, respectively. These results indicate that nitroalkanes could potentially be used as prototypes for development of *NO-specific spin traps suitable for EPR analysis.

  19. The ACI-REF Program: Empowering Prospective Computational Researchers

    NASA Astrophysics Data System (ADS)

    Cuma, M.; Cardoen, W.; Collier, G.; Freeman, R. M., Jr.; Kitzmiller, A.; Michael, L.; Nomura, K. I.; Orendt, A.; Tanner, L.

    2014-12-01

    The ACI-REF program, Advanced Cyberinfrastructure - Research and Education Facilitation, represents a consortium of academic institutions seeking to further advance the capabilities of their respective campus research communities through an extension of the personal connections and educational activities that underlie the unique and often specialized cyberinfrastructure at each institution. This consortium currently includes Clemson University, Harvard University, University of Hawai'i, University of Southern California, University of Utah, and University of Wisconsin. Working together in a coordinated effort, the consortium is dedicated to the adoption of models and strategies which leverage the expertise and experience of its members with a goal of maximizing the impact of each institution's investment in research computing. The ACI-REFs (facilitators) are tasked with making connections and building bridges between the local campus researchers and the many different providers of campus, commercial, and national computing resources. Through these bridges, ACI-REFs assist researchers from all disciplines in understanding their computing and data needs and in mapping these needs to existing capabilities or providing assistance with development of these capabilities. From the Earth sciences perspective, we will give examples of how this assistance improved methods and workflows in geophysics, geography and atmospheric sciences. We anticipate that this effort will expand the number of researchers who become self-sufficient users of advanced computing resources, allowing them to focus on making research discoveries in a more timely and efficient manner.

  20. Experimental Evaluation of Journal Bearing Stability and New Gas Bearing Material

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Dimofte, Florin

    2001-01-01

    It has been estimated that the noise levels in aircraft engine transmissions can be reduced by as much as 10 dB through the use of journal bearings. The potential benefits of lower noise levels include reduced wear, longer gear life and enhanced comfort for passengers and crew. Based on this concept the journal-thrust wave bearing was analyzed and its performance was evaluated. Numerical codes, developed over the past 30 years by Dr. Dimofte, were used to predict the performance of the bearing. The wave bearing is a fluid film bearing and therefore was analyzed using the Reynolds pressure equation. The formulation includes turbulent flow concepts and possesses a viscosity-temperature correction. The centrifugal growth of the bearing diameter and the deformation of the bearing under gear loads were also incorporated into the code. An experimental rig was developed to test the journal-thrust wave bearing.

  1. Experimental Evaluation of Journal Bearing Stability and New Gas Wave Bearing Materials

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Dimofte, Florin

    1998-01-01

    A gas journal bearing, with a wavy surfaces was tested in a range of speeds up to 18,000 RPM to determine its stability in an unloaded condition as a function of the wave amplitude. The bearing, was 50 mm in diameter, 58 mm long and had 0.01 65 mm radial clearance. Three waves were created on the inner surface by deforming the bearing sleeve. The ratio of the wave amplitude to the radial clearance (the wave amplitude ratio) was varied from zero to 0.3.

  2. Mutations in ACY1, the Gene Encoding Aminoacylase 1, Cause a Novel Inborn Error of Metabolism

    PubMed Central

    Sass, Jörn Oliver; Mohr, Verena; Olbrich, Heike; Engelke, Udo; Horvath, Judit; Fliegauf, Manfred; Loges, Niki Tomas; Schweitzer-Krantz, Susanne; Moebus, Ralf; Weiler, Polly; Kispert, Andreas; Superti-Furga, Andrea; Wevers, Ron A.; Omran, Heymut

    2006-01-01

    N-terminal acetylation of proteins is a widespread and highly conserved process. Aminoacylase 1 (ACY1; EC 3.5.14) is the most abundant of the aminoacylases, a class of enzymes involved in hydrolysis of N-acetylated proteins. Here, we present four children with genetic deficiency of ACY1. They were identified through organic acid analyses using gas chromatography–mass spectrometry, revealing increased urinary excretion of several N-acetylated amino acids, including the derivatives of methionine, glutamic acid, alanine, leucine, glycine, valine, and isoleucine. Nuclear magnetic resonance spectroscopy analysis of urine samples detected a distinct pattern of N-acetylated metabolites, consistent with ACY1 dysfunction. Functional analyses of patients’ lymphoblasts demonstrated ACY1 deficiency. Mutation analysis uncovered recessive loss-of-function or missense ACY1 mutations in all four individuals affected. We conclude that ACY1 mutations in these children led to functional ACY1 deficiency and excretion of N-acetylated amino acids. Questions remain, however, as to the clinical significance of ACY1 deficiency. The ACY1-deficient individuals were ascertained through urine metabolic screening because of unspecific psychomotor delay (one subject), psychomotor delay with atrophy of the vermis and syringomyelia (one subject), marked muscular hypotonia (one subject), and follow-up for early treated biotinidase deficiency and normal clinical findings (one subject). Because ACY1 is evolutionarily conserved in fish, frog, mouse, and human and is expressed in the central nervous system (CNS) in human, a role in CNS function or development is conceivable but has yet to be demonstrated. Thus, at this point, we cannot state whether ACY1 deficiency has pathogenic significance with pleiotropic clinical expression or is simply a biochemical variant. Awareness of this new genetic entity may help both in delineating its clinical significance and in avoiding erroneous diagnoses. PMID

  3. Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats.

    PubMed

    Blank, Edward W; Wong, Po-Yin; Lakshmanaswamy, Rajkumar; Guzman, Raphael; Nandi, Satyabrata

    2008-03-04

    August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammary cancers in ovary-intact ACI rats. To determine the role of progesterone in mammary carcinogenesis, six-week-old intact and ovariectomized ACI rats were continuously exposed to low- and high-dose estrogen alone, progesterone alone, low-dose estrogen plus progesterone, and ovariectomized ACI rats with high-dose estrogen plus progesterone. Also, ovariectomized ACI rats were treated with high-dose estrogen plus progesterone plus testosterone to determine the role of the androgen, testosterone, if any, in hormonal mammary carcinogenesis. The results indicate that continuous exposure to high, but not low, concentrations of estrogen alone can induce mammary carcinogenesis in intact but not in ovariectomized rats. Mammary carcinogenesis in ovariectomized ACI rats requires continuous exposure to high concentrations of estrogen and progesterone. The addition of testosterone propionate does not affect tumor incidence in such rats. These results suggest that both ovarian hormones estrogen and progesterone are necessary for mammary carcinogenesis induced solely by hormones in ovariectomized ACI rats. Our results are in agreement with the Women's Health Initiative studies, where treatment of postmenopausal women with estrogen (ERT) alone did not increase the risk of breast cancer, but estrogen and progesterone (HRT) did.

  4. Phylogenetic Ecology of the Freshwater Actinobacteria acI Lineage▿ †

    PubMed Central

    Newton, Ryan J.; Jones, Stuart E.; Helmus, Matthew R.; McMahon, Katherine D.

    2007-01-01

    The acI lineage of freshwater Actinobacteria is a cosmopolitan and often numerically dominant member of lake bacterial communities. We conducted a survey of acI 16S rRNA genes and 16S-23S rRNA internal transcribed spacer regions from 18 Wisconsin lakes and used standard nonphylogenetic and phylogenetic statistical approaches to investigate the factors that determine acI community composition at the local scale (within lakes) and at the regional scale (across lakes). Phylogenetic reconstruction of 434 acI 16S rRNA genes revealed a well-defined and highly resolved phylogeny. Eleven previously unrecognized monophyletic clades, each with ≥97.9% within-clade 16S rRNA gene sequence identity, were identified. Clade community similarity positively correlated with lake environmental similarity but not with geographic distance, implying that the lakes represent a single biotic region containing environmental filters for communities that have similar compositions. Phylogenetically disparate clades within the acI lineage were most abundant at the regional scale, and local communities were comprised of more closely related clades. Lake pH was a strong predictor of the community composition, but only when lakes with a pH below 6 were included in the data set. In the remaining lakes (pH above 6) biogeographic patterns in the landscape were instead a predictor of the observed acI community structure. The nonrandom distribution of the newly defined acI clades suggests potential ecophysiological differences between the clades, with acI clades AI, BII, and BIII preferring acidic lakes and acI clades AII, AVI, and BI preferring more alkaline lakes. PMID:17827330

  5. Journal standards.

    PubMed

    Jackson, R

    2003-08-01

    Despite its many imperfections, the peer review process is a firmly established quality control system for scientific literature. It gives readers some assurance that the work and views that are reported meet standards that are acceptable to a journal. Maureen Revington's editorial in a recent issue of the Australian Veterinary Journal (Revington2002) gives a good concise warts and all overview of the process and is well worth reading. I have some concerns about several articles in the December 2002 issue of the New Zealand Veterinary Journal (Volume 50, Number 6), devoted to the health and welfare of farmed deer, that relate to extensive citing of non-peer reviewed papers. I can understand the need for information to flow from researchers to the wider community but that need is already satisfied by publications such as the proceedings of the Deer Branch of the New Zealand Veterinary Association and Proceedings of the New Zealand Society of Animal Production. Non-peer reviewed papers have been cited in the Journal in the past but never to the extent displayed in this particular issue. It degrades the peer-review process and creates an added burden for reviewers who are forced to grapple with the uncertainties of the science in non-peer reviewed citations. One of my fears is that this process allows science from non peer reviewed articles to be legitimised by its inclusion in a peer reviewed journal and perhaps go on to be accepted as dogma. This is a real danger given the difficulties associated with tracing back to original citations and the increasing volume of scientific literature. It also affords opportunities for agencies to pick up questionable and doubtful science and tout it as support for their products or particular points of view. If deer researchers choose to publish most of their work in proceedings then so be it. However this approach, which seems to becoming increasingly prevalent in the deer sector, is questionable from an established science point

  6. Chandra ACIS Observations of Jovian X-Ray Emission

    NASA Technical Reports Server (NTRS)

    Garmire, Gordon; Elsner, Ronald; Feigelson, Eric; Ford, Peter; Gladstone, G. Randall; Hurley, Kevin; Metzger, Albert; Waite, J. Hunter, Jr.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    On November 25 and 26, 1999, the Chandra X-ray spacecraft conducted a set of four 19,000 sec observations of Jupiter. The ACIS-S instrument configuration was used for its good low energy efficiency and spatial resolution. An anomalous response was obtained which was subsequently attributed to strong jovian infrared radiation penetrating the detector and piling up spurious events across the entire X-ray range. However, the pre-observation establishment of an offsetting bias field has allowed the recovery of data from that portion of Jupiter's disc which remained within the elevated portion of the bias field during the observation. This ranges from fewer than 3000 sec to the entire observing time for about 10% of the planet. Auroral emission is seen near both poles in each observation. The northern aurora ia overall more intense than the southern, consistent with prior Einstein and ROSAT Observatory results. The southern aurora shows more modulation with Jupiter's rotation than the northern. Spatial resolution has been improved by at least a factor of two over prior measurements but convincing evidence of structure has not been seen. Lower latitude emission, first observed by ROSAT, is confirmed with flux levels averaging more than a factor of five below peak auroral values. Pronounced variation in the observed emission has occurred over the observing period. The spectral response extends from 0.24 keV, below which noise dominates, to about 1.2 keV. For all four observations the spectrum is clearly enhanced between 0.45 and 0.85 keV. This is apparently unequivocal evidence that Jupiter's X-ray emission is the result of oxygen and perhaps sulfur ions precipitating into the planet's atmosphere, where they undergo charge exchange interactions. The identification of specific transitions lines in the spectrum is among the ongoing efforts. A bremsstrahlung component has not yet been identified.

  7. Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus

    PubMed Central

    Yang, Kunlong; Qin, Qiuping; Liu, Yinghang; Zhang, Limei; Liang, Linlin; Lan, Huahui; Chen, Chihao; You, Yunchao; Zhang, Feng; Wang, Shihua

    2016-01-01

    Aspergillus flavus is one of the most important opportunistic pathogens of crops and animals. The carcinogenic mycotoxin, aflatoxins produced by this pathogen cause a health problem to human and animals. Since cyclic AMP signaling controls a range of physiological processes, like fungal development and infection when responding to extracellular stimuli in fungal pathogens, in this study, we investigated the function of adenylate cyclase, a core component of cAMP signaling, in aflatoxins biosynthesis and virulence on plant seeds in A. flavus. A gene replacement strategy was used to generate the deletion mutant of acyA that encodes the adenylate cyclase. Severe defects in fungal growth, sporulation and sclerotia formation were observed in the acyA deletion mutant. The defect in radical growth could be partially rescued by exogenous cAMP analog. The acyA mutant was also significantly reduced in aflatoxins production and virulence. Similar to the former studies in other fungi, The acyA mutant showed enhancing tolerance to oxidative stress, but more sensitive to heat stress. Overall, the pleiotropic defects of the acyA deletion mutant indicates that the cAMP-PKA pathway is involved in fungal development, aflatoxins biosynthesis and plant seed invasion in A. flavus. PMID:28066725

  8. Aminoacylase I deficiency due to ACY1 mRNA exon skipping.

    PubMed

    Ferri, L; Funghini, S; Fioravanti, A; Biondi, E G; la Marca, G; Guerrini, R; Donati, M A; Morrone, A

    2014-10-01

    Aminoacylase 1 (ACY1) deficiency is a rare inborn error of metabolism of which less than 20 observations have been described. Patients exhibit urinary excretion of specific N-acetyl amino acids and manifest a heterogeneous clinical spectrum including intellectual disability, motor delay, seizures, moderate to severe mental retardation, absent speech, growth delay, muscular hypotonia and autistic features. Here, we report the case of ACY1 enzyme deficiency in a 6-year-old girl presenting severe intellectual disability, motor retardation, absence of spontaneous locomotor activity and severe speech delay. Urinary excretion of N-acetylated amino acids was present. Mutational analysis of ACY1 gene identified the new homozygous c.1001_1001+5del6 mutation, which alters the mRNA transcription leading to exon 13 skipping and inclusion of a premature stop codon (p.Lys308Glufs*7). A quantitative fluorescent multiplex-polymerase chain reaction (QFM-PCR) assay has been set up and confirmed homozygosity of the mutation in the patient's DNA. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts. The structure of the mutated protein has been defined by homology modeling (HM). Our data endorse the hypothesis of a link between this inborn error of metabolism and the neurological manifestations observed in patients with ACY1 deficiency.

  9. Using ACIS on the Chandra X-ray Observatory as a Particle Radiation Monitor II

    NASA Technical Reports Server (NTRS)

    Grant, C. E.; Ford, P. G.; Bautz, M. W.; ODell, S. L.

    2012-01-01

    The Advanced CCD Imaging Spectrometer is an instrument on the Chandra X-ray Observatory. CCDs are vulnerable to radiation damage, particularly by soft protons in the radiation belts and solar storms. The Chandra team has implemented procedures to protect ACIS during high-radiation events including autonomous protection triggered by an on-board radiation monitor. Elevated temperatures have reduced the effectiveness of the on-board monitor. The ACIS team has developed an algorithm which uses data from the CCDs themselves to detect periods of high radiation and a flight software patch to apply this algorithm is currently active on-board the instrument. In this paper, we explore the ACIS response to particle radiation through comparisons to a number of external measures of the radiation environment. We hope to better understand the efficiency of the algorithm as a function of the flux and spectrum of the particles and the time-profile of the radiation event.

  10. New Journalism.

    ERIC Educational Resources Information Center

    Fishwick, Marshall, Ed.

    This volume contains a selection of articles which examine, critique, and help to define the phenomenon of new journalism. Included are "Popular Culture and the New Journalism" (Marshall Fishwick), "Entrance" (Richard A. Kallan), "How 'New'?" (George A. Hough III), "Journalistic Primitivism" (Everette E. Dennis), "Wherein Lies the Value?" (Michael…

  11. After Journalism.

    ERIC Educational Resources Information Center

    Jurgensen, Karen; Meyer, Philip

    1992-01-01

    Maintains that the central journalistic function is changing from the transportation of information to its processing. Offers a model for the more sophisticated standard of objectivity needed by the new process-intensive journalism. Discusses changes in journalism training to meet these demands. (SR)

  12. HRD Journals.

    ERIC Educational Resources Information Center

    1996

    This document consists of four papers presented during a symposium on human resource development (HRD) journals moderated by Peter W.J. Schramade at the 1996 conference of the Academy of Human Resource Development. "Refereed Journals: The Cornerstone of a Developing Profession" (Gary N. McLean) describes the purpose, format, success, and…

  13. 78 FR 66097 - Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor, Inc., New Generation Holdings, Inc., and Nuevo Financial Center, Inc.; Order of Suspension of Trading October 31, 2013. It appears to...

  14. Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor

    PubMed Central

    Tamang, David; Yang, Min; Jones, Simon S.; Quayle, Steven N.

    2017-01-01

    Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have been approved with, or are under clinical development with, other targeted therapies including proteasome inhibitors, αCD38 monoclonal antibodies, as well as histone deacetylase (HDAC) inhibitors for combination therapy. HDAC inhibitors broadly targeting Class I and IIb HDACs have shown potent preclinical efficacy but have frequently demonstrated an undesirable safety profile in combination therapy approaches in clinical studies. Therefore, development of more selective HDAC inhibitors could provide enhanced efficacy with reduced side effects in combination with IMiDs® for the treatment of B-cell malignancies, including multiple myeloma. Here, the second generation selective HDAC6 inhibitor citarinostat (ACY-241), with a more favorable safety profile than non-selective pan-HDAC inhibitors, is shown to synergize with pomalidomide in in vitro assays through promoting greater apoptosis and cell cycle arrest. Furthermore, utilizing a multiple myeloma in vivo murine xenograft model, combination treatment with pomalidomide and ACY-241 leads to increased tumor growth inhibition. At the molecular level, combination treatment with ACY-241 and pomalidomide leads to greater suppression of the pro-survival factors survivin, Myc, and IRF4. The results presented here demonstrate synergy between pomalidomide and ACY-241 in both in vitro and in vivo preclinical models, providing further impetus for clinical development of ACY-241 for use in combination with IMiDs for patients with multiple myeloma and potentially other B-cell malignancies. PMID:28264055

  15. Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage

    PubMed Central

    Ghylin, Trevor W; Garcia, Sarahi L; Moya, Francisco; Oyserman, Ben O; Schwientek, Patrick; Forest, Katrina T; Mutschler, James; Dwulit-Smith, Jeffrey; Chan, Leong-Keat; Martinez-Garcia, Manuel; Sczyrba, Alexander; Stepanauskas, Ramunas; Grossart, Hans-Peter; Woyke, Tanja; Warnecke, Falk; Malmstrom, Rex; Bertilsson, Stefan; McMahon, Katherine D

    2014-01-01

    Members of the acI lineage of Actinobacteria are the most abundant microorganisms in most freshwater lakes; however, our understanding of the keys to their success and their role in carbon and nutrient cycling in freshwater systems has been hampered by the lack of pure cultures and genomes. We obtained draft genome assemblies from 11 single cells representing three acI tribes (acI-A1, acI-A7, acI-B1) from four temperate lakes in the United States and Europe. Comparative analysis of acI SAGs and other available freshwater bacterial genomes showed that acI has more gene content directed toward carbohydrate acquisition as compared to Polynucleobacter and LD12 Alphaproteobacteria, which seem to specialize more on carboxylic acids. The acI genomes contain actinorhodopsin as well as some genes involved in anaplerotic carbon fixation indicating the capacity to supplement their known heterotrophic lifestyle. Genome-level differences between the acI-A and acI-B clades suggest specialization at the clade level for carbon substrate acquisition. Overall, the acI genomes appear to be highly streamlined versions of Actinobacteria that include some genes allowing it to take advantage of sunlight and N-rich organic compounds such as polyamines, di- and oligopeptides, branched-chain amino acids and cyanophycin. This work significantly expands the known metabolic potential of the cosmopolitan freshwater acI lineage and its ecological and genetic traits. PMID:25093637

  16. Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage.

    PubMed

    Ghylin, Trevor W; Garcia, Sarahi L; Moya, Francisco; Oyserman, Ben O; Schwientek, Patrick; Forest, Katrina T; Mutschler, James; Dwulit-Smith, Jeffrey; Chan, Leong-Keat; Martinez-Garcia, Manuel; Sczyrba, Alexander; Stepanauskas, Ramunas; Grossart, Hans-Peter; Woyke, Tanja; Warnecke, Falk; Malmstrom, Rex; Bertilsson, Stefan; McMahon, Katherine D

    2014-12-01

    Members of the acI lineage of Actinobacteria are the most abundant microorganisms in most freshwater lakes; however, our understanding of the keys to their success and their role in carbon and nutrient cycling in freshwater systems has been hampered by the lack of pure cultures and genomes. We obtained draft genome assemblies from 11 single cells representing three acI tribes (acI-A1, acI-A7, acI-B1) from four temperate lakes in the United States and Europe. Comparative analysis of acI SAGs and other available freshwater bacterial genomes showed that acI has more gene content directed toward carbohydrate acquisition as compared to Polynucleobacter and LD12 Alphaproteobacteria, which seem to specialize more on carboxylic acids. The acI genomes contain actinorhodopsin as well as some genes involved in anaplerotic carbon fixation indicating the capacity to supplement their known heterotrophic lifestyle. Genome-level differences between the acI-A and acI-B clades suggest specialization at the clade level for carbon substrate acquisition. Overall, the acI genomes appear to be highly streamlined versions of Actinobacteria that include some genes allowing it to take advantage of sunlight and N-rich organic compounds such as polyamines, di- and oligopeptides, branched-chain amino acids and cyanophycin. This work significantly expands the known metabolic potential of the cosmopolitan freshwater acI lineage and its ecological and genetic traits.

  17. Management of focal cartilage defects in the knee - Is ACI the answer?

    PubMed

    Strauss, Eric J; Fonseca, Lauren E; Shah, Mehul R; Yorum, Thomas

    2011-01-01

    Injuries to the articular cartilage of the knee are common. They alter the normal distribution of weightbearing forces and predispose patients to the development of degenerative joint disease. The management of focal chondral lesions continues to be problematic for the treating orthopaedic surgeon. Although many treatment options are currently available, none fulfill the criteria for an ideal repair solution: a hyaline repair tissue that completely fills the defect and integrates well with the surrounding normal cartilage. Autologous chondrocyte implantation (ACI) is a relatively new cell-based treatment method for full-thickness cartilage injuries that in recent years has increased in popularity, with early studies showing promising results. The current article reviews the nature of cartilage lesions in the knee and the treatment modalities utilized in their management, focusing on the role ACI plays in the surgical treatment of these complex injuries.

  18. Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.

    PubMed

    Shull, James D; Lachel, Cynthia M; Strecker, Tracy E; Spady, Thomas J; Tochacek, Martin; Pennington, Karen L; Murrin, Clare R; Meza, Jane L; Schaffer, Beverly S; Flood, Lisa A; Gould, Karen A

    2006-07-01

    Unilateral renal agenesis (URA) is a common developmental defect in humans, occurring at a frequency of approximately 1 in 500-1,000 births. Several genetic syndromes include bilateral or unilateral renal agenesis as an associated phenotype. However, URA frequently occurs in individuals not afflicted by these syndromes and is often asymptomatic. Although it is clear that genetic factors contribute to the etiology of URA, the genetic bases of URA are poorly defined at this time. ACI rats, both males and females, exhibit URA at an incidence of 5%-15%. In this article we characterize the incidence of URA in female and male F(1), F(2), and backcross (BC) progeny from reciprocal genetic crosses between the ACI strain and the unaffected Brown Norway (BN) strain. Through interval mapping analyses of 353 phenotypically defined female F(2) progeny, we mapped to rat Chromosome 14 (RNO14) a genetic locus, designated Renag1 (Renal agenesis 1), that serves as the major determinant of URA in these crosses. Further genotypic analyses of URA-affected female and male F(2) and BC progeny localized Renag1 to a 14.4-Mb interval on RNO14 bounded by markers D14Rat50 and D14Rat12. The data from these genetic studies suggest that the ACI allele of Renag1 acts in an incompletely dominant and incompletely penetrant manner to confer URA.

  19. Diallyl sulfide inhibits diethylstilbesterol-induced DNA adducts in the breast of female ACI rats.

    PubMed

    Green, M; Wilson, C; Newell, O; Sadrud-Din, S; Thomas, R

    2005-09-01

    Diethylstilbestrol (DES) is metabolized to reactive intermediates that produce DNA adducts and ultimately cancer. Diallyl sulfide (DAS) has been shown to inhibit the metabolism of several procarcinogens. The ability of DES to produce DNA adducts in microsomal, mitochondrial, and nuclear in vitro metabolic systems and in the breast of female ACI rats, as well as ability of DAS to inhibit DNA adducts were investigated. Microsomes, mitochondria, and nuclei isolated from breast tissue of female ACI rats were used to catalyze oxidation reactions. Female ACI rats were treated i.p. as follows: (1) corn oil, (2) 200mg/kg DES, (3) 200mg/kg DES/200mg/kg of DAS, (4) 200mg/kg DES/400mg/kg DAS. DES produced DNA adducts in each metabolic system. The relative adduct levels were 2.1 x 10(-4), 6.2 x 10(-6), and 2.9 x 10(-7) in microsomal, mitochondrial, and nuclear reactions, respectively. DAS inhibited DNA adducts in each metabolic system. The percent inhibition ranged from 86% in microsomes to 93% in nuclei. DES produced DNA adducts in mtDNA and nDNA. DAS completely inhibited the DES-induced mtDNA adducts and caused a dose dependent decrease in nDNA adduct formation. These findings suggest that DAS could inhibit DES-induced breast cancer by inhibiting its metabolism.

  20. Deprotonation yields, pKa, and aci-nitro decay rates in some substituted o-nitrobenzaldehydes.

    PubMed

    Abbruzzetti, Stefania; Carcelli, Mauro; Rogolino, Dominga; Viappiani, Cristiano

    2003-07-01

    In this paper we report the deprotonation yields, the pKa, and decay kinetics of the aci-nitro intermediates of some substituted 2-nitrobenzaldehydes that can be used as photoactivatable caged proton compounds. The decay of the aci-nitro absorbance for 2-nitrobenzaldehyde occurs within a few nanoseconds from photoexcitation. Addition of electron donating methoxy substituents at positions 4 and 5 leads to lower deprotonation yields, higher pKa, and slower decays of the aci-nitro intermediates. On the contrary, the decay rate is accelerated by the introduction of an electron-withdrawing Cl atom at position 4 in the phenyl ring, with little influence on the deprotonation yield and pKa of the aci-nitro intermediate.

  1. Is autologous chondrocyte implantation (ACI) an adequate treatment option for repair of cartilage defects in paediatric patients?

    PubMed

    Kaszkin-Bettag, Marietta

    2013-08-01

    Cartilage lesions in the knee of juvenile patients require an effective repair to regain life-long functional activity of the joint. Autologous chondrocyte implantation (ACI) is discussed to be advantageous over other methods for cartilage repair regarding long-term outcome. ACI has successfully been applied in juvenile patients, although currently recommended for patients ≥18 years of age. Only few controlled clinical trials present evidence of efficacy and safety of ACI in adolescent patients. ACI products have to undergo the process of a marketing authorisation application, including the submission of a paediatric investigation plan (PIP). Data from prospective clinical studies or retrospective collection of long-term data in paediatric patients should be submitted for risk-benefit evaluation by the Paediatric Committee (PDCO).

  2. Evolution of temperature-dependent charge transfer inefficiency correction for ACIS on the Chandra X-ray Observatory

    NASA Astrophysics Data System (ADS)

    Grant, Catherine E.; Bautz, Marshall W.; Durham, R. Nick; Plucinsky, Paul P.

    2016-07-01

    As ACIS on the Chandra X-ray Observatory enters its seventeenth year of operation, it continues to perform well and produce spectacular scientific results. The response of ACIS has evolved over the lifetime of the observatory due to radiation damage and aging of the spacecraft. The ACIS instrument team developed a software tool which applies a correction to each X-ray event and mitigates charge transfer inefficiency (CTI) and spectral resolution degradation. The behavior of the charge traps that cause CTI are temperature dependent, however, and warmer temperatures reduce the effectiveness of the correction algorithm. As the radiator surfaces on Chandra age, ACIS cooling has become less efficient and temperatures can increase by a few degrees. A temperature-dependent component was added to the CTI correction algorithm in 2010. We present an evaluation of the effectiveness of this algorithm as the radiation damage and thermal environment continue to evolve and suggest updates to improve the calibration fidelity.

  3. Japan Studies Association Journal, 1998.

    ERIC Educational Resources Information Center

    Speaker, Richard B., Jr., Ed.; Kawada, Louise Myers, Ed.

    1998-01-01

    This journal presents new perspectives and materials on Japan that are engaging, relatively jargon-free, and shaped so that their usefulness in a college classroom is readily apparent. The journal represents an example of the potential for genuine scholarship that lies within interdisciplinary studies. Articles are divided among three thematic…

  4. Japan Studies Association Journal, 2001.

    ERIC Educational Resources Information Center

    Reichel, Philip L., Ed.

    2001-01-01

    This journal presents new perspectives and materials on Japan that are engaging, relatively jargon-free, and shaped so that their usefulness in a college classroom is readily apparent. The journal represents an example of the potential for genuine scholarship that lies within interdisciplinary studies. Articles grouped under the topic of…

  5. Ecosystem Journalism

    ERIC Educational Resources Information Center

    Robertson, Amy; Mahlin, Kathryn

    2005-01-01

    If the organisms in a prairie ecosystem created a newspaper, what would it look like? What important news topics of the ecosystem would the organisms want to discuss? Imaginative and enthusiastic third-grade students were busy pondering these questions as they tried their hands at "ecosystem journalism." The class had recently completed…

  6. Determination of partition and diffusion coefficients of formaldehyde in selected building materials and impact of relative humidity (journal)

    EPA Science Inventory

    The partition and effective diffusion coefficients of formaldehyde were measured for three materials (conventional gypsum wallboard, "green" gypsum wallboard, and "green" carpet) under three relative humidity (RH) conditions (20%, 50% and 70% RH). A dynamic dual-chamber test meth...

  7. Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.

    PubMed

    Yamashita, Satoshi; Suzuki, Shugo; Nomoto, Tomoko; Kondo, Yasushi; Wakazono, Kuniko; Tsujino, Yoshimi; Sugimura, Takashi; Shirai, Tomoyuki; Homma, Yukio; Ushijima, Toshikazu

    2005-04-01

    ACI/Seg (ACI) rats develop prostate cancers spontaneously with aging, similar to humans. Here, to identify genes involved in prostate cancer susceptibility, we did linkage analysis and oligonucleotide microarray analysis. Linkage analysis was done using 118 effective rats, and prostate cancer susceptibility 1 (Pcs1), whose ACI allele dominantly induced prostate cancers, was mapped on chromosome 19 [logarithm of odds (LOD) score of 5.0]. PC resistance 1 (Pcr1), whose ACI allele dominantly and paradoxically suppressed the size of prostate cancers, was mapped on chromosome 2 (LOD score of 5.0). When linkage analysis was done in 51 rats with single or no macroscopic testicular tumors, which had larger prostates and higher testosterone levels than those with bilateral testicular tumors, Pcs2 and Pcr2 were mapped on chromosomes 20 and 1, respectively. By oligonucleotide microarray analysis with 8,800 probe sets and confirmation by quantitative reverse transcription-PCR, only two genes within these four loci were found to be differentially expressed >1.8-fold. Membrane metalloendopeptidase (Mme), known to inhibit androgen-independent growth of prostate cancers, on Pcr1 was expressed 2.0- to 5.5-fold higher in the ACI prostate, in accordance with its paradoxical effect. Cdkn1a on Pcs2 was expressed 1.5- to 4.5-fold lower in the ACI prostate. Additionally, genes responsible for testicular tumors and unilateral renal agenesis were mapped on chromosomes 11 and 14, respectively. These results showed that prostate cancer susceptibility of ACI rats involves at least four loci, and suggested Mme and Cdkn1a as candidates for Pcr1 and Pcs2.

  8. EVALUATION OF FUNGAL GROWTH ON FIBERGLASS DUCT MATERIALS FOR VARIOUS MOISTURE, SOIL, USE, AND TEMPERATURE CONDITIONS (JOURNAL)

    EPA Science Inventory

    The paper gives results of a series of experiments, each lasing 6 weeks, conducted in static environmental chambers to assess some of the conditions that may impact the ability of a variety of fiberglass materials to support the growth of a fungus, Penicillium chrysogenum. (NOTE:...

  9. The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains.

    PubMed

    Avsaroglu, H; Sommer, R; Hellebrekers, L J; van Zutphen, L F M; van Lith, H A

    2008-04-01

    Buprenorphine is a partial mu, kappa agonist that has been shown to influence spontaneous behaviour in animals. Previously, we have demonstrated significant differences in the analgesic response to buprenorphine between the August Copenhagen Irish (ACI)/SegHsd and the Brown Norway (BN)/RijHsd inbred rat strains. The purpose of this study was to determine whether these strains also differed in their behavioural response to buprenorphine in order to provide an additional parameter for the genetic analysis and localization of genes involved in this response. Male and female rats of both strains were used (n = 6/strain/sex) for this study. Each rat was subjected, respectively, to three treatment regimens at 15:00 h: (A) unchallenged; (B) intravenous saline; (C) intravenous buprenorphine (0.05 mg/kg) according to a crossover design. The relative duration (s/h) of locomotion, grooming, drinking and eating behaviour was subsequently determined from 15:30 to 07:00 h using the automatic registration system, Laboratory Animal Behaviour Registration and Analysis System(trade mark). Significant strain differences were observed in unchallenged behaviour between the ACI and the BN rats. ACI rats, but not BN rats, responded to buprenorphine treatment with decreased levels of locomotion, drinking and eating behaviour. The same treatment resulted in an increased grooming behaviour in both strains. Slight but significant sex differences were observed for locomotion and eating in the analysis of variance procedure, but did not reach the level of statistical significance in the multiple comparison procedure. The results of this study emphasize the possibility that strain-specific effects must be taken into account when using behavioural parameters for the assessment of the analgesic effects of buprenorphine in rats.

  10. Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats.

    PubMed

    Singh, Bhupendra; Mense, Sarah M; Bhat, Nimee K; Putty, Sandeep; Guthiel, William A; Remotti, Fabrizio; Bhat, Hari K

    2010-09-01

    Phytoestrogens are plant compounds that structurally mimic the endogenous estrogen 17beta-estradiol (E(2)). Despite intense investigation, the net effect of phytoestrogen exposure on the breast remains unclear. The objective of the current study was to examine the effects of quercetin on E(2)-induced breast cancer in vivo. Female ACI rats were given quercetin (2.5 g/kg food) for 8 months. Animals were monitored weekly for palpable tumors, and at the end of the experiment, rats were euthanized, breast tumor and different tissues excised so that they could be examined for histopathologic changes, estrogen metabolic activity and oxidant stress. Quercetin alone did not induce mammary tumors in female ACI rats. However, in rats implanted with E(2) pellets, co-exposure to quercetin did not protect rats from E(2)-induced breast tumor development with 100% of the animals developing breast tumors within 8 months of treatment. No changes in serum quercetin levels were observed in quercetin and quercetin+E(2)-treated groups at the end of the experiment. Tumor latency was significantly decreased among rats from the quercetin+E(2) group relative to those in the E(2) group. Catechol-O-methyltransferase (COMT) activity was significantly downregulated in quercetin-exposed mammary tissue. Analysis of 8-isoprostane F(2alpha) (8-iso-PGF(2alpha)) levels as a marker of oxidant stress showed that quercetin did not decrease E(2)-induced oxidant stress. These results indicate that quercetin (2.5 g/kg food) does not confer protection against breast cancer, does not inhibit E(2)-induced oxidant stress and may exacerbate breast carcinogenesis in E(2)-treated ACI rats. Inhibition of COMT activity by quercetin may expose breast cells chronically to E(2) and catechol estrogens. This would permit longer exposure times to the carcinogenic metabolites of E(2) and chronic exposure to oxidant stress as a result of metabolic redox cycling to estrogen metabolites, and thus quercetin may exacerbate E(2

  11. Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats

    SciTech Connect

    Singh, Bhupendra; Mense, Sarah M.; Bhat, Nimee K.; Putty, Sandeep; Guthiel, William A.; Remotti, Fabrizio; Bhat, Hari K.

    2010-09-01

    Phytoestrogens are plant compounds that structurally mimic the endogenous estrogen 17{beta}-estradiol (E{sub 2}). Despite intense investigation, the net effect of phytoestrogen exposure on the breast remains unclear. The objective of the current study was to examine the effects of quercetin on E{sub 2}-induced breast cancer in vivo. Female ACI rats were given quercetin (2.5 g/kg food) for 8 months. Animals were monitored weekly for palpable tumors, and at the end of the experiment, rats were euthanized, breast tumor and different tissues excised so that they could be examined for histopathologic changes, estrogen metabolic activity and oxidant stress. Quercetin alone did not induce mammary tumors in female ACI rats. However, in rats implanted with E{sub 2} pellets, co-exposure to quercetin did not protect rats from E{sub 2}-induced breast tumor development with 100% of the animals developing breast tumors within 8 months of treatment. No changes in serum quercetin levels were observed in quercetin and quercetin + E{sub 2}-treated groups at the end of the experiment. Tumor latency was significantly decreased among rats from the quercetin + E{sub 2} group relative to those in the E{sub 2} group. Catechol-O-methyltransferase (COMT) activity was significantly downregulated in quercetin-exposed mammary tissue. Analysis of 8-isoprostane F{sub 2{alpha}} (8-iso-PGF{sub 2{alpha}}) levels as a marker of oxidant stress showed that quercetin did not decrease E{sub 2}-induced oxidant stress. These results indicate that quercetin (2.5 g/kg food) does not confer protection against breast cancer, does not inhibit E{sub 2}-induced oxidant stress and may exacerbate breast carcinogenesis in E{sub 2}-treated ACI rats. Inhibition of COMT activity by quercetin may expose breast cells chronically to E{sub 2} and catechol estrogens. This would permit longer exposure times to the carcinogenic metabolites of E{sub 2} and chronic exposure to oxidant stress as a result of metabolic redox

  12. VizieR Online Data Catalog: A deep Chandra ACIS survey of M51 (Kuntz+, 2016)

    NASA Astrophysics Data System (ADS)

    Kuntz, K. D.; Long, K. S.; Kilgard, R. E.

    2016-11-01

    This deep study of M51 is composed of 107ks of archival Chandra observations, to which we have added another 745ks of observations. All of the observations were made with the ACIS-S array. M51 has been observed extensively with HST. In particular, essentially all of M51 and its companion NGC 5195 was imaged with Advanced Camera for Surveys (ACS) in V, R, and I (F435W, F555W, F814W) and Hα (F658N) as a Hubble Legacy Project (Proposal ID 10452, PI: S. Beckwith). (4 data files).

  13. Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.

    PubMed

    Matsuyama, Mutsushi; Haneda, Chiemi; Kato, Kazuo

    2013-08-01

    The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.

  14. Error Probability of MRC in Frequency Selective Nakagami Fading in the Presence of CCI and ACI

    NASA Astrophysics Data System (ADS)

    Rahman, Mohammad Azizur; Sum, Chin-Sean; Funada, Ryuhei; Sasaki, Shigenobu; Baykas, Tuncer; Wang, Junyi; Harada, Hiroshi; Kato, Shuzo

    An exact expression of error rate is developed for maximal ratio combining (MRC) in an independent but not necessarily identically distributed frequency selective Nakagami fading channel taking into account inter-symbol, co-channel and adjacent channel interferences (ISI, CCI and ACI respectively). The characteristic function (CF) method is adopted. While accurate analysis of MRC performance cannot be seen in frequency selective channel taking ISI (and CCI) into account, such analysis for ACI has not been addressed yet. The general analysis presented in this paper solves a problem of past and present interest, which has so far been studied either approximately or in simulations. The exact method presented also lets us obtain an approximate error rate expression based on Gaussian approximation (GA) of the interferences. It is shown, especially while the channel is lightly faded, has fewer multipath components and a decaying delay profile, the GA may be substantially inaccurate at high signal-to-noise ratio. However, the exact results also reveal an important finding that there is a range of parameters where the simpler GA is reasonably accurate and hence, we don't have to go for more involved exact expression.

  15. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats.

    PubMed

    Aiyer, Harini S; Srinivasan, Cidambi; Gupta, Ramesh C

    2008-01-01

    Estrogen acts as a complete mammary carcinogen in ACI rats. Prevention studies in this model allowed us to identify agents that are effective against estrogen-induced mammary carcinogenesis. In this study, we investigated efficacy of dietary berries and ellagic acid to reduce estrogen-mediated mammary tumorigenesis. Female ACI rats (8-9 wk) were fed either AIN-93M diet (n = 25) or diet supplemented with either powdered blueberry (n = 19) and black raspberry (n = 19) at 2.5% wt/wt each or ellagic acid (n = 22) at 400 ppm. Animals received implants of 17beta-estradiol 2 wk later, were palpated periodically for mammary tumors, and were euthanized after 24 wk. No differences were found in tumor incidence at 24 wk; however, tumor volume and multiplicity were reduced significantly after intervention. Compared with the control group (average tumor volume = 685 +/- 240 mm3 and tumor multiplicity = 8.0 +/- 1.3), ellagic acid reduced the tumor volume by 75% (P < 0.005) and tumor multiplicity by 44% (P < 0.05). Black raspberry followed closely, with tumor volume diminished by > 69% (P < 0.005) and tumor multiplicity by 37% (P = 0.07). Blueberry showed a reduction (40%) only in tumor volume. This is the first report showing the significant efficacy of both ellagic acid and berries in the prevention of solely estrogen-induced mammary tumors.

  16. Proton-transfer reactions of nitroalkanes: the role of aci-nitro species.

    PubMed

    Sato, Makoto; Kitamura, Yutaka; Yoshimura, Nobuyoshi; Yamataka, Hiroshi

    2009-02-06

    Proton-transfer reactions of two systems, ionization of a series of small carbon acids in water (the Pearson system) and reactions of substituted phenylnitromethanes, were examined in detail computationally. Comparison of experimental reactivity and pK(a) with calculated relative activation barrier and reaction energy for the Pearson system suggested that the origin of the well-know nitroalkane anomaly does not reside in the reactivity but in the equilibrium. For the reactions of substituted phenylnitromethanes, proton transfers among three species, PhCH(2)NO(2), PhCHNO(2)(-), and PhCH=NO(2)H, were examined, and the role of the aci-nitro species (PhCH=NO(2)H) was evaluated on the basis of its stability and reactivity. Protonation of PhCHNO(2)(-) by H(2)O was suggested to occur kinetically on the oxygen site, but due to its instability PhCH=NO(2)H does not contribute to the overall reaction energetics. The protonation of PhCHNO(2)(-) under acidic conditions occurs on the oxygen site to give PhCH=NO(2)H both kinetically and thermodynamically. The aci-nitro species thus formed appears to give PhCH(2)NO(2) via intramolecular H(2)O-mediated proton transfer, but a possibility of the route through PhCHNO(2)(-)-C-protonation would not be fully eliminated.

  17. Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa.

    PubMed

    Cohen, Joyce K; Cai, Li-Qun; Zhu, Yuan-Shan; La Perle, Krista M D

    2007-08-01

    Many lesions associated with aging have been well-characterized in various strains of rats. Although documented in Sprague-Dawley and spontaneously hypertensive rats, polyarteritis nodosa has not previously been reported in ACI/SegHsd rats. ACII SegHsd rats were maintained on high-fat (40.5%), low-fat (11.6%), and high-fat to low-fat dietary protocols to examine the correlation between dietary fat and the regulation of prostate 5alpha-reductase gene expression and prostate cancer. Seven rats died unexpectedly with hemoabdomen and rupture of the pancreaticoduodenal artery secondary to polyarteritis nodosa (PAN). The purpose of this study was to analyze the pathologic findings in these and the remaining ACI/SegHsd rats and to correlate the level of dietary fat with the presence of PAN, arterial rupture, and hemoabdomen. Approximately 65% of the rats had evidence of PAN by histopathology, with a 24% incidence of arterial rupture. Additional lesions noted included an 88% incidence of chronic progressive nephropathy (CPN) and a 32% incidence of cartilaginous foci in the aortic valve. We found no association between the percentage of dietary fat and incidence of PAN, CPN, or cardiac cartilage. Although arterial rupture is a known complication of polyarteritis nodosa in humans, this case series is the first to document arterial rupture and hemoabdomen in rats with PAN.

  18. Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.

    PubMed

    Hopper, A T; Witiak, D T; Ziemniak, J

    1998-02-12

    An efficient and convergent synthesis has been developed for the production of 3,4-dihydroxy-5-[4-(2-((2Z)-hexenyl)phenyl)-3-(1Z)-but enyl]-2 (5H)-furanone (12d). This hydrophobic antioxidant is a stable conformationally constrained mimic of arachidonic acid (AA) (1) and its respective aci-reductone analogue (2). Pd(0)-catalyzed cross-coupling of 5-(3-butynyl)-3,4-dihydroxy-2(5H)-furanone (7) with 2-((2Z)-hexenyl)iodobenzene (8d) followed by Lindlar catalyzed hydrogenation produces 12d. Butynyl intermediate 7 is prepared from 2-(benzyloxy)-5-deoxyascorbic acid (15) by iodination (I2, PPh3, Imd), iodo substitution with lithium acetylide ethylenediamine complex (LiAEDA, HMPA, -5 degrees C), and benzyl group cleavage (Ac2O, Pyr, BCl3). The utility of this synthetic method was demonstrated by the synthesis of analogues 10e-k. Biological testing revealed that certain of these antioxidants inhibit both cyclooxygenase (COX) and 5-lipoxygenase (5-LO) with comparable efficacy as reported for aspirin and zileuton, respectively. The antioxidant activity of these aci-reductones, measured as a function of their inhibitory effect on CCl4-induced lipid peroxidation of hepatic microsomes, exceeds that produced by alpha-tocopherol. Synthetic routes and initial structure-activity relationships (SAR) for these novel mixed functioning antioxidants are presented.

  19. Observed On-Orbit Background of the ACIS Detector on the Chandra X-Ray Observatory

    NASA Technical Reports Server (NTRS)

    Plucinsky, P. P.; Virani, S. N.

    2000-01-01

    We have analyzed calibration data acquired during the Orbital Activation and Checkout (OAC) phase of the Chandra X-ray Observatory (CXO) mission in order to characterize the background of the Advanced CCD Imaging Spectrometer (ACIS) produced by charged particles and non-cosmic X-rays. The ACIS instrument contains 8 Front-Illuminated (FI) CCDs and 2 Back-Illuminated (BI) CCDs. The FI and BI CCD)s exhibit dramatically different responses to enhancements in the particle flux. The F1 CCDs show relatively little increase in the overall count rate, typical increases are 1 - 3 counts/s; the BI CCDs show large excursions to as high as 100 counts/s. The duration of these intervals of enhanced background are highly variable ranging from 100 s to 5000 s. The spatial distribution of these background events is relatively flat across the power-law. The events produce morphologies which are similar to cosmic X-ray events, so that morphology alone cannot be used as a rejection criterion. We explore the correlation of these times of high background with the data from Chandra's on-board radiation monitor, the EPHIN (Electron, Proton, Helium Instrument particle detector) instrument and archival data from the Advanced Composition Explorer (ACE) satellite. We discuss strategies for observers to identify and exclude times of high background and to model and subtract the background events from their data.

  20. Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.

    PubMed

    Ruhlen, Rachel L; Willbrand, Dana M; Besch-Williford, Cynthia L; Ma, Lixin; Shull, James D; Sauter, Edward R

    2009-10-01

    The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5-7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.

  1. Mammary tumor induction in ACI rats exposed to low levels of 17beta-estradiol.

    PubMed

    Ravoori, Srivani; Vadhanam, Manicka V; Sahoo, Sunati; Srinivasan, Cidambi; Gupta, Ramesh C

    2007-07-01

    Animal models play a major role in understanding the etiology, molecular mechanisms, strategizing intervention and treatment of human diseases. ACI, an inbred line derived from August and Copenhagen strains, is unique for its susceptibility to estrogen-induced mammary tumors. Histologically and in many molecular aspects, the tumors formed in these rats are similar to human breast cancers. Previous studies have shown high mortality and significant weight loss in this model associated with pituitary gland abnormality. We hypothesized that this could be due to overwhelming the biological system with estrogen. Three groups of female ACI rats (7-8 weeks) received either 3-cm sham silastic implants, or the conventional 3-cm silastic implants containing 27 mg of 17beta-estradiol, or 1.2-cm silastic implants containing 9 mg 17beta-estradiol. The sham and 3-cm implant rats were euthanized at 180 days while the 1.2-cm implant rats were euthanized at 240 days. The 1.2-cm implants resulted in significantly reduced serum estrogen levels and pituitary gland size. Animals with 1.2-cm implants had 100% tumor incidence, while not all rats developed tumors with 3-cm implants. Both the tumor burden (from 1,011+/-402 to 2,324+/-454 mm(3); p=0.01) and tumor multiplicity (from 5.78+/-1.4 to 7.6+/-1.04) increased by lowering the estrogen dose, and the inter-animal variability in the tumor indices decreased. Finally, the weight of the pituitary gland was also significantly (p=0.0004) reduced (from 178+/-23.5 mg to 80+/-8.9 mg) and the mortality rate decreased from 42% to 0% (p=0.01). Our data indicate that the improvised model will provide valuable insights into the molecular alterations in the estrogen-induced mammary tumorigenesis and will be ideal for inhibition studies.

  2. Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats.

    PubMed

    Das Gupta, Soumyasri; So, Jae Young; Wall, Brian; Wahler, Joseph; Smolarek, Amanda K; Sae-Tan, Sudathip; Soewono, Kelvin Y; Yu, Haixiang; Lee, Mao-Jung; Thomas, Paul E; Yang, Chung S; Suh, Nanjoo

    2015-09-01

    Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rodent mammary carcinogenesis due to their high sensitivity to estrogen. Female rats were implanted with 9 mg of 17β-estradiol (E2) in silastic tubings and fed with control or 0.3% γ-TmT diet for 1, 3, 7, and 14 d. γ-TmT increased the levels of tocopherols and their metabolites in the serum and mammary glands of the rats. Histological analysis revealed mammary hyperplasia in the E2 treated rats fed with control or γ-TmT diet. γ-TmT decreased the levels of E2-induced nitrosative and oxidative stress markers, nitrotyrosine, and 8-oxo-dG, respectively, in the hyperplastic mammary tissues. 8-Isoprostane, a marker of oxidative stress in the serum, was also reduced by γ-TmT. Noticeably, γ-TmT stimulated Nrf2-dependent antioxidant response in the mammary glands of E2 treated rats, evident from the induced mRNA levels of Nrf2 and its downstream antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. Therefore, inhibition of nitrosative/oxidative stress through induction of antioxidant response is the primary effect of γ-TmT in early stages of E2-induced mammary hyperplasia. Due to its cytoprotective activity, γ-TmT could be a potential natural agent for the chemoprevention of estrogen-induced breast cancer.

  3. Standardized cartilage biopsies from the intercondylar notch for autologous chondrocyte implantation (ACI).

    PubMed

    Niemeyer, Philipp; Pestka, Jan M; Kreuz, Peter C; Salzmann, Gian M; Köstler, Wolfgang; Südkamp, Norbert P; Steinwachs, Matthias

    2010-08-01

    Autologous chondrocyte implantation (ACI) is an established therapy for the treatment of cartilage defects across the knee joint. Even though different techniques for initial biopsy have been described, the exact location, depth, and volume of the biopsy are chosen individually by the treating surgeon. This study evaluated 252 consecutive cartilage biopsies taken from the intercondylar notch with a standardized hollow cylinder system for the isolation and in vitro cultivation of human chondrocytes assigned to ACI. All biopsies were assessed for weight of total cartilage obtained, cartilage biopsy weight per cylinder, biopsy cylinder quality, and initial cell count after digestive cellular isolation as well as cell vitality. Parameters were correlated with individual patient parameters. Mean patient age was 35.1 years (median 35.9; range 14.7-56.4). Adequate amounts of cartilage assigned to chondrocyte in vitro cultivation could be harvested in all cases. The mean overall biopsy weight averaged 75.5 mg (SD +/- 44.9) and could be identified as main factor for initial cell number (mean 1.05E+05; SD +/- 7.44E+04). No correlation was found between the initial cell count and patient age (correlation coefficient r = 0.005) or grade of joint degeneration (r = 0.040). Concerning cell viability, a total of 4.4% (SD + 3.0) of the chondrocytes harvested were apoptotic. Cartilage biopsies from the intercondylar notch using a standardized hollow cylinder system provides a reliable, safe, and successful method to obtain articular cartilage for further in vitro cultivation of articular chondrocytes to achieve autologous chondrocyte transplantation.

  4. Antioxidant butylated hydroxyanisole inhibits estrogen-induced breast carcinogenesis in female ACI rats.

    PubMed

    Singh, Bhupendra; Mense, Sarah M; Remotti, Fabrizio; Liu, Xinhua; Bhat, Hari K

    2009-01-01

    Exposure to estrogens is suggested to be a risk factor in human breast cancer development. The mechanisms underlying estrogen-induced cancer have not been fully elucidated. Both estrogen receptor (ER)-mediated proliferative processes and ER-independent generation of oxidative stress are suggested to play important roles in estrogen-induced breast carcinogenesis. In the current study, we investigated the role of oxidative stress in breast carcinogenesis using the ACI rat model of mammary tumorigenesis. Female ACI rats were treated with 17beta-estradiol (E(2)), butylated hydroxyanisole (BHA), or a combination of E(2) + BHA for up to 240 days. Cotreatment of rats with E(2) + BHA reduced estrogen-induced breast tumor development with tumor incidence of 24%, a significant decrease relative to E(2) where tumor incidence was 82%. Proliferative changes in the breast tissue of E(2) + BHA-treated animals were similar to those observed in E(2)-treated animals. Tissue levels of 8-isoprostane, a marker of oxidant stress, as well as the activities of antioxidant enzymes including glutathione peroxidase, superoxide dismutase, and catalase were quantified in the breast tissues of rats treated with E(2) + BHA and compared to activity levels found in E(2)-treated animals and respective age-matched controls. Cotreatment with BHA inhibited E(2)-mediated increases in 8-isoprostane levels as well as activities of antioxidant enzymes. In summary, these data suggest that estrogen-mediated oxidant stress plays a critical role in the development of estrogen-dependent breast cancers and BHA inhibits E(2)-dependent breast carcinogenesis by decreasing oxidant stress.

  5. Journal bearing

    DOEpatents

    Menke, John R.; Boeker, Gilbert F.

    1976-05-11

    1. An improved journal bearing comprising in combination a non-rotatable cylindrical bearing member having a first bearing surface, a rotatable cylindrical bearing member having a confronting second bearing surface having a plurality of bearing elements, a source of lubricant adjacent said bearing elements for supplying lubricant thereto, each bearing element consisting of a pair of elongated relatively shallowly depressed surfaces lying in a cylindrical surface co-axial with the non-depressed surface and diverging from one another in the direction of rotation and obliquely arranged with respect to the axis of rotation of said rotatable member to cause a flow of lubricant longitudinally along said depressed surfaces from their distal ends toward their proximal ends as said bearing members are rotated relative to one another, each depressed surface subtending a radial angle of less than 360.degree., and means for rotating said rotatable bearing member to cause the lubricant to flow across and along said depressed surfaces, the flow of lubricant being impeded by the non-depressed portions of said second bearing surface to cause an increase in the lubricant pressure.

  6. Cytogenetic Assessment of the Rat Cell Line CLS-ACI-1: An in vitro Cell Model for Mycn Overexpression.

    PubMed

    Meles, Susana; Adega, Filomena; Castro, João; Chaves, Raquel

    2015-01-01

    Breast cancer is a complex and heterogeneous disease, and the establishment of cell models in order to properly study the disease at the molecular and cellular level is of utmost importance. Here, we present the cytogenetic characterization and gene expression analysis of the tumoral mammary rat cell line CLS-ACI-1. The use of banding and molecular cytogenetic techniques allowed the description of the complex CLS-ACI-1 karyotype and the identification of breakpoints in clonal chromosome rearrangements. Moreover, a Mycn and Erbb2 comparative expression analysis by RT-qPCR was performed, revealing a high expression level of Mycn in CLS-ACI-1 cells. Moreover, a considerable number of putative mutated genes and chromosome alterations detected through cytogenetic analysis seem to be in the MYCN biological network. Therefore, the CLS-ACI-1 cell line is presented as a promising cell model for the study of the role of MYCN in breast cancer and also as a tool for developing appropriate cancer therapies, namely for Mycn targeting.

  7. Partial genome analysis of Siberian sturgeon alloherpesvirus suggests its close relation to AciHV-2 - short communication.

    PubMed

    Doszpoly, Andor; Shchelkunov, Igor S

    2010-06-01

    Partial genome sequence of a herpes-like virus, isolated from Siberian sturgeon (Acipenser baeri), was determined and subjected to phylogenetic analysis. The virus (SbSHV) has been shown to be the causative agent of an acute disease with high mortality in farmed juvenile sturgeons in Russia. Two fragments (of 7000 and 300 base pairs in length) encompassing 3 complete and 3 partial ORFs were amplified by PCR. Sturgeon herpesvirus strains, classified into species Acipenserid herpesvirus 2 (AciHV-2), have been isolated and partially sequenced from several regions (California, Idaho, Oregon and Canada) of North America from white (A. transmontanus) and shortnose sturgeons (A. brevirostrum). The sequence of the SbSHV strain shared highest identity with that of the Canadian strain originating from shortnose sturgeon. The phylogenetic analysis also confirmed that SbSHV is closely related to AciHV-2 and could also be classified into this virus species. This is the first report on the occurrence of AciHV-2 in Europe. Previously, only another virus species, AciHV-1 has been detected in farmed white sturgeons in Italy. The size and position of ORFs in the examined gene block confirmed that this genomic region is highly conserved in members of the genus Ictalurivirus.

  8. Creating a Health Journal

    MedlinePlus

    ... Health Resources Healthcare Management Working With Your Doctor Creating a Personal Health Journal (Health Diary) Creating a Personal Health Journal (Health Diary) Healthcare ManagementWorking ...

  9. Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.

    PubMed

    Gould, Karen A; Tochacek, Martin; Schaffer, Beverly S; Reindl, Tanya M; Murrin, Clare R; Lachel, Cynthia M; VanderWoude, Eric A; Pennington, Karen L; Flood, Lisa A; Bynote, Kimberly K; Meza, Jane L; Newton, Michael A; Shull, James D

    2004-12-01

    Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segregate as an incompletely dominant trait in crosses to the resistant Copenhagen (COP) strain. In both (ACI x COP)F(2) and (COP x ACI)F(2) populations, we find strong evidence for a major genetic determinant of susceptibility to E2-induced mammary cancer on distal rat chromosome 5. Our data are most consistent with a model in which the ACI allele of this locus, termed Emca1 (estrogen-induced mammary cancer 1), acts in an incompletely dominant manner to increase both tumor incidence and tumor multiplicity as well as to reduce tumor latency in these populations. We also find evidence suggestive of a second locus, Emca2, on chromosome 18 in the (ACI x COP)F(2) population. The ACI allele of Emca2 acts in a dominant manner to increase incidence and decrease latency. Together, Emca1 and Emca2 act independently to modify susceptibility to E2-induced mammary cancer.

  10. European journals on microbiology.

    PubMed

    Ronda, C; Vázquez, M

    1997-12-01

    A survey on the scientific journals dealing with microbiology published in Europe has been carried out. Eighteen European countries publish microbiological journals with the United Kingdom. Netherlands and Germany leading in number of journals on this specialty. Most of the European journals on microbiology are published bimonthly (27%), and English is the most common language used (54%). Most of these journals (86%) are included in some database, but only 36 (25%) are indexed in the six databases studied. Out of the 146 journals registered, 71 (49%), published in 11 European countries, are included in the 1995 Journal Citation Reports (ISI, Philadelphia).

  11. EDITORIAL: Changes to the journal Changes to the journal

    NASA Astrophysics Data System (ADS)

    Zheludev, Nikolay I.

    2010-01-01

    It is a privilege to be Editor-in-Chief of Journal of Optics at this exciting time when the use of light spearheads the development of new technologies in telecommunications, green energy, manufacturing, medicine and defence, just to mention a few. These technological advances, seen by many as the next photonic technological revolution, are underpinned by fundamental and applied research in the following key directions: Nanophotonics and plasmonics Metamaterials and structured photonic materials Nonlinear and ultrafast optics Photonics at the life science interface Information and communication optics Integrated optics systems and devices Material processing with light Propagation, diffraction and scattering This is where Journal of Optics focuses its attention. This editorial marks the first issue of the journal published under the abbreviated name (shortened from Journal of Optics A: Pure and Applied Optics). The name change is just one of a series of changes introduced in the last year, along with the 8 subject sections listed above and the appointment of Section Editors. With the name change, we will also update the look of the journal by introducing colour cover images which will feature some of the most exciting research in the journal. We have retained many of the journal's original selling points: we are found in thousands of libraries around the world, and will continue our policy of free web access to all papers for 30 days after publication, ensuring broad and unrestricted dissemination of your research results. We will also continue our strong and well respected special issue and topical review programmes and we are always grateful to receive new suggestions for special issues or review articles. Along with the Editorial Board, I would like to thank the authors, referees and readers who have contributed to the success of Journal of Optics. The increasing quality and visibility of the journal, as demonstrated by the dramatic increase in its impact factor

  12. Advantages of estimating parameters of photosynthesis model by fitting A-Ci curves at multiple subsaturating light intensities

    NASA Astrophysics Data System (ADS)

    Fu, W.; Gu, L.; Hoffman, F. M.

    2013-12-01

    The photosynthesis model of Farquhar, von Caemmerer & Berry (1980) is an important tool for predicting the response of plants to climate change. So far, the critical parameters required by the model have been obtained from the leaf-level measurements of gas exchange, namely the net assimilation of CO2 against intercellular CO2 concentration (A-Ci) curves, made at saturating light conditions. With such measurements, most points are likely in the Rubisco-limited state for which the model is structurally overparameterized (the model is also overparameterized in the TPU-limited state). In order to reliably estimate photosynthetic parameters, there must be sufficient number of points in the RuBP regeneration-limited state, which has no structural over-parameterization. To improve the accuracy of A-Ci data analysis, we investigate the potential of using multiple A-Ci curves at subsaturating light intensities to generate some important parameter estimates more accurately. Using subsaturating light intensities allow more RuBp regeneration-limited points to be obtained. In this study, simulated examples are used to demonstrate how this method can eliminate the errors of conventional A-Ci curve fitting methods. Some fitted parameters like the photocompensation point and day respiration impose a significant limitation on modeling leaf CO2 exchange. The multiple A-Ci curves fitting can also improve over the so-called Laisk (1977) method, which was shown by some recent publication to produce incorrect estimates of photocompensation point and day respiration. We also test the approach with actual measurements, along with suggested measurement conditions to constrain measured A-Ci points to maximize the occurrence of RuBP regeneration-limited photosynthesis. Finally, we use our measured gas exchange datasets to quantify the magnitude of resistance of chloroplast and cell wall-plasmalemma and explore the effect of variable mesophyll conductance. The variable mesophyll conductance

  13. Combined autologous chondrocyte implantation (ACI) with supra-condylar femoral varus osteotomy, following lateral growth-plate damage in an adolescent knee: 8-year follow-up

    PubMed Central

    2011-01-01

    We report the 8-year clinical and radiographic outcome of an adolescent patient with a large osteochondral defect of the lateral femoral condyle, and ipsilateral genu valgum secondary to an epiphyseal injury, managed with autologous chondrocyte implantation (ACI) and supracondylar re-alignment femoral osteotomy. Long-term clinical success was achieved using this method, illustrating the effective use of re-alignment osteotomy in correcting mal-alignment of the knee, protecting the ACI graft site and providing the optimum environment for cartilage repair and regeneration. This is the first report of the combined use of ACI and femoral osteotomy for such a case. PMID:21418566

  14. Combined autologous chondrocyte implantation (ACI) with supra-condylar femoral varus osteotomy, following lateral growth-plate damage in an adolescent knee: 8-year follow-up.

    PubMed

    Vijayan, Sridhar; Bentley, George

    2011-03-18

    We report the 8-year clinical and radiographic outcome of an adolescent patient with a large osteochondral defect of the lateral femoral condyle, and ipsilateral genu valgum secondary to an epiphyseal injury, managed with autologous chondrocyte implantation (ACI) and supracondylar re-alignment femoral osteotomy. Long-term clinical success was achieved using this method, illustrating the effective use of re-alignment osteotomy in correcting mal-alignment of the knee, protecting the ACI graft site and providing the optimum environment for cartilage repair and regeneration. This is the first report of the combined use of ACI and femoral osteotomy for such a case.

  15. VizieR Online Data Catalog: A deep Chandra ACIS survey of M83 (Long+, 2014)

    NASA Astrophysics Data System (ADS)

    Long, K. S.; Kuntz, K. D.; Blair, W. P.; Godfrey, L.; Plucinsky, P. P.; Soria, R.; Stockdale, C.; Winkler, P. F.

    2014-07-01

    X-ray observations of M83 were all carried out with Chandra/ACIS-S in the "very faint" mode and spaced over a period of one year from 2010 December to 2011 December. We included in our analysis earlier Chandra observations of M83 in 2000 and 2001 totaling 61ks obtained by G. Rieke (Prop ID. 1600489; ObsID 73) and by A. Prestwich (Prop ID. 267005758; ObsID 2064). To support and extend our X-ray study of M83, we have been carrying out a number of other studies of M83, including optical broadband and narrowband imaging with the IMACS camera on Magellan (Blair et al. 2012, Cat. J/ApJS/203/8), optical imaging with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST; W. P. Blair PI, Prop. ID. 12513, Blair et al. 2014ApJ...788...55B), and radio imaging with the Jansky Very Large Array (JVLA; C. Stockdale PI, Prog. ID. 12A-335). Here we describe new 6 and 3cm radio imaging we have obtained from ATCA (Australia Telescope Compact Array) on 2011 April 28, 29, and 30 (table 2). (4 data files).

  16. The rapid A-Ci response: photosynthesis in the phenomic era.

    PubMed

    Stinziano, Joseph R; Morgan, Patrick B; Lynch, Douglas J; Saathoff, Aaron J; McDermitt, Dayle K; Hanson, David T

    2017-03-01

    Phenotyping for photosynthetic gas exchange parameters is limiting our ability to select plants for enhanced photosynthetic carbon gain and to assess plant function in current and future natural environments. This is due, in part, to the time required to generate estimates of the maximum rate of ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) carboxylation (Vc,max ) and the maximal rate of electron transport (Jmax ) from the response of photosynthesis (A) to the CO2 concentration inside leaf air spaces (Ci ). To relieve this bottleneck, we developed a method for rapid photosynthetic carbon assimilation CO2 responses [rapid A-Ci response (RACiR)] utilizing non-steady-state measurements of gas exchange. Using high temporal resolution measurements under rapidly changing CO2 concentrations, we show that RACiR techniques can obtain measures of Vc,max and Jmax in ~5 min, and possibly even faster. This is a small fraction of the time required for even the most advanced gas exchange instrumentation. The RACiR technique, owing to its increased throughput, will allow for more rapid screening of crops, mutants and populations of plants in natural environments, bringing gas exchange into the phenomic era.

  17. Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats.

    PubMed

    Kutanzi, Kristy R; Koturbash, Igor; Bronson, Roderick T; Pogribny, Igor P; Kovalchuk, Olga

    2010-12-10

    Estrogen and ionizing radiation are well-documented human breast carcinogens, yet the exact mechanisms of their deleterious effects on mammary gland remain to be discerned. Here we analyze the balance between cellular proliferation and apoptosis in the mammary glands of rats exposed to estrogen and X-ray radiation and the combined action of these carcinogenic agents. For the first time, we show that combined exposure to estrogen and radiation has a synergistic effect on cell proliferation in the mammary glands of ACI rats, as evidenced by a substantially greater magnitude of cell proliferation, especially after 12 and 18 weeks of treatment, when compared to mammary glands of rats exposed to estrogen or radiation alone. We also demonstrate that an imbalance between cell proliferation and apoptosis, rather than enhanced cell proliferation or apoptosis suppression alone, may be a driving force for carcinogenesis. Our studies further suggest that compromised functional activity of p53 may be one of the mechanisms responsible for the proliferation/apoptosis imbalance. In sum, the results of our study indicate that evaluation of the extent of cell proliferation and apoptosis before the onset of preneoplastic lesions may be a potential biomarker of breast cancer risk after exposure to breast carcinogens.

  18. Microarray analysis of diet-induced alterations in gene expression in the ACI rat prostate.

    PubMed

    Reyes, Niradiz; Iatropoulos, Michael; Mittelman, Abraham; Geliebter, Jan

    2002-08-01

    The natural history of prostate cancer is a multistage process that involves the transition from normal tissue to subclinical cancer, with progression to carcinoma in situ and eventually metastatic disease. Evidence suggests that a high-fat diet plays a critical role in the biology and progression of the disease. ACI rats were maintained for two generations on high beef fat or control diets for 18 months. Affymetrix microarrays were used to analyze the mRNA expression levels in the dorsolateral prostates of rats on the different diets. Approximately 4752 genes and expressed sequence tag (EST) were expressed in the prostates of rats on either diet. Twenty-seven genes were upregulated and 28 genes downregulated in the high beef fat diet. Data analysis indicated that a high beef fat diet affects the expression of genes involved in inflammation, glucose and fatty acid metabolism, androgen metabolism, potential tumor suppression and protein kinase activity, as well as intracellular and extracellular matrix molecules, growth factors and androgen responsive genes. Results from these and future studies will lead to a better understanding of the effect of diet on gene expression in the prostate and facilitate the rational design and assessment of potential dietary programs for prostate cancer prevention.

  19. Atypical fetal prostate development is associated with ipsilateral hypoplasia of the wolffian ducts in the ACI rat.

    PubMed

    Hofkamp, Luke E; Bradley, Sarahann; Geliebter, Jan; Timms, Barry G

    2010-05-01

    For over a half century, the ACI (August x Copenhagen) rat has been a primary model for studying renal agenesis and ipsilateral hypoplasia (IHP) of the Wolffian-derived structures (WDS). Because the ACI rat is also used as a model for prostate research, it is important to examine the relationship of IHP and urogenital sinus (UGS) development. The prostate is dependent on androgens for proper growth and differentiation. Alteration in androgen production and/or delivery to the UGS has the potential to perturbate normal development. In this study, we investigate whether the ipsilateral loss of the WDS is associated with altered prostate development. Digital images of serial-sectioned fetal ACI rat UGS were used to create three-dimensional (3-D) surface-rendered models of the developing prostate, seminal vesicle, vas deferens, and utricle on gestational day 21. The number and volume of prostate ducts developing from the UGS were calculated from the 3-D model data. Animals exhibiting IHP had a significant decrease in total fetal prostate volume (40%; P < 0.005) with significant regional specific differences when compared with normal male ACI rats. Anatomical and histological differences in the utricle, abnormal histology of the ipsilateral testes, and a truncation of the ipsilateral Wolffian ductal mesenchyme were also seen in the animals with IHP. Additional research is needed to further understand the mechanisms and consequences of IHP on prostate growth and development. Alterations to normal prenatal development of the male accessory sex organs can have important consequences for the growth and morphology of the adult gland.

  20. Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment.

    PubMed

    Provoost, Abraham P; Shiozawa, Masahide; Van Dokkum, Richard P E; Jacob, Howard J

    2002-02-28

    The genetically hypertensive fawn-hooded (FHH/Eur) rat is characterized by the early presence of systolic and glomerular hypertension, progressive proteinuria (UPV), and albuminuria (UAV), and focal glomerulosclerosis, resulting in premature death from renal failure. Previous studies showed that at least five genetic loci (Rf-1 to Rf-5) were linked to the development of renal impairment. Of these five, Rf-1 appears to play a major role. To study the impact of Rf-1 in the absence of the other loci, we transferred the Rf-1 region of chromosome 1, between the markers D1Mit34 and D1Rat156, Rf-1B for short, onto the genomic background of the normotensive August x Copenhagen Irish (ACI) rat. In this congenic strain, named ACI.FHH-D1Mit34/Rat156 or ACI.FHH-Rf1B, we challenged the renal hemodynamic function of these animals by studying the effects of unilateral nephrectomy (UNX) alone, or combined with N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Following UNX, the congenic strain developed significantly more UPV and UAV than the ACI progenitor. The differences were even more pronounced when UNX was combined with an L-NAME-induced rise in systolic blood pressure to about 150 mmHg, i.e., the level of hypertension present in the parental FHH strain. These findings indicate that the Rf-1B region of the FHH rat contains at least one gene affecting the susceptibility to progressive renal failure, especially in the presence of an increase in blood pressure.

  1. Phase II antioxidant enzyme activities in brain of male and female ACI rats treated chronically with estradiol.

    PubMed

    Stakhiv, Timothy M; Mesia-Vela, Sonia; Kauffman, Frederick C

    2006-08-09

    Activities of Phase II antioxidant enzymes, including NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotransferase 1A1 (SULT1A1) were measured in brain of August-Copenhagen Irish (ACI) rats exposed chronically to low doses of estradiol (E(2)). ACI rats were selected for study because this strain is highly responsive to treatment with low doses of E(2) as indexed by a high incidence of E(2)-induced mammary tumors compared to other strains. Rats were exposed chronically to 3 mg E(2) contained in cholesterol pellets implanted subcutaneously for 6 weeks. This treatment increased activities of all four enzymes in the striatum of male but not female ACI rats. Blood E(2) levels at time of sacrifice correlated closely with activities of striatal NQO1, GST, and SULT1A1, but not with striatal UGT. NQO1, GST, and SULT1A1 activities in other brain regions including the cortex, cerebellum, and hippocampus were less sensitive to chronic E(2) treatment. NQO1 was primarily localized in vascular elements and neurons and SULT1A1 primarily in neurons and neuropil of control and E(2)-treated rats. Collectively, these results suggest that enhanced expression of NQO1, GST, and SULT1A1 may contribute to the antioxidant effects of E(2) in the striatum, an area of the brain that may be particularly prone to oxidative stress because of its high content of catecholamines.

  2. [Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group "Tissue Regeneration" of the German Society of Orthopaedic Surgery and Traumatology (DGOU)].

    PubMed

    Niemeyer, P; Andereya, S; Angele, P; Ateschrang, A; Aurich, M; Baumann, M; Behrens, P; Bosch, U; Erggelet, C; Fickert, S; Fritz, J; Gebhard, H; Gelse, K; Günther, D; Hoburg, A; Kasten, P; Kolombe, T; Madry, H; Marlovits, S; Meenen, N M; Müller, P E; Nöth, U; Petersen, J P; Pietschmann, M; Richter, W; Rolauffs, B; Rhunau, K; Schewe, B; Steinert, A; Steinwachs, M R; Welsch, G H; Zinser, W; Albrecht, D

    2013-02-01

    Autologous chondrocyte transplantation/implantation (ACT/ACI) is an established and recognised procedure for the treatment of localised full-thickness cartilage defects of the knee. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Traumatology (DGOU) describes the biology and function of healthy articular cartilage, the present state of knowledge concerning potential consequences of primary cartilage lesions and the suitable indication for ACI. Based on current evidence, an indication for ACI is given for symptomatic cartilage defects starting from defect sizes of more than 3-4 cm2; in the case of young and active sports patients at 2.5 cm2. Advanced degenerative joint disease is the single most important contraindication. The review gives a concise overview on important scientific background, the results of clinical studies and discusses advantages and disadvantages of ACI.

  3. Predominant 4-hydroxylation of estradiol by constitutive cytochrome P450s in the female ACI rat liver.

    PubMed

    Wilson, A M; Reed, G A

    2001-02-01

    The ACI rat is extremely sensitive to estrogens as mammary carcinogens, whereas the Sprague-Dawley strain is relatively resistant. Comparison of the disposition and effects of estrogens in these two strains should provide insights into the mechanisms of estrogen carcinogenicity. We have begun this investigation by comparing the metabolism of [(3)H]17beta-estradiol (E2) by liver microsomes prepared from female rats from each strain. Both strains produce estrone (E1) as the major product at E2 concentrations >1 microM, with smaller amounts of 2-hydroxy-E2 formed. As the E2 concentration is decreased, however, aromatic hydroxylation becomes a more dominant pathway for both strains. At starting E2 concentrations as low as 3 nM, Sprague-Dawley liver microsomes produced comparable yields of 2-hydroxy-E2 and E1. In contrast, ACI liver microsomes yielded a profound shift to aromatic hydroxylation as the dominant pathway as E2 concentrations dropped below 1 microM, and this shift reflected the production of 4-hydroxy-E2 as the predominant product. The apparent K(m) for 4-hydroxylation of E2 is <0.8 microM, as opposed to approximately 4 microM for 2-hydroxylation, suggesting that different cytochrome P450s (CYPs) are responsible. Western immunoblotting of the liver microsomal preparations from ACI and Sprague-Dawley rats for CYPs known to catalyze 2- and 4-hydroxylation of E2 revealed that both strains contained comparable amounts of CYP 2B1/2 and 3A1/2, but no detectable amounts of CYP 1B1, the proposed E2 4-hydroxylase. Although this enzyme is not a constitutive CYP in Sprague-Dawley rat liver, its presence in ACI liver could provide a ready explanation for the predominance of 4-hydroxy-E2 as a product. The identity of the estradiol 4-hydroxylase in ACI rat liver and the role of this unique reaction in the heightened sensitivity to E2 carcinogenicity remain to be elucidated.

  4. [Fourcroy and pharmaceutical journals].

    PubMed

    Bonnemain, Bruno

    2011-04-01

    Cadet de Gassicourt wrote a brief Eloge of Fourcroy in January 1810 as he died in December of 1809. Fourcroy had a major role concerning the new ideas on the place of pharmacy at the beginning of the 19th century. Fourcroy has had a key influence for the start of several pharmaceutical journals that wanted to emphasize the link between the new chemistry and pharmacy. None of these journals created with him will survive and one has to wait for 1909 to see the creation, without Fourcroy, of a new pharmaceutical journal, the "Journal de Pharmacie" that will become "Journal de Pharmacie et des Sciences accessoires", then "Journal de Pharmacie et de Chimie", before taking the name of"Annales Pharmaceutiques Françaises", the present official journal of the French Academy of Pharmacy. In spite of the essential role of Fourcroy at the start of pharmaceutical journals, Cadet did not even mention it in his Eloge of 1810.

  5. The first complete genome sequences of the acI lineage, the most abundant freshwater Actinobacteria, obtained by whole-genome-amplification of dilution-to-extinction cultures.

    PubMed

    Kang, Ilnam; Kim, Suhyun; Islam, Md Rashedul; Cho, Jang-Cheon

    2017-02-10

    The acI lineage of the phylum Actinobacteria is the most abundant bacterial group in most freshwater lakes. However, due to difficulties in laboratory cultivation, only two mixed cultures and some incomplete single-amplified or metagenome-derived genomes have been reported for the lineage. Here, we report the initial cultivation and complete genome sequences of four novel strains of the acI lineage from the tribes acI-A1, -A4, -A7, and -C1. The acI strains, initially isolated by dilution-to-extinction culturing, eventually failed to be maintained as axenic cultures. However, the first complete genomes of the acI lineage were successfully obtained from these initial cultures through whole genome amplification applied to more than hundreds of cultured acI cells. The genome sequences exhibited features of genome streamlining and showed that the strains are aerobic chemoheterotrophs sharing central metabolic pathways, with some differences among tribes that may underlie niche diversification within the acI lineage. Actinorhodopsin was found in all strains, but retinal biosynthesis was complete in only A1 and A4 tribes.

  6. The first complete genome sequences of the acI lineage, the most abundant freshwater Actinobacteria, obtained by whole-genome-amplification of dilution-to-extinction cultures

    PubMed Central

    Kang, Ilnam; Kim, Suhyun; Islam, Md. Rashedul; Cho, Jang-Cheon

    2017-01-01

    The acI lineage of the phylum Actinobacteria is the most abundant bacterial group in most freshwater lakes. However, due to difficulties in laboratory cultivation, only two mixed cultures and some incomplete single-amplified or metagenome-derived genomes have been reported for the lineage. Here, we report the initial cultivation and complete genome sequences of four novel strains of the acI lineage from the tribes acI-A1, -A4, -A7, and -C1. The acI strains, initially isolated by dilution-to-extinction culturing, eventually failed to be maintained as axenic cultures. However, the first complete genomes of the acI lineage were successfully obtained from these initial cultures through whole genome amplification applied to more than hundreds of cultured acI cells. The genome sequences exhibited features of genome streamlining and showed that the strains are aerobic chemoheterotrophs sharing central metabolic pathways, with some differences among tribes that may underlie niche diversification within the acI lineage. Actinorhodopsin was found in all strains, but retinal biosynthesis was complete in only A1 and A4 tribes. PMID:28186143

  7. Scientific Journalism in Armenia

    NASA Astrophysics Data System (ADS)

    Farmanyan, S. V.; Mickaelian, A. M.

    2015-07-01

    In the present study, the problems of scientific journalism and activities of Armenian science journalists are presented. Scientific journalism in the world, forms of its activities, Armenian Astronomical Society (ArAS) press-releases and their subjects, ArAS website "Mass Media News" section, annual and monthly calendars of astronomical events, and "Astghagitak" online journal are described. Most interesting astronomical subjects involved in scientific journalism, reasons for non-satisfactory science outreach and possible solutions are discussed.

  8. Curcumin implants, not curcumin diet, inhibit estrogen-induced mammary carcinogenesis in ACI rats.

    PubMed

    Bansal, Shyam S; Kausar, Hina; Vadhanam, Manicka V; Ravoori, Srivani; Pan, Jianmin; Rai, Shesh N; Gupta, Ramesh C

    2014-04-01

    Curcumin is widely known for its antioxidant, anti-inflammatory, and antiproliferative activities in cell-culture studies. However, poor oral bioavailability limited its efficacy in animal and clinical studies. Recently, we developed polymeric curcumin implants that circumvent oral bioavailability issues, and tested their potential against 17β-estradiol (E2)-mediated mammary tumorigenesis. Female Augustus Copenhagen Irish (ACI) rats were administered curcumin either via diet (1,000 ppm) or via polymeric curcumin implants (two 2 cm; 200 mg each; 20% drug load) 4 days before grafting a subcutaneous E2 silastic implant (1.2 cm, 9 mg E2). Curcumin implants were changed after 4.5 months to provide higher curcumin dose at the appearance of palpable tumors. The animals were euthanized after 3 weeks, 3 months, and after the tumor incidence reached >80% (~6 months) in control animals. The curcumin administered via implants resulted in significant reduction in both the tumor multiplicity (2 ± 1 vs. 5 ± 3; P = 0.001) and tumor volume (184 ± 198 mm(3) vs. 280 ± 141 mm(3); P = 0.0283); the dietary curcumin, however, was ineffective. Dietary curcumin increased hepatic CYP1A and CYP1B1 activities without any effect on CYP3A4 activity, whereas curcumin implants increased both CYP1A and CYP3A4 activities but decreased CYP1B1 activity in the presence of E2. Because CYP1A and CYP3A4 metabolize most of the E2 to its noncarcinogenic 2-OH metabolite, and CYP1B1 produces potentially carcinogenic 4-OH metabolite, favorable modulation of these CYPs via systemically delivered curcumin could be one of the potential mechanisms. The analysis of plasma and liver by high-performance liquid chromatography showed substantially higher curcumin levels via implants versus the dietary route despite substantially higher dose administered.

  9. The Journal Synthesizing Activity.

    ERIC Educational Resources Information Center

    Garber, Zev

    The journal synthesizing activity is intended to combine aspects of the formal essay with that of a diary. Activities associated with lecture topics are written up as short journal entries of approximately five typewritten pages and are turned in during the weekly class session at which the related topic is being discussed. The journal project…

  10. Modernizing the journal club.

    PubMed

    Dwarakanath, L S; Khan, K S

    2000-06-01

    Traditionally journal clubs provide a forum to learn presentation skills. We propose a new approach to teaching and learning in journal clubs, focusing on literature acquisition and critical appraisal skills. This approach will enable trainees to use journal clubs for personal professional development as well as for application of new knowledge in clinical medicine to improve patients' outcomes.

  11. How to Rank Journals

    PubMed Central

    Bradshaw, Corey J. A.; Brook, Barry W.

    2016-01-01

    There are now many methods available to assess the relative citation performance of peer-reviewed journals. Regardless of their individual faults and advantages, citation-based metrics are used by researchers to maximize the citation potential of their articles, and by employers to rank academic track records. The absolute value of any particular index is arguably meaningless unless compared to other journals, and different metrics result in divergent rankings. To provide a simple yet more objective way to rank journals within and among disciplines, we developed a κ-resampled composite journal rank incorporating five popular citation indices: Impact Factor, Immediacy Index, Source-Normalized Impact Per Paper, SCImago Journal Rank and Google 5-year h-index; this approach provides an index of relative rank uncertainty. We applied the approach to six sample sets of scientific journals from Ecology (n = 100 journals), Medicine (n = 100), Multidisciplinary (n = 50); Ecology + Multidisciplinary (n = 25), Obstetrics & Gynaecology (n = 25) and Marine Biology & Fisheries (n = 25). We then cross-compared the κ-resampled ranking for the Ecology + Multidisciplinary journal set to the results of a survey of 188 publishing ecologists who were asked to rank the same journals, and found a 0.68–0.84 Spearman’s ρ correlation between the two rankings datasets. Our composite index approach therefore approximates relative journal reputation, at least for that discipline. Agglomerative and divisive clustering and multi-dimensional scaling techniques applied to the Ecology + Multidisciplinary journal set identified specific clusters of similarly ranked journals, with only Nature & Science separating out from the others. When comparing a selection of journals within or among disciplines, we recommend collecting multiple citation-based metrics for a sample of relevant and realistic journals to calculate the composite rankings and their relative uncertainty windows. PMID:26930052

  12. How to Rank Journals.

    PubMed

    Bradshaw, Corey J A; Brook, Barry W

    2016-01-01

    There are now many methods available to assess the relative citation performance of peer-reviewed journals. Regardless of their individual faults and advantages, citation-based metrics are used by researchers to maximize the citation potential of their articles, and by employers to rank academic track records. The absolute value of any particular index is arguably meaningless unless compared to other journals, and different metrics result in divergent rankings. To provide a simple yet more objective way to rank journals within and among disciplines, we developed a κ-resampled composite journal rank incorporating five popular citation indices: Impact Factor, Immediacy Index, Source-Normalized Impact Per Paper, SCImago Journal Rank and Google 5-year h-index; this approach provides an index of relative rank uncertainty. We applied the approach to six sample sets of scientific journals from Ecology (n = 100 journals), Medicine (n = 100), Multidisciplinary (n = 50); Ecology + Multidisciplinary (n = 25), Obstetrics & Gynaecology (n = 25) and Marine Biology & Fisheries (n = 25). We then cross-compared the κ-resampled ranking for the Ecology + Multidisciplinary journal set to the results of a survey of 188 publishing ecologists who were asked to rank the same journals, and found a 0.68-0.84 Spearman's ρ correlation between the two rankings datasets. Our composite index approach therefore approximates relative journal reputation, at least for that discipline. Agglomerative and divisive clustering and multi-dimensional scaling techniques applied to the Ecology + Multidisciplinary journal set identified specific clusters of similarly ranked journals, with only Nature & Science separating out from the others. When comparing a selection of journals within or among disciplines, we recommend collecting multiple citation-based metrics for a sample of relevant and realistic journals to calculate the composite rankings and their relative uncertainty windows.

  13. Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.

    PubMed

    Schaffer, Beverly S; Lachel, Cynthia M; Pennington, Karen L; Murrin, Clare R; Strecker, Tracy E; Tochacek, Martin; Gould, Karen A; Meza, Jane L; McComb, Rodney D; Shull, James D

    2006-08-01

    Exposure to estrogens is associated with an increased risk of breast cancer. Our laboratory has shown that the ACI rat is uniquely susceptible to 17beta-estradiol (E2)-induced mammary cancer. We previously mapped two loci, Emca1 and Emca2 (estrogen-induced mammary cancer), that act independently to determine susceptibility to E2-induced mammary cancer in crosses between the susceptible ACI rat strain and the genetically related, but resistant, Copenhagen (COP) rat strain. In this study, we evaluate susceptibility to E2-induced mammary cancer in a cross between the ACI strain and the unrelated Brown Norway (BN) rat strain. Whereas nearly 100% of the ACI rats developed mammary cancer when treated continuously with E2, BN rats did not develop palpable mammary cancer during the 196-day course of E2 treatment. Susceptibility to E2-induced mammary cancer segregated as a dominant or incompletely dominant trait in a cross between BN females and ACI males. In a population of 251 female (BN x ACI)F(2) rats, we observed evidence for a total of five genetic determinants of susceptibility. Two loci, Emca4 and Emca5, were identified when mammary cancer status at sacrifice was evaluated as the phenotype, and three additional loci, Emca6, Emca7, and Emca8, were identified when mammary cancer number was evaluated as the phenotype. A total of three genetic interactions were identified. These data indicate that susceptibility to E2-induced mammary cancer in the BN x ACI cross behaves as a complex trait controlled by at least five loci and multiple gene-gene interactions.

  14. Promotion of Neurointervention to International Journal Based on Journal Metrics

    PubMed Central

    2016-01-01

    Purpose The aim is to provide evidence of the internationalization of Neurointervention based on journal metrics for articles published from 2011 to 2015. Materials and Methods The following metrics and data were collected and analyzed with descriptive statistics: number of citable and non-citable articles; number of research articles (original papers) supported by grants; editorial board members' countries; authors' countries; citing authors' countries; source title of citing articles; two-year impact factor; total citations; and Hirsch index (h-index). Data were retrieved and analyzed from the journal homepage and Web of Science Core Collection in January 24, 2016. Results There were 80 citable and eight non-citable articles from 2011 to 2015. Out of 31 original articles, nine had research funds (29.0%). Editorial board members are from five countries. The authors are from six countries. The top-ranking countries of citing authors were USA, Korea, and China. The two-year impact factors were 1.125, 0.923, and 0.931 from 2013 to 2015. H-index was 7. Conclusion It was possible to confirm the internationalization of Neurointervention based on journal metrics. New digital standards should be adopted for more rapid dissemination of journal content. PMID:26958406

  15. The Observed On-Orbit Background of the ACIS Instrument of the Chandra X-Ray Observatory

    NASA Technical Reports Server (NTRS)

    Plucinsky, Paul P.; Lavoie, Anthony R. (Technical Monitor)

    2000-01-01

    We have analyzed calibration data acquired during the Orbital Activation and Checkout (OAC) phase of the Chandra X-ray Observatory (CXO) mission in order to characterize the background of the Advanced CCD Imaging Spectrometer (ACIS) produced by charged particles and non-cosmic x-rays. The ACIS instrument contains eight Front-Illuminated (FI) CCDs and two Back-Illuminated (BI) CCDs. The FI and BI CCDs exhibit dramatically different responses to enhancements in the particle flux. The FI CCDs show relatively little increase in the overall count rate, typical increases are 1-3 counts/s; the BI CCDs show large excursions to as high as 100 counts/s. The directions of these intervals of enhanced background are highly variable ranging from 100 s to 5000 s. The spatial distribution of these background events is relatively flat across the detectors. The spectral distribution can be characterized by a simple power law. The events produce morphologies which are similar to cosmic x-ray events, so that morphology alone cannot be used as a rejection criterion. We explore the correlation of these times of high background with the data from Chandra's on-board radiation monitor, the EPHIN (Electron, Proton, Helium Instrument particle detector) instrument and archival data from the Advanced Composition Explorer (ACE) satellite. We discuss strategies for observers to identify and exclude times of high background and to model and subtract the background events from their data.

  16. Journal of Undergraduate Research, Volume VI, 2006

    SciTech Connect

    Faletra, P.; Schuetz, A.; Cherkerzian, D.; Clark, T.

    2006-01-01

    Students who conducted research at DOE National Laboratories during 2005 were invited to include their research abstracts, and for a select few, their completed research papers in this Journal. This Journal is direct evidence of students collaborating with their mentors. Fields in which these students worked include: Biology; Chemistry; Computer Science; Engineering; Environmental Science; General Sciences; Materials Sciences; Medical and Health Sciences; Nuclear Sciences; Physics; and Science Policy.

  17. Whither Electronic Journals?

    ERIC Educational Resources Information Center

    Luther, Judy

    2000-01-01

    Discusses Web-based electronic journals for the academic market and presents a chart that includes sources of electronic journals and value added. Considers trends in collections, including remote access, outsourcing, hosting content versus linking, and subject portals; trends in access, including indexing, backfiles, and database usage; and…

  18. Journals and Program Assessment

    ERIC Educational Resources Information Center

    Cluphf, David J.; Lox, Curt L.

    2009-01-01

    The purpose of this study was to use journal feedback from student teachers to understand and document how well the Physical Education-Teacher Education (PETE) program prepares teacher candidates in relation to the three primary goals of the PETE program. Analysis of the journals revealed areas of merit and concern for the PETE faculty. The most…

  19. Rewriting the Journal

    ERIC Educational Resources Information Center

    Fredette, Michelle

    2012-01-01

    With faculty balking at the price of academic journals, can other digital publishing options get traction? University libraries are no strangers to one of the most popular online alternatives, the open-access archive. These archives enable scholars to upload work--including drafts of articles that are published later in subscription journals--so…

  20. The Journal Book.

    ERIC Educational Resources Information Center

    Fulwiler, Toby, Ed.

    Essays on the use of journal writing in the classroom are presented in four sections: the language of speculation, journals in the teaching of English, the arts and humanities, and the quantitative disciplines. Titles and authors are as follows: (1) "Dialectical Notebooks and the Audit of Meaning" (A. E. Berthoff); (2) "Desert…

  1. YALA Journal, 1990.

    ERIC Educational Resources Information Center

    YALA Journal, 1990

    1990-01-01

    The YALA journal is an annual publication of the Young Adult Learning Academy (YALA) in New York City, New York. This journal, one of many YALA publications and projects, was designed to encourage students to assume active roles in their education and to present their ideas, feelings, and craft to others. The YALA was established in 1984 to…

  2. Electronic Journalism: More Fear?

    ERIC Educational Resources Information Center

    Terry, Carolyn

    2002-01-01

    Considers how the same First Amendment protections that govern print journalism apply to electronic practitioners. Discusses how the number of broadcast and online journalism classes at the nation's high schools demonstrate steady growth, according to a survey conducted in the fall of 2001 for the Radio and Television News Directors Foundation.…

  3. Writing for Education Journals.

    ERIC Educational Resources Information Center

    Henson, Kenneth T.

    1990-01-01

    Based on questionnaires sent to education journal editors, this article explains the intricacies of writing for publication. Practical information is provided concerning rejection rates, the nature of refereed journals, the necessity of targeting articles to meet editorial specifications and particular audiences, and manuscript preparation. (MLH)

  4. Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross.

    PubMed

    Shull, James D; Lachel, Cynthia M; Murrin, Clare R; Pennington, Karen L; Schaffer, Beverly S; Strecker, Tracy E; Gould, Karen A

    2007-09-01

    Estrogens are important regulators of growth and development and contribute to the etiology of several types of cancer. Different inbred rat strains exhibit marked, cell-type-specific differences in responsiveness to estrogens as well as differences in susceptibility to estrogen-induced tumorigenesis. Regulation of pituitary lactotroph homeostasis is one estrogen-regulated response that differs dramatically between different inbred rat strains. In this article we demonstrate that the growth response of the anterior pituitary gland of female ACI rats to 17beta-estradiol (E2) markedly exceeds that of identically treated female Brown Norway (BN) rats. We further demonstrate that pituitary mass, a surrogate indicator of absolute lactotroph number, behaves as a quantitative trait in E2-treated F(2) progeny generated in a genetic cross originating with BN females and ACI males. Composite interval mapping analyses of the (BNxACI)F(2) population revealed quantitative trait loci (QTLs) that exert significant effects on E2-induced pituitary growth on rat chromosome 4 (RNO4) (Ept5) and RNO7 (Ept7). Continuous treatment with E2 rapidly induces mammary cancer in female ACI rats but not BN rats, and QTLs that impact susceptibility to E2-induced mammary cancer in the (BNxACI)F(2) population described here have been mapped to RNO3 (Emca5), RNO4 (Emca6), RNO5 (Emca8), RNO6 (Emca7), and RNO7 (Emca4). Ept5 and Emca6 map to distinct regions of RNO4. However, Ept7 and Emca4 map to the same region of RNO7. No correlation between pituitary mass and mammary cancer number at necropsy was observed within the (BNxACI)F(2) population. This observation, together with the QTL mapping data, indicate that with the exception of the Ept7/Emca4 locus on RNO7, the genetic determinants of E2-induced pituitary growth differ from the genetic determinants of susceptibility to E2-induced mammary cancer.

  5. Optimizing journal bearing bit performance

    SciTech Connect

    Moerbe, O.E.; Evans, W.

    1986-10-01

    This article explains that continuous progress in the field of rock bit technology has produced many new designs and improved features in the tri-cone rock bits used today. Much of the research and advancements have centered around journal bearing systems, seals and lubricants leading to greatly extended bearing life. These improved bearing systems, incorporated into both tooth and insert-type bits, have not only increased the effective life of a rock bit, but have also allowed greater energy levels to be applied. This, in turn, has allowed for higher rates of penetration and lower costs per foot of hole drilled. Continuous improvements in journal bearing bits allowing them to run longer and harder have required similar advancements to be made in cutting structures. In tooth bit designs, these improvements have been basically limited to the areas of gauge protection and to application of hardfacing materials.

  6. Uses and Benefits of Journal Writing.

    ERIC Educational Resources Information Center

    Hiemstra, Roger

    2001-01-01

    Describes various types of journals: learning journals, diaries, dream logs, autobiographies, spiritual journals, professional journals, interactive reading logs, theory logs, and electronic journals. Lists benefits of journal writing and ways to overcome writing blocks. (Contains 19 references.) (SK)

  7. The Cost of Journals

    NASA Astrophysics Data System (ADS)

    Moore, John W.

    1997-08-01

    On page 896 we announce appointment of a new Publications Coordinator for the Journal, Richard Schwenz of the University of Northern Colorado. After five years of yeoman service, Ken Emerson of Montana State University, is retiring. Ken has seen the Journal through a lot of change: a new editor, a new advertising representative, a new subscription fulfillment agent, and a consolidation of the Journal's print, software, and online operations. All this has taken a lot of work and intelligence, and the entire editorial staff thanks Ken for all of his efforts on our behalf.

  8. Hydrogeology Journal in 2004

    USGS Publications Warehouse

    Voss, Clifford; Olcott, Perry; Schneider, Robert; Watson, Christine

    2004-01-01

    Hydrogeology Journal continues to flourish. The increase in the size of our yearly volume attests to the success and growing international reputation of the journal. Until 2001, HJ produced about 600 printed pages each year. This number has steadily increased, and in 2005 and 2006, HJ will be allocated 800 pages per year by the publisher. Despite this good news, the journal is having some growing pains. Most pages in next year’s issues are already fully allocated with currently accepted articles and therefore, many accepted articles must now wait up to one year to appear in printed form. Clearly, this is not an acceptable situation for authors or readers.

  9. The Apollo 17 Lunar Surface Journal

    SciTech Connect

    Jones, E.M.

    1995-08-01

    The material included in the Apollo 17 Lunar Surface Journal has been assembled so that an uninitiated reader can understand, in some detail, what happened during Apollo 17 and why and what was learned, particularly about living and working on the Moon. At its heart, the Journal consists a corrected mission transcript which is interwoven with commentary by the crew and by Journal Editor -- commentary which, we hope, will make the rich detail of Apollo 17 accessible to a wide audience. To make the Journal even more accessible, this CD-ROM publication contains virtually all of the Apollo 17 audio, a significant fraction of the photographs and a selection of drawings, maps, video clips, and background documents.

  10. Diallyl sulfide induces the expression of nucleotide excision repair enzymes in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) causes DNA adducts resulting in breast cancer, whereas diallyl sulfide (DAS) inhibits cancer formation. We hypothesize that DAS induces the expression of nucleotide excision repair genes. To test this hypothesis, female ACI rats were treated for 4 days with corn oil, DES, DAS, and DAS/DES (50mg/kg). The expression of P53, Gadd45a, PCNA, and DNA polymerase delta was analyzed by real-time PCR. DES decreased the expression of P53, Gadd45a and PCNA. DAS and DAS/DES increased the expression of all four genes. These results suggest that DAS enhances the ability of breast tissue to repair DNA damage thus preventing cancer.

  11. Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats.

    PubMed

    Mense, Sarah M; Singh, Bhupendra; Remotti, Fabrizio; Liu, Xinhua; Bhat, Hari K

    2009-07-01

    The mechanisms underlying the pathogenesis of estrogen-induced breast carcinogenesis remain unclear. The present study investigated the roles of estrogen metabolism and oxidative stress in estrogen-mediated mammary carcinogenesis in vivo. Female August Copenhagen Irish (ACI) rats were treated with 17beta-estradiol (E(2)), the antioxidant vitamin C, the estrogen metabolic inhibitor alpha-naphthoflavone (ANF), or cotreated with E(2) + vitamin C or E(2) + ANF for up to 8 months. E(2) (3 mg) was administered as an subcutaneous implant, ANF was given via diet (0.2%) and vitamin C (1%) was added to drinking water. At necropsy, breast tumor incidence in the E(2), E(2) + vitamin C and E(2) + ANF groups was 82, 29 and 0%, respectively. Vitamin C and ANF attenuated E(2)-induced alterations in oxidative stress markers in breast tissue, including 8-iso-prostane F(2alpha) formation and changes in the activities of antioxidant enzymes superoxide dismutase and glutathione peroxidase. Quantification of 2-hydroxyestradiol (2-OHE(2)) and 4-hydroxyestradiol (4-OHE(2)) formation in breast tissue confirmed that ANF inhibited 4-hydroxylation of E(2) and decreased formation of the highly carcinogenic 4-OHE(2). These results demonstrate that antioxidant vitamin C reduces the incidence of estrogen-induced mammary tumors, increases tumor latency and decreases oxidative stress in vivo. Further, our data indicate that ANF completely abrogates breast cancer development in ACI rats. The present study is the first to demonstrate the inhibition of breast carcinogenesis by antioxidant vitamin C or the estrogen metabolic inhibitor ANF in an animal model of estrogen-induced mammary carcinogenesis. Taken together, these results suggest that E(2) metabolism and oxidant stress are critically involved in estrogen-induced breast carcinogenesis.

  12. The evolution of the ACIS contamination layer over the 16-year mission of the Chandra X-ray Observatory

    NASA Astrophysics Data System (ADS)

    Plucinsky, Paul P.; Bogdan, Akos; Germain, Gregg; Marshall, Herman L.

    2016-07-01

    The Chandra X-ray Observatory (CXO) was launched 16 years ago and has been delivering spectacular science over the course of its mission. The Advanced CCD Imager Spectrometer (ACIS) is the prime instrument on the satellite, conducting over 90% of the observations. The CCDs operate at a temperature of -120 C and the optical blocking filter (OBF) in front of the CCDs is at a temperature of approximately -60 C. The surface of the OBF has accumulated a layer of contamination over the course of the mission, as it is the coldest surface exposed to the interior to the spacecraft. We have been characterizing the thickness, chemical composition, and spatial distribution of the contamination layer as a function of time over the mission. All three have exhibited significant changes with time. The calibration team within the Chandra X-ray Center (CXC) generates calibration files that describe the additional absorption produced by the contamination layer as a function of time, position, and energy. We have verified the accuracy of this contamination file for the on-axis aimpoints using the standard model spectrum for the Supernova Remnant 1E 0102.2-7219 in the Small Magellanic Cloud developed by the International Consortium for High Energy Calibration (IACHEC), but we show the model is less accurate for the off-axis positions after 2013. In 2015, the ACIS Detector Housing heater was turned on to increase the temperature of the OBF in the hope that the accumulation rate of the contamination layer would decrease. We show that the accumulation rate of the contaminant is unchanged since the DH heater was turned on.

  13. Journaling: Astronauts Chronicle Missions

    NASA Video Gallery

    Journaling has and will always play an important role in any journey. It’s a simple yet invaluable tool used by behavioral scientists to help assess the mental and emotional states associated with ...

  14. In Other Professional Journals.

    ERIC Educational Resources Information Center

    Campbell, Christine M.

    1992-01-01

    Lists current articles, appearing in major journals on language teaching and learning, applied psycholinguistics, linguistics, curriculum development, computer science, psychology, educational technology, and general education, of particular interest to foreign language instruction professionals. (CB)

  15. Gold/copper-catalyzed activation of the aci-form of nitromethane in the synthesis of methylene-bridged bis-1,3-dicarbonyl compounds.

    PubMed

    Balamurugan, Rengarajan; Manojveer, Seetharaman

    2011-10-21

    Activation of the aci-form of nitromethane using Lewis acids for the attack of carbon nucleophiles was studied. 1,3-Dicarbonyl compounds in the presence of catalytic amounts of AuCl(3) or Cu(OTf)(2) in nitromethane solvent could be converted into methylene-bridged bis-1,3-dicarbonyl compounds.

  16. Citation Indicators of Japanese Journals.

    ERIC Educational Resources Information Center

    Haiqi, Zhang; Yamazaki, Shigeaki

    1998-01-01

    Evaluates Japanese journals--128 indexed in the 1994 "Journal Citation Reports"--in bibliometric parameters such as impact factors (IFs), mean IFs from citing and cited journals, and self-citing and self-cited rates. Results: only 15 journals, with a wide variation of self-citing and self-cited rates, have obtained a current impact…

  17. Performance of Malaysian Medical Journals.

    PubMed

    Abrizah, Abdullah

    2016-03-01

    Indexation status matters for scholarly journal prestige and trust. The performance of Malaysian medical journals at the international level is gauged through the global citation databases, and at the national level through MyCite, a national citation indexing system. The performance indicators include journals publication productivity, the citations they garner, and their scores on other bibliometric indices such as journal impact factor (IF), and h-index. There is a growing consciousness amongst journal editorials to improve quality and increase chances of getting indexed in MyCite. Although it is now possible to gauge journal performance within Malaysia, through MyCite, the government and public are concerned about journal performance in international databases. Knowing the performance of journals in MyCite will help the editors and publishers to improve the quality and visibility of Malaysian journals and strategise to bring their journal to the international level of indexation.

  18. Performance of Malaysian Medical Journals

    PubMed Central

    Abrizah, Abdullah

    2016-01-01

    Indexation status matters for scholarly journal prestige and trust. The performance of Malaysian medical journals at the international level is gauged through the global citation databases, and at the national level through MyCite, a national citation indexing system. The performance indicators include journals publication productivity, the citations they garner, and their scores on other bibliometric indices such as journal impact factor (IF), and h-index. There is a growing consciousness amongst journal editorials to improve quality and increase chances of getting indexed in MyCite. Although it is now possible to gauge journal performance within Malaysia, through MyCite, the government and public are concerned about journal performance in international databases. Knowing the performance of journals in MyCite will help the editors and publishers to improve the quality and visibility of Malaysian journals and strategise to bring their journal to the international level of indexation. PMID:27547108

  19. Significant journals of science.

    PubMed

    Garfield, E

    1976-12-16

    In 1974 the Science Citation Index (SCI) covered about 401,000 articles and communications in 2,443 scientific and technical journals. They cited about 3.2 million different publications an average of 1.8 times each. In this article some results of an analysis of more than 5 million citations in the references of journal articles indexed for the SCI in 1974 are presented and an attempt is made to interpret of those results in the light of an earlier study of 1969 citations.

  20. Targeting the right journal.

    PubMed

    Piterman, L; McCall, L

    1999-07-01

    While research is scientific, publication is a mixture of science and political pragmatism. Targeting the right journal is influenced by the following factors: the discipline that best represents the subject; the purpose of the message; the audience who are to be recipients of the message; the realities of geographic parochialism; the desire of authors to maximise personal and professional opportunities. If the originally targeted journal rejects the article, authors should have alternative publication strategies that give them professional recognition without requiring them to compromise the message or their ethics.

  1. English Teachers' Journal (Israel), Number 29.

    ERIC Educational Resources Information Center

    English Teachers' Journal (Israel), 1984

    1984-01-01

    This journal includes current information for English teachers (new publications, resource materials, textbooks, tests, and trends) and these articles: "Reliability in the Oral Bagrut Test" (Raphael Gefen); "A Methodological Approach to 'Rewrite Sentence' Drills" (Eliyahu Galore); "Translation as a Bagrut Subject"…

  2. Journal of Undergraduate Research, Volume VIII, 2008

    SciTech Connect

    Stiner, K. S.; Graham, S.; Khan, M.; Dilks, J.; Mayer, D.

    2008-01-01

    Th e Journal of Undergraduate Research (JUR) provides undergraduate interns the opportunity to publish their scientific innovation and to share their passion for education and research with fellow students and scientists. Fields in which these students worked include: Biology; Chemistry; Computer Science; Engineering; Environmental Science; General Sciences; Materials Sciences; Medical and Health Sciences; Nuclear Sciences; Physics; Science Policy; and Waste Management.

  3. NUMMO, A Black Theatre Journal, Summer, 1978.

    ERIC Educational Resources Information Center

    Morrison, Carl F., Jr., Ed.

    The entries in this journal represent the second annual publication of selected material dealing with the topic of black theatre. Articles describe an evening with the Frank Silvera Writers Workshop in Harlem, relate an interview with Vinie Burrows, explore the thinking of black scholars and artists on the elements of the African-American theatre…

  4. The Role of Microforms in Journal Publication

    ERIC Educational Resources Information Center

    Kuney, J. H.

    1972-01-01

    The need for increased use of microfilm in primary publications is discussed. The microfilm editions of the American Chemical Society journals are now being used for supplementary material of restricted interest. Details of this arrangement and experience to date are presented. (4 references) (Author)

  5. List of Core Journals in Earth Sciences.

    ERIC Educational Resources Information Center

    International Council for Scientific and Technical Information, Paris (France).

    Selection and acquisition of relevant materials for building and developing an information infrastructure are modern worldwide problems. This document provides a core listing of journals in the earth sciences in an effort to develop a tool for the improvement of information handling and transfer. The core list was generated using several databases…

  6. The use of portable equipment for the activity concentration index determination of building materials: method validation and survey of building materials on the Belgian market.

    PubMed

    Stals, M; Verhoeven, S; Bruggeman, M; Pellens, V; Schroeyers, W; Schreurs, S

    2014-01-01

    The Euratom BSS requires that in the near future (2015) the building materials for application in dwellings or buildings such as offices or workshops are screened for NORM nuclides. The screening tool is the activity concentration index (ACI). Therefore it is expected that a large number of building materials will be screened for NORM and thus require ACI determination. Nowadays, the proposed standard for determination of building material ACI is a laboratory analyses technique with high purity germanium spectrometry and 21 days equilibrium delay. In this paper, the B-NORM method for determination of building material ACI is assessed as a faster method that can be performed on-site, alternative to the aforementioned standard method. The B-NORM method utilizes a LaBr3(Ce) scintillation probe to obtain the spectral data. Commercially available software was applied to comprehensively take into account the factors determining the counting efficiency. The ACI was determined by interpreting the gamma spectrum from (226)Ra and its progeny; (232)Th progeny and (40)K. In order to assess the accuracy of the B-NORM method, a large selection of samples was analyzed by a certified laboratory and the results were compared with the B-NORM results. The results obtained with the B-NORM method were in good correlation with the results obtained by the certified laboratory, indicating that the B-NORM method is an appropriate screening method to assess building material ACI. The B-NORM method was applied to analyze more than 120 building materials on the Belgian market. No building materials that exceed the proposed reference level of 1 mSv/year were encountered.

  7. The Metacognitive Reading Journal: A Tool for Teacher Change.

    ERIC Educational Resources Information Center

    Maria, Katherine

    Teachers enrolled in a graduate reading course on the latest research in comprehension and instructional techniques were asked to keep a metacognitive journal instead of writing a traditional term paper. The journal provided the 32 teachers with the opportunity to become aware of the strategies that they use in processing difficult material,…

  8. The Use of Student Journals in Teaching Psychology.

    ERIC Educational Resources Information Center

    Harris, Richard J.

    The use of student journals in teaching introductory psychology was investigated at Kansas State University. Students in both a small honors class and a large general psychology lecture were asked to keep a journal with at least one entry weekly. While they were encouraged to relate course material to their own lives, nothing was restricted. The…

  9. "It's Just a Nuisance": Improving College Student Reflective Journal Writing

    ERIC Educational Resources Information Center

    Mills, Roxanne

    2008-01-01

    While many educators call for having students use reflective journaling in the classroom as both a way of getting students to engage in content matter and as a way to help the students find some level of personal connection to content material, research shows that many students see reflective journaling as merely busy work and, consequently, fail…

  10. Diversity and Journalism Pedagogy: Exploring News Media Representation of Disability

    ERIC Educational Resources Information Center

    Burns, Shawn

    2016-01-01

    This essay explores disability studies in broadcast journalism education and seeks to help answer a question faced by teachers: Does the material discussed in class make a difference in their lives, including how they approach their work? This essay draws on a case study of university broadcast journalism students who took part in classes that…

  11. Using the Technique of Journal Writing to Learn Emergency Psychiatry

    ERIC Educational Resources Information Center

    Bhuvaneswar, Chaya; Stern, Theodore; Beresin, Eugene

    2009-01-01

    Objective: The authors discuss journal writing in learning emergency psychiatry. Methods: The journal of a psychiatry intern rotating through an emergency department is used as sample material for analysis that could take place in supervision or a resident support group. A range of articles are reviewed that illuminate the relevance of journal…

  12. A Chandra/ACIS & HST/STIS Study of Well Resolved Outflow/ISM Interactions in NGC 3079 & NGC 1068

    NASA Astrophysics Data System (ADS)

    Cecil, G.; Veilleux, S.; Groves, B.; Dopita, M.

    2002-05-01

    Flows in both galaxies reach 2000 km/s wrt galaxy rest several arcsecs outside the nucleus. WFPC2 images (Cecil et al 2001, ApJ, 555, 338) resolved the 12\\arcsec (1.2 kpc) diameter nuclear superbubble of NGC 3079 into 4 narrow, twisted towers of optical-line emitting filaments; we also posited a spatially extended nuclear jet. We report here our analysis of a recently archived exposure made with ACIS/Chandra. The nucleus shows the Fe complex, arguing for an AGN power source rather than starburst. We find that at 1\\farcs5 FWHM resolution, X-rays coincide within +/-0\\farcs5 with the towers of optical filaments. The counterbubble visible in radio but obscured by the galaxy disk is also detected at its base in X-rays. The optical filament towers start at the galaxy disk and are known to be rising at large space velocity, so are not overrun halo clouds. The tight correlation between optical line- and X-ray emissions suggests that X-rays either form at the cooling interface with shocked wind, or are standoff bow shocks upstream of disk ejecta in an otherwise unimpeded wind. A proposed longer ACIS exposure with twofold better angular resolution would distinguish between these scenarios, and would provide spectra to further constrain the dynamics of the X-ray gas. For NGC 1068, we present our analysis of several parallel STIS NUV+FUV spectra that span the radio jet and spatially compact yet broadline (2500 km/s) line-emitting knots adjacent to the NLR cloud complexes (Cecil et al 2002, ApJ, April 1). We correlate variations in UV line fluxes with filament kinematics mapped with STIS [O III]+Hβ line profiles as well as by spectra taken during science verification of the integral-field unit (IFU) on the Gemini-N Multi-Object Spectrometer (GMOS) (0\\farcs48 FWHM). The IFU spectra show the great potential for studies with large telescopes of fainter but critical diagnostic lines across spatially complex flows. This work is supported by NASA GTO grants.

  13. Chandra ACIS Survey of X-ray Point Sources in 383 Nearby Galaxies. I. The Source Catalog

    NASA Astrophysics Data System (ADS)

    Liu, Jifeng

    2011-01-01

    The Chandra data archive is a treasure for various studies, and in this paper we exploit this valuable resource to study the X-ray point source populations in nearby galaxies. By 2007 December 14, 383 galaxies within 40 Mpc with isophotal major axis above 1 arcmin had been observed by 626 public ACIS observations, most of which were for the first time analyzed by this survey to study the X-ray point sources. Uniform data analysis procedures are applied to the 626 ACIS observations and lead to the detection of 28,099 point sources, which belong to 17,599 independent sources. These include 8700 sources observed twice or more and 1000 sources observed 10 times or more, providing us a wealth of data to study the long-term variability of these X-ray sources. Cross-correlation of these sources with galaxy isophotes led to 8519 sources within the D25 isophotes of 351 galaxies, 3305 sources between the D25 and 2D25 isophotes of 309 galaxies, and additionally 5735 sources outside 2D25 isophotes of galaxies. This survey has produced a uniform catalog, by far the largest, of 11,824 X-ray point sources within 2D25 isophotes of 380 galaxies. Contamination analysis using the log N-log S relation shows that 74% of sources within 2D25 isophotes above 1039 erg s-1, 71% of sources above 1038 erg s-1, 63% of sources above 1037 erg s-1, and 56% of all sources are truly associated with galaxies. Meticulous efforts have identified 234 X-ray sources with galactic nuclei of nearby galaxies. This archival survey leads to 300 ultraluminous X-ray sources (ULXs) with LX (0.3-8 keV) >= 2 × 1039 erg s-1within D25 isophotes, 179 ULXs between D25 and 2D25 isophotes, and a total of 479 ULXs within 188 host galaxies, with about 324 ULXs truly associated with host galaxies based on the contamination analysis. About 4% of the sources exhibited at least one supersoft phase, and 70 sources are classified as ultraluminous supersoft sources with LX (0.3-8 keV) >= 2 × 1038 erg s-1. With a uniform data

  14. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats.

    PubMed

    Weroha, S John; Li, Sara Antonia; Tawfik, Ossama; Li, Jonathan J

    2006-03-01

    A common feature of human breast oncogenesis is cell cycle deregulation. The expression of cyclins D1 and D3 was examined during estradiol-17beta (E(2))-induced mammary tumorigenesis in female August Copenhagen Irish (ACI) rats. Low serum E(2) levels ( approximately 60-120 pg/ml) were sufficient to induce mammary gland tumors (MGTs) that remarkably resemble human ductal breast cancer (BC) at the histopathologic and molecular levels. Western blot analysis of the E(2)-induced MGTs revealed a marked rise in cyclins D1 (24-fold), D3 (9-fold) and cdk4 (3-fold) expression compared with age-matched untreated controls. Small focal dysplasias with large, pale staining nuclei were commonly seen at 3-3.6 months, large focal dysplasias, including atypical ductal hyperplasia at 3.6-4.3 months, ductal carcinoma in-situ (DCISs) at 4.3-5.0 months, and 100% incidence of invasive ductal BC/frank tumors at 5-6 months were detected after E(2) treatment. Immunohistochemical analysis of serial sections of focal dysplasias, DCISs and invasive ductal carcinomas showed overexpression of cyclins D1, D3, estrogen receptor-alpha (ERalpha) and progesterone receptor (PR). However, cyclin D3 expression, unlike D1, was confined essentially to early pre-malignant lesions (focal dysplasias and DCISs) and primary MGTs with <1-5% of resting and normal hyperplastic breast cells staining positive. The kinase activity for cyclins D1 and D3, using retinoblastoma (Rb) as a substrate, in E(2)-induced MGTs and their binding to cdk4 was significantly elevated. Semi-quantitative reverse transcriptase PCR analysis of the E(2)-induced MGTs exhibited increased expression of cyclins D1 (2.9-fold) and D3 (1.4-fold) mRNA, indicating that their elevated protein expression was due in part to an increase in mRNA transcription. However, when analyzed by quantitative real-time Q-PCR, these genes were not amplified. These data indicate that in female ACI rat mammary glands, E(2)-induced pre-malignant lesions

  15. Comparison of SCImago journal rank indicator with journal impact factor.

    PubMed

    Falagas, Matthew E; Kouranos, Vasilios D; Arencibia-Jorge, Ricardo; Karageorgopoulos, Drosos E

    2008-08-01

    The application of currently available sophisticated algorithms of citation analysis allows for the incorporation of the "quality" of citations in the evaluation of scientific journals. We sought to compare the newly introduced SCImago journal rank (SJR) indicator with the journal impact factor (IF). We retrieved relevant information from the official Web sites hosting the above indices and their source databases. The SJR indicator is an open-access resource, while the journal IF requires paid subscription. The SJR indicator (based on Scopus data) lists considerably more journal titles published in a wider variety of countries and languages, than the journal IF (based on Web of Science data). Both indices divide citations to a journal by articles of the journal, during a specific time period. However, contrary to the journal IF, the SJR indicator attributes different weight to citations depending on the "prestige" of the citing journal without the influence of journal self-citations; prestige is estimated with the application of the PageRank algorithm in the network of journals. In addition, the SJR indicator includes the total number of documents of a journal in the denominator of the relevant calculation, whereas the journal IF includes only "citable" articles (mainly original articles and reviews). A 3-yr period is analyzed in both indices but with the use of different approaches. Regarding the top 100 journals in the 2006 journal IF ranking order, the median absolute change in their ranking position with the use of the SJR indicator is 32 (1st quartile: 12; 3rd quartile: 75). Although further validation is warranted, the novel SJR indicator poses as a serious alternative to the well-established journal IF, mainly due to its open-access nature, larger source database, and assessment of the quality of citations.

  16. Writing & Drawing in the Naturalist's Journal: Reviving the Tradition of the Naturalist's Journal as an Effective Learning Tool

    ERIC Educational Resources Information Center

    Dirnberger, Joseph M.; McCullagh, Steven; Howick, Tom

    2005-01-01

    The naturalist's journal is a collection of writings and sketches that captures selected thoughts or observations of nature and represents both immediate learning and raw material that is available for more polished work. This article talks about a naturalist's journal as an effective teaching and learning tool. Creating a naturalist's journals…

  17. The CATESOL Journal, 2001.

    ERIC Educational Resources Information Center

    Brinton, Donna, Ed.; Ching, Roberta, Ed.

    2001-01-01

    This journal contains the following articles: "Teachers' Perceptions of the Supports and Resources Needed to Prepare English Language Learners for the Future" (Douglas Fisher); "Exploring the Learning Styles of Russian-Speaking Students of English as a Second Language" (Ann C. Wintergerst and Andrea DeCapua); "New Voices…

  18. Brazilian History through Journalism.

    ERIC Educational Resources Information Center

    Zaher, Celia Ribeiro; Varella, Maria Angelica

    This paper provides an overview of the beginnings of the newspaper in Brazil with information on the more significant titles and their role in the history of journalism and their impact on social change that occurred between the Imperial and Republican periods. Current collections at the National Library and legal deposit are discussed. It…

  19. JALT Journal, 2002.

    ERIC Educational Resources Information Center

    Jungheim, Nicholas O., Ed.

    2002-01-01

    These two journal issues include the following articles: "Assistant Foreign Language Teachers in Japanese High Schools: Focus on the Hosting of Japanese Teachers" (Great Gorsuch); "Communicative Language Teaching (Organizational Effectiveness of Upper Secondary School English Language Departments and Their Commitment toward…

  20. Recruiting Blacks into Journalism.

    ERIC Educational Resources Information Center

    Tipton, Leonard; And Others

    Despite significant progress in the recruitment of black journalists, adequate representation of blacks in newsrooms remains an acute concern. The results of (1) statistical monitoring by organizations such as the Newspaper Fund, (2) searching of trade press and academic journal articles for insights into the problem, (3) an open-ended…

  1. JALT Journal, 2001.

    ERIC Educational Resources Information Center

    Fotos, Sandra, Ed.; Jungheim, Nicholas O., Ed.

    2001-01-01

    The two issues in this volume of the "JALT Journal" contain the following articles: "Comprehension and Production Practice in Grammar Instruction: Does Their Combined Use Facilitate Second Language Acquisition?" (Takeo Tanaka); "Professional Development and the JET Program: Insights and Solutions Based on the Sendai City…

  2. Framing Journalism Education

    ERIC Educational Resources Information Center

    Abusharif, Ibrahim N.

    2014-01-01

    Examining the growth, incentives, and progress of overseas campuses of major American educational institutions is an important academic pursuit. To have a complete picture, one must also consider the impact these branch campuses are having on the lives of their students. The Northwestern University in Qatar's journalism program was invited to…

  3. Pedagogy Journal, 2000.

    ERIC Educational Resources Information Center

    Marashio, Nancy, Ed.; Marashio, Paul, Ed.

    2000-01-01

    The theme of the 2000 issue of Pedagogy Journal is finding a "sense of place" within the higher education community. Articles contained discuss this issue as it pertains to different aspects of the postsecondary system. These articles include: (1) "The Role of Left-Brain/Right-Brain Learning Theory in Personal Computer Courses" (Jack Wakelin); (2)…

  4. Launching Family Message Journals.

    ERIC Educational Resources Information Center

    Wollman-Bonilla, Julie

    This lesson introduces Family Message Journals, a tool for encouraging family involvement and supporting writing to reflect and learn. First and second graders are led into composing through demonstration, guided writing, and finally independent writing of messages that they will bring home for family to read and write a reply. During the three…

  5. Writing Journals: An Investigation.

    ERIC Educational Resources Information Center

    Graham, Lynda

    2003-01-01

    Describes a small action research project currently being undertaken by a group of primary teachers and an LEA (Local Education Authority) professional development consultant for English. Explores ways in which the introduction of writing journals enhances children's confidence and competence as writers. Concludes that it seems worth looking…

  6. Library Journal Classics.

    ERIC Educational Resources Information Center

    Berninghausen, David; And Others

    1993-01-01

    Provides excerpts from David Berninghausens's "Social Responsibility vs. the Library Bill of Rights" and responses that appeared in "Library Journal" in 1972 and 1973 because of the continuing debate over the role of the American Library Association (ALA) Social Responsibilities Round Table and whether or not ALA should take…

  7. Social Studies Journal, 2003.

    ERIC Educational Resources Information Center

    West, Leo R., Ed.

    2003-01-01

    This theme issue of the "Social Studies Journal" focuses on the worldwide conflict known in the United States as the French and Indian War (1754-1763). The volume is dedicated to examining the conflict in Pennsylvania. Western Pennsylvania became a battle-scarred landscape as the British and French, with their Native American allies,…

  8. Parent's Journal. [Videotape Series].

    ERIC Educational Resources Information Center

    1999

    Parent's Journal is a set of 16 videotapes for parents of prenatal, infant, and toddler-age children, created by the Alaska Native Home Base Video Project of the Tlingit and Haida Head Start Program. This series offers culturally relevant solutions to the challenges of parenting, drawing on the life stories and experiences of capable mothers and…

  9. CACD Journal, 2001.

    ERIC Educational Resources Information Center

    Wickwire, Pat Nellor, Ed.

    2001-01-01

    This journal of the California Association for Counseling and Development attempts to identify the current issues of concern in the counseling field and share research to help improve the professional learning community. The articles in this issue include: "The Editor's Message" (Pat Nellor Wickwire); "The CACD President's…

  10. Decoupling the scholarly journal

    PubMed Central

    Priem, Jason; Hemminger, Bradley M.

    2011-01-01

    Although many observers have advocated the reform of the scholarly publishing system, improvements to functions like peer review have been adopted sluggishly. We argue that this is due to the tight coupling of the journal system: the system's essential functions of archiving, registration, dissemination, and certification are bundled together and siloed into tens of thousands of individual journals. This tight coupling makes it difficult to change any one aspect of the system, choking out innovation. We suggest that the solution is the “decoupled journal (DcJ).” In this system, the functions are unbundled and performed as services, able to compete for patronage and evolve in response to the market. For instance, a scholar might deposit an article in her institutional repository, have it copyedited and typeset by one company, indexed for search by several others, self-marketed over her own social networks, and peer reviewed by one or more stamping agencies that connect her paper to external reviewers. The DcJ brings publishing out of its current seventeenth-century paradigm, and creates a Web-like environment of loosely joined pieces—a marketplace of tools that, like the Web, evolves quickly in response to new technologies and users' needs. Importantly, this system is able to evolve from the current one, requiring only the continued development of bolt-on services external to the journal, particularly for peer review. PMID:22493574

  11. Existentialism in New Journalism.

    ERIC Educational Resources Information Center

    Dalmia, Shikha

    In 1977, John C. Merrill, a mass communication scholar, found that many scholars believed that the sixties movement of new journalism is in some way related to existentialism. To find this out, a study identified six main themes of the philosophy of existentialism (as espoused by Jean-Paul Sartre) and looked for the presence of these themes in the…

  12. From Conference to Journal

    ERIC Educational Resources Information Center

    McCartney, Robert; Tenenberg, Josh

    2008-01-01

    Revising and extending conference articles for journal publication benefits both authors and readers. The new articles are more complete, and benefit from peer review, feedback from conference presentation, and greater editorial consistency. For those articles that are appropriate, we encourage authors to do this, and present two examples of such…

  13. What are Journals for?

    PubMed Central

    2015-01-01

    ‘The secret is comprised in three words – work, finish, publish.’ Michael Faraday There are many reasons doctors want to publish their work. For most at an early stage in their career, this may be to add a line to their curriculum vitae and advance their careers but for academics, publishing is an expectation. Many will believe they have something important to say, and wish to provoke debate and discussion; others wish to share knowledge and experiences, which in medicine can lead to a satisfying change in clinical practice. All serve to register one’s idea and educate others. However, for some, the reason is as basic as money. As we celebrate the 350th anniversary of the first academic publication, perhaps we have come full circle when it comes to why people publish? Publishing is a flourishing business. There were approximately 28,100 active scholarly peer-reviewed journals in mid-2012, collectively publishing about 1.8–1.9 million articles per year. The number of articles published each year and the number of journals have both grown steadily for more than two centuries, by about 3% and 3.5% per year respectively.1 Journals have a responsibility to refine and define information and act as a scientific filter. Many of us will receive daily invitations in our email inbox from eclectic and new journals that are likely to take anything – is the filter now too porous? But this industry is like any other commercial activity and the supply still far outstrips the demand. Perhaps the internet revolution has merely fuelled our hunger to publish more? The launch of this exciting and innovative series about publishing coincides with the 350th celebration of the publication of the first academic journal. In the age of social media, the first question is ‘What are journals for?’, which Simon Rallison sets out to answer. Simon is Director of Publications at the Physiological Society, and was previously a journal publisher with Earthscan, Springer and Blackwell

  14. What are Journals for?

    PubMed

    Rallison, S P

    2015-03-01

    'The secret is comprised in three words - work, finish, publish.' Michael Faraday There are many reasons doctors want to publish their work. For most at an early stage in their career, this may be to add a line to their curriculum vitae and advance their careers but for academics, publishing is an expectation. Many will believe they have something important to say, and wish to provoke debate and discussion; others wish to share knowledge and experiences, which in medicine can lead to a satisfying change in clinical practice. All serve to register one's idea and educate others. However, for some, the reason is as basic as money. As we celebrate the 350th anniversary of the first academic publication, perhaps we have come full circle when it comes to why people publish? Publishing is a flourishing business. There were approximately 28,100 active scholarly peer-reviewed journals in mid-2012, collectively publishing about 1.8-1.9 million articles per year. The number of articles published each year and the number of journals have both grown steadily for more than two centuries, by about 3% and 3.5% per year respectively. (1) Journals have a responsibility to refine and define information and act as a scientific filter. Many of us will receive daily invitations in our email inbox from eclectic and new journals that are likely to take anything - is the filter now too porous? But this industry is like any other commercial activity and the supply still far outstrips the demand. Perhaps the internet revolution has merely fuelled our hunger to publish more? The launch of this exciting and innovative series about publishing coincides with the 350th celebration of the publication of the first academic journal. In the age of social media, the first question is 'What are journals for?', which Simon Rallison sets out to answer. Simon is Director of Publications at the Physiological Society, and was previously a journal publisher with Earthscan, Springer and Blackwell. Writing is

  15. Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.

    PubMed

    Starlard-Davenport, Athena; Tryndyak, Volodymyr P; James, Smitha R; Karpf, Adam R; Latendresse, John R; Beland, Frederick A; Pogribny, Igor P

    2010-03-01

    Breast cancer, the most common malignancy in women, emerges through a multistep process, encompassing the progressive sequential evolution of morphologically distinct stages from a normal cell to hyperplasia (with and without atypia), carcinoma in situ, invasive carcinoma and metastasis. The success of treatment of breast cancer could be greatly improved by the detection at early stages of cancer. In the present study, we investigated the underlying molecular mechanisms involved in breast carcinogenesis in Augustus and Copenhagen-Irish female rats, a cross between the ACI strains, induced by continuous exposure to 17beta-estradiol. The results of our study demonstrate that early stages of estrogen-induced breast carcinogenesis are characterized by altered global DNA methylation, aberrant expression of proteins responsible for the proper maintenance of DNA methylation pattern and epigenetic silencing of the critical Rassf1a (Ras-association domain family 1, isoform A) tumor suppressor gene. Interestingly, transcriptional repression of the Rassf1a gene in mammary glands during early stages of breast carcinogenesis was associated with an increase in trimethylation of histones H3 lysine 9 and H3 lysine 27 and de novo CpG island methylation and at the Rassf1a promoter and first exon. In conclusion, we demonstrate that epigenetic alterations precede formation of preneoplastic lesions indicating the significance of epigenetic events in induction of oncogenic pathways in early stages of carcinogenesis.

  16. Effect of crude extracts of selected actinomycetes on biofilm formation of A. schindleri, M. aci, and B. cereus.

    PubMed

    Saleem, Hafiz Ghulam Murtaza; Aftab, Usman; Sajid, Imran; Abbas, Zaigham; Sabri, Anjum Nasim

    2015-05-01

    Actinomycetes are well known group of gram positive bacteria for their potential to produce antibiotics. This study sought to assess the ability of the selected actinomycetes to control biofilm forming bacteria isolated from different dental plaque samples. On the basis of morphological differences three out of ten different dental plaque bacterial isolates were selected for further study. These isolates were biochemically and genetically characterized and were identified as Acinetobacter schinndleri, Moraxella aci, and Bacillus cereus. Antibiotic resistant profile was measured through disc diffusion method and found that all three isolates were moderately sensitive to ofloxacin and erythromycin and resistant to trimethoprim. Antibacterial activity of ten different Streptomyces strains was assessed through an agar plug and well diffusion method against three dental biofilm forming bacteria. Two Streptomyces strains named as S. erythrogriseus and S. labedae showed good antibacterial activity against Moraxella and Acinetobacter strains. Ability of the four active antibiotic producing strains to inhibit biofilm formation was assessed using microtiter biofilm detection assay. It was found that biofilm forming ability of Acinetobacter and Moraxella was inhibited by S. labedae an antibiotic producing strain, while S. macrosporeus can only inhibit biofilm formation by B. cereus.

  17. Growth Characteristics and Imaging Properties of the Morris Hepatoma 3924A in ACI Rats: A Suitable Model for Transarterial Chemoembolization

    SciTech Connect

    Truebenbach, Jochen; Graepler, Florian; Pereira, Philippe L.; Ruck, Peter; Lauer, Ulrich; Gregor, Michael; Claussen, Claus-D.; Huppert, Peter E.

    2000-03-15

    Purpose: For experimental studies investigating modalities and efficacy of transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) an animal model resembling the human situation as closely as possible would be appropriate. Specifically, reproducible tumor growth characteristics with the capability for appropriate in vivo imaging to monitor treatment efficacy are required.Methods: Morris hepatoma 3924A was implanted into the liver of 30 ACI rats. Tumor growth was followed by angiography (n = 10), ultrasound (US, n = 30), native computed tomography (CT, n = 16), and native magnetic resonance imaging (MRI, n = 30) between day 8 and day 36 after implantation. The radiological morphological characteristics were compared with the macroscopic and microscopic histological findings of the explanted tumors.Results: In all 30 animals a solitary liver tumor was found and macroscopically no signs of metastases, ascites, or peritoneal tumor were visible. On histopathological examination tumor sizes ranged between 27 {+-} 3 mm{sup 3} (day 8) and 3468 {+-} 79 mm{sup 3} (day 36). The first signs of tumor necrosis occurred at day 16. US allowed tumor visualization from day 8, MRI from day 8, angiography from day 10, and CT from day 14.Conclusions: The tumor model has the potential to be used for the visualization of tumor growth by MRI and US. The potential for monitoring therapeutic effects of TACE needs to be investigated.

  18. A/C(i) curve analysis across a range of woody plant species: influence of regression analysis parameters and mesophyll conductance.

    PubMed

    Manter, Daniel K; Kerrigan, Julia

    2004-12-01

    The analysis and interpretation of A/C(i) curves (net CO(2) assimilation rate, A, versus calculated substomatal CO(2) concentration, C(i)) is dependent upon a number of underlying assumptions. The influence of the C(i) value at which the A/C(i) curve switches between the Rubisco- and electron transport-limited portions of the curve was examined on A/C(i) curve parameter estimates, as well as the effect of mesophyll CO(2) conductance (g(m)) values on estimates of the maximum rate of Rubisco-mediated carboxylation (V(cmax)). Based on an analysis using 19 woody species from the Pacific Northwest, significant variation occurred in the C(i) value where the Rubisco- and electron transport-limited portions of the curve intersect (C(i_t)), ranging from 20 Pa to 152 Pa and averaging c. 71 Pa and 37 Pa for conifer and broadleaf species, respectively. Significant effects on estimated A/C(i) parameters (e.g. V(cmax)) may arise when preliminary estimates of C(i_t), necessary for the multiple regression analyses, are set either too high or too low. However, when the appropriate threshold is used, a significant relationship between A/C(i) and chlorophyll fluorescence estimates of carboxylation is achieved. The use of the V(cmax) parameter to describe accurately the Rubisco activity from the A/C(i) curve analysis is also dependent upon the assumption that C(i) is approximately equal to chloroplast CO(2) concentrations (C(c)). If leaf mesophyll conductance is low, C(c) will be much lower than C(i) and will result in an underestimation of V(cmax) from A/C(i) curves. A large range of mesophyll conductance (g(m)) values was observed across the 19 species (0.005+/-0.002 to 0.189+/-0.011 mol m(-2) s(-1) for Tsuga heterophylla and Quercus garryana, respectively) and, on average, g(m) was 1.9 times lower for the conifer species (0.058+/-0.017 mol m(-2) s(-1) for conifers versus 0.112+/-0.020 mol m(-2) s(-1) for broadleaves). When this mesophyll limitation was accounted for in V

  19. Positioning Open Access Journals in a LIS Journal Ranking

    ERIC Educational Resources Information Center

    Xia, Jingfeng

    2012-01-01

    This research uses the h-index to rank the quality of library and information science journals between 2004 and 2008. Selected open access (OA) journals are included in the ranking to assess current OA development in support of scholarly communication. It is found that OA journals have gained momentum supporting high-quality research and…

  20. Three journal similarity metrics and their application to biomedical journals.

    PubMed

    D'Souza, Jennifer L; Smalheiser, Neil R

    2014-01-01

    In the present paper, we have created several novel journal similarity metrics. The MeSH odds ratio measures the topical similarity of any pair of journals, based on the major MeSH headings assigned to articles in MEDLINE. The second metric employed the 2009 Author-ity author name disambiguation dataset as a gold standard for estimating the author odds ratio. This gives a straightforward, intuitive answer to the question: Given two articles in PubMed that share the same author name (lastname, first initial), how does knowing only the identity of the journals (in which the articles were published) predict the relative likelihood that they are written by the same person vs. different persons? The article pair odds ratio detects the tendency of authors to publish repeatedly in the same journal, as well as in specific pairs of journals. The metrics can be applied not only to estimate the similarity of a pair of journals, but to provide novel profiles of individual journals as well. For example, for each journal, one can define the MeSH cloud as the number of other journals that are topically more similar to it than expected by chance, and the author cloud as the number of other journals that share more authors than expected by chance. These metrics for journal pairs and individual journals have been provided in the form of public datasets that can be readily studied and utilized by others.

  1. The Writer's Journal: 40 Contemporary Writers and Their Journals.

    ERIC Educational Resources Information Center

    Bender, Sheila, Ed.

    This anthology presents excerpts from the journals of 40 of today's most noted writers, along with their comments on the role of journal-keeping in creating their art. Besides being generally instructional to other writers and a lesson in how to create a personal journal, the anthology is a look at writers in the midst of creating. It includes…

  2. Making sense of journal publishing

    NASA Astrophysics Data System (ADS)

    Campbell, Robert

    1982-10-01

    With cut-backs in library budgets it is hard to understand why new journals continue to appear. Here Robert Campbell discusses the economics of journal publishing and the prognosis for this part of the scientific literature.

  3. Publishing corruption discussion: predatory journalism.

    PubMed

    Jones, James W; McCullough, Laurence B

    2014-02-01

    Dr Spock is a brilliant young vascular surgeon who is up for tenure next year. He has been warned by the chair of surgery that he needs to increase his list of publications to assure passage. He has recently had a paper reviewed by one of the top journals in his specialty, Journal X-special, with several suggestions for revision. He received an e-mail request for manuscript submission from a newly minted, open access, Journal of Vascular Disease Therapy, which promises a quick and likely favorable response for a fee. What should be done? A. Send the paper to another peer reviewed journal with the suggested revisions. B. Resubmit the paper to Journal X-special. C. Submit to the online journal as is to save time. D. Submit to the online journal and another regular journal. E. Look for another job.

  4. Our World: Journaling in Space

    NASA Video Gallery

    Learn how famous explorers, scientists and even NASA use journals and science notebooks to record observations about Our World. See why journaling is important on the International Space Station to...

  5. Comparison of cortical epileptic afterdischarges in immature genetic absence epilepsy WAG/Rij rats with those in two other strains (ACI and Wistar).

    PubMed

    Mares, Pavel; Tolmacheva, Elena

    2007-01-01

    The aim of this study was to examine the development of cortical epileptic afterdischarges (ADs) in genetic absence epilepsy WAG/Rij rats, and to compare them with two strains with minimal incidence of spike-and-wave (SW) episodes (ACI and Wistar). Epileptic ADs were elicited by stimulation of sensorimotor cortex in 12-, 18-, and 25-day-old rats of the three strains. The threshold current intensities were established for movements accompanying stimulation, for ADs of the SW type and accompanying clonic seizures and for transition into limbic type of ADs (characterized by behavioral automatisms). Individual groups were formed by 7-12 rats. There were no differences among the three strains in the thresholds for elicitation of stimulation-bound movements. In contrast, WAG/Rij and ACI rats exhibited easier elicitation of SW ADs than Wistar rats at the age of 18 and 25 days. There was no difference among the three strains in transition into the limbic type of ADs in 18- and 25-day-old rats. Lower thresholds for SW ADs in 18- and 25-day-old WAG/Rij and ACI rats in comparison with Wistar rats are in agreement with our data from adult animals as well as with development of pharmacologically induced models of absence seizures. The failure to find a specific difference between WAG/Rij rats and the other two strains might indicate a difference in generation of SW episodes and SW cortical AD.

  6. Cascade impactor practice for a high dose dry powder inhaler at 90 L/min: NGI versus modified 6-stage and 8-stage ACI.

    PubMed

    Kamiya, Akihiko; Sakagami, Masahiro; Byron, Peter R

    2009-03-01

    The compendial methods of particle size distribution (PSD) profile determination for dry powder inhalers (DPIs) were compared between the Next Generation Pharmaceutical Impactor (NGI) and the Andersen Cascade Impactor (ACI). Relenza Rotadisk (zanamivir) and Diskhaler was used as a model DPI and sampled into each impactor via its preseparator (PS), at 90 L/min under various protocols. In the NGI, silicone coating was shown to be indispensable to prevent or minimize particle bounce and reentrainment, and to reduce wall losses to the levels acceptable to the compendia (5%). In contrast, the ACI exceeded this 5% limit, regardless of coating, implying different wall loss mechanisms from the NGI. Particle bounce occurred in both impactors, inaccurately undersizing the PSD profiles for Relenza, unless the collection surfaces were coated or an increased number of doses were employed. Hence, the PSD profile for Relenza following single dose collection in the stage-coated NGI was the most accurate. In contrast, the use of the ACI and its PS for Relenza at 90 L/min suffered from several problems, even though the poorly designed PS still resulted in consistent impactor dose and PSD profiles, compared to those obtained from the NGI and its PS.

  7. Dietary clofibrate stimulates the formation and size of estradiol-induced breast tumors in female August-Copenhagen Irish (ACI) rats.

    PubMed

    Mesia-Vela, Sonia; Sanchez, Rosa I; Roberts, Kathleen G; Reuhl, Kenneth R; Conney, Allan H; Kauffman, Frederick C

    2008-04-03

    Administration of 0.4% clofibrate in the diet stimulated estradiol (E(2))-induced mammary carcinogenesis in the August-Copenhagen Irish (ACI) rat without having an effect on serum levels of E(2). This treatment stimulated by several-fold the NAD(P)H-dependent oxidative metabolism of E(2) and oleyl-CoA-dependent esterification of E(2) to 17beta-oleyl-estradiol by liver microsomes. Glucuronidation of E(2) by microsomal glucuronosyltransferase was increased moderately. In contrast, the activity of NAD(P)H quinone reductase 1 (NQO1), a representative monofunctional phase 2 enzyme, was significantly decreased in liver cytosol of rats fed clofibrate. Decreases in hepatic NQO1 in livers of animals fed clofibrate were noted before the appearance of mammary tumors. E(2) was delivered in cholesterol pellets implanted in 7-8-week-old female ACI rats. The animals received AIN-76A diet containing 0.4% clofibrate for 6, 12 or 28 weeks. Control animals received AIN-76A diet. Dietary clofibrate increased the number and size of palpable mammary tumors but did not alter the histopathology of the E(2)-induced mammary adenocarcinomas. Collectively, these results suggest that the stimulatory effect of clofibrate on hepatic esterification of E(2) with fatty acids coupled with the inhibition of protective phase 2 enzymes, may in part, enhance E(2)-dependent mammary carcinogenesis in the ACI rat model.

  8. Practical Ideas for Teaching Journalism.

    ERIC Educational Resources Information Center

    Bustrum, Dwight, Ed.; Hallenbeck, Carol, Ed.; Rittger, Alison, Ed.

    A "how-to" book for advisers looking for creative and contemporary ways to teach journalism, this book can be a single source for a journalism class or a supplement to any high school journalism text. The book concentrates on teaching methods as well as subject matter--it tells teachers what to do and how to do it, what to say and what…

  9. Journalism in a Free Society.

    ERIC Educational Resources Information Center

    Edwards, Verne E., Jr.

    Broadcast and print journalism are interrelated in this book's coverage of the functions and status of the "fourth estate". A first part discusses journalism's magnitude and significance, with separate chapters offering a profile of the press, a discussion of the people's need to know, and a brief history of American journalism. The second part…

  10. Scholastic Journalism Education: Benchmark 1982.

    ERIC Educational Resources Information Center

    Shenton, Stephen G-M.; Smith, Anne

    Noting that no institution listed in "Accredited Journalism and Mass Communications Education, 1981-82" offers a scholastic journalism or secondary education sequence accredited by the American Council on Education in Journalism and Mass Communications, a study was conducted to examine the courses in the sequences that were offered at the…

  11. Evaluation of OAS Education Journals.

    ERIC Educational Resources Information Center

    Leavitt, Howard B.; And Others

    An in-depth evaluation of four Organization of American States educational journals is presented. The journals, published for distribution among Latin American countries, were "Tecnologia Educativa", "Curriculum", "Educacion de Adultors", and "La Educacion". Assessment was made of the journals' mandates, implementation procedures, and managerial…

  12. Journalism and Writing: A Roundtable.

    ERIC Educational Resources Information Center

    ABCA Bulletin, 1983

    1983-01-01

    Authors discuss (1) journalism and business writing as ways of learning to write, (2) differences between journalism and business writing, (3) a journalistic approach to solving business communication problems, and (4) business communication and journalism sharing a common goal of effective communication. (HTH)

  13. Citing Legal Material in APA Journals.

    ERIC Educational Resources Information Center

    Osborne, Allan G., Jr.

    1992-01-01

    Guidelines are offered to authors on the correct citation format for legal references, including statutes and regulations, court decisions, and law review articles. Standards are based on those published by the Harvard Law Review Association and the American Psychological Association. (DB)

  14. Hydrogeology Journal in 2002

    USGS Publications Warehouse

    Olcott, Perry; Schneider, Robert; Voss, Clifford

    2003-01-01

    Hydrogeology Journal appeared in six issues containing a total of 674 pages and 47 major articles, including 22 Papers and 24 Reports, as well as Technical Notes and Book Reviews. The final issue of 2002 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines. Authors in 2002 were from about 30 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on 22 countries: Afghanistan, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, India, Israel, Japan, Jordan, Mexico, New Zealand, Nigeria, Portugal, Qatar, Switzerland, Syria, Turkey, UK, and the USA. The Guest Editors of the 2002 HJ theme issue on "Groundwater Recharge", Bridget R. Scanlon and Peter G. Cook, assembled a highly relevant and sought-after collection of papers from eminent authors on wide-ranging aspects of the subject.

  15. Bibliography of Journal Holdings

    DTIC Science & Technology

    1988-06-01

    Abstract iournal of metallurgy (1958)-(1963) Part B. Technology of metals Academie Polonaise des Sciences. V.18 (1970)- Bulletin (Maths, astronom et ...V.18 (1966) Aeronautique et lastronautique (1969)-(1986) Aeroplane. Incorporated in Flight V.71 (1946)- imperfect international from December 1968...ATandT Bell laboratories tachi , al journal Bibliography on industrial diamond V.6 (1949)- imperfect applications. Title changed to V.14 (1957

  16. Induction of A.T to G.C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats.

    PubMed

    Mailander, Paula C; Meza, Jane L; Higginbotham, Sheila; Chakravarti, Dhrubajyoti

    2006-11-01

    Evidence suggests that the genotoxic mechanism of estrogens (estrone/estradiol) in breast cancer involves their oxidation to 3,4-quinones and reaction with DNA to form depurinating N3Ade and N7Gua adducts. We examined whether estrogen genotoxicity is mutagenic in the mammary gland of the female ACI rat, a model for estrogen-dependent breast cancer. Mutagenesis was studied by PCR amplification of the H-ras1 gene (exons 1-2), cloning in pUC18, transforming Escherichia coli, and sequencing the inserts in plasmids from individual colonies. Mammary glands of both estrogen-responsive (ACI and DA) and resistant (Sprague-Dawley) rats contained pre-existing mutations at frequencies of (39.8-58.8)x10(-5), the majority (62.5-100%) of which were A.T to G.C transitions. Estradiol-3,4-quinone (200 nmol) treatment of ACI rats caused rapid (6h to 1 day) mutagenesis (frequency (83.3-156.1)x10(-5); A.T to G.C 70-73.3%). The estrogen-induced A.T to G.C mutations were detected as G.T heteroduplexes, as would be expected if N3Ade depurinations caused Gua misincorporations by erroneous repair. These heteroduplexes were identified by the T.G-DNA glycosylase (TDG) assay. TDG converts G.T heteroduplexes to G.abasic sites, rendering DNA templates refractory to PCR amplification. Consequently, A.T to G.C mutations present as G.T heteroduplexes in the DNA are eliminated from the spectra. TDG treatment of mammary DNA from estradiol-3,4-quinone-treated ACI rats brought A.T to G.C mutations down to pre-existing frequencies. Our results demonstrate that treatment with estradiol-3,4-quinone, an important metabolite of estrogens, produced A.T to G.C mutations in the DNA of the mammary gland of ACI rats.

  17. Essay: early American genetics journals.

    PubMed

    Crow, James F

    2005-09-01

    Before the Second World War, there were only two North-American journals exclusively devoted to genetics - the Journal of Heredity and Genetics. In the late 1940s, Genetics spawned two progeny - the American Journal of Human Genetics and Evolution. This article recounts the early days of these journals, their influential and often colourful founding editors, and their contents. It emphasizes the contrast between those years, when a reader had a realistic chance of keeping up with the whole field, and the current plethora of journals that makes it impossible to keep up with even the tables of contents.

  18. Journal bias or author bias?

    PubMed

    Harris, Ian

    2016-01-01

    I read with interest the comment by Mark Wilson in the Indian Journal of Medical Ethics regarding bias and conflicts of interest in medical journals. Wilson targets one journal (the New England Journal of Medicine: NEJM) and one particular "scandal" to make his point that journals' decisions on publication are biased by commercial conflicts of interest (CoIs). It is interesting that he chooses the NEJM which, by his own admission, had one of the strictest CoI policies and had published widely on this topic. The feeling is that if the NEJM can be guilty, they can all be guilty.

  19. Elsevier challenged over journal operations

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2009-01-01

    Researchers are questioning the method used to monitor the quality of a scientific journal belonging to the Dutch publishing giant Elsevier after its editor-in-chief was found to be publishing almost all his papers in the journal. Mohamed El Naschie, editor-in-chief of Chaos, Solitons and Fractals (CSF), published 58 papers last year, of which 53 are in the journal itself. Elsevier will announce his retirement from CSF, which had been planned since mid-2007, in the first issue of the journal this year. The company also plans to revamp the journal's submission process.

  20. Journal Self-Citedness in "Journal Citation Reports" Library and Information Science and Genetics Journal Rankings.

    ERIC Educational Resources Information Center

    Nisonger, Thomas E.

    1998-01-01

    Investigates the effect of journal self-citedness on "Journal Citation Reports" (JCR) rankings of library and information science and genetics journals using data from 1994 on CD-ROM. Results for library and information science indicate that the effect of self-citedness on both JCR impact factor and total citation rankings was minimal.…

  1. CHANDRA ACIS SURVEY OF X-RAY POINT SOURCES IN 383 NEARBY GALAXIES. I. THE SOURCE CATALOG

    SciTech Connect

    Liu Jifeng

    2011-01-15

    The Chandra data archive is a treasure for various studies, and in this paper we exploit this valuable resource to study the X-ray point source populations in nearby galaxies. By 2007 December 14, 383 galaxies within 40 Mpc with isophotal major axis above 1 arcmin had been observed by 626 public ACIS observations, most of which were for the first time analyzed by this survey to study the X-ray point sources. Uniform data analysis procedures are applied to the 626 ACIS observations and lead to the detection of 28,099 point sources, which belong to 17,599 independent sources. These include 8700 sources observed twice or more and 1000 sources observed 10 times or more, providing us a wealth of data to study the long-term variability of these X-ray sources. Cross-correlation of these sources with galaxy isophotes led to 8519 sources within the D{sub 25} isophotes of 351 galaxies, 3305 sources between the D{sub 25} and 2D{sub 25} isophotes of 309 galaxies, and additionally 5735 sources outside 2D{sub 25} isophotes of galaxies. This survey has produced a uniform catalog, by far the largest, of 11,824 X-ray point sources within 2D{sub 25} isophotes of 380 galaxies. Contamination analysis using the log N-log S relation shows that 74% of sources within 2D{sub 25} isophotes above 10{sup 39} erg s{sup -1}, 71% of sources above 10{sup 38} erg s{sup -1}, 63% of sources above 10{sup 37} erg s{sup -1}, and 56% of all sources are truly associated with galaxies. Meticulous efforts have identified 234 X-ray sources with galactic nuclei of nearby galaxies. This archival survey leads to 300 ultraluminous X-ray sources (ULXs) with L{sub X} (0.3-8 keV) {>=} 2 x 10{sup 39} erg s{sup -1}within D{sub 25} isophotes, 179 ULXs between D{sub 25} and 2D{sub 25} isophotes, and a total of 479 ULXs within 188 host galaxies, with about 324 ULXs truly associated with host galaxies based on the contamination analysis. About 4% of the sources exhibited at least one supersoft phase, and 70 sources are

  2. X-ray emission from the Wolf-Rayet bubble NGC 6888. I. Chandra ACIS-S observations

    SciTech Connect

    Toalá, J. A.; Guerrero, M. A.

    2014-02-01

    We analyze Chandra observations of the Wolf-Rayet (W-R) bubble NGC 6888. This W-R bubble presents similar spectral and morphological X-ray characteristics to those of S 308, the only other W-R bubble also showing X-ray emission. The observed spectrum is soft, peaking at the N VII line emission at 0.5 keV, with additional line emission at 0.7-0.9 keV and a weak tail of harder emission up to ∼1.5 keV. This spectrum can be described by a two-temperature optically thin plasma emission model (T {sub 1} ∼ 1.4 × 10{sup 6} K, T {sub 2} ∼ 7.4 × 10{sup 6} K). We confirm the results of previous X-ray observations that no noticeable temperature variations are detected in the nebula. The X-ray-emitting plasma is distributed in three apparent morphological components: two caps along the tips of the major axis and an extra contribution toward the northwest blowout not reported in previous analyses of the X-ray emission toward this W-R nebula. Using the plasma model fits of the Chandra ACIS spectra for the physical properties of the hot gas and the ROSAT PSPC image to account for the incomplete coverage of Chandra observations, we estimate a luminosity of L {sub X} = (7.7 ± 0.1) ×10{sup 33} erg s{sup –1} for NGC 6888 at a distance of 1.26 kpc. The average rms electron density of the X-ray-emitting gas is ≳ 0.4 cm{sup –3} for a total mass ≳ 1.2 M {sub ☉}.

  3. [Contribution of microCT structural imaging to preclinical evaluation of hepatocellular carcinoma chemotherapeutics on orthotopic graft in ACI rats].

    PubMed

    Akladios, Cherif Youssef; Bour, Gaëtan; Balboni, Ginette; Mutter, Didier; Marescaux, Jacques; Aprahamian, Marc

    2011-02-01

    Animal experimentation is a prerequisite for preclinical evaluation of treatments such as chemotherapy. It's strictly regulated with the purpose of reducing the number of experimental animal as well as their pain. Small animal imaging should provide a painless longitudinal follow up of tumor progression on a single animal. The aim of the study is to validate small animal imaging by microscanner (μscan) in longitudinal follow up of a hepatocellular carcinoma (HCC) and to demonstrate its interest for in vivo evaluation of tumor response to different therapeutics. An HCC model achieved by orthotopic graft of the MH3924A cell line in ACI rats was followed using a Imtek/Siemens microscanner (μscan) with contrast agents (Fenestra(®) LC/VC). The procedures giving the optimal enhancement of the liver as well as a reliable determination of tumor volumes by μscan were validated. Three protocols for therapeutic assessment through μscan longitudinal follow up were performed. Each consisted in three groups testing a chemotherapy (gemcitabine, gemcitabine-oxaliplatine or sorafenib) versus two control groups (placebo and doxorubicine). Comparison was done on tumor volumes, median and actual survivals. There was a significant correlation between tumor volumes measured by μscan and autopsy. Treatment by sorafenib, at the contrary of gemcitabine alone or with oxaliplatine, resulted in a significant reduction in tumor volumes and prolongation of actuarial survival. These results are consistent with available clinical data for these diverse therapeutics. In conclusion, small animal imaging with μscan is a non-invasive, reliable, and reproducible method for preclinical evaluation of antitumor agents.

  4. CHANDRA/ACIS-I STUDY OF THE X-RAY PROPERTIES OF THE NGC 6611 AND M16 STELLAR POPULATIONS

    SciTech Connect

    Guarcello, M. G.; Drake, J. J.; Caramazza, M.; Micela, G.; Sciortino, S.; Prisinzano, L.

    2012-07-10

    Mechanisms regulating the origin of X-rays in young stellar objects and the correlation with their evolutionary stage are under debate. Studies of the X-ray properties in young clusters allow us to understand these mechanisms. One ideal target for this analysis is the Eagle Nebula (M16), with its central cluster NGC 6611. At 1750 pc from the Sun, it harbors 93 OB stars, together with a population of low-mass stars from embedded protostars to disk-less Class III objects, with age {<=}3 Myr. We study an archival 78 ks Chandra/ACIS-I observation of NGC 6611 and two new 80 ks observations of the outer region of M16, one centered on the Column V and the other on a region of the molecular cloud with ongoing star formation. We detect 1755 point sources with 1183 candidate cluster members (219 disk-bearing and 964 disk-less). We study the global X-ray properties of M16 and compare them with those of the Orion Nebula Cluster. We also compare the level of X-ray emission of Class II and Class III stars and analyze the X-ray spectral properties of OB stars. Our study supports the lower level of X-ray activity for the disk-bearing stars with respect to the disk-less members. The X-ray luminosity function (XLF) of M16 is similar to that of Orion, supporting the universality of the XLF in young clusters. Eighty-five percent of the O stars of NGC 6611 have been detected in X-rays. With only one possible exception, they show soft spectra with no hard components, indicating that mechanisms for the production of hard X-ray emission in O stars are not operating in NGC 6611.

  5. Calculating impact factor: how bibliographical classification of journal items affects the impact factor of large and small journals.

    PubMed

    Golubic, Rajna; Rudes, Mihael; Kovacic, Natasa; Marusic, Matko; Marusic, Ana

    2008-03-01

    As bibliographical classification of published journal items affects the denominator in this equation, we investigated how the numerator and denominator of the impact factor (IF) equation were generated for representative journals in two categories of the Journal Citation Reports (JCR). We performed a full text search of the 1st-ranked journal in 2004 JCR category "Medicine, General and Internal" (New England Journal of Medicine, NEJM, IF = 38.570) and 61st-ranked journal (Croatian Medical Journal, CMJ, IF = 0.690), 1st-ranked journal in category "Multidisciplinary Sciences" (Nature, IF = 32.182) and journal with a relative rank of CMJ (Anais da Academia Brasileira de Ciencias, AABC, IF = 0.435). Large journals published more items categorized by Web of Science (WoS) as non-research items (editorial material, letters, news, book reviews, bibliographical items, or corrections): 63% out of total 5,193 items in Nature and 81% out of 3,540 items in NEJM, compared with 31% out of 283 items in CMJ and only 2 (2%) out of 126 items in AABC. Some items classified by WoS as non-original contained original research data (9.5% in Nature, 7.2% in NEJM, 13.7% in CMJ and none in AABC). These items received a significant number of citations: 6.9% of total citations in Nature, 14.7% in NEJM and 18.5% in CMJ. IF decreased for all journals when only items presenting original research and citations to them were used for IF calculation. Regardless of the journal's size or discipline, publication of non-original research and its classification by the bibliographical database have an effect on both numerator and denominator of the IF equation.

  6. The Journal of Anatomy: origin and evolution.

    PubMed

    Morriss-Kay, Gillian

    2016-07-01

    The Journal of Anatomy was launched 150 years ago as the Journal of Anatomy and Physiology, in an age when anatomy and physiology were not regarded as separate disciplines. European science in general was advancing rapidly at the time (it was 7 years after publication of Darwin's Origin of Species), and the recent demise of the Natural History Review meant that there was no English language publication covering these subjects. The founding editors were George Murray Humphry of Cambridge and William Turner of Edinburgh, together with Alfred Newton of Cambridge and Edward Perceval Wright of Dublin (the last two served only for a year). The pivotal event leading to the Journal's foundation was the 1866 meeting of the British Association, at which Humphry delivered the 'Address in Physiology' (printed in the first issue). Turner, who was also present at the 1866 British Association meeting, remained as a member of the editorial team for 50 years and was a major contributor of Journal articles. The title was changed to Journal of Anatomy in October 1916, when it was taken under the wing, in terms of both management and ownership, by the Anatomical Society. This article reviews the early years of the Journal's publication in more detail than later years because of the historical interest of this less familiar material. The subject matter, which has remained surprisingly consistent over the years, is illustrated by examples from some notable contributions. The evolution of illustration techniques is surveyed from 1866 to the present day; the final section provides brief summaries of all of the chief editors.

  7. ISI's Journal Citation Reports on the Web.

    PubMed

    Fitzpatrick, Roberta Bronson

    2003-01-01

    This column features an overview of the Institute for Scientific Information's (ISI) Journal Citation Reports (JCR) database. Basic searching techniques are presented, as well as simple ways to manipulate data contained in the file. The Journal Citation Reports database can provide information on highest impact journals, most frequently used journals, "hottest" journals, and largest journals in a field or discipline.

  8. Algorithmic Procedure for Finding Semantically Related Journals.

    ERIC Educational Resources Information Center

    Pudovkin, Alexander I.; Garfield, Eugene

    2002-01-01

    Using citations, papers and references as parameters a relatedness factor (RF) is computed for a series of journals. Sorting these journals by the RF produces a list of journals most closely related to a specified starting journal. The method appears to select a set of journals that are semantically most similar to the target journal. The…

  9. Dialogue Journal Bibliography: Published Works about Dialogue Journal Research and Use.

    ERIC Educational Resources Information Center

    Peyton, Joy Kreeft; Staton, Jana

    This annotated bibliography refers to extensive material available for teachers, researchers, and administrators desiring to know more about dialogue journal use and research with many different student populations, from elementary through adult education, regarding teaching English-as-a-Second-Language. It is divided into four sections. Section…

  10. New NAS journal

    NASA Astrophysics Data System (ADS)

    In April 1984 the National Academy of Sciences (NAS) will begin publishing a new quarterly focusing on science policy. Written primarily for legislators, diplomats, corporate managers, security analysts, and other public policy analysts, the new journal will deal with such diverse topics as arms control, economic competition, social change, and health care.Original articles are expected to create a 120-page periodical that will discuss policy issues on a sophisticated but nonspecialist level, in a manner similar to that which Foreign Affairs uses to discuss U.S. foreign policy topics, according to NAS.

  11. Overall pattern of publication in Journal of Conservative Dentistry

    PubMed Central

    Dharmani, Umesh Kumar; Devi, T. Premlata; Sh. Priyadarshini; Jadhav, Ganesh; Dharmani, Charan Kamal Kaur; Singh, Bishnupati; Kumar, Vinay

    2016-01-01

    Background: The Journal of Conservative Dentistry (JCD) has been online since 2008. Materials and Methods: This paper reviews the publication in this journal over a 5-year period (2011–2015). It assesses the types of articles published, coverage of various types of subjects of endodontics, and conservative dentistry in the journal and explores the authorship patterns in the publication and citation of the journal over this period. Results and Conclusion: JCD has delivered broad-based, balanced coverage of endodontics and conservative dentistry between 2011 and 2015, with contributions from all over India, as well as abroad. Although a maximum number of articles were from India, the publications from other countries are also on an increase. Thus, the widespread coverage of this journal suggests that JCD has begun to represent the global face of the Indian Association of Conservative Dentistry and Endodontics. PMID:27656069

  12. Materialism.

    PubMed

    Melnyk, Andrew

    2012-05-01

    Materialism is nearly universally assumed by cognitive scientists. Intuitively, materialism says that a person's mental states are nothing over and above his or her material states, while dualism denies this. Philosophers have introduced concepts (e.g., realization and supervenience) to assist in formulating the theses of materialism and dualism with more precision, and distinguished among importantly different versions of each view (e.g., eliminative materialism, substance dualism, and emergentism). They have also clarified the logic of arguments that use empirical findings to support materialism. Finally, they have devised various objections to materialism, objections that therefore serve also as arguments for dualism. These objections typically center around two features of mental states that materialism has had trouble in accommodating. The first feature is intentionality, the property of representing, or being about, objects, properties, and states of affairs external to the mental states. The second feature is phenomenal consciousness, the property possessed by many mental states of there being something it is like for the subject of the mental state to be in that mental state. WIREs Cogn Sci 2012, 3:281-292. doi: 10.1002/wcs.1174 For further resources related to this article, please visit the WIREs website.

  13. Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen.

    PubMed

    Weroha, S John; Lingle, Wilma L; Hong, Yan; Li, Sara Antonia; Li, Jonathan J

    2010-02-01

    Overexpressed Aurora A, amplified centrosomes, and aneuploidy are salient features of estrogen-induced mammary preinvasive lesions and tumors in female August--Copenhagen Irish (ACI) rats. Intimately involved in these events are cyclins and their associated cyclin-dependent kinase (CDK) partners. Cyclin E1·CDK2 overexpression plays an important dual role in late G1/S phase of the cell cycle in cancer cells. It increases DNA replication providing growth advantage to cancer cells and facilitates aberrant centrosome duplication, generating chromosomal instability and aneuploidy leading to tumor development. Presented herein, a 24.0- and 45.0-fold elevation in cyclin E1 and CDK2 was found in 17β-estradiol (E(2))-induced ACI rat mammary tumors (MTs), respectively. Cyclin E·CDK2 positive staining was confined to the large round cells found within focal dysplasias, ductal carcinomas in situ, and invasive MTs. Co-immunoprecipitation and in vitro kinase activity of these tumors revealed that these cell cycle entities are functional. When mammary tissue derived from untreated normal, E(2)-induced hyperplasia and primary tumors were normalized to cyclin E1 levels, low molecular weight (LMW) cyclin E1 forms (33- and 45-kDa) were detected in all of these tissue groups. Moreover, increasing concentrations of protease inhibitor in tissue lysates resulted in a marked reduction of LMW forms, indicating that the presence of cyclin E1 LMW forms can be markedly reduced. Significant increases in cyclin E1 mRNA (2.1-fold) were detected in primary ACI rat E(2)-induced breast tumors, and quantitative real-time polymerase chain reaction revealed a 20% amplification of the cyclin E1 gene (CCNE1). Collectively, these results support the involvement of cyclin E1·CDK2 in centrosome overduplication during each stage of E(2)-induced mammary tumorigenesis.

  14. Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated andersen cascade impactors (ACIs): part 1.

    PubMed

    Mitchell, Jolyon P; Nagel, Mark W; Doyle, Cathy C; Ali, Rubina S; Avvakoumova, Valentina I; Christopher, J David; Quiroz, Jorge; Strickland, Helen; Tougas, Terrence; Lyapustina, Svetlana

    2010-06-01

    The purpose of this study was to compare relative precision of two different abbreviated impactor measurement (AIM) systems and a traditional multi-stage cascade impactor (CI). The experimental design was chosen to provide separate estimates of variability for each impactor type. Full-resolution CIs are useful for characterizing the aerosol aerodynamic particle size distribution of orally inhaled products during development but are too cumbersome, time-consuming, and resource-intensive for other applications, such as routine quality control (QC). This article presents a proof-of-concept experiment, where two AIM systems configured to provide metrics pertinent to QC (QC-system) and human respiratory tract (HRT-system) were evaluated using a hydrofluoroalkane-albuterol pressurized metered dose inhaler. The Andersen eight-stage CI (ACI) served as the benchmark apparatus. The statistical design allowed estimation of precision with each CI configuration. Apart from one source of systematic error affecting extra-fine particle fraction from the HRT-system, no other bias was detected with either abbreviated system. The observed bias was shown to be caused by particle bounce following the displacement of surfactant by the shear force of the airflow diverging above the collection plate of the second impaction stage. A procedure was subsequently developed that eliminated this source of error, as described in the second article of this series (submitted to AAPS PharmSciTech). Measurements obtained with both abbreviated impactors were very similar in precision to the ACI for all measures of in vitro performance evaluated. Such abbreviated impactors can therefore be substituted for the ACI in certain situations, such as inhaler QC or add-on device testing.

  15. Online directed journaling in dental hygiene clinical education.

    PubMed

    Gwozdek, Anne E; Klausner, Christine P; Kerschbaum, Wendy E

    2009-01-01

    Reflecting upon and sharing of clinical experiences in dental hygiene education is a strategy used to support the application of didactic material to patient care. The promotion of interactive, clinically focused discussions creates opportunities for students to foster critical thinking and socialization skills in dental hygiene practice. Twenty-eight dental hygiene students in their first semester of patient care utilized online directed journaling via blogging software, as a reflection and sharing strategy. Journal entries found critical thinking and socialization themes including connection of didactic material to clinical experience, student-patient interaction, student-student collaboration, and a vision of the professional role of the dental hygienist. A 7 item evaluation instrument provided data that the online journaling strategy was perceived as effective and valuable by the students. Online directed journaling is a strategy that has the potential to enhance critical thinking and socialization skills in dental hygiene clinical education.

  16. Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis

    PubMed Central

    Jiang, Yanming; Chen, Changxian; Li, Li

    2017-01-01

    Objective The objective of this systematic review was to conduct a more comprehensive literature search and meta-analysis of original studies to evaluate the efficacy and safety of the loop electrosurgical excision procedure (LEEP) versus cold-knife conization (CKC) in conservative surgical treatment of cervical adenocarcinoma in situ (ACIS) for women who have not completed childbearing. Methods Systematic searches were conducted in the PUBMED, EMBASE, Cochrane, and China National Knowledge Infrastructure (CNKI) databases to identify all potential studies involving patients with ACIS treated with LEEP versus CKC published until December 2015. Results Eighteen retrospective studies were included in this systematic review. All the 18 included studies reported the rate of positive margins, and the results of the individual studies varied. The positive margins were 44% (267/607) after LEEP and 29% (274/952) after CKC. The pooled meta-analysis exhibited significantly different outcome (RR, 1.55; 95% CI, 1.34–1.80, P<0.00001) without significant heterogeneity (P = 0.34). The residual rate following LEEP was 9.1% (17/186) and 11% (39/350) after CKC in re-cone or hysterectomy cases. Recurrent ACIS following LEEP was reported in 10 of 142 (7.0%) cases compared to 10 of 177 (5.6%) cases following CKC. There were no significant differences in the residual rate (RR, 1.02; 95% CI, 0.60–1.72, P = 0.95) or recurrence rate (RR, 1.13; 95% CI, 0.46–2.79; P = 0.79) between the two procedures. Conclusions The present systematic review demonstrates that both LEEP and CKC are safe and effective for the conservative treatment of ACIS. LEEP appears to be as equally effective as CKC regarding the residual and recurrence rates. Due to the findings showing that LEEP achieves comparable oncologic outcomes with fewer obstetric complications to that of CKC, LEEP may be the preferred option in patients whose fertility preservation is important. However, further prospective studies with a

  17. Le journal litteraire: une decouverte (The Literary Journal: A Discovery).

    ERIC Educational Resources Information Center

    Pelletier, Christine

    1999-01-01

    To encourage the students in her French class to read books in French, a teacher implemented a project involving literary journals. Students recorded their reflections on their reading, first of a novel chosen by the teacher, then of individually chosen novels. Appropriate evaluation of the journals posed a particular dilemma. (JLR)

  18. Style in medical journals.

    PubMed Central

    Adams Smith, D E

    1983-01-01

    A study of medical journals from 1962 showed a constant preoccupation with style. Editors and contributors on both sides of the Atlantic revile unnecessary obscurity and complexity and the use of jargon, barbarisms, vogue words, and weak impersonal constructions. They bewail the pompous use of verbiage and the "medspeak" typified by acronyms and neologisms created by affixation. Suggestions for possible causes of poor medical style range from editorial demands for compression and a general ignorance of the principles of good writing to faulty logic and the subordination of communication to status seeking. The consequences of bad writing may include the fragmentation of knowledge, an increase in the importance of abstracting services, a trend towards free glossy medical newspapers, and, as remedial measures, workshops and courses in medical writing. Some implications for English language teachers working with foreign medical graduates and preclinical students are discussed. PMID:6414596

  19. Let Us Rank Journalism Programs

    ERIC Educational Resources Information Center

    Weber, Joseph

    2014-01-01

    Unlike law, business, and medical schools, as well as universities in general, journalism schools and journalism programs have rarely been ranked. Publishers such as "U.S. News & World Report," "Forbes," "Bloomberg Businessweek," and "Washington Monthly" do not pay them much mind. What is the best…

  20. Journalism and Institutional Review Boards

    ERIC Educational Resources Information Center

    Dash, Leon

    2007-01-01

    The author opposes any Institutional Review Boards (IRBs) overseeing the work of journalism professors and journalism students in any academic institution. He argues that the tendency for IRBs to require anonymity for persons interviewed immediately reduces the credibility of any journalistic story. The composition of an IRB is questioned on…

  1. Humanities Journals Confront Identity Crisis

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2009-01-01

    Senior scholars, the A-list of academic publishing, seem to submit fewer unsolicited manuscripts to traditional humanities journals than they used to. The journal has become, with very few exceptions, the place where junior and midlevel scholars are placing their work. Technology and changing habits have called into question the nature of the…

  2. The Urbanization of American Journalism.

    ERIC Educational Resources Information Center

    Nord, David Paul

    1992-01-01

    Discusses the changes in journalism occurring during the growth of private enterprise in the United States. Focuses on newspapers in Chicago and other midwestern cities. Describes Joseph Pulitzer's "New York World" as the culmination of the urbanization of U.S. journalism, recognizing the development of public interdependence in a…

  3. Local Evaluation of Chemistry Journals

    ERIC Educational Resources Information Center

    Kraus, Joseph R.; Hansen, Rachel

    2008-01-01

    This paper reports on the evaluation of local usage statistics of a specific set of chemistry journals at the University of Denver in Colorado, USA. The objective of the study is to demonstrate that commercial publishers in chemistry charge considerably more for their journals than those from the non-commercial sector. There are three variables…

  4. THE Journal's 2007 Innovators: 1

    ERIC Educational Resources Information Center

    T.H.E. Journal, 2007

    2007-01-01

    Through a variety of efforts large and small, across schools, districts, and even oceans, educators are making teaching and learning alive through the pioneering use of technology. Together, they are "T.H.E. Journal"'s class of 2007 Innovators. This article presents the class of 2007 Innovators along with their profiles. They are: (1) Edith…

  5. Email Journaling for Teacher Candidates

    ERIC Educational Resources Information Center

    Jenny, Geraldine Covert

    2005-01-01

    This paper discusses email journaling for those hoping to become a teacher. The author discusses an innovative format she designed for journal entries that revolutionized her field experience supervision practices and those of other supervisors with whom she has shared this format. It has vastly improved the quality of the teacher-candidate's…

  6. Pacific Educational Research Journal, 1996.

    ERIC Educational Resources Information Center

    Berg, Kathleen F., Ed.; Lai, Morris K., Ed.

    1996-01-01

    This first issue of the new "Pacific Educational Research Journal" offers articles covering diverse subjects and using diverse research methods. The new journal represents a rejuvenation of a previous publication to address educational issues specific to the Pacific region. Ethnic groups specifically addressed include Hawaiians,…

  7. Student Journal Writing in Science.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Journal writing in science can be productive and stress basic skills. Students need to be highly motivated to engage in journal writing, and since the world of science fascinates most learners, chances for motivation are good. The subject matter to be written about needs to relate directly to the ongoing unit of study. Dramatizations, both formal…

  8. Price Discrimination in Academic Journals.

    ERIC Educational Resources Information Center

    Joyce, Patrick; Merz, Thomas E.

    1985-01-01

    Analysis of price discrimination (charging different prices to different customers for same product) for 89 academic journals in 6 disciplines reveals: incidence of price discrimination rose between 1974 and 1984, increase in mean institutional (library) subscription price exceeded increase in mean individual subscription price. Journal list…

  9. Comparative effectiveness research: challenges for medical journals.

    PubMed

    Sox, Harold C; Helfand, Mark; Grimshaw, Jeremy; Dickersin, Kay; Tovey, David; Knottnerus, J André; Tugwell, Peter

    2010-04-28

    Editors from a number of medical journals lay out principles for journals considering publication of Comparative Effectiveness Research (CER). In order to encourage dissemination of this editorial, this article is freely available in PLoS Medicine and will be also published in Medical Decision Making, Croatian Medical Journal, The Cochrane Library, Trials, The American Journal of Managed Care, and Journal of Clinical Epidemiology.

  10. Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats.

    PubMed

    Möller, Frank Josef; Pemp, Daniela; Soukup, Sebastian T; Wende, Kathleen; Zhang, Xiajie; Zierau, Oliver; Muders, Michael H; Bosland, Maarten C; Kulling, Sabine E; Lehmann, Leane; Vollmer, Günter

    2016-08-01

    There is an ongoing debate whether the intake of soy-derived isoflavones (sISO) mediates beneficial or adverse effects with regard to breast cancer risk. Therefore, we investigated whether nutritional exposure to a sISO-enriched diet from conception until adulthood impacts on 17β-estradiol (E2)-induced carcinogenesis in the rat mammary gland (MG). August-Copenhagen-Irish (ACI) rats were exposed to dietary sISO from conception until postnatal day 285. Silastic tubes containing E2 were used to induce MG tumorigenesis. Body weight, food intake, and tumor growth were recorded weekly. At necropsy, the number, position, size, and weight of each tumor were determined. Plasma samples underwent sISO analysis, and the morphology of MG was analyzed. Tumor incidence and multiplicity were reduced by 20 and 56 %, respectively, in the sISO-exposed rats compared to the control rats. Time-to-tumor onset was shortened from 25 to 20 weeks, and larger tumors developed in the sISO-exposed rats. The histological phenotype of the MG tumors was independent of the sISO diet received, and it included both comedo and cribriform phenotypes. Morphological analyses of the whole-mounted MGs also showed no diet-dependent differences. Lifelong exposure to sISO reduced the overall incidence of MG carcinomas in ACI rats, although the time-to-tumor was significantly shortened.

  11. Identification and characterization of a novel water-deficit-suppressed gene OsARD encoding an aci-reductone-dioxygenase-like protein in rice.

    PubMed

    Lin, Tao; He, Xiaowei; Yang, Ling; Shou, Huixia; Wu, Ping

    2005-10-24

    The aci-reductone dioxygenase (ARD) family common to bacteria, plants and animals is involved in the methionine salvage pathway. A water-deficit-suppressed gene, OsARD encoding an aci-reductone-dioxygenase-like protein, was identified from rice (Oryza sativa L.). Northern blot and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the OsARD expression is regulated by abiotic stresses and phytohormones. OsARD was mainly expressed in roots under flood conditions. It was suppressed by abiotic stresses including water deficit, high salinity and low temperature, and induced by ethylene and gibberellin acid (GA). Our results showed that the genes for S-adenosylmethionine (SAM) synthase and 1-aminocyclopropane-1-carboxylic acid (ACC) synthase were upregulated in RNA-interference (RNAi) transgenic rice plants with a significant reduction of OsARD expression. Furthermore, the expression of two genes for ethylene signal transduction, ETR2 and EIN3, increased in these RNAi transgenic plants, whereas the expression of ERF3 was suppressed. These results suggest that OsARD may play a role in the metabolism of methionine and ethylene in response to abiotic stresses.

  12. Black agouti (ACI) rats show greater drug- and cue-induced reinstatement of methamphetamine-seeking behavior than Fischer 344 and Lewis rats.

    PubMed

    Xi, Jinlei; Kruzich, Paul J

    2007-05-01

    Fischer 344 (F344) and Lewis (LEW) rats differ in methamphetamine self-administration (SA) and methamphetamine-induced reinstatement of previously extinguished behavior. We sought to determine whether genetic background also influences methamphetamine reinforcement efficacy, conditioned reinstatement, and methamphetamine-primed reinstatement of responding in F344, LEW, and Black Agouti (ACI) rats. We implanted rats with jugular catheters and trained them to self-administer methamphetamine (0.06 mg/kg/infusion) under a progressive ratio (PR) schedule of reinforcement during daily 2-h SA sessions. A compound stimulus (light+tone; LT) was paired with each infusion. Dose-dependent intake was determined for each rat. Rats then entered the extinction phase of the experiment where responding resulted in no programmed consequences. Following extinction sessions, rats underwent conditioned reinstatement testing. For conditioned reinstatement, rats received response-contingent presentations of the LT and no methamphetamine. Last, methamphetamine-primed reinstatement test sessions where conducted where subjects received experimenter delivered infusions of methamphetamine (0.06, 0.12, or 0.24 mg/kg). The strains did not differ in PR responding across the doses tested. The ACI rats demonstrated the highest behavioral output during extinction training, conditioned- and methamphetamine-primed reinstatement of previously extinguished behavior compared to the other strains. These data suggest that genetic background differentially influences extinction, conditioned reinstatement and methamphetamine-primed reinstatement in rats.

  13. Characterization of the expression profile of a wheat aci-reductone-dioxygenase-like gene in response to stripe rust pathogen infection and abiotic stresses.

    PubMed

    Xu, Liangsheng; Jia, Jianguang; Lv, Jie; Liang, Xiaofei; Han, Dejun; Huang, Lili; Kang, Zhensheng

    2010-06-01

    The methionine salvage pathway is conserved from prokaryotes to high eukaryotes. The reaction catalyzed by aci-reductone-dioxygenase (ARD) represents a branch point in the methionine salvage pathway. A novel aci-reductone-dioxygenase gene, designed as TaARD, was identified in a subtraction library constructed with RNA isolated from wheat leaves infected with the stripe rust pathogen. TaARD was predicted to encode a 197 amino acid protein that belongs to the cupin superfamily. In transient expression assays with onion epidermal cells, the TaARD-GFP fusion protein localized to the nucleus and cytoplasm. Southern blot analysis showed that the wheat genome had multiple copies of TaARD. Quantitative real-time RT-PCR (qRT-PCR) analyses revealed that the TaARD transcript was induced in wheat leaves infected with a compatible stripe rust strain. However, its expression was reduced or suppressed in incompatible interactions and by ABA, ethephon (ET), or salicylic acid (SA) treatments. With methyl jasmonate (MeJA) treatment, TaARD transcript level was suppressed in the first 6h but increased afterwards. The expression of TaARD also was inhibited by wounding and environmental stimuli, including high salinity and low temperature. Because of the role of ARD in the methionine salvage pathway, these results suggest that TaARD may be involved in ethylene synthesis and ethylene signaling in response to biotic and abiotic stresses.

  14. Diallyl sulfide induces the expression of estrogen metabolizing genes in the presence and/or absence of diethylstilbestrol in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) induces mammary tumors in female ACI rats and is associated with an increased risk of developing breast cancer in humans. Diallyl sulfide (DAS) has been shown to prevent cancer in animals. Previously, we have shown that DAS inhibits the production of DES induced DNA adducts when given prior to DES. We hypothesize that DAS alters the expression of genes responsible for DES metabolism. To test this hypothesis, four groups of 10 female ACI rats were treated daily for four days as follows: (1) corn oil, (2) 50mg/kg DES, (3) 50mg/kg DAS, and (4) 50mg/kg DAS+50mg/kg DES. RNA was isolated from breast tissue and mRNA levels of CYP1A1, CYP1B1, glutathione-S-transferase (GST) and superoxide dismutase (SOD) were analyzed by real-time PCR. DES, DAS, and DES/DAS treatments increased the expression of CYP1A1 by 2.1-, 4.7-, and 12.7-fold, respectively. Similar results were seen for CYP1B1. DES decreased the expression of GST by 23%, whereas DAS and DAS/DES treatments increased the expression of GST by 12- and 16.7-fold, respectively. Similar results were seen with SOD. These results suggests that DAS may prevent the formation of DES induced DNA damage by altering the expression of DES metabolizing genes.

  15. A new method to estimate photosynthetic parameters through net assimilation rate-intercellular space CO2 concentration (A-Ci ) curve and chlorophyll fluorescence measurements.

    PubMed

    Moualeu-Ngangue, Dany P; Chen, Tsu-Wei; Stützel, Hartmut

    2017-02-01

    Gas exchange (GE) and chlorophyll fluorescence (CF) measurements are widely used to noninvasively study photosynthetic parameters, for example the rates of maximum Rubisco carboxylation (Vcmax ), electron transport rate (J), daytime respiration (Rd ) and mesophyll conductance (gm ). Existing methods for fitting GE data (net assimilation rate-intercellular space CO2 concentration (A-Ci ) curve) are based on two assumptions: gm is unvaried with CO2 concentration in the intercellular space (Ci ); and light absorption (α) and the proportion of quanta absorbed by photosystem II (β) are constant in the data set. These may result in significant bias in estimating photosynthetic parameters. To avoid the above-mentioned hypotheses, we present a new method for fitting A-Ci curves and CF data simultaneously. This method was applied to a data set obtained from cucumber (Cucumis sativus) leaves of various leaf ages and grown under eight different light conditions. The new method had significantly lower root mean square error and a lower rate of failures compared with previously published methods (6.72% versus 24.1%, respectively) and the effect of light conditions on Vcmax and J was better observed. Furthermore, the new method allows the estimation of a new parameter, the fraction of incoming irradiance harvested by photosystem II, and the dependence of gm on Ci .

  16. Journal of Gastric Cancer's Promotion to International Journal from the Perspective of Biliometric Analysis

    PubMed Central

    2016-01-01

    Purpose The aim was to verify if changing the Journal of Gastric Cancer (JGC) to only English (starting in December 2010) was successful based on bibliometrics. Materials and Methods The following indicators were retrieved or calculated from the journal homepage and the Web of Science Core Collection on January 30, 2016: the number of citable articles per year; the number of original articles funded; the national origins of the editorial board members and authors; the total citations; the impact factors; the national origins of authors citing the journal; the source titles of articles citing the journal; and the Hirsch index. Results From 2011 to 2015, the number of citable articles per year was 40, 41, 39, 39, and 40. The proportion of original articles funded was 39 out of 113 articles (34.5%). The editorial board members were from seven countries. The authors were from 11 countries. The total citations increased from 1 in 2011 to 245 in 2015. From 2013 to 2015, the impact factors (without self-citations) were 1.42, 1.36, and 1.60. In 2014, the value 1.60 corresponded to the ranking of 157 out of 210 oncology journals (74.8%); It was cited from 46 countries. Top-ranking countries of citing authors were China (171), Korea (158), and Japan (75). The number of source titles citing the journal was more than 100. The Hirsch index was 12. Conclusions The English-only language policy, which started in December 2010, was successful in promoting the JGC to international levels from the perspective of bibliometric analysis. PMID:27104021

  17. The New Journalism in Historical Perspective

    ERIC Educational Resources Information Center

    Jensen, Jay

    1974-01-01

    Traces the history of new journalism to the pre-Civil War era of partisan and advocacy journalism and points out that "new" types of reporting have occurred throughout the history of American journalism. (RB)

  18. Leading articles in medical journals in 1966.

    PubMed

    Stimpson, Philippa J; Marks, Daniel Jb

    2016-10-01

    The British Journal of Hospital Medicine is 50 years old. This article takes a look back at articles published during the year of its inception from the British Medical Journal, the Lancet and the Journal of the American Medical Association.

  19. Authorship policies of scientific journals.

    PubMed

    Resnik, David B; Tyler, Ana M; Black, Jennifer R; Kissling, Grace

    2016-03-01

    We analysed the authorship policies of a random sample of 600 journals from the Journal Citation Reports database. 62.5% of the journals we sampled had an authorship policy. Having an authorship policy was positively associated with impact factor. Journals from the biomedical sciences and social sciences/humanities were more likely to have an authorship policy than journals from the physical sciences, engineering or mathematical sciences. Among journals with a policy, the most frequent type of policy was guidance on criteria for authorship (99.7%); followed by guidance on acknowledgments (97.3%); requiring that authors make substantial contributions to the research (94.7%); requiring that authors be accountable for the research as a whole (84.8%); guidance on changes in authorship (77.9%); requiring that authors give final approval to the manuscript (77.6%); requiring that authors draft or critically revise the manuscript (71.7%); providing guidance on corporate authorship (58.9%); prohibiting gift, guest or ghost authorship (31.7%); requiring authors to describe their contributions (5.3%); limiting the number of authors for some types of articles (4.0%) and requiring authors to be accountable for their part in the research (1.1%). None of the policies addressed equal contribution statements. Journals that do not have authorship policies should consider adopting or developing ones.

  20. Authorship policies of scientific journals

    PubMed Central

    Resnik, David B; Tyle, Ana M; Black, Jennifer R; Kissling, Grace

    2016-01-01

    We analysed the authorship policies of a random sample of 600 journals from the Journal Citation Reports database. 62.5% of the journals we sampled had an authorship policy. Having an authorship policy was positively associated with impact factor. Journals from the biomedical sciences and social sciences/humanities were more likely to have an authorship policy than journals from the physical sciences, engineering or mathematical sciences. Among journals with a policy, the most frequent type of policy was guidance on criteria for authorship (99.7%); followed by guidance on acknowledgments (97.3%); requiring that authors make substantial contributions to the research (94.7%); requiring that authors be accountable for the research as a whole (84.8%); guidance on changes in authorship (77.9%); requiring that authors give final approval to the manuscript (77.6%); requiring that authors draft or critically revise the manuscript (71.7%); providing guidance on corporate authorship (58.9%); prohibiting gift, guest or ghost authorship (31.7%); requiring authors to describe their contributions (5.3%); limiting the number of authors for some types of articles (4.0%) and requiring authors to be accountable for their part in the research (1.1%). None of the policies addressed equal contribution statements. Journals that do not have authorship policies should consider adopting or developing ones. PMID:26714812

  1. The Electronic Astrophysical Journal Letters Project

    NASA Astrophysics Data System (ADS)

    Dalterio, H. J.; Boyce, P. B.; Biemesderfer, C.; Warnock, A., III; Owens, E.; Fullton, J.

    The American Astronomical Society has developed a comprehensive system for the electronic dissemination of refereed astronomical research results. Our current focus is the production of an electronic version of the Astrophysical Journal Letters. With the help of a recent National Science Foundation grant, we have developed a system that includes: LATEX-based manuscript preparation, electronic submission, peer review, production, development of a database of SGML-tagged manuscripts, collection of page charges and other fees, and electronic manuscript storage and delivery. Delivery options include World-Wide Web access through HTML browsers such as Mosaic and Netscape, an email gateway, and a stand-alone client accessible through astronomical software packages such as IRAF. Our goal is to increase the access and usefulness of the journal by providing enhanced features such as faster publication, advanced search capabilities, forward and backward referencing, links to underlying data and links to adjunct materials in a variety of media. We have based our journal on open standards and freely available network tools wherever possible.

  2. Society Girl, Sob Sister, Journalism Educator: Mary Paxton Keeley, the First Woman Graduate of the School of Journalism at the University of Missouri.

    ERIC Educational Resources Information Center

    Zang, Barbara

    Based on an examination of well-kept primary source material, this paper presents a personal and professional history of Mary Paxton Keeley, the first woman graduate of one of the first journalism schools in the United States, the School of Journalism at the University of Missouri. Starting with her early years, the paper explains that Keeley was…

  3. African Passages: Journaling through Archetypes.

    ERIC Educational Resources Information Center

    Spencer, Patricia

    1990-01-01

    Explores how students (through an awareness of literary archetypes and journal writing) can use African stories to cross cultures, time, and continents, making connections between their worlds and the worlds of others. (MG)

  4. Journalism Program to Fill Gap

    ERIC Educational Resources Information Center

    Goodman, Henry

    1970-01-01

    The preparation of interested and well-trained individuals for service in editorial, advertising, and management positions on rural and small town newspapers is the intent of Sampson Technical Institute's 2-year pilot journalism program. (JO)

  5. An Overview and Analysis of Journal Operations, Journal Publication Patterns, and Journal Impact in School Psychology and Related Fields

    ERIC Educational Resources Information Center

    Floyd, Randy G.; Cooley, Kathryn M.; Arnett, James E.; Fagan, Thomas K.; Mercer, Sterett H.; Hingle, Christine

    2011-01-01

    This article describes the results of three studies designed to understand better the journal operations, publishing practices, and impact of school psychology journals in recent years. The first study presents the results of a survey focusing on journal operations and peer-review practices that was completed by 61 journal editors of school…

  6. The Journal, the Internet, and Teaching

    NASA Astrophysics Data System (ADS)

    Lagowski, J. J.

    1995-11-01

    With this issue, the Journal begins to create an access to the Internet. Our future on the Internet will be achieved systematically, and it will be designed to compliment--add value to--the print Journal. Our Internet connection must be useful to our readers in ways not possible with the print Journal, however, economic considerations cannot be ignored. It would be intellectually and economically unacceptable to produce only a direct copy of theJournal for electronic distribution. The Internet--the information super highway--has been hailed by many as an important information source in the educational process and will become increasingly so in the future. Indeed, there are extant descriptions of apparently innovative uses of modern interactive communications technologies in the education of scientists at the undergraduate level. However, anyone who has attempted to obtain information from the Internet knows that you are as likely to find garbage as you are to find quality information. Webster tells us that garbage is "worthless or nonsensical matter; rubbish; inferior or offensive material; incorrect, meaningless, or unwanted information." An eye for discrimination, which is often a reflection of maturity, is essential when using the current Internet. In other words, because a bit of information appears on the Internet does not ensure its quality. Only in cases where the information sought has its source in a review-oriented process, e.g., from library holdings, can the information on the Internet be trusted. The Internet is fast becoming a "vanity press," where anything can be published with virtually no critique regarding the quality and accuracy of the content. Indeed, it is not necessarily true that the person to whom a bit of information is attributed is the person who posted it. A bit of information on the Internet lies there until someone comes across it and uses it (or links to it), forming a nucleus for further growth. Further growth may center about

  7. An isomer-specific study of solid nitromethane decomposition pathways - Detection of aci-nitromethane (H2CNO(OH)) and nitrosomethanol (HOCH2NO) intermediates

    NASA Astrophysics Data System (ADS)

    Maksyutenko, Pavlo; Förstel, Marko; Crandall, Parker; Sun, Bing-Jian; Wu, Mei-Hung; Chang, Agnes H. H.; Kaiser, Ralf I.

    2016-08-01

    An isomer specific study of energetic electron exposed nitromethane ices was performed via photoionization - reflectron time of flight mass spectrometry (PI-ReTOF-MS) of the subliming products employing tunable vacuum ultraviolet light for ionization. Supported by electronic structure calculations, nitromethane (CH3NO2) was found to isomerize to methyl nitrite (CH3ONO) and also via hydrogen migration to the hitherto elusive aci-nitromethane isomer (H2CNO(OH)). The latter isomerizes to nitrosomethanol (HOCH2NO) through hydroxyl group (OH) migration, and, probably, ring closure to the cyclic 2-hydroxy-oxaziridine isomer (c-H2CON(OH)) as well. The importance of hydrogen migrations was also verified via the nitrosomethane (CH3NO) - formaldehyde oxime isomer (CH2NOH) pair.

  8. Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences.

    PubMed

    Patra, Biswanath; Overstreet, David H; Rezvani, Amir H; Cleves, Mario; Parsian, Abbas

    2007-02-12

    Ethanol associated addictive behaviors are governed by a combination of multiple gene action (polygenic or quantitative trait) and environmental factors. We produced F2 progeny from F1 crosses derived from the alcohol-preferring Fawn-Hooded (FH/Wjd) rat strain and the alcohol-nonpreferring ACI/N strain. We compared different phenotypes related to alcohol intake in more than 600 F2 progeny. We found that female rats had significantly higher mean voluntary and forced ethanol, water, saccharin and total fluid intakes than male rats. Therefore, we compared these measures in the top 15th percentile with those in bottom 15th percentile of the F2 total ethanol intake distribution separately for males and females. The two tail comparison of means showed that only the trait of alcohol preference differed significantly in both males and females, suggesting that alcohol preference is closely related to alcohol intake. Because of the detailed information about the F1 parents of the F2 progeny, it was possible to determine parental effects. For swim test immobility, for example, the F2 progeny derived from FA(m)/FA(f) parents (ACI maternal inheritance) had the lowest mean value of 130s while the F2 progeny from AF/AF parents (FH maternal inheritance) had the highest mean value of 157s (p<0.005). The F2 progeny derived from FA/AF parents (FH maternal inheritance) showed higher mean values of forced alcohol intake than FA/FA parents (FH paternal inheritance) (6.58 and 6.36g/kg/day, respectively) suggesting that the FH mother had a significantly (p<0.0001) greater effect on forced alcohol intake than the FH father. It is concluded from these analyses that alcohol-related phenotypes are segregating independently and may be influenced by maternal and sex factors.

  9. Effects of acute dopaminergic and serotonergic manipulations in the ACI paradigm depend on the basal valence of cognitive judgement bias in rats.

    PubMed

    Golebiowska, Joanna; Rygula, Rafal

    2017-02-14

    Recent findings have revealed that pharmacological enhancement of dopaminergic (DA) function by the administration of a DA precursor (dihydroxy-L-phenylalanine; L-DOPA), but not the selective serotonin reuptake inhibitor (SSRI) citalopram, increases an optimism bias in humans. To test whether dopamine might play a similar role in non-human animals, in the present study, we evaluated the effects of acute injections of L-DOPA, the D2 receptor antagonist haloperidol, and the SSRI escitalopram on cognitive judgement bias of rats in the ambiguous-cue interpretation (ACI) paradigm. Three different doses of each drug were administered in a fully randomised Latin-square design, along with saline treatment as a control, 30minutes before the ACI tests. Initial analysis revealed that only animals treated with L-DOPA were more 'pessimistic' than the saline-treated controls. Neither haloperidol nor escitalopram significantly affected the cognitive judgement bias of rats. However, further analysis revealed that the effects of the tested compounds might depend on the basal cognitive judgement bias of the tested animals. When we divided the rats into 'optimistic' and 'pessimistic' groups based on their cognitive judgement bias in the drug-free state, it turned out that acute administration of L-DOPA caused a 'pessimistic' shift in 'optimistic' animals while showing no significant effects on 'pessimists'. Acute administration of haloperidol caused a 'pessimistic' shift in 'optimistic' animals and an 'optimistic' shift in 'pessimists'. Acute administration of escitalopram caused a 'pessimistic' shift in 'optimistic' animals and had no significant effects on 'pessimists', except that the middle tested dose rendered the rats more 'optimistic'.

  10. Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats.

    PubMed

    Kutanzi, Kristy; Kovalchuk, Olga

    2013-07-01

    The impact of environmental mutagens and carcinogens on the mammary gland has recently received a lot of attention. Among the most generally accepted carcinogenic agents identified as factors that may increase breast cancer incidence are ionizing radiation and elevated estrogen levels. However, the molecular mechanisms of mammary gland aberrations associated with radiation and estrogen exposure still need to be further elucidated, especially the interplay between elevated hormone levels and radiation. Therefore, in the present study, we investigated molecular changes induced in rat mammary gland tissue by estrogen, ionizing radiation, and the combined action of these two carcinogens using a well-established ACI rat model. We found that continuous exposure of intact female ACI rats to elevated levels of estrogen or to both estrogen and radiation resulted in significant hyperproliferative changes in rat mammary glands. In contrast, radiation exposure alone did not induce hyperplasia. Interestingly, despite the obvious disparity in mammary gland morphology, we did not detect significant differences in the levels of genomic methylation among animals exposed to estrogen, radiation, or both agents together. Specifically, we observed a significant global genomic hypomethylation at 6 weeks of exposure. However, by 12 and 18 weeks, the levels of global DNA methylation returned to those of age-matched controls. We also found that combined exposure to radiation and estrogen significantly altered the levels of histone H3 and H4 methylation and acetylation. Most importantly, we for the first time demonstrated that estrogen and radiation exposure caused a significant induction of p42/44 MAPK and p38 pathways that was paralleled by elevated levels of H3S10 phosphorylation, a well-established biomarker of genome and chromosome instability. The precise role of MAPK pathways and their inter-relationship with H3S10 phosphorylation and genome instability in mammary gland tissues needs

  11. The Therapeutic Use of Journaling with Adolescents

    ERIC Educational Resources Information Center

    Utley, Allison; Garza, Yvonne

    2011-01-01

    In this article, we discuss and provide an example of journaling in the context of counseling, focusing on its application with adolescents. A script to be read by the therapist is included with prompts for self-reflection and journaling by the client. The excerpts presented are the actual journal reflections taken from a teenager's journal. The…

  12. Crossing Cultures with Multi-Voiced Journals

    ERIC Educational Resources Information Center

    Styslinger, Mary E.; Whisenant, Alison

    2004-01-01

    In this article, the authors discuss the benefits of using multi-voiced journals as a teaching strategy in reading instruction. Multi-voiced journals, an adaptation of dual-voiced journals, encourage responses to reading in varied, cultured voices of characters. It is similar to reading journals in that they prod students to connect to the lives…

  13. Creativity and Mathematics: Using Learning Journals

    ERIC Educational Resources Information Center

    Coles, Alf; Banfield, Gemma

    2012-01-01

    Does the term "learning journal" readily conjure up an image of something that is part of the normal mathematics classroom? Personally, do you ever use a journal of some form to help you organise your thoughts? Or, put quite simply--what is a learning journal? It might be that you are unfamiliar with the label, but journals are one type of…

  14. Relative Influence of Professional Counseling Journals

    ERIC Educational Resources Information Center

    Fernando, Delini M.; Barrio Minton, Casey A.

    2011-01-01

    The authors used social network analysis of citation data to study the flow of information and relative influence of 17 professional counseling journals. Although the "Journal of Counseling & Development" ranked very highly in all measures of journal influence, several division journals emerged as key players in the flow of information within the…

  15. The Core Journal Concept in Black Studies

    ERIC Educational Resources Information Center

    Weissinger, Thomas

    2010-01-01

    Black Studies scholars have shown interest in the core journal concept. Indeed, the idea of core journals for the study of the Black experience has changed several times since 1940. While Black Studies scholars are citing Black Studies journals with frequency, they also cite traditional disciplinary journals a great deal of the time. However,…

  16. Impact of Electronic Publishing on Scholarly Journals.

    ERIC Educational Resources Information Center

    Koch, H. William

    Three general features of scholarly journals--internal processing, format, and form--are examined with regard to journals published by the American Institute of Physics (AIP). Reasons for the minor impact of electronic processing on output forms and display formats in physics journals are discussed, including the dependence of such journals on the…

  17. Informational Dynamics of Journal Article Titles.

    ERIC Educational Resources Information Center

    Diener, Richard A. V.

    1984-01-01

    Analyzes changing information values of journal article titles (measured by counting total number of words, number of keywords, and computing proportion of substantive words). Use of linear regression to determine change patterns for sample of titles from four selected journals, six library journals, and six miscellaneous journals (1951-1980) is…

  18. Magazine Educators Consider "Service Journalism" Orientation.

    ERIC Educational Resources Information Center

    Jeffers, Dennis W.

    1990-01-01

    Summarizes the debate within magazine journalism education over how much attention to devote to "service journalism," which encompasses informative, how-to articles. Surveys readers of "Angus Journal," a beef industry journal. Suggests a reader preference for service articles over news and human interest content. Reviews the…

  19. Women's Participation in Behavioral and APA Journals.

    ERIC Educational Resources Information Center

    Morris, Edward K.; And Others

    Concern about the professional socialization of women in academic positions has increased markedly in recent years. This study examined women's participation in behavioral journals and journals published by the American Psychological Association (APA) in terms of journal authorship and the composition of journal editorial boards. Behavioral…

  20. Exploring between Two Worlds: China's Journalism Education.

    ERIC Educational Resources Information Center

    Xiaoming, Hao; Xiaoge, Xu

    1997-01-01

    Examines the historical developments of China's journalism education and its current exploration for a new path. Notes that, despite a history of close to 80 years, China's journalism education has yet to make a substantial impact on journalism practice. Concludes that China's journalism education is unique in that it combines elements of Soviet…

  1. American Journalism Textbooks and Social Responsibility.

    ERIC Educational Resources Information Center

    McConnell, Jane S.

    1999-01-01

    Examines 12 journalism textbooks published from 1891 to 1942, showing how their changes parallel changes in journalism and society. Provides insights into the authors' perceptions of the proper role of journalism in society, and documents changes in the way press responsibility was viewed by journalism educators and professionals. (SR)

  2. Chinese Journalism Education: Slow Progress since 1918.

    ERIC Educational Resources Information Center

    Jingming, Zhang; Jiana, Peng

    1986-01-01

    Notes that journalism education prior to 1949 was modeled after American journalism schools, while since the 1950s, that orientation has been replaced by Soviet principles. Observes the projected shortage of journalism graduates and the need for increased capacity in journalism institutions and for increased international exchange. (HTH)

  3. The "Crane Problem" in Journalism Historiography.

    ERIC Educational Resources Information Center

    Marmarelli, Ron

    Attempting to correct and amplify the portrayal of Stephen Crane in journalism history, this paper provides an analysis of relevant works in journalism and other disciplines in order to point out the weaknesses in the journalism historiography and to show how they apparently came about. Evidence is presented from the literature of journalism,…

  4. Faculty Perception of Business Education Journals.

    ERIC Educational Resources Information Center

    Blair, Robert B.; Balachandran, Martha E.

    2002-01-01

    Responses from 51 of 134 members of the National Association of Business Teacher Education (NABTE) rated the quality of 22 business education journals. The top two were Delta Pi Epsilon Journal and NABTE Review. Refereed and national publications rated higher than nonrefereed or state journals. Most departments did not rank journals in the…

  5. The Relationship between Journal Productivity and Obsolescence.

    ERIC Educational Resources Information Center

    Wallace, Danny P.

    1986-01-01

    Examines relationship between journal productivity (number of references to particular journal) and journal obsolescence (median age of references to particular journal) for database of references dealing with desalination. Citation age by Bradford zones, continuous measurement of productivity and citation age, and underlying structure of observed…

  6. Journal Sheets in the Choral Rehearsal.

    ERIC Educational Resources Information Center

    Kassler, David J.

    2001-01-01

    Discusses the use of journal sheets with choral students. Addresses the benefits of journal sheets, such as providing a means to determine the level of students' critical thinking skills or as a way to reinforce concepts. Includes a copy of a journal sheet and journal sheet responses from choral students. (CMK)

  7. What do evidence-based secondary journals tell us about the publication of clinically important articles in primary healthcare journals?

    PubMed Central

    McKibbon, Kathleen Ann; Wilczynski, Nancy L; Haynes, Robert Brian

    2004-01-01

    Background We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. Methods We performed an analytic survey of a hand search of 170 general medicine, general healthcare, and specialty journals for 2000. Research staff assessed individual articles by using explicit criteria for scientific merit for healthcare application. Practitioners assessed the clinical importance of these articles. Outcome measures were the number of high-quality, clinically relevant studies published in the 170 journal titles and how many of these were published in each of four discipline-specific, secondary "evidence-based" journals (ACP Journal Club for internal medicine and its subspecialties; Evidence-Based Medicine for general/family practice; Evidence-Based Nursing for general practice nursing; and Evidence-Based Mental Health for all aspects of mental health). Original studies and review articles were classified for purpose: therapy and prevention, screening and diagnosis, prognosis, etiology and harm, economics and cost, clinical prediction guides, and qualitative studies. Results We evaluated 60,352 articles from 170 journal titles. The pass criteria of high-quality methods and clinically relevant material were met by 3059 original articles and 1073 review articles. For ACP Journal Club (internal medicine), four titles supplied 56.5% of the articles and 27 titles supplied the other 43.5%. For Evidence-Based Medicine (general/family practice), five titles supplied 50.7% of the articles and 40 titles supplied the remaining 49.3%. For Evidence-Based Nursing (general practice nursing), seven titles supplied 51.0% of the articles and 34 additional titles supplied 49.0%. For Evidence-Based Mental Health (mental health), nine titles supplied 53.2% of the articles and 34 additional

  8. Materials

    NASA Technical Reports Server (NTRS)

    Glaessgen, Edward H.; Schoeppner, Gregory A.

    2006-01-01

    NASA Langley Research Center has successfully developed an electron beam freeform fabrication (EBF3) process, a rapid metal deposition process that works efficiently with a variety of weldable alloys. The EBF3 process can be used to build a complex, unitized part in a layer-additive fashion, although the more immediate payoff is for use as a manufacturing process for adding details to components fabricated from simplified castings and forgings or plate products. The EBF3 process produces structural metallic parts with strengths comparable to that of wrought product forms and has been demonstrated on aluminum, titanium, and nickel-based alloys to date. The EBF3 process introduces metal wire feedstock into a molten pool that is created and sustained using a focused electron beam in a vacuum environment. Operation in a vacuum ensures a clean process environment and eliminates the need for a consumable shield gas. Advanced metal manufacturing methods such as EBF3 are being explored for fabrication and repair of aerospace structures, offering potential for improvements in cost, weight, and performance to enhance mission success for aircraft, launch vehicles, and spacecraft. Near-term applications of the EBF3 process are most likely to be implemented for cost reduction and lead time reduction through addition of details onto simplified preforms (casting or forging). This is particularly attractive for components with protruding details that would require a significantly large volume of material to be machined away from an oversized forging, offering significant reductions to the buy-to-fly ratio. Future far-term applications promise improved structural efficiency through reduced weight and improved performance by exploiting the layer-additive nature of the EBF3 process to fabricate tailored unitized structures with functionally graded microstructures and compositions.

  9. C20orf9-003 (ACI-1), a gene localized on chromosome 20q13.12 encoding for a 49 kD cytoplasmic protein with a putative nucleotide binding site.

    PubMed

    Scott, Boyd B; Zaratin, Paola F; Clarke, Geoffrey D; Barnes, Michael R; Murdock, Paul R; Lynch, Frank J; Duckworth, Malcolm

    2004-02-01

    Murine NGD5 is a gene identified from NG108-15 cells which is postulated to be involved in opioid receptor function. Here we report the cloning and characterization of a cDNA C20orf9-003 (ACI-1) encoding the human orthologue of the mouse NGD5. Analysis of the genomic structure revealed that C20orf9-003 (ACI-1) contains 13 exons and 12 introns, spanning 52.5kb of genomic DNA and is a variant of C20orf9. Chromosomal localization of human C20orf9-003 (ACI-1) assigned this gene to chromosome 20q13.12. Genes at this locus have been associated with the progression and possibly the development of various cancers. In addition several linkage studies support the possibility that one or more genes affecting obesity are located in 20q13. No function can be clearly assigned to C20orf9-003 (ACI-1), however, the protein has a cytoplasmic subcellular location and the secondary structure contains a Rossman fold like feature which is found in many nucleotide binding proteins.

  10. Toward Reproducible Computational Research: An Empirical Analysis of Data and Code Policy Adoption by Journals

    PubMed Central

    Stodden, Victoria; Guo, Peixuan; Ma, Zhaokun

    2013-01-01

    Journal policy on research data and code availability is an important part of the ongoing shift toward publishing reproducible computational science. This article extends the literature by studying journal data sharing policies by year (for both 2011 and 2012) for a referent set of 170 journals. We make a further contribution by evaluating code sharing policies, supplemental materials policies, and open access status for these 170 journals for each of 2011 and 2012. We build a predictive model of open data and code policy adoption as a function of impact factor and publisher and find higher impact journals more likely to have open data and code policies and scientific societies more likely to have open data and code policies than commercial publishers. We also find open data policies tend to lead open code policies, and we find no relationship between open data and code policies and either supplemental material policies or open access journal status. Of the journals in this study, 38% had a data policy, 22% had a code policy, and 66% had a supplemental materials policy as of June 2012. This reflects a striking one year increase of 16% in the number of data policies, a 30% increase in code policies, and a 7% increase in the number of supplemental materials policies. We introduce a new dataset to the community that categorizes data and code sharing, supplemental materials, and open access policies in 2011 and 2012 for these 170 journals. PMID:23805293

  11. Toward Reproducible Computational Research: An Empirical Analysis of Data and Code Policy Adoption by Journals.

    PubMed

    Stodden, Victoria; Guo, Peixuan; Ma, Zhaokun

    2013-01-01

    Journal policy on research data and code availability is an important part of the ongoing shift toward publishing reproducible computational science. This article extends the literature by studying journal data sharing policies by year (for both 2011 and 2012) for a referent set of 170 journals. We make a further contribution by evaluating code sharing policies, supplemental materials policies, and open access status for these 170 journals for each of 2011 and 2012. We build a predictive model of open data and code policy adoption as a function of impact factor and publisher and find higher impact journals more likely to have open data and code policies and scientific societies more likely to have open data and code policies than commercial publishers. We also find open data policies tend to lead open code policies, and we find no relationship between open data and code policies and either supplemental material policies or open access journal status. Of the journals in this study, 38% had a data policy, 22% had a code policy, and 66% had a supplemental materials policy as of June 2012. This reflects a striking one year increase of 16% in the number of data policies, a 30% increase in code policies, and a 7% increase in the number of supplemental materials policies. We introduce a new dataset to the community that categorizes data and code sharing, supplemental materials, and open access policies in 2011 and 2012 for these 170 journals.

  12. Journal of Mineralogical and Petrological Sciences

    NASA Astrophysics Data System (ADS)

    Official journal of Japan Association of Mineralogical Sciences (JAMS), focusing on mineralogical and petrological sciences and their related fields. Journal of Mineralogical and Petrological Sciences (JMPS) is the successor journal to both “Journal of Mineralogy, Petrology and Economic Geology” and “Mineralogical Journal”. Journal of Mineralogical and Petrological Sciences (JMPS) is indexed in the ISI database (Thomson Reuters), the Science Citation Index-Expanded, Current Contents/Physical, Chemical & Earth Sciences, and ISI Alerting Services.

  13. Laser Journal (Selected Articles),

    DTIC Science & Technology

    1982-09-10

    OPTICAL PROPERTIES OF SINGLE CRYSTAL SULPHONATED SALICYLIC ACID Wang Gongming, Jiang Xiengmei) Wang Wencheng (Physics Department, Fudan University) A...laser is described. The apparatus structure and some experimental results are reported. MATERIAL AND ELEMENT MAGNETO-OPTIC PROPERTIES OF Pr dYb),(1oAI...Sinica) The 9,,.d of (BiPzGdyb0,(F!AI 1, single crystal thin film at 6328A is as high as 3.69-4.05’/dB . This property has been applied to optical

  14. Dwight D. Eisenhower Army Medical Center (DDEAMC) Staff Preferences: Electronic Journals versus Print Journals

    DTIC Science & Technology

    2003-04-01

    Biomedical Library Journal Preferences 26 investigated the impact of electronic journals on research processes. The results of this research indicated... Library Journal Preferences 28 reported that health science researchers valued the convenience and time-saving features of electronic journals including 24...Health Science Library (2001). Health Science Library Journal List [Brochure]. Fort Gordon, Georgia: Author. Department of Defense (2002). Department

  15. Journal Benchmarking for Strategic Publication Management and for Improving Journal Positioning in the World Ranking Systems

    ERIC Educational Resources Information Center

    Moskovkin, Vladimir M.; Bocharova, Emilia A.; Balashova, Oksana V.

    2014-01-01

    Purpose: The purpose of this paper is to introduce and develop the methodology of journal benchmarking. Design/Methodology/ Approach: The journal benchmarking method is understood to be an analytic procedure of continuous monitoring and comparing of the advance of specific journal(s) against that of competing journals in the same subject area,…

  16. State of the Journal, 2016.

    PubMed

    Richards, Lorie Gage

    The American Journal of Occupational Therapy (AJOT) had a successful 2016. From September 2015 to September 2016, the number of manuscripts submitted remained steady at 255. Manuscripts were received from 30 non-U.S. countries, compared with 23 countries in 2015. AJOT continues to have the highest impact factor and to be the highest ranked of the occupational therapy journals listed in Journal Citation Reports. AJOT continues to focus on publishing research articles on aspects of occupational therapy among varied populations with diverse acute and chronic conditions. Changes in 2016 include requiring authors to register clinical trials at public trial registration sites and welcoming new associate editors and reviewers to the AJOT family.

  17. State of the Journal, 2015.

    PubMed

    Richards, Lorie Gage

    2015-01-01

    The American Journal of Occupational Therapy (AJOT) had a successful 2015. From September 2014 to September 2015, the number of manuscripts submitted had increased by 35%. Manuscripts were received from 23 countries, compared with 17 countries in 2014. AJOT continues to have the highest impact factor and to be the highest ranked of the occupational therapy journals listed in Journal Citation Reports. AJOT continues to focus on publishing research articles on aspects of occupational therapy among varied populations with diverse acute and chronic conditions. Additional changes for 2015 include new associate editors, a significantly enlarged pool of reviewers from across the globe, continuous publishing, pay-per-view, updated author guidelines, and the adoption of clinical trial registration requirements effective January 1, 2016.

  18. Update on inflation of journal prices: medical journals, U.S. journals, and Brandon/Hill list journals.

    PubMed

    Kronenfeld, M R; Gable, S H

    1989-01-01

    This paper examines the increases in prices for the last twenty years for the journals listed in the 1987 Brandon/Hill list and for the last twelve years for those on a list of medical and general periodicals published annually in Library Journal. This information is compared to the general U.S. inflation rate as measured by the Consumer Price Index. Despite the decline in the general rate of inflation, the buying power of libraries has continued to dwindle. Librarians need to use this information when justifying increased budget requests. They also need to interact more effectively with publishers to resolve this problem. The buying power of the dollar (as compared to the 1975 dollar) spent on the Brandon/Hill list journals is now 59% of that of a dollar spent in the general economy. This compares to 64% in 1983, when this research was last updated.

  19. The Journal ? As of Now

    NASA Astrophysics Data System (ADS)

    Kemp, John

    To follow Mike Richey's authoritative article on the launch and subsequent development of the Journal is almost as daunting a task as it has been to follow his thirty-nine years as Editor.My own time in post has amounted to a mere eleven years, a period which I have found both enjoyable and rewarding. Mike set and maintained a very high standard in the content and in the presentation of the Journal. Such was die reputation and the standing of the Journal that few changes were needed, and it was straightforward enough to continue on much the same lines. Straightforward, but not at all easy. It was only when I took over as Editor that I fully appreciated the care and attention to detail that Mike had invested in producing volume after volume to such a consistently high standard. Fortunately I have always had a dedicated and efficient Assistant Editor, most recently, Rebecca Dudley.

  20. Evaluating big deal journal bundles

    PubMed Central

    Bergstrom, Theodore C.; Courant, Paul N.; McAfee, R. Preston; Williams, Michael A.

    2014-01-01

    Large commercial publishers sell bundled online subscriptions to their entire list of academic journals at prices significantly lower than the sum of their á la carte prices. Bundle prices differ drastically between institutions, but they are not publicly posted. The data that we have collected enable us to compare the bundle prices charged by commercial publishers with those of nonprofit societies and to examine the types of price discrimination practiced by commercial and nonprofit journal publishers. This information is of interest to economists who study monopolist pricing, librarians interested in making efficient use of library budgets, and scholars who are interested in the availability of the work that they publish. PMID:24979785

  1. Evaluating big deal journal bundles.

    PubMed

    Bergstrom, Theodore C; Courant, Paul N; McAfee, R Preston; Williams, Michael A

    2014-07-01

    Large commercial publishers sell bundled online subscriptions to their entire list of academic journals at prices significantly lower than the sum of their á la carte prices. Bundle prices differ drastically between institutions, but they are not publicly posted. The data that we have collected enable us to compare the bundle prices charged by commercial publishers with those of nonprofit societies and to examine the types of price discrimination practiced by commercial and nonprofit journal publishers. This information is of interest to economists who study monopolist pricing, librarians interested in making efficient use of library budgets, and scholars who are interested in the availability of the work that they publish.

  2. Quantitative Articles: Developing Studies for Publication in Counseling Journals

    ERIC Educational Resources Information Center

    Trusty, Jerry

    2011-01-01

    This article is presented as a guide for developing quantitative studies and preparing quantitative manuscripts for publication in counseling journals. It is intended as an aid for aspiring authors in conceptualizing studies and formulating valid research designs. Material is presented on choosing variables and measures and on selecting…

  3. The Use of Electric-Only Journals in Scientific Research.

    ERIC Educational Resources Information Center

    Llewellyn, Richard D.; Pellack, Lorraine J.; Shonrock, Diana D.

    2002-01-01

    Discussion of journals that are published exclusively in electronic format focuses on the way they affect the communication of scientific information to the research community. Highlights include the impermanence of electronic materials; access; indexing; library holdings; pricing; cataloging; citations; and considerations for further study.…

  4. From Journals to Journalism: Tracing Trajectories of Literate Development

    ERIC Educational Resources Information Center

    Roozen, Kevin

    2009-01-01

    Drawn from a longitudinal ethnographic study, this article elaborates the trajectories linking one undergraduate's extracurricular journaling to her school writing and her emerging identity as a journalist. This portrait of literate development highlights how our sense of ourselves as literate persons is forged in the interplay of multiple…

  5. Ecological Perspectives on Emotional Disturbance. Journal within a Journal.

    ERIC Educational Resources Information Center

    Chrystal, Charles A., Ed.; And Others

    1988-01-01

    The articles included in this special journal supplement represent a view of special education which is concerned with the adjustment of the emotionally disturbed learner within varied social-interactional frameworks or settings, as noted in the guest editorial by Charles Chrystal. "Beyond Therapy and Research: Helping Emotionally Troubled…

  6. Comparison of Journal Self-Citation Rates between Some Chinese and Non-Chinese International Journals

    PubMed Central

    Yang, Zu-Guo; Gao, Feng; Zhang, Chun-Ting

    2012-01-01

    Background The past 3 decades have witnessed a boost in science development in China; in parallel, more and more Chinese scientific journals are indexed by the Journal Citation Reports issued by Thomson Reuters (SCI). Evaluation of the performance of these Chinese SCI journals is necessary and helpful to improve their quality. This study aimed to evaluate these journals by calculating various journal self-citation rates, which are important parameters influencing a journal impact factor. Methodology/Principal Findings We defined three journal self-citation rates, and studied these rates for 99 Chinese scientific journals, almost exhausting all Chinese SCI journals currently available. Likewise, we selected 99 non-Chinese international (abbreviated as ‘world’) journals, with each being in the same JCR subject category and having similar impact factors as their Chinese counterparts. Generally, Chinese journals tended to be higher in all the three self-citation rates than world journal counterparts. Particularly, a few Chinese scientific journals had much higher self-citation rates. Conclusions/Significance Our results show that generally Chinese scientific journals have higher self-citation rates than those of world journals. Consequently, Chinese scientific journals tend to have lower visibility and are more isolated in the relevant fields. Considering the fact that sciences are rapidly developing in China and so are Chinese scientific journals, we expect that the differences of journal self-citation rates between Chinese and world scientific journals will gradually disappear in the future. Some suggestions to solve the problems are presented. PMID:23173041

  7. An International Journal's Attempts to Address Inequalities in Academic Publishing: Developing a Writing for Publication Programme

    ERIC Educational Resources Information Center

    Lillis, Theresa; Magyar, Anna; Robinson-Pant, Anna

    2010-01-01

    Scholars around the world are under increasing pressure to publish in English, in Anglophone centre journals. At the same time, research on professional academic writing indicates that scholars from outside Anglophone centre contexts face considerable obstacles in getting their academic work published in such journals, relating to material and…

  8. The Language and Literacy Spectrum, 1996. A Journal of the New York State Reading Association.

    ERIC Educational Resources Information Center

    Gormley, Kathleen A., Ed.; McDermott, Peter C., Ed.

    1996-01-01

    Sharing concerns and interests of New York State educators in the improvement of literacy, this annual journal raises educational issues such as current thoughts about literacy instruction, educators' roles, literacy in its many forms, college-community literacy partnerships, and recommended reading materials. Articles in the journal are "Who…

  9. Electronic Journals, Scholarship, and Tenure: Paving the Way for New Policies in Higher Education.

    ERIC Educational Resources Information Center

    Lamphere, Patricia; Reinke, Kathryn; Papanek, Melissa

    This study investigated the beliefs of mathematics educators regarding issues of scholarship and tenure associated with material published in electronic journals on the Internet. Based on 58 responses received through an e-mail survey, the study showed that respondents felt: comparable print and e-journals should garner the same prestige and…

  10. Scholastic Journalism Week, February 21-27, 1993. Celebrating 200 Years, Freedom of the Press.

    ERIC Educational Resources Information Center

    Journalism Education Association.

    Designed to raise community consciousness regarding the benefits of scholastic journalism, this collection of material offers suggestions for celebrating Scholastic Journalism Week. The collection provides: a list of the benefits of high school publications; brief suggestions for 11 school activities; brief descriptions of 10 classroom activities;…

  11. An overview and analysis of journal operations, journal publication patterns, and journal impact in school psychology and related fields.

    PubMed

    Floyd, Randy G; Cooley, Kathryn M; Arnett, James E; Fagan, Thomas K; Mercer, Sterett H; Hingle, Christine

    2011-12-01

    This article describes the results of three studies designed to understand better the journal operations, publishing practices, and impact of school psychology journals in recent years. The first study presents the results of a survey focusing on journal operations and peer-review practices that was completed by 61 journal editors of school psychology and aligned journals. The second study presents the results of review and classification of all articles appearing in one volume year for nine school psychology journals (i.e., The California School Psychologist, Canadian Journal of School Psychology, Journal of Applied School Psychology, Journal of School Psychology, Psychology in the Schools, School Psychology Forum, School Psychology International, School Psychology Quarterly, and School Psychology Review). The third study employed multilevel modeling to investigate differences in the longitudinal trends of impact factor data for five school psychology journals listed in the Web of Science (i.e., Journal of School Psychology, Psychology in the Schools, School Psychology International, School Psychology Quarterly, and School Psychology Review). The article addresses implications for authors, editors, and journal editorial teams as well as the status and impact of school psychology journals.

  12. The Future of Electronic Journals.

    ERIC Educational Resources Information Center

    Varian, Hal R.

    It is widely expected that a great deal of scholarly communication will move to an electronic format. This paper speculates about the impact this movement will have on the form of scholarly communication. In order to understand how journals might evolve, the paper begins with a look at the demand and supply for scholarly commutation today, as well…

  13. Pacific Educational Research Journal, 2000.

    ERIC Educational Resources Information Center

    Berg, Kathleen, Ed.; Lai, Morris, Ed.

    2000-01-01

    This journal features theoretical, empirical, and applied research with implications for and relevance to education in the Pacific area. This volume contains: (1) "Community Perceptions of Culture and Education on Moloka'i" (Lois A. Yamauchi, William L. Greene, Katherine T. Ratliffe, and Andrea K. Ceppi); (2) "Academic Performance…

  14. OATYC Journal, 1993-94.

    ERIC Educational Resources Information Center

    Fullen, Jim, Ed.

    1993-01-01

    Published by the Ohio Association of Two-Year Colleges, this journal is designed to provide a medium for sharing concepts, methods, and findings relevant to the classroom, and an open forum for the discussion and review of problems. Volume XIX consists of the fall 1993 and spring 1994 issues, providing the following articles: (1) "FOCUS: Ohio…

  15. Primary Journal Literature of Physics.

    ERIC Educational Resources Information Center

    Cooper, Marianne; Thayer, Candace W.

    Four hundred and ninety one primary journals covered by "Physics Abstracts" in 1965 have been studied and their basic characteristics analyzed in terms of sponsorship, distribution by country, language, frequency, and coverage by secondary services other than "Physics Abstracts," and the number of libraries holding each…

  16. Professional Journals: Basic Classroom Resource

    ERIC Educational Resources Information Center

    Somerville, Rose M.

    1973-01-01

    This service, offered by The Family Coordinator, is a report of articles found in journals which are not likely to be read regularly but offer an article or special issue of particular usefulness in the family field. Topics included in this issue are paternal rights, student marriages, women's studies, sex, Kibbutz Children, intermarriage and…

  17. OATYC Journal, 1992-1993.

    ERIC Educational Resources Information Center

    Fullen, Jim, Ed.

    1993-01-01

    The OATYC Journal provides the two-year colleges of Ohio with a medium for discussing problems and sharing concepts, methods, and findings relevant to the two-year college classroom. The fall 1992 and spring 1993 issues contain: "What We Are Doing Right: Can We Do It All?," by Linda Houston; "Campus Profile: A Walk through Shawnee…

  18. Transformation and Text: Journal Pedagogy.

    ERIC Educational Resources Information Center

    Ellis, Carol

    One intention that an instructor had for her new course called "Writing and Healing: Women's Journal Writing" was to make apparent the power of self-written text to transform the writer. She asked her students--women studying women writing their lives and women writing their own lives--to write three pages a day and to focus on change.…

  19. WATESOL Journal, 1989-1994.

    ERIC Educational Resources Information Center

    WATESOL Journal, 1994

    1994-01-01

    "WATESOL" is an acronym for "Washington Area Teachers of English To Speakers of Other Languages." This document consists of the only three issues of the "WATESOL Journal" published from 1989 through 1994. Fall 1989 includes: (1) "The Visual Voices of Nonverbal Films" (Salvatore J. Parlato); (2)…

  20. English Teachers' Journal (Israel), 1991.

    ERIC Educational Resources Information Center

    English Teachers' Journal (Israel), 1991

    1991-01-01

    This document consists of the two issues of "English Teachers' Journal (Israel)" issued during 1991. Contents include: "Introduction for English Teachers"; "Announcements for Bagrut Teachers and Examiners"; "News from E.T.A.I. (English Teachers' Association of Israel)" (Ephraim Weintroub); "Learning…

  1. [Publishing models in medical journals].

    PubMed

    Reyes, Humberto B

    2012-02-01

    Medical journals are published by scientific societies, universities, publishing agencies and other for-profit or non-profit organizations. The traditional way to cover the expenses in printed journals has been a "subscribers pay" model. The rise of electronic versions in the internet, either together with the printed version or replacing it entirely, plus a progressive adherence to an "open access" for electronic versions, has created financial difficulties. Therefore, the "authors pay" model has been added. Both models can be subsidized by commercial or institutional advertising, but still a main source for financing relies either in subscriptions or in authors' payments. A small source of income that helps to cover publishing costs is a "charge for manuscript reception", currently applied by several journals. Those authors whose work has institutional or external support can use their grants to cover any charges, but the situation is more difficult for those who do not have such support. Since 1872, Sociedad Médica de Santiago-Chilean Society of Internal Medicine, owner and publisher of Revista Médica de Chile, has employed the "subscribers pay" model, subsidized by commercial advertising and temporary sponsors (Chilean government and others). The printed journal is reproduced in an open access electronic version, in www.scielo.cl. The increasing cost of both publications systems demands a time for reflection.

  2. Correspondence Journals: Talk That Matters

    ERIC Educational Resources Information Center

    Bloem, Patricia L.

    2004-01-01

    Correspondence journals between adults and elementary-school students promote child-centered discussion and learning that is often squeezed out of the curricula. Through an extended example of an exchange of letters between a fifth-grade classroom, including several English-language learners and a university classroom of preservice teachers, the…

  3. Computer Software for Scholastic Journalism.

    ERIC Educational Resources Information Center

    Oates, Rita Haugh

    Four commercially available instructional software programs for high school journalism students are examined in this paper, which also contains suggestions on their use. The four programs reviewed in the paper provide (1) practice in finding the best interview sources in a newsgathering simulation (Super Scoop); (2) review and reinforcement of…

  4. American Educational History Journal, 2001.

    ERIC Educational Resources Information Center

    Watras, Joseph, Ed.

    2001-01-01

    This 2001 annual publication contains 31 articles on topics germane to the history of education. Each year, this journal publishes papers presented at the annual meeting of the Midwest History of Education Society. After the "Introduction" (R. J. Taggart) articles in this year's issue are: "Origins of the American Federation of…

  5. English Teachers' Journal (Israel), 1992.

    ERIC Educational Resources Information Center

    English Teachers' Journal (Israel), 1992

    1992-01-01

    This document consists of the two issues of "English Teachers' Journal (Israel)" issued during 1992. Articles include: "Information for English Teachers"; "Announcements for Bagrut Teachers and Examiners"; "News from Educational Television" (Lily Vered and Others); "News from E.T.A.I. (English Teachers'…

  6. School Library Journal's Spending Survey

    ERIC Educational Resources Information Center

    Farmer, Lesley; Shontz, Marilyn

    2009-01-01

    This year's "School Library Journal's" spending survey showed that, despite the recession, the vast majority of media centers around the country have retained their credentialed media specialists. For example, almost 85% of elementary schools and more than 95% of middle and high schools have a full-time certified librarian. In addition, salaries…

  7. Alabama Counseling Association Journal, 1995.

    ERIC Educational Resources Information Center

    Abbott, Gypsy, Ed.; Elliott, Glenda R., Ed.

    1995-01-01

    Communicating ideas and information that will help counselors to implement the counseling role and develop the profession of counseling is the purpose of this journal. The first issue in volume 21 contains the following articles: "Policies and Procedures for Reporting Child Abuse in Alabama: Considerations for Counselors, Teachers, and School…

  8. Preparing a Research Journal Article.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    1979-01-01

    Discusses how to write a research journal article through a review in three sections: (1) preparing to write, (2) preparing the contents, and (3) evaluating the article. Suggests important questions to be asked when critiquing educational research. Explains the decision-making process used to decide what articles are published. (LRA)

  9. Re-Imagining Education Journalism

    ERIC Educational Resources Information Center

    West, Darrell M.; Whitehurst, Grover J.; Dionne, E.J., Jr.

    2010-01-01

    Education journalism is going through a gut-wrenching transformation of its business model and its organizational structure, even as the ways in which news is delivered are changing rapidly. Old business models have collapsed, and new ones are struggling to find their footing. Digital technologies have fundamentally altered the way news is…

  10. JournalMap: Research. Reimagined.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    JournalMap is a scientific literature search engine that empowers you to find relevant research based on location and biophysical variables as well as traditional keyword searches. All publications are geotagged based on reported location information and plotted on a world map showing where the rese...

  11. Journal of Celtic Language Learning.

    ERIC Educational Resources Information Center

    O Laoire, Muiris, Ed.; Stenson, Nancy, Ed.

    2000-01-01

    This journal is an international review for researchers and teachers of modern Celtic languages. This volume contains seven articles. There are three research articles: "Issues in the Design of Irish Credited Courses" (Thomas W. Ihde); "Learning Irish for Participation in the Irish Language Speech Community outside the…

  12. CACD Journal, 1997-1998.

    ERIC Educational Resources Information Center

    Wickwire, Pat Nellor, Ed.

    1998-01-01

    This issue of the California Association for Counseling and Development Journal reflects connectedness in a world of diversity as its theme. The articles and their authors give witness to the deepening and broadening of status and progress in the counseling profession. The following articles are included: (1) "Caring Schools: An Antidote for…

  13. NTP Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies).

    PubMed

    1988-04-01

    Trichloroethylene is an industrial solvent used primarily for vapor degreasing and cold cleaning. It was selected for study because of its industrial use and for potential for human exposure. (An estimated 3.5 million workers are exposed to trichloroethylene.) In an earlier study trichloroethylene (stabilized with epichlorohydrin and 1,2-epoxybutane) administered by gavage caused hepatocellular carcinomas in male and female B6C3F1 mice. Trichloroethylene administration did not increase the incidence of tumors in male or female Osborne-Mendel rats. However, the survival of dosed rats was reduced, thereby compromising the sensitivity of the study to detect a carcinogenic effect. The studies described in this report were conducted to compare the sensitivities of four strains of rats (ACI, August, Marshall, and Osborne-Mendel) to diisopropylamine-stabilized trichloroethylene. The results of the present studies demonstrate that long-term administration of trichloroethylene produces nephrotoxicity in four strains of rats and that the susceptibilities of these strains to the nephrotoxic effects of the chemical are similar. Because of chemically induced toxicity, reduced survival, and incomplete documentation of the experimental data, the studies are considered inadequate for either comparing or assessing trichloroethylene-induced carcinogenesis in these strains of rats. Toxicology and carcinogenesis studies of trichloroethylene (more than 99% pure, stabilized with 8 ppm diisopropylamine) were conducted by administering the chemical in corn oil gavage at doses of 0, 500, or 1,000 mg/kg per day, 5 day per week, for 103 weeks to groups of 50 male and 50 female ACI, August, Marshall, and Osborne-Mendel rats. The doses were selected on the basis of results from 13-week gavage studies in which groups of 10 male and 10 female ACI, August, and Marshall rats received daily doses or trichloroethylene (male: 125-2,000 mg/kg; female: 63-1,000 mg/kg). Doses for Osborne-Mendel rats

  14. Clinical trial registration in oral health journals.

    PubMed

    Smaïl-Faugeron, V; Fron-Chabouis, H; Durieux, P

    2015-03-01

    Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials.

  15. Use of Journal Citation Reports and Journal Performance Indicators in measuring short and long term journal impact.

    PubMed

    Garfield, E

    2000-12-01

    The impact factor has become the subject of widespread controversy. It has gradually developed to mean both journal and author impact. The emphasis on impact factors obscures the main purpose of bibliographic databases created at the Institute for Scientific Information. I will here show how two of these databases, Journal Citation Reports and the Journal Performance Indicators, can be used to study scientific journals and the articles they publish, as well as the evolution of scientific fields.

  16. Use of standards in papers published in dental journals.

    PubMed

    Bona, Alvaro Della; Bello, Yuri Dal; Sartoretto, Suelen C

    2012-01-01

    This study evaluated the use de standards in papers published in Brazilian and international dental journals. Papers published from January 2006 to December 2010 in the following journals were examined: Brazilian Dental Journal (BDJ), Brazilian Oral Research (BOR), Journal of Applied Oral Sciences (JAOS), Journal of Dental Research (JDR) and Dental Materials (DM). In addition to the title and type of study, issue, volume and year of publication, the following information was recorded from each paper: identification of any standard reported in the study; in case of no reported standard, indication if a standard could be used in the study. A total of 3,046 papers were examined, being 937 from DM, 936 from JDR, 489 from JAOS, 348 from BDJ, and 336 from BOR. Considering the papers that could use some standard, DM showed the highest percentage (24.9%) of reporting standards/paper, followed by JAOS (10.3%), BOR (10.1%), BDJ (6.3%) and JDR (2.4%), meaning for example that, from 936 papers examined from the JDR, 623 could use some standard but only 15 papers reported them. From all papers examined, 309 (10.1%) reported using some standard. The ISO standards were mostly reported (57.8%), followed by ASTM standards (23.7%) and 74 (18.5%) standards from other international organizations (e.g. ADA and CIE). Despite of the high impact factors of the selected dental journals, their published papers could use standards more often. This study should assist journal editors to encourage authors to consult and refer to available standards to support the scientific papers.

  17. The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17beta-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16alpha-hydroxyestradiol, and 4-hydroxyestrone.

    PubMed

    Turan, V K; Sanchez, R I; Li, J J; Li, S A; Reuhl, K R; Thomas, P E; Conney, A H; Gallo, M A; Kauffman, F C; Mesia-Vela, S

    2004-10-01

    Several investigators have suggested that certain hydroxylated metabolites of 17beta-estradiol (E2) are the proximate carcinogens that induce mammary carcinomas in estrogen-sensitive rodent models. The studies reported here were designed to examine the carcinogenic potential of different levels of E2 and the effects of genotoxic metabolites of E2 in an in vivo model sensitive to E2-induced mammary cancer. The potential induction of mammary tumors was determined in female ACI rats subcutaneously implanted with cholesterol pellets containing E2 (1, 2, or 3 mg), or 2-hydroxyestradiol (2-OH E2), 4-hydroxyestradiol (4-OH E2), 16alpha-hydroxyestradiol (16alpha-OH E2), or 4-hydoxyestrone (4-OH E1) (equimolar to 2 mg E2). Treatment with 1, 2, or 3 mg E2 resulted in the first appearance of a mammary tumor between 12 and 17 weeks, and a 50% incidence of mammary tumors was observed at 36, 19, and 18 weeks respectively. The final cumulative mammary tumor incidence in rats treated with 1, 2, or 3 mg E2 for 36 weeks was 50%, 73%, and 100% respectively. Treatment of rats with pellets containing 2-OH E2, 4-OH E2, 16alpha-OH E2, or 4-OH E1 did not induce any detectable mammary tumors. The serum levels of E2 in rats treated with a 1 or 3 mg E2 pellet for 12 weeks was increased 2- to 6-fold above control values (approximately 30 pg/ml). Treatment of rats with E2 enhanced the hepatic microsomal metabolism of E2 to E1, but did not influence the 2- or 4-hydroxylation of E2). In summary, we observed a dose-dependent induction of mammary tumors in female ACI rats treated continuously with E2; however, under these conditions 2-OH E2, 4-OH E2, 16alpha-OH E2, and 4-OH E1 were inactive in inducing mammary tumors.

  18. Editorial: Biotechnology Journal's diverse coverage of biotechnology.

    PubMed

    Wink, Michael

    2014-03-01

    This issue of Biotechnology Journal is a regular issue edited by Prof. Michael Wink. The issue covers all the major focus areas of the journal, including medical biotechnology, synthetic biology, and novel biotechnological methods.

  19. Summary report of journal operations, 2012.

    PubMed

    2013-01-01

    Presents the summary reports of American Psychological Association journal operations (compiled from the 2012 annual reports of the Council of Editors and from Central Office records) and Division journal operations (compiled from the 2012 annual reports of the Division journal editors). The information provided includes number of manuscripts, printed pages, and print subscriptions per journal. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  20. Journal Writing: Enlivening Elementary Linear Algebra.

    ERIC Educational Resources Information Center

    Meel, David E.

    1999-01-01

    Examines the various issues surrounding the implementation of journal writing in an undergraduate linear algebra course. Identifies the benefits of incorporating journal writing into an undergraduate mathematics course, which are supported with students' comments from their journals and their reflections on the process. Contains 14 references.…

  1. Facilitating Student Learning through Math Journals.

    ERIC Educational Resources Information Center

    Koirala, Hari P.

    In the last two decades, mathematics teachers have shown a great deal of interest in how students learn mathematics through journal writing. I have also used journals in mathematics classes for the last five years. Based on the analysis of more than 1800 journal entries written by approximately 200 students in the last five years, I conclude that…

  2. Reflective Journals: A Review of the Literature

    ERIC Educational Resources Information Center

    Lindroth, James T.

    2015-01-01

    The use of reflective journals has been identified as an effective tool to promote reflection in preservice teachers. This review of literature provides the reader with an understanding of the various ways journals are used and assessed in teacher education programs. The findings of this review outline the use of reflective journals on topics such…

  3. Economics of Primary Journals in Physics.

    ERIC Educational Resources Information Center

    Koch, H. William

    The American Institute of Physics (AIP) publishes 87% of the primary research journals in the discipline of physics in the United States. These journals have provided an indispensable communication mechanism for research results and education in physics and astronomy. A redesign of the present journal system is required because of expansions in…

  4. Journaling: A Bridge between School and Home

    ERIC Educational Resources Information Center

    McGough, Julie

    2013-01-01

    This article describes how first-grade students create meaningful communication with families and help build the student-teacher-parent relationship through journaling. Journals are a useful tool to bridge school and home. A journal can communicate learning goals, develop scientific vocabulary, and create dialogue through oral and written…

  5. ICT Use by Journalism Professors in Colombia

    ERIC Educational Resources Information Center

    Hung, Elias Said

    2011-01-01

    This article analyses how journalism professors at Colombian universities use information and communications technologies (ICT) in their teaching. Survey data was obtained during the first trimester of 2009 from 63 professors in journalism departments and from a total of 865 professors who are affiliated with journalism departments at 29…

  6. AsMA journal covers, a history.

    PubMed

    Day, Pamela C

    2014-01-01

    The cover of our journal has changed quite often over the years. As we look forward to changing the name and design of the journal, it seems appropriate to reflect on the previous journal titles and covers. A brief history follows.

  7. Tocqueville, Garrison, and the Perfection of Journalism.

    ERIC Educational Resources Information Center

    Nord, David Paul

    The 1830s marked a lush first flowering of democratic journalism in America--participatory journalism of the sort that Alexis de Tocqueville heralded. But contrary to standard journalism history, this democratic press had nothing to do with the rise of the penny press; in fact, William Lloyd Garrison's abolitionist paper, "The…

  8. The Art of Reviewing Science Journals

    ERIC Educational Resources Information Center

    Shepardson, Daniel P.; Britsch, Susan Jane

    2004-01-01

    Science journals are wonderful tools. They offer a glimpse into children's science understandings, and they are both diagnostic and pedagogically informative to teachers. Examining and reflecting on children's journal work lets teachers embed assessment in curriculum and instruction; however, effectively analyzing children's journal writing and…

  9. Hands-On Science. Journals of Science.

    ERIC Educational Resources Information Center

    Kepler, Lynne

    1998-01-01

    Describes how to use journal writing in elementary science classes. Writing lets children communicate observations and ideas while reinforcing understanding of key science concepts. Journal ideas include using notebooks to respond to teacher prompts or write about what students are studying; sharing a classroom science journal; and keeping a…

  10. Scholarly Electronic Journals: Economic and Technical Issues.

    ERIC Educational Resources Information Center

    Ganesh, Tirupalavanam G.; Glass, Gene V.; Andrews, Sandra; Middleton, James A.; Jennings, Tara A.; Leavy, Aisling

    This paper discusses scholarly communication and the emergence of electronic journals. Scholarly electronic journals are expanding their influence. Currently, about 70 peer-reviewed scholarly journals in education are freely available through the World Wide Web. Wider access to scholarship, new possibilities inherent in the electronic medium, and…

  11. Trends in University Support of Scholastic Journalism.

    ERIC Educational Resources Information Center

    Dickson, Tom

    2001-01-01

    Attempts to determine whether journalism and mass communication programs have become less involved in scholastic journalism in recent years. Finds that media-related units with graduate programs are more sensitive to the needs of teachers. Supports the hypothesis that education for scholastic journalism could be at risk, at least in regard to…

  12. The Economics of Professional Journal Pricing.

    ERIC Educational Resources Information Center

    Stoller, Michael A.; And Others

    1996-01-01

    Evaluates the literature on journal pricing that emphasizes three types of price discrimination practiced by publishers. Concludes that the monopoly power of commercial publishers and a third party payment system are the cause of increasing journal costs. Recommends incentives to journal users, adoption of equitable pricing systems, and employing…

  13. Reporting Characteristics of Cancer Pain: A Systematic Review and Quantitative Analysis of Research Publications in Palliative Care Journals

    PubMed Central

    Kumar, Senthil P

    2011-01-01

    Objective: A common disorder requiring symptom palliation in palliative and end-of-life care is cancer. Cancer pain is recognized as a global health burden. This paper sought to systematically examine the extent to which there is an adequate scientific research base on cancer pain and its reporting characteristics in the palliative care journal literature. Materials and Methods: Search conducted in MEDLINE and CINAHL sought to locate all studies published in 19 palliative/ hospice/ supportive/ end-of-life care journals from 2009 to 2010. The journals included were: American Journal of Hospice and Palliative Care, BMC Palliative Care, Current Opinion in Supportive and Palliative Care, End of Life Care Journal, European Journal of Palliative Care, Hospice Management Advisor, Indian Journal of Palliative Care, International Journal of Palliative Nursing, Internet Journal of Pain Symptom Control and Palliative Care, Journal of Pain and Palliative Care Pharmacotherapy, Journal of Palliative Care, Journal of Palliative Medicine, Journal of Social Work in End-of-life and Palliative Care, Journal of Supportive Oncology, Palliative Medicine, Palliative and Supportive Care, and Supportive Care in Cancer. Journal contents were searched to identify studies that included cancer pain in abstract. Results: During the years 2009 and 2010, of the selected 1,569 articles published in the journals reviewed, only 5.86% (92 articles) were on cancer pain. Conclusion: While researchers in the field of palliative care have studied cancer pain, the total percentage for studies is still a low 5.86%. To move the field of palliative care forward so that appropriate guidelines for cancer pain management can be developed, it is critical that more research be reported upon which to base cancer pain therapy in an evidence-based palliative care model. PMID:21633623

  14. Editorial: Journal of Comparative Psychology.

    PubMed

    Burghardt, Gordon M

    2006-05-01

    Both continuity and change typically mark the changing of editors at a long-established journal with extended editorial terms. Change is inherent in any dynamic field and is independent of editorship, but editors have an influence that should be wielded in a fair, responsible, judicious, and scientifically rigorous manner, while inevitably reflecting their own perspectives and values. The Journal of Comparative Psychology will continue to publish exciting, fascinating, assessable, controversial, and well-written reports on research, be the topic traditional, interdisciplinary, applied, or one breaking risky new ground. Editorial standards must be high, but appropriate for various subfields, and as editor the author will try to make those judgments carefully. The author would also like to see more submissions of brief reports describing exciting developments as well as submissions on significant theoretical, conceptual, and methodological issues during his tenure as editor.

  15. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway.

    PubMed

    Hirano, Wakako; Gotoh, Isamu; Uekita, Takamasa; Seiki, Motoharu

    2005-06-01

    MTCBP-1 was identified as a protein that binds the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14). Since MTCBP-1 has a putative beta-barrel structure, it is presumably a member of the recently proposed cupin superfamily that contains tremendously diverged functions of proteins in spite of their well-conserved beta-barrel structure. MTCBP-1 shows significant homology to the bacterial aci-reductone dioxygenase (ARD) in the cupin family, which is an enzyme in the methionine salvage pathway (MTA cycle). Since it is difficult to speculate the functions of cupin proteins simply based on their sequence homology, we examined whether the eukaryotic ARD homologs surely function in the methionine metabolism. Under sulfur-depleted conditions, yeast could grow when substrate of MTA cycle was provided. Disruption of the yeast ARD homolog, YMR009w gene, abolished ability of the cells to grow in this culture condition. Re-expression of either the YMR009w or MTCBP-1 gene restored the cell growth. Mutation analysis revealed that the glutamic acid residue in the beta-barrel fold and the N-terminal extension from the beta-barrel fold were found to be important for the activity to restore the growth. Thus, MTCBP-1 isolated as a binding protein for MT1-MMP was demonstrated to function as an ARD-like enzyme in the MTA cycle in yeast.

  16. Up-to-date Review and Cases Report on Chondral Defects of Knee Treated by ACI Technique: Clinical-instrumental and Histological Results.

    PubMed

    Dell'Osso, Giacomo; Ghilardi, Marco; Bottai, Vanna; Bugelli, Giulia; Guido, Giulio; Giannotti, Stefano

    2015-05-01

    The limited regenerative potential of a full thickness defect of the knee joint cartilage has certainly conditioned the development of therapeutic strategies that take into account all the aspects of the healing process. The most common treatments to repair chondral and osteochondral lesions are bone marrow stimulation, osteochondral autograft transplantation, autologous matrix-induced chondrogenesis, and autologous chondrocyte implantation. We like to emphasize the difference between a chondral and an osteochondral lesion because the difference is sometimes lost in the literature. In the context of treatment of injuries of the knee joint cartilage, the second-generation autologous chondrocyte transplant is a consolidated surgical method alternative to other techniques. Our experience with the transplantation of chondrocytes has had exceptional clinical results. We report 2 complete cases of a group of 22 in knee and ankle. These 2 cases had histological and instrumental evaluation. We cannot express conclusions, but can only make considerations, stating that, with the clinical functional result being equal, we obtained an excellent macroscopic result in both cases of second look. Autologous chondrocyte implantation (ACI) is a multiple surgical procedure with expensive chondrocyte culture, but even with this limitation, we think that it must be the choice in treating chondral lesions, especially in young patients.

  17. Aspartase/fumarase superfamily: a common catalytic strategy involving general base-catalyzed formation of a highly stabilized aci-carboxylate intermediate.

    PubMed

    Puthan Veetil, Vinod; Fibriansah, Guntur; Raj, Hans; Thunnissen, Andy-Mark W H; Poelarends, Gerrit J

    2012-05-29

    Members of the aspartase/fumarase superfamily share a common tertiary and quaternary fold, as well as a similar active site architecture; the superfamily includes aspartase, fumarase, argininosuccinate lyase, adenylosuccinate lyase, δ-crystallin, and 3-carboxy-cis,cis-muconate lactonizing enzyme (CMLE). These enzymes all process succinyl-containing substrates, leading to the formation of fumarate as the common product (except for the CMLE-catalyzed reaction, which results in the formation of a lactone). In the past few years, X-ray crystallographic analysis of several superfamily members in complex with substrate, product, or substrate analogues has provided detailed insights into their substrate binding modes and catalytic mechanisms. This structural work, combined with earlier mechanistic studies, revealed that members of the aspartase/fumarase superfamily use a common catalytic strategy, which involves general base-catalyzed formation of a stabilized aci-carboxylate (or enediolate) intermediate and the participation of a highly flexible loop, containing the signature sequence GSSxxPxKxN (named the SS loop), in substrate binding and catalysis.

  18. Comparison of Journal Citation Reports and Scopus Impact Factors for Ecology and Environmental Sciences Journals

    ERIC Educational Resources Information Center

    Gray, Edward; Hodkinson, Sarah Z.

    2008-01-01

    Impact factors for journals listed under the subject categories "ecology" and "environmental sciences" in the Journal Citation Reports database were calculated using citation data from the Scopus database. The journals were then ranked by their Scopus impact factor and compared to the ranked lists of the same journals derived from Journal…

  19. Vapor Cavitation in Dynamically Loaded Journal Bearings

    NASA Technical Reports Server (NTRS)

    Jacobson, B. O.; Hamrock, B. J.

    1983-01-01

    High speed motion camera experiments were performed on dynamically loaded journal bearings. The length to diameter ratio of the bearing, the speed of the roller and the tube, the surface material of the roller, and the static and dynamic eccentricity of the bearing were varied. One hundred and thirty-four cases were filmed. The occurrence of vapor cavitation was clearly evident in the films and figures presented. Vapor cavitation was found to occur when the tensile stress applied to the oil exceeded the tensile strength of the oil or the binding of the oil to the surface. The physical situation in which vapor cavitation occurs is during the squeezing and sliding motion within a bearing. Besides being able to accurately capture the vapor cavitation on film, an analysis of the formation and collapse of the cavitation bubbles and characteristics of the bubble content are presented.

  20. Journal of Undergraduate Research, Volume IX, 2009

    SciTech Connect

    Stiner, K. S.; Graham, S.; Khan, M.; Dilks, J.; Mayer, D.

    2009-01-01

    Each year more than 600 undergraduate students are awarded paid internships at the Department of Energy’s (DOE) National Laboratories. Th ese interns are paired with research scientists who serve as mentors in authentic research projects. All participants write a research abstract and present at a poster session and/or complete a fulllength research paper. Abstracts and selected papers from our 2007–2008 interns that represent the breadth and depth of undergraduate research performed each year at our National Laboratories are published here in the Journal of Undergraduate Research. The fields in which these students worked included: Biology; Chemistry; Computer Science; Engineering; Environmental Science; General Science; Materials Science; Medical and Health Sciences; Nuclear Science; Physics; Science Policy; and Waste Management.

  1. Effect of sampling volume on dry powder inhaler (DPI)-emitted aerosol aerodynamic particle size distributions (APSDs) measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen eight-stage cascade impactor (ACI).

    PubMed

    Mohammed, Hlack; Roberts, Daryl L; Copley, Mark; Hammond, Mark; Nichols, Steven C; Mitchell, Jolyon P

    2012-09-01

    Current pharmacopeial methods for testing dry powder inhalers (DPIs) require that 4.0 L be drawn through the inhaler to quantify aerodynamic particle size distribution of "inhaled" particles. This volume comfortably exceeds the internal dead volume of the Andersen eight-stage cascade impactor (ACI) and Next Generation pharmaceutical Impactor (NGI) as designated multistage cascade impactors. Two DPIs, the second (DPI-B) having similar resistance than the first (DPI-A) were used to evaluate ACI and NGI performance at 60 L/min following the methodology described in the European and United States Pharmacopeias. At sampling times ≥2 s (equivalent to volumes ≥2.0 L), both impactors provided consistent measures of therapeutically important fine particle mass (FPM) from both DPIs, independent of sample duration. At shorter sample times, FPM decreased substantially with the NGI, indicative of incomplete aerosol bolus transfer through the system whose dead space was 2.025 L. However, the ACI provided consistent measures of both variables across the range of sampled volumes evaluated, even when this volume was less than 50% of its internal dead space of 1.155 L. Such behavior may be indicative of maldistribution of the flow profile from the relatively narrow exit of the induction port to the uppermost stage of the impactor at start-up. An explanation of the ACI anomalous behavior from first principles requires resolution of the rapidly changing unsteady flow and pressure conditions at start up, and is the subject of ongoing research by the European Pharmaceutical Aerosol Group. Meanwhile, these experimental findings are provided to advocate a prudent approach by retaining the current pharmacopeial methodology.

  2. Frequently cited journals in forensic psychology.

    PubMed

    Black, Steve

    2012-02-01

    Works cited in six forensic psychology journals published 2008-2010 were counted to identify the most frequently cited journals. The sample of works cited (N = 21,776) was not a definitive ranked list of important journals in forensic psychology, but was large enough to indicate high-impact journals. The list of frequently cited publications included more general psychiatry and psychology journals than titles specific to forensic psychology. The implications of the proportion of general versus specific titles for collections supporting research in forensic psychology were discussed.

  3. Identifying related journals through log analysis

    PubMed Central

    Lu, Zhiyong; Xie, Natalie; Wilbur, W. John

    2009-01-01

    Motivation: With the explosion of biomedical literature and the evolution of online and open access, scientists are reading more articles from a wider variety of journals. Thus, the list of core journals relevant to their research may be less obvious and may often change over time. To help researchers quickly identify appropriate journals to read and publish in, we developed a web application for finding related journals based on the analysis of PubMed log data. Availability: http://www.ncbi.nlm.nih.gov/IRET/Journals Contact: luzh@ncbi.nlm.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. PMID:19734155

  4. Analysis of recorded biomedical book and journal use in the Yale Medical Library. I. Date and subject relations.

    PubMed

    Stangl, P; Kilgour, F G

    1967-07-01

    Analysis of book and journal circulation is based on cancelled charge slips collected over a one-year period in the Yale Medical Library. About two-fifths of material circulated were monographs. Books and journals in seven subject fields provided over half of the circulation. Approximately two-thirds of both books and journals used had been published during the most recent nine years. A subject-by-subject examination of the ratio of books to journals circulating revealed that, in subjects where proportionally more journals than books were taken out of the Library, books were of more recent imprint dates than were journals, contrary to the overall pattern. Date distribution of books and journals by subject was also studied. Results are illustrated with graphs and tables.

  5. Women's Involvement in Educational Psychology Journals from 1976 to 2004

    ERIC Educational Resources Information Center

    Evans, Joy; Hsieh, Peggy Pei-Hsuan; Robinson, Daniel H.

    2005-01-01

    Previously, Robinson, McKay, Katayama, and Fan (1998) examined women's involvement in six educational psychology journals ("American Educational Research Journal," "Contemporary Educational Psychology," "Educational Psychologist," "Educational Psychology Review," "Journal of Experimental Education," and "Journal of Educational Psychology") from…

  6. High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.

    PubMed

    Inaguma, Shingo; Takahashi, Satoru; Ohnishi, Hiroyuki; Suzuki, Shugo; Cho, Young-Man; Shirai, Tomoyuki

    2003-11-01

    Carcinogenic responses in the prostate to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were compared among seven rat strains (F344, ACI, Spontaneously Hypertensive Rat (SHR), Sprague-Dawley (SD), Wistar, Lewis and Brown Norway (BN)). Ten-week-old animals of each strain were given PhIP at 400 ppm in the diet for 20 weeks then maintained until week 54. The final survival rates were 92, 92, 83, 75, 67, 42 and 42%, respectively, and the SHR strain showed the highest sensitivity with regard to development of prostatic intraepithelial neoplasias (PINs) in the ventral prostate. With regard to the induction of adenocarcinomas of the ventral prostate, the ACI strain was most sensitive, whereas Lewis and F344 rats were relatively resistant. No adenocarcinomas were found in the dorsolateral or anterior prostate or seminal vesicles in any of the strains. The levels of serum testosterone and estrogen, PhIP-DNA adducts and cell kinetics did not correlate with the development of ventral prostatic lesions and thus other factors are presumably responsible for the variations in susceptibility. The present data indicate that ACI and SHR rats are appropriate strains for experimental investigation of PhIP-induced prostate carcinogenesis.

  7. [Journal usage at the Andrija Stampar library].

    PubMed

    Teuber, Marina; Kuri, Zdenka; Bozikov, Jadranka

    2002-09-01

    Development of journal collection in the Andrija Stampar library is presented. Research of loaned and photocopied journals was performed in order to evaluate circulation of journals in 2001. There were 1057 titles of journals in the Library, 77 were secondary journals and they were excluded from the study. 346 different titles were used 5204 times, out of which 236 were current titles. There were 11 titles used more than 100 times. Journal of Clinical Microbiology was the highest ranking journal. The greatest number of users were from the School of Public Health Andrija Stampar. Most important users of the Library were hospitals, universities, institutions, institutes of public health from Zagreb and all parts of Croatia. More recent journals were used more frequently than the old ones. Decrease of journal usage in the Library has been noticed in recent years. The reason for that are the possibilities of using full text electronic journals either through free access, or through combined subscriptions. The access to electronic journals is possible through more and more affordable subscriptions from the big publishers.

  8. Perilous terra incognita--open-access journals.

    PubMed

    Balon, Richard

    2014-04-01

    The author focuses on a new rapidly spreading practice of publication in open-access journals. The pros and cons of open-access journals are discussed. Publishing in these journals may be cost prohibitive for educators and junior faculty members. Some authors may be lured by the ease of publishing in open-access journals (and their, at times, inflated self-description, e.g., "international", "scientific"), and their possibly valuable contributions will escape the attention of Academic Psychiatry readership in the vast sea of open-access journals. The readership may be flooded with a large number of low-quality articles (maybe not even properly peer-reviewed) from open-access journals. It may take some time to sort out what is and what is not relevant and useful. Open-access publishing represents a problematic and controversial practice and may be associated with a conflict of interest for the editors and publishers of these journals.

  9. A systematic appraisal of the Evidence-Based Dentistry Journal.

    PubMed

    Mehta, Nikisha; Marshman, Zoe

    2016-09-01

    BackgroundThis systematic appraisal was conducted to determine if the Evidence-Based Dentistry Journal (EBDJ) acts as a reliable and contemporary source of knowledge for practitioners across all disciplines within dentistry.ObjectivesThe main objectives were to determine i) the year the articles were published and included in the EBDJ; ii) if the articles published covered all fields equally within dentistry; iii) the type of study design of the articles reported in the journal and; iv) the level of expertise of the writers of the commentaries.MethodsThis study used a systematic approach to assess the articles included in the journal. Data were extracted on the difference in the year the article was originally published and the year the article was included in the EBDJ, the number of articles in each dental discipline, the type of study designs included in the journal and the expertise of the commentators of each article. The information provided by the journal was validated by accessing the original articles through electronic databases.ResultsThe appraisal considered the 582 articles that met the inclusion criteria. Overall, 45.3% of the articles were included in the EBDJ in the same year and 44.8% of the articles were included a year after they were originally published. The number of articles varied across disciplines within dentistry: 23.7% from dental public health, 18.4% from periodontology and 11.8% from orthodontics, with only 4.6% from prosthodontics, 1% from oral pathology and 0.5% from dental materials. Most of the articles were systematic reviews and randomised controlled trials at 72% and 22.3% respectively. The writers of the commentaries were mostly academics and hospital consultants (71.2% and 13.6% commentators).ConclusionsOn the whole, it can be concluded that the journal acts as a reliable and contemporary source of knowledge/evidence for dentists, however, not all specialities within dentistry had equal coverage.

  10. Legal regulation of the Croatian Medical Journal: model for small academic journals.

    PubMed

    Marusic, Matko; Bosnjak, Darko; Rulic-Hren, Silva; Marusic, Ana

    2003-12-01

    During the last few years, the questions of editorial independence and journal governance have come into the focus of scholarly journals. There is little data on the legal regulation of journals outside mainstream science, although they constitute the largest body of biomedical literature. The Croatian Medical Journal functioned for more than 10 years without much legal regulation but with lot of enthusiasm and hard work. This Editorial presents our attempt to make legal provisions for the current status of the Journal and its future work. We defined our owners, main participants in making of the journal, and their responsibilities and benefits. The Agreement will be signed by all four medical schools in Croatia, which will become owners of the Journal. We hope that our experiences and solutions for strengthening the legal status of the Journal will help other editors from small scientific communities to think about their journal and its governance.

  11. Citation patterns in tropical medicine journals.

    PubMed

    Schoonbaert, Dirk

    2004-11-01

    Selections of most important journals in the field of tropical medicine have previously been identified with the help of resources such as bibliographical and citation databases. This article uses ISI's Journal Citation Reports (JSR) for 2002 to analyse the citation characteristics of the Tropical Medicine category. According to these data, this small but diverse group of 12 journals bestows some 40% more citations than it receives. Its six typical core journals tend to cite one another heavily, but they also refer a lot to multidisciplinary science and general medicine journals, and to infectious diseases and parasitology journals. Looking at the sources from which JCR's tropical medicine journals derive their citations, it is clear that in this reverse direction, the specialty's literature is still more concentrated. Apart from the typical core, this JCR category also contains a number of journals with more idiosyncratic citing patterns, focused on specialties such as paediatrics, a single disease (leprosy) and a representative of Latin American and Francophone biomedical science each. Implications of concentrated citedness and language biases are discussed briefly. This paper features a selection of bibliometric parameters relating to the tropical medicine journals and lists of the 80 journals most citing and cited by them.

  12. Trends in impact factors of ophthalmology journals

    PubMed Central

    Vainer, Igor; Mimouni, Francis; Blumenthal, Eytan Z; Mimouni, Michael

    2016-01-01

    Purpose: To test whether there is an association between the growth in the number of ophthalmic journals in the past years and their mean and maximum impact factor (IF) as a common sign of scientific proliferation. Methods: Using data from the 2013 Journal Citation Report database a study of the major clinical medical fields was conducted to assess the correlation between the number of journals and maximum IF in a given field in the year 2013. In the field of ophthalmology, we examined the correlation between year, number of journals, mean IF and maximum IF in the field of ophthalmology throughout the years 2000–2013. Results: In the major medical fields, a positive correlation was found between the number of journals and the maximum IF (quadratic R2 = 0.71, P < 0.001). When studying the field of ophthalmology a positive correlation between the number of journals and mean IF (R2 = 0.84, P < 0.001) and between number of journals and maximum IF (R2 = 0.71, P < 0.001) was detected. Conclusions: Our findings suggest that the variation in the IF can be explained by the number of journals in the field of ophthalmology. In the future, the formation of additional ophthalmology journals is likely to further increase the IFs of existing journals. PMID:27853016

  13. Chandra ACIS Survey of X-Ray Point Sources in Nearby Galaxies. II. X-Ray Luminosity Functions and Ultraluminous X-Ray Sources

    NASA Astrophysics Data System (ADS)

    Wang, Song; Qiu, Yanli; Liu, Jifeng; Bregman, Joel N.

    2016-09-01

    Based on the recently completed Chandra/ACIS survey of X-ray point sources in nearby galaxies, we study the X-ray luminosity functions (XLFs) for X-ray point sources in different types of galaxies and the statistical properties of ultraluminous X-ray sources (ULXs). Uniform procedures are developed to compute the detection threshold, to estimate the foreground/background contamination, and to calculate the XLFs for individual galaxies and groups of galaxies, resulting in an XLF library of 343 galaxies of different types. With the large number of surveyed galaxies, we have studied the XLFs and ULX properties across different host galaxy types, and confirm with good statistics that the XLF slope flattens from lenticular (α ˜ 1.50 ± 0.07) to elliptical (˜1.21 ± 0.02), to spirals (˜0.80 ± 0.02), to peculiars (˜0.55 ± 0.30), and to irregulars (˜0.26 ± 0.10). The XLF break dividing the neutron star and black hole binaries is also confirmed, albeit at quite different break luminosities for different types of galaxies. A radial dependency is found for ellipticals, with a flatter XLF slope for sources located between D 25 and 2D 25, suggesting the XLF slopes in the outer region of early-type galaxies are dominated by low-mass X-ray binaries in globular clusters. This study shows that the ULX rate in early-type galaxies is 0.24 ± 0.05 ULXs per surveyed galaxy, on a 5σ confidence level. The XLF for ULXs in late-type galaxies extends smoothly until it drops abruptly around 4 × 1040 erg s-1, and this break may suggest a mild boundary between the stellar black hole population possibly including 30 M ⊙ black holes with super-Eddington radiation and intermediate mass black holes.

  14. Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation.

    PubMed

    Zhang, Yuan; Wang, Ting; Yang, Ke; Xu, Ji; Ren, Lijie; Li, Weiping; Liu, Wenlan

    2016-01-01

    Enolase-phosphatase 1 (ENOPH1), a newly discovered enzyme of the methionine salvage pathway, is emerging as an important molecule regulating stress responses. In this study, we investigated the role of ENOPH1 in blood brain barrier (BBB) injury under ischemic conditions. Focal cerebral ischemia induced ENOPH1 mRNA and protein expression in ischemic hemispheric microvessels in rats. Exposure of cultured brain microvascular endothelial cells (bEND3 cells) to oxygen-glucose deprivation (OGD) also induced ENOPH1 upregulation, which was accompanied by increased cell death and apoptosis reflected by increased 3-(4, 5-Dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide formation, lactate dehydrogenase release and TUNEL staining. Knockdown of ENOPH1 expression with siRNA or overexpressing ENOPH1 with CRISPR-activated plasmids attenuated or potentiated OGD-induced endothelial cell death, respectively. Moreover, ENOPH1 knockdown or overexpression resulted in a significant reduction or augmentation of reactive oxygen species (ROS) generation, apoptosis-associated proteins (caspase-3, PARP, Bcl-2 and Bax) and Endoplasmic reticulum (ER) stress proteins (Ire-1, Calnexin, GRP78 and PERK) in OGD-treated endothelial cells. OGD upregulated the expression of ENOPH1's downstream protein aci-reductone dioxygenase 1 (ADI1) and enhanced its interaction with ENOPH1. Interestingly, knockdown of ENOPH1 had no effect on OGD-induced ADI1 upregulation, while it potentiated OGD-induced ADI1 translocation from the nucleus to the cytoplasm. Lastly, knockdown of ENOPH1 significantly reduced OGD-induced endothelial monolayer permeability increase. In conclusion, our data demonstrate that ENOPH1 activation may contribute to OGD-induced endothelial cell death and BBB disruption through promoting ROS generation and the activation of apoptosis associated proteins, thus representing a new therapeutic target for ischemic stroke.

  15. Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation

    PubMed Central

    Zhang, Yuan; Wang, Ting; Yang, Ke; Xu, Ji; Ren, Lijie; Li, Weiping; Liu, Wenlan

    2016-01-01

    Enolase-phosphatase 1 (ENOPH1), a newly discovered enzyme of the methionine salvage pathway, is emerging as an important molecule regulating stress responses. In this study, we investigated the role of ENOPH1 in blood brain barrier (BBB) injury under ischemic conditions. Focal cerebral ischemia induced ENOPH1 mRNA and protein expression in ischemic hemispheric microvessels in rats. Exposure of cultured brain microvascular endothelial cells (bEND3 cells) to oxygen-glucose deprivation (OGD) also induced ENOPH1 upregulation, which was accompanied by increased cell death and apoptosis reflected by increased 3-(4, 5-Dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide formation, lactate dehydrogenase release and TUNEL staining. Knockdown of ENOPH1 expression with siRNA or overexpressing ENOPH1 with CRISPR-activated plasmids attenuated or potentiated OGD-induced endothelial cell death, respectively. Moreover, ENOPH1 knockdown or overexpression resulted in a significant reduction or augmentation of reactive oxygen species (ROS) generation, apoptosis-associated proteins (caspase-3, PARP, Bcl-2 and Bax) and Endoplasmic reticulum (ER) stress proteins (Ire-1, Calnexin, GRP78 and PERK) in OGD-treated endothelial cells. OGD upregulated the expression of ENOPH1’s downstream protein aci-reductone dioxygenase 1 (ADI1) and enhanced its interaction with ENOPH1. Interestingly, knockdown of ENOPH1 had no effect on OGD-induced ADI1 upregulation, while it potentiated OGD-induced ADI1 translocation from the nucleus to the cytoplasm. Lastly, knockdown of ENOPH1 significantly reduced OGD-induced endothelial monolayer permeability increase. In conclusion, our data demonstrate that ENOPH1 activation may contribute to OGD-induced endothelial cell death and BBB disruption through promoting ROS generation and the activation of apoptosis associated proteins, thus representing a new therapeutic target for ischemic stroke. PMID:27630541

  16. Regulated nucleo-cytoplasmic shuttling of human aci-reductone dioxygenase (hADI1) and its potential role in mRNA processing.

    PubMed

    Gotoh, Isamu; Uekita, Takamasa; Seiki, Motoharu

    2007-01-01

    Bacterial aci-reductone dioxygenase (ARD), a member of the cupin superfamily, has evolutionarily primitive protein folding and functions in the methionine recycling pathway. Recently, a human ARD orthologue (human ADI1, hADI1) has been identified and exhibits functions other than ARD activity. The hADI1 localizes mainly to the cytoplasm, but a substantial fraction is nuclear, suggesting functions in both cellular compartments. In this study, we report that nucleo-cytoplasmic transport of hADI1 is regulated by a non-canonical nuclear export signal (NES) located in the N-terminal region of hADI1. The NES is composed of multiple basic amino-acid residues instead of the canonical leucine-rich sequence. Nuclear export of hADI1 was not mediated by CRM1, a major transporter that binds to leucine-rich NES. Substitution of the basic residues with alanines abolished NES activity. Mutant hADI1 accumulated in the nucleus and formed speckles frequently observed with splicing factors and some transcription factors. Indeed, hADI1 specifically co-localized with the splicing factor U1-70K to the nucleus but not with another splicing factor, SC35. U1-70K over-expression induced nuclear accumulation of hADI1. Nuclear hADI1 expression significantly altered the splicing pattern of the adenovirus E1A mini-gene, which generates multiple alternatively spliced transcripts. Thus, hADI1 may have acquired a novel role in nuclear mRNA processing possibly by modulating U1-70K-related functions, an activity negatively regulated by a non-classical NES sequence.

  17. In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells.

    PubMed

    Dasmahapatra, Girija; Patel, Hiral; Friedberg, Johnathan; Quayle, Steven N; Jones, Simon S; Grant, Steven

    2014-12-01

    Interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib were examined in non-Hodgkin lymphoma (NHL) models, including diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and double-hit lymphoma cells. Marked in vitro synergism was observed in multiple cell types associated with activation of cellular stress pathways (e.g., JNK1/2, ERK1/2, and p38) accompanied by increases in DNA damage (γH2A.X), G2-M arrest, and the pronounced induction of mitochondrial injury and apoptosis. Combination treatment with carfilzomib and ricolinostat increased reactive oxygen species (ROS), whereas the antioxidant TBAP attenuated DNA damage, JNK activation, and cell death. Similar interactions occurred in bortezomib-resistant and double-hit DLBCL, MCL, and primary DLBCL cells, but not in normal CD34(+) cells. However, ricolinostat did not potentiate inhibition of chymotryptic activity by carfilzomib. shRNA knockdown of JNK1 (but not MEK1/2), or pharmacologic inhibition of p38, significantly reduced carfilzomib-ricolinostat lethality, indicating a functional contribution of these stress pathways to apoptosis. Combined exposure to carfilzomib and ricolinostat also markedly downregulated the cargo-loading protein HR23B. Moreover, HR23B knockdown significantly increased carfilzomib- and ricolinostat-mediated lethality, suggesting a role for this event in cell death. Finally, combined in vivo treatment with carfilzomib and ricolinostat was well tolerated and significantly suppressed tumor growth and increased survival in an MCL xenograft model. Collectively, these findings indicate that carfilzomib and ricolinostat interact synergistically in NHL cells through multiple stress-related mechanisms, and suggest that this strategy warrants further consideration in NHL.

  18. Biosources digest, journal on biomass utilization, volume 2, number 4

    NASA Astrophysics Data System (ADS)

    Sobel, H.

    1980-10-01

    The journal serves as an information exchange in biomass utilization for food, energy, chemicals, and materials. The following papers are presented in this issue: Energy and Forestry in Canada; Comparative Activity Profiles of Thielavia Terrestris and Trichoderma reesei Cellulases; Biogas: The Chinese Experience; Introduction to the Botany 1980 Symposium: Plants and Energy; and Biomass for Energy: Potentials in Arizona. Grant awards, publications received, recent publications, pertinent patents, and forth coming meetings are noted.

  19. Do Croatian open access journals support ethical research? Content analysis of instructions to authors

    PubMed Central

    Stojanovski, Jadranka

    2015-01-01

    Introduction The aim of our study was to investigate the extent to which Instructions to authors of the Croatian open access (OA) journals are addressing ethical issues. Do biomedical journals differ from the journals from other disciplines in that respect? Our hypothesis was that biomedical journals maintain much higher publication ethics standards. Materials and methods This study looked at 197 Croatian OA journals Instructions to authors to address the following groups of ethical issues: general terms; guidelines and recommendations; research approval and registration; funding and conflict of interest; peer review; redundant publications, misconduct and retraction; copyright; timeliness; authorship; and data accessibility. We further compared a subset of 159 non-biomedical journals with a subset of 38 biomedical journals. Content analysis was used to discern the ethical issues representation in the instructions to authors. Results The groups of biomedical and non-biomedical journals were similar in terms of originality (χ2 = 2.183, P = 0.140), peer review process (χ2 = 0.296, P = 0.586), patent/grant statement (χ2 = 2.184, P = 0.141), and timeliness of publication (χ2 = 0.369, P = 0.544). We identified significant differences among categories including ethical issues typical for the field of biomedicine, like patients (χ2 = 47.111, P < 0.001), and use of experimental animals (χ2 = 42.543, P < 0.001). Biomedical journals also rely on international editorial guidelines formulated by relevant professional organizations heavily, compared with non-biomedical journals (χ2 = 42.666, P < 0.001). Conclusion Low representation or absence of some key ethical issues in author guidelines calls for more attention to the structure and the content of Instructions to authors in Croatian OA journals. PMID:25672463

  20. Losses of Superconductor Journal Bearing

    NASA Astrophysics Data System (ADS)

    Han, Y. H.; Hull, J. R.; Han, S. C.; Jeong, N. H.; Oh, J. M.; Sung, T. H.

    2004-06-01

    A high-temperature superconductor (HTS) journal bearing was studied for rotational loss. Two HTS bearings support the rotor at top and bottom. The rotor weight is 4 kg and the length is about 300 mm. Both the top and bottom bearings have two permanent magnet (PM) rings with an iron pole piece separating them. Each HTS journal bearing is composed of six pieces of superconductor blocks of size 35×25×10 mm. The HTS blocks are encased in a cryochamber through which liquid nitrogen flows. The inner spool of the cryochamber is made from G-10 to reduce eddy current loss, and the rest of the cryochamber is stainless steel. The magnetic field from the PM rings is < 10 mT on the stainless part. The rotational drag was measured over the same speed range at several chamber pressures. Results indicate that a chamber pressure of 0.4 mtorr is sufficiently low to minimize windage loss, and the 10 mT design criterion for the magnetic field on the stainless part of the cryochamber is too high.

  1. A history of the Journal of Parasitology.

    PubMed

    Esch, Gerald; Desser, Sherwin; Nickol, Brent

    2014-02-01

    The present issue is Number 1 of Volume 100, The Journal of Parasitology. All 6 numbers of this, our Centennial Volume, are dedicated to those in the past who have contributed in any manner to the Journal's success as a national and international broker for parasitology. Our essay on the history of the Journal is divided into 3 parts. The first extends from 1914 to 1932, i.e., 'the beginning', when Henry Baldwin Ward was Editor and owned the Journal. The 'middle years' continue from 1933, when Ward gave the Journal to the American Society of Parasitologists, to 1961. The 'current period' carries on from 1961 to the present, our Centennial year. Obviously, we cannot provide a great many specific details for each era, but we have made an effort to identify some of the events, issues, and people that have played a significant role in our Journal's history.

  2. Numerical investigation of cavitation flow in journal bearing geometry

    NASA Astrophysics Data System (ADS)

    Riedel, M.; Schmidt, M.; Stücke, P.

    2013-04-01

    The appearance of cavitation is still a problem in technical and industrial applications. Especially in automotive internal combustion engines, hydrodynamic journal bearings are used due to their favourable wearing quality and operating characteristics. Cavitation flows inside the bearings reduces the load capacity and leads to a risk of material damages. Therefore an understanding of the complex flow phenomena inside the bearing is necessary for the design development of hydrodynamic journal bearings. Experimental investigations in the fluid domain of the journal bearing are difficult to realize founded by the small dimensions of the bearing. In the recent years more and more the advantages of the computational fluid dynamics (CFD) are used to investigate the detail of the cavitation flows. The analysis in the paper is carried out in a two-step approach. At first an experimental investigation of journal bearing including cavitation is selected from the literature. The complex numerical model validated with the experimental measured data. In a second step, typically design parameters, such as a groove and feed hole, which are necessary to distribute the oil supply across the gap were added into the model. The paper reflects on the influence of the used design parameters and the variation of the additional supply flow rate through the feed hole regarding to cavitation effects in the bearing. Detailed pictures of the three-dimensional flow structures and the cavitation regions inside the flow film of the bearing are presented.

  3. PUBLISHER'S ANNOUNCEMENT: A revised scope for Journal of Micromechanics and Microengineering A revised scope for Journal of Micromechanics and Microengineering

    NASA Astrophysics Data System (ADS)

    Forbes, Ian

    2010-05-01

    Journal of Micromechanics and Microengineering is well known for publishing excellent work in highly competitive timescales. The journal's coverage has consistently evolved to reflect the current state of the field, and from May 2010 it will revisit its scope once again. The aims of the journal remain unchanged, however: to be the first choice of authors and readers in MEMS and micro-scale research. The new scope continues to focus on highlighting the link between fabrication technologies and their capacity to create novel devices. This link will be considered paramount in the journal, and both prospective authors and readers should let it serve as an inspiration to them. The burgeoning fields of NEMS and nano-scale engineering are more explicitly supported in the new scope. Research which ten years ago would have been considered science fiction has, through the tireless efforts of the community, become reality. The Editorial Board feel it is important to reflect the growing significance of this work in the scope. The new scope, drafted by Editor-in-Chief Professor Mark Allen, and approved by the Editorial Board, is as follows: Journal of Micromechanics and Microengineering covers all aspects of microelectromechanical structures, devices, and systems, as well as micromechanics and micromechatronics. The journal focuses on original work in fabrication and integration technologies, on the micro- and nano-scale. The journal aims to highlight the link between new fabrication technologies and their capacity to create novel devices. Original work in microengineering and nanoengineering is also reported. Such work is defined as applications of these fabrication and integration technologies to structures in which key attributes of the devices or systems depend on specific micro- or nano-scale features. Such applications span the physical, chemical, electrical and biological realms. New fabrication and integration techniques for both silicon and non-silicon materials are

  4. Journal of Neurodevelopmental Disorders reviewer acknowledgement 2012

    PubMed Central

    2013-01-01

    Contributing reviewers The editors of Journal of Neurodevelopmental Disorders would like to thank all of our reviewers who have contributed to the journal in volume 4 (2012). High quality and timely reviews are critical to the overall quality of the journal. We are committed to providing a unique and important outlet for scholarship regarding neurodevelopmental disorders and are indebted to the outstanding reviewers who have contributed their time over the last year in helping us to reach this goal. PMID:23517765

  5. [The Journals role in continuing medical education].

    PubMed

    Ramiro-H, Manuel; Cruz-A, J Enrique

    2017-01-01

    In the 19th century, the first journals in medicine appeared in order to disseminate knowledge among creators and discoverers, but especially among users of knowledge, some of these journals continue to be published nowadays. Subsequently, an organization that initially aspired to collect, sort, archive and distribute the publications: the Index Medicus. Over time, it was imperative to create indexes that measure the performance of journals and with that of researchers.

  6. Community health orientation of Indian Journal of Endocrinology and Metabolism: A bibliometric analysis of Indian Journal of Endocrinology and Metabolism

    PubMed Central

    Kaushal, Kanica; Kalra, Sanjay

    2015-01-01

    Background: Endocrine and metabolic diseases especially diabetes have become focus areas for public health professionals. Indian Journal of Endocrinology and Metabolism (IJEM), a publication of Endocrine Society of India, is a peer-reviewed online journal, which covers technical and clinical studies related to health, ethical and social issues in field of diabetes, endocrinology and metabolism. This bibliometric analysis assesses the journal from a community health perspective. Materials and Methods: Every article published in IJEM over a period of 4 years (2011–2014) was accessed to review coverage of community health in the field of endocrinology. Results: Seven editorials, 30 review articles, 41 original articles, 12 brief communications, 20 letter to editors, 4 articles on guidelines and 2 in the section “endocrinology and gender” directly or indirectly dealt with community health aspects of endocrinology. Together these amounted to 17% of all articles published through these 4 years. There were 14 articles on general, 60 pertaining to pancreas and diabetes, 10 on thyroid, 7 on pituitary/adrenal/gonads, 21 on obesity and metabolism and 4 on parathyroid and bone; all community medicine related. Conclusion: Community health is an integral part of the modern endocrinology diabetology and metabolism practice and it received adequate journal space during the last 4 years. The coverage is broad based involving all the major endocrine disorders. PMID:25932398

  7. EDITORIAL: Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter Richard Palmer: celebrating 37 years with Journal of Physics: Condensed Matter

    NASA Astrophysics Data System (ADS)

    Ferry, David

    2009-01-01

    in Materials Science and Engineering. Under the new structure, journal development became an increasingly important part of his job. At about the same time, Richard was also asked to take over running Reports on Progress in Physics, which up to then had been done by the head of the IOP Journals Department, Kurt Paulus. In 1989, Journal of Physics C: Solid State Physics and Journal of Physics F: Metal Physics remerged to form JPCM. Since then, Richard has gradually shed his other journal responsibilities, except for Reports on Progress in Physics, to build up JPCM. He has worked closely with four Editors-in-Chief of Journal of Physics C: Solid State Physics, five of JPCM, five of Reports on Progress in Physics and about ten of other journals, and attended approximately 300 Editorial Board meetings. I should say that he has made my own tenure at Editor-in-Chief an easy task to learn and take on, and has been a major guiding light in the development of the journal. In 2006, Richard was honoured by the award of a Member of the British Empire (MBE) for services to science publishing. Those of us on the board were particularly pleased about this, as one is not always recognized for the effort they expend, and this award was certainly due for Richard. We are going to miss Richard a great deal, but are happy that he will remain on a part time basis to help our new Publisher, Dr Lucy Smith, and the rest of us through the transition. His retirement leaves us with a huge hole that we will have to work extremely hard to fill. Speaking for the various boards, and especially the executive board, I want to wish Richard the very best in his retirement.

  8. Structural Integrity of Intelligent Materials and Structures

    DTIC Science & Technology

    1998-03-01

    Laminates," International Journal for Numerical Methods and Engineering (in press). 3. "Coupled Thermomechanical Simulation of Shape Memory Alloys...interpolation polynomials," AIAA Journal , 30, No 11, Nov. 1992. 5. Chang, Fu-Kuo, Perez, J.L., and Chang, K.Y., "Analysis of thick laminated composites...34 Journals of Composite Materials, 24, 801-822, August 1990. 6. Christensen, R.M., Mechanics of Composite Materials, John Wiley & Sons, NY 1979. 7

  9. Reflective Journaling as a Flipped Classroom Technique to Increase Reading and Participation With Social Work Students

    PubMed Central

    Sage, Melanie; Sele, Patti

    2016-01-01

    Students in undergraduate social work practice courses come to the class with varying levels of educational, life, and practice experience. Students require an introduction to the material through textbook reading before they are able to engage in critical discussions, yet reading adherence varies widely among students. This research explores the use of reflective journals as a Flipped Classroom technique to increase reflective thinking and reading adherence. This study surveys 27 students in two practice courses about the use of weekly reflective journaling as a flipped classroom assignment. Findings support that reflective reading journals increase student preparation and engagement, but require more work for students and instructors. Implications are discussed. PMID:27672301

  10. Scholastic Journalism Week, February 23-29, 1992. Celebrating 200 Years, Freedom of the Press, Bill of Rights.

    ERIC Educational Resources Information Center

    Journalism Education Association.

    Designed to raise community consciousness regarding the benefits of scholastic journalism, this collection of material offers suggestions for celebrating Scholastic Journalism Week. The collection provides: brief suggestions for 11 school activities; brief descriptions of 8 classroom activities; a sample press release for scholastic journalism…

  11. What Happens at the Journal Office Stays at the Journal Office: Assessing Journal Transparency and Record-Keeping Practices

    ERIC Educational Resources Information Center

    Yoder, Stephen; Bramlett, Brittany H.

    2011-01-01

    Dissemination of journal submission data is critical for identifying editorial bias, creating an informed scholarly marketplace, and critically mapping the contours of a discipline's scholarship. However, our survey and case study investigations indicate that nearly a decade after the Perestroika movement began, political science journals remain…

  12. Ethical dilemmas in journal publication.

    PubMed

    Babalola, Olubukola; Grant-Kels, Jane M; Parish, Lawrence Charles

    2012-01-01

    Physicians often face tremendous pressures and incentives to publish, sometimes leading to a compromise of ethical standards, either consciously or unconsciously. From the vantage of ethical authorship, we discuss what constitutes authorship; avoidance of ghost authorship; plagiarism, as well as self-plagiarism and duplicate publication; falsification; and fabrication. Editors also face ethical challenges, including how best to manage peer-review bias, to address reviewer tardiness, and to locate reviewers with appropriate expertise and professionalism. Editors need to deal with authors who fragment their work into multiple publications to enhance their curriculum vitae ("salami factor"), as well as to manage the financial benefits of advertising and to avoid conflicts of interest for the journal. Both authors and editors should be straightforward and principled throughout the publication process.

  13. [Scientific journalism and epidemiological risk].

    PubMed

    Luiz, Olinda do Carmo

    2007-01-01

    The importance of the communications media in the construction of symbols has been widely acknowledged. Many of the articles on health published in the daily newspapers mention medical studies, sourced from scientific publications focusing on new risks. The disclosure of risk studies in the mass media is also a topic for editorials and articles in scientific journals, focusing the problem of distortions and the appearance of contradictory news items. The purpose of this paper is to explore the meaning and content of disclosing scientific risk studies in large-circulation daily newspapers, analyzing news items published in Brazil and the scientific publications used as their sources during 2000. The "risk" is presented in the scientific research projects as a "black box" in the meaning of Latour, with the news items downplaying scientific disputes and underscoring associations between behavioral habits and the occurrence of diseases, emphasizing individual aspects of the epidemiological approach, to the detriment of the group.

  14. Redesigning journal club in residency

    PubMed Central

    Al Achkar, Morhaf

    2016-01-01

    The gap between production and implementation of knowledge is the main reason for the suboptimal quality of health care. To eliminate this gap and improve the quality of patient care, journal club (JC) in graduate medical education provides an opportunity for learning the skills of evidence-based medicine. JC, however, continues to face many challenges mainly due to poorly defined goals, inadequate preparation, and lack of interest. This article presents an innovative model to prepare and present JC based on three pillars: dialogical learning through group discussion, mentored residents as peer teachers, and including JC as part of a structured curriculum to learn evidence-based medicine. This engaging model has the potential to transform JC from a moribund session that is daunting for residents into a lively discussion to redefine clinical practice using the most current evidence. PMID:27313486

  15. [Medical journals and open access].

    PubMed

    Sember, Marijan

    2008-01-01

    The open access (OA) or the idea of a free access to scholarly literature published in electronic form has been already well established in the field of medicine. Medline has already been free for a decade, PubMed Central has been growing steadily. The global crisis of the scientific publishing, becoming increasingly dominated by multinational companies and constant increase of journal prices have moved to action not only individuals and institutions but governments and research charities too. The aim of this article is to give an overview of the main open access initiatives and resources in biomedicine (PubMed, PubMed Central, BioMed Central, PLoS). The OA pros and cons are briefly discussed emphasizing the benefits of OA to medical research and practice.

  16. The International Journal of Astrobiology

    NASA Astrophysics Data System (ADS)

    Wynn-Williams, David D.

    2002-01-01

    The launch of a new journal is appropriately like a space mission. It is the result of a scientific need, the inspiration of a group of committed scientists and technologists, a series of draft proposals, an approved mission protocol, and a launch. Today is the launch day for a journal whose remit has only recently consolidated from diverse disciplines. Cambridge University Press has an international reputation for astronomy. To this we add extreme biology and its associated environmental research to integrate astrobiology as: 'the study of the origin, evolution, adaptation and distribution of past and present life in the Universe'. Astrobiology has three main themes: (1) Origin, evolution and limits of life on Earth; (2) Future of life, both on Earth and elsewhere; (3) Search for habitats, biomolecules and life in the Solar System and elsewhere. These fundamental concepts require the integration of various disciplines, including biology (especially microbiology), chemistry, geology, palaeontology, and the physics of atmospheres, planets and stars. We must also keep our minds wide open about the nature and limits of life. We can safely assume a carbon-based system within Solar Systems as we know them, but our concept of habitable zones expands yearly. We were taught that only the spores of certain bacilli could survive temperatures above the boiling point of water, and yet we now know that the deep-sea vent microbe Pyrolobus can survive an hour at 121 °C, which is the temperature used for sterilising medical instruments. We know of cyanobacteria which can not only live inside deep-frozen Antarctic rocks but also survive on roof-tops in Jerusalem at 80 °C. The bacterium Deinococcus radiodurans tolerates lethal doses of nuclear radiation, and cyanobacteria inside Antarctic desert sandstone receive so little moisture that their carbon turnover time (from its fixation by photosynthesis to its release as carbon dioxide during respiration) is 10,000 years. Life is

  17. A Modest Proposal: One Way to Save Journalism and Journalism Education

    ERIC Educational Resources Information Center

    John, Jeffrey Alan

    2013-01-01

    This essay suggests that because anyone and everyone can now be a "journalist," the standards of the field of journalism have been greatly diminished. To regain respect for the profession and retain stature in the academy, journalism education should offer an assurance of the legitimacy of journalism program graduates by recognizing only…

  18. [The Orvosi Hetilap (Hungarian Medical Journal) in the network of medical journals].

    PubMed

    Schubert, András

    2014-06-01

    The role of networks is swiftly increasing in the production and communication of scientific knowledge. Network aspects have, therefore, an ever growing importance in the analysis of the scientific enterprise, as well. The present paper demonstrates some techniques of studying the network of scientific journals on the subject of seeking the position of Orvosi Hetilap (Hungarian Medical Journal) in the international journal network.

  19. A journal-level analysis of Health Communication.

    PubMed

    Feeley, Thomas Hugh; Smith, Rachel A; Moon, Shin-Il; Anker, Ashley E

    2010-09-01

    Citation data from 2006 through 2008 were used to examine the journal citation network of Health Communication in comparison to 26 related journals indexed by Journal Citation Reports, a database published by the Institute for Scientific Information (ISI) Web of Knowledge. A recently advanced journal relatedness factor based on out-degree (i.e., cited journals) and in-degree (i.e., citing journals) citations was used to determine the network of peer journals. Results indicate Health Communication serves to link communication and health-related journals. Data were also reported on journal impact and 5-year journal impact factors. When compared to ISI-indexed communication journals, Health Communication is consistently ranked in the top 25% across impact factors and citations to the journal are consistent over the 7 years of analysis from 2002 through 2008. Methods of increasing the impact of Health Communication among journals in social sciences are discussed.

  20. Predatory Journals, Peer Review, and Education Research

    ERIC Educational Resources Information Center

    Beall, Jeffrey

    2017-01-01

    This commentary examines the problem of predatory journals, low-quality open-access journals that seek to earn revenue from scholarly authors without following scholarly publishing best practices. Seeking to accept as many papers as possible, they typically do not perform a standard peer review, leading to the publication of improperly vetted…

  1. Academic Journal Embargoes and Full Text Databases.

    ERIC Educational Resources Information Center

    Brooks, Sam

    2003-01-01

    Documents the reasons for embargoes of academic journals in full text databases (i.e., publisher-imposed delays on the availability of full text content) and provides insight regarding common misconceptions. Tables present data on selected journals covering a cross-section of subjects and publishers and comparing two full text business databases.…

  2. The Journal of Educational Relations, 1995.

    ERIC Educational Resources Information Center

    Holliday, Albert E., Ed.

    1995-01-01

    This document consists of the four issues of the "Journal of Educational Relations" published during 1995. The Journal's motto is "Promoting Student Achievement through Positive School-Home-Community Relationships." Articles in the first issue include: "Disarming Information: Ways to Counter Negative Critics" (Gerald Bracey); "Most Superintendents…

  3. Mentoring Academic Journal Reviewers: Brokering Reviewing Knowledge

    ERIC Educational Resources Information Center

    Adamson, John

    2012-01-01

    This paper reports on an ongoing programme to develop new academic journal reviewers through mentoring. It analyses data from correspondence between experienced reviewer/mentors and new reviewer/mentees at an online journal. With the overlying objective of improving internal review quality, the mentoring programme has been initiated to raise…

  4. The Student, Journal Writing, and Assessment.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Journal writing gives students opportunities to practice writing in a way relevant to their experiences and not merely as an exercise in writing for writing's sake. There are many opportunities for a student to write about subject matter learned from ongoing lessons, as examples from the journal of a sixth grader illustrate. Listening to current…

  5. Referencing web pages and e-journals.

    PubMed

    Bryson, David

    2013-12-01

    One of the areas that can confuse students and authors alike is how to reference web pages and electronic journals (e-journals). The aim of this professional development article is to go back to first principles for referencing and see how with examples these should be referenced.

  6. Canadian Journal of Native Studies: An Assessment.

    ERIC Educational Resources Information Center

    Price, Richard T.

    1987-01-01

    Describes and critically analyzes volume of "Canadian Journal of Native Studies" (v4 n2 1984). Sketches journal's history and critiques three articles. Article topics include history (Indian treaties and Indian policy administration); resource development impacts (reserve land flooding, native health, and fishing); and native education…

  7. Australian Education Journals: Quantitative and Qualitative Indicators

    ERIC Educational Resources Information Center

    Haddow, Gaby; Genoni, Paul

    2009-01-01

    This paper reports on a study that applied citation-based measurements to Australian education journals. Citations data were drawn from two sources, Web of Science and Scopus, and these data were used to calculate each journal's impact factor, "h"-index, and diffusion factor. The rankings resulting from these analyses were compared with…

  8. Airpower Journal Index 1987-1991

    DTIC Science & Technology

    1993-02-01

    AD-A20613 551 A1DFW’A~D. TIG JOURNAL.~’~:1191 Approved for public releuj Ift Airpower Journal Index 1987-1991 LT COL MICHAHl A. KIRTLAND 93-08836 Air...vii P reface . .. . ... ......... .. ... .... . .. . ... .. . ... .. ix A uthor Index .................................... I Articles and...Editorials ....................... 3 Title Index .................................... 15 Articles and Editorials ........ ................... 17 Subject

  9. Comprehensive Planning in a Journalism Department.

    ERIC Educational Resources Information Center

    Rogers, James L.

    The experience of the North Texas State University journalism department in undertaking a process for planning and budgeting is described. General observations on university planning and budgeting are followed by the considerations that are relevant in planning for journalism education. University and department level planning for the 1980-84…

  10. English Teachers' Journal (Israel), No. 20.

    ERIC Educational Resources Information Center

    1978

    This journal contains news items and articles for teachers of English in Israel. The following news items are included: Listening Comprehension Test, 1978; news from the Bagrut Examinations, 1978; summer schools in Great Britain, 1978; Bagrut Examinations, 1975-1978; in-service courses; "English Teachers' Journal" subscription; new…

  11. Senior Faculty Perceptions of Social Work Journals.

    ERIC Educational Resources Information Center

    Cnaan, Ram A.; And Others

    1994-01-01

    A survey of 421 senior faculty in graduate social work education investigated the familiarity and perceived quality of 120 professional journals in the field. Resulting ratings are presented for use by faculty seeking to publish their work in appropriate journals and those assessing the scholarly contribution of social work educators. (Author/MSE)

  12. AFA Support for Research: Journals and Conferences.

    ERIC Educational Resources Information Center

    Sillars, Malcolm O.; Zarefsky, David

    2000-01-01

    Claims the American Forensic Association's (AFA) publications and conferences represent its principal commitment to research. Presents a review of the journals and conferences under AFA sponsorship. Reviews the strong commitment to research on the part of the AFA, particularly as it is manifested in the association's journal and in conferences.…

  13. Journal of Music Teacher Education Yearbook

    ERIC Educational Resources Information Center

    MENC: The National Association for Music Education, 2005

    2005-01-01

    The fall 2004 and spring 2005 issues of Journal of Music Teacher Education, the online journal of MENC's Society for Music Teacher Education, in one print edition, includes a special issue on the future of music education, with articles about certification practices, second-career music teachers, music education philosophy and research for future…

  14. Pedagogisch Tijdschrift (Journal of Pedagogy), 1994.

    ERIC Educational Resources Information Center

    Smeyers, Paul, Ed.; And Others

    1994-01-01

    This 6-issue, complete year of a Belgian-Dutch collaboration offers complete articles on pedagogical subjects, some with an English-language summary; reviews of new Dutch-language books; and titles from related Dutch-language journals. Articles include: "On the Policies of the Journal of Pedagogy" (P. Smeyers); "Pedagogic…

  15. Efficient Journaling for the Spider Storage System

    SciTech Connect

    Oral, H Sarp; Wang, Feiyi; Shipman, Galen M; Dillow, David A; Miller, Ross G; Drokin, Oleg

    2003-01-01

    Journaling is a widely used technique to increase file system robustness against meta data and/or data corruptions. While the overhead of journaling can be negligible for small-scale file systems, we found that two aspects of local back-end file system journaling significantly lower the overall performance of a large-scale parallel file system such as Lustre: extra head seeks and serialization of incoming client requests. Journal transactions reside on a separate area of the disk that the file data, and each commit of the journal requires a head seek. Incoming client requests become serialized and take a latency hit by waiting for a commit to occur before the reply is sent. In this paper we present two different approaches to increase the local back-end file system journaling efficiency, thus increasing the overall aggregate parallel file system efficiency. First, we present a hardware-based solution where a solid-state device is used as an external journaling device to minimize the disk head seek. Second, we introduce a software-based optimization to allow asynchronously commit multiple journal transactions on the local back-end file system to minimize the penalty of serialization. Both our solutions are experimentally tested on Oak Ridge National Laboratory's large-scale Spider storage system and our tests show that both methods nearly double the overall parallel write performance.

  16. Making the Introductory Journalism Class Tick.

    ERIC Educational Resources Information Center

    Dorway, Tim

    2003-01-01

    Proposes that beginning journalism classes teach multiple skills, including law, decision-making, interpersonal communication, interviewing, and critical thinking. Outlines how to convince administrators of the need for beginning journalism classes, and how to develop an effective class. Lists philosophy and course goals for one such class. (PM)

  17. Deep impact: unintended consequences of journal rank

    PubMed Central

    Brembs, Björn; Button, Katherine; Munafò, Marcus

    2013-01-01

    Most researchers acknowledge an intrinsic hierarchy in the scholarly journals (“journal rank”) that they submit their work to, and adjust not only their submission but also their reading strategies accordingly. On the other hand, much has been written about the negative effects of institutionalizing journal rank as an impact measure. So far, contributions to the debate concerning the limitations of journal rank as a scientific impact assessment tool have either lacked data, or relied on only a few studies. In this review, we present the most recent and pertinent data on the consequences of our current scholarly communication system with respect to various measures of scientific quality (such as utility/citations, methodological soundness, expert ratings or retractions). These data corroborate previous hypotheses: using journal rank as an assessment tool is bad scientific practice. Moreover, the data lead us to argue that any journal rank (not only the currently-favored Impact Factor) would have this negative impact. Therefore, we suggest that abandoning journals altogether, in favor of a library-based scholarly communication system, will ultimately be necessary. This new system will use modern information technology to vastly improve the filter, sort and discovery functions of the current journal system. PMID:23805088

  18. Responsibility: The Key to Scholastic Journalism.

    ERIC Educational Resources Information Center

    Bowen, John

    1988-01-01

    To behave responsibly toward school journalism, personnel officers and administrators must select a qualified, fully cognizant adviser/instructor with training in press law and ethics, journalism advising and instruction, news reporting, copy editing, and design and layout principles. A professionally oriented curriculum is also a must. (MLH)

  19. TEACHER'S GUIDE TO HIGH SCHOOL JOURNALISM.

    ERIC Educational Resources Information Center

    JENKINSON, EDWARD B., ED.

    IN AN EFFORT TO TRAIN HIGH SCHOOL STUDENTS TO BECOME INTELLIGENT READERS, LISTENERS, AND VIEWERS OF MASS MEDIA, THE INDIANA STATE DEPARTMENT OF PUBLIC INSTRUCTION PUBLISHED A GUIDE FOR TEACHERS OF JOURNALISM. PART I ESTABLISHES GUIDELINES FOR A FIRST SEMESTER COURSE IN JOURNALISM AND CONTAINS CHAPTERS ON (1) EXPLORING MASS MEDIA, A DISCUSSION OF…

  20. Electronic Journal Delivery in Academic Libraries

    ERIC Educational Resources Information Center

    Crothers, Stephen; Prabhu, Margaret; Sullivan, Shirley

    2007-01-01

    The authors recount experiences of the variety of problems and issues involved in providing access to electronic journals in a large academic library. The paper excludes concerns emanating from decisions to subscribe to aggregations such as those produced by vendors like EBSCO, but concentrates on scholarly journals ordered individually, or as…

  1. LIS Journals in the Knowledge Age.

    ERIC Educational Resources Information Center

    Breen, Eileen

    This paper examines EMERALD LIS and how it facilitates the use of information contained in LIS (library and information science) journals for improvements and progress. EMERALD LIS is a full-text database of journals in information management, library technology, library and information service management, and collection management/development.…

  2. Can Hard Journalism Survive Internet "Reporting"?

    ERIC Educational Resources Information Center

    Bugeja, Michael

    2005-01-01

    Historically, journalism education has fostered its industry ties. Because of state budget cuts, journalism programs must rely increasingly on media companies to sustain the training of students to comfort the afflicted and afflict the comfortable--a century-old maxim tarnished by comfortable media companies' losing sight of their news mission and…

  3. Journal on Excellence in College Teaching. 1990.

    ERIC Educational Resources Information Center

    Cox, Milton D., Ed.; Richlin, Laurie, Ed.

    1990-01-01

    This annual journal's premier issue features the work, thoughts, adventures, and musings of distinguished and respected teachers. An introduction reports that the journal was born of the desire by faculty to recognize college teaching as a profession and to bring to it its own language and traditions and to establish an academic culture for…

  4. Pedagogically-Orientated Language Teaching Journals.

    ERIC Educational Resources Information Center

    Ely, Christopher

    1992-01-01

    Reviews seven pedagogically orientated journals for foreign language teachers, most of which are designed for teachers of English-as-a-Second-Language: (1) "Practical English Teaching"; (2) "Modern English Teacher"; (3) "English Teaching Forum"; (4) "Guidelines"; (5) "ELT Journal"; (6) "Cross Currents"; and (7) "TESL Reporter." The names and…

  5. In Canada: J-School Journal

    ERIC Educational Resources Information Center

    Robertson, Heather-jane

    2004-01-01

    Once or twice each term, the author accepts an invitation to talk with journalism students about current issues in education and how journalists cover education debates. Ottawa's Carleton School of Journalism graduates a substantial proportion of the young people who will soon try to report knowledgeably on a bewildering array of subjects. As…

  6. Potential Physical Disabilities in Computerized Journalism Education.

    ERIC Educational Resources Information Center

    Jackson, Nancy Beth

    Computers, depending on how they are used, can be both a boon and a menace to health and performance. With the increasing presence of computers on campus, journalism educators must make sure they are not creating a new class of disabled persons among their students and disabling themselves in the process. Journalism schools across the United…

  7. "Dear Diary" Revisited: Reflecting on Collaborative Journaling

    ERIC Educational Resources Information Center

    Mackenzie, Catrina A.; Ricker, Britta; Christensen, Julia; Heller, Elizabeth; Kagan, Emily; Osano, Philip M.; Long, Lindsay; Turner, Sarah

    2013-01-01

    The genesis of this article was a request from the "Journal of Geography in Higher Education" to provide a reflection piece about our article 'Dear Diary: Early Career Geographers Collectively Reflect on their Qualitative Field Research Experiences' (2011) that won the journal's biennial award for 2009-2011. This request has afforded us…

  8. Gaining Strength from Experience: The Personal Journal.

    ERIC Educational Resources Information Center

    Glover, Polly S.

    This essay considers the many benefits of journal writing. It explains how one person learned, during a 26-mile commute, to talk into a tape recorder slowly, leaving sizable pauses between phrases to facilitate transcription later on; how journal writing is a way to catch moments in the day, to describe a scene or to make connections that one…

  9. Forensic Journal, Volume VI, January 1984.

    ERIC Educational Resources Information Center

    Forensic Journal, 1984

    1984-01-01

    While covering various English language forensics activities in Japan, this special journal issue is heavily devoted to debate. The 22 articles in the journal are divided into five sections as follows: (1) general information on the Japan English Forensics Association (JEFA); (2) debate, including reports on debate tournaments around the world, a…

  10. The Moral Education of Journal Editors

    ERIC Educational Resources Information Center

    Krimsky, Sheldon

    2010-01-01

    Refereed journals in science and medicine are the gatekeepers and repositories of knowledge in their respective fields. Research reported in peer-reviewed journals builds professional careers, determines which drugs and medical devices are licensed, influences what medical treatments become standards of care, and establishes the veracity of…

  11. A Comprehensive Analysis of Marketing Journal Rankings

    ERIC Educational Resources Information Center

    Steward, Michelle D.; Lewis, Bruce R.

    2010-01-01

    The purpose of this study is to offer a comprehensive assessment of journal standings in Marketing from two perspectives. The discipline perspective of rankings is obtained from a collection of published journal ranking studies during the past 15 years. The studies in the published ranking stream are assessed for reliability by examining internal…

  12. Surviving the War: A College Counselor's Journal

    ERIC Educational Resources Information Center

    Clinton, Philip L.

    2012-01-01

    This article presents excerpts of the author's journal that recounts his experiences and the events about surviving the war in Egypt from 1990-1991. The article begins with the August 13th entry in the journal of the year 1990.

  13. OATYC Journal, Fall 1990-Spring 1991.

    ERIC Educational Resources Information Center

    Fullen, Jim, Ed.

    1991-01-01

    Published by the Ohio Association of Two-Year Colleges, the "OATYC Journal" is designed to provide a medium for sharing concepts, methods, and findings relevant to the classroom, and an open forum for the discussion and review of problems. This 16th volume of the journal, consisting of the fall 1990 and spring 1991 issues, contains the…

  14. Pluralizing Journalism Education: A Multicultural Handbook.

    ERIC Educational Resources Information Center

    Martindale, Carolyn, Ed.

    This book presents the following 24 essays and articles on pluralizing journalism education, with a focus on recruitment, curriculum, and student media: (1) "A Rationale for Pluralizing Journalism Education" (John F. Greenman); (2) "Philosophical and Economic Arguments for Media Diversity" (Ted Pease); (3) "History of Standard 12: Establishing…

  15. 1973-74 Accredited Programs In Journalism.

    ERIC Educational Resources Information Center

    American Council on Education for Journalism.

    The American Council on Education for Journalism (ACEJ), representing both educational and professional media organizations, is the formally recognized agency for the accreditation of programs for professional education in journalism and mass communications in institutions of higher learning in the United States. This ACEJ pamphlet provides…

  16. Broadcast Journalism Education and the Capstone Experience

    ERIC Educational Resources Information Center

    Tanner, Andrea; Forde, Kathy Roberts; Besley, John C.; Weir, Tom

    2012-01-01

    This study assesses the current state of the television news capstone experience in accredited journalism and mass communication programs in the United States. Specifically, the authors employed a mixed-methods approach, interviewing 20 television news capstone instructors and conducting an analysis of broadcast journalism curriculum information…

  17. The Changing Faces of ASE Journals

    ERIC Educational Resources Information Center

    Hanrott, Jane, Comp.

    2013-01-01

    Over the past 50 years, the Association for Science Education (ASE) has published a wide range of journals as a principal benefit of membership of the Association, with some reaching beyond the membership. This article explores the history behind each of the four current ASE journals, as well as touching on two titles that "served their…

  18. A Registry of Archived Electronic Journals

    ERIC Educational Resources Information Center

    Sparks, Sue; Look, Hugh; Bide, Mark; Muir, Adrienne

    2010-01-01

    Concerns about e-journal archiving have increased in recent years. There is no central list of archived titles and there are inconsistencies in the information available about them. This makes it difficult for journal collection managers to take decisions on discarding print back runs and moving to electronic only subscriptions. In 2007, the UK's…

  19. Student-Selected Journals: An Emerging Resource

    ERIC Educational Resources Information Center

    Weber, Roberta K.; Allen, Ethan J.

    2014-01-01

    This longitudinal study investigates the journal selections of 367 graduate students as they worked to fulfill a commonly assigned, criteria-based literature search on educational topics. The criteria called for evidence-based studies, published within the current ten years of course enrollment, within peer-reviewed journals. Student references…

  20. Electronic Journals, the Internet, and Scholarly Communication.

    ERIC Educational Resources Information Center

    Kling, Rob; Callahan, Ewa

    2003-01-01

    Examines the role of the Internet in supporting scholarly communication via electronic journals. Topics include scholarly electronic communication; a typology of electronic journals; models of electronic documents and scholarly communication forums; publication speed; costs; pricing; access and searching; citations; interactivity; archiving and…

  1. Accuracy of References in Five Entomology Journals.

    ERIC Educational Resources Information Center

    Kristof, Cynthia

    ln this paper, the bibliographical references in five core entomology journals are examined for citation accuracy in order to determine if the error rates are similar. Every reference printed in each journal's first issue of 1992 was examined, and these were compared to the original (cited) publications, if possible, in order to determine the…

  2. Journal Evaluation in a Large Research Library

    ERIC Educational Resources Information Center

    Wanger, Charles B.; Childress, Judith

    1977-01-01

    A journal evaluation study was conducted at the National Oceanic and Atmospheric Administration (NOAA) libraries to assist in subscription renewals, collection relevance enhancement, and determination of efficient methodology. Data collection included a use study, circulation and inter-library loan statistics, core journals, questionnaires, costs,…

  3. Academic Library Responses to Journal Price Discrimination.

    ERIC Educational Resources Information Center

    Haley, Jean Walstrom; Talaga, James

    1992-01-01

    Discusses the nature and extent of discriminatory pricing by journal publishers, and reports on a survey of academic libraries that was conducted to assess the effectiveness of strategies used by libraries to mitigate the effects of high journal prices and price discrimination, i.e., higher prices for both institutions and foreign subscribers.…

  4. Journal Editorship: Mentoring, Democratic, and International Perspectives

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2011-01-01

    This essay builds on a review of studies in education. Journal editorship is explored from the mentoring, democratic, and international perspectives. Trends are examined within the publishing culture around these three editorial functions. Theoretical groundwork is provided for exploring contemporary journal editorship and its challenges and…

  5. Content Analysis of Articles Published in Iranian Scientific Nursing Journals From 2009 Through 2011

    PubMed Central

    Tahamtan, Iman; Bagheri, Zeinab; Janani, Payman; Majidi, Somayye; Ghasemi, Elham; Negarandeh, Reza

    2014-01-01

    Background: Little is known about the features of Iranian nursing journals, specifically the subject areas used in articles, study designs, sampling methods, international collaboration of Iranian nursing scholars, specialty and academic rank of authors, and the most frequently contributing academic institutions in articles. Objectives: The aim of this study was to analyze the content of the articles published in Iranian scientific nursing journals. Materials and Methods: Quantitative content analysis was implemented to study Iranian nursing journals, which were approved by the commission for accreditation and improvement of Iranian medical journals in 2011. Thus, 763 articles from six journals, published from 2009 through 2011, were investigated. Data were extracted from the abstracts and when necessary, from the full-text of articles by visiting the websites of these journals. Descriptive statistics were used to analyze the data. Results: The main subjects of published articles in Iranian scientific nursing journals were consecutively renal dialysis (n = 21), intensive care unit (n = 16), nursing education (n = 15), patient satisfaction (n = 13), quality of life (n = 12), health education (n = 11), patient education (n = 11), pain (n = 10), and education (n = 9). The majority of authors had nursing and midwifery specialty (52.59%) followed by epidemiology/biostatistics specialty (7.72%). Isfahan, Tehran, Shahid Beheshti, Iran, Baqiyatallah, and Urmia universities of medical sciences had consecutively the largest number of publications in the studied journals. Only three papers (0.39%) were published by the international collaboration. Conclusions: Iranian nursing journals should publish special issues in the neglected subject areas. These journals should encourage authors to publish research evidence with higher quality. PMID:25741512

  6. A method for assessing reflective journal writing.

    PubMed

    Plack, Margaret M; Driscoll, Maryanne; Blissett, Sylvene; McKenna, Raymond; Plack, Thomas P

    2005-01-01

    Reflection is widely accepted as a learning tool and is considered integral to professional practice. Journal writing is advocated in facilitating reflection, yet little is written about how to assess reflection in journals. The purpose of this study was to develop and test a method of assessing the elements of reflection in journals and to determine whether, and to what level, reflection occurs in journals. Twenty-seven physical therapy students maintained written reflective journals throughout three of their four eight-week clinical affiliations. The students were introduced to concepts of reflective practice with definitions of terms and reflective questions before their second affiliation. A coding schema was developed to assess the journals. Three raters assessed forty-three journals. The text of each journal was analyzed for evidence of nine elements of reflection, and each journal was categorized as showing no evidence of reflection, evidence of reflection, or evidence of critical reflection. Descriptive statistics were used to demonstrate evidence of reflection. Reliability between each pair of raters was assessed using percent agreement, phi coefficients, and gamma statistics. Interrater reliability of all raters was assessed using intraclass correlation coefficients (ICC[2,1]). Results showed that the raters assessed 95.3%-100% of the journals as showing at least one element of reflection. The percent agreement between rater pairs for the nine elements of reflection ranged from 65.1% to 93.0%, the phi coefficient ranged from 0.08 to 0.81, and the ICC(2,1) values used to assess reliability among the three raters on each element ranged from 0.03 to 0.72. Averaging the assessment of the three raters for the overall journal, 14.7% of the journals were assessed as showing no evidence of reflection, 43.4% as showing evidence of reflection, and 41.9% as showing evidence of critical reflection. The percent agreement between rater pairs for the overall assessment

  7. Examining Marketing Journals' Publication Process and Reviewer Practices

    ERIC Educational Resources Information Center

    Seiler, Vicky L.; Reisenwitz, Timothy H.; Schibrowsky, John A.

    2011-01-01

    This study examines reviewer practices at 11 marketing journals. The results for the top three journals are compared to eight comparable journals that are typically considered to be non-top-tier journals. The results suggest that the reviewers and the review processes at the top journals differ significantly from those of the non-top-tier…

  8. Evaluating Academic Journals without Impact Factors for Collection Management Decisions.

    ERIC Educational Resources Information Center

    Dilevko, Juris; Atkinson, Esther

    2002-01-01

    Discussion of evaluating academic journals for collection management decisions focuses on a methodological framework for evaluating journals not ranked by impact factors in Journal Citation Reports. Compares nonranked journals with ranked journals and then applies this framework to a case study in the field of medical science. (LRW)

  9. Physical Review: a family of journals

    NASA Astrophysics Data System (ADS)

    Sprouse, Gene

    2013-03-01

    The expansion of research in physics in the last 100 years has been reflected in the expansion of the Physical Review(PR). Reviews of Modern Physics was the first ``new'' journal, starting in 1929. Physical Review Letters commenced in 1958, and was the first ``letters'' type of journal for important new results in all fields. By 1970 the Physical Review itself had grown so large that it was necessary to separate it by field into manageable volumes: PRA, PRB, PRC and PRD, and subsequently PRE, which was split off from PRA. More recently, two Special Topics journals for accelerator physics and physics education were pioneers of the open access business model, and the newest member of the family, Physical Review X, continues this trend. PRX is broad scope and very selective, setting it well above many of the new open access journals with a review standard of ``not incorrect.'' Some possible future directions for the Physical Review journals will be discussed.

  10. [E-learning with journal articles].

    PubMed

    Adriaanse, Marcel T; van Eijsden, Pieter; de Leeuw, Peter W

    2014-01-01

    E-learning is a popular method of continuous medical education (CME) which is becoming increasingly available to doctors. A specific form of E-learning is an online knowledge test accompanying a journal article. CME accreditation points can be obtained by reading an article and then answering test questions on it. This is a user-friendly form of CME which an increasing number of journals are offering as a service to their readers. The Dutch Journal of Medicine (NTvG) has been offering accredited tests to its readers since 2011. On comparison with international journals, a high standard has been set by the development of a test concept in which interpretation and reflection play integral roles. In the Dutch setting, the concept of the test was developed by professional bodies working closely together and it is a concept that is used as an example to other journals.

  11. Chinese journals: a guide for epidemiologists

    PubMed Central

    Fung, Isaac CH

    2008-01-01

    Chinese journals in epidemiology, preventive medicine and public health contain much that is of potential international interest. However, few non-Chinese speakers are acquainted with this literature. This article therefore provides an overview of the contemporary scene in Chinese biomedical journal publication, Chinese bibliographic databases and Chinese journals in epidemiology, preventive medicine and public health. The challenge of switching to English as the medium of publication, the development of publishing bibliometric data from Chinese databases, the prospect of an Open Access publication model in China, the issue of language bias in literature reviews and the quality of Chinese journals are discussed. Epidemiologists are encouraged to search the Chinese bibliographic databases for Chinese journal articles. PMID:18826604

  12. New journals for publishing medical case reports.

    PubMed

    Akers, Katherine G

    2016-04-01

    Because they do not rank highly in the hierarchy of evidence and are not frequently cited, case reports describing the clinical circumstances of single patients are seldom published by medical journals. However, many clinicians argue that case reports have significant educational value, advance medical knowledge, and complement evidence-based medicine. Over the last several years, a vast number (∼160) of new peer-reviewed journals have emerged that focus on publishing case reports. These journals are typically open access and have relatively high acceptance rates. However, approximately half of the publishers of case reports journals engage in questionable or "predatory" publishing practices. Authors of case reports may benefit from greater awareness of these new publication venues as well as an ability to discriminate between reputable and non-reputable journal publishers.

  13. New journals for publishing medical case reports

    PubMed Central

    Akers, Katherine G.

    2016-01-01

    Because they do not rank highly in the hierarchy of evidence and are not frequently cited, case reports describing the clinical circumstances of single patients are seldom published by medical journals. However, many clinicians argue that case reports have significant educational value, advance medical knowledge, and complement evidence-based medicine. Over the last several years, a vast number (∼160) of new peer-reviewed journals have emerged that focus on publishing case reports. These journals are typically open access and have relatively high acceptance rates. However, approximately half of the publishers of case reports journals engage in questionable or “predatory” publishing practices. Authors of case reports may benefit from greater awareness of these new publication venues as well as an ability to discriminate between reputable and non-reputable journal publishers. PMID:27076803

  14. Perils and positives of science journalism in Australia.

    PubMed

    McKinnon, Merryn; Howes, Johanna; Leach, Andrew; Prokop, Natasha

    2017-03-01

    Scientists, science communicators and science journalists interact to deliver science news to the public. Yet the value of interactions between the groups in delivering high-quality science stories is poorly understood within Australia. A recent study in New Zealand on the perspectives of the three groups on the challenges facing science journalism is replicated here in the context of New South Wales and the Australian Capital Territory. While all three groups perceived the quality of science journalism as generally high, the limitations of non-specialists and public relation materials were causes for concern. The results indicate that science communicators are considered to play a valuable role as facilitators of information flow to journalists and support for scientists. Future studies on the influence and implications of interactions between these three groups are required.

  15. Seeing Physics Outside the Classroom Through Journal Writing

    NASA Astrophysics Data System (ADS)

    Hopp, J. Johanna

    2006-12-01

    As educators, we want students to realize the importance of physics in their everyday lives. Furthermore, we want to provide students an opportunity to experience physics outside the classroom to reinforce the material we discuss inside the classroom. This poster describes a journal writing assignment that accomplishes both these things for use in introductory physics courses. Students write journals about the physics they experience in their ‘real’ lives. The entries are brief, with a sentence or two describing an observation they made and a few sentences discussing the physics that is involved. Students are encouraged to write about events that involve physical principles discussed in class. This allows the instructor to determine if there are misconceptions about topics. This assignment has been received positively by students and is enjoyable for the instructor. It provides the instructor insights about the students’ experiences and thought processes as they relate to physics.

  16. Publishing scientific journals in the digital age: opportunities for small scholarly journals.

    PubMed

    Marušić, Ana

    2014-01-01

    Scientific publishing is rapidly developing from print-only to digital journals and extensive use of social media. This essay presents our experience in developing a small and scholarly journal from the so-called scientific semi-periphery and using the advantages of digital publishing to increase the visibility of the journal in international indexing and citation databases, and ensure greater visibility in the global scientific community. An editor of a scientific journal does not need to master all details of different digital publishing tools, but needs to follow the developments so that they can be best implemented in the journal.

  17. A comparison of citations across multidisciplinary psychology journals: a case study of two independent journals.

    PubMed

    Schumm, Walter R

    2010-02-01

    Citation rates and impact factors are often used in an attempt to evaluate the apparent prestige of scholarly journals and the quality of research published by individual scholars. However, the apparent prestige of "top tier" journals may reflect aggressive marketing and advertising efforts as much as scholarship. Some journals have retained their independence from professional organizations and the funding, marketing, and advocacy policies that may be associated with such organizations. While lacking as much visibility as organizational journals and sometimes considered "lower tier," independent journals may be able to provide comparable scientific quality as measured by citation rates. To test this, the citation rates of 169 articles published by a frequently cited scholar were compared across first- and second-tier journals, including many sponsored and marketed by large professional organizations, and to rates for two independent journals combined, Psychological Reports and Perceptual and Motor Skills. Citation rates were higher for first-tier journals but for most comparisons, especially those that controlled for heterogeneity of variance, results did not differ in statistically significant ways among the three tiers of journals, though some nonsignificant trends (p < .15) were found. If citation rates of articles are any indication of scientific quality, tiered classifications of journals appear to be a relatively weak indicator of scientific merit; journals at any tier contain articles that are useful and of good quality.

  18. Posting (Transferring) Entries from Journals to Ledgers. Student Manual and Instructor's Manual.

    ERIC Educational Resources Information Center

    McElveen, Peggy C.

    Supporting performance objective 34 of the V-TECS (Vocational-Technical Education Consortium of States) Secretarial Catalog, both a set of student materials and an instructor's manual on posting (transferring) entries from journals to ledgers are included in this packet, which is one of a set. The student materials include a cash receipts journal…

  19. The distribution of forensic journals, reflections on authorship practices, peer-review and role of the impact factor.

    PubMed

    Jones, Alan Wayne

    2007-01-17

    This article presents information about journals specializing in the forensic sciences and legal medicine, their development and distribution and their current status as reflected in the journal impact factor. The first scientific journal devoted to spreading information and reporting new developments in social and legal medicine seemingly originated in Germany about 150 years ago. The official journal of the American Academy of Forensic Sciences (Journal of Forensic Sciences, JFS) was founded in 1956 and has enjoyed 50 years of scholarly publishing. The two leading European journals specializing in forensics are Forensic Science International (FSI) and International Journal of Legal Medicine (IJLM). Besides the size of the circulation, the readership numbers, the quality of the editorial staff and the peer-reviewers, the number of submitted and accepted manuscripts, considerable interest has focused on the journal's impact factor as a measure of prestige. The 2006 impact factor of a certain journal is derived by counting the number of citations in 2006 to all material published in the journal in the previous 2 years (2004 and 2005) and dividing this total by the number of citable items (articles and reviews) published in the same 2 years. Impact factors for several thousand scientific journals are compiled and published by a company called Thomson Institute for Scientific Information (Thomson ISI) and are available on-line via the database Journal Citation Reports. Forensic journals are grouped within the subject category Medicine, Legal, which currently comprises nine journals a few of which are seemingly unrelated to mainstream forensics. The top-ranked forensic journal in terms of its impact factor was IJLM with a score of just over 2.0 in 2004. This means that the average article published in 2003 and 2002 was cited twice per year in the 2-year window after publication. Impact factors of forensic journals are fairly low in comparison with many other

  20. Journal of Chemical Education on CD-ROM, 1999

    NASA Astrophysics Data System (ADS)

    1999-12-01

    The Journal of Chemical Education on CD-ROM contains the text and graphics for all the articles, features, and reviews published in the Journal of Chemical Education. This 1999 issue of the JCE CD series includes all twelve issues of 1999, as well as all twelve issues from 1998 and from 1997, and the September-December issues from 1996. Journal of Chemical Education on CD-ROM is formatted so that all articles on the CD retain as much as possible of their original appearance. Each article file begins with an abstract/keyword page followed by the article pages. All pages of the Journal that contain editorial content, including the front covers, table of contents, letters, and reviews, are included. Also included are abstracts (when available), keywords for all articles, and supplementary materials. The Journal of Chemical Education on CD-ROM has proven to be a useful tool for chemical educators. Like the Computerized Index to the Journal of Chemical Education (1) it will help you to locate articles on a particular topic or written by a particular author. In addition, having the complete article on the CD-ROM provides added convenience. It is no longer necessary to go to the library, locate the Journal issue, and read it while sitting in an uncomfortable chair. With a few clicks of the mouse, you can scan an article on your computer monitor, print it if it proves interesting, and read it in any setting you choose. Searching and Linking JCE CD is fully searchable for any word, partial word, or phrase. Successful searches produce a listing of articles that contain the requested text. Individual articles can be quickly accessed from this list. The Table of Contents of each issue is linked to individual articles listed. There are also links from the articles to any supplementary materials. References in the Chemical Education Today section (found in the front of each issue) to articles elsewhere in the issue are also linked to the article, as are WWW addresses and email

  1. The Health of School Children: Contributions from American Medical Journals, July, 1913, to July, 1914. Bulletin, 1915, No. 4. Whole Number 628

    ERIC Educational Resources Information Center

    Heck, W. H., Comp.

    1915-01-01

    Medical journals are not often accessible to students and practitioners of education, and therefore the wealth of material in these journals regarding the health of school children is mainly lost to the educational world. The present bulletin is the result of a desire to put this material at the disposal of superintendents, principals, professors,…

  2. Experiments in Creative Climate Journalism

    NASA Astrophysics Data System (ADS)

    Kintisch, E. S.

    2011-12-01

    Creative experiments in climate journalism are my aim during a one year fellowship at a university. The goal is to engage the audience's senses, mind, and hopefully, imagination in work about Earth's climate. The work is done in collaboration with students, artists, scientists, musicians and actors, all marshalled to explain how the warming planet works through engaging and innovative means. This session will feature video examples of using design or music to visualize climate data. A video using improvisational actors drinking Red Bull to bring the concept of climate sensitivity to life will be shown. A glossy card designed to spoof an airline safety instruction card will be displayed; its design explains geoengineering techniques and their risks. In doing this work I have benefitted from a fellowship at Massachusetts Institute for Technology, which has provided the precious gift of time and creative atmosphere. I am on leave from Science magazine. I will report on what has and hadn't worked in fostering new means of communicating science in an academic setting. The session will also explore the shifting role of the journalist in this new space. The challenges take me beyond simply using words as a medium between science and the public. I find myself as a convener or producer in engendering partnerships between scientists and great communicators like actors, sculptors or filmmakers.

  3. Biomedical journals: keeping up and reading critically.

    PubMed

    Chase, Karen L; DiGiacomo, Ronald F; Van Hoosier, Gerald L

    2006-09-01

    By extrapolation from studies of physicians, knowledge and practice of laboratory animal medicine and science are expected to become progressively more outdated the longer practitioners are out of school. Keeping up with current literature and practice is a challenge that necessitates the use of many different sources of continuing education. Both veterinarians and physicians consistently list journals as the most beneficial source of new information. Accordingly, they must select from the veterinary and biomedical literature articles that report original studies and systematic reviews and recognize and respond to valid new knowledge to improve diagnostic and therapeutic approaches and maintain consistent clinical skills. Other objectives include selecting journals for general information and for information relevant or specific to one's field of research. Lastly, candidates for board certification need to read articles from journals that potentially provide the basis for questions on the examination. 'High-impact' journals should be identified, and articles should be reviewed critically. In a survey of recent candidates for laboratory animal medicine board examination, these journals included Contemporary Topics (now JAALAS), Comparative Medicine, ILAR Journal, and Laboratory Animals. Strategies for coping with the challenge of staying current with the literature include wise use of technology, journal clubs, and consultation with colleagues. A laboratory animal practitioner can become a better scientist and clinician by evaluating the research performed by others. Thorough, critical review of biomedical literature is paramount to these goals.

  4. Reflections on 25 Years of Journal Editorship

    NASA Astrophysics Data System (ADS)

    Matthews, Michael R.

    2015-07-01

    These reflections range over some distinctive features of the journal Science & Education, they acknowledge in a limited way the many individuals who over the past 25 years have contributed to the success and reputation of the journal, they chart the beginnings of the journal, and they dwell on a few central concerns—clear writing and the contribution of HPS to teacher education. The reflections also revisit the much-debated and written-upon philosophical and pedagogical arguments occasioned by the rise and possible demise of constructivism in science education.

  5. Science and journalism: friend or foe?

    NASA Astrophysics Data System (ADS)

    Mosoia, Cătălin

    2011-06-01

    A journalist's view on science and journalism. The presentation is based on personal experience gained over the past few years as editor of the minute of science broadcasted at Radio Europa FM, Bucharest, Romania, and as editor and writer for the Romanian electronic science newspaper Ziarul stiintelor. Is it possible to have science with or without journalism? Who is waiting for whom, science or journalism? Is astronomy more attractive to the public than other disciplines? Can it be used as a growing factor for the public understanding of science?

  6. AGU Journals Increase Speed and Impact

    NASA Astrophysics Data System (ADS)

    Warner, Mary

    2014-08-01

    Fast publication and high quality and impact are important for effective dissemination of geoscience research. With this in mind, AGU's journal editors and staff, along with staff at our publishing partner, Wiley, have been working to increase both the speed of publication and the impact of the research published in our 18 peer-reviewed journals while maintaining our commitment to quality. Significant progress continues to be made on both fronts, as evidenced by the most recent publication times and the 2013 release of the Journal Citation Reports®, which was issued by Thomson Reuters on 29 July.

  7. What Medical Journal Editing Means to Me

    PubMed Central

    Marcovitch, Harvey

    2008-01-01

    Papers in medical journals are often difficult to understand and tedious to read. An editor's first loyalty should be to readers, by prioritising readability over merely producing a repository of data for the scientific community generally. The web now provides infinite repository space so there is even less excuse for journals to be unreadable. I give examples of how I attempted to improve one journal, despite external pressures and regardless of how it might affect the Impact Factor. As a postscript I outline increasing involvement in promoting honesty and integrity in publishing through the auspices of the Committee on Publication Ethics (COPE). PMID:22013361

  8. [Composite editorial contents in French chemical journals].

    PubMed

    Dalbin, Sylvie

    2014-01-01

    This study of a corpus of French chemistry journals between 1800 and 2010 shows the relevance of the journal as the primary mode of communication, confirming the results of the general survey presented in this issue. However, a study of their contents is questioning the apparent unity of this phenomenon: the journal appears as a physical medium consisting in a common container including a wide range of information categories transferred over time to digital platforms in development since the end of the 20(th) century.

  9. Is journalism failing on climate?

    NASA Astrophysics Data System (ADS)

    Rahmstorf, Stefan

    2012-12-01

    How can we build a reliable and affordable energy supply based on renewables? How rapidly do we need to cut greenhouse gas emissions to keep climate change within manageable bounds? What does it take to maintain a stable common currency of different nations? These are just a few examples of questions that are critical for our future and that require an understanding of complex systems—the energy system, the climate system, the financial system. Finding sound answers to these questions requires sophisticated scientific analysis and expert knowledge; a lay person's intuition will clearly not suffice. Yet, decisions in a democracy are (and should be!) taken by politicians and the voting public who are not usually scientific experts. Hence the well-being of our societies—and even more so the living conditions of future generations, which are defined by the decisions we take today—depends on the wider public being well informed about the state of scientific knowledge and discourse. The media are the most important means by which lay people obtain their information about science. Good science journalism is therefore a decisive factor for the long-term success of modern society. Good science journalism clearly must be critical journalism, and it requires journalists who know what is what, who can put things into a perspective, and who are able to make well-informed judgements. After all, the role of science journalism is not simply to act as a 'translator' who conveys the findings of scientists in a language understandable to lay people. Rather, good science journalism will provide the public with a realistic impression of what is well established in science and what are current 'hot topics', uncertainties and controversies. It will also discuss the methods and social context of the scientific endeavour. There is ample evidence that in the area of climate science, journalism too often is failing to deliver this realistic picture to its audience, despite many good

  10. One Hundred Years of the Journal of Applied Psychology: Background, Evolution, and Scientific Trends.

    PubMed

    Kozlowski, Steve W J; Chen, Gilad; Salas, Eduardo

    2017-02-16

    To launch this Special Issue of the Journal of Applied Psychology celebrating the 1st century of the journal we conducted a review encompassing the background of the founding of the journal; a quantitative assessment of its evolution across the century; and an examination of trends examining article type, article length, authorship patterns, supplemental materials, and research support. The journal was founded in March of 1917 with hopeful optimism about the potential of psychology being applied to practical problems could enhance human happiness, well-being, and effectiveness. Our quantitative content assessment using both keyword frequencies and latent semantic analyses of raw content, in both bottom-up (corpus driven) and top-down modes (analyst driven), converged to document an evolution ranging from a broad and exploratory applied psychology to a more focused industrial psychology to an industrial and organizational psychology to an organizational psychology. With respect to other trends, during the first 4 decades 20 to 30% of journal items were book reviews, which then abruptly ceased in the mid-1950s. Articles have grown increasingly longer over time. Author teams are increasingly larger, and sole authored articles are vanishingly small in frequency. The use of supplemental materials and articles reporting research support have surged dramatically in the most recent period. Across the various foci we examined, our review portrays the evolution of the journal as reflecting the development of a mature, focused, and cumulative scientific discipline addressing psychological science applied to work and organizations. (PsycINFO Database Record

  11. Engineering Education Research in "European Journal of Engineering Education" and "Journal of Engineering Education": Citation and Reference Discipline Analysis

    ERIC Educational Resources Information Center

    Wankat, Phillip C.; Williams, Bill; Neto, Pedro

    2014-01-01

    The authors, citations and content of "European Journal of Engineering Education" ("EJEE") and "Journal of Engineering Education" ("JEE") in 1973 ("JEE," 1975 "EJEE"), 1983, 1993, 2003, and available 2013 issues were analysed. Both journals transitioned from house organs to become…

  12. Fate of Manuscripts Rejected From the Red Journal

    SciTech Connect

    Holliday, Emma B.; Yang, George; Jagsi, Reshma; Hoffman, Karen E.; Bennett, Katherine Egan; Grace, Calley; Zietman, Anthony L.

    2015-01-01

    Purpose: To evaluate characteristics associated with higher rates of acceptance for original manuscripts submitted for publication to the International Journal of Radiation Oncology • Biology • Physics (IJROBP) and describe the fate of rejected manuscripts. Methods and Materials: Manuscripts submitted to the IJROBP from May 1, 2010, to August 31, 2010, and May 1, 2012, to August 31, 2012, were evaluated for author demographics and acceptance status. A PubMed search was performed for each IJROBP-rejected manuscript to ascertain whether the manuscript was ultimately published elsewhere. The Impact Factor of the accepting journal and the number of citations of the published manuscript were also collected. Results: Of the 500 included manuscripts, 172 (34.4%) were accepted and 328 (65.6%) were rejected. There was no significant difference in acceptance rates according to gender or degree of the submitting author, but there were significant differences seen based on the submitting author's country, rank, and h-index. On multivariate analysis, earlier year submitted (P<.0001) and higher author h-index (P=.006) remained significantly associated with acceptance into the IJROBP. Two hundred thirty-five IJROBP-rejected manuscripts (71.7%) were ultimately published in a PubMed-listed journal as of July 2014. There were no significant differences in any submitting author characteristics. Journals accepting IJROBP-rejected manuscripts had a lower median [interquartile range] 2013 impact factor compared with the IJROBP (2.45 [1.53-3.71] vs 4.176). The IJROBP-rejected manuscripts ultimately published elsewhere had a lower median [interquartile range] number of citations (1 [0-4] vs 6 [2-11]; P<.001), which persisted on multivariate analysis. Conclusions: The acceptance rate for manuscripts submitted to the IJROBP is approximately one-third, and approximately 70% of rejected manuscripts are ultimately published in other PubMed-listed journals, but these ultimate

  13. Application of computational fluid dynamics on cavitation in journal bearings

    NASA Astrophysics Data System (ADS)

    Riedel, Marco; Schmidt, Marcus; Reinke, Peter; Nobis, Matthias; Redlich, Marcel

    2014-03-01

    Journal bearings are applied in internal combustion engines due to their favourable wearing quality and operating characteristics. Under certain operating conditions damage of the journal bearing can occur caused by cavitation. The cavitation reduces the load capacity and leads to material erosion. Experimental investigations of cavitating flows in dimension of real journal bearing are difficult to realize or almost impossible caused by the small gap and transient flow conditions. Therefore numerical simulation is a very helpful engineering tool to research the cavitation behaviour. The CFD-Code OpenFOAM is used to analyse the flow field inside the bearing. The numerical cavitation model based on a bubble dynamic approach and requires necessary initial parameter for the calculation, such as nuclei bubble diameter, the number of nuclei and two empirical constants. The first part of this paper shows the influence of these parameters on the solution. For the adjustment of the parameters an experiment of Jakobsson et.al. [1] was used to validate the numerical flow model. The parameters have been varied according to the method Design of Experiments (DoE). With a defined model equation the parameters determined, to identify the parameter for CFD-calculations in comparison to the experimental values. The second part of the paper presents investigations on different geometrical changes in the bearing geometry. The effect of these geometrical changes on cavitation was compared with experimental results from Wollfarth [2] and Garner et.al. [3].

  14. Median Citation Index vs Journal Impact Factor

    NASA Astrophysics Data System (ADS)

    Antonoyiannakis, Manolis

    2015-03-01

    The Journal Impact Factor is an arithmetic mean: It is the average number of citations, in a year, to a journal's articles that were published the previous two years. But for the vast majority of scholarly journals, the distribution of these citations is skewed (non-symmetric). We argue that a more representative member of the skewed distribution of citations is its median, not the mean. We thus introduce the Median Citation Index (MCI) and compare it to the journal Impact Factor (JIF) as a potentially more suitable choice of the ``center'' of the distribution, or its typical value. Unlike the JIF, the MCI is far less sensitive to outlier (very highly cited) papers or to gaming, and does not lend itself to the hype of calculating it to three decimal digits.

  15. Research Review: Issues in Magazine Journalism Education.

    ERIC Educational Resources Information Center

    King, Elliot

    1994-01-01

    Argues that, hobbled by an impoverished underlying model and a lack of resources, very little empirical research has explored magazine journalism education. Investigates the underlying model, reviews existing research, and offers an optimistic assessment about future research possibilities. (SR)

  16. Reporting research in medical journals and newspapers.

    PubMed Central

    Entwistle, V.

    1995-01-01

    Newspapers are important sources of information about medical advances for many lay people and can influence those working in the health service. Medical journalists on newspapers routinely use general medical journals to obtain information on research. The Lancet and BMJ are both examined carefully by broadsheet journalists in Britain each week. These papers published an average of 1.25 stories from these journals every Friday. The stories focused on serious diseases, topical health problems, and new treatments rather than social problems. The newspaper stories were based on the full research article and not the journals' press releases, although the press releases were valued as early information. Journalists relied heavily on the peer review processes of the journals in ensuring accuracy. PMID:7719187

  17. Print Journalism: It's a "Kidsworld," Too!

    ERIC Educational Resources Information Center

    Speight, Clegg D.

    1979-01-01

    Outlines procedures followed by seventh- and eighth-grade journalism students at the military dependent school at Myrtle Beach Air Force Base, South Carolina, in publishing an award-winning newspaper. (GT)

  18. Getting published in peer-reviewed journals.

    PubMed

    Dimitroulis, G

    2011-12-01

    Writing a paper for publication in a peer-reviewed journal is a rewarding experience but a very difficult undertaking that requires years of experience, determination and patience. The exponential rise of knowledge has resulted in the exponential rise of manuscripts submitted for publication in the various peer-reviewed journals all over the world. Potential authors are not only having to write high-quality papers to get published, but also have to compete with other authors for the limited journal space available to publish their papers. The purpose of this article is to highlight some of the ways of making the task of getting published in peer-reviewed journals easier to achieve.

  19. Interdisciplinary Research and the Journalism Historian

    ERIC Educational Resources Information Center

    Ward, Jean

    1978-01-01

    Points out the need for histories that take mass communication as their subject and include journalism as a part of that larger topic; describes concerns shared by mass communication history and the field of American studies. (GW)

  20. Summary Report of Journal Operations, 2006

    ERIC Educational Resources Information Center

    American Psychologist, 2007

    2007-01-01

    This article provides a summary report of American Psychological Association journal operations, 2006. This summary is compiled from the 2006 annual reports of the Council of Editors and from Central Office records.

  1. Comparison between Impact factor, SCImago journal rank indicator and Eigenfactor score of nuclear medicine journals.

    PubMed

    Ramin, Sadeghi; Sarraf Shirazi, Alireza

    2012-08-27

    Despite its widespread acceptance in the scientific world, impact factor (IF) has been criticized recently on many accounts: including lack of quality assessment of the citations, influence of self citation, English language bias, etc. In the current study, we evaluated three indices of journal scientific impact: (IF), Eigenfactor Score (ES), and SCImago Journal rank indicator (SJR) of nuclear medicine journals. Overall 13 nuclear medicine journals are indexed in ISI and SCOPUS and 7 in SCOPUS only. Self citations, Citations to non-English articles, citations to non-citable items and citations to review articles contribute to IFs of some journals very prominently, which can be better detected by ES and SJR to some extent. Considering all three indices while judging quality of the nuclear medicine journals would be a better strategy due to several shortcomings of IF.

  2. Editorial: Biotechnology Journal brings more than biotechnology.

    PubMed

    Jungbauer, Alois; Lee, Sang Yup

    2015-09-01

    Biotechnology Journal always brings the state-of-the-art biotechnologies to our readers. Different from other topical issues, this issue of Biotechnology Journal is complied with a series of exiting reviews and research articles from spontaneous submissions, again, addressing society's actual problems and needs. The progress is a real testimony how biotechnology contributes to achievements in healthcare, better utilization of resources, and a bio-based economy.

  3. Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

    PubMed Central

    1994-01-01

    In the 13 years since it was first published the "Uniform requirements for manuscripts submitted to biomedical journals" (the Vancouver style), developed by the International Committee of Medical Journal Editors, has been widely accepted by both authors and editors; over 400 journals have stated that they will consider manuscripts that conform to its requirements. This is the fourth edition of the "Uniform requirements." PMID:8287338

  4. EDITORIAL: New scope for Journal of Physics D: Applied Physics New scope for Journal of Physics D: Applied Physics

    NASA Astrophysics Data System (ADS)

    Roche, Olivia; Margaritondo, Giorgio

    2011-10-01

    surface and interface science—and much of condensed matter physics—towards nanoscience. We are sure this merged section will bring the authors' work in both of these sections to a broader audience. All sections have seen some additions to, and removals from, the scope. A full copy of the new scope can be found at the end of this editorial. Some of the areas from which we are particularly keen to receive more papers include: photovoltaics, terahertz science and technology, plasmonics, spintronics, bulk magnetic materials, biomagnetism, graphene, plasma medicine and plasma propulsion. Many others are closely monitored as potential developments and we will act rapidly whenever necessary to avoid missing opportunities. As part of these changes, we will be asking all authors to explain their choice of journal section within the new scope. We will also ask authors to submit a short statement of the applications or potential applications of their work. This will allow us to assess the suitability of the research for the journal but will also allow us to highlight the most exciting research we publish, ensuring it gets the highest possible visibility. We would like to take this opportunity to thank our hard-working and dedicated publishing team and Editorial Board. We would also like to thank the authors and referees of JPhysD, without whom the journal could not exist. We believe these changes will allow further strengthening, development and growth of the journal and we look forward to a positive future for JPhysD.

  5. RESEARCH MISCONDUCT POLICIES OF SCIENTIFIC JOURNALS

    PubMed Central

    RESNIK, DAVID B.; PEDDADA, SHYAMAL; BRUNSON, WINNON

    2014-01-01

    The purpose of this study was to gather information on the misconduct policies of scientific journals. We contacted editors from a random sample of 399 journals drawn from the ISI Web of Knowledge database. We received 197 responses (49.4% response rate): 54.8% had a policy, and 47.7% had a formal (written) policy; 28.9% had a policy that only outlined procedures for handling misconduct, 15.7% had a policy that only defined misconduct, 10.2% had a policy that included both a definition and procedures; 26.9% of journals had a policy that was generated by the publisher, 13.2% had a policy that was generated by the journal, and 14.7% had a policy that was generated by another source, such as a professional association. We analyzed the relationship between having a policy and impact factor, field of science, publishing house, and nationality. Impact factor was the only variable with a statistically significant association with having a policy. Impact factor was slightly positively associated with whether or not the publisher had a policy, with an odds ratio of 1.49 (P < .0004) per 10 units increase in the impact factor, with a 95% confidence interval (1.20, 1.88). Our research indicates that more than half of scientific journals have developed misconduct policies, but that most of these policies do not define research misconduct and most of these policies were not generated by the journal. PMID:19757231

  6. Promotion of the Journal of Exercise Rehabilitation to the international level based on journal metrics

    PubMed Central

    Huh, Sun

    2016-01-01

    The aim of this study was to use journal metrics to confirm that the Journal of Exercise Rehabilitation has been promoted to the international level after changing its language to English-only in April 2013. Journal metrics, including the number of articles per year, countries of authors, countries of the editorial board members, impact factor, total citations, and the Hirsch index, were counted or calculated based on the journal homepage and the Web of Science Core Collection in December 2016. The number of citable articles was 52, 62, 59, and 74 in 2013, 2014, 2015, and 2016, respectively. All authors were from Korea in 2013 and 2014, but the authors were from 11 countries in 2015 and from 16 countries in 2016. The editorial board members are currently from 11 countries. The impact factor without self-citations for 2015 was 0.912, corresponding to a Journal Citation Reports ranking of 32.9% out of 82 journals in the category of sport sciences. The total citations increased from 1 in 2013 to 130 in 2016. This journal was cited in 208 other source journals in the Web of Science. The citing authors were from 47 countries. The Hirsch index was 7, and review articles were the most frequently cited articles. The above results show a rapid development to the international level over 4 years. The introduction of digital technology to journals to improve their accessibility across multiple platforms is recommended. PMID:28119870

  7. Malaysian Journal of Medical Sciences: A Step Forward towards an International Journal.

    PubMed

    Ghazli, Nur Farahin; Che Annual, Norfatiha; Abdullah, Jafri Malin

    2015-11-01

    In 1986, the Malaysian Journal of Medical Sciences (MJMS) began as the small and newly established journal Diagnosa, established by the Universiti Sains Malaysia School of Medicine. After 28 years in the publishing industry, we have received the honor of a listing as a local journal in the Emerging Sources Citation Index (ESCI) created by Thomson Reuters (TR) to spotlight emerging high-quality scientific publications. The editorial team of MJMS looks forward to the next step in the march of progress toward the status of an international journal.

  8. Editorial policies and good practices in editing the journal 'International Medical Journal--Medicus'.

    PubMed

    Pollozhani, Aziz

    2014-01-01

    Ten years ago the Association of Albanian Physicians in Macedonia undertook the very brave step of publishing a scientific medical journal, Medicus, as a platform for publishing biomedical research papers. Medical journal MEDICUS is an international peer-review journal of biomedical science. The first issue was published in 2004, starting with publishing two issues per year. From 2013, the journal delivered three issues per year, namely in January, May and September. Editor-in-Chief of the journal is Prof. Dr. Aziz Pollozhani. This year marks the tenth anniversary since publication of the first issue of Medicus, a fact that makes us proud and happy. The journal has its own official website (www.imjm.mk), where papers can be submitted and published in electronic form. In addition, the journal also comes out in print form to be distributed mainly in the region. Taking into account the specific socio-cultural characteristics of the region, the journal attempts to promote research activities in the region, while seeking to serve as an educational tool to promote scientific work in such a setting. As a result, Medicus accepts manuscripts for publication in English, Albanian and Macedonian, with a mandatory abstract in English for all papers. The journal Medicus represents a solid platform of biomedical sciences that will serve to advance scientific research and promote professional achievements in medicine.

  9. Promotion of the Journal of Exercise Rehabilitation to the international level based on journal metrics.

    PubMed

    Huh, Sun

    2016-12-01

    The aim of this study was to use journal metrics to confirm that the Journal of Exercise Rehabilitation has been promoted to the international level after changing its language to English-only in April 2013. Journal metrics, including the number of articles per year, countries of authors, countries of the editorial board members, impact factor, total citations, and the Hirsch index, were counted or calculated based on the journal homepage and the Web of Science Core Collection in December 2016. The number of citable articles was 52, 62, 59, and 74 in 2013, 2014, 2015, and 2016, respectively. All authors were from Korea in 2013 and 2014, but the authors were from 11 countries in 2015 and from 16 countries in 2016. The editorial board members are currently from 11 countries. The impact factor without self-citations for 2015 was 0.912, corresponding to a Journal Citation Reports ranking of 32.9% out of 82 journals in the category of sport sciences. The total citations increased from 1 in 2013 to 130 in 2016. This journal was cited in 208 other source journals in the Web of Science. The citing authors were from 47 countries. The Hirsch index was 7, and review articles were the most frequently cited articles. The above results show a rapid development to the international level over 4 years. The introduction of digital technology to journals to improve their accessibility across multiple platforms is recommended.

  10. Statistical Methods in Psychology Journals.

    ERIC Educational Resources Information Center

    Willkinson, Leland

    1999-01-01

    Proposes guidelines for revising the American Psychological Association (APA) publication manual or other APA materials to clarify the application of statistics in research reports. The guidelines are intended to induce authors and editors to recognize the thoughtless application of statistical methods. Contains 54 references. (SLD)

  11. How the launch of a new journal in 1904 may have changed the relationship between psychology and philosophy.

    PubMed

    Green, Christopher D; Feinerer, Ingo

    2017-02-01

    Recent research has used networks of scholarly journal articles to investigate the intellectual structure of the discipline of psychology from the later 1880s to the early 1920s. Here, instead, we examined the networks of philosophical journals that were closely aligned with psychology-The Monist, Philosophical Review, and The Journal of Philosophy, Psychology, and Scientific Methods-between 1890 and 1913. We discovered that, although the first 2 of these journals published a great deal of psychologically relevant material up to 1903, material of that sort seemed to evaporate after the launch of the third journal in 1904. It was not so much that material migrated from the old journals to the new one. It was rather that the new journal was able to attract new trends in American philosophical psychology, while interest in traditional approaches seemed to dry up. The result was that psychology moved into a new and expansive era, while America philosophy was left somewhat destabilized as it attempted to reconfigure its disciplinary identity. (PsycINFO Database Record

  12. Clinics in Orthopedic Surgery's Evolution into an International Journal Based on Journal Metrics

    PubMed Central

    2016-01-01

    This article is aimed at providing evidence of increased international recognition of Clinics in Orthopedic Surgery (CiOS) based on journal metrics. Since 7 years have passed since its launch in 2009, it is time to reflect on the journal's efforts to be recognized as a top-notch journal. The following journal metrics were analyzed from the journal's homepage and Web of Science Core Collection database: number of citable and noncitable articles; number of original articles supported by grants; editorial board members' countries; authors' countries; citing authors' countries; source titles of citing articles; impact factor; total citations; comparison of impact factor with 3 Science Citation Index Expanded journals; and Hirsch index (H-index). Of the total 392 articles, 378 were citable articles (96.4%). Of the total 282 original articles, 52 (18.4%) were supported by research grants. The editorial board members were from 13 countries. Authors were from 20 countries. The number of countries of citing authors was 66. The number of source titles of citing articles was more than 100. The total citations of CiOS have increased from 0 in 2009 to 374 in 2015. The impact factors without self-citations of CiOS were the greatest among 4 Asian journals in 2013 and 2014. The 2015 impact factor was calculated as 0.79 in January 2016. The H-index was 13. CiOS can be considered to have reached the level of top-notch journal in the orthopedic field based on journal metrics. The inclusion of the journal in PubMed Central appears to have increased international relevance of the journal. PMID:27247735

  13. Clinics in Orthopedic Surgery's Evolution into an International Journal Based on Journal Metrics.

    PubMed

    Huh, Sun

    2016-06-01

    This article is aimed at providing evidence of increased international recognition of Clinics in Orthopedic Surgery (CiOS) based on journal metrics. Since 7 years have passed since its launch in 2009, it is time to reflect on the journal's efforts to be recognized as a top-notch journal. The following journal metrics were analyzed from the journal's homepage and Web of Science Core Collection database: number of citable and noncitable articles; number of original articles supported by grants; editorial board members' countries; authors' countries; citing authors' countries; source titles of citing articles; impact factor; total citations; comparison of impact factor with 3 Science Citation Index Expanded journals; and Hirsch index (H-index). Of the total 392 articles, 378 were citable articles (96.4%). Of the total 282 original articles, 52 (18.4%) were supported by research grants. The editorial board members were from 13 countries. Authors were from 20 countries. The number of countries of citing authors was 66. The number of source titles of citing articles was more than 100. The total citations of CiOS have increased from 0 in 2009 to 374 in 2015. The impact factors without self-citations of CiOS were the greatest among 4 Asian journals in 2013 and 2014. The 2015 impact factor was calculated as 0.79 in January 2016. The H-index was 13. CiOS can be considered to have reached the level of top-notch journal in the orthopedic field based on journal metrics. The inclusion of the journal in PubMed Central appears to have increased international relevance of the journal.

  14. Characteristics of Open Access Journals in Six Subject Areas

    ERIC Educational Resources Information Center

    Walters, William H.; Linvill, Anne C.

    2011-01-01

    We examine the characteristics of 663 Open Access (OA) journals in biology, computer science, economics, history, medicine, and psychology, then compare the OA journals with impact factors to comparable subscription journals. There is great variation in the size of OA journals; the largest publishes more than 2,700 articles per year, but half…

  15. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  16. Rankings and Trends in Citation Patterns of Communication Journals

    ERIC Educational Resources Information Center

    Levine, Timothy R.

    2010-01-01

    Journal citations are increasingly used as indicators of the impact of scholarly work. Because many communication journals are not included in the Social Science Citation Index (SSCI), SSCI impact factors are potentially misleading for communication journals. The current paper reports a citation analysis of 30 communication journals based on…

  17. A Bibliometric Analysis of Communication Journals from 2002 to 2005

    ERIC Educational Resources Information Center

    Feeley, Thomas Hugh

    2008-01-01

    Journal impact ratings are often used by authors, promotion/hiring committees, and grant review teams as a proxy for scholarship quality. Journal citation data (2002-2005) from Social Sciences Citation Index were used to rank journals in the field of communication. A journal relatedness algorithm was applied to ascertain the 19 semantically…

  18. Totally Private & Personal: Journaling Ideas for Girls and Young Women.

    ERIC Educational Resources Information Center

    Wilber, Jessica

    This book offers journaling ideas for girls and young women ages 11-16, although it states that others who like to "journal" will find something here for them, too. The book discusses the reasons for journaling, including that it can serve as a good release when angry, sad, troubled, or even happy. The book also states that a journal is…

  19. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  20. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  1. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  2. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  3. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  4. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  5. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  6. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  7. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  8. Getting the Most Out of Journaling: Strategies for Outdoor Educators.

    ERIC Educational Resources Information Center

    Dyment, Janet E.; O'Connell, Timothy S.

    2003-01-01

    Outdoor educators often ask students to write journals without training them in journal writing. A workshop in journal writing for university students in outdoor education courses covers how to write entries related to specific content areas; an understanding of Bloom's Taxonomy of Cognitive Thinking and how it applies to journal writing; and…

  9. Subject Journal Review: Personnel Management and Industrial Psychology.

    ERIC Educational Resources Information Center

    Herman, Georgianna

    1984-01-01

    This annotated bibliography lists 35 primary journals devoted to personnel management and industrial psychology in such categories as human resource planning, employee training, compensation, and employment law. History of the field, journal selection, journal specializations (for practitioners and academicians), journal indexing/abstracting,…

  10. Status of Journals in the Field of Higher Education

    ERIC Educational Resources Information Center

    Bray, Nathaniel J.; Major, Claire H.

    2011-01-01

    During the past 50 years, the field of higher education has experienced growth, maturation, and specialization, coinciding with an almost exponential increase in the number of higher education journals. The proliferation of journals has led to an increased focus on journal status by members of the field. Not surprisingly, an informal journal caste…

  11. Quality Australian Journals in the Humanities and Social Sciences

    ERIC Educational Resources Information Center

    Haddow, Gaby

    2008-01-01

    A pilot study was undertaken to test the journal diffusion factor (JDF) as an alternative to journal impact factors (JIFs) for ranking journals. Bibliometric research methods were applied to rank Australian architecture, communications and education journals by the JDF; this was with the total number of citations they attract in ISI indexed…

  12. Deal or No Deal? Evaluating Big Deals and Their Journals

    ERIC Educational Resources Information Center

    Blecic, Deborah D.; Wiberley, Stephen E., Jr.; Fiscella, Joan B.; Bahnmaier-Blaszczak, Sara; Lowery, Rebecca

    2013-01-01

    This paper presents methods to develop metrics that compare Big Deal journal packages and the journals within those packages. Deal-level metrics guide selection of a Big Deal for termination. Journal-level metrics guide selection of individual subscriptions from journals previously provided by a terminated deal. The paper argues that, while the…

  13. Editorial: New Publishing Information for The Astrophysical Journal

    NASA Astrophysics Data System (ADS)

    Vishniac, Ethan; Sneden, Christopher

    2008-10-01

    The Astrophysical Journal, including the Letters, is in the process of changing publishers. Starting January 1 the Institute of Physics will be our publishers. We look forward to working with our new publishing partners, and appreciate the hard work of the many people who have prepared for a smooth transition. We have had a long and close relationship with the University of Chicago Press, and while circumstances have led to its end, we owe a large debt to its dedicated staff who have made the Journal a success for many years. Submissions to the main journal are no longer accepted at the University of Chicago Press, but should be submitted via the IOP Web portal for the AAS journals at http://journals.aas.org. Due to the shorter lead time for publication in the Letters, submissions for the Letters will switch over on October 15. Articles submitted through the University of Chicago Press will remain with them until toward the end of November (data will be transferred over the Thanksgiving weekend). At that point articles that are still in the refereeing process will be transferred to the Institute of Physics. This will have no effect on the refereeing process itself. Authors will still be corresponding with the same editors and referees through the new Web site. The change in publishers is only part of the evolution of the Journal in response to the opportunities and challenges posed by the new electronic era in publishing. We will be looking for new ways to facilitate the dissemination of scientific articles and to link with other electronic resources. In the short term, we expect to continue the transition from a paper journal to an electronic one. Starting in January, the Astrophysical Journal Letters will become a "print on demand" journal. Technology has not yet reached the point where online articles are a complete replacement for paper copies, but it is more convenient to generate printed copies as close to the readers as possible, and in response to specific

  14. Ranking Predatory Journals: Solve the Problem Instead of Removing It!

    PubMed Central

    Dadkhah, Mehdi; Bianciardi, Giorgio

    2016-01-01

    Predatory journals are a well-known issue for scholarly publishing and they are repositories for bogus research. In recent years, the number of predatory journals has risen and it is necessary to present a solution for this challenge. In this paper, we will discuss about a possible ranking of predatory journals. Our ranking approach is based on Beall’s criteria for detection of predatory journals and it can help editors to improve their journals or convert their questionable journals to non-predatory ones. Moreover, our approach could help young editors to protect their journals against predatory practice. Finally, we present a case study to clarify our approach. PMID:27123411

  15. AGU journals increase in importance according to 2010 Impact Factors

    NASA Astrophysics Data System (ADS)

    Cook, Bill

    2011-07-01

    AGU journals continue to rank highly in many categories in the 2010 Journal Citation Report (JCR), which was released by Thomson Reuters on 28 June. JCR reports on several measures of journal usage, including a journal's Eigenfactor score, its Article Influence score, its Impact Factor, and its rank within a cohort of similar journals. According to the 2010 statistics, AGU again has outperformed its larger competitors. Four different AGU titles are ranked in the top three journals in six different cohorts. The Impact Factor of several AGU journals increased significantly over the previous year.

  16. Ranking Predatory Journals: Solve the Problem Instead of Removing It!

    PubMed

    Dadkhah, Mehdi; Bianciardi, Giorgio

    2016-03-01

    Predatory journals are a well-known issue for scholarly publishing and they are repositories for bogus research. In recent years, the number of predatory journals has risen and it is necessary to present a solution for this challenge. In this paper, we will discuss about a possible ranking of predatory journals. Our ranking approach is based on Beall's criteria for detection of predatory journals and it can help editors to improve their journals or convert their questionable journals to non-predatory ones. Moreover, our approach could help young editors to protect their journals against predatory practice. Finally, we present a case study to clarify our approach.

  17. How much progress has been made in journal metrics two years after the citation analysis of the Korean Journal of Urology?

    PubMed Central

    2015-01-01

    Purpose In April 2013, the journal metrics of the Korean Journal of Urology (KJU) were reported. That report showed tremendous improvement from the point of view of journal metrics. Two years later, the same metrics were reanalyzed to determine the present position of the KJU among the international journals in the Web of Science. Materials and Methods I analyzed journal metrics of the KJU such as impact factor, total citations, and h-index by use of the same methods as in the previous report. Results Total citations in the Web of Science were 332 in 2012, 439 in 2013, and 578 in 2014. Manually calculated impact factors from 2012 to 2014 were 0.770, 0.824, and 0.751, respectively. There was an increase in the h-index from 8 in 2012 to 11 in February 2015. Editorial board members were from 15 countries in 2014. Authors of KJU articles were from 21 countries in 2014. Conclusions During 2 years, remarkable progress was made in KJU's citation indicators and in the diversity of the authors' and editorial board members' countries. PMID:25874040

  18. Carbon Nanotubes: Miracle of Materials Science?

    NASA Technical Reports Server (NTRS)

    Files, Bradley S.; Mayeaux, Brian M.

    1999-01-01

    Article to be sent to Advanced Materials and Processes, journal of ASM International, as attached. This is a news-type technical journal for a large organization of scientists, engineers, salesmen, and managers. The article is quite general, meant to be an introduction to the properties of nanotubes. This is a materials science organization, therefore the article is geared toward using nanotubes for materials uses. Pictures have not been included in this version.

  19. Educational Technology Research Journals: "Journal of Distance Education," 2003-2012

    ERIC Educational Resources Information Center

    Young, Eric H.; Griffiths, Ty; Luke, Brandon; West, Richard E.

    2014-01-01

    In this study the authors analyzed articles published in the "Journal of Distance Education" from 2003-2012. They analyzed the frequency of author-provided keywords and common abstract phrases, type and frequency of authorship, the type of research method employed, and the number of citations the journal and specific articles received.…

  20. The York Digital Journals Project: Strategies for Institutional Open Journal Systems Implementations

    ERIC Educational Resources Information Center

    Kosavic, Andrea

    2010-01-01

    Embarking on a universitywide journal-hosting initiative can be a resource-intensive undertaking. Providing such a service, however, can be equally rewarding, as it positions the library as both partner and colleague in the publishing process. This paper discusses ideas and strategies for institutional journal hosting gleaned over two years by the…

  1. Macedonian journal of chemistry and chemical engineering: open journal systems--editor's perspective.

    PubMed

    Zdravkovski, Zoran

    2014-01-01

    The development and availability of personal computers and software as well as printing techniques in the last twenty years have made a profound change in the publication of scientific journals. Additionally, the Internet in the last decade has revolutionized the publication process to the point of changing the basic paradigm of printed journals. The Macedonian Journal of Chemistry and Chemical Engineering in its 40-year history has adopted and adapted to all these transformations. In order to keep up with the inevitable changes, as editor-in-chief I felt my responsibility was to introduce an electronic editorial managing of the journal. The choice was between commercial and open source platforms, and because of the limited funding of the journal we chose the latter. We decided on Open Journal Systems, which provided online submission and management of all content, had flexible configuration--requirements, sections, review process, etc., had options for comprehensive indexing, offered various reading tools, had email notification and commenting ability for readers, had an option for thesis abstracts and was installed locally. However, since there is limited support it requires a moderate computer knowledge/skills and effort in order to set up. Overall, it is an excellent editorial platform and a convenient solution for journals with a low budget or journals that do not want to spend their resources on commercial platforms or simply support the idea of open source software.

  2. Journalism 2.0: Exploring the Impact of Mobile and Social Media on Journalism Education

    ERIC Educational Resources Information Center

    Cochrane, Thomas; Sissons, Helen; Mulrennan, Danni; Pamatatau, Richard

    2013-01-01

    This paper explores the impact of social media upon journalism education from two perspectives: both from the pedagogical changes Web 2.0 and mobile devices enable, and within the context of the changes in journalism that social media use are driving. A participatory action research approach was adopted, beginning with the establishment of a…

  3. Educational Technology Research Journals: "Journal of Computer Assisted Learning," 2002-2011

    ERIC Educational Resources Information Center

    Welch, Kyle R.; Zabriskie, Grant D.; Ashton, Scott M.; Borup, Jered; West, Richard E.

    2014-01-01

    In this study, the authors analyzed all research articles published between 2002 and 2011 in the "Journal of Computer Assisted Learning," in order to understand the research topics methods, major contributing authors, and most-cited publications. Over the 10-year period, they found the journal has explored educational uses of computer…

  4. Journal Impact Factors and Self-Citations: Implications for Psychology Journals

    ERIC Educational Resources Information Center

    Anseel, Frederik; Duyck, Wouter; De Baene, Wouter; Brysbaert, Marc

    2004-01-01

    Comments on the study by J. G. Adair and N. Vohra (see record 2003-02034-002) of changes in the number of references and citations in psychology journals as a consequence of the current knowledge explosion. They made a striking observation of the sometimes excessive number of self-citations in psychology journals. However, after this illustration,…

  5. The Costs of Providing Electronic Journal Access and Printed Copies of Journals to University Users

    ERIC Educational Resources Information Center

    Cooper, Michael D.

    2006-01-01

    Six models are developed to analyze the cost options the University of California faces in providing access to academic journals. The driving force in this analysis is a movement by publishers to deliver the content of their journals via the Internet. The models assume electronic access will always be provided. Researchers like this capability…

  6. Educational Technology Research Journals: "Journal of Research on Technology in Education," 2001-2010

    ERIC Educational Resources Information Center

    Billings, Christopher; Nielsen, P. Lynne; Snyder, Aaron; Sorensen, Alec; West, Richard E.

    2012-01-01

    In this study, the authors examined the "Journal of Research on Technology in Education (JRTE)" to discover trends from 2001-2010 in the topics covered in the articles, article types (including research methods used), authorship, and citation frequency. Articles from the journal dealt mostly with PK-12 settings and focused on technology…

  7. Research on Children's Play: Analysis of Developmental and Early Education Journals from 2005 to 2007

    ERIC Educational Resources Information Center

    Cheng, Mei-Fang; Johnson, James E.

    2010-01-01

    Our review examined four early childhood journals ("Early Child Development and Care," "Early Childhood Education Journal," "Journal of Research in Childhood Education," and "Early Childhood Research Quarterly") and four developmental science journals ("Child Development," "Developmental Psychology," "Journal of Applied Developmental…

  8. Source diversity among journals cited in Science Times.

    PubMed

    Kiernan, Vincent

    2016-02-01

    A content analysis of The New York Times' Science Times section from 1998 to 2012 found evidence of increased source diversity in use of scientific journals as news sources. Science Times increased the frequency at which it cited journals, the number of different journals that it cited, and the number of disciplines represented by cited journals. The results suggest that online availability of a wide array of scientific journals has changed sourcing behaviors.

  9. Wave Journal Bearing. Part 1: Analysis

    NASA Technical Reports Server (NTRS)

    Dimofte, Florin

    1995-01-01

    A wave journal bearing concept features a waved inner bearing diameter of the non-rotating bearing side and it is an alternative to the plain journal bearing. The wave journal bearing has a significantly increased load capacity in comparison to the plain journal bearing operating at the same eccentricity. It also offers greater stability than the plain circular bearing under all operating conditions. The wave bearing's design is relatively simple and allows the shaft to rotate in either direction. Three wave bearings are sensitive to the direction of an applied stationary side load. Increasing the number of waves reduces the wave bearing's sensitivity to the direction of the applied load relative to the wave. However, the range in which the bearing performance can be varied decreases as the number of waves increases. Therefore, both the number and the amplitude of the waves must be properly selected to optimize the wave bearing design for a specific application. It is concluded that the stiffness of an air journal bearing, due to hydrodynamic effect, could be doubled and made to run stably by using a six or eight wave geometry with a wave amplitude approximately half of the bearing radial clearance.

  10. Data Behind the Figures in AAS Journals

    NASA Astrophysics Data System (ADS)

    Biemesderfer, Chris

    2013-01-01

    Substantial amounts of digital data are produced in the scientific enterprise, and much of it is carefully analyzed and processed. Often resulting from a good deal of intellectual effort, many of these highly-processed products are published in the scholarly literature. Many of these data - or more precisely, representations of these data - are committed to the scholarly record in the forms of figures and tables that appear within articles: the AAS journals publish more than 30,000 figures and nearly 10,000 tables each year. For more than a decade, the AAS journals have accepted machine-readable tables that provide the data behind (some of) the tables, and recently the journals have started to encourage the submission of the data behind figures. (See the related poster by Greg Schwarz.) During this time, the journals have been refining techniques for acquiring and managing the digital data that underlie figures and tables. In 2012 the AAS was awarded a grant by the US NSF so that the journals can extend the methods for providing access to these data objects, through a deeper collaboration with the VO and with organizations like DataCite, and by spearheading discussions about the formats and metadata that will best facilitate long-term data management and access. An important component of these activities is educating scientists about the importance and benefits of making such data sets available.

  11. Mapping the Journal of Homosexuality: A Preface.

    PubMed

    Wahlert, Lance

    2016-01-01

    This article serves as a Preface to the supplementary section of this special issue on "Mapping Queer Bioethics," in which we take a solipsistic turn to "map" the Journal of Homosexuality itself. Born contemporaneously with the depathologization of "homosexuality" in the early 1970s, how does the Journal of Homosexuality's commitment to LGBT health issues the past four decades reveal longstanding tensions between medical pathology, cultural appropriation, and political progress? Introducing the articles that follow (each of which examines a seminal medical-themed subject from the journal's history), this article asks how LGBT-sensitive academic texts play complicit roles in both the reinforcement and the liberation of queer subjects in biomedical discourse.

  12. Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.

    PubMed

    Singh, Bhupendra; Bhat, Nimee K; Bhat, Hari K

    2012-01-01

    Exact mechanisms underlying the initiation and progression of estrogen-related cancers are not clear. Literature, evidence and our studies strongly support the role of estrogen metabolism-mediated oxidative stress in estrogen-induced breast carcinogenesis. We have recently demonstrated that antioxidants vitamin C and butylated hydroxyanisole (BHA) or estrogen metabolism inhibitor α-naphthoflavone (ANF) inhibit 17β-estradiol (E2)-induced mammary tumorigenesis in female ACI rats. The objective of the current study was to identify the mechanism of antioxidant-mediated protection against E2-induced DNA damage and mammary tumorigenesis. Female ACI rats were treated with E2 in the presence or absence of vitamin C or BHA or ANF for up to 240 days. Nuclear factor erythroid 2-related factor 2 (NRF2) and NAD(P)H-quinone oxidoreductase 1 (NQO1) were suppressed in E2-exposed mammary tissue and in mammary tumors after treatment of rats with E2 for 240 days. This suppression was overcome by co-treatment of rats with E2 and vitamin C or BHA. Time course studies indicate that NQO1 levels tend to increase after 4 months of E2 treatment but decrease on chronic exposure to E2 for 8 months. Vitamin C and BHA significantly increased NQO1 levels after 120 days. 8-Hydroxydeoxyguanosine (8-OHdG) levels were higher in E2-exposed mammary tissue and in mammary tumors compared with age-matched controls. Vitamin C or BHA treatment significantly decreased E2-mediated increase in 8-OHdG levels in the mammary tissue. In vitro studies using silencer RNA confirmed the role of NQO1 in prevention of oxidative DNA damage. Our studies further demonstrate that NQO1 upregulation by antioxidants is mediated through NRF2.

  13. Clinical Microbiology Reviews: genesis of a journal.

    PubMed

    Morello, J A

    1999-04-01

    In 1986 planning for a new ASM review journal, Clinical Microbiology Reviews (CMR), began. CMR would publish articles primarily of interest to persons concerned with pathogenesis, laboratory diagnosis, epidemiology, and control of human and veterinary pathogens. The first issue was published in January 1988, with quarterly publication since then. The journal quickly became successful in terms of subscribers and impact on the field, earning a strong national and international reputation. The achievements of CMR are owed to many persons, including the editorial board, the production team, and especially the contributing authors.

  14. Selecting the right journal for your submission.

    PubMed

    Welch, Stephen J

    2012-06-01

    Increasing pressure on researchers and academic clinicians to publish high volumes of work in highly visible publication outlets means that authors must have a finely tuned, efficient process for submission. One of the key decisions every author must make is where to submit their paper. This article addresses several important components to making that decision, including (I) topic match; (II) acceptance/rejection rate of the journal; (III) speed of review/publication; (IV) distribution of and access to the journal; and (V) impact factor.

  15. Witze receives 2000 Walter Sullivan Award for Excellence in Science Journalism

    NASA Astrophysics Data System (ADS)

    Siegfried, Tom; Witze, Alexandra

    Alexandra Witze was awarded the 2000 Walter Sullivan Award for Excellence in Science Journalism at the AGU Spring Meeting Honors Ceremony, which was held on June 2, 2000, in Washington, D.C. The award recognizes a single article or a radio/television report that makes geophysical material accessible and interesting to the general public.

  16. The Teacher Trainer, A Practical Journal Mainly for Modern Language Teacher Trainers, 1997.

    ERIC Educational Resources Information Center

    Woodward, Tessa, Ed.

    1997-01-01

    The three issues of the journal on second language teacher education include these articles: "Monitoring and Evaluating the Production of Materials on a Large Scale Trainer Training Workshop" (R. Williams, Choong Kam Foong, Diana Lubelska); Sensory Channels in ESL Instruction" (Michael E. Rudder); "Using the In-Service Feedback…

  17. Freedom of the Press: A Simulation of Legal Issues in Journalism. [Kit].

    ERIC Educational Resources Information Center

    Katsh, Ethan

    A 4-day simulation activity encourages high school students to confront issues of law and journalism through exploration of seven legal issues: prior restraint, access to courts, rights of reply, libel, privacy, confidential sources, and use of stolen documents. The kit contains all materials needed for the simulation, including a director's…

  18. Retention of retrospective print journals in the digital age: trends and analysis

    PubMed Central

    Kaplan, Richard; Steinberg, Marilyn; Doucette, Joanne

    2006-01-01

    Purpose: The issue of retaining retrospective print journals is examined in light of the shift to electronic titles, the reallocation of library budgets from print to electronic, and the changing research practices of today's library users. This article also examines the evolving role of the physical library and its impact on space allocation. Methods: To determine current practice and opinion, a survey of health sciences librarians and academic librarians was conducted. To demonstrate the use patterns of older journal issues, citation analyses and interlibrary loan statistics were examined. Results: All methods indicate that recent material is accessed more frequently than older material, with a significant drop in use of materials greater than 15 years old. Materials greater than 20 years old constituted less than 5% of interlibrary loans and less than 9% of articles noted in the citation analysis. Conclusions: It is possible to eliminate older years of a print journal collection without a large impact on the needs of researchers. Librarians' preference to maintain full runs of journal titles may be motivated by reasons outside of actual usage or patrons needs. PMID:17082829

  19. "Xchanges Journal"--Web Journal as the Writing Classroom: On Building an Academic Web Journal in a Collaborative Classroom

    ERIC Educational Resources Information Center

    Boles, Jacoby; Newmark, Julianne

    2011-01-01

    This website is the creation of one of Julianne Newmark's students, Jacoby Boles, the Editorial Assistant for the e-journal "Xchanges." Jacoby reflects, via this site, on his experiences as a member of the Technical Communication 371 "Publications Management" course at New Mexico Tech. This course was explicitly designed to…

  20. Revista de Documentacao de Estudos em Liguistica Teorica e Aplicada, 1998 (Journal of Documentary Studies in Linguistic Theory and Application, 1998).

    ERIC Educational Resources Information Center

    Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

    1998-01-01

    This document consists of three issues of DELTA, comprising its entire output for 1998. DELTA is a journal of theoretical and applied linguistics and covers a wide variety of material related to language, speech, and education. The journal publishes only original research and ideas presented in the form of articles, debates, squibs, overviews,…